WorldWideScience

Sample records for biological characteristics return

  1. [Cycloferon biological activity characteristics].

    Science.gov (United States)

    Utkina, T M; Potekhina, L P; Kartashova, O L; Vasilchenko, A S

    2014-01-01

    Study the effect of cycloferon in experimental and clinical conditions on persistence properties of aurococci as well as features of their morpho-functional reaction by atomic force microscopy. The study was carried out in 12 Staphylococcus aureus clones isolated from mucous membrane of nose anterior part of a resident carrier. The effect of cycloferon in vivo was evaluated in 26 resident staphylococci carriers under the control of anti-carnosine activity of staphylococci. Anti-carnosine activity was determined by O.V. Bukharin et al. (1999), biofilm formation -by G.A. O'Toole et al. (2000). Staphylococci treated with cycloferon were studied by atomic force microscopy in contact mode using scanning probe SMM-2000 microscope. The decrease of persistence properties of staphylococci under the effect of cycloferon in vitro and in vivo may be examined as one of the mechanisms of biological activity of the preparation. A significant increase of S. aureus surface roughness and changes in their morphology under the effect of cycloferon allow stating the disorder of barrier functions in the aurococci cell wall. The data obtained expand the understanding of cycloferon biological activity mechanisms.

  2. Biological couplings: Classification and characteristic rules

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The phenomena that biological functions originate from biological coupling are the important biological foundation of multiple bionics and the significant discoveries in the bionic fields. In this paper, the basic concepts related to biological coupling are introduced from the bionic viewpoint. Constitution, classification and characteristic rules of biological coupling are illuminated, the general modes of biological coupling studies are analyzed, and the prospects of multi-coupling bionics are predicted.

  3. Characteristics of donors who do or do not return to give blood and barriers to their return

    Science.gov (United States)

    Wevers, Anne; Wigboldus, Daniël H.J.; de Kort, Wim L.A.M.; van Baaren, Rick; Veldhuizen, Ingrid J.T.

    2014-01-01

    Background In the Netherlands about 50% of whole blood donors return to give blood after an invitation to donate. This study aimed to investigate the characteristics of donor return behaviour and to gain insight into the barriers to blood donation reported by the donors themselves. Materials and methods A total of 4,901 whole blood donors were invited to donate in week 39 of 2009. Barriers mentioned by donors who informed the blood bank for not donating were registered for 1 month. Logistic regression analyses assessed relevant characteristics of return behaviour, such as age and blood type, in men and women separately. Results Of the invited donors, 55% returned to give a donation, whereas 45% did not return. Male donors were more likely to return when they were older, had a higher previous return rate and had no past deferrals. The same pattern was found among women, but was less strong. The main barriers were: time constraints (35%), preference to postpone donation due to general physical problems although being eligible to donate (29%), and being ineligible to donate due to medical deferral criteria (9%). Discussion Specific donor characteristics are associated with return behaviour. Not donating due to time constraints could mean that donors do not feel the urgency of donating blood. Interventions targeted to increase commitment among specific donor groups should be tested further. PMID:23522891

  4. A critical evaluation of risk-return characteristics of environmentally focused stock’s companies

    Directory of Open Access Journals (Sweden)

    Stanislav Škapa

    2013-01-01

    Full Text Available The objective of the paper is to critically evaluate and determine risk-return profile environmentally focused stock’s companies which are covered by STOXX Global ESG Environmental Leaders Index and whether this index should be taken in as an independent asset class of investments portfolio for its risk-return improvement. This paper gives an empirical view on the ex-post asset classes characteristics focused mainly on risk side of investment.

  5. Prediction of Some Biological Film Characteristic

    International Nuclear Information System (INIS)

    Ibrahim, G.; Khalaf, K.

    2004-01-01

    A multi components biofilm model has been developed and discussed which accounts for all well established biological processes with biofilm(s): s ubstrate utilization [aerobically, axenically and anaerobically]. D enitrification process. n itrification process. t he effect of diffusion and mass transfer limitations. The model has predicted some important characteristics of bio films such as:- s pace distribution of substrate(s) within bio films. W eight or thickness of biofilm layer (aerobic layer, anoxic layer and anaerobic layer). The results indicates that the relative thickness of biofilm layers (aerobically, anoxically and anaerobic) is highly affected by the availability of the main electron acceptor (O 2 and NO 3 and the organic load)

  6. Biological and technological characteristics of Georgian wine and table grapes

    Directory of Open Access Journals (Sweden)

    Ujmajuridze Levan

    2015-01-01

    Description of grapevine varieties implemented through the descriptors for grapevine (IPGRI OIV. Botanical, biological-technological, qualitative and quantitative marks are characterized and evaluated. Investigation conducted during the biologic development phases were studied for chemical and eno-carpological characteristics.

  7. Reproductive biology characteristic of Jatropha curcas (Euphorbiaceae).

    Science.gov (United States)

    Wang, Xiu-Rong; Ding, Gui-Jie

    2012-12-01

    Jatropha curcas belongs to family of Euphorbiaceae, and is an important biological tree species for diesel production. The current descriptions of the phenotypic traits for male and female flowers are not comprehensive and there have been no reports about the process of J. curcas from pollen germination on stigma to pollen tubes conducting fertilization after entering the ovary and ovule. To assess this, experiments were undertaken to study the reproductive biology characteristic of J. curcas in Guiyang Guizhou Province, China. Floral structure and pollen germination process were described in detail and the breeding system was determined. The results showed that flower of J. curcas was both unisexual and monoecious, with a flowering phase between April-November. Both female and male flowers have five petals in contorted arrangement and five calyxes in imbricated arrangement. Female flower originated from bisexual flower finally formed unisexual flowers as the stamen ceased growth in different period. The pistil had 3-5 styles, connected at base and separated into 3-5 stigmas on the top. Each stigma had 2-4 lobes. The styles were hollow. The pollen germinated on the surface of the stigma, is then transported via the vascular tissues, which was arranged in bundles, and finally channeled through the micropyle to enter the blastula. The pollen tube was shaped in a long uneven cylinder. The top end of it became swollen and formed a small round hole for the purpose of releasing sperm nuclei while the pollen tube itself was growing and extending. Estimation of out-crossing index and artificial pollination experiments indicated that J. curcas was capable of both self-pollination and cross-pollination. The germination speed of the pollen on the stigma did not differ so much between the one by self-pollination and the one by cross-pollination, and the pollen from the two different sources could both reach the ovary within one day. Both artificial pollination test and out

  8. Reproductive biology characteristic of Jatropha curcas (Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    Xiu-Rong Wang

    2012-12-01

    Full Text Available Jatropha curcas belongs to family of Euphorbiaceae, and is an important biological tree species for diesel production. The current descriptions of the phenotypic traits for male and female flowers are not comprehensive and there have been no reports about the process of J. curcas from pollen germination on stigma to pollen tubes conducting fertilization after entering the ovary and ovule. To assess this, experiments were undertaken to study the reproductive biology characteristic of J. curcas in Guiyang Guizhou Province, China. Floral structure and pollen germination process were described in detail and the breeding system was determined. The results showed that flower of J. curcas was both unisexual and monoecious, with a flowering phase between April-November. Both female and male flowers have five petals in contorted arrangement and five calyxes in imbricated arrangement. Female flower originated from bisexual flower finally formed unisexual flowers as the stamen ceased growth in different period. The pistil had 3-5 styles, connected at base and separated into 3-5 stigmas on the top. Each stigma had 2-4 lobes. The styles were hollow. The pollen germinated on the surface of the stigma, is then transported via the vascular tissues, which was arranged in bundles, and finally channeled through the micropyle to enter the blastula. The pollen tube was shaped in a long uneven cylinder. The top end of it became swollen and formed a small round hole for the purpose of releasing sperm nuclei while the pollen tube itself was growing and extending. Estimation of out-crossing index and artificial pollination experiments indicated that J. curcas was capable of both self-pollination and cross-pollination. The germination speed of the pollen on the stigma did not differ so much between the one by self-pollination and the one by cross-pollination, and the pollen from the two different sources could both reach the ovary within one day. Both artificial

  9. Reproductive biology characteristic of Jatropha curcas (Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    Xiu-Rong Wang

    2012-12-01

    Full Text Available Jatropha curcas belongs to family of Euphorbiaceae, and is an important biological tree species for diesel production. The current descriptions of the phenotypic traits for male and female flowers are not comprehensive and there have been no reports about the process of J. curcas from pollen germination on stigma to pollen tubes conducting fertilization after entering the ovary and ovule. To assess this, experiments were undertaken to study the reproductive biology characteristic of J. curcas in Guiyang Guizhou Province, China. Floral structure and pollen germination process were described in detail and the breeding system was determined. The results showed that flower of J. curcas was both unisexual and monoecious, with a flowering phase between April-November. Both female and male flowers have five petals in contorted arrangement and five calyxes in imbricated arrangement. Female flower originated from bisexual flower finally formed unisexual flowers as the stamen ceased growth in different period. The pistil had 3-5 styles, connected at base and separated into 3-5 stigmas on the top. Each stigma had 2-4 lobes. The styles were hollow. The pollen germinated on the surface of the stigma, is then transported via the vascular tissues, which was arranged in bundles, and finally channeled through the micropyle to enter the blastula. The pollen tube was shaped in a long uneven cylinder. The top end of it became swollen and formed a small round hole for the purpose of releasing sperm nuclei while the pollen tube itself was growing and extending. Estimation of out-crossing index and artificial pollination experiments indicated that J. curcas was capable of both self-pollination and cross-pollination. The germination speed of the pollen on the stigma did not differ so much between the one by self-pollination and the one by cross-pollination, and the pollen from the two different sources could both reach the ovary within one day. Both artificial

  10. Exiting the Emergency Medical Services Profession and Characteristics Associated with Intent to Return to Practice.

    Science.gov (United States)

    Cash, Rebecca E; Crowe, Remle P; Agarwal, Riddhima; Rodriguez, Severo A; Panchal, Ashish R

    2018-01-01

    Inadequate staffing of agencies, increasing attrition rates, and frequent turnover of personnel make employee retention an ongoing concern for Emergency Medical Services (EMS). Faced with increasing demand for EMS, understanding the causes underlying turnover is critical. The objectives of this study were to describe the proportion of individuals that left EMS, likelihood of returning to the profession, and key factors contributing to the decision to leave EMS. This was a cross-sectional study of nationally-certified EMS professionals who left EMS. Respondents to a census survey who reported not practicing EMS were directed to a subsection of items regarding their choice to leave EMS. Demographic and employment characteristics, likelihood of returning to EMS, and factors influencing the decision to leave EMS were assessed. Descriptive and comparative statistics (Chi-square and nonparametric test of trend [p-trend]) and univariable odds ratios were calculated. The overall response rate for the full survey was 10% (n = 32,114). A total of 1247 (4%) respondents reported leaving the profession and completed the exit survey. The majority (72%) reported that they will likely return to EMS. A stepwise decrease in the reported likelihood of returning was seen with increasing years of EMS experience (e.g., 2 or less years of experience: 83%; 16 or more years: 52%; p-trend benefits (65%), decision to pursue further education (60%), dissatisfaction with organization's management (54.7%), and desire for career change (54.1%). This cross-sectional study found an attrition rate of approximately 4% among nationally certified EMS professionals; however, the majority reported that they intended to return to the EMS profession. Intention to return to EMS decreased as years of experience and months away from the profession increased. Important factors in the decision to leave EMS included a desire for better pay and benefits and the decision to pursue further education. Targeting the

  11. [Biological characteristics of calliphoridae and its application in forensic medicine].

    Science.gov (United States)

    Zhao, Boa; Wen, Charn; Qi, Li-Li; Wang, He; Wang, Ji

    2013-12-01

    Diptera Calliphoridae is the first major kind of flies that appears on the decomposed corpses. In forensic entomology, according to the living characteristics of Calliphoridae flies, we could accurately estimate postmortem interval (PMI) in a murder or unidentified case and could provide useful clues to solve the case. This paper introduces the characteristics of the biology and morphology of Diptera Calliphoridae, and reviews the combined application of forensic entomology, molecular biology, mathematical morphology and toxicology.

  12. Intervention characteristics that facilitate return to work after sickness absence: a systematic literature review.

    Science.gov (United States)

    Hoefsmit, Nicole; Houkes, Inge; Nijhuis, Frans J N

    2012-12-01

    In many Western countries, a vast amount of interventions exist that aim to facilitate return to work (RTW) after sickness absence. These interventions are usually focused on specific target populations such as employees with low back pain, stress-related complaints or adjustment disorders. The aim of the present study is to detect and identify characteristics of RTW interventions that generally facilitate return to work (i.e. in multiple target populations and across interventions). This type of knowledge is highly relevant to policy makers and health practitioners who want to deliver evidence based care that supports the employee's health and participation in labour. We performed a keyword search (systematic literature review) in seven databases (period: 1994-2010). In total, 23 articles were included and assessed for their methodological quality. The characteristics of the interventions were evaluated as well. Early interventions, initiated in the first 6 weeks of the RTW process were scarce. These were effective to support RTW though. Multidisciplinary interventions appeared effective to support RTW in multiple target groups (e.g. back pain and adjustment disorders). Time contingent interventions in which activities followed a pre-defined schedule were effective in all physical complaints studied in this review. Activating interventions such as gradual RTW were effective in physical complaints. They have not been studied for people with psychological complaints. Early- and multidisciplinary intervention and time-contingent-, activating interventions appear most effective to support RTW.

  13. Some physico-chemical and biological characteristics of soil and ...

    African Journals Online (AJOL)

    Environmental conditions that influence biocorrosion in the Niger Delta area of Nigeria are investigated experimentally by analysing the physico-chemical and biological characteristics of four (4) soil samples and water samples taken from ten (10) selected river bodies in the region. Measured properties of the water ...

  14. Work characteristics and return to work in long-term sick-listed employees with depressive symptoms.

    NARCIS (Netherlands)

    Huijs, J.J.J.M.; Koppes, L.L.J.; Taris, T.W.; Blonk, R.W.B.

    2017-01-01

    Purpose: The present study investigated the relations between work characteristics, depressive symptoms and duration until full return to work (RTW) among long-term sick-listed employees. This knowledge may add to the development of effective interventions and prevention, especially since work

  15. Work characteristics and return to work in long-term sick-listed employees with depressive symptoms

    NARCIS (Netherlands)

    Huijs, Jenny; Koppes, L.L.J.; Taris, A.W.; Blonk, R.W.B.

    2017-01-01

    Purpose The present study investigated the relations between work characteristics, depressive symptoms and duration until full return to work (RTW) among long-term sick-listed employees. This knowledge may add to the development of effective interventions and prevention, especially since work

  16. Work Characteristics and Return to Work in Long-Term Sick-Listed Employees with Depressive Symptoms

    NARCIS (Netherlands)

    Huijs, J.J.J.M.; Koppes, L.L.J.; Taris, T.W.; Blonk, R.WE.B.

    2017-01-01

    Purpose The present study investigated the relations between work characteristics, depressive symptoms and duration until full return to work (RTW) among long-term sick-listed employees. This knowledge may add to the development of effective interventions and prevention, especially since work

  17. Dosimetric characteristics of biological effect of sulfur-35

    International Nuclear Information System (INIS)

    Borisova, V.V.

    1990-01-01

    Experimental materials related to evaluation of dosimetric characteristics of sulfur-35 are presented. Hemogenic organs are subjected to greatest influence especially in the first hours after radionuclide entry into the organism. Comparison is made of absorbed doses in blood with observed blastomogen effect of hemogenic organs. It is noted, that quantitative evaluation of relative biological efficiency of low energy beta-emitters should be performed with account of dosimetric peculiarities of the nuclides mentioned above. 10 refs.; 3 tabs

  18. Genetic variability of muscle biological characteristics of young limousin bulls

    OpenAIRE

    Renand, Gilles; Jurie, Catherine; Robelin, Jacques; Picard, Brigitte; Geay, Y.; Menissier, Francois

    1995-01-01

    Genetic parameters of 4 muscle biological characteristics (protein to DNA ratio (Pro/DNA), lactate dehydrogenase (LDH) activity, isocitrate dehydrogenase (ICDH) activity and the proportion of type I myosin heavy chains (MHC I)), in the Semitendinosus and the Longissimus thoracis, were estimated simultaneously with average daily gain (ADG), 480-d final weight (FW), carcass lean and fat contents (CL% and CF% respectively) in a sample of young Limousin bulls tested in station. The data came f...

  19. Characteristics of Omega-Optimized Portfolios at Different Levels of Threshold Returns

    Directory of Open Access Journals (Sweden)

    Renaldas Vilkancas

    2014-12-01

    Full Text Available There is little literature considering effects that the loss-gain threshold used for dividing good and bad outcomes by all downside (upside risk measures has on portfolio optimization and performance. The purpose of this study is to assess the performance of portfolios optimized with respect to the Omega function developed by Keating and Shadwick at different levels of the threshold returns. The most common choices of the threshold values used in various Omega studies cover the risk-free rate and the average market return or simply a zero return, even though the inventors of this measure for risk warn that “using the values of the Omega function at particular points can be critically misleading” and that “only the entire Omega function contains information on distribution”. The obtained results demonstrate the importance of the selected values of the threshold return on portfolio performance – higher levels of the threshold lead to an increase in portfolio returns, albeit at the expense of a higher risk. In fact, within a certain threshold interval, Omega-optimized portfolios achieved the highest net return, compared with all other strategies for portfolio optimization using three different test datasets. However, beyond a certain limit, high threshold values will actually start hurting portfolio performance while meta-heuristic optimizers typically are able to produce a solution at any level of the threshold, and the obtained results would most likely be financially meaningless.

  20. The correlation between the imaging characteristics of hamstring injury and time required before returning to sports: a literature review.

    Science.gov (United States)

    Svensson, Kjell; Alricsson, Marie; Eckerman, Mattias; Magounakis, Theofilos; Werner, Suzanne

    2016-06-01

    Injuries to the hamstring muscles are common in athletes. Track and field, Australian football, American football and soccer are examples of sports where hamstring injuries are the most common. The purpose of this study was to investigate whether there is a correlation between a hamstring injury prognosis and its characteristics of imaging parameters. The literature search was performed in the databases PubMed and CINAHL, and eleven articles were included. Seven out of the 11 articles showed a correlation between the size of the hamstring injury and length of time required before returning to sports. Different authors have reported contrasting results about length of time required before returning to sports due to location of injury within specific muscle. Majority of the articles found hamstring strain correlated to an extended amount of time required before returning to sports.

  1. Biological characteristics of crucian by quantitative inspection method

    Science.gov (United States)

    Chu, Mengqi

    2015-04-01

    Biological characteristics of crucian by quantitative inspection method Through quantitative inspection method , the biological characteristics of crucian was preliminary researched. Crucian , Belongs to Cypriniformes, Cyprinidae, Carassius auratus, is a kind of main plant-eating omnivorous fish,like Gregarious, selection and ranking. Crucian are widely distributed, perennial water all over the country all have production. Determine the indicators of crucian in the experiment, to understand the growth, reproduction situation of crucian in this area . Using the measured data (such as the scale length ,scale size and wheel diameter and so on) and related functional to calculate growth of crucian in any one year.According to the egg shape, color, weight ,etc to determine its maturity, with the mean egg diameter per 20 eggs and the number of eggs per 0.5 grams, to calculate the relative and absolute fecundity of the fish .Measured crucian were female puberty. Based on the relation between the scale diameter and length and the information, linear relationship between crucian scale diameter and length: y=1.530+3.0649. From the data, the fertility and is closely relative to the increase of age. The older, the more mature gonad development. The more amount of eggs. In addition, absolute fecundity increases with the pituitary gland.Through quantitative check crucian bait food intake by the object, reveals the main food, secondary foods, and chance food of crucian ,and understand that crucian degree of be fond of of all kinds of bait organisms.Fish fertility with weight gain, it has the characteristics of species and populations, and at the same tmes influenced by the age of the individual, body length, body weight, environmental conditions (especially the nutrition conditions), and breeding habits, spawning times factors and the size of the egg. After a series of studies of crucian biological character, provide the ecological basis for local crucian's feeding, breeding

  2. Ex-ante analysis of economic returns from biological control of coconut mite in Tanzania

    NARCIS (Netherlands)

    Oleke, J.M.; Manyong, V.; Mignouna, D.; Isinika, A.; Mutabazi, K.; Hanna, R.; Sabelis, M.

    2013-01-01

    The coconut mite, Aceria guerreronis Keifer, has been identified as one of the pests that pose a threat to the coconut industry in Benin. The study presents the simulation results of the economic benefits of the biological control of coconut mites in Benin using a standard economic surplus model. In

  3. Physicochemical Characteristics and Biological Activity of Irradiated Pectin Solution

    International Nuclear Information System (INIS)

    Kwon, J.H.; Kang, H.J.; Jo, C.O.; Jeong, I.Y.; Byun, M.W.

    2005-01-01

    Pectin was dissolved in HCI, citric acid, and deionized distilled water (DW, 2%, v/v) and irradiated at different irradiation doses (2.5-50 kGy) by gamma ray to investigate its physicochemical characteristics and biological activity. Viscosity of pectin solution was significantly decreased by irradiation up to 10 kGy, then remained constant thereafter. Gamma-irradiation increased monosaccharide and polysaccharide levels up to 30-40 kDa. Electron donating ability of pectin solution was highest when DW was added was increased by increasing irradiation dose (p less than 0.05)

  4. A Study on the risk-return characteristics and the diversification benefit of the Hedge Fund industry

    OpenAIRE

    Bagaria, Neha

    2007-01-01

    Hedge funds with their dynamic trading strategies have gained great popularity in the past decade and have been found to provide significant diversification benefits to a traditional portfolio of assets. As an investment strategy they assure higher returns at a lower risk. Thus we will investigate its unique characteristics and its relation with the S&P 500 index through various quantitative tools like simple regression analysis, Sharpe ratios and graphical and correlation analysis of the dif...

  5. Macroscopic Biological Characteristics of Individualized Therapy in Chinese Mongolian Osteopathy

    Science.gov (United States)

    Namula, Zhao; Mei, Wang; Li, Xue-en

    Objective: Chinese Mongolian osteopathy has been passed down from ancient times and includes unique practices and favorable efficacy. In this study, we investigate the macroscopic biological characteristics of individualized Chinese Mongolian osteopathy, in order to provide new principle and methods for the treatment of bone fracture. Method: With a view to provide a vital link between nature and humans, the four stages of Chinese Mongolian osteopathy focus on the unity of the mind and body, the limbs and body organs, the body and its functions, and humans and nature. Results: We discuss the merits of individualized osteopathy in terms of the underlying concepts, and evaluate the approaches and principles of traditional medicine, as well as biomechanics. Conclusions: Individualized Mongolian osteopathy targets macroscopic biological components including dynamic reduction, natural fixation, and functional healing. Chinese Mongolian osteopathy is a natural, ecological and non-invasive osteopathy that values the link between nature and humans, including the unity of mind and body. The biological components not only serve as a foundation for Chinese Mongolian osteopathy but are also important for the future development of modern osteopathy, focusing on individualization, actualization and integration.

  6. Comparison of Venous Return Characteristics with Right Ventricular Mechanics During Cephalic Fluid Shift

    Science.gov (United States)

    Elliott, Morgan; Martin, David

    2015-01-01

    For my summer internship project, I organized a pilot study to analyze the effects of a cephalic fluid shift on venous return and right ventricular mechanics to increase right ventricular and venous knowledge. To accomplish this pilot study, I wrote a testing protocol, obtained Institutional Review Board (IRB) approval, completed subject payment forms, lead testing sessions, and analyzed the data. This experiment used -20deg head down tilt (20 HDT) as the ground based simulation for the fluid shift that occurs during spaceflight and compared it to data obtained from the seated and supine positions. Using echocardiography, data was collected for the right ventricle, hepatic vein, internal jugular vein, external jugular vein, and inferior vena cava. Additionally, non-invasive venous pressure measurements, similar to those soon to be done in-orbit, were collected. It was determined that the venous return from below the heard is increased during 20 HDT, which was supported by increased hepatic vein velocities, increased right ventricular inflow, and increased right ventricular strain at 20 HDT relative to seated values. Jugular veins in the neck undergo an increase in pressure and area, but no significant increase in flow, relative to seated values when a subject is tilted 20 HDT. Contrary to the initial expectations based on this jugular flow, there was no significant increase in central venous pressure, as evidenced by no change in Doppler indices for right arterial pressure or inferior vena cava diameter. It is suspected that these differences in pressure are due to the hydrostatic pressure indifference point shifting during tilt; there is a potential for a similar phenomenon with microgravity. This data will hopefully lead to a more in-depth understanding of the response of the body to microgravity and how those relate to the previously mentioned cardiovascular risk of fluid shift that is associated with spaceflight. These results were presented in greater detail

  7. Work Characteristics and Return to Work in Long-Term Sick-Listed Employees with Depressive Symptoms.

    Science.gov (United States)

    Huijs, Jenny J J M; Koppes, Lando L J; Taris, Toon W; Blonk, Roland W B

    2017-12-01

    Purpose The present study investigated the relations between work characteristics, depressive symptoms and duration until full return to work (RTW) among long-term sick-listed employees. This knowledge may add to the development of effective interventions and prevention, especially since work characteristics can be subjected to interventions more easily than many disorder-related or personal factors. Methods this prospective cohort study with a two-year follow-up employs a sample of 883 Dutch employees who had been sick-listed for at least 13 weeks at baseline, who filled out three questionnaires: at 19 weeks, 1 and 2 years after the start of sick leave. The dependent measure was duration until full RTW. Results not working (partially) at baseline, low decision authority, high psychological demands, low supervisor support and low RTW self-efficacy were related to more depressive symptoms. The duration until full RTW was longer for employees with depressive symptoms. Low physical exertion, high RTW self-efficacy, working partially at baseline, being married or cohabiting, and young age were related to less time until full RTW. Other work characteristics appeared no independent predictors of RTW. Conclusions although the role of job demands and job resources in the RTW process is limited for long-term sick-listed employees with depressive symptoms, a few work characteristics are prognostic factors of full RTW. Focus on these elements in the selection or development of interventions may be helpful in preventing sickness absence, and in supporting long-term sick-listed employees towards full RTW.

  8. Chemical and biological characteristics of Albion reef in the South ...

    African Journals Online (AJOL)

    The role of heterotrophic bacteria, pico-cyanobacteria and benthic cyanobacterial mats was assessed in the cycling of organic carbon and nitrogen in the Albion lagoon, Mauritius. Surveys and sampling for biological and chemical parameters were undertaken at three locations along one northern (T1) and one southern ...

  9. The Effects of High Frequency ULF Wave Activity on the Spectral Characteristics of Coherent HF Radar Returns

    Science.gov (United States)

    Wright, D. M.; Yeoman, T. K.; Woodfield, E. E.

    2003-12-01

    It is now a common practice to employ ground-based radars in order to distinguish between those regions of the Earth's upper atmosphere which are magnetically conjugate to open and closed field lines. Radar returns from ionospheric irregularities inside the polar cap and cusp regions generally exhibit large spectral widths in contrast to those which exist on closed field lines at lower latitudes. It has been suggested that the so-called Spectral Width Boundary (SWB) might act as a proxy for the open-closed field line boundary (OCFLB), which would then be an invaluable tool for investigating reconnection rates in the magnetosphere. The exact cause of the increased spectral widths observed at very high latitudes is still subject to considerable debate. Several mechanisms have been proposed. This paper compares a dusk-sector interval of coherent HF radar data with measurements made by an induction coil magnetometer located at Tromso, Norway (66° N geomagnetic). On this occasion, a series of transient regions of radar backscatter exhibiting large spectral widths are accompanied by increases in spectral power of ULF waves in the Pc1-2 frequency band. These observations would then, seem to support the possibility that high frequency magnetospheric wave activity at least contribute to the observed spectral characteristics and that such wave activity might play a significant role in the cusp and polar cap ionospheres.

  10. [Cell phone communication: hygienic characteristics, biological action, standardization (a review)].

    Science.gov (United States)

    Gudina, M V; Volkotrub, L P

    2010-01-01

    The paper considers the topical issues concerning the functioning of the cellular communication system. It provides the hygienic characteristics of its individual elements. The factors influencing the size of an electromagnetic field generated by mobile phones are stated. Research data on the impact of electromagnetic radiation from a mobile phone on users' health are reviewed. The pivots of present-day Russian hygienic rating regarding the permissible exposures to nonionizing electromagnetic energy generated by the elements of the cellular communication system are identified.

  11. Screening and biological characteristics of fufenozide degrading bacteria

    Science.gov (United States)

    Xu, Chenhao; Gong, Mingfu; Guan, Qinlan; Deng, Xia; Deng, Hongyan; Huang, Jiao

    2018-04-01

    Fufenozide was a novel pesticide for the control of Lepidoptera pests, which was highly toxic to silkworm. Fufenozide-contaminated soil samples were collected and the bacteria that degrade fufenozide were isolated and screened by selective medium. The colony characteristics, cell characteristics and degradation characteristics in different concentrations fufenozide of the fufenozide degrading bacteria were studied. The results indicated that seven strains of fufenozide degradeing bacteria, named as DDH01, DDH03, DDH04, DDH04, DDH05, DDH07 and DDH07 respectively, were isolated from soil contaminated with fufenozide. DDH01, DDH02, DDH04 and DDH05 of seven fufenozide degrading bacteria, was gram-positive bacteria, and DDH03, DDH06 and DDH07 was gram-negative bacteria. All of seven strains of fufenozide degrading bacteria were not spores, weeks flagella, rod-shaped bacteria. DDH06 and DDH07 had capsules, and the remaining five strains had not capsule. The colonies formed by seven strains of fufenozide degradation bacteria on beef extract peptone medium plate were milky white colonies with irregular edges, thinner lawn, smaller colony with smooth surface. The growth of 7 strains of fufenozide degradation bacteria was significantly affected by the concentration of fufenozide, All of 7 strains grown in the range from 0.00025 g/mL to 1 g/mL of 10% fufenozide suspension. DDH2 was the best among the 7 strains of fufenozide degrading bacteria grown in 10% fufenozide suspension medium.

  12. Evaluating the biological potential in samples returned from planetary satellites and small solar system bodies: framework for decision making

    National Research Council Canada - National Science Library

    National Research Council Staff; Space Studies Board; Division on Engineering and Physical Sciences; National Research Council; National Academy of Sciences

    ... from Planetary Satellites and Small Solar System Bodies Framework for Decision Making Task Group on Sample Return from Small Solar System Bodies Space Studies Board Commission on Physical Sciences, Mathematics, and Applications National Research Council NATIONAL ACADEMY PRESS Washington, D.C. 1998 i Copyrightthe true use are Please breaks...

  13. Biological and environmental characteristics of mangrove habitats from Manori creek, West Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Kulkarni, V.A.; Jagtap, T.G.; Mhalsekar, N.M.; Naik, A.N.

    better mangrove formations. A creek habitat had been evaluated for its biological and environmental characteristics, and is compared with similar but relatively lesser stressed Mandovi estuary (approx. 475 km south of Mumbai). Several evidences...

  14. Biological Characteristics and Control of Orobanche Crenata Forsk., a Review

    Directory of Open Access Journals (Sweden)

    Alessia Restuccia

    2009-03-01

    Full Text Available Orobanche crenata is a holoparasitic phanerogam which is particularly noxious to legumes, such as faba bean (Vicia faba L., pea (Pisum sativum L., chickpea (Cicer arietinum L., lentil (Lens culinaris Medik., etc., and commonly considered one of the major causes which has contributed to re-rizing the area designed to their cultivation. After a few brief references on the origin and diffusion of O. crenata, in this work summarises the results of research into biological aspects and control of this species. The information obtained especially concerns seed production, seed viability, seed longevity and dormancy, seed conditioning and germination, parasitism phases, the effects of parasite attacks on host plants and the means of control.

  15. Biological Characteristics and Control of Orobanche Crenata Forsk., a Review

    Directory of Open Access Journals (Sweden)

    Giuseppe Restuccia

    2011-02-01

    Full Text Available Orobanche crenata is a holoparasitic phanerogam which is particularly noxious to legumes, such as faba bean (Vicia faba L., pea (Pisum sativum L., chickpea (Cicer arietinum L., lentil (Lens culinaris Medik., etc., and commonly considered one of the major causes which has contributed to re-rizing the area designed to their cultivation. After a few brief references on the origin and diffusion of O. crenata, in this work summarises the results of research into biological aspects and control of this species. The information obtained especially concerns seed production, seed viability, seed longevity and dormancy, seed conditioning and germination, parasitism phases, the effects of parasite attacks on host plants and the means of control.

  16. Effect of low oxygen tension on the biological characteristics of human bone marrow mesenchymal stem cells

    OpenAIRE

    Kim, Dae Seong; Ko, Young Jong; Lee, Myoung Woo; Park, Hyun Jin; Park, Yoo Jin; Kim, Dong-Ik; Sung, Ki Woong; Koo, Hong Hoe; Yoo, Keon Hee

    2016-01-01

    Culture of mesenchymal stem cells (MSCs) under ambient conditions does not replicate the low oxygen environment of normal physiological or pathological states and can result in cellular impairment during culture. To overcome these limitations, we explored the effect of hypoxia (1 % O2) on the biological characteristics of MSCs over the course of different culture periods. The following biological characteristics were examined in human bone marrow-derived MSCs cultured under hypoxia for 8 week...

  17. Population characteristics of feral cats admitted to seven trap-neuter-return programs in the United States.

    Science.gov (United States)

    Wallace, Jennifer L; Levy, Julie K

    2006-08-01

    Internationally, large populations of feral cats constitute an important and controversial issue due to their impact on cat overpopulation, animal welfare, public health, and the environment, and to disagreement about what are the best methods for their control. Trap-neuter-return (TNR) programs are an increasingly popular alternative to mass euthanasia. The objective of this study was to determine the population characteristics of feral cats admitted to large-scale TNR programs from geographically diverse locations in the United States. Data from 103,643 feral cats admitted to TNR programs from 1993 to 2004 were evaluated. All groups reported more intact females (53.4%) than intact males (44.3%); only 2.3% of the cats were found to be previously sterilized. Overall, 15.9% of female cats were pregnant at the time of surgery. Pregnancy was highly seasonal and peaked between March and April for all of the groups. The average prenatal litter size was 4.1+/-0.1 fetuses per litter. Cryptorchidism was observed in 1.3% of male cats admitted for sterilization. A total of 0.4% of cats was euthanased because of the presence of debilitating conditions, and 0.4% died during the TNR clinics. Remarkably similar populations of cats with comparable seasonal variability were seen at each program, despite their wide geographical distribution. These results suggest that it is feasible to safely sterilize large numbers of feral cats and that the experiences of existing programs are a consistent source of information upon which to model new TNR programs.

  18. [Biological characteristics of the egg phase of citrus root weevils].

    Science.gov (United States)

    Guedes, Jerson V C; Parra, José R P

    2007-01-01

    The goal of this work was to study some characteristics of the egg phase of three species of citrus root weevils. The insects were collected from citrus plants in Itapetininga, SP, and brought to the Laboratório de Biologia de Insetos of ESALQ/USP, in Piracicaba, SP, where the species Naupactus cervinus (Boheman), Naupactus versatilis (Hustache) and Parapantomorus fluctuosus (Boheman) were kept. Duration and viability of the egg phase were evaluated, and the lower temperature threshold and thermal constant (K) were calculated for these species. The species of citrus root weevils showed different duration of egg phases. The egg phase ranged from 40.4 to 13.8 N. cervinus, from 38.7 to 20.0 days for N. versatilis, and from 35.0 to 13.8 days for P. fluctuosus, depending upon temperature. The temperature thresholds of this stage were 8.1, 8.3, and 9.9 masculineC at thermal constant was 385.7, 397.7 and 294.1 degree-days, for N. cervinus, N. versatilis and P. fluctuosus respectively. The duration of the egg phases of N. cervinus and N. versatilis were similar at the same temperatures and P. fluctuosus had a faster development than Naupactus spp. in all temperatures tested.

  19. The molecular biological characteristics of childhood thyroid carcinoma

    International Nuclear Information System (INIS)

    Cherstvoy, E; Nerovnya, A.; Voskoboinic, L.; Bogdanova, T.; Tronko, N.D.; Tonnachera, M.; Dumont, J.E.; Lamy, F.; Keller, G.; Boehm, J.; Hoefler, H.; Vecchio, G.C.; Viglietto, G.; Chiappetta, G.; Williams, G.H.; Thomas, G.A.; Williams, E.D.

    1996-01-01

    We have used molecular biology to study mutation and expression of key oncogenes in childhood thyroid carcinomas from Belarus and Ukraine. All cases were histologically verified by two or more pathologists including at least one from the CIS and one from the EU. We chose to study six genes which have been shown to be involved in thyroid carcinogenesis in adults: ret. Ha, Ki and N ras genes, p53 and the TSH receptor. Expression of the ret oncogene, which has been shown to be activated by translocation in a proportion of papillary carcinomas has been studied by two independent methods. The first, used by the Cambridge group uses RT-PCR to identify the expression of the tyrosine kinase domain of the gene; as the gene is normally silent in follicular cells, this approach allows demonstration of activation of ret, but does not identify the particular translocation involved. The second approach, used by the Naples group, also uses RT-PCR, but amplifies across the breakpoint of each of the three translocations already identified to provide information on the proportion of tumors which express the individual translocations of this gene. Mutations in the TSH receptor, a key modulator of thyroid follicular growth have been sought by the Brussels group using SSCP and direct sequencing. The Munich group have analyzed the samples for presence of mutation in p53, which is believed to play a role in genetic instability which is a features of carcinomas derived from may different tissues. Mutations in the common sites of the ras oncogenes have been studied by the Cambridge group. Analysis of 26 papillary carcinomas so far studied has shown that mutations in the TSH receptor and in p53 do not play a significant role in the genesis of the tumours studied. The proportion of tumours showing ret expression does not differ significantly from that found in a control non exposed population from the UK. However, the pathological study shows that nearly all the increased number of thyroid

  20. Anthropometric characteristics of young venezuelan swimmers by biological maturity status

    Directory of Open Access Journals (Sweden)

    Guillermo Ramírez

    2006-08-01

    Full Text Available There is limited information available on the maturation of child and adolescent athletes, considering that maturation is a factor that can affect performance. This study evaluates the anthropometry of 115 male Venezuelan swimmers (aged 7-17, at differing stages of biological maturity. The procedures employed adhere to International Society for the Advancement of Kinanthropometry guidelines. Tanner’s stages of genital maturation (G1-5 were used to subdivide the sample into the three categories posited by Nicoletti, prepuberty (G1, initial puberty (G2-3 and advanced puberty (G4-5. Forward stepwise discriminant analysis was performed, using increase in hit rate as the selection criterion. A total of 35 variables were evaluated, from which stretch stature, triceps skinfold, subscapular skinfold, calf girth, relaxed arm girth, body mass, forearm length and thigh length were selected. This set produced a high aggregate hit rate (87% of original grouped cases. Two linear discriminant functions (LDF1 and LDF2 emerged: LDF1 is capable of discriminating between prepuberty and advanced puberty and consists of stretch stature, body mass, forearm length, thigh length, relaxed arm circumference and calf circumference. LDF2 differentiates initial puberty from the other groups. This second set of discriminant variables comprises triceps skinfold and calf circumference. Confidence intervals demonstrate that two variables for body size, two for subcutaneous fatness, two for skeletal robustness and two for relative muscularity suffice to guide coaches when placing young swimmers into categories that best approximate the variability of maturation. Only triceps and subscapular skinfolds exhibited overlapping intervals in the three categories. RESUMO Existe limitada informação sobre a maturação de crianças e adolescentes atletas, uma vez que a maturação é um fator interveniente na performance. O presente estudo mensurou variáveis antropométricas de 115

  1. Effects of reduced return activated sludge flows and volume on anaerobic zone performance for a septic wastewater biological phosphorus removal system.

    Science.gov (United States)

    Magro, Daniel; Elias, Steven L; Randall, Andrew Amis

    2005-01-01

    Enhanced biological phosphorous removal (EBPR) performance was found to be adequate with reduced return-activated sludge (RAS) flows (50% of available RAS) to the anaerobic tank and smaller-than-typical anaerobic zone volume (1.08 hours hydraulic retention time [HRT]). Three identical parallel biological nutrient removal pilot plants were fed with strong, highly fermented (160 mg/L volatile fatty acids [VFAs]), domestic and industrial wastewater from a full-scale wastewater treatment facility. The pilot plants were operated at 100, 50, 40, and 25% RAS (percent of available RAS) flows to the anaerobic tank, with the remaining RAS to the anoxic tank. In addition, varying anaerobic HRT (1.08 and 1.5 hours) and increased hydraulic loading (35% increase) were examined. The study was divided into four phases, and the effect of these process variations on EBPR were studied by having one different variable between two identical systems. The most significant conclusion was that returning part of the RAS to the anaerobic zone did not decrease EBPR performance; instead, it changed the location of phosphorous release and uptake. Bringing less RAS to the anaerobic and more to the anoxic tank decreased anaerobic phosphorus release and increased anoxic phosphorus release (or decreased anoxic phosphorus uptake). Equally important is that, with VFA-rich influent wastewater, excessive anaerobic volume was shown to hurt overall phosphorus removal, even when it resulted in increased anaerobic phosphorus release.

  2. Mineralogical characteristics of the silica polymorphs in relation to their biological activities

    Energy Technology Data Exchange (ETDEWEB)

    Guthrie, G.D. Jr. [Los Alamos National Lab., NM (United States); Heaney, P.J. [Princeton Univ., NJ (United States). Dept. of Geological and Geophysical Sciences

    1993-10-01

    Numerous aspects of minerals (including the silica polymorphs) can effect their biological activities. These include periodic structures, compositional variations, dissolution characteristics, surface properties, and particle size/shape. In order to understand mineral-induced pathogenesis in a mechanistic way, the links between these properties and biochemical processes must be elucidated. This paper presents some of the basic properties of the silica polymorphs that may relate to pathogenicity and mineralogical strategies for designing biological assays to evaluate these properties.

  3. Crystallography of biological fluid as a method for evaluating its physicochemical characteristics.

    Science.gov (United States)

    Martusevich, A K; Kamakin, N F

    2007-03-01

    Using an integral qualitative and quantitative approach to the studies of initiation of the biological material crystallogenesis, we showed in experiments with normal human saliva that the external characteristics of biological fluid (pH, osmolality, and environmental temperature) determine the results of crystallization (tesigraphic facies). The main external (macroenvironment) and inner (microenvironment) factors of biological fluid crystal formation, determining specific features of the tesigraphic facies, were distinguished and classified. The informative value of differential analysis of biomaterial properties by means of modulating the environmental conditions is established.

  4. Biology, seed characteristics and growth establishment of comfrey (Symphytum officinale L.)

    OpenAIRE

    KOVÁŘOVÁ, Jaroslava

    2016-01-01

    The thesis titled "Biology, seed characteristics and growth establishment of common comfrey (Symphytum officinale L.)" dealt with the evaluation methods of reproduction comfrey and evaluation of the impact of environmental conditions to the grow of comfrey. Further it dealt with germination tests and their statistical evaluation while respecting the specific work with seeds. They were evaluated seed characteristics, which are reflected in the growth of these plants arising both in soil and in...

  5. Effect of low oxygen tension on the biological characteristics of human bone marrow mesenchymal stem cells.

    Science.gov (United States)

    Kim, Dae Seong; Ko, Young Jong; Lee, Myoung Woo; Park, Hyun Jin; Park, Yoo Jin; Kim, Dong-Ik; Sung, Ki Woong; Koo, Hong Hoe; Yoo, Keon Hee

    2016-11-01

    Culture of mesenchymal stem cells (MSCs) under ambient conditions does not replicate the low oxygen environment of normal physiological or pathological states and can result in cellular impairment during culture. To overcome these limitations, we explored the effect of hypoxia (1 % O 2 ) on the biological characteristics of MSCs over the course of different culture periods. The following biological characteristics were examined in human bone marrow-derived MSCs cultured under hypoxia for 8 weeks: proliferation rate, morphology, cell size, senescence, immunophenotypic characteristics, and the expression levels of stemness-associated factors and cytokine and chemokine genes. MSCs cultured under hypoxia for approximately 2 weeks showed increased proliferation and viability. During long-term culture, hypoxia delayed phenotypic changes in MSCs, such as increased cell volume, altered morphology, and the expression of senescence-associated-β-gal, without altering their characteristic immunophenotypic characteristics. Furthermore, hypoxia increased the expression of stemness and chemokine-related genes, including OCT4 and CXCR7, and did not decrease the expression of KLF4, C-MYC, CCL2, CXCL9, CXCL10, and CXCR4 compared with levels in cells cultured under normoxia. In conclusion, low oxygen tension improved the biological characteristics of MSCs during ex vivo expansion. These data suggest that hypoxic culture could be a useful method for increasing the efficacy of MSC cell therapies.

  6. Instructional Quality Features in Videotaped Biology Lessons: Content-Independent Description of Characteristics

    Science.gov (United States)

    Dorfner, Tobias; Förtsch, Christian; Boone, William; Neuhaus, Birgit J.

    2017-09-01

    A number of studies on single instructional quality features have been reported for mathematics and science instruction. For summarizing single instructional quality features, researchers have created a model of three basic dimensions (classroom management, supportive climate, and cognitive activation) of instructional quality mainly through observing mathematics instruction. Considering this model as valid for all subjects and as usable for describing instruction, we used it in this study which aimed to analyze characteristics of instructional quality in biology lessons of high-achieving and low-achieving classes, independently of content. Therefore, we used the data of three different previous video studies of biology instruction conducted in Germany. From each video study, we selected three high-achieving and three low-achieving classes (N = 18 teachers; 35 videos) for our multiple-case study, in which conspicuous characteristics of instructional quality features were qualitatively identified and qualitatively analyzed. The amount of these characteristics was counted in a quantitative way in all the videos. The characteristics we found could be categorized using the model of three basic dimensions of instructional quality despite some subject-specific differences for biology instruction. Our results revealed that many more characteristics were observable in high-achieving classes than in low-achieving classes. Thus, we believe that this model could be used to describe biology instruction independently of the content. We also make the claims about the qualities for biology instruction—working with concentration in a content-structured environment, getting challenged in higher order thinking, and getting praised for performance—that could have positive influence on students' achievement.

  7. Does mating interfere in the biological characteristics of a population of Trichogramma pretiosum?

    Directory of Open Access Journals (Sweden)

    DIRCEU PRATISSOLI

    2014-03-01

    Full Text Available Trichogramma spp. are parasitoids used in the regulation of insect populations that can cause economic damage. In order to ensure good performance, understanding some of their biological characteristics is essential. The objective of this study is to evaluate whether mating interferes with the biological characteristics of a population of Trichogramma pretiosum collected in the field. In all experiments, groups of mated and unmated females were used. We also verified any interference from mating on the biological characteristics of the offspring. We found that mating can alter the parasitism and longevity of genitor females, in addition to changing longevity among the descendants, but once parasitized, the eggs develop normally, showing similar emergence percentage and number of offspring as those from unmated females. In addition, we verified that the population of T. pretiosum collected in the field presented individuals with reproductive thelytokous and arrhenotokous characteristics. This fact highlights the importance of careful investigation on the reproduction mode of populations collected in the field, thus avoiding problems in the effective management of insect populations.

  8. Effects of space environment on biological characteristics of melanoma B16 cells

    International Nuclear Information System (INIS)

    Geng Chuanying; Xiang Qing; Xu Mei; Li Hongyan; Xu Bo; Fang Qing; Tang Jingtian; Guo Yupeng

    2006-01-01

    Objective: To examine the effects of space environment on biological characteristics of melanoma B16 Cells. Methods: B16 cells were carried to the space (in orbit for 8 days, circle the earth 286 times) by the 20th Chinese recoverable satellite, and then harvested and monocloned. 110 strains of space B16 cells were obtained in total. Ten strains of space B16 cells were selected and its morphological changes were examined with the phasecontrast microscope. Flow cytometry and MTT assay were carried out to evaluate the cell cycle and cell viability. Results Morphological changes were observed in the space cells, and melainin granules on the surface in some cells. It was demonstrated by MTF assay that space cells viability varied muti- directionally. It was showed by flow cytometry analysis that G1 phase of space cells was prolonged, S phase shortened. Conclusion: Space environment may change the biological characteristics of melanoma B16 cells. (authors)

  9. Effect of host and food availability on the biological characteristics of Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae)

    International Nuclear Information System (INIS)

    Pratissoli, Dirceu; Oliveira, Harley N. de; Oliveira, Regiane C. de; Zago, Hugo B.; Vieira, Stella M.J.

    2004-01-01

    Effect of host and food availability on the biological characteristics of Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae). Biological characteristics of Trichogramma galloi Zucchi, 1988 were evaluated in laboratory where these parasitoids were reared on eggs of Diatraea saccharalis (Lepidoptera, Pyralidae) with or without honey, and exposed to eggs of the host after 0, 6, 12, 24, 36, 48, 60, 72 and 84 hours of emergence. The parasitism rate and viability showed higher for individuals that received food. The sex ratio was not influenced by food. The number of individuals per egg only showed difference for those adults that did not receive food and stayed six hours without the host eggs. Checking the effect of the availability of eggs, only the sex ratio, with or without honey, did not show differences. The results show that T. galloi needs a carbohydrate supply and the time can influence the reproductive capacity. (author)

  10. Non-ionizing radiations : physical characteristics, biological effects and health hazard assessment

    International Nuclear Information System (INIS)

    Repacholi, M.H.

    1988-01-01

    The Workshop was a project of the International Non-Ionizing Radiation Committee of IRPA and comprised a series of educational lectures and demonstrations intended to give a comprehensive overview of non-ionizing electromagnetic radiation: physical characteristics, sources of concern, levels of exposure, mechanisms of interaction and reported effects of these fields and radiations with biological tissues, human studies, health risk assessment, national and international standards and guidelines, and protective measures

  11. Biological contaminants and house characteristics : an interim analysis of data from the PEI study

    Energy Technology Data Exchange (ETDEWEB)

    Onysko, D.M. [DMO Associates (Canada); Ruest, K. [Canada Mortgage and Housing Corp., Ottawa, ON (Canada); Lawton, M. [Morrison Hershfield Ltd., Ottawa, ON (Canada); Miller, D. [Carleton Univ., Ottawa, ON (Canada); Fraser, B. [Jacques Whitford and Associates Limited, Ottawa, ON (Canada); Dale, R. [Health Canada, Ottawa, ON (Canada); Kazimierz, K.F.

    2005-07-01

    This paper discussed the results of a joint study on housing conditions, biological exposure and the health of infants in Prince Edward Island (PEI). The study was a longitudinal cohort investigation of the exposure of infants to biological materials in their home environments. Possible associations between housing data, biological data, operational circumstances and relevant family life style information were presented. A methodology of the study was presented, in which a total of 366 dwellings with newborn infants were monitored over a period of 6 years. All tests and inspections were presented, as well as the nature of variables in the study. House investigations included the following: housing and operational characteristics; variables related to the measure of molds in the air; mold areas as determined by visual inspection; the presence/absence of visible molds; past wetting events; and concentrations of endotoxins, ergosterol and allergens in various air and settled dust samples. It was concluded that there was support for the presumption that some housing characteristics were related to factors that may influence the health of occupants and their children. Moisture related concerns dominated the experimental design. Details of the following housing characteristics were summarized: ground moisture source coupling; operation of the residence by the occupant; analysis of dust samples; visible molds; and wetting events. It was concluded that further work is needed to review the final database in order to further correlate studies with the health of newborns who lived in the houses studied. 3 refs., 8 tabs., 4 figs.

  12. Statistical Modeling of Radiative Transfer and Transient Characteristics for Multilayer Biological Tissue

    Directory of Open Access Journals (Sweden)

    S. Yu. Makarov

    2014-01-01

    Full Text Available The Monte-Carlo method [1] already long ago proved itself as a powerful and universal tool for mathematical modelling in various areas of science and engineering. Researchers often choose this method when it is difficult to find a solution by other ways (or impossible at all, e.g. because of sophisticated analytical dependences, area of modelling or boundary conditions. Certainly, this necessarily statistical and flexible method requires significant computation time, but a continuously increasing computation capability makes it more and more attractive for a choice in specific situation.One of the promising areas to use the method of statistical modelling is description of light propagation in the turbid (scattering media. A high motivation for development of this approach is widely used lasers in biomedicine [3]. Besides, owing to its flexibility, the Monte-Carlo method is also of importance in theoretical researches, in particular, to estimate a degree of adequacy of the offered approximation methods for solving a radiative transfer equation [4].It is known that key parameters of turbid media are an absorption coefficient (characterizes absorption probability of a photon per unit of path length and a scattering coefficient (characterizes scattering probability of a photon per unit of path length. The ratio of each of the coefficients to their sum (extinction defines a probability of "death" or "survival" of a photon, respectively, in interaction with lenses. Generally, in the scattering medium there is a non-coherent radiation component, which in turbid media such as biological tissues, already at the insignificant depth becomes prevailing over the coherent one (residual of the incident laser beam [5].The author used the Monte-Carlo method to simulate optical radiation propagation in the multilayer biological tissues with their optical characteristics corresponding to the skin and subcutaneous tissues. Such a biological tissue is the absorbing

  13. Effect of solids retention time and wastewater characteristics on biological phosphorus removal

    DEFF Research Database (Denmark)

    Henze, Mogens; Aspegren, H.; Jansen, J.l.C.

    2002-01-01

    with time which has importance in relation to modelling. The overall conclusion of the comparison between the two plants is that the biological phosphorus removal efficiency under practical operating conditions is affected by the SRT in the plant and the wastewater composition. Thus great care should......The paper deals with the effect of wastewater, plant design and operation in relation to biological nitrogen and phosphorus removal and the possibilities to model the processes. Two Bio-P pilot plants were operated for 2.5 years in parallel receiving identical wastewater. The plants had SRT of 4...... and 21 days, the latter had nitrification and denitrification. The plant with 4 days SRT had much more variable biomass characteristics, than the one with the high SRT. The internal storage compounds, PHA, were affected significantly by the concentration of fatty acids or other easily degradable organics...

  14. Degradation characteristics of 2,4-dichlorophenoxyacetic acid in electro-biological system

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, JingLi, E-mail: jinglizhangczp@126.com [Tianjin Key Laboratory of Aquatic Science and Technology, Tianjin Institute of Urban Construction, Tianjin 300384 (China); Cao, ZhanPing; Zhang, HongWei [School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387 (China); Zhao, LianMei [Tianjin Key Laboratory of Aquatic Science and Technology, Tianjin Institute of Urban Construction, Tianjin 300384 (China); Sun, XuDong; Mei, Feng [School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387 (China)

    2013-11-15

    Highlights: • The 2,4-D reductive degradation was studied in an electro-biological system. • The electric auxiliary accelerates 2,4-D microbial degradation. • A electron transfer is achieved between the electrode, bacteria and the pollutants. • The paper provides a promising way for the degradation of persistent organics. -- Abstract: The reductive degradation of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in an electro-biological system, a biological system and an electric catalytic system, respectively. Electrochemical characteristics were monitored by cyclic voltammetry and the intermediate products of 2,4-D degradation were determined by high speed liquid chromatography (HPLC). The results showed that all 2,4-D degradations in the three systems conformed to the kinetics characteristics of one-order reaction, and the degradation kinetics constants were 28.74 × 10{sup −2} h{sup −1}, 19.73 × 10{sup −2} h{sup −1} and 3.54 × 10{sup −2} h{sup −1}, respectively. The kinetics constant in the electro-biological system was higher than the sum in the other two systems by 19%. The electrochemical assistance provided the electrons and accelerated the electron transfer rate in the microbial degradation of 2,4-D. The degradation resulted from the microbial reduction strengthened by the electrochemical assistance. The electron transfer existed between the electrode, cytochrome, NAD and the pollutants. A long-range electron transfer process could be achieved on the multi-phase interfaces between the electrode, bacteria and the pollutants.

  15. Characteristics of health problems in returned overseas travelers at a tertiary teaching hospital in a suburban area in Japan.

    Science.gov (United States)

    Hirata, Kazuki; Ogawa, Taku; Fujikura, Hiroyuki; Ogawa, Yoshihiko; Hirai, Nobuyasu; Nakagawa-Onishi, Tomoko; Uno, Kenji; Takeyama, Masahiro; Kasahara, Kei; Nakamura-Uchiyama, Fukumi; Konishi, Mitsuru; Mikasa, Keiichi

    2018-03-01

    Few studies have analyzed the characteristics of patients who develop physical disorders after overseas travel. We retrospectively reviewed the medical records of 183 patients who visited Nara Medical University Hospital from 2008 to 2016 because of physical problems after traveling abroad. The main travel destinations were Southeast Asia (n = 100), Africa (n = 27), and South Asia (n = 23). The main reasons for the travel were leisure (n = 96), business (n = 51), and volunteer work (n = 19). The most common final diagnosis was gastrointestinal disease (n = 72), followed by febrile disease (n = 59) and respiratory disease (n = 19). There were eight malaria cases, including one patient who was infected after travel. Additionally, 61 of 71 cases of travelers' diarrhea and 15 of 21 cases of dengue fever occurred after travel. 26 cases of vaccine preventable diseases, such as hepatitis A, typhoid fever, and influenza, were observed. Consequently, healthcare providers should notify Japanese overseas travelers that there is a non-negligible health risk inherent to short-term travel, while stressing on the importance of pre-travel medical consultation. Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  16. Effect of repeated irradiation on biological characteristics of lung adenocarcinoma cell line Anip973 in vitro

    International Nuclear Information System (INIS)

    Xu Qingyong; Xu Xiangying; Yang Zhiwei

    2008-01-01

    Objective: To study the effect of repeated irradiation on biological characteristics of human lung adenocarcinoma cell line Anip973 in vitro. Methods: Anip973 cells were treated with high energy X-ray to a total dose of 60 Gy at 4 Gy fractions. The radiosensitivity of Anip973R and its parental cell were measured by clonogenic assay. The biological parameters were fitted to the single hit multitarget formula. Furthermore, the population double time(PDT) and cell cycle distribution were measured by cell growth curve and flow cytometry, respectively. Results: Comparing with its parental cell, Anip973 R acquired radioresistance showing increased D 0 , D q and SF 2 and a broader shoulder. PDT of Anip973R extended 3 h more than that of Anip973. The Anip973R also showed higher and lower percentage of cells in G 1 and S phase (P 2 /M distribution (P>0.05). Conclusions: A radioresistant lung adenocarcinoma cell line Anip973R is established by repeatedly irradiation. Its radioresistance displays obviously in lower dose area. However, its characteristic of cell cycle is not completely coincident with the classical radiobiological theory. (authors)

  17. Influence of volunteer and project characteristics on data quality of biological surveys.

    Science.gov (United States)

    Lewandowski, Eva; Specht, Hannah

    2015-06-01

    Volunteer involvement in biological surveys is becoming common in conservation and ecology, prompting questions on the quality of data collected in such surveys. In a systematic review of the peer-reviewed literature on the quality of data collected by volunteers, we examined the characteristics of volunteers (e.g., age, prior knowledge) and projects (e.g., systematic vs. opportunistic monitoring schemes) that affect data quality with regards to standardization of sampling, accuracy and precision of data collection, spatial and temporal representation of data, and sample size. Most studies (70%, n = 71) focused on the act of data collection. The majority of assessments of volunteer characteristics (58%, n = 93) examined the effect of prior knowledge and experience on quality of the data collected, often by comparing volunteers with experts or professionals, who were usually assumed to collect higher quality data. However, when both groups' data were compared with the same accuracy standard, professional data were more accurate in only 4 of 7 cases. The few studies that measured precision of volunteer and professional data did not conclusively show that professional data were less variable than volunteer data. To improve data quality, studies recommended changes to survey protocols, volunteer training, statistical analyses, and project structure (e.g., volunteer recruitment and retention). © 2015, Society for Conservation Biology.

