WorldWideScience

Sample records for biological safety cabinets

  1. Laboratory biological safety cabinet (BSC) explosion

    Energy Technology Data Exchange (ETDEWEB)

    Al-Dahhan, Wedad H.; Al-Zuhairi, Ali Jasim; Hussein, Falah H.; Rodda, Kabrena E.; Yousif, Emad

    2016-12-01

    Scientists at universities across Iraq are actively working to report actual incidents and accidents occurring in their laboratories in order to raise awareness and encourage openness, leading to widespread adoption of robust Chemical Safety and Security (CSS) practices. This manuscript is the first in a series of five case studies describing laboratory incidents and accidents in Iraqi university laboratories in order to share lessons learned and minimize the possibility of similar incidents in the future. In this study, we describe a serious event that resulted in a postgraduate student sustaining serious injuries when the biological safety cabinet (BSC) she was using exploded. Of particular note, the paper highlights how a combination of failures and deficiencies at many levels within an organization and its technical community (rather than a single piece of faulty equipment or the careless behavior of one person) can lead to a dangerous, potentially life-threatening incident. By openly sharing what happened along with the lessons learned from the accident, we hope to minimize the possibility of another researcher being injured in a similar incident in the future.

  2. Validation of cross-contamination control in biological safety cabinet for biotech/pharmaceutical manufacturing process.

    Science.gov (United States)

    Hu, Shih-Cheng; Shiue, Angus; Tu, Jin-Xin; Liu, Han-Yang; Chiu, Rong-Ben

    2015-12-01

    For class II, type A2 biological safety cabinets (BSC), NSF/ANSI Standard 49 should be conformed in cabinet airflow velocity derivation, particle contamination, and aerodynamic flow properties. However, there exists a potential problem. It has been built that the cabinet air flow stabilize is influenced by the quantity of downflow of air and the height above the cabinet exhaust opening. Three air downflow quantities were compared as an operating apparatus was placed from 20 to 40 cm above the bench of the cabinet. The results show that the BSC air downflow velocity is a function of increased sampling height, displaying that containment is improvingly permitted over product protection as the sampling height decreases. This study investigated the concentration gradient of particles at various heights and downflow air quantity from the bench of the BSC. Experiment results indicate that performance near the bench was better than in the rest of the BSC. In terms of height, the best cleanliness was measured at a height of 10 cm over the bench; it reduced actually with add in height. The empirical curves accommodate, founded on the concentration gradient of particle created was elaborated for evaluating the particle concentration at different heights and downflow air quantity from the source of the bench of the BSC. The particle image velocimetry system applied for BSC airflow research to fix amount of airflow patterns and air distribution measurement and results of measurements show how obstructions can greatly influence the airflow and contaminant transportation in a BSC.

  3. Microbiological safety cabinets, cytotoxic safety cabinets. Choice and use

    International Nuclear Information System (INIS)

    Balty, I.; Belhanini, B.; Clermont, H.; Cornu, J.C.; Jacquet, M.A.; Texte, J.C.

    2003-01-01

    Drawn up by a working group composed of prevention professionals, manufacturers and control bodies, this guide is intended to help those responsible for safety in laboratories choose and acquire materials responding to the intended protection objectives. It provides recommendations for the commissioning and control of these materials as well as for their use. After a description of the operational characteristics of safety cabinets, this guide looks at the important points to be taken into account when ordering, accepting and commissioning equipment adapted to precise needs. It also covers verification of correct operation and provides a number of common sense rules relative to precautions for use. Material cleaning and decontamination is described briefly on account of the very specialized character of this activity. Detailed information relative to this subject should be sought in the literature. (authors)

  4. Environmental contamination by cyclophosphamide preparation: Comparison of conventional manual production in biological safety cabinet and robot-assisted production by APOTECAchemo.

    Science.gov (United States)

    Schierl, Rudolf; Masini, Carla; Groeneveld, Svenja; Fischer, Elke; Böhlandt, Antje; Rosini, Valeria; Paolucci, Demis

    2016-02-01

    The aim of this study was to compare environmental contamination of cyclophosphamide (CP) during 1 week of drug compounding by conventional manual procedure in a biological safety cabinet (BSC) with laminar airflow and a new robotic drug preparation system (APOTECAchemo). During four consecutive days, similar numbers of infusion bags with cyclophosphamide were prepared with both techniques in a cross-over design. Wipe samples (49 for BSC, 50 for APOTECAchemo) were taken at several locations (gloves, infusion bags, trays, BSC-benches, floor) in the pharmacy and analyzed for CP concentrations by GC-MSMS (LOD 0.2 ng/sample). The detection rate was 70% in the BSC versus 15% in APOTECAchemo. During manual preparation of admixtures using BSC contamination with CP was below 0.001 ng/cm(2) at most locations, but significant on gloves (0.0004-0.0967 ng/cm(2)) and the majority (70%) of infusion bags (preparation by APOTECAchemo, gloves (1 of 8: 0.0007 ng/cm(2)) and infusion bags (3 of 20: 0.0005, 0.0019, 0.0094 ng/cm(2)) were considerably less contaminated. Residual contamination was found on the surfaces under the dosing device in the compounding area (0.0293-0.1603 ng/cm(2)) inside the robotic system. Compared to outcomes of other studies, our results underline good manufacturing procedures in this pharmacy with low contamination for both techniques (BSC and APOTECAchemo). Comparison of both preparation procedures validated that contamination of infusion bags was much lower by using the robotic system. © The Author(s) 2014.

  5. Seismic qualification of multiple interconnected safety-related cabinets in a high seismic zone

    International Nuclear Information System (INIS)

    Khan, M.R.; Chen, W.H.W.; Wang, T.Y.

    1993-01-01

    Certain safety-related multiple, interconnected electrical cabinets and the devices contained therein are required to perform their intended safety functions during and after a design basis seismic event. In general, seismic testing is performed to ensure the structural integrity of the cabinets and the functionality of their associated devices. Constrained by the shake table capacity, seismic testing is usually performed only for a limited number of interconnected cabinets. Also, original shake table tests performed usually did not provide detailed response information at various locations inside the cabinets. For operational and maintenance purposes, doors and panels of some cabinets may need to be opened while the adjacent cabinets are required to remain functional. In addition, in-cabinet response spectra need to be generated for the seismic qualification of new devices and the replacement parts. Consequently, seismic analysis of safety-related multiple, interconnected cabinets is frequently required for configurations which are different from the original tested conditions. This paper presents results of seismic tests of three interconnected safety-related cabinets and finite element analyses performed to compare the analytical results with those obtained from the cabinet seismic tests. Parametric analyses are performed to determine how many panels and doors can be opened while the adjacent cabinets still remain functional. The study indicates that for cabinets located in a high seismic zone, the critical damping of the cabinet is significantly higher than 5% to 7% typically used in qualifying electrical equipment. For devices mounted on the cabinet doors to performed their intended safety function, it requires stiffening of doors and that these doors be properly bolted to the cabinet frame. It also shows that even though doors and panels bolted to the cabinet frame are the primary seismic resistant element of the cabinet, opening of a limited number of them

  6. Work cabinet

    International Nuclear Information System (INIS)

    Hornby, L.

    1981-01-01

    A simple work cabinet is described for handling materials such as radiopharmaceuticals. The cabinet includes a perforated working surface to which an operator can gain hand and forearm access through an aperture. Clean air is supplied through a high efficiency particulate air filter and withdrawn through the perforated surface. (U.K.)

  7. Phototherapy cabinet for ultraviolet radiation therapy

    International Nuclear Information System (INIS)

    Horwitz, S.N.; Frost, P.

    1981-01-01

    A newly designed cabinet can be used for the treatment of psoriasis with fluorescent ultraviolet (UV) lamps. the new design provides more uniform distribution of UV radiation in both the horizontal and vertical axes, and several safety features have been added. The distribution and uniformity of UV output in this and in a previously described cabinet are compared. The UV output at the vertical center of the older UV light cabinet was six times greater than that at either the top or bottom, while the design of the present cabinet provides uniform UV radiation except for a slight increase at head height and at the level of the lower legs compared with the middle third of the cabinet. The variation in output of the older cabinet may, in part, explain the commonly encountered difficulty in the phototherapy of psoriasis of the scalp and lower extremities

  8. Failure cause analysis and improvement for magnetic component cabinet

    International Nuclear Information System (INIS)

    Ge Bing

    1999-01-01

    The magnetic component cabinet is an important thermal control device fitted on the nuclear power. Because it used a self-saturation amplifier as a primary component, the magnetic component cabinet has some boundness. For increasing the operation safety on the nuclear power, the author describes a new scheme. In order that the magnetic component cabinet can be replaced, the new type component cabinet is developed. Integrate circuit will replace the magnetic components of every function parts. The author has analyzed overall failure cause for magnetic component cabinet and adopted some measures

  9. Nursing perception of the impact of automated dispensing cabinets on patient safety and ergonomics in a teaching health care center.

    Science.gov (United States)

    Rochais, Elise; Atkinson, Suzanne; Guilbeault, Mélanie; Bussières, Jean-François

    2014-04-01

    To evaluate how nursing staff felt about the impact of automated dispensing cabinets (ADCs) on the safe delivery of health care and workplace ergonomics. To identify the main issues involved in the use of this technology and to describe the corrective measures implemented. Cross-sectional descriptive study with quantitative and qualitative components. A questionnaire that consisted of 33 statements about ADC was distributed from May 24 to June 3, 2011. A total of 172 (46%) of 375 nurses completed the questionnaire. Nursing staff considered the introduction of ADC made their work easier (level of agreement of 90%), helped to safely provide patients with care (91%), and helped to reduce medication incidents/accidents (81%). Nursing staff was particularly satisfied by the narcotic drugs management with the ADCs. Nursing staff were not satisfied with the additional delays in the preparation and administration of a medication dose and the inability to prevent a medication from being administered when stopped on the medication administration record (48%). The nursing staff members were satisfied with the use of ADC and believed it made their work easier, promoted safe patient care, and were perceived to reduce medication incidents/accidents.

  10. Terrorism and cabinet duration

    NARCIS (Netherlands)

    Gassebner, M.; Jong-A-Pin, R.; Mierau, J.O.

    2011-01-01

    Terrorism can strengthen or weaken electoral support for ruling governments. We show in a simple model of coalition formation that, regardless of the direction of a public opinion shock, the impact of terrorism on cabinet duration is ambiguous. However, in an analysis of a data set including 2,400

  11. International Workshop on Post-Accident Food Safety Science, Hosted by the Cabinet Office, Government of Japan

    International Nuclear Information System (INIS)

    Tsukada, Hirofumi; Oikawa, Shinji; Aoki, Jin; Fujii, Masahiro; Okabe, Yoko; Koyama, Ryota; Iracane, Daniel; Lazo, Ted; ); Theelen, Rob; Sekiya, Naoya; Ito, Toshihiko; Kazumata, Seiichi; Hatta, Nobuyuki; Yuasa, Osamu; Nonaka, Shunkichi; Sato, Chie; Nisbet, Anne; Kai, Michiaki; Gusev, Igor; ); Nosske, Dietmar; Vandenhove, Hildegarde; Leonard, Kinson; Perks, Christopher; Liland, Astrid; Mostovenko, Andrei; Arai, Yoshimitsu; Sato, Mamoru; Kokubun, Youichi; Nemoto, Yoshiharu; Boyd, Mike; Homma, Toshimitsu; ); Lecomte, Jean Francois; Perks, Christopher

    2016-11-01

    Following the Fukushima Daiichi Nuclear Power Plant accident in March 2011, considerable public concern arose regarding the management of food in and from Japan. These concerns were raised in Japan, as well as in surrounding countries. Unfortunately, it was quickly realised that the existing frameworks for decision-making with regard to food safety seemed inadequate for addressing the challenges presented by this unprecedented event. The areas affected by the accident are heavily agricultural, producing many food products, including rice, vegetables, beef, persimmons and peaches. In addition, the area is an important region for fisheries in Japan. The food products of the region had been very well-regarded both in Japan and abroad. However, some of the people living in affected areas remain concerned for their health and for their future livelihood. In the aftermath of the accident, populations living outside the directly affected areas were also concerned about consuming food products from Fukushima. In Tokyo, which is located approximately 240 km south of Fukushima, some shops ceased entirely to carry certain food items, simply because the best examples were commonly from the Fukushima region. Many of Japan's trading partners, which were concerned about importing food thought to be contaminated, showed similar reactions. These concerns posed a complex, multi-layered problem with local, national and international implications, for which there were no broad, internationally-agreed approaches. This stands as an important lesson to be absorbed from the accident and highlights a need for international focus. To secure distribution of safe agricultural and livestock products, good agricultural practices to produce safe food and feed, including reduction measures of radionuclides from farmland, have been implemented in Japan. The regulation limits have been set consistent with the approach stipulated in the international standards/guidelines, i.e. Codex guidelines

  12. Refrigerated display cabinets; Butikskyla

    Energy Technology Data Exchange (ETDEWEB)

    Fahlen, Per

    2000-07-01

    This report summarizes experience from SP research and assignments regarding refrigerated transport and storage of food, mainly in the retail sector. It presents the fundamentals of heat and mass transfer in display cabinets with special focus on indirect systems and secondary refrigerants. Moreover, the report includes a brief account of basic food hygiene and the related regulations. The material has been compiled for educational purposes in the Masters program at Chalmers Technical University.

  13. Acceptance Test Plan for Fourth-Generation Corrosion Monitoring Cabinet

    International Nuclear Information System (INIS)

    NORMAN, E.C.

    2000-01-01

    This Acceptance Test Plan (ATP) will document the satisfactory operation of the third-generation corrosion monitoring cabinet (Hiline Engineering Part No.0004-CHM-072-C01). This ATP will be performed by the manufacturer of the cabinet prior to delivery to the site. The objective of this procedure is to demonstrate and document the acceptance of the corrosion monitoring cabinet. The test will consist of a continuity test of the cabinet wiring from the end of cable to be connected to corrosion probe, through the appropriate intrinsic safety barriers and out to the 15 pin D-shell connectors to be connected to the corrosion monitoring instrument. Additional testing will be performed using a constant current and voltage source provided by the corrosion monitoring hardware manufacturer to verify proper operation of corrosion monitoring instrumentation

  14. Biologicals and biosimilars: safety issues in Europe.

    Science.gov (United States)

    Portela, Maria da Conceição Constantino; Sinogas, Carlos; Albuquerque de Almeida, Fernando; Baptista-Leite, Ricardo; Castro-Caldas, Alexandre

    2017-07-01

    Medicinal products of a biological origin are approved by the EMA at a centralized level. However, there is no harmonization about their use in Europe. The current regulation referring to the safety of biological medicinal products and biosimilars in Europe has been identified. The safety associated with medicinal products of a biological origin is assured by the pharmacovigilance system, which has evolved, but doesn't yet incorporate all of the specific information from this market segment, namely that related to the identification of drugs, and its use - including the prescription and dispensing, given the possibility of interchangeability and substitution. The terminology, information systems and traceability systems aren't entirely appropriate to ensure the safety requirements for therapy with medicinal products of a biological origin. Areas covered: This article aims to identify the prescription and dispensing profiles of reference biological medicines and biosimilars in the EU, and the determinants that support their safe use. Expert opinion: The European pharmacovigilance system must evolve to ensure the safety along all of the biologicals' therapeutic cycle. It must consider the safety for each of the medicines in addition to their safety pattern related to the eventual switching procedure.

  15. [Important issues of biological safety].

    Science.gov (United States)

    Onishchenko, G G

    2007-01-01

    The problem of biological security raises alarm due to the real growth of biological threats. Biological security includes a wide scope of problems, the solution of which becomes a part of national security as a necessary condition for the constant development of the country. A number of pathogens, such as human immunodeficiency virus, exotic Ebola and Lassa viruses causing hemorrhagic fever,rotaviruses causing acute intestinal diseases, etc. were first discovered in the last century. Terrorist actions committed in the USA in 2001 using the anthrax pathogen made the problem of biological danger even more important. In Russian Federation, biological threats are counteracted through the united state policy being a part of general state security policy. The biological Security legislation of Russian Federation is chiefly based on the 1992 Federal Law on Security. On the basis of cumulated experience, the President of Russia ratified Basics of Russian Federation's State Policy for Chemical and Biological Security for the Period through 2010 and Beyond on 4 December, 2003. The document determines the main directions and stages of the state development in the area of chemical and biological security. The Federal target program Russian Federation's National Program for Chemical and Biological Security is being developed, and its development is to be completed soon in order to perfect the national system for biological security and fulfill Basics of Russian Federation's State Policy for Chemical and Biological Security for the Period through 2010 and Beyond, ratified by the President. The new global strategy for control over infectious diseases, presented in the materials of Saint Petersburg summit of the Group of Eight, as well as the substantive part of its elements in Sanitary International Standards, are to a large degree an acknowledgement of the Russian Federation's experience and the algorithm for fighting extremely dangerous infections. This Russia's experience has

  16. Variation of Modal Characteristics of Electrical Cabinet According to the Excitation Level in Impact Hammer Test

    International Nuclear Information System (INIS)

    Cho, Sung Gook; So, Gi Hwan; Kim, Doo Kie

    2010-01-01

    There are many electrical cabinets in nuclear power plants. Safety-related equipment is typically seismic qualified before installation. Seismic qualification of equipment is possible when identifying the accurate dynamic characteristics of the equipment. According to the nature of the cabinet, the dynamic characteristics of the electrical cabinet vary nonlinearly with excitation level. This study analyzed the nonlinear variation of the dynamic properties of an actual cabinet. For the purpose of this study, a seismic monitoring system cabinet was selected as a specimen. The impact hammer tests were conducted to identify a variation of the dynamic characteristics of the specimen by increasing the impulse level. Modal identification technique was used to extract the modal properties of the cabinet from the measurements

  17. Biologics in pediatric psoriasis - efficacy and safety.

    Science.gov (United States)

    Dogra, Sunil; Mahajan, Rahul

    2018-01-01

    Childhood psoriasis is a special situation that is a management challenge for the treating dermatologist. As is the situation with traditional systemic agents, which are commonly used in managing severe psoriasis in children, the biologics are being increasingly used in the recalcitrant disease despite limited data on long term safety. Areas covered: We performed an extensive literature search to collect evidence-based data on the use of biologics in pediatric psoriasis. The relevant literature published from 2000 to September 2017 was obtained from PubMed, using the MeSH words 'biologics', 'biologic response modifiers' and 'treatment of pediatric/childhood psoriasis'. All clinical trials, randomized double-blind or single-blind controlled trials, open-label studies, retrospective studies, reviews, case reports and letters concerning the use of biologics in pediatric psoriasis were screened. Articles covering the use of biologics in pediatric psoriasis were screened and reference lists in the selected articles were scrutinized to identify other relevant articles that had not been found in the initial search. Articles without relevant information about biologics in general (e.g. its mechanism of action, pharmacokinetics and adverse effects) and its use in psoriasis in particular were excluded. We screened 427 articles and finally selected 41 relevant articles. Expert opinion: The available literature on the use of biologics such as anti-tumor necrosis factor (TNF)-α agents, and anti-IL-12/23 agents like ustekinumab suggests that these are effective and safe in managing severe pediatric psoriasis although there is an urgent need to generate more safety data. Dermatologists must be careful about the potential adverse effects of the biologics before administering them to children with psoriasis. It is likely that with rapidly evolving scenario of biologics in psoriasis, these will prove to be very useful molecules particularly in managing severe and recalcitrant

  18. Sources and basic threats of biological safety

    International Nuclear Information System (INIS)

    Nazarova, O.D.

    2010-01-01

    Full text: Biological safety of any state is connected with development of its public protection against biological weapons and opportunity to prevent bio terrorist attacks. That's why in modern social-economic and geo-political conditions, the problem of biological safety strengthening become significant, which is connected with migration process globalization, development of bio-technology and dramatically increased risk of pathogenic germ infections proliferation, which can be used as biological weapon. Despite of undertaken efforts by world community on full prohibition of biological weapon, its proliferation in the world still takes place. Biology revolution during second and third millennium lead to development not only biotechnology but new achievements in medicine, agriculture and other fields of economy, but also created scientific and research preconditions for development of advanced biological means of mass destruction, that make it more attractive for achieving superiority and assigned targets: low developments costs, opportunity to create it by one small laboratory with two-three high qualified specialists bio technologists; tremendous impact effect: one substance gram can contain from one till one hundreds quintillions (10 18 - 10 20 ) active pathogen molecules and in case if they belong to amplificated RNA and DNA, each molecule getting to organism, will multiply and contaminate environment (the last one is its principal difference from chemical weapon); bypass of organism immunological barriers and specific vaccinations; unusual clinic finding, hard diagnosis; weakness of traditional medications and treatment methods; lack of material destruction; opportunity of tight-lipped developments; opportunity of tight-lipped application; opportunity of delayed effect; opportunity of selective influence on specific population (by use of genetic, climatic and cultural specifications of race, nations and nationalities). Above mentioned specifications

  19. [Conceptual bases of biological safety. Part 1].

    Science.gov (United States)

    Onishchenko, G G; Smolenskiĭ, V Iu; Ezhlova, E B; Demina, Iu V; Toporkov, V P; Toprokov, A V; Liapin, M N; Kutyrev, V V

    2013-01-01

    Up to date there is a narrow and broad interpretation of the term biological safety (BS) the world over. In the narrow sense it is defined as availability of international regulations applied to diagnostic, manufacturing, or experimental works with pathogenic biological agents (PBA) in accordance with specified levels of biological hazard and BS. In a broader context it has no national, conceptual, terminological or defying basis. Therewith, establishment of this framework has become the core issue of the study. Investigations have revealed that BS should conceptually cover the whole sphere of sanitary-and-epidemiological welfare as well as related fields such as veterinary-sanitary, phytosanitary provision, ecological safety, environmental conditions (occupational, socio-economic and geopolitical infrastructures, ecological system), and be exercised to prevent and control emergency situations (ES) of biological character. It is demonstrated that this type of ES differs from ES in the sphere of public health care of international concern which is formalized in IHR (2005), in the way that it is characterized by high socio-economic and geopolitical significance of the negative influence on human vital activities, comparable with national and international security hazard. Elaborated is the conceptual, terminological and defying toolkit of the BS broad interpretation (27 terms).

  20. Book review: Safety of Biologics Therapy

    Directory of Open Access Journals (Sweden)

    Robak T

    2017-01-01

    Full Text Available Tadeusz Robak Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, PolandSafety of Biologics Therapy: Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins (Cham, Switzerland: Springer International Publishing; 2016 by Brian A Baldo from the Molecular Immunology Unit, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, and the Department of Medicine, University of Sydney, Australia, is a book that belongs on the shelf of everyone in the field of biologic therapies research and clinical practice. In writing this book, the author’s intention was to produce an up-to-date text book on approved biologic therapies, as far as that is possible in this time of rapidly evolving developments in biotherapeutic research and the introduction of new and novel agents for clinical use.The monograph comprises 610 pages in 13 chapters, each including a summary and further reading suggestions. All chapters include a discussion of basic and clinical material. Well-designed, comprehensive tables and color figures are present throughout the book. The book itself examines the biologic products that have regulatory approval in the USA and/or European Union and that show every indication of remaining important therapies. It covers in great detail all the latest work on peptide hormones and enzymes, monoclonal antibodies, fusion proteins, and cytokine therapies. Beyond that, it also presents the latest information on blood coagulation proteins, vaccines, botulinum neurotoxins, and biosimilars. 

  1. Biological Safety of Fish (Tilapia Collagen

    Directory of Open Access Journals (Sweden)

    Kohei Yamamoto

    2014-01-01

    Full Text Available Marine collagen derived from fish scales, skin, and bone has been widely investigated for application as a scaffold and carrier due to its bioactive properties, including excellent biocompatibility, low antigenicity, and high biodegradability and cell growth potential. Fish type I collagen is an effective material as a biodegradable scaffold or spacer replicating the natural extracellular matrix, which serves to spatially organize cells, providing them with environmental signals and directing site-specific cellular regulation. This study was conducted to confirm the safety of fish (tilapia atelocollagen for use in clinical application. We performed in vitro and in vivo biological studies of medical materials to investigate the safety of fish collagen. The extract of fish collagen gel was examined to clarify its sterility. All present sterility tests concerning bacteria and viruses (including endotoxin yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the http://dx.doi.org/10.13039/501100003478 Ministry of Health, Labour and Welfare. The present study demonstrated that atelocollagen prepared from tilapia is a promising biomaterial for use as a scaffold in regenerative medicine.

  2. Biological safety of fish (tilapia) collagen.

    Science.gov (United States)

    Yamamoto, Kohei; Igawa, Kazunari; Sugimoto, Kouji; Yoshizawa, Yuu; Yanagiguchi, Kajiro; Ikeda, Takeshi; Yamada, Shizuka; Hayashi, Yoshihiko

    2014-01-01

    Marine collagen derived from fish scales, skin, and bone has been widely investigated for application as a scaffold and carrier due to its bioactive properties, including excellent biocompatibility, low antigenicity, and high biodegradability and cell growth potential. Fish type I collagen is an effective material as a biodegradable scaffold or spacer replicating the natural extracellular matrix, which serves to spatially organize cells, providing them with environmental signals and directing site-specific cellular regulation. This study was conducted to confirm the safety of fish (tilapia) atelocollagen for use in clinical application. We performed in vitro and in vivo biological studies of medical materials to investigate the safety of fish collagen. The extract of fish collagen gel was examined to clarify its sterility. All present sterility tests concerning bacteria and viruses (including endotoxin) yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the Ministry of Health, Labour and Welfare of Japan. The present study demonstrated that atelocollagen prepared from tilapia is a promising biomaterial for use as a scaffold in regenerative medicine.

  3. 24 CFR 3280.204 - Kitchen cabinet protection.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Kitchen cabinet protection. 3280... Kitchen cabinet protection. (a) The bottom and sides of combustible kitchen cabinets over cooking ranges... is designed for the future installation of a cooking range, the metal hood and cabinet protection...

  4. Russia's science minister keeps cabinet post

    CERN Multimedia

    1999-01-01

    Mikhail Kirpichnikov, minister for science and technology has kept his post in the cabinet of the new prime minister Sergei Stepashin. Yevgeniy Adamov also remains as minister of atomic energy (2 paragraphs).

  5. Evaluation of seismic characteristics and structural integrity for the cabinet of HANARO seismic monitoring analysis system

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jeong Soo; Yoon, Doo Byung

    2003-06-01

    The HANARO SMAS(Seismic Monitoring Analysis System) is classified as Non-Nuclear Safety(NNS), seismic category I, and quality class T. It is required that this system can perform required functions, which are to preserve its structural integrity during and after an OBE or SSE. In this work, the structural integrity and seismic characteristics of the cabinet of the newly developed SMAS have been estimated. The most parts of the cabinet are identically designed with those of Yonggwhang and Gori Nuclear Power Plants(NPPs), unit 1 that successfully completed the required seismic qualification tests. The structure of the cabinet of the SMAS is manufactured by the manufacturer of the cabinet of Yonggwhang and Gori NPPs. To evaluate the seismic characteristics of the SMAS, the RRS(Required Response Spectra) of the newly developed cabinet are compared with those of Yonggwhang and Gori NPPs, unit 1. In addition, natural frequencies of the cabinet of HANARO, Yonggwhang, and Gori NPPs were measured for the comparison of the seismic characteristics of the installed cabinets. In case of HANARO, the bottom of the cabinet is welded to the base plate. The base plate is fixed to the concrete foundation by using anchor bolts. For the evaluation of the structural integrity of the welding parts and the anchor bolts, the maximum stresses and forces of the welding parts and the anchor bolts due to seismic loading are estimated. The analysis results show that maximum stresses and forces are less than the allowable limits. This new SMAS is operating at HANARO instrument room to acquire and analyze the signal of earthquake.

  6. Children: Oklahoma's Investment in Tomorrow '96. Preliminary Report: Agency Budget by Cabinet.

    Science.gov (United States)

    Oklahoma Commission on Children and Youth, Oklahoma City.

    This report presents preliminary Oklahoma state agency budget summaries for all programs serving children in the Departments of Administration, Agriculture, Commerce, Education, Energy, Health and Human Services, Human Resources, Safety and Security, Tourism and Recreation, and Veterans Affairs. The budget figures are organized by cabinet and…

  7. Evaluation of modal properties of cabinet type instrument of nuclear power plant

    International Nuclear Information System (INIS)

    Cho, Y. H.; Park, H. K.; Cho, S. K.

    1999-01-01

    The seismic qualification of safety-related equipment is usually achieved through analysis and testing. Analysis method is preferably adopted for structurally simple equipments which are easy to be mathematically modeled. However, even for relatively complex equipments, analysis method is occasionlly used for computing the input motion or supporting information for the component test followed. Electrical cabinet is a typical example for which analysis method is combinedly used with test to get modal properties of the enclosing cabinet structure. In this paper, with respect to a typical cabinet-type structure(instrumentation cabinet of nuclear power plant) a comparative study has been performed between three different state-of-the-art modeling techniques: lumped mass model, frame model, and FEM modal. From the study results, it has been found that the modal properties of the cabinet-type structure in the elastic behavior range can be reasonably computed through any type of modeling techniques in the practice with slight modification of model properties to get better accuracy. However, it needs additional modeling techniques to get reasonable results up to nonlinear range

  8. Biologic Therapy in Inflammatory Eye Conditions (Ophtalmology): Safety Profile.

    Science.gov (United States)

    Neri, Piergiorgio; Arapi, Ilir; Nicolai, Michele; Pirani, Vittorio; Saitta, Andrea; Luchetti, Michele M; Giovannini, Alfonso; Mariotti, Cesare

    2016-01-01

    Non-infectious uveitis can be a potentially sight threatening disease. Very recently, therapeutic strategies have turned towards a new methodology, which includes biologic agents. The introduction of biologic drugs has started a Copernican revolution in ophthalmology: biologic therapies represent a revolutionary option for those patients who present non-responder, sight threatening uveitis. The availability of these therapies has improved the uveitis outcome. The present review shows the most relevant medical literature on biologic agents in ophthalmology, such as tumor necrosis factor blockers, anti-interleukins and other related biologics. Several papers reported the efficacy of biologic agents in a large number of refractory uveitides, which suggest a promising role of biologic drugs for selected cases. On the other hand, the medical literature does not have consistent numbers yet, which hopefully will validate the promising preliminary results. Biologic agents are not only promising drugs for the treatment of nonresponder uveitis, but also they show an apparently favourable safety profile, although several topics remain unsolved: it is still not clear when commencing the treatment, which agent to choose, and the length of biologic therapy. Moreover, the high costs and the still not clear safety profile have very often limited their use only for severe, non-responder uveitis in highly specialized uveitis centres.

  9. Safety, security, and serving the public interest in synthetic biology.

    Science.gov (United States)

    Gronvall, Gigi Kwik

    2018-03-21

    This article describes what may be done by scientists and by the biotechnology industry, generally, to address the safety and security challenges in synthetic biology. Given the technical expertise requirements for developing sound policy options, as well as the importance of these issues to the future of the industry, scientists who work in synthetic biology should be informed about these challenges and get involved in shaping policies relevant to the field.

  10. Biological and haematological safety profile of oral amodiaquine ...

    African Journals Online (AJOL)

    Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. JJ Massaga, JP Lusingu, R Makunde, HM Malebo, MM Chile, JA Akida, MM Lemnge, AM Rønn, TG Theander, IC Bygbjerg, AY Kitua ...

  11. Safety aspects in biotechnology. Classifications and safety precautions for handling of biological agents.

    Science.gov (United States)

    Frommer, W; Krämer, P

    1990-07-01

    The term "biotechnology" is today used much more widely than 10 years ago. According to the modern definition, biotechnology represents the "conveyor belt" which brings advances in the fields of molecular biology, cell biology, molecular genetics, microbiology, biochemistry and process engineering, etc., into the areas of application. It is attempted to indicate the development of safety standards concerning biotechnology. This development is in a state of flux, and the finding that the risks in handling r-DNA organisms are not larger than those arising when handling the known pathogens is becoming more accepted. Accordingly, these r-DNA organisms can also be classified into the known risk groups I-IV and handled under the corresponding safety conditions according to this classification: In the laboratory under the laboratory safety measures L1-L4 described in the BMFT-Guidelines or guidelines for occupational health and hygiene (UVV Biotechnologie) and on a process scale under the process safety measures described in the OECD report. The discussion of aspects on waste disposal, education/training and public perception in the field of biological safety completes the report.

  12. Does Right or Left Matter? Cabinets, Credibility and Fiscal Adjustments

    OpenAIRE

    Jose Tavares

    2000-01-01

    This paper uses the widely held assumption that left-wing cabinets prefer a larger size of government than right-wing cabinets to answer the question: does the pair cabinet ideology - fiscal action affect the persistence of fiscal adjustments? For a panel of OECD countries from 1960 to 1995, we find that left and right-wing cabinets are partisan in the expected way, namely, when cutting the deficit, the left relies on tax increases and the right on spending cuts. Our testable hypothesis is th...

  13. 21 CFR 880.6100 - Ethylene oxide gas aerator cabinet.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ethylene oxide gas aerator cabinet. 880.6100... Miscellaneous Devices § 880.6100 Ethylene oxide gas aerator cabinet. (a) Identification. An ethyene oxide gas... required to remove residual ethylene oxide (ETO) from wrapped medical devices that have undergone ETO...

  14. Biologics, Pharmacovigilance, and Patient Safety: It's All in the Name.

    Science.gov (United States)

    Stevenson, James G; Green, Larry

    2016-08-01

    The most appropriate naming convention for biologics and biosimilars has been an area of significant debate. The ultimate decision will have an impact on patient safety, pharmacovigilance program effectiveness, and, potentially, the overall adoption of biosimilars in the United States. This article reviews some of the advantages and disadvantages of various naming approaches. For clarity in communication, optimal pharmacovigilance, and patient safety, it is recommended that biosimilars be named with a common USAN (United States Adopted Name) with the reference product, along with a suffix that is memorable, such as one associated with the original manufacturer of the product. This approach supports the FDA's mission of protecting patient safety and public health, while minimizing the possibility of inadvertent switching of products and facilitating effective pharmacovigilance. No funding supported the writing of this article. Stevenson reports consulting fees from Amgen, Inc., AbbVie, and Pfizer and is employed by Visante. Green is employed by and owns stock in Amgen, Inc. Article concept was contributed primarily by Stevenson, along with Green. The manuscript was written and revised primarily by Stevenson, along with Green. Both authors contributed equally to data interpretation.

  15. NULIFE - Project CABINET. RPV Assessment under Consideration of Constraint and Warm Pre-Stress Effects

    International Nuclear Information System (INIS)

    Obermeier, F.; Nicak, Tomas; Keim, Elisabeth; Fekete, Tamas; Scibetta, Marc; Planman, Tapio; Laukkanen, Anssi; Carcia, Carlos Cueto-Felgueroso; Sattari-Far, Iradj

    2012-01-01

    At the moment, nuclear power plant regulators do not predominantly consider constraint and biaxial effects in their concepts for failure assessment of nuclear components. The warm pre-stressing (WPS) effect is only partly considered in some assessment procedures and codes. There is also a lack of a harmonized treatment of these effects in the safety assessment of European plants. This paper introduces the project CABINET (Constraint and Biaxial Loading Effects and their Interactions Considering Thermal Transients) which is a collaborative project under the EU's Network of Excellence NULIFE. The overall objective of CABINET is to investigate and understand constraint, biaxial loading and WPS effects in terms of a clearly defined application window, especially in the light of long term operation. The focus lies on already available experimental data and methodologies. The intention is to provide recommendations for a harmonized application of those effects in European nuclear safety assessment. The possibility to include different level of analysis depending on input data and acceptance of National Regulatory Body is also being evaluated. Although the CABINET project is not completed yet, it has been found that it is possible to rationalize the different existing codes. (author)

  16. Evolution of approaches to viral safety issues for biological products.

    Science.gov (United States)

    Lubiniecki, Anthony S

    2011-01-01

    CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Approaches to viral safety issues for biological products have evolved during the past 50+ years. The first cell culture products (viral vaccines) relied largely on the use of in vitro and in vivo virus screening assays that were based upon infectivity of adventitious viral agents. The use of Cohn fractionation and pasteurization by manufacturers of plasma derivatives introduced the concepts that purification and treatment with physical and chemical agents could greatly reduce the risk of viral contamination of human albumin and immunoglobulin products. But the limitations of such approaches became clear for thermolabile products that were removed early in fractionation such as antihemophilic factors, which transmitted hepatitis viruses and HIV-1 to some product recipients. These successes and limitations were taken into account by the early developers of recombinant DNA (rDNA)-derived cell culture products and by regulatory agencies, leading to the utilization of cloning technology to reduce/eliminate contamination due to human viruses and purification technologies to physically remove and inactivate adventitious and endogenous viruses, along with cell banking and cell bank characterization for adventitious and endogenous viruses, viral screening of biological raw materials, and testing of cell culture harvests, to ensure virus safety. Later development and incorporation of nanofiltration technology in the manufacturing process provided additional assurance of viral clearance for safety of biotechnology products. These measures have proven very effective at preventing iatrogenic infection of recipients of biotechnology products; however, viral contamination of production cell cultures has

  17. Automated energy conserving cover for refrigerated cabinet access openings

    International Nuclear Information System (INIS)

    Ibrahim, F.F.

    1984-01-01

    An automatically operated flexible barrier cover for the access openings of refrigerated display cabinets. The barrier cover limits the contact between the refrigerated air within the cabinet and the ambient air. The barrier cover can be moved over the access opening during non-customer use time periods when the retail food outlet is closed. The barrier cover can be arranged as a unitary assembly which can be manufactured and sold separately from the display cabinet as a retrofit device to effect energy savings. The flexible barrier cover can be stored in a reeled-up position or can be arranged as a folded flexible barrier which can be fanned out across the access opening. Various traction means are provided for moving the flexible barrier across the access opening

  18. Biological effects of radiation human health and safety

    International Nuclear Information System (INIS)

    1977-05-01

    The biological hazards of nuclear energy usage are a growing source of public concern. The medical profession may well be expected to contribute to public debate on the issue. This document, therefore, attempts a balanced review of the known and suspected human biological consequences of exposure to different types of ionizing radiation, emphasizing in particular the nuclear industry

  19. Study on the Reduction of Acetic Acid from Cabinets for Microfilms

    OpenAIRE

    佐野, 千絵; 古田嶋, 智子; 井上, さやか; 津田, 徹英; 呂, 俊民

    2012-01-01

    Concentration of acetic acid in cabinets, film storage and adjacent room were measured. Two cabinets were filled with acetic acid generated from aged microfilms. Absorbents were placed in one of the cabinets to remove acetic acid. It was confirmed thatconcentration of acetic acid decreased one week after setting the absorbents. Concentration in the other cabinet in which acetic-acid-absorbents were not placed remained high. From this result, it may be said that the absorbents were effective i...

  20. EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology

    DEFF Research Database (Denmark)

    Dixon, William G; Carmona, Loreto; Finckh, Axel

    2010-01-01

    upon safety data generated from observational drug registers makes it important to convert the lessons learned from such registers into recommendations for rheumatologists embarking upon the establishment of future registers, or analysing and reporting from new and existing registers.......The introduction of biological therapies for the treatment of rheumatic diseases has drawn attention to the limitations of traditional means of assessing drug safety. Consequently, a series of European academic biologics registers dedicated to this task have been established. Increasing reliance...

  1. Home Medication Cabinets and Medication Taking Behavior of the Staffs in a University in China

    Science.gov (United States)

    Xue, Chengbin; Ye, Juan; Dong, Yuzhen; Xu, Chunmei

    2018-01-01

    Background: A growing sum of medicines is stored in home medication cabinets in China, with the behavior of self-medication increasing. Although responsible self-medication can help prevent and treat ailments that do not need professional consultation, it bears the risk of misuse of medicines issued on prescription due to inadequate prescription medicine administration. Objective: The objective of this study was to investigate the condition and safety of medication storage and intended self-medication in a University in China. Method: The study was conducted over 10 month period (May 2015-March 2016) and involved a random sample of households. The questionnaire survey and personal insight into household medicine supplies was performed by a team of trained pharmacy staffs. Interviewees (N = 398, aged 16-88 y) were visited door to door and the home medication cabinets were catalogued after the participants were interviewed. Results: The majority (89.71%) households have home medicine cabinets. The total number of medicine items in the 398 households was 5600, with a median of 14 per household. The most frequently encountered categories of registered medicines were cough and cold medcines (47.8%), antibacterials for systemic use (30.0%), topical products for joint and muscular pain(26.1%), vitamins (23.2%), medication for functional gastrointestinal disorders (23.2%), oral and external forms have not kept separately(55.1%). The most treatment related problems recorded were curative effect not ideal (57.9%). 68% of the sample population would choose doctors as medication consultation object about medicines purchased. Conclusion: Large sum of medicines were found per household, with a high prevalence of cough and cold medcines. Public services in China, mainly government and health organizations, need put more effort on educating people on how to store medicines, as well as finding a way to raise awareness of the public in promoting behavioral change about medication

  2. 21 CFR 1020.40 - Cabinet x-ray systems.

    Science.gov (United States)

    2010-04-01

    ...) RADIOLOGICAL HEALTH PERFORMANCE STANDARDS FOR IONIZING RADIATION EMITTING PRODUCTS § 1020.40 Cabinet x-ray...-radiation. (i) During an exposure or preset succession of exposures of one-half second or greater duration, the means provided shall enable the operator to terminate the exposure or preset succession of...

  3. The WWW Cabinet of Curiosities: A Serendipitous Research Tool

    Science.gov (United States)

    Arnold, Josie

    2012-01-01

    This paper proposes that the WWW is able to be fruitfully understood as a research tool when we utilise the metaphor of the cabinet of curiosities, the wunderkammer. It unpeels some of the research attributes of the metaphor as it reveals the multiplicity of connectivity on the web that provides serendipitous interactions between unexpected…

  4. Market opportunities for kitchen cabinets made from Alaska hardwoods: a synthesis and review of recent research.

    Science.gov (United States)

    David L. Nicholls; Maria C. Stiefel

    2007-01-01

    The kitchen cabinet industry has shown significant growth recently, with expanding residential markets, new cabinet styles, and larger kitchens. This industry represents an opportunity for small Alaska wood producers to create high-value secondary products. In response to recent trends in kitchen cabinet manufacturing and the need to identify opportunities for...

  5. The wood household furniture and kitchen cabinet industries: a contrast in fortune

    Science.gov (United States)

    William G. Luppold; Matthew S. Bumgardner

    2009-01-01

    In 1977, the value of wood household furniture shipments from domestic manufacturers exceeded kitchen cabinet shipments by 170 percent; conversely, in 2006 shipments of cabinets exceeded shipments of furniture by 78 percent. The most apparent reason for the decrease in domestic furniture shipments is the increase in furniture imports, whereas cabinet demand has...

  6. Establishing a national biological laboratory safety and security monitoring program.

    Science.gov (United States)

    Blaine, James W

    2012-12-01

    The growing concern over the potential use of biological agents as weapons and the continuing work of the Biological Weapons Convention has promoted an interest in establishing national biological laboratory biosafety and biosecurity monitoring programs. The challenges and issues that should be considered by governments, or organizations, embarking on the creation of a biological laboratory biosafety and biosecurity monitoring program are discussed in this article. The discussion focuses on the following questions: Is there critical infrastructure support available? What should be the program focus? Who should be monitored? Who should do the monitoring? How extensive should the monitoring be? What standards and requirements should be used? What are the consequences if a laboratory does not meet the requirements or is not willing to comply? Would the program achieve the results intended? What are the program costs? The success of a monitoring program can depend on how the government, or organization, responds to these questions.

  7. Detecting Fan Faults in refrigerated Cabinets

    DEFF Research Database (Denmark)

    Thybo, C.; Rasmussen, B.D.; Izadi-Zamanabadi, Roozbeh

    2002-01-01

    Fault detection in supermarket refrigeration systems is an important topic due to both economic and food safety reasons. If faults can be detected and diagnosed before the system drifts outside the specified operational envelope, service costs can be reduced and in extreme cases the costly discar...

  8. EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology

    DEFF Research Database (Denmark)

    Dixon, William G; Carmona, Loreto; Finckh, Axel

    2010-01-01

    The introduction of biological therapies for the treatment of rheumatic diseases has drawn attention to the limitations of traditional means of assessing drug safety. Consequently, a series of European academic biologics registers dedicated to this task have been established. Increasing reliance...

  9. Evaluation of DoD Biological Safety and Security Implementation

    Science.gov (United States)

    2016-04-27

    methods, facilities, and equipment for managing infectious materials in the laboratory where they are handled or maintained.7 • Risk assessment: considers...2009, p. 31. 25 Laboratories with microbiological practices, safety equipment , and facility safeguards for handling Biosafety level 3 (BSL-3...animal, a plant, or another living organism; deterioration of food, water, equipment , supplies, or material of any kind; or deleterious alteration

  10. CFD Parametric Studies for Global Performance Improvement of Open Refrigerated Display Cabinets

    Directory of Open Access Journals (Sweden)

    Pedro Dinis Gaspar

    2012-01-01

    Full Text Available A detailed CFD modelling of an open refrigerated display cabinet has been formulated in a previous study. Some modifications are introduced in order to perform parametric studies dealing with low-cost geometrical and functional characteristics for improvement of the global performance and energy efficiency. The parametric studies are devoted to the analysis of the thermal response and behaviour inside the food conservation space influenced by (1 air flow rate through the evaporator heat exchanger; (2 air curtain behaviour; (3 hole dimensions and distribution of the back panel; (4 discharge and return grilles angles; and (5 flow deflectors inside the internal duct. The analysis of the numerical predictions from the parametric studies allows the development of an optimized model for the conception of an open refrigerated display cabinet with a more adequate configuration. The numerical predictions of the optimized model show lower product temperature and reduced electrical energy consumption, allowing the improvement of the food safety and the energy rationalization of the refrigeration equipment.

  11. Long-term safety of biologics in the treatment of psoriasis

    Directory of Open Access Journals (Sweden)

    Panchal MR

    2013-12-01

    Full Text Available Manisha R Panchal,1 Helen Coope,2 D John McKenna,3 Anton B Alexandroff31Department of Dermatology, Sherwood Forest Hospitals, Kingsmill Hospital, Nottinghamshire, 2Novartis Pharmaceuticals UK Ltd, West Sussex, 3Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UKAbstract: Biologics are novel and important agents in the treatment of severe psoriasis. These agents block specific molecular steps in the inflammatory cascade, thereby reducing activation and proliferation of keratinocytes. Prescreening for biologic agents and careful monitoring of patients is important. There are four biologics currently licensed and used in the treatment of psoriasis in the European Union. This is an evidence-based review examining clinical trials and focusing on the long-term safety data for four biologic agents. Current British Association of Dermatology guidance for the use of biologics in psoriasis and guidelines on the management of psoriasis from the National Institute for Health and Clinical Excellence have been used. Advances on safety information since 2009 in clinical trials are reviewed. The results show that overall there is no statistical significance in the incidence of adverse effects of biologics versus placebo. However, there are serious adverse effects that are reported for biologics that need to be assessed for and addressed promptly. Results of studies discussing major adverse cardiovascular events are also reviewed.Keywords: psoriasis, biologic agents, safety profile, major cardiovascular events

  12. Practices and Exploration on Competition of Molecular Biological Detection Technology among Students in Food Quality and Safety Major

    Science.gov (United States)

    Chang, Yaning; Peng, Yuke; Li, Pengfei; Zhuang, Yingping

    2017-01-01

    With the increasing importance in the application of the molecular biological detection technology in the field of food safety, strengthening education in molecular biology experimental techniques is more necessary for the culture of the students in food quality and safety major. However, molecular biology experiments are not always in curricula…

  13. Measurement of the transient shielding effectiveness of shielding cabinets

    Directory of Open Access Journals (Sweden)

    H. Herlemann

    2008-05-01

    Full Text Available Recently, new definitions of shielding effectiveness (SE for high-frequency and transient electromagnetic fields were introduced by Klinkenbusch (2005. Analytical results were shown for closed as well as for non closed cylindrical shields. In the present work, the shielding performance of different shielding cabinets is investigated by means of numerical simulations and measurements inside a fully anechoic chamber and a GTEM-cell. For the GTEM-cell-measurements, a downscaled model of the shielding cabinet is used. For the simulations, the numerical tools CONCEPT II and COMSOL MULTIPHYSICS were available. The numerical results agree well with the measurements. They can be used to interpret the behaviour of the shielding effectiveness of enclosures as function of frequency. From the measurement of the electric and magnetic fields with and without the enclosure in place, the electric and magnetic shielding effectiveness as well as the transient shielding effectiveness of the enclosure are calculated. The transient SE of four different shielding cabinets is determined and discussed.