  18. Biological characteristics of the hydrological landscapes in the Bay of Biscay in spring 2009

    KAUST Repository

    Lezama-Ochoa, Ainhoa; Grados, Daniel; Lebourges-Dhaussy, Anne; Irigoien, Xabier; Chaigneau, Alexis; Bertrand, Arnaud

    2015-01-01

    In the present study we investigated the biogeography of macrozooplankton and fish biomass in the Bay of Biscay. In this region, we defined six different landscapes based on the hydrogeographical characteristics observed in spring 2009. We then related landscape's characteristics and environmental parameters such as light attenuation depth and chlorophyll-a with macrozooplankton and fish acoustic biomass. Hydrodynamic structures together with coastal influences (river discharges, predation pressure and depth preference) and vertical thermohaline structure/mixing (feeding modes and ability to stay in preferred layers) appeared as the main factors determining the biological distribution. Besides, variance partitioning was used to assess the respective roles played by the hydrological environment, the geographical space and the biological environment alone, and their interactions. Results revealed that: (i) macrozooplankton and fish have a preference for different hydrogeographical landscapes; (ii) the association between hydrological conditions and geographical features, i.e. the spatial structure of the hydrological environment, plays a key role in the distribution of macrozooplankton; and (iii) prey-predator relationships have to be taken into account to provide a comprehensive characterization of habitat suitability.

  19. Biological characteristics of the hydrological landscapes in the Bay of Biscay in spring 2009

    KAUST Repository

    Lezama-Ochoa, Ainhoa

    2015-01-01

    In the present study we investigated the biogeography of macrozooplankton and fish biomass in the Bay of Biscay. In this region, we defined six different landscapes based on the hydrogeographical characteristics observed in spring 2009. We then related landscape\\'s characteristics and environmental parameters such as light attenuation depth and chlorophyll-a with macrozooplankton and fish acoustic biomass. Hydrodynamic structures together with coastal influences (river discharges, predation pressure and depth preference) and vertical thermohaline structure/mixing (feeding modes and ability to stay in preferred layers) appeared as the main factors determining the biological distribution. Besides, variance partitioning was used to assess the respective roles played by the hydrological environment, the geographical space and the biological environment alone, and their interactions. Results revealed that: (i) macrozooplankton and fish have a preference for different hydrogeographical landscapes; (ii) the association between hydrological conditions and geographical features, i.e. the spatial structure of the hydrological environment, plays a key role in the distribution of macrozooplankton; and (iii) prey-predator relationships have to be taken into account to provide a comprehensive characterization of habitat suitability.

  20. Pediatric High Grade Glioma: a Review and Update on Tumor Clinical Characteristics and Biology

    International Nuclear Information System (INIS)

    Fangusaro, Jason

    2012-01-01

    High grade gliomas (HGG) are one of the most common central nervous system (CNS) tumors encountered in adults, but they only represent approximately 8–12% of all pediatric CNS tumors. Historically, pediatric HGG were thought to be similar to adult HGG since they appear histologically identical; however, molecular, genetic, and biologic data reveal that they are distinct. Similar to adults, pediatric HGG are very aggressive and malignant lesions with few patients achieving long-term survival despite a variety of therapies. Initial treatment strategies typically consist of a gross total resection (GTR) when feasible followed by focal radiotherapy combined with chemotherapy. Over the last few decades, a wealth of data has emerged from basic science and pre-clinical animal models helping to better define the common biologic, genetic, and molecular make-up of these tumors. These data have not only provided a better understanding of tumor biology, but they have also provided new areas of research targeting molecular and genetic pathways with the potential for novel treatment strategies and improved patient outcomes. Here we provide a review of pediatric non-brainstem HGG, including epidemiology, presentation, histology, imaging characteristics, treatments, survival outcomes, and an overview of both basic and translational research. An understanding of all relevant pre-clinical tumor models, including their strengths and pitfalls is essential in realizing improved patient outcomes in this population.

  1. Pediatric High Grade Glioma: a Review and Update on Tumor Clinical Characteristics and Biology

    Energy Technology Data Exchange (ETDEWEB)

    Fangusaro, Jason, E-mail: jfangusaro@luriechildrens.org [Pediatric Neuro-Oncology, The Ann & Robert H. Lurie Children’s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL (United States)

    2012-08-24

    High grade gliomas (HGG) are one of the most common central nervous system (CNS) tumors encountered in adults, but they only represent approximately 8–12% of all pediatric CNS tumors. Historically, pediatric HGG were thought to be similar to adult HGG since they appear histologically identical; however, molecular, genetic, and biologic data reveal that they are distinct. Similar to adults, pediatric HGG are very aggressive and malignant lesions with few patients achieving long-term survival despite a variety of therapies. Initial treatment strategies typically consist of a gross total resection (GTR) when feasible followed by focal radiotherapy combined with chemotherapy. Over the last few decades, a wealth of data has emerged from basic science and pre-clinical animal models helping to better define the common biologic, genetic, and molecular make-up of these tumors. These data have not only provided a better understanding of tumor biology, but they have also provided new areas of research targeting molecular and genetic pathways with the potential for novel treatment strategies and improved patient outcomes. Here we provide a review of pediatric non-brainstem HGG, including epidemiology, presentation, histology, imaging characteristics, treatments, survival outcomes, and an overview of both basic and translational research. An understanding of all relevant pre-clinical tumor models, including their strengths and pitfalls is essential in realizing improved patient outcomes in this population.

  2. The chemical and biological characteristics of coke-oven wastewater by ozonation

    International Nuclear Information System (INIS)

    Chang, E.-E.; Hsing, H.-J.; Chiang, P.-C.; Chen, M.-Y.; Shyng, J.-Y.

    2008-01-01

    A bench-scale bubble column reactor was used to investigate the biological and chemical characteristics of coke-oven wastewater after ozonation treatment through the examination of selected parameters. Color and thiocyanate could be removed almost entirely; however, organic matter and cyanide could not, due to the inadequate oxidation ability of ozone to remove ozonated byproducts under given experimental conditions. The removal of cyanide and total organic carbon were pH-dependent and were found to be efficient under neutral to alkaline conditions. The removal rate for thiocyanate was about five times that of cyanide. The ozone consumption ratio approached to about 1 at the early stage of ozonation (time TOC ) increased to 30%, indicating that easily degraded pollutants were degraded almost entirely. The effect of ozonation on the subsequent biological treatment unit (i.e., activated sludge process) was determined by observing the ratio of 5-day biological oxygen demand to chemical oxygen demand (BOD 5 /COD) and the specific oxygen utilization rate (SOUR). The results indicated that the contribution of ozonation to inhibition reduction was very significant but limited to the enhancement of biodegradation. The operation for ozonation of coke-oven wastewater was feasible under neutral condition and short ozone contact time in order to achieve better performance and cost savings

  3. Correlation between mammographic findings and corresponding histopathology. Potential predictors for biological characteristics of breast diseases

    International Nuclear Information System (INIS)

    Tamaki, Kentaro; Ishida, Takanori; Miyashita, Minoru; Amari, Masakazu; Ohuchi, Noriaki; Tamaki, Nobumitsu; Sasano, Hironobu

    2011-01-01

    The present study retrospectively evaluated the mammographic findings of 606 Japanese women with breast cancer (median age 50 years; range 27-89 years) and correlated them with histopathological characteristics. Mammographic findings were evaluated with an emphasis on mass shape, margin, density, calcification, and the presence of architectural distortion; these findings were correlated with histopathological characteristics such as intrinsic subtype, histological grade, lymphovascular invasion, and the Ki-67 labeling index. An irregular mass shape and masses with a spiculated margin were significantly higher in the group of patients with luminal A breast cancer than in patients with masses that were lobular or round, or in tumors with an indistinct or microlobulated periphery (P=0.017, P=0.024, P<0.001, and P=0.001, respectively). Irregular mass shape and spiculated periphery were significantly lower in patients with Grade 3 cancer (P<0.001 for both). In terms of lymphovascular invasion, there were significant differences between oval and irregular or round mass shape (P=0.008 and P=0.034), between tumors with a microlobulated and indistinct periphery (P=0.014), between tumors with a punctate and amorphous or pleomorphic calcification shape (P=0.030 and 0.038), and between the presence and absence of architectural distortion (P=0.027). Equivalent or low-density masses were also higher in Grade 1 breast cancers (P=0.007). There were significant differences in the Ki-67 labeling index between irregular and lobular or round tumors (P<0.001 and P=0.014), as well as between spiculated and indistinct or microlobulated tumors (P<0.001 for both). Significant differences were noted in the mammographic features of different primary breast cancer subtypes. These proposed mammographic diagnostic criteria based on biological characteristics may contribute to a more accurate prediction of biological behavior of breast malignancies. (author)

  4. Characteristics of Nanoparticles in Drinking Water Treatment using Biological Activated Carbon

    Directory of Open Access Journals (Sweden)

    Desmiarti Reni

    2018-01-01

    Full Text Available Characteristics of nanoparticles in drinking water treatment were performed using five types of biological activated carbon (BAC columns (BAC1-BAC5 in continuous flow experiments. The BAC was created by covering granular activated carbon (GAC with attached microorganisms from water samples taken from the Nagara River in Japan. The total running time was about 2000 h. The characteristics of the nanoparticles were investigated based on size distribution and volume distribution measured by Zetasizer Nano. Total dissolved organic carbon (DOC and ultraviolet absorbance at 260 nm (UV260 were also studied. The important results in this study were that the detached nanoparticles in the effluent were within the size distribution ranges of 0.26~5.62 nm, 0.62~3.62 nm, 0.62~3.12 nm, 0.62~4.19 nm, and 0.62~6.50 for BAC 1, 2, 3, 4 and 5, respectively. The profile of peak size and peak number along the bed depth of the BAC columns was evaluated for better understanding the characteristics of the nanoparticles. This result is very important for improving drinking water treatment using granular activated carbon to remove microorganisms.

  5. Bacteriological examination and biological characteristics of deep frozen bone preserved by gamma sterilization

    International Nuclear Information System (INIS)

    Pham Quang Ngoc; Le The Trung; Vo Van Thuan; Ho Minh Duc

    1999-01-01

    To promote the surgical success in Vietnam, we should supply bone allografts of different sizes. For this reason we have developed a standard procedure in procurement, deep freezing, packaging and radiation sterilization of massive bone. The achievement in this attempt will be briefly reported. The dose of 10-15 kGy is proved to be suitable for radiation sterilization of massive bone allografts being treated in clean condition and preserved in deep frozen. Neither deep freezing nor radiation sterilization cause any significant loss of biochemical stability of massive bone allografts especially when deep freezing combines with radiation. There were neither cross infection nor change of biological characteristics found after 6 months of storage since radiation treatment. In addition to results of the previous research and development of tissue grafts for medical care, the deep freezing radiation sterilization has been established for preservation of massive bone that is of high demand for surgery in Vietnam

  6. Characteristics and evolution of the ecosystem of software tools supporting research in molecular biology.

    Science.gov (United States)

    Pazos, Florencio; Chagoyen, Monica

    2018-01-16

    Daily work in molecular biology presently depends on a large number of computational tools. An in-depth, large-scale study of that 'ecosystem' of Web tools, its characteristics, interconnectivity, patterns of usage/citation, temporal evolution and rate of decay is crucial for understanding the forces that shape it and for informing initiatives aimed at its funding, long-term maintenance and improvement. In particular, the long-term maintenance of these tools is compromised because of their specific development model. Hundreds of published studies become irreproducible de facto, as the software tools used to conduct them become unavailable. In this study, we present a large-scale survey of >5400 publications describing Web servers within the two main bibliographic resources for disseminating new software developments in molecular biology. For all these servers, we studied their citation patterns, the subjects they address, their citation networks and the temporal evolution of these factors. We also analysed how these factors affect the availability of these servers (whether they are alive). Our results show that this ecosystem of tools is highly interconnected and adapts to the 'trendy' subjects in every moment. The servers present characteristic temporal patterns of citation/usage, and there is a worrying rate of server 'death', which is influenced by factors such as the server popularity and the institutions that hosts it. These results can inform initiatives aimed at the long-term maintenance of these resources. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. Improvement of Soil Biology Characteristics at Paddy Field by System of Rice Intensification

    Directory of Open Access Journals (Sweden)

    Widyatmani Sih Dewi

    2015-07-01

    Full Text Available The aim of the research was to test the System of Rice Intensification (SRI method in improving the biological properties of paddy soil. The indicators of improvement were measured by the number of earthworm feces (cast, and the population of some microbial and nutrient content in the cast. The experiments were performed by comparing the three methods, namely: (1 SRI, (2 semi-conventional, and (3 conventional, using Randomized Completely Block Design. Each treatment was repeated nine times. The experiments were performed in the paddy fields belonging to farmers in Sukoharjo, Central Java. The result showed that the SRI (application of 1 tons ha-1 of vermicompost + 50% of inorganic fertilizer dosage tends to increase the number of earthworms cast. It is an indicator of earthworm activity in soil. Earthworms cast contains more phosphate solubilizing bacteria (12.98 x 1010cfu and N content (1.23% compared to its surrounding soil. There is a close functional relation between earthworms cast with total tiller number. SRI method is better than the other two methods to improve the biological characteristics of paddy soil that has the potential to maintain the sustainability of soil productivity.

  8. Eco-environment Restoration and Regional Differentiation Characteristics Based on “Building Terrace and Returning Slope Farmland to Forests and Grass”

    Institute of Scientific and Technical Information of China (English)

    Yanhua; LIU; Yong; XU

    2013-01-01

    Based on the scientific and technological achievements in the past decade in the Loess Hilly-gully Region and the successful demonstration experience in Yan’an Yangou watershed, we summarize the characteristics of eco-environment restoration pattern based on "building terrace and returning slope farmland to forests and grass". According to the data on land use, slope farmland and the agricultural population in 1999, we calculate the area of new terrace that needs to be built, the area of garden plot that needs to be extended, vegetation restoration area and investment demand in counties (cities, districts). Establishing and using some indicators, such as basic farmland extension indicator, garden plot extension indicator, vegetation restoration index and investment demand density, we conduct type classification and analysis of regional differentiation characteristics in 55 counties (cities, districts). The results show that in the Loess Hilly-gully Region, 691 600 hm2 of new terrace needs to be built, 792 000 hm2 of economic forests and orchards need to be extended, 5 410 200 hm2 of vegetation needs to be restored, and the total investment demand is 15.82 billion yuan; in terms of geographical distribution, obviously there are two key areas for eco-environment restoration (one is located in the border area between northern Shaanxi and northwestern Shanxi, and the other is located in the eastern Gansu and southern Ningxia area); the classified regional guidance policies should be formulated as soon as possible, and the limited funds should be concentrated in the key areas.

  9. [Development and succession of artificial biological soil crusts and water holding characteristics of topsoil].

    Science.gov (United States)

    Wu, Li; Chen, Xiao-Guo; Zhang, Gao-Ke; Lan, Shu-Bin; Zhang, De-Lu; Hu, Chun-Xiang

    2014-03-01

    In order to understand the improving effects of cyanobacterial inoculation on water retention of topsoil in desert regions, this work focused on the development and succession of biological soil crusts and water holding characteristics of topsoil after cyanobacterial inoculation in Qubqi Desert. The results showed that after the artificial inoculation of desert cyanobacteria, algal crusts were quickly formed, and in some microenvironments direct succession of the algal crusts to moss crusts occurred after 2-3 years. With the development and succession of biological soil crusts, the topsoil biomass, polysaccharides content, crust thickness and porosity increased, while the soil bulk density decreased. At the same time, with crust development and succession, the topsoil texture became finer and the percents of fine soil particles including silt and clay contents increased, while the percents of coarse soil particles (sand content) decreased proportionately. In addition, it was found that with crust development and succession, the water holding capacity and water content of topsoil showed an increasing trend, namely: moss crust > algal crusts > shifting sand. The water content (or water holding capacity) in algal and moss crusts were 1.1-1.3 and 1.8-2.2 times of those in shifting sand, respectively. Correlation analysis showed that the water holding capacity and water content of topsoil were positively correlated with the crust biomass, polysaccharides content, thickness, bulk density, silt and clay content; while negatively correlated with the porosity and sand content. Furthermore, stepwise regression analysis showed that the main factor affecting water content was the clay content, while that affecting water holding capacity was the porosity.

  10. Gold Returns

    OpenAIRE

    Robert J. Barro; Sanjay P. Misra

    2013-01-01

    From 1836 to 2011, the average real rate of price change for gold in the United States is 1.1% per year and the standard deviation is 13.1%, implying a one-standard-deviation confidence band for the mean of (0.1%, 2.1%). The covariances of gold's real rate of price change with consumption and GDP growth rates are small and statistically insignificantly different from zero. These negligible covariances suggest that gold's expected real rate of return--which includes an unobserved dividend yiel...

  11. Returning home

    DEFF Research Database (Denmark)

    Agergaard, Jytte; Brøgger, Ditte

    2016-01-01

    flows. By focusing on these educational migrants, this paper explores how they connect to their rural homes. Guided by a critical reading of the migration-development scholarship, the paper examines how migrants and their relatives make sense of educational migrants’ remitting and returning practices......, and by comparing three groups of educational migrants, the migrants’ reasons for staying connected and sending remittances are scrutinized. The paper finds that although educational migrants do not generate extensive economic remittances for local development in Nepal, they stay connected to their rural homes...

  12. BIOLOGICAL CHARACTERISTICS OF PIKE (ESOX LUCIUS LINNAEUS, 1758 OF THE LOWER DNIEPER RIVER IN CURRENT CONDITIONS

    Directory of Open Access Journals (Sweden)

    K. Geina

    2015-03-01

    Full Text Available Purpose. To analyze major biological characteristics of pike (Esox lucius L., 1758 stock in the lower Dnieper River in the conditions of transformed flow. Methodology. Collection of the ichthyological material was carried out in the lower Dnieper River from commercial fishing gears, including beach seines, drag seines, fyke-nets. Field, laboratory processing of samples and mathematical analysis of the obtained results were carried out according to generally accepted methods and guidelines with some assumptions regarding the duration of pike fattening directly in the lower Dnieper River. Findings. Recent years, there is an increase in the specific weight of younger age groups in the pike stock in the lower Dnieper River. Analysis of linear growth indicates on satisfactory environmental conditions for pike. Current commercial contingent of pike is based on size classes of 46–50 cm versus 22–32 cm in the first half of the last century. Reproductive properties of pike, in particular fecundity, egg size and maturity coefficients did not virtually change compared to those of the last century. Depending on linear sizes, the absolute fecundity is 32.3–155.8 thousand eggs and the maturation coefficient is 11.1–15.7%. Morphologic variability of pike in the lower Dnieper River during the period from 1980s to the present time was observed for plastic features, which characterized fin sizes. Sexual dimorphism in current conditions was observed only for maximum body depth. No significant differences for other plastic features between males and females of pike in the lower Dnieper River. Originality. The data on biological characteristics of pike stock from the lower Dnieper River have been updated. Current fecundity of females of different size groups recorded in commercial catches was been determined. An analysis of morphological variability of major plastic features of pike in the process of the transformation of the Dnieper River flow has been

  13. Work-specific cognitive symptoms and the role of work characteristics, fatigue and depressive symptoms in cancer patients during 18 months post return to work.

    Science.gov (United States)

    Dorland, H F; Abma, F I; Roelen, C A M; Stewart, R; Amick, B C; Bültmann, U; Ranchor, A V

    2018-06-19

    Cancer patients can experience work-specific cognitive symptoms post return to work (RTW). The study aims to: 1) describe the course of work-specific cognitive symptoms in the first 18 months post RTW, and 2) examine the associations of work characteristics, fatigue and depressive symptoms with work-specific cognitive symptoms over time. This study used data from the 18-months longitudinal "Work Life after Cancer" cohort. The Cognitive Symptom Checklist-Work, Dutch Version (CSC-W DV) was used to measure work-specific cognitive symptoms. Linear mixed models were performed to examine the course of work-specific cognitive symptoms during 18 months follow-up; linear regression analyses with generalised estimating equations (GEE) were used to examine associations over time. Working cancer patients diagnosed with different cancer types were included (n=378). Work-specific cognitive symptoms were stable over 18 months. At baseline, cancer patients reported more working memory symptoms (M=31.9, CI=23.1, 26.4) compared to executive function symptoms (M=19.3; CI=17.6, 20.9). Cancer patients holding a job with both manual and non-manual tasks reported less work-specific cognitive symptoms (unstandardized regression coefficient b=-4.80; CI=-7.76, -1.83) over time, compared to cancer patients with a non-manual job. Over time, higher depressive symptoms were related to experiencing more overall work-specific cognitive symptoms (b=1.27; CI=1.00, 1.55) and a higher fatigue score was related to more working memory symptoms (b=0.13; CI=0.04, 0.23). Job type should be considered when looking at work-specific cognitive symptoms over time in working cancer patients. To reduce work-specific cognitive symptoms, interventions targeted at fatigue and depressive symptoms might be promising. This article is protected by copyright. All rights reserved.

  14. Biological and phylogenetic characteristics of yellow fever virus lineages from West Africa.

    Science.gov (United States)

    Stock, Nina K; Laraway, Hewád; Faye, Ousmane; Diallo, Mawlouth; Niedrig, Matthias; Sall, Amadou A

    2013-03-01

    The yellow fever virus (YFV), the first proven human-pathogenic virus, although isolated in 1927, is still a major public health problem, especially in West Africa where it causes outbreaks every year. Nevertheless, little is known about its genetic diversity and evolutionary dynamics, mainly due to a limited number of genomic sequences from wild virus isolates. In this study, we analyzed the phylogenetic relationships of 24 full-length genomes from YFV strains isolated between 1973 and 2005 in a sylvatic context of West Africa, including 14 isolates that had previously not been sequenced. By this, we confirmed genetic variability within one genotype by the identification of various YF lineages circulating in West Africa. Further analyses of the biological properties of these lineages revealed differential growth behavior in human liver and insect cells, correlating with the source of isolation and suggesting host adaptation. For one lineage, repeatedly isolated in a context of vertical transmission, specific characteristics in the growth behavior and unique mutations of the viral genome were observed and deserve further investigation to gain insight into mechanisms involved in YFV emergence and maintenance in nature.

  15. Analysis of biological characteristics of corneal endothelium in old patients with high myopia

    Directory of Open Access Journals (Sweden)

    Ya-Qiong Chen

    2014-11-01

    Full Text Available AIM: To analyze quantitatively the biological characteristics of corneal endothelium in old patients of high myopia with non-contact automatic corneal endothelial microscope.METHODS:A total of 189 old patients(197 eyeswere divided into the high myopia group and the normal control group according to refractive diopter, in which the former 98 cases(103 eyes, the latter 91 cases(94 eyes. The hexagonal cell(6A, the coefficient of variation(CV, the average cell area(AVE, the average cell density(CDand the central corneal thickness(CCTwere measured by non-contact automatic corneal endothelium. SPSS 14.0 software was used to analyze their percentage. Z-test was used to compare the mean and Chi-square test was used to compare the rate in between. RESULTS: The average cell density in high myopia patients decreased, but there were 14 eyes >3 000/mm2, 11 eyes 2 and 78 eyes in the 2 000~3 000/mm2, there were each 0 eye, 3 eyes and 91 eyes respectively in the normal control group. There was statistically significant difference between high myopia group and control(χ2=19.11, PPP>0.05. CONCLUSION: There will provide a reference valuable for clinical surgeon. Because according to the changes of parameters and morphology of the corneal endothelial cells, we can understand the repair ability, to predict the consequence of the treatment, in order to determine the design and the choice of a surgical.

  16. [Influence of dendritic cell infiltration on prognosis and biologic characteristics of progressing gastric cancer].

    Science.gov (United States)

    Huang, Hai-li; Wu, Ben-yan; You, Wei-di; Shen, Ming-shi; Wang, Wen-ju

    2003-09-01

    To study the relation between dendritic cell (DC) infiltration and clinicopathologic parameters, biologic characteristics and prognosis of progressing gastric cancer. The development of apoptotic cell death (apoptotic index, AI) in 61 progressing gastric carcinoma tissues was analyzed by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick end labeling (TUNEL) method. The PCNA labeling index (PCNA-LI), density of dendritic cells in the tumor were detected by immunohistochemical method by the LSAB kit using antibody against S-100 protein and PC-10. DC infiltration was negatively correlated with lymph node metastasis, clinical stage and PCNA-LI, but positively with AI. The DCs in gastric cancer groups with and without lymph node metastasis were (5.63 +/- 4.37)/HPF and (8.51 +/- 5.57)/HPF with difference significant (P stage lesions were (11.23 +/- 6.05)/HPF, (6.28 +/- 4.37)/HPF and (5.53 +/- 5.19)/HPF also with differences significant (P gastric carcinoma.

  17. High voltage electric field effects on structure and biological characteristics of barley seeds

    Energy Technology Data Exchange (ETDEWEB)

    Khazaei, J. [Tehran Univ., Tehran (Iran, Islamic Republic of). Dept. of Agrotechnology, Univ. College of Abouraihan; Aliabadi, E. [Tehran Univ., Tehran (Iran, Islamic Republic of). Dept. of Crop Production Horticulture, Univ. College of Aburaihan; Shayegani, A.A. [Tehran Univ., Tehran (Iran, Islamic Republic of). Univ. College of Engineering

    2010-07-01

    Electric biostimulation of seeds is a pre-sowing treatment in which an electric field is applied to seeds to increase germination of non standard seeds. This paper reported on a study that examined the effects of AC electric field and exposure time on the structure and biological characteristics of barley seeds. The objective was to determine the potential to accelerate seed germination, plant growth and root development by the electric field strength and exposure time. Makooei cultivar barley seeds were used in this study. The effect of electric field strength (at 2, 4, 9, and 14 kV/m) and exposure time (at 15, 45, 80, and 150 min) on seed germination was studied along with height of seedling, length or root, height of stem, length of leaves, earliness, dry weight and wet weight of seedling. The treated seeds were stored for a month in a refrigerator at 5 degrees C prior to the germination experiments. The initial germination percent of the seed was 81 per cent. The treatment of barley seeds in an AC electric field had a positive effect on all investigated parameters. The germination percent of the treated seed increased to 94.5 per cent . The seeds exposed for long periods of time (45 to 150 min) showed better germination than the seeds exposed to lower exposure times. Dry and wet weights of seedling increased 143.4 per cent and 45.7 per cent, respectively.

  18. Drag Reduction and Performance Improvement of Hydraulic Torque Converters with Multiple Biological Characteristics

    Directory of Open Access Journals (Sweden)

    Liu Chunbao

    2016-01-01

    Full Text Available Fish-like, dolphin-like, and bionic nonsmooth surfaces were employed in a hydraulic torque converter to achieve drag reduction and performance improvement, which were aimed at reducing profile loss, impacting loss and friction loss, respectively. YJSW335, a twin turbine torque converter, was bionically designed delicately. The biological characteristics consisted of fish-like blades in all four wheels, dolphin-like structure in the first turbine and the stator, and nonsmooth surfaces in the pump. The prediction performance of bionic YJSW335, obtained by computational fluid dynamics simulation, was improved compared with that of the original model, and then it could be proved that drag reduction had been achieved. The mechanism accounting for drag reduction of three factors was also investigated. After bionic design, the torque ratio and the highest efficiencies of YJSW335 were both advanced, which were very difficult to achieve through traditional design method. Moreover, the highest efficiency of the low speed area and high speed area is 85.65% and 86.32%, respectively. By economic matching analysis of the original and bionic powertrains, the latter can significantly reduce the fuel consumption and improve the operating economy of the loader.

  19. Biological and physiological characteristics of Neotyphodium gansuense symbiotic with Achnatherum inebrians.

    Science.gov (United States)

    Li, Chunjie; Nan, Zhibiao; Li, Fei

    2008-01-01

    Biological and physiological characteristics of Neotyphodium gansuense were compared with Neotyphodium coenophialum and Epichloë festucae at a range of temperatures and pH values, and on carbon and nitrogen amended media. N. gansuense was able to grow at 10-30 degrees C, but not at 5 degrees C, and slowly at 35 degrees C. The optimal temperature for both N. gansuense and N. coenophialum was 25 degrees C, but that of E. festucae was 20-25 degrees C. The optimal pH ranges for mycelial growth of N. gansuense, N. coenophialum and E. festucae were 5-9, 5-9 and 5-7, respectively. The Neotyphodium and Epichloë endophytes varied in their ability to grow on media containing different carbon and nitrogen nutrients. The preference of N. gansuense for carbon source was sucrose>glucose, lactose, sorbitol, inulin, maltose, mannitol, starch, fructose>xylose. Growth of all three endophytes tested was significantly improved by peptone, tryptone, casein, yeast extract and l-proline. Yeast extract, peptone, casein, tryptone, l-proline, potassium nitrate, ammonium oxalic acid and l-leucine significantly improved growth of N. gansuense. However, ammonium nitrite was not utilized at all by any tested endophyte. N. gansuense grew significantly better on potato dextrose agar (PDA) and oat meal agar (OMA) than on corn meal agar (CMA) and drunken-horse-grass agar (DA), and most slowly on water agar (WA) and saltwater nutrient agar (SNA).

  20. Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation

    Directory of Open Access Journals (Sweden)

    Thiery Jean

    2005-05-01

    Full Text Available Abstract Background We have previously reported activating mutations of the gene coding for the fibroblast growth factor receptor 3 (FGFR3 in invasive cervical carcinoma. To further analyze the role of FGFR3 in cervical tumor progression, we extended our study to screen a total of 75 invasive tumors and 80 cervical intraepithelial neoplasias (40 low-grade and 40 high-grade lesions. Results Using single strand conformation polymorphism (SSCP followed by DNA sequencing, we found FGFR3 mutation (S249C in all cases in 5% of invasive cervical carcinomas and no mutation in intraepithelial lesions. These results suggest that, unlike in bladder carcinoma, FGFR3 mutation does not or rarely occur in non invasive lesions. Compared to patients with wildtype FGFR3 tumor, patients with S249C FGFR3 mutated tumors were older (mean age 64 vs. 49.4 years, P = 0.02, and were more likely to be associated with a non-16/18 HPV type in their tumor. Gene expression analysis demonstrated that FGFR3 mutated tumors were associated with higher FGFR3b mRNA expression levels compared to wildtype FGFR3 tumors. Supervised analysis of Affymetrix expression data identified a significant number of genes specifically differentially expressed in tumors with respect to FGFR3 mutation status. Conclusion This study suggest that tumors with FGFR3 mutation appear to have distinctive clinical and biological characteristics that may help in defining a population of patients for FGFR3 mutation screening.

  1. [Changes in active cysteine cathepsins in lysosomes from tissues thyroid papillary carcinomas with various biological characteristics].

    Science.gov (United States)

    Kalinichenko, O V; Myshunina, T M; Tron'ko, M D

    2013-01-01

    To clarify possible role of cysteine cathepsin H, B and L in the proteolytic processes that contribute to the progression of tumor growth in the thyroid, we studied their activity in lysosomes isolated from the tissue of papillary carcinomas. It was shown that for these enzymes there is a dependence of the changes in their activity on a number of biological characteristics of the tumors. Thus, the sharp increase in the activity ofcathepsin H observed in lysosomes of tissue carcinomas category T2 and T3, with intra-and ekstrathyroid and lymphatic invasion of tumor cells. An increase in the activity of cathepsin B is set in the lysosomes of tissue heterogeneous follicular structure, especially in the presence of solid areas, in comparison with typical papillary tumors and in the lysosomes of tissue carcinomas in intrathyroid and cathepsin L-at extrathyroid invasion. A common feature of the enzymes is to increase the activity of cathepsins in lysosomes of tissue nonencapsulated papillary carcinomas. These enzymes probably do not take part in the invasion of tumor cells into blood vessels and in the mechanisms of tumor metastasis to regional lymph nodes. The latter shows no changes in the activity of cathepsins in lysosomes of tissue carcinomas category N1. The results indicate the different role of cathepsin H, B and L in thyroid carcinogenesis, where each enzyme has its specific function.

  2. Comparison of biological characteristics of mesenchymal stem cells grown on two different titanium implant surfaces

    International Nuclear Information System (INIS)

    Wang Chengyue; Zhao Baohong; Ai Hongjun; Wang Yiwei

    2008-01-01

    This study examined the biological characteristics of mesenchymal stem cells (MSCs) grown on sand-blasted, large-grit, acid-etched (SLA) surface and hydroxyapatite (HA) coating on the SLA (HA/SLA) surface of titanium dental implants. The HA/SLA surfaces of titanium dental implants were formed by the ion beam assisted deposition (IBAD) method. Rabbit bone marrow derived mesenchymal stem cells cultured in vitro were seeded onto the surface of SLA and HA/SLA; the growth states of MSCs on the two samples were observed by a scanning electron microscope; the proliferation index, alkaline phosphatase (ALP) activity, osteocalcin (OCN) content of MSCs and mRNA relative expression level of osteopontin (opn) were compared between two groups. MSCs were found to be easier to adhere to the HA/SLA surface compared to the SLA surface. At the same time, the ALP activity and the OCN content of MSCs grown on the HA/SLA surface were obviously higher, and the relative expression level of opn mRNA was 4.78 times higher than that on the SLA surface. The HA coating formed by the IBAD method on the SLA surface of titanium dental implants significantly improves proliferation and well-differentiated osteoblastic phenotype of MSCs, which indicates a promising method for the surface modification of titanium dental implants

  3. Isolation, culture and biological characteristics of multipotent porcine skeletal muscle satellite cells.

    Science.gov (United States)

    Yang, Jinjuan; Liu, Hao; Wang, Kunfu; Li, Lu; Yuan, Hongyi; Liu, Xueting; Liu, Yingjie; Guan, Weijun

    2017-12-01

    Skeletal muscle has a huge regenerative potential for postnatal muscle growth and repair, which mainly depends on a kind of muscle progenitor cell population, called satellite cell. Nowadays, the majority of satellite cells were obtained from human, mouse, rat and other animals but rarely from pig. In this article, the porcine skeletal muscle satellite cells were isolated and cultured in vitro. The expression of surface markers of satellite cells was detected by immunofluorescence and RT-PCR assays. The differentiation capacity was assessed by inducing satellite cells into adipocytes, myoblasts and osteoblasts. The results showed that satellite cells isolated from porcine tibialis anterior were subcultured up to 12 passages and were positive for Pax7, Myod, c-Met, desmin, PCNA and NANOG but were negative for Myogenin. Satellite cells were also induced to differentiate into adipocytes, osteoblasts and myoblasts, respectively. These findings indicated that porcine satellite cells possess similar biological characteristics of stem cells, which may provide theoretical basis and experimental evidence for potential therapeutic application in the treatment of dystrophic muscle and other muscle injuries.

  4. CHARACTERISTIC FEATURES OF MUELLER MATRIX PATTERNS FOR POLARIZATION SCATTERING MODEL OF BIOLOGICAL TISSUES

    Directory of Open Access Journals (Sweden)

    E DU

    2014-01-01

    Full Text Available We developed a model to describe polarized photon scattering in biological tissues. In this model, tissues are simplified to a mixture of scatterers and surrounding medium. There are two types of scatterers in the model: solid spheres and infinitely long solid cylinders. Variables related to the scatterers include: the densities and sizes of the spheres and cylinders, the orientation and angular distribution of cylinders. Variables related to the surrounding medium include: the refractive index, absorption coefficient and birefringence. In this paper, as a development we introduce an optical activity effect to the model. By comparing experiments and Monte Carlo simulations, we analyze the backscattering Mueller matrix patterns of several tissue-like media, and summarize the different effects coming from anisotropic scattering and optical properties. In addition, we propose a possible method to extract the optical activity values for tissues. Both the experimental and simulated results show that, by analyzing the Mueller matrix patterns, the microstructure and optical properties of the medium can be obtained. The characteristic features of Mueller matrix patterns are potentially powerful tools for studying the contrast mechanisms of polarization imaging for medical diagnosis.

  5. Biological characteristics of silver bream (Blicca bjoerkna in commercial fishery in the Kyiv reservoir

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    I. Zakharchenko

    2016-12-01

    Full Text Available Purpose. The determination and analysis of main biological characteristics of silver bream from the point of view of the formation and exploitation of its commercial stock in the Kyiv reservoir. Methodology. The work is based the results of monitoring field studies carried out on the Kyiv reservoir during 2012–2014. Ichthyological materials were collected from standard commercial gill nets with mesh sizes of 30–80 mm, which were set in different habitats and depths of the reservoir. Collection and processing of samples was carried out using conventional ichthyological methods adapted for the Dnieper reservoirs. Findings. According to the data of monitoring gill nets, silver bream population in 2014 was composed of 10 age groups. The majority of their population (70.8% in catches was composed of age-5 to age-7 fish, i.e. the number of modal classes increased due to the right wing of the older age groups. The frequency distribution of silver bream had a shape of a curve with wide, however broken (due to the reduction in age-5 fish peak and gradual decrease. Age-length properties, fatness parameters and condition factor of silver bream in the Kiev reservoir during last years remained on the stable high level indicating on favorable fattening conditions and forming the ichthyomass of this species. At the present time, silver bream of the Kyiv reservoir formed a commercial stock with such qualitative and quantitative characteristics, which allow exploiting it in the mode of traditional commercial harvest and specialized harvest of silver bream concentrations with the use of gill nets with mesh sizes of 50, 60 mm. Originality. We obtained and analyzed the new data on the current state of silver bream (Blіcca bjoerkna in Kyiv reservoir as an important element of commercial fish production. Practical Value. The results of the work allows increasing qualitative and quantitative characteristics of silver bream catches and will be used for the

  6. Hygienic characteristics of working conditions and their influence on biological age of women occupied in modern wallpaper industry

    Directory of Open Access Journals (Sweden)

    Pichugina N.N.

    2011-06-01

    Full Text Available The article presents a complex sanitary characteristic of working conditions of women involved in wallpaper production. The main favorable factors of industrial environment have been determined. It is shown that working conditions in wallpaper production factories cause an increase in indices of biological age

  7. [Biological characteristics of mesenchymal stem cell and hematopoietic stem cell in the co-culture system].

    Science.gov (United States)

    Wei, Wei; Xu, Chao; Ye, Zhi-Yong; Huang, Xiao-Jun; Yuan, Jia-En; Ma, Tian-Bao; Lin, Han-Biao; Chen, Xiu-Qiong

    2016-10-25

    The aim of the present study was to obtain the qualified hematopoietic stem/progenitor cells (HSC/HPC) and human umbilical cord-mesenchymal stem cells (MSC) in vitro in the co-culture system. Cord blood mononuclear cells were separated from umbilical cord blood by Ficoll lymphocyte separation medium, and then CD34 + HSC was collected by MACS immunomagnetic beads. The selected CD34 + HSC/HPC and MSC were transferred into culture flask. IMDM culture medium with 15% AB-type cord plasma supplemented with interleukin-3 (IL-3), IL-6, thrombopoietin (TPO), stem cell factor (SCF) and FMS-like tyrosine kinase 3 ligand (Flt-3L) factors were used as the co-culture system for the amplification of HSC/HPC and MSC. The cellular growth status and proliferation on day 6 and 10 after co-culture were observed by using inverted microscope. The percentage of positive expression of CD34 in HSC/HPC, as well as the percentages of positive expressions of CD105, CD90, CD73, CD45, CD34 and HLA-DR in the 4 th generation MSC, was tested by flow cytometry. Semisolid colony culture was used to test the HSC/HPC colony forming ability. The osteogenic, chondrogenesis and adipogenic ability of the 4 th generation MSC were assessed. The karyotype analysis of MSC was conducted by colchicines. The results demonstrated that the HSC/HPC of co-culture group showed higher ability of amplification, CFU-GM and higher CD34 + percentage compared with the control group. The co-cultured MSC maintained the ability to differentiate into bone cells, fat cells and chondrocytes. And the karyotype stability of MSC remained normal. These results reveal that the appropriate co-culture system for MSC and HSC is developed, and via this co-culture system we could gain both two kinds of these cells. The MSCs under the co-culture system maintain the biological characteristics. The CFU-GM ability, cell counting and the flow cytometry results of HSC/HPC under the co-culture system are conform to the criterion, showing that

  8. The biological characteristics of anti-CD71 mouse/human chimeric antibody

    International Nuclear Information System (INIS)

    Wang Shuo; Jiang Lin; Lei Ping; Zhu Huifen; Shen Guanxin; Cui Wuren; Wang Yanggong

    2002-01-01

    Objective: To study the biological characteristics of an anti-CD71 mouse/human chimeric antibody (D2C). Methods: Analysis of the chimeric Ab production in culture supernatant was made by the standard concentration curve method with ELISA. The antibody was purified by DEAE-Sephredax-A50 ion-exchange chromatography and was confirmed by SDS-PAGE. The competition inhibition studies for binding to the same epitope on CD71 were performed between the chimeric Ab(D2C) in the culture supernatant was about 0.5-5 μg/ml in 5-day cultures when seeded at 1 x 10 5 cells/5ml compared with 12.5-25 μg/ml in the supernatant from their parental monoclonal Ab(7579). The purified chimeric Ab(D2C) from mouse ascetics was 1-2 mg/ml. The SDS-PAGE analysis of purified chimeric Ab(D2C) with discontinuous system confirmed two protein bands of 55 kDa and 25 kDa. It was clear that both chimeric Ab(D2C) and murine monoclonal Ab (7579) compete effectively to join the same epitope of CD71 each other. The chimeric antibody's affinity constant (Ka), quantitated by Scatchard analysis, is about 9.34-9.62 x 10 9 L/mol. Conclusion: The chimeric Ab(D2C) produced from the transfectomas is stable. The binding capacity of the chimeric Ab(D2C) to the antigen (CD71) was retained

  9. Preparation and biological characteristics of 99mTc-diol a renal agent

    International Nuclear Information System (INIS)

    Castanheira, I.; Paulo, A.; Neves, M.; Patricio, L.; Sawas-Dimopoulou, C.

    1993-01-01

    The present work concerns the production of 1,2-dihydroxypropyl-1-phosphonic acid (diol) by acid hydrolysis of (-cis) 1,2-epoxypropylphosphonic acid (phosphomycin), and its formation as a kit easily labeled with [ 99m Tc]pertechnetate. Biodistribution studies and whole-body autoradiographies in mice show that 99m Tc-diol has a specific affinity for the kidneys: it is rapidly cleared from the blood and excreted in urine. Part of the injected activity remains in the kidney cortex sufficiently long to permit kidney imaging. In comparison with other agents which also localize in the kidney cortex, such as 99m Tc-DMSA and 99m Tc-glucoheptonate ( 99m Tc-GHA), the main differences are the following: the peak of renal activity is reached early in the 5 min post-injection period for 99m Tc-diol, only at about 10 min post-injection for 99m Tc-GHA and after 3 h post-injection for 99m Tc-DMSA. The uptake of 99m Tc-diol by other organs, especially by bones, is much smaller than in the case of 99m Tc-DMSA. Unlike 99m Tc-DMSA, the biodistribution of 99m Tc-diol is not significantly influenced by acid-base imbalance. Moreover, the retention effect of hyperuricemia on 99m Tc-diol blood clearance and kidney excretion could be the result of a competition mechanism between this radiopharmaceutical and uric acid for a common transport system. The above biological characteristics suggest that 99m Tc-diol is a kidney radiopharmaceutical with an ability for functional and imaging studies. (author)

  10. Hydrological, morphometrical, and biological characteristics of the connecting rivers of the International Great Lakes: a review

    Science.gov (United States)

    Edwards, Clayton J.; Hudson, Patrick L.; Duffy, Walter G.; Nepszy, Stephen J.; McNabb, Clarence D.; Haas, Robert C.; Liston, Charles R.; Manny, Bruce; Busch, Wolf-Dieter N.; Dodge, D.P.

    1989-01-01

    The connecting channels of the Great Lakes are large rivers (1, 200-9, 900 m3 • s-1) with limited tributary drainage systems and relatively stable hydrology (about 2:1 ration of maximum to minimum flow). The rivers, from headwaters to outlet, are the St. Marys, St. Clair, Detroit, Niagara, and St. Lawrence. They share several characteristics with certain other large rivers: the fish stocks that historically congregated for spawning or feeding have been overfished, extensive channel modification have been made, and they have been used as a repository for domestic and industrial wastes and for hydroelectric energy generation. Levels of phosphorus, chlorophyll a, and particulate organic matter increase 3- to 5-fold from the St. Marys River to the St. Lawrence River. Biological communities dependent on nutrients in the water column, such as phytoplankton, periphyton, and zooplankton similarly increase progressively downstream through the system. The standing crop of emergent macrophytes is similar in all of the rivers, reflecting the relatively large nutrient pools in the sediments and atmosphere. Consequently, emergent macrophytes are an important source of organic matter (67% of total primary production) in the nutrient poor waters of the St. Marys River, whereas phytoplankton production dominates (76%) in the enriched St. Lawrence River. Submersed and emergent macrophytes and the associated periphyton are major producers of organic matter in the connecting channels. Another major source of organic matter (measured as ash free dry weight, AFDW) in the Detroit River is sewage, introduced at a rate of 26, 000 t per year. The production of benthos ranges from a low 5.4 g AFDW•m-2 in the Detroit River to a high of 15.5 g AFDW•m-2 in the St. Marys River. The rivers lack the organic transport from riparian sources upstream but receive large amounts of high quality phytoplankton and zooplankton from the Great Lakes.

  11. Characteristics of leachate in Foot and Mouth Disease Carcass Disposal using Molecular Biology Method

    Science.gov (United States)

    Choi, E. J.; Kim, B. J.; Wi, D. W.; Choi, N. C.; Lee, S. J.; Min, J. E.; Park, C. Y.

    2012-04-01

    The Leachate from Foot and Mouth Disease(FMD) carcass disposal by is one of the types of high-concentration contaminated wastewater with the greatest environmental impact. This is due to its pollutants: nitrate nitrogen (NO3--N) and pathogenic microorganisms. Satisfactory treatment of leachate is not an easy task for its high concentrations of nitrate nitrogen and pathogenic microorganisms. Therefore suitable FMD leachate treatment processes should be adopted to improve treatment performance and to reduce overall running costs. The objective of this study was to determine the leachate characteristics through environmental analysis and molecular biology method (bacteria identification and Polymerase Chain Reaction) using FMD leachate samples for optimal FMD leachate treatment processes. The Sixteen FMD leachate samples was obtained from carcass disposal regions in Korea. Results of environmental analysis showed that pH and Eh was observed from 5.57 to 7.40, -134~358mV. This data was exhibited typical early carcass disposal (Neutral pH and Reducing Environment by abundant organic matter). TOC and nitrate nitrogen high concentrations in FMD leachate showed a large variability from 2.3 to 38,730 mg/L(mean - 6,821.93mg/L) and 0.335 ~231.998mg/L(mean - 37.46mg/L), respectively. The result of bacteria identification was observed Bacillus cereus, Pseudomonas putida, Acinetobacter ursingii, Aeromonas hydrophila, Serratia liquefaciens, Brevundimonas naejangsanensis, Serratia liquefaciens, Pseudomonas fluorescens, Pseudomonas aeruginosa, Acinetobacter ursingii. The results of Polymerase Chain Reaction(PCR) using EzTaxon server data revealed Pseudoclavibacter helvolus, Pseudochrobactrum saccharolyticum, Corynebacterium callunae, Paenibacillus lautus, Paenibacillus sp., Bacillus arvi, Brevundimonas bullata, Acinetobacter ursingii, Lysinibacillus sphaericus, Bacillus pumilus, Bacillus sphaericus, Bacillus psychrodurans, Pseudomonas sp.

  12. Do biological and bedsite characteristics influence survival of neonatal white-tailed deer?

    Directory of Open Access Journals (Sweden)

    M Colter Chitwood

    Full Text Available Coyotes recently expanded into the eastern U.S. and potentially have caused localized white-tailed deer population declines. Research has focused on quantifying coyote predation on neonates, but little research has addressed the potential influence of bedsite characteristics on survival. In 2011 and 2012, we radiocollared 65 neonates, monitored them intensively for 16 weeks, and assigned mortality causes. We used Program MARK to estimate survival to 16 weeks and included biological covariates (i.e., sex, sibling status [whether or not it had a sibling], birth weight, and Julian date of birth. Survival to 16 weeks was 0.141 (95% CI = 0.075-0.249 and the top model included only sibling status, which indicated survival was lower for neonates that had a sibling. Predation was the leading cause of mortality (35 of 55; 64% and coyotes were responsible for the majority of depredations (30 of 35; 86%. Additionally, we relocated neonates for the first 10 days of life and measured distance to firebreak, visual obstruction, and plant diversity at bedsites. Survival of predation to 10 days (0.726; 95% CI = 0.586-0.833 was weakly associated with plant diversity at bedsites but not related to visual obstruction. Our results indicate that neonate survival was low and coyote predation was an important source of mortality, which corroborates several recent studies from the region. Additionally, we detected only weak support for bedsite cover as a covariate to neonate survival, which indicates that mitigating effects of coyote predation on neonates may be more complicated than simply managing for increased hiding cover.

  13. Influence of quality of care and individual patient characteristics on quality of life and return to work in survivors of the acute respiratory distress syndrome: protocol for a prospective, observational, multi-centre patient cohort study (DACAPO).

    Science.gov (United States)

    Brandstetter, Susanne; Dodoo-Schittko, Frank; Blecha, Sebastian; Sebök, Philipp; Thomann-Hackner, Kathrin; Quintel, Michael; Weber-Carstens, Steffen; Bein, Thomas; Apfelbacher, Christian

    2015-12-17

    Health-related quality of life (HRQoL) and return to work are important outcomes in critical care medicine, reaching beyond mortality. Little is known on factors predictive of HRQoL and return to work in critical illness, including the acute respiratory distress syndrome (ARDS), and no evidence exists on the role of quality of care (QoC) for outcomes in survivors of ARDS. It is the aim of the DACAPO study ("Surviving ARDS: the influence of QoC and individual patient characteristics on quality of life") to investigate the role of QoC and individual patient characteristics on quality of life and return to work. A prospective, observational, multi-centre patient cohort study will be performed in Germany, using hospitals from the "ARDS Network Germany" as the main recruiting centres. It is envisaged to recruit 2400 patients into the DACAPO study and to analyse a study population of 1500 survivors. They will be followed up until 12 months after discharge from hospital. QoC will be assessed as process quality, structural quality and volume at the institutional level. The main outcomes (HRQoL and return to work) will be assessed by self-report questionnaires. Further data collection includes general medical and ARDS-related characteristics of patients as well as sociodemographic and psycho-social parameters. Multilevel hierarchical modelling will be performed to analyse the effects of QoC and individual patient characteristics on outcomes, taking the cluster structure of the data into account. By obtaining comprehensive data at patient and hospital level using a prospective multi-centre design, the DACAPO-study is the first study investigating the influence of QoC on individual outcomes of ARDS survivors.

  14. More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls.

    Science.gov (United States)

    Lonsdorf, Tina B; Merz, Christian J

    2017-09-01

    Why do only some individuals develop pathological anxiety following adverse events? Fear acquisition, extinction and return of fear paradigms serve as experimental learning models for the development, treatment and relapse of anxiety. Individual differences in experimental performance were however mostly regarded as 'noise' by researchers interested in basic associative learning principles. Our work for the first time presents a comprehensive literature overview and methodological discussion on inter-individual differences in fear acquisition, extinction and return of fear. We tell a story from noise that steadily develops into a meaningful tune and converges to a model of mechanisms contributing to individual risk/resilience with respect to fear and anxiety-related behavior. Furthermore, in light of the present 'replicability crisis' we identify methodological pitfalls and provide suggestions for study design and analyses tailored to individual difference research in fear conditioning. Ultimately, synergistic transdisciplinary and collaborative efforts hold promise to not only improve our mechanistic understanding but can also be expected to contribute to the development of specifically tailored ('individualized') intervention and targeted prevention programs in the future. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. PEAR SHOOT SAWFLY (JANUS COMPRESSUS FABRICIUS – LIFE CYCLE AND BIOLOGICAL AND MORPHOLOGICAL CHARACTERISTIC

    Directory of Open Access Journals (Sweden)

    Tihomir Validžić

    2014-06-01

    Full Text Available The aim of the thesis was to investigate life cycle, biological and morphological characteristics of pear shoot sawfly (Janus compressus Fabricius, Hymenoptera Cephidae, furthermore to identify natural enemies in order to protect pear from this pest. The trial was conducted in the period of three years: 2010, 2011 and 2012 in pear orchards at five localities. Monitoring of adult sawfly was done by yellow sticky traps. Laboratory research was done at the Faculty of Agriculture, Department of Plant Protection, Section of Entomology and Nematology. In this study, pear shoot sawfly in Eastern Slavonia occurred in the period of four weeks, starting from the third decade of April with the peak population at the beginning of the May. Adults flight is the most intensive during warm and sunny days, when temperatures are above 14°C. Adult sawflies are characterized by elongated body and antennae, usually 7-12 mm long and sexual dimorphism is present. Pest is univoltine. Basic colour of adult sawfly is black. Antennae are moniliform and consist of 20 (male - 22 (female segments. Females have red or dark red colored abdomen, while males have yellow or orange one. Eggs are cylindrically shaped, 0.8-1.0 mm long. Female lays approximately 30 eggs. Embryonic development of pear shoot sawfly eggs lasts from 11 to 14 days. Larvae are 8-10 mm long, white or pale yellow. Larvae molt three times. Pear shoot sawfly larvae were parasitized by insects from Hymenoptera order, from five identified and one unidentified genera. Level of parasitism by genera is as follows: Eurytoma sp. (Hymenoptera: Eurytomidae – 9.83%, Tetrastichus sp. (Hymenoptera: Eulophidae – 2.01%, Eupelmus sp. (Hymenoptera: Eupelmidae – 1.66%, Pteromalus sp. (Hymenoptera: Pteromalidae – 0.55%, Ichneumonida sp. (Hymenoptera: Pimplinae – 0.35% and unidentified genera – 0.62%. Plant parasitic species Metopoplax origani (Hemiptera: Lygaeidae was found in 1.80% of analyzed shoots. Larvae were

  16. [Relationship among the Oxygen Concentration, Reactive Oxygen Species and the Biological Characteristics of Mouse Bone Marrow Hematopoietic Stem Cells].

    Science.gov (United States)

    Ren, Si-Hua; He, Yu-Xin; Ma, Yi-Ran; Jin, Jing-Chun; Kang, Dan

    2016-02-01

    To investigate the effects of oxygen concentration and reactive oxygen species (ROS) on the biological characteristics of hematopoietic stem cells (HSC) and to analyzed the relationship among the oxygen concentration, ROS and the biological characteristics of mouse HSC through simulation of oxygen environment experienced by PB HSC during transplantation. The detection of reactive oxygen species (ROS), in vitro amplification, directional differentiation (BFU-E, CFU-GM, CFU-Mix), homing of adhesion molecules (CXCR4, CD44, VLA4, VLA5, P-selectin), migration rate, CFU-S of NOD/SCID mice irradiated with sublethal dose were performed to study the effect of oxgen concentration and reactive oxygen species on the biological characteristics of mouse BM-HSC and the relationship among them. The oxygen concentrations lower than normal oxygen concentration (especially hypoxic oxygen environment) could reduce ROS level and amplify more Lin(-) c-kit(+) Sca-1(+) BM HSC, which was more helpful to the growth of various colonies (BFU-E, CFU-GM, CFU-Mix) and to maintain the migratory ability of HSC, thus promoting CFU-S growth significantly after the transplantation of HSC in NOD/SCID mice irradiated by a sublethal dose. BM HSC exposed to oxygen environments of normal, inconstant oxygen level and strenuously thanging of oxygen concentration could result in higher level of ROS, at the same time, the above-mentioned features and functional indicators were relatively lower. The ROS levels of BM HSC in PB HSCT are closely related to the concentrations and stability of oxygen surrounding the cells. High oxygen concentration results in an high level of ROS, which is not helpful to maintain the biological characteristics of BM HSC. Before transplantation and in vitro amplification, the application of antioxidancs and constant oxygen level environments may be beneficial for transplantation of BMMSC.

  17. Biological and ecological characteristics of Pterocuma pectinata (Malacostraca, Cumacea in Sasyk Reservoir

    Directory of Open Access Journals (Sweden)

    А. A. Khalaim

    2016-02-01

    Full Text Available Sasyk (Kunduk – estuary in the North-Western Black Sea region, is located 120 kmsouth-west of Odessa. In 1979–1980 Sasyk was separated from the sea by a dam, connected by a canal with the Danube and transformed into a reservoir. The fauna of Sasyk underwent significant changes and continues to adapt to the new conditions. This process is of great theoretical and practical interest. Cumacea – a small order, numbering about 600 species; is represented in the Black Sea-Azov basin by 23 species, 11 of them belong to the Caspian complex. Due to their high quantity indicators, they play a significant role in the diet of many species of fish. Pterocuma pectinata (Sowinski, 1893 is the most abundant species of cumacean not only in the Sasyk Reservoir, but also in many bodies of water in the region. However, the biology and ecology of this group of animals has been very inadequately studied. The material for these studies was provided by 120 benthic samples collected from 41 stations in the Sasyk Reservoir in the vegetation period 2013–2014. In this study we also used the material collected by means of H. Hungerford underwater light traps. In total 4,000 specimens of cumaceans were processed. This article shows the results of the studyof the post-embryonic development, fertility and size-mass characteristic of P. pectinata in Sasyk Reservoir. For both sexes for age stages have been distinguished and described for cumaceans: «manca», youth, prebreeding and breeding. Between breeding cycles, females live through one more preparatory (intermediate stage; the males die. This article provides a detailed morphological and morphometric description of all the stages of the ontogeny of cumaceans. The ratio of number of cumaceans at different stages of ontogeny varies considerably with the seasons. In the summer sexual development of cumacean occurs earlier than in the less warm seasons. A directly proportional relationship was found between body length

  18. Characteristic responses of biological and nanoscale systems in the terahertz frequency range

    Energy Technology Data Exchange (ETDEWEB)

    Angeluts, A A; Balakin, A V; Evdokimov, M G; Ozheredov, I A; Sapozhnikov, D A; Solyankin, P M; Shkurinov, A P [International Laser Center, M. V. Lomonosov Moscow State University, Moscow (Russian Federation); Esaulkov, M N; Nazarov, M M [Institute on Laser and Information Technologies, Russian Academy of Sciences, Shatura, Moscow Region (Russian Federation); Cherkasova, O P [Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk (Russian Federation)

    2014-07-31

    This paper briefly examines methods for the generation of pulsed terahertz radiation and principles of pulsed terahertz spectroscopy, an advanced informative method for studies of complex biological and nanostructured systems. Some of its practical applications are described. Using a number of steroid hormones as examples, we demonstrate that terahertz spectroscopy in combination with molecular dynamics methods and computer simulation allows one to gain information about the structure of molecules in crystals. A 'terahertz colour vision' method is proposed for analysis of pulsed terahertz signals reflected from biological tissues and it is shown that this method can be effectively used to analyse the properties of biological tissues and for early skin cancer diagnosis. (laser biophotonics)

  19. Effects of Intercropping on Biological Yield, Percentage of Nitrogen and Morphological Characteristics of Coriander and Fenugreek

    Directory of Open Access Journals (Sweden)

    R. Bigonah

    2014-12-01

    Full Text Available In order to study the intercropping arrangements of coriander (Coriandrum sativum L. and fenugreek (Trigonella foenum-graecum L., a field experiment was conducted during growing season of 2010 at Agriculture Research Station, College of Agriculture, Ferdowsi University of Mashhad, Iran. A randomized complete block design with three replications was used. Treatments included: mono-crop of fenugreek (A, %25 of optimum density of coriander + %175 of optimum density of fenugreek (B, %50 of optimum density of coriander + %150 of optimum density of fenugreek (C, %75 of optimum density of coriander + %125 of optimum density of fenugreek (D, %100 of optimum density of coriander + %100 of optimum density of fenugreek (E, mono-crop of coriander (F, %125 of optimum density of coriander + %75 of optimum density of fenugreek (G, %150 of optimum density of coriander + %50 of optimum density of fenugreek (H, %175 of optimum density of coriander + %25 of optimum density of fenugreek (I. Biological yield harvested in coriander at %5 flowering stage and in fenugreek at %20 flowering stage. The result showed that B treatment had highest plant height and biological yield of fenugreek, highest total land equivalent ratio and also B treatment had lowest essential oil contents of leaf, essential oil yield and biological yield of coriander. I treatment had lowest biological yield of fenugreek and it had highest essential oil contents of leaf, essential oil yield and plant height in coriander. Also A and E treatments had highest percent of nitrogen of biomass in fenugreek and coriander, respectively.

  20. [The influence of procaine electrophoresis and mesotherapy on the characteristics of biological age].

    Science.gov (United States)

    Turova, E A; Konchugova, T V; Balaban, E I; Fadeeva, N I; Golovach, A V; Teniaeva, E A

    2012-01-01

    The assessment of the biological age is needed to estimate the level of health and the efficacy of measures being undertaken to slow down the ageing processes and prolong the active life of the patients. Earlier studies have demonstrated the improvement of both physical health and psychic status of the elderly patients following intravenous administration of procaine. The objective of the present work was to evaluate effect of various methods of administration of a 2% procaine solution on the biological age. A total of 95 subjects at the age between 30 and 75 years were enrolled in the study. The procaine solutions were applied to the collar region. The patients of group 1 were treated with 2% procaine electrophoresis, those in group 2 with procaine galvanization with the same parameters. Mesotherapy using the 2% procaine solution was given to the patients of group 3. It was substituted by placebo (0.9% physiological solution) in the patients of group 4 (controls). The study revealed the most significant decrease of the biological age (calculated as described by L. M. Belozerova) in the patients treated with procaine electrophoresis (91% improvement). The mesotherapeutic administration of procaine also produced the beneficial effect (59% improvement). Neither procaine galvanization nor placebo mesotherapy caused any significant change of the variables characterizing the biological age.

  1. Concentration and characteristics of depleted uranium in biological and water samples collected in Bosnia and Herzegovina

    International Nuclear Information System (INIS)

    Jia Guogang; Belli, Maria; Sansone, Umberto; Rosamilia, Silvia; Gaudino, Stefania

    2006-01-01

    During Balkan conflicts in 1994-1995, depleted uranium (DU) ordnance was employed and was left in the battlefield. Health concern is related to the risk arising from contamination of the environment with DU penetrators and dust. In order to evaluate the impact of DU on the environment and population in Bosnia and Herzegovina, radiological survey of DU in biological and water samples were carried out over the period 12-24 October 2002. The uranium isotopic concentrations in biological samples collected in Bosnia and Herzegovina, mainly lichens, mosses and barks, were found to be in the range of 0.27-35.7 Bq kg -1 for 238 U, 0.24-16.8 Bq kg -1 for 234 U, and 0.02-1.11 Bq kg -1 for 235 U, showing uranium levels to be higher than in the samples collected at the control site. Moreover, the 236 U in some of the samples was detectable. The isotopic ratios of 234 U/ 238 U showed DU to be detectable in many biological samples at most sites examined, but in very low levels. The presence of DU in the biological samples was as a result of DU contamination in air. The uranium concentrations in water samples collected in Bosnia and Herzegovina were found to be in the range of 0.27-16.2 mBq l -1 for 238 U, 0.41-15.6 mBq l -1 for 234 U and 0.012-0.695 mBq l -1 for 235 U, and two water samples were observed to be DU positive; these values are much lower than those in mineral water found in central Italy and below the WHO guideline for public drinking water. From radiotoxicological point of view, at this moment there is no significant radiological risk related to these investigated sites in terms of possible DU contamination of water and/or plants

  2. Imprecision in estimates of dose from ingested 137Cs due to variability in human biological characteristics

    International Nuclear Information System (INIS)

    Schwarz, G.; Dunning, D.E. Jr.

    1982-01-01

    An attempt has been made to quantify the variability in human biological parameters determining dose to man from ingestion of a unit activity of soluble 137 Cs and the resulting imprecision in the predicted total-body dose commitment. The analysis is based on an extensive review of the literature along with the application of statistical methods to determine parameter variability, correlations between parameters, and predictive imprecision. The variability in the principal biological parameters (biological half-time and total-body mass) involved can be described by a geometric standard deviation of 1.2-1.5 for adults and 1.6-1.9 for children/ adolescents of age 0.1-18 yr. The estimated predictive imprecision (using a Monte Carlo technique) in the total-body dose commitment from ingested 137 Cs can be described by a geometric standard deviation on the order of 1.3-1.4, meaning that the 99th percentile of the predicted distribution of dose is within approximately 2.1 times the mean value. The mean dose estimate is 0.009 Sv/MBq (34 mrem/μ Ci) for children/adolescents and 0.01 Sv/MBq (38 mrem/μ Ci) for adults. Little evidence of age dependence in the total-body dose from ingested 137 Cs is observed. (author)

  3. Population Genetic Structure of Glycyrrhiza inflata B. (Fabaceae) Is Shaped by Habitat Fragmentation, Water Resources and Biological Characteristics.

    Science.gov (United States)

    Yang, Lulu; Chen, Jianjun; Hu, Weiming; Yang, Tianshun; Zhang, Yanjun; Yukiyoshi, Tamura; Zhou, Yanyang; Wang, Ying

    2016-01-01

    Habitat fragmentation, water resources and biological characteristics are important factors that shape the genetic structure and geographical distribution of desert plants. Analysis of the relationships between these factors and population genetic variation should help to determine the evolutionary potential and conservation strategies for genetic resources for desert plant populations. As a traditional Chinese herb, Glycyrrhiza inflata B. (Fabaceae) is restricted to the fragmented desert habitat in China and has undergone a dramatic decline due to long-term over-excavation. Determining the genetic structure of the G. inflata population and identifying a core collection could help with the development of strategies to conserve this species. We investigated the genetic variation of 25 G. inflata populations based on microsatellite markers. A high level of population genetic divergence (FST = 0.257), population bottlenecks, reduced gene flow and moderate genetic variation (HE = 0.383) were detected. The genetic distances between the populations significantly correlated with the geographical distances, and this suggests that habitat fragmentation has driven a special genetic structure of G. inflata in China through isolation by distance. STRUCTURE analysis showed that G. inflata populations were structured into three clusters and that the populations belonged to multiple water systems, which suggests that water resources were related to the genetic structure of G. inflata. In addition, the biological characteristics of the perennial species G. inflata, such as its long-lived seeds, asexual reproduction, and oasis ecology, may be related to its resistance to habitat fragmentation. A core collection of G. inflata, that included 57 accessions was further identified, which captured the main allelic diversity of G. inflata. Recent habitat fragmentation has accelerated genetic divergence. The population genetic structure of G. inflata has been shaped by habitat

  4. Assessing therapeutic relevance of biologically interesting, ampholytic substances based on their physicochemical and spectral characteristics with chemometric tools

    Science.gov (United States)

    Judycka, U.; Jagiello, K.; Bober, L.; Błażejowski, J.; Puzyn, T.

    2018-06-01

    Chemometric tools were applied to investigate the biological behaviour of ampholytic substances in relation to their physicochemical and spectral properties. Results of the Principal Component Analysis suggest that size of molecules and their electronic and spectral characteristics are the key properties required to predict therapeutic relevance of the compounds examined. These properties were used for developing the structure-activity classification model. The classification model allows assessing the therapeutic behaviour of ampholytic substances on the basis of solely values of descriptors that can be obtained computationally. Thus, the prediction is possible without necessity of carrying out time-consuming and expensive laboratory tests, which is its main advantage.

  5. The effects of urbanization on the biological, physical, and chemical characteristics of coastal New England streams

    Science.gov (United States)

    Coles, James F.; Cuffney, Thomas F.; McMahon, Gerard; Beaulieu, Karen M.

    2004-01-01

    During August 2000, responses of biological communities (invertebrates, fish, and algae), physical habitat, and water chemistry to urban intensity were compared among 30 streams within 80 miles of Boston, Massachusetts. Sites chosen for sampling represented a gradient of the intensity of urban development (urban intensity) among drainage basins that had minimal natural variability. In this study, spatial differences were used as surrogates for temporal changes to represent the effects of urbanization over time. The degree of urban intensity for each drainage basin was characterized with a standardized urban index (0-100, lowest to highest) derived from land cover, infrastructure, and socioeconomic variables. Multivariate and multimetric analyses were used to compare urban index values with biological, physical, and chemical data to determine how the data indicated responses to urbanization. Multivariate ordinations were derived for the invertebrate-, fish-, and algae-community data by use of correspondence analysis, and ordinations were derived for the chemical and physical data by use of principal-component analysis. Site scores from each of the ordinations were plotted in relation to the urban index to test for a response. In all cases, the primary axis scores showed the strongest response to the urban index, indicating that urbanization was a primary factor affecting the data ordination. For the multimetric analyses, each of the biological data sets was used to calculate a series of community metrics. For the sets of chemical and physical data, the individual variables and various combinations of individual variables were used as measured and derived metrics, respectively. Metrics that were generally most responsive to the urban index for each data set included: EPT (Ephemeroptera, Plecoptera, Trichoptera) taxa for invertebrates; cyprinid taxa for fish; diatom taxa for algae; bicarbonate, conductivity, and nitrogen for chemistry; and water depth and temperature

  6. BIOLOGICAL CHARACTERISTICS OF SLOVAK ISOLATES OF ENTOMOPATHOGENIC FUNGUS PANDORA NEOAPHIDIS (REMAUDIÈRE ET HENNEBERT HUMBER (ZYGOMYCETES, ENTOMOPHTHORALES

    Directory of Open Access Journals (Sweden)

    Marek BARTA

    2010-06-01

    Full Text Available Intraspecific variability of biological characteristics within entomopathogenic fungus Pandora neoaphidis was evaluated. Fifteen isolates of the fungus were obtained from 5 aphid species in Slovakia. Size of conidia, conidial germination, virulence, radial growth, and biomass production were evaluated. Conidial size varied considerably with exception of isolates originating from the same host population. Conidial germination was observed on all the surfaces tested and it was greatest at saturated humidity. Virulence, daily rate of radial growth and biomass production varied depending on isolates. Isolates obtained from the same host colonies during fungal epizootics shoved also significant differences in the characteristics, what may suggest that epizootics in aphid populations are caused by associations of strains and not by prevalence of a single virulent strain.

  7. Strontium incorporation to optimize the antibacterial and biological characteristics of silver-substituted hydroxyapatite coating

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Zhen; Cui, Zhenduo [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Li, Zhaoyang, E-mail: zyli@tju.edu.cn [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072 (China); Zhu, Shengli [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072 (China); Liang, Yanqin [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Liu, Yunde; Li, Xue; He, Xin; Yu, Xiaoxu; Wang, Renfeng [School of Laboratory Medicine, Tianjin Medical University, Tianjin 300072 (China); Yang, Xianjin, E-mail: xjyang@tju.edu.cn [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072 (China)

    2016-01-01

    Infection in primary total joint prostheses is attracting considerable attention. In this study, silver (Ag) was incorporated into hydroxyapatite (HA) using a hydrothermal method in order to improve its antimicrobial properties. Strontium (Sr) was added as a second binary element to improve the biocompatibility. The substituted HA samples were fixed on titanium (Ti) substrates by dopamine-assisted immobilization in order to evaluate their antibacterial and biological properties. The results showed that Ag and Sr were successfully incorporated into HA without affecting their crystallinity. Further, the antibacterial tests showed that all the Ag-substituted samples had good anti-bacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Despite their good antibacterial ability, the Ag-substituted samples showed evidence of cytotoxicity on MG63 cells, characterized by low cell density and poor spreadability. The addition of Sr to the Ag-substituted samples considerably reduced the cytotoxicity of Ag. Although the viability of the cells grown on the surfaces of co-substituted HA was not as high as that of the cells grown on the HA surfaces, it is believed that excellent antibacterial properties and good biological activity can be achieved by balancing the dosage of Sr and Ag. - Highlights: • Ag- and Sr-substituted HA was prepared by hydrothermal method. • Ag- and Sr-substituted HA coating was deposited on dopamine functionalized titanium. • Ag-substituted HA biofilm showed a remarkable antibacterial activity. • Sr could offset the side effects of Ag.

  8. Characteristics of microbial community functional structure of a biological coking wastewater treatment system.

    Science.gov (United States)

    Joshi, Dev Raj; Zhang, Yu; Zhang, Hong; Gao, Yingxin; Yang, Min

    2018-01-01

    Nitrogenous heterocyclic compounds are key pollutants in coking wastewater; however, the functional potential of microbial communities for biodegradation of such contaminants during biological treatment is still elusive. Herein, a high throughput functional gene array (GeoChip 5.0) in combination with Illumina HiSeq2500 sequencing was used to compare and characterize the microbial community functional structure in a long run (500days) bench scale bioreactor treating coking wastewater, with a control system treating synthetic wastewater. Despite the inhibitory toxic pollutants, GeoChip 5.0 detected almost all key functional gene (average 61,940 genes) categories in the coking wastewater sludge. With higher abundance, aromatic ring cleavage dioxygenase genes including multi ring1,2diox; one ring2,3diox; catechol represented significant functional potential for degradation of aromatic pollutants which was further confirmed by Illumina HiSeq2500 analysis results. Response ratio analysis revealed that three nitrogenous compound degrading genes- nbzA (nitro-aromatics), tdnB (aniline), and scnABC (thiocyanate) were unique for coking wastewater treatment, which might be strong cause to increase ammonia level during the aerobic process. Additionally, HiSeq2500 elucidated carbozole and isoquinoline degradation genes in the system. These findings expanded our understanding on functional potential of microbial communities to remove organic nitrogenous pollutants; hence it will be useful in optimization strategies for biological treatment of coking wastewater. Copyright © 2017. Published by Elsevier B.V.

  9. Biological characteristics that influence the SEUROP system classification for Czech fleckvieh and Holstein bull carcasses

    Directory of Open Access Journals (Sweden)

    Radek Filipčík

    2006-01-01

    Full Text Available The aim of this work was to analyse the influence of certain characteristics (aptitude, age, carcass weight, net daily gain, feeding on the final carcass classification in the SEUROP system. 703 Czech Fleckvieh bulls and 642 Holstein bulls were studied. The animals were slaughtered and evaluated at a designated beef processing company. Combine aptitude carcasses shown significant differences between characteristics. Remarkable differences of group averages (P>0, 01 were established between farms and they were due to various rearing conditions. Also the levels of net daily gain between aptitudes were proved significantly. Holstein breed showed significant difference among The net daily gain < 500 g.day–1 and levels 551–600; 601–650 and above 651 g.day–1. The SEUROP system is influenced the most by the feeding regime, which is described by a net daily gain in this work, and farm impact.

  10. Networks In Real Space: Characteristics and Analysis for Biology and Mechanics

    Science.gov (United States)

    Modes, Carl; Magnasco, Marcelo; Katifori, Eleni

    Functional networks embedded in physical space play a crucial role in countless biological and physical systems, from the efficient dissemination of oxygen, blood sugars, and hormonal signals in vascular systems to the complex relaying of informational signals in the brain to the distribution of stress and strain in architecture or static sand piles. Unlike their more-studied abstract cousins, such as the hyperlinked internet, social networks, or economic and financial connections, these networks are both constrained by and intimately connected to the physicality of their real, embedding space. We report on the results of new computational and analytic approaches tailored to these physical networks with particular implications and insights for mammalian organ vasculature.

  11. Toxins as biological weapons for terror-characteristics, challenges and medical countermeasures: a mini-review.

    Science.gov (United States)

    Berger, Tamar; Eisenkraft, Arik; Bar-Haim, Erez; Kassirer, Michael; Aran, Adi Avniel; Fogel, Itay

    2016-01-01

    Toxins are hazardous biochemical compounds derived from bacteria, fungi, or plants. Some have mechanisms of action and physical properties that make them amenable for use as potential warfare agents. Currently, some toxins are classified as potential biological weapons, although they have several differences from classic living bio-terror pathogens and some similarities to manmade chemical warfare agents. This review focuses on category A and B bio-terror toxins recognized by the Centers for Disease Control and Prevention: Botulinum neurotoxin, staphylococcal enterotoxin B, Clostridium perfringens epsilon toxin, and ricin. Their derivation, pathogenesis, mechanism of action, associated clinical signs and symptoms, diagnosis, and treatment are discussed in detail. Given their expected covert use, the primary diagnostic challenge in toxin exposure is the early detection of morbidity clusters, apart from background morbidity, after a relatively short incubation period. For this reason, it is important that clinicians be familiar with the clinical manifestations of toxins and the appropriate methods of management and countermeasures.

  12. Shear strength characteristics of mechanically biologically treated municipal solid waste (MBT-MSW) from Bangalore

    International Nuclear Information System (INIS)

    Sivakumar Babu, G.L.; Lakshmikanthan, P.; Santhosh, L.G.

    2015-01-01

    Highlights: • Shear strength properties of mechanically biologically treated municipal solid waste. • Effect of unit weight and particle size on the shear strength of waste. • Effect of particle size on the strength properties. • Stiffness ratio and the strength ratio of MSW. - Abstract: Strength and stiffness properties of municipal solid waste (MSW) are important in landfill design. This paper presents the results of comprehensive testing of shear strength properties of mechanically biologically treated municipal solid waste (MBT-MSW) in laboratory. Changes in shear strength of MSW as a function of unit weight and particle size were investigated by performing laboratory studies on the MSW collected from Mavallipura landfill site in Bangalore. Direct shear tests, small scale and large scale consolidated undrained and drained triaxial tests were conducted on reconstituted compost reject MSW samples. The triaxial test results showed that the MSW samples exhibited a strain-hardening behaviour and the strength of MSW increased with increase in unit weight. Consolidated drained tests showed that the mobilized shear strength of the MSW increased by 40% for a unit weight increase from 7.3 kN/m 3 to 10.3 kN/m 3 at 20% strain levels. The mobilized cohesion and friction angle ranged from 5 to 9 kPa and 8° to 33° corresponding to a strain level of 20%. The consolidated undrained tests exhibited reduced friction angle values compared to the consolidated drained tests. The friction angle increased with increase in the unit weight from 8° to 55° in the consolidated undrained tests. Minor variations were found in the cohesion values. Relationships for strength and stiffness of MSW in terms of strength and stiffness ratios are developed and discussed. The stiffness ratio and the strength ratio of MSW were found to be 10 and 0.43

  13. ANALYSIS OF INDIVIDUAL BIOLOGICAL CHARACTERISTICS OF AMUR CARP (CYPRINUS CARPIO HAEMATOPTERUS REPRODUCED USING CRYOPRESERVED SPERM

    Directory of Open Access Journals (Sweden)

    N. Kolisnyk

    2014-12-01

    Full Text Available Purpose. To reproduce Amur carp population using cryopreserved sperm and analyze some biological and fish culture peculiarities of the reproduced fish stock. Methodology. Generally accepted methods for fish culture [1]. Experimental reproduction was carried out in pond conditions of «Carpathian vodogray» LTD (Lisnevychi village, Pustomytivsky district, Lviv region. Hydrochemical analysis was carried out classically by O. Alуokin (1970 [2], hydrobiological studies in the fatting ponds according to V. Zhadin (1956, 1960 [3, 4]. Haemoglobin concentration was determined by hemocyanin method of G. Dervis, A. Vorobiov [5]. Blood for this method was collected from fish heart with the use of Pasteur pipettes in Eppendorf tubes with heparin. Following exterior morphometric parameters were analysed: body weight (m, g, standard fish body length (l, cm, largest body height (H, cm and body circumference (O cm. Following exterior indices were calculated based on these parameters: body depth index (l/H, body circumference index (l/O and Fulton’s condition factor (Kv. The study was carried out using two groups of carp: control and experimental. The first group was reproduced from the native sperm, the second from the cryopreserved sperm. Findings. Carp reproduction and growing was carried out using native and cryopreserved sperm. This work contains the results of growing 1+ Amur carp of experimental and control groups. Hydrochemical and hydrobiological parameters of the fattening ponds were studied. Peculiarities of the exterior and some hematological parameters of the carp of different origin were characterized. Originality. For the first time we performed a comparison of some biological parameters of Amur carp reproduced using native and cryopreserved sperm. Practical Value. Considering the economic importance of Amur carp due to its use in hybridization, reproduction of its population plays an important role in the development of the stocks of the pure

  14. Shear strength characteristics of mechanically biologically treated municipal solid waste (MBT-MSW) from Bangalore

    Energy Technology Data Exchange (ETDEWEB)

    Sivakumar Babu, G.L., E-mail: gls@civil.iisc.ernet.in [Department of Civil Engineering, Indian Institute of Science, Bangalore 560012 (India); Lakshmikanthan, P., E-mail: lakshmikanthancp@gmail.com [Centre for Sustainable Technologies (CST), Indian Institute of Science, Bangalore 560012 (India); Santhosh, L.G., E-mail: lgsanthu2006@gmail.com [Centre for Sustainable Technologies (CST), Indian Institute of Science, Bangalore 560012 (India)

    2015-05-15

    Highlights: • Shear strength properties of mechanically biologically treated municipal solid waste. • Effect of unit weight and particle size on the shear strength of waste. • Effect of particle size on the strength properties. • Stiffness ratio and the strength ratio of MSW. - Abstract: Strength and stiffness properties of municipal solid waste (MSW) are important in landfill design. This paper presents the results of comprehensive testing of shear strength properties of mechanically biologically treated municipal solid waste (MBT-MSW) in laboratory. Changes in shear strength of MSW as a function of unit weight and particle size were investigated by performing laboratory studies on the MSW collected from Mavallipura landfill site in Bangalore. Direct shear tests, small scale and large scale consolidated undrained and drained triaxial tests were conducted on reconstituted compost reject MSW samples. The triaxial test results showed that the MSW samples exhibited a strain-hardening behaviour and the strength of MSW increased with increase in unit weight. Consolidated drained tests showed that the mobilized shear strength of the MSW increased by 40% for a unit weight increase from 7.3 kN/m{sup 3} to 10.3 kN/m{sup 3} at 20% strain levels. The mobilized cohesion and friction angle ranged from 5 to 9 kPa and 8° to 33° corresponding to a strain level of 20%. The consolidated undrained tests exhibited reduced friction angle values compared to the consolidated drained tests. The friction angle increased with increase in the unit weight from 8° to 55° in the consolidated undrained tests. Minor variations were found in the cohesion values. Relationships for strength and stiffness of MSW in terms of strength and stiffness ratios are developed and discussed. The stiffness ratio and the strength ratio of MSW were found to be 10 and 0.43.

  15. Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology.

    Science.gov (United States)

    Guan, Jun-Jie; Niu, Xin; Gong, Fei-Xiang; Hu, Bin; Guo, Shang-Chun; Lou, Yuan-Lei; Zhang, Chang-Qing; Deng, Zhi-Feng; Wang, Yang

    2014-07-01

    Stem cells in human urine have gained attention in recent years; however, urine-derived stem cells (USCs) are far from being well elucidated. In this study, we compared the biological characteristics of USCs with adipose-derived stem cells (ASCs) and investigated whether USCs could serve as a potential cell source for neural tissue engineering. USCs were isolated from voided urine with a modified culture medium. Through a series of experiments, we examined the growth rate, surface antigens, and differentiation potential of USCs, and compared them with ASCs. USCs showed robust proliferation ability. After serial propagation, USCs retained normal karyotypes. Cell surface antigen expression of USCs was similar to ASCs. With lineage-specific induction factors, USCs could differentiate toward the osteogenic, chondrogenic, adipogenic, and neurogenic lineages. To assess the ability of USCs to survive, differentiate, and migrate, they were seeded onto hydrogel scaffold and transplanted into rat brain. The results showed that USCs were able to survive in the lesion site, migrate to other areas, and express proteins that were associated with neural phenotypes. The results of our study demonstrate that USCs possess similar biological characteristics with ASCs and have multilineage differentiation potential. Moreover USCs can differentiate to neuron-like cells in rat brain. The present study shows that USCs are a promising cell source for tissue engineering and regenerative medicine.

  16. Biological Characteristics of Caspase-14 and Its Expression in Neoplastic Diseases in the View of Translational Medicine

    Directory of Open Access Journals (Sweden)

    Kang-sheng LIU

    2016-06-01

    Full Text Available Caspase-14, a member of caspase family, only exists in mammals. As the most divergent member in the family of mammalian caspases, caspase-14 displays a variety of unique characteristics. It is expressed in a limited number of tissues and has the shortest amino acid sequence within the caspase protein family. At present, it has been found that caspase-14 is functionally different from the inflammatory reaction group of typical caspase family members. It exerts a certain effect in the promotion of final differentiation of epidermal cells and hydration of stratum corneum so as to maintain the steady state of skin barrier. In recent years, caspase-14 expression has been discovered in neoplastic diseases. Translational medicine integrates experimental research results and clinical guidance into the optimal implementation criteria for promoting the prediction, prevention and treatment of diseases. Via human genomics and molecular biology, translational medicine offers a possibility of screening molecular markers so that it can be used to diagnose the neoplastic diseases. In this article, the biological characteristics and substrates of caspase-14 as well as its expression in embryonic period and neoplastic diseases were reviewed.

  17. Influence of skin surface roughness degree on energy characteristics of light scattered by a biological tissue

    Science.gov (United States)

    Barun, V. V.; Ivanov, A. P.

    2017-05-01

    We present the results of modelling of photometric characteristics of light in soft tissues illuminated by a parallel beam along the normal to the surface, obtained with allowance for the skin roughness parameters and the angular structure of radiation approaching the surface from within the tissue. The depth structure of the fluence rate and the spectra of the diffuse reflection of light by the tissue in the interval of wavelengths 300 - 1000 nm are considered. We discuss the influence of the tilt angle variance of rough surface microelements and light refraction on the studied characteristics. It is shown that these factors lead to the reduction of the radiation flux only in the near-surface tissue layer and practically do not affect the depth of light penetration into the tissue. On the other hand, the degree of the surface roughness and the conditions of its illumination from within the tissue essentially affect the coefficient of diffuse reflection of light and lead to its considerable growth compared to the cases of a smooth interface and completely diffuse illumination, often considered to simplify the theoretical problem solution. The role of the roughness of skin surface is assessed in application to the solution of different direct and inverse problems of biomedical optics.

  18. Evolution of physical and biological characteristics of mesoscale eddy in north-central Red Sea

    KAUST Repository

    Zarokanellos, Nikolaos

    2015-04-01

    Eddies appear to be important to both the physical and biogeochemical dynamics of the Red Sea. Numerical simulations of physical dynamics and remote sensing studies of chlorophyll concentration and sea surface height in the Red Sea indicate their importance to the upper portions of the sea (Raitsos et al., 2013; Yao et al., 2014; Zhan et al., 2014). Despite their apparent importance, process studies of these eddies have been lacking. In March 2013 we began an extended observational study of the north-central Red Sea (NCRS) where anticyclonic eddies have been observed. The study began with a ship-based characterization of the eddy and was followed by a three-month observational time series using an autonomous glider equipped with a CTD, oxygen sensor, and optical sensors for chlorophyll, CDOM and optical backscatter. The ship-based study captured an initial snapshot of an anticyclonic eddy and it\\'s associated biological and bio-optical distributions. Initially, chlorophyll distributions tended to mirror the density distribution, with deeper isopycnals and chlorophyll maximum depth in the anticyclonic eddy center. The anticyclone eddy in March had an along basin diameter of 150 km, penetrated vertically less than 150 m and elevated near surface chlorophyll concentrations appeared along its outer boundary. The shallowing of the pycnocline of the outer boundaries of the anticyclone eddy on March may elevate nutrients into the lower euphotic zone, contributing to phytoplankton productivity and biomass within the eddy. This eddy contains most of the kinetic energy of the region with the maximum velocities up to 30 - 35 cm/s. The eddy appeared to interact with the coastal reefs where exchange particulate and dissolved matter may occur. The autonomous glider provided the spring-to-summer progression of the system with increasing stratification, shallowing of the subsurface chlorophyll maximum, and fluctuations in the position and intensity of the eddy. Our glider effort

  19. Test characteristics of two rapid antigen detection tests (SD FK50 and SD FK60 for the diagnosis of malaria in returned travellers

    Directory of Open Access Journals (Sweden)

    Van Esbroeck Marjan

    2009-05-01

    Full Text Available Abstract Background Two malaria rapid diagnostic tests were evaluated in a travel clinic setting: the SD FK50 Malaria Ag Plasmodium falciparum test (a two-band test and the SD FK60 Malaria Ag P. falciparum/Pan test (a three-band test. Methods A panel of stored whole blood samples (n = 452 and n = 614 for FK50 and FK60, respectively from returned travellers was used. The reference method was microscopy with PCR in case of discordant results. Results For both tests, overall sensitivity for the detection of P. falciparum was 93.5%, reaching 97.6% and 100% at parasite densities above 100 and 1,000/μl respectively. Overall sensitivities for Plasmodium vivax, Plasmodium ovale and Plasmodium malariae for the FK60 test were 87.5%, 76.3% and 45.2%, but they reached 92.6% and 90.5% for P. vivax and P. ovale at parasite densities above 500/μl. Specificities were above 95% for all species and both tests when corrected by PCR, with visible histidine-rich protein-2 lines for P. malariae (n = 3 and P. vivax and P. ovale (1 sample each. Line intensities were reproducible and correlated to parasite densities. The FK60 tests provided clues to estimate parasite densities for P. falciparum below or above 1,000/μl. Conclusion Both the FK50 and FK60 performed well for the diagnosis of P. falciparum in the present setting, and the FK60 for the diagnosis of P. vivax and P. ovale at parasite densities > 500/μl. The potential use of the FK60 as a semi-quantitative estimation of parasite density needs to be further explored.

  20. Factors determining differences in biological effectiveness of ionizing radiations possessing different physical characteristics

    International Nuclear Information System (INIS)

    Korogodin, V.I.; Krasavin, E.A.

    1982-01-01

    Radiosensitivity of pro- and eukaryotes (D 0- 1 ) is considered with regard to the linear energy transfer (LET) of ionizing radiations. It was shown that radiosensitivity, as a function of LET, D 0- 1 (LET), is determined by not merely physical characteristics of radiations but also the ability of repair of DNA double strand breaks (DSB). The increase in the radiosensitivity of eukaryotes is connected with the decrease in the DSB repair when cells are exposed to densely ionizing particles. The decrease in DSB repair is apparently connected with the increment of straight DSB, comparing to enzymatic DSB, upon exposure to heavy ions. Potential mechanisms of D 0- 1 (LET) modifications for radiosensitive and superresistant mutants are discussed

  1. The spatiotemporal dynamic analysis of the implied market information and characteristics of the correlation coefficient matrix of the international crude oil price returns

    International Nuclear Information System (INIS)

    Tian, Lixin; Ding, Zhenqi; Zhen, Zaili; Wang, Minggang

    2016-01-01

    The international crude oil market plays a crucial role in economies, and the studies of the correlation, risk and synchronization of the international crude oil market have important implications for the security and stability of the country, avoidance of business risk and people's daily lives. We investigate the information and characteristics of the international crude oil market (1999-2015) based on the random matrix theory (RMT). Firstly, we identify richer information in the largest eigenvalues deviating from RMT predictions for the international crude oil market; the international crude oil market can be roughly divided into ten different periods by the methods of eigenvectors and characteristic combination, and the implied market information of the correlation coefficient matrix is advanced. Secondly, we study the characteristics of the international crude oil market by the methods of system risk entropy, dynamic synchronous ratio, dynamic non-synchronous ratio and dynamic clustering algorithm. The results show that the international crude oil market is full of risk. The synchronization of the international crude oil market is very strong, and WTI and Brent occupy a very important position in the international crude oil market. (orig.)

  2. The spatiotemporal dynamic analysis of the implied market information and characteristics of the correlation coefficient matrix of the international crude oil price returns

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Lixin [Jiangsu University, Energy Development and Environmental Protection Strategy Research Center, Zhenjiang, Jiangsu (China); Nanjing Normal University, School of Mathematical Sciences, Nanjing, Jiangsu (China); Ding, Zhenqi; Zhen, Zaili [Jiangsu University, Energy Development and Environmental Protection Strategy Research Center, Zhenjiang, Jiangsu (China); Wang, Minggang [Nanjing Normal University, School of Mathematical Sciences, Nanjing, Jiangsu (China)

    2016-08-15

    The international crude oil market plays a crucial role in economies, and the studies of the correlation, risk and synchronization of the international crude oil market have important implications for the security and stability of the country, avoidance of business risk and people's daily lives. We investigate the information and characteristics of the international crude oil market (1999-2015) based on the random matrix theory (RMT). Firstly, we identify richer information in the largest eigenvalues deviating from RMT predictions for the international crude oil market; the international crude oil market can be roughly divided into ten different periods by the methods of eigenvectors and characteristic combination, and the implied market information of the correlation coefficient matrix is advanced. Secondly, we study the characteristics of the international crude oil market by the methods of system risk entropy, dynamic synchronous ratio, dynamic non-synchronous ratio and dynamic clustering algorithm. The results show that the international crude oil market is full of risk. The synchronization of the international crude oil market is very strong, and WTI and Brent occupy a very important position in the international crude oil market. (orig.)

  3. Physical and biological characteristics of the winter-summer transition in the Central Red Sea

    KAUST Repository

    Zarokanellos, Nikolaos

    2017-07-25

    The Central Red Sea (CRS) lies between two distinct hydrographic and atmospheric regimes. In the southern Red Sea, seasonal monsoon reversal regulates the exchange of water between the Red Sea and the Indian Ocean. In the northern Red Sea, intermediate and occasionally deep water are formed during winter to sustain the basin\\'s overturning circulation. Highly variable mesoscale eddies and the northward flowing eastern boundary current (EBC) determine the physical and biogeochemical characteristics of the CRS. Ship-based and glider observations in the CRS between March and June 2013 capture key features of the transition from winter to summer and depict the impact of the eddy activity on the EBC flow. Less saline and relatively warmer water of Indian Ocean origin reaches the CRS via the EBC. Initially, an anticyclonic eddy with diameter of 140 km penetrating to 150m depth with maximum velocities up to 30–35 cm s prevails in the CRS. This anticyclonic eddy appears to block or at least redirect the northward flow of the EBC. Dissipation of the eddy permits the near-coastal, northward flow of the EBC and gives place to a smaller cyclonic eddy with a diameter of about 50 km penetrating to 200 m depth. By the end of May, as the northerly winds become stronger and persistent throughout the basin, characteristic of the summer southwest monsoon wind regime, the EBC, and its associated lower salinity water became less evident, replaced by the saltier surface water that characterizes the onset of the summer stratification in the CRS.

  4. [Molecular-biological characteristic of Yersinia enterocolitica circulating in various regions of Russian Federation].

    Science.gov (United States)

    Karimova, T V; Bogumil'chik, E A; Voskresenskaia, E A; Klimov, V T; Tseneva, G Ia; Chesnokova, M V; Ivanov, L I; Poutonen, T B; Vasil'eva, A V; Gromova, T V

    2012-01-01

    Complex characteristic by phenotype signs and main virulence genes of Yersinia enterocolitica strains circulating in various regions of Russian Federation. 46 strains of Y. enterocolitica of 2 - 4 biotypes and 401 strains of Y. enterocolitica IA biotype isolated in 15 administrative territories of Russian Federation (Siberian, Far Eastern, Northwestern, Urals Federal Districts) from infected people, rodents, agricultural animals, birds, the environment were studied. Phagotyping was performed in the reference laboratory of the Pasteur Institute (Paris). All the Y. enterocolitica cultures were studied for the presence of ail, ystB and ystA genes by PCR method. Presence of virulence plasmid pYVwas determined by gel electrophoresis by T. Kieser method. 447 strains of Y. enterocolitica biotype 1A and 2 - 4 were studied. Most of the strains belonged to serotypes O:3; O:9; O: 5; O: 6,30; O:6,31; O:7,8. Phagotyping was performed for part of the strains. Phagotypes Xz and Xo were determined in biotype 1A strains. 2 - 4 biotype strains circulating in Siberia and the Far East were characterized by phagotype VIII, X3 that are present in other countries, and phagotype Xz that is spread only in Russia. Phagotypes IXa, IXb, II that are characteristic for strains from Canada, South Africa, Japan were not detected in Russian Federation. All the strains of 2 - 4 biotypes had ail and ystA genes. Most of the recently isolated strains had pYV. The only pathogenicity factor detected in 81.3% of biotype 1A strains including 14 strains from patients was ystB gene. These infections were accompanied by an expressed clinical symptomatology of enteritis and enterocolitis. Isolation of 1A biotype strains from patients necessitates execution of diagnostic studies of intestinal yersiniosis in patients with diagnosis "acute intestinal infection of undetermined etiology".

  5. Biological characteristics of genetic variants of Urabe AM9 mumps vaccine virus.

    Science.gov (United States)

    Wright, K E; Dimock, K; Brown, E G

    2000-03-01

    The Urabe AM9 mumps vaccine is composed of a mixture of variants distinguishable by a difference at nucleotide (nt) 1081 of the hemagglutinin-neuraminidase (HN) gene (Brown, E.G., Dimock, K., Wright, K.E., 1996. The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid (aa) 335 of the hemagglutinin-neuraminidase gene with one form associated with disease. J. Infect. Dis. 174, 619-622.). Further genetic and biological variation was detected in plaque purified viruses from the Urabe AM9 vaccine by examining the HN gene sequence, plaque morphology, cytopathic effects and growth in Vero cells, and temperature sensitivity (ts). Infection of Vero cells with plaque purified viruses with a G at nt 1081 of the HN gene produced large, clear plaques, caused significant CPE early after infection but yielded lower titres of virus than other purified viruses. None of these viruses were ts. In contrast, half of the plaque purified viruses with an A at nt 1081 were sensitive to a temperature of 39.5 degrees C. These viruses produced small plaques, caused significant CPE and grew to low titres. Two ts viruses possessed a unique aa substitution at aa 468 of HN. The remaining A(1081) viruses were not ts, produced large plaques but little CPE, and grew to titres 10-fold higher than the G(1081) viruses. Isolates of Urabe AM9 associated with post-vaccination illness were similar to these non-ts A(1081) viruses, but could be further sub-divided into two groups on the basis of a difference at aa 464 of HN. The post-vaccination isolates may represent insufficiently attenuated components of the vaccine, while the G(1081) and ts subset of A(1081) viruses may be more fully attenuated.

  6. Biological characteristics of human menstrual blood-derived endometrial stem cells.

    Science.gov (United States)

    Liu, Yanli; Niu, Rongcheng; Yang, Fen; Yan, Yan; Liang, Shengying; Sun, Yuliang; Shen, Ping; Lin, Juntang

    2018-03-01

    Successful isolation of human endometrial stem cells from menstrual blood, namely menstrual blood-derived endometrial stem cells (MenSCs), has provided enticing alternative seed cells for stem cell-based therapy. MenSCs are enriched in the self-regenerative tissue, endometrium, which shed along the periodic menstrual blood and thus their acquisition involves no physical invasiveness. However, the impact of the storage duration of menstrual blood prior to stem cell isolation, the age of the donor, the number of passages on the self-renewing of MenSCs, the paracrine production of biological factors in MenSCs and expression of adhesion molecules on MenSCs remain elusive. In this study, we confirmed that MenSCs reside in shedding endometrium, and documented that up to 3 days of storage at 4°C has little impact on MenSCs, while the age of the donor and the number of passages are negatively associated with proliferation capacity of MenSCs. Moreover, we found that MenSCs were actually immune-privileged and projected no risk of tumour formation. Also, we documented a lung- and liver-dominated, spleen- and kidney-involved organic distribution profile of MenSC 3 days after intravenous transfer into mice. At last, we suggested that MenSCs may have potentially therapeutic effects on diseases through paracrine effect and immunomodulation. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  7. Using redescription mining to relate clinical and biological characteristics of cognitively impaired and Alzheimer's disease patients.

    Directory of Open Access Journals (Sweden)

    Matej Mihelčić

    Full Text Available Based on a set of subjects and a collection of attributes obtained from the Alzheimer's Disease Neuroimaging Initiative database, we used redescription mining to find interpretable rules revealing associations between those determinants that provide insights about the Alzheimer's disease (AD. We extended the CLUS-RM redescription mining algorithm to a constraint-based redescription mining (CBRM setting, which enables several modes of targeted exploration of specific, user-constrained associations. Redescription mining enabled finding specific constructs of clinical and biological attributes that describe many groups of subjects of different size, homogeneity and levels of cognitive impairment. We confirmed some previously known findings. However, in some instances, as with the attributes: testosterone, ciliary neurotrophic factor, brain natriuretic peptide, Fas ligand, the imaging attribute Spatial Pattern of Abnormalities for Recognition of Early AD, as well as the levels of leptin and angiopoietin-2 in plasma, we corroborated previously debatable findings or provided additional information about these variables and their association with AD pathogenesis. Moreover, applying redescription mining on ADNI data resulted with the discovery of one largely unknown attribute: the Pregnancy-Associated Protein-A (PAPP-A, which we found highly associated with cognitive impairment in AD. Statistically significant correlations (p ≤ 0.01 were found between PAPP-A and clinical tests: Alzheimer's Disease Assessment Scale, Clinical Dementia Rating Sum of Boxes, Mini Mental State Examination, etc. The high importance of this finding lies in the fact that PAPP-A is a metalloproteinase, known to cleave insulin-like growth factor binding proteins. Since it also shares similar substrates with A Disintegrin and the Metalloproteinase family of enzymes that act as α-secretase to physiologically cleave amyloid precursor protein (APP in the non-amyloidogenic pathway

  8. Soil Physical Characteristics and Biological Indicators of Soil Quality Under Different Biodegradable Mulches

    Science.gov (United States)

    Schaeffer, S. M.; Flury, M.; Sintim, H.; Bandopadhyay, S.; Ghimire, S.; Bary, A.; DeBruyn, J.

    2015-12-01

    biological properties which are important indicators of sustainability.

  9. Using redescription mining to relate clinical and biological characteristics of cognitively impaired and Alzheimer's disease patients.

    Science.gov (United States)

    Mihelčić, Matej; Šimić, Goran; Babić Leko, Mirjana; Lavrač, Nada; Džeroski, Sašo; Šmuc, Tomislav

    2017-01-01

    Based on a set of subjects and a collection of attributes obtained from the Alzheimer's Disease Neuroimaging Initiative database, we used redescription mining to find interpretable rules revealing associations between those determinants that provide insights about the Alzheimer's disease (AD). We extended the CLUS-RM redescription mining algorithm to a constraint-based redescription mining (CBRM) setting, which enables several modes of targeted exploration of specific, user-constrained associations. Redescription mining enabled finding specific constructs of clinical and biological attributes that describe many groups of subjects of different size, homogeneity and levels of cognitive impairment. We confirmed some previously known findings. However, in some instances, as with the attributes: testosterone, ciliary neurotrophic factor, brain natriuretic peptide, Fas ligand, the imaging attribute Spatial Pattern of Abnormalities for Recognition of Early AD, as well as the levels of leptin and angiopoietin-2 in plasma, we corroborated previously debatable findings or provided additional information about these variables and their association with AD pathogenesis. Moreover, applying redescription mining on ADNI data resulted with the discovery of one largely unknown attribute: the Pregnancy-Associated Protein-A (PAPP-A), which we found highly associated with cognitive impairment in AD. Statistically significant correlations (p ≤ 0.01) were found between PAPP-A and clinical tests: Alzheimer's Disease Assessment Scale, Clinical Dementia Rating Sum of Boxes, Mini Mental State Examination, etc. The high importance of this finding lies in the fact that PAPP-A is a metalloproteinase, known to cleave insulin-like growth factor binding proteins. Since it also shares similar substrates with A Disintegrin and the Metalloproteinase family of enzymes that act as α-secretase to physiologically cleave amyloid precursor protein (APP) in the non-amyloidogenic pathway, it could be

  10. Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics.

    Science.gov (United States)

    Ding, Chenyue; Li, Hong; Wang, Yun; Wang, Fuxin; Wu, Huihua; Chen, Rulei; Lv, Jinghuan; Wang, Wei; Huang, Boxian

    2017-07-27

    Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function damaged by chemotherapy in a mice model. Understanding of how to evaluate the distinct effects of adult stem cells in curing POA and how to choose stem cells in clinical application is lacking. To build a different degrees of POA model, mice were administered different doses of cyclophosphamide: light dose (70 mg/kg, 2 weeks), medium dose (70 mg/kg, 1 week; 120 mg/kg, 1 week), and high dose (120 mg/kg, 2 weeks). Enzyme-linked immunosorbent assay detected serum levels of sex hormones, and hematoxylin and eosin staining allowed follicle counting and showed the ovarian tissue structure. DiIC 18 (5)-DS was employed to label human amniotic mesenchymal stem cells (hAMSCs) and hAECs for detecting the cellular retention time in ovaries by a live imaging system. Proliferation of human ovarian granule cells (ki67, AMH, FSHR, FOXL2, and CYP19A1) and immunological rejection of human peripheral blood mononuclear cells (CD4, CD11b, CD19, and CD56) were measured by flow cytometry (fluorescence-activated cell sorting (FACS)). Distinction of cellular biological characteristics between hAECs and hAMSCs was evaluated, such as collagen secretory level (collagen I, II, III, IV, and VI), telomerase activity, pluripotent markers tested by western blot, expression level of immune molecules (HLA-ABC and HLA-DR) analyzed by FACS, and cytokines (growth factors, chemotactic factors, apoptosis factors, and inflammatory factors) measured by a protein antibody array methodology. After hAMSCs and hAECs were transplanted into a different degrees of POA model, hAMSCs exerted better therapeutic activity on mouse ovarian function in the high-dose administration group, promoting the proliferation rate of ovarian granular cells from premature ovarian failure patients, but also provoking immune

  11. BIOLOGICAL CHARACTERISTICS OF FUSARIUM GRAMINEARUM SCHW. AND FUSARIUM CULMORUM (W.G. SMITH SACC.

    Directory of Open Access Journals (Sweden)

    Jasenka Ćosić

    2006-12-01

    Full Text Available Fusarium species from section Discolor are widespread and well-known and play an important role in disease etiology of wheat, barley and maize. F. graminearum and F. culmorum were isolated during a four-year period at several locations in Eastern Croatia and from different hosts. The mycelium development of 236isolates of F. graminearum and 2 isolates of F. culmorum was cultered during an eight day period on water agar, PDA, Bilai, Czapek's and CLA agar at temperatures 5°, 15°, 20°, 25° and 30°C and a 12 hour dark/light regime. The results show that agar medium does not influence colony diameter significantly. The agar medium influences the richness and density of the aerial mycelium significantly, although the shape and compactness of the mycelium is not only the result of the medium on which the fungus is developed, but also of the characteristics of the species itself. The sporulation of F. culmorum was abundant on all investigated medium, whereas the sporulation of F. graminearum was very weak on PDA and Bilai agar and it was medium on CLA.

  12. The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review.

    Science.gov (United States)

    Asadi-Samani, Majid; Bahmani, Mahmoud; Rafieian-Kopaei, Mahmoud

    2014-09-01

    Borage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  13. Coriandrum sativum mediated synthesis of silver nanoparticles and evaluation of their biological characteristics

    Science.gov (United States)

    Senthilkumar, N.; Aravindhan, V.; Ruckmani, K.; Vetha Potheher, I.

    2018-05-01

    Silver (Ag) nanoparticles (NPs) were prepared by percolated green synthesis method using Coriandrum sativum leaf, root, seed and stem extracts and reported its antibacterial activity. The synthesized Ag NPs were confirmed by UV–visible Spectroscopy, Powder x-ray Diffraction (PXRD), Fourier Transform Infra Red (FT-IR) Spectroscopy analyzes. The Maximum absorbance observed around 400–450 nm reveal the characteristic absorbance of Ag NPs. The Dynamic Light Scattering (DLS) analysis shows the stability of synthesized NPs with average size varying from 35 to 53 nm and also zeta potential stability varying from ‑20 to ‑30 mV. The cubic structure, crystalline nature and purity of the material was confirmed by powder x-ray diffraction studies. FT-IR spectrum shows the presence of various functional groups in the resultant material. The Field Emission Scanning Electron Microscopy (FESEM) image shows the surface morphology of the synthesized NPs and the Energy Dispersive x-ray Analysis (EDAX) confirms the presence of silver metal ions. The Coriandrum sativum aqueous extract exhibited excellent antimicrobial activity against Klebsiella pneumoniae (Gram -ve) bacteria. Numerous studies have been made previously in our field of study but optimization has not been carried out by both extract (different parts like leaf, root, seed and stem) and without addition of any external source such as chemicals, heat etc.

  14. Identification and characteristics of biological agents in work environment of medical emergency services in selected ambulances

    Directory of Open Access Journals (Sweden)

    Agata Bielawska-Drózd

    2017-08-01

    Full Text Available Objectives: Assessment of microbial air quality and surface contamination in ambulances and administration offices as a control place without occupational exposure to biological agents; based on quantitative and qualitative analysis of bacteria, yeasts and filamentous fungi found in collected samples. Material and Methods: The sampling was done by wet cyclone technology using the Coriolis recon apparatus, imprint and swab methods, respectively. In total, 280 samples from 28 ambulances and 10 offices in Warszawa were tested. Data was analyzed using Shapiro-Wilk normality test, Kruskal-Wallis test with α = 0.05. P value ≤ 0.05 was considered as significant. Results: The levels of air contamination were from 0 to 2.3×101 colony-forming unit (CFU/m3 for bacteria and for yeast and filamentous fungi were from 0 to 1.8×101 CFU/m3. The assessment of office space air samples has shown the following numbers of microorganisms: bacteria from 3.0×101 to 4.2×101 CFU/m3 and yeast and filamentous fungi from 0 to 1.9×101 CFU/m3. For surface contamination the mean bacterial count in ambulances has been between 1.0×101 and 1.3×102 CFU/25 cm2 and in offices – between 1.1×101 and 8.5×101 CFU/25 cm2. Mean fungal count has reached the level from 2.8×100 to 4.2×101 CFU/25 cm2 in ambulances and 1.3×101 to 5.8×101 CFU/25 cm2 in offices. The qualitative analysis has revealed the presence of Acinetobacter spp. (surfaces, coagulase – negative Staphylococci (air and surfaces, Aspergillus and Penicillium genera (air and surfaces. Conclusions: The study has revealed a satisfactory microbiological quantity of analyzed air and surface samples in both study and control environments. However, the presence of potentially pathogenic microorganisms in the air and on surfaces in ambulances may endanger the medical emergency staff and patients with infection. Disinfection and cleaning techniques therefore should be constantly developed and implemented. Int J Occup

  15. Identification and characteristics of biological agents in work environment of medical emergency services in selected ambulances.

    Science.gov (United States)

    Bielawska-Drózd, Agata; Cieślik, Piotr; Wlizło-Skowronek, Bożena; Winnicka, Izabela; Kubiak, Leszek; Jaroszuk-Ściseł, Jolanta; Depczyńska, Daria; Bohacz, Justyna; Korniłłowicz-Kowalska, Teresa; Skopińska-Różewska, Ewa; Kocik, Janusz

    2017-06-19

    Assessment of microbial air quality and surface contamination in ambulances and administration offices as a control place without occupational exposure to biological agents; based on quantitative and qualitative analysis of bacteria, yeasts and filamentous fungi found in collected samples. The sampling was done by wet cyclone technology using the Coriolis recon apparatus, imprint and swab methods, respectively. In total, 280 samples from 28 ambulances and 10 offices in Warszawa were tested. Data was analyzed using Shapiro-Wilk normality test, Kruskal-Wallis test with α = 0.05. P value ≤ 0.05 was considered as significant. The levels of air contamination were from 0 to 2.3×101 colony-forming unit (CFU)/m3 for bacteria and for yeast and filamentous fungi were from 0 to 1.8×101 CFU/m3. The assessment of office space air samples has shown the following numbers of microorganisms: bacteria from 3.0×101 to 4.2×101 CFU/m3 and yeast and filamentous fungi from 0 to 1.9×101 CFU/m3. For surface contamination the mean bacterial count in ambulances has been between 1.0×101 and 1.3×102 CFU/25 cm2 and in offices - between 1.1×101 and 8.5×101 CFU/25 cm2. Mean fungal count has reached the level from 2.8×100 to 4.2×101 CFU/25 cm2 in ambulances and 1.3×101 to 5.8×101 CFU/25 cm2 in offices. The qualitative analysis has revealed the presence of Acinetobacter spp. (surfaces), coagulase - negative Staphylococci (air and surfaces), Aspergillus and Penicillium genera (air and surfaces). The study has revealed a satisfactory microbiological quantity of analyzed air and surface samples in both study and control environments. However, the presence of potentially pathogenic microorganisms in the air and on surfaces in ambulances may endanger the medical emergency staff and patients with infection. Disinfection and cleaning techniques therefore should be constantly developed and implemented. Int J Occup Med Environ Health 2017;30(4):617-627. This work is available in Open Access

  16. Biological CO2 fixation using Chlorella vulgaris and its thermal characteristics through thermogravimetric analysis.

    Science.gov (United States)

    Razzak, Shaikh A; Ali, Saad Aldin M; Hossain, Mohammad M; Mouanda, Alexis Nzila

    2016-11-01

    The present research is focused on cultivation of microalgae strain Chlorella vulgaris for bio-fixation of CO2 coupled with biomass production. In this regard, a single semi-batch vertical tubular photobioreactor and four similar photobioreactors in series have been employed. The concentration of CO2 in the feed stream was varied from 2 to 12 % (v/v) by adjusting CO2 to air ratio. The amount of CO2 capture and algae growth were monitored by measuring decrease of CO2 concentration in the gas phase, microalgal cell density, and algal biomass production rate. The results show that 4 % CO2 gives maximum amount of biomass (0.9 g L(-1)) and productivity (0.118 g L(-1) day(-1)) of C. vulgaris in a single reactor. In series reactors, average productivity per reactor found to be 0.078 g L(-1) day(-1). The maximum CO2 uptake for single reactor also found with 4 % CO2, and it is around 0.2 g L(-1) day(-1). In series reactors, average CO2 uptake is 0.13 g L(-1) day(-1) per reactor. TOC analysis shows that the carbon content of the produced biomass is around 40.67 % of total weight. The thermochemical characteristics of the cultivated C. vulgaris samples were analyzed in the presence of air. All samples burn above 200 °C and the combustion rate become faster at around 600 °C. Almost 98 wt% of the produced biomass is combustible in this range.

  17. Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts.

    Directory of Open Access Journals (Sweden)

    Binafsha M Syed

    Full Text Available Triple negative (ER, PgR and HER2 negative breast cancers (TNBCs are often considered as a poor prognostic phenotype. There is dearth of evidence showing the prevalence and biological behaviour of TNBCs in older women. This study aimed to analyse their biological characteristics in comparison with a well characterised younger series from a single centre with long term clinical follow-up. Over 37 years (1973-2010, 1,758 older (≥70 years women with early operable (<5 cm primary breast cancer were managed in a dedicated clinic and have complete clinical information available. Of these 813 patients underwent primary surgery and 575 had good quality tumour samples available for tissue microarray analysis using indirect immunohistochemistry. A total of 127 patients (22.1% had TNBCs and full biological analysis of 15 biomarkers was performed. The results were compared with those of their younger (<70 years counterparts 342 (18.9% from a previously characterised, consecutive series of primary breast cancer treated in the same unit (1986-1998. The 127 older patients with TNBCs showed lower rates of Ki67 and CK 7/8 positivity and high rates of bcl2 and CK18 positivity when compared with their younger counterparts (p<0.05. There was no significant difference in the long term clinical outcome between the two age groups, despite the fact that 47% of the younger patients had adjuvant chemotherapy, while none in the older cohort received such treatment. EGFR, axillary stage and pathological size showed prognostic significance in older women with TNBCs on univariate analysis. Despite not having received adjuvant chemotherapy, the older series had clinical outcome similar to the younger patients almost half of whom had chemotherapy. This appears to be related to other biomarkers (in addition to ER/PgR/HER2 eg Ki67, bcl2 and cytokeratins which have different expression patterns influencing prognosis.

  18. Biological characteristics of Trichospilus diatraeae (Hymenopetra: Eulophidae in the hosts Bombyx mori (Lepidoptera: Bombycidae and Diatraea saccharalis (Lepidoptera: Crambidae

    Directory of Open Access Journals (Sweden)

    Vanessa Rodrigues Ferreira Calado

    2014-03-01

    Full Text Available Trichospilus diatraeae Cherian & Margabandhu, 1942 (Hymenoptera: Eulophidae is a pupal endoparasitoid of lepidoptera and it has been studied as a potential agent for biological control of pests. For developing techniques to breed parasitoids, there is a need to choose the appropriate alternative host, thus, this article aims to evaluate the biological characteristics of T. diatraeae with regard to the hosts Bombyx mori Linneaus (Lepidoptera: Bombycidae and Diatraea saccharalis (Fabricius (Lepidoptera: Crambidae, in laboratory. Twelve pupae of B. mori and twelve pupae of D. saccharalis, within 72 and 24 h of life, respectively, were exposed to parasitism by 21 female parasitoids at 25 ± 1°C, with relative humidity 70 ± 10% and photophase of 14 h. Life-cycle duration (egg – adult of T. diatraeae was 19.44 ± 0.12 days in pupae of D. saccharalis and 18.00 ± 0.05 days in pupae of B. mori, the emergence of parasitoid progeny was 66.60% in pupae of D. saccharalis, and 75.00% in pupae of B. mori. The progeny of T. diatraeae was 354.50 ± 43.21 per pupa of D. saccharalis and 469.11 ± 15.19 per pupa of B. mori. Trichospilus diatraeae showed suitability to the host and its ability to parasitize various hosts.

  19. Age-dependent change in biological characteristics of stem cells in radiation-induced mammary carcinogenesis

    International Nuclear Information System (INIS)

    Shimada, Yoshiya; Nishimura, Mayumi; Kakinuma, Shizuko; Imaoka, Tatsuhiko; Yasukawa-Barnes, Jane; Gould, Michael N.; Clifton, Kelly H.

    2003-01-01

    If you ask what types of cells are the targets for carcinogenesis, a popular answer would be that cancer arises from stem cells. Stem cells are cells that are capable of both self-renewal and generation of differentiated progenies. If the hypothesis of 'cancer as stem cell disease' is correct, the risk of carcinogenesis should be a function of the number of stem cells and their responsiveness of carcinogen-induced damage. In the present study, we addressed the feasibility of this hypothesis using the rat mammary carcinogenesis model. One of the important conclusions emerging from studies on atomic bomb survivors concerns age-related changes in the susceptibility to breast cancer. The relative risk of breast cancer is very high among women exposed to ionizing radiation before or during puberty, and it decreases thereafter. Little information is available, however, on age-related changes in the radiobiological nature of mammary stem cells. We examined age-associated changes in the number of mammary stem-like cells (clonogens) and their susceptibility to radiation in terms of cell death and carcinogenic initiation frequency. The results were as follows. (1) During the prepubertal period, the total number of mammary clonogens per rat increased exponentially with a population doubling time of ∼4 days. After puberty, the doubling time lengthened to ∼30 days. The total number of clonogens in abdominal and inguinal mammary glands was ∼200 in 2-week-old rats, while it was ∼5600 in 8-week-old rats. (2) The survival curves of clonogenic cells after irradiation indicated that radiation sensitivity of the cells before and during puberty was much higher than after puberty. (3) The initiation frequency of the clonogens from prepubertal rats after 5 Gy irradiation was four times higher than that of the clonogens from post-pubertal rats. These results suggest that changes in the number of stem cells and their radiobiological characteristics underlie the age

  20. Age-dependent change in biological characteristics of stem cells in radiation-induced mammary carcinogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Yoshiya; Nishimura, Mayumi; Kakinuma, Shizuko; Imaoka, Tatsuhiko [National Institute of Radiological Sciences, Anagawa, Chiba (Japan); Yasukawa-Barnes, Jane; Gould, Michael N.; Clifton, Kelly H. [Univ. of Wisconsin, Department of Human Oncology, Madison, WI (United States)

    2003-07-01

    If you ask what types of cells are the targets for carcinogenesis, a popular answer would be that cancer arises from stem cells. Stem cells are cells that are capable of both self-renewal and generation of differentiated progenies. If the hypothesis of 'cancer as stem cell disease' is correct, the risk of carcinogenesis should be a function of the number of stem cells and their responsiveness of carcinogen-induced damage. In the present study, we addressed the feasibility of this hypothesis using the rat mammary carcinogenesis model. One of the important conclusions emerging from studies on atomic bomb survivors concerns age-related changes in the susceptibility to breast cancer. The relative risk of breast cancer is very high among women exposed to ionizing radiation before or during puberty, and it decreases thereafter. Little information is available, however, on age-related changes in the radiobiological nature of mammary stem cells. We examined age-associated changes in the number of mammary stem-like cells (clonogens) and their susceptibility to radiation in terms of cell death and carcinogenic initiation frequency. The results were as follows. (1) During the prepubertal period, the total number of mammary clonogens per rat increased exponentially with a population doubling time of {approx}4 days. After puberty, the doubling time lengthened to {approx}30 days. The total number of clonogens in abdominal and inguinal mammary glands was {approx}200 in 2-week-old rats, while it was {approx}5600 in 8-week-old rats. (2) The survival curves of clonogenic cells after irradiation indicated that radiation sensitivity of the cells before and during puberty was much higher than after puberty. (3) The initiation frequency of the clonogens from prepubertal rats after 5 Gy irradiation was four times higher than that of the clonogens from post-pubertal rats. These results suggest that changes in the number of stem cells and their radiobiological characteristics

  1. Predictability of Stock Returns

    Directory of Open Access Journals (Sweden)

    Ahmet Sekreter

    2017-06-01

    Full Text Available Predictability of stock returns has been shown by empirical studies over time. This article collects the most important theories on forecasting stock returns and investigates the factors that affecting behavior of the stocks’ prices and the market as a whole. Estimation of the factors and the way of estimation are the key issues of predictability of stock returns.