  14. Application Software for the Cabinet Operator Module of the Reactor Protection System

    International Nuclear Information System (INIS)

    Lee, Hyun-Chul; Jung, Hae-Won; Lee, Sung-Jin; Koo, Young-Ho; Kim, Seong-Tae; Kwak, Tae-Kil; Jin, Kyo-Hong

    2006-01-01

    A reactor protection system (RPS) plays the roles of generating the reactor trip signal and the engineered safety features (ESF) actuation signal when the monitored plant processes reach predefined limits. A Korean project group, so-called KNICS (Korean Nuclear I and C System), is developing a new digitalized RPS and the Cabinet Operator Module (COM) of the RPS which is used for the RPS integrity testing and monitoring by equipment operators. A flat panel display (FPD) with a touch screen capability is provided as a main user interface for the RPS. This paper shows the application software developed for the COM FPD. Equipment operators can monitor the status of the RPS and carry out various tests to verify system functions by means of the application software. A qualified hardware and software development environment are used to develop the application software

  15. Safety, efficacy, and drug survival of biologics and biosimilars for moderate-to-severe plaque psoriasis

    DEFF Research Database (Denmark)

    Egeberg, A; Ottosen, M B; Gniadecki, R

    2018-01-01

    for all drugs except for adalimumab and secukinumab. Adverse events (predominantly infections) were most frequent for secukinumab and showed an increased (albeit low) incidence of cardiovascular events compared with the other agents. CONCLUSIONS: Ustekinumab was associated with the highest drug survival......BACKGROUND: Real-life data on newer biologic and biosimilar agents for moderate-to-severe psoriasis are lacking. OBJECTIVES: To examine safety, efficacy, and time to discontinuation (drug survival) of biologics (adalimumab, etanercept, infliximab, secukinumab, and ustekinumab) and compare...

  16. Sound Radiation from a Loudspeaker Cabinet using the Boundary Element Method

    DEFF Research Database (Denmark)

    Fernandez Grande, Efren

    Ideally, the walls of a loudspeaker cabinet are rigid. However, in reality, the cabinet is excited by the vibration of the loudspeaker units and by the acoustic pressure inside the cabinet. The radiation of sound caused by such vibration can influence the overall performance of the loudspeaker......, in some cases becoming clearly audible. The aim of this study is to provide a tool that can evaluate the contribution from the cabinet to the overall sound radiated by a loudspeaker. The specific case of a B&O Beolab 9 early prototype has been investigated. An influence by the cabinet of this prototype...... had been reported, based on subjective testing. This study aims to detect the reported problem. The radiation from the cabinet is calculated using the Boundary Element Method. The analysis examines both the frequency domain and the time domain characteristics (in other words, the steady state response...

  17. Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis

    DEFF Research Database (Denmark)

    Tarp, Simon; Amarilyo, Gil; Foeldvari, Ivan

    2016-01-01

    OBJECTIVE: To define the optimal biologic agent for systemic JIA (sJIA) based on safety and efficacy data from a randomized controlled trial (RCT). METHODS: Through a systematic literature search, sJIA RCTs evaluating biologic agents were identified. The primary efficacy outcome was defined as a 30......, this meta-analysis of short-term RCTs presents empirical evidence that canakinumab and tocilizumab are more effective than rilonacept. Biologic agents in sJIA seem safe and comparable with respect to SAE risk in the short term....

  18. Functional medicine cabinet for the simulation studio at Lahti University of Applied Sciences

    OpenAIRE

    Gustafsson, Emilia; Virtanen, Essi; Tuikkanen, Joe

    2016-01-01

    The aim of this functional thesis was to create a more authentic simulation environment for the faculty of social and health care at Lahti University of Applied Sciences by updating the contents of the already existing medicine cabinet in the simulation studio. The purpose was to enable the nursing students to familiarize themselves with a medicine cabinet that would be as close as possible to the cabinets found in clinical placements and future work places. A pharmacology teacher in Lah...

  19. Safety Assessment and Biological Effects of a New Cold Processed SilEmulsion for Dermatological Purpose

    Directory of Open Access Journals (Sweden)

    Sara Raposo

    2013-01-01

    Full Text Available It is of crucial importance to evaluate the safety profile of the ingredients used in dermatological emulsions. A suitable equilibrium between safety and efficacy is a pivotal concern before the marketing of a dermatological product. The aim was to assess the safety and biological effects of a new cold processed silicone-based emulsion (SilEmulsion. The hazard, exposure, and dose-response assessment were used to characterize the risk for each ingredient. EpiSkin assay and human repeat insult patch tests were performed to compare the theoretical safety assessment to in vitro and in vivo data. The efficacy of the SilEmulsion was studied using biophysical measurements in human volunteers during 21 days. According to the safety assessment of the ingredients, 1,5-pentanediol was an ingredient of special concern since its margin of safety was below the threshold of 100 (36.53. EpiSkin assay showed that the tissue viability after the application of the SilEmulsion was 92 ± 6% and, thus considered nonirritant to the skin. The human studies confirmed that the SilEmulsion was not a skin irritant and did not induce any sensitization on the volunteers, being safe for human use. Moreover, biological effects demonstrated that the SilEmulsion increased both the skin hydration and skin surface lipids.

  20. Optimization of the Document Placement in the RFID Cabinet

    Directory of Open Access Journals (Sweden)

    Kiedrowicz Maciej

    2016-01-01

    Full Text Available The study is devoted to the issue of optimization of the document placement in a single RFID cabinet. It has been assumed that the optimization problem means the reduction of archivization time with respect to the information on all documents with RFID tags. Since the explicit form of the criterion function remains unknown, for the purpose of its approximation, the regression analysis method has been used. The method uses data from a computer simulation of the process of archiving data about documents. To solve the optimization problem, the modified gradient projection method has been used.

  1. Relay studies - existing data, current testing and cabinet amplification

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.; Kassir, M.; Pepper, S.

    1989-01-01

    The seismic fragility of most electrical equipment is governed by the malfunction of relays. This paper discusses the combined study being performed at BNL by evaluating existing fragility test data, conducting a new relay test program and estimating the cabinet amplification at relay locations. Existing test data for relays have been collected and evaluated at BNL. The data base consists of results from a wide variety of test programs - single frequency, single axis, multifrequency, multiaxis tests. For most relays, the non-operating condition controls the chatter fragility limit. In order to characterize the effect of various parameters on the relay seismic capacity, a test program has been initiated at BNL. Selected test specimens will be tested to determine the influence of frequency of vibration, direction of motion, adjustments of relay parts, among others, on the relay capacities. The amplification study involves computing dynamic amplification factors at various device locations in motor control center and switchgear cabinets. Fragility and high level qualification data have been used for this purpose. This paper includes a summary of the amplification results. 4 refs., 6 figs., 1 tab

  2. CIFAC '92: First International Symposium on Computers in Furniture and Cabinet

    Science.gov (United States)

    Janice K. Wiedenbeck

    1992-01-01

    (Book Review) The First International Symposium on Computers in Furniture and Cabinet Manufacturing was sponsored by the Wood Machining Institute in cooperation with Furniture Design and Manufacturing Magazine. The symposium was designed to ãprovide an international forum for the exchange of the latest information on the use of computers in furniture and cabinet...

  3. RESEARCH OF QUALITY, SAFETY AND CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES OF FOOD RED BEET

    OpenAIRE

    Gorash E. Y.; Victorova E. P.; Kupin G. A.; Aleshin V. N.; Lisovoy V. V.

    2015-01-01

    The article presents results of research of quality, safety and content of biologically active substances of food red beet roots of Bordo 237 variety, grown in the Krasnodar region in 2014. On the basis of the research carried out it was established, that there are carbohydrates, proteins, organic acids and mineral substances in the food red beet roots of Bordo 237 variety. Food red beet roots are a source of dietary fibers (pectin, protopectin, hemicelluloses and cellulose), possessing antit...

  4. [Biological safety of nanomaterials: the opportunity and challenge of preventive medicine].

    Science.gov (United States)

    Zhao, Yuliang

    2015-09-01

    Nanotechnology, as a newly arisen technology, does not only benefit people, but also become one of the inevitable threats to public health due to the widely application of nanomaterials. The safety evaluation of nanomaterials has become one of the hottest research topics in the 21st century, which provides opportunities and challenges in the field of preventive medicine once in a blue moon. Although the history of development in the safety assessment of nanomaterials is just over twenty years, the achievements could not be underestimated. This paper summarized the research of nano biological, predicted the directions for future research, and proposed several recommendations, based on which, we hope it can promote the sustainable development safety in China.

  5. Savoirs mondains, savoirs savants : les femmes et leurs cabinets de curiosités au siècle des Lumières

    Directory of Open Access Journals (Sweden)

    Adeline Gargam

    2010-01-01

    Full Text Available Dans la France des Lumières, la culture de la curiosité est un phénomène de mode mais surtout un jeu social et intellectuel. La présente étude entend retracer l’histoire d’une trentaine de cabinets féminins de curiosité tenus à cette époque. Des femmes fortunées de l’aristocratie et de la bourgeoisie parisienne et provinciale ont alors constitué sous l’emprise de leur libido sciendi des cabinets d’alchimie, de minéralogie, de physique‑chimie, d’histoire naturelle et d’anatomie naturelle et artificielle. Ces cabinets obéissent à une typologie particulière. Il en existe deux catégories : les cabinets d’amateurs, constitués pour la parade et le spectacle des visiteurs et fonctionnant comme de véritables écoles de plaisirs intellectuels et éducatifs ; les cabinets à finalité scientifique et didactique, formés par des savantes expérimentées qui se livrent dans leurs laboratoires à des recherches personnelles et expérimentales au nom des progrès de la science médicale et de l’instruction publique. La réflexion porte aussi sur le fonctionnement de ces cabinets privés de curiosité, particulièrement sur leur mode de constitution, leur décor intérieur ainsi que sur le contenu des collections qui nécessitaient certaines techniques d’organisation, d’acquisition et de conservation communes à celles de leurs homologues masculins.During the Enlightenment in France, curiosity culture constituted both a fashion and an intellectual and social game.  This article explores thirty cabinets of  curiosities run by women during this period. Wealthy women from the Parisiain and provincial aristocracy and middle classes organized cabinets in alchemy, mineralogy, physics and chemistry, natural history and biology studies. These cabinets can be divided into two distinct categories. The first represented amateur interests; they were developed for show and served as schools for intellectual and

  6. The Biological Safety of Stainless Steel Needles Used in Warm-Needling

    Directory of Open Access Journals (Sweden)

    Sabina Lim

    2010-01-01

    Full Text Available Warm-needling (also called thermo-acupuncture is a combination of acupuncture and moxibustion. Due to the intense heat involved, there have been concerns over the biological safety of the acuneedles used in the treatment. This paper reports two phases of a safety test. For a preliminary test, we compared the temperature change patterns of stainless steel (SS304 needles and traditional gold alloy needles, which have been increasingly replaced by the former. To verify the effects of the presence of coating materials, the main test involved three different kinds of SS304: silicone-coated, salicylic acid-coated and non-coated needles. Each group of needles was tested for pH level, heavy metals and UV absorbance spectrum along with biological tests on the cytotoxicity and hemolysis of the needle. All the tests on the extractants from the needles were negative. In the biological tests, each test result showed a significant difference from the positive control samples, while no significant difference was observed compared with the negative control samples. In the hemolysis tests, all samples satisfied the Korean Government Standards. All the results suggest that SS304 needles are biologically safe to be used in warm-needling, though they can be improved to perform as well as the gold alloy needles in terms of temperature fluctuations.

  7. Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability

    Directory of Open Access Journals (Sweden)

    Farahnik B

    2016-07-01

    Full Text Available Benjamin Farahnik,1 Viraat Patel,2 Kourosh Beroukhim,3 Tian Hao Zhu,4 Michael Abrouk,2 Mio Nakamura,5 Rasnik Singh,3 Kristina Lee,5 Tina Bhutani,5 John Koo5 1University of Vermont College of Medicine, Burlington, VT; 2School of Medicine, University of California, Irvine, 3David Geffen School of Medicine, University of California, Los Angeles, 4University of Southern California Keck School of Medicine, Los Angeles, 5Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, CA, USA Background: The efficacy and safety of biologic and phototherapy in treating moderate-to-severe psoriasis is well known. However, some patients may not respond well to biologic agents or phototherapy on their own and may require combination therapy. Skillfully combining a biologic agent and phototherapy may provide an additive improvement without much increase in risks.Objective: To summarize the current state of evidence for the efficacy and safety of combining biologics with phototherapy in the treatment of moderate-to-severe plaque psoriasis.Methods: We conducted an extensive search on Pubmed database for English language literature that evaluated the use of a combination of biologic and phototherapy for the treatment of moderate-to-severe psoriasis through January 2016. The search included the following keywords: psoriasis, etanercept, adalimumab, infliximab, ustekinumab, biologics, phototherapy, and combination therapy.Results: The primary literature included randomized controlled trials, a head-to-head study, open-label controlled and uncontrolled trials, case series, and case reports. Etanercept was used in over half of the reported cases, but other biologic agents used included ustekinumab, adalimumab, and infliximab. The vast majority of phototherapy was narrowband ultraviolet B (NBUVB radiation. Most cases reported enhanced improvement with combination therapy. Serious adverse events throughout the study duration

  8. Estimation of the activity and doses to personnel which intake Iodine 131 by coffee consumption in a cabinet of Nuclear Medicine

    International Nuclear Information System (INIS)

    Ruiz C, M.A.; Alfaro L, M.; Salinas, J.A.; Molina, G.

    2003-01-01

    Soon after an incident in a cabinet of nuclear medicine, its were carried out in the National Institute of Nuclear Research of Mexico (ININ), a series of bio essays measurements by whole-body counting to six people attributed to this cabinet. Of six people, five are classified as Occupational Exposed Personnel (POE), and the other one that works as secretary, according to the General Regulation of Radiological Safety, is classified as public member. Six people that were involved in this incident, the one which presumably it took place among November 15 and 18, 2002 and that it consisted on the effusion of a vial containing an unknown quantity of Iodine-131 to a coffeepot, they ingested coffee in diverse quantities. The Iodine-131 is used in nuclear medicine, so much for the illnesses diagnostic like in the treatment of thyroid cancer and of hyperthyroidism. (Author)

  9. Biologic agents therapy for Saudi children with rheumatic diseases: indications and safety.

    Science.gov (United States)

    Al-Mayouf, Sulaiman M; Alenazi, Abdullatif; AlJasser, Hind

    2016-06-01

    To report the indications and safety of biologic agents in childhood rheumatic diseases at a tertiary hospital. Children with rheumatic diseases treated with biologic agents at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, from January 2001 to December 2011 were included. All patients were reviewed for: demographic characteristics, diagnosis, concomitant treatment and indications of using biologic agents, age at start of therapy and side effects during the treatment period. In all, 134 children (89 female) with various rheumatic diseases were treated with biologic agents. Mean age at starting biologic treatment was 9.3 (4.25-14) years and mean therapy duration was 14.7 (3-88) months. Juvenile idiopathic arthritis (JIA) was the most frequent diagnosis (70.1%) followed by systemic lupus erythematosus (12.7%) and vasculitis (4.5%). All patients received concomitant therapy (corticosteroids and disease-modifying antirheumatic drugs). In total, 273 treatments with biologic agents were used, (95 etanercept, 52 rituximab, 47 adalimumab, 37 infliximab, 23 anakinra, 10 tocilizumab and nine abatacept). Therapy was switched to another agent in 57 (42.5%) patients, mainly because of inefficacy (89.4%) or adverse event (10.6%). A total of 95 (34.8%) adverse events were notified; of these, the most frequent were infusion-related reactions (33.7%) followed by infections (24.2%) and autoantibody positivity (10.6%). One patient developed macrophage activation syndrome. Biologic agents were used in children with a range of rheumatic diseases. Of these, the most frequent was JIA. Off-label use of biologic agents in our cohort is common. These agents seem safe. However, they may associated with various adverse events. Sequential therapy seems well tolerated. However, this should be carefully balanced and considered on an individual basis. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  10. A controllable bacterial lysis system to enhance biological safety of live attenuated Vibrio anguillarum vaccine.

    Science.gov (United States)

    Chu, Teng; Guan, Lingyu; Shang, Pengfei; Wang, Qiyao; Xiao, Jingfan; Liu, Qin; Zhang, Yuanxing

    2015-08-01

    Bacterial strains used as backbone for the generation of vaccine prototypes should exhibit an adequate and stable safety profile. Given the fact that live attenuated vaccines often contain some potential risks in virulence recovery and spread infections, new approaches are greatly needed to improve their biological safety. Here, a critically iron-regulated promoter PviuA was screened from Vibrio anguillarum, which was demonstrated to respond to iron-limitation signal both in vitro and in vivo. By using PviuA as a regulatory switch to control the expression of phage P22 lysis cassette 13-19-15, a novel in vivo inducible bacterial lysis system was established in V. anguillarum. This system was proved to be activated by iron-limitation signals and then effectively lyse V. anguillarum both in vitro and in vivo. Further, this controllable bacterial lysis system, after being transformed into a live attenuated V. anguillarum vaccine strain MVAV6203, was confirmed to significantly improve biological safety of the live attenuated vaccine without impairing its immune protection efficacy. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Static analysis of rectifier cabinet for nuclear power generating stations based on finite element method

    Science.gov (United States)

    Yin, Qiang; Chen, Tian-jin; Li, Wei-yang; Xiong, Ze-cheng; Ma, Rui

    2017-09-01

    In order to obtain the deformation map and equivalent stress distribution of rectifier cabinet for nuclear power generating stations, the quality distribution of structure and electrical are described, the tensile bond strengths of the rings are checked, and the finite element model of cabinet is set up by ANSYS. The transport conditions of the hoisting state and fork loading state are analyzed. The deformation map and equivalent stress distribution are obtained. The attentive problems are put forward. It is a reference for analysis method and the obtained results for the transport of rectifier cabinet for nuclear power generating stations.

  12. Creating a highway information system for safety roadway features.

    Science.gov (United States)

    2015-12-01

    Roadway departures are the leading cause of roadside fatalities. The Kentucky Transportation Cabinet (KYTC) has : undertaken a number of roadside safety measures to reduce roadway departures. Specifically, KYTC has installed : several low-cost, syste...

  13. Development of a user interface style guide for the reactor protection system cabinet operator module

    International Nuclear Information System (INIS)

    Lee, Hyun-Chul; Lee, Dong-Young; Lee, Jung-Woon

    2004-01-01

    The reactor protection system (RPS) plays the roles of generating the reactor trip signal and the engineered safety features (ESF) actuation signal when the monitored plant processes reach the predefined limits. A Korean project group is developing a new digitalized RPS and the Cabinet Operator Module (COM) of the RPS is used for the RPS integrity testing and monitoring by an equipment operator. A flat panel display (FPD) with a touch screen capability is provided as a main user interface for the RPS operation. To support the RPS COM user interface design, actually the FPD screen design, we developed a user interface style guide because the system designer could not properly deal with the many general human factors design guidelines. To develop the user interface style guide, various design guideline gatherings, a walk-though with a video recorder, guideline selection with respect to user interface design elements, determination of the properties of the design elements, discussion with system designers, and a conversion of the properties into the screen design were carried out. This paper describes the process details and the findings in the course of the style guide development. (Author)

  14. The Railway Transport Cabinet of the Kyiv Commercial Institute: educational activities and library

    Directory of Open Access Journals (Sweden)

    Afanasievа Z.

    2014-01-01

    Full Text Available In the article the history of foundation and activities of the Railway Transport Cabinet of the Kyiv Commercial Institute are recreated and an attempt is made to trace the way of its library book fonds which "has been lost" during the institute numerous transformations.The Railway Transport Cabinet was established as a supportive educational subdivision of the Merchandising Museum of the Kyiv Commercial Institute. Its purpose was to gather materials on railway science from the improved models of railway transport to the rich collection of specialized literature in foreign languages. In this regard a library was organized in a cabinet; it consisted of professional books and documents covering the railway science, railroads organization and operation, various manuals, diagrams etc. The novelty of the publication lies in the disclosure of the history of the Kyiv Commercial Institute Railway Transport Cabinet library, which has not yet been an object of a special book science research.

  15. CAPITAL MARKET’S REACTION TOWARDS 2014 WORKING CABINET ANNOUNCEMENT (INDONESIAN CASE STUDY

    Directory of Open Access Journals (Sweden)

    Anindya Ardiansari

    2015-03-01

    Full Text Available The purpose of this study is to examine the market reaction regarding the announcement  of working cabinet following the election of Jokowi as the President of Indonesia. Political events such as presidential election, government change, cabinet announcement, and other events are very influential towards price and trade volume at the stock exchange since the political events are closely related to the state economy stability.  The Sample in this study is stock which was listed as issuers in Indonesia Stock Exchange (IDX which included in LQ45 company group during this research period from 20 October– 3 November 2014. The result shows that there was significant effect towards abnormal return difference before and after the cabinet announcement on the companies listed in LQ 45. The existence of this significant difference means that market reacted with the cabinet announcement event.

  16. Kentucky Transportation Cabinet : annual assessment of customer needs and satisfaction : mail survey report

    Science.gov (United States)

    1997-11-01

    The Kentucky Transportation Cabinet, both through its own quality initiative and a statewide 'Empower Kentucky' campaign, has a commitment to achieve new levels of quality in the development, construction and maintenance of highways. In order to gage...

  17. Biological effects of electromagnetic fields and recently updated safety guidelines for strong static magnetic fields

    International Nuclear Information System (INIS)

    Yamaguchi-Sekino, Sachiko; Sekino, Masaki; Ueno, Shoogo

    2011-01-01

    Humans are exposed daily to artificial and naturally occurring magnetic fields that originate from many different sources. We review recent studies that examine the biological effects of and medical applications involving electromagnetic fields, review the properties of static and pulsed electromagnetic fields that affect biological systems, describe the use of a pulsed electromagnetic field in combination with an anticancer agent as an example of a medical application that incorporates an electromagnetic field, and discuss the recently updated safety guidelines for static electromagnetic fields. The most notable modifications to the 2009 International Commission on Non-Ionizing Radiation Protection guidelines are the increased exposure limits, especially for those who work with or near electromagnetic fields (occupational exposure limits). The recommended increases in exposure were determined using recent scientific evidence obtained from animal and human studies. Several studies since the 1994 publication of the guidelines have examined the effects on humans after exposure to high static electromagnetic fields (up to 9.4 tesla), but additional research is needed to ascertain further the safety of strong electromagnetic fields. (author)

  18. Biological effects of electromagnetic fields and recently updated safety guidelines for strong static magnetic fields.

    Science.gov (United States)

    Yamaguchi-Sekino, Sachiko; Sekino, Masaki; Ueno, Shoogo

    2011-01-01

    Humans are exposed daily to artificial and naturally occurring magnetic fields that originate from many different sources. We review recent studies that examine the biological effects of and medical applications involving electromagnetic fields, review the properties of static and pulsed electromagnetic fields that affect biological systems, describe the use of a pulsed electromagnetic field in combination with an anticancer agent as an example of a medical application that incorporates an electromagnetic field, and discuss the recently updated safety guidelines for static electromagnetic fields. The most notable modifications to the 2009 International Commission on Non-Ionizing Radiation Protection guidelines are the increased exposure limits, especially for those who work with or near electromagnetic fields (occupational exposure limits). The recommended increases in exposure were determined using recent scientific evidence obtained from animal and human studies. Several studies since the 1994 publication of the guidelines have examined the effects on humans after exposure to high static electromagnetic fields (up to 9.4 tesla), but additional research is needed to ascertain further the safety of strong electromagnetic fields.

  19. Taking Stock: Marie Nimier’s Textual Cabinet of Curiosities

    Directory of Open Access Journals (Sweden)

    Adrienne Angelo

    2014-01-01

    Full Text Available In many life-writing projects, the seemingly innocuous description of heteroclite objects and how those objects are stored and recalled in fact plays an important role in demonstrating their importance to the process of memory work. At once the lingering traces of one’s past and also an aggregation of stories evoked by an examination of them, these curios focus attention on the relationship between the individual and the storage of memories. This article will focus on certain collectibles, collections and collectors that appear throughout the fictional, autobiographical and autofictional world that Marie Nimier has scripted to date. This textual cabinet of curiosities and the act of collecting more generally serve as a trope to connect memory with materiality, despite the numerous narrative voices that Nimier assumes—voices that move from a first-person “Marie Nimier” to an unnamed, although clearly identifiable first-person and even float between genders. Despite this nominal and narrational fluidity, objects function to guarantee recognition, both for the reader, and, especially, for the author herself. What is at stake in this intertextual assemblage of objects is not only the roles that they play in allowing the narrator to revisit past traumas and loss, but also in connecting the author’s presence to other, more fictionalized voices that above all signify the primacy of life-writing in her corpus.

  20. Efficacy and Safety Data of Subsequent Entry Biologics Pertinent to Nephrology Practice: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Judith Genevieve Marin

    2014-12-01

    Full Text Available Background: Subsequent entry biologics (SEBs may soon be a reality in Canadian nephrology practice. Understanding the worldwide experience with these agents will be valuable to Canadian clinicians. Objectives: To compare the efficacy and safety data between SEBs used in nephrology practice and their reference biologic. Design: Systematic review. Sources of information: Ovid MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Database of Abstracts of Review of Effects, Cochrane Central Register of Controlled Trials. Patients: Adult patients with chronic kidney disease (CKD. Methods: Our systematic review follows the process outlined by Cochrane Reviews. For efficacy data, all randomized controlled trials (RCTs, quasi-RCTs and observational trials in nephrology practice were included. For safety data, case series, case reports, review articles in nephrology practice and pharmacovigilance programs were included as well. Results: Only epoetin SEBs trials were published in the literature. Ten studies involving three different epoetin SEBs (epoetin zeta, HX575 and epoetin theta were included. The mean epoetin dose used did not differ significantly between the SEBs and the reference product. For epoetin zeta and epoetin theta, the mean hemoglobin levels achieved in the studies were similar between the SEBs and the reference epoetin. The HX 575 studies reported a mean absolute change in hemoglobin within the predefined equivalence margin, when compared with the reference biologic. In terms of safety data, 2 cases of pure-red-cell aplasia were linked to the subcutaneous administration of HX 575. Otherwise, the rate of adverse drug reactions was similar when epoetin SEBs were compared with the reference biologic. Limitations: Our analysis is limited by the paucity of information available on SEB use in nephrology with the exception of epoetin SEBs. Methodological flaw was found in one of the epoetin zeta studies which accounted for 45% of pooled

  1. A new method for evaluating biological safety of environmental water with algae, daphnia and fish toxicity ranks

    Energy Technology Data Exchange (ETDEWEB)

    Wei Dongbin [Graduate School of Environment and Information Sciences, Yokohama National University, 79-7 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 (Japan)]. E-mail: wei-db@163.com; Kisuno, Akira [Graduate School of Environment and Information Sciences, Yokohama National University, 79-7 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 (Japan); Kameya, Takashi [Graduate School of Environment and Information Sciences, Yokohama National University, 79-7 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 (Japan); Urano, Kohei [Graduate School of Environment and Information Sciences, Yokohama National University, 79-7 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 (Japan)

    2006-12-01

    In this study, an innovative approach to evaluate biological safety of environmental water with toxicity ranks was proposed. Widely used species, algae (Selenustrum capricornutum), daphnia (Daphnia magna) and fish (Oryzias latipes larvae) belonging to three trophic levels in aquatic ecosystem, were selected and combined as a test set to measure the bio-toxicity of water sample. Maximum exposure concentrations for algae, daphnia and fish test were respectively designed as 10-, 50- and 50-fold of river water based on a simplification of conventional toxicity extrapolation method EU Directive EEC/93/67. A novel assessment index 'safety score' of 1, 2, 3 and 4 with 1 being the safest was established for normalizing the toxicity effects. Safety score was determined according to the highest exposure concentration where adverse ecotoxicological effects could not be observed, and a triangle figure was designed to visually describe the safety scores of three toxicity tests. Finally, in order to conveniently evaluate the biological safety of environmental water, an integrated assessment index 'bio-safety rank' (BSR) was established and determined according to the safety scores of the three tests, and with the index BSR, water sample could be ranked as A, B, C or D with A being the safest. It was shown that the proposed new method was effective for screening and evaluating the biological safety of river water in case studies.

  2. Safety of resuming biologic DMARDs in patients who develop tuberculosis after anti-TNF treatment.

    Science.gov (United States)

    Cho, Soo-Kyung; Kim, Dam; Won, Soyoung; Han, Minkyung; Lee, Jiyoung; Jang, Eun Jin; Kim, Tae-Hyung; Bae, Sang-Cheol; Sung, Yoon-Kyoung

    2017-08-01

    To estimate the incidence of tuberculosis (TB) in rheumatoid arthritis (RA) patients treated with tumor necrotizing factor inhibitor (TNFI) and evaluate the safety of resuming biologic disease-modifying anti-rheumatic drugs (DMARDs) in patients who developed TB after anti-TNF treatment. We conducted an inception cohort study of RA patients in the Korean Healthcare Claims Database who started TNFI as the first biologic DMARD between January 2009 and December 2013. The incidence rate (IR) of TB was estimated among total TNFI starters and a nested case-control analysis was performed to compare the characteristics of patients who developed TB and those did not. Patients diagnosed with relapsed TB after resuming biologic DMARDs were identified and their features were described. We included 4638 RA patients who started TNFI, contributing 8542 PYs of follow-up. The IR of TB in TNFI users was 1.10 (CI: 0.86-1.34) per 100 PYs. After the initial 6 months, the IR was highest at 1.56 (CI: 1.02-2.10) and decreased gradually over time. Among the 81 patients who developed TB, 30 patients (37.0%) resumed biologic DMARDs with a mean interval of 3.3 months after TB development. Two cases of TB were detected among 30 patients with an observational period of 45.7 PY. The IR of TB in RA patients who started TNFI was 1.10 per 100 PYs. This rate was highest during the first 6 months. Resumption of biologic DMARDs requires careful monitoring for TB relapse. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Implementation and optimization of automated dispensing cabinet technology.

    Science.gov (United States)

    McCarthy, Bryan C; Ferker, Michael

    2016-10-01

    A multifaceted automated dispensing cabinet (ADC) optimization initiative at a large hospital is described. The ADC optimization project, which was launched approximately six weeks after activation of ADCs in 30 patient care unit medication rooms of a newly established adult hospital, included (1) adjustment of par inventory levels (desired on-hand quantities of medications) and par reorder quantities to reduce the risk of ADC supply exhaustion and improve restocking efficiency, (2) expansion of ADC "common stock" (medications assigned to ADC inventories) to increase medication availability at the point of care, and (3) removal of some infrequently prescribed medications from ADCs to reduce the likelihood of product expiration. The purpose of the project was to address organizational concerns regarding widespread ADC medication stockouts, growing reliance on cart-fill medication delivery systems, and suboptimal medication order turnaround times. Leveraging of the ADC technology platform's reporting functionalities for enhanced inventory control yielded a number of benefits, including cost savings resulting from reduced pharmacy technician labor requirements (estimated at $2,728 annually), a substantial reduction in the overall weekly stockout percentage (from 3.2% before optimization to 0.5% eight months after optimization), an improvement in the average medication turnaround time, and estimated cost avoidance of $19,660 attributed to the reduced potential for product expiration. Efforts to optimize ADCs through par level optimization, expansion of common stock, and removal of infrequently used medications reduced pharmacy technician labor, decreased stockout percentages, generated opportunities for cost avoidance, and improved medication turnaround times. Copyright © 2016 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  4. Research on conceptual design of simplified nuclear safety instrument and control system

    International Nuclear Information System (INIS)

    Huang Jie

    2015-01-01

    The Nuclear safety instrument and control system is directly related to the safety of the reactor. So redundant and diversity design is used to ensure the system's security and reliability. This make the traditional safety system large, more cabinets and wiring complexity. To solve these problem, we can adopt new technology to make the design more simple. The simplify conceptual design can make the system less cabinets, less wiring, but high security, strong reliability. (author)

  5. Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary

    Science.gov (United States)

    Wang, J; Johnson, T; Sahin, L; Tassinari, MS; Anderson, PO; Baker, TE; Bucci-Rechtweg, C; Burckart, GJ; Chambers, CD; Hale, TW; Johnson-Lyles, D; Nelson, RM; Nguyen, C; Pica-Branco, D; Ren, Z; Sachs, H; Sauberan, J; Zajicek, A; Ito, S; Yao, LP

    2017-01-01

    This report serves as a summary of a 2-day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum to discuss the collection of data to inform the potential risks to breastfed infants with maternal use of medications during lactation. Discussions included the review of current approaches to collect data on medications used during lactation, and the considerations for future approaches to design and guide clinical lactation studies. This workshop is part of continuing efforts to raise the awareness of the public for women who choose to breastfeed their infants. PMID:28510297

  6. Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

    Directory of Open Access Journals (Sweden)

    P. Annécie Benatrehina

    2018-04-01

    Full Text Available In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases. Laboratory studies on açaí have shown both its antioxidant and anti-inflammatory activities in vitro, and more importantly, its neuroprotective properties in animals. Anthraquinones and iridoid glucosides isolated from noni fruit induce the phase II enzyme quinone reductase (QR, and noni fruit juice exhibited antitumor and antidiabetic activities in certain animal models. Antitumorigenic effects of mangosteen in animal xenograft models of human cancers have been attributed to its xanthone content, and pure α-mangostin was shown to display antineoplastic activity in mice despite a reported low oral bioavailability. Work on the less extensively investigated black chokeberry and maqui berry has focused on recent isolation studies and has resulted in the identification of bioactive secondary metabolites with QR-inducing and hydroxyl-radical scavenging properties. On the basis of the safety studies and toxicity case reports described herein, these fruits may be generally considered as safe. However, cases of adulteration found in a commercialized açaí product and some conflicting results from mangosteen safety studies warrant further investigation on the safety of these marketed botanical dietary supplements. Keywords: Açaí, Noni, Mangosteen, Black chokeberry, Maqui berry

  7. Safety

    International Nuclear Information System (INIS)

    1998-01-01

    A brief account of activities carried out by the Nuclear power plants Jaslovske Bohunice in 1997 is presented. These activities are reported under the headings: (1) Nuclear safety; (2) Industrial and health safety; (3) Radiation safety; and Fire protection

  8. Single Party Cabinets and Presidential Democracies: insights from the Argentinean case

    Directory of Open Access Journals (Sweden)

    Marcelo CAMERLO

    2013-07-01

    Full Text Available The study of presidential cabinets has mainly focused on coalitional formations, distinguishing individual ministers in terms of their party affiliation particularly at cabinet instauration and termination. This article moves the focus to single-party cabinets to study minister appointment in situations where the legislative support is less relevant. A model of analysis that observes extra-partisan affiliations, individual technical skills and personal liaison with the president is proposed and exploratory applied to the Argentinean case. The results suggest that well positioned presidents tend to apply closer strategies of portfolio distribution, with levels of institutionalization that depends on the president’s party organization and the president’s style of leadership.

  9. Human Factors Support in the Design and Evaluation of the Reactor Protection System Cabinet Operator Module

    International Nuclear Information System (INIS)

    Lee, Hyun Chul; Lee, Jung Woon

    2005-01-01

    A Korean project group, KNICS, is developing a new digitalized reactor protection system (RPS) and the developed system will be packaged into a cabinet with several racks. The cabinet of the RPS is used for the RPS function testing and monitoring by maintenance operators and is equipped with a flat panel display (FPD) with a touch screen capability as a main user interface for the RPS operation. This paper describes the human factors activities involved in the development process of the RPS: conceptual design, design guidance, and evaluation. The activities include a functional requirements analysis and task analysis, user interface style guide for the RPS cabinet operator module (COM), and a human factors evaluation through an experiment and questionnaires

  10. Population-based cohort study on comparative effectiveness and safety of biologics in inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Di Domenicantonio R

    2018-02-01

    Full Text Available Riccardo Di Domenicantonio,1 Francesco Trotta,1 Silvia Cascini,1 Nera Agabiti,1 Anna Kohn,2 Antonio Gasbarrini,3 Marina Davoli,1 Antonio Addis1 1Department of Epidemiology, Lazio Regional Health Service, Rome, Italy; 2IBD Unit, AO San Camillo Forlanini, Rome, Italy; 3Department of Internal Medicine, Agostino Gemelli University Hospital, Catholic University of Sacred Heart, Rome, Italy Background: The comparison of effectiveness and safety of anti-tumor necrosis factor-alpha agents for the treatment of inflammatory bowel disease (IBD is relevant for clinical practice and stakeholders. Objective: The objective of this study was to compare the risk of abdominal surgery, steroid utilization, and hospitalization for infection in Crohn’s disease (CD or ulcerative colitis (UC patients newly treated with infliximab (IFX or adalimumab (ADA. Methods: A retrospective population-based cohort study was performed using health information systems data from Lazio region, Italy. Patients with CD or UC diagnosis were enrolled at first prescription of IFX or ADA during 2008–2014 (index date. Only new drug users were followed for 2 years from the index date. IFX versus ADA adjusted hazard ratios were calculated applying “intention-to-treat” approach, controlling for several characteristics and stratifying the analysis on steroid use according to previous drug utilization. Sensitivity analyses were performed according to “as-treated” approach, adjusting for propensity score, censoring at switching or discontinuation, and evaluating different lengths of follow-up periods. Results: We enrolled 1,432 IBD patients (42% and 83% exposed to IFX for CD and UC, respectively. In both diseases, treatment effects did not differ in any outcome considered, and sensitivity analyses confirmed the results from the main analysis. Conclusion: In our population-based cohort study, effectiveness and safety data in new users of ADA or IFX with CD or UC were comparable for the

  11. Prediction of Dangerous Time in Case Hydrocarbon Refrigerant Leaks into Household Refrigerator Cabinet

    Science.gov (United States)

    Meguro, Takatoshi; Kaji, Nobufuji; Miyake, Kunihiro

    Hydrocarbon refrigerators are now on sale in European countries. However, hydrocarbons are flammable. A common claim is that concentration of hydrocarbon in the refrigerator could exceed the lower explosive limit by a sudden leak and then a spark ignites a flame causing overpressure. There is the need of the studies on potential risks originated from the use of flammable refrigerants. Thus, the flow rate of the fresh air into the refrigerator cabinet has been defined experimentally, and the spatial average concentration in the refrigerator cabinet has been analyzed theoretically to predict the dangerous time in excess of the lower explosive limit.

  12. A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

    Directory of Open Access Journals (Sweden)

    Jie Mao

    2017-03-01

    Full Text Available Abstract Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed that the main adverse events were allergic reaction and pain at the administration site. To decrease the toxicity, we prepared melittin nano-liposomes by encapsulating melittin with poloxamer 188 and explored the inhibitory activities on liver cancer together with biological safety. Here, we showed that melittin nano-liposomes significantly inhibited the survival of hepatocellular carcinoma (HCC cells in vitro and prominently suppressed the growth of subcutaneous and orthotopic HCC transplantation tumors in vivo. It was important that it induced less inflammation and allergy in mice compared with melittin. Overall, melittin nano-liposomes would have a better application in HCC therapy due to its significant anti-tumor activity and better biological safety.

  13. A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety.

    Science.gov (United States)

    Mao, Jie; Liu, Shujun; Ai, Min; Wang, Zhuo; Wang, Duowei; Li, Xianjing; Hu, Kaiyong; Gao, Xinghua; Yang, Yong

    2017-03-20

    Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed that the main adverse events were allergic reaction and pain at the administration site. To decrease the toxicity, we prepared melittin nano-liposomes by encapsulating melittin with poloxamer 188 and explored the inhibitory activities on liver cancer together with biological safety. Here, we showed that melittin nano-liposomes significantly inhibited the survival of hepatocellular carcinoma (HCC) cells in vitro and prominently suppressed the growth of subcutaneous and orthotopic HCC transplantation tumors in vivo. It was important that it induced less inflammation and allergy in mice compared with melittin. Overall, melittin nano-liposomes would have a better application in HCC therapy due to its significant anti-tumor activity and better biological safety.

  14. Chemical Compositional, Biological, and Safety Studies of a Novel Maple Syrup Derived Extract for Nutraceutical Applications

    Science.gov (United States)

    2015-01-01

    Maple syrup has nutraceutical potential given the macronutrients (carbohydrates, primarily sucrose), micronutrients (minerals and vitamins), and phytochemicals (primarily phenolics) found in this natural sweetener. We conducted compositional (ash, fiber, carbohydrates, minerals, amino acids, organic acids, vitamins, phytochemicals), in vitro biological, and in vivo safety (animal toxicity) studies on maple syrup extracts (MSX-1 and MSX-2) derived from two declassified maple syrup samples. Along with macronutrient and micronutrient quantification, thirty-three phytochemicals were identified (by HPLC-DAD), and nine phytochemicals, including two new compounds, were isolated and identified (by NMR) from MSX. At doses of up to 1000 mg/kg/day, MSX was well tolerated with no signs of overt toxicity in rats. MSX showed antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay) and anti-inflammatory (in RAW 264.7 macrophages) effects and inhibited glucose consumption (by HepG2 cells) in vitro. Thus, MSX should be further investigated for potential nutraceutical applications given its similarity in chemical composition to pure maple syrup. PMID:24983789

  15. Ontology-supported research on vaccine efficacy, safety and integrative biological networks.

    Science.gov (United States)

    He, Yongqun

    2014-07-01

    While vaccine efficacy and safety research has dramatically progressed with the methods of in silico prediction and data mining, many challenges still exist. A formal ontology is a human- and computer-interpretable set of terms and relations that represent entities in a specific domain and how these terms relate to each other. Several community-based ontologies (including Vaccine Ontology, Ontology of Adverse Events and Ontology of Vaccine Adverse Events) have been developed to support vaccine and adverse event representation, classification, data integration, literature mining of host-vaccine interaction networks, and analysis of vaccine adverse events. The author further proposes minimal vaccine information standards and their ontology representations, ontology-based linked open vaccine data and meta-analysis, an integrative One Network ('OneNet') Theory of Life, and ontology-based approaches to study and apply the OneNet theory. In the Big Data era, these proposed strategies provide a novel framework for advanced data integration and analysis of fundamental biological networks including vaccine immune mechanisms.

  16. 75 FR 59935 - Investigational New Drug Safety Reporting Requirements for Human Drug and Biological Products and...

    Science.gov (United States)

    2010-09-29

    .... SUMMARY: The Food and Drug Administration (FDA) is amending its regulations governing safety reporting... safety reporting for human drug products: Janet Norden, Center for Drug Evaluation and Research, Food and.... Costs of the Regulation (to Prepare and Submit Safety Reports) C. Benefits of the Regulation D. Final...

  17. Space Biology and Medicine. Volume 4; Health, Performance, and Safety of Space Crews

    Science.gov (United States)

    Dietlein, Lawrence F. (Editor); Pestov, Igor D. (Editor)

    2004-01-01

    Volume IV is devoted to examining the medical and associated organizational measures used to maintain the health of space crews and to support their performance before, during, and after space flight. These measures, collectively known as the medical flight support system, are important contributors to the safety and success of space flight. The contributions of space hardware and the spacecraft environment to flight safety and mission success are covered in previous volumes of the Space Biology and Medicine series. In Volume IV, we address means of improving the reliability of people who are required to function in the unfamiliar environment of space flight as well as the importance of those who support the crew. Please note that the extensive collaboration between Russian and American teams for this volume of work resulted in a timeframe of publication longer than originally anticipated. Therefore, new research or insights may have emerged since the authors composed their chapters and references. This volume includes a list of authors' names and addresses should readers seek specifics on new information. At least three groups of factors act to perturb human physiological homeostasis during space flight. All have significant influence on health, psychological, and emotional status, tolerance, and work capacity. The first and most important of these factors is weightlessness, the most specific and radical change in the ambient environment; it causes a variety of functional and structural changes in human physiology. The second group of factors precludes the constraints associated with living in the sealed, confined environment of spacecraft. Although these factors are not unique to space flight, the limitations they entail in terms of an uncomfortable environment can diminish the well-being and performance of crewmembers in space. The third group of factors includes the occupational and social factors associated with the difficult, critical nature of the

  18. A cabinet for the handling or treatment of materials therein in a protected atmosphere

    International Nuclear Information System (INIS)

    Landy, J.J.

    1978-01-01

    A cabinet is described in which the atmosphere is arranged to move in a recirculatory filtered closed system. It is stated to be suitable for the handling of materials in a protected atmosphere, for example the handling of biohazardous materials, radioactive materials, etc. Full constructional details are given. (U.K.)

  19. 78 FR 76710 - Notice of Buy America Waiver for a Video Ready Access Device Cabinet

    Science.gov (United States)

    2013-12-18

    ... cabinet needed for an AT&T utility relocation associated with the Charlotte Area Transit System's (CATS... Transit System's (CATS or City of Charlotte) LYNX Blue Line Extension (BLE) project, which is an FTA... manufactured goods used in the project are produced in the United States.'' 49 U.S.C. 5323(j)(1). A...

  20. From vanitas to veneration: the embellishments in the anatomical cabinet of Frederik Ruysch

    NARCIS (Netherlands)

    van de Roemer, G.M.

    2010-01-01

    The elaborate way in which the Dutch anatomist Frederik Ruysch (1638-1731) decorated and presented his anatomical cabinet has raised questions as to whether we should view him as a scientist or rather as an artist. The concept of the collection as ‘baroque monument’ or as merely ‘bizarre’ fails to

  1. Sources of product information used by consumers when purchasing kitchen cabinets.

    Science.gov (United States)

    Geoffrey H. Donovan; David L. Nicholls; Joseph. Roos

    2004-01-01

    Survey data from home shows in Seattle, Washington and Anchorage, Alaska were used to determine the sources of product information used by consumers when buying kitchen cabinets. Results show that in-store sales staff are the most common source of product information, and that consumers' favorite wood species, age, and gender can influence the source of product...

  2. DEMONSTRATION OF A NO-VOC/NO-HAP WOOD KITCHEN CABINET COATING SYSTEM

    Science.gov (United States)

    The report gives results of the development and demonstration of a no-VOC (volatile organic compound)/no-HAP (hazardous air pollutant) wood furniture coating system at two cabinet manufacturing plants: one in Portland, OR, and the other in Redwood City, CA. Technology transfer ef...

  3. Spinal cordd biological safety comparison of intensity modulated radiotherapy and conventional radiation therapy

    International Nuclear Information System (INIS)

    Xilinbaoleri; Xu Wanlong; Chen Gang; Liu Hao; Wang Ruozheng; Bai Jingping

    2010-01-01

    Objective: To compare the spine intensity modulated radiation therapy (IMRT) and the conventional radiation therapy on the beagle spinal cord neurons, in order to prove the biological safety of IMRT of the spinal cord. Methods: Twelve selected purebred beagles were randomly divided into 2 groups. A beagle clinical model of tumor was mimiced in the ninth and tenth thoracic vertebrae. Then the beagles were irradiated by 2 different models of intensity modulated radiotherapy and conventional radiation therapy, with the total irradiation doses of 50 and 70 Gy. The samples of spinal cord were taken out from the same position of the nine and tenth thoracic vertebrae at the third month after radiation.All the samples were observed by the electron microscope, and the Fas and HSP70 expression in spinal cord neurons were evaluated by immunohistochemistry method. Terminal deoxynucleatidyl transferase mediated dUTP nick and labeling (TUNEL) technique was used to examine the apoptotic cells in the spinal cord. Results: The neurons in the spinal cord of IMRT group were mainly reversible injury, and those in the conventional radiation therapy were mainly apoptosis. Compared with the conventional radiation therapy group [50 Gy group, (7.3 ± 1.1)%; 70 Gy group, (11.3 ± 1.4)%], the apoptosis rate of the spinal cord neurons of the intensity modulated radiotherapy group [50 Gy group, (1.2 ± 0.7)%; 70 Gy group (2.5 ± 0.8)%] was much lower[(50 Gy group, t=0.022, P<0.05; 70 Gy group, t=0.017, P<0.05)]. The expression levels of Fas in the IMPT group (50 Gy group, 4.6 ± 0.8; 70 Gy group, 7.4 ± 1.1) were also much lowerthan those in the other group (50 Gy group, 15.1 ± 6.4; 70 Gy group, 19.3 ± 7.6. 50 Gy group, t=0.231, P<0.05; 70 Gy group, t=0.457, P<0.05), while the expression levels of HSP70 in the IMPT group (50 Gy group, 9.1 ± 0.8; 70 Gy group, 7.3 ± 1.4)were much higher than those in the conventional radiation therapy group (50 Gy group, 2.1 ± 0.9; 70 Gy group, 1.7 ± 0

  4. Energy and exergy analysis of an indirect solar cabinet dryer based on mathematical modeling results

    International Nuclear Information System (INIS)

    Sami, Samaneh; Etesami, Nasrin; Rahimi, Amir

    2011-01-01

    In the present study, using a previously developed dynamic mathematical model for performance analysis of an indirect cabinet solar dryer , a microscopic energy and exergy analysis for an indirect solar cabinet dryer is carried out. To this end, appropriate energy and exergy models are developed and using the predicted values for temperature and enthalpy of gas stream and the temperature, enthalpy and moisture content of the drying solid, the energy and exergy efficiencies are estimated. The validity of the model for predicting variations in gas and solid characteristics along the time and the length of the solar collector and/or dryer length was examined against some existing experimental data. The results show that in spite of high energy efficiency, the indirect solar cabinet dryer has relatively low exergy efficiency. Results show that the maximum exergy losses are in midday. Also the minimums of total exergy efficiency are 32.3% and 47.2% on the first and second days, respectively. Furthermore, the effect of some operating parameters, including length of the collector, its surface, and air flow rate was investigated on the exergy destruction and efficiency. -- Highlights: → In the literature, there are few studies on the energy and exergy analysis of solar cabinet dryers. → In the present study a microscopic energy and exergy analysis for an indirect solar cabinet dryer is carried out. → Effect of operating parameters, including collector length, and air flow rate was investigated on the exergy destruction and efficiency. → For collector section, the maximum values for outlet air temperature, outlet exergy and energy are 69 o C, 2.5 kW and 1.12 kW, respectively. → Increasing the air flow rate decreases the exergy efficiency of solar collector.