  2. Influence of the nucleobase on the physicochemical characteristics and biological activities of Sb{sup V}-ribonucleoside complexes

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Claudio S.; Demicheli, Cynthia, E-mail: demichel@netuno.lcc.ufmg.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Quimica; Rocha, Iara C.M. da; Melo, Maria N. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Parasitologia; Monte Neto, Rubens L.; Frezard, Frederic [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisiologia e Biofisica

    2010-07-01

    The influence of the nucleobase (uracyl, U; cytosine, C; adenine, A; guanine, G) on the physicochemical characteristics and in vitro biological activities of Sb{sup V}-ribonucleoside complexes has been investigated. The 1:1 Sb-U and Sb-C complexes were characterized by NMR and ESI-MS spectroscopies and elemental analysis. The stability constant and the apparent association and dissociation rate constants of 1:1 Sb{sup V}-U, Sb{sup V}-C and Sb{sup V}-A complexes were determined. Although Sb{sup V} most probably binds via oxygen atoms to the same 2' and 3' positions in the different nucleosides, the ribose conformational changes and the physicochemical characteristics of the complex depend on the nucleobase. The nucleobase had a strong influence on the cytotoxicity against macrophages and the antileishmanial activity of the Sb{sup V}-ribonucleoside complexes. The Sb{sup V}-purine complexes were more cytotoxic and more effective against Leishmania chagasi than the Sb{sup V}-pyrimidine complexes, supporting the model that the interaction of Sb{sup V} with purine nucleosides may mediate the antileishmanial activity of pentavalent antimonial drugs. (author)

  3. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study

    Directory of Open Access Journals (Sweden)

    P. Pronzato

    2011-01-01

    Full Text Available Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (>3500 were enrolled at 77 Italian hospitals. Women aged ≤50 years (=1013 were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years. The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(2=7.07; =.008, HER2 amplification (2=5.76; =.01, and high (≥10% Ki67 labelling index (2=9.53; =.002. Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (40 versus ≤40, <.0001, resp.. At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, =.0021. Conclusion. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial.

  4. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women-A Featured Population: Results from the Nora Study

    International Nuclear Information System (INIS)

    Pronzato, P.; Mustacchi, G.; De Matteis, A.; Di Costanzo, F.; Rulli, E.; Floriani, I; Cazzaniga, M.E.

    2011-01-01

    Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000-2002, patients (N>3500) were enrolled at 77 Italian hospitals. Women aged =50 years (N=1013) were stratified into age groups (=35, 36-40, 41-45, and 46-50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(x 2 =7.07; P=.008), HER2 amplification (x 2 =5.76; P=.01), and high (≤10%) Ki67 labelling index (x 2 =9.53; P=.002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (P 40 versus =40, P<.0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, P=.0021). Conclusion. This cohort study suggests that age per se is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial. human epidermal growth factor receptor

  5. pH sensitivity of Swedish forest streams related to catchment characteristics and geographical location - Implications for forest bioenergy harvest and ash return

    Science.gov (United States)

    Ågren, Anneli; Löfgren, Stefan

    2013-04-01

    Whole-tree harvesting acidifies forest soils more than conventional harvest of stems. There is concern that this excess acidification will also affect surface waters and counteract the well-documented recovery from acid deposition in streams and lakes. Here we present a first attempt to identify the landscape types within Sweden where the streams are most sensitive to acidification and potentially in need of protection from excessive biomass harvest or countermeasures such as ash application. Conservative estimates indicate that forest slash must be harvested from >30 ha to produce the amount of ash needed to restore 1 ha acidified surface water. This highlights the need for careful planning of where ash should be distributed. Streams with a high pH are well buffered by the bicarbonate system and not sensitive to a potential pH decline. Streams with a low pH are also well buffered by dissolved organic carbon and aluminum and are not likely affected by bioenergy harvest. However, streams in the intermediate pH range (5-6.2) are potentially sensitive to acidification from excess base cation removal due to whole-tree harvesting. In such streams a small change in acid neutralizing capacity (ANC) can change pH dramatically. The pH sensitivity of 218 streams in different regions (northern, central, southern, and southwest Sweden) was defined from stream water pH and related to catchment characteristics and stream water acid-base chemistry. At the national level, catchments with till soils and a large proportion of forested wetlands formed the most pH sensitive areas. Because of regional variability in acidification history, amount and distribution of quaternary deposits, vegetation cover, etc. pH sensitivity was determined by different landscape elements in different regions. For example, in northern Sweden streams draining forest mires were the most pH sensitive streams. The patchy spatial distribution of this landscape type, makes it difficult from an administrative

  6. Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX® Colon Cancer Assay

    International Nuclear Information System (INIS)

    Clark-Langone, Kim M; Sangli, Chithra; Krishnakumar, Jayadevi; Watson, Drew

    2010-01-01

    The Oncotype DX ® Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary colon tumor tissue. Like the Oncotype DX Breast Cancer Assay, this is a high complexity, multi-analyte, reverse transcription (RT) polymerase chain reaction (PCR) assay that measures the expression levels of specific cancer-related genes. By capturing the biology underlying each patient's tumor, the Oncotype DX Colon Cancer Assay provides a Recurrence Score (RS) that reflects an individualized risk of disease recurrence. Here we describe its analytical performance using pre-determined performance criteria, which is a critical component of molecular diagnostic test validation. All analytical measurements met pre-specified performance criteria. PCR amplification efficiency for all 12 assays was high, ranging from 96% to 107%, while linearity was demonstrated over an 11 log 2 concentration range for all assays. Based on estimated components of variance for FPE RNA pools, analytical reproducibility and precision demonstrated low SDs for individual genes (0.16 to 0.32 C T s), gene groups (≤0.05 normalized/aggregate C T s) and RS (≤1.38 RS units). Analytical performance characteristics shown here for both individual genes and gene groups in the Oncotype DX Colon Cancer Assay demonstrate consistent translation of specific biology of individual tumors into clinically useful diagnostic information. The results of these studies illustrate how the analytical capability of the Oncotype DX Colon Cancer Assay has enabled clinical validation of a test to determine individualized recurrence risk after colon cancer surgery

  7. Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX® Colon Cancer Assay

    Directory of Open Access Journals (Sweden)

    Krishnakumar Jayadevi

    2010-12-01

    Full Text Available Abstract Background The Oncotype DX® Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE primary colon tumor tissue. Like the Oncotype DX Breast Cancer Assay, this is a high complexity, multi-analyte, reverse transcription (RT polymerase chain reaction (PCR assay that measures the expression levels of specific cancer-related genes. By capturing the biology underlying each patient's tumor, the Oncotype DX Colon Cancer Assay provides a Recurrence Score (RS that reflects an individualized risk of disease recurrence. Here we describe its analytical performance using pre-determined performance criteria, which is a critical component of molecular diagnostic test validation. Results All analytical measurements met pre-specified performance criteria. PCR amplification efficiency for all 12 assays was high, ranging from 96% to 107%, while linearity was demonstrated over an 11 log2 concentration range for all assays. Based on estimated components of variance for FPE RNA pools, analytical reproducibility and precision demonstrated low SDs for individual genes (0.16 to 0.32 CTs, gene groups (≤0.05 normalized/aggregate CTs and RS (≤1.38 RS units. Conclusions Analytical performance characteristics shown here for both individual genes and gene groups in the Oncotype DX Colon Cancer Assay demonstrate consistent translation of specific biology of individual tumors into clinically useful diagnostic information. The results of these studies illustrate how the analytical capability of the Oncotype DX Colon Cancer Assay has enabled clinical validation of a test to determine individualized recurrence risk after colon cancer surgery.

  8. Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer Assay.

    Science.gov (United States)

    Clark-Langone, Kim M; Sangli, Chithra; Krishnakumar, Jayadevi; Watson, Drew

    2010-12-23

    The Oncotype DX Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary colon tumor tissue. Like the Oncotype DX Breast Cancer Assay, this is a high complexity, multi-analyte, reverse transcription (RT) polymerase chain reaction (PCR) assay that measures the expression levels of specific cancer-related genes. By capturing the biology underlying each patient's tumor, the Oncotype DX Colon Cancer Assay provides a Recurrence Score (RS) that reflects an individualized risk of disease recurrence. Here we describe its analytical performance using pre-determined performance criteria, which is a critical component of molecular diagnostic test validation. All analytical measurements met pre-specified performance criteria. PCR amplification efficiency for all 12 assays was high, ranging from 96% to 107%, while linearity was demonstrated over an 11 log2 concentration range for all assays. Based on estimated components of variance for FPE RNA pools, analytical reproducibility and precision demonstrated low SDs for individual genes (0.16 to 0.32 CTs), gene groups (≤ 0.05 normalized/aggregate CTs) and RS (≤ 1.38 RS units). Analytical performance characteristics shown here for both individual genes and gene groups in the Oncotype DX Colon Cancer Assay demonstrate consistent translation of specific biology of individual tumors into clinically useful diagnostic information. The results of these studies illustrate how the analytical capability of the Oncotype DX Colon Cancer Assay has enabled clinical validation of a test to determine individualized recurrence risk after colon cancer surgery.

  9. Predictable return distributions

    DEFF Research Database (Denmark)

    Pedersen, Thomas Quistgaard

    trace out the entire distribution. A univariate quantile regression model is used to examine stock and bond return distributions individually, while a multivariate model is used to capture their joint distribution. An empirical analysis on US data shows that certain parts of the return distributions......-of-sample analyses show that the relative accuracy of the state variables in predicting future returns varies across the distribution. A portfolio study shows that an investor with power utility can obtain economic gains by applying the empirical return distribution in portfolio decisions instead of imposing...

  10. 驯鹿及其生物学特性研究%Reindeer and Its Biological Characteristics

    Institute of Scientific and Technical Information of China (English)

    常悦; 张玉; 陈巴特尔; 孙亚红

    2013-01-01

    驯鹿分布于北极圈及其周边地区,耐寒怕燥,处于野生或半驯化状态.本文通过对驯鹿的生态分布,形态特征(包括个体大小、被毛、茸角、鼻、蹄、视力),进食习性,繁殖习性,迁徙活动以及天敌等几方面对驯鹿的生物学特性做出较为全面的介绍,以便为今后的驯鹿保护工作奠定基础,从而制定出针对性更强的保护措施.%The reindeer inhabits in the Arctic Circle and its surrounding areas, which is cold resistant and afraid of dryness and in the wild or semi-domesticated state. The paper comprehensively introduced the biological characteristics of the reindeer through such aspects as its ecological distribution, morphological character (including body size, fur, antler, nose, feet and eyesight), eating habit, breeding habit, migrating activities as well as its natural enemies, so as to lay a foundation for the protection work and therefore developing more effective protective measures.

  11. Comparative Study of Biological Characteristics of Larvae, Crude and Dried Cocoon in 7 Races of Silkworm Bombyx mori L., Raised in Transylvania Area

    Directory of Open Access Journals (Sweden)

    Emilia Maria Furdui

    2010-05-01

    Full Text Available 7 monovoltine races of Romanian silkworm Bombyx mori L. were breeded in specific Transylvania conditions, assuring the same microclimate conditions, being fed with the same mulberry leaves (Ukraina 107. The results obtained showed a high homogeneity, the differences were due to the variability and genotype characteristic for each individual of every race. Results and standard deviations are within the race standard. The study permitted a ierarchy of the races, following the biological characteristics, microclimate conditions, quantity, quality and breeding technology.

  12. Classifying Returns as Extreme

    DEFF Research Database (Denmark)

    Christiansen, Charlotte

    2014-01-01

    I consider extreme returns for the stock and bond markets of 14 EU countries using two classification schemes: One, the univariate classification scheme from the previous literature that classifies extreme returns for each market separately, and two, a novel multivariate classification scheme tha...

  13. Correlates of Parents' Involvement with Their Adolescent Children in Restructured and Biological Two-Parent Families: The Role of Child Characteristics

    Science.gov (United States)

    Flouri, Eirini

    2004-01-01

    This study used data from both 225 fathers and mothers as well as their secondary school age children to explore the role of child characteristics (sex, age, self-esteem, and emotional and behavioural well-being) in mother's and father's involvement in biological and restructured (stepfather) two-parent families after controlling for known…

  14. Improvement of chemical and biological characteristics of gossan mine wastes following application of amendments and growth of Cistus ladanifer L.

    Science.gov (United States)

    Santos, Erika; Abreu, Maria Manuela; Macías, Felipe; de Varennes, Amarilis

    2013-04-01

    Cistus ladanifer is considered a good option for phytostabilization of mine wastes, composed of several materials, but its growth is very slow due to substrata conditions (acidic pH, low fertility and water availability, high total concentrations of hazardous elements). To enhance the growth of C. ladanifer with application of organic/inorganic amendments can be a strategy to speed up remediation. This study aimed to evaluate the influence of different rates of amendments and C. ladanifer growth on the improvement of chemical and biological characteristics of gossan wastes. Composite samples of mining wastes (gossan+host rocks) were collected at the São Domingos mine. Amendments used were mixtures (30, 75, 150 Mg/ha) of rockwool, agriculture wastes and wastes from liquor distillation obtained from fruits of Arbutus unedo. Four treatments (n=6 replicates) were carried out (control and three amended treatments) under controlled conditions in a greenhouse. After one month of incubation at 70% of water holding capacity, C. ladanifer was sown in half of the pots from each treatment (n=3), and the other three pots remained in the same conditions without plant. Chemical and biological characteristics of the wastes (with/without plants) were analysed after incubation and fifteen months. Gossan wastes had great total concentrations of several elements (g/kg; Al: 24.8, As: 3.03, Cu: 0.23, Pb; 9.21) whereas in an extracting solution (diluted solution of organic acids) these were small (0.5 units), fertility (Corganic, Pextractable, Ntotal) and dehydrogenase activity of mine wastes, principally with the rate of 150 Mg/ha, even after one month of incubation and after the plants be sown. In both sampling periods (beginning/end of the experiment), Kextractable concentrations increased only with the high application rates (control and 30 Mg/ha treatment: 1.02-1.88 mg/kg; other amended treatments: 2.13-3.55 mg/kg). At the end of the experiment, the presence of the plant increased

  15. BIOLOGICAL CHARACTERISTICS OF PRUSSIAN CARP (CARASSIUS AURATUS GIBELIO (BLOCH, 1782 COMMERCIAL STOCK OF THE DNIEPER-BUG ESTUARY

    Directory of Open Access Journals (Sweden)

    К. Heina

    2017-09-01

    gradual decline Fulton condition factor from 3.47±0.22 in age-3 fish to 3.12±0.06 in age-6 fish. The highest variability of these indexes was typical for age-5 fish (Cv=10.9%; lim=2.46-3.89, that was related to the linear-weight growth and fecundity. With an increase in the age, the variableness of condition factor reduced substantially. Originality. The paper contains modern and significantly updated data on main biological characteristics of the Prussian carp commercial stock in the transformed conditions of the Dnieper-Bug estuary. Practical value. The obtained results are a scientific background for rational fishery optimization of commercial pressure on the representatives of valuable fish fauna of the Dnieper-Bug estuary. In current conditions, the presented information is actual enough from the point of view of the maintenance and support the biodiversity of valuable commercial species in natural water bodies of Ukraine.

  16. Commercial-biological characteristics of tulka (Clupeonella cultriventris Nordmann, 1840 of the Dnieper-Bug estuary system

    Directory of Open Access Journals (Sweden)

    K. Geina

    2017-12-01

    =17.42 and Cv=15.92%, respectively. The variability of body weight in fish of the right wing of the age series depended by a stable prevalence of females in the stock structure, which were characterized by more significant fluctuations of mean weight due to differences during sexual gland development. The condition factor of tulka was high, Fulton’s condition factor values varied from 0.85 to 1.04. At the same time, a gradual growth of the condition factor with an increase in age was observed. The highest variability of the condition factor was typical for age-2 and age-3 fish – Cv=12.8-15.2%. Originality. The paper contains new as well as updated already existing data on major biological characteristics of the commercial stock of tulka in transformed conditions of fish fauna existence in the Dnieper-Bug estuary system. Practical value. The obtained results are a scientific basis for rational fishery and optimization of fishing pressure on this clupeid species of the Dnieper-Bug estuary system. Under the current conditions, the provided information is topical from the point of view of the improvement of the trophological status of a valuable fishery water body in the context of the reduction of the level of trophic competition between juveniles of semi-migratory fish species and typical zooplantonivorous species such as tulka, which currently increased its abundance.

  17. The establishment of transmissible venereal tumor lung cancer model in canine and the observation of its biological characteristics

    International Nuclear Information System (INIS)

    Sun Zhichao; Dong Weihua; Xiao Xiangsheng; Zhu Ruimin; Chen mofan; Wang Zhi

    2010-01-01

    Objective: To establish an allogeneic transplanted lung cancer model in canine by percutaneously injecting canine transmissible venereal tumor (CTVT) cell suspension and to observe its biological characteristics. Methods: Under CT guidance fresh CTVT cell suspension was inoculated into the middle or posterior lobe of lungs through percutaneous puncturing needle in 12 beagle dogs. Cyclosporin was administrated orally to obtain immunosuppression. Tumor growth and metastasis were judged by chest CT scanning at regular intervals (every 1-2 weeks). The daily mental and physical condition of the dogs was observed. Autopsy and pathological examination were performed when the animals died naturally or at the tenth week after the procedure when the animals were sacrificed. Results: A total of 15 sites were inoculated in 12 dogs. The formation of tumor was observed in 2 dogs at the fifth week and in 9 dogs at the sixth week. Ten weeks after the inoculation the formation of tumor was detected in 10 inoculated points in 9 dogs, the inoculation success rate was 66.67%. The mean largest diameter of the tumor at 6, 8 and 10 weeks after the inoculation was (1.059 ± 0.113)cm, (1.827 ± 0.084)cm and (2.189 ± 0.153)cm, respectively. The largest diameter of the tumor nodule was 3.5 cm. Moderate to severe pleural effusion and mediastinal lymph nodes metastasis were found in all the dogs that showed the formation of the tumor. Conclusion: Percutaneous CTVT cell suspension injection can establish an allogeneic canine lung cancer model, which is helpful for the experimental studies related to lung cancer. (authors)

  18. Lidar 2009 - All Returns

    Data.gov (United States)

    Kansas Data Access and Support Center — LIDAR-derived binary (.las) files containing classified points of all returns. We have 3 classifications Unclassified, Ground, Low points. The average Ground Sample...

  19. Influence of physical and chemical characteristics of diesel fuels and exhaust emissions on biological effects of particle extracts: a multivariate statistical analysis of ten diesel fuels.

    Science.gov (United States)

    Sjögren, M; Li, H; Banner, C; Rafter, J; Westerholm, R; Rannug, U

    1996-01-01

    The emission of diesel exhaust particulates is associated with potentially severe biological effects, e.g., cancer. The aim of the present study was to apply multivariate statistical methods to identify factors that affect the biological potency of these exhausts. Ten diesel fuels were analyzed regarding physical and chemical characteristics. Particulate exhaust emissions were sampled after combustion of these fuels on two makes of heavy duty diesel engines. Particle extracts were chemically analyzed and tested for mutagenicity in the Ames test. Also, the potency of the extracts to competitively inhibit the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the Ah receptor was assessed. Relationships between fuel characteristics and biological effects of the extracts were studied, using partial least squares regression (PLS). The most influential chemical fuel parameters included the contents of sulfur, certain polycyclic aromatic compounds (PAC), and naphthenes. Density and flash point were positively correlated with genotoxic potency. Cetane number and upper distillation curve points were negatively correlated with both mutagenicity and Ah receptor affinity. Between 61% and 70% of the biological response data could be explained by the measured chemical and physical factors of the fuels. By PLS modeling of extract data versus the biological response data, 66% of the genotoxicity could be explained, by 41% of the chemical variation. The most important variables, associated with both mutagenicity and Ah receptor affinity, included 1-nitropyrene, particle bound nitrate, indeno[1,2,3-cd]pyrene, and emitted mass of particles. S9-requiring mutagenicity was highly correlated with certain PAC, whereas S9-independent mutagenicity was better correlated with nitrates and 1-nitropyrene. The emission of sulfates also showed a correlation both with the emission of particles and with the biological effects. The results indicate that fuels with biologically less hazardous

  20. Tick size and stock returns

    Science.gov (United States)

    Onnela, Jukka-Pekka; Töyli, Juuso; Kaski, Kimmo

    2009-02-01

    Tick size is an important aspect of the micro-structural level organization of financial markets. It is the smallest institutionally allowed price increment, has a direct bearing on the bid-ask spread, influences the strategy of trading order placement in electronic markets, affects the price formation mechanism, and appears to be related to the long-term memory of volatility clustering. In this paper we investigate the impact of tick size on stock returns. We start with a simple simulation to demonstrate how continuous returns become distorted after confining the price to a discrete grid governed by the tick size. We then move on to a novel experimental set-up that combines decimalization pilot programs and cross-listed stocks in New York and Toronto. This allows us to observe a set of stocks traded simultaneously under two different ticks while holding all security-specific characteristics fixed. We then study the normality of the return distributions and carry out fits to the chosen distribution models. Our empirical findings are somewhat mixed and in some cases appear to challenge the simulation results.

  1. A review of the known biological characteristics of the Great Meteor East site together with a sampling programme for a biological site assessment

    International Nuclear Information System (INIS)

    Roe, H.S.J.

    1985-01-01

    Existing biological information on GME is reviewed. In common with most other oceanic areas there is very little data available from depths below 2000m. There is virtually no direct benthic information and none at all on the midwater/benthic boundary layer. Existing data from a wider geographic area are relevant to GME but the applicability of such data varies according to the hydrography. A sampling programme is outlined which will allow a comprehensive quantitative and qualitative assessment of the midwater and benthic ecosystems. Particular attention will be paid to the interactions between benthic and midwater communities just above the sea floor. (author)

  2. Exiting and Returning to the Parental Home for Boomerang Kids.

    Science.gov (United States)

    Sandberg-Thoma, Sara E; Snyder, Anastasia R; Jang, Bohyun Joy

    2015-06-01

    Young adults commonly exit from and return to the parental home, yet few studies have examined the motivation behind these exits and returns using a life course framework. Using data from the National Longitudinal Survey of Youth 1997, the authors examined associations between mental health problems and economic characteristics and exits from (n = 8,162), and returns to (n = 6,530), the parental home during the transition to adulthood. The average age of the respondents was 24 years. The authors found evidence that mental health and economic characteristics were related to home leaving and returning. Emotional distress was associated with earlier exits from, and returns to, the parental home; alcohol problems were associated with earlier returns to the parental home. The findings regarding economic resources were unexpectedly mixed. Greater economic resources were linked to delayed exits from, and earlier returns to, the parental home. The implications of these findings for young adults are discussed.

  3. Predicting the biological condition of streams: Use of geospatial indicators of natural and anthropogenic characteristics of watersheds

    Science.gov (United States)

    Carlisle, D.M.; Falcone, J.; Meador, M.R.

    2009-01-01

    We developed and evaluated empirical models to predict biological condition of wadeable streams in a large portion of the eastern USA, with the ultimate goal of prediction for unsampled basins. Previous work had classified (i.e., altered vs. unaltered) the biological condition of 920 streams based on a biological assessment of macroinvertebrate assemblages. Predictor variables were limited to widely available geospatial data, which included land cover, topography, climate, soils, societal infrastructure, and potential hydrologic modification. We compared the accuracy of predictions of biological condition class based on models with continuous and binary responses. We also evaluated the relative importance of specific groups and individual predictor variables, as well as the relationships between the most important predictors and biological condition. Prediction accuracy and the relative importance of predictor variables were different for two subregions for which models were created. Predictive accuracy in the highlands region improved by including predictors that represented both natural and human activities. Riparian land cover and road-stream intersections were the most important predictors. In contrast, predictive accuracy in the lowlands region was best for models limited to predictors representing natural factors, including basin topography and soil properties. Partial dependence plots revealed complex and nonlinear relationships between specific predictors and the probability of biological alteration. We demonstrate a potential application of the model by predicting biological condition in 552 unsampled basins across an ecoregion in southeastern Wisconsin (USA). Estimates of the likelihood of biological condition of unsampled streams could be a valuable tool for screening large numbers of basins to focus targeted monitoring of potentially unaltered or altered stream segments. ?? Springer Science+Business Media B.V. 2008.

  4. The correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions

    OpenAIRE

    Li Ma; Rong Zhou; Yun-Zhu Li

    2017-01-01

    Objective: To study the correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions. Methods: A total of 90 patients with thyroid cancer who accepted surgical treatment in our hospital between March 2015 and September 2016 were selected as the observation group, and 50 patients who received surgery in our hospital during the same period and were with clear pathological diagnosis of thyroid...

  5. Study on human-factors-engineering properties of reactor maintenance workers with protection suits, (2). Basic research on various biological characteristics in reactor maintenance simulation tests

    Energy Technology Data Exchange (ETDEWEB)

    Yoshino, K; Ishii, K; Nakasa, H [Central Research Inst. of Electric Power Industry, Tokyo (Japan); Shigeta, S

    1980-11-01

    To ensure the safety of reactor maintenance workers and to reduce the radiation exposure through the enhancement of labor efficiency, it is needed to evaluate quantitatively work-stress levels of workers with radiation-protection suits. This paper presents the results of reactor-maintenance simulation tests in which the relationship between the work stress and biological characteristics is investigated for 5 pinds of model works done by testees without protection suits in an artificial climate chamber. Major results obtained are: (1) the selected model works are mostly evaluated to be relatively heavy through the measurement of RMR (Relative Metabolic Rate). (2) biological characteristics such as heart rate and respiratory volume under the model works have close relationship to RMR which is the cumulative quantity in relatively long time, and then they may become the real-time indicator for the work stress level. (3) such biological characteristics are greatly affected by the high-temperature work-environment which is often seen in workers with protection suits.

  6. Fluctuation behaviors of financial return volatility duration

    Science.gov (United States)

    Niu, Hongli; Wang, Jun; Lu, Yunfan

    2016-04-01

    It is of significantly crucial to understand the return volatility of financial markets because it helps to quantify the investment risk, optimize the portfolio, and provide a key input of option pricing models. The characteristics of isolated high volatility events above certain threshold in price fluctuations and the distributions of return intervals between these events arouse great interest in financial research. In the present work, we introduce a new concept of daily return volatility duration, which is defined as the shortest passage time when the future volatility intensity is above or below the current volatility intensity (without predefining a threshold). The statistical properties of the daily return volatility durations for seven representative stock indices from the world financial markets are investigated. Some useful and interesting empirical results of these volatility duration series about the probability distributions, memory effects and multifractal properties are obtained. These results also show that the proposed stock volatility series analysis is a meaningful and beneficial trial.

  7. Policy implications of select student characteristics and their influence on the Florida biology end-of-course assessment

    Science.gov (United States)

    Bertolotti, Janine Cecelia

    In an attempt to improve student achievement in science in Florida, the Florida Department of Education implemented end-of-course (EOC) assessments in biology during the 2011-2012 academic school year. Although this first administration would only account for 30% of the student's overall final course grade in biology, subsequent administrations would be accompanied by increasing stakes for students, teachers, and schools. Therefore, this study sought to address gaps in empirical evidence as well as discuss how educational policy will potentially impact on teacher evaluation and professional development, student retention and graduation rates, and school accountability indicators. This study explored four variables- reading proficiency, ethnicity, socioeconomic status, and gender- to determine their influence and relationship on biology achievement on the Biology I EOC assessment at a Title 1 school. To do so, the results of the Biology I EOC assessment administered during the Spring 2012 school year was obtained from a small, rural Title 1 high school in North Florida. Additional data regarding each student's qualification for free and reduced-price lunch, FCAT Reading developmental scale scores, FCAT Reading level, grade level, gender, and ethnicity were also collected for the causal-comparative exploratory study. Of the 178 students represented, 48% qualified for free and reduced-price lunch, 54% were female, and 55% scored at FCAT Reading level 3 or higher. Additionally, 59% were White and 37% Black. A combination of descriptive statistics and other statistical procedures such as independent samples one-tailed t-test, one-way ANOVAs, ANCOVAs, multipleregression, and a Pearson r correlation was utilized in the analysis, with a significance level set at 0.05. Results indicate that of all four variables, FCAT Reading proficiency was the sole variable, after adjusting for other variables; that had a significant impact on biology achievement. Students with higher

  8. The Reference Return Ratio

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Faber Frandsen, Tove

    2008-01-01

    The paper introduces a new journal impact measure called The Reference Return Ratio (3R). Unlike the traditional Journal Impact Factor (JIF), which is based on calculations of publications and citations, the new measure is based on calculations of bibliographic investments (references) and returns...... (citations). A comparative study of the two measures shows a strong relationship between the 3R and the JIF. Yet, the 3R appears to correct for citation habits, citation dynamics, and composition of document types - problems that typically are raised against the JIF. In addition, contrary to traditional...

  9. The Returns to Entrepreneurship

    DEFF Research Database (Denmark)

    Van Praag, Mirjam; Raknerud, Arvid

    Empirical studies show low pecuniary returns of switching from wage employment to entrepreneurship. We reconsider the pecuniary gains of this switching by employing a two-stage procedure, where the randomness in the timing of inheritance transfers is used as an exclusion restriction to identify...... causal effects. The model is estimated on data covering the whole Norwegian population of individuals matched to the entire population of firms established in the period 2002-2011. The results indicate that the average returns to entrepreneurship are significantly negative for individuals entering...... entrepreneurship through self-employment and modest, but significantly positive, for incorporated startups....

  10. Return to nucleate boiling

    International Nuclear Information System (INIS)

    Shumway, R.W.

    1985-01-01

    This paper presents a collection of TMIN (temperature of return to nucleate boiling) correlations, evaluates them under several conditions, and compares them with a wide range of data. Purpose is to obtain the best one for use in a water reactor safety computer simulator known as TRAC-B. Return to nucleate boiling can occur in a reactor accident at either high or low pressure and flow rates. Most of the correlations yield unrealistic results under some conditions. A new correlation is proposed which overcomes many of the deficiencies

  11. Effects of 5-fluorouracil on biological characteristics and drug resistance mechanisms of liver cancer cell line PLC/RAF/5

    Directory of Open Access Journals (Sweden)

    CHENG Kangwen

    2015-09-01

    Full Text Available ObjectiveTo study the changes in biological characteristics of a liver cancer cell line PLC/RAF/5 after repeated exposure to a chemotherapy drug, 5-fluorouraci (5-FU, and to investigate the relationship between drug-resistant liver cancer cells and liver cancer stem cells. MethodsA low concentration of 5-FU (1 μg/ml was used to treat the human liver cancer cell line PLC/RAF/5 repeatedly to establish the PLC/RAF/5/5-FU cell line. Morphological differences between the two types of cells were observed. The inhibitory effects of different concentrations of 5-FU (0, 0.25, 0.5, 1, 1.5, and 2 μg/ml on the proliferation of the two types of cells were determined using the CCK-8 assay. Apoptosis of the two types of cells after exposure to different concentrations of 5-FU (0.5, 1, and 2 μg/ml for 48 h was analyzed using flow cytometry. The proportions of side population cells in both types of cells were measured using flow cytometry. The colony-forming ability was compared between the two types of cells by the plate colony-forming assay. The expression of Bax, Bcl-2, ABCG2, and FoxM1 proteins in both types of cells was examined by Western blot. Between-group comparison was performed by t test. ResultsThe PLC/RAF/5/5-FU cell line was successfully established using the chemotherapy drug 5-FU. Compared with the PLC/RAF/5 cells, the PLC/RAF/5/5-FU cells had a larger volume, fewer protrusions, a changed shape of a long shuttle, and enhanced refractivity. Moreover, compared with the parent cells, the PLC/RAF/5/5-FU cells had a significantly lower sensitivity to the inhibitory effect of 5-FU on proliferation, a significantly lower proportion of cells at the G0/G1 phase of the cell cycle, significantly higher proportions of cells at the S and G2/M phases, significantly higher resistance to apoptosis, a significantly higher proportion of side population cells, and significantly enhanced proliferation (P<0.05. According to the results of Western blot assay, the

  12. Migrational Characteristics, Biological Observations, and Relative Survival of Juvenile Salmonids Entering the Columbia River Estuary, 1966-1983, 1985 Final Report of Research.

    Energy Technology Data Exchange (ETDEWEB)

    Dawley, Earl M.

    1986-04-01

    Natural runs of salmonids in the Columbia River basin have decreased as a result of hydroelectric-dam development, poor land- and forest-management, and over-fishing. This has necessitated increased salmon culture to assure adequate numbers of returning adults. Hatchery procedures and facilities are continually being modified to improve both the efficiency of production and the quality of juveniles produced. Initial efforts to evaluate changes in hatchery procedures were dependent upon adult contributions to the fishery and returns to the hatchery. Procedures were developed for sampling juvenile salmon and steelhead entering the Columbia River estuary and ocean plume. The sampling of hatchery fish at the terminus of their freshwater migration assisted in evaluating hatchery production techniques and identifying migrational or behavioral characteristics that influence survival to and through the estuary. The sampling program attempted to estimate survival of different stocks and define various aspects of migratory behavior in a large river, with flows during the spring freshet from 4 to 17 thousand cubic meters per second (m/sup 3//second).

  13. Sustainable Mars Sample Return

    Science.gov (United States)

    Alston, Christie; Hancock, Sean; Laub, Joshua; Perry, Christopher; Ash, Robert

    2011-01-01

    The proposed Mars sample return mission will be completed using natural Martian resources for the majority of its operations. The system uses the following technologies: In-Situ Propellant Production (ISPP), a methane-oxygen propelled Mars Ascent Vehicle (MAV), a carbon dioxide powered hopper, and a hydrogen fueled balloon system (large balloons and small weather balloons). The ISPP system will produce the hydrogen, methane, and oxygen using a Sabatier reactor. a water electrolysis cell, water extracted from the Martian surface, and carbon dioxide extracted from the Martian atmosphere. Indigenous hydrogen will fuel the balloon systems and locally-derived methane and oxygen will fuel the MAV for the return of a 50 kg sample to Earth. The ISPP system will have a production cycle of 800 days and the estimated overall mission length is 1355 days from Earth departure to return to low Earth orbit. Combining these advanced technologies will enable the proposed sample return mission to be executed with reduced initial launch mass and thus be more cost efficient. The successful completion of this mission will serve as the next step in the advancement of Mars exploration technology.

  14. Return of qualified Sudanese

    OpenAIRE

    Lindsay T McMahon

    2007-01-01

    With the signing of the Comprehensive Peace Agreement in January 2005, the new Government of South Sudan began to call for the return of the millions of South Sudanese IDP s and refugees. The International Organization for Migration (IOM) has developed a programme to help them do so.

  15. Return of qualified Sudanese

    Directory of Open Access Journals (Sweden)

    Lindsay T McMahon

    2007-07-01

    Full Text Available With the signing of the Comprehensive Peace Agreement in January 2005, the new Government of South Sudan began to call for the return of the millions of South Sudanese IDP s and refugees. The International Organization for Migration (IOM has developed a programme to help them do so.

  16. Higher Education Endowments Return

    Science.gov (United States)

    Bahlmann, David; Walda, John D.; Sedlacek, Verne O.

    2012-01-01

    A new study of endowments by the National Association of College and University Business Officers (NACUBO) and the Commonfund Institute has brought good news to college and universities: While endowment returns dropped precipitously in fiscal year 2009 as a result of the financial crisis and accompanying slide in equity markets, they climbed to an…

  17. Return to Play

    Science.gov (United States)

    Mangan, Marianne

    2013-01-01

    Call it physical activity, call it games, or call it play. Whatever its name, it's a place we all need to return to. In the physical education, recreation, and dance professions, we need to redesign programs to address the need for and want of play that is inherent in all of us.

  18. The Returns on Investment Grade Diamonds

    NARCIS (Netherlands)

    Renneboog, L.D.R.

    2013-01-01

    Abstract: This paper examines the risk-return characteristics of investment grade gems (white diamonds, colored diamonds and other types of gems including sapphires, rubies, and emeralds). The transactions are coming from gem auctions and span the period 1999-2012. Over our time frame, the annual

  19. Biological nutrient removal and molecular biological characteristics in an anaerobic-multistage anaerobic/oxic (A-MAO) process to treat municipal wastewater.

    Science.gov (United States)

    Huang, Xiao; Dong, Wenyi; Wang, Hongjie; Jiang, Shilong

    2017-10-01

    This study aimed to present an anaerobic-multistage anaerobic/oxic (A-MAO) process to treat municipal wastewater. The average COD, NH 4 + -N, TN, and TP removal efficiency were 91.81%, 96.26%, 83.73% and 94.49%, respectively. Temperature plunge and C/N decrease have a certain impact on the modified process. Characteristics of microbial community, function microorganism, and correlation of microbial community with environmental variables in five compartments were carried out by Illumina Miseq high-throughput sequencing. The differences of microbial community were observed and Blastocatella, Flavobacterium and Pseudomonas were the dominant genus. Nitrosomonas and Nitrospira occupied a dominant position in AOB and NOB, respectively. Rhodospirillaceae and Rhodocyclaceae owned a considerable proportion in phosphorus removal bacteria. DO and COD played significant roles on affecting the microbial components. The A-MAO process in this study demonstrated a high potential for nutrient removal from municipal wastewater. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Patient Characteristics, Health Care Resource Utilization, and Costs Associated with Treatment-Regimen Failure with Biologics in the Treatment of Psoriasis.

    Science.gov (United States)

    Foster, Shonda A; Zhu, Baojin; Guo, Jiaying; Nikai, Enkeleida; Ojeh, Clement; Malatestinic, William; Goldblum, Orin; Kornberg, Lori J; Wu, Jashin J

    2016-04-01

    Psoriasis is a chronic, incurable, and immune-mediated skin disorder that is characterized by erythematous scaly papules and plaques. Understanding of psoriasis at the molecular level has led to the development of biologic agents that target disease-specific inflammatory mediators in psoriatic lesions. Biologic agents have become important components of the psoriasis armamentarium, but some patients become refractory to these agents over time or fail to respond to subsequent biologics. To (a) evaluate demographic and clinical characteristics of psoriasis patients who have treatment patterns suggestive of failure to a newly initiated biologic agent (treatment-regimen failures) compared with those who do not (non-treatment-regimen failures) and (b) to assess health care-related resource utilization and costs in non-treatment-regimen failures and treatment-regimen failures. In this retrospective observational cohort study, patients were selected from the MarketScan claims database of commercially insured individuals and individuals with Medicare supplemental insurance. The index event was a newly initiated biologic agent for the treatment of psoriasis (etanercept, adalimumab, ustekinumab, or infliximab) between January 2010 and December 2011. The analysis included psoriasis patients aged ≥ 18 years with ≥ 1 prescription claim for a biologic and continuous enrollment 12 months pre- and post-index date. Patients with claims for a biologic in the pre-index period were excluded. Patients were divided into treatment-regimen-failure and non-treatment-regimen-failure groups based on their treatment patterns post-index date. The treatment-regimen-failure group included patients who switched to another biologic, discontinued the biologic without restarting, increased the dose of the biologic, or augmented treatment with a nontopical psoriasis medication during the post-index period. Between-group patient characteristics and medication use were compared using analysis of

  1. Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX? Colon Cancer Assay

    OpenAIRE

    Clark-Langone, Kim M; Sangli, Chithra; Krishnakumar, Jayadevi; Watson, Drew

    2010-01-01

    Abstract Background The Oncotype DX® Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary colon tumor tissue. Like the Oncotype DX Breast Cancer Assay, this is a high complexity, multi-analyte, reverse transcription (RT) polymerase chain reaction (PCR) assay that measures the expression levels of specific cancer-related genes. By capturing the biology unde...

  2. The Effects of Simultaneous Application of Different Organic and Biological Fertilizers on Quantitative and Qualitative Characteristics of Cucurbita pepo L.

    Directory of Open Access Journals (Sweden)

    M Jahan

    2013-08-01

    Full Text Available Understanding of relations and interactions between ecosystem’s components and plants is one of the main conditions for sustainable production of medicinal plants. To study the effect of simultaneous application of organic and biological fertilizers on yield and yield components of zucchini squash, a split plot arrangement of factors based on randomized complete block design with tree replications was used during 2009-10 growing season. The mainplot factor was the type of organic fertilizers, including 1-cow manure, 2-sheep manure, 3-chicken manure, 4-vermicompost and 5-control. The subplot factor was the biofertilizer (namely Nitragin, containing Azotobacter sp. , Azospirillum sp. and Pseudomonas sp., utilization. The results showed the positive but non significant effect of organic and biological fertilizers on yield and yield components of zucchini squash. Amongst the organic fertilizers, cow and chicken manure, have superiority compared the others. The highest seed oil and protein percent resulted in chicken manure, although there was not significant different between treatments due to seed oil percent. The positive effect of organic and biological fertilizers on seed yield was higher than fruit yield. Positive correlations found between fruit and seed yield, and between one fruit weight and one fruit seed weight (R2=0.72** and 0.56**, respectively. At a glance, cow manure solely application was better than its application with nitragin. Nitragin application has no significant effect on some traits, when utilized with sheep manure and vermicompost. The possibilities of antagonistic effect among organic and biological fertilizers needs to be more studied.

  3. Product return management

    DEFF Research Database (Denmark)

    Shaharudin, Mohd Rizaimy; Govindan, Kannan; Zailani, Suhaiza

    2017-01-01

    The aim of this study is to examine the extent to which product returns motivate manufacturing firms to adopt closed-loop supply chain activities that influence the effectiveness of reverse supply chains. The hypotheses have been tested using data from a sample of 150 environmental management...... system ISO 14001 certified manufacturing firms in Malaysia through the census sampling approach. The results of the empirical test using LISREL Version 8.70 for the structural equation modeling support the fundamental explanation of the influence of the institutional forces towards the adoption of closed...... eventually impacts the firm's effectiveness in the reverse supply chain. The findings also help managers to understand the factors that can improve the outcome of the adoption of closed-loop supply chain activities by intensifying the extent of involvement in product returns, which provides a valuable...

  4. Reintegration upon return: insights from Ecuadorian returnees from Spain

    OpenAIRE

    Mercier, Marion; David, Anda; Mahia, Ramón; De Arce, Rafael

    2016-01-01

    Using the ECM2 survey data on Ecuadorian migrants returning from Spain, we investigate the determinants of reintegration upon return. We study how the migration experience, but also the before- and after-migration characteristics, correlate with migrants’ outcomes upon return. We adopt a broad conception of reintegration, considering jointly labour market-related outcomes that proxy for structural reintegration and subjective indicators that provide insights on sociocultural reintegration. Th...

  5. Recontextualising Cellular Respiration in Upper Secondary Biology Education. Characteristics and Practicability of a Learning and Teaching Strategy

    NARCIS (Netherlands)

    Wierdsma, Menno; Knippels, Marie Christine; van Oers, Bert; Boersma, Kerst Th

    2016-01-01

    Since concepts may have different meanings in different contexts, students have to learn to recontextualise them, i.e. to adapt their meanings to a new context. It is unclear, however, what characteristics a learning and teaching strategy for recontextualising should have. The study aims to develop

  6. Recontextualising Cellular Respiration in Upper Secondary Biology Education. Characteristics and Practicability of a Learning and Teaching Strategy

    Science.gov (United States)

    Wierdsma, Menno; Knippels, Marie-Christine; van Oers, Bert; Boersma, Kerst

    2016-01-01

    Since concepts may have different meanings in different contexts, students have to learn to recontextualise them, i.e. to adapt their meanings to a new context. It is unclear, however, what characteristics a learning and teaching strategy for recontextualising should have. The study aims to develop such a learning and teaching strategy for…

  7. Recontextualising cellular respiration in upper secondary biology education: characteristics and practicability of a learning and teaching strategy

    NARCIS (Netherlands)

    Wierdsma, Menno; Knippels, Marie-Christine; Oers, Bert; Boersma, Kerst

    2016-01-01

    Since concepts may have different meanings in different contexts, students have to learn to recontextualise them, i.e. to adapt their meanings to a new context. It is unclear, however, what characteristics a learning and teaching strategy for recontextualising should have. The study aims to develop

  8. Concentration and characteristics of depleted uranium in water, air and biological samples collected in Serbia and Montenegro

    International Nuclear Information System (INIS)

    Jia Guogang; Belli, Maria; Sansone, Umberto; Rosamilia, Silvia; Gaudino, Stefania

    2005-01-01

    During the Balkan conflicts, in 1995 and 1999, depleted uranium (DU) rounds were employed and were left in the battlefield. Health concern is related to the risk arising from contamination of the environment with DU penetrators and dust. In order to evaluate the impact of DU on the environment and population in Serbia and Montenegro, radiological surveys of DU in water, air and biological samples were carried out over the period 27 October-5 November 2001. The uranium isotopic concentrations in biological samples collected in Serbia and Montenegro, mainly lichens and barks, were found to be in the range of 0.67-704 Bq kg -1 for 238 U, 0.48-93.9 Bq kg -1 for 234 U and 0.02-12.2 Bq kg -1 for 235 U, showing uranium levels to be higher than in the samples collected at the control sites. Moreover, 236 U was detectable in some of the samples. The isotopic ratios of 234 U/ 238 U showed DU to be detectable in many biological samples at all examined sites, especially in Montenegro, indicating widespread ground-surface DU contamination, albeit at very low level. The uranium isotopic concentrations in air obtained from the air filter samples collected in Serbia and Montenegro were found to be in the range of 1.99-42.1 μBq m -3 for 238 U, 0.96-38.0 μBq m -3 for 234 U, and 0.05-1.83 μBq m -3 for 235 U, being in the typical range of natural uranium values. Thus said, most of the air samples are DU positive, this fact agreeing well with the widespread DU contamination detected in the biological samples. The uranium concentrations in water samples collected in Serbia and Montenegro were found to be in the range of 0.40-21.9 mBq l -1 for 238 U, 0.27-28.1 mBq l -1 for 234 U, and 0.01-0.88 mBq l -1 for 235 U, these values being much lower than those in mineral water found in central Italy and below the WHO guideline for drinking water. From a radiotoxicological point of view, at this moment there is no significant radiological risk related to these investigated sites in terms of

  9. Concentration and characteristics of depleted uranium in water, air and biological samples collected in Serbia and Montenegro.

    Science.gov (United States)

    Jia, Guogang; Belli, Maria; Sansone, Umberto; Rosamilia, Silvia; Gaudino, Stefania

    2005-09-01

    During the Balkan conflicts, in 1995 and 1999, depleted uranium (DU) rounds were employed and were left in the battlefield. Health concern is related to the risk arising from contamination of the environment with DU penetrators and dust. In order to evaluate the impact of DU on the environment and population in Serbia and Montenegro, radiological surveys of DU in water, air and biological samples were carried out over the period 27 October-5 November 2001. The uranium isotopic concentrations in biological samples collected in Serbia and Montenegro, mainly lichens and barks, were found to be in the range of 0.67-704 Bqkg(-1) for (238)U, 0.48-93.9 Bqkg(-1) for (234)U and 0.02-12.2 Bqkg(-1) for (235)U, showing uranium levels to be higher than in the samples collected at the control sites. Moreover, (236)U was detectable in some of the samples. The isotopic ratios of (234)U/(238)U showed DU to be detectable in many biological samples at all examined sites, especially in Montenegro, indicating widespread ground-surface DU contamination, albeit at very low level. The uranium isotopic concentrations in air obtained from the air filter samples collected in Serbia and Montenegro were found to be in the range of 1.99-42.1 microBqm(-3) for (238)U, 0.96-38.0 microBqm(-3) for (234)U, and 0.05-1.83 microBqm(-3) for (235)U, being in the typical range of natural uranium values. Thus said, most of the air samples are DU positive, this fact agreeing well with the widespread DU contamination detected in the biological samples. The uranium concentrations in water samples collected in Serbia and Montenegro were found to be in the range of 0.40-21.9 mBql(-1) for (238)U, 0.27-28.1 mBql(-1) for (234)U, and 0.01-0.88 mBql(-1) for (235)U, these values being much lower than those in mineral water found in central Italy and below the WHO guideline for drinking water. From a radiotoxicological point of view, at this moment there is no significant radiological risk related to these investigated

  10. Determination of 222Rn and its physico-chemical and biological characteristics in aquifers of Toluca valley

    International Nuclear Information System (INIS)

    Hernandez, A.; Aranda, P.; Ceballos, S.; Cruz, D.; Jauregui, B.; Lopez, R.; Pena, P.; Salazar, S.; Segovia, N.; Tamez, E.

    1997-01-01

    In this work it is realized a geochemical study which includes the evaluation of 222 Rn concentration in drinking water wells at Toluca city and a spring water of Almoloya de Juarez municipality at State of mexico. the same is studied about evolution of 222 Rn concentration in water of the hydrating which supply it to those wells. the geochemical evaluation also covers the determination of major and minor elements or trace and the biological analysis of water. The study includes two seasonal cycles, the low water mark one and other the rainy for being able to evaluate the aquifers reloading effects in the water composition. (Author)

  11. Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years

    Science.gov (United States)

    Wang, Lingchong; Wang, Xiangyu; Wu, Hao; Liu, Rui

    2014-01-01

    Among the three main divisions of marine macroalgae (Chlorophyta, Phaeophyta and Rhodophyta), marine green algae are valuable sources of structurally diverse bioactive compounds and remain largely unexploited in nutraceutical and pharmaceutical areas. Recently, a great deal of interest has been developed to isolate novel sulfated polysaccharides (SPs) from marine green algae because of their numerous health beneficial effects. Green seaweeds are known to synthesize large quantities of SPs and are well established sources of these particularly interesting molecules such as ulvans from Ulva and Enteromorpha, sulfated rhamnans from Monostroma, sulfated arabinogalactans from Codium, sulfated galacotans from Caulerpa, and some special sulfated mannans from different species. These SPs exhibit many beneficial biological activities such as anticoagulant, antiviral, antioxidative, antitumor, immunomodulating, antihyperlipidemic and antihepatotoxic activities. Therefore, marine algae derived SPs have great potential for further development as healthy food and medical products. The present review focuses on SPs derived from marine green algae and presents an overview of the recent progress of determinations of their structural types and biological activities, especially their potential health benefits. PMID:25257786

  12. Qualitative and qualitative characteristics of milk thistle (Silybum marianum L. in response to organic, biological and chemical fertilizers

    Directory of Open Access Journals (Sweden)

    R. Yazdani Biuki

    2016-04-01

    Full Text Available In order to evaluate the effects of organic, biological and chemical fertilizers on yield and yield components of milk thistle (Silybum marianum L., an experiment was conducted at the Research Station of Ferdowsi University of Mashhad based on complete randomized block design with three replications and six treatments during year 2007. Treatments included inoculated seeds with Azotobacter, compost, vermicompost, combination of both Azotobacter and compost treatments, chemical NPK fertilizer and control (without any fertilizer. The traits such as number of branches per plant, plant height, number of inflorescences per plant, inflorescence diameter, number of seeds per capitol, 1000 seed weight, seed yield, biological yield, harvest index, oil percentage, silymarin percentage, silybin percentage, oil yield and silymarin yield were measured. The results showed that application of different types of organic fertilizers had no effect on yield components, but had significant effect on oil percentage of oil, silymarin and silybin of seed. Compost application resulted the highest oil percentage (20.1 compared to other treatments. There was no significant difference between control, chemical fertilizer, compost and Azotobacter treatments on silymarin percentage. In terms of silybin percentage, there was no significant difference between control, compost, Azotobacter and aztobacter+compost treatments. The chemical fertilizer treatment showed the lowest silybin percentage (16.4. There was a positive correlation between plant height and seed yield (r=0.68**. It seems that biofertilizers can consider as a replacement for chemical fertilizers in Milk thistle medicinal plant production.

  13. Biological and ecological characteristics of soft ticks (Ixodida: Argasidae and their impact for predicting tick and associated disease distribution

    Directory of Open Access Journals (Sweden)

    Vial L.

    2009-09-01

    Full Text Available As evidence of global changes is accumulating, scientists are challenged to detect distribution changes of vectors, reservoirs and pathogens caused by anthropogenic and/or environmental changes. Statistical and mathematical distribution models are emerging for ixodid hard ticks whereas no prediction has ever been developed for argasid ones. These last organisms remain unknown and under-reported; they differ from hard ticks by many structural, biological and ecological properties, which complicate direct adaptation of hard tick models. However, investigations on bibliographic resources concerning these ticks suggest that distribution modelling based on natural niche concept and using environmental factors especially climate is also possible, bearing in mind the scale of prediction and their specificities including their nidicolous lifestyle, an indiscriminate host feeding and a short bloodmeal duration, as well as a flexible development cycle through diapause periods.

  14. Dynamics of forest ecosystems regenerated on burned and harvested areas in mountain regions of Siberia: characteristics of biological diversity, structure and productivity

    Directory of Open Access Journals (Sweden)

    I. M. Danilin

    2016-12-01

    Full Text Available Complex estimation of forest ecosystems dynamics based on detailing characteristics of structure, growth and productivity of the stands and describing general geographical and biological management options for preserving their biodiversity and sustaining stability are discussed in the paper by describing examples of tree stands restored on burned and logged areas in mountain regions of Siberia. On vast areas in Siberia, characterized as sub-boreal, subarid and with a strongly continental climate, forests grow on seasonally frozen soils and in many cases are surrounded by vast steppe and forest-steppe areas and uplands. Developing criteria for sustainability of mountain forest ecosystems is necessary for forest resource management and conservation. It is therefore important to obtain complex biometric characteristics on forest stands and landscapes and to thoroughly study their structure, biological diversity and productivity. Morphometric methods, Weibull simulation and allometric equations were used to determine the dimensional hierarchies of coenopopulation individuals. Structure and productivity of the aboveground stand components were also studied.

  15. Comparison of biological and genomic characteristics between a newly isolated mink enteritis parvovirus MEV-LHV and an attenuated strain MEV-L.

    Science.gov (United States)

    Mao, Yaping; Wang, Jigui; Hou, Qiang; Xi, Ji; Zhang, Xiaomei; Bian, Dawei; Yu, Yongle; Wang, Xi; Liu, Weiquan

    2016-06-01

    A virus isolated from mink showing clinical signs of enteritis was identified as a high virulent mink enteritis parvovirus (MEV) based on its biological characteristics in vivo and in vitro. Mink, challenged with this strain named MEV-LHV, exhibited severe pathological lesions as compared to those challenged with attenuated strain MEV-L. MEV-LHV also showed higher infection and replication efficiencies in vitro than MEV-L. Sequence of the complete genome of MEV-LHV was determined and analyzed in comparison with those in GenBank, which revealed that MEV-LHV shared high homology with virulent strain MEV SD12/01, whereas MEV-L was closely related to Abashiri and vaccine strain MEVB, and belonged to a different branch of the phylogenetic tree. The genomes of the two strains differed by insertions and deletions in their palindromic termini and specific unique mutations (especially VP2 300) in coding sequences which may be involved in viral replication and pathogenicity. The results of this study provide a better understanding of the biological and genomic characteristics of MEV and identify certain regions and sites that may be involved in viral replication and pathogenicity.

  16. Mars Sample Return Architecture Overview

    Science.gov (United States)

    Edwards, C. D.; Vijendran, S.

    2018-04-01

    NASA and ESA are exploring potential concepts for a Sample Retrieval Lander and Earth Return Orbiter that could return samples planned to be collected and cached by the Mars 2020 rover mission. We provide an overview of the Mars Sample Return architecture.

  17. Market skewness risk and the cross section of stock returns

    DEFF Research Database (Denmark)

    Chang, B.Y.; Christoffersen, Peter; Jacobs, K.

    2013-01-01

    The cross section of stock returns has substantial exposure to risk captured by higher moments of market returns. We estimate these moments from daily Standard & Poor's 500 index option data. The resulting time series of factors are genuinely conditional and forward-looking. Stocks with high...... exposure to innovations in implied market skewness exhibit low returns on average. The results are robust to various permutations of the empirical setup. The market skewness risk premium is statistically and economically significant and cannot be explained by other common risk factors such as the market...... excess return or the size, book-to-market, momentum, and market volatility factors, or by firm characteristics....

  18. Return Migration to Mexico: Does Health Matter?

    Science.gov (United States)

    Arenas, Erika; Goldman, Noreen; Pebley, Anne R; Teruel, Graciela

    2015-12-01

    We use data from three rounds of the Mexican Family Life Survey to examine whether migrants in the United States returning to Mexico in the period 2005-2012 have worse health than those remaining in the United States. Despite extensive interest by demographers in health-related selection, this has been a neglected area of study in the literature on U.S.-Mexico migration, and the few results to date have been contradictory and inconclusive. Using five self-reported health variables collected while migrants resided in the United States and subsequent migration history, we find direct evidence of higher probabilities of return migration for Mexican migrants in poor health as well as lower probabilities of return for migrants with improving health. These findings are robust to the inclusion of potential confounders reflecting the migrants' demographic characteristics, economic situation, family ties, and origin and destination characteristics. We anticipate that in the coming decade, health may become an even more salient issue in migrants' decisions about returning to Mexico, given the recent expansion in access to health insurance in Mexico.

  19. Mechanical characteristic and biological behaviour of implanted and restorative bioglasses used in medicine and dentistry: A systematic review.

    Science.gov (United States)

    Lizzi, F; Villat, C; Attik, N; Jackson, P; Grosgogeat, B; Goutaudier, C

    2017-06-01

    Nowadays bioactive glasses are finding increasing applications in medical practice due to their ability to stimulate re-mineralisation. However, they are intrinsically brittle materials and the study of new compositions will open up new scenarios enhancing their mechanical properties and maintaining the high bioactivity for a broader range of applications. This systematic review aims to identify the relationship between the composition of bioactive glasses used in medical applications and their influence on the mechanical and biological properties. Various electronic databases (PubMed, Science Direct) were used for collecting articles on this subject. This research includes papers from January 2011 to March 2016. PRISMA guidelines for systematic review and meta-analysis have been used. 109 abstracts were collected and screened, 68 articles were read as relevant articles and a total of 22 papers were finally selected for this study. Most of the studies obtained enhanced mechanical properties and the conservation of bioactivity behaviours; although a lack of homogeneity in the characterization methods makes it difficult to compare data. New compositions of bioactive glasses incorporating specific ions and the addition in polymers will be the most important direction for future researches in developing new materials for medical applications and especially for dentistry. Copyright © 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  20. Biological characteristics of the MG-63 human osteosarcoma cells on composite tantalum carbide/amorphous carbon films.

    Directory of Open Access Journals (Sweden)

    Yin-Yu Chang

    Full Text Available Tantalum (Ta is a promising metal for biomedical implants or implant coating for orthopedic and dental applications because of its excellent corrosion resistance, fracture toughness, and biocompatibility. This study synthesizes biocompatible tantalum carbide (TaC and TaC/amorphous carbon (a-C coatings with different carbon contents by using a twin-gun magnetron sputtering system to improve their biological properties and explore potential surgical implant or device applications. The carbon content in the deposited coatings was regulated by controlling the magnetron power ratio of the pure graphite and Ta cathodes. The deposited TaC and TaC/a-C coatings exhibited better cell viability of human osteosarcoma cell line MG-63 than the uncoated Ti and Ta-coated samples. Inverted optical and confocal imaging was used to demonstrate the cell adhesion, distribution, and proliferation of each sample at different time points during the whole culture period. The results show that the TaC/a-C coating, which contained two metastable phases (TaC and a-C, was more biocompatible with MG-63 cells compared to the pure Ta coating. This suggests that the TaC/a-C coatings exhibit a better biocompatible performance for MG-63 cells, and they may improve implant osseointegration in clinics.

  1. The Return to Foreign Aid

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Hansen, Henrik

    2017-01-01

    We estimate the average rate of return on investments financed by aid and by domestic resource mobilisation, using aggregate data. Both returns are expected to vary across countries and time. Consequently we develop a correlated random coefficients model to estimate the average returns. Across...... different estimators and two different data sources for GDP and investment our findings are remarkably robust; the average gross return on ‘aid investments’ is about 20 per cent. This is in accord with micro estimates of the economic rate of return on aid projects and with aggregate estimates of the rate...

  2. Efeito do retorno de lodo aeróbio sobre as características da biomassa presente em reatores UASB tratando esgoto sanitário Effect of aerobic sludge return on the characteristics of anaerobic biomass present in UASB reactors treating domestic sewage

    Directory of Open Access Journals (Sweden)

    Patrícia Procópio Pontes

    2009-06-01

    Full Text Available O presente trabalho buscou avaliar a influência do retorno do lodo produzido em filtros biológicos percoladores (FBP sobre as características da biomassa em reatores UASB utilizados para o tratamento de esgoto sanitário. Os experimentos foram conduzidos em reatores em escala piloto e em escala de demonstração, sendo que os reatores UASB foram operados com e sem retorno do lodo produzido nos FBP. Os resultados obtidos indicaram uma diminuição no diâmetro das partículas de lodo, durante as fases com retorno de lodo, mas apenas para as amostras de lodo tomadas nos pontos mais altos dos reatores anaeróbios. A estabilidade e a atividade metanogênica específica do lodo anaeróbio praticamente não se modificaram com o retorno de lodo. Conforme esperado, a produção específica de lodo anaeróbio aumentou com o retorno de lodo.This work aimed at evaluating the influence of the return of excess aerobic sludge produced in trickling filters (TF upon the biomass characteristics in UASB reactors used for the treatment of domestic sewage. The experiments were carried out in pilot and demonstration-scale reactors, with the UASB reactors being operated with and without the return of sludge produced in the TF. Smaller sludge particle sizes were observed when the aerobic sludge was returned to the UASB reactor, but only for sludge samples collected in the upper parts of the anaerobic reactors. Sludge stability and specific methanogenic activity were not affected by the return of sludge. As expected, the specific anaerobic sludge production increased with the return of sludge.

  3. Using redescription mining to relate clinical and biological characteristics of cognitively impaired and Alzheimer’s disease patients

    Science.gov (United States)

    Mihelčić, Matej; Šimić, Goran; Babić Leko, Mirjana; Lavrač, Nada; Džeroski, Sašo; Šmuc, Tomislav

    2017-01-01

    Based on a set of subjects and a collection of attributes obtained from the Alzheimer’s Disease Neuroimaging Initiative database, we used redescription mining to find interpretable rules revealing associations between those determinants that provide insights about the Alzheimer’s disease (AD). We extended the CLUS-RM redescription mining algorithm to a constraint-based redescription mining (CBRM) setting, which enables several modes of targeted exploration of specific, user-constrained associations. Redescription mining enabled finding specific constructs of clinical and biological attributes that describe many groups of subjects of different size, homogeneity and levels of cognitive impairment. We confirmed some previously known findings. However, in some instances, as with the attributes: testosterone, ciliary neurotrophic factor, brain natriuretic peptide, Fas ligand, the imaging attribute Spatial Pattern of Abnormalities for Recognition of Early AD, as well as the levels of leptin and angiopoietin-2 in plasma, we corroborated previously debatable findings or provided additional information about these variables and their association with AD pathogenesis. Moreover, applying redescription mining on ADNI data resulted with the discovery of one largely unknown attribute: the Pregnancy-Associated Protein-A (PAPP-A), which we found highly associated with cognitive impairment in AD. Statistically significant correlations (p ≤ 0.01) were found between PAPP-A and clinical tests: Alzheimer’s Disease Assessment Scale, Clinical Dementia Rating Sum of Boxes, Mini Mental State Examination, etc. The high importance of this finding lies in the fact that PAPP-A is a metalloproteinase, known to cleave insulin-like growth factor binding proteins. Since it also shares similar substrates with A Disintegrin and the Metalloproteinase family of enzymes that act as α-secretase to physiologically cleave amyloid precursor protein (APP) in the non-amyloidogenic pathway, it could

  4. Connective tissue activation. XXXII. Structural and biologic characteristics of mesenchymal cell-derived connective tissue activating peptide-V.

    Science.gov (United States)

    Cabral, A R; Cole, L A; Walz, D A; Castor, C W

    1987-12-01

    Connective tissue activating peptide-V (CTAP-V) is a single-chain, mesenchymal cell-derived anionic protein with large and small molecular forms (Mr of 28,000 and 16,000, respectively), as defined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The proteins have similar specific activities with respect to stimulation of hyaluronic acid and DNA formation in human synovial fibroblast cultures. S-carboxymethylation or removal of sialic acid residues did not modify CTAP-V biologic activity. Rabbit antibodies raised separately against each of the purified CTAP-V proteins reacted, on immunodiffusion and on Western blot, with each antigen and neutralized mitogenic activity. The amino-terminal amino acid sequence of the CTAP-V proteins, determined by 2 laboratories, confirmed their structural similarities. The amino-terminal sequence through 37 residues was demonstrated for the smaller protein. The first 10 residues of CTAP-V (28 kd) were identical to the N-terminal decapeptide of CTAP-V (16 kd). The C-terminal sequence, determined by carboxypeptidase Y digestion, was the same for both CTAP-V molecular species. The 2 CTAP-V peptides had similar amino acid compositions, whether residues were expressed as a percent of the total or were normalized to mannose. Reduction of native CTAP-V protein released sulfhydryl groups in a protein:disulfide ratio of 1:2; this suggests that CTAP-V contains 2 intramolecular disulfide bonds. Clearly, CTAP-V is a glycoprotein. The carbohydrate content of CTAP-V (16 kd) and CTAP-V (28 kd) is 27% and 25%, respectively. CTAP-V may have significance in relation to autocrine mechanisms for growth regulation of connective tissue cells and other cell types.

  5. The 'successful' return

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2012-01-01

    Research on female migrant caregivers has tended to focus upon the emotional and social problems they encounter working abroad, given women’s traditional role as caregivers for their own families. This article analyses how Caribbean women who have returned after a period abroad as domestic workers...... inscribe their migration experiences within the gendered narrative of the good relative who migrates to help the family left behind and therefore deserves social recognition in the community of origin. It argues that this narrative allows the women to both affirm and reinterpret local family and gender...... roles within the context of migration. This analysis points to the close connection between narrative structures, accounts of migration experiences, and self-presentations and suggests that narratives about family and gender roles not only reflect people’s lives, but are also a malleable resource...

  6. Biomagnification of mercury through lake trout (Salvelinus namaycush) food webs of lakes with different physical, chemical and biological characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Kidd, Karen A., E-mail: kiddk@unbsj.ca [Canadian Rivers Institute and Biology Department, University of New Brunswick, Saint John, NB, Canada E2L 4L5 (Canada); Muir, Derek C.G., E-mail: derek.muir@ec.gc.ca [Aquatic Contaminants Research Division, Environment Canada, Burlington, ON, Canada L7R 4A6 (Canada); Evans, Marlene S., E-mail: marlene.evans@ec.gc.ca [Aquatic Contaminants Research Division, Environment Canada, Saskatoon, SK, Canada S7N 3H5 (Canada); Wang, Xioawa, E-mail: xiaowa.wang@ec.gc.ca [Aquatic Contaminants Research Division, Environment Canada, Burlington, ON, Canada L7R 4A6 (Canada); Whittle, Mike [Aquatic Contaminants Research Division, Environment Canada, Burlington, ON, Canada L7R 4A6 (Canada); Swanson, Heidi K., E-mail: heidikswanson@yahoo.ca [Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E9 (Canada); Johnston, Tom, E-mail: tjohnston@laurentian.ca [Cooperative Freshwater Ecology Unit, Ontario Ministry of Natural Resources, and Biology Department, Laurentian University, Sudbury, ON, Canada P3E 2C6 (Canada); Guildford, Stephanie, E-mail: sguildfo@d.umn.edu [Department of Biology and Large Lakes Observatory, University of Minnesota Duluth, 2205 5th St., Duluth, MN, 55812 (United States)

    2012-11-01

    Mercury (Hg) biomagnification in aquatic ecosystems remains a concern because this pollutant is known to affect the health of fish-eating wildlife and humans, and the fish themselves. The 'rate' of mercury biomagnification is being assessed more frequently using stable nitrogen isotope ratios ({delta}{sup 15}N), a measure of relative trophic position of biota within a food web. Within food webs and across diverse systems, log-transformed Hg concentrations are significantly and positively related to {delta}{sup 15}N and the slopes of these models vary from one study to another for reasons that are not yet understood. Here we compared the rates of Hg biomagnification in 14 lake trout lakes from three provinces in Canada to understand whether any characteristics of the ecosystems explained this among-system variability. Several fish species, zooplankton and benthic invertebrates were collected from these lakes and analyzed for total Hg (fish only), methyl Hg (invertebrates) and stable isotopes ({delta}{sup 15}N; {delta}{sup 13}C to assess energy sources). Mercury biomagnification rates varied significantly across systems and were higher for food webs of larger (surface area), higher nutrient lakes. However, the slopes were not predictive of among-lake differences in Hg in the lake trout. Results indicate that among-system differences in the rates of Hg biomagnification seen in the literature may be due, in part, to differences in ecosystem characteristics although the mechanisms for this variability are not yet understood. -- Highlights: Black-Right-Pointing-Pointer Mercury biomagnifies through aquatic food webs to toxic levels in top predator fishes. Black-Right-Pointing-Pointer Among-system differences in mercury transfer through food webs occur but have not been explained. Black-Right-Pointing-Pointer Diverse lakes supporting lake trout were compared to understand the ecosystem processes that affect mercury biomagnification. Black

  7. Genotypic and biological characteristics of non-identified strain of spotted fever group rickettsiae isolated in Crimea.

    Science.gov (United States)

    Balayeva, N M; Demkin, V V; Rydkina, E B; Ignatovich, V F; Artemiev, M I; Lichoded LYa; Genig, V A

    1993-12-01

    A strain of rickettsiae, designated Crimea-108, was isolated from ticks Dermacentor marginatus in the Crimea in 1977. Its immunobiological characteristics involve low pathogenicity for experimental animals, moderate infectivity for chick embryos, and antigenic relatedness to spotted fever group (SFG) rickettsiae (R. sibirica, R. conorii, R. akari), especially to R. sibirica. The genotypic characterization of the strain Crimea-108 was carried out in comparison with SFG and typhus group rickettsiae by using restriction fragment length polymorphism (RFLP) analysis and DNA-probe hybridization. The marked similarity was detected between DNA restriction patterns of the strains Crimea-108, R. sibirica and R. conorii, but each of them besides comigrating fragments had specific ones. Genotypic analysis of the strain Crimea-108, the SFG and typhus group rickettsiae by three independent DNA probes, based on R. prowazekii DNA, gave unique hybridization patterns for the Crimea-108 strain with all probes. The obtained data show that the Crimea-108 isolate does not belong to the species of R. sibirica, R. conorii, R. akari. The strain Crimea-108 is a novel strain of SFG rickettsiae for the Crimea region.

  8. Biological characteristics and probiotic effect of Leuconostoc lactis strain isolated from the intestine of black porgy fish

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2013-09-01

    Full Text Available A strain of lactic acid bacteria, Leuconostoc lactis, was isolated from the intestinal tract of black porgy, Sparus macrocephalus, and identified by conventional biochemical characteristics and 16S rDNA gene sequence analysis. The isolated strain had the ability of bile tolerance and resistance to low pH, and survived well in the trypsinase and pepsin solution. But the highly concentrated dose of trypsinase and pepsin affect the viability of the isolated strain. The isolate was resistant to several antibiotics, including Cephalothin, Ceftriaxone, Imipenem and Tobramycin. The isolate could autoaggregate itself and coaggregate with other bacteria in vitro. The autoaggregation percentage increased to 23.29% after 20 h of incubation. The percentage of coaggregation were respectively 31.21%, 29.44%, 10.74%, 16.49%, 24.36%, 24.41% and 20.99% for Vibrio parahaemolyticus, Listeria monocytogenes, Escherichia coli O157, Salmonella typhimurium, Shigella, Staphylococcus aureus and Proteusbacillus vulgaris after 20 h incubation of a mixed suspension. The supernatant of the strain inhibited the growth of several pathogens, such as V.parahaemolyticus, Vibrio harveyi, Vibrio alginolyticus, Staphylococcus aureus, Escherichia coli O157, Salmonella typhimurium, Bacillus subtilis, Proteusbacillus vulgaris and Shigella. These results indicated that the isolate, Leuconostoc lactis, might be an attractive candidate for perspectival strain for probiotics in marine aquaculture.

  9. Systematic analysis of compositional order of proteins reveals new characteristics of biological functions and a universal correlate of macroevolution.

    Directory of Open Access Journals (Sweden)

    Erez Persi

    Full Text Available We present a novel analysis of compositional order (CO based on the occurrence of Frequent amino-acid Triplets (FTs that appear much more than random in protein sequences. The method captures all types of proteomic compositional order including single amino-acid runs, tandem repeats, periodic structure of motifs and otherwise low complexity amino-acid regions. We introduce new order measures, distinguishing between 'regularity', 'periodicity' and 'vocabulary', to quantify these phenomena and to facilitate the identification of evolutionary effects. Detailed analysis of representative species across the tree-of-life demonstrates that CO proteins exhibit numerous functional enrichments, including a wide repertoire of particular patterns of dependencies on regularity and periodicity. Comparison between human and mouse proteomes further reveals the interplay of CO with evolutionary trends, such as faster substitution rate in mouse leading to decrease of periodicity, while innovation along the human lineage leads to larger regularity. Large-scale analysis of 94 proteomes leads to systematic ordering of all major taxonomic groups according to FT-vocabulary size. This is measured by the count of Different Frequent Triplets (DFT in proteomes. The latter provides a clear hierarchical delineation of vertebrates, invertebrates, plants, fungi and prokaryotes, with thermophiles showing the lowest level of FT-vocabulary. Among eukaryotes, this ordering correlates with phylogenetic proximity. Interestingly, in all kingdoms CO accumulation in the proteome has universal characteristics. We suggest that CO is a genomic-information correlate of both macroevolution and various protein functions. The results indicate a mechanism of genomic 'innovation' at the peptide level, involved in protein elongation, shaped in a universal manner by mutational and selective forces.

  10. Systematic Analysis of Compositional Order of Proteins Reveals New Characteristics of Biological Functions and a Universal Correlate of Macroevolution

    Science.gov (United States)

    Persi, Erez; Horn, David

    2013-01-01

    We present a novel analysis of compositional order (CO) based on the occurrence of Frequent amino-acid Triplets (FTs) that appear much more than random in protein sequences. The method captures all types of proteomic compositional order including single amino-acid runs, tandem repeats, periodic structure of motifs and otherwise low complexity amino-acid regions. We introduce new order measures, distinguishing between ‘regularity’, ‘periodicity’ and ‘vocabulary’, to quantify these phenomena and to facilitate the identification of evolutionary effects. Detailed analysis of representative species across the tree-of-life demonstrates that CO proteins exhibit numerous functional enrichments, including a wide repertoire of particular patterns of dependencies on regularity and periodicity. Comparison between human and mouse proteomes further reveals the interplay of CO with evolutionary trends, such as faster substitution rate in mouse leading to decrease of periodicity, while innovation along the human lineage leads to larger regularity. Large-scale analysis of 94 proteomes leads to systematic ordering of all major taxonomic groups according to FT-vocabulary size. This is measured by the count of Different Frequent Triplets (DFT) in proteomes. The latter provides a clear hierarchical delineation of vertebrates, invertebrates, plants, fungi and prokaryotes, with thermophiles showing the lowest level of FT-vocabulary. Among eukaryotes, this ordering correlates with phylogenetic proximity. Interestingly, in all kingdoms CO accumulation in the proteome has universal characteristics. We suggest that CO is a genomic-information correlate of both macroevolution and various protein functions. The results indicate a mechanism of genomic ‘innovation’ at the peptide level, involved in protein elongation, shaped in a universal manner by mutational and selective forces. PMID:24278003

  11. Computing return times or return periods with rare event algorithms

    Science.gov (United States)

    Lestang, Thibault; Ragone, Francesco; Bréhier, Charles-Edouard; Herbert, Corentin; Bouchet, Freddy

    2018-04-01

    The average time between two occurrences of the same event, referred to as its return time (or return period), is a useful statistical concept for practical applications. For instance insurances or public agencies may be interested by the return time of a 10 m flood of the Seine river in Paris. However, due to their scarcity, reliably estimating return times for rare events is very difficult using either observational data or direct numerical simulations. For rare events, an estimator for return times can be built from the extrema of the observable on trajectory blocks. Here, we show that this estimator can be improved to remain accurate for return times of the order of the block size. More importantly, we show that this approach can be generalised to estimate return times from numerical algorithms specifically designed to sample rare events. So far those algorithms often compute probabilities, rather than return times. The approach we propose provides a computationally extremely efficient way to estimate numerically the return times of rare events for a dynamical system, gaining several orders of magnitude of computational costs. We illustrate the method on two kinds of observables, instantaneous and time-averaged, using two different rare event algorithms, for a simple stochastic process, the Ornstein–Uhlenbeck process. As an example of realistic applications to complex systems, we finally discuss extreme values of the drag on an object in a turbulent flow.

  12. Evaluation of diagnostic procedures such as plain-film scintigraphy and MR imaging for spinal metastases in relation to biological characteristics in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Hiroya; Nagao, Kazuharu; Nishimura, Reiki; Matsuda, Kazumasa; Baba, Kenichiro; Matsuoka, Yukio; Fukuda, Makoto; Higuchi, Akihiro; Saeki, Takahito [Kumamoto City Hospital (Japan)

    1995-09-01

    The relationship between spinal metastases diagnosed by plain-film, bone scintigraphy, and MR imaging and biological characteristics in 26 patients with breast cancer was investigated retrospectively. It was found that bone scintigraphy is useful for detecting metastases in case with slow-growing tumors determined by DNA polymerase {alpha} or with estrogen-receptor (ER) positivity. In contrast, cases with rapidly growing tumors showed false-negative plain-film or bone scintigraphy results, including cases with ER-negative tumors or DNA polymerase {alpha} of more than 20%. MR imaging was found to be highly sensitive in detecting spinal metastases even in aggressive cases. MR imaging was found to have greater reliability in detecting spinal metastases of breast cancer compared to bone scintigraphy. In conclusion, it may be important to consider the degree of malignancy of each case with spinal metastases of breast cancer in evaluating imaging diagnosis. (author).

  13. Evaluation of diagnostic procedures such as plain-film scintigraphy and MR imaging for spinal metastases in relation to biological characteristics in breast cancer

    International Nuclear Information System (INIS)

    Yamashita, Hiroya; Nagao, Kazuharu; Nishimura, Reiki; Matsuda, Kazumasa; Baba, Kenichiro; Matsuoka, Yukio; Fukuda, Makoto; Higuchi, Akihiro; Saeki, Takahito

    1995-01-01

    The relationship between spinal metastases diagnosed by plain-film, bone scintigraphy, and MR imaging and biological characteristics in 26 patients with breast cancer was investigated retrospectively. It was found that bone scintigraphy is useful for detecting metastases in case with slow-growing tumors determined by DNA polymerase α or with estrogen-receptor (ER) positivity. In contrast, cases with rapidly growing tumors showed false-negative plain-film or bone scintigraphy results, including cases with ER-negative tumors or DNA polymerase α of more than 20%. MR imaging was found to be highly sensitive in detecting spinal metastases even in aggressive cases. MR imaging was found to have greater reliability in detecting spinal metastases of breast cancer compared to bone scintigraphy. In conclusion, it may be important to consider the degree of malignancy of each case with spinal metastases of breast cancer in evaluating imaging diagnosis. (author)

  14. Selected Hydrologic, Water-Quality, Biological, and Sedimentation Characteristics of Laguna Grande, Fajardo, Puerto Rico, March 2007-February 2009

    Science.gov (United States)

    Soler-López, Luis R.; Santos, Carlos R.

    2010-01-01

    Laguna Grande is a 50-hectare lagoon in the municipio of Fajardo, located in the northeasternmost part of Puerto Rico. Hydrologic, water-quality, and biological data were collected in the lagoon between March 2007 and February 2009 to establish baseline conditions and determine the health of Laguna Grande on the basis of preestablished standards. In addition, a core of bottom material was obtained at one site within the lagoon to establish sediment depositional rates. Water-quality properties measured onsite (temperature, pH, dissolved oxygen, specific conductance, and water transparency) varied temporally rather than areally. All physical properties were in compliance with current regulatory standards established for Puerto Rico. Nutrient concentrations were very low and in compliance with current regulatory standards (less than 5.0 and 1.0 milligrams per liter for total nitrogen and total phosphorus, respectively). The average total nitrogen concentration was 0.28 milligram per liter, and the average total phosphorus concentration was 0.02 milligram per liter. Chlorophyll a was the predominant form of photosynthetic pigment in the water. The average chlorophyll-a concentration was 6.2 micrograms per liter. Bottom sediment accumulation rates were determined in sediment cores by modeling the downcore activities of lead-210 and cesium-137. Results indicated a sediment depositional rate of about 0.44 centimeter per year. At this rate of sediment accretion, the lagoon may become a marshland in about 700 to 900 years. About 86 percent of the community primary productivity in Laguna Grande was generated by periphyton, primarily algal mats and seagrasses, and the remaining 14 percent was generated by phytoplankton in the water column. Based on the diel studies the total average net community productivity equaled 5.7 grams of oxygen per cubic meter per day (2.1 grams of carbon per cubic meter per day). Most of this productivity was ascribed to periphyton and macrophytes

  15. Side-by-Side Comparison of the Biological Characteristics of Human Umbilical Cord and Adipose Tissue-Derived Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    Li Hu

    2013-01-01

    Full Text Available Both human adipose tissue-derived mesenchymal stem cells (ASCs and umbilical cord-derived mesenchymal stem cells (UC-MSCs have been explored as attractive mesenchymal stem cells (MSCs sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative study by isolating MSCs from the adipose tissue and umbilical cords from mothers delivering full-term babies and thus compared the various biological aspects of ASCs and UC-MSCs derived from the same individual, in one study. Both types of cells expressed cell surface markers characteristic of MSCs. ASCs and UC-MSCs both could be efficiently induced into adipocytes, osteoblasts, and neuronal phenotypes. While there were no significant differences in their osteogenic differentiation, the adipogenesis of ASCs was more prominent and efficient than UC-MSCs. In the meanwhile, ASCs responded better to neuronal induction methods, exhibiting the higher differentiation rate in a relatively shorter time. In addition, UC-MSCs exhibited a more prominent secretion profile of cytokines than ASCs. These results indicate that although ASCs and UC-MSCs share considerable similarities in their immunological phenotype and pluripotentiality, certain biological differences do exist, which might have different implications for future cell-based therapy.

  16. Effects of removing Good Hope Mill Dam on selected physical, chemical, and biological characteristics of Conodoguinet Creek, Cumberland County, Pennsylvania

    Science.gov (United States)

    Chaplin, Jeffrey J.; Brightbill, Robin A.; Bilger, Michael D.

    2005-01-01

    The implications of dam removal on channel characteris-tics, water quality, benthic invertebrates, and fish are not well understood because of the small number of removals that have been studied. Comprehensive studies that document the effects of dam removal are just beginning to be published, but most research has focused on larger dams or on the response of a sin-gle variable (such as benthic invertebrates). This report, pre-pared in cooperation with the Conodoguinet Creek Watershed Association, provides an evaluation of how channel morphol-ogy, bed-particle-size distribution, water quality, benthic inver-tebrates, fish, and aquatic habitat responded after removal of Good Hope Mill Dam (a small 'run of the river' dam) from Conodoguinet Creek in Cumberland County, Pa. Good Hope Mill Dam was a 6-foot high, 220-foot wide concrete structure demolished and removed over a 3-day period beginning with the initial breach on November 2, 2001, at 10:00 a.m. eastern standard time. To isolate the effects of dam removal, data were collected before and after dam removal at five monitoring stations and over selected reaches upstream, within, and downstream of the impoundment. Stations 1, 2, and 5 were at free-flowing control locations 4.9 miles upstream, 2.5 miles upstream, and 5 miles downstream of the dam, respec-tively. Stations 3 and 4 were located where the largest responses were anticipated, 115 feet upstream and 126 feet downstream of the dam, respectively Good Hope Mill Dam was not an effective barrier to sedi-ment transport. Less than 3 inches of sediment in the silt/clay-size range (less than 0.062 millimeters) coated bedrock within the 7,160-foot (1.4-mile) impoundment. The bedrock within the impoundment was not incised during or after dam removal, and the limited sediment supply resulted in no measurable change in the thalweg elevation downstream of the dam. The cross-sec-tional areas at stations 3 and 4, measured 17 days and 23 months after dam removal, were within

  17. Return to the... past

    International Nuclear Information System (INIS)

    Ammerich, M.

    2009-01-01

    This article goes back over the incidents occurring during the summer 2008, that is to say the uranium release from the Socatri facility in the South of France. From this point, the purpose studies the radiological situation of the Camargue seashore; the levels of radioactivity are from 3 to thirty times higher than these ones expected in this area, but the natural radioactivity with thorium and uranium coming from the granitic massifs erosion brings an important part. It is difficult to make the part between human and natural contribution to ambient radioactivity. However, it appears that to limit the water consumption until the time of dilution played its part was absolutely necessary. Then, because it is question of water, the drinking water is tackled. Some mineral waters go over the recommended limits of doses. A last return to the past with the radioactive watches, but this time with actual watches that activate detection. Two watches contained promethium 147, 147 Pm is a beta emitter but also gamma emitter. To end, in Ireland and Great Britain, some fire detectors contain americium 241. In fact, this article constitutes a summary of different abnormalities around radioactivity. (N.C.)

  18. The return of religion

    Directory of Open Access Journals (Sweden)

    S. Griffioen

    2011-06-01

    Full Text Available Religion is back in Philosophy as a respectable subject. Part 1 first charts what MacIntyre, Taylor and Derrida have meant in this regard. Subsequently, it turns to the Enlightenment to determine what constituted the breakthrough. It is found that even where the Enlightenment gave maximum room to religion i.e. as a civic religion and as “religion of the heart” it still excluded a constitutive relation to a transcendent revelation. Part 2 centres on the religion-faith distinction in reformational philosophy. Similar to the Enlightenment, religion is understood as part of human nature. However, human nature itself is conceived as intrinsically religious and depending for its light on revelation. Secondly, “religion” in this context also encompasses idols and religious substitutes. Thus, it directs attention to shopping malls, football stadiums, health policy, et cetera, as possible contexts of a return of religion. Examples show that this has become a popular approach. However, most of the publications surveyed fail to distinguish between an “analogical” and a “pistically qualified” use of religion, and are open to exaggerations (the shopping mall and football stadiums as temples, etc.. At this junction, the relevance is shown of the religion-faith distinction as well as of Elaine Botha’s theory of metaphors. The epilogue offers an integration of parts one and two.

  19. PUC fast track nips returns

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    In the first of what it says will be annual cost-of-capital proceedings to set returns on equity and rates of return on rate base for electric utilities, the California Public Utilities Commission (PUC) lowered from 1989 levels the 1990 returns on common equity (ROE) and rates of return (ROR) for the state's four major investor-owned electric utilities. Under this fast-track procedure, by May 8 of every year, utilities will have to file an application for rate adjustments that reflect their projected costs of capital for the following year

  20. The return to foreign aid

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Hansen, Henrik

    We investigate the marginal productivity of investment across countries. The aim is to estimate the return on investments financed by foreign aid and by domestic resource mobilization, using aggregate data. Both returns are expected to vary across countries and time. Consequently we develop...... a correlated random coefficients model, to estimate the average aggregate return on ‘aid investments’ and ‘domestic investments’. Across different estimators and two different sources for GDP and investment data our findings are remarkably robust; the average gross return on ‘aid investments’ is about 20 per...

  1. Racial and Ethnic Disparity in Symptomatic Breast Cancer Awareness despite a Recent Screen: The Role of Tumor Biology and Mammography Facility Characteristics.

    Science.gov (United States)

    Mortel, Mylove; Rauscher, Garth H; Murphy, Anne Marie; Hoskins, Kent; Warnecke, Richard B

    2015-10-01

    In a racially and ethnically diverse sample of recently diagnosed urban patients with breast cancer, we examined associations of patient, tumor biology, and mammography facility characteristics on the probability of symptomatic discovery of their breast cancer despite a recent prior screening mammogram. In the Breast Cancer Care in Chicago study, self-reports at interview were used to define patients as having a screen-detected breast cancer or having symptomatic awareness despite a recent screening mammogram (SADRS), in the past 1 or 2 years. Patients with symptomatic breast cancer who did not report a recent prior screen were excluded from these analyses. Characteristics associated with more aggressive disease [estrogen receptor (ER)- and progesterone receptor (PR)-negative status and higher tumor grade] were abstracted from medical records. Mammogram facility characteristics that might indicate aspects of screening quality were defined and controlled for in some analyses. SADRS was more common among non-Hispanic black and Hispanic than among non-Hispanic white patients (36% and 42% vs. 25%, respectively, P = 0.0004). SADRS was associated with ER/PR-negative and higher-grade disease. Patients screened at sites that relied on dedicated radiologists and sites that were breast imaging centers of excellence were less likely to report SADRS. Tumor and facility factors together accounted for two thirds of the disparity in SADRS (proportion mediated = 70%, P = 0.02). Facility resources and tumor aggressiveness explain much of the racial/ethnic disparity in symptomatic breast cancer among recently screened patients. A more equitable distribution of high-quality screening would ameliorate but not eliminate this disparity. ©2015 American Association for Cancer Research.

  2. Corporate Governance and Equity Returns

    OpenAIRE

    Uchida, Shigeru

    2012-01-01

    This paper analyses the relationship between corporate governance and equity returns from the small investors view point. A primary survey has been conducted to gather the data required to examine the link. Preliminary result of the study shows that the four elements of governance: board structure, transparency, fairness and responsibility are positively related with equity returns.

  3. The relationship between biological cognitive and psychosocial characteristics of parents and the weight of infant at the time of birth in Isfahan.

    Science.gov (United States)

    Talebian, Mohammad Hassan; Afrooz, Gholam Ali; Hooman, Heidar Ali; Aghaei, Asghar

    2013-01-01

    The present study was connected in order to evaluate the relationship between biological, cognitive and psychosocial characteristics of mothers and the weight of infant at the time of birth. In order to conduct this research a sample of 910 women among recently delivered mothers of Isfahan province in 2009 were selected. From stratified sampling and cluster sampling according to the percentage of population in each of the cities of Isfahan Province was used. The data was gathered with a questionnaire prepared by the researcher in order to evaluate the biological cognitive and psychosocial characteristics of mothers, in addition to the Enrich marital satisfaction test. After collecting data, the analysis of the data was done with SPSS software in two categories of descriptive and inferential statistics by using logistic regression model. The results showed that the prevalence of low weight infants was 9.5 percent and 38.7 percent of pregnancies was unwanted. Twenty-nine percent of mothers had marital dissatisfaction. 15/6 percent of pregnancies were below 20 years old and 22 percent was above of 35 years old. 38.9 percent of mothers were exposed to cigarette smoke. The average of weight gain during pregnancies was 9 kilograms. Thirty three percent of mothers had high blood pressure during pregnancy, 26.7 percent had history of abortion and 31.9 percent had history of bleeding. 23/1percent of women was employed during pregnancy, 19.8 percent gave twin birth and 21/1 percent of parents were relative of each other, 29.7 percent of deliveries were done in cesarean way. The results of this study showed that severe marital dissatisfaction, abnormal blood pressure during pregnancy, being employed during pregnancy, weight gain less than 5 Kg during pregnancy, pregnancy below the age of 20 can meaning fully increase the possibility of low birth weight in infant (α=0.05). The results were consisting with the previous findings and indicated that some of the applicable

  4. Mouse Retinal Pigmented Epithelial Cell Lines retain their phenotypic characteristics after transfection with Human Papilloma Virus: A new tool to further the study of RPE biology

    Science.gov (United States)

    Catanuto, Paola; Espinosa-Heidmann, Diego; Pereira-Simon, Simone; Sanchez, Patricia; Salas, Pedro; Hernandez, Eleut; Cousins, Scott W.; Elliot, Sharon J.

    2009-01-01

    Development of immortalized mouse retinal pigmented epithelial cell (RPE) lines that retain many of their in vivo phenotypic characteristics, would aid in studies of ocular diseases including age related macular degeneration (AMD). RPE cells were isolated from 16 month old (estrogen receptor knockout) ERKOα and ERKOβ mice and their C57Bl/6 wild type littermates. RPE65 and cellular retinaldehyde binding protein (CRALBP) expression, in vivo markers of RPE cells, were detected by real-time RT-PCR and western analysis. We confirmed the presence of epithelial cell markers, ZO1, cytokeratin 8 and 18 by immunofluorescence staining. In addition, we confirmed the distribution of actin filaments and the expression of ezrin. To develop cell lines, RPE cells were isolated, propagated and immortalized using human papilloma virus (HPV) 16 (E6/E7). RPE-specific markers and morphology were assessed before and after immortalization. In wildtype littermate controls, there was no evidence of any alterations in the parameters that we examined including MMP-2, TIMP-2, collagen type IV, and estrogen receptor (ER) α and ERβ protein expression and ER copy number ratio. Therefore, immortalized mouse RPE cell lines that retain their in vivo phenotype can be isolated from either pharmacologically or genetically manipulated mice, and may be used to study RPE cell biology. PMID:19013153

  5. Perspective Biological Markers for Autism Spectrum Disorders: Advantages of the Use of Receiver Operating Characteristic Curves in Evaluating Marker Sensitivity and Specificity

    Directory of Open Access Journals (Sweden)

    Provvidenza M. Abruzzo

    2015-01-01

    Full Text Available Autism Spectrum Disorders (ASD are a heterogeneous group of neurodevelopmental disorders. Recognized causes of ASD include genetic factors, metabolic diseases, toxic and environmental factors, and a combination of these. Available tests fail to recognize genetic abnormalities in about 70% of ASD children, where diagnosis is solely based on behavioral signs and symptoms, which are difficult to evaluate in very young children. Although it is advisable that specific psychotherapeutic and pedagogic interventions are initiated as early as possible, early diagnosis is hampered by the lack of nongenetic specific biological markers. In the past ten years, the scientific literature has reported dozens of neurophysiological and biochemical alterations in ASD children; however no real biomarker has emerged. Such literature is here reviewed in the light of Receiver Operating Characteristic (ROC analysis, a very valuable statistical tool, which evaluates the sensitivity and the specificity of biomarkers to be used in diagnostic decision making. We also apply ROC analysis to some of our previously published data and discuss the increased diagnostic value of combining more variables in one ROC curve analysis. We also discuss the use of biomarkers as a tool for advancing our understanding of nonsyndromic ASD.

  6. The effect of organic, biological and chemical fertilizers on yield, essential oil percentage and some agroecological characteristics of summer savory (Satureja hortensis L. under Mashhad conditions

    Directory of Open Access Journals (Sweden)

    E Gholami Sharafkhane

    2016-05-01

    Full Text Available Introduction Savory (Satureja hortensis L. is an annual herbaceous plant that belongs to the Lamiaceae family. Nowadays, the use of biofertilizers is increased in agriculture and their role in increasing the crops production has been demonstrated in many research works (Vessey, 2003; Chen, 2006; Mahfouz & Sharaf- Eldin, 2007. One of the most important visions is sustainable production of enough food plus paying attention to social, economical and environmental aspects. (Gliessman, 1998 stated that the first step to achieve this goal is optimization and improvement of resources use efficiencies. Considering medicinal importance of savory and its role in the food and pharmaceutical industries (Omidbeigi, 2000, beside the limited nutrient resources and need to increase healthy production through using ecological inputs, this study was designed and conducted aimed to evaluate agroecological characteristics of savory as affected by the application of bio fertilizers, chemical and organic fertilizers under Mashhad conditions. Materials and methods In order to study the effects of organic, biological and chemical fertilizers on quantitative and qualitative characteristics of summer savory, a split-plot design based on RCBD with three replications was conducted during the growing season of 2012 at the Agricultural Research Station, College of Agriculture, Ferdowsi University of Mashhad, Iran. Different levels of cattle manure (0 and 25 t.ha-1 were assigned to the main plots and different types of bio fertilizers (Nitroxin, containing Azotobacter sp. and Azospirillum sp., Biophosphor, containing phosphate-solubilizing bacteria (Bacillus sp. and Pseudomonas sp., Biosulfur, containing sulfur-solubilizing bacteria (Thiobacillus ssp., combination of Nitroxin+Biophosphor+ Biosulfur, vermicompost (7 t.ha-1, chemical fertilizers (NPK: 60, 60 and 70 kg.ha-1 and control (no fertilizer were used in the sub- plots. Results and discussion According to the results

  7. Bereaved Employee: Returning to Work

    Science.gov (United States)

    ... Work Working Through Grief About Us The Bereaved Employee: Returning to Work By Helen Fitzgerald, CT After ... One employer called a grief therapist to help employees after a co-worker reported the death of ...

  8. Total anomalous pulmonary venous return

    Science.gov (United States)

    ... pulmonary venous return, x-ray References Fraser CD, Kane LC. Congenital heart disease. In: Townsend CM Jr, ... 62. Review Date 10/17/2017 Updated by: Michael A. Chen, MD, PhD, Associate Professor of Medicine, ...

  9. Return Migration and Working Choices

    OpenAIRE

    TANI, Massimiliano; MAHUTEAU, Stéphane

    2008-01-01

    Collective Action to Support the Reintegration of Return Migrants in their Country of Origin (MIREM) This paper uses the recent survey carried out in the framework of the MIREM project on returnees to Algeria, Morocco and Tunisia and studies the duration of emigration and the labour force status upon returning. The results suggest that age and the year of emigration play a central role in the migration decision, but they do not support the hypothesis that the duration of migration is deter...

  10. Capital Structure and Stock Returns

    OpenAIRE

    Ivo Welch

    2002-01-01

    U.S. corporations do not issue and repurchase debt and equity to counteract the mechanistic effects of stock returns on their debt-equity ratios. Thus over one- to five-year horizons, stock returns can explain about 40 percent of debt ratio dynamics. Although corporate net issuing activity is lively and although it can explain 60 percent of debt ratio dynamics (long-term debt issuing activity being most capital structurerelevant), corporate issuing motives remain largely a mystery. When stock...

  11. [Organising a successful return home].

    Science.gov (United States)

    Mézière, Anthony

    Discharge from hospital is a major component of the quality and efficiency of the healthcare system. The failures of the return home of elderly people testify to the difficulties of applying guidelines in the area of hospital discharge. The action plan decided in the hospital for a successful return home can be jeopardised for personal, relational, functional and structural reasons originating from the different players involved in the hospital discharge. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  12. Overweight and Obesity in Southern Italy: their association with social and life-style characteristics and their effect on levels of biologic markers.

    Science.gov (United States)

    Osella, Alberto R; Díaz, María Del Pilar; Cozzolongo, Rafaelle; Bonfiglio, Caterina; Franco, Isabella; Abrescia, Daniela Isabel; Bianco, Antonella; Giampiero, Elba Silvana; Petruzzi, José; Elsa, Lanzilota; Mario, Correale; Mastrosimni, Anna María; Giocchino, Leandro

    2014-01-01

    In the last decades, overweight and obesity have been transformed from minor public health issues to a major threat to public health affecting the most affluent societies and also the less developed ones. To estimate overweight-obesity prevalence in adults, their association with some social determinants and to assess the effect of these two conditions on levels of biologic and biochemical characteristics, by means of a population-based study. A random sample of the general population of Putignano was drawn. All participants completed a general pre-coded and a Food Frequency questionnaire; anthropometric measures were taken and a venous blood sample was drawn. All subjects underwent liver ultra-sonography. Data description was done by means of tables and then Quantile Regression was performed. Overall prevalence of overweight and obesity were 34.5% and 16.1% respectively. Both overweight and obesity were more frequent among male, married and low socio-economic position subjects. There were increasing frequencies of normal weight with higher levels of education. Overweight and obese subjects had more frequently Nonalcoholic Fatty Liver Disease, Hypertension and altered biochemical markers. Quantile regression showed a statistically significant association of age with overweight and obesity (maximum about 64.8 yo), gender (female) and low levels of education in both overweight and obesity. More than 10 gr/day of wine intake was associated with overweight. The prevention and treatment of overweight/obesity on a population wide basis are needed. Population-based strategies should also improve social and physical environmental contexts for healthful lifestyles.

  13. The effect of lichen-dominated biological soil crusts on growth and physiological characteristics of three plant species in a temperate desert of northwest China.

    Science.gov (United States)

    Zhuang, W W; Serpe, M; Zhang, Y M

    2015-11-01

    Biocrusts (biological soil crusts) cover open spaces between vascular plants in most arid and semi-arid areas. Information on effects of biocrusts on seedling growth is controversial, and there is little information on their effects on plant growth and physiology. We examined impacts of biocrusts on growth and physiological characteristics of three habitat-typical plants, Erodium oxyrhynchum, Alyssum linifolium and Hyalea pulchella, growing in the Gurbantunggut Desert, northwest China. The influence of biocrusts on plant biomass, leaf area, leaf relative water content, photosynthesis, maximum quantum efficiency of PSII (F(v)/F(m)), chlorophyll, osmotic solutes (soluble sugars, protein, proline) and antioxidant enzymes (superoxide dismutase, catalase, peroxidase) was investigated on sites with or without biocrust cover. Biomass, leaf area, leaf water content, photosynthesis, F(v)/F(m) and chlorophyll content in crusted soils were higher than in uncrusted soils during early growth and lower later in the growth period. Soluble sugars, proline and antioxidant enzyme activity were always higher in crusted than in uncrusted soils, while soluble protein content was always lower. These findings indicate that biocrusts have different effects on these three ephemeral species during growth in this desert, primarily via effects on soil moisture, and possibly on soil nutrients. The influence of biocrusts changes during plant development: in early plant growth, biocrusts had either positive or no effect on growth and physiological parameters. However, biocrusts tended to negatively influence plants during later growth. Our results provide insights to explain why previous studies have found different effects of biocrusts on vascular plant growth. © 2015 German Botanical Society and The Royal Botanical Society of the Netherlands.

  14. Geospatial characteristics of Florida's coastal and offshore environments: Distribution of important habitats for coastal and offshore biological resources and offshore sand resources

    Science.gov (United States)

    Demopoulos, Amanda W.J.; Foster, Ann M.; Jones, Michal L.; Gualtieri, Daniel J.

    2011-01-01

    The Geospatial Characteristics GeoPDF of Florida's Coastal and Offshore Environments is a comprehensive collection of geospatial data describing the political boundaries and natural resources of Florida. This interactive map provides spatial information on bathymetry, sand resources, and locations of important habitats (for example, Essential Fish Habitats (EFH), nesting areas, strandings) for marine invertebrates, fish, reptiles, birds, and marine mammals. The map should be useful to coastal resource managers and others interested in marine habitats and submerged obstructions of Florida's coastal region. In particular, as oil and gas explorations continue to expand, the map can be used to explore information regarding sensitive areas and resources in the State of Florida. Users of this geospatial database will have access to synthesized information in a variety of scientific disciplines concerning Florida's coastal zone. This powerful tool provides a one-stop assembly of data that can be tailored to fit the needs of many natural resource managers. The map was originally developed to assist the Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE) and coastal resources managers with planning beach restoration projects. The BOEMRE uses a systematic approach in planning the development of submerged lands of the Continental Shelf seaward of Florida's territorial waters. Such development could affect the environment. BOEMRE is required to ascertain the existing physical, biological, and socioeconomic conditions of the submerged lands and estimate the impact of developing these lands. Data sources included the National Oceanic and Atmospheric Administration, BOEMRE, Florida Department of Environmental Protection, Florida Geographic Data Library, Florida Fish and Wildlife Conservation Commission, Florida Natural Areas Inventory, and the State of Florida, Bureau of Archeological Research. Federal Geographic Data Committee (FGDC) compliant metadata are

  15. Leaving from and returning to nursing practice: contributing factors.

    Science.gov (United States)

    Jamieson, Isabel; Taua, Chris

    2009-07-01

    Many nurses leave nursing and never return. Others return after a period of time. Given the global shortage of nurses a better understanding of these movements is needed. The present study focused on nurses who had been out of nursing for more than five years, and explored factors that influenced their leaving and return to practice. All the nurses who had undertaken a Competency Assessment Programme at a given New Zealand tertiary institution during 2005 were invited to participate. Of the 70 questionnaires mailed out 32 (44.5%) were completed and returned. Quantitative data were analysed using Microsoft Excel, and the qualitative data were coded and analysed by means of content analysis. For each, leaving and returning, three key issues emerged. Nurses left for personal reasons, to seek a career change, or because of poor working conditions. They returned when they had the personal freedom to do so, for fiscal reasons, or because they were motivated by some sense of unfinished business. These findings indicate that it is important for educators involved with Competency Assessment Programmes to collaborate with employers in ensuring that there are opportunities for re-entry to positive work environments, with a degree of flexibility that suits the demographic characteristics of those nurses returning to practice.

  16. Sealed Planetary Return Canister (SPRC), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Sample return missions have primary importance in future planetary missions. A basic requirement is that samples be returned in pristine, uncontaminated condition,...

  17. Multifractal analysis of Moroccan family business stock returns

    Science.gov (United States)

    Lahmiri, Salim

    2017-11-01

    In this paper, long-range temporal correlations at different scales in Moroccan family business stock returns are investigated. For comparison purpose, presence of multifractality is also investigated in Casablanca Stock Exchange (CSE) major indices: MASI which is the all shares index and MADEX which is the index of most liquid shares. It is found that return series of both family business companies and major stock market indices show strong evidence of multifractality. In particular, empirical results reveal that short (long) fluctuations in family business stock returns are less (more) persistent (anti-persistent) than short fluctuations in market indices. In addition, both serial correlation and distribution characteristics significantly influence the strength of the multifractal spectrums of CSE and family business stocks returns. Furthermore, results from multifractal spectrum analysis suggest that family business stocks are less risky. Thus, such differences in price dynamics could be exploited by investors and forecasters in active portfolio management.

  18. Abnormal Returns and Contrarian Strategies

    Directory of Open Access Journals (Sweden)

    Ivana Dall'Agnol

    2003-12-01

    Full Text Available We test the hypothesis that strategies which are long on portfolios of looser stocks and short on portfolios of winner stocks generate abnormal returns in Brazil. This type of evidence for the US stock market was interpreted by The Bondt and Thaler (1985 as reflecting systematic evaluation mistakes caused by investors overreaction to news related to the firm performance. We found evidence of contrarian strategies profitability for horizons from 3 months to 3 years in a sample of stock returns from BOVESPA and SOMA from 1986 to 2000. The strategies are more profitable for shorter horizons. Therefore, there was no trace of the momentum effect found by Jagadeesh and Titman (1993 for the same horizons with US data. There are remaing unexplained positive returns for contrarian strategies after accounting for risk, size, and liquidity. We also found that the strategy profitability is reduced after the Real Plan, which suggests that the Brazilian stock market became more efficient after inflation stabilization.

  19. Dynamic returns of beta arbitrage

    OpenAIRE

    Nascimento, Mafalda

    2017-01-01

    This thesis studies the patterns of the abnormal returns of the beta strategy. The topic can be helpful for professional investors, who intend to achieve a better performance in their portfolios. Following the methodology of Lou, Polk, & Huang (2016), the COBAR measure is computed in order to determine the levels of beta arbitrage in the market in each point in time. It is argued that beta arbitrage activity can have impact on the returns of the beta strategy. In fact, it is demonstrated that...

  20. Sovereign Risk and Currently Returns

    DEFF Research Database (Denmark)

    Della Corte, Pasquale; Sarno, Lucio; Schmeling, Maik

    We empirically investigate the relation between sovereign risk and exchange rates for a broad set of currencies. An increase in the credit default swap (CDS) spread of a country is accompanied by a significant depreciation of the exchange rate. More generally, CDS spread changes have substantial...... explanatory power for currency returns which is largely driven by shocks to global credit risk. Consistent with the notion that sovereign risk is priced, we find that a country's exposure to global credit risk forecasts excess returns to trading exchange rates as well as to trading on the volatility, skewness...

  1. Sovereign Risk and Currency Returns

    DEFF Research Database (Denmark)

    Della Corte, Pasquale; Sarno, Lucio; Schmeling, Maik

    We empirically investigate the relation between sovereign risk and exchange rates for a broad set of currencies. An increase in the credit default swap (CDS) spread of a country is accompanied by a significant depreciation of the exchange rate. More generally, CDS spread changes have substantial...... explanatory power for currency returns which is largely driven by shocks to global credit risk. Consistent with the notion that sovereign risk is priced, we find that a country's exposure to global credit risk forecasts excess returns to trading exchange rates as well as to trading on the volatility, skewness...

  2. The correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions

    Directory of Open Access Journals (Sweden)

    Li Ma

    2017-04-01

    Full Text Available Objective: To study the correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions. Methods: A total of 90 patients with thyroid cancer who accepted surgical treatment in our hospital between March 2015 and September 2016 were selected as the observation group, and 50 patients who received surgery in our hospital during the same period and were with clear pathological diagnosis of thyroid adenoma were selected as the control group. According to the median of ultrasonic elastic strain ratio, the observing group were further divided into high elastic strain ratio group and low elastic strain ratio group (n=45. RT-PCR was used to determine the mRNA expression of proliferation genes, invasion genes and autophagy genes in lesions of all groups of patients. Results: The mean elastic strain ratio of observation group was significantly lower than that of control group. Proliferation gene FOXA1 mRNA expression in lesions of low elastic strain ratio group and high elastic strain ratio group were higher than those of control group while PP4R1 and Smac mRNA expression were lower than those of control group, and as the elastic strain ratio decreased, the FOXA1 mRNA expression increased while PP4R1 and Smac mRNA expression decreased; invasion genes BCORL1, SATB1, Twist1 and CXCR4 mRNA expression in lesions of low elastic strain ratio group and high elastic strain ratio group were higher than those of control group, and as the elastic strain ratio decreased, the BCORL1, SATB1, Twist1 and CXCR4 mRNA expression increased; autophagy genes ARHI, Beclin1, LC3 and PTEN mRNA expression in lesions of low elastic strain ratio group and high elastic strain ratio group were lower than those of control group, and as the elastic strain ratio decreased, the ARHI, Beclin1, LC3 and PTEN mRNA expression decreased. Conclusion: The ultrasonic elastic strain ratio of thyroid cancer is

  3. Effects of exogenous IL-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T cells.

    Science.gov (United States)

    Chen, Yu-Hua; Zhou, Bi-Yun; Wu, Guo-Cai; Liao, De-Quan; Li, Jing; Liang, Si-Si; Wu, Xian-Jin; Xu, Jun-Fa; Chen, Yong-Hua; Di, Xiao-Qing; Lin, Qiong-Yan

    2018-02-14

    This study aims to investigate the effects of exogenous interleukin (IL)-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T (Treg) cells. After isolating the CD4+ CD25+ Treg cells from the peripheral blood, flow cytometry was used to detect the purity of the Treg cells. A549 cells were divided into blank (no transfection), empty plasmid (transfection with pIRES2-EGFP empty plasmid) or IL-37 group (transfection with pIRES2-EGFP-IL-37 plasmid). RT-PCR was used to detect mRNA expression of IL-37 and ELISA to determine IL-37 and MMP-9 expressions. Western blotting was applied to detect the protein expressions of PCNA, Ki-67, Cyclin D1, CDK4, cleaved caspase-3 and cleaved caspase-9. MTT assay, flow cytometry, scratch test and transwell assay were performed to detect cell proliferation, cycle, apoptosis, migration and invasion. Effect of exogenous IL-37 on the chemotaxis of Treg cells was measured through transwell assay. Xenograft models in nude mice were eastablished to detect the impact of IL-37 on A549 cells. The IL-37 group had a higher IL-37 expression, cell apoptosis in the early stage and percentage of cells in the G0/G1 phase than the blank and empty plasmid groups. The IL-37 group had a lower MMP-9 expression, optical density (OD), percentage of cells in the S and G2/M phases, migration, invasion and chemotaxis of CD4+CD25+ Foxp3+ Treg cells. The xenograft volume and weight of nude mice in the IL-37 group were lower than those in the blank and empty plasmid groups. Compared with the blank and empty plasmid groups, the IL-37 group had significantly reduced expression of PCNA, Ki-67, Cyclin D1 and CDK4 but elevated expression of cleaved caspase-3 and cleaved caspase-9. Therefore, exogenous IL-37 inhibits the proliferation, migration and invasion of human lung adenocarcinoma A549 cells as well as the chemotaxis of Treg cells while promoting the apoptosis of A549 cells.

  4. Comet coma sample return instrument

    Science.gov (United States)

    Albee, A. L.; Brownlee, Don E.; Burnett, Donald S.; Tsou, Peter; Uesugi, K. T.

    1994-01-01

    The sample collection technology and instrument concept for the Sample of Comet Coma Earth Return Mission (SOCCER) are described. The scientific goals of this Flyby Sample Return are to return to coma dust and volatile samples from a known comet source, which will permit accurate elemental and isotopic measurements for thousands of individual solid particles and volatiles, detailed analysis of the dust structure, morphology, and mineralogy of the intact samples, and identification of the biogenic elements or compounds in the solid and volatile samples. Having these intact samples, morphologic, petrographic, and phase structural features can be determined. Information on dust particle size, shape, and density can be ascertained by analyzing penetration holes and tracks in the capture medium. Time and spatial data of dust capture will provide understanding of the flux dynamics of the coma and the jets. Additional information will include the identification of cosmic ray tracks in the cometary grains, which can provide a particle's process history and perhaps even the age of the comet. The measurements will be made with the same equipment used for studying micrometeorites for decades past; hence, the results can be directly compared without extrapolation or modification. The data will provide a powerful and direct technique for comparing the cometary samples with all known types of meteorites and interplanetary dust. This sample collection system will provide the first sample return from a specifically identified primitive body and will allow, for the first time, a direct method of matching meteoritic materials captured on Earth with known parent bodies.

  5. Phobos Sample Return: Next Approach

    Science.gov (United States)

    Zelenyi, Lev; Martynov, Maxim; Zakharov, Alexander; Korablev, Oleg; Ivanov, Alexey; Karabadzak, George

    The Martian moons still remain a mystery after numerous studies by Mars orbiting spacecraft. Their study cover three major topics related to (1) Solar system in general (formation and evolution, origin of planetary satellites, origin and evolution of life); (2) small bodies (captured asteroid, or remnants of Mars formation, or reaccreted Mars ejecta); (3) Mars (formation and evolution of Mars; Mars ejecta at the satellites). As reviewed by Galimov [2010] most of the above questions require the sample return from the Martian moon, while some (e.g. the characterization of the organic matter) could be also answered by in situ experiments. There is the possibility to obtain the sample of Mars material by sampling Phobos: following to Chappaz et al. [2012] a 200-g sample could contain 10-7 g of Mars surface material launched during the past 1 mln years, or 5*10-5 g of Mars material launched during the past 10 mln years, or 5*1010 individual particles from Mars, quantities suitable for accurate laboratory analyses. The studies of Phobos have been of high priority in the Russian program on planetary research for many years. Phobos-88 mission consisted of two spacecraft (Phobos-1, Phobos-2) and aimed the approach to Phobos at 50 m and remote studies, and also the release of small landers (long-living stations DAS). This mission implemented the program incompletely. It was returned information about the Martian environment and atmosphere. The next profect Phobos Sample Return (Phobos-Grunt) initially planned in early 2000 has been delayed several times owing to budget difficulties; the spacecraft failed to leave NEO in 2011. The recovery of the science goals of this mission and the delivery of the samples of Phobos to Earth remain of highest priority for Russian scientific community. The next Phobos SR mission named Boomerang was postponed following the ExoMars cooperation, but is considered the next in the line of planetary exploration, suitable for launch around 2022. A

  6. Scaffolded biology.

    Science.gov (United States)

    Minelli, Alessandro

    2016-09-01

    Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as Dawkins' extended phenotype, Turner's extended organism, Oyama's Developmental Systems Theory and Odling-Smee's niche construction theory. Last in time is the description of biological phenomena in terms of hybrids between an organism (scaffolded system) and a living or non-living scaffold, forming unit systems to study processes such as reproduction and development. As scaffold, eventually, we can define any resource used by the biological system, especially in development and reproduction, without incorporating it as happens in the case of resources fueling metabolism. Addressing biological systems as functionally scaffolded systems may help pointing to functional relationships that can impart temporal marking to the developmental process and thus explain its irreversibility; revisiting the boundary between development and metabolism and also regeneration phenomena, by suggesting a conceptual framework within which to investigate phenomena of regular hypermorphic regeneration such as characteristic of deer antlers; fixing a periodization of development in terms of the times at which a scaffolding relationship begins or is terminated; and promoting plant galls to legitimate study objects of developmental biology.

  7. Asymmetry of Returns in the Australian STOCK Market

    Science.gov (United States)

    Gunner, Susan M.; Brooks, Louise; Storer, Robin G.

    We use econophysics techniques to investigate the characteristics of the distribution of returns from the All Ordinaries Index and from optimal portfolios constructed from individual stocks on the Australian Stock Exchange. We find in general that the tails of the distributions are asymmetric and that the negative tail favours a power-law behaviour while the positive tail is more Gaussian.

  8. The Returned Prisoner of War: Factors in Family Reintegration

    Science.gov (United States)

    McCubin, Hamilton I.; And Others

    1975-01-01

    Longitudinal study on 48 families of returned prisoners of war to identify factors to explain degree of reintegration of returnee into his family system. Four sets of data were considered: (1) background characteristics of husband and wife; (2) indices of family preparedness; (3) returnees' prison experiences and their psychiatric status; (4)…

  9. Do Human Arts Really Offer a Lower Return to Education?

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Sørensen, Anders; Schultz, Esben

    of women in their high school. Conditional on high school fixed effects, these  characteristics are unlikely to affect post-university wages and are plausible instruments for the  educational choice. Our 2SLS estimates reveal that the gap in returns to education is negligible, implying that the wage gap...

  10. Effect of host and food availability on the biological characteristics of Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae); Efeito da disponibilidade de hospedeiro e de alimento nas caracteristicas biologicas de Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae)

    Energy Technology Data Exchange (ETDEWEB)

    Pratissoli, Dirceu; Oliveira, Harley N. de; Oliveira, Regiane C. de; Zago, Hugo B. [Universidade Federal do Espirito Santo (UFES), Alegre, ES (Brazil). Centro de Ciencias Agrarias], e-mail: dirceu@npd.ufes.br, e-mail: hnoliveira@insecta.ufv.br; Vieira, Stella M.J. [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Engenharia Agricola

    2004-03-15

    Effect of host and food availability on the biological characteristics of Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae). Biological characteristics of Trichogramma galloi Zucchi, 1988 were evaluated in laboratory where these parasitoids were reared on eggs of Diatraea saccharalis (Lepidoptera, Pyralidae) with or without honey, and exposed to eggs of the host after 0, 6, 12, 24, 36, 48, 60, 72 and 84 hours of emergence. The parasitism rate and viability showed higher for individuals that received food. The sex ratio was not influenced by food. The number of individuals per egg only showed difference for those adults that did not receive food and stayed six hours without the host eggs. Checking the effect of the availability of eggs, only the sex ratio, with or without honey, did not show differences. The results show that T. galloi needs a carbohydrate supply and the time can influence the reproductive capacity. (author)

  11. The impact of leverage on stock returns: an empirical test on the Australian stock market

    OpenAIRE

    Thuy Linh, Doan

    2009-01-01

    Asset pricing model is no longer a new topic to theoretical finance but it still maintains researchers’ interest until now. The role of firm characteristics in explaining the stock returns becomes more and more significant in the empirical studies. The Fama French three factor is the most famous model of testing the firm characteristics: size effect and book to market effect on stock returns. However, this model does not include leverage, one of the most important firm characteristics. Starti...

  12. Ratio K: a New Way of Metering and Evaluating the Risk and Return of Stock Investment

    Institute of Scientific and Technical Information of China (English)

    朱淑珍; 朱静怡

    2003-01-01

    Although widely used, both the Markowitz model and VAR (Value at Risk) model have some limitations in evaluating the risk and return of stock investnent.By the analysis of the conceptions of risk and return,together with the three hypotheses of technological analysis, a novelty model of metering and evaluating the risk and return of stock investnent is established.The major indicator of this model , risk-return ratio K, combines the characteristic indicators of risk and return. Regardless of the form of the risk-return probability density functions, this indicator K can always reflect the risk-return performances of the invested stocks clearly and accurately. How to use the model to make optimum investment and how to make portfolio combined with clustering analysis is also explained.

  13. Financial Integration and Asset Returns

    OpenAIRE

    P Martin; H Rey

    2000-01-01

    The paper investigates the impact of financial integration on asset return, risk diversification and breadth of financial markets. We analyse a three-country macroeconomic model in which (i) the number of financial assets is endogenous; (ii) assets are imperfect substitutes; (iii) cross-border asset trade entails some transaction costs; (iv) the investment technology is indivisible. In such an environment, lower transaction costs between two financial markets translate to higher demand for as...