  5. Frost formation and defrost control parameters for open multideck refrigerated food display cabinets

    Energy Technology Data Exchange (ETDEWEB)

    Tassou, S.A.; Datta, D. [Brunel Univ., Dept. of Mechanical Engineering, Uxbridge (United Kingdom); Marriott, D. [Safeway Stores plc, Hayes (United Kingdom)

    2001-04-03

    In order to achieve the required air and product temperatures in refrigerated food display cabinets, the evaporator coils, which are normally located in the base of the cabinets, operate at temperatures below the freezing point of water. The air which is circulated over the evaporator coil is cooled below its dew point and water vapour present in the air condenses and eventually freezes on the coil surface. With continuous operation of the coil, frost will accumulate on the coil surface leading to a decrease both in the air flowrate and in the overall heat transfer coefficient. In order to maintain satisfactory performance, evaporator coils are defrosted periodically. Although different defrost control strategies can be employed, for simplicity and cost considerations, defrosting in supermarket refrigeration systems is usually controlled by a pre-set time cycle. It is widely acknowledge, however, that time-based defrost may cause a number of unnecessary defrost cycles and this reduces the energy efficiency of the refrigeration systems as well as the accuracy of temperature control of the cabinets. Implementing defrost only when it is needed or on 'demand' should reduce the number of defrost cycles and lead to savings in energy and improved product quality. This paper reports on field and experimental investigations on the processes of frosting and defrosting of medium-temperature display cabinet evaporator coils. The results show that for medium-temperature refrigeration applications where the environment temperature is kept reasonably constant, the store humidity is the primary parameter influencing the rate of frost formation. Using relative humidity as a control parameter the defrost frequency can be reduced considerably without affecting cabinet performance and product integrity. Alongside the effect of relative humidity, the paper also considers the effects of other performance parameters on the processes of frosting and defrosting such as cooling

  6. SAFETY

    CERN Document Server

    Niels Dupont

    2013-01-01

    CERN Safety rules and Radiation Protection at CMS The CERN Safety rules are defined by the Occupational Health & Safety and Environmental Protection Unit (HSE Unit), CERN’s institutional authority and central Safety organ attached to the Director General. In particular the Radiation Protection group (DGS-RP1) ensures that personnel on the CERN sites and the public are protected from potentially harmful effects of ionising radiation linked to CERN activities. The RP Group fulfils its mandate in collaboration with the CERN departments owning or operating sources of ionising radiation and having the responsibility for Radiation Safety of these sources. The specific responsibilities concerning "Radiation Safety" and "Radiation Protection" are delegated as follows: Radiation Safety is the responsibility of every CERN Department owning radiation sources or using radiation sources put at its disposition. These Departments are in charge of implementing the requi...

  7. [The Polish Task Force position statement on safety of biologic treatment with monoclonal antibodies and soluble receptors].

    Science.gov (United States)

    Jahnz-Rozyk, Karina; Wiesik-Szewczyk, Ewa

    2014-07-01

    The introduction of biologic therapies for treatment in many fields of medicine such as rheumatology oncology, dermatology, hematology and allergology, became one of the most important achievements of the modem medicine. The first biological therapeutics have already reached patent expiration date and corresponding biosimilars were approved by EMA (European Medicine Agency) and FDA (Food and Drug Administration). Many more biosimilar products are currently under review for marketing authorization around the world. The approval of products similar, but not identical to already known innovative biologics, due to complexity of structure and manufacturing technology, stirs a lot of discussions regarding safety concerns related to differences in posttranslational processing and in immunogenicity between reference and biosimilar products, and relevance of these differences to the clinical practice. Critical issues involve extrapolation to different clinical indication, automatic substitution and switching. Despite EMA recommendation and advocacy for biosimilars, it is beyond this regulatory authority to establish definitive regulation for each EU member, which it is expected to be country related. The aim of the study was an attempt to define the stance regarding particular aspects of biological treatment conducted in Poland is undertaken. The Task Force of 13 experts involved in various aspects of biologic therapies in Poland was established. A modified Delphi voting was performed to achieve consensus regarding the most important aspects of biologic treatment in Poland, with particular concern of biosimilars. Ten final statements were discussed and voted upon. The statements cover general aspects of biosimilars including expected cost-benefit ratios, extrapolation of clinical indications, interchange switching, patient information and requirement of patient consent. The state of post marketing pharmacovigilance of biologics (innovative ones as well as biosimilars) was

  8. Home medication cabinets and self-medication: a source of potential health threats?

    Science.gov (United States)

    De Bolle, Leen; Mehuys, Els; Adriaens, Els; Remon, Jean-Paul; Van Bortel, Luc; Christiaens, Thierry

    2008-04-01

    Data regarding the contents of home medication cabinets (HMCs), the management of leftover medications, and the inclination of patients toward self-initiated treatment using nonprescription drugs are scarce. To evaluate the nature and safety of medication storage and intended self-medication in a general population. A cross-sectional study was conducted in 72 Belgian community pharmacies. Pharmacy customers (N = 288, aged 18-80 y) were visited in their homes by pharmacy students. The HMCs were inventoried and the participants were interviewed. A mean of 31 +/- 17 (range 6-136) drug packages were identified per household; in one-third of the cases, the packages were not stored safely. Prescription drugs accounted for 34% of the total. The most frequently encountered categories of registered medicines were nonopioid analgesics (7.2%), nonsteroidal antiinflammatory drugs (NSAIDs) (6.9%), nasal decongestants (3.5%) and antinausea agents (3.2%). Despite their high prevalence, NSAIDs and non-opioid analgesics did not predominate among the most frequently used drugs, whereas food supplements were used daily in 23.3% of households. Twenty-one percent of the drugs were expired, 9% were not stored in the original container, and the package insert was missing for 18%. Self-initiated treatment was considered for 56% of all drugs (over-the-counter drugs, 74%; prescription drugs, 21%). Indication, dosage, or treatment duration was misjudged by only 5.2% of the participants, but consulting the package insert was allowed. The tendency toward self-treatment decreased with age and with increasing number of medications taken daily (p = 0.002). We found large amounts of drugs per household, with a high prevalence of analgesics and NSAIDs. Self-medication, although generally acceptable in terms of indication and dosage, was commonly practiced, also with prescription drugs. Taking into account that younger people showed a significantly higher intention of self-medication, a sustained

  9. Safety

    International Nuclear Information System (INIS)

    2001-01-01

    This annual report of the Senior Inspector for the Nuclear Safety, analyses the nuclear safety at EDF for the year 1999 and proposes twelve subjects of consideration to progress. Five technical documents are also provided and discussed concerning the nuclear power plants maintenance and safety (thermal fatigue, vibration fatigue, assisted control and instrumentation of the N4 bearing, 1300 MW reactors containment and time of life of power plants). (A.L.B.)

  10. Safety

    CERN Multimedia

    2003-01-01

    Please note that the safety codes A9, A10 AND A11 (ex annexes of SAPOCO/42) entitled respectively "Safety responsibilities in the divisions" "The safety policy committee (SAPOCO) and safety officers' committees" and "Administrative procedure following a serious accident or incident" are available on the web at the following URLs: Code A9: http://edms.cern.ch/document/337016/LAST_RELEASED Code A10: http://edms.cern.ch/document/337019/LAST_RELEASED Code A11: http://edms.cern.ch/document/337026/LAST_RELEASED Paper copies can also be obtained from the TIS divisional secretariat, e-mail: tis.secretariat@cern.ch. TIS Secretariat

  11. IINFLUENCE OF FREEZING AND PROLONGED STORAGE OF EXPRESSED BREAST MILK ON ITS NUTRITIVE, BIOLOGICAL VALUES AND MICROBIOLOGICAL SAFETY

    Directory of Open Access Journals (Sweden)

    O. L. Lukoyanova

    2011-01-01

    Full Text Available Evaluation of prolonged storage of breast milk safety for nutrition of newborns remains actual problem of modern nutritiology. Objectives: to evaluate an influence of freezing and prolonged storage of expressed breast milk on its nutritive, biological values and microbiological safety. Methods: samples of expressed breast milk (native samples and after 1 and 3 months of storage in containers Philips AVENT in t -18°С were analyzed; levels of secretory IgA, lysozyme, transforming growth factor (TGF β1, potassium, calcium, magnesium, pH, buffer capacity and bacterial cells were detected. Results: there is no statistically significant influence of low temperature and prolonged storage of expressed breast milk on levels of secretory IgA, lysozyme, TGF β1 and bacterial cells. Potassium and calcium levels significantly decreased (on about 10% and 20% accordingly, pH increased, and buffer capacity of milk lowered after freezing during 3 months. Conclusion: children’s feeding with native and expressed breast milk defrosted after 3 months of storage is equal in nutritive and biological values and microbiological safety.

  12. Vibroacoustic Analysis of a Refrigerator Freezer Cabinet Coupled with an Air Duct

    OpenAIRE

    Onur Çelikkan; Haluk Erol

    2017-01-01

    In this study, the vibration and acoustic interactions between the structure and the cavity inside the freezer cabinet were investigated. Thus, a set of numerical and experimental analyses were performed. In the numerical analysis, the acoustic characteristics of the freezer cavity were solved, and the mixed finite element method was then implemented to analyse the coupled behaviour of the cavity with the air duct using the Acoustic Fluid-Structure Interaction (AFSI) technique. In the experim...

  13. The activity of the Cabinet of Ukrainian Art History of the All-Ukrainian Academy of Sciences

    Directory of Open Access Journals (Sweden)

    M. I. Sichka

    2016-05-01

    As a result of this research it was recognized that Cabinet besides collecting the materials was study and developed issues of the history of Ukrainian art «from ancient times to the present», including Shevchenko as an artist, history of architecture and music. Moreover, members of Cabinet prepared materials for encyclopedias, and dictionaries of Ukrainian art History, involved in the museum activity in Kyiv and Moscow, popularized Ukrainian art.

  14. Cabinet Appointment in Uruguay: Legislative Strategy, hierarchy of portfolio and party affiliation of ministers

    Directory of Open Access Journals (Sweden)

    Daniel CHASQUETTI

    2013-07-01

    Full Text Available The article analyzes the formation and change of presidential cabinets in Uruguay during the period 1985-2010. In the first section we present the institutional and political features of the process of appointment and resignation of the ministers. The second section describes the cabinets formed in this period and shows that presidents have exchanged seats in cabinet by legislative support. The third section analyzes the political attributes of the ministers appointed (party affiliation, previous experience and the type of linkage that they keep with the president. The fourth analyze the relationship between the time survival of the individuals in office, the political responsibility in front of congress and the existence of a legislative majority that support the president. The last section describes the Uruguayan pattern of ministerial designation based in (i the establishment of an order of importance of portfolios, (ii the nomination of individuals with party affiliation (weather insider or adherent politicians and (iii the influence of the legislative support in defining the ministerial team.

  15. DEVELOPMENT OF PROTOTYPE SYSTEM FOR REGULATING THERMAL CONDITIONS OF TELECOMMUNICATIONS EQUIPMENT CABINETS

    Directory of Open Access Journals (Sweden)

    A. T. Rashidkhanov

    2017-01-01

    Full Text Available Objectives. The main objective of the study was to regulate the thermal regime and ensure the reliability of electronic equipmentMethods. In order to conduct experimental studies of the thermoelectric cooling system using heat pipes, a stand was assembled on which the developed and manufactured prototype was studied. The object of the experimental studies was a prototype cooling system, consisting of a thermoelectric battery made of conventional unified thermoelectric materials of ICE-71 type. The solution of the research problems carried out by the method of reduction to ordinary differential equations (Kantorovich method provides acceptable accuracy for such a class of problems.Results. A design of a telecommunication equipment cabinet with a thermal management system based on the use of heat pipes and thermoelectric cooling units is proposed. A mathematical model for the determination of the thermal field in the cabinet volume is considered; an experimental stand for the prototype study is described; the results of experimental studies for various power sources of heat release are presented.Conclusion. Experimental studies confirm the operability of the developed cooling system for cabinets with telecommunication equipment; this cooling method has advantages over conventional forced or natural cooling; the temperature in the block volume and the peak values of the heat sources are significantly reduced; at dissipation powers on one board within 50 W there is no need to use special means to remove heat from hot junctions of the thermoelectric battery.

  16. Preferred Residential kitchen cabinets Cover Models: The Case of the province of Artvin

    Directory of Open Access Journals (Sweden)

    Abdi Atılgan

    2012-11-01

    Full Text Available In this study, residential kitchen cabinets today and should be preferred to determine the reasons for the cover models were investigated. The study of urban settlement area of ​​the province of Artvin, the different socio-economic (lower / middle / upper SES levels, cuisine sampling method was chosen families. Data were obtained from the poll and systematic observation. Determination of the outstanding elements of the study and interpretation of the choice of species to cover some of the statistical techniques used. According to the results, residential kitchen cabinets, the most multi-chipboard / mdflam cover (25%, aluminum framed door is at least (1.09% were used. Reasons to prefer the technological developments and the launch of new products, while effective proposals were received by property owners, manufacturers, cover models, significantly affects the reasons for cost differences should be preferred. Another important result, is a form of property owners to ensure the kitchen cabinets. Accordingly, the vast majority of users provided by way of kitchen furniture, in order, while the other places and provided in the reinforcing elements are usually prepared production are known.

  17. [The art cabinet and its current significance. Museum establishment of natural history in early modern times].

    Science.gov (United States)

    Felfe, Robert

    2008-01-01

    For some time a hightened interest in so-called "curiosity cabinets" of the 16th to 18th century has surfaced in the historical sciences as well as in exhibitions with popular appeal, the arts and literature. Johann Laurentius Bausch was among those who assembled such a collection of natural history objects and artefacts. His curiosity cabinet was closely connected to his far more famous library and in his last will Bausch attempted to safeguard the coherence of the two. Against this background the article accentuates some of the aspects of his work from a perspective of a history of collections. One focus will thereby be on the practice of collecting as seemingly contradictory, being characterised on the one hand by the preservation of ancient knowledge as well as by scientific research based on specific objects. Another focus will be on curiosity cabinets as important platforms of exchange and means of social advancement. For the Academia Naturae Curiosorum exhibition objects and their publication were an important device of achieving recognition and protection from the Emperor's Court.

  18. Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.

    Science.gov (United States)

    Pugsley, Michael K; Curtis, Michael J; Hayes, Eric S

    2015-01-01

    Cardiac safety pharmacology is a continuously evolving discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment of a new chemical entity (NCE). The aim of cardiac safety pharmacology is to characterise the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects on the heart using continuously evolving methodology. Unlike Toxicology, safety pharmacology includes within its remit a regulatory requirement to predict the risk of rare cardiotoxic (potentially lethal) events such as torsades de pointes (TdP), which is statistically associated with drug-induced changes in the QT interval of the ECG due to blockade of I Kr or K v11.1 current encoded by hERG. This gives safety pharmacology its unique character. The key issues for the safety pharmacology assessment of a drug on the heart are detection of an adverse effect liability, projection of the data into safety margin calculation and clinical safety monitoring. This chapter will briefly review the current cardiac safety pharmacology paradigm outlined in the ICH S7A and ICH S7B guidance documents and the non-clinical models and methods used in the evaluation of new chemical entities in order to define the integrated risk assessment for submission to regulatory authorities. An overview of how the present cardiac paradigm was developed will be discussed, explaining how it was based upon marketing authorisation withdrawal of many non-cardiovascular compounds due to unanticipated proarrhythmic effects. The role of related biomarkers (of cardiac repolarisation, e.g. prolongation of the QT interval of the ECG) will be considered. We will also provide an overview of the 'non-hERG-centric' concepts utilised in the evolving comprehensive in vitro proarrhythmia assay (CIPA) that details conduct of the proposed ion channel battery test, use of human stem cells and application of in silico models to early cardiac safety

  19. Silica diatom shells tailored with Au nanoparticles enable sensitive analysis of molecules for biological, safety and environment applications

    KAUST Repository

    Onesto, V.

    2018-04-19

    Diatom shells are a natural, theoretically unlimited material composed of silicon dioxide, with regular patterns of pores penetrating through their surface. For their characteristics, diatom shells show promise to be used as low cost, highly efficient drug carriers, sensor devices or other micro-devices. Here, we demonstrate diatom shells functionalized with gold nanoparticles for the harvesting and detection of biological analytes (bovine serum albumin—BSA) and chemical pollutants (mineral oil) in low abundance ranges, for applications in bioengineering, medicine, safety, and pollution monitoring.

  20. Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni).

    Science.gov (United States)

    Pawlus, Alison D; Kinghorn, Douglas A

    2007-12-01

    Morinda citrifolia, commonly called noni, has a long history as a medicinal plant and its use as a botanical dietary supplement has grown tremendously in recent years. This has prompted a concomitant increase in research on the phytochemical constituents and biological activity of noni. A relatively large number of scientific publications on noni have been published in recent years, including a number of review articles. The goals of this review are to provide an updated categorization of the phytochemical constituents found in noni and to provide perspective for its extensive utilization as a major botanical dietary supplement. Included herein are a comprehensive list of known ethnobotanical uses and common names of M. citrifolia, a brief summary of relevant biological studies and a discussion of the safety of noni as a supplement.

  1. Biology

    Indian Academy of Sciences (India)

    I am particularly happy that the Academy is bringing out this document by Professor M S. Valiathan on Ayurvedic Biology. It is an effort to place before the scientific community, especially that of India, the unique scientific opportunities that arise out of viewing Ayurveda from the perspective of contemporary science, its tools ...

  2. Road pricing and road safety : possible effects on road safety of 23 variants of road pricing.

    NARCIS (Netherlands)

    Eenink, R.G. Dijkstra, A. Wijnen, W. & Janssen, S.T.M.C.

    2007-01-01

    The Nouwen Committee (National Platform Paying Differently for Mobility) advised the Cabinet in 2005 about the introduction of a system of road pricing. Part of this advice consisted of a calculation of the expected road safety effects of such a system. In a letter to the Minister of Transport, SWOV

  3. Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods

    Czech Academy of Sciences Publication Activity Database

    Žárská, Monika; Šrámek, Michal; Novotný, Filip; Havel, Filip; Babelova, A.; Mrázková, Blanka; Benada, Oldřich; Reiniš, Milan; Štěpánek, Ivan; Musílek, K.; Bartek, Jiří; Ursinyova, M.; Novák, Ondřej; Dzijak, Rastislav; Kuca, K.; Proška, J.; Hodný, Zdeněk

    2018-01-01

    Roč. 154 (2018), s. 275-290 ISSN 0142-9612 R&D Projects: GA ČR GA16-13967S; GA MŠk(CZ) LO1509; GA MŠk(CZ) LM2015062; GA MŠk LO1419 Institutional support: RVO:68378050 ; RVO:61388971 ; RVO:68378041 Keywords : Genotoxicity * Autophagy * Lysosomal stress * Spleen * Thrombocytes * Plasmonic photothermal effect Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 8.402, year: 2016

  4. On-line Monitoring Device for High-voltage Switch Cabinet Partial Discharge Based on Pulse Current Method

    Science.gov (United States)

    Y Tao, S.; Zhang, X. Z.; Cai, H. W.; Li, P.; Feng, Y.; Zhang, T. C.; Li, J.; Wang, W. S.; Zhang, X. K.

    2017-12-01

    The pulse current method for partial discharge detection is generally applied in type testing and other off-line tests of electrical equipment at delivery. After intensive analysis of the present situation and existing problems of partial discharge detection in switch cabinets, this paper designed the circuit principle and signal extraction method for partial discharge on-line detection based on a high-voltage presence indicating systems (VPIS), established a high voltage switch cabinet partial discharge on-line detection circuit based on the pulse current method, developed background software integrated with real-time monitoring, judging and analyzing functions, carried out a real discharge simulation test on a real-type partial discharge defect simulation platform of a 10KV switch cabinet, and verified the sensitivity and validity of the high-voltage switch cabinet partial discharge on-line monitoring device based on the pulse current method. The study presented in this paper is of great significance for switch cabinet maintenance and theoretical study on pulse current method on-line detection, and has provided a good implementation method for partial discharge on-line monitoring devices for 10KV distribution network equipment.

  5. Density, distribution, and genetic structure of grizzly bears in the Cabinet-Yaak Ecosystem

    Science.gov (United States)

    Macleod, Amy C.; Boyd, Kristina L.; Boulanger, John; Royle, J. Andrew; Kasworm, Wayne F.; Paetkau, David; Proctor, Michael F.; Annis, Kim; Graves, Tabitha A.

    2016-01-01

    The conservation status of the 2 threatened grizzly bear (Ursus arctos) populations in the Cabinet-Yaak Ecosystem (CYE) of northern Montana and Idaho had remained unchanged since designation in 1975; however, the current demographic status of these populations was uncertain. No rigorous data on population density and distribution or analysis of recent population genetic structure were available to measure the effectiveness of conservation efforts. We used genetic detection data from hair corral, bear rub, and opportunistic sampling in traditional and spatial capture–recapture models to generate estimates of abundance and density of grizzly bears in the CYE. We calculated mean bear residency on our sampling grid from telemetry data using Huggins and Pledger models to estimate the average number of bears present and to correct our superpopulation estimates for lack of geographic closure. Estimated grizzly bear abundance (all sex and age classes) in the CYE in 2012 was 48–50 bears, approximately half the population recovery goal. Grizzly bear density in the CYE (4.3–4.5 grizzly bears/1,000 km2) was among the lowest of interior North American populations. The sizes of the Cabinet (n = 22–24) and Yaak (n = 18–22) populations were similar. Spatial models produced similar estimates of abundance and density with comparable precision without requiring radio-telemetry data to address assumptions of geographic closure. The 2 populations in the CYE were demographically and reproductively isolated from each other and the Cabinet population was highly inbred. With parentage analysis, we documented natural migrants to the Cabinet and Yaak populations by bears born to parents in the Selkirk and Northern Continental Divide populations. These events supported data from other sources suggesting that the expansion of neighboring populations may eventually help sustain the CYE populations. However, the small size, isolation, and inbreeding documented by this study

  6. Biological preservation of plant derived animal feed with antifungal microorganisms: safety and formulation aspects.

    Science.gov (United States)

    Melin, Petter; Sundh, Ingvar; Håkansson, Sebastian; Schnürer, Johan

    2007-08-01

    During storage of moist animal feed, growth of detrimental fungi causing spoilage, or being mycotoxigenic or pathogenic, is a severe problem. Addition of biopreservative yeasts or lactic acid bacteria can significantly reduce this problem. However, their use requires several careful considerations. One is the safety to the animal, humans and the environment, tightly connected to legal aspects and the need for pre-market authorisation when supplementing feed with microorganisms. Although both yeasts and lactic acid bacteria are considered comparatively safe organisms due to low production of toxic metabolites, it is of great importance to understand the mechanisms behind the biopreservative abilities. Another important issue concerns practical aspects, such as the economic production of large amounts of the organisms and the development of a suitable formulation giving the organisms a long shelf life. These aspects are discussed and a recommendation of this review is that both safety and formulation aspects of a specific microbe should be considered at an early stage in the selection of new organisms with biopreservation potential.

  7. Building Design Guidelines of Interior Architecture for Bio safety Levels of Biology Laboratories

    International Nuclear Information System (INIS)

    ElDib, A.A.

    2014-01-01

    This paper discusses the pivotal role of the Interior Architecture As one of the scientific disciplines minute to complete the Architectural Sciences, which relied upon the achievement and development of facilities containing scientific research laboratories, in terms of planning and design, particularly those containing biological laboratories using radioactive materials, adding to that, the application of the materials or raw materials commensurate with each discipline of laboratory and its work nature, and by the discussion the processing of design techniques and requirements of interior architecture dealing with Research Laboratory for electronic circuits an their applications with the making of its prototypes

  8. 7th February 2011 - Scottish Cabinet Secretary for Education and Lifelong Learning M. Russell MSP signing the guest book with Beams Department Head P. Collier and Adviser J. Ellis

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    01-17:Scottish Cabinet Secretary for Education and Lifelong Learning M. Russell MSP signing the guest book with Beams Department Head P. Collier and Adviser J. Ellis 18-22: Teachers and Pupils signing the guest book 23-27: visiting the CERN control centre with P. Collier 28-32: visiting the LHCb underground area 33-74: visitng the ATLAS underground area Other members of the delegation: Chief Scientific Adviser to the Scottish Government and Chair in Molecular and Cell Biology at the University of Aberdeen A. Glover; Assistant Private Secretary M. Gallagher; Associate Director Institute for Gravitational Research, University of Glasgow J.Hough.

  9. Further research on the biological activities and the safety of raspberry ketone is needed

    Directory of Open Access Journals (Sweden)

    Jungmin Lee

    2016-03-01

    Full Text Available Raspberry ketone supplements have grabbed consumer attention with the possibility that they might help burn fat and aid weight loss. While raspberry ketone occurs naturally, and is found in raspberry fruit, most is synthetically produced for use in commercial products as flavorings, fragrances, or dietary supplements. Currently, the amount of raspberry ketone in dietary supplements (currently sold in the US is well above the maximum concentration recommended for food and fragrance products, so additional toxicology work is needed to ensure that such concentrations of raspberry ketone are safe. In addition to safety data, clinical studies are also needed to validate any health benefits. Without research on the effects of consuming high concentrations of raspberry ketone, consumers should be wary of unsubstantiated claims and mindful of potential harm to their health.

  10. CTLA-4 blockade with ipilimumab: biology, safety, efficacy, and future considerations

    International Nuclear Information System (INIS)

    Camacho, Luis H

    2015-01-01

    Melanoma remains a critical public health problem worldwide. Patients with stage IV disease have very poor prognosis and their 1-year survival rate is only 25%. Until recently, systemic treatments with a positive impact on overall survival (OS) had remained elusive. In recent years, the United States Food and Drug Administration (FDA) – approved several novel agents targeting the RAS/RAF/MEK/ERK pathway (vemurafenib, dabrafenib, and trametinib) – critical in cell division and proliferation of melanoma, and an immune checkpoint inhibitor (ipilimumab) directed against the cytotoxic T lymphocyte Antigen - (CTLA-4). Moreover, recent reports of clinical trials studying other immune checkpoint modulating agents will most likely result in their FDA approval within the next months. This review focuses on ipilimumab, its safety and efficacy, and future considerations. Ipilimumab has demonstrated a positive OS impact after a several-year follow-up. It is also recognized that due to its mechanism of action, the response patterns to ipilimumab can differ from those observed in patients following treatment with conventional cytotoxic agents and even the most recently approved BRAF inhibitors. Most patients (84.8%) experience drug-related adverse events (AEs) of any grade; most of these are mild to moderate and immune mediated. However, a minority of patients may also experience severe and life-threatening AEs. In clinical studies, AEs were managed according to guidelines that emphasized close clinical monitoring and early use of corticosteroids when appropriate. Preliminary results have taught us the potential greater toxicity when in combination with vemurafenib, and the greater antitumor efficacy when combined with nivolumab, a monoclonal antibody directed against programmed death receptor-1 (PD-1), another immune checkpoint inhibitor. Future challenges include the optimization of dosing and toxicities when used as a single agent, and studying the safety and efficacy of

  11. SAFETY

    CERN Multimedia

    C. Schaefer and N. Dupont

    2013-01-01

      “Safety is the highest priority”: this statement from CERN is endorsed by the CMS management. An interpretation of this statement may bring you to the conclusion that you should stop working in order to avoid risks. If the safety is the priority, work is not! This would be a misunderstanding and misinterpretation. One should understand that “working safely” or “operating safely” is the priority at CERN. CERN personnel are exposed to different hazards on many levels on a daily basis. However, risk analyses and assessments are done in order to limit the number and the gravity of accidents. For example, this process takes place each time you cross the road. The hazard is the moving vehicle, the stake is you and the risk might be the risk of collision between both. The same principle has to be applied during our daily work. In particular, keeping in mind the general principles of prevention defined in the late 1980s. These principles wer...

  12. SAFETY

    CERN Multimedia

    M. Plagge, C. Schaefer and N. Dupont

    2013-01-01

    Fire Safety – Essential for a particle detector The CMS detector is a marvel of high technology, one of the most precise particle measurement devices we have built until now. Of course it has to be protected from external and internal incidents like the ones that can occur from fires. Due to the fire load, the permanent availability of oxygen and the presence of various ignition sources mostly based on electricity this has to be addressed. Starting from the beam pipe towards the magnet coil, the detector is protected by flooding it with pure gaseous nitrogen during operation. The outer shell of CMS, namely the yoke and the muon chambers are then covered by an emergency inertion system also based on nitrogen. To ensure maximum fire safety, all materials used comply with the CERN regulations IS 23 and IS 41 with only a few exceptions. Every piece of the 30-tonne polyethylene shielding is high-density material, borated, boxed within steel and coated with intumescent (a paint that creates a thick co...

  13. EVALUATION OF BIOLOGICAL SAFETY OF MILK ON BIOENERGETIC STATUS OF COWS

    Directory of Open Access Journals (Sweden)

    K. Leshukov

    2012-06-01

    Full Text Available The obtained data allow to argue about existence of close correlation between the content in milk of somatic cages and existence in it various compound substances. The raised number of somatic cages as the most sensitive indicator, allows to catch changes in a chemical composition of a secret of an udder, that is signals about fall of dairy efficiency. However the increase in number of somatic cages can be caused and other factors, in particular approach of the last stage of pregnancy. It is established that on level of capacity of biologically active centers of cows it is possible to estimate with a high share of probability quantity of somatic cages in milk for the purpose of further technological differentiation of milk raw materials.

  14. Optimum carrageenan concentration improved the physical properties of cabinet-dried yoghurt powder

    Science.gov (United States)

    Pratama, Y.; Abduh, S. B. M.; Legowo, A. M.; Pramono, Y. B.; Albaarri, AN

    2018-01-01

    Carrageenan is a hydrocolloid which able to improve the characteristic of dried powder. The purpose of this study was to produce and evaluate the characteristics of yoghurt powder which incorporated carrageenan as stabilizer and dried in a cabinet dryer. Carrageenan of 1 %, 2 % and 3 % (w/v) concentration were added to yoghurt prior to cabinet drying process. Physical properties of the yoghurt powder and the reconstituted one were evaluated. The best result was shown in carrageenan concentration of 2 % where it showed the highest bulk density (0.62 g/ml), and best particle size distribution (65.49 % in the range of 250-500 μm). Moisture and water activity (aw) were 8.02% and 0.37, respectively. The value is lower than what spoilage microorganisms require to grow (aw > 0.6) thus ensuring its long shelf life when combined with proper packaging. Reconstitution at 50°C showed that 2 % carrageenan resulted in a stable yoghurt product with no visible syneresis even after 3 hours. The proposed method shows promising application in the production of long shelf-life yoghurt powder production.

  15. Vibroacoustic Analysis of a Refrigerator Freezer Cabinet Coupled with an Air Duct

    Directory of Open Access Journals (Sweden)

    Onur Çelikkan

    2017-01-01

    Full Text Available In this study, the vibration and acoustic interactions between the structure and the cavity inside the freezer cabinet were investigated. Thus, a set of numerical and experimental analyses were performed. In the numerical analysis, the acoustic characteristics of the freezer cavity were solved, and the mixed finite element method was then implemented to analyse the coupled behaviour of the cavity with the air duct using the Acoustic Fluid-Structure Interaction (AFSI technique. In the experimental analyses, an acoustic modal analysis of the freezer cavity and a structural modal analysis of the air duct were performed for the validation process. A good agreement was obtained among the results. Thus, the accuracy of the numerical model was confirmed. The validated models were used for optimizing the design. To solve the noise generation mechanism inside the freezer cabinet, the noise primarily generated by the freezer fan unit was measured under normal working conditions of the refrigerator, and the resonance frequencies were obtained. This information was compared with the normal modes of the air duct, and the overlapping frequencies were identified. To reduce the interaction between the source and the structure, a few design modifications were applied to the air duct. Thus, the structural-borne noise radiating from the air duct into the freezer cavity was reduced.

  16. CABINETS OPERATING RULES AND COALITIONN FORMATION IN CENTRAL AND EASTERN EUROPE

    Directory of Open Access Journals (Sweden)

    DANA IRINA IONITA

    2011-04-01

    Full Text Available After the fall of communism in the late ’80 in Central and Eastern Europe, due to the appearance of several political parties in each state, there was the need to form coalitions in order to provide support for the governments. This paper aims to identify the institutional features that influence the coalition formation process using the rational choice institutionalism approach. In this case, the political parties, who seek to optimize their benefits in the government formation process, are constrained by the institutional environment. The institutional environment comprises the rules that determine how the governments are formed. Particularly, this paper aim is to identify how the cabinet operating rules affect the outcomes of the coalition formation process. In order to do so, I will develop a quantitative analysis of 110 cabinets in Estonia, Latvia, Lithuania, Poland, Czech Republic, Slovakia, Hungary, Slovenia, Romania and Bulgaria formed after the first free elections subsequent to the communist fall until the beginning of 2010. These countries represent the post-communist states that joined the European Union, finalizing the democratization process at least from a formal point a view. This cross-country comparison tries to explain how some institutional features influence the formation of coalitions in new democracies. This research is valuable due to the lack of this type of comparative studies on Central and Eastern European states.

  17. Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation.

    Science.gov (United States)

    Shinde, Vaibhav; Klima, Stefanie; Sureshkumar, Perumal Srinivasan; Meganathan, Kesavan; Jagtap, Smita; Rempel, Eugen; Rahnenführer, Jörg; Hengstler, Jan Georg; Waldmann, Tanja; Hescheler, Jürgen; Leist, Marcel; Sachinidis, Agapios

    2015-06-17

    Efficient protocols to differentiate human pluripotent stem cells to various tissues in combination with -omics technologies opened up new horizons for in vitro toxicity testing of potential drugs. To provide a solid scientific basis for such assays, it will be important to gain quantitative information on the time course of development and on the underlying regulatory mechanisms by systems biology approaches. Two assays have therefore been tuned here for these requirements. In the UKK test system, human embryonic stem cells (hESC) (or other pluripotent cells) are left to spontaneously differentiate for 14 days in embryoid bodies, to allow generation of cells of all three germ layers. This system recapitulates key steps of early human embryonic development, and it can predict human-specific early embryonic toxicity/teratogenicity, if cells are exposed to chemicals during differentiation. The UKN1 test system is based on hESC differentiating to a population of neuroectodermal progenitor (NEP) cells for 6 days. This system recapitulates early neural development and predicts early developmental neurotoxicity and epigenetic changes triggered by chemicals. Both systems, in combination with transcriptome microarray studies, are suitable for identifying toxicity biomarkers. Moreover, they may be used in combination to generate input data for systems biology analysis. These test systems have advantages over the traditional toxicological studies requiring large amounts of animals. The test systems may contribute to a reduction of the costs for drug development and chemical safety evaluation. Their combination sheds light especially on compounds that may influence neurodevelopment specifically.

  18. Human biology-based drug safety evaluation: scientific rationale, current status and future challenges.

    Science.gov (United States)

    Kenna, J Gerry

    2017-05-01

    Animal toxicity studies used to assess the safety of new candidate pharmaceuticals prior to their progression into human clinical trials are unable to assess the risk of non-pharmacologically mediated idiosyncratic adverse drug reactions (ADRs), the most frequent of which are drug-induced liver injury and cardiotoxicity. Idiosyncratic ADRs occur only infrequently and in certain susceptible humans, but are caused by many hundreds of different drugs and may lead to serious illness. Areas covered: Idiosyncratic ADRs are initiated by drug-related chemical insults, which cause toxicity due to susceptibility factors that manifest only in certain patients. The chemical insults can be detected using in vitro assays. These enable useful discrimination between drugs that cause high versus low levels of idiosyncratic ADR concern. Especially promising assays, which have been described recently in peer-reviewed scientific literature, are highlighted. Expert opinion: Effective interpretation of in vitro toxicity data requires integration of endpoints from multiple assays, which each address different mechanisms, and must also take account of human systemic and tissue drug exposure in vivo. Widespread acceptance and use of such assays has been hampered by the lack of correlation between idiosyncratic human ADR risk and toxicities observed in vivo in animals.

  19. Door and cabinet recognition using convolutional neural nets and real-time method fusion for handle detection and grasping

    DEFF Research Database (Denmark)

    Maurin, Adrian Llopart; Ravn, Ole; Andersen, Nils Axel

    2017-01-01

    In this paper we present a new method that robustly identifies doors, cabinets and their respective handles, with special emphasis on extracting useful features from handles to be then manipulated. The novelty of this system relies on the combination of a Convolutional Neural Net (CNN), as a form...... of reducing the search space, several methods to extract point cloud data and a mobile robot to interact with the objects. The framework consists of the following components: The implementation of a CNN to extract a Region of Interest (ROI) from an image corresponding to a door or cabinet. Several vision...

  20. Biological effects and physical safety aspects of NMR imaging and in vivo spectroscopy

    International Nuclear Information System (INIS)

    Tenforde, T.S.; Budinger, T.F.

    1985-08-01

    An assessment is made of the biological effects and physical hazards of static and time-varying fields associated with the NMR devices that are being used for clinical imaging and in vivo spectroscopy. A summary is given of the current state of knowledge concerning the mechanisms of interaction and the bioeffects of these fields. Additional topics that are discussed include: (1) physical effects on pacemakers and metallic implants such as aneurysm clips, (2) human health studies related to the effects of exposure to nonionizing electromagnetic radiation, and (3) extant guidelines for limiting exposure of patients and medical personnel to the fields produced by NMR devices. On the basis of information available at the present time, it is concluded that the fields associated with the current generation of NMR devices do not pose a significant health risk in themselves. However, rigorous guidelines must be followed to avoid the physical interaction of these fields with metallic implants and medical electronic devices. 476 refs., 5 figs., 2 tabs

  1. Study on biological effect on mice and use safety of 830 nm semiconductor laser

    International Nuclear Information System (INIS)

    Li Keqiu; Li Jian; Miao Xuhong; Liu Shujuan; Li Guang

    2006-01-01

    Objective: To study biological effect on mice by 830 nm semiconductor laser in different dosage, and determine the optimal irradiating dosage by observing and analyzing the immunoregulation and cytogenetical damage of mice after irradiation. Methods: The spleen and thymus areas of Kunming mice were irradiated in vitro by 830 nm semiconductor laser of 30 mW for 5 min, 10 min and 20 min per day respectively, then the blood samples were collected from orbital vein. Further, the spleen tissue and sternum marrow were collected soon after the mice were killed. Afterwards, IgG, dopamine, serotonin in serum were detected respectively. Besides these, the rate of lymphocyte transformation and the rate of micronuclei in marrow polychromatic erythrocytes were also determined. Results: With the extending of irradiating time, the detected factors changed differently. Statistically, there were differences in IgG concentration and the rate of lymphocyte transformation between 10 min group, 20 min group and control group respectively, but no difference between each experimental group were found. /compare with control group, serotonin concentration in 10 min group increased, and there was statistical difference between these two groups, while there was no difference in dopamine concentration among each group. Besides these, the rate of micronuclei in 20 min group increased. Conclusion: In this study, irradiation by semiconductor laser for appropriate time can improve immuno function of mice, but irradiation in high dosage will result in the damage of genetic material. The optimal time of irradiation by 830 nm semiconductor laser was 10 min. (authors)

  2. Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

    Science.gov (United States)

    Kishimoto, Takashi K.; Ferrari, Joseph D.; Lamothe, Robert A.; Kolte, Pallavi N.; Griset, Aaron P.; O'Neil, Conlin; Chan, Victor; Browning, Erica; Chalishazar, Aditi; Kuhlman, William; Fu, Fen-Ni; Viseux, Nelly; Altreuter, David H.; Johnston, Lloyd; Maldonado, Roberto

    2016-10-01

    The development of antidrug antibodies (ADAs) is a common cause for the failure of biotherapeutic treatments and adverse hypersensitivity reactions. Here we demonstrate that poly(lactic-co-glycolic acid) (PLGA) nanoparticles carrying rapamycin, but not free rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that is characterized by the induction of tolerogenic dendritic cells, an increase in regulatory T cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen-specific hypersensitivity reactions. Intravenous co-administration of tolerogenic nanoparticles with pegylated uricase inhibited the formation of ADAs in mice and non-human primates and normalized serum uric acid levels in uricase-deficient mice. Similarly, the subcutaneous co-administration of nanoparticles with adalimumab resulted in the durable inhibition of ADAs, leading to normalized pharmacokinetics of the anti-TNFα antibody and protection against arthritis in TNFα transgenic mice. Adjunct therapy with tolerogenic nanoparticles represents a novel and broadly applicable approach to prevent the formation of ADAs against biologic therapies.

  3. Biological effects and physical safety aspects of NMR imaging and in vivo spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tenforde, T.S.; Budinger, T.F.

    1985-08-01

    An assessment is made of the biological effects and physical hazards of static and time-varying fields associated with the NMR devices that are being used for clinical imaging and in vivo spectroscopy. A summary is given of the current state of knowledge concerning the mechanisms of interaction and the bioeffects of these fields. Additional topics that are discussed include: (1) physical effects on pacemakers and metallic implants such as aneurysm clips, (2) human health studies related to the effects of exposure to nonionizing electromagnetic radiation, and (3) extant guidelines for limiting exposure of patients and medical personnel to the fields produced by NMR devices. On the basis of information available at the present time, it is concluded that the fields associated with the current generation of NMR devices do not pose a significant health risk in themselves. However, rigorous guidelines must be followed to avoid the physical interaction of these fields with metallic implants and medical electronic devices. 476 refs., 5 figs., 2 tabs.

  4. The British Society for Rheumatology Biologics Registers in Ankylosing Spondylitis (BSRBR-AS) study: Protocol for a prospective cohort study of the long-term safety and quality of life outcomes of biologic treatment.

    Science.gov (United States)

    Macfarlane, Gary J; Barnish, Maxwell S; Jones, Elizabeth A; Kay, Lesley; Keat, Andrew; Meldrum, Karen T; Pathan, Ejaz; Sturrock, Roger D; Zabke, Claudia; McNamee, Paul; Jones, Gareth T

    2015-11-11

    Axial spondyloarthropathy typically has its onset in early adulthood and can impact significantly on quality of life. In the UK, biologic anti-tumour necrosis factor therapy is recommended for patients who are unresponsive to non-steroidal anti-inflammatory drugs. There remain several unresolved issues about the long-term safety and quality of life outcomes of biologic treatment in axial spondyloarthropathy. Long-term "real-world" surveillance data are required to complement data from randomised controlled trials. We are conducting a UK-wide prospective cohort study of patients with axial spondyloarthropathy who are naïve to biologic therapy at the time of recruitment. Those about to commence anti-tumour necrosis factor biologic therapy will enter a "biologic" sub-cohort with other patients assigned to a "non-biologic" sub-cohort. The primary objective is to determine whether the use of biologic therapy is associated with an increased risk of serious infection, while secondary objectives are to assess differences in malignancy, serious comorbidity, all-cause mortality but also assess impact on specific clinical domains (physical health, mental health and quality of life) including work outcomes between biologic and non-biologic patient cohorts. Patients will be followed-up for up to 5 years. Data are obtained at baseline and at standard clinical follow-up visits - at 3, 6 and 12 months and then annually for the biologic cohort and annually for the non-biologic cohort. This study will also collect biological samples for genetic analysis. Although biologic therapy is widely used for ankylosing spondylitis patients who are unresponsive to non-steroidal anti-inflammatory drugs, the majority of the available safety information comes from rheumatoid arthritis, where increased infection risk has consistently been shown. However, given the typical demographic differences between rheumatoid arthritis and axial spondyloarthropathy patients, it is important to develop an

  5. Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania

    DEFF Research Database (Denmark)

    Massaga, J J; Lusingu, J P; Makunde, R

    2008-01-01

    -immune healthy adult male volunteers with and without malaria parasites. The objective was to collect data on biological and haematological safety, tolerability, and parasitological efficacy to serve as baseline in the evaluation of the effectiveness of AQ preventive intermittent treatment against malaria...

  6. Introducing Mammalian Cell Culture and Cell Viability Techniques in the Undergraduate Biology Laboratory.

    Science.gov (United States)

    Bowey-Dellinger, Kristen; Dixon, Luke; Ackerman, Kristin; Vigueira, Cynthia; Suh, Yewseok K; Lyda, Todd; Sapp, Kelli; Grider, Michael; Crater, Dinene; Russell, Travis; Elias, Michael; Coffield, V McNeil; Segarra, Verónica A

    2017-01-01

    Undergraduate students learn about mammalian cell culture applications in introductory biology courses. However, laboratory modules are rarely designed to provide hands-on experience with mammalian cells or teach cell culture techniques, such as trypsinization and cell counting. Students are more likely to learn about cell culture using bacteria or yeast, as they are typically easier to grow, culture, and manipulate given the equipment, tools, and environment of most undergraduate biology laboratories. In contrast, the utilization of mammalian cells requires a dedicated biological safety cabinet and rigorous antiseptic techniques. For this reason, we have devised a laboratory module and method herein that familiarizes students with common cell culture procedures, without the use of a sterile hood or large cell culture facility. Students design and perform a time-efficient inquiry-based cell viability experiment using HeLa cells and tools that are readily available in an undergraduate biology laboratory. Students will become familiar with common techniques such as trypsinizing cells, cell counting with a hemocytometer, performing serial dilutions, and determining cell viability using trypan blue dye. Additionally, students will work with graphing software to analyze their data and think critically about the mechanism of death on a cellular level. Two different adaptations of this inquiry-based lab are presented-one for non-biology majors and one for biology majors. Overall, these laboratories aim to expose students to mammalian cell culture and basic techniques and help them to conceptualize their application in scientific research.

  7. Touching Anatomy. : On the Handling of Anatomical Preparations in the Anatomical Cabinets of Frederik Ruysch (1638-1731)

    NARCIS (Netherlands)

    Knoeff, Rina

    2015-01-01

    This paper argues that the anatomical Cabinets of Dutch anatomist Frederik Ruysch must be understood as an early modern workshop in which preparations were continuously handled. It is claimed that preparations actively appealed to anatomists and visitors to handle, re-dissect, touch, and even kiss

  8. [BETWEEN HORROR AND SCIENCE: THE BIRTH OF A CABINET OF PATHOLOGICAL ANATHOMY AT THE UNIVERSITY OF PALERMO].

    Science.gov (United States)

    Craxí, Lucia; Maresi, Emiliano; Franco, Vito

    2014-01-01

    This paper outlines the history of the Cabinet of Pathological Anathomy at the University of Palermo, describes rapidly its current status and analyzes the composition of its displays in 1859. It aims to highlight the analogies with other collections of a similar kind and to pinpoint potential actions to endorse and develop this important scientific asset.

  9. Solar thermal drying of apricots: Effect of spectrally-selective cabinet materials on drying rate and quality metrics (abstract)

    Science.gov (United States)

    Solar thermal (ST) drying is currently not in widespread commercial use due to concerns about slow drying rates and poor product quality. ST dryer cabinets could be constructed from spectrally-selective materials (materials which transmit only certain sunlight wavelength bands), but these types of ...

  10. Meeting Summary of Kitchen Cabinet on Financial Due Diligence to Reduce Proliferation Risks

    Energy Technology Data Exchange (ETDEWEB)

    Hund, Gretchen [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weise, Rachel A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carr, Geoffrey A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-08-15

    The U.S. Department of Energy’s Pacific Northwest National Laboratory convened the Kitchen Cabinet (KC) to facilitate a candid discussion about the role of financial institutions (FIs) in antiproliferation efforts to reduce nuclear proliferation risks by identifying suspicious business transactions and exports when making lending or insurance decisions. The meeting brought together a group of export control specialists, largely representatives from the Nuclear Suppliers Group (NSG) Participating Governments (PGs) and finance experts representing banks and insurance companies. By assembling a KC of experts, the group could understand what suspicious transactions look like from each other’s perspectives and better inform each of their operations. The goal was to develop red flags FIs could use to identify suspicious proliferation-related transactions and to help governments gain a clearer picture of proliferation using financial information.

  11. Quality Model of Foodstuff in the Control of Refrigerated Display Cabinet

    DEFF Research Database (Denmark)

    Cai, Junping; Risum, Jørgen; Thybo, Claus

    2006-01-01

    as what is the optimal defrost scheme from food quality point of view are answered. This will serve as a prerequisite of designing of optimal control scheme for the commercial refrigeration system, aiming at optimizing a weighed cost function of both food quality and overall energy consumption of system.......Commercial refrigerating systems need to be defrosted regularly to maintain a satisfactory performance. When defrosting the evaporator coil, the air temperature inside the display cabinet will increase, and float outside the normal temperature range for a period of time, the question is what...... happens to the food inside during this period, when we look at the quality factor? This paper discusses quality model of foodstuff, different scenarios of defrost scheme are simulated, questions such as how the defrost temperature and duration influence the food temperature, thus the food quality, as well...

  12. Transcriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat show phenotypic plasticity

    Directory of Open Access Journals (Sweden)

    Guevara David R

    2012-10-01

    Full Text Available Abstract Background Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundance when grown under controlled environmental conditions. However, few reports assess the capacity of plants to display stress-responsive traits in natural habitats where concurrent stresses are the norm. Results To determine whether stress-responsive changes observed in cabinet-grown plants are recapitulated in the field, we analyzed leaf transcript and metabolic profiles of Thellungiella growing in its native Yukon habitat during two years of contrasting meteorological conditions. We found 673 genes showing differential expression between field and unstressed, chamber-grown plants. There were comparatively few overlaps between genes expressed under field and cabinet treatment-specific conditions. Only 20 of 99 drought-responsive genes were expressed both in the field during a year of low precipitation and in plants subjected to drought treatments in cabinets. There was also a general pattern of lower abundance among metabolites found in field plants relative to control or stress-treated plants in growth cabinets. Nutrient availability may explain some of the observed differences. For example, proline accumulated to high levels in cold and salt-stressed cabinet-grown plants but proline content was, by comparison, negligible in plants at a saline Yukon field site. We show that proline accumulated in a stress-responsive manner in Thellungiella plants salinized in growth cabinets and in salt-stressed seedlings when nitrogen was provided at 1.0 mM. In seedlings grown on 0.1 mM nitrogen medium, the proline content was low while carbohydrates increased. The relatively higher content of sugar-like compounds in field plants and seedlings on low nitrogen

  13. Transcriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat show phenotypic plasticity.

    Science.gov (United States)

    Guevara, David R; Champigny, Marc J; Tattersall, Ashley; Dedrick, Jeff; Wong, Chui E; Li, Yong; Labbe, Aurelie; Ping, Chien-Lu; Wang, Yanxiang; Nuin, Paulo; Golding, G Brian; McCarry, Brian E; Summers, Peter S; Moffatt, Barbara A; Weretilnyk, Elizabeth A

    2012-10-01

    Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundance when grown under controlled environmental conditions. However, few reports assess the capacity of plants to display stress-responsive traits in natural habitats where concurrent stresses are the norm. To determine whether stress-responsive changes observed in cabinet-grown plants are recapitulated in the field, we analyzed leaf transcript and metabolic profiles of Thellungiella growing in its native Yukon habitat during two years of contrasting meteorological conditions. We found 673 genes showing differential expression between field and unstressed, chamber-grown plants. There were comparatively few overlaps between genes expressed under field and cabinet treatment-specific conditions. Only 20 of 99 drought-responsive genes were expressed both in the field during a year of low precipitation and in plants subjected to drought treatments in cabinets. There was also a general pattern of lower abundance among metabolites found in field plants relative to control or stress-treated plants in growth cabinets. Nutrient availability may explain some of the observed differences. For example, proline accumulated to high levels in cold and salt-stressed cabinet-grown plants but proline content was, by comparison, negligible in plants at a saline Yukon field site. We show that proline accumulated in a stress-responsive manner in Thellungiella plants salinized in growth cabinets and in salt-stressed seedlings when nitrogen was provided at 1.0 mM. In seedlings grown on 0.1 mM nitrogen medium, the proline content was low while carbohydrates increased. The relatively higher content of sugar-like compounds in field plants and seedlings on low nitrogen media suggests that Thellungiella shows

  14. Transcriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat show phenotypic plasticity

    Science.gov (United States)

    2012-01-01

    Background Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundance when grown under controlled environmental conditions. However, few reports assess the capacity of plants to display stress-responsive traits in natural habitats where concurrent stresses are the norm. Results To determine whether stress-responsive changes observed in cabinet-grown plants are recapitulated in the field, we analyzed leaf transcript and metabolic profiles of Thellungiella growing in its native Yukon habitat during two years of contrasting meteorological conditions. We found 673 genes showing differential expression between field and unstressed, chamber-grown plants. There were comparatively few overlaps between genes expressed under field and cabinet treatment-specific conditions. Only 20 of 99 drought-responsive genes were expressed both in the field during a year of low precipitation and in plants subjected to drought treatments in cabinets. There was also a general pattern of lower abundance among metabolites found in field plants relative to control or stress-treated plants in growth cabinets. Nutrient availability may explain some of the observed differences. For example, proline accumulated to high levels in cold and salt-stressed cabinet-grown plants but proline content was, by comparison, negligible in plants at a saline Yukon field site. We show that proline accumulated in a stress-responsive manner in Thellungiella plants salinized in growth cabinets and in salt-stressed seedlings when nitrogen was provided at 1.0 mM. In seedlings grown on 0.1 mM nitrogen medium, the proline content was low while carbohydrates increased. The relatively higher content of sugar-like compounds in field plants and seedlings on low nitrogen media suggests that

  15. Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

    Directory of Open Access Journals (Sweden)

    Correard F

    2014-11-01

    Full Text Available Florian Correard,1,2 Ksenia Maximova,3 Marie-Anne Estève,1,2 Claude Villard,1 Myriam Roy,4 Ahmed Al-Kattan,3 Marc Sentis,3 Marc Gingras,4 Andrei V Kabashin,3 Diane Braguer1,2 1Aix Marseille Université, INSERM, CR02 UMR_S911, Marseille, France; 2APHM, Hôpital Timone, Marseille, France; 3Aix Marseille Université, CNRS, LP3 UMR 7341, Marseille, France; 4Aix Marseille Université, CNRS, CINAM, UMR 7325 Marseille, France Abstract: Due to excellent biocompatibility, chemical stability, and promising optical properties, gold nanoparticles (Au-NPs are the focus of research and applications in nanomedicine. Au-NPs prepared by laser ablation in aqueous biocompatible solutions present an essentially novel object that is unique in avoiding any residual toxic contaminant. This paper is conceived as the next step in development of laser-ablated Au-NPs for future in vivo applications. The aim of the study was to assess the safety, uptake, and biological behavior of laser-synthesized Au-NPs prepared in water or polymer solutions in human cell lines. Our results showed that laser ablation allows the obtaining of stable and monodisperse Au-NPs in water, polyethylene glycol, and dextran solutions. The three types of Au-NPs were internalized in human cell lines, as shown by transmission electron microscopy. Biocompatibility and safety of Au-NPs were demonstrated by analyzing cell survival and cell morphology. Furthermore, incubation of the three Au-NPs in serum-containing culture medium modified their physicochemical characteristics, such as the size and the charge. The composition of the protein corona adsorbed on Au-NPs was investigated by mass spectrometry. Regarding composition of complement C3 proteins and apolipoproteins, Au-NPs prepared in dextran solution appeared as a promising drug carrier. Altogether, our results revealed the safety of laser-ablated Au-NPs in human cell lines and support their use for theranostic applications. Keywords: protein

  16. Estimation of the activity and doses to personnel which intake Iodine 131 by coffee consumption in a cabinet of Nuclear Medicine; Estimacion de la actividad y dosis a personal que ingirio Yodo 131 por consumo de cafe en un gabinete de Medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz C, M.A.; Alfaro L, M.; Salinas, J.A.; Molina, G. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    Soon after an incident in a cabinet of nuclear medicine, its were carried out in the National Institute of Nuclear Research of Mexico (ININ), a series of bio essays measurements by whole-body counting to six people attributed to this cabinet. Of six people, five are classified as Occupational Exposed Personnel (POE), and the other one that works as secretary, according to the General Regulation of Radiological Safety, is classified as public member. Six people that were involved in this incident, the one which presumably it took place among November 15 and 18, 2002 and that it consisted on the effusion of a vial containing an unknown quantity of Iodine-131 to a coffeepot, they ingested coffee in diverse quantities. The Iodine-131 is used in nuclear medicine, so much for the illnesses diagnostic like in the treatment of thyroid cancer and of hyperthyroidism. (Author)

  17. Efficacy of Two Cleaning Solutions for the Decontamination of 10 Antineoplastic Agents in the Biosafety Cabinets of a Hospital Pharmacy.

    Science.gov (United States)

    Anastasi, Marco; Rudaz, Serge; Queruau Lamerie, Thomas; Odou, Pascal; Bonnabry, Pascal; Fleury-Souverain, Sandrine

    2015-08-01

    This study aimed to evaluate two cleaning solutions for the chemical decontamination of antineoplastic agents on the surfaces of two biosafety cabinets routinely used for chemotherapy preparation in a hospital pharmacy. For almost 1 year (49 weeks), two different solutions were used for the weekly cleaning of two biosafety cabinets in a hospital pharmacy's centralized cytotoxic preparation unit. The solutions evaluated were a commercial solution of isopropyl alcohol (IPA) and water (70:30, vol:vol), and a detergent solution constituted by 10(-2)M of sodium dodecyl sulfate (SDS) with 20% IPA. Seven areas in each biosafety cabinet were wiped 14 times throughout the year, before and after the weekly cleaning process, according to a validated procedure. Samples were analyzed using a validated method of high-performance liquid chromatography coupled to mass spectrometry. The decontamination efficacy of these two solutions was tested for 10 antineoplastic agents: cytarabine, gemcitabine, methotrexate, etoposide phosphate, irinotecan, cyclophosphamide, ifosfamide, doxorubicin, epirubicin, and vincristine. Overall decontamination efficacies observed were 82±6% and 49±11% for SDS solution and IPA, respectively. Higher contamination levels were distributed on areas frequently touched by the pharmacy technicians-such as sleeves and airlock handles-than on scale plates, gravimetric control hardware, and work benches. Detected contaminations of cyclophosphamide, ifosfamide, gemcitabine, and cytarabine were higher than those of the others agents. SDS solution was almost 20% more efficient than IPA on eight of the antineoplastic agents. Both cleaning solutions were able to reduce contamination levels in the biosafety cabinets. The efficacy of the solution containing an anionic detergent agent (SDS) was shown to be generally higher than that of IPA and, after the SDS cleaning procedure, biosafety cabinets demonstrated acceptable contamination levels. © The Author 2015

  18. Biologics in the management of ulcerative colitis – comparative safety and efficacy of TNF-α antagonists

    Directory of Open Access Journals (Sweden)

    Fausel R

    2015-01-01

    Full Text Available Rebecca Fausel,1 Anita Afzali1,2 1Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, USA; 2Inflammatory Bowel Disease Program, UW Medicine – Harborview Medical Center, Seattle, WA, USA Abstract: Ulcerative colitis can cause debilitating symptoms and complications such as colonic strictures, colonic dysplasia, colorectal cancer, and toxic megacolon or perforation. Goals of treatment in ulcerative colitis include resolution of gastrointestinal symptoms, healing of colonic mucosa, and prevention of disease complications. Our treatment armamentarium has expanded dramatically over the past 10 years, and we now have multiple biologic agents approved for the treatment of moderate-severe disease, in addition to conventional therapies such as 5-aminosalicylates, thiopurines, and corticosteroids. In this review, we will provide a detailed discussion of the three tumor necrosis factor-alpha (TNF-α inhibitors currently approved for treatment of ulcerative colitis: infliximab, adalimumab, and golimumab. All three agents are effective for inducing and maintaining clinical response and remission in patients with ulcerative colitis, and they have comparable safety profiles. There are no head-to-head trials comparing their efficacy, and the choice of agent is most often based on insurance coverage, route of administration, and patient preference. Combination therapy with an immunomodulator is proven to be more effective than anti-TNF monotherapy, and patients who lose response to an anti-TNF agent should undergo dose intensification in order to regain clinical response. Despite therapeutic optimization, a significant percentage of patients will not achieve clinical remission with anti-TNF agents, and so newer therapies are on the horizon. Keywords: ulcerative colitis, inflammatory bowel disease, infliximab, adalimumab, golimumab

  19. Impact of automated dispensing cabinets on medication selection and preparation error rates in an emergency department: a prospective and direct observational before-and-after study.

    Science.gov (United States)

    Fanning, Laura; Jones, Nick; Manias, Elizabeth

    2016-04-01

    The implementation of automated dispensing cabinets (ADCs) in healthcare facilities appears to be increasing, in particular within Australian hospital emergency departments (EDs). While the investment in ADCs is on the increase, no studies have specifically investigated the impacts of ADCs on medication selection and preparation error rates in EDs. Our aim was to assess the impact of ADCs on medication selection and preparation error rates in an ED of a tertiary teaching hospital. Pre intervention and post intervention study involving direct observations of nurses completing medication selection and preparation activities before and after the implementation of ADCs in the original and new emergency departments within a 377-bed tertiary teaching hospital in Australia. Medication selection and preparation error rates were calculated and compared between these two periods. Secondary end points included the impact on medication error type and severity. A total of 2087 medication selection and preparations were observed among 808 patients pre and post intervention. Implementation of ADCs in the new ED resulted in a 64.7% (1.96% versus 0.69%, respectively, P = 0.017) reduction in medication selection and preparation errors. All medication error types were reduced in the post intervention study period. There was an insignificant impact on medication error severity as all errors detected were categorised as minor. The implementation of ADCs could reduce medication selection and preparation errors and improve medication safety in an ED setting. © 2015 John Wiley & Sons, Ltd.

  20. Commissioning a Narrowband (TL-01) Ultraviolet B Phototherapy Cabinet (Without getting your Fingers ... or Anything Else Burnt{exclamation_point})

    Energy Technology Data Exchange (ETDEWEB)

    Hince, A.J.; Colley, P.A.; Twitchen, L.; Lowe, A

    2000-07-01

    The recent introduction of narrowband UVB (TL01) phototherapy into the Dermatology Department of a general hospital is described. The initial treatment regime was modelled on that of an established centre. It is important to establish an appropriate starting dose for each patient to avoid either overdosage (resulting in painful erythema) or underdosage (slower patient throughput). Measurement of the minimum erythemal dose (MED) within the cabinet proved problematic and a separate testing device was built. The Waldmann cabinet was factory calibrated and did not appear to match a UK traceable standard (60% difference). This made it difficult to transfer dose levels between centres and between the treatment unit and the MED testing device. The treatment regime adopted has erred on the side of caution. Although this approach has been prudent it could have been improved by having UK standard treatment regimes, and consensus over dosimetry standards. (author)

  1. Calibration of an x-ray cabinet unit for radiobiology use

    International Nuclear Information System (INIS)

    McKerracher, Carolyn; Thwaites, David I

    2006-01-01

    A Faxitron sealed x-ray cabinet, operated at 100 kV, was modified to irradiate monkey testicles, to a uniform, accurately calibrated dose, for work aimed at investigating spermatogenesis in children undergoing radiotherapy. An aluminium filter was added to increase the beam quality and a lead collimating system manufactured to reduce the beam size to between 1 and 4 cm diameter. Percentage depth doses and profiles were analysed and relative in-air outputs measured with a selection of small (0.2 cc, 0.015 cc) ion chambers. The absolute calibration of the unit was carried out in a 10 x 10 cm 2 beam with a 0.6 cc chamber. Backscatter factors were based on standard tables, but then modified according to experimental results with thermoluminescent dosimeters (TLD) in a phantom to account for reduced scatter in the irradiation situations. A suitable irradiation set-up was devised for the monkeys, to ensure accuracy of delivered dose to the target volume and minimize the dose to the surrounding healthy tissue. The homogeneity throughout the testes was calculated to be well within ±5%, using a parallel-opposed irradiation technique. The TLD measured doses to the testes on three monkeys were lower than the calculated doses by 3 to 6%. Following modifications to the standard percentage depth doses to account for changes in scatter conditions, these differences became ±3%. The uncertainties on both calculated and measured dose were estimated to be approximately ±3.2% at 1 SD

  2. Evaluation of a storage cabinet for heat-sensitive endoscopes in a clinical setting.

    Science.gov (United States)

    Grandval, P; Hautefeuille, G; Marchetti, B; Pineau, L; Laugier, R

    2013-05-01

    In most countries, endoscopes must be disinfected or fully reprocessed before the beginning of each session, even if they were cleaned and disinfected after their last use. Several storage cabinets for heat-sensitive endoscopes (SCHE) are commercially available. They are designed to maintain the microbiological quality of reprocessed endoscopes for a predefined period of time validated by the SCHE manufacturer. Use of an SCHE increases the acceptable storage time before it is necessary to re-disinfect the endoscope. To evaluate the efficacy of an SCHE (DSC8000, Soluscope, SAS Marseilles, France) in a clinical setting. The microbiological quality of endoscopes was assessed after 72 h of storage in an SCHE (Group I), and compared with the microbiological quality of endoscopes stored for 72 h in a clean, dry, dedicated cupboard without morning disinfection (Group II) and the microbiological quality of endoscopes stored for 72 h in a clean, dry, dedicated cupboard with morning disinfection (Group III). Forty-one endoscopes in each group were sampled for microbiological quality. Endoscope contamination levels were analysed according to guidelines published by the National Technical Committee on Nosocomial Infection in 2007. Use of an SCHE helps to maintain the microbiological quality of endoscopes, provided that staff members are well trained and all practices are framed by a proven quality assurance process. Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  3. a Cabinet Level Thermal Test Vehicle to Evaluate Hybrid Double-Sided Cooling Schemes

    Science.gov (United States)

    Nie, Qihong; Joshi, Yogendra

    Packaging of power semiconductor devices presents some of the greatest thermal design challenges due to the resulting high heat fluxes. Advanced cooling techniques are desired to help meet these demands for current and future devices. A hybrid double-sided approach combining micro-channel liquid cooling, thermoelectric cooling, and forced air convection is investigated via a test vehicle for the thermal management of electronic cabinets. A reduction of 74% in the chip junction temperature rise was achieved by using double-sided cooling, compared to single-sided air convection. Further reduction can be achieved by utilizing thermoelectric cooling (TEC). Additional reductions of 22.4% and 6.5% were achieved by utilizing TEC in single-sided air cooling and double-sided cooling, respectively. The effect of water flow rates through the air-to-liquid heat exchanger and the microchannel heat sink on the chip junction temperature rise was insignificant, compared to the effect of TEC, and cooling configuration.

  4. [Biological safety of the molluscicidal ingredient from Aspergillus fumigatus SL-30 isolated from rhizosphere of Phytolacca acinosa].

    Science.gov (United States)

    Guo, Dan-Zhao; Chen, Jun

    2012-12-30

    To study biological safety of the molluscicidal ingredient (MI, a kind of diketopiperazines) in the exocellular broth of Aspergillus fumigatus SL-30' which was isolated from the rhizosphere of Phytolacca acinosa. The MI was prepared in concentrations ranging from 0.01 to 0.60 mg/L, at the same time molluscicidal activity against Oncomelannia hupensis was tested by using immersion method, and the LC50 in the case of immersion time for 24, 48 and 72 h was calculated. Acute toxicity of the MI with concentration ranging from 0.5 to 4.0 mg/L on Brachydanio rerio, Macrobrachium nippoensis and Rana limnochris was performed by standard laboratory procedure, and mortality rate of the tested animals with treated time of 24, 48 and 72 h was recorded. Effect of the MI on Eisenia fetida was tested using natural soil procedure with the dose of 1 and 10 mg/kg, and the poisoning performance and mortality in the 7th day and 14th day were recorded. Inhibition of the MI at 10 mg/kg on respiration of soil microorganisms was determined by sealed alkaline direct absorption method, and the released amount of CO2 (mg/100 g) in the 2nd, 5th, 7th, 10th, 12th and 15th day was determined. Molluscicidal activity of the MI against Oncomelania hupensis was shown with LC50 0.101, 0.062, and 0.022 mg/L in 24, 48 and 72 h, respectively. Mortality rate of Brachydanio rerio, Macrobrachium nippoensis and Rana limnochris all increased with the increase of MI concentration, and the LC50 of each kind of tested animals was recorded as follows: 1.941, 1.755 and 1.219 mg/L for Brachydanio rerio, 3.170, 2.720 and 2.419 mg/L for Macrobrachium nippoensis, 2.109, 1.751 and 1288 mg/L for Rana limnochris in 24, 48 and 72 h, respectively. The LC50 of MI on Eisenia fetida was >10.0 mg/kg. The inhibition rate of MI was less than 50% with a concentration of 10 mg/kg in 15 days. The MI shows molluscicidal activity on Oncomelania hupensis with much lower toxicity on Brachydanio rerio, Macrobrachium nippoensis and Rana

  5. Effects of a direct refill program for automated dispensing cabinets on medication-refill errors.

    Science.gov (United States)

    Helmons, Pieter J; Dalton, Ashley J; Daniels, Charles E

    2012-10-01

    The effects of a direct refill program for automated dispensing cabinets (ADCs) on medication-refill errors were studied. This study was conducted in designated acute care areas of a 386-bed academic medical center. A wholesaler-to-ADC direct refill program, consisting of prepackaged delivery of medications and bar-code-assisted ADC refilling, was implemented in the inpatient pharmacy of the medical center in September 2009. Medication-refill errors in 26 ADCs from the general medicine units, the infant special care unit, the surgical and burn intensive care units, and intermediate units were assessed before and after the implementation of this program. Medication-refill errors were defined as an ADC pocket containing the wrong drug, wrong strength, or wrong dosage form. ADC refill errors decreased by 77%, from 62 errors per 6829 refilled pockets (0.91%) to 8 errors per 3855 refilled pockets (0.21%) (p error type detected before the intervention was the incorrect medication (wrong drug, wrong strength, or wrong dosage form) in the ADC pocket. Of the 54 incorrect medications found before the intervention, 38 (70%) were loaded in a multiple-drug drawer. After the implementation of the new refill process, 3 of the 5 incorrect medications were loaded in a multiple-drug drawer. There were 3 instances of expired medications before and only 1 expired medication after implementation of the program. A redesign of the ADC refill process using a wholesaler-to-ADC direct refill program that included delivery of prepackaged medication and bar-code-assisted refill significantly decreased the occurrence of ADC refill errors.

  6. Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania

    DEFF Research Database (Denmark)

    Massaga, J J; Lusingu, J P; Makunde, R

    2008-01-01

    -immune healthy adult male volunteers with and without malaria parasites. The objective was to collect data on biological and haematological safety, tolerability, and parasitological efficacy to serve as baseline in the evaluation of the effectiveness of AQ preventive intermittent treatment against malaria...... morbidity in infants. Volunteers were stratified according to parasitaemia status and randomly assigned 20 participants each arm to three days treatment with either AQ or chloroquine (CQ). The level of difference of selected haematological and hepatological values pre-and post-trial were marginal and within...

  7. Xenograft biologic mesh in parietal and general surgery: Technical assessment and review of clinical effectiveness and safety data.

    Science.gov (United States)

    Sainfort, A; Denis Hallouard, I; Hartmann, D; Aulagner, G; Francois, Y; Tiffet, O; Barabino, G; Nuiry, O; Armoiry, X

    2016-12-01

    To describe the main technical characteristics of biologic prostheses used for parietal reinforcement and to present the state of the art on their risk/benefit ratio. We conducted a technical analysis of manufacturer specifications of the biologic prostheses that are currently available in France accompanied by a literature review by selecting meta-analyses and systematic reviews, randomized controlled trials and publications of health technology rating agencies. Biological implants for parietal reinforcement are mainly intended for use in a contaminated environment where the use of synthetic prostheses is contra-indicated. We identified fourteen systematic reviews and meta-analyses and one randomized controlled trial. Six ongoing clinical trials were identified as well as two clinical trials that had been interrupted. In the current state of knowledge, there are no high-level evidence data on the therapeutic contribution of biologic prostheses that allow prioritization of the various biologic prostheses according to their characteristics or their different manufacturing processes. Pending the results of current randomized controlled trials to validate the indications and an eventual specific reimbursement, indications for the use of biologic parietal reinforcement prostheses seems to be limited to rare clinical situations and only after collegial discussion. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  8. Diffuse large B-cell lymphoma associated with the use of biologic and other investigational agents: the importance of long-term post-marketing safety surveillance.

    Science.gov (United States)

    Goddard, Allison; Borovicka, Judy H; West, Dennis P; Evens, Andrew M; Laumann, Anne

    2011-01-01

    This case report describes a patient who developed diffuse large B-cell lymphoma (DLBCL) after receiving courses of two investigational biologic agents and cyclosporine followed by more than four years of subcutaneous efalizumab for the treatment of extensive chronic plaque psoriasis. Three years later, the patient remains free of lymphoma and his psoriasis is well controlled with thrice-weekly narrow-band ultraviolet phototherapy. This case emphasizes the importance of continued long-term post-marketing safety surveillance and the early reporting of all possible serious side effects, including cancers, related to the use of any newly available product. In particular, surveillance should focus on the immunomodulating biologic agents in order to identify possible dangerous sequelae.

  9. A Carboniferous Cabinet of Wonders: an example of how the collaboration of art and Earth Sciences can inspire conservation

    Science.gov (United States)

    Grey, Melissa; Rogers, Janine

    2016-04-01

    The Joggins Fossil Cliffs (Nova Scotia, Canada) is a UNESCO World Heritage Site representing the Late Carboniferous time period (ca. 310-325 mya). The site was formative for Charles Lyell in constructing his geological principles. It is still the best place in the world to view fossils from the Carboniferous 'Coal Age', a time when much of the coal that we use today was formed. The Joggins Fossil Institute is a not-for-profit, charitable organization that co-manages the site with the Province of Nova Scotia. Its mission is to conduct research and educate the public about Earth Sciences through interpretation (e.g., exhibits and tours of the site) and a fossil collection. Fossils are the only direct evidence of how biodiversity has changed over deep time; they are the texts and artifacts that we 'read' in order to understand the development of the earth and that can help humans decipher the deeper histories that produced us. At the Joggins Fossil Institute we primarily present the scientific history of the Carboniferous Period through the use of fossils, but we are also interested in the cultural history of coal production and usage, which is an essential part of the region's economic history. However, this industry has also contributed to climate change and the emergence of a new geological age called the Anthropocene. We encourage our visitors to connect palaeontology and coal energy consumption, and ask them to consider how different values (economic and scientific) are attributed to both coal and fossils; such questions lead directly to discussions about conservation issues. The Joggins Fossil Institute has partnered with the Faculty of Arts at nearby Mount Allison University to create an exhibit that will interrogate these questions. The medium of display that we have chosen is the "cabinet of wonders" or "cabinet of curiosity," which has a rich tradition in western cultures going back to the Renaissance. A venerable intersection of art and science, the cabinet

  10. Real-Time Perceptual Simulation of Moving Sources: Application to the Leslie Cabinet and 3D Sound Immersion

    Directory of Open Access Journals (Sweden)

    T. Voinier

    2008-07-01

    Full Text Available Perception of moving sound sources obeys different brain processes from those mediating the localization of static sound events. In view of these specificities, a preprocessing model was designed, based on the main perceptual cues involved in the auditory perception of moving sound sources, such as the intensity, timbre, reverberation, and frequency shift processes. This model is the first step toward a more general moving sound source system, including a system of spatialization. Two applications of this model are presented: the simulation of a system involving rotating sources, the Leslie Cabinet and a 3D sound immersion installation based on the sonification of cosmic particles, the Cosmophone.

  11. Real-Time Perceptual Simulation of Moving Sources: Application to the Leslie Cabinet and 3D Sound Immersion

    Directory of Open Access Journals (Sweden)

    Kronland-Martinet R

    2008-01-01

    Full Text Available Perception of moving sound sources obeys different brain processes from those mediating the localization of static sound events. In view of these specificities, a preprocessing model was designed, based on the main perceptual cues involved in the auditory perception of moving sound sources, such as the intensity, timbre, reverberation, and frequency shift processes. This model is the first step toward a more general moving sound source system, including a system of spatialization. Two applications of this model are presented: the simulation of a system involving rotating sources, the Leslie Cabinet and a 3D sound immersion installation based on the sonification of cosmic particles, the Cosmophone.

  12. COMPUTER-AIDED DESIGN ELEMENTS OF PRECISION FARMING SYSTEMS BASED ON THE PRINCIPLES BIOLOGIZATION, RESOURCE AND ENVIRONMENTAL SAFETY

    Directory of Open Access Journals (Sweden)

    V. Lobkov

    2012-01-01

    Full Text Available Development of practical methods of computer-aided design elements of precision farming systems on the basis of biological function, resource and environmental security for the producers of different specialization, ownership and financial security is the actual direction of development of modern agricultural science. Proposed development, which may serve as a basic programming model, allowing for expanded reproduction of soil fertility through the use of new ways to maximize the amount of phytomass in the agricultural lands, increase soil biological activity and reduce the costs of manufacturing nitrogen on yield formation of crops.

  13. Comparison of long-term drug survival and safety of biologic agents in patients with psoriasis vulgaris

    DEFF Research Database (Denmark)

    Gniadecki, R; Bang, B; Bryld, L E

    2015-01-01

    BACKGROUND: Drug survival (time to drug discontinuation) has recently emerged as an important parameter reflecting the long-term therapeutic performance in a real-life setting. Biologic drug survival in psoriasis is mainly limited by a gradual loss of efficacy over time. Previous studies have been...

  14. Health and safety manual

    International Nuclear Information System (INIS)

    1980-02-01

    The manual consists of the following chapters: general policies and administration; the Environmental Health and Safety Department; the Medical Services Department: biological hazards; chemical safety; confined space entry; cryogenic safety; electrical safety; emergency plans; engineering and construction; evacuations, trenching, and shoring; fire safety; gases, flammable and compressed; guarding, mechanical; ladders and scaffolds, work surfaces; laser safety; materials handling and storage; noise; personal protective equipment; pressure safety; radiation safety, ionizing and non-ionizing; sanitation; seismic safety; training, environmental health and safety; tools, power and hand-operated; traffic and transportation; and warning signs and devices

  15. Analysis of Critical Characteristics for Safety Graded Personnel Computers in the KNICS Architecture

    International Nuclear Information System (INIS)

    Lee, Hyun Chul; Lee, Dong Young

    2009-01-01

    Critical characteristics analysis of a safety related item is to identify characteristics to be verified to replace an original item with the dedicated item. It is sure that the dedicated item meeting critical characteristics would perform its intended safety function instead of the specified item. KNICS project developed two safety systems: IDiPS RPS (Reactor Protection System) and IDiPS ESF-CCS (Engineered Safety Features-Component Control System). Two safety systems of IDiPS are equipped with personnel computers, so-called COMs (Cabinet Operator Modules), in their cabinets. The personnel computers, COMs, are responsible for safety system monitoring, testing, and maintaining. Even though two safety systems are safety critical system, the personnel computers of two systems, i.e. COMs, are not graded as safety-graded items. Regulation requirements are expected to be strengthened, and the functions of the personnel computer may be enhanced to include safety-related functions and safety functions, it would be necessary that the grade of the personnel computers is adjusted to a higher level, the safety grade. To try to upgrade a non safety system, i.e. COMs, to a safety system, its safety functions and requirements, i.e. critical characteristics, must be identified and verified. This paper describes the process of the identification of critical characteristics and the results of analysis

  16. Safety and preliminary evidence of biologic efficacy of a mammaglobin-a DNA vaccine in patients with stable metastatic breast cancer.

    Science.gov (United States)

    Tiriveedhi, Venkataswarup; Tucker, Natalia; Herndon, John; Li, Lijin; Sturmoski, Mark; Ellis, Matthew; Ma, Cynthia; Naughton, Michael; Lockhart, A Craig; Gao, Feng; Fleming, Timothy; Goedegebuure, Peter; Mohanakumar, Thalachallour; Gillanders, William E

    2014-12-01

    Mammaglobin-A (MAM-A) is overexpressed in 40% to 80% of primary breast cancers. We initiated a phase I clinical trial of a MAM-A DNA vaccine to evaluate its safety and biologic efficacy. Patients with breast cancer with stable metastatic disease were eligible for enrollment. Safety was monitored with clinical and laboratory assessments. The CD8 T-cell response was measured by ELISPOT, flow cytometry, and cytotoxicity assays. Progression-free survival (PFS) was described using the Kaplan-Meier product limit estimator. Fourteen subjects have been treated with the MAM-A DNA vaccine and no significant adverse events have been observed. Eight of 14 subjects were HLA-A2(+), and the CD8 T-cell response to vaccination was studied in detail. Flow cytometry demonstrated a significant increase in the frequency of MAM-A-specific CD8 T cells after vaccination (0.9% ± 0.5% vs. 3.8% ± 1.2%; P cells (41 ± 32 vs. 215 ± 67 spm; P cell responses, and preliminary evidence suggests improved PFS. Additional studies are required to define the potential of the MAM-A DNA vaccine for breast cancer prevention and/or therapy. ©2014 American Association for Cancer Research.

  17. Use of UV-C radiation to disinfect non-critical patient care items: a laboratory assessment of the Nanoclave Cabinet

    Science.gov (United States)

    2012-01-01

    Background The near-patient environment is often heavily contaminated, yet the decontamination of near-patient surfaces and equipment is often poor. The Nanoclave Cabinet produces large amounts of ultraviolet-C (UV-C) radiation (53 W/m2) and is designed to rapidly disinfect individual items of clinical equipment. Controlled laboratory studies were conducted to assess its ability to eradicate a range of potential pathogens including Clostridium difficile spores and Adenovirus from different types of surface. Methods Each test surface was inoculated with known levels of vegetative bacteria (106 cfu/cm2), C. difficile spores (102-106 cfu/cm2) or Adenovirus (109 viral genomes), placed in the Nanoclave Cabinet and exposed for up to 6 minutes to the UV-C light source. Survival of bacterial contaminants was determined via conventional cultivation techniques. Degradation of viral DNA was determined via PCR. Results were compared to the number of colonies or level of DNA recovered from non-exposed control surfaces. Experiments were repeated to incorporate organic soils and to compare the efficacy of the Nanoclave Cabinet to that of antimicrobial wipes. Results After exposing 8 common non-critical patient care items to two 30-second UV-C irradiation cycles, bacterial numbers on 40 of 51 target sites were consistently reduced to below detectable levels (≥ 4.7 log10 reduction). Bacterial load was reduced but still persisted on other sites. Objects that proved difficult to disinfect using the Nanoclave Cabinet (e.g. blood pressure cuff) were also difficult to disinfect using antimicrobial wipes. The efficacy of the Nanoclave Cabinet was not affected by the presence of organic soils. Clostridium difficile spores were more resistant to UV-C irradiation than vegetative bacteria. However, two 60-second irradiation cycles were sufficient to reduce the number of surface-associated spores from 103 cfu/cm2 to below detectable levels. A 3 log10 reduction in detectable Adenovirus DNA

  18. Use of UV-C radiation to disinfect non-critical patient care items: a laboratory assessment of the Nanoclave Cabinet

    Directory of Open Access Journals (Sweden)

    Moore Ginny

    2012-08-01

    Full Text Available Abstract Background The near-patient environment is often heavily contaminated, yet the decontamination of near-patient surfaces and equipment is often poor. The Nanoclave Cabinet produces large amounts of ultraviolet-C (UV-C radiation (53 W/m2 and is designed to rapidly disinfect individual items of clinical equipment. Controlled laboratory studies were conducted to assess its ability to eradicate a range of potential pathogens including Clostridium difficile spores and Adenovirus from different types of surface. Methods Each test surface was inoculated with known levels of vegetative bacteria (106 cfu/cm2, C. difficile spores (102-106 cfu/cm2 or Adenovirus (109 viral genomes, placed in the Nanoclave Cabinet and exposed for up to 6 minutes to the UV-C light source. Survival of bacterial contaminants was determined via conventional cultivation techniques. Degradation of viral DNA was determined via PCR. Results were compared to the number of colonies or level of DNA recovered from non-exposed control surfaces. Experiments were repeated to incorporate organic soils and to compare the efficacy of the Nanoclave Cabinet to that of antimicrobial wipes. Results After exposing 8 common non-critical patient care items to two 30-second UV-C irradiation cycles, bacterial numbers on 40 of 51 target sites were consistently reduced to below detectable levels (≥ 4.7 log10 reduction. Bacterial load was reduced but still persisted on other sites. Objects that proved difficult to disinfect using the Nanoclave Cabinet (e.g. blood pressure cuff were also difficult to disinfect using antimicrobial wipes. The efficacy of the Nanoclave Cabinet was not affected by the presence of organic soils. Clostridium difficile spores were more resistant to UV-C irradiation than vegetative bacteria. However, two 60-second irradiation cycles were sufficient to reduce the number of surface-associated spores from 103 cfu/cm2 to below detectable levels. A 3 log10 reduction in

  19. Fire safety

    International Nuclear Information System (INIS)

    Keski-Rahkonen, O.; Bjoerkman, J.; Hostikka, S.; Mangs, J.; Huhtanen, R.; Palmen, H.; Salminen, A.; Turtola, A.

    1998-01-01

    According to experience and probabilistic risk assessments, fires present a significant hazard in a nuclear power plant. Fires may be initial events for accidents or affect safety systems planned to prevent accidents and to mitigate their consequences. The project consists of theoretical work, experiments and simulations aiming to increase the fire safety at nuclear power plants. The project has four target areas: (1) to produce validated models for numerical simulation programmes, (2) to produce new information on the behavior of equipment in case of fire, (3) to study applicability of new active fire protecting systems in nuclear power plants, and (4) to obtain quantitative knowledge of ignitions induced by important electric devices in nuclear power plants. These topics have been solved mainly experimentally, but modelling at different level is used to interpret experimental data, and to allow easy generalisation and engineering use of the obtained data. Numerical fire simulation has concentrated in comparison of CFD modelling of room fires, and fire spreading on cables on experimental data. So far the success has been good to fair. A simple analytical and numerical model has been developed for fire effluents spreading beyond the room of origin in mechanically strongly ventilated compartments. For behaviour of equipment in fire several full scale and scaled down calorimetric experiments were carried out on electronic cabinets, as well as on horizontal and vertical cable trays. These were carried out to supply material for CFD numerical simulation code validation. Several analytical models were developed and validated against obtained experimental results to allow quick calculations for PSA estimates as well as inter- and extrapolations to slightly different objects. Response times of different commercial fire detectors were determined for different types of smoke, especially emanating from smoldering and flaming cables to facilitate selection of proper detector

  20. Traffic safety in the future

    OpenAIRE

    EKKEHARD, Brühning; OKAMURA, Kazuko; FLEURY, Dominique; BRILON, Werner; DINGES, David F.; ABE, Takashi

    2013-01-01

    This booklet is divided in 4 parts : Traffic Safety in Japan and Germany - Success, Deficiencies, Future Potentials. Research on the Territorial Approach to Safety. Reliability of Motorway Operation. Transportation Safety and Operator Sleepiness: Where Biology Needs Technology.

  1. Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005); Analisis de la situacion de la independencia fisica de los equipos y circuitos electricos de seguridad de C. N. Almaraz respecto a la R. G. 1.75 rev 3 (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Seijas Portela, S.

    2010-07-01

    Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

  2. Safety and immunogenicity of Onderstepoort Biological Products’ Rift Valley fever Clone 13 vaccine in sheep and goats under field conditions in Senegal

    Directory of Open Access Journals (Sweden)

    Modou M. Lo

    2015-05-01

    Full Text Available This blinded field safety study was conducted in Senegal to assess safety and immunogenicity of administration of the registered dose of Rift Valley fever virus (RVFV Clone 13 vaccine (Onderstepoort Biological Products to sheep and goats of West African breeds under natural conditions. A total of 267 small ruminants (220 sheep, 47 goats were included; half received RVFV Clone 13 vaccine at the recommended dose and half received the diluent (as placebo only. The study was performed on three commercial farms in the northern and eastern region of Senegal in accordance with veterinary good clinical practices. The animals were observed daily for 3 days after vaccination, and then weekly for 1 year. In both sheep and goats vaccinated against RVFV seroconversion rates above 70% were recorded. No seroconversion related to RVFV was observed in placebo-treated animals. No statistically significant differences were determined between placebo and vaccinated groups for mean rectal temperatures for the first 3 days after administration (p > 0.05. No abnormal clinical signs related to treatment were noted, and only one slight injection site reaction was observed in one vaccinated animal for 2 days after vaccination. Out of 176 births assessed over 1 year (93 from the vaccinated group, 83 from the placebo group, 9 were abnormal in the placebo group and 3 in the vaccinated group (p > 0.05. The frequency of adverse events was similar in the placebo and vaccinated groups. RVFV Clone 13 vaccine administered according to the manufacturer’s instructions was safe and well tolerated in West African breeds of sheep and goats, including animals of approximately 6 months of age and pregnant females, under field conditions in Senegal. Antibody levels persisted up to 1 year after vaccination.

  3. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).

    Science.gov (United States)

    Fernández-Ruiz, M; Meije, Y; Manuel, O; Akan, H; Carratalà, J; Aguado, J M; Delaloye, J

    2018-02-07

    The field of new biological agents is increasing exponentially over the past years, thus making prevention and management of associated infectious complications a challenge for nonspecialized clinicians. The present consensus document is an initiative of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) aimed at analysing, from an infectious diseases perspective, the safety of targeted and biological therapies. Computer-based Medline searches with MeSH terms pertaining to each agent or therapeutic family. The document is structured in sections according to the targeted site of action of each drug class: proinflammatory cytokines; interleukins, immunoglobulins and other soluble immune mediators; cell surface receptors and associated signaling pathways; intracellular signaling pathways; lymphoma and leukaemia cells surface antigens; and other targeted therapies. A common outline is followed for each agent: summary of mechanism of action, approved indications and common off-label uses; expected impact on the host's susceptibility to infection; available clinical evidence (i.e. pivotal clinical trials, postmarketing studies, case series and case reports); and suggested prevention and risk minimization strategies. The methodologic and practical difficulties of assessing the specific risk posed by a given agent are also discussed. This ESGICH consensus document constitutes not only a comprehensive overview of the molecular rationale and clinical experience on the risk of infection associated with approved targeted therapies but also an attempt to propose a series of recommendations with the purpose of guiding physicians from different disciplines into this emerging framework. Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  4. Hatchery Spray Cabinet Administration Does Not Damage Avian Coronavirus Infectious Bronchitis Virus Vaccine Based on Analysis by Electron Microscopy and Virus Titration.

    Science.gov (United States)

    Roh, Ha-Jung; Jordan, Brian J; Hilt, Deborah A; Ard, Mary B; Jackwood, Mark W

    2015-03-01

    studies in our laboratory showed that the Arkansas-Delmarva Poultry Industry (Ark-DPI) vaccine given to 1-day-old chickens by hatchery spray cabinet replicated poorly and failed to adequately protect broilers against homologous virus challenge, whereas the same vaccine given by eye-drop did replicate and the birds were protected following homologous virus challenge. To determine if mechanical damage following spray application plays a role in failure of the Ark-DPI vaccine, we examined the morphology of three Ark-DPI vaccines from different manufacturers using an electron microscope and included a Massachusetts (Mass) vaccine as control. One of the Ark-DPI vaccines (vaccine A) and the Mass vaccine had significantly (P hatchery spray cabinet, suggesting that some other factor is contributing to the failure of that vaccine when given by that method.

  5. DEVELOPING CIRCULAR ECONOMY FOR THE RETAIL REFRIGERATION INDUSTRY: HOW FINANCIAL INCENTIVES COULD INFLUENCE REMANUFACTURiNG OF REFRIGERATED DISPLAY CABINETS IN THE UK

    OpenAIRE

    Muranko, Z; Andrews, D; Chaer, I; Newton, E; Proudman, P; Longhurst, M

    2016-01-01

    This paper examines how influential financial incentives could be in achieving a Circular Economy, with particular reference to the retail refrigeration industry. It underlines the potential monetary benefits for consumers who purchase remanufactured retail refrigeration equipment and highlights the potential financial incentives, which could help the producers of Refrigerated Display Cabinets (RDCs) to remanufacture. The Circular Economy is an economic and industrial system where resources a...

  6. Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1986 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Bowles, Edward C.

    1987-02-01

    Estimated kokanee (Oncorhynchus nerka) abundance in Lake Pend Oreille was 4.3 million during September 1986. This estimate was similar to 1985 and indicates continued suppression of the kokanee population since initial decline in the late 1960s. Atypically high survival of wild fry resulted in similar fry recruitment in 1986 as 1985, whereas hatchery-reared fry contributed only 8% to total fry recruitment as a result of low post-release survival (3%). Fry released into the Clark Fork River from Cabinet Gorge Hatchery had very low survival during emigration to Lake Pend Oreille, resulting from poor flow conditions and potentially high predation. Fry survival during emigration was twice as high during nighttime flows of 16,000 cfs than 7,800 cfs. Emigration also was faster during higher flows. Several marks were tested to differentially mark fry release groups to help determine impacts of flow and other factors on fry survival. Survival of fry marked with tetracycline and fluorescent dye was high (>99%) during the 10-week study. In contrast, survival of fry marked with fluorescent grit marks ranged from 5 to 93%, depending on application pressure and distance from the fry. Retention was high (>96%) for tetracycline and grit marks during the study, whereas dye marks were discernible (100%) for only one week. 23 refs., 20 figs., 10 tabs.

  7. Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1990 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Paragamian, Vaughn L.

    1991-03-01

    Rehabilitation of kokanee Oncorhynchus nerka in Lake Pend Oreille met with some success in 1990, but unexpected results have raised new questions. Estimated kokanee abundance during late August of 1990 was about 6.9 million fish. This is a decline of 19% from 1989, a continued decrease since 1988. The decreased population was attributed to low stocking of hatchery fry (7.3 million), lower wild fry survival in 1990 (1.5%), and exceptionally poor survival of fish ages 3+ and 4+. Average survival of the older fish was only 11% in 1990 compared to 72% in prior years. Compensatory survival was noted for kokanee ages 1+ and 2+, with an average of 81% in 1990 compared to 44% in 1989. Hatchery fry comprised 47% of the total kokanee fry recruitment in 1990 (80% of fry biomass). This contribution ranked third behind 1988 and 1989 since hatchery supplementation began in the 1970s. Survival of hatchery fry was 20%, the second highest since this investigation began. Findings of 1990 indicate a more comprehensive approach to managing kokanee must take into account predator stockings and predator/prey interaction. An unexpected low adult escapement was responsible for an egg-take of only 5.6 million eggs in 1990, 58% of the previous year, which will limit experimental stocking in 1991. Modification of the fish ladder at the Cabinet Gorge Fish Hatchery to improve adult escapement is strongly recommended to increase egg-take. 27 refs., 28 figs., 6 tabs.

  8. A comparative study of the safety and efficacy effect of 5-fluorouracil or mitomycin C mounted biological delivery membranes in a rabbit model of glaucoma filtration surgery

    Directory of Open Access Journals (Sweden)

    Wu ZH

    2013-03-01

    Full Text Available Zhihong Wu,1 Shuning Li,2 Ningli Wang,2 Wanshun Liu,3 Wen Liu3 1General Hospital of Armed Police Forces, Beijing, People’s Republic of China; 2Beijing Tongren Eye Center, Capital Medical University, Beijing, People’s Republic of China 3Ocean University of China, Qingdao, People’s Republic of China Purpose: To investigate the potential usage of biological delivery membranes containing mitomycin C (MMC or 5-fluorouracil (5-FU in the construction of glaucoma-filtering blebs, and to evaluate their safety and efficacy. Methods: Chitosan was selected as the biological membrane carrier to prepare sustained-released membranes. Twelve micrograms of 5-FU or MMC was covalently conjugated onto the membranes by solvent volatilization. Rabbits underwent glaucoma filtration surgery and were randomly allocated into one of the four treatment regimens: glaucoma filtration operation with no implantation of chitosan membrane group (as control, drug-free chitosan membrane implantation group (blank/placebo group, membrane containing 5-FU treatment group (5-FU group, and membrane containing MMC treatment group (MMC group. Each group consisted of 12 rabbits. Intraocular pressure (IOP was measured and evaluated over a 28-day period follow-up preoperatively, then after surgery on days 1, 3, 5, 7, 14, 21, and 28 by Tono-Pen. The aqueous humor was analyzed in each experimental and control groups at days 4, 6, 8, 10, 12, 14, 16, and 20 after operation. Bleb survival and anterior segment were examined with a slit lamp microscope and photographed simultaneously. Two rabbits from each group were killed on day 28 and eight eye samples obtained for histopathological study. Corneas and lenses were examined by transmission and scanning electron microscopy. Results: Both 5-FU and MMC significantly prolonged bleb survival compared with control groups. The filtering bleb’s survival period was significantly more prolonged in the MMC and 5-FU groups (maintained 14 days than the

  9. THE EFFICACY AND SAFETY OF RITUXIMAB BIOSIMILAR (ACELLBIA® IN RHEUMATOID ARTHRITIS AS THE FIRST BIOLOGICAL AGENT: RESULTS OF PHASE III (ALTERRA CLINICAL TRIAL

    Directory of Open Access Journals (Sweden)

    E. L. Nasonov

    2017-01-01

    Full Text Available The Russian biotechnological company «BIOCAD» has designed a chimeric monoclonal antibody against CD20 (BCD-020, Acellbia® that is a biosimilar of rituximab (RTM; MabThera®, F. Hoffmann-La Roche Ltd., Switzerland. In recent years, there has been evidence that RTM can be used at lower doses than those given in the standard recommendations and instructions for the use of this drug. This serves as the basis for the BCD-020-4/ALTERRA (ALTErnative Rituximab regimen in Rheumatoid Arthritis trial, the objective of which was to investigate the efficiency and safety of using Acellbia® (at a dose of 600 mg twice at a 2-week interval as the first biological agent (BA for methotrexate (MTX-resistant active rheumatoid arthritis (RA. The investigation enrolled 159 patients aged 18 to 80 years with active RA. After 24 weeks 65.7 and 29.4% of patients achieved 20% improvement by the American College of Rheumatology (ACR criteria in the Acellbia® + MTX and placebo (PL + MTX groups, respectively (p<0.0001. The differences in the ACR20 response rate in the two groups were 36.3% (95% CI, 19.27–53.28%. There were significant differences between the groups in the ACR50 response rates: 28.4% and 5.9% (p=0.001 and in the ACR70 ones: 12.8% and only 2.0%, respectively (p=0.036. Analysis of all recorded adverse events (AE frequency showed no significant differences between the patients in the study and control groups and demonstrates its equivalence with that of RTM (MabThera®; all the AE were expectable. It is noted that antibodies to RTM with binding and neutralizing activities had no impact on the efficiency and safety of therapy.

  10. Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan.

    Science.gov (United States)

    Takeuchi, Tsutomu; Ishida, Kota; Shiraki, Katsuhisa; Yoshiyasu, Takashi

    2018-01-01

    Post-marketing surveillance (PMS) was conducted to assess the safety and effectiveness of tacrolimus (TAC) add-on therapy for patients with rheumatoid arthritis (RA) and an inadequate response to biological disease-modifying anti-rheumatic drugs (DMARDs). Patients with RA from 180 medical sites across Japan were registered centrally with an electronic investigation system. The observational period was 24 weeks from the first day of TAC administration concomitantly with biological DMARDs. Safety and effectiveness populations included 624 and 566 patients, respectively. Patients were predominantly female (81.1%), with a mean age of 61.9 years. Overall, 125 adverse drug reactions (ADRs) occurred in 94 patients (15.1%), and 15 serious ADRs occurred in 11 patients (1.8%). These incidences were lower compared with previously reported incidences after TAC treatment in PMS, and all of the observed ADRs were already known. A statistically significant improvement was observed in the primary effectiveness variable of Simplified Disease Activity Index after TAC treatment; 62.7% of patients achieved remission or low disease activity at week 24. TAC is well tolerated and effective when used as an add-on to biological DMARDs in Japanese patients with RA who do not achieve an adequate response to biological DMARDs in a real-world clinical setting.