  14. Returning to work after disability.

    Science.gov (United States)

    Quinn, P Roger

    2002-06-01

    After a workplace injury or disability, there is a period of hardship and adjustment for the injured party as well as all stakeholders in the workers' compensation process. Ultimately, however, return to work is considered. The author reviews this often challenging exercise from the Canadian perspective and stresses the need for timely intervention, honest communication, the coordination of information and resources--and the need for flexibility. A case study on low back pain is included.

  15. CONCEPT OF REENGINEERING AGAIN RETURNS IN ACTUALITY

    Directory of Open Access Journals (Sweden)

    Vasile Ionel POPESCU

    2014-06-01

    Full Text Available Although it was released in the summer of 1990, the concept of reengineering returns in actuality, because in the social and economic conditions that we are experiencing at the moment, to face the increasingly fierce competition more and more companies have to resort to redesign the processes. Throughout this article, after a brief introduction, we will present the factors that contributed to the occurrence of reengineering; trying to highlight what involves this concept, the characteristics of the processes resulted from the reengineering, the importance and methods to prepare a process map, and the method to launch the process redesign. Finally we have issued several opinions and have made a number of recommendations that will lead to achieving a qualitative leap targeted by the companies which resort to reengineering.

  16. Planetary protection considerations for sample-return missions

    Science.gov (United States)

    Rummel, J.

    The analysis on Earth of materials returned from other solar system bodies, and beyond, is likely one of the most effective ways for us to learn about the origins, history, and present state of the universe outside of our home planet. In the past, the Apollo missions were able to return large quantities of material from the Moon, while missions currently flying (Genesis and Stardust) intend to return much smaller quantities of material. Planned and conceptualized future missions (cf., MUSES-C) intend to return a wide variety of samples such as those from a near-Earth asteroid, the surface and atmosphere of Mars , and perhaps once more from the Earth's Moon. In some cases, the bodies targeted for sample return missions may have the capability of harboring indigenous life, while in other cases there is scant possibility of that. Considerations in determining the potential for extraterrestrial contamination from sample return missions have been studied, and include such factors as the availability of liquid water in or on the target body, the availability of m tabolicallye useful energy sources, the likelihood that organic matter was available, and the overall temperature and radiation history of the sampled areas. Also of note is the potential that the natural influx to Earth of that materials in question (e.g., meteorites, etc.) might overwhelm the ability of a targeted sample-return mission to contribute something novel to the Earth's environment. Missions thought to pose a risk of extraterrestrial biological contamination are subject to a containment provision that may be very difficult to implement on a single, moderate-cost mission, but such steps are necessary to protect both our own planet and the health of solar-system exploration missions and the science they can do.

  17. The Effects of Biological Fertilizers, Chemical Fertilizers and Manure Application on Some Qualitative Characteristics of Vicia villosa Roth Forage under Greenhouse Condition

    Directory of Open Access Journals (Sweden)

    R Kamaei

    2017-03-01

    % probability level. Results and Discussion The results showed that in vitro DM digestibility was significantly (P P > 0.5 effect on in vitro organic matter digestibility. The highest and the lowest in vitro OM digestibility values were observed in the Rhizobium + mycorrhiza (77.86% and control (66.48%, respectively. Similarly, the results of previous studies indicated that forage quality significantly improved by inoculation with mycorrhizal fungi fertilizer in comparison with control. There was a significant difference between experimental treatments for percentage of crude protein. All fertilizer treatments increased CP content of forages as compared to that control. The effect of M, M + V and M+NPK treatments on CP was similar and the highest CP was associated to M + These effects of fertilizer treatments may be related to increasing the nitrogen fixation and absorption capacity of plant. Although a negative correlation has been reported between CP and fiber content of forages, the results of our study showed a low non-significant impact of fertilizer treatments on fiber content of forage expressed as NDA and ADF. Moreover, the percentage of Ash for all fertilizer treatments was similar to control, except for Rhizobium + mycorrhiza treatment that showed a higher significant Ash content than control. In this experiment, a significant effect of fertilizer treatments was also observed for dry matter yield of forage. In comparison with control, the combination of mycorrhizal and Rhizobium increased forage dry matter yield by 37.89%. These results are in agreement with. Conclusions The use of biological and organic fertilizers improves availability of nutrients for plant without negative impact on soil and environment. In the present study, we showed an increase in qualitative and quantitative characteristics of Vicia villosa Roth forage by bio-fertilizers application under greenhouse condition. However, a combination of mycorrhiza and Rhizobium had the highest positive impact

  18. Analysis of English language learner performance on the biology Massachusetts comprehensive assessment system: The impact of english proficiency, first language characteristics, and late-entry ELL status

    Science.gov (United States)

    Mitchell, Mary A.

    This study analyzed English language learner (ELL) performance on the June 2012 Biology MCAS, namely on item attributes of domain, cognitive skill, and linguistic complexity. It examined the impact of English proficiency, Latinate first language, first language orthography, and late-entry ELL status. The results indicated that English proficiency was a strong predictor of performance and that ELLs at higher levels of English proficiency overwhelmingly passed. The results further indicated that English proficiency introduced a construct-irrelevant variance on the Biology MCAS and raised validity issues for using this assessment at lower levels of English proficiency. This study also found that ELLs with a Latinate first language consistently had statistically significant lower performance. Late-entry ELL status did not predict Biology MCAS performance.

  19. Nonlinear dynamic interrelationships between real activity and stock returns

    DEFF Research Database (Denmark)

    Lanne, Markku; Nyberg, Henri

    We explore the differences between the causal and noncausal vector autoregressive (VAR) models in capturing the real activity-stock return-relationship. Unlike the conventional linear VAR model, the noncausal VAR model is capable of accommodating various nonlinear characteristics of the data....... In quarterly U.S. data, we find strong evidence in favor of noncausality, and the best causal and noncausal VAR models imply quite different dynamics. In particular, the linear VAR model appears to underestimate the importance of the stock return shock for the real activity, and the real activity shock...

  20. Multivariate return periods of sea storms for coastal erosion risk assessment

    Directory of Open Access Journals (Sweden)

    S. Corbella

    2012-08-01

    Full Text Available The erosion of a beach depends on various storm characteristics. Ideally, the risk associated with a storm would be described by a single multivariate return period that is also representative of the erosion risk, i.e. a 100 yr multivariate storm return period would cause a 100 yr erosion return period. Unfortunately, a specific probability level may be associated with numerous combinations of storm characteristics. These combinations, despite having the same multivariate probability, may cause very different erosion outcomes. This paper explores this ambiguity problem in the context of copula based multivariate return periods and using a case study at Durban on the east coast of South Africa. Simulations were used to correlate multivariate return periods of historical events to return periods of estimated storm induced erosion volumes. In addition, the relationship of the most-likely design event (Salvadori et al., 2011 to coastal erosion was investigated. It was found that the multivariate return periods for wave height and duration had the highest correlation to erosion return periods. The most-likely design event was found to be an inadequate design method in its current form. We explore the inclusion of conditions based on the physical realizability of wave events and the use of multivariate linear regression to relate storm parameters to erosion computed from a process based model. Establishing a link between storm statistics and erosion consequences can resolve the ambiguity between multivariate storm return periods and associated erosion return periods.

  1. Analisis Karakteristik Perusahaan Dan Ekonomi Makro Pada Return Saham Syariah Dan Non Syariah

    Directory of Open Access Journals (Sweden)

    Ardi Hamzah

    2011-10-01

    Full Text Available The objectives of this paper are to determine, to examine, and to test whether firm characteristic and macro economics are the important discriminators for return of syariah and non syariah stock; to determine whether there are any differences in return of some syariah and non syariah stock; to determine and to test whether there is a relationship between return and firm characteristic and macro economis in some syariah and non syariah stock. The total sample is 300 stock that were taken each from 150 for syariah stock and 150 for non syariah stock for period 2005 – 2009. The study also showed that there is a difference in return between syariah and non syariah stock. Finally,with regression analysis indicated that partially price book value, price earnings ratio, and kurs rupiah on dollar significantly effect on return of syariah stock, while for return of non syariah stock only kurs rupiah on dollar that significantly effect on return of non syariah stock. For testing with simultant regression indicate firm characteristic and macro economics significantly effect on return of syariah stock, while at return of non syariah stock not significantly effect.

  2. Puerto Rican Migration: The Return Flow = La Migracion Puertorriquena: El Reflujo a la Isla.

    Science.gov (United States)

    Vivo, Paquita, Comp.

    This is a guide to materials and research on Puerto Ricans who have returned to Puerto Rico after living in the United States. Part 1 is an annotated bibliography of books, journal articles, printed documents, doctoral dissertations, master's theses, journalistic accounts, and unpublished papers on characteristics of Puerto Rican return migrants;…

  3. A new source of mesenchymal stem cells for articular cartilage repair: MSCs derived from mobilized peripheral blood share similar biological characteristics in vitro and chondrogenesis in vivo as MSCs from bone marrow in a rabbit model.

    Science.gov (United States)

    Fu, Wei-Li; Zhou, Chun-Yan; Yu, Jia-Kuo

    2014-03-01

    Bone marrow (BM) has been considered as a major source of mesenchymal stem cells (MSCs), but it has many disadvantages in clinical application. However, MSCs from peripheral blood (PB) could be obtained by a less invasive method and be more beneficial for autologous transplantation than BM MSCs, which makes PB a promising source for articular cartilage repair in clinical use. To assess whether MSCs from mobilized PB of New Zealand White rabbits have similar biological characteristics in vitro and chondrogenesis in vivo as BM MSCs. Controlled laboratory study. A combined method of drug administration containing granulocyte colony stimulating factor (G-CSF) plus CXCR4 antagonist AMD3100 was adopted to mobilize the PB stem cells of adult New Zealand White rabbits in vitro. The isolated cells were identified as MSCs by morphological characteristics, surface markers, and differentiation potentials. A comparison between PB MSCs and BM MSCs was made in terms of biological characteristics in vitro and chondrogenesis in vivo. This issue was investigated from the aspects of morphology, immune phenotype, multiple differentiation capacity, expansion potential, antiapoptotic capacity, and ability to repair cartilage defects in vivo of PB MSCs compared with BM MSCs. Peripheral blood MSCs were successfully mobilized by the method of combined drug administration, then isolated, expanded, and identified in vitro. No significant difference was found concerning the morphology, immune phenotype, and antiapoptotic capacity between PB MSCs and BM MSCs. Significantly, MSCs from both sources compounded with decalcified bone matrix showed the same ability to repair cartilage defects in vivo. For multipluripotency, BM MSCs exhibited a more osteogenic potential and higher proliferation capacity than PB MSCs, whereas PB MSCs possessed a stronger adipogenic and chondrogenic differentiation potential than BM MSCs in vitro. Although there are some differences in the proliferation and

  4. Stochastic arbitrage return and its implication for option pricing

    Science.gov (United States)

    Fedotov, Sergei; Panayides, Stephanos

    2005-01-01

    The purpose of this work is to explore the role that random arbitrage opportunities play in pricing financial derivatives. We use a non-equilibrium model to set up a stochastic portfolio, and for the random arbitrage return, we choose a stationary ergodic random process rapidly varying in time. We exploit the fact that option price and random arbitrage returns change on different time scales which allows us to develop an asymptotic pricing theory involving the central limit theorem for random processes. We restrict ourselves to finding pricing bands for options rather than exact prices. The resulting pricing bands are shown to be independent of the detailed statistical characteristics of the arbitrage return. We find that the volatility “smile” can also be explained in terms of random arbitrage opportunities.

  5. [Discussion on the cultural loss and return of modern acupuncture].

    Science.gov (United States)

    Liu, Bing; Zhao, Jing-sheng; Gao, Shu-zhong

    2009-08-01

    The philosophical ontology analysis was used in this study to explore the self-factors related to the cultural loss of modern acupuncture, and to establish the theoretical constructs and the clinical model for the cultural return. It is indicated that the most important factors related to the cultural loss of modern acupuncture are the separation of technical characteristics and cultural connotations and the diversion of modern techniques away from classical acupuncture. An effective way of the cultural return is to build a harmonious theoretical and clinical model to develop acupuncture. Based on the foundation of acupuncture from its own culture roots, the traditional sense and cultural values should be enhanced to facilitate the cultural return of acupuncture in theory and clinical practice.

  6. Returning to sports after a back injury

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000518.htm Returning to sports after a back injury To use the sharing ... Back pain - returning to sports Which Type of Sport is Best? In deciding when and if to ...

  7. Returns to Tenure or Seniority?

    DEFF Research Database (Denmark)

    Buhai, Ioan Sebastian; Portela, Miguel; Teulings, Coen

      This study documents two empirical regularities, using data for Denmark and Portugal. First, workers who are hired last, are the first to leave the firm (Last In, First Out; LIFO). Second, workers' wages rise with seniority (= a Worker's tenure relative to the tenure of her colleagues). We seek...... at the moment of separation). The LIFO rule provides a stronger bargaining position for senior workers, leading to a return to seniority in wages. Efficiency in hiring requires the workers' .bargaining power to be in line with their share in the cost of specific investment. Then, the LIFO rule is a way...

  8. Reabsorption of returning workers from the Gulf: the Asian experience.

    Science.gov (United States)

    Kazi, S

    1994-01-01

    This study examines trends in return labor migration from the Middle East to South Asia and Southeast Asia. Survey data were used to describe trends in outmigration and socioeconomic characteristics of return migrants and to examine the extent to which return migration is associated with skill level and use of savings and remittances on their return. General trends indicate a decline in outmigration during the late 1980s and early 1990s, after oil prices dropped in 1986. Migrants from Pakistan and Korea declined by half during 1981-85 and by 40% among Indian migrants. The demand for service workers and migrants willing to accept cuts in wages was unaffected. Outmigration from Southeast Asian countries grew in the recent past. These increases were due to the replacement of workers from Jordan and Yemen who were expelled from Saudi Arabia after the Gulf crisis. The shift in occupational demand to service and higher level workers is expected to weaken migration from Pakistan and Bangladesh and to strengthen migration from Sri Lanka and other Southeast Asian countries with a skilled migrant labor force. Outmigration from Southeast Asian countries increased to high-growth destination countries such as Japan, Malaysia, and Singapore. Socioeconomic characteristics of migrants varied by country of origin. For instance, Philippine migrants were better educated. Migrants from Thailand, Bangladesh, and Pakistan were from rural and impoverished areas. Sri Lanka and the Philippines had many women migrants. Return migrants encountered high unemployment. Return migrants to Korea had fewer reemployment problems. Reemployment was associated with local country conditions. Unskilled workers had the highest rates of unemployment. Savings tended to be invested in real estate and housing. Savings and investment from remittance income was high in Sri Lanka, Bangladesh, and Thailand.

  9. Common Factors in International Bond Returns

    NARCIS (Netherlands)

    Driessen, J.J.A.G.; Melenberg, B.; Nijman, T.E.

    2000-01-01

    In this paper we estimate and interpret the factors that jointly determine bond returns of different maturities in the US, Germany and Japan.We analyze both currency-hedged and unhedged bond returns.For currency-hedged bond returns, we find that five factors explain 96.5% of the variation of bond

  10. Foreign currency returns and systematic risks

    NARCIS (Netherlands)

    Galsband, V.; Nitschka, T.

    2015-01-01

    We apply an empirical approximation of the intertemporal capital asset pricing model (ICAPM) to show that cross-sectional dispersion in currency returns can be rationalized by differences in currency excess returns' sensitivities to the market return's cash-flow news component. This finding echoes

  11. Return to work among breast cancer survivors: A literature review.

    Science.gov (United States)

    Sun, Yuanlu; Shigaki, Cheryl L; Armer, Jane M

    2017-03-01

    Breast cancer survivors in their employment years are likely to try to go back to work after the primary treatment. Because the literature on return to work among breast cancer survivors is limited, we have undertaken a review of the literature to summarize what is known, including identifying important contributing variables and outcomes. This knowledge may be used to develop hypotheses and potential interventions to support breast cancer survivors who wish to return to work. We searched the following databases: CINAHL, MEDLINE, SCOUP, and PUBMED, within a 10-year timeframe (2004 to 2014). The majority of reviewed articles (N = 25) focused on three outcomes: return-to-work period, work ability, and work performance. The most frequently studied independent variables were collapsed into the following groups: health and well-being, symptoms and functioning, work demands and work environment, individual characteristics, and societal and cultural factors. Gaps in the literature include evidence of effective interventions to support return to work among breast cancer survivors and research to better understand the roles of government and business-related policy. All the studies reported a reduced work engagement and work ability. Employment status and work performance is associated with a combination of individual factors, work environment, culture, and resources. Significant gaps are apparent in the literature addressing breast cancer survivorship and return to work. This is a complex problem and it will likely require interdisciplinary research teams to develop effective and feasible interventions for this population.

  12. Stock Returns and Risk: Evidence from Quantile

    Directory of Open Access Journals (Sweden)

    Thomas C. Chiang

    2012-12-01

    Full Text Available This paper employs weighted least squares to examine the risk-return relation by applying high-frequency data from four major stock indexes in the US market and finds some evidence in favor of a positive relation between the mean of the excess returns and expected risk. However, by using quantile regressions, we find that the risk-return relation moves from negative to positive as the returns’ quantile increases. A positive risk-return relation is valid only in the upper quantiles. The evidence also suggests that intraday skewness plays a dominant role in explaining the variations of excess returns.

  13. Spatial and temporal variation in evacuee risk perception throughout the evacuation and return-entry process.

    Science.gov (United States)

    Siebeneck, Laura K; Cova, Thomas J

    2012-09-01

    Developing effective evacuation and return-entry plans requires understanding the spatial and temporal dimensions of risk perception experienced by evacuees throughout a disaster event. Using data gathered from the 2008 Cedar Rapids, Iowa Flood, this article explores how risk perception and location influence evacuee behavior during the evacuation and return-entry process. Three themes are discussed: (1) the spatial and temporal characteristics of risk perception throughout the evacuation and return-entry process, (2) the relationship between risk perception and household compliance with return-entry orders, and (3) the role social influences have on the timing of the return by households. The results indicate that geographic location and spatial variation of risk influenced household risk perception and compliance with return-entry plans. In addition, sociodemographic characteristics influenced the timing and characteristics of the return groups. The findings of this study advance knowledge of evacuee behavior throughout a disaster and can inform strategies used by emergency managers throughout the evacuation and return-entry process. © 2012 Society for Risk Analysis.

  14. 76 FR 22611 - Specified Tax Return Preparers Required To File Individual Income Tax Returns Using Magnetic...

    Science.gov (United States)

    2011-04-22

    ... Specified Tax Return Preparers Required To File Individual Income Tax Returns Using Magnetic Media... Register on Wednesday, March 30, 2011 (76 FR 17521) providing guidance to specified tax return preparers who prepare and file individual income tax returns using magnetic media pursuant to section 6011(e)(3...

  15. Biological Agents

    Science.gov (United States)

    ... E-Tools Safety and Health Topics / Biological Agents Biological Agents This page requires that javascript be enabled ... 202) 693-2300 if additional assistance is required. Biological Agents Menu Overview In Focus: Ebola Frederick A. ...

  16. [Effect of mineral N fertilizer reduction and organic fertilizer substitution on soil biological properties and aggregate characteristics in drip-irrigated cotton field.

    Science.gov (United States)

    Li, Rui; Tai, Rui; Wang, Dan; Chu, Gui-Xin

    2017-10-01

    A four year field study was conducted to determine how soil biological properties and soil aggregate stability changed when organic fertilizer and biofertilizer were used to reduce chemical fertilizer application to a drip irrigated cotton field. The study consisted of six fertilization treatments: unfertilized (CK); chemical fertilizer (CF, 300 kg N·hm -2 ; 90 kg P2O5 · hm -2 , 60 kg K2 O·hm -2 ); 80% CF plus 3000 kg·hm -2 organic fertilizer (80%CF+OF); 60% CF plus 6000 kg·hm -2 organic fertilizer (60%CF+OF); 80% CF plus 3000 kg·hm -2 biofertilizer (80%CF+BF); and 60% CF plus 6000 kg·hm -2 biofertilizer (60%CF+BF). The relationships among soil organic C, soil biological properties, and soil aggregate size distribution were determined. The results showed that organic fertilizer and biofertilizer both significantly increased soil enzyme activities. Compared with CF, the biofertilizer treatments increased urease activity by 55.6%-84.0%, alkaline phosphatise activity by 53.1%-74.0%, invertase activity by 15.1%-38.0%, β-glucosidase activity by 38.2%-68.0%, polyphenoloxidase activity by 29.6%-52.0%, and arylsulfatase activity by 35.4%-58.9%. Soil enzyme activity increased as the amount of organic fertilizer and biofertilizer increased (i.e., 60%CF+OF > 80%CF+OF, 60%CF+BF > 80%CF+BF). Soil basal respiration decreased significantly in the order BF > OF > CF > CK. Soil microbial biomass C and N were 22.3% and 43.5% greater, respectively, in 60%CF+BF than in CF. The microbial biomass C:N was significantly lower in 60%CF+BF than in CF. The organic fertilizer and the biofertilizer both improved soil aggregate structure. Soil mass in the >0.25 mm fraction was 7.1% greater in 80%CF+OF and 8.0% greater in (60%CF+OF) than in CF. The geometric mean diameter was 9.2% greater in 80%CF+BF than in 80%CF+OF. Redundancy analysis and cluster analysis both demonstrated that soil aggregate structure and biological activities increased when organic fertilizer and biofertilizer were

  17. RETURNS OF PRIVATE EQUITY COMPARATIVE ANALYSES OF THE RETURNS OF VENTURE CAPITAL AND BUYOUT FUNDS IN EUROPE AND IN THE US

    Directory of Open Access Journals (Sweden)

    Becsky-Nagy Patrícia

    2014-07-01

    Full Text Available This paper focuses on the returns of two segments of Private Equity (PE market in Europe and in the US; Venture Capital (VC and Buyout (BO. Contrary to the publicly traded stocks where information about the trade of securities is public, the measuring of the returns of these asset classes is not unambiguous. The returns of PE investments are considered as confidential information therefore we only have estimations about the real characteristics of the financial performance of the PE industry. Although it is impossible to observe the whole industry it is important to chart its performance because PE plays an essential role in the financing of firms, especially firms at special stages of their lives and the more information the investors and companies have, the more effective PE market can be therefore it can contribute to economic growth, employment, innovation etc. In the literature PE, VC and BO are not distinguished properly and they are often used as synonyms. Despite their similarities, there are significant differences in the features of these types of investments. In this paper the authors present the return characteristics of the PE industry of Europe and the US with regard to the stage-focus of PE funds. The key findings of this paper are that in average the returns of BO funds exceeded the returns of VC funds in the US as well as in Europe. Not just according to the absolute value of the returns, but also according to its risk-return tradeoff BO seems to be a preferable investment. The same statements can be made in case of the European market. The US returns are higher than European VC returns, because compared to the US VC industry the European is undeveloped. On the other hand the gap between the performances of BO funds is not as significant as the difference of VC funds. While in the 90’s US BO funds outperformed the European ones, after the millennia European BO returns were higher. The analysis of returns reveals the

  18. Stock returns and foreign investment in Brazil

    OpenAIRE

    Reis, Luciana; Meurer, Roberto; Da Silva, Sergio

    2008-01-01

    We examine the relationship between stock returns and foreign investment in Brazil, and find that the inflows of foreign investment boosted the returns from 1995 to 2005. There was a strong contemporaneous correlation, although not Granger-causality. Foreign investment along with the exchange rate, the influence of the world stock markets, and country risk can explain 73 percent of the changes that occurred in the stock returns over the period. We also find that positive feedback trading play...

  19. Maximizing ROI (return on information)

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, B.

    2000-05-01

    The role and importance of managing information are discussed, underscoring the importance by quoting from the report of the International Data Corporation, according to which Fortune 500 companies lost $ 12 billion in 1999 due to inefficiencies resulting from intellectual re-work, substandard performance , and inability to find knowledge resources. The report predicts that this figure will rise to $ 31.5 billion by 2003. Key impediments to implementing knowledge management systems are identified as : the cost and human resources requirement of deployment; inflexibility of historical systems to adapt to change; and the difficulty of achieving corporate acceptance of inflexible software products that require changes in 'normal' ways of doing business. The author recommends the use of model, document and rule-independent systems with a document centered interface (DCI), employing rapid application development (RAD) and object technologies and visual model development, which eliminate these problems, making it possible for companies to maximize their return on information (ROI), and achieve substantial savings in implementation costs.

  20. A liquid chromatography-mass spectrometry method based on class characteristic fragmentation pathways to detect the class of indole-derivative synthetic cannabinoids in biological samples.

    Science.gov (United States)

    Mazzarino, Monica; de la Torre, Xavier; Botrè, Francesco

    2014-07-21

    This article describes a liquid chromatographic/tandem mass spectrometric method, based on the use of precursor ion scan as the acquisition mode, specifically developed to detect indole-derived cannabinoids (phenylacetylindoles, naphthoylindoles and benzoylindoles) in biological fluids (saliva, urine and blood). The method is designed to recognize one or more common "structural markers", corresponding to mass spectral fragments originating from the specific portion of the molecular structure that is common to the aminoalkylindole analogues and that is fundamental for their pharmacological classification. As such, the method is also suitable for detecting unknown substances, provided they contain the targeted portion of the molecular structure. The pre-treatment procedure consists in a liquid/liquid extraction step carried out at neutral pH: this is the only pretreatment in the case of analyses carried out in saliva, while it follows an enzymatic hydrolysis procedure in the case of urine samples, or a protein precipitation step in the case of blood samples. The chromatographic separation is achieved using an octadecyl reverse-phase 5 μm fused-core particle column; while the mass spectrometric detection is carried out by a triple-quadrupole instrument in positive electrospray ionization and precursor ion scan as acquisition mode, selecting, as mass spectral fragments, the indole (m/z 144), the carbonylnaphthalenyl (m/z 155) and the naphthalenyl (m/z 127) moieties. Once developed and optimized, the analytical procedure was validated in term of sensitivity (lower limits of detection in the range of 0.1-0.5 ng mL(-1)), specificity (no interference was detected at the retention times of the analytes under investigation), recovery (higher than 65% with a satisfactory repeatability: CV% lower than 10), matrix effect (lower than 30% for all the biological specimens tested), repeatability of the retention times (CV% lower than 0.1), robustness, and carry over (the positive

  1. Risk-return of Belgian SRI funds

    OpenAIRE

    Van Liedekerke, Luc; De Moor, Lieven; Vanwalleghem, Dieter

    2007-01-01

    We analyse the risk-return profile of Belgian SRI funds versus conventional investment funds. We apply a four-factor conditional Carhart model to establish whether there are significant differences in risk-return profile between an SRI portfolio and a conventional portfolio and test for learning effects in SRI funds. We show that there is no difference in risk-return profile between SRI and conventional funds. If return is not the problem, then what is it that limits the development of an SRI...

  2. Money growth and aggregate stock returns

    OpenAIRE

    Böing, Tobias; Stadtmann, Georg

    2016-01-01

    We empirically evaluate the predictive power of money growth measured by M2 for stock returns of the S&P 500 index. We use monthly US data and predict multiperiod returns over 1, 3, and 5 years with long-horizon regressions. In-sample regressions show that money growth is useful for predicting returns. Higher recent money growth has a significantly negative effect on subsequent returns of the S&P 500. An out-of-sample analysis shows that a simple model with money growth as a single predictor ...

  3. Relating Financial and Energy Return on Investment

    Directory of Open Access Journals (Sweden)

    Carey W. King

    2011-10-01

    Full Text Available For many reasons, including environmental impacts and the peaking and depletion of the highest grades of fossil energy, it is very important to have sound methods for the evaluation of energy technologies and the profitability of the businesses that utilize them. In this paper we derive relations among the biophysical characteristic of an energy resource in relation to the businesses and technologies that exploit them. These relations include the energy return on energy investment (EROI, the price of energy, and the profit of an energy business. Our analyses show that EROI and the price of energy are inherently inversely related such that as EROI decreases for depleting fossil fuel production, the corresponding energy prices increase dramatically. Using energy and financial data for the oil and gas production sector, we demonstrate that the equations sufficiently describe the fundamental trends between profit, price, and EROI. For example, in 2002 an EROI of 11:1 for US oil and gas translates to an oil price of 24 $2005/barrel at a typical profit of 10%. This work sets the stage for proper EROI and price comparisons of individual fossil and renewable energy businesses as well as the electricity sector as a whole. Additionally, it presents a framework for incorporating EROI into larger economic systems models.

  4. Evaluation of the Effects of Biological and Chemical Fertilizers on Some Physiological and Growth Characteristics of Fenugreek (Trigonella foenum-graecum

    Directory of Open Access Journals (Sweden)

    Samira Menbari

    2017-12-01

    Full Text Available Nowadays, the use of soil-born microorganisms as biological fertilizers is considered to be a natural and most desirable solution to maintain sustainability of agricultural soil system. Potassium releasing bacteria, nitrogen fixing and phosphorus dissolving bacteria make mentioned elements available to plants. In order to evaluate the effects of bio-fertilizers Potabarvar 2, Sinorhizobium meliloti, as well as urea fertilizer on physiological properties and yield of Fenugreek, an experiment as complete randomized block design was conducted with five treatments and three replications. Treatments included biofertilizer Potabarvar 2, S. meliloti, inoculation with a mixture of Sinorhizobium+Potabarvar 2, positive control (based on soil analysis and negative control (no fertilization and inoculation.The results showed that all morphological traits were significant at 1%. Most physiological traits except for carotenoid were significantly affected by S. meliloti, and a mixture of Sinorhizobium+Potabarvar 2. Seed inoculation with biofertilizer Sinorhizobium meliloti and Potabarvar 2 lead to increase in growth and eventually shoot yield. Separate application of these biofertilizers led to better results than the integrated application. Symbiotic relationship of Sinorhizobium with Fenugreek increased physiological indices data, especially the absorption of nitrogen and phosphorus, as well as the amount of phenolic antioxidant have been significantly affected. In general, application of S. meliloti resulted in better and more effective increase in yield, quality and plant growth than fertilizer Potabarvar 2 and a mixture of Sinorhizobium+Potabarvar 2.

  5. Effects of gelling bath on the physical properties of alginate gel beads and the biological characteristics of entrapped HepG2 cells.

    Science.gov (United States)

    Sun, Dongsheng; Liu, Yang; Wu, Hao; Ren, Ying; Ma, Xiaojun; Wu, Huijian; Sun, Guangwei

    2018-03-01

    Optimizing alginate gel beads is necessary to support the survival, proliferation, and function of entrapped hepatocytes. In this study, gelling bath was modified by decreasing calcium ion concentration and increasing sodium ion concentration. Alginate gel beads (using 36% G sodium alginate) prepared in the modified gelling bath had more homogeneous structure and better mass transfer properties compared with the traditional gelling bath that contains only calcium ions. Moreover, alginate gel beads generated in the modified gelling bath could significantly promote the HepG2 cell proliferation and the growth of cell spheroids, and maintain the albumin secretion ability similar to alginate gel beads prepared in the traditional gelling bath with only calcium ions. The mass transfer properties and cell proliferation were similar in ALG beads with different M/G ratio (36% G and 55% G) generated in the modified gelling bath, whereas they were significantly increased compared with alginate gel beads (55% G) in traditional gelling bath. These results indicated that adjusting the gelling bath was a simple and convenient method to enhance the mass transfer properties of alginate gel beads for 3D hepatocyte culture, which might provide more hepatocytes for the bioartificial liver support system. © 2017 International Union of Biochemistry and Molecular Biology, Inc.

  6. Biodistribution and biological characteristics of p-[(bis-carboxymethyl) aminomethyl carboxyamino] hippuric acid (Pahida) labelled with technetium-99m. Establishment of pharmacokinetics parameters through compartmental model

    International Nuclear Information System (INIS)

    Araujo, E.B. de.

    1990-01-01

    Biologic distribution of p- [(bis-carboxymethylaminomethyl carboxyamino)] hippuric acid (PAHIDA) labeled with sup(99m)Tc in Wistar rats, showed a selective renal uptake among the other organs and tissues. The compound is predominantly eliminated by urinary tract, with small enterohepatic percent of excretion Chromatographic analysis of urine showed the product and possible metabolites. PAHIDA- sup(99m)Tc blood clearance is relatively rapid and a good percent is transported by plasmatic proteins. The percent binding to the erythrocytes is significant after one hour, this is due probably to hydrolysed technetium. The extrapolation of the plasmatic curve denoted the existence of three exponentials, suggesting a model with three compartments: central or intravascular and two peripherics or extravasculars - rapid and slow exchange (retention). Exponential's half life and the transfer constant (k) among the compartments were determined. The compound retention was reaffirmed by whole body determination. The decomposition of the curve in two exponentials allowed to assess the component's half-life. The compartmental model proposed in agreement with the experimental results, showed the complex retention that may be related the binding with the blood components, the possibility of renal metabolization or a structural impediment in the interaction with the tubular cells receptors. (author)

  7. Lead exposures and biological responses in military weapons systems: Aerosol characteristics and acute lead effects among US Army artillerymen: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharyya, M.H.; Stebbings, J.H.; Peterson, D.P.; Johnson, S.A.; Kumar, R.; Goun, B.D.; Janssen, I.; Trier, J.E.

    1993-03-01

    This study was to determine the concentration and chemical nature of lead (Pb) aerosols produced during the firing of artillery and to determine the exposures and biological responses of crew members exposed to lead aerosols during such firing. The concentrations of lead-containing aerosols at crew positions depended on wind conditions, with higher concentrations when firing into a head wind. Aerosol concentrations were highest in the muzzle blast zone. Concentrations of lead in the blood of crew members rose during the first 12 days of exposure to elevated airborne lead concentrations and then leveled off. There was no rapid decrease in blood lead concentrations after completion of firing. Small decreases in hematocrit and small increases in free erythrocyte porphyrin were correlated with increasing exposure to airborne lead. These changes were reversed by seven weeks after firing. Changes in nerve conduction velocity had borderline statistical significance to airborne lead exposure. In measuring nerve conduction velocity, differences in skin temperature must be taken into account.

  8. Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment.

    Science.gov (United States)

    Struff, W G; Sprotte, G

    2007-04-01

    Mammals supply their newborn before birth, at birth or shortly after birth with antibodies, immunocytes and humoral constituents. This "borrowed immunity" is a form of passive immunization to protect the newborn against environmental pathogens until it establishes its own pathogen recognition and disposal systems. In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-class in particular, are acquired from the mother by placental transport in the weeks prior to parturition. It has long been known that the consumption of bovine colostrum by humans has therapeutic effects e.g. in gastrointestinal infections, but only since the second half of the last century has it been possible to prepare stable, standardized preparations of colostrum. These biologics are administered to patients in combination with standard therapies as so-called balanced supportive diets. Investigations with standardized colostrum preparations in animal models of human disease and estimates of bovine IgG activity in the human GI-tract, described in this review, have provided preclinical data supporting the use of bovine colostrum in human diseases. On the other hand, the number of bovine colostrum products with a sufficiently large and reliable database is limited and the precise nature of the therapeutic targets is still being evaluated.

  9. Maximizing your return on people.

    Science.gov (United States)

    Bassi, Laurie; McMurrer, Daniel

    2007-03-01

    Though most traditional HR performance metrics don't predict organizational performance, alternatives simply have not existed--until now. During the past ten years, researchers Laurie Bassi and Daniel McMurrer have worked to develop a system that allows executives to assess human capital management (HCM) and to use those metrics both to predict organizational performance and to guide organizations' investments in people. The new framework is based on a core set of HCM drivers that fall into five major categories: leadership practices, employee engagement, knowledge accessibility, workforce optimization, and organizational learning capacity. By employing rigorously designed surveys to score a company on the range of HCM practices across the five categories, it's possible to benchmark organizational HCM capabilities, identify HCM strengths and weaknesses, and link improvements or back-sliding in specific HCM practices with improvements or shortcomings in organizational performance. The process requires determining a "maturity" score for each practice, based on a scale of 1 (low) to 5 (high). Over time, evolving maturity scores from multiple surveys can reveal progress in each of the HCM practices and help a company decide where to focus improvement efforts that will have a direct impact on performance. The authors draw from their work with American Standard, South Carolina's Beaufort County School District, and a bevy of financial firms to show how improving HCM scores led to increased sales, safety, academic test scores, and stock returns. Bassi and McMurrer urge HR departments to move beyond the usual metrics and begin using HCM measurement tools to gauge how well people are managed and developed throughout the organization. In this new role, according to the authors, HR can take on strategic responsibility and ensure that superior human capital management becomes central to the organization's culture.

  10. Biological and genetic characteristics of Glyptotendipes tokunagai (Diptera: Chironomidae) on the basis of successive rearing of forty-two generations over seven years under laboratory conditions.

    Science.gov (United States)

    Baek, Min Jeong; Yoon, Tae Joong; Kang, Hyo Jeong; Bae, Yeon Jae

    2014-10-01

    Members of the nonbiting midge family Chironomidae have been used worldwide as water-quality indicators or toxicity test organisms. The purpose of this study was to establish the chironomid Glyptotendipes tokunagai Sasa as a new test species by conducting successive rearing under laboratory conditions. We monitored biological and genetic aspects of >42 successive generations over 7 yr, and also compared the development of the 39th generation with the fourth generation under five constant temperatures of 15, 20, 25, 30, and 35°C. We observed that the number of eggs in an egg mass and the adult body sizes decreased rapidly in the early generations, and thereafter tended to stabilize from the fifth generation to the 42nd generation. In all generations, the mean hatching rate was >75%. Males were predominant in the early generations, but the sex ratio increased to 0.5 (ranged 0.24-0.61) in later generations. The genetic divergence of the reared generations, analyzed by using the mitochondrial cytochrome c oxidase subunit I gene, decreased from 0.0049 to 0.0004 as the generations progressed. In comparison with the fourth generation, the mortality and developmental time of the 39th generation were generally greater, and the adult body sizes were generally smaller. The estimated low developmental threshold temperatures of eggs, male larvae to male adults, and female larvae to female adults were 9.6, 11.3, and 9.7°C, respectively. The optimal rearing temperature was determined to be 25°C. This is the first record of domesticated rearing of a wild chironomid species under laboratory conditions for >7 yr.

  11. Biological characteristics of Anticarsia gemmatalis (Lepidoptera: Noctuidae) for three consecutive generations under different temperatures: understanding the possible impact of global warming on a soybean pest.

    Science.gov (United States)

    da Silva, D M; Hoffmann-Campo, C B; de Freitas Bueno, A; de Freitas Bueno, R C O; de Oliveira, M C N; Moscardi, F

    2012-06-01

    Climate changes can affect the distribution and intensity of insect infestations through direct effects on their life cycles. Experiments were carried out during three consecutive generations to evaluate the effect of different temperatures (25°C, 28°C, 31°C, 34°C and 37±1°C) on biological traits of the velvetbean caterpillar Anticarsia gemmatalis Hübner, 1818 (Lepidoptera: Noctuidae). The insects were fed on artificial diet and reared in environmental chambers set at 14 h photophase. The developmental cycle slowed with the increase in the temperature, within the 25°C to 34°C range. Male and female longevities were reduced with an increase in temperature from 25°C to 28°C. Egg viability was highest at 25°C, and the sex ratio was not influenced by temperature, in the three generations. There was no interactive effect between development time and temperature on pupal weight. The results suggested that the increase in the temperature negatively impacted A. gemmatalis development inside the studied temperature range, indicating a possible future reduction of its occurrence on soybean crops, as a consequence of global warming, mainly considering its impact on tropical countries where this plant is cropped. A. gemmatalis was not able to adapt to higher temperatures in a three-generation interval for the studied temperature range. However, a gradual increase and a longer adaptation period may favor insect selection and consequently adaptation, and must be considered in future studies in this area. Moreover, it is important to consider that global warming might turn cold areas more suitable to A. gemmatalis outbreaks. Therefore, more than a future reduction of A. gemmatalis occurrence due to global warming, we might expect changes regarding its area of occurrence on a global perspective.

  12. Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota-design, methods, and data, 2009

    Science.gov (United States)

    Lee, Kathy E.; Langer, Susan K.; Barber, Larry B.; Writer, Jeff H.; Ferrey, Mark L.; Schoenfuss, Heiko L.; Furlong, Edward T.; Foreman, William T.; Gray, James L.; ReVello, Rhiannon C.; Martinovic, Dalma; Woodruff, Olivia R.; Keefe, Steffanie H.; Brown, Greg K.; Taylor, Howard E.; Ferrer, Imma; Thurman, E. Michael

    2011-01-01

    This report presents the study design, environmental data, and quality-assurance data for an integrated chemical and biological study of selected streams or lakes that receive wastewater-treatment plant effluent in Minnesota. This study was a cooperative effort of the U.S. Geological Survey, the Minnesota Pollution Control Agency, St. Cloud State University, the University of St. Thomas, and the University of Colorado. The objective of the study was to identify distribution patterns of endocrine active chemicals, pharmaceuticals, and other organic and inorganic chemicals of concern indicative of wastewater effluent, and to identify biological characteristics of estrogenicity and fish responses in the same streams. The U.S. Geological Survey collected and analyzed water, bed-sediment, and quality-assurance samples, and measured or recorded streamflow once at each sampling location from September through November 2009. Sampling locations included surface water and wastewater-treatment plant effluent. Twenty-five wastewater-treatment plants were selected to include continuous flow and periodic release facilities with differing processing steps (activated sludge or trickling filters) and plant design flows ranging from 0.002 to 10.9 cubic meters per second (0.04 to 251 million gallons per day) throughout Minnesota in varying land-use settings. Water samples were collected from the treated effluent of the 25 wastewater-treatment plants and at one point upstream from and one point downstream from wastewater-treatment plant effluent discharges. Bed-sediment samples also were collected at each of the stream or lake locations. Water samples were analyzed for major ions, nutrients, trace elements, pharmaceuticals, phytoestrogens and pharmaceuticals, alkylphenols and other neutral organic chemicals, carboxylic acids, and steroidal hormones. A subset (25 samples) of the bed-sediment samples were analyzed for carbon, wastewater-indicator chemicals, and steroidal hormones; the

  13. Return-to-Work Program for Injured Workers: Factors of Successful Return to Employment.

    Science.gov (United States)

    Awang, Halimah; Shahabudin, Sharifah Muhairah; Mansor, Norma

    2016-11-01

    This study examined the factors of successful return to employment among participants in the return to work program (RTW) following work-related injury. Data were obtained from the Social Security Organization database containing 9850 injured workers who underwent RTW in 2010 to 2013. About 65% had successfully returned to employment. Significant factors of successful return include gender, employer interest, motivation, age, intervention duration, and type of injury. Male and motivated employees were more likely to return to employment compared with female and unmotivated employees, respectively. Participants from interested employers were 23.22 times more likely to return to work than those from uninterested employers, whereas participants whose intervention period exceeded 5 months were 41% less likely to return to work compared with those whose intervention period was within 3 months. Appropriate strategy and enhanced collaboration between the stakeholders would improve the proportion of successful return to employment. © 2016 APJPH.

  14. A core handling device for the Mars Sample Return Mission

    Science.gov (United States)

    Gwynne, Owen

    1989-01-01

    A core handling device for use on Mars is being designed. To provide a context for the design study, it was assumed that a Mars Rover/Sample Return (MRSR) Mission would have the following characteristics: a year or more in length; visits by the rover to 50 or more sites; 100 or more meter-long cores being drilled by the rover; and the capability of returning about 5 kg of Mars regolith to Earth. These characteristics lead to the belief that in order to bring back a variegated set of samples that can address the range of scientific objetives for a MRSR mission to Mars there needs to be considerable analysis done on board the rover. Furthermore, the discrepancy between the amount of sample gathered and the amount to be returned suggests that there needs to be some method of choosing the optimal set of samples. This type of analysis will require pristine material-unaltered by the drilling process. Since the core drill thermally and mechanically alters the outer diameter (about 10 pct) of the core sample, this outer area cannot be used. The primary function of the core handling device is to extract subsamples from the core and to position these subsamples, and the core itself if needed, with respect to the various analytical instruments that can be used to perform these analyses.

  15. Return on Investment from Biochar Application

    Science.gov (United States)

    Current literature has yet to fully address the cost of biochar application or the return on investment to the grower. The objectives were to identify possible on-farm spreader equipment, spreader capacity, application expenses, and rate of return needed for growers to apply biochar economically. Bi...

  16. Aggregate Unemployment Decreases Individual Returns to Education

    Science.gov (United States)

    Ammermueller, Andreas; Kuckulenz, Anja; Zwick, Thomas

    2009-01-01

    Aggregate unemployment may affect individual returns to education through qualification-specific responses in participation and wage bargaining. This paper shows that an increase in regional unemployment by 1% decreases returns to education by 0.005 percentage points. This implies that higher skilled employees are better sheltered from labour…

  17. A Perishable Inventory Model with Return

    Science.gov (United States)

    Setiawan, S. W.; Lesmono, D.; Limansyah, T.

    2018-04-01

    In this paper, we develop a mathematical model for a perishable inventory with return by assuming deterministic demand and inventory dependent demand. By inventory dependent demand, it means that demand at certain time depends on the available inventory at that time with certain rate. In dealing with perishable items, we should consider deteriorating rate factor that corresponds to the decreasing quality of goods. There are also costs involved in this model such as purchasing, ordering, holding, shortage (backordering) and returning costs. These costs compose the total costs in the model that we want to minimize. In the model we seek for the optimal return time and order quantity. We assume that after some period of time, called return time, perishable items can be returned to the supplier at some returning costs. The supplier will then replace them in the next delivery. Some numerical experiments are given to illustrate our model and sensitivity analysis is performed as well. We found that as the deteriorating rate increases, returning time becomes shorter, the optimal order quantity and total cost increases. When considering the inventory-dependent demand factor, we found that as this factor increases, assuming a certain deteriorating rate, returning time becomes shorter, optimal order quantity becomes larger and the total cost increases.

  18. Slow return of displaced Southern Sudanese

    Directory of Open Access Journals (Sweden)

    Tim Morris

    2007-07-01

    Full Text Available The pace of repatriation of Sudanese refugees and return of IDP s to South Sudan has picked up but expectations at the time of the signing of the Comprehensive Peace Agreement (CPA CPA in January 2005 have yet to be realised. With all eyes on Darfur, assistance to sustain returns to South Sudan remains inadequate.

  19. Managing Returns in a Catalog Distribution Center

    Science.gov (United States)

    Gates, Joyce; Stuart, Julie Ann; Bonawi-tan, Winston; Loehr, Sarah

    2004-01-01

    The research team of the Purdue University in the United States developed an algorithm that considers several different factors, in addition to cost, to help catalog distribution centers process their returns more efficiently. A case study to teach the students important concepts involved in developing a solution to the returns disposition problem…

  20. 27 CFR 41.112 - Tax return.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Tax return. 41.112 Section 41.112 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF... States Deferred Payment of Tax in Puerto Rico on Tobacco Products § 41.112 Tax return. The internal...

  1. Economic and accounting rates of return

    NARCIS (Netherlands)

    Feenstra, D.W.; Wang, H.

    2000-01-01

    The rate of return on invested capital is a central concept in financial analysis. The purpose of calculating the rate of return on investment in general is to measure the financial performance, to assess the desirability of a project and to make decisions on the valuation of firms. Financial

  2. The Returns to Quality in Graduate Education

    Science.gov (United States)

    Stevenson, Adam

    2016-01-01

    This paper estimates the monetary return to quality in US graduate education, controlling for cognitive ability and self-selection across award level, program quality, and field-of-study. In most program types, I cannot reject the hypothesis of no returns to either degree completion or program quality. Important exceptions include master's…

  3. Predictability of Returns and Cash Flows

    OpenAIRE

    Ralph S.J. Koijen; Stijn Van Nieuwerburgh

    2010-01-01

    We review the literature on return and cash-flow growth predictability from the perspective of the present-value identity. We focus predominantly on recent work. Our emphasis is on U.S. aggregate stock return predictability, but we also discuss evidence from other asset classes and countries.

  4. Legal institutions, strategic default, and stock returns

    NARCIS (Netherlands)

    Favara, G.; Schroth, E.; Valta, P.

    2008-01-01

    This paper studies the impact of legal institutions on stock returns. More specifically, we examine how differences in debt enforcement and creditor protection around the world affect stock returns of individual firms. We hypothesize that if legal institutions prevent shareholders from engaging in

  5. Return to Experience and Initial Wage Level

    DEFF Research Database (Denmark)

    Sørensen, Kenneth Lykke; Vejlin, Rune Majlund

    This paper estimates the relationship between initial wage and return to experience. We use a Mincer-like wage model to nonparametrically estimate this relationship allowing for an unobservable individual permanent effect in wages and unobservable individual return to experience. The relationship...

  6. Return to experience and initial wage level

    DEFF Research Database (Denmark)

    Sørensen, K.L.; Vejlin, R.

    2014-01-01

    This paper estimates the relationship between initial wage and return to experience. We use a Mincer-like wage model to non-parametrically estimate this relationship allowing for an unobservable individual permanent effect in wages and unobservable individual return to experience. The relationshi...

  7. Returnable containers: an example of reverse logistics

    NARCIS (Netherlands)

    L.G. Kroon (Leo); G.M.C. Vrijens

    1996-01-01

    textabstractConsiders the application of returnable containers as an example of reverse logistics. A returnable container is a type of secondary packaging that can be used several times in the same form, in contrast with traditional cardboard boxes. For this equipment to be used, a system for the

  8. Return to the workforce following infective endocarditis

    DEFF Research Database (Denmark)

    Butt, Jawad H.; Kragholm, Kristian; Dalager-Pedersen, Michael

    2018-01-01

    Background The ability to return to work after infective endocarditis (IE) holds important socioeconomic consequences for both patients and society, yet data on this issue are sparse. We examined return to the workforce and associated factors in IE patients of working age. Methods Using Danish...

  9. Husbands' return migration and wives' occupational choices

    NARCIS (Netherlands)

    Mahe, Clotilde

    2017-01-01

    Exploiting the documented effect of migration on occupational choice upon return to their origin country with data from Egypt, we establish a link between return migration of men and their wives' time use through within-couple occupational interdependence. Seemingly Unrelated Regression model

  10. Parasitic diseases in the returning traveller

    African Journals Online (AJOL)

    2009-06-11

    Jun 11, 2009 ... exception is infection with schistosomiasis after leisure activities in infested freshwater. (the water sports enthusiast returning from a sojourn on Lake Malawi .... are harbouring a 'blind passenger' from abroad. However, long-term travellers, both private or business, should be screened on return. A thorough ...

  11. CHARACTERISTICS AND TROUBLES OF JOHN SEARLE'S BIOLOGICAL NATURALISM CARACTERÍSTICAS E DIFICULDADES DO NATURALISMO BIOLÓGICO DE JOHN SEARLE

    Directory of Open Access Journals (Sweden)

    Tárik de Athayde Prata

    2010-10-01

    Full Text Available The paper aims at giving a general exposition of John Searle’s solution of the mind-body problem – biological naturalism – and examines its fundamental theses, and some of its consequences. The exam of such theses – which delineates the characteristics of Searle's theory – shows that the theory has three main difficulties, since it   holds some assertions which at first sight seem to be incompatible.

  1. A numerical study on bow shocks around the lightning return stroke channel

    International Nuclear Information System (INIS)

    Chen, Qiang; Chen, Bin; Yi, Yun; Chen, P. F.; Mao, Yunfei; Xiong, Run

    2015-01-01

    Bow shock structures are important to various hydrodynamics and magnetohydrodynamics (MHD) phenomena in geophysics and astrophysics. The formation and propagation of bow shocks around the lightning return stroke channel are investigated based on the self-similar motion theory and simulated with a two-dimensional Eulerian finite volume resistive radiation MHD code. In this framework, as verification of theoretical models, the evolving structures of many quantities, such as the plasma density, temperature, pressure, shock velocity, and magnetic field, can be obtained, which present all the characteristics of bow shocks in the lightning return stroke processes. The evolution characteristics and the configuration of the curved return stroke channels, e.g., the non-ideal effects and the scaling laws, are discussed in detail. The results may have applications for some observed features of the return stroke channels and other phenomena in the lightning discharge plasmas

  2. Miners' return to work following injuries in coal mines.

    Science.gov (United States)

    Bhattacherjee, Ashis; Kunar, Bijay Mihir

    2016-12-22

    The occupational injuries in mines are common and result in severe socio-economical consequences. Earlier studies have revealed the role of multiple factors such as demographic factors, behavioral factors, health-related factors, working environment, and working conditions for mine injuries. However, there is a dearth of information about the role of some of these factors in delayed return to work (RTW) following a miner's injury. These factors may likely include personal characteristics of injured persons and his or her family, the injured person's social and economic status, and job characteristics. This study was conducted to assess the role of some of these factors for the return to work following coal miners' injuries. A study was conducted for 109 injured workers from an underground coal mine in the years 2000-2009. A questionnaire, which was completed by the personnel interviews, included among others age, height, weight, seniority, alcohol consumption, sleeping duration, presence of diseases, job stress, job satisfaction, and injury type. The data was analyzed using the Kaplan-Meier estimates and the Cox proportional hazard model. According to Kaplan-Meier estimate it was revealed that a lower number of dependents, longer sleep duration, no job stress, no disease, no alcohol addiction, and higher monthly income have a great impact on early return to work after injury. The Cox regression analysis revealed that the significant risk factors which influenced miners' return to work included presence of disease, job satisfaction and injury type. The mine management should pay attention to significant risk factors for injuries in order to develop effective preventive measures. Med Pr 2016;67(6):729-742. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  3. Miners’ return to work following injuries in coal mines

    Directory of Open Access Journals (Sweden)

    Ashis Bhattacherjee

    2016-12-01

    Full Text Available Background: The occupational injuries in mines are common and result in severe socio-economical consequences. Earlier studies have revealed the role of multiple factors such as demographic factors, behavioral factors, health-related factors, working environment, and working conditions for mine injuries. However, there is a dearth of information about the role of some of these factors in delayed return to work (RTW following a miner’s injury. These factors may likely include personal characteristics of injured persons and his or her family, the injured person’s social and economic status, and job characteristics. This study was conducted to assess the role of some of these factors for the return to work following coal miners’ injuries. Material and Methods: A study was conducted for 109 injured workers from an underground coal mine in the years 2000–2009. A questionnaire, which was completed by the personnel interviews, included among others age, height, weight, seniority, alcohol consumption, sleeping duration, presence of diseases, job stress, job satisfaction, and injury type. The data was analyzed using the Kaplan-Meier estimates and the Cox proportional hazard model. Results: According to Kaplan-Meier estimate it was revealed that a lower number of dependents, longer sleep duration, no job stress, no disease, no alcohol addiction, and higher monthly income have a great impact on early return to work after injury. The Cox regression analysis revealed that the significant risk factors which influenced miners’ return to work included presence of disease, job satisfaction and injury type. Conclusions: The mine management should pay attention to significant risk factors for injuries in order to develop effective preventive measures. Med Pr 2016;67(6:729–742

  4. Modern Biology

    OpenAIRE

    ALEKSIC, Branko

    2014-01-01

    The purpose of this course is to learn the philosophy, principles, and techniques of modern biology. The course is particularly designed for those who have not learned biology previously or whose major is other than biology, and who may think that they do not need to know any biology at all. The topics are covered in a rather general, overview manner, but certain level of diligence in grasping concepts and memorizing the terminology is expected.

  5. Return to sports after shoulder arthroplasty

    Science.gov (United States)

    Johnson, Christine C; Johnson, Daniel J; Liu, Joseph N; Dines, Joshua S; Dines, David M; Gulotta, Lawrence V; Garcia, Grant H

    2016-01-01

    Many patients prioritize the ability to return to sports following shoulder replacement surgeries, including total shoulder arthroplasty (TSA), reverse total shoulder arthroplasty (RTSA), and hemiarthroplasty (HA). While activity levels after hip and knee replacements have been well-established in the literature, studies on this topic in the field of shoulder arthroplasty are relatively limited. A review of the literature regarding athletic activity after shoulder arthroplasty was performed using the PubMed database. All studies relevant to shoulder arthroplasty and return to sport were included. The majority of patients returned to their prior level of activity within six months following TSA, RTSA, and shoulder HA. Noncontact, low demand activities are permitted by most surgeons postoperatively and generally have higher return rates than contact sports or high-demand activities. In some series, patients reported an improvement in their ability to participate in sports following the arthroplasty procedure. The rates of return to sports following TSA (75%-100%) are slightly higher than those reported for HA (67%-76%) and RTSA (75%-85%). Patients undergoing TSA, RTSA, and shoulder HA should be counseled that there is a high probability that they will be able to return to their preoperative activity level within six months postoperatively. TSA has been associated with higher rates of return to sports than RTSA and HA, although this may reflect differences in patient population or surgical indication. PMID:27672564

  6. Utility allowed returns and market extremes

    International Nuclear Information System (INIS)

    Murry, D.A.; Nan, G.D.; Harrington, B.M.

    1993-01-01

    In recent years interest rates have fluctuated from exceptionally high levels in the early 1980s to their current levels, the lowest in two decades. Observers and analysts generally have assumed that allowed returns by regulatory commissions follow the movement of interest rates; indeed some analysts use a risk premium method to estimate the cost of common equity, assuming a constant and linear relationship between interest rates and the cost of common equity. That suggests we could expect a relatively stable relationship between interest rates and allowed returns, as well. However, a simple comparison of allowed returns and interest rates shows that this is not the case in recent years. The relationship between market interest rates and the returns allowed by commissions varies and is obviously a great deal more complicated. Empirically, there appears to be only a narrow range where market interest rates significantly affect the allowed returns on common stock set by state commissions, at least for electric and combination utilities. If rates are at historically low levels, allowed returns based largely on market rates will hasten subsequent rate filings, and commissions appear to look beyond the low rate levels. Conversely, it appears that regulators do not let historically high market rates determine allowed returns either. At either high or low interest levels, caution seems to be the policy

  7. Effectiveness of Securities with Fuzzy Probabilistic Return

    Directory of Open Access Journals (Sweden)

    Krzysztof Piasecki

    2011-01-01

    Full Text Available The generalized fuzzy present value of a security is defined here as fuzzy valued utility of cash flow. The generalized fuzzy present value cannot depend on the value of future cash flow. There exists such a generalized fuzzy present value which is not a fuzzy present value in the sense given by some authors. If the present value is a fuzzy number and the future value is a random one, then the return rate is given as a probabilistic fuzzy subset on a real line. This kind of return rate is called a fuzzy probabilistic return. The main goal of this paper is to derive the family of effective securities with fuzzy probabilistic return. Achieving this goal requires the study of the basic parameters characterizing fuzzy probabilistic return. Therefore, fuzzy expected value and variance are determined for this case of return. These results are a starting point for constructing a three-dimensional image. The set of effective securities is introduced as the Pareto optimal set determined by the maximization of the expected return rate and minimization of the variance. Finally, the set of effective securities is distinguished as a fuzzy set. These results are obtained without the assumption that the distribution of future values is Gaussian. (original abstract

  8. Stock return distribution in the BRICS

    Directory of Open Access Journals (Sweden)

    George Adu

    2015-12-01

    Full Text Available Stock returns in emerging market economies exhibit patterns that are distinctively different from developed countries: returns are noted to be highly volatile and autocorrelated, and long horizon returns are predictable. While these stylized facts are well established, the assumption underlying the distribution of returns is less understood. In particular, the empirical literature continues to rely on the normality assumption as a starting point, and most asset pricing models tend to overstretch this point. This paper questions the rationale behind this supposition and proceeds to test more formally for normality using multivariate joint test for skewness and kurtosis. Additionally, the paper extends the literature by examining a number of empirical regularities for Brazil, Russia, India, China and South Africa (the BRICS for short. Our main findings are that the distribution of stock returns for the BRICS exhibits peakedness with fatter and longer tails, and this is invariant to both the unit of measurement and the time horizon of returns. Volatility clustering is prevalent in all markets, and this decays exponentially for all but Brazil. The relationship between risk and return is found to be significant and risk premiums are prevalent in our sample.

  9. Effect of biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging, on ultrasound-guided high-intensity focused ultrasound ablation.