  11. Development and application of digital safety system in NPPs

    International Nuclear Information System (INIS)

    Kwon, Keechoon; Kim, Changhwoi; Lee, Dongyoung

    2012-01-01

    This paper describes the development of digital safety system in NPPs based on safety- grade programmable logic controller (PLC) platform and its application to real NPP construction. The digital safety system consists of a reactor protection system and an engineered safety feature-component control system. The safety-grade PLC platform was developed so that it meets the requirements of the regulation. The PLC consists of various modules such as a power module, a processor module, communication modules, digital input/output modules, analog input/output modules, a LOCA bus extension module, and a high-speed pulse counter module. The reactor protection system is designed with a redundant 4-channel architecture, and every channel is implemented with the same architecture. A single channel consists of a redundant bi-stable processor, a redundant coincidence processor, an automatic test and interface processor, and a cabinet operator module. The engineered safety feature-component control system is designed with four redundant divisions, and implemented with the PLC platform. The principal components of an individual division are fault tolerant group controllers, loop controllers, a test and interface processor, a cabinet operator module and a control channel gateway. The topical report is submitted to the regulatory body, and got safety evaluation report from the regulatory body. Also, the developed system is tested in the integrated performance validation facility. It is decided that the digital safety system applied to Shin-Uljin unit 1 and 2 after a topical report approval and validation test. Design changes occur in the digital safety system that is applied to an actual nuclear power plant construction, and the PLC has also been upgraded

  12. Safety of Biologic and Nonbiologic Disease-modifying Antirheumatic Drug Therapy in Veterans with Rheumatoid Arthritis and Hepatitis C Virus Infection.

    Science.gov (United States)

    Burton, Mary Jane; Curtis, Jeffrey R; Yang, Shuo; Chen, Lang; Singh, Jasvinder A; Mikuls, Ted R; Winthrop, Kevin L; Baddley, John W

    2017-05-01

    To examine the effect of disease-modifying antirheumatic drug (DMARD) therapy on hepatotoxicity among patients with rheumatoid arthritis (RA) and hepatitis C virus (HCV) infection. We identified biologic and nonbiologic treatment episodes of patients with RA using the 1997-2011 national data from the US Veterans Health Administration. Eligible episodes had HCV infection (defined by detectable HCV RNA) and subsequently initiated a new biologic or nonbiologic DMARD. Cohort entry required a baseline alanine aminotransferase (ALT) biologic/DMARD therapy. The primary outcome of interest was hepatotoxicity, defined as ALT elevation ≥ 100 IU/l or increase in HCV RNA of 1 log or more, and was examined within the first year of biologic/DMARD use. Results were reported as the cumulative incidence of treatment episodes achieving predefined hepatotoxicity at 3, 6, and 12 months after biologic/DMARD initiation. RA patients with HCV (n = 748) were identified and contributed 1097 biologic/DMARD treatment episodes. Overall, ALT elevations were uncommon, with 37 (3.4%) hepatotoxicity events occurring within 12 months. Treatment episodes with biologic DMARD demonstrated more frequency of hepatotoxicity than did nonbiologic DMARD (4.8% vs 2.3%, p = 0.03). Among treatment episodes involving hepatotoxicity events, the majority occurred within 6 months of DMARD initiation (29/37, 78%). In US veterans with HCV and RA receiving biologic and nonbiologic DMARD, the frequency of hepatotoxicity (ALT ≥ 100 IU/l) was low, with a higher frequency observed in treatment episodes with current biologic use.

  13. Gabinetes de partido único y democracias presidenciales. Indagaciones a partir del caso argentino Single Party Cabinets and Presidential Democracies: insights from the Argentinean case

    Directory of Open Access Journals (Sweden)

    Marcelo CAMERLO

    2013-07-01

    Full Text Available El estudio de los gabinetes presidenciales se ha focalizado predominantemente en las formaciones de coalición, distinguiendo a los ministros en función de su afiliación partidaria particularmente en los momentos de instauración y terminación del gabinete. Este artículo desplaza el foco de análisis hacia los gabinetes de partido único para indagar las modalidades de selección de ministros en situaciones donde el soporte legislativo de coalición pierde relevancia. Se propone un modelo de análisis que incluye la observación de afiliaciones extrapartidarias, capacidades técnicas individuales y vínculos personales con el presidente, y se lo aplica al estudio del caso argentino. Los resultados sugieren que presidentes bien posicionados tienden a aplicar estrategias de distribución de ministerios más cerradas, con grados de institucionalidad que dependen de la organización partidaria del presidente y su estilo de liderazgo.The study of presidential cabinets has mainly focused on coalitional formations, distinguishing individual ministers in terms of their party affiliation particularly at cabinet instauration and termination. This article moves the focus to single-party cabinets to study minister appointment in situations where the legislative support is less relevant. A model of analysis that observes extra-partisan affiliations, individual technical skills and personal liaison with the president is proposed and exploratory applied to the Argentinean case. The results suggest that well positioned presidents tend to apply closer strategies of portfolio distribution, with levels of institutionalization that depends on the president’s party organization and the president’s style of leadership.

  14. Vincent PETITET (2007), Enchantement et domination : le management de la docilité dans les organisations, analyse d’un cabinet de conseil

    OpenAIRE

    Guyot, Brigitte

    2013-01-01

    Cet ouvrage s’inscrit dans une approche communicationnelle de l’organisation, en analysant tous les dispositifs qui concourent à normaliser les comportements relationnels des consultants d’un grand cabinet de conseil étatsunien (Merton) implanté dans le monde entier. Pour ce faire, l’auteur décortique les mécaniques discursives, comportementales, relationnelles et managériales qui forgent un cadre normatif qui ne dit pas son nom, mais dont la puissance irrigue toute l’entreprise. Il invite so...

  15. WOMEN IN EXECUTIVE POSITIONS. THE INFLUENCE OF INSTITUTIONAL FACTORS AND GENDER STEREOTYPES ON WOMEN’S REPRESENTATION IN THE PERUVIAN PRESIDENTIAL CABINET

    Directory of Open Access Journals (Sweden)

    Petra Poskočilová

    2015-06-01

    Full Text Available This research paper deals with the representation of women in executive positions in presidential systems, specifically in a presidential cabinet of Peru, where the representation of women was progressively growing from 11 per cent in 2001 to 50 per cent in 2014. The main purpose of the article is an exploration of the impact that other components of power, like the President and the Parliament, and gender stereoptypes can have on the appointment of women. In the conclusion, the paper reveals the impact of the legislative gender quota and related higher representation of women in parliament on the number of female ministers.

  16. Laboratory testing in management of patients with suspected Ebolavirus disease: infection control and safety.

    Science.gov (United States)

    Gilbert, G L

    2015-08-01

    If routine laboratory safety precautions are followed, the risk of laboratory-acquired infection from handling specimens from patients with Ebolavirus disease (EVD) is very low, especially in the early 'dry' stage of disease. In Australia, border screening to identify travellers returning from EVD-affected west African countries during the 2014-2015 outbreak has made it unlikely that specimens from patients with unrecognised EVD would be sent to a routine diagnostic laboratory. Australian public health and diagnostic laboratories associated with hospitals designated for the care of patients with EVD have developed stringent safety precautions for EVD diagnostic and other tests likely to be required for supportive care of the sickest (and most infectious) patients with EVD, including as wide a range of point-of-care tests as possible. However, it is important that the stringent requirements for packaging, transport and testing of specimens that might contain Ebolavirus--which is a tier 1 security sensitive biology agent--do not delay the diagnosis and appropriate management of other potentially serious but treatable infectious diseases, which are far more likely causes of a febrile illness in people returning from west Africa. If necessary, urgent haematology, biochemistry and microbiological tests can be performed safely, whilst awaiting the results of EVD tests, in a PC-2 laboratory with appropriate precautions including: use of recommended personal protective equipment (PPE) for laboratory staff; handling any unsealed specimens in a class 1 or II biosafety cabinet; using only centrifuges with sealed rotors; and safe disposal or decontamination of all used equipment and laboratory waste.

  17. Column: File Cabinet Forensics

    Directory of Open Access Journals (Sweden)

    Simson Garfinkel

    2011-12-01

    Full Text Available Researchers can spend their time reverse engineering, performing reverse analysis, or making substantive contributions to digital forensics science. Although work in all of these areas is important, it is the scientific breakthroughs that are the most critical for addressing the challenges that we face.Reverse Engineering is the traditional bread-and-butter of digital forensics research. Companies like Microsoft and Apple deliver computational artifacts (operating systems, applications and phones to the commercial market. These artifacts are bought and used by billions. Some have evil intent, and (if society is lucky, the computers end up in the hands of law enforcement. Unfortunately the original vendors rarely provide digital forensics tools that make their systems amenable to analysis by law enforcement. Hence the need for reverse engineering.(see PDF for full column

  18. Safety of Hydrogen Systems Installed in Outdoor Enclosures

    Energy Technology Data Exchange (ETDEWEB)

    Barilo, Nick F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-11-01

    The Hydrogen Safety Panel brings a broad cross-section of expertise from the industrial, government, and academic sectors to help advise the U.S. Department of Energy’s (DOE) Fuel Cell Technologies Office through its work in hydrogen safety, codes, and standards. The Panel’s initiatives in reviewing safety plans, conducting safety evaluations, identifying safety-related technical data gaps, and supporting safety knowledge tools and databases cover the gamut from research and development to demonstration and deployment. The Panel’s recent work has focused on the safe deployment of hydrogen and fuel cell systems in support of DOE efforts to accelerate fuel cell commercialization in early market applications: vehicle refueling, material handling equipment, backup power for warehouses and telecommunication sites, and portable power devices. This paper resulted from observations and considerations stemming from the Panel’s work on early market applications. This paper focuses on hydrogen system components that are installed in outdoor enclosures. These enclosures might alternatively be called “cabinets,” but for simplicity, they are all referred to as “enclosures” in this paper. These enclosures can provide a space where a flammable mixture of hydrogen and air might accumulate, creating the potential for a fire or explosion should an ignition occur. If the enclosure is large enough for a person to enter, and ventilation is inadequate, the hydrogen concentration could be high enough to asphyxiate a person who entered the space. Manufacturers, users, and government authorities rely on requirements described in codes to guide safe design and installation of such systems. Except for small enclosures used for hydrogen gas cylinders (gas cabinets), fuel cell power systems, and the enclosures that most people would describe as buildings, there are no hydrogen safety requirements for these enclosures, leaving gaps that must be addressed. This paper proposes that

  19. Focus on the studies in support of fire safety analysis. IRSN modelling approach for nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Espargilliere, Julien; Meyrand, Raphael; Vinot, Thierry [Institut de Radioprotection et de Surete Nucleaire (IRSN), Fontenay-aux-Roses (France)

    2015-12-15

    For a fire safety analysis, in order to comply with nuclear safety goals, a nuclear fuel facility operator has to define the elements important for safety to be maintained, even in the case of a fire. One of the key points of this fire analysis is the assessment of possible fire scenarios in the facility. This paper presents the IRSN method applied to a case study to assess fire scenarios which have the most harmful effects on safety targets. The layout consists in a central room (fire cell) containing three glove boxes with radioactive material and three electrical cabinets. This room is linked to two connecting compartments (the fire cell and these two compartments define the containment cell) and then to two corridors. Each room is equipped with a mechanical ventilation system, and a pressure cascade is established from the corridors to the central room. A fire scenario was studied with fire ignition occurring in an electrical cabinet. This scenario has a set of safety goals (prevention of fire cell and containment device failure, propagation of the fire). This case study was conducted with the IRSN code SYLVIA based on two zones modelling. Safety goals were associated with key parameters and performance criteria to be fulfilled. Modelling assumptions were defined in order to maximize physical effects of the fire. Sensitivity studies were also conducted on key parameters such as oxygen limitation, equivalent-fuel definition. Eventually, a critical analysis of the code models was carried out.

  20. Psoriasis : implications of biologics

    NARCIS (Netherlands)

    Lecluse, L.L.A.

    2010-01-01

    Since the end of 2004 several specific immunomodulating therapies: ‘biologic response modifiers’ or ‘biologics’ have been registered for moderate to severe psoriasis in Europe. This thesis is considering the implications of the introduction of the biologics for psoriasis patients, focusing on safety

  1. Efficacy and safety of non-pharmacological and non-biological pharmacological treatment: a systematic literature review informing the 2016 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis

    Science.gov (United States)

    Regel, Andrea; van der Heijde, Désirée; Braun, Jürgen; Landewé, Robert; Van den Bosch, Filip; Falzon, Louise; Ramiro, Sofia

    2017-01-01

    To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism (EULAR) recommendations for the management of axSpA. A systematic literature review (2009–2016) of all non-pharmacological treatments, non-biological drugs (except targeted synthetic disease-modifying antirheumatic drugs (DMARDs)) and surgical therapies was performed. Randomised controlled trials (RCTs) and clinical controlled trials were assessed for efficacy and safety, while observational studies with a comparator were assessed for safety. All relevant efficacy and safety outcomes were included. Study heterogeneity precluded data pooling. If possible, Cohen's effect size was calculated for non-pharmacological treatments. In total, 45 papers and 2 abstracts were included. Studies on non-pharmacological treatments were very heterogeneous but overall confirmed a benefit for regular exercises, with small improvements in disease activity, function and spinal mobility. New studies on non-steroidal anti-inflammatory drugs (NSAIDs) confirmed their efficacy and new safety signals were not found. NSAIDs used continuously compared with on-demand did not reduce the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) mean change over 2 years in patients with ankylosing spondylitis with normal C reactive protein (CRP; ≤5 mg/L) (1 ‘negative’ RCT (0.9 vs 0.8; p=0.62)), while for patients with high CRP, conflicting results were found (1 ‘positive’ RCT (0.2 vs 1.7; p=0.003), 1 ‘negative’ RCT (1.68 vs 0.96; p=0.28)). No new trials were found for conventional synthetic DMARDs (csDMARDs). Short-term high-dose systemic glucocorticoids showed limited efficacy. Regular exercises may improve several outcomes. Efficacy and safety of NSAIDs in axSpA are confirmed. Glucocorticoids are not proven to be effective in axSpA and new

  2. Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1991 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Paragamian, Vaughn L.

    1991-01-01

    water temperatures of July, and higher cladoceran densities compared to June. River release Lower survival of the early Clark Fork is attributed to the exceptionally high river flows (1,984 cm /s or 70,000 ft /s) and low density of zooplankton. Age of adult kokanee sampled at Sullivan Springs was 1% age 2, 46% age 3, and 53% age 4. The high proportion of age 3 kokanee resulted in lower average fecundity. Recovery of about 160 fin clipped kokanee at Sullivan Springs provided evidence of imprinting. About 0.4% of the marked kokanee released in 1988 returned to spawn at age 3. This failure of a spawning run to Clark Fork River and low (<0.000l%) returns to the Cabinet Gorge Hatchery is a major concern. Total fishing effort was 460,679 h (220%) or about 12 h/hectare. A sport fishery survey indicated anglers harvested 276,457 fish of which 227,140 were kokanee and 2,157 Gerrard rainbow trout Oncorhynchus mykiss (>610 mm) while an additional 14,800 rainbow trout Oncorhynchus mykiss were released. The harvest of kokanee is at 33% of the management goals, but the harvest of large Gerrard rainbow trout was the best in 15 years.

  3. Safety measures for the main control board replacement project at Ikata units 1 and 2

    International Nuclear Information System (INIS)

    Hashimoto, Nozomu; Tada, Kenji

    2013-01-01

    When Units 1 and 2 of the Ikata Power Station underwent replacement of their main control boards, control cabinets, and associated equipment, it was necessary to remove all the control boards, cabinets, and cables from the control building including from the main control room. This meant the loss of operation and monitoring functions in the main control room and functions of control cabinets. To maintain the operation and monitoring functions required under plant shutdown conditions, temporary operation and monitoring equipment (i.e., temporary main control board) was installed in the temporary main control room. The advance preparations included a trial switching from the permanent to the temporary main control board to identify and address potential problems in advance. When the replacement work was underway, a work schedule sheet posted in the temporary and the permanent control rooms was used to prevent human errors caused by operators’ recognition errors. Monitoring and control signals were switched from the old boards to the temporary boards and from the temporary boards to the new boards at appropriate timings to ensure plant safety during the replacement operation. (author)

  4. Field Application of the Micro Biological Survey Method for the Assessment of the Microbiological Safety of Different Water Sources in Horn of Africa and the Evaluation of the Effectiveness of Moringa Oleifera in Drinking Water Purification

    Science.gov (United States)

    Losito, Francesca; Arienzo, Alyexandra; Somma, Daniela; Murgia, Lorenza; Stalio, Ottavia; Zuppi, Paolo; Rossi, Elisabetta; Antonini, Giovanni

    2017-01-01

    Water monitoring requires expensive instrumentations and skilled technicians. In developing Countries as Africa, the severe economic restrictions and lack of technology make water safety monitoring approaches applied in developed Countries, still not sustainable. The need to develop new methods that are suitable, affordable, and sustainable in the African context is urgent. The simple, economic and rapid Micro Biological Survey (MBS) method does not require an equipped laboratory nor special instruments and skilled technicians, but it can be very useful for routine water analysis. The aim of this work was the application of the MBS method to evaluate the microbiological safety of different water sources and the effectiveness of different drinking water treatments in the Horn of Africa. The obtained results have proved that this method could be very helpful to monitor water safety before and after various purification treatments, with the aim to control waterborne diseases especially in developing Countries, whose population is the most exposed to these diseases. In addition, it has been proved that Moringa oleifera water treatment is ineffective in decreasing bacterial load of Eritrea water samples. PMID:28748063

  5. LE CONCEPT DE CONTROLE DE GESTION CREATIF ILLUSTRATION PAR UNE RECHERCHE-INTERVENTION DANS UN CABINET D'AUDIT ET DE CONSEIL

    OpenAIRE

    Djamel Khouatra; Laurent Cappelletti

    2001-01-01

    International audience; Cette communication présente le concept de contrôle de gestion créatif à partir d'une étude de cas consistant en une recherche-intervention conduite de 1999 à 2000 dans un cabinet d'audit et de conseil. L'hypothèse centrale est qu'il est possible de développer un contrôle de gestion qui soit un processus créatif permettant au contrôleur de remplir sa mission traditionnelle de réduction des coûts, mais également de contribuer au développement des activités et à l'accroi...

  6. [Research on mutual collation between Japan Cabinet Edition and National Beijing Library Edition of Shang han lun (Treatise on Cold Pathogenic Disease)].

    Science.gov (United States)

    Qian, Chao-Chen; Liang, Yong-Xuan

    2004-01-01

    Through textual research on the Song Dynasty block-printed large-character and small-character editions of Shang han lun (Treatise on Cold Pathogenic Disease), it can be definitely verified that Yang Shoujing's so-called 'facsimile handwritten copy of Northern Song edition' was an apocrypha fabricated by Yang himself. Japanese Horikawa's An zheng edition, the original edition adopted by Yun Tieqiao's photocopy, did exert a profound and lasting influence on China. After collating the Song Dynasty block-printed edition collected in Japan National Cabinet Library with the one collected in the National Beijing Library thoroughly, and checking the prefaces and postscripts carefully, it has been found, for the first time, that these two editions, both called 'Song edition', differ dramatically.

  7. Synthetic biology and occupational risk.

    Science.gov (United States)

    Howard, John; Murashov, Vladimir; Schulte, Paul

    2017-03-01

    Synthetic biology is an emerging interdisciplinary field of biotechnology that involves applying the principles of engineering and chemical design to biological systems. Biosafety professionals have done an excellent job in addressing research laboratory safety as synthetic biology and gene editing have emerged from the larger field of biotechnology. Despite these efforts, risks posed by synthetic biology are of increasing concern as research procedures scale up to industrial processes in the larger bioeconomy. A greater number and variety of workers will be exposed to commercial synthetic biology risks in the future, including risks to a variety of workers from the use of lentiviral vectors as gene transfer devices. There is a need to review and enhance current protection measures in the field of synthetic biology, whether in experimental laboratories where new advances are being researched, in health care settings where treatments using viral vectors as gene delivery systems are increasingly being used, or in the industrial bioeconomy. Enhanced worker protection measures should include increased injury and illness surveillance of the synthetic biology workforce; proactive risk assessment and management of synthetic biology products; research on the relative effectiveness of extrinsic and intrinsic biocontainment methods; specific safety guidance for synthetic biology industrial processes; determination of appropriate medical mitigation measures for lentiviral vector exposure incidents; and greater awareness and involvement in synthetic biology safety by the general occupational safety and health community as well as by government occupational safety and health research and regulatory agencies.

  8. Natural infection of cattle with an atypical 'HoBi'-like pestivirus--implications for BVD control and for the safety of biological products.

    Science.gov (United States)

    Ståhl, Karl; Kampa, Jaruwan; Alenius, Stefan; Persson Wadman, Annie; Baule, Claudia; Aiumlamai, Suneerat; Belák, Sándor

    2007-01-01

    During a study on Bovine Viral Diarrhoea (BVD) epidemiology in Thailand, a pestivirus was detected in serum from a calf. Comparative nucleotide sequence analysis showed that this virus was closely related to a recently described atypical pestivirus (D32/00_'HoBi') that was first isolated from a batch of foetal calf serum collected in Brazil. The results from virus neutralisation tests performed on sera collected from cattle in the herd of the infected calf, showed that these cattle had markedly higher antibody titres against the atypical pestivirus 'HoBi' than against Bovine Viral Diarrhoea Virus types 1 and 2, or Border Disease Virus. The results also supported, consequently, the results from the molecular analysis, and demonstrated that a 'HoBi'-like pestivirus had been introduced to, and was now circulating in the herd. This study is the first to report a natural infection in cattle with a virus related to this atypical pestivirus, and it suggests that this group of pestiviruses may already be spread in cattle populations. The findings have implications for BVD control and for the biosafety of vaccines and other biological products produced with foetal calf serum. Consequently, these atypical pestiviruses should be included in serological assays, and any diagnostic assay aimed at detection of pestiviruses in biological products or animals should be tested for its ability to detect them.

  9. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma.

    Science.gov (United States)

    Busse, William W; Katial, Rohit; Gossage, David; Sari, Suha; Wang, Bing; Kolbeck, Roland; Coyle, Anthony J; Koike, Masamichi; Spitalny, George L; Kiener, Peter A; Geba, Gregory P; Molfino, Nestor A

    2010-06-01

    Increased eosinophil levels have been linked to airway inflammation and asthma exacerbations. IL-5 is responsible for eosinophil differentiation, proliferation, and activation; IL-5 receptors are expressed on eosinophils and their progenitors, and targeting such receptors induces eosinophil apoptosis. To evaluate the safety profile, pharmacokinetics, and pharmacodynamics of MEDI-563, a humanized mAb targeting the IL-5 receptor alpha chain. Single, escalating, intravenous doses (0.0003-3 mg/kg) of MEDI-563 were administered to subjects with mild atopic asthma (n = 44) over approximately 3 to 30 minutes in this open-label study. Pulmonary function, symptom scores, adverse events, MEDI-563 pharmacokinetics, and levels of C-reactive protein (CRP), IL-6, eosinophil cationic protein (ECP), and eosinophils were evaluated. Mean peripheral blood (PB) eosinophil levels decreased in a dose-dependent fashion (baseline +/- SD, 0.27 +/- 0.2 x 10(3)/microL; 24 hours postdose, 0.01 +/- 0.0 x 10(3)/microL); 94.0% of subjects receiving >or=0.03 mg/kg exhibited levels between 0.00 x 10(3)/microL and 0.01 x 10(3)/microL. Eosinopenia lasted at least 8 or 12 weeks with doses of 0.03 to 0.1 and 0.3 to 3 mg/kg, respectively. ECP levels were reduced from 21.4 +/- 17.2 microg/L (baseline) to 10.3 +/- 7.0 microg/L (24 hours postdose). The most frequently reported adverse events were reduced white blood cell counts (34.1%), nasopharyngitis (27.3%), and increased blood creatine phosphokinase (25.0%). Mean C-reactive protein levels increased approximately 5.5-fold at 24 hours postdose but returned to baseline by study end; mean IL-6 levels increased approximately 3.9-fold to 4.7-fold at 6 to 12 hours postdose, respectively. Pharmacokinetic activity was dose proportional at doses of 0.03 to 3 mg/kg. Single escalating doses of MEDI-563 had an acceptable safety profile and resulted in marked reduction of PB eosinophil counts within 24 hours after dosing. Copyright (c) 2010 American Academy of

  10. 21 CFR 610.11 - General safety.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false General safety. 610.11 Section 610.11 Food and... GENERAL BIOLOGICAL PRODUCTS STANDARDS General Provisions § 610.11 General safety. A general safety test... for administration to humans. The general safety test is required in addition to other specific tests...

  11. Spectroradiometry in industrial safety

    Science.gov (United States)

    Ott, Guenter; Schreiber, Paul

    1986-10-01

    Aspects of industrial safety related to the use and the production of artificial radiation sources are treated with emphasis on UV radiation. Application of artificial radiation sources, whereby the radiation is used in the working process or is present as a perturbation, are outlined. Biological action functions and radiation thresholds for industrial safety are discussed. Spectral and integral measuring methods and apparatus are presented. Examples of measurements performed at workplaces exposed to radiation are given.

  12. RAF/9/049: Enhancing and Sustaining the National Regulatory Bodies for safety

    International Nuclear Information System (INIS)

    Keter, C.J.

    2017-01-01

    The main objective of this project is to enhance regulatory infrastructure, sustainability and cooperation among national regulatory bodies. This will support strengthening of the existing regulatory framework and capacity building in the region. Self-Assessment using the Self-Assessment Regulatory Infrastructure for Safety (SARIS) was completed on 26th May 2016. Changes made to the legislation is ongoing. The Nuclear Regulatory Bill 2017 is at an advanced stage and about to be tabled to Cabinet. The project objectives shall be addressed under a new project, RAF/9/058 – Improving the Regulatory Framework for the Control of Radiation Sources in Member States. Two major tasks for Kenya to focus include Review of regulations on waste safety, radiation sources and on safety of NPP and advising on drafting of radiation safety guides

  13. Equipment line-up developed for structuring programmed digital systems important to safety

    International Nuclear Information System (INIS)

    Remus, L.; Colling, J.M.; Buisson, J.

    1984-11-01

    The use of the programmed digital techniques in systems important to safety led to developing equipment line-ups which allow to procedure, through using a restricted number of sub-assemblies, a variety of facilities capable of performing diversified functions. Upon remembering the requirements that such equipments are required to meet, the equipments produced by Merlin Gerin are described in this paper. Such equipments include a whole set of printed circuit boards, plug-in units with self-engaging connectors and the related cabinets to accommodate them. The following systems are made up of such equipments: digital integrated protection system, rod control and monitoring system, reactor power distribution monitoring equipment [fr

  14. A development and biological safety evaluation of novel PVC medical devices with surface structures modified by UV irradiation to suppress plasticizer migration.

    Science.gov (United States)

    Haishima, Yuji; Isama, Kazuo; Hasegawa, Chie; Yuba, Toshiyasu; Matsuoka, Atsuko

    2013-09-01

    This study examines the chemical, physicochemical, and biological properties of PVC sheets treated with UV irradiation on their surfaces to suppress the elution of a plasticizer, di-(2-ethylhexyl) phthalate (DEHP), for developing novel polyvinyl chloride (PVC) medical devices. The PVC sheets irradiated under conditions 1 (52.5 μW/cm(2), 136 J/cm(2)) and 2 (0.45 mW/cm(2), 972 J/cm(2)) exhibited considerable toxicity in cytotoxicity tests and chromosome aberration tests due to the generation of DEHP oxidants, but no toxicity was detected in the PVC sheet irradiated under condition 3 (8.3 mW/cm(2), 134 J/cm(2)). The release of DEHP from the surface irradiated under condition 3 was significantly suppressed, and mono-(2-ethylhexyl) phthalate (MEHP) converted from a portion of DEHP could be easily removed from the surface by washing with methanol. The physicochemical properties of the surface regarding the suppression of DEHP elution remained stable through all sterilizations tested, but MEHP elution was partially recrudesced by the sterilizations except for gamma irradiation. These results indicated that UV irradiation using a strong UV-source over a short time (condition 3) followed by methanol washing and gamma sterilization may be useful for preparing novel PVC products that did not elute plasticizers and do not exhibit toxicity originating from UV irradiation. Copyright © 2013 Wiley Periodicals, Inc.

  15. Nuclear safety

    International Nuclear Information System (INIS)

    1991-02-01

    This book reviews the accomplishments, operations, and problems faced by the defense Nuclear Facilities Safety Board. Specifically, it discusses the recommendations that the Safety Board made to improve safety and health conditions at the Department of Energy's defense nuclear facilities, problems the Safety Board has encountered in hiring technical staff, and management problems that could affect the Safety Board's independence and credibility

  16. Comprehensive Biological Monitoring to Assess Isocyanates and Solvents Exposure in the NSW Australia Motor Vehicle Repair Industry.

    Science.gov (United States)

    Hu, Jimmy; Cantrell, Phillip; Nand, Aklesh

    2017-10-01

    Urethane products that contain isocyanates are extensively used in the motor vehicle repair (MVR) industry and other industries such as furniture and cabinet-making as two-pack spray paints, clears, and adhesives. Attention has recently been refocussed on isocyanate-containing chemicals, particularly in paints. The spray painters in the MVR industry had a propensity to develop industrial asthma at a rate 80 times higher than the general public, which was previously reported in the UK. To track workers exposure to isocyanates, urine samples were collected from 196 spray painters who worked mainly in 78 MVR shops across 54 New South Wales (NSW) towns and suburbs. The biological monitoring also covered exposure testing to a wide variety of solvents including aromatic hydrocarbons, ketones, and alcohols. The main finding of the study was that 2.6% of the spray painters surveyed in the MVR industry in NSW that handled isocyanate-containing paints showed exposure to isocyanates; with 1.0% being moderately exposed, which is more than twice the current UK's Health and Safety Executive (HSE) Biological Monitoring Guidance Value (BMGV) of 1 µmol mol-1 creatinine. Potential exposures to toluene (a solvent often found in paint thinners) was monitored via hippuric acid (HA) urine levels and showed 2.6% of the spray painters surveyed to be over the US' American Conference of Government Industrial Hygienists (ACGIH) Biological Exposure Index (BEI) of 1010 mmol/mole creatinine for HA. The other solvents or their metabolites were all below their respective BEI; these comprised benzene, xylene, ethyl benzene, methyl ethyl ketone, acetone, methanol, and ethanol. These findings indicate that isocyanates and certain solvents exposure were occurring in the NSW Australia vehicle repair industry, albeit at lower levels than previous occupational biological monitoring studies that showed higher exposure levels, particularly for isocyanates. One reason for this could be the increasing use

  17. Complete Biological Evaluation of Therapeutical Radiopharmaceuticals in Rodents, Laboratory Beagles and Veterinary Patients - Preclinical Distribution-, Kinetic-, Excretion-, Internal Dosimetry-, Radiotoxicological-, Radiation Safety- and Efficacy Data

    International Nuclear Information System (INIS)

    Balogh, L.; Domokos, M.; Polyak, A.; Thuroczy, J.; Janoki, G.

    2009-01-01

    The research and development of various novel therapeutical radiopharmaceuticals is a huge demand in many laboratories world-wide. Beside of multiple bone metastases pain-palliation and radiosynovectomy agents a number of specific radiopharmaceutical applicants mainly for oncological applications are in the pipeline. Numerous in vitro methods are available in the first line to test the radiolabelling efficiency, the possible radioactive and non-labelled impurities, the stability of the label at different conditions and mediums, and some specific characteristics of radiopharmaceutical applicants eg.: receptor binding assays, antigen-antibody assays. But, still before human clinical trials there are several questions to be solved in regards of toxicology, radiotoxicology, radiation safety and maybe most importantly the efficacy tasks. All these issues cannot be answered without animal tests. Several decades back animal tests in radiopharmacy meant only standard bioassays in a large number of healthy rodents. Later on pathological models eg.: human tumor xenografts in immunodeficient animals came-out and through them radiopharmaceutical tumor-uptake by the targets were available to evaluate in vivo as well. Xenografts are still popular and widely used models in the field but instead of wide-scaled bioassays nowadays repeated scintiscans or hybrid images (SPECT/CT, PET/CT) are more and more often used to answer kinetic-, excretion-, tumor uptake, internal dosimetry (Minimum Effective Dose, Maximum Tolerable Dose, critical organ doses, tumor doses) questions. Greater animals like laboratory Beagles are more closely in size, clinical and metabolic parameters to the human objects so playing a more perfect role of human medical doctor and especially veterinary patients. Easy to understand that many of the spontaneously occurring companion animal diseases are a good model of human pathological diseases. The need of a better diagnosis and treatment of that animals meets with

  18. Nuclear safety

    International Nuclear Information System (INIS)

    Tarride, Bruno

    2015-10-01

    The author proposes an overview of methods and concepts used in the nuclear industry, at the design level as well as at the exploitation level, to ensure an acceptable safety level, notably in the case of nuclear reactors. He first addresses the general objectives of nuclear safety and the notion of acceptable risk: definition and organisation of nuclear safety (relationships between safety authorities and operators), notion of acceptable risk, deterministic safety approach and main safety principles (safety functions and confinement barriers, concept of defence in depth). Then, the author addresses the safety approach at the design level: studies of operational situations, studies of internal and external aggressions, safety report, design principles for important-for-safety systems (failure criterion, redundancy, failure prevention, safety classification). The next part addresses safety during exploitation and general exploitation rules: definition of the operation domain and of its limits, periodic controls and tests, management in case of incidents, accidents or aggressions

  19. Drug Safety

    Science.gov (United States)

    ... over-the-counter drug. The FDA evaluates the safety of a drug by looking at Side effects ... clinical trials The FDA also monitors a drug's safety after approval. For you, drug safety means buying ...

  20. Concurrence, coopération et flux de conseil dans un cabinet américain d'avocats d'affaires : les échanges d' idées entre collègues

    OpenAIRE

    Lazega, Emmanuel

    1995-01-01

    Cet article étudie les relations de conseil dans un cabinet américain d'avocats d'affaires. On y montre l'existence de normes régulant l'échange de cette ressource, normes étroitement liées à la structure formelle du cabinet. Une analyse du réseau constitué par ces relations permet de dégager la structure sociale ou informelle de ce système d'échange. Cette dernière montre que les acteurs en concurrence dans ce système (pour des ressources comme la main-d'oeuvre, les clients, le prestige, le ...

  1. Le positionnement stratégique des acteurs dans la prise en compte des risques psychosociaux au travail. Le cas des cabinets-conseil spécialisés en prévention des RPS

    OpenAIRE

    Tarik Chakor

    2012-01-01

    Ce document a été rédigé à l'occasion d'un séminaire de thèse se déroulant le 4/6/12 au LEST-CNRS (UMR 7317, Aix-en-Provence). Son objectif est de présenter un état d'avancement sur la réflexion autour du rôle des cabinets-conseil dans la prévention des RPS. L'analyse des RPS comme un phénomène potentiellement conflictuel et stratégique, notamment à partir de la multiplicité des approches disciplinaires, permet de mettre en évidence différents positionnements stratégiques des cabinets, du cab...

  2. Use of biological indexes of the common reed (Phragmites australis) seed progeny in the environmental safety of radioactive contaminated water bodies

    Energy Technology Data Exchange (ETDEWEB)

    Yavnyuk, A. [National Aviation University, Kiev (Ukraine); Shevtsova, N.; Gudkov, D. [Institute of Hydrobiology of the National Academy of Sciences, Kiev (Ukraine)

    2014-07-01

    effects were investigated via following indexes - occurrence of abnormality of certain type (geotropism and ontogenesis disturbance, chlorophyll abnormalities and root necrosis) in relation to the whole investigated sampling and occurrence of plants, progeny of which has detached abnormal forms. Our studies resulted in dose dependent character of the majority of investigated indexes. The most radiosensitive indexes of the common reed in conditions of long-term low-dose irradiation of parent plants include: all vitality indexes, frequency distribution of root and leaf length of germs, in progeny of which abnormal forms are detached. No reliable correlation was determined for dose dependences of root length distribution and abnormalities of particular type. Significant differences of studied indexes of seeds, with absorbed dose rate of parent plants 0.7-22.0 mcGy h{sup -1}, were determined in conditions of long-term ionizing radiation within the Chernobyl Exclusion Zone. It is assumed that hormesis effect on littoral zone vegetation within the Chernobyl Exclusion Zone does exist. Studied indexes may be recommended for use in the complex determination of water bodies' radioecological safety. Document available in abstract form only. (authors)

  3. Improving the reliability of Class 1E power distribution to instrumentation and control cabinets on nuclear power plants in the USA. Final report

    International Nuclear Information System (INIS)

    Brennen, M.B.

    1995-09-01

    This study was conducted to explore nontraditional electric power distribution concepts to improve the reliability of uninterruptible power to vital Instrumentation and Control (I and C) cabinets in future US nuclear power plants. The study incorporated comparative technical and economic evaluations of existing and nontraditional uninterruptible power supply (UPS) concepts. All nontraditional distribution concepts were based on available or already emerging components or semiconductor devices. Another purpose of the study was to reduce the cost and complexity of present power distribution and to lower maintenance, replacement, degradation and fault location requirements. The possible reduction of distribution losses, especially during operation under battery power, was also evaluated. The study indicates that direct current distribution at 48 or 125 Vdc levels would have more than an order of magnitude improvement over the reliability of present alternating current supplies at comparable cost. Furthermore, losses under battery power could be reduced significantly with respect to present distribution losses. An inherent advantage of DC distribution is that power transfer from the failed power bus to an operational bus occurs naturally and instantaneously via two simple and reliable semiconductor diodes. AC distribution, on the other hand, requires complex synchronization, decision making and gated semiconductor switching devices for power bus transfer all of which could be eliminated. Some of the concepts presented may also be applied to make existing vital (Class 1E) uninterruptible power supplies in US nuclear plants more reliable

  4. [Safety and electromagnetic compatibility in sanitary field].

    Science.gov (United States)

    Bini, M; Feroldi, P; Ferri, C; Ignesti, A; Olmi, R; Priori, S; Riminesi, C; Tobia, L

    2012-01-01

    In sanitary field and especially in a hospital, multiple sources of non ionizing radiation are used for diagnostic and therapeutic aims. In sanitary sector both workers and users are present at the same time, and in some cases general population could need higher protection than workers in relationship to the exposition to electromagnetic fields. In order to protect health and safety of patients, general population and workers of hospitals and with the aim to identify, analyze, evaluate and study its level of significance, electrical, magnetic and electromagnetic sources Research Italian project Si.C.E.O. (Safety And Electromagnetic Compatibility In Sanitary Field) was instituted. Target of our research project was to deepen risk of exposition elements with analysis of outdoor (e.g. power lines, transmission cabinets) and indoor (e.g. equipment for physical therapy) sources, located in sanitary structures and to verify the level exposition of workers and common population end the respect of specific regulation, and finally to define technical and organizational measures really useful for protection and reduction of risk.

  5. Systems Biology

    Indian Academy of Sciences (India)

    IAS Admin

    Systems biology seeks to study biological systems as a whole, contrary to the reductionist approach that has dominated biology. Such a view of biological systems emanating from strong foundations of molecular level understanding of the individual components in terms of their form, function and interactions is promising to ...

  6. Using Baby Books to Increase New Mothers’ Safety Practices

    Science.gov (United States)

    Reich, Stephanie M.; Penner, Emily K.; Duncan, Greg J.

    2010-01-01

    Objective To determine if educational baby books are an effective method for increasing low-income, first-time mothers’ safety practices during their child’s first 18 months. Patients and Methods Primiparous women (n = 167) were randomly assigned to one of three groups: an educational book group, a non-educational book group, or a no-book group. Home visits and interviews measured safety practices when women were in their third trimester of pregnancy (baseline) and when their child was 2, 4, 6, 9, 12, and 18 months of age. Results Women in the educational book group had fewer risks in their homes and exercised more safety practices than the no-book group (effect size = −0.30; 20% risk reduction). When the safety practices involved little time or expense (e.g., putting away sharp objects), the educational book group was significantly more likely to engage in these behaviors than the no-book (40% higher practices; effect size = 0.19) or non-educational book groups (27% higher practices; effect size = 0.13). However, no differences were found between groups for behaviors that required high effort in time, money or hassle (e.g., installing latches on cabinets). Discussion Educational baby books appear to be an easy and low cost way to increase the safety practices of new mothers, especially if the practices involve little to no time, money, and hassle. PMID:21272822

  7. Integrated Biological Control

    International Nuclear Information System (INIS)

    JOHNSON, A.R.

    2002-01-01

    Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects; and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (apriori) or in response to existing contamination spread (aposteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and apriori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, aposteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response

  8. Women in executive positions. The influence of institutional factors and gender stereotypes on women’s representation in the Peruvian presidential cabinet

    Directory of Open Access Journals (Sweden)

    Petra Poskočilová

    2015-01-01

    Full Text Available El presente artículo de reflexión trata de la represen- tación de las mujeres en el poder ejecutivo en los sistemas presidenciales, especialmente en el gabinete presidencial del Perú donde el número de las mujeres entre 2001 y 2014 aumentó del 11 a 50 %. El objetivo de este trabajo es el de examinar el impacto que otros elementos del poder, como el presidente o el parlamento, y los estereotipos de género, que posiblemente tienen sobre el nombramien- to de las mujeres. El análisis de datos se concentra en la ideología política del presidente, si es de izquierda o de derecha, y el número de las mujeres en el parlamento. En conclusión se revela el impacto de las cuotas de género para las elecciones legislativas y el número creciente de las mujeres en parlamento como los factores más influyentes sobre la representación de las mujeres en el gabinete. AbstractThis research paper deals with the representation of women in executive positions in presidential systems, specifically in a presidential cabinet of Peru, where the representation of women was progressively growing from 11 per cent in 2001 to 50 per cent in 2014. The main purpose of the article is an exploration of the impact that other components of power, like the President and the Parliament, and gender stereoptypes can have on the appointment of women. In the conclusion, the paper re- veals the impact of the legislative gender quota and relat- ed higher representation of women in parliament on the number of female ministers. 

  9. Water Safety

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Water Safety KidsHealth / For Teens / Water Safety What's in ... drownings are tied to alcohol use. At the Water Park OK, so you do more splashing than ...

  10. Water Safety

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Water Safety KidsHealth / For Parents / Water Safety What's in ... remains your best measure of protection. Making Kids Water Wise It's important to teach your kids proper ...

  11. Home Safety

    Science.gov (United States)

    ... Safety Sponsors Recalls Media Center Blog Videos Newsletter facebook twitter instagram pinterest gplus youtube Search Menu Why It Matters ... Safety Sponsors Recalls Media Center Blog Videos Newsletter facebook twitter instagram pinterest gplus youtube Sign up for quick tips ...

  12. Reactive Safety

    Directory of Open Access Journals (Sweden)

    Rüdiger Ehlers

    2011-06-01

    Full Text Available The distinction between safety and liveness properties is a fundamental classification with immediate implications on the feasibility and complexity of various monitoring, model checking, and synthesis problems. In this paper, we revisit the notion of safety for reactive systems, i.e., for systems whose behavior is characterized by the interplay of uncontrolled environment inputs and controlled system outputs. We show that reactive safety is a strictly larger class of properties than standard safety. We provide algorithms for checking if a property, given as a temporal formula or as a word or tree automaton, is a reactive safety property and for translating such properties into safety automata. Based on this construction, the standard verification and synthesis algorithms for safety properties immediately extend to the larger class of reactive safety.

  13. Safety Checklists

    National Research Council Canada - National Science Library

    1985-01-01

    The purpose of this checklist is to provide commanders, directors, safety officers, and supervisors with a ready safety reference that encompasses most functions and tasks common to operations within...

  14. ITER safety

    International Nuclear Information System (INIS)

    Raeder, J.; Piet, S.; Buende, R.

    1991-01-01

    As part of the series of publications by the IAEA that summarize the results of the Conceptual Design Activities for the ITER project, this document describes the ITER safety analyses. It contains an assessment of normal operation effluents, accident scenarios, plasma chamber safety, tritium system safety, magnet system safety, external loss of coolant and coolant flow problems, and a waste management assessment, while it describes the implementation of the safety approach for ITER. The document ends with a list of major conclusions, a set of topical remarks on technical safety issues, and recommendations for the Engineering Design Activities, safety considerations for siting ITER, and recommendations with regard to the safety issues for the R and D for ITER. Refs, figs and tabs

  15. Biological computation

    CERN Document Server

    Lamm, Ehud

    2011-01-01

    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  16. Safety handbook

    International Nuclear Information System (INIS)

    1990-01-01

    The purpose of the Australian Nuclear Science and Technology Organization's Safety Handbook is to outline simply the fundamental procedures and safety precautions which provide an appropriate framework for safe working with any potential hazards, such as fire and explosion, welding, cutting, brazing and soldering, compressed gases, cryogenic liquids, chemicals, ionizing radiations, non-ionising radiations, sound and vibration, as well as safety in the office. It also specifies the organisation for safety at the Lucas Heights Research Laboratories and the responsibilities of individuals and committees. It also defines the procedures for the scrutiny and review of all operations and the resultant setting of safety rules for them. ills

  17. Safety design

    International Nuclear Information System (INIS)

    Kunitomi, Kazuhiko; Shiozawa, Shusaku

    2004-01-01

    JAERI established the safety design philosophy of the HTTR based on that of current reactors such as LWR in Japan, considering inherent safety features of the HTTR. The strategy of defense in depth was implemented so that the safety engineering functions such as control of reactivity, removal of residual heat and confinement of fission products shall be well performed to ensure safety. However, unlike the LWR, the inherent design features of the high-temperature gas-cooled reactor (HTGR) enables the HTTR meet stringent regulatory criteria without much dependence on active safety systems. On the other hand, the safety in an accident typical to the HTGR such as the depressurization accident initiated by a primary pipe rupture shall be ensured. The safety design philosophy of the HTTR considers these unique features appropriately and is expected to be the basis for future Japanese HTGRs. This paper describes the safety design philosophy and safety evaluation procedure of the HTTR especially focusing on unique considerations to the HTTR. Also, experiences obtained from an HTTR safety review and R and D needs for establishing the safety philosophy for the future HTGRs are reported

  18. Nuclear Safety

    International Nuclear Information System (INIS)

    1978-09-01

    In this short paper it has only been possible to deal in a rather general way with the standards of safety used in the UK nuclear industry. The record of the industry extending over at least twenty years is impressive and, indeed, unique. No other industry has been so painstaking in protection of its workers and in its avoidance of damage to the environment. Headings are: introduction; how a nuclear power station works; radiation and its effects (including reference to ICRP, the UK National Radiological Protection Board, and safety standards); typical radiation doses (natural radiation, therapy, nuclear power programme and other sources); safety of nuclear reactors - design; key questions (matters of concern which arise in the public mind); safety of operators; safety of people in the vicinity of a nuclear power station; safety of the general public; safety bodies. (U.K.)

  19. New set of Chemical Safety rules

    CERN Multimedia

    HSE Unit

    2011-01-01

    A new set of four Safety Rules was issued on 28 March 2011: Safety Regulation SR-C ver. 2, Chemical Agents (en); General Safety Instruction GSI-C1, Prevention and Protection Measures (en); General Safety Instruction GSI-C2, Explosive Atmospheres (en); General Safety Instruction GSI-C3, Monitoring of Exposure to Hazardous Chemical Agents in Workplace Atmospheres (en). These documents form part of the CERN Safety Rules and are issued in application of the “Staff Rules and Regulations” and of document SAPOCO 42. These documents set out the minimum requirements for the protection of persons from risks to their occupational safety and health arising, or likely to arise, from the effects of hazardous chemical agents that are present in the workplace or used in any CERN activity. Simultaneously, the HSE Unit has published seven Safety Guidelines and six Safety Forms. These documents are available from the dedicated Web page “Chemical, Cryogenic and Biological Safety&...

  20. System for cooling a cabinet

    DEFF Research Database (Denmark)

    2015-01-01

    The present disclosure relates to a cooling system comprising an active magnetic regenerator having a cold side and a hot side, a hot side heat exchanger connected to the hot side of the magnetic regenerator, one or more cold side heat exchangers, and a cold store reservoir comprising a volume...

  1. Safety and reliability assessment

    International Nuclear Information System (INIS)

    1979-01-01

    This report contains the papers delivered at the course on safety and reliability assessment held at the CSIR Conference Centre, Scientia, Pretoria. The following topics were discussed: safety standards; licensing; biological effects of radiation; what is a PWR; safety principles in the design of a nuclear reactor; radio-release analysis; quality assurance; the staffing, organisation and training for a nuclear power plant project; event trees, fault trees and probability; Automatic Protective Systems; sources of failure-rate data; interpretation of failure data; synthesis and reliability; quantification of human error in man-machine systems; dispersion of noxious substances through the atmosphere; criticality aspects of enrichment and recovery plants; and risk and hazard analysis. Extensive examples are given as well as case studies

  2. Safety; Avertissement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This annual report of the Senior Inspector for the Nuclear Safety, analyses the nuclear safety at EDF for the year 1999 and proposes twelve subjects of consideration to progress. Five technical documents are also provided and discussed concerning the nuclear power plants maintenance and safety (thermal fatigue, vibration fatigue, assisted control and instrumentation of the N4 bearing, 1300 MW reactors containment and time of life of power plants). (A.L.B.)