    Science.gov (United States)

    Zhao, Wen-Peng; Chen, Jin-Yun; Chen, Wen-Zhi

    2015-02-01

    The aims of this study were to assess the effects of the biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging (MRI), on ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Thirty-five patients with 39 symptomatic uterine fibroids who underwent myomectomy or hysterectomy were enrolled. Before surgery, the uterine fibroids were subdivided into hypo-intense, iso-intense, heterogeneous hyper-intense and homogeneous hyper-intense categories based on signal intensity on T2-weighted MRI. Tissue density and moisture content were determined in post-operative samples and normal uterine tissue, the isolated uterine fibroids were subjected to USgHIFU, and the extent of ablation was measured using triphenyltetrazolium chloride. Hematoxylin and eosin staining and sirius red staining were undertaken to investigate the organizational structure of the uterine fibroids. Estrogen and progesterone receptor expression was assayed via immunohistochemical staining. The mean diameter of uterine fibroids was 6.9 ± 2.8 cm. For all uterine fibroids, the average density and moisture content were 10.7 ± 0.7 mg/mL and 75.7 ± 2.4%, respectively; and for the homogeneous hyper-intense fibroids, 10.3 ± 0.5 mg/mL and 76.6 ± 2.3%. The latter subgroup had lower density and higher moisture content compared with the other subgroups. After USgHIFU treatment, the extent of ablation of the hyper-intense fibroids was 102.7 ± 42.1 mm(2), which was significantly less than those of the hypo-intense and heterogeneous hyper-intense fibroids. Hematoxylin and eosin staining and sirius red staining revealed that the homogeneous hyper-intense fibroids had sparse collagen fibers and abundant cells. Immunohistochemistry results revealed that estrogen and progesterone receptors were highly expressed in the homogeneous hyper-intense fibroids. This study revealed that lower density, higher moisture content, sparse collagen

  10. Omega-optimized portfolios: applying stochastic dominance criterion for the selection of the threshold return

    Directory of Open Access Journals (Sweden)

    Renaldas Vilkancas

    2016-05-01

    Full Text Available Purpose of the article: While using asymmetric risk-return measures an important role is played by selection of the investor‘s required or threshold rate of return. The scientific literature usually states that every investor should define this rate according to their degree of risk aversion. In this paper, it is attempted to look at the problem from a different perspective – empirical research is aimed at determining the influence of the threshold rate of return on the portfolio characteristics. Methodology/methods: In order to determine the threshold rate of return a stochastic dominance criterion was used. The results are verified using the commonly applied method of backtesting. Scientific aim: The aim of this paper is to propose a method allowing selecting the threshold rate of return reliably and objectively. Findings: Empirical research confirms that stochastic dominance criteria can be successfully applied to determine the rate of return preferred by the investor. Conclusions: A risk-free investment rate or simply a zero rate of return commonly used in practice is often justified neither by theoretical nor empirical studies. This work suggests determining the threshold rate of return by applying the stochastic dominance criterion

  11. Identifying Key Drivers of Return Reversal with Dynamical Bayesian Factor Graph.

    Directory of Open Access Journals (Sweden)

    Shuai Zhao

    Full Text Available In the stock market, return reversal occurs when investors sell overbought stocks and buy oversold stocks, reversing the stocks' price trends. In this paper, we develop a new method to identify key drivers of return reversal by incorporating a comprehensive set of factors derived from different economic theories into one unified dynamical Bayesian factor graph. We then use the model to depict factor relationships and their dynamics, from which we make some interesting discoveries about the mechanism behind return reversals. Through extensive experiments on the US stock market, we conclude that among the various factors, the liquidity factors consistently emerge as key drivers of return reversal, which is in support of the theory of liquidity effect. Specifically, we find that stocks with high turnover rates or high Amihud illiquidity measures have a greater probability of experiencing return reversals. Apart from the consistent drivers, we find other drivers of return reversal that generally change from year to year, and they serve as important characteristics for evaluating the trends of stock returns. Besides, we also identify some seldom discussed yet enlightening inter-factor relationships, one of which shows that stocks in Finance and Insurance industry are more likely to have high Amihud illiquidity measures in comparison with those in other industries. These conclusions are robust for return reversals under different thresholds.

  12. Return Predictability, Model Uncertainty, and Robust Investment

    DEFF Research Database (Denmark)

    Lukas, Manuel

    Stock return predictability is subject to great uncertainty. In this paper we use the model confidence set approach to quantify uncertainty about expected utility from investment, accounting for potential return predictability. For monthly US data and six representative return prediction models, we...... find that confidence sets are very wide, change significantly with the predictor variables, and frequently include expected utilities for which the investor prefers not to invest. The latter motivates a robust investment strategy maximizing the minimal element of the confidence set. The robust investor...... allocates a much lower share of wealth to stocks compared to a standard investor....

  13. Oil Volatility Risk and Expected Stock Returns

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Pan, Xuhui (Nick)

    After the financialization of commodity futures markets in 2004-05 oil volatility has become a strong predictor of returns and volatility of the overall stock market. Furthermore, stocks' exposure to oil volatility risk now drives the cross-section of expected returns. The difference in average...... return between the quintile of stocks with low exposure and high exposure to oil volatility is significant at 0.66% per month, and oil volatility risk carries a significant risk premium of -0.60% per month. In the post-financialization period, oil volatility risk is strongly related with various measures...

  14. Model Specifications for Estimating Labor Market Returns to Associate Degrees: How Robust Are Fixed Effects Estimates? A CAPSEE Working Paper

    Science.gov (United States)

    Belfield, Clive; Bailey, Thomas

    2017-01-01

    Recently, studies have adopted fixed effects modeling to identify the returns to college. This method has the advantage over ordinary least squares estimates in that unobservable, individual-level characteristics that may bias the estimated returns are differenced out. But the method requires extensive longitudinal data and involves complex…

  15. The return of infectious disease.

    Science.gov (United States)

    Garrett, L

    1996-11-01

    This article presents the history of efforts to control the spread of infectious disease from the post-antibiotic era to 1995. Since World War II, public health strategy has focused on the eradication of microbes using powerful medical weaponry. The goal was to push humanity through a ¿health transition,¿ leaving the age of infectious disease permanently behind. But recent developments have shown that this grandiose optimism was premature. As people move across international borders, unwanted microbial hitch-hikers tag along, as happened in the case of Ebola. In large cities, sex industries arise and multiple-partner sex becomes more common, prompting rapid increases in sexually transmitted disease. Moreover, the practice of sharing syringes is a ready vehicle for the transmission of microbes while unhygienic health facilities become centers for the dissemination of disease rather than its control. Black market access to antimicrobials has led to overuse or outright misuse of the drugs and the emergence of resistant bacteria and parasites. Consequently, old organisms, aided by mankind's misuse of disinfectants and drugs, may take on new and more lethal forms. Even when allegations of biological warfare are not flying, it is often difficult to obtain accurate information about outbreaks of disease, particularly in countries dependent on foreign investment or tourism or both. Unfortunately, only 6 laboratories in the world meet security and safety standards that would make them suitable sites for research on the world's deadliest microbes. National security warrants bolder steps involving focusing not only on microbes directly dangerous to humans, but also on those that could pose major threats to crops or livestock. Unfortunately, economic crises have led to budget cuts, particularly in health care, at all levels of government in the US.

  16. Return to work after renal transplantation: a study of the Brazilian Public Social Security System.

    Science.gov (United States)

    Messias, Alexandre Augusto; Reichelt, Angela J; Dos Santos, Edson F; Albuquerque, Galton C; Kramer, José S P; Hirakata, Vania N; Garcia, Valter D

    2014-12-15

    Return to work is an objective parameter used worldwide to evaluate the success of organ transplantation and is especially feasible after renal transplantation. This study sought to describe the frequency of return to work after renal transplantation and related characteristics. Retrospective cohort of 511 isolated kidney transplant recipients was recruited from a Brazilian referral center from January 2005 to December 2009; all were matched to the public social security database to determine inclusion and benefit awards, as well as the rate of resumption of contributions to the public social security system, a surrogate marker of work rehabilitation. Characteristics associated with work return were analyzed. No social security records were found for 28 subjects. The remaining 483 subjects had a mean age of 45±13 years; 62% were male; 401 (83%) received some public social security benefit; 298 were paying dues and could, therefore, receive temporary or permanent disability benefits. Of these, 78 subjects made social security payments after transplantation, resulting in a work return rate of 26% (95% confidence interval, 21-32). Younger age, living donor graft, and chronic glomerulonephritis were significantly associated with return to work. In Brazil, most renal transplant recipients are on social security benefits, but only a small proportion return to work after surgery. Clinical characteristics may help define work resumption trends.

  17. Mathematical biology

    CERN Document Server

    Murray, James D

    1993-01-01

    The book is a textbook (with many exercises) giving an in-depth account of the practical use of mathematical modelling in the biomedical sciences. The mathematical level required is generally not high and the emphasis is on what is required to solve the real biological problem. The subject matter is drawn, e.g. from population biology, reaction kinetics, biological oscillators and switches, Belousov-Zhabotinskii reaction, reaction-diffusion theory, biological wave phenomena, central pattern generators, neural models, spread of epidemics, mechanochemical theory of biological pattern formation and importance in evolution. Most of the models are based on real biological problems and the predictions and explanations offered as a direct result of mathematical analysis of the models are important aspects of the book. The aim is to provide a thorough training in practical mathematical biology and to show how exciting and novel mathematical challenges arise from a genuine interdisciplinary involvement with the biosci...

  18. Habit formation, surplus consumption and return predictability

    DEFF Research Database (Denmark)

    Engsted, Tom; Hyde, Stuart; Vinther Møller, Stig

    2010-01-01

    On an international post World War II dataset, we use an iterated GMM procedure to estimate and test the Campbell and Cochrane (1999, By force of habit: a consumption-based explanation of aggregate stock market behavior. Journal of Political Economy 107, 205–251.) habit formation model with a time......-varying risk-free rate. In addition, we analyze the predictive power of the surplus consumption ratio for future stock and bond returns. We find that, although there are important cross-country differences and economically significant pricing errors, for the majority of countries in our sample the model gets...... significant information about future stock returns, also during the 1990s. In addition, in most countries the surplus consumption ratio is also a powerful predictor of future bond returns. Thus, the surplus consumption ratio captures time-varying expected returns in both stock and bond markets....

  19. DESIGNING THE RETURN MIGRATION OF ROMANIAN STUDENTS

    Directory of Open Access Journals (Sweden)

    Magdalena VELCIU

    2017-05-01

    Full Text Available Romanian youth migration is an increasing phenomenon, due to subjective and objective factors as economical reasons, professional carrer and increasingly more international competition for talent. In these circumstances, the present article aims to evaluate determinant factors that contribute to the decision of Romanian graduates to return national labour market. We sustain that young Romanians consider carefully and hardly decide their professional future. A particular attention is given to their personal reasons and motivations as well as family and friends network. For designing returning factors we present the results of a questionnaire survey, asking young pupils and students about their future educational way and personal reasons underlying the decision to study in a foreign country and taking into consideration the returning decision. As far international student migration is seen as a first step to migration for work, our work desires to fight for returning home of Romanian well-educated graduates.

  20. Simulation of investment returns of toll projects.

    Science.gov (United States)

    2013-08-01

    This research develops a methodological framework to illustrate key stages in applying the simulation of investment returns of toll projects, acting as an example process of helping agencies conduct numerical risk analysis by taking certain uncertain...

  1. Sample Return Systems for Extreme Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — In Phase I we were able to demonstrate that sample return missions utilizing high velocity penetrators (0.1- 1 km/s) could provide substantial new capabilities for...

  2. Mars Sample Return Architecture Assessment Study

    Science.gov (United States)

    Centuori, S.; Hermosín, P.; Martín, J.; De Zaiacomo, G.; Colin, S.; Godfrey, A.; Myles, J.; Johnson, H.; Sachdev, T.; Ahmed, R.

    2018-04-01

    Current paper presents the results of ESA funded activity "Mars Sample Return Architecture Assessment Study" carried-out by DEIMOS Space, Lockheed Martin UK Ampthill, and MDA Corporation, where more than 500 mission design options have been studied.

  3. Paleomagnetic Studies of Returned Samples from Mars

    Science.gov (United States)

    Weiss, B. P.; Beaty, D. W.; McSween, H. Y.; Carrier, B. L.; Czaja, A. D.; Goreva, Y. S.; Hausrath, E.; Herd, C. D. K.; Humayun, M.; McCubbin, F. M.; McLennan, S. M.; Pratt, L. M.; Sephton, M. A.; Steele, A.

    2018-04-01

    Magnetic measurements of returned samples could transform our understanding of the martian dynamo and its connection to climatic and planetary thermal evolution and provide powerful constraints on the preservation state of sample biosignatures.

  4. Sample Return Systems for Extreme Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed work seeks to design, develop and test a hard impact penetrator/sampler that can withstand the hard impact and enable the sample to be returned to...

  5. Should athletes return to activity after cryotherapy?

    Science.gov (United States)

    Pritchard, Kimberly A; Saliba, Susan A

    2014-01-01

    Bleakley CM, Costello JT, Glasgow PD. Should athletes return to sport after applying ice? A systematic review of the effect of local cooling on functional performance. Sports Med. 2012; 42(1):69-87. Does local tissue cooling affect immediate functional performance outcomes in a sport situation? Studies were identified by searching MEDLINE, the Cochrane Central Register of Controlled Trials, and EMBASE, each from the earliest available record through April 2011. Combinations of 18 medical subheadings or key words were used to complete the search. Study Selection : This systematic review included only randomized controlled trials and crossover studies published in English that examined human participants who were treated with a local cooling intervention. At least 1 functional performance outcome that was measured before and after a cooling intervention had to be reported. Excluded were studies using whole-body cryotherapy or cold-water immersion above the waist and studies that measured strength or force production during evoked muscle contraction. Data were extracted by 2 authors using a customized form to evaluate relevant data on study design, eligibility criteria, detailed characteristics of cooling protocols, comparisons, and outcome measures. Disagreement was resolved by consensus or third-party adjudication. To perform an intent-to-treat analysis when possible, data were extracted according to the original allocation groups, and losses to follow-up were noted. The review authors were not blinded to the study author, institution, or journal. For each study, mean differences or standardized mean differences and 95% confidence intervals were calculated for continuous outcomes using RevMan (version 5.1; The Nordic Cochrane Centre, Copenhagen, Denmark). Treatment effects were based on between-groups comparisons (cryotherapy versus control) using postintervention outcomes or within-group comparisons (precryotherapy versus postcryotherapy). If continuous data were

  6. Volatility smile and stochastic arbitrage returns

    OpenAIRE

    Sergei Fedotov; Stephanos Panayides

    2004-01-01

    The purpose of this work is to explore the role that random arbitrage opportunities play in pricing financial derivatives. We use a non-equilibrium model to set up a stochastic portfolio, and for the random arbitrage return, we choose a stationary ergodic random process rapidly varying in time. We exploit the fact that option price and random arbitrage returns change on different time scales which allows us to develop an asymptotic pricing theory involving the central limit theorem for random...

  7. Returning to Work After Electrical Injuries

    DEFF Research Database (Denmark)

    Stergiou-Kita, M.; Mansfield, E.; Bayley, M.

    2014-01-01

    were conducted with individuals who experienced an electrical injury at the workplace. Participants were recruited from specialized burns rehabilitation programs in Ontario, Canada. Interviews were transcribed verbatim and thematic analysis used to analyze the qualitative interviews. Data regarding......The objective of this study was to gain an understanding of workers' experiences with returning to work, the challenges they experienced, and the supports they found most beneficial when returning to work after a workplace electrical injury. Thirteen semistructured qualitative telephone interviews...

  8. Are fund of hedge fund returns asymmetric?

    OpenAIRE

    Lynch, Margaret; Hutson, Elaine; Stevenson, Max

    2004-01-01

    We examine the return distributions of 332 funds of hedge funds and associated indices. Over half of the sample is significantly skewed according to the skewness statistic, and these are split 50/50 positive and negative. However, we argue that the skewness statistic can lead to erroneous inferences regarding the nature of the return distribution, because the test statistic is based on the normal distribution. Using a series of tests that make minimal assumptions about the shape of the ...

  9. Return to Golf After Lumbar Fusion.

    Science.gov (United States)

    Shifflett, Grant D; Hellman, Michael D; Louie, Philip K; Mikhail, Christopher; Park, Kevin U; Phillips, Frank M

    Spinal fusion surgery is being increasingly performed, yet few studies have focused on return to recreational sports after lumbar fusion and none have specifically analyzed return to golf. Most golfers successfully return to sport after lumbar fusion surgery. Case series. Level 4. All patients who underwent 1- or 2-level primary lumbar fusion surgery for degenerative pathologies performed by a single surgeon between January 2008 and October 2012 and had at least 1-year follow-up were included. Patients completed a specifically designed golf survey. Surveys were mailed, given during follow-up clinic, or answered during telephone contact. A total of 353 patients met the inclusion and exclusion criteria, with 200 responses (57%) to the questionnaire producing 34 golfers. The average age of golfers was 57 years (range, 32-79 years). In 79% of golfers, preoperative back and/or leg pain significantly affected their ability to play golf. Within 1 year from surgery, 65% of patients returned to practice and 52% returned to course play. Only 29% of patients stated that continued back/leg pain limited their play. Twenty-five patients (77%) were able to play the same amount of golf or more than before fusion surgery. Of those providing handicaps, 12 (80%) reported the same or an improved handicap. More than 50% of golfers return to on-course play within 1 year of lumbar fusion surgery. The majority of golfers can return to preoperative levels in terms of performance (handicap) and frequency of play. This investigation offers insight into when golfers return to sport after lumbar fusion surgery and provides surgeons with information to set realistic expectations postoperatively.

  10. Return models and dynamic asset allocation strategies

    OpenAIRE

    Shi, Wyanet Wen

    2017-01-01

    This thesis studies the design of optimal investment strategies. A strategy is considered optimal when it minimizes the variance of terminal portfolio wealth for a given level of expected terminal portfolio wealth, or equivalently, maximizes an investor's utility. We study this issue in two particular situations: when asset returns follow a continuous-time path-independent process, and when they follow a discrete-time path-dependent process. Continuous-time path-independent return mode...

  11. Job Training: Costs, Returns, and Wage Profiles

    OpenAIRE

    Jacob Mincer

    1989-01-01

    Using information on time costs of training and gains in wages attributable to training I computed rates of return on training investments. The range of estimates based on several data sets generally exceeds the magnitudes of rates of return usually observed for schooling investments. It is not clear, however, that the difference represents underinvestment in job training. Two methods were used to estimate total annual costs of job training in the U.S. economy, for 1958, 1976, and 1987. The "...

  12. Returns to beauty over the life course

    DEFF Research Database (Denmark)

    Jæger, Mads Meier

    ’ facial attractiveness as well as data on SES, marital, and health outcomes from their mid-20s to their mid-60s. I find that beauty has lasting positive returns for women since more beautiful women have higher SES throughout their working life, have a higher probability of being married at age 25......, and marry high-SES husbands. I find no effects of beauty on health and, in general, no returns to beauty for men....

  13. Industry Returns and the Fisher Effect.

    OpenAIRE

    Boudoukh, Jacob; Richardson, Matthew; Whitelaw, Robert F

    1994-01-01

    The authors investigate the cross-sectional relation between industry-sorted stock returns and expected inflation, and they find that this relation is linked to cyclical movements in industry output. Stock returns of noncyclical industries tend to covary positively with expected inflation, while the reverse holds for cyclical industries. From a theoretical perspective, the authors describe a model that captures both (1) the cross-sectional variation in these relations across industries and (2...

  14. Analyzing the Biology on the System Level

    OpenAIRE

    Tong, Wei

    2016-01-01

    Although various genome projects have provided us enormous static sequence information, understanding of the sophisticated biology continues to require integrating the computational modeling, system analysis, technology development for experiments, and quantitative experiments all together to analyze the biology architecture on various levels, which is just the origin of systems biology subject. This review discusses the object, its characteristics, and research attentions in systems biology,...

  15. Workplace disability management programs promoting return-to-work

    DEFF Research Database (Denmark)

    Gensby, Ulrik; Lund, Thomas; Kowalski, Krystyna

    This report presents a Campbell systematic review on the effectiveness of workplace disability management programs (WPDM programs) promoting return to work (RTW), as implemented and practised by employers. The objectives of this review were to assess the effects of WPDM programs, to examine...... non-randomized studies (NRS) and eleven single group ‘before and after’ studies (B & A)), including data from eleven different WPDM programs, met the inclusion criteria. There were insufficient data on the characteristics of the sample and the effect sizes were uncertain. There is a lack of evidence...

  16. Mars Earth Return Vehicle (MERV) Propulsion Options

    Science.gov (United States)

    Oleson, Steven R.; McGuire, Melissa L.; Burke, Laura; Fincannon, James; Warner, Joe; Williams, Glenn; Parkey, Thomas; Colozza, Tony; Fittje, Jim; Martini, Mike; hide

    2010-01-01

    The COMPASS Team was tasked with the design of a Mars Sample Return Vehicle. The current Mars sample return mission is a joint National Aeronautics and Space Administration (NASA) and European Space Agency (ESA) mission, with ESA contributing the launch vehicle for the Mars Sample Return Vehicle. The COMPASS Team ran a series of design trades for this Mars sample return vehicle. Four design options were investigated: Chemical Return /solar electric propulsion (SEP) stage outbound, all-SEP, all chemical and chemical with aerobraking. The all-SEP and Chemical with aerobraking were deemed the best choices for comparison. SEP can eliminate both the Earth flyby and the aerobraking maneuver (both considered high risk by the Mars Sample Return Project) required by the chemical propulsion option but also require long low thrust spiral times. However this is offset somewhat by the chemical/aerobrake missions use of an Earth flyby and aerobraking which also take many months. Cost and risk analyses are used to further differentiate the all-SEP and Chemical/Aerobrake options.

  17. Linkage between company scores and stock returns

    Directory of Open Access Journals (Sweden)

    Saban Celik

    2017-12-01

    Full Text Available Previous studies on company scores conducted at firm-level, generally concluded that there exists a positive relation between company scores and stock returns. Motivated by these studies, this study examines the relationship between company scores (Corporate Governance Score, Economic Score, Environmental Score, and Social Score and stock returns, both at portfolio-level analysis and firm-level cross-sectional regressions. In portfolio-level analysis, stocks are sorted based on each company scores and quintile portfolio are formed with different levels of company scores. Then, existence and significance of raw returns and risk-adjusted returns difference between portfolios with the extreme company scores (portfolio 10 and portfolio 1 is tested. In addition, firm-level cross-sectional regression is performed to examine the significance of company scores effects with control variables. While portfolio-level analysis results indicate that there is no significant relation between company scores and stock returns; firm-level analysis indicates that economic, environmental, and social scores have effect on stock returns, however, significance and direction of these effects change, depending on the included control variables in the cross-sectional regression.

  18. Return to Work After Acute Myocardial Infarction: Comparison Between Young Women and Men.

    Science.gov (United States)

    Dreyer, Rachel P; Xu, Xiao; Zhang, Weiwei; Du, Xue; Strait, Kelly M; Bierlein, Maggie; Bucholz, Emily M; Geda, Mary; Fox, James; D'Onofrio, Gail; Lichtman, Judith H; Bueno, Héctor; Spertus, John A; Krumholz, Harlan M

    2016-02-01

    Return to work after acute myocardial infarction (AMI) is an important outcome and is particularly relevant to young patients. Women may be at a greater risk for not returning to work given evidence of their worse recovery after AMI than similarly aged men. However, sex differences in return to work after AMI has not been studied extensively in a young population (≤ 55 years). We analyzed data from 1680 patients with AMI aged 18 to 55 years (57% women) participating in the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study who were working full time (≥ 35 hours) before the event. Data were obtained by medical record abstraction and patient interviews. We conducted multivariable regression analyses to examine sex differences in return to work at 12 months after AMI, and the association of patient characteristics with return to work. When compared with young men, young women were less likely to return to work (89% versus 85%; 85% versus 89%, P=0.02); however, this sex difference was not significant after adjusting for patient sociodemographic characteristics, psychosocial factors, and health measures. Being married, engaging in a professional or clerical type of work, having more favorable physical health, and having no previous coronary disease or hypertension were significantly associated with a higher likelihood of return to work at 12 months. Among a young population, women are less likely to return to work after AMI than men. This disadvantage is explained by differences in demographic, occupational, and health characteristics. © 2016 American Heart Association, Inc.

  19. 26 CFR 301.6103(h)(2)-1 - Disclosure of returns and return information (including taxpayer return information) to and by...

    Science.gov (United States)

    2010-04-01

    ... administration. 301.6103(h)(2)-1 Section 301.6103(h)(2)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Returns Returns and Records § 301.6103(h)(2)-1 Disclosure of returns and return information (including..., shall, to the extent provided by section 6103(h)(2) (A), (B), and (C) and subject to the requirements of...

  20. Biological therapeutics

    National Research Council Canada - National Science Library

    Greenstein, Ben; Brook, Daniel A

    2011-01-01

    This introductory textbook covers all the main categories of biological medicines, including vaccines, hormonal preparations, drugs for rheumatoid arthritis and other connective tissue diseases, drugs...

  1. Fate of return activated sludge after ozonation: an optimization study for sludge disintegration.

    Science.gov (United States)

    Demir, Ozlem; Filibeli, Ayse

    2012-09-01

    The effects of ozonation on sludge disintegration should be investigated before the application of ozone during biological treatment, in order to minimize excess sludge production. In this study, changes in sludge and supernatant after ozonation of return activated sludge were investigated for seven different ozone doses. The optimum ozone dose to avoid inhibition of ozonation and high ozone cost was determined in terms of disintegration degree as 0.05 g O3/gTS. Suspended solid and volatile suspended solid concentrations of sludge decreased by 77.8% and 71.6%, respectively, at the optimum ozone dose. Ozonation significantly decomposed sludge flocs. The release of cell contents was proved by the increase of supernatant total nitrogen (TN) and phosphorus (TP). While TN increased from 7 mg/L to 151 mg/L, TP increased from 8.8 to 33 mg/L at the optimum ozone dose. The dewaterability and filterability characteristics of the ozonated sludge were also examined. Capillary suction time increased with increasing ozone dosage, but specific resistance to filtration increased to a specific value and then decreased dramatically. The particle size distribution changed significantly as a result of floc disruption at an optimum dose of 0.05 gO3/gTS.

  2. How Are Property Investment Returns Determined? : Estimating the Micro-Structure of Asset Prices, Property Income, and Discount Rates

    OpenAIRE

    Shimizu, Chihiro

    2014-01-01

    How exactly should one estimate property investment returns? Investors in property aim to maximize capital gains from price increases and income generated by the property. How are the returns on investment in property determined based on its characteristics, and what kind of market characteristics does it have? Focusing on the Tokyo commercial property market and residential property market, the purpose of this paper was to break down and measure the micro-structure of property investment ret...

  3. Correlation between morphological and biological characteristics of ...

    African Journals Online (AJOL)

    Aria TM

    2012-07-05

    Jul 5, 2012 ... mesenchymal stem cells (MSCs) and MSCs-derived hepatocytes, in vitro, and their correlation with ... way for drug metabolism and hepatotoxicity studies ... squared test and a level of 0.05 or less was considered significant.

  4. Correlation between morphological and biological characteristics of ...

    African Journals Online (AJOL)

    Hepatocyte dysfunction with the possibility of eventual organ failure is created from most liver diseases. Images of cell morphology can be obtained nondestructively using a conventional inverted microscope. Therefore, this study attempted to investigate several morphological parameters of mesenchymal stem cells (MSCs) ...

  5. Establishment and biological characteristics of Piedmontese cattle ...

    African Journals Online (AJOL)

    use

    2011-12-12

    Dec 12, 2011 ... 1Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. ... Piedmontese cattle were obtained from the Institute of Animal ..... organotypical brain slice model. ... Mitosis enhances.

  6. Establishment and biological characteristics of Piedmontese cattle ...

    African Journals Online (AJOL)

    use

    2011-12-12

    Dec 12, 2011 ... 2.30 ± 0.48. T. 12. 3.25 ± 0.17. T. 27. 2.19 ± 0.13. T. 13. 3.25 ± 0.29. T. 28. 2.19 ± 0.33. T. 14 .... technique has been used for many years and is still being used today, practice .... tissue culture and the nude mouse. Tissue Cell.

  7. "Protected biological control"- Biological pest management in the greenhouse industry

    NARCIS (Netherlands)

    Pilkington, L.J.; Messelink, G.J.; Lenteren, van J.C.; Mottee, Le K.

    2010-01-01

    This paper briefly describes the foundations and characteristics of biological control in protected cropping and what drivers are behind adoption of this management system within this industry. Examining a brief history of biological control in greenhouses and what makes it a successful management

  8. Temporal Oculomotor Inhibition of Return and Spatial Facilitation of Return in a Visual Encoding Task

    Directory of Open Access Journals (Sweden)

    Steven G Luke

    2013-07-01

    Full Text Available Oculomotor inhibition of return (O-IOR is an increase in saccade latency prior to an eye movement to a recently fixated location compared to other locations. It has been proposed that this temporal O-IOR may have spatial consequences, facilitating foraging by inhibiting return to previously attended regions. In order to test this possibility, participants viewed arrays of objects and of words while their eye movements were recorded. Temporal O-IOR was observed, with equivalent effects for object and word arrays, indicating that temporal O-IOR is an oculomotor phenomenon independent of array content. There was no evidence for spatial inhibition of return. Instead, spatial facilitation of return was observed: Participants were significantly more likely than chance to make return saccades and to refixate just-visited locations. Further, the likelihood of making a return saccade to an object or word was contingent on the amount of time spent viewing that object or word before leaving it. This suggests that, unlike temporal O-IOR, return probability is influenced by cognitive processing. Taken together, these results are inconsistent with the hypothesis that inhibition of return functions as a foraging facilitator. The results also provide strong evidence for a different oculomotor bias that could serve as a foraging facilitator: saccadic momentum, a tendency to repeat the most recently executed saccade program. We suggest that models of visual attention could incorporate saccadic momentum in place of inhibition of return.

  9. Role of disease and demographic factors as determinants of return migration

    DEFF Research Database (Denmark)

    Handlos, Line Neerup; Petersen, Jorgen Holm; Bygbjerg, Ib Christian

    2017-01-01

    AIMS: A number of aspects of the health status of migrants who return to their country of origin have been explored in the literature; however, a more general description of the incidence of disease and demographic characteristics is lacking. The aim of this research was to contribute such a desc......AIMS: A number of aspects of the health status of migrants who return to their country of origin have been explored in the literature; however, a more general description of the incidence of disease and demographic characteristics is lacking. The aim of this research was to contribute...

  10. Is synthetic biology mechanical biology?

    Science.gov (United States)

    Holm, Sune

    2015-12-01

    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  11. Frequency and Reasons for Return to Acute Care in Leukemia Patients Undergoing Inpatient Rehabilitation

    Science.gov (United States)

    Fu, Jack Brian; Lee, Jay; Smith, Dennis W.; Bruera, Eduardo

    2012-01-01

    Objective To assess the frequency and reasons for return to the primary acute care service among leukemia patients undergoing inpatient rehabilitation. Design Retrospective study of all patients with leukemia, myelodysplastic syndrome, aplastic anemia, or myelofibrosis admitted to inpatient rehabilitation at a tertiary referral-based cancer center between January 1, 2005, and April 10, 2012. Items analyzed from patient records included return to the primary acute care service with demographic information, leukemia characteristics, medications, hospital admission characteristics, and laboratory values. Results 225 patients were admitted a total of 255 times. 93/255 (37%) of leukemia inpatient rehabilitation admissions returned to the primary acute care service. 18/93 (19%) and 42/93 (45%) of these patients died in the hospital and were discharged home respectively. Statistically significant factors (p<.05) associated with return to the primary acute care service include peripheral blast percentage and the presence of an antifungal agent on the day of inpatient rehabilitation transfer. Using an additional two factors (platelet count and the presence of an antiviral agent both with a p<.11), a Return To Primary (RTP) - Leukemia index was formulated. Conclusions Leukemia patients with the presence of circulating peripheral blasts and/or antifungal agent may be at increased risk of return to the primary acute care service. The RTP-Leukemia index should be tested in prospective studies to determine its usefulness. PMID:23117267

  12. ACL Return to Sport Guidelines and Criteria.

    Science.gov (United States)

    Davies, George J; McCarty, Eric; Provencher, Matthew; Manske, Robert C

    2017-09-01

    Because of the epidemiological incidence of anterior cruciate ligament (ACL) injuries, the high reinjury rates that occur when returning back to sports, the actual number of patients that return to the same premorbid level of competition, the high incidence of osteoarthritis at 5-10-year follow-ups, and the effects on the long-term health of the knee and the quality of life for the patient, individualizing the return to sports after ACL reconstruction (ACL-R) is critical. However, one of the challenging but unsolved dilemmas is what criteria and clinical decision making should be used to return an athlete back to sports following an ACL-R. This article describes an example of a functional testing algorithm (FTA) as one method for clinical decision making based on quantitative and qualitative testing and assessment utilized to make informed decisions to return an athlete to their sports safely and without compromised performance. The methods were a review of the best current evidence to support a FTA. In order to evaluate all the complicated domains of the clinical decision making for individualizing the return to sports after ACL-R, numerous assessments need to be performed including the biopsychosocial concepts, impairment testing, strength and power testing, functional testing, and patient-reported outcomes (PROs). The optimum criteria to use for individualizing the return to sports after ACL-R remain elusive. However, since this decision needs to be made on a regular basis with the safety and performance factors of the patient involved, this FTA provides one method of quantitatively and qualitatively making the decisions. Admittedly, there is no predictive validity of this system, but it does provide practical guidelines to facilitate the clinical decision making process for return to sports. The clinical decision to return an athlete back into competition has significant implications ranging from the safety of the athlete, to performance factors and actual

  13. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  14. Mesoscopic biology

    Indian Academy of Sciences (India)

    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological ...

  15. The return trip is felt shorter only postdictively: A psychophysiological study of the return trip effect [corrected].

    Directory of Open Access Journals (Sweden)

    Ryosuke Ozawa

    Full Text Available The return trip often seems shorter than the outward trip even when the distance and actual time are identical. To date, studies on the return trip effect have failed to confirm its existence in a situation that is ecologically valid in terms of environment and duration. In addition, physiological influences as part of fundamental timing mechanisms in daily activities have not been investigated in the time perception literature. The present study compared round-trip and non-round-trip conditions in an ecological situation. Time estimation in real time and postdictive estimation were used to clarify the situations where the return trip effect occurs. Autonomic nervous system activity was evaluated from the electrocardiogram using the Lorenz plot to demonstrate the relationship between time perception and physiological indices. The results suggest that the return trip effect is caused only postdictively. Electrocardiographic analysis revealed that the two experimental conditions induced different responses in the autonomic nervous system, particularly in sympathetic nervous function, and that parasympathetic function correlated with postdictive timing. To account for the main findings, the discrepancy between the two time estimates is discussed in the light of timing strategies, i.e., prospective and retrospective timing, which reflect different emphasis on attention and memory processes. Also each timing method, i.e., the verbal estimation, production or comparative judgment, has different characteristics such as the quantification of duration in time units or knowledge of the target duration, which may be responsible for the discrepancy. The relationship between postdictive time estimation and the parasympathetic nervous system is also discussed.

  16. HUBUNGAN RETURN SAHAM DAN INFLASI DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Nyoman Triaryati

    2017-03-01

    Full Text Available The effect of inflation to the stock return research had been held since three decades ago based on GeneralizeFisher’s Hypotheses, but ‘how inflation influenced stock return’ had become a debate until today. In Indonesiamost of the related research used inflation as one of the variables that influenced stock return despite of others inshort period of time. This research investigated the effect of inflation to the stock return in Indonesia within fifteenyears, which was divided into 3 (three periods of time reflecting different economic growth for each of it. Thepurpose of this allotment was to see the consistency how inflation influenced the stock market. Using a secondarydata from monthly inflation and IHSG period 1998 until 2012, included three hundred and sixty observation,simple regression model analyses was applied. This research acknowledged that inflation negatively influencedstock return in a long time period, but it did not exist in the short time period, except when the level of inflationreached 10%. In conclusion, inflation influence on the stock return was not ascertained by how long the investigationwas held but if there was any inflation rate reaching 10% within the period of investigation.

  17. Exploring Longitudinal Risk-return Relationships

    DEFF Research Database (Denmark)

    Andersen, Torben J.; Bettis, Richard A.

    2015-01-01

    We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk and a stoch......We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk...... can lead to the inverse longitudinal risk-return relationships observed empirically. We discuss this apparent paradox and the possible resolution between mindless and conscious behavior as plausible causes of the longitudinal Bowman Paradox....

  18. Macro factors in oil futures returns

    International Nuclear Information System (INIS)

    Le Pen, Yannick; Sevi, Benoit

    2012-01-01

    We investigate the macro factors that can explain the monthly oil futures return for the NYMEX WTI futures contract for the time period 1993:11 to 2010:03. We build a new database of 187 real and nominal macro-economic variables from developed and emerging countries and resort to the large factor approximate model to extract 9 factors from this dataset. We then regress crude oil return on several combinations of these factors. Our best model explains around 38% of the variability of oil futures return. More interestingly, the factor which has the largest influence on crude oil price is related to real variables from emerging countries. This result confirms the latest finding in the literature that the recent evolution in oil price is attributable to change in supply and demand conditions and not to the large increase in trading activity from speculators. (authors)

  19. Bond return predictability in expansions and recessions

    DEFF Research Database (Denmark)

    Engsted, Tom; Møller, Stig Vinther; Jensen, Magnus David Sander

    We document that over the period 1953-2011 US bond returns are predictable in expansionary periods but unpredictable during recessions. This result holds in both in-sample and out-of-sample analyses and using both univariate regressions and combination forecasting techniques. A simulation study...... but negative in recessions. The results are also consistent with tests showing that the expectations hypothesis of the term structure holds in recessions but not in expansions. However, the results for bonds are in sharp contrast to results for stocks showing that stock returns are predictable in recessions...... but not in expansions. Thus, our results indicate that there is not a common predictive pattern of stock and bond returns associated with the state of the economy....

  20. Cesium return program lessons learned FY 1994

    International Nuclear Information System (INIS)

    Clements, E.P.

    1994-08-01

    The U.S. Department of Energy (DOE) is returning leased cesium capsules from IOTECH, Incorporated (IOTECH), Northglenn, Colorado, and the Applied Radiant Energy Company (ARECO), Lynchburg, Virginia, to the Waste Encapsulation and Storage Facility (WESF) on the Hanford Site, to ensure safe management and storage, pending final capsule disposition. Preparations included testing and modifying the Beneficial Uses Shipping System (BUSS) cask, preparing an Environmental Assessment (EA), development of a comprehensive Transportation Plan, coordination with the Western Governors' Association (WGA) and the Confederated Tribes of the Umatilla Indian Reservation (CTUIR), and interface with the public and media. Additional activities include contracting for a General Electric (GE) 2000 cask to expedite IOTECH capsule returns, and coordination with Eastern and Midwestern States to revise the transportation plan in support of ARECO capsule returns

  1. The Importance of Sample Return in Establishing Chemical Evidence for Life on Mars or Other Solar System Bodies

    Science.gov (United States)

    Glavin, D. P.; Conrad, P.; Dworkin, J. P.; Eigenbrode, J.; Mahaffy, P. R.

    2011-01-01

    The search for evidence of life on Mars and elsewhere will continue to be one of the primary goals of NASA s robotic exploration program over the next decade. NASA and ESA are currently planning a series of robotic missions to Mars with the goal of understanding its climate, resources, and potential for harboring past or present life. One key goal will be the search for chemical biomarkers including complex organic compounds important in life on Earth. These include amino acids, the monomer building blocks of proteins and enzymes, nucleobases and sugars which form the backbone of DNA and RNA, and lipids, the structural components of cell membranes. Many of these organic compounds can also be formed abiotically as demonstrated by their prevalence in carbonaceous meteorites [1], though, their molecular characteristics may distinguish a biological source [2]. It is possible that in situ instruments may reveal such characteristics, however, return of the right sample (i.e. one with biosignatures or having a high probability of biosignatures) to Earth would allow for more intensive laboratory studies using a broad array of powerful instrumentation for bulk characterization, molecular detection, isotopic and enantiomeric compositions, and spatially resolved chemistry that may be required for confirmation of extant or extinct Martian life. Here we will discuss the current analytical capabilities and strategies for the detection of organics on the Mars Science Laboratory (MSL) using the Sample Analysis at Mars (SAM) instrument suite and how sample return missions from Mars and other targets of astrobiological interest will help advance our understanding of chemical biosignatures in the solar system.

  2. CHARACTERISTICS OF MIRR METHOD IN EVALUATION OF INVESTMENT PROJECTS' EFFECTIVENESS

    Directory of Open Access Journals (Sweden)

    P. Kukhta

    2014-09-01

    Full Text Available There were analyzed characteristics of the Modified Internal Rate of Return method in the evaluation of investment projects, restrictions connected with its application, advantages and disadvantages compared with indicators of the original Internal Rate of Return and Net Present Value for projects with certain baseline characteristics. It was determined opportunities to adapt the method of Modified Internal Rate of Return to alternative computational approaches of the project cash flows evaluation.

  3. CHARACTERISTICS OF MIRR METHOD IN EVALUATION OF INVESTMENT PROJECTS' EFFECTIVENESS

    OpenAIRE

    P. Kukhta

    2014-01-01

    There were analyzed characteristics of the Modified Internal Rate of Return method in the evaluation of investment projects, restrictions connected with its application, advantages and disadvantages compared with indicators of the original Internal Rate of Return and Net Present Value for projects with certain baseline characteristics. It was determined opportunities to adapt the method of Modified Internal Rate of Return to alternative computational approaches of the project cash flows evalu...

  4. 26 CFR 20.6018-2 - Returns; person required to file return.

    Science.gov (United States)

    2010-04-01

    ... executor or administrator shall file the return. If there is more than one executor or administrator, the return must be made jointly by all. If there is no executor or administrator appointed, qualified and... decedent situated in the United States is constituted an executor for purposes of the tax (see § 20.2203-1...

  5. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi

    2009-06-01

    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  6. Risk and return in oilfield asset holdings

    Energy Technology Data Exchange (ETDEWEB)

    Kretzschmar, Gavin L.; Kirchner, Axel; Reusch, Hans [University of Edinburgh, College of Humanities and Social Sciences, The Management School (United Kingdom)

    2008-11-15

    Convention suggests that emerging market investment should provide commensurately lower risk or higher returns than comparable assets in developed countries. This study demonstrates that emerging markets contain regulatory specificities that challenge asset valuation model convergence and potentially invert risk return convention. 292 oilfield assets are used to provide evidence that, under upward oil prices, emerging markets are characterized by progressive state participation in oilfield cash flows. Specifically, this work advances the low oil price paradigm of prior oil and gas asset valuation studies and provides evidence that emerging market state participation terms limit the corporate value of globalization for the sector. (author)

  7. Risk and return in oilfield asset holdings

    International Nuclear Information System (INIS)

    Kretzschmar, Gavin L.; Kirchner, Axel; Reusch, Hans

    2008-01-01

    Convention suggests that emerging market investment should provide commensurately lower risk or higher returns than comparable assets in developed countries. This study demonstrates that emerging markets contain regulatory specificities that challenge asset valuation model convergence and potentially invert risk return convention. 292 oilfield assets are used to provide evidence that, under upward oil prices, emerging markets are characterized by progressive state participation in oilfield cash flows. Specifically, this work advances the low oil price paradigm of prior oil and gas asset valuation studies and provides evidence that emerging market state participation terms limit the corporate value of globalization for the sector. (author)

  8. Tail Risk Premia and Return Predictability

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Todorov, Viktor; Xu, Lai

    The variance risk premium, defined as the difference between actual and risk-neutralized expectations of the forward aggregate market variation, helps predict future market returns. Relying on new essentially model-free estimation procedure, we show that much of this predictability may be attribu......The variance risk premium, defined as the difference between actual and risk-neutralized expectations of the forward aggregate market variation, helps predict future market returns. Relying on new essentially model-free estimation procedure, we show that much of this predictability may......-varying economic uncertainty and changes in risk aversion, or market fears, respectively....

  9. Return on experience. Building tomorrow's safety rules

    International Nuclear Information System (INIS)

    Anon.

    2013-01-01

    Based on some experiments and witnesses, this set of articles outlines the importance of the return on experience in the evolution of process for improving the safety of nuclear installations. As an example, an article notably addresses the failures of Diesel engines which are used as spare generators in nuclear power stations: failures have been analysed and attributed to bearings, and more specifically to the degradation of their surface, and a third generation of bearings has been designed and produced. An article outlines that different industrials belonging to the nuclear sector as well as to other sectors share their returns on experience

  10. Principais características biológicas e sociais do recém-nascido de baixo peso The main biological and social characteristics of children low birth-weight

    Directory of Open Access Journals (Sweden)

    João Yunes

    1978-09-01

    Full Text Available Estudou-se as principais características biológicas e sociais do recém-nascido de baixo peso (£ 2.500 g comparado com o de peso normal (> 2.500 através de uma amostra de recém-nascidos admitidos no berçário e nascidos na Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da USP durante o período de 1 ano. As características individuais do recém-nascido foram avaliadas através das variáveis sexo, cor, medidas antropométricas e condições clínicas. A assistência dispensada ao recém-nascido foi estudada quer sob o ponto de vista quantitativo como qualitativo. As condições sócio-econômicas foram analisadas através da caracterização ao tamanho da família, tipo de união, qualificação da mão de obra, escolaridade e renda. Também foram analisados o comportamento e a atitude das mães dos recém-nascidos quanto à utilização dos recursos de saúde, idade ideal para ter filhos e número ideal de filhos. As principais características médico-sociais identificadas e analisadas neste estudo fornecem elementos para subsidiar o estabelecimento de uma assistência global à gestante.A study was made on the main biological and social characteristics of low birth-weight (£ 2500 g as compared to normal weight (> 2500 g based on a sample of newborn admited to the nursery and born at the "Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo" during the period of one year. The individual characteristics of the new-born were evaluated according to the variables sex, color, anthropometric measures and clinical conditions. Medical care given to new-born was studied not only as to the aspect of quantity but also of quality. Social-economic conditions were analyzed based on the characterization of family size, legal conditions of marriage, man-power qualification, schooling and income. Behavior and attitudes of mothers of the newborn were also analyzed as regards the

  11. Biological desulfurisation

    Energy Technology Data Exchange (ETDEWEB)

    Arena, B.J. [UOP LLC (United States); Benschop, A.; Janssen, A. [Paques Natural Solutions (Netherlands); Kijlstra, S. [Shell Global Solutions (Netherlands)

    2001-03-01

    This article focuses on the biological THIOPAQ process for removing hydrogen sulphide from refinery gases and recovering elemental sulphur. Details are given of the process which absorbs hydrogen sulphide-containing gas in alkaline solution prior to oxidation of the dissolved sulphur to elemental sulphur in a THIOPAQ aerobic biological reactor, with regeneration of the caustic solution. Sulphur handling options including sulphur wash, the drying of the sulphur cake, and sulphur smelting by pressure liquefaction are described. Agricultural applications of the biologically recovered sulphur, and application of the THIOPAQ process to sulphur recovery are discussed.

  12. Systems Biology

    Indian Academy of Sciences (India)

    IAS Admin

    study and understand the function of biological systems, particu- larly, the response of such .... understand the organisation and behaviour of prokaryotic sys- tems. ... relationship of the structure of a target molecule to its ability to bind a certain ...

  13. The effect of maternity leave length and time of return to work on breastfeeding.

    Science.gov (United States)

    Ogbuanu, Chinelo; Glover, Saundra; Probst, Janice; Liu, Jihong; Hussey, James

    2011-06-01

    We investigated the effect of maternity leave length and time of first return to work on breastfeeding. Data were from the Early Childhood Longitudinal Study-Birth Cohort. Restricting our sample to singletons whose biological mothers were the respondents at the 9-month interview and worked in the 12 months before delivery (N = 6150), we classified the length of total maternity leave (weeks) as 1 to 6, 7 to 12, ≥ 13, and did not take; paid maternity leave (weeks) as 0, 1 to 6, ≥ 7, and did not take; and time of return to work postpartum (weeks) as 1 to 6, 7 to 12, ≥ 13, and not yet returned. Analyses included χ(2) tests and multiple logistic regressions. In our study population, 69.4% initiated breastfeeding with positive variation by both total and paid maternity leave length, and time of return to work. In adjusted analyses, neither total nor paid maternity leave length had any impact on breastfeeding initiation or duration. Compared with those returning to work within 1 to 6 weeks, women who had not yet returned to work had a greater odds of initiating breastfeeding (odds ratio [OR]: 1.46 [1.08-1.97]; risk ratios [RR]: 1.13 [1.03-1.22]), continuing any breastfeeding beyond 6 months (OR: 1.41 [0.87-2.27]; RR: 1.25 [0.91-1.61]), and predominant breastfeeding beyond 3 months (OR: 2.01 [1.06-3.80]; RR: 1.70 [1.05-2.53]). Women who returned to work at or after 13 weeks postpartum had higher odds of predominantly breastfeeding beyond 3 months (OR: 2.54 [1.51-4.27]; RR: 1.99 [1.38-2.69]). If new mothers delay their time of return to work, then duration of breastfeeding among US mothers may lengthen.

  14. Return to work: Police personnel and PTSD

    NARCIS (Netherlands)

    Plat, Marie-Christine J.; Westerveld, Gre J.; Hutter, Renée C.; Olff, Miranda; Frings-Dresen, Monique H. W.; Sluiter, Judith K.

    2013-01-01

    This study i) describes the number of police personnel with PTSD who are working and those who are on sick leave before and after an out-patient-clinic treatment program and ii) examines which factors are related to return to work. Police personnel treated for PTSD (n=121). In this retrospective

  15. An Editor's Journey: Return to Haiti

    Science.gov (United States)

    Moy, Yvette

    2012-01-01

    This paper recounts the author's story as she returned to Haiti in February to join a building project near Port-Au-Prince and to document efforts by U.S. higher education institutions to help the country rebound from the devastating 2010 earthquake. The author describes how consortiums have been formed in order to support the development of the…

  16. Return of IAEA assistance team from Thailand

    International Nuclear Information System (INIS)

    2000-01-01

    The document informs about the return from Thailand of the IAEA team sent (upon the request of the Thai Government under the Convention on Assistance in Case of a Nuclear Accident or Radiological Emergency) to Bangkok to help Thai counterparts in the wake of an accident involving a discarded radioactive cobalt 60 source used in hospitals

  17. 7 CFR 356.8 - Return procedure.

    Science.gov (United States)

    2010-01-01

    ... receipt provided by Plant Protection and Quarantine, the seized property is authorized to be released. ... 7 Agriculture 5 2010-01-01 2010-01-01 false Return procedure. 356.8 Section 356.8 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE...

  18. Inflation risk and international asset returns

    NARCIS (Netherlands)

    G.A. Moerman (Gerard); M.A. van Dijk (Mathijs)

    2010-01-01

    textabstractWe show that inflation risk is priced in international asset returns. We analyze inflation risk in a framework that encompasses the International Capital Asset Pricing Model (ICAPM) of Adler and Dumas (1983). In contrast to the extant empirical literature on the ICAPM, we relax the

  19. Oil Volatility Risk and Expected Stock Returns

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Pan, Xuhui (Nick)

    return between the quintile of stocks with low exposure and high exposure to oil volatility is significant at 0.66% per month, and oil volatility risk carries a significant risk premium of -0.60% per month. In the post-financialization period, oil volatility risk is strongly related with various measures...

  20. Expected Stock Returns and Variance Risk Premia

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Tauchen, George; Zhou, Hao

    constructed from high-frequency intraday, as opposed to daily, data. The magnitude of the predictability is particularly strong at the intermediate quarterly return horizon, where it dominates that afforded by other popular predictor variables, like the P/E ratio, the default spread, and the consumption...

  1. Expected Stock Returns and Variance Risk Premia

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Zhou, Hao

    risk premium with the P/E ratio results in an R2 for the quarterly returns of more than twenty-five percent. The results depend crucially on the use of "model-free", as opposed to standard Black-Scholes, implied variances, and realized variances constructed from high-frequency intraday, as opposed...

  2. Newly Homeless Youth Typically Return Home

    OpenAIRE

    Milburn, Norweeta G.; Rosenthal, Doreen; Rotheram-Borus, Mary Jane; Mallett, Shelley; Batterham, Philip; Rice, Eric; Solorio, Rosa

    2007-01-01

    165 newly homeless adolescents from Melbourne, Australia and 261 from Los Angeles, United States were surveyed and followed for two years. Most newly homeless adolescents returned home (70% U.S., 47% Australia) for significant amounts of time (39% U.S., 17% Australia more than 12 months) within two years of becoming homeless.

  3. Poor Man's Asteroid Sample Return Missions

    Science.gov (United States)

    Landis, R. R.; Graham, L. D.

    2018-02-01

    A cislunar platform at a Near-Rectilinear [Halo] Orbit in the vicinity of the Moon could provide an opportunity for a small NEA sample return mission at relatively low cost. There are a couple potential small ( 1m) object target dynamical groups.

  4. What's the Return on a Tenner Nowadays...?

    Science.gov (United States)

    Williams, Sandra

    2001-01-01

    Workplace training at the British offices of Readers' Digest is designed to improve staff skills in communicating with customers. Evaluation of workshops focused on spelling, grammar, and business writing shows that the company is achieving a return on its training investment. (SK)

  5. Male and Female Marriage Returns to Schooling

    DEFF Research Database (Denmark)

    Bruze, Gustaf

    , and the extent to which men and women sort positively on several traits in marriage. Counterfactual analysis conducted with the model, suggests that US middle aged men and women are earning in the order of 30 percent of their return to schooling through improved marital outcomes....

  6. Return to golf after spine surgery.

    Science.gov (United States)

    Abla, Adib A; Maroon, Joseph C; Lochhead, Richard; Sonntag, Volker K H; Maroon, Adara; Field, Melvin

    2011-01-01

    no published evidence indicates when patients can resume golfing after spine surgery. The objective of this study is to provide data from surveys sent to spine surgeons. a survey of North American Spine Society members was undertaken querying the suggested timing of return to golf. Of 1000 spine surgeons surveyed, 523 responded (52.3%). The timing of recommended return to golf and the reasons were questioned for college/professional athletes and avid and recreational golfers of both sexes. Responses were tallied for lumbar laminectomy, lumbar microdiscectomy, lumbar fusion, and anterior cervical discectomy with fusion. the most common recommended time for return to golf was 4-8 weeks after lumbar laminectomy and lumbar microdiscectomy, 2-3 months after anterior cervical fusion, and 6 months after lumbar fusion. The results showed a statistically significant increase in the recommended time to resume golf after lumbar fusion than after cervical fusion in all patients (p golf after spine surgery depends on many variables, including the general well-being of patients in terms of pain control and comfort when golfing. This survey serves as a guide that can assist medical practitioners in telling patients the average times recommended by surgeons across North America regarding return to golf after spine surgery.

  7. Heterogeneity of Human Capital and the Return

    DEFF Research Database (Denmark)

    Madsen, Erik Strøjer

    2015-01-01

    Human capital is an important growth factor for developing and developed countries and measuring the return to education is essential in evaluating the growth impact from human capital. Most studies use the length of education measured by the years of schooling as an indicator of human capital...

  8. The Returns to Education in Entrepreneurship

    DEFF Research Database (Denmark)

    Iversen, Jens; Malchow-Møller, Nikolaj; Sørensen, Anders

    2011-01-01

    The returns to education in self-employment are addressed in four different specifications of the relationship between log income and years of schooling. The specifications range from a standard Mincer equation with a constant percentage increase in income for an additional year of schooling...

  9. Diagnosing Febrile Illness in a Returned Traveler

    Centers for Disease Control (CDC) Podcasts

    2012-03-01

    This podcast will assist health care providers in diagnosing febrile illness in patients returning from a tropical or developing country.  Created: 3/1/2012 by National Center for Enteric, Zoonotic, and Infectious Diseases (NCEZID).   Date Released: 3/1/2012.

  10. AHP 47: WAITING FOR THE RETURN

    Directory of Open Access Journals (Sweden)

    Rdo rje skyabs རྡོ་རྗེ་སྐྱབས།

    2017-04-01

    Full Text Available "Tshe ring, how many days has your father been away?" "Father's been gone for twenty-one days," Tshe ring replied. "Oh! Twenty-one days isn't a short time. It's time for him to return. I hope he comes back safely and quickly," Tshe ring's grandmother observed, and resumed chanting and spinning her old prayer wheel. ...

  11. The returns to foreign R&D

    NARCIS (Netherlands)

    Belderbos, R.A.; Lokshin, B.; Sadowski, B.

    2015-01-01

    Extant research on R&D internationalization has not examined how effective foreign R&D investments are in generating positive returns for the investing firms, in particular in comparison and conjunction with the effects of domestic R&D investments. We examine the effectiveness of international

  12. Intergranular attack evaluation from hideout return

    International Nuclear Information System (INIS)

    Nordmann, F.; Dupin, M.; Menet, O.; Fiquet, J.-M.

    1989-01-01

    Intergranular Attack (IGA) is the secondary side corrosion mechanism on PWR steam generator tubing, which can occur most frequently even with a good waterchemistry. It has moderately developed in a few French units. Consequently, several remedies have been implemented, such as sodium content decrease in makeup water and application of more stringent chemistry specifications. In order to evaluate the local chemistry in restricted areas where IGA may occur, a large hideout return programme has been carried out on many units. It shows that free alkalinity returning during shutdown is usually ranging from 0.5 to 5 g of sodium per steam generator, and that the required time to let it return is about 40 hours. However, high temperature pH calculations indicate that such an amount of alkalinity can correspond to a potentially corrosive solution in restricted areas, where a concentration factor of 10 5 to 10 7 can be reached, inducing a pH of 10 at 300 o C. Studies are still in progress in order to define when a shutdown should be required to allow hideout return and help to prevent IGA. (author)

  13. Preoperative predictors of returning to work following primary total knee arthroplasty.

    Science.gov (United States)

    Styron, Joseph F; Barsoum, Wael K; Smyth, Kathleen A; Singer, Mendel E

    2011-01-05

    There is little in the literature to guide clinicians in advising patients regarding their return to work following a primary total knee arthroplasty. In this study, we aimed to identify which factors are important in estimating a patient's time to return to work following primary total knee arthroplasty, how long patients can anticipate being off from work, and the types of jobs to which patients are able to return following primary total knee arthroplasty. A prospective cohort study was performed in which patients scheduled for a primary total knee arthroplasty completed a validated questionnaire preoperatively and at four to six weeks, three months, and six months postoperatively. The questionnaire assessed the patient's occupational physical demands, ability to perform job responsibilities, physical status, and motivation to return to work as well as factors that may impact his or her recovery and other workplace characteristics. Two survival analysis models were constructed to evaluate the time to return to work either at least part-time or full-time. Acceleration factors were calculated to indicate the relative percentage of time until the patient returned to work. The median time to return to work was 8.9 weeks. Patients who reported a sense of urgency about returning to work were found to return in half the time taken by other employees (acceleration factor = 0.468; p mental health scores (acceleration factor = 0.891), higher physical function scores (acceleration factor = 0.809), higher Functional Comorbidity Index scores (acceleration factor = 0.914), and a handicap accessible workplace (acceleration factor = 0.736). A slower return to work was associated with having less pain preoperatively (acceleration factor = 1.132), having a more physically demanding job (acceleration factor = 1.116), and receiving Workers' Compensation (acceleration factor = 4.360). Although the physical demands of a patient's job have a moderate influence on the patient's ability

  14. 7 CFR 3560.305 - Return on investment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Return on investment. 3560.305 Section 3560.305... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Financial Management § 3560.305 Return on investment. (a) Borrower's return on investment. Borrowers may receive a return on their investment (ROI) in...

  15. 76 FR 36996 - Extension of Time for Filing Returns

    Science.gov (United States)

    2011-06-24

    ... less time to complete accurate income tax returns and to provide timely information to the trust's... either chapter 7 or chapter 11 of Title 11 of the U.S. Code that is required to file an income tax return... estate or trust income tax return or failure to pay the amount shown as tax on the return. (g) Effective...

  16. Inventory control with product returns : The impact of imperfect information

    NARCIS (Netherlands)

    De Brito, M.P.; Laan, E.A.

    2009-01-01

    Product returns are characterized by considerable uncertainty on time and quantity. In the literature on inventory management for product return environments best forecasts of future returns are associated with methods that use the most information regarding product return history. In practice,

  17. [Psychiatric Inpatient Treatment and Return to Work].