  3. Visit safety

    CERN Multimedia

    2012-01-01

    Experiment areas, offices, workshops: it is possible to have co-workers or friends visit these places.     You already know about the official visits service, the VIP office, and professional visits. But do you know about the safety instruction GSI-OHS1, “Visits on the CERN site”? This is a mandatory General Safety Instruction that was created to assist you in ensuring safety for all your visits, whatever their nature—especially those that are non-official. Questions? The HSE Unit will be happy to answer them. Write to safety-general@cern.ch.   The HSE Unit

  4. Workplace Safety and Health Topics: Safety & Prevention

    Science.gov (United States)

    ... Safety Motor Vehicle Safety Motor-Vehicle Safety of Law Enforcement Officers Nail Gun Safety National Occupational Mortality Surveillance (NOMS) Noise and Hearing Loss Prevention Occupational Health Safety Network (OHSN) Occupational Hearing Loss Surveillance Occupational ...

  5. Unresolved clinical aspects and safety hazards of blood derived- EV/MV in stored blood components: From personal memory lanes to newer perspectives on the roles of EV/MV in various biological phenomena.

    Science.gov (United States)

    Seghatchian, Jerard; Amiral, Jean

    2016-08-01

    Blood cells generate heterogeneous populations of vesicles that are delivered, as small-specialized packages of highly active cell fragments in blood circulation, having almost similar functional activities, as the mother cells. These so called extracellular vesicles are the essential part of an energy-dependent natural apoptotic process; hence their beneficial and harmful biological functions cannot be ignored. Evidence is accumulating, that cellular derived vesicles, originate from all viable cells including: megakaryocytes, platelets, red blood cells, white blood cells and endothelial cells, the highest in proportions from platelets. Shedding can also be triggered by pathological activation of inflammatory processes and activation of coagulation or complement pathways, or even by shear stress in the circulation. Structurally, so called MV/EV appear to be, sometimes inside-out and sometimes outside-in cell fragments having a bilayered phospholipid structure exposing coagulant-active phosphatidylserine, expressing various membrane receptors, and they serve as cell-to-cell shuttles for bioactive molecules such as lipids, growth factors, microRNAs, and mitochondria. Ex vivo processing of blood into its components, embodying centrifugation, processing by various apheresis procedures, leukoreduction, pathogen reduction, and finally storage in different media and different types of blood bags, also have major impacts on the generation and retention of MV content. These artificially generated small, but highly liable packages, together with the original pool of MVs collected from the donor, do exhibit differing biological activities, and are not inert elements and should be considered as a parameter of blood safety in haemovigilance programmes. Harmonization and consensus in sampling protocols, sample handling, processing, and assessment methods, in particular converting to full automation, are needed to achieve consensual interpretations. This review focuses on some of

  6. Systems Biology

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, H S.

    2006-06-01

    The biology revolution over the last 50 years has been driven by the ascendancy of molecular biology. This was enthusiastically embraced by most biologists because it took us into increasingly familiar territory. It took mysterious processes, such as the replication of genetic material and assigned them parts that could be readily understood by the human mind. When we think of ''molecular machines'' as being the underlying basis of life, we are using a paradigm derived from everyday experience. However, the price that we paid was a relentless drive towards reductionism and the attendant balkanization of biology. Now along comes ''systems biology'' that promises us a solution to the problem of ''knowing more and more about less and less''. Unlike molecular biology, systems biology appears to be taking us into unfamiliar intellectual territory, such as statistics, mathematics and computer modeling. Not surprisingly, systems biology has met with widespread skepticism and resistance. Why do we need systems biology anyway and how does this new area of research promise to change the face of biology in the next couple of decades?

  7. Biological therapeutics

    National Research Council Canada - National Science Library

    Greenstein, Ben; Brook, Daniel A

    2011-01-01

    This introductory textbook covers all the main categories of biological medicines, including vaccines, hormonal preparations, drugs for rheumatoid arthritis and other connective tissue diseases, drugs...

  8. Safety Systems

    Science.gov (United States)

    Halligan, Tom

    2009-01-01

    Colleges across the country are rising to the task by implementing safety programs, response strategies, and technologies intended to create a secure environment for teachers and students. Whether it is preparing and responding to a natural disaster, health emergency, or act of violence, more schools are making campus safety a top priority. At…

  9. Safety First

    Science.gov (United States)

    Taft, Darryl

    2011-01-01

    Ned Miller does not take security lightly. As director of campus safety and emergency management at the Des Moines Area Community College (DMACC), any threat requires serious consideration. As community college administrators adopt a more proactive approach to campus safety, many institutions are experimenting with emerging technologies, including…

  10. Safety Principles

    Directory of Open Access Journals (Sweden)

    V. A. Grinenko

    2011-06-01

    Full Text Available The offered material in the article is picked up so that the reader could have a complete representation about concept “safety”, intrinsic characteristics and formalization possibilities. Principles and possible strategy of safety are considered. A material of the article is destined for the experts who are taking up the problems of safety.

  11. Is synthetic biology mechanical biology?

    Science.gov (United States)

    Holm, Sune

    2015-12-01

    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  12. Biological Agents

    Science.gov (United States)

    Powered by Translate UNITED STATES DEPARTMENT OF LABOR Facebook Twitter Instagram RSS Subscribe Search A TO Z INDEX UNITED STATES DEPARTMENT OF LABOR Facebook Twitter Instagram RSS Subscribe Occupational Safety and Health Administration English | ...

  13. Mesoscopic biology

    Indian Academy of Sciences (India)

    Abstract. In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. ... National Center for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK Campus, Bangalore 560 065, India ...

  14. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  15. Mesoscopic biology

    Indian Academy of Sciences (India)

    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological ...

  16. Safety strategy

    International Nuclear Information System (INIS)

    Schultheiss, G.F.

    1980-01-01

    The basis for safety strategy in nuclear industry and especially nuclear power plants is the prevention of radioactivity release inside or outside of the technical installation. Therefore either technical or administrative measures are combined to a general strategy concept. This introduction will explain in more detail the following topics: - basic principles of safety - lines of assurance (LOA) - defense in depth - deterministic and probabilistic methods. This presentation is seen as an introduction to the more detailed discussion following in this course, nevertheless some selected examples will be used to illustrate the aspects of safety strategy development although they might be repeated later on. (orig.)

  17. Radiation safety

    International Nuclear Information System (INIS)

    1996-04-01

    Most of the ionizing radiation that people are exposed to in day-to-day activities comes from natural, rather than manmade, sources. The health effects of radiation - both natural and artificial - are relatively well understood and can be effectively minimized through careful safety measures and practices. The IAEA, together with other international and expert organizations, is helping to promote and institute Basic Safety Standards on an international basis to ensure that radiation sources and radioactive materials are managed for both maximum safety and human benefit

  18. Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Silver, E G [ed.

    1989-01-01

    This document is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated.

  19. Safety culture

    International Nuclear Information System (INIS)

    Drukraroff, C.

    2010-01-01

    The concept of Safety Culture was defined after Chernobyl's nuclear accident in 1986. It has not been exempt from discussion interpretations, adding riders, etc..., over the last 24 years because it has to do with human behavior and performance in the organizations. Safety Culture is not an easy task to define, assess and monitor. The proof of it is that today we still discussing and writing about it. How has been the evolution of Safety Culture at the Juzbado Factory since 1985 to today?. What is the strategy that we will be following in the future. (Author)

  20. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi

    2009-06-01

    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  1. Biological Oceanography

    Science.gov (United States)

    Dyhrman, Sonya

    2004-10-01

    The ocean is arguably the largest habitat on the planet, and it houses an astounding array of life, from microbes to whales. As a testament to this diversity and its importance, the discipline of biological oceanography spans studies of all levels of biological organization, from that of single genes, to organisms, to their population dynamics. Biological oceanography also includes studies on how organisms interact with, and contribute to, essential global processes. Students of biological oceanography are often as comfortable looking at satellite images as they are electron micrographs. This diversity of perspective begins the textbook Biological Oceanography, with cover graphics including a Coastal Zone Color Scanner image representing chlorophyll concentration, an electron micrograph of a dinoflagellate, and a photograph of a copepod. These images instantly capture the reader's attention and illustrate some of the different scales on which budding oceanographers are required to think. Having taught a core graduate course in biological oceanography for many years, Charlie Miller has used his lecture notes as the genesis for this book. The text covers the subject of biological oceanography in a manner that is targeted to introductory graduate students, but it would also be appropriate for advanced undergraduates.

  2. Vaccine Safety

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search The CDC Vaccine Safety Note: Javascript is disabled or is not ... CDC.gov . Recommend on Facebook Tweet Share Compartir Vaccine Adverse Events Reporting System (VAERS) New website and ...

  3. INTERNET SAFETY

    OpenAIRE

    Sarhan M. Musa

    2017-01-01

    Safety is fundamentally important for everyone, whether online or offline and is everyone’s responsibility. Internet safety refers to how to be safe, confident, and responsible when using online technologies. Making the Internet safe for children has become a major technological challenge and a public policy issue. It is mainly taught in elementary and high schools. This paper provides a brief introduction on how individuals can keep themselves and their loved ones safe while they surf

  4. Nuclear safety

    International Nuclear Information System (INIS)

    1991-01-01

    This document brings together a series of articles illustrating the way nuclear safety is conceived organised and applied in France. It also deals with foreign experts contributions related to the safety of future nuclear power plants and the impact of probabilistic studies. The opinion of a french Deputy, pleading for nuclear transparency, is sustained by the final conclusions analysing the lessons learned from the past and the current priorities [fr

  5. Investigation regarding the safety of handling the fuel assemblies for the nuclear ship 'Mutsu'

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    It was concluded previously that the general inspection of safety and the repair of shielding can be carried out as the fuel assemblies are charged, and the safety can be secured sufficiently. According to the decision by the meeting of cabinet ministers concerned with the nuclear ship ''Mutsu'', the Mutsu General Inspection and Repair Technology Investigation Committee investigated on the basic concept regarding the method and the safety of taking out, transporting and preserving the fuel assemblies. 112 fuel rods and 9 burnable poison rods are arranged into the square grid of 11 x 11 in a fuel assembly, and 32 fuel assemblies are employed. The contents of the investigation are the outline of the fuel assemblies, the present states of nuclear fission products, surface dose rate and soundness of the fuel assemblies, the safety of taking out, transporting and preserving the fuel assemblies, the measures required for securing the safety, and the place for taking out the fuel assemblies. In case of taking out, transporting and preserving the fuel assemblies, it is considered in view of the present state of the fuel assemblies that the safety can be secured sufficiently if the works are carried out carefully by taking the methods and conditions investigated into consideration. Also the committee reached already the conclusion described at the outset. (Kako, I.)

  6. Biological Pathways

    Science.gov (United States)

    Skip to main content Biological Pathways Fact Sheet Enter Search Term(s): Español Research Funding An Overview Bioinformatics Current Grants Education and Training Funding Extramural Research News Features ...

  7. Safety first!

    CERN Multimedia

    2016-01-01

    Among the many duties I assumed at the beginning of the year was the ultimate responsibility for Safety at CERN: the responsibility for the physical safety of the personnel, the responsibility for the safe operation of the facilities, and the responsibility to ensure that CERN acts in accordance with the highest standards of radiation and environmental protection.   The Safety Policy document drawn up in September 2014 is an excellent basis for the implementation of Safety in all areas of CERN’s work. I am happy to commit during my mandate to help meet its objectives, not least by ensuring the Organization makes available the necessary means to achieve its Safety objectives. One of the main objectives of the HSE (Occupational Health and Safety and Environmental Protection) unit in the coming months is to enhance the measures to minimise CERN’s impact on the environment. I believe CERN should become a role model for an environmentally-aware scientific research laboratory. Risk ...

  8. Electromagnetic fields in biological systems

    CERN Document Server

    Lin, James C

    2016-01-01

    As wireless technology becomes more sophisticated and accessible to more users, the interactions of electromagnetic fields with biological systems have captured the interest not only of the scientific community but also the general public. Unintended or deleterious biological effects of electromagnetic fields and radiation may indicate grounds for health and safety precautions in their use. Spanning static fields to terahertz waves, Electromagnetic Fields in Biological Systems explores the range of consequences these fields have on the human body. With contributions by an array of experts, topics discussed include: Essential interactions and field coupling phenomena, highlighting their importance in research on biological effects and in scientific, industrial, and medical applications Electric field interactions in cells, focusing on ultrashort, pulsed high-intensity fields The effect of exposure to naturally occurring and human-made static, low-frequency, and pulsed magnetic fields in biological systems Dosi...

  9. Illuminating Cell Biology

    Science.gov (United States)

    2002-01-01

    NASA's Ames Research Center awarded Ciencia, Inc., a Small Business Innovation Research contract to develop the Cell Fluorescence Analysis System (CFAS) to address the size, mass, and power constraints of using fluorescence spectroscopy in the International Space Station's Life Science Research Facility. The system will play an important role in studying biological specimen's long-term adaptation to microgravity. Commercial applications for the technology include diverse markets such as food safety, in situ environmental monitoring, online process analysis, genomics and DNA chips, and non-invasive diagnostics. Ciencia has already sold the system to the private sector for biosensor applications.

  10. A review of biological processes within oceanic water columns relevant to the assessment of the safety of disposal of waste, notably radioactive isotopes on or within the sea bed

    International Nuclear Information System (INIS)

    Angel, M.V.

    1985-01-01

    Pelagic biological processes and their connotations in the assessment of possible dispersal mechanisms of contaminants released on the deep oceanic seabed are reviewed. Biological gradients tend to be from the surface down so the search is for processes which run counter to these general gradients. Observed profiles of standing crop of both plankton and micronekton show that below 2000 m biological activity would have to be exceptionally dynamic to have an influence that will even approach within an order of magnitude of the dispersive effect of physical mixing. Examination of all forms of known migration mechanisms fails to reveal such dynamic activity. Nor have any critical pathways been identified within the present or foreseeable pattern of exploitation of the oceans. However, a major gap in knowledge is whether the pattern of these biological processes changes substantially in the region of continental slopes. (author)

  11. 31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

    CERN Multimedia

    Raphaël Piguet

    2011-01-01

    31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

  12. SAFETY INSTRUCTION AND SAFETY NOTE

    CERN Multimedia

    TIS Secretariat

    2002-01-01

    Please note that the SAFETY INSTRUCTION N0 49 (IS 49) and the SAFETY NOTE N0 28 (NS 28) entitled respectively 'AVOIDING CHEMICAL POLLUTION OF WATER' and 'CERN EXHIBITIONS - FIRE PRECAUTIONS' are available on the web at the following urls: http://edms.cern.ch/document/335814 and http://edms.cern.ch/document/335861 Paper copies can also be obtained from the TIS Divisional Secretariat, email: TIS.Secretariat@cern.ch

  13. System safety education focused on flight safety

    Science.gov (United States)

    Holt, E.

    1971-01-01

    The measures necessary for achieving higher levels of system safety are analyzed with an eye toward maintaining the combat capability of the Air Force. Several education courses were provided for personnel involved in safety management. Data include: (1) Flight Safety Officer Course, (2) Advanced Safety Program Management, (3) Fundamentals of System Safety, and (4) Quantitative Methods of Safety Analysis.

  14. Biological agents in polyarticular juvenile idiopathic arthritis

    DEFF Research Database (Denmark)

    Amarilyo, Gil; Tarp, Simon; Foeldvari, Ivan

    2016-01-01

    (nearly all exceptions were in agreement with the original study data). Serious AEs occurred very infrequently (0-8%) and an analysis was not possible. There were no differences for AEs when compared among biological agents or to placebo. CONCLUSION: There were no statistical differences among biological......BACKGROUND AND OBJECTIVE: Although various biological agents are in use for polyarticular juvenile idiopathic arthritis (pJIA), head-to-head trials comparing the efficacy and safety among them are lacking. We aimed to compare the efficacy and safety of biological agents in pJIA using all currently...... available randomized withdrawal trials (wRCTs). METHODS: A systematic search of MEDLINE, EMBASE, CENTRAL, and clinicaltrials.gov was performed. Eligible wRCTs: patients with pJIA where a biological agent was compared with another biological agent or placebo. Efficacy was evaluated using disease flare...

  15. Biological preconcentrator

    Science.gov (United States)

    Manginell, Ronald P [Albuquerque, NM; Bunker, Bruce C [Albuquerque, NM; Huber, Dale L [Albuquerque, NM

    2008-09-09

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  16. Safety organization

    International Nuclear Information System (INIS)

    Lutz, M.

    1984-06-01

    After a rapid definition of a nuclear basis installation, the national organization of nuclear safety in France is presented, as also the main organizations concerned and their functions. This report shows how the licensing procedure leading to the construction and exploitation of such installations is applied in the case of nuclear laboratories of research and development: examinations of nuclear safety problems are carried out at different levels: - centralized to define the frame out of which the installation has not to operate, - decentralized to follow in a more detailed manner its evolution [fr

  17. Operational safety

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The PNL Safety, Standards and Compliance Program contributed to the development and issuance of safety policies, standards, and criteria; for projects in the nuclear and nonnuclear areas. During 1976 the major emphasis was on developing criteria, instruments and methods to assure that radiation exposure to occupational personnel and to people in the environs of nuclear-related facilities is maintained at the lowest level technically and economically practicable. Progress in 1976 is reported on the preparation of guidelines for radiation exposure; Pu dosimetry studies; the preparation of an environmental monitoring handbook; and emergency instrumentation preparedness

  18. Biological rhythms

    Science.gov (United States)

    Halberg, F.

    1975-01-01

    An overview is given of basic features of biological rhythms. The classification of periodic behavior of physical and psychological characteristics as circadian, circannual, diurnal, and ultradian is discussed, and the notion of relativistic time as it applies in biology is examined. Special attention is given to circadian rhythms which are dependent on the adrenocortical cycle. The need for adequate understanding of circadian variations in the basic physiological indicators of an individual (heart rate, body temperature, systolic and diastolic blood pressure, etc.) to ensure the effectiveness of prophylactic and therapeutic measures is stressed.

  19. Marine Biology

    Science.gov (United States)

    Dewees, Christopher M.; Hooper, Jon K.

    1976-01-01

    A variety of informational material for a course in marine biology or oceanology at the secondary level is presented. Among the topics discussed are: food webs and pyramids, planktonic blooms, marine life, plankton nets, food chains, phytoplankton, zooplankton, larval plankton and filter feeders. (BT)

  20. Mesoscopic biology

    Indian Academy of Sciences (India)

    Abstract. In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in ...

  1. Scaffolded biology.

    Science.gov (United States)

    Minelli, Alessandro

    2016-09-01

    Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as Dawkins' extended phenotype, Turner's extended organism, Oyama's Developmental Systems Theory and Odling-Smee's niche construction theory. Last in time is the description of biological phenomena in terms of hybrids between an organism (scaffolded system) and a living or non-living scaffold, forming unit systems to study processes such as reproduction and development. As scaffold, eventually, we can define any resource used by the biological system, especially in development and reproduction, without incorporating it as happens in the case of resources fueling metabolism. Addressing biological systems as functionally scaffolded systems may help pointing to functional relationships that can impart temporal marking to the developmental process and thus explain its irreversibility; revisiting the boundary between development and metabolism and also regeneration phenomena, by suggesting a conceptual framework within which to investigate phenomena of regular hypermorphic regeneration such as characteristic of deer antlers; fixing a periodization of development in terms of the times at which a scaffolding relationship begins or is terminated; and promoting plant galls to legitimate study objects of developmental biology.

  2. Biological digestion

    International Nuclear Information System (INIS)

    Rosevear, A.

    1988-01-01

    This paper discusses the biological degradation of non-radioactive organic material occurring in radioactive wastes. The biochemical steps are often performed using microbes or isolated enzymes in combination with chemical steps and the aim is to oxidise the carbon, hydrogen, nitrogen and sulphur to their respective oxides. (U.K.)

  3. Biology Notes.

    Science.gov (United States)

    School Science Review, 1981

    1981-01-01

    Outlines a variety of laboratory procedures, techniques, and materials including construction of a survey frame for field biology, a simple tidal system, isolation and applications of plant protoplasts, tropisms, teaching lung structure, and a key to statistical methods for biologists. (DS)

  4. Online Safety.

    Science.gov (United States)

    Levine, Elliott

    2001-01-01

    Describes provisions of Children's Internet Protection Act, which school districts are required to implement on or before October 31, 2001, involving the development and public dissemination of federally mandated Internet-safety policy to prevent minors from accessing inappropriate and harmful material. Provides suggestions to protect children…

  5. Auto Safety

    Science.gov (United States)

    ... booster seat. All kids under 13 years of age should always ride in the back seat, and in the middle of the back seat whenever possible. All passengers must have their seatbelts buckled. The LATCH System Since September 2002, most new vehicles have safety seat anchorage points and most ...

  6. Playground Safety.

    Science.gov (United States)

    Sipes, James L.

    2000-01-01

    Discusses the issues of risk, liability, and fun when landscaping playgrounds with safety in mind. The importance of playground surfaces and several preventive measures landscapers can use to reduce the risk of injury are discussed. Concluding comments address playground design features and liability. (GR)

  7. Patient safety

    African Journals Online (AJOL)

    The casual observer may think that the topic of this article refers to the security available to minimise personal violence and theft, sadly speaking of a local bias. However, it refers to measures and systems that have to be put in place to minimise medical error and patient harm. The patient safety movement is now 13 years.

  8. Report on the Biological Monitoring Program at Paducah Gaseous Diffusion Plant December 1992--December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Hinzman, R.L.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1995-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The goals of BMP are to demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, characterize potential health and environmental impacts, document the effects of pollution abatement facilities on stream biota, and recommend any program improvements that would increase effluent treatability. The BMP for PGDP consists of three major tasks: effluent and ambient toxicity monitoring, bioaccumulation studies, and ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1992 to December 1993, although activities conducted outside this time period are included as appropriate.

  9. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992.

  10. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992

  11. Biologic Scaffolds.

    Science.gov (United States)

    Costa, Alessandra; Naranjo, Juan Diego; Londono, Ricardo; Badylak, Stephen F

    2017-09-01

    Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix are commonly used for the repair and functional reconstruction of injured and missing tissues. These naturally occurring bioscaffolds are manufactured by the removal of the cellular content from source tissues while preserving the structural and functional molecular units of the remaining extracellular matrix (ECM). The mechanisms by which these bioscaffolds facilitate constructive remodeling and favorable clinical outcomes include release or creation of effector molecules that recruit endogenous stem/progenitor cells to the site of scaffold placement and modulation of the innate immune response, specifically the activation of an anti-inflammatory macrophage phenotype. The methods by which ECM biologic scaffolds are prepared, the current understanding of in vivo scaffold remodeling, and the associated clinical outcomes are discussed in this article. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  12. Biologics in spine arthrodesis.

    Science.gov (United States)

    Kannan, Abhishek; Dodwad, Shah-Nawaz M; Hsu, Wellington K

    2015-06-01

    Spine fusion is a tool used in the treatment of spine trauma, tumors, and degenerative disorders. Poor outcomes related to failure of fusion, however, have directed the interests of practitioners and scientists to spinal biologics that may impact fusion at the cellular level. These biologics are used to achieve successful arthrodesis in the treatment of symptomatic deformity or instability. Historically, autologous bone grafting, including iliac crest bong graft harvesting, had represented the gold standard in spinal arthrodesis. However, due to concerns over potential harvest site complications, supply limitations, and associated morbidity, surgeons have turned to other bone graft options known for their osteogenic, osteoinductive, and/or osteoconductive properties. Current bone graft selection includes autograft, allograft, demineralized bone matrix, ceramics, mesenchymal stem cells, and recombinant human bone morphogenetic protein. Each pose their respective advantages and disadvantages and are the focus of ongoing research investigating the safety and efficacy of their use in the setting of spinal fusion. Rh-BMP2 has been plagued by issues of widespread off-label use, controversial indications, and a wide range of adverse effects. The risks associated with high concentrations of exogenous growth factors have led to investigational efforts into nanotechnology and its application in spinal arthrodesis through the binding of endogenous growth factors. Bone graft selection remains critical to successful fusion and favorable patient outcomes, and orthopaedic surgeons must be educated on the utility and limitations of various biologics in the setting of spine arthrodesis.

  13. Biological radioprotector

    International Nuclear Information System (INIS)

    Stefanescu, Ioan; Titescu, Gheorghe; Tamaian, Radu; Haulica, Ion; Bild, Walther

    2002-01-01

    According to the patent description, the biological radioprotector is deuterium depleted water, DDW, produced by vacuum distillation with an isotopic content lower than natural value. It appears as such or in a mixture with natural water and carbon dioxide. It can be used for preventing and reducing the ionizing radiation effects upon humans or animal organisms, exposed therapeutically, professionally or accidentally to radiation. The most significant advantage of using DDW as biological radioprotector results from its way of administration. Indeed no one of the radioprotectors currently used today can be orally administrated, what reduces the patients' compliance to prophylactic administrations. The biological radioprotector is an unnoxious product obtained from natural water, which can be administrated as food additive instead of drinking water. Dose modification factor is according to initial estimates around 1.9, what is a remarkable feature when one takes into account that the product is toxicity-free and side effect-free and can be administrated prophylactically as a food additive. A net radioprotective action of the deuterium depletion was evidenced experimentally in laboratory animals (rats) hydrated with DDW of 30 ppm D/(D+H) concentration as compared with normally hydrated control animals. Knowing the effects of irradiation and mechanisms of the acute radiation disease as well as the effects of administration of radiomimetic chemicals upon cellular lines of fast cell division, it appears that the effects of administrating DDW result from stimulation of the immunity system. In conclusion, the biological radioprotector DDW presents the following advantages: - it is obtained from natural products without toxicity; - it is easy to be administrated as a food additive, replacing the drinking water; - besides radioprotective effects, the product has also immunostimulative and antitumoral effects

  14. Crusts: biological

    Science.gov (United States)

    Belnap, Jayne; Elias, Scott A.

    2013-01-01

    Biological soil crusts, a community of cyanobacteria, lichens, mosses, and fungi, are an essential part of dryland ecosystems. They are critical in the stabilization of soils, protecting them from wind and water erosion. Similarly, these soil surface communities also stabilized soils on early Earth, allowing vascular plants to establish. They contribute nitrogen and carbon to otherwise relatively infertile dryland soils, and have a strong influence on hydrologic cycles. Their presence can also influence vascular plant establishment and nutrition.

  15. Marine biology

    International Nuclear Information System (INIS)

    Thurman, H.V.; Webber, H.H.

    1984-01-01

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index

  16. Safety Note

    CERN Multimedia

    SC Secretariat

    2004-01-01

    Please note that the Safety Note no 29 (NS 29) entitled 'Fire Prevention for Insulating Core (Sandwich) Panel Structures for Inside Use Guidelines for Selection, Installation and Use' is available on the web at the following url: https://edms.cern.ch/document/475438/LAST_RELEASED Paper copies can also be obtained from the SC Unit secretariat, e-mail : sc.secretariat@cern.ch SC Secretariat

  17. Cryogenics safety

    International Nuclear Information System (INIS)

    Reider, R.

    1977-01-01

    The safety hazards associated with handling cryogenic fluids are discussed in detail. These hazards include pressure buildup when a cryogenic fluid is heated and becomes a gas, potential damage to body tissues due to surface contact, toxic risk from breathing air altered by cryogenic fluids, dangers of air solidification, and hazards of combustible cryogens such as liquified oxygen, hydrogen, or natural gas or of combustible mixtures. Safe operating procedures and emergency planning are described

  18. Nuclear safety

    International Nuclear Information System (INIS)

    2014-01-01

    The Program on Nuclear Safety comprehends Radioprotection, Radioactive Waste Management and Nuclear Material Control. These activities are developed at the Nuclear Safety Directory. The Radioactive Waste Management Department (GRR) was formally created in 1983, to promote research and development, teaching and service activities in the field of radioactive waste. Its mission is to develop and employ technologies to manage safely the radioactive wastes generated at IPEN and at its customer’s facilities all over the country, in order to protect the health and the environment of today's and future generations. The Radioprotection Service (GRP) aims primarily to establish requirements for the protection of people, as workers, contractors, students, members of the general public and the environment from harmful effects of ionizing radiation. Furthermore, it also aims to establish the primary criteria for the safety of radiation sources at IPEN and planning and preparing for response to nuclear and radiological emergencies. The procedures about the management and the control of exposures to ionizing radiation are in compliance with national standards and international recommendations. Research related to the main activities is also performed. The Nuclear Material Control has been performed by the Safeguard Service team, which manages the accountability and the control of nuclear material at IPEN facilities and provides information related to these activities to ABACC and IAEA. (author)

  19. Hydrogen safety

    International Nuclear Information System (INIS)

    Frazier, W.R.

    1991-01-01

    The NASA experience with hydrogen began in the 1950s when the National Advisory Committee on Aeronautics (NACA) research on rocket fuels was inherited by the newly formed National Aeronautics and Space Administration (NASA). Initial emphasis on the use of hydrogen as a fuel for high-altitude probes, satellites, and aircraft limited the available data on hydrogen hazards to small quantities of hydrogen. NASA began to use hydrogen as the principal liquid propellant for launch vehicles and quickly determined the need for hydrogen safety documentation to support design and operational requirements. The resulting NASA approach to hydrogen safety requires a joint effort by design and safety engineering to address hydrogen hazards and develop procedures for safe operation of equipment and facilities. NASA also determined the need for rigorous training and certification programs for personnel involved with hydrogen use. NASA's current use of hydrogen is mainly for large heavy-lift vehicle propulsion, which necessitates storage of large quantities for fueling space shots and for testing. Future use will involve new applications such as thermal imaging

  20. [Biologic treatments for hereditary diseases].

    Science.gov (United States)

    Yang, Jing; Xie, Yangli; Chen, Lin

    2015-06-01

    Hereditary disease, especially monogenic disease is one of the major causes for malformation and disability of children. Most hereditary diseases have no effective therapy besides clinical symptomatic treatment. Biological techniques targeting casual genes or related signaling genes, such as transgenic, RNA interfere, genome editing, have been successfully applied in treating some hereditary diseases. However, most biological, treatments were carried out in animals, further confirmation of the effectiveness and safety of these therapies, and development of more therapeutic approaches based on mechanisms are needed before clinical trials.

  1. Nuclear safety culture and nuclear safety supervision

    International Nuclear Information System (INIS)

    Chai Jianshe

    2013-01-01

    In this paper, the author reviews systematically and summarizes up the development process and stage characteristics of nuclear safety culture, analysis the connotation and characteristics of nuclear safety culture, sums up the achievements of our country's nuclear safety supervision, dissects the challenges and problems of nuclear safety supervision. This thesis focused on the relationship between nuclear safety culture and nuclear safety supervision, they are essential differences, but there is a close relationship. Nuclear safety supervision needs to introduce some concepts of nuclear safety culture, lays emphasis on humanistic care and improves its level and efficiency. Nuclear safety supervision authorities must strengthen nuclear safety culture training, conduct the development of nuclear safety culture, make sure that nuclear safety culture can play significant roles. (author)

  2. Treating moderate to severe psoriasis - best use of biologics.

    LENUS (Irish Health Repository)

    Lynch, Maeve

    2014-02-01

    This review focuses on the efficacy, safety and best use of biologic agents in moderate-to-severe psoriasis. Recommendations from two recent guidelines are summarised. The NICE Guidelines 2012 provide recommendations on best practice for prescribing biologics. The German S3 Guidelines are based on a systematic review of published studies and report the efficacy of biologics and guidelines for treatment. Data on the safety of biologics are available for up to 5 years in psoriasis and are on the whole reassuring. Registry data is evolving and will provide data on safety to help inform long-term monitoring of patients with psoriasis on biologics agents. New anti-interleukin-17 (IL17) and anti-IL17RA biologics are in Phase 3 clinical trials and may prove to be more effective than existing biologics.

  3. Radiation safety

    International Nuclear Information System (INIS)

    Goetz, B.B.; Murphy, C.H.

    1987-01-01

    In medicine, as in other fields of scientific endeavor, the development of advanced and specialized techniques has resulted in increased hazards for employees. However, by possessing both an appreciation of the proper use of factors that regulate radiation exposure around radiology equipment and a knowledge of the biologic effects of radiation, which can include possible genetic and somatic consequences, it is possible to maximize the usefulness of these valuable procedures while minimizing the risk to medical personnel involved with patient care

  4. SAFETY NOTES

    CERN Document Server

    TIS Secretariat

    2001-01-01

    Please note that the revisions of safety notes no 3 (NS 3 Rev. 2) and no 24 (NS 24 REV.) entitled respectively 'FIRE PREVENTION FOR ENCLOSED SPACES IN LARGE HALLS' and 'REMOVING UNBURIED ELV AND LVA ELECTRIC CONDUITS' are available on the web at the following urls: http://edmsoraweb.cern.ch:8001/cedar/doc.download?document_id=322811&version=1&filename=version_francaise.pdf http://edmsoraweb.cern.ch:8001/cedar/doc.download?document_id=322861&version=2&filename=version_francaise.pdf Paper copies can also be obtained from the TIS Divisional Secretariat, email tis.secretariat@cern.ch

  5. Safety training

    CERN Multimedia

    SC Unit

    2009-01-01

    Habilitation électrique A course entitled "Habilitation électrique pour personnel de laboratoire" (electrical safety qualification for laboratory personnel) will be held on 22 and 23 June. Registration by e-mail to isabelle.cusato@cern.ch. Explosion Hazards in the handling of flammable solvents and gases A course entitled "Explosion Hazards in the handling of flammable solvents and gases" given in French will be held on 18-19 June 2009. This course is obligatory for all FGSOs at CERN, and it is recommended for anyone handling flammable gas or solvents. To sign up please visit this page. For more information please contact Isabelle Cusato, tel. 73811.

  6. Biological biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Jorge-Herrero, E. [Servicio de Cirugia Experimental. Clinica Puerta de Hierro, Madrid (Spain)

    1997-05-01

    There are a number of situations in which substances of biological origin are employed as biomaterials. Most of them are macromolecules derived from isolated connective tissue or the connective tissue itself in membrane form, in both cases, the tissue can be used in its natural form or be chemically treated. In other cases, certain blood vessels can be chemically pretreated and used as vascular prostheses. Proteins such as albumin, collagen and fibrinogen are employed to coat vascular prostheses. Certain polysaccharides have also been tested for use in controlled drug release systems. Likewise, a number of tissues, such as dura mater, bovine pericardium, procine valves and human valves, are used in the preparation of cardiac prostheses. We also use veins from animals or humans in arterial replacement. In none of these cases are the tissues employed dissimilar to the native tissues as they have been chemically modified, becoming a new bio material with different physical and biochemical properties. In short, we find that natural products are being utilized as biomaterials and must be considered as such; thus, it is necessary to study both their chemicobiological and physicomechanical properties. In the present report, we review the current applications, problems and future prospects of some of these biological biomaterials. (Author) 84 refs.

  7. Safety first

    CERN Multimedia

    2012-01-01

    Safety is a priority for CERN. That is a message I conveyed in my New Year’s address and that I reiterated at one of the first Enlarged Directorate meetings of 2012 when I outlined five key safety objectives for the year, designed and implemented according to accepted international standards.   As we move from spring to summer, it’s time to take stock of how we are doing. Objective number one for 2012, which overarches everything else, is to limit the number of incidents in the workplace. That means systematically investigating and acting on every incident that involves work stoppage, along with all the most frequent workplace accidents: falls, trips and slips. The performance indicator we set ourselves is the percentage of investigations and follow-ups completed. Year on year, these figures are rising but we can never be complacent, and must strive to reach and sustain 100% follow-up. The second objective is to improve hazard control, with a focus in 2012 on chemical ha...

  8. EFSA Panel on Biological Hazards (BIOHAZ); Scientific Opinion on the evaluation of the safety and efficacy of ListexTM P100 for the removal of Listeria monocytogenes surface contamination of raw fish

    DEFF Research Database (Denmark)

    Hald, Tine

    Studies evaluating the safety and efficacy of Listex™ P100 to reduce Listeria monocytogenes contamination on raw fish were assessed. The material should not present human toxicological problems because the bacteriophage P100, used as active principle, is not regarded as harmful to consumers nor...... in reducing L. monocytogenes counts on raw fish nor on its impact on L. monocytogenes contamination levels in finished product. It was not possible to estimate the potential listeriosis risk reduction by treating raw fish with Listex™ P100. The data were not adequate to allow firm conclusions on persistence...... or activity of P100 in stored fish. The proposed use of Listex™ P100 is unlikely to result in emergence of reduced susceptibility to biocides and/or resistance to key therapeutic antimicrobials: however, this conclusion may need verification. No information was provided on survival of P100 in processing...

  9. Biological effects

    International Nuclear Information System (INIS)

    Trott, K.R.

    1973-01-01

    Following an introduction into the field of cellular radiation effect considering the most important experimental results, the biological significance of the colony formation ability is brought out. The inactivation concept of stem cells does not only prove to be good, according to the present results, in the interpretation of the pathogenesis of acute radiation effects on moult tissue, it also enables chronicle radiation injuries to be interpreted through changes in the fibrous part of the organs. Radiation therapy of tumours can also be explained to a large extent by the radiation effect on the unlimited reproductiveness of tumour cells. The more or less similar dose effect curves for healthy and tumour tissue in practice lead to intermittent irradiation. The dependence of the intermittent doses and intervals on factors such as Elkind recovery, synchronisation, redistribution, reoxygenation, repopulation and regeneration are reviewed. (ORU/LH) [de

  10. [Safety in the Microbiology laboratory].

    Science.gov (United States)

    Rojo-Molinero, Estrella; Alados, Juan Carlos; de la Pedrosa, Elia Gómez G; Leiva, José; Pérez, José L

    2015-01-01

    The normal activity in the laboratory of microbiology poses different risks - mainly biological - that can affect the health of their workers, visitors and the community. Routine health examinations (surveillance and prevention), individual awareness of self-protection, hazard identification and risk assessment of laboratory procedures, the adoption of appropriate containment measures, and the use of conscientious microbiological techniques allow laboratory to be a safe place, as records of laboratory-acquired infections and accidents show. Training and information are the cornerstones for designing a comprehensive safety plan for the laboratory. In this article, the basic concepts and the theoretical background on laboratory safety are reviewed, including the main legal regulations. Moreover, practical guidelines are presented for each laboratory to design its own safety plan according its own particular characteristics. Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  11. Safety balance: Analysis of safety systems

    International Nuclear Information System (INIS)

    Delage, M.; Giroux, C.

    1990-12-01

    Safety analysis, and particularly analysis of exploitation of NPPs is constantly affected by EDF and by the safety authorities and their methodologies. Periodic safety reports ensure that important issues are not missed on daily basis, that incidents are identified and that relevant actions are undertaken. French safety analysis method consists of three principal steps. First type of safety balance is analyzed at the normal start-up phase for each unit including the final safety report. This enables analysis of behaviour of units ten years after their licensing. Second type is periodic operational safety analysis performed during a few years. Finally, the third step consists of safety analysis of the oldest units with the aim to improve the safety standards. The three steps of safety analysis are described in this presentation in detail with the aim to present the objectives and principles. Examples of most recent exercises are included in order to illustrate the importance of such analyses

  12. Safety first

    Energy Technology Data Exchange (ETDEWEB)

    Harvie, W.

    1997-06-01

    Expansion of international business opportunities for Canadian producers and service companies brings with it a dimension almost never considered on home base - security. It was pointed out that once abroad, safety and defence of people and equipment can become significant problems in many parts of the world. The nature of the security risks involved, and how best to deal with them, were discussed. The use of consultants, mostly foreign ones to date, and the kind of assistance they can provide, everything from written reports on the local situation to counter surveillance training, and bodyguard services, have been described. Examples of recent involvements with guerilla groups demanding `revolutionary war taxes`, kidnapping executives for ransom, due diligence investigations of potential partners, and the like, have been provided to illustrate the unique character of the problem, and the constant need for being alert, educated to risks, and being prepared to react to risk situations.

  13. Construction safety

    CERN Document Server

    Li, Rita Yi Man

    2013-01-01

    A close-to-ideal blend of suburb and city, speedy construction of towers of Babylon, the sparkling proportion of glass and steel buildings’ facade at night showcase the wisdom of humans. They also witness the footsteps, sweats and tears of architects and engineers. Unfortunately, these signatures of human civilizations are swathed in towering figures of construction accidents. Fretting about these on sites, different countries adopt different measures on sites. This book firstly sketches the construction accidents on sites, followed by a review on safety measures in some of the developing countries such as Bermuda, Egypt, Kuwait and China; as well as developed countries, for example, the United States, France and Singapore. It also highlights the enormous compensation costs with the courts’ experiences in the United Kingdom and Hong Kong.

  14. Creating biological nanomaterials using synthetic biology.

    Science.gov (United States)

    Rice, MaryJoe K; Ruder, Warren C

    2014-02-01

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems.

  15. Creating biological nanomaterials using synthetic biology

    International Nuclear Information System (INIS)

    Rice, MaryJoe K; Ruder, Warren C

    2014-01-01

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems. (review)

  16. Global safety

    Directory of Open Access Journals (Sweden)

    Dorien J. DeTombe

    2010-08-01

    Full Text Available Global Safety is a container concept referring to various threats such as HIV/Aids, floods and terrorism; threats with different causes and different effects. These dangers threaten people, the global economy and the slity of states. Policy making for this kind of threats often lack an overview of the real causes and the interventions are based on a too shallow analysis of the problem, mono-disciplinary and focus mostly only on the effects. It would be more appropriate to develop policy related to these issues by utilizing the approaches, methods and tools that have been developed for complex societal problems. Handling these complex societal problems should be done multidisciplinary instead of mono-disciplinary. In order to give politicians the opportunity to handle complex problems multidisciplinary, multidisciplinary research institutes should be created. These multidisciplinary research institutes would provide politicians with better approaches to handle this type of problem. In these institutes the knowledge necessary for the change of these problems can be created through the use of the Compram methodology which has been developed specifically for handling complex societal problems. In a six step approach, experts, actors and policymakers discuss the content of the problem and the possible changes. The framework method uses interviewing, the Group Decision Room, simulation models and scenario's in a cooperative way. The methodology emphasizes the exchange of knowledge and understanding by communication among and between the experts, actors and politicians meanwhile keeping emotion in mind. The Compram methodology will be further explained in relation to global safety in regard to terrorism, economy, health care and agriculture.

  17. FDA Regulation of Follow-On Biologics

    Science.gov (United States)

    2009-02-24

    are mostly hormones: glucagon, human growth hormone, hormones to treat infertility, hormones used to manage menopause and osteoporosis , and certain... related regulatory actions for biologics approved in the United States and the European Union.19 It found that 41 of 174 biologics approved since 1995...black box” warnings on product labels but no product withdrawals. The October 2008 study found that the probability of a first safety- related

  18. Linking Safety Analysis to Safety Requirements

    DEFF Research Database (Denmark)

    Hansen, Kirsten Mark

    Software for safety critical systems must deal with the hazards identified by safety analysistechniques: Fault trees, event trees,and cause consequence diagrams can be interpreted as safety requirements and used in the design activity. We propose that the safety analysis and the system design use...... the same system model and that this model is formalized in a real-time, interval logic, based on a conventional dynamic systems model with a state over time. The three safety analysis techniques are interpreted in this model and it is shown how to derive safety requirements for components of a system....

  19. Safety of Research Reactors. Safety Requirements

    International Nuclear Information System (INIS)

    2010-01-01

    The main objective of this Safety Requirements publication is to provide a basis for safety and a basis for safety assessment for all stages in the lifetime of a research reactor. Another objective is to establish requirements on aspects relating to regulatory control, the management of safety, site evaluation, design, operation and decommissioning. Technical and administrative requirements for the safety of research reactors are established in accordance with these objectives. This Safety Requirements publication is intended for use by organizations engaged in the site evaluation, design, manufacturing, construction, operation and decommissioning of research reactors as well as by regulatory bodies

  20. CERN's new safety policy

    CERN Multimedia

    2014-01-01

    The documents below, published on 29 September 2014 on the HSE website, together replace the document SAPOCO 42 as well as Safety Codes A1, A5, A9, A10, which are no longer in force. As from the publication date of these documents any reference made to the document SAPOCO 42 or to Safety Codes A1, A5, A9 and A10 in contractual documents or CERN rules and regulations shall be deemed to constitute a reference to the corresponding provisions of the documents listed below.   "The CERN Safety Policy" "Safety Regulation SR-SO - Responsibilities and organisational structure in matters of Safety at CERN" "General Safety Instruction GSI-SO-1 - Departmental Safety Officer (DSO)" "General Safety Instruction GSI-SO-2 - Territorial Safety Officer (TSO)" "General Safety Instruction GSI-SO-3 - Safety Linkperson (SLP)" "General Safety Instruction GSI-SO-4 - Large Experiment Group Leader In Matters of Safety (LEXGLI...

  1. Safety analysis fundamentals

    International Nuclear Information System (INIS)

    Wright, A.C.D.

    2002-01-01

    This paper discusses the safety analysis fundamentals in reactor design. This study includes safety analysis done to show consequences of postulated accidents are acceptable. Safety analysis is also used to set design of special safety systems and includes design assist analysis to support conceptual design. safety analysis is necessary for licensing a reactor, to maintain an operating license, support changes in plant operations

  2. Contractor safety

    International Nuclear Information System (INIS)

    Blanton, M.L.; Montgomery, E.W.

    1991-01-01

    The recent trend in the United States and Shell Oil Company EandP has been to increase use of contractors to do specialized work. Many companies now use contractors almost exclusively for operations such as drilling, well workovers, construction, and many specialty and routine maintenance tasks. Today, approximately 75% of Shell Oil Company's actual operating work force in EandP is contract. Clearly, HSandE considerations must become an increasingly important part of the contractor selection process. This paper reports on the Shell Oil Company's evolution from a bidder selection process to a program of Matching Owner and Contractor. Well has begun to expand efforts to make better assessments of contractor's HSandE capabilities and values in pre-bid considerations. Focus is on pre-bid evaluations to select contractors that have strong HSandE commitments and values. Contractor safety performance in this industry must be brought up to the same standards as operating companies. In Shell Oil EandP is only willing to contractors who can and are willing to do that

  3. Patient safety: Safety culture and patient safety ethics

    DEFF Research Database (Denmark)

    Madsen, Marlene Dyrløv

    2006-01-01

    Patient safety - the prevention of medical error and adverse events - and the initiative of developing safety cultures to assure patients from harm have become one of the central concerns in quality improvement in healthcare both nationally andinternationally. This subject raises numerous......,demonstrating significant, consistent and sometimes large differences in terms of safety culture factors across the units participating in the survey. Paper 5 is the results of a study of the relation between safety culture, occupational health andpatient safety using a safety culture questionnaire survey...... challenging issues of systemic, organisational, cultural and ethical relevance, which this dissertation seeks to address through the application of different disciplinary approaches. The main focus of researchis safety culture; through empirical and theoretical studies to comprehend the phenomenon, address...

  4. The SISIFO project: Seismic Safety at High Schools

    Science.gov (United States)

    Peruzza, Laura; Barnaba, Carla; Bragato, Pier Luigi; Dusi, Alberto; Grimaz, Stefano; Malisan, Petra; Saraò, Angela; Mucciarelli, Marco

    2014-05-01

    For many years, the Italian scientific community has faced the problem of the reduction of earthquake risk using innovative educational techniques. Recent earthquakes in Italy and around the world have clearly demonstrated that seismic codes alone are not able to guarantee an effective mitigation of risk. After the tragic events of San Giuliano di Puglia (2002), where an earthquake killed 26 school children, special attention was paid in Italy to the seismic safety of schools, but mainly with respect to structural aspects. Little attention has been devoted to the possible and even significant damage to non-structural elements (collapse of ceilings, tipping of cabinets and shelving, obstruction of escape routes, etc..). Students and teachers trained on these aspects may lead to a very effective preventive vigilance. Since 2002, the project EDURISK (www.edurisk.it) proposed educational tools and training programs for schools, at primary and middle levels. More recently, a nationwide campaign aimed to adults (www.iononrischio.it) was launched with the extensive support of civil protection volounteers. There was a gap for high schools, and Project SISIFO was designed to fill this void and in particular for those schools with technical/scientific curricula. SISIFO (https://sites.google.com/site/ogssisifo/) is a multidisciplinary initiative, aimed at the diffusion of scientific culture for achieving seismic safety in schools, replicable and can be structured in training the next several years. The students, helped by their teachers and by experts from scientific institutions, followed a course on specialized training on earthquake safety. The trial began in North-East Italy, with a combination of hands-on activities for the measurement of earthquakes with low-cost instruments and lectures with experts in various disciplines, accompanied by specifically designed teaching materials, both on paper and digital format. We intend to raise teachers and students knowledge of the

  5. A major safety overhaul

    CERN Multimedia

    2003-01-01

    A redefined policy, a revamped safety course, an environmental project... the TIS (Technical Inspection and Safety) Division has begun a major safety overhaul. Its new head, Wolfgang Weingarten, explains to the Bulletin why and how this is happening.

  6. Car Seat Safety

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Car Seat Safety KidsHealth / For Parents / Car Seat Safety ... certified child passenger safety technician.) Guidelines for Choosing Car Seats Choose a seat with a label that ...

  7. Behavioral based safety approaches

    International Nuclear Information System (INIS)

    Maria Michael Raj, I.

    2009-01-01

    Approach towards the establishment of positive safety culture at Heavy Water Plant, Tuticorin includes the adoption of several important methodologies focused on human behavior and culminates with achievement of Total Safety Culture where Quality and Productivity are integrated with Safety

  8. Highway safety design workshops.

    Science.gov (United States)

    2010-11-01

    Highway safety is an ongoing concern for the Texas Department of Transportation (TxDOT). As part of its : proactive commitment to improving highway safety, TxDOT is moving toward including quantitative safety : analyses earlier in the project develop...

  9. Bathroom safety - adults

    Science.gov (United States)

    Older adult bathroom safety; Falls - bathroom safety ... You may need to have safety bars in your bathroom. These grab bars should be secured vertically or horizontally to the wall, not diagonally. DO NOT use ...

  10. Bathroom safety - children

    Science.gov (United States)

    Well child - bathroom safety ... be put in charge of a younger child's safety. There should be an adult in the bathroom ... sure grandparents, friends, and other caretakers follow bathroom safety guidelines. Make sure your child's daycare also follows ...

  11. Roadway safety design workbook.

    Science.gov (United States)

    2009-07-01

    Highway safety is an ongoing concern to the Texas Department of Transportation (TxDOT). As part of its : proactive commitment to improving highway safety, TxDOT is moving toward including quantitative safety : analyses earlier in the project developm...

  12. New design of engineered safety features-component control system to improve performance and reliability

    International Nuclear Information System (INIS)

    Kim, S.T.; Jung, H.W.; Lee, S.J.; Cho, C.H.; Kim, D.H.; Kim, H.

    2006-01-01

    Full text: Full text: The Engineered Safety Features-Component Control System (ESF-CCS) controls the engineered safety features of a Nuclear Power Plant such as Solenoid Operated Valves (SOV), Motor Operated Valves (MOV), pumps, dampers, etc. to mitigate the effects of a Design Basis Accident (DBA) or an abnormal operation. ESF-CCS serves as an interface system between the Plant Protection System (PPS) and remote actuation devices. ESF-CCS is composed of fault tolerant Group Controllers GC, Loop Controllers (LC), ESF-CCS Test and Interface Processor (ETIP) and Cabinet Operator Module (COM) and Control Channel Gateway (CCG) etc. GCs in each division are designed to be fully independent triple configuration, which perform system level NSSS and BOP ESFAS logic (2-out-of-4 logic and l-out-of-2 logic, respectively) making it possible to test each GC individually during normal operation. In the existing configuration, the safety-related plant component control is part of the Plant Control System (PCS) non-safety system. For increased safety and reliability, this design change incorporates this part into the LCs, and is therefore designed according to the safety-critical system procedures. The test and diagnosis capabilities of ETIP and COM are reinforced. By means of an automatic periodic test for all main functions of the system, it is possible to quickly determine an abnormal status of the system, and to decrease the elapsed time for tests, thus effectively increasing availability. ESF-CCS consists of four independent divisions (A, B, C, and D) in the Advanced Power Reactor 1400 (APR1400). One prototype division is being manufactured and will be tested

  13. Utilisation de lignes directrices dans le cadre de l’implantation de cabinets automatisés décentralisés en établissement de santé

    Science.gov (United States)

    Brisseau, Lionel; Bussières, Jean-François; Lebel, Denis; Atkinson, Suzanne; Robinette, Louise; Fortin, Sylvie; Lemay, Michel

    2011-01-01

    RÉSUMÉ Contexte : Il existe peu de données sur les conséquences de l’utilisation des cabinets automatisés décentralisés (CAD) en établissements de santé. Méthode : Il s’agit d’une étude descriptive de la conformité des pratiques par rapport à des lignes directrices publiées dans le cadre de l’implantation de CAD. L’objectif principal de l’étude est d’évaluer la conformité globale et celle de chaque processus du circuit du médicament. L’étude se déroule au sein du Centre hospitalier universitaire (CHU) Sainte-Justine, un établissement mère–enfant de 500 lits. À partir des lignes directrices portant sur l’utilisation sécuritaire des CAD de l’Institute for Safe Medication Practice (aux États-Unis) (2008) et de son outil d’autoévaluation (2009), nous avons évalué la conformité de la pratique à 30 jours et à 120 jours après l’implantation. Résultats : Nous avons procédé de novembre 2009 à avril 2010 à l’implantation de sept stations de CAD au sein du CHU Sainte-Justine. Le profil de conformité est passé de 66 % à 74 % de janvier à avril 2010. Pour chaque processus relatif à l’utilisation sécuritaire des CAD, nous présentons une brève description des critères ainsi que les éléments de non-conformité liés à la technologie ou aux aspects organisationnels. Pour chaque élément de non-conformité, nous avons déterminé les actions requises auprès du fabricant afin de modifier l’équipement (c. à .d. aspects technologiques) et auprès de l’établissement afin de modifier les modalités d’utilisation (aspects organisationnels) en précisant le ou les processus impliqués. Conclusion : Cette étude décrit la conformité des pratiques au CHU Sainte-Justine par rapport à des lignes directrices publiées par l’Institute for Safe Medication Practices. L’utilisation de lignes directrices dans le cadre de l’implantation de cabinets automatisés décentralisés en établissement peut

  14. Nuclear criticality safety guide

    International Nuclear Information System (INIS)

    Pruvost, N.L.; Paxton, H.C.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators

  15. Nuclear criticality safety guide

    Energy Technology Data Exchange (ETDEWEB)

    Pruvost, N.L.; Paxton, H.C. [eds.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  16. Farm Health and Safety

    Science.gov (United States)

    ... jobs in the United States. Farms have many health and safety hazards, including Chemicals and pesticides Machinery, ... equipment can also reduce accidents. Occupational Safety and Health Administration

  17. New Safety rules

    CERN Multimedia

    Safety Commission

    2008-01-01

    The revision of CERN Safety rules is in progress and the following new Safety rules have been issued on 15-04-2008: Safety Procedure SP-R1 Establishing, Updating and Publishing CERN Safety rules: http://cern.ch/safety-rules/SP-R1.htm; Safety Regulation SR-S Smoking at CERN: http://cern.ch/safety-rules/SR-S.htm; Safety Regulation SR-M Mechanical Equipment: http://cern.ch/safety-rules/SR-M.htm; General Safety Instruction GSI-M1 Standard Lifting Equipment: http://cern.ch/safety-rules/GSI-M1.htm; General Safety Instruction GSI-M2 Standard Pressure Equipment: http://cern.ch/safety-rules/GSI-M2.htm; General Safety Instruction GSI-M3 Special Mechanical Equipment: http://cern.ch/safety-rules/GSI-M3.htm. These documents apply to all persons under the Director General’s authority. All Safety rules are available at the web page: http://www.cern.ch/safety-rules The Safety Commission

  18. MedWatch Safety Alerts for Human Medical Products

    Data.gov (United States)

    U.S. Department of Health & Human Services — MedWatch alerts provide timely new safety information on human drugs, medical devices, vaccines and other biologics, dietary supplements, and cosmetics. The alerts...

  19. Food Safety for People with HIV/AIDS

    Science.gov (United States)

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Food Home Food Foodborne Illness & Contaminants People at Risk of Foodborne Illness Food Safety for People with HIV/AIDS Share Tweet ...

  20. Step Therapy And Biologics: No Easy Answers

    OpenAIRE

    HAGLAND, MARK

    2006-01-01

    For what diseases is it best to try traditional drug therapies first, and are there any instances in which going straight to the biologic is reasonable? Doctors and patients want the latest and greatest, but payers want better safety and efficacy data.

  1. More safety by improving the safety culture

    International Nuclear Information System (INIS)

    Laaksonen, J.

    1993-01-01

    In its meeting in 1986, after Chernobyl accident, the INSAG group concluded, that the most important reason for the accident was lack of safety culture. Later the group realized that the safety culture, if it is well enough, can be used as a powerful tool to assess and develop practices affecting safety in any country. A comprehensive view on the various aspects of safety culture was presented in the INSAG-4 report published in 1991. Finland was among the first nations include the concept of safety culture in its regulations. This article describes the roles of government and the regulatory body in creating a national safety culture. How safety culture is seen in the operation of a nuclear power plant is also discussed. (orig.)

  2. Biological effects of radiation

    International Nuclear Information System (INIS)

    2013-01-01

    This fourth chapter presents: cell structure and metabolism; radiation interaction with biological tissues; steps of the production of biological effect of radiation; radiosensitivity of tissues; classification of biological effects; reversibility, transmissivity and influence factors; pre-natal biological effects; biological effects in therapy and syndrome of acute irradiation

  3. IAEA Safety Standards

    International Nuclear Information System (INIS)

    2016-09-01

    The IAEA Safety Standards Series comprises publications of a regulatory nature covering nuclear safety, radiation protection, radioactive waste management, the transport of radioactive material, the safety of nuclear fuel cycle facilities and management systems. These publications are issued under the terms of Article III of the IAEA’s Statute, which authorizes the IAEA to establish “standards of safety for protection of health and minimization of danger to life and property”. Safety standards are categorized into: • Safety Fundamentals, stating the basic objective, concepts and principles of safety; • Safety Requirements, establishing the requirements that must be fulfilled to ensure safety; and • Safety Guides, recommending measures for complying with these requirements for safety. For numbering purposes, the IAEA Safety Standards Series is subdivided into General Safety Requirements and General Safety Guides (GSR and GSG), which are applicable to all types of facilities and activities, and Specific Safety Requirements and Specific Safety Guides (SSR and SSG), which are for application in particular thematic areas. This booklet lists all current IAEA Safety Standards, including those forthcoming

  4. Safety considerations in MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kanal, E.; Shellock, F.G.; Talagala, L. (Univ. of Pittsburgh, PA (USA))

    1990-09-01

    The authors identify eight areas of potential safety concern during clinical magnetic resonance (MR) imaging. These include (a) biologic effects of the static magnetic field; (b) ferromagnetic attractive projectile effects of the static magnetic field; (c) potential effects of the relatively slowly time-varying magnetic field gradients; (d) effects of the rapidly varying radio-frequency (RF) magnetic fields, including RF power deposition concerns; (e) auditory considerations from noise caused by the rapidly pulsed magnetic field gradients; (f) safety considerations concerning superconductive systems, including quenches, use of cryogens, and cryogen storage and handling; (g) psychological effects, such as claustrophobia and anxiety induced because of the examination; and (h) possible effects of the intravenous use of the MR contrast agent gadopentetate dimeglumine. The concerns in each of these categories are elaborated upon, and the available data are presented to clarify their status.155 references.

  5. Nuclear Powerplant Safety: Operations.

    Science.gov (United States)

    Department of Energy, Washington, DC. Nuclear Energy Office.

    Powerplant systems and procedures that ensure the day-to-day health and safety of people in and around the plant is referred to as operational safety. This safety is the result of careful planning, good engineering and design, strict licensing and regulation, and environmental monitoring. Procedures that assure operational safety at nuclear…

  6. Fusion safety status report

    International Nuclear Information System (INIS)

    1986-10-01

    This report includes information on a) tritium handling and safety; b) activation product generation and release; c) lithium safety; d) superconducting magnet safety; e) operational safety and shielding; f) environmental impact; g) recycling, decommissioning and waste management; and h) accident analysis. Recommendations for high priority research and development are presented, as well as the current status in each area

  7. School Bus Safety Report.

    Science.gov (United States)

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    This publication provides a summary and update of school bus-safety activities conducted by the National Highway Traffic Safety Administration (NHTSA). This report discusses Congressional mandates and NHTSA's actions to improve school-bus safety (which include programs that affect human behavior and motor-vehicle safety performance), the magnitude…

  8. Safety assessment of Linum usitatissimum (Linn.) Ingestion in New ...

    African Journals Online (AJOL)

    Background: The therapeutic safety of herbal medicine is a major concern for consumers and users. After studying the effects of linseed on hair growth in rabbits, the turn is to evaluate its safety by the observation of some clinical, biological and anatomo-pathological aspects. Materials and Methods: A study was conducted ...

  9. Safety at CERN

    CERN Multimedia

    2009-01-01

    Safety is an integral part of our working lives, and should be in our minds whatever job we do at CERN. Ultimately, safety is the responsibility of the Director General – your safety is my concern. That’s why I have this week appointed a new Safety Policy Committee (SAPOCO) that reflects the new Organizational structure of CERN. CERN’s Staff Rules and Regulations clearly lay out in chapter 3 the scope of safety at CERN as well as my responsibilities and yours in safety matters. At CERN, safety is considered in the broadest sense, encompassing occupational Health and Safety, environmental protection, and the safety of equipment and installations. It is my responsibility to put appropriate measures in place to ensure that these conditions are met. And it is the responsibility of us all to ensure that we are fully conversant with safety provisions applicable in our areas of work and that we comply with them. The appointment of a n...

  10. Superheroes in autoimmune warfare: Biologic therapies in current ...

    African Journals Online (AJOL)

    Biologic drugs targeting immune cells or cytokines underlying systemic inflammation have dramatically improved outcomes in patients with rheumatological and autoimmune diseases. Nine biologic drugs are currently available in South Africa (SA) – all showing good efficacy and safety profiles. Their high cost and potential ...

  11. Scientific Opinion on Risk Assessment of Synthetic Biology.

    Science.gov (United States)

    Epstein, Michelle M; Vermeire, Theo

    2016-08-01

    In 2013, three Scientific Committees of the European Commission (EC) drafted Scientific Opinions on synthetic biology that provide an operational definition and address risk assessment methodology, safety aspects, environmental risks, knowledge gaps, and research priorities. These Opinions contribute to the international discussions on the risk governance for synthetic biology developments. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Adapting to Biology: Maintaining Container-Closure System Compatibility with the Therapeutic Biologic Revolution.

    Science.gov (United States)

    Degrazio, Dominick

    Many pharmaceutical companies are transitioning their research and development drug product pipeline from traditional small-molecule injectables to the dimension of evolving therapeutic biologics. Important concerns associated with this changeover are becoming forefront, as challenges develop of varying complexity uncommon with the synthesis and production of traditional drugs. Therefore, alternative measures must be established that aim to preserve the efficacy and functionality of a biologic that might not be implemented for small molecules. Conserving protein stability is relative to perpetuating a net equilibrium of both intrinsic and extrinsic factors. Key to sustaining this balance is the ability of container-closure systems to maintain their compatibility with the ever-changing dynamics of therapeutic biologics. Failure to recognize and adjust the material properties of packaging components to support compatibility with therapeutic biologics can compromise patient safety, drug productivity, and biological stability. This review will examine the differences between small-molecule drugs and therapeutic biologics, lay a basic foundation for understanding the stability of therapeutic biologics, and demonstrate potential sources of container-closure systems' incompatibilities with therapeutic biologics at a mechanistic level. Many pharmaceutical companies are transitioning their research and development drug product pipeline from traditional small-molecule injectables to recombinantly derived therapeutic biologics. Concerns associated with this transformation are becoming prominent, as therapeutic biologics are uncharacteristic to small-molecule drugs. Maintaining the stability of a therapeutic biologic is a combination of balancing intrinsic factors and external elements within the biologic's microenvironment. An important aspect of this balance is relegated to the overall compatibility of primary, parenteral container-closure systems with therapeutic biologics

  13. TWRS safety program plan

    Energy Technology Data Exchange (ETDEWEB)

    Calderon, L.M., Westinghouse Hanford

    1996-08-01

    Management of Nuclear Safety, Industrial Safety, Industrial Hygiene, and Fire Protection programs, functions, and field support resources for Tank Waste Remediation Systems (TWRS) has, until recently, been centralized in TWRS Safety, under the Emergency, Safety, and Quality organization. Industrial hygiene technician services were also provided to support operational needs related to safety basis compliance. Due to WHC decentralization of safety and reengineering efforts in West Tank Farms, staffing and safety responsibilities have been transferred to the facilities. Under the new structure, safety personnel for TWRS are assigned directly to East Tank Farms, West Tank Farms, and a core Safety Group in TWRS Engineering. The Characterization Project Operations (CPO) safety organization will remain in tact as it currently exists. Personnel assigned to East Tank Farms, West Tank Farms, and CPO will perform facility-specific or project-specific duties and provide field implementation of programs. Those assigned to the core group will focus on activities having a TWRS-wide or programmatic focus. Hanford-wide activities will be the responsibility of the Safety Center of Expertise. In order to ensure an effective and consistent safety program for TWRS under the new organization program functions, goals, organizational structure, roles, responsibilities, and path forward must be clearly established. The purpose of the TWRS Safety Program Plan is to define the overall safety program, responsibilities, relationships, and communication linkages for safety personnel under the new structure. In addition, issues associated with reorganization transition are addressed, including training, project ownership, records management, and dissemination of equipment. For the purpose of this document ``TWRS Safety`` refers to all safety professionals and technicians (Industrial Safety, Industrial Hygiene, Fire Protection, and Nuclear Safety) within the TWRS organization, regardless of their

  14. Space station crew safety alternatives study. Volume 3: Safety impact of human factors

    Science.gov (United States)

    Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

    1985-01-01

    The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

  15. Scientific evidence contradicts findings and assumptions of Canadian Safety Panel 6: microwaves act through voltage-gated calcium channel activation to induce biological impacts at non-thermal levels, supporting a paradigm shift for microwave/lower frequency electromagnetic field action.

    Science.gov (United States)

    Pall, Martin L

    2015-01-01

    This review considers a paradigm shift on microwave electromagnetic field (EMF) action from only thermal effects to action via voltage-gated calcium channel (VGCC) activation. Microwave/lower frequency EMFs were shown in two dozen studies to act via VGCC activation because all effects studied were blocked by calcium channel blockers. This mode of action was further supported by hundreds of studies showing microwave changes in calcium fluxes and intracellular calcium [Ca2+]i signaling. The biophysical properties of VGCCs/similar channels make them particularly sensitive to low intensity, non-thermal EMF exposures. Non-thermal studies have shown that in most cases pulsed fields are more active than are non-pulsed fields and that exposures within certain intensity windows have much large biological effects than do either lower or higher intensity exposures; these are both consistent with a VGCC role but inconsistent with only a heating/thermal role. Downstream effects of VGCC activation include calcium signaling, elevated nitric oxide (NO), NO signaling, peroxynitrite, free radical formation, and oxidative stress. Downstream effects explain repeatedly reported biological responses to non-thermal exposures: oxidative stress; single and double strand breaks in cellular DNA; cancer; male and female infertility; lowered melatonin/sleep disruption; cardiac changes including tachycardia, arrhythmia, and sudden cardiac death; diverse neuropsychiatric effects including depression; and therapeutic effects. Non-VGCC non-thermal mechanisms may occur, but none have been shown to have effects in mammals. Biologically relevant safety standards can be developed through studies of cell lines/cell cultures with high levels of different VGCCs, measuring their responses to different EMF exposures. The 2014 Canadian Report by a panel of experts only recognizes thermal effects regarding safety standards for non-ionizing radiation exposures. Its position is therefore contradicted by each

  16. Nuclear law - Nuclear safety

    International Nuclear Information System (INIS)

    Pontier, Jean-Marie; Roux, Emmanuel; Leger, Marc; Deguergue, Maryse; Vallar, Christian; Pissaloux, Jean-Luc; Bernie-Boissard, Catherine; Thireau, Veronique; Takahashi, Nobuyuki; Spencer, Mary; Zhang, Li; Park, Kyun Sung; Artus, J.C.

    2012-01-01

    This book contains the contributions presented during a one-day seminar. The authors propose a framework for a legal approach to nuclear safety, a discussion of the 2009/71/EURATOM directive which establishes a European framework for nuclear safety in nuclear installations, a comment on nuclear safety and environmental governance, a discussion of the relationship between citizenship and nuclear, some thoughts about the Nuclear Safety Authority, an overview of the situation regarding the safety in nuclear waste burying, a comment on the Nome law with respect to electricity price and nuclear safety, a comment on the legal consequences of the Fukushima accident on nuclear safety in the Japanese law, a presentation of the USA nuclear regulation, an overview of nuclear safety in China, and a discussion of nuclear safety in the medical sector

  17. Occupational safety motivation

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2010-01-01

    Background: Motivation is one of the most important factors for safety behaviour and for implementing change in general. However, theoretical and psychometric studies of safety performance have traditionally treated safety motivation, safety compliance and safety participation unidimensionally....... At the same time many motivation questionnaire items are seldom founded on theory and/or do not account for the theories’ ontological and epistemological differences, e.g. of how knowledge, attitude and action are related. Present questionnaire items tap into occupational safety motivation in asking whether...... or not respondents ‘are’ motivated and whether they feel that safety is important or worthwhile. Another important aspect is ‘what’ motivates workers to comply to and participate in safety. The aim of this article is to introduce a new theory-based occupational safety motivation scale which is validated...

  18. Kankerrisico van biologicals vaststellen?

    DEFF Research Database (Denmark)

    Vermeer, Niels S; De Bruin, Marie L

    2013-01-01

    Safety meta-analyses could play an important role in capturing fragmented safety data from underpowered clinical studies. Their utility, however, is hampered by the same constraints surrounding clinical studies, including limited external validity, inconsistent classification and the underreporting...

  19. Kankerrisico van biologicals vaststellen?

    DEFF Research Database (Denmark)

    Vermeer, Niels S; De Bruin, Marie L

    2013-01-01

    Safety meta-analyses could play an important role in capturing fragmented safety data from underpowered clinical studies. Their utility, however, is hampered by the same constraints surrounding clinical studies, including limited external validity, inconsistent classification and the underreporti...

  20. Dyneins: structure, biology and disease

    National Research Council Canada - National Science Library

    King, Stephen M

    2012-01-01

    .... From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine...

  1. Learning Biology by Designing

    Science.gov (United States)

    Janssen, Fred; Waarlo, Arend Jan

    2010-01-01

    According to a century-old tradition in biological thinking, organisms can be considered as being optimally designed. In modern biology this idea still has great heuristic value. In evolutionary biology a so-called design heuristic has been formulated which provides guidance to researchers in the generation of knowledge about biological systems.…

  2. Biological conversion system

    Science.gov (United States)

    Scott, C.D.

    A system for bioconversion of organic material comprises a primary bioreactor column wherein a biological active agent (zymomonas mobilis) converts the organic material (sugar) to a product (alcohol), a rejuvenator column wherein the biological activity of said biological active agent is enhanced, and means for circulating said biological active agent between said primary bioreactor column and said rejuvenator column.

  3. [Biogeography: geography or biology?].

    Science.gov (United States)

    Kafanov, A I

    2009-01-01

    General biogeography is an interdisciplinary science, which combines geographic and biological aspects constituting two distinct research fields: biological geography and geographic biology. These fields differ in the nature of their objects of study, employ different methods and represent Earth sciences and biological sciences, respectively. It is suggested therefore that the classification codes for research fields and the state professional education standard should be revised.

  4. Adamkus lashes out at government, Cabinet

    Index Scriptorium Estoniae

    2005-01-01

    Leedu president Valdas Adamkus pidas 12. juulil kõne, milles avaldas rahulolematust parlamendi tööga. Presidendi sõnul on parlament sügavas kriisis ning selmet töötada Leedu riigi ja rahva hüvanguks tegeleb see vaid iseenda eksistentsi kindlustamisega

  5. 2506-IJBCS-Article-Djossou D Cabinet

    African Journals Online (AJOL)

    hp

    In some parts of Benin, like in many African countries, the fluorine rates contained in waters are higher than the rate recommended by the World Health Organization (WHO) (0.7-1.5 mg- /- L). Fluorine is useful against dental caries and makes the tooth enamel stronger. Nevertheless, at a higher concentration, it stains on.

  6. Modeling structural acoustic properties of loudspeaker cabinets

    DEFF Research Database (Denmark)

    Luan, Yu

    smearing technique for a cross-stiffened flat thin rectangular plate has been known for many years, but so far the accuracy of predicted natural frequencies has been inadequate. To improve predictions, all stiffeners including the ones neglected in the ordinary smearing technique are taken into account...... in the calculation of bending stiffness in this dissertation. The improved smearing technique results in good accuracy for predicted natural frequencies and forced vibrations of flat stiffened plates. Another improvement concerns the orientation of the stiffeners. The original smearing technique presupposes...... that the stiffeners are parallel to the edges of the plate, but simple considerations make it possible to relax this requirement. Whereas the improved smearing technique is well established for stiffened flat panels, there is no similar established technique for doubly curved stiffened shells. In an additional study...

  7. Performance of indirect solar cabinet dryer

    International Nuclear Information System (INIS)

    Sreekumar, A.; Manikantan, P.E.; Vijayakumar, K.P.

    2008-01-01

    In this paper, the development and testing of a new type of efficient solar dryer, particularly meant for drying vegetables and fruit, is described. The dryer has two compartments: one for collecting solar radiation and producing thermal energy and the other for spreading the product to be dried. This arrangement was made to absorb maximum solar radiation by the absorber plate. In this dryer, the product was loaded beneath the absorber plate, which prevented the problem of discoloration due to irradiation by direct sunlight. Two axial flow fans, provided in the air inlet, can accelerate the drying rate. The dryer had six perforated trays for loading the material. The absorber plate of the dryer attained a temperature of 97.2 deg. C when it was studied under no load conditions. The maximum air temperature in the dryer, under this condition was 78.1 deg. C. The dryer was loaded with 4 kg of bitter gourd having an initial moisture content of 95%, and the final desired moisture content of 5% was achieved within 6 h without losing the product colour, while it was 11 h for open sun drying. The collector glazing was inclined at a particular angle, suitable to the location, for absorption of maximum solar radiation. A detailed performance analysis was done by three methods, namely 'annualized cost method', 'present worth of annual savings' and 'present worth of cumulative savings'. The drying cost for 1 kg of bitter gourd was calculated as Rs. 17.52, and it was Rs. 41.35, in the case of an electric dryer. The life span of the solar dryer was assumed to be 20 years. The cumulative present worth of annual savings over the life of the solar dryer was calculated for bitter gourd drying, and it turned out be Rs. 31659.26, which was much higher than the capital cost of the dryer (Rs. 6500). The payback period was calculated as 3.26 years, which was also very small considering the life of the system (20 years). So, the dryer would dry products free of cost during almost its entire life span. The quality of the product dried in the solar dryer was competitive with the branded products available in the market

  8. ITER-FEAT safety

    International Nuclear Information System (INIS)

    Gordon, C.W.; Bartels, H.-W.; Honda, T.; Raeder, J.; Topilski, L.; Iseli, M.; Moshonas, K.; Taylor, N.; Gulden, W.; Kolbasov, B.; Inabe, T.; Tada, E.

    2001-01-01

    Safety has been an integral part of the design process for ITER since the Conceptual Design Activities of the project. The safety approach adopted in the ITER-FEAT design and the complementary assessments underway, to be documented in the Generic Site Safety Report (GSSR), are expected to help demonstrate the attractiveness of fusion and thereby set a good precedent for future fusion power reactors. The assessments address ITER's radiological hazards taking into account fusion's favourable safety characteristics. The expectation that ITER will need regulatory approval has influenced the entire safety design and assessment approach. This paper summarises the ITER-FEAT safety approach and assessments underway. (author)

  9. Safety- barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2008-01-01

    trees and Bayesian networks is discussed. A simple method for quantification of safety-barrier diagrams is proposed. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk analysis with operational safety management.......Safety-barrier diagrams and the related so-called 'bow-tie' diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation of safety-barrier diagrams to other methods such as fault...

  10. Beyond safety accountability

    CERN Document Server

    Geller, E Scott

    2001-01-01

    Written in an easy-to-read conversational tone, Beyond Safety Accountability explains how to develop an organizational culture that encourages people to be accountable for their work practices and to embrace a higher sense of personal responsibility. The author begins by thoroughly explaining the difference between safety accountability and safety responsibility. He then examines the need of organizations to improve safety performance, discusses why such performance improvement can be achieved through a continuous safety process, as distinguished from a safety program, and provides the practic

  11. Nuclear Safety Culture

    International Nuclear Information System (INIS)

    2017-01-01

    Ethics is caring about people and Safety is caring that no physical harm comes to people.Therefore Safety is a type of Ethical Behavior. Culture: is The Way We Do Things Here.Safety Culture is mixture of organization traditions, values, attitudes and behaviors modeled by Its leaders and internalized by its members that serve to make nuclear safety the overriding priority. Safety Culture is that assembly of characteristics and attitudes in Organisations and individuals which established that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance

  12. Safety KPIs - Monitoring of safety performance

    Directory of Open Access Journals (Sweden)

    Andrej Lališ

    2014-09-01

    Full Text Available This paper aims to provide brief overview of aviation safety development focusing on modern trends represented by implementation of Safety Key Performance Indicators. Even though aviation is perceived as safe means of transport, it is still struggling with its complexity given by long-term growth and robustness which it has reached today. Thus nowadays safety issues are much more complex and harder to handle than ever before. We are more and more concerned about organizational factors and control mechanisms which have potential to further increase level of aviation safety. Within this paper we will not only introduce the concept of Key Performance Indicators in area of aviation safety as an efficient control mechanism, but also analyse available legislation and documentation. Finally we will propose complex set of indicators which could be applied to Czech Air Navigation Service Provider.

  13. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997.

  14. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January-December 1997

    International Nuclear Information System (INIS)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997

  15. Fundamental Safety Principles

    International Nuclear Information System (INIS)

    Abdelmalik, W.E.Y.

    2011-01-01

    This work presents a summary of the IAEA Safety Standards Series publication No. SF-1 entitled F UDAMENTAL Safety PRINCIPLES p ublished on 2006. This publication states the fundamental safety objective and ten associated safety principles, and briefly describes their intent and purposes. Safety measures and security measures have in common the aim of protecting human life and health and the environment. These safety principles are: 1) Responsibility for safety, 2) Role of the government, 3) Leadership and management for safety, 4) Justification of facilities and activities, 5) Optimization of protection, 6) Limitation of risks to individuals, 7) Protection of present and future generations, 8) Prevention of accidents, 9)Emergency preparedness and response and 10) Protective action to reduce existing or unregulated radiation risks. The safety principles concern the security of facilities and activities to the extent that they apply to measures that contribute to both safety and security. Safety measures and security measures must be designed and implemented in an integrated manner so that security measures do not compromise safety and safety measures do not compromise security.

  16. Multimegawatt Space Reactor Safety

    International Nuclear Information System (INIS)

    Stanley, M.L.

    1989-01-01

    The Multimegawatt (MMW) Space Reactor Project supports the Strategic Defense Initiative Office requirement to provide reliable, safe, cost-effective, electrical power in the MMW range. Specifically, power may be used for neutral particle beams, free electron lasers, electromagnetic launchers, and orbital transfer vehicles. This power plant technology may also apply to the electrical power required for other uses such as deep-space probes and planetary exploration. The Multimegawatt Space Reactor Project, the Thermionic Fuel Element Verification Program, and Centaurus Program all support the Multimegawatt Space Nuclear Power Program and form an important part of the US Department of Energy's (DOE's) space and defense power systems activities. A major objective of the MMW project is the development of a reference flight system design that provides the desired levels of public safety, health protection, and special nuclear material (SNM) protection when used during its designated missions. The safety requirements for the MMW project are a hierarchy of requirements that consist of safety requirements/regulations, a safety policy, general safety criteria, safety technical specifications, safety design specifications, and the system design. This paper describes the strategy and philosophy behind the development of the safety requirements imposed upon the MMW concept developers. The safety organization, safety policy, generic safety issues, general safety criteria, and the safety technical specifications are discussed

  17. Emerging Stem Cell Therapies: Treatment, Safety, and Biology

    Directory of Open Access Journals (Sweden)

    Joel Sng

    2012-01-01

    Full Text Available Stem cells are the fundamental building blocks of life and contribute to the genesis and development of all higher organisms. The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal conditions. Hematopoietic stem cell transplantation was the first example of a successful stem cell therapy and is widely utilized for treating various diseases including adult T-cell leukemia-lymphoma and multiple myeloma. The autologous transplantation of mesenchymal stem cells is increasingly employed to catalyze the repair of mesenchymal tissue and others, including the lung and heart, and utilized in treating various conditions such as stroke, multiple sclerosis, and diabetes. There is also increasing interest in the therapeutic potential of other adult stem cells such as neural, mammary, intestinal, inner ear, and testicular stem cells. The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies.

  18. Pharmacovigilance of biologicals : dynamics in post-approval safety learning

    NARCIS (Netherlands)

    Vermeer, N.S.

    2015-01-01

    Regulatory decisions to allow new drugs on the market by definition have to accept a certain level of uncertainty about the full benefit-risk balance. Pre-approval studies typically provide information on a limited number of patients over a relative short follow-up period, and handle strict

  19. Ensuring biological safety of drinking water at International Crops ...

    African Journals Online (AJOL)

    Potability of drinking water from various sources at the campus of International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Andhra Pradesh, India had been assessed for 17 years (1994 to 2010). All four sources of drinking water at ICRISAT, including Manjeera water (Municipal corporation ...

  20. National Patient Safety Foundation

    Science.gov (United States)

    ... News Member Testimonials Lifetime Members Stand Up for Patient Safety Welcome Stand Up Members Stand Up e-News ... PLS Webcast Archives Stand Up Templates and Logos Patient Safety Coalition Coalition Overview Coalition Member Roster Members-Only ...

  1. National Safety Council

    Science.gov (United States)

    ... Hygiene Compliance Ergonomics Safety Management Industry Specific Reference Datasheets, Checklists First Aid ANSI Standards Shop NSC Homepage ... Hygiene Compliance Ergonomics Safety Management Industry Specific Reference Datasheets, Checklists First Aid ANSI Standards Shop our online ...

  2. Security vs. Safety.

    Science.gov (United States)

    Sturgeon, Julie

    1999-01-01

    Provides administrative advice on how some safety experts have made college campuses safer and friendlier without breaking the budget. Tips on security and advice on safety management that encompasses the whole environment are highlighted. (GR)

  3. Water safety and drowning

    Science.gov (United States)

    ... among people of all ages. Learning and practicing water safety is important to prevent drowning accidents. ... Water safety tips for all ages include: Learn CPR . Never swim alone. Never dive into water unless ...

  4. Safety, risk and Harrisburg

    International Nuclear Information System (INIS)

    Titterton, E.

    1979-06-01

    The author discusses public attitudes to safety, industrial accidents and reactor accidents, in particular the accident at Three-Mile Island. Arguments in favour of nuclear power, including its relative safety, are presented

  5. Periodic safety analyses

    International Nuclear Information System (INIS)

    Gouffon, A.; Zermizoglou, R.

    1990-12-01

    The IAEA Safety Guide 50-SG-S8 devoted to 'Safety Aspects of Foundations of Nuclear Power Plants' indicates that operator of a NPP should establish a program for inspection of safe operation during construction, start-up and service life of the plant for obtaining data needed for estimating the life time of structures and components. At the same time the program should ensure that the safety margins are appropriate. Periodic safety analysis are an important part of the safety inspection program. Periodic safety reports is a method for testing the whole system or a part of the safety system following the precise criteria. Periodic safety analyses are not meant for qualification of the plant components. Separate analyses are devoted to: start-up, qualification of components and materials, and aging. All these analyses are described in this presentation. The last chapter describes the experience obtained for PWR-900 and PWR-1300 units from 1986-1989

  6. Flu Vaccine Safety Information

    Science.gov (United States)

    ... Types Seasonal Avian Swine Variant Pandemic Other Flu Vaccine Safety Information Questions & Answers Language: English (US) Español ... of flu vaccines monitored? Egg Allergy Are flu vaccines safe? Flu vaccines have good safety record. Hundreds ...

  7. Gun Safety (For Kids)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Gun Safety KidsHealth / For Kids / Gun Safety What's in ... from guns outside the home. If You Have Guns in Your Home If your parents keep guns ...

  8. Scuba Diving Safety

    Science.gov (United States)

    ... questions and provide help. If needed, they will direct you to the nearest hyperbaric chamber or appropriate ... staff Categories: Exercise and Fitness, Prevention and Wellness, Sports SafetyTags: safety September 1, 2000 Copyright © American Academy ...

  9. Spacecraft Fire Safety Demonstration

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the Spacecraft Fire Safety Demonstration project is to develop and conduct large-scale fire safety experiments on an International Space Station...

  10. Safety-barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2007-01-01

    Safety-barrier diagrams and the related so-called "bow-tie" diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation with other methods such as fault trees and Bayesian network...... analysis with operational safety management.......Safety-barrier diagrams and the related so-called "bow-tie" diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation with other methods such as fault trees and Bayesian networks...... are discussed. A simple method for quantification of safety-barrier diagrams is proposed, including situations where safety barriers depend on shared common elements. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk...

  11. General safety aspects

    International Nuclear Information System (INIS)

    1998-01-01

    In this part next aspects are described: (1) Priority to safety; (2) Financial and human resources;; (3) Human factor; (4) Operator's quality assurance system; (5) Safety assessment and Verification; (6) Radiation protection and (7) Emergency preparedness

  12. Fires and Food Safety

    Science.gov (United States)

    ... Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... JSR 286) Actions ${title} Loading... Fires and Food Safety Fire! Few words can strike such terror. Residential ...

  13. Swimming Pool Safety

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Safety & Prevention Immunizations All Around At Home At Play ... Español Text Size Email Print Share Swimming Pool Safety Page Content ​What is the best way to ...

  14. Motor Vehicle Safety

    Science.gov (United States)

    ... these crashes is one part of motor vehicle safety. Here are some things you can do to ... speed or drive aggressively Don't drive impaired Safety also involves being aware of others. Share the ...

  15. Nuclear Safety Review 1991

    International Nuclear Information System (INIS)

    1993-01-01

    A survey of IAEA activities in the field of nuclear safety with particular emphasis on the international cooperation in safety assessment of research reactors, early WWER type reactors is given. 12 tabs., 2 figs

  16. Electrical safety guidelines

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The Electrical Safety Guidelines prescribes the DOE safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety standards and guidance for DOE installations in order to affect a reduction or elimination of risks associated with the use of electrical energy. The objectives of these guidelines are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  17. Safety analysts training

    International Nuclear Information System (INIS)

    Bolton, P.

    2000-01-01

    The purpose of this task was to support ESH-3 in providing Airborne Release Fraction and Respirable Fraction training to safety analysts at LANL who perform accident analysis, hazard analysis, safety analysis, and/or risk assessments at nuclear facilities. The task included preparation of materials for and the conduct of two 3-day training courses covering the following topics: safety analysis process; calculation model; aerosol physic concepts for safety analysis; and overview of empirically derived airborne release fractions and respirable fractions

  18. Generic safety documentation model

    Energy Technology Data Exchange (ETDEWEB)

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ``core`` upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information.

  19. DOE handbook electrical safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  20. BN-1200 Safety Concept

    International Nuclear Information System (INIS)

    Ashurko, Y.

    2013-01-01

    Safety concept of the BN-1200 design: • Takes into account experience gained from the BR-5/10, BOR-60, BN-350, BN-600, BN-800 and requirements imposed to the 4th generation advanced reactors; • Provides maximal application of inherent safety features and passive safety systems. Such approach permits: • To excel in safety existing designs, in particular BN-800; • And to meet requirements of the 4th generation

  1. Generic safety documentation model

    International Nuclear Information System (INIS)

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ''core'' upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information

  2. HSE's safety assessment principles for criticality safety

    International Nuclear Information System (INIS)

    Simister, D N; Finnerty, M D; Warburton, S J; Thomas, E A; Macphail, M R

    2008-01-01

    The Health and Safety Executive (HSE) published its revised Safety Assessment Principles for Nuclear Facilities (SAPs) in December 2006. The SAPs are primarily intended for use by HSE's inspectors when judging the adequacy of safety cases for nuclear facilities. The revised SAPs relate to all aspects of safety in nuclear facilities including the technical discipline of criticality safety. The purpose of this paper is to set out for the benefit of a wider audience some of the thinking behind the final published words and to provide an insight into the development of UK regulatory guidance. The paper notes that it is HSE's intention that the Safety Assessment Principles should be viewed as a reflection of good practice in the context of interpreting primary legislation such as the requirements under site licence conditions for arrangements for producing an adequate safety case and for producing a suitable and sufficient risk assessment under the Ionising Radiations Regulations 1999 (SI1999/3232 www.opsi.gov.uk/si/si1999/uksi_19993232_en.pdf). (memorandum)

  3. General safety considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness.

  4. General safety considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness.

  5. Safety-barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2007-01-01

    are discussed. A simple method for quantification of safety-barrier diagrams is proposed, including situations where safety barriers depend on shared common elements. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk...

  6. Safety-in-numbers

    DEFF Research Database (Denmark)

    Elvik, Rune; Bjørnskau, Torkel

    2017-01-01

    Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....

  7. General safety considerations

    International Nuclear Information System (INIS)

    2001-01-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness

  8. Radiation protection and the safety of radiation sources

    International Nuclear Information System (INIS)

    1996-01-01

    These Safety Fundamentals cover the protection of human beings against ionizing radiation (gamma and X rays and alpha, beta and other particles that can induce ionization as they interact with biological materials), referred to herein subsequently as radiation, and the safety of sources that produce ionizing radiation. The Fundamentals do not apply to non-ionizing radiation such as microwave, ultraviolet, visible and infrared radiation. They do not apply either to the control of non-radiological aspects of health and safety. They are, however, part of the overall framework of health and safety

  9. Leadership and safety culture. Leadership for safety

    International Nuclear Information System (INIS)

    Fischer, Erwin; Nithack, Eckhard

    2016-01-01

    The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

  10. Leadership and safety culture. Leadership for safety

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erwin; Nithack, Eckhard [PreussenElektra GmbH, Hannover (Germany)

    2016-08-15

    The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

  11. Safety culture : a significant influence on safety in transportation

    Science.gov (United States)

    2017-08-01

    An organizations safety culture can influence safety outcomes. Research and experience show that when safety culture is strong, accidents are less frequent and less severe. As a result, building and maintaining strong safety cultures should be a t...

  12. Nuclear Safety Review 2013

    International Nuclear Information System (INIS)

    2013-07-01

    The Nuclear Safety Review 2013 focuses on the dominant nuclear safety trends, issues and challenges in 2012. The Executive Overview provides crosscutting and worldwide nuclear safety information along with a summary of the major sections covered in this report. Sections A-E of this report cover improving radiation, transport and waste safety; strengthening safety in nuclear installations; improving regulatory infrastructure and effectiveness; enhancing emergency preparedness and response (EPR); and civil liability for nuclear damage. The Appendix provides details on the activities of the Commission on Safety Standards (CSS), and activities relevant to the IAEA Safety Standards. The world nuclear community has made noteworthy progress in strengthening nuclear safety in 2012, as promoted by the IAEA Action Plan on Nuclear Safety (hereinafter referred to as ''the Action Plan''). For example, an overwhelming majority of Member States with operating nuclear power plants (NPPs) have undertaken and essentially completed comprehensive safety reassessments ('stress tests') with the aim of evaluating the design and safety aspects of plant robustness to protect against extreme events, including: defence in depth, safety margins, cliff edge effects, multiple failures, and the prolonged loss of support systems. As a result, many have introduced additional safety measures including mitigation of station blackout. Moreover, the IAEA's peer review services and safety standards have been reviewed and strengthened where needed. Capacity building programmes have been built or improved, and EPR programmes have also been reviewed and improved. Furthermore, in 2012, the IAEA continued to share lessons learned from the Fukushima Daiichi accident with the nuclear community including through three international experts' meetings (IEMs) on reactor and spent fuel safety, communication in the event of a nuclear or radiological emergency, and protection against extreme earthquakes and tsunamis

  13. EFSA Panel on Biological Hazards (BIOHAZ); Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2011 update)

    DEFF Research Database (Denmark)

    Hald, Tine

    ) assessment was developed by EFSA for its own use to provide a generic risk assessment approach applicable across EFSA’s scientific Panels, for biological agents notified for intentional use in the whole food chain. The safety of unambiguously defined biological agents at the highest taxonomic unit......EFSA is requested to assess the safety of a broad range of biological agents (including microorganisms and viruses) in the context of notifications for market authorisation as sources of food and feed additives, enzymes and plant protection products. The qualified presumption of safety (QPS...

  14. Nuclear safety in perspective

    DEFF Research Database (Denmark)

    Andersson, K.; Sjöberg, B.M.D.; Lauridsen, Kurt

    2003-01-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicat-ing on the subject in society. The project, which has been built around a number of seminars, wassupported by limited research in three sub......-projects: Risk assessment Safety analysis Strategies for safety management The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems forregulatory oversight are de-scribed in the nuclear area and also, to widen the perspective, for other...

  15. Safety in Cryogenics – Safety device sizing

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The calculation is separated in three operations: o The estimation of the loads arriving on the component to protect, o The calculation of the mass flow to evacuate, o And the sizing of the safety device.

  16. Uncertain safety: allocating responsibilities for safety

    National Research Council Canada - National Science Library

    2009-01-01

    Flood prevention, food safety, the transport of hazardous substances, infectious diseases, the risk of new Technologies and many other threats to public health and the environment call for ongoing public alertness...

  17. Advances in Biological Science.

    Science.gov (United States)

    Oppenheimer, Steven B.; And Others

    1988-01-01

    Reviews major developments in areas that are at the cutting edge of biological research. Areas include: human anti-cancer gene, recombinant DNA techniques for the detection of Huntington disease carriers, and marine biology. (CW)

  18. Biological basis of detoxication

    National Research Council Canada - National Science Library

    Caldwell, John; Jakoby, William B

    1983-01-01

    This volume considers that premise that most of the major patterns of biological conversion of foreign compounds are known and may have predictive value in assessing the biological course for novel compounds...

  19. Biology of Blood

    Science.gov (United States)

    ... switch to the Professional version Home Blood Disorders Biology of Blood Overview of Blood Resources In This ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  20. Safety system function trends

    International Nuclear Information System (INIS)

    Johnson, C.

    1989-01-01

    This paper describes research to develop risk-based indicators of plant safety performance. One measure of the safety-performance of operating nuclear power plants is the unavailability of important safety systems. Brookhaven National Laboratory and Science Applications International Corporation are evaluating ways to aggregate train-level or component-level data to provide such an indicator. This type of indicator would respond to changes in plant safety margins faster than the currently used indicator of safety system unavailability (i.e., safety system failures reported in licensee event reports). Trends in the proposed indicator would be one indication of trends in plant safety performance and maintenance effectiveness. This paper summarizes the basis for such an indicator, identifies technical issues to be resolved, and illustrates the potential usefullness of such indicators by means of computer simulations and case studies

  1. Patient Safety Culture

    DEFF Research Database (Denmark)

    Kristensen, Solvejg

    Patient safety is highly prioritised in the Danish health care system, never the less, patients are still exposed to risk and harmed every day. Implementation of a patient safety culture has been suggested an effective mean to protect patients against adverse events. Working strategically...... with assessment and development of the patient safety culture is in early days in Denmark. It depends upon valid, reliable and effective methods. The patient safety culture represents a wide range of social phenomena permeating the way of life in a health care. In essence, the safety culture is an aggregation...... of health care professional’s behaviour, habits, norms, values, and basic assumptions related to patient care; it is the way things are done. The patient safety culture guides the motivation, commitment to and know-how of the safety management, and how all members of a work place interact. This thesis...

  2. Optimization of safety equipment outages improves safety

    International Nuclear Information System (INIS)

    Cepin, Marko

    2002-01-01

    Testing and maintenance activities of safety equipment in nuclear power plants are an important potential for risk and cost reduction. An optimization method is presented based on the simulated annealing algorithm. The method determines the optimal schedule of safety equipment outages due to testing and maintenance based on minimization of selected risk measure. The mean value of the selected time dependent risk measure represents the objective function of the optimization. The time dependent function of the selected risk measure is obtained from probabilistic safety assessment, i.e. the fault tree analysis at the system level and the fault tree/event tree analysis at the plant level, both extended with inclusion of time requirements. Results of several examples showed that it is possible to reduce risk by application of the proposed method. Because of large uncertainties in the probabilistic safety assessment, the most important result of the method may not be a selection of the most suitable schedule of safety equipment outages among those, which results in similarly low risk. But, it may be a prevention of such schedules of safety equipment outages, which result in high risk. Such finding increases the importance of evaluation speed versus the requirement of getting always the global optimum no matter if it is only slightly better that certain local one

  3. Biological Races in Humans

    OpenAIRE

    Templeton, Alan R.

    2013-01-01

    Races may exist in humans in a cultural sense, but biological concepts of race are needed to access their reality in a non-species-specific manner and to see if cultural categories correspond to biological categories within humans. Modern biological concepts of race can be implemented objectively with molecular genetic data through hypothesis-testing. Genetic data sets are used to see if biological races exist in humans and in our closest evolutionary relative, the chimpanzee. Using the two m...

  4. Biological Age Predictors

    OpenAIRE

    Jylh?v?, Juulia; Pedersen, Nancy L.; H?gg, Sara

    2017-01-01

    The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate biomarkers that may be considered as biological age predictors. In this review, we summarize current state-of-the-art findings considering six potential types of biological age predictors: epigenetic clocks, telomere length, transcr...

  5. Safety class methodology

    International Nuclear Information System (INIS)

    Donner, E.B.; Low, J.M.; Lux, C.R.

    1992-01-01

    DOE Order 6430.1A, General Design Criteria (GDC), requires that DOE facilities be evaluated with respect to ''safety class items.'' Although the GDC defines safety class items, it does not provide a methodology for selecting safety class items. The methodology described in this paper was developed to assure that Safety Class Items at the Savannah River Site (SRS) are selected in a consistent and technically defensible manner. Safety class items are those in the highest of four categories determined to be of special importance to nuclear safety and, merit appropriately higher-quality design, fabrication, and industrial test standards and codes. The identification of safety class items is approached using a cascading strategy that begins at the 'safety function' level (i.e., a cooling function, ventilation function, etc.) and proceeds down to the system, component, or structure level. Thus, the items that are required to support a safety function are SCls. The basic steps in this procedure apply to the determination of SCls for both new project activities, and for operating facilities. The GDC lists six characteristics of SCls to be considered as a starting point for safety item classification. They are as follows: 1. Those items whose failure would produce exposure consequences that would exceed the guidelines in Section 1300-1.4, ''Guidance on Limiting Exposure of the Public,'' at the site boundary or nearest point of public access 2. Those items required to maintain operating parameters within the safety limits specified in the Operational Safety Requirements during normal operations and anticipated operational occurrences. 3. Those items required for nuclear criticality safety. 4. Those items required to monitor the release of radioactive material to the environment during and after a Design Basis Accident. Those items required to achieve, and maintain the facility in a safe shutdown condition 6. Those items that control Safety Class Item listed above

  6. Biological Water or Rather Water in Biology?

    Czech Academy of Sciences Publication Activity Database

    Jungwirth, Pavel

    2015-01-01

    Roč. 6, č. 13 (2015), s. 2449-2451 ISSN 1948-7185 Institutional support: RVO:61388963 Keywords : biological water * protein * interface Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 8.539, year: 2015

  7. Evolutionary Biology Today

    Indian Academy of Sciences (India)

    Evolutionary Biology Today - The Domain of Evolutionary Biology ... Keywords. Evolution; natural selection; biodiversity; fitness; adaptation. Author Affiliations. Amitabh Joshi1. Evolutionary and Organismal Biology Unit Jawaharlal Nehru Centre for Advanced Scientific Research P.Box 6436, Jakkur Bangalore 560 065, India.

  8. Biology Myth-Killers

    Science.gov (United States)

    Lampert, Evan

    2014-01-01

    "Biology Myth-Killers" is an activity designed to identify and correct common misconceptions for high school and college introductory biology courses. Students identify common myths, which double as biology misconceptions, and use appropriate sources to share the "truth" about the myths. This learner-centered activity is a fun…

  9. Designing synthetic biology.

    Science.gov (United States)

    Agapakis, Christina M

    2014-03-21

    Synthetic biology is frequently defined as the application of engineering design principles to biology. Such principles are intended to streamline the practice of biological engineering, to shorten the time required to design, build, and test synthetic gene networks. This streamlining of iterative design cycles can facilitate the future construction of biological systems for a range of applications in the production of fuels, foods, materials, and medicines. The promise of these potential applications as well as the emphasis on design has prompted critical reflection on synthetic biology from design theorists and practicing designers from many fields, who can bring valuable perspectives to the discipline. While interdisciplinary connections between biologists and engineers have built synthetic biology via the science and the technology of biology, interdisciplinary collaboration with artists, designers, and social theorists can provide insight on the connections between technology and society. Such collaborations can open up new avenues and new principles for research and design, as well as shed new light on the challenging context-dependence-both biological and social-that face living technologies at many scales. This review is inspired by the session titled "Design and Synthetic Biology: Connecting People and Technology" at Synthetic Biology 6.0 and covers a range of literature on design practice in synthetic biology and beyond. Critical engagement with how design is used to shape the discipline opens up new possibilities for how we might design the future of synthetic biology.

  10. Biological Therapies for Cancer

    Science.gov (United States)

    ... Page What is biological therapy? What is the immune system and what role does it have in biological therapy for cancer? ... trials (research studies involving people). What is the immune system and what role does it have in biological therapy for cancer? ...

  11. Testing safety commitment in organizations through interpretations of safety artifacts.

    Science.gov (United States)

    Luria, Gil; Rafaeli, Anat

    2008-01-01

    Safety culture relates to injuries and safety incidents in organizations, but is difficult to asses and measure. We describe a preliminary test of assessing an organization's safety culture by examining employee interpretations of organizational safety artifacts (safety signs). We collected data in three organizations using a new safety culture assessment tool that we label the Safety Artifact Interpretation (SAI) scale; we then crossed these data with safety climate and leadership evaluations. SAI were interpreted by employees in accordance with two conceptually distinct themes that are salient in the literature on organizational safety culture: safety compliance and commitment to safety. A significant correlation exists between SAI scores and the organizational safety climate. A similar (though insignificant) relationship was observed between SAI scores and leadership ratings. Employee perceptions and interpretations of safety artifacts can facilitate assessments of safety culture and can ultimately lead to understanding of and improvements in the level of organizational safety.

  12. Responding to a biological incident

    Energy Technology Data Exchange (ETDEWEB)

    Campagna, P.R. [U.S. Environmental Response Team, Office of Superfund Remediation and Technology Innovation, Edison, NJ (United States)

    2005-07-01

    The U.S. Environmental Protection Agency's Environmental Response Team (ERT) was established in October 1978 to provide technical assistance to a variety of governmental agencies in the area of environmental emergency issues such as chemical spills, uncontrolled hazardous waste site and terrorist incidents. This paper describes responses to a biological incident that occurred on July 29 2004, when the United States Department of Agriculture (USDA) received an anonymous e-mail identifying 3 containers on board the M/V Rio Puelo, one of which was said to contain a harmful biological substance. The containers were part of a 5 container shipment of Argentinian lemons bound for Canada. The vessel had a total of 2204 containers, of which 260 were loaded at the same port as the lemons. The containers were to be off-loaded at the Port of Newark and transported via truck to Canada. The federal On-Scene Coordinator (OSC) was responsible for managing this incident, as well as assessing the creditability of the threat. In accordance with federal authorities under the Public Water Safety Act, the Captain of the Port of New York ordered the vessel to anchor off shore. A tactical security operations team was dispatched to assess vessel security. It was determined that none of the crew, who had been exposed to the potential agent 10 days earlier, had shown any symptoms of biological warfare agents. A multi-agency unified command was set up, consisting of state, federal and local agencies. Various options were evaluated, including treatment of the containers on board due to the possibility of a dispersal device which could cause wide-spread contamination; the off loading and disposal of the cargo into the sea; and off loading of containers on shore with subsequent treatment. The following safety precautions were taken: cooling units were shut off 48 hours before sailing; the vents were sealed and closed; and the drains were plugged. At the port, trained dogs were used, and

  13. Central Safety Department. Annual report 1986

    International Nuclear Information System (INIS)

    Kiefer, H.; Koenig, L.A.

    1987-03-01

    The Safety Officer and the Security Officer are responsible for radiation protection and technical safety, both conventional and nuclear, for the physical protection as well as the safeguards of nuclear materials and radioactive substances within the Kernforschungszentrum Karlsruhe GmbH (KfK). To fulfill these functions they rely on the assistance of the Central Safety Department. The Central Safety Department is responsible for handling all problems of radiation protection, safety and security of the institutes and departments of the Karlsruhe Nuclear Research Center, for waste water activity measurements and environmental monitoring of the whole area of the Center, and for research and development work mainly focusing on nuclear safety and radiation protection measures. The r+d work concentrates on the following aspects: physical and chemical behavior of biologically particularly active radionuclides, behavior of HT in the air/plant/soil system, biophysics of multicellular systems, improvement in radiation protection measurement and personnel dosimetry. The report gives details of the different duties, indicates the results of 1986 routine tasks and reports about results of investigations and developments of the working groups of the Department. (orig.) [de

  14. Can -omics inform a food safety assessment?

    Science.gov (United States)

    Chassy, Bruce M

    2010-12-01

    Omic technologies can in principle allow visualization of the all of changes that take place when the genetics, nutrition or environment of an organism is altered. Targeted compositional analysis is today a key component of the food safety assessment paradigm in which known nutrients, anti-nutrients, toxicants, allergens, and other molecules of potential biological importance to humans or animals are quantitatively analyzed. This allows safety assessors to compare the composition and safety of one food with closely related counterparts. Omic technologies measure many analytes-some of which are unidentified-but the analysis often sacrifices one or more of the characteristics of validated analytical methods currently used for food analysis. Databases that would allow the safety assessor to interpret differences are not currently available. There is also no reason to believe that the targeted compositional analysis in use today does not provide the evidence needed to ensure food safety, nor is there any current reason to believe that omics can add value to the safety assessment process. The regulation of transgenic crops is far more rigorous than is justified since they present no new risks compared with traditional breeding, and are more precisely defined and better understood than their non-transgenic equivalent. Copyright © 2010 Elsevier Inc. All rights reserved.

  15. Biological protection against nuclear radiation

    International Nuclear Information System (INIS)

    Mateescu, Silvia; Stanciu, Marcela

    2001-01-01

    the non-homogeneities in biological shields at nuclear reactors and several methods for calculating non-homogeneous shields are presented. Chapter 10 describes the principal materials used as biological shielding against nuclear radiations, such as steel, lead, light water, concrete, etc. as well as, their behaviour in radiation fields. In the chapter 11 several examples of evaluating the dose rates and designing biological shieldings are given. Finally, chapter 12 gives definition of nuclear safety, events and nuclear accidents. Here also aspects of the Chernobyl accident are presented. Six appendices are added containing data of general use such as level and decay schemes, attenuation coefficients, data referring to U-235 fission products, etc. The work represents a compact and coherent synthesis of the main shielding calculation methods offering at the same time the necessary numerical data. An up-date comprehensive reference list completes this monograph

  16. Resolving conflicting safety cultures

    International Nuclear Information System (INIS)

    Slider, J.E.; Patterson, M.

    1993-01-01

    Several nuclear power plant sites have been wounded in the crossfire between two distinct corporate cultures. The traditional utility culture lies on one side and that of the nuclear navy on the other. The two corporate cultures lead to different perceptions of open-quotes safety culture.close quotes This clash of safety cultures obscures a very important point about nuclear plant operations: Safety depends on organizational learning. Organizational learning provides the foundation for a perception of safety culture that transcends the conflict between utility and nuclear navy cultures. Corporate culture may be defined as the knowledge, attitudes, and beliefs shared by employees of a given company. Safety culture is the part of corporate culture concerning shared attitudes and beliefs affecting individual or public safety. If the safety culture promotes behaviors that lead to greater safety, employees will tend to open-quotes do the right thingclose quotes even when circumstances and formal guidance alone do not ensure that actions will be correct. Safety culture has become particularly important to nuclear plant owners and regulators as they have sought to establish and maintain a high level of safety in today's plants

  17. Management of safety culture

    International Nuclear Information System (INIS)

    Kavsek, D.

    2004-01-01

    The strengthening of safety culture in an organization has become an increasingly important issue for nuclear industry. A high level of safety performance is essential for business success in intensely competitive global environment. This presentation offers a discussion of some principles and activities used in enhancing safety performance and appropriate safety behaviour at the Krsko NPP. Over the years a number of events have occurred in nuclear industry that have involved problems in human performance. A review of these and other significant events has identified recurring weaknesses in plant safety culture and policy. Focusing attention on the strengthening of relevant processes can help plants avoid similar undesirable events. The policy of the Krsko NPP is that all employees concerned shall constantly be alert to opportunities to reduce risks to the lowest practicable level and to achieve excellence in plant safety. The most important objective is to protect individuals, society and the environment by establishing and maintaining an effective defense against radiological hazard in the nuclear power plant. It is achieved through the use of reliable structures, components, systems, and procedures, as well as plant personnel committed to a strong safety culture. The elements of safety culture include both organizational and individual aspects. Elements commonly included at the organizational level are senior management commitment to safety, organizational effectiveness, effective communication, organizational learning, and a culture that encourages identification and resolution of safety issues. Elements identified at the individual level include personal accountability, a questioning attitude, communication, procedural adherence, etc.(author)

  18. Synthetic biological networks

    International Nuclear Information System (INIS)

    Archer, Eric; Süel, Gürol M

    2013-01-01

    Despite their obvious relationship and overlap, the field of physics is blessed with many insightful laws, while such laws are sadly absent in biology. Here we aim to discuss how the rise of a more recent field known as synthetic biology may allow us to more directly test hypotheses regarding the possible design principles of natural biological networks and systems. In particular, this review focuses on synthetic gene regulatory networks engineered to perform specific functions or exhibit particular dynamic behaviors. Advances in synthetic biology may set the stage to uncover the relationship of potential biological principles to those developed in physics. (review article)

  19. Biological Control in Agroecosystems

    Science.gov (United States)

    Batra, Suzanne W. T.

    1982-01-01

    Living organisms are used as biological pest control agents in (i) classical biological control, primarily for permanent control of introduced perennial weed pests or introduced pests of perennial crops; (ii) augmentative biological control, for temporary control of native or introduced pests of annual crops grown in monoculture; and (iii) conservative or natural control, in which the agroecosystem is managed to maximize the effect of native or introduced biological control agents. The effectiveness of biological control can be improved if it is based on adequate ecological information and theory, and if it is integrated with other pest management practices.

  20. Safety study application guide

    International Nuclear Information System (INIS)

    1993-07-01

    Martin Marietta Energy Systems, Inc., (Energy Systems) is committed to performing and documenting safety analyses for facilities it manages for the Department of Energy (DOE). Included are analyses of existing facilities done under the aegis of the Safety Analysis Report Upgrade Program, and analyses of new and modified facilities. A graded approach is used wherein the level of analysis and documentation for each facility is commensurate with the magnitude of the hazard(s), the complexity of the facility and the stage of the facility life cycle. Safety analysis reports (SARs) for hazard Category 1 and 2 facilities are usually detailed and extensive because these categories are associated with public health and safety risk. SARs for Category 3 are normally much less extensive because the risk to public health and safety is slight. At Energy Systems, safety studies are the name given to SARs for Category 3 (formerly open-quotes lowclose quotes) facilities. Safety studies are the appropriate instrument when on-site risks are limited to irreversible consequences to a few people, and off-site consequences are limited to reversible consequences to a few people. This application guide provides detailed instructions for performing safety studies that meet the requirements of DOE Orders 5480.22, open-quotes Technical Safety Requirements,close quotes and 5480.23, open-quotes Nuclear Safety Analysis Reports.close quotes A seven-chapter format has been adopted for safety studies. This format allows for discussion of all the items required by DOE Order 5480.23 and for the discussions to be readily traceable to the listing in the order. The chapter titles are: (1) Introduction and Summary, (2) Site, (3) Facility Description, (4) Safety Basis, (5) Hazardous Material Management, (6) Management, Organization, and Institutional Safety Provisions, and (7) Accident Analysis

  1. Leadership and Safety Culture: Leadership for Safety

    International Nuclear Information System (INIS)

    Fischer, E.

    2016-01-01

    Following the challenge to operate Nuclear Power Plants towards operational excellence, a highly skilled and motivated organization is needed. Therefore, leadership is a valuable success factor. On the other hand a well-engineered safety orientated design of NPP’s is necessary. Once built, an NPP constantly requires maintenance, ageing management and lifetime modifications. E.ON tries to keep the nuclear units as close as possible to the state of the art of science and technology. Not at least a requirement followed by our German regulation. As a consequence of this we are continuously challenged to improve our units and the working processes using national and international operational experiences too. A lot of modifications are driven by our self and by regulators. That why these institutions — authorities and independent examiners—contribute significantly to the safety success. Not that it is easy all the day. The relationship between the regulatory body, examiners and the utilities should be challenging but also cooperative and trustful within a permanent dialog. To reach the common goal of highest standards regarding nuclear safety all parties have to secure a living safety culture. Without this attitude there is a higher risk that safety relevant aspects may stay undetected and room for improvement is not used. Nuclear operators should always be sensitized and follow each single deviation. Leaders in an NPP-organization are challenged to create a safety-, working-, and performance culture based on clear common values and behaviours, repeated and lived along all of our days to create a least a strong identity in the staffs mind to the value of safety, common culture and overall performance. (author)

  2. Traceability of Software Safety Requirements in Legacy Safety Critical Systems

    Science.gov (United States)

    Hill, Janice L.

    2007-01-01

    How can traceability of software safety requirements be created for legacy safety critical systems? Requirements in safety standards are imposed most times during contract negotiations. On the other hand, there are instances where safety standards are levied on legacy safety critical systems, some of which may be considered for reuse for new applications. Safety standards often specify that software development documentation include process-oriented and technical safety requirements, and also require that system and software safety analyses are performed supporting technical safety requirements implementation. So what can be done if the requisite documents for establishing and maintaining safety requirements traceability are not available?

  3. Quantum biological information theory

    CERN Document Server

    Djordjevic, Ivan B

    2016-01-01

    This book is a self-contained, tutorial-based introduction to quantum information theory and quantum biology. It serves as a single-source reference to the topic for researchers in bioengineering, communications engineering, electrical engineering, applied mathematics, biology, computer science, and physics. The book provides all the essential principles of the quantum biological information theory required to describe the quantum information transfer from DNA to proteins, the sources of genetic noise and genetic errors as well as their effects. Integrates quantum information and quantum biology concepts; Assumes only knowledge of basic concepts of vector algebra at undergraduate level; Provides a thorough introduction to basic concepts of quantum information processing, quantum information theory, and quantum biology; Includes in-depth discussion of the quantum biological channel modelling, quantum biological channel capacity calculation, quantum models of aging, quantum models of evolution, quantum models o...

  4. Formal Safety versus Real Safety: Quantitative and Qualitative Approaches to Safety Culture – Evidence from Estonia

    Directory of Open Access Journals (Sweden)

    Järvis Marina

    2016-10-01

    Full Text Available This paper examines differences between formal safety and real safety in Estonian small and medium-sized enterprises. The results reveal key issues in safety culture assessment. Statistical analysis of safety culture questionnaires showed many organisations with an outstanding safety culture and positive safety attitudes. However, qualitative data indicated some important safety weaknesses and aspects that should be included in the process of evaluation of safety culture in organisations.

  5. A Holistic Approach to Protection and Safety

    International Nuclear Information System (INIS)

    Yankovich, L.T.

    2017-01-01

    Natural Ecosystems Undergo Inherent Fluctuations and Changes that are Related to Physical, Geological, Biological and other Natural Processes Associated with the Cycles of Life and the Earth. In other words, the effects of human activities must be evaluated in the context of the 'baseline' processes that are inherent to and imposed on natural ecosystems. The IAEA has established ahierarchy of Safety Standards, consisting of a set of ''Safety Fundamentals'' at the highest level, followed by ''Requirements'', then recommendations or ''guidance''. Human activities involving the use of radiation and radioactive substances can cause radiation exposure to people and the environment. This exposure should be regulated and monitored in accordance with international safety standards and national legislation

  6. Safety advice sheets

    CERN Multimedia

    HSE Unit

    2013-01-01

    You never know when you might be faced with questions such as: when/how should I dispose of a gas canister? Where can I find an inspection report? How should I handle/store/dispose of a chemical substance…?   The SI section of the DGS/SEE Group is primarily responsible for safety inspections, evaluating the safety conditions of equipment items, premises and facilities. On top of this core task, it also regularly issues “Safety Advice Sheets” on various topics, designed to be of assistance to users but also to recall and reinforce safety rules and procedures. These clear and concise sheets, complete with illustrations, are easy to display in the appropriate areas. The following safety advice sheets have been issued so far: Other sheets will be published shortly. Suggestions are welcome and should be sent to the SI section of the DGS/SEE Group. Please send enquiries to general-safety-visits.service@cern.ch.

  7. Reliability and safety engineering

    CERN Document Server

    Verma, Ajit Kumar; Karanki, Durga Rao

    2016-01-01

    Reliability and safety are core issues that must be addressed throughout the life cycle of engineering systems. Reliability and Safety Engineering presents an overview of the basic concepts, together with simple and practical illustrations. The authors present reliability terminology in various engineering fields, viz.,electronics engineering, software engineering, mechanical engineering, structural engineering and power systems engineering. The book describes the latest applications in the area of probabilistic safety assessment, such as technical specification optimization, risk monitoring and risk informed in-service inspection. Reliability and safety studies must, inevitably, deal with uncertainty, so the book includes uncertainty propagation methods: Monte Carlo simulation, fuzzy arithmetic, Dempster-Shafer theory and probability bounds. Reliability and Safety Engineering also highlights advances in system reliability and safety assessment including dynamic system modeling and uncertainty management. Cas...

  8. Nuclear power safety

    International Nuclear Information System (INIS)

    1988-01-01

    The International Atomic Energy Agency, the organization concerned with worldwide nuclear safety has produced two international conventions to provide (1) prompt notification of nuclear accidents and (2) procedures to facilitate mutual assistance during an emergency. IAEA has also expanded operational safety review team missions, enhanced information exchange on operational safety events at nuclear power plants, and planned a review of its nuclear safety standards to ensure that they include the lessons learned from the Chernobyl nuclear plant accident. However, there appears to be a nearly unanimous belief among IAEA members that may attempt to impose international safety standards verified by an international inspection program would infringe on national sovereignty. Although several Western European countries have proposed establishing binding safety standards and inspections, no specific plant have been made; IAEA's member states are unlikely to adopt such standards and an inspection program

  9. Safety objectives for 2014

    CERN Multimedia

    HSE Unit

    2014-01-01

    This is the third year in which the CERN Management has presented annual safety objectives for the Organization, the “HSE Objectives”.   The HSE objectives for 2014, which were announced by the Director-General at his traditional New Year’s address to the staff and were presented at the first Enlarged Directorate meeting of the year, have been drawn up and agreed in close collaboration between the DSOs, the HSE Unit and the DG himself. From safety in the workplace to radiation and environmental protection, the document emphasises that “Safety is a priority for CERN” and that safety policy is a key element in how the Organization is run. And, like all policies, it generates objectives that “serve as a general framework for action”. The HSE objectives are broken down into the following fields: occupational health and safety on sites and in the workplace, radiation protection, radiation safety, environmental protection, emerge...

  10. LMFBR operational safety

    International Nuclear Information System (INIS)

    Sackett, J.I.; Allen, N.L.; Dean, E.M.; Fryer, R.M.; Larson, H.A.; Lehto, W.K.

    1978-01-01

    The mission of the Experimental Breeder Reactor II (EBR-II) has envolved from that of a small LMFBR demonstration plant to a major irradiation-test facility. Because of that evolution, many operational-safety issues have been encountered. This paper describes the EBR-II operational-safety experience in four areas: protection-system design, safety-document preparation, tests of off-normal reactor conditions, and tests of elements with breached cladding. (author)

  11. Nuclear Safety in Europe

    International Nuclear Information System (INIS)

    Birkhofer, A.

    1994-01-01

    The situation of nuclear safety in Western and Eastern Europe is described, focusing on the French and German approaches. The paper starts with an overview of the historical development and proceeds with recent trends in monitoring and improving the safety status of current plants, the approach to accident management, and the objectives of the development of future reactor concepts. Furthermore, important problems of nuclear safety in Central and Eastern Europe are discussed. 1 fig

  12. Principles of electrical safety

    CERN Document Server

    Sutherland, Peter E

    2015-01-01

    Principles of Electrical Safety discusses current issues in electrical safety, which are accompanied by series' of practical applications that can be used by practicing professionals, graduate students, and researchers. .  Provides extensive introductions to important topics in electrical safety Comprehensive overview of inductance, resistance, and capacitance as applied to the human body Serves as a preparatory guide for today's practicing engineers

  13. Thermal reactor safety

    International Nuclear Information System (INIS)

    1980-06-01

    Information is presented concerning new trends in licensing; seismic considerations and system structural behavior; TMI-2 risk assessment and thermal hydraulics; statistical assessment of potential accidents and verification of computational methods; issues with respect to improved safety; human factors in nuclear power plant operation; diagnostics and activities in support of recovery; LOCA transient analysis; unresolved safety issues and other safety considerations; and fission product transport

  14. Thermal reactor safety

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    Information is presented concerning new trends in licensing; seismic considerations and system structural behavior; TMI-2 risk assessment and thermal hydraulics; statistical assessment of potential accidents and verification of computational methods; issues with respect to improved safety; human factors in nuclear power plant operation; diagnostics and activities in support of recovery; LOCA transient analysis; unresolved safety issues and other safety considerations; and fission product transport.

  15. Hydrogen Technologies Safety Guide

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Burgess, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Buttner, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-01-01

    The purpose of this guide is to provide basic background information on hydrogen technologies. It is intended to provide project developers, code officials, and other interested parties the background information to be able to put hydrogen safety in context. For example, code officials reviewing permit applications for hydrogen projects will get an understanding of the industrial history of hydrogen, basic safety concerns, and safety requirements.

  16. Radiation safety audit

    International Nuclear Information System (INIS)

    Kadadunna, K.P.I.K.; Mod Ali, Noriah

    2008-01-01

    Audit has been seen as one of the effective methods to ensure harmonization in radiation protection. A radiation safety audit is a formal safety performance examination of existing or future work activities by an independent team. Regular audit will assist the management in its mission to maintain the facilities environment that is inherently safe for its employees. The audits review the adequacy of facilities for the type of use, training, and competency of workers, supervision by authorized users, availability of survey instruments, security of radioactive materials, minimization of personnel exposure to radiation, safety equipment, and the required record keeping. All approved areas of use are included in these periodic audits. Any deficiency found in the audit shall be corrected as soon as possible after they are reported. Radiation safety audit is a proactive approach to improve radiation safety practices and identify and prevent any potential radiation accident. It is an excellent tool to identify potential problem to radiation users and to assure that safety measures to eliminate or reduce the problems are fully considered. Radiation safety audit will help to develop safety culture of the facility. It is intended to be the cornerstone of a safety program designed to aid the facility, staff and management in maintaining a safe environment in which activities are carried out. The initiative of this work is to evaluate the need of having a proper audit as one of the mechanism to manage the safety using ionizing radiation. This study is focused on the need of having a proper radiation safety audit to identify deviations and deficiencies of radiation protection programmes. It will be based on studies conducted on several institutes/radiation facilities in Malaysia in 2006. Steps will then be formulated towards strengthening radiation safety through proper audit. This will result in a better working situation and confidence in the radiation protection community

  17. Human factors in safety assessment. Safety culture assessment

    International Nuclear Information System (INIS)

    Zhang Li; Deng Zhiliang; Wang Yiqun; Huang Weigang

    1996-01-01

    This paper analyses the present conditions and problems in enterprises safety assessment, and introduces the characteristics and effects of safety culture. The authors think that safety culture must be used as a 'soul' to form the pattern of modern safety management. Furthermore, they propose that the human safety and synthetic safety management assessment in a system should be changed into safety culture assessment. Finally, the assessment indicators are discussed

  18. Equipment line-up developed for structuring programmed digital systems important to safety

    International Nuclear Information System (INIS)

    Remus, L.; Colling, J.M.; Buisson, J.

    1986-01-01

    The use of the programmed digital techniques in systems important to safety led to developing equipment line-ups which allow to procedure, through using a restricted number of sub-assemblies, a variety of facilities capable of performing diversified functions. Upon remembering the requirements that such equipment are required to meet (quality assurance both at the design and production stages, qualification, testing opportunities, etc.) the equipments produced by MERLIN GERIN are described in this paper. Such equipments include a whole set of printed circuit boards, plug-in units with self-engaging connectors and the related cabinets to accomodate them. The following systems are made up of such equipments: Digital integrated protection system; Rod control and monitoring system; Reactor power distribution monitoring equipment. This equipment line-up has been gradually complemented and is still further expanding both as a result of the component further development or for the purpose of meeting new requirements or applications (new digital neutron instrumentation, local area networks). Experience gained thus far provides us with the capability of working out in a short time programmed systems for further applications in the nuclear power field

  19. From cell biology to biotechnology in space.

    Science.gov (United States)

    Cogoli, A

    2000-09-01

    In this article I discuss the main results of our research in space biology from the simple early investigations with human lymphocytes in the early eighties until the projects in tissue engineering of the next decade on the international space station ISS. The discovery that T lymphocyte activation is nearly totally depressed in vitro in 0 g conditions showed that mammalian single cells are sensitive to the gravitational environment. Such finding had important implications in basic research, medicine and biotechnology. Low gravity can be used as a tool to investigate complicated and still obscure biological process from a new perspective not available to earth-bound laboratories. Low gravity may also favor certain bioprocesses involving the growth of tissues and thus lead to commercial and medical applications. However, shortage of crew time and of other resources, lack of sophisticated instrumentation, safety constraints pose serious limits to biological endeavors in space laboratories.

  20. Relationship of safety culture and process safety

    International Nuclear Information System (INIS)

    Olive, Claire; O'Connor, T. Michael; Mannan, M. Sam

    2006-01-01

    Throughout history, humans have gathered in groups for social, religious, and industrial purposes. As the conglomeration of people interact, a set of underlying values, beliefs, and principles begins to develop that serve to guide behavior within the group. These 'guidelines' are commonly referred to as the group culture. Modern-day organizations, including corporations, have developed their own unique cultures derived from the diversity of the organizational interests and the background of the employees. Safety culture, a sub-set of organizational culture, has been a major focus in recent years. This is especially true in the chemical industry due to the series of preventable, safety-related disasters that occurred in the late seventies and eighties. Some of the most notable disasters, during this time period, occurred at Bhopal, Flixborough, and Seveso. However, current events, like the September 11th terrorist attacks and the disintegration of the Columbia shuttle, have caused an assessment of safety culture in a variety of other organizations

  1. Governors Highway Safety Association

    Science.gov (United States)

    ... 2016, GHSA announced a partnership with the National Road Safety Foundation, Inc. See All Partner Initiatives ... Drivers Motorcyclists Seat Belts Speed and Red Light Cameras Speeding and Aggressive ...

  2. Safety performance indicators program

    International Nuclear Information System (INIS)

    Vidal, Patricia G.

    2004-01-01

    In 1997 the Nuclear Regulatory Authority (ARN) initiated a program to define and implement a Safety Performance Indicators System for the two operating nuclear power plants, Atucha I and Embalse. The objective of the program was to incorporate a set of safety performance indicators to be used as a new regulatory tool providing an additional view of the operational performance of the nuclear power plants, improving the ability to detect degradation on safety related areas. A set of twenty-four safety performance indicators was developed and improved throughout pilot implementation initiated in July 1998. This paper summarises the program development, the main criteria applied in each stage and the results obtained. (author)

  3. Lift truck safety review

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, L.C.

    1997-03-01

    This report presents safety information about powered industrial trucks. The basic lift truck, the counterbalanced sit down rider truck, is the primary focus of the report. Lift truck engineering is briefly described, then a hazard analysis is performed on the lift truck. Case histories and accident statistics are also given. Rules and regulations about lift trucks, such as the US Occupational Safety an Health Administration laws and the Underwriter`s Laboratories standards, are discussed. Safety issues with lift trucks are reviewed, and lift truck safety and reliability are discussed. Some quantitative reliability values are given.

  4. Lift truck safety review

    International Nuclear Information System (INIS)

    Cadwallader, L.C.

    1997-03-01

    This report presents safety information about powered industrial trucks. The basic lift truck, the counterbalanced sit down rider truck, is the primary focus of the report. Lift truck engineering is briefly described, then a hazard analysis is performed on the lift truck. Case histories and accident statistics are also given. Rules and regulations about lift trucks, such as the US Occupational Safety an Health Administration laws and the Underwriter's Laboratories standards, are discussed. Safety issues with lift trucks are reviewed, and lift truck safety and reliability are discussed. Some quantitative reliability values are given

  5. Light water reactor safety

    CERN Document Server

    Pershagen, B

    2013-01-01

    This book describes the principles and practices of reactor safety as applied to the design, regulation and operation of light water reactors, combining a historical approach with an up-to-date account of the safety, technology and operating experience of both pressurized water reactors and boiling water reactors. The introductory chapters set out the basic facts upon which the safety of light water reactors depend. The central section is devoted to the methods and results of safety analysis. The accidents at Three Mile Island and Chernobyl are reviewed and their implications for light wate

  6. Improved safety at CERN

    CERN Multimedia

    2006-01-01

    As announced in Weekly Bulletin No. 43/2006, a new approach to the implementation of Safety at CERN has been decided, which required taking some managerial decisions. The guidelines of the new approach are described in the document 'New approach to Safety implementation at CERN', which also summarizes the main managerial decisions I have taken to strengthen compliance with the CERN Safety policy and Rules. To this end I have also reviewed the mandates of the Safety Commission and the Safety Policy Committee (SAPOCO). Some details of the document 'Safety Policy at CERN' (also known as SAPOCO42) have been modified accordingly; its essential principles, unchanged, remain the basis for the safety policy of the Organisation. I would also like to inform you that I have appointed Dr M. Bona as the new Head of the Safety Commission until 31.12.2008, and that I will proceed soon to the appointment of the members of the new Safety Policy Committee. All members of the personnel are deemed to have taken note of the d...

  7. FOOD SAFETY TESTING LABORATORY

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory develops screening assays, tests and modifies biosensor equipment, and optimizes food safety testing protocols for the military and civilian sector...

  8. La designación de gabinetes en Uruguay: estrategia legislativa, jerarquía de los ministerios y afiliación partidaria de los ministros Cabinet Appointment in Uruguay: Legislative Strategy, hierarchy of portfolio and party affiliation of ministers

    Directory of Open Access Journals (Sweden)

    Daniel CHASQUETTI

    2013-07-01

    Full Text Available El artículo analiza la formación y cambio de gabinetes presidenciales en Uruguay durante el período 1985-2010. La primera sección presenta los rasgos institucionales y políticos del proceso de designación y renuncia de los ministros. La segunda describe los gabinetes formados en el período, mostrando que en general los presidentes ceden carteras a cambio de apoyo legislativo. La tercera sección analiza los atributos políticos de los ministros designados (filiación partidaria, experiencia previa y el tipo de vínculo que desarrollan con el presidente. La cuarta analiza la relación entre la supervivencia de los ministros en su cargo, la responsabilidad política ante el Congreso y la existencia de mayorías legislativas favorables al gobierno. En la última sección se describe la existencia en Uruguay de un patrón de designación del gabinete cuyos atributos principales serían (i el establecimiento de un orden jerárquico de las carteras, (ii la nominación de individuos con filiación partidaria (ya sean políticos insiders o adherentes y (iii la influencia de los apoyos legislativos en la definición del elenco ministerial.The article analyzes the formation and change of presidential cabinets in Uruguay during the period 1985-2010. In the first section we present the institutional and political features of the process of appointment and resignation of the ministers. The second section describes the cabinets formed in this period and shows that presidents have exchanged seats in cabinet by legislative support. The third section analyzes the political attributes of the ministers appointed (party affiliation, previous experience and the type of linkage that they keep with the president. The fourth analyze the relationship between the time survival of the individuals in office, the political responsibility in front of congress and the existence of a legislative majority that support the president. The last section describes the

  9. Standard biological parts knowledgebase.

    Science.gov (United States)

    Galdzicki, Michal; Rodriguez, Cesar; Chandran, Deepak; Sauro, Herbert M; Gennari, John H

    2011-02-24

    We have created the Knowledgebase of Standard Biological Parts (SBPkb) as a publically accessible Semantic Web resource for synthetic biology (sbolstandard.org). The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts (partsregistry.org). SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL), a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  10. Biologic fatigue in psoriasis.

    Science.gov (United States)

    Levin, Ethan C; Gupta, Rishu; Brown, Gabrielle; Malakouti, Mona; Koo, John

    2014-02-01

    Over the past 15 years, biologic medications have greatly advanced psoriasis therapy. However, these medications may lose their efficacy after long-term use, a concept known as biologic fatigue. We sought to review the available data on biologic fatigue in psoriasis and identify strategies to help clinicians optimally manage patients on biologic medications in order to minimize biologic fatigue. We reviewed phase III clinical trials for the biologic medications used to treat psoriasis and performed a PubMed search for the literature that assessed the loss of response to biologic therapy. In phase III clinical trials of biologic therapies for the treatment of psoriasis, 20-32% of patients lost their PASI-75 response during 0.8-3.9 years of follow-up. A study using infliximab reported the highest percentage of patients who lost their response (32%) over the shortest time-period (0.8 years). Although not consistently reported across all studies, the presence of antidrug antibodies was associated with the loss of response to treatment with infliximab and adalimumab. Biologic fatigue may be most frequent in those patients using infliximab. Further studies are needed to identify risk factors associated with biologic fatigue and to develop meaningful antidrug antibody assays.

  11. Standard biological parts knowledgebase.

    Directory of Open Access Journals (Sweden)

    Michal Galdzicki

    2011-02-01

    Full Text Available We have created the Knowledgebase of Standard Biological Parts (SBPkb as a publically accessible Semantic Web resource for synthetic biology (sbolstandard.org. The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts (partsregistry.org. SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL, a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  12. Investigative safety science as a competitive advantage for Pharma.

    Science.gov (United States)

    Moggs, Jonathan; Moulin, Pierre; Pognan, Francois; Brees, Dominique; Leonard, Michele; Busch, Steve; Cordier, Andre; Heard, David J; Kammüller, Michael; Merz, Michael; Bouchard, Page; Chibout, Salah-Dine

    2012-09-01

    Following a US National Academy of Sciences report in 2007 entitled "Toxicity Testing of the 21st Century: a Vision and a Strategy," significant advances within translational drug safety sciences promise to revolutionize drug discovery and development. The purpose of this review is to outline why investigative safety science is a competitive advantage for the pharmaceutical industry. The article discusses the essential goals for modern investigative toxicologists including: cross-species target biology; molecular pathways of toxicity; and development of predictive tools, models and biomarkers that allow discovery researchers and clinicians to anticipate safety problems and plan ways to address them, earlier than ever before. Furthermore, the article emphasizes the importance of investigating unanticipated clinical safety signals through a combination of mechanistic preclinical studies and/or molecular characterization of clinical samples from affected organs. The traditional boundaries between pharma industry teams focusing on safety/efficacy and preclinical/clinical development are rapidly disappearing in favor of translational safety science-centric organizations with a vision of bringing more effective medicines forward safely and quickly. Comparative biology and mechanistic toxicology approaches facilitate: i) identifying translational safety biomarkers; ii) identifying new drug targets/indications; and iii) mitigating off-target toxicities. These value-adding safety science contributions will change traditional toxicologists from side-effect identifiers to drug development enablers.

  13. Pharmacovigilance of Biologics in a Multisource Environment.

    Science.gov (United States)

    Sagi, Sreedhar; Cohen, Hillel P; Woollett, Gillian R

    2017-12-01

    It is important that systems are in place to ensure that appropriate and comprehensive records are kept for use of all medications. It is fundamental to an effective pharmacovigilance system that patient medical records contain sufficient information to identify which medication has been prescribed, when it was administered, and at what dose. The availability of biologics from multiple sponsors has raised questions by some health care providers about the ability of current pharmacovigilance systems to trace specific biologics. In this article, periodic safety update reports were used to assess current postapproval safety monitoring for 3 biosimilars (epoetin alfa, somatropin, and filgrastim) that collectively represented nearly 350 million patient days of treatment worldwide. The reference products have each been marketed for over 10 years, forming a strong baseline of postmarketing safety data against which the safety of biosimilars can be compared. Published data from Denmark were also reviewed as additional evidence of how current pharmacovigilance systems are able to attribute adverse events to particular medicines. Collectively, the data show that spontaneous adverse drug reactions are reported by brand name in the majority of cases and are attributable to a specific medicine. Also discussed are the informational elements critical to monitoring biologics, or indeed any medicine, to ensure the availability of complete information so medicines that a patient has received can be quickly identified should a safety event occur. We support the addition of a single data element, the batch/lot number, to enhance the value of current pharmacovigilance systems. Adoption of 2-D barcodes in the European Union (EU) and standardized numerical identifiers in the United States addresses this need, since they include batch/lot numbers. These identifiers are already being implemented in the United States and the EU to improve patient safety, reduce medication errors, facilitate

  14. Safety case plan 2008

    International Nuclear Information System (INIS)

    2008-07-01

    Following the guidelines set forth by the Ministry of Trade and Industry (now Ministry of Employment and Economy) Posiva is preparing to submit the construction license application for a spent fuel repository by the end of the year 2012. The long-term safety section supporting the license application is based on a safety case, which, according to the internationally adopted definition, is a compilation of the evidence, analyses and arguments that quantify and substantiate the safety and the level of expert confidence in the safety of the planned repository. In 2005, Posiva presented a plan to prepare such a safety case. The present report provides a revised plan of the safety case contents mentioned above. The update of the safety case plan takes into account the recommendations made by the Radiation and Nuclear Safety Authority (STUK) about improving the focus and further developing the plan. Accordingly, particular attention is given to the quality management of the safety case work, the management of uncertainties and the scenario methodology. The quality management is based on the ISO 9001:2000 standard process thinking enhanced with special features arising from STUK's YVL Guides. The safety case production process is divided into four main sub-processes. The conceptualisation and methodology sub-process defines the framework for the assessment. The critical data handling and modelling sub-process links Posiva's main technical and scientific activities to the production of the safety case. The assessment sub-process analyses the consequences of the evolution of the disposal system in various scenarios, classified either as part of the expected evolution or as disruptive scenarios. The compliance and confidence sub-process is responsible for final evaluation of compliance of the assessment results with the regulatory criteria and the overall confidence in the safety case. As in the previous safety case plan, the safety case will be based on several reports, but

  15. Branching processes in biology

    CERN Document Server

    Kimmel, Marek

    2015-01-01

    This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second ex...

  16. Biological tracer method

    Science.gov (United States)

    Strong-Gunderson, Janet M.; Palumbo, Anthony V.

    1998-01-01

    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer.

  17. Plant synthetic biology.

    Science.gov (United States)

    Liu, Wusheng; Stewart, C Neal

    2015-05-01

    Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate.

  19. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate

  20. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January - December 1996

    International Nuclear Information System (INIS)

    Kszos, L.A.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate

  1. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate.

  2. Public attitudes toward legally coerced biological treatments of criminals.

    Science.gov (United States)

    Berryessa, Colleen M; Chandler, Jennifer A; Reiner, Peter

    2016-12-01

    How does the public view the offer of a biological treatment in lieu of prison for criminal offenders? Using the contrastive vignette technique, we explored this issue, using mixed-methods analysis to measure concerns regarding changing the criminal's personality, the coercive nature of the offer, and the safety of the proposed treatment. Overall, we found that of the three variables, the safety of the pill had the strongest effect on public acceptance of a biological intervention. Indeed, it was notable that the public was relatively sanguine about coercive offers of biological agents, as well as changing the personality of criminals. While respondents did not fully endorse such coercive offers, neither were they outraged by the use of biological treatments of criminals in lieu of incarceration. These results are discussed in the context of the retributive and rehabilitative sentiments of the public, and legal jurisprudence in the arena of human rights law.

  3. Biological detector and method

    Science.gov (United States)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2013-02-26

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  4. Future biologic therapies in asthma.

    Science.gov (United States)

    Quirce, Santiago; Bobolea, Irina; Domínguez-Ortega, Javier; Barranco, Pilar

    2014-08-01

    Despite the administration of appropriate treatment, a high number of patients with asthma remain uncontrolled. This suggests the need for alternative treatments that are effective, safe and selective for the established asthma phenotypes, especially in patients with uncontrolled severe asthma. The most promising options among the new asthma treatments in development are biological therapies, particularly those monoclonal antibodies directed at selective targets. It should be noted that the different drugs, and especially the new biologics, act on very specific pathogenic pathways. Therefore, determination of the individual profile of predominant pathophysiological alterations of each patient will be increasingly important for prescribing the most appropriate treatment in each case. The treatment of severe allergic asthma with anti-IgE monoclonal antibody (omalizumab) has been shown to be effective in a large number of patients, and new anti-IgE antibodies with improved pharmacodynamic properties are being investigated. Among developing therapies, biologics designed to block certain pro-inflammatory cytokines, such as IL-5 (mepolizumab) and IL-13 (lebrikizumab), have a greater chance of being used in the clinic. Perhaps blocking more than one cytokine pathway (such as IL-4 and IL-13 with dulipumab) might confer increased efficacy of treatment, along with acceptable safety. Stratification of asthma based on the predominant pathogenic mechanisms of each patient (phenoendotypes) is slowly, but probably irreversibly, emerging as a tailored medical approach to asthma, and is becoming a key factor in the development of drugs for this complex respiratory syndrome. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  5. Highway Safety Program Manual: Volume 3: Motorcycle Safety.

    Science.gov (United States)

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Volume 3 of the 19-volume Highway Safety Program Manual (which provides guidance to State and local governments on preferred highway safety practices) concentrates on aspects of motorcycle safety. The purpose and specific objectives of a State motorcycle safety program are outlined. Federal authority in the highway safety area and general policies…

  6. Biological Water Quality Criteria

    Science.gov (United States)

    Page contains links to Technical Documents pertaining to Biological Water Quality Criteria, including, technical assistance documents for states, tribes and territories, program overviews, and case studies.

  7. Space Synthetic Biology (SSB)

    Data.gov (United States)

    National Aeronautics and Space Administration — This project focused on employing advanced biological engineering and bioelectrochemical reactor systems to increase life support loop closure and in situ resource...

  8. Systems Biology of Metabolism.

    Science.gov (United States)

    Nielsen, Jens

    2017-06-20

    Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.

  9. Safety Training: basic safety and access courses

    CERN Multimedia

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various hazards existing on site, and how to recognise and avoid them. Safety course changes The current organisation of basic safety courses is changing. There will be two main modifications: the organisation of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organisational changes This concerns the existing basic safety training, currently called level 1, level 2 and level 3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, participants will systematically follow...

  10. Safety Training: Basic Safety and Access Courses

    CERN Multimedia

    Antonella Vignes

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various existing on-site hazards, and how to recognize and avoid them. Safety course changes The current organization for basic safety courses is changing. There will be two main modifications: the organization of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organizational changes This concerns the existing basic safety training, currently called level1, level2 and level3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, attendees will systematically follow the...

  11. Nuclear safety in perspective

    International Nuclear Information System (INIS)

    Andersson, K.; Sjoeberg, B.M.D.; Lauridsen, K.; Wahlstroem, B.

    2002-06-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicating on the subject in society. The project, which has been built around a number of seminars, was supported by limited research in three sub-projects: 1) Risk assessment, 2) Safety analysis, and 3) Strategies for safety management. The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems for regulatory oversight are described in the nuclear area and also, to widen the perspective, for other industrial areas. Transparency and public participation are described as key elements in good risk communication, and case studies are given. Environmental Impact Assessment and Strategic Environmental Assessment are described as important overall processes within which risk communication can take place. Safety culture, safety indicators and quality systems are important concepts in the nuclear safety area are very useful, but also offer important challenges for the future. They have been subject to special attention in the project. (au)

  12. Aviation safety and ICAO

    NARCIS (Netherlands)

    Huang, Jiefang

    2009-01-01

    The thesis addresses the issue of aviation safety under the rule of law. Aviation safety is a global concern. While air transport is considered a safe mode of travel, it is susceptible to inherent risks of flight, the use of force, and terrorist acts. Consequently, within the framework of the

  13. Modelling blood safety

    NARCIS (Netherlands)

    Janssen, M.P.

    2010-01-01

    This thesis describes the development and application of methods and models to support decision making on safety measures aimed at preventing the transmission of infections by blood donors. Safety measures refer to screening tests for blood donors, quarantine periods for blood plasma, or methods for

  14. Idaho Safety Manual.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This manual is intended to help teachers, administrators, and local school boards develop and institute effective safety education as a part of all vocational instruction in the public schools of Idaho. This guide is organized in 13 sections that cover the following topics: introduction to safety education, legislation, levels of responsibility,…

  15. Safety in Aquaculture

    Science.gov (United States)

    Durborow, Robert M.; Myers, Melvin L.

    2016-01-01

    In this article, occupational safety interventions for agriculture-related jobs, specifically in aquaculture, are reviewed. Maintaining quality of life and avoiding economic loss are two areas in which aquaculturists can benefit by incorporating safety protocols and interventions on their farms. The information in this article is based on farm…

  16. Safety Behaviors and Stuttering

    Science.gov (United States)

    Lowe, Robyn; Helgadottir, Fjola; Menzies, Ross; Heard, Rob; O'Brian, Sue; Packman, Ann; Onslow, Mark

    2017-01-01

    Purpose: Those who are socially anxious may use safety behaviors during feared social interactions to prevent negative outcomes. Safety behaviors are associated with anxiety maintenance and poorer treatment outcomes because they prevent fear extinction. Social anxiety disorder is often comorbid with stuttering. Speech pathologists reported in a…

  17. Safety in cardiac surgery

    NARCIS (Netherlands)

    Siregar, S.

    2013-01-01

    The monitoring of safety in cardiac surgery is a complex process, which involves many clinical, practical, methodological and statistical issues. The objective of this thesis was to measure and to compare safety in cardiac surgery in The Netherlands using the Netherlands Association for

  18. Probabilistic safety analyses (PSA)

    International Nuclear Information System (INIS)

    1997-01-01

    The guide shows how the probabilistic safety analyses (PSA) are used in the design, construction and operation of light water reactor plants in order for their part to ensure that the safety of the plant is good enough in all plant operational states

  19. Bicycle Safety in Action.

    Science.gov (United States)

    National Commission on Safety Education, Washington, DC.

    This material was designed to assist schools in teaching bicycle safety. As the population grows and competition for road space increases, it is more imperative than ever that we concentrate attention on the need for caution among pupil cyclists. The pamphlet: (1) discusses the role of bicycle safety in classroom instruction and in student…

  20. Seeking a safety culture

    International Nuclear Information System (INIS)

    Lee, T.

    1993-01-01

    Human organisational failure has been shown to play a significant role in major accidents world-wide in both the nuclear and non-nuclear industries. A recent report called Organising for Safety, published by The Health and Safety Commission, suggests that the nuclear industry should give organisational factors the same emphasis as it does the reduction of equipment failures and individual error. (Author)