    Science.gov (United States)

    Mernyi, Lena; Hölzle, Patricia; Hamann, Johannes

    2017-05-12

    Objective People with mental diseases have a high risk of unemployment and they have only limited access to the labor market. The return to work is often associated with fears.The present study aims to provide an overview of the number of hospitalized psychiatric patients with permanent employment. Moreover it should give an insight into the process of return to work, the experiences patients gain and the support they receive. Methods In the participating clinics we measured the number of patients with permanent employment. The main inclusion criteria for further survey were the status of permanent employment and age between 18 and 65. The participating patients were interviewed on two occasions, at the time of inclusion and 3 months after the patient was discharged. The questions addressed working conditions, job satisfaction and the process of return-to-work. For statistical analysis, descriptive statistics (frequencies, means, standard deviations) were used. Results Only 21 % of n = 815 inpatients of the participating hospitals were permanently employed. Many patients did not return to work after being discharged. In many cases the interviewed patients saw a connection between their job and their current episode of illness. In this context patients reported unsatisfying workplace conditions such as long working hours, bad work organization and social conflicts. Conclusions For mentally ill patients, the employment rate in the primary labor market is devastating low. After psychiatric inpatient treatment patients are at high risk to lose their jobs. In order to prevent this development, work-related stress factors should be discussed with inpatients at an early stage and support should be provided during the return-to-work-process. © Georg Thieme Verlag KG Stuttgart · New York.

  18. Expected commodity returns and pricing models

    International Nuclear Information System (INIS)

    Cortazar, Gonzalo; Kovacevic, Ivo; Schwartz, Eduardo S.

    2015-01-01

    Stochastic models of commodity prices have evolved considerably in terms of their structure and the number and interpretation of the state variables that model the underlying risk. Using multiple factors, different specifications and modern estimation techniques, these models have gained wide acceptance because of their success in accurately fitting the observed commodity futures' term structures and their dynamics. It is not well emphasized however that these models, in addition to providing the risk neutral distribution of future spot prices, also provide their true distribution. While the parameters of the risk neutral distribution are estimated more precisely and are usually statistically significant, some of the parameters of the true distribution are typically measured with large errors and are statistically insignificant. In this paper we argue that to increase the reliability of commodity pricing models, and therefore their use by practitioners, some of their parameters — in particular the risk premium parameters — should be obtained from other sources and we show that this can be done without losing any precision in the pricing of futures contracts. We show how the risk premium parameters can be obtained from estimations of expected futures returns and provide alternative procedures for estimating these expected futures returns. - Highlights: • Simple methodology to improve the performance of commodity pricing models • New information about commodity futures expected return is added to the estimation. • No significant effect in pricing futures contracts is observed. • More reliable commodity pricing model's expected returns are obtained. • Methodology is open to any expected futures return model preferred by practitioner

  19. Efeito da disponibilidade de hospedeiro e de alimento nas características biológicas de Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae Efect of host and food availability on the biological characteristics of Trichogramma galloi Zucchi (Hymenoptera, Trichogrammatidae

    Directory of Open Access Journals (Sweden)

    Dirceu Pratissoli

    2004-03-01

    Full Text Available Características biológicas de Trichogramma galloi Zucchi, 1988 foram avaliadas em laboratório onde esses parasitóides foram criados com ovos de Diatraea saccharalis (Lepidoptera, Pyralidae, com ou sem mel, e expostos a ovos do hospedeiro após 0, 6, 12, 24, 36, 48, 60, 72 e 84 horas da emergência. As taxas de parasitismo e de viabilidade mostraram-se elevadas para indivíduos que receberam alimento. A razão sexual não foi influenciada pelo alimento. O número de indivíduos por ovo somente mostrou diferença para aqueles adultos que não receberam alimento e permaneceram 6 horas sem ovos do hospedeiro. Conferindo o efeito da disponibilidade de ovos, somente a razão sexual, com ou sem mel, não mostrou diferenças. Os resultados mostram que T. galloi necessita de um suprimento de carboidratos e que o tempo pode influenciar a capacidade reprodutiva.Biological characteristics of Trichogramma galloi Zucchi, 1988 were evaluated in laboratory where these parasitoids were reared on eggs of Diatraea saccharalis (Lepidoptera, Pyralidae with or without honey, and exposed to eggs of the host after 0, 6, 12, 24, 36, 48, 60, 72 and 84 hours of emergence. The parasitism rate and viability showed higher for individuals that received food. The sex ratio was not influenced by food. The number of individuals per egg only showed difference for those adults that did not receive food and stayed six hours without the host eggs. Checking the effect of the availability of eggs, only the sex ratio, with or without honey, did not show differences. The results show that T. galloi needs a carbohydrate supply and the time can influence the reproductive capacity.

  20. 26 CFR 301.6019-1 - Gift tax returns.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Gift tax returns. 301.6019-1 Section 301.6019-1... ADMINISTRATION PROCEDURE AND ADMINISTRATION Information and Returns Returns and Records § 301.6019-1 Gift tax returns. For provisions relating to requirement of gift tax returns, see §§ 25.6019-1 to 25.6019-4...

  1. ANALYSING TURKISH INDIVIDUAL PENSION SYSTEM FEES AND RETURNS

    OpenAIRE

    Peker, Ibrahim

    2018-01-01

    This study aims at categorizing, computing and analyzing fees and costs in Turkish Individual Pension System. To this end, net real returns after all costs were computed and these returns were compared with the disclosed fees and returns. Generally in practice, only fund management fees are taken into consideration for calculating net returns and with this method net annual average (geometric) return of the system is calculated as 2.01% for the 2008-2014 period. However, the results of this s...

  2. 26 CFR 301.6103(n)-1 - Disclosure of returns and return information in connection with written contracts or agreements...

    Science.gov (United States)

    2010-04-01

    ... administration purposes. 301.6103(n)-1 Section 301.6103(n)-1 Internal Revenue INTERNAL REVENUE SERVICE... and Returns Returns and Records § 301.6103(n)-1 Disclosure of returns and return information in... administration purposes. (a) General rule. (1) Pursuant to the provisions of section 6103(n) of the Internal...

  3. The effect that energy storage and return feet have on the propulsion of the body: a pilot study.

    Science.gov (United States)

    Crimin, Anthony; McGarry, Anthony; Harris, Elena Jane; Solomonidis, Stephan Emanuel

    2014-09-01

    A variety of energy storage and return prosthetic feet are currently available for use within lower limb prostheses. Designs claim to provide a beneficial energy return during push-off, but the extent to which this occurs remains disputed. Techniques currently used to measure energy storage, dissipation and return within the structure of the prosthetic foot are debatable, with limited evidence to support substantial elastic energy storage and return from existing designs. The aim of this study was to evaluate the performance of energy storage and return foot designs through considering the ankle power during push-off and the effect on body centre of mass propulsion. To achieve this aim, the gait patterns of six trans-tibial prosthetic users wearing different designs of energy storage and return feet were analysed while ascending a ramp. Three examples of energy storage and return feet (suitable for moderate activity) were selected and randomly evaluated: the Blatchford's Epirus, Össur Assure and College Park Tribute feet. The power at the anatomical and mechanical ankle joints was integrated to evaluate the work done over the gait cycle. The direction of the inertial force, and therefore propulsion of the body centre of mass, was used to indicate the effect of the energy return by the energy storage and return feet. Results indicate that although energy storage and return feet may provide energy return, the work done around the prosthetic ankle indicates net power absorption. Therefore, the prosthetic limb is unable to contribute to the body centre of mass propulsion to the same extent as the biological limb. © IMechE 2014.

  4. A systematic review of studies identifying predictors of poor return to work outcomes following workplace injury.

    Science.gov (United States)

    Street, Tamara D; Lacey, Sarah J

    2015-06-05

    Injuries occurring in the workplace can have serious implications for the health of the individual, the productivity of the employer and the overall economic community. The objective of this paper is to increase the current state of understanding of individual demographic and psychosocial characteristics associated with extended absenteeism from the workforce due to a workplace injury. Studies included in this systematic literature review tracked participants' return to work status over a minimum of three months, identified either demographic, psychosocial or general injury predictors of poor return to work outcomes and included a heterogeneous sample of workplace injuries. Identified predictors of poor return to work outcomes included older age, female gender, divorced marital status, two or more dependent family members, lower education levels, employment variables associated with reduced labour market desirability, severity or sensitive injury locations, negative attitudes and outcome perceptions of the participant. There is a need for clear and consistent definition and measurement of return to work outcomes and a holistic theoretical model integrating injury, psychosocial and demographic predictors of return to work. Through greater understanding of the nature of factors affecting return to work, improved outcomes could be achieved.

  5. Returns management in the supply chain

    Directory of Open Access Journals (Sweden)

    Anna Maria Jeszka

    2014-09-01

    Full Text Available Background:  The aim of this exploratory empirical research was to evaluate the level of cooperation in the area of reverse logistics between selected retail chains and logistics operators and suppliers; to identify and evaluate the influence the procedures of handling returns have on the relationships with customers, cost reduction, value recovery, inventory reduction and increasing profitability; as well as determining to what extent logistics operators are involved in the procedures of handling returns in the analysed chains. Methods: Based on the literature and the experience of researchers from developed countries a questionnaire was constructed which was subsequently used to conduct empirical research in selected retail chains operating in two provinces in Poland. The questionnaire survey involved the sales personnel of selected retail chains in the clothing industry. Overall, 105 questionnaires were collected and analysed. Results: Various aspects of cooperation with suppliers and logistics operators in respect of handling returns were evaluated. Most indicators of cooperation were evaluated favourably, with the exception of joint access to the database, the use of inventory data available online, and access to information from the warehouse, which received low marks from the respondents. In the case of the studied stores, some of the activities in the area of reverse logistics are outsourced; for example, obtaining products from users, logistics, and the transport of returns are typically done by an outside operator. Inspection, sorting, appraisal, repairs, as well as the sales of refurbished products are usually performed within the studied retail corporations. Conclusions: The research has shown that the retail chains developed very good programmes for handling returns in the supply chain, as evidenced by the presented and highly rated indicators of cooperation, with the exception of information exchange where there is still much

  6. The Relationship between Market Sentiment Index and Stock Rates of Return: a Panel Data Analysis

    Directory of Open Access Journals (Sweden)

    Claudia Emiko Yoshinaga

    2012-04-01

    Full Text Available This article analyzes the relationship between market sentiment and future stock rates of return. We used amethodology based on principal component analysis to create a sentiment index for the Brazilian market withdata from 1999 to 2008. The sample consisted of companies listed on BM&FBOVESPA which were groupedinto quintiles, each representing a portfolio, according to the magnitude of the following characteristics: marketvalue, total annualized risk and listing time on BM&FBOVESPA. Next, we calculated the average return of eachportfolio for every quarter. The data for the first and last quintiles were analyzed via two-factor ANOVA, usingsentiment index of the previous period (positive or negative as the main factor and each characteristic ascontrolling factors. Finally, the sentiment index was included in a panel data pricing model. The results indicatea significant and negative relationship between the market sentiment index and the future rates of return. Thesefindings suggest the existence of a reversion pattern in stock returns, meaning that after a positive sentimentperiod, the impact on subsequent stock returns is negative, and vice-versa.

  7. [Biological agents].

    Science.gov (United States)

    Amano, Koichi

    2009-03-01

    There are two types of biological agents for the treatment of rheumatoid arthritis (RA); monoclonal antibodies and recombinant proteins. Among the latter, etanercept, a recombinant fusion protein of soluble TNF receptor and IgG was approved in 2005 in Japan. The post-marketing surveillance of 13,894 RA patients revealed the efficacy and safety profiles of etanercept in the Japanese population, as well as overseas studies. Abatacept, a recombinant fusion protein of CTLA4 and IgG, is another biological agent for RA. Two clinical trials disclosed the efficacy of abatacept for difficult-to-treat patients: the AIM for MTX-resistant cases and the ATTAIN for patients who are resistant to anti-TNF. The ATTEST trial suggested abatacept might have more acceptable safety profile than infliximab. These biologics are also promising for the treatment of RA for not only relieving clinical symptoms and signs but retarding structural damage.

  8. Biological preconcentrator

    Science.gov (United States)

    Manginell, Ronald P [Albuquerque, NM; Bunker, Bruce C [Albuquerque, NM; Huber, Dale L [Albuquerque, NM

    2008-09-09

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  9. Paradigms for biologically inspired design

    DEFF Research Database (Denmark)

    Lenau, T. A.; Metzea, A.-L.; Hesselberg, T.

    2018-01-01

    engineering, medical engineering, nanotechnology, photonics,environmental protection and agriculture. However, a major obstacle for the wider use of biologically inspired design isthe knowledge barrier that exist between the application engineers that have insight into how to design suitable productsand......Biologically inspired design is attracting increasing interest since it offers access to a huge biological repository of wellproven design principles that can be used for developing new and innovative products. Biological phenomena can inspireproduct innovation in as diverse areas as mechanical...... the biologists with detailed knowledge and experience in understanding how biological organisms function in theirenvironment. The biologically inspired design process can therefore be approached using different design paradigmsdepending on the dominant opportunities, challenges and knowledge characteristics...

  10. Fundamental volatility and stock returns : does fundamental volatility explain stock returns?

    OpenAIRE

    Selboe, Guner K.; Virdee, Jaspal Singh

    2017-01-01

    In this thesis, we investigate whether the fundamental uncertainty can explain the crosssection of stock returns. To measure the fundamental uncertainty, we estimate rolling standard deviations and accounting betas of four different fundamentals: revenues, gross profit, earnings and cash flows. The standard deviation and the beta of revenues significantly explain returns in the Fama-Macbeth procedure, but only appears significant among smaller stocks in the portfolio formation ...

  11. Who Has the Advantage? Race and Sex Differences in Returns to Social Capital at Home and at School*

    Science.gov (United States)

    Dufur, Mikaela J.; Parcel, Toby L.; Hoffmann, John P.; Braudt, David B.

    2016-01-01

    A growing body of literature suggests that social capital is a valuable resource for children and youth, and that returns to that capital can increase academic success. However, relatively little is known about whether youth from different backgrounds build social capital in the same way and whether they receive the same returns to that capital. We examine the creation of and returns to social capital in family and school settings on academic achievement, measured as standardized test scores, for white boys, black boys, white girls, and black girls who were seniors in high school in the United States. Our findings suggest that while youth in different groups build social capital in largely the same way, differences exist by race and sex as to how family social capital affects academic achievement. Girls obtain greater returns to family social capital than do boys, but no group receives significant returns to school social capital after controlling for individual- and school-level characteristics. PMID:27594731

  12. Return to work and workplace activity limitations following total hip or knee replacement.

    Science.gov (United States)

    Sankar, A; Davis, A M; Palaganas, M P; Beaton, D E; Badley, E M; Gignac, M A

    2013-10-01

    Total hip (THR) and knee (TKR) replacements increasingly are performed on younger people making return to work a salient outcome. This research evaluates characteristics of individuals with early and later return to work following THR and TKR. Additionally, at work limitations pre-surgery and upon returning to work, and factors associated with work limitations were evaluated. 190 THR and 170 TKR of a total 931 cohort participants were eligible (i.e., working or on short-term disability pre-surgery). They completed questionnaires pre-surgery and 1, 3, 6 and 12 months post-surgery that included demographics, type of occupation, and the Workplace Activity Limitations Scale (WALS). 166 (87%) and 144 (85%) returned to work by 12 months following THR and TKR, respectively. Early (1 month) return to work was associated with, male gender, university education, working in business, finance or administration, and low physical demand work. People with THR returned to work earlier than those with TKR. For both groups, less pain and every day functional limitations were associated with less workplace activity limitations at the time return to work. The majority of individuals working prior to surgery return to work following hip or knee replacement for osteoarthritis (OA) and experience fewer limitations at work than pre-surgery. The changing workforce dynamics and trends toward surgery at younger ages mean that these are important outcomes for clinicians to assess. Additionally, this is important information for employers in understanding continued participation in employment for people with OA. Copyright © 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  13. Margin Requirements and Equity Option Returns

    DEFF Research Database (Denmark)

    Hitzemann, Steffen; Hofmann, Michael; Uhrig-Homburg, Marliese

    In equity option markets, traders face margin requirements both for the options themselves and for hedging-related positions in the underlying stock market. We show that these requirements carry a significant margin premium in the cross-section of equity option returns. The sign of the margin...... premium depends on demand pressure: If end-users are on the long side of the market, option returns decrease with margins, while they increase otherwise. Our results are statistically and economically significant and robust to different margin specifications and various control variables. We explain our...... findings by a model of funding-constrained derivatives dealers that require compensation for satisfying end-users’ option demand....

  14. Margin Requirements and Equity Option Returns

    DEFF Research Database (Denmark)

    Hitzemann, Steffen; Hofmann, Michael; Uhrig-Homburg, Marliese

    In equity option markets, traders face margin requirements both for the options themselves and for hedging-related positions in the underlying stock market. We show that these requirements carry a significant "margin premium" in the cross-section of equity option returns. The sign of the margin...... premium depends on demand pressure: If end-users are on the long side of the market, option returns decrease with margins, while they increase otherwise. Our results are statistically and economically significant and robust to different margin specifications and various control variables. We explain our...... findings by a model of funding-constrained derivatives dealers that require compensation for satisfying end-users’ option demand....

  15. Effective return, risk aversion and drawdowns

    Science.gov (United States)

    Dacorogna, Michel M.; Gençay, Ramazan; Müller, Ulrich A.; Pictet, Olivier V.

    2001-01-01

    We derive two risk-adjusted performance measures for investors with risk averse preferences. Maximizing these measures is equivalent to maximizing the expected utility of an investor. The first measure, Xeff, is derived assuming a constant risk aversion while the second measure, Reff, is based on a stronger risk aversion to clustering of losses than of gains. The clustering of returns is captured through a multi-horizon framework. The empirical properties of Xeff, Reff are studied within the context of real-time trading models for foreign exchange rates and their properties are compared to those of more traditional measures like the annualized return, the Sharpe Ratio and the maximum drawdown. Our measures are shown to be more robust against clustering of losses and have the ability to fully characterize the dynamic behaviour of investment strategies.

  16. Idleness, returns to education and child labor

    Directory of Open Access Journals (Sweden)

    José Raimundo Carvalho

    2012-12-01

    Full Text Available Although recent trends about child labor are positive, see ILO (2006, there still are important shortcomings which require further investigation. Among them, the exclusion of the category "idle children" (those who neither work nor study from past studies, as well as the lack of reliable information on returns to education are two significant omissions. By using a data base that contains details on idle children and a proxy for the returns to education, we find evidence that confirms traditional findings both with regard to the strong positive effect of parental background and to the positive relationship between the number of children in the household and child labor. On the other hand, our estimates point out new insights, such as the great regional variation of estimates and the fact that the Body Mass Index effect is positive. Finally, we suggest a new perspective on the issue of "street children" through the analysis of the category of "idle children".

  17. Country Fundamentals and Currency Excess Returns

    Directory of Open Access Journals (Sweden)

    Daehwan Kim

    2014-06-01

    Full Text Available We examine whether country fundamentals help explain the cross-section of currency excess returns. For this purpose, we consider fundamental variables such as default risk, foreign exchange rate regime, capital control as well as interest rate in the multi-factor model framework. Our empirical results show that fundamental factors explain a large part of the cross-section of currency excess returns. The zero-intercept restriction of the factor model is not rejected for most currencies. They also reveal that our factor model with country fundamentals performs better than a factor model with usual investment-style factors. Our main empirical results are based on 2001-2010 balanced panel data of 19 major currencies. This paper may fill the gap between country fundamentals and practitioners' strategies on currency investment.

  18. Integrating Remote Sensing and Citizen Science to Study the Environmental Context and Ecological Consequences of Returning Avian Predators

    Science.gov (United States)

    Zuckerberg, B.; McCabe, J.; Yin, H.; Pidgeon, A. M.; Bonter, D. N.; Radeloff, V.

    2017-12-01

    Urbanization causes the simplification of animal communities dominated by exotic and invasive species with few top predators. In recent years, however, many animal predators (e.g., coyotes, cougars, and hawks) have become increasingly common in urban environments. As predator recovery is central to the mission of conservation biology, this colonization of urban environments represents a unique experiment in predator colonization and its associated ecological consequences. One such predator that is recovering from decades of widespread population declines are accipiter hawks. These woodland hawks are widely distributed throughout North America and are increasingly common in urban and suburban landscapes. Using data from Project FeederWatch, a national citizen science program, we quantified 25 years (1990-2015) of changes in the spatiotemporal dynamics of accipiter hawks in Washington D.C. and Chicago. We estimated change in hawk occupancy over time and identified the environmental characteristics associated with occupancy for two accipiter hawk species, Cooper's Hawk (Accipiter cooperii) and Sharp-shinned Hawk (Accipiter striatus), using Bayesian hierarchical models and remotely-sensed temperature (MODIS) and land cover data (NLCD). We found the proportion of sites recording the presence of accipiter hawks increased from 10% in the early 1990's to over 80% in 2015. This increase in occupancy followed a discrete pattern of establishment, growth, and saturation. Colonizing hawks were more strongly associated with remnant forest patches in urban environments. Over time, we found hawks became more tolerant of urban landscapes with higher amounts of impervious surface, suggesting that these predators became adapted to urbanization. The implications of returning predators and altered ecological dynamics in urban environments is of critical importance to conservation biology, and integrating remote sensing observations and citizen science allowed for an unprecedented

  19. Restaurant customer satisfaction and return patronage in a Bloemfontein shopping mall

    Directory of Open Access Journals (Sweden)

    Hermanus Johannes Moolman

    2011-12-01

    Full Text Available Purpose: Restaurants form one of the core components of a mall's retail offering and its tenant mix. In order to successfully manage the tenant mix, research suggests that mall management continuously monitor their tenants' performance through customer satisfaction and return patronage surveys. The purpose of the study on which this article is based, was to gain insight into restaurant customers' satisfaction and return patronage in a shopping mall context. Research questions: The research was conceptualised with the following three research questions in mind: Which dining attributes are important for customer satisfaction and return patronage in mall restaurants? Is there a difference in restaurant customers' satisfaction and return patronage levels based on their demographic characteristics? Is there a difference in restaurant customers' satisfaction and return patronage in the respective mall restaurants? Design / methodology / approach: A mixed-methods research design was followed. The views of restaurateurs and mall managers were explored (qualitative and 590 customers of eight restaurants situated in the mall successfully completed questionnaires (quantitative. Analysis of variance, t-tests, correlation analysis and regression analysis were performed to reach the objectives of the study. Findings: This research showed that food quality, quality service, restaurant ambience, the quality of facilities and the presence of management are important attributes in contributing to customers' overall dining satisfaction. Food quality and overall dining satisfaction are regarded as important attributes for restaurant customers' decision to return to a mall restaurant. Demographic characteristics of restaurant customers have little impact on customer satisfaction and return patronage levels. Mall restaurants were not equally successful in satisfying their customers in terms of service quality, quality of facilities and the presence of management

  20. Returns management in the supply chain

    OpenAIRE

    Anna Maria Jeszka

    2014-01-01

    Background:  The aim of this exploratory empirical research was to evaluate the level of cooperation in the area of reverse logistics between selected retail chains and logistics operators and suppliers; to identify and evaluate the influence the procedures of handling returns have on the relationships with customers, cost reduction, value recovery, inventory reduction and increasing profitability; as well as determining to what extent logistics operators are involved in the procedures o...

  1. Mars Sample Return Using Solar Sail Propulsion

    Science.gov (United States)

    Johnson, Les; Macdonald, Malcolm; Mcinnes, Colin; Percy, Tom

    2012-01-01

    Many Mars Sample Return (MSR) architecture studies have been conducted over the years. A key element of them is the Earth Return Stage (ERS) whose objective is to obtain the sample from the Mars Ascent Vehicle (MAV) and return it safely to the surface of the Earth. ERS designs predominantly use chemical propulsion [1], incurring a significant launch mass penalty due to the low specific impulse of such systems coupled with the launch mass sensitivity to returned mass. It is proposed to use solar sail propulsion for the ERS, providing a high (effective) specific impulse propulsion system in the final stage of the multi-stage system. By doing so to the launch mass of the orbiter mission can be significantly reduced and hence potentially decreasing mission cost. Further, solar sailing offers a unique set of non-Keplerian low thrust trajectories that may enable modifications to the current approach to designing the Earth Entry Vehicle by potentially reducing the Earth arrival velocity. This modification will further decrease the mass of the orbiter system. Solar sail propulsion uses sunlight to propel vehicles through space by reflecting solar photons from a large, mirror-like surface made of a lightweight, reflective material. The continuous photonic pressure provides propellantless thrust to conduct orbital maneuvering and plane changes more efficiently than conventional chemical propulsion. Because the Sun supplies the necessary propulsive energy, solar sails require no onboard propellant, thus reducing system mass. This technology is currently at TRL 7/8 as demonstrated by the 2010 flight of the Japanese Aerospace Exploration Agency, JAXA, IKAROS mission. [2

  2. Where Are the Returns to Lifelong Learning?

    OpenAIRE

    Coelli, Michael; Tabasso, Domenico

    2015-01-01

    We investigate the labour market determinants and outcomes of adult participation in formal education (lifelong learning) in Australia, a country with high levels of adult education. Employing longitudinal data and fixed effects methods allows identification of effects on outcomes free of ability bias. Different trends in outcomes across groups are also allowed for. The impacts of adult education differ by gender and level of study, with small or zero labour market returns in many cases. Wage...

  3. Returns to Tenure: Time or Rank?

    DEFF Research Database (Denmark)

    Buhai, Ioan Sebastian

    -specific investment, efficiency-wages or adverse-selection models. However, rent extracting arguments as suggested by the theory of internal labor markets, indicate that the relative position of the worker in the seniority hierarchy of the firm, her 'seniority rank', may also explain part of the observed returns...... relative to their peer workers), as predicted by theories on unionized and insider-outsider markets....

  4. The survival and return of institutions

    DEFF Research Database (Denmark)

    Guardiancich, Igor

    2011-01-01

    Opening a new phase in historical institutionalism, Wolfgang Streeck and Kathleen Thelen show how a rigid dichotomy between incremental adaptation and radical transformation fails to capture important transformative processes common to advanced political economies. While their research focuses...... on gradual but radical transformation, the two authors leave open the interpretation of what constitutes abrupt, but only limited change. This article integrates their framework, defines what they call survival and return, and, within this genus, indicates two analytically distinct species: replication...

  5. Macroeconomic Forces and Stock Returns in Vietnam

    OpenAIRE

    Phan, Van Hang

    2008-01-01

    Capital market development, especially the appearance of Vietnamese equity market recently has a strategic importance in the economic growth and structural reform process of Vietnam (Chun et al, 2003). This dissertation focuses on the impacts of macroeconomic forces on stock market returns in Vietnamese stock market which has not been investigated in detail before, and thereby to contribute further literature on this new emerging stock market. Specifically, the research will intensively inves...

  6. An Analysis of Theories on Stock Returns

    Directory of Open Access Journals (Sweden)

    Ahmet Sekreter

    2017-03-01

    Full Text Available Objective in writing this article is to provide an overview of the theories that has been developed for stock returns which is an important area of financial markets’ researches. Since the researches in this field are very active for the past quarter, it is not possible to describe all works that has been done in this area. Most important researches will be discussed without going deeper in mathematical tools and theories.

  7. Management of the returning traveler with diarrhea.

    Science.gov (United States)

    de Saussure, Philippe P H

    2009-11-01

    Traveler's diarrhea (TD) strikes 20-60% of travelers visiting developing countries. It occurs shortly after the return and can be distinguished into two categories: acute and persistent TD. Acute TD, mostly caused by bacterial and viral pathogens, is usually mild and self-limited, and deserves empirical symptomatic and/or antibiotic therapy in selected cases. Fluoroquinolones are progressively superseded in this indication by azithromycin, a well tolerated macrolide active against most bacteria responsible for TD, including the quinolone-resistant species of Campylobacter jejuni that are now pervasive, especially in Southeast Asia and India. Persistent TD in the returning traveler is much rarer than its acute counterpart and may be associated with three types of causes. Persistent infections, among which Giardia and possibly Entamoeba predominate, account for a significant proportion of cases. Postinfectious processes represent a second cause and comprise temporary lactose malabsorption and postinfectious irritable bowel syndrome, now considered a major cause of persistent TD. Finally, apparently unrelated chronic diseases causing diarrhea are occasionally unmasked by TD and represent a third type of persistent TD, among which the well established case of incident inflammatory bowel disease poses intriguing pathogenesis questions. This review discusses recent advances in the field and provides practical recommendations for the management of TD in adult, immunocompetent returning travelers.

  8. Earnings Quality Measures and Excess Returns.

    Science.gov (United States)

    Perotti, Pietro; Wagenhofer, Alfred

    2014-06-01

    This paper examines how commonly used earnings quality measures fulfill a key objective of financial reporting, i.e., improving decision usefulness for investors. We propose a stock-price-based measure for assessing the quality of earnings quality measures. We predict that firms with higher earnings quality will be less mispriced than other firms. Mispricing is measured by the difference of the mean absolute excess returns of portfolios formed on high and low values of a measure. We examine persistence, predictability, two measures of smoothness, abnormal accruals, accruals quality, earnings response coefficient and value relevance. For a large sample of US non-financial firms over the period 1988-2007, we show that all measures except for smoothness are negatively associated with absolute excess returns, suggesting that smoothness is generally a favorable attribute of earnings. Accruals measures generate the largest spread in absolute excess returns, followed by smoothness and market-based measures. These results lend support to the widespread use of accruals measures as overall measures of earnings quality in the literature.

  9. Return to play after infectious mononucleosis.

    Science.gov (United States)

    Becker, Jonathan A; Smith, Julie Anne

    2014-05-01

    Infectious mononucleosis is a disease primarily of adolescence and early adulthood. The risk of splenic injury and chronic fatigue make return-to-play decisions a challenge for the clinician caring for athletes with infectious mononucleosis. Data were obtained from the PubMed and MEDLINE databases through December 2012 by searching for epidemiology, diagnosis, clinical manifestations, management, and the role of the spleen in infectious mononucleosis. Clinical review. Level 4. Infectious mononucleosis is commonly encountered in young athletes. Its disease pattern is variable and can affect multiple organ systems. Supportive care is the cornerstone, with little role for medications such as corticosteroids. Physical examination is unreliable for the spleen, and ultrasound imaging has limitations in its ability to guide return-to-play decisions. Exercise does not appear to place the young athlete at risk for chronic fatigue, but determining who is at risk for persistent symptoms is a challenge. Return-to-play decisions for the athlete with infectious mononucleosis need to be individualized because of the variable disease course and lack of evidence-based guidelines.

  10. Allan deviation analysis of financial return series

    Science.gov (United States)

    Hernández-Pérez, R.

    2012-05-01

    We perform a scaling analysis for the return series of different financial assets applying the Allan deviation (ADEV), which is used in the time and frequency metrology to characterize quantitatively the stability of frequency standards since it has demonstrated to be a robust quantity to analyze fluctuations of non-stationary time series for different observation intervals. The data used are opening price daily series for assets from different markets during a time span of around ten years. We found that the ADEV results for the return series at short scales resemble those expected for an uncorrelated series, consistent with the efficient market hypothesis. On the other hand, the ADEV results for absolute return series for short scales (first one or two decades) decrease following approximately a scaling relation up to a point that is different for almost each asset, after which the ADEV deviates from scaling, which suggests that the presence of clustering, long-range dependence and non-stationarity signatures in the series drive the results for large observation intervals.

  11. Stakeholder views on returning research results.

    Science.gov (United States)

    Haga, Susanne B; Zhao, Jennifer Q

    2013-01-01

    While the disclosure of research findings is relevant to all types of biomedical research, it has garnered particular attention with respect to genetics and genomics research due to some of the unique aspects of the data and the high public profile of the field. In this chapter, we review the attitudes of stakeholders (research participants, policymakers, and researchers) to define areas of consensus regarding the issue of returning research results across and within groups. In addition to stakeholder attitudes about obligations and interest in research results, other major related issues related to returning research results, such as informed consent, communication of research results, and cost, are discussed. Given the consensus between stakeholders to return summary reports of a study's outcomes and individual research results of clinical significance, we conclude that the time has come to encourage, if not require, researchers to consider these issues in the developmental planning stages of a project and to plan and budget accordingly. © 2013 Elsevier Inc. All rights reserved.

  12. The experience of returning to work.

    Science.gov (United States)

    Jansson, Inger; Björklund, Anita

    2007-01-01

    The purpose of this qualitative study was to explore from an environmental perspective the experiences of returning to work of former unemployed sickness absentees. Five separate focus-group interviews were carried out with themes concerning different environmental areas. The findings showed that the participants in their process of being off work and then attempting returning to work experienced a personal transition manifesting itself as a negative self-image, change of life-rhythm and restrictions in their roles and activities. In their progression, the participants experienced a need for reorientation and expressed feelings of alienation, and for that reason felt need of support from a network, especially a professional one. Regarding attitudes in society, the participants reported experiences of social stigmatization, both in mass media and in their immediate social environment, and an increasing egocentricity among their fellow-workers. They perceived their progression back to work as a 'time quarantine' and as a long and destructive wait for support. The findings indicate that the phenomenon of 'returning to work' after unemployment and sick leave could not be reduced to a single issue. It should rather be seen as a dynamic problem with individual and structural, environmental aspects.

  13. Environmental biology

    International Nuclear Information System (INIS)

    Tschumi, P.A.

    1981-01-01

    Environmental biology illustrates the functioning of ecosystems and the dynamics of populations with many examples from limnology and terrestrial ecology. On this basis, present environmental problems are analyzed. The present environmental crisis is seen as a result of the failure to observe ecological laws. (orig.) [de

  14. Biological timekeeping

    DEFF Research Database (Denmark)

    Lloyd, David

    2016-01-01

    , the networks that connect differenttime domains and the oscillations, rhythms and biological clocks that coordinate andsynchronise the complexity of the living state.“It is the pattern maintained by this homeostasis, which is the touchstone ofour personal identity. Our tissues change as we live: the food we...

  15. Biological digestion

    International Nuclear Information System (INIS)

    Rosevear, A.

    1988-01-01

    This paper discusses the biological degradation of non-radioactive organic material occurring in radioactive wastes. The biochemical steps are often performed using microbes or isolated enzymes in combination with chemical steps and the aim is to oxidise the carbon, hydrogen, nitrogen and sulphur to their respective oxides. (U.K.)

  16. Marine Biology

    Science.gov (United States)

    Dewees, Christopher M.; Hooper, Jon K.

    1976-01-01

    A variety of informational material for a course in marine biology or oceanology at the secondary level is presented. Among the topics discussed are: food webs and pyramids, planktonic blooms, marine life, plankton nets, food chains, phytoplankton, zooplankton, larval plankton and filter feeders. (BT)

  17. [Analysis of posttraumatic stress disorders in Polish soldiers who returned from stabilization mission in Iraq].

    Science.gov (United States)

    Skotnicka, Justyna

    2013-01-01

    The aim of the survey was to establish whether PTSD is present among Polish soldiers returning from a one-year deployment to Iraq and an analysis of its individual symptoms. Sixty soldiers were examined, including 30 who returned from the Iraqi mission and 30 who remained in Poland. Five analysing devices were used: (IPSA), (STAI), (BDI), a PTSD questionnaire and a socio-demographical form. A significant number of soldiers experienced a traumatic event during the mission in Iraq. Although the Iraq deployment did not change the level of depression and anxiety among the two groups of soldiers, disproportions were found in the range of anger level intensity, which was significantly higher among soldiers who returned from Iraq. Stabilisation mission and the experience of a traumatic event influenced the biological and psychological functioning patterns among soldiers who returned from Iraq. The manifestations of this were emotional and physiological reactions that the soldiers experienced (nightmares, excessive sweating, increased heartbeat rate, stressful reactions in situations similar to the traumatic occurrence and intensified responses to them). However, contrary to the assumptions, it was not concluded that soldiers who returned from Iraq are suffering from PTSD.

  18. Can we enhance the ability to return to work among workers with stress-related disorders?

    DEFF Research Database (Denmark)

    Lander, Flemming; Friche, Claus; Tornemand, Helle

    2009-01-01

    counselling e.g. on decisions concerning resumption of work, support to families, participation in meetings with the workplace. Basically, the controls and the intervention group share the same access to welfare benefits. The main outcome was time to return to labour market (TTR). RESULTS: The baseline...... characteristics were similar in the two groups. There were no differences in the rate of resuming work between the two groups. About 80% in both groups had returned to the labour market after one year. CONCLUSION: An intervention program with psychological stress management and case management did not improve...

  19. Medical returns: seeking health care in Mexico.

    Science.gov (United States)

    Horton, Sarah; Cole, Stephanie

    2011-06-01

    Despite the growing prevalence of transnational medical travel among immigrant groups in industrialized nations, relatively little scholarship has explored the diverse reasons immigrants return home for care. To date, most research suggests that cost, lack of insurance and convenience propel US Latinos to seek health care along the Mexican border. Yet medical returns are common even among Latinos who do have health insurance and even among those not residing close to the border. This suggests that the distinct culture of medicine as practiced in the border clinics Latinos visit may be as important a factor in influencing medical returns as convenience and cost. Drawing upon qualitative interviews, this article presents an emic account of Latinos' perceptions of the features of medical practice in Mexico that make medical returns attractive. Between November 15, 2009 and January 15, 2010, we conducted qualitative interviews with 15 Mexican immigrants and nine Mexican Americans who sought care at Border Hospital, a private clinic in Tijuana. Sixteen were uninsured and eight had insurance. Yet of the 16 uninsured, six had purposefully dropped their insurance to make this clinic their permanent "medical home." Moreover, those who substituted receiving care at Border Hospital for their US health insurance plan did so not only because of cost, but also because of what they perceived as the distinctive style of medical practice at Border Hospital. Interviewees mentioned the rapidity of services, personal attention, effective medications, and emphasis on clinical discretion as features distinguishing "Mexican medical practice," opposing these features to the frequent referrals and tests, impersonal doctor-patient relationships, uniform treatment protocols and reliance on surgeries they experienced in the US health care system. While interviewees portrayed these features as characterizing a uniform "Mexican medical culture," we suggest that they are best described as

  20. Does Aggregated Returns Disclosure Increase Portfolio Risk Taking?

    Science.gov (United States)

    Beshears, John; Choi, James J.; Laibson, David; Madrian, Brigitte C.

    2016-01-01

    Many experiments have found that participants take more investment risk if they see returns less frequently, see portfolio-level returns (rather than each individual asset’s returns), or see long-horizon (rather than one-year) historical return distributions. In contrast, we find that such information aggregation treatments do not affect total equity investment when we make the investment environment more realistic than in prior experiments. Previously documented aggregation effects are not robust to changes in the risky asset’s return distribution or the introduction of a multi-day delay between portfolio choice and return realizations. PMID:28553012

  1. Does Aggregated Returns Disclosure Increase Portfolio Risk Taking?

    Science.gov (United States)

    Beshears, John; Choi, James J; Laibson, David; Madrian, Brigitte C

    2017-06-01

    Many experiments have found that participants take more investment risk if they see returns less frequently, see portfolio-level returns (rather than each individual asset's returns), or see long-horizon (rather than one-year) historical return distributions. In contrast, we find that such information aggregation treatments do not affect total equity investment when we make the investment environment more realistic than in prior experiments. Previously documented aggregation effects are not robust to changes in the risky asset's return distribution or the introduction of a multi-day delay between portfolio choice and return realizations.

  2. The use of a rubble chimney for denitrification of irrigation return waters

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Roy B; Kruger, Paul [Civil Engineering Department, Stanford University (United States)

    1970-05-15

    Biological denitrification has been proposed as a means of removing nitrates from waste waters to control eutrophication in receiving waters. A potential use for this method is the treatment of irrigation return waters containing high concentrations of nitrate-nitrogen, since direct discharge of such wastes may cause objectionable algal growth in the receiving waters. For example, the process may be used to treat agricultural waste waters in the San Joaquin Valley in California, where an estimated 580,000 acre-feet/year of return waters, containing 20 mg/l of nitrate-nitrogen, will require disposal by A.D. 2020. Two methods of biological denitrification are presently under study for possible use in the San Joaquin Valley. In one method nitrates are reduced to nitrogen gas by bacterial action in deep ponds; in the other method bacterial denitrification takes place in biological filters. In biological filters, bacteria are grown on columns of submerged stones. A possible alternative to the conventional construction of these filters is the creation of a rubble chimney by a contained nuclear explosion. This paper presents the results of a preliminary investigation of the feasibility of using a rubble chimney as a biological filter for denitrification. (author)

  3. The use of a rubble chimney for denitrification of irrigation return waters

    International Nuclear Information System (INIS)

    Evans, Roy B.; Kruger, Paul

    1970-01-01

    Biological denitrification has been proposed as a means of removing nitrates from waste waters to control eutrophication in receiving waters. A potential use for this method is the treatment of irrigation return waters containing high concentrations of nitrate-nitrogen, since direct discharge of such wastes may cause objectionable algal growth in the receiving waters. For example, the process may be used to treat agricultural waste waters in the San Joaquin Valley in California, where an estimated 580,000 acre-feet/year of return waters, containing 20 mg/l of nitrate-nitrogen, will require disposal by A.D. 2020. Two methods of biological denitrification are presently under study for possible use in the San Joaquin Valley. In one method nitrates are reduced to nitrogen gas by bacterial action in deep ponds; in the other method bacterial denitrification takes place in biological filters. In biological filters, bacteria are grown on columns of submerged stones. A possible alternative to the conventional construction of these filters is the creation of a rubble chimney by a contained nuclear explosion. This paper presents the results of a preliminary investigation of the feasibility of using a rubble chimney as a biological filter for denitrification. (author)

  4. Características biológicas de linhagens de Trichogramma pretiosum, criados em ovos de Sitotroga cerealella e Anagasta kuehniella Biological characteristics of Trichogramma pretiosum lineages, reared in Anagasta kuehniella and Sitotroga cerealella eggs

    Directory of Open Access Journals (Sweden)

    Dirceu Pratissoli

    2004-09-01

    Full Text Available Avaliaram-se as características biológicas de cinco linhagens de T. pretiosum Riley (Hym.:Trichogrammatidae, coletadas em plantios comerciais de tomate, e criados em ovos de A. kuehniella (Zeller e S. cerealella (Olivier. A taxa de parasitismo das cinco linhagens variou de 56,1 a 68,6%, quando o hospedeiro foi A. kuehniella, sendo superior à do hospedeiro S. cerealella. A viabilidade de todas as linhagens, quando criadas em ovos de S. cerealella, foi superior a 90%; no entanto, somente nas linhagens provenientes de Afonso Cláudio e Venda Nova do Imigrante é que a viabilidade das linhagens de Trichogramma criadas em ovos de S. cerealella, foram significativamente maiores que as criadas sobre A. kuehniella. A longevidade dos descendentes submetidos ao parasitismo foi superior para todas as linhagens quando criadas em ovos de A. kuehniella. Ambos os hospedeiros podem ser empregados na criação massal das cinco linhagens estudadas. Contudo, tomando-se por base a taxa de parasitismo e a qualidade da progênie, o hospedeiro A. kuehniella demonstrou ser superior a S. cerealella.The biological characteristics of five lineages of T. pretiosum Riley (Hym.: Trichogrammatidae, collected from tomato crops, and reared in A. kuehniella (Zeller and S. cerealella (Olivier eggs were evaluated. The parasitism rate of the lineages, varied from 56,1 to 68.6%, when the host was A. kuehniella, being higher than for S. cerealella. The viability of all lineages, when reared in S. cerealella eggs, was superior to 90%; however, only those lineages reared in S. cerealella eggs and collected in Afonso Cláudio and Venda Nova dos Imigrantes (Espirito Santo State, Brazil were significantly higher than those reared on A. kuehniella. The longevity of the offspring submitted to the parasitism, was higher in all the lineages reared in A. kuehniella eggs. All five lineages can be mass reared using both hosts. However, considering the parasitism rate and the quality of the

  5. [LincRNA-ROR functions as a ceRNA to regulate Oct4, Sox2, and Nanog expression by sponging miR-145 and its effect on biologic characteristics of colonic cancer stem cells].

    Science.gov (United States)

    Yan, Z Y; Sun, X C

    2018-04-08

    Objective: To investigate the impact of lincRNA-ROR, a ceRNA by binding miR-145 on the expression of the downstream genes Oct4, Sox2 and Nanog, and related biological characteristics of colon cancer stem cells, and to elucidate the clinical significance of this molecular regulatory network. Methods: Fifty-two cases of colorectal cancer tissue and adjacent tissue were collected at Nanyang City Central Hospital and Nanyang Second Hospital, Henan Province, from 2014 to 2016. Real-time quantitative polymerase chain reaction (qPCR) was used to detect the expression of lincRNA-ROR and miR-145 in colorectal cancer tissue and isolated colon cancer cells. The correlation between the expression of lincRNA-ROR, miR-145 and the clinicopathologic features of colon cancer was performed. CD44(-)CD133(-) and CD44(+) CD133(+) cells were isolated from SW1116 by using flow cytometry. The expression of CD44, CD133, Oct4, Sox2, Nanog, lincRNA-ROR and miR-145 in cells were detected by qPCR. The relationship between lincRNA-ROR, miR-145, Oct4, Sox2 and Nanog was analyzed by bioinformatics, dual luciferase reporter assay, qPCR and Western blot. The effects of silencing lincRNA-ROR on the proliferation and chemosensitivity of colon cancer stem cells were detected by MTT, colony formation. Results: LincRNA-ROR was frequently up-regulated and inversely correlated with miR-145 down-regulation in the colon cancer specimens( P cells were successfully isolated from SW1116 by flow cytometry. The levels of CD44, CD133, Oct4, Sox2, Nanog, lincRNA-ROR in CD44(+) CD133(+) cells were significantly increased, while miR-145 was decreased compared with CD44(-)CD133(-)cells( P cells were significantly reduced upon cell adherence, while miR-145 was significantly increased( P cancer stem cells proliferation and increased the sensitivity to chemotherapy. Conclusions: Linc-ROR functions as a key ceRNA to prevent core TFs, e. g., Oct4, Sox2, Nanog, from miR-145-mediated suppression in colon cancer stem cells

  6. Return of the mitochondrial DNA : Case study of mitochondrial genome evolution in the genus Fusarium

    NARCIS (Netherlands)

    Brankovics, Balázs

    2018-01-01

    Mitochondrial DNA played a prominent role in the fields of population genetics, systematics and evolutionary biology, due to its favorable characteristics, such as, uniparental inheritance, fast evolution and easy accessibility. However, the mitochondrial sequences have been mostly neglected in

  7. Strategic Map for Enceladus Plume Biosignature Sample Return

    Science.gov (United States)

    Sherwood, B.

    2014-12-01

    The discovery of jets emitting salty water from the interior of Saturn's small moon Enceladus is one of the most astounding results of the Cassini mission to date. The measured presence of organic species in the resulting plume, the finding that the jet activity is valved by tidal stretching at apocrone, the modeled lifetime of E-ring particles, and gravitational inference of a long-lived, deep, large water reservoir all indicate that the textbook conditions for habitability are met at Enceladus today: liquid water, biologically available elements, source of energy, and longevity of conducive conditions. Enceladus may be the best place in our solar system to search for direct evidence of biomarkers, and the plume provides a way to sample, analyze, and even return them to Earth for detailed analysis. For example, it is straightforward to define a Stardust-like, fly-through, plume ice-particle, dust, and gas collection mission. Concept engineering and evaluation indicate that the associated technical, programmatic, regulatory, and cost issues are quite unlike the Stardust precedent however, not least because of such a mission's Category-V, Restricted Earth Return, classification. The poster presents a strategic framework for systematic integration of the enabling issues: cultivation of science advocacy, resolution of diverse stakeholder concerns, development of verifiable and affordable technical solutions, validation of cost estimation methods, alignment with other candidate astrobiology missions, complementarity of international agency goals, and finally the identification of appropriate research and flight-mission opportunities. A strategic approach is essential if we are to know the astrobiological state of Enceladus in our lifetime, and two international teams are already dedicated to implementing key steps on this roadmap.

  8. Biological radioprotector

    International Nuclear Information System (INIS)

    Stefanescu, Ioan; Titescu, Gheorghe; Tamaian, Radu; Haulica, Ion; Bild, Walther

    2002-01-01

    According to the patent description, the biological radioprotector is deuterium depleted water, DDW, produced by vacuum distillation with an isotopic content lower than natural value. It appears as such or in a mixture with natural water and carbon dioxide. It can be used for preventing and reducing the ionizing radiation effects upon humans or animal organisms, exposed therapeutically, professionally or accidentally to radiation. The most significant advantage of using DDW as biological radioprotector results from its way of administration. Indeed no one of the radioprotectors currently used today can be orally administrated, what reduces the patients' compliance to prophylactic administrations. The biological radioprotector is an unnoxious product obtained from natural water, which can be administrated as food additive instead of drinking water. Dose modification factor is according to initial estimates around 1.9, what is a remarkable feature when one takes into account that the product is toxicity-free and side effect-free and can be administrated prophylactically as a food additive. A net radioprotective action of the deuterium depletion was evidenced experimentally in laboratory animals (rats) hydrated with DDW of 30 ppm D/(D+H) concentration as compared with normally hydrated control animals. Knowing the effects of irradiation and mechanisms of the acute radiation disease as well as the effects of administration of radiomimetic chemicals upon cellular lines of fast cell division, it appears that the effects of administrating DDW result from stimulation of the immunity system. In conclusion, the biological radioprotector DDW presents the following advantages: - it is obtained from natural products without toxicity; - it is easy to be administrated as a food additive, replacing the drinking water; - besides radioprotective effects, the product has also immunostimulative and antitumoral effects

  9. Marine biology

    International Nuclear Information System (INIS)

    Thurman, H.V.; Webber, H.H.

    1984-01-01

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index

  10. Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update

    Directory of Open Access Journals (Sweden)

    Nyl

    2016-02-01

    Full Text Available John Nyland,1,2 Alma Mattocks,1 Shane Kibbe,2 Alaa Kalloub,2,3 Joe W Greene,4 David N M Caborn2,3 1Athletic Training Program, Kosair Charities College of Health and Natural Sciences, Spalding University, Louisville, KY, USA; 2Department of Orthopedic Surgery, University of Louisville, Louisville, KY, USA; 3Shea Orthopedic Group, Louisville, KY, USA; 4Norton Orthopedic and Sports, Louisville, KY, USA Abstract: Anatomical discoveries and a growing appreciation of the knee as a complex organ are driving innovations in patient care decision-making following anterior cruciate ligament (ACL injury. Surgeons are increasing their efforts to restore combined mechanical-neurosensory ACL function and placing more consideration on when to reconstruct versus repair native anatomical structures. Surgical options now include primary repair with or without reinforcing the injured ACL with suture-based internal bracing, and growing evidence supports biological augmentation using platelet-rich plasma and mesenchymal stem cells to enhance tissue healing. Physical therapists and athletic trainers are increasing their efforts to facilitate greater athlete cognitive engagement during therapeutic exercise performance to better restore nonimpaired neuromuscular control activation amplitude and timing. Knee brace design and use needs to evolve to better match these innovations and their influence on the rehabilitation plan timetable. There is a growing appreciation for the multifaceted characteristics of the rehabilitation process and how they influence neuromuscular, educational, and psychobehavioral treatment goal achievement. Multiple sources may influence the athlete during the return to sports process and clinical outcome measures need to be refined to better evaluate these influences. This update summarizes contemporary ACL surgical, medical, and rehabilitation interventions and future trends. Keywords: arthroscopy, knee, function, outcomes, decision-making 

  11. Inactive nurses in Taiwan: human capital, intention to return to hospital nursing, and incentives for returning.

    Science.gov (United States)

    Yu, Hsing-Yi; Tang, Fu-In; Chen, I-Ju; Yin, Teresa J C; Chen, Chu-Chieh; Yu, Shu

    2016-04-01

    To investigate inactive nurses' human capital, intention to return to hospital nursing and incentives for returning. Few studies have discussed the loss of human capital with regard to inactive nurses and how to attract them to return to clinical work. Systematic random sampling was used, with 328 subjects completing the mailed questionnaires, resulting in a response rate of 25.4%. Inactive nurses not only had moderate to high human capital (average years of nursing experience was 10.29, with moderate to high levels of nursing professional commitment and nursing competence) and were young. Forty-three percent of subjects reported intending to return to hospital nursing. Sufficient nurse staffing, greater safety in the working environment, and re-entry preparation programmes were incentives for returning. Recruiting inactive nurses back to hospital work is vital and feasible as inactive nurses had a moderate to high degree of human capital. The most feasible way is offering reasonable working conditions, in particular, providing sufficient staffing, a safe working environment and re-entry preparation programmes. The findings confirm the human capital of inactive nurses and provide concrete directions for nursing managers to follow when recruiting inactive nurses to hospital nursing. © 2015 John Wiley & Sons Ltd.

  12. Mars Sample Return Landed with Red Dragon

    Science.gov (United States)

    Stoker, Carol R.; Lemke, Lawrence G.

    2013-01-01

    A Mars Sample Return (MSR) mission is the highest priority science mission for the next decade as recommended by the recent Decadal Survey of Planetary Science. However, an affordable program to carry this out has not been defined. This paper describes a study that examined use of emerging commercial capabilities to land the sample return elements, with the goal of reducing mission cost. A team at NASA Ames examined the feasibility of the following scenario for MSR: A Falcon Heavy launcher injects a SpaceX Dragon crew capsule and trunk onto a Trans Mars Injection trajectory. The capsule is modified to carry all the hardware needed to return samples collected on Mars including a Mars Ascent Vehicle (MAV), an Earth Return Vehicle (ERV) and Sample Collection and Storage hardware. The Dragon descends to land on the surface of Mars using SuperSonic Retro Propulsion (SSRP) as described by Braun and Manning [IEEEAC paper 0076, 2005]. Samples are acquired and deliverd to the MAV by a prelanded asset, possibly the proposed 2020 rover. After samples are obtained and stored in the ERV, the MAV launches the sample-containing ERV from the surface of Mars. We examined cases where the ERV is delivered to either low Mars orbit (LMO), C3 = 0 (Mars escape), or an intermediate energy state. The ERV then provides the rest of the energy (delta V) required to perform trans-Earth injection (TEI), cruise, and insertion into a Moon-trailing Earth Orbit (MTEO). A later mission, possibly a crewed Dragon launched by a Falcon Heavy (not part of the current study) retrieves the sample container, packages the sample, and performs a controlled Earth re-entry to prevent Mars materials from accidentally contaminating Earth. The key analysis methods used in the study employed a set of parametric mass estimating relationships (MERs) and standard aerospace analysis software codes modified for the MAV class of launch vehicle to determine the range of performance parameters that produced converged

  13. After the storm: the social relations of return to work following electrical injury.

    Science.gov (United States)

    Mansfield, Elizabeth; Stergiou-Kita, Mary; Kirsh, Bonnie; Colantonio, Angela

    2014-09-01

    In this study, we explored the experiences of 13 individuals who had suffered an electrical injury at work and had subsequently returned to work. In this article, we report on the social, institutional, and relational elements that workers perceived to influence return to work experiences and the provision of workplace accommodations. These elements included (a) worker resources, (b) job characteristics, (c) workplace setting, (d) injury elements, (e) workers' compensation context, and (f) supports and advocacy provided. We conclude that the availability and provision of supportive accommodations are influenced by a multiplicity of interrelated factors including the legitimacy of resulting impairments following electrical injury, institutional structures (e.g., compensation and health care systems), the social relations of work, and broader labor market and economic contexts. Those workers who were vulnerable because of factors such as employment circumstances or labor market conditions were often poorly supported when returning to work following electrical injury. © The Author(s) 2014.

  14. The probability of return conditional on migration duration: evidence from Kosovo

    Directory of Open Access Journals (Sweden)

    Kotorri Mrika

    2017-12-01

    Full Text Available The aim of this paper is to conceptualise the migration duration decision within the expected utility maximisation framework, and from that to derive and estimate an empirical proposition. For this purpose, the conceptual framework in Kotorri (2015 is extended where households decide to return to the home country conditional on their migration duration. In the empirical analysis, the Cox proportional hazards model is employed. This analysis is the first to investigate migration duration based on a random sample stemming from the Kosovo census of population conducted in 2011. The findings suggest rather mixed support for the household approach. The hazard to return decreases with income but not nonlinearly. The results indicate that household return migration behaviour is influenced by demographic characteristics, psychic income, and political factors.

  15. Nurses' views about returning to practice after a career break.

    Science.gov (United States)

    Durand, Mary Alison; Randhawa, Gurch

    Shortages in nursing staff have led to recruitment campaigns targeting nurses who have left the profession. The present study explored reasons why career-break nurses decide for or against a return to practice, as well as perceptions of nursing following return. Semistructured interview were conducted with 24 nurses who had returned recently to the profession and 28 nurses on a "career break". Findings revealed that those who returned did so when their personal circumstances allowed, and half returned as bank nurses in order to work flexible, family-friendly hours. Some non-returners reported that they could not afford to return because of childcare costs. Although still a caring one, the nurse's role is seen by returners as becoming increasingly technologically and administratively demanding. Flexibility with regard to working practices, increased salaries and demonstrating that it values its staff, were highlighted by interviewees generally as priority issues for the NHS if it wishes to recruit career-break nurses.

  16. When is return voluntary? Conditions of asylum in Lebanon

    Directory of Open Access Journals (Sweden)

    Amy Keith

    2018-02-01

    Full Text Available The decision of Syrian refugees in Lebanon to return to Syria must not be based on a deteriorating quality of asylum that creates physical, social and material pressures on decisions to return.

  17. Benefits of Returning to Work After ECT.

    Science.gov (United States)

    Berg, John Erik

    2013-03-01

    Severe unipolar or bipolar depression is often not helped by pharmacotherapy and/or psychotherapeutic treatment alone, whereas more than 80% of these patients remit after sessions of electroconvulsive treatment (ECT). Getting patients back to work after a severe depression may be important for maintaining the effect of ECT. Twenty consecutive patients remitted to an acute psychiatric hospital for depression underwent ECT. None of the patients had been working before the inpatient stay. Four patients were living on a permanent sickness allowance from the State (invalidity pension) before ECT, and thus were not expected to start work thereafter. Ten of the patients returned to work. Hospital treatment in Norway (including ECT) is provided free of charge with no copayments from the patient. The mean length of sick leave before ECT was 14.7 months. The 10 patients who returned to work had accrued public costs before their inpatient stays totalling NOK (Norwegian krone) 2,994,635 or a mean of NOK 299,463 per patient (&OV0556;1 = 9 NOK or $1 = 6 NOK ). The total public cost of their inpatient stays was NOK 1,680,000. During the first year after ECT, these 10 patients received NOK 2,680,000 in wages (NOK 3,238,300 during the mean number of months they were observed). Most of the patients (10 of 16) receiving ECT returned to work and within 2 years had earned more than the total cost both of their sick leave before admittance to hospital and the public cost of their 4 weeks' inpatient treatment. It is a pity that many countries, including Norway, only allow ECT as a treatment of last resort after failed psychotherapy or pharmacotherapy. Higher public spending is an inadvertent result of such a policy toward ECT.

  18. Literature, Advertising and Return of the Repressed

    Directory of Open Access Journals (Sweden)

    Francesco Ghelli

    2013-06-01

    Full Text Available Since I have faced with the hypothesis elaborated by Francesco Orlando, according to which literature is a form of return of the repressed, I wondered what – in our era of deregulation, end of censorship and taboos – could occupy the place of the repressed. One of the most influential sociologists, Zygmunt Bauman, has outlined the epochal passage from “the uneasiness in civilization” to today's “uneasiness of freedom”. The problem of desire today would not be a clash with a limit, but an indefinite freedom that is likely to turn into lost, loss of intensity and meaning.

  19. The Risk Management of Minimum Return Guarantees

    Directory of Open Access Journals (Sweden)

    Antje Mahayni

    2008-05-01

    Full Text Available Contracts paying a guaranteed minimum rate of return and a fraction of a positive excess rate, which is specified relative to a benchmark portfolio, are closely related to unit-linked life-insurance products and can be considered as alternatives to direct investment in the underlying benchmark. They contain an embedded power option, and the key issue is the tractable and realistic hedging of this option, in order to rigorously justify valuation by arbitrage arguments and prevent the guarantees from becoming uncontrollable liabilities to the issuer. We show how to determine the contract parameters conservatively and implement robust risk-management strategies.

  20. Corporate Spinoffs- A Risk and Return Perspective

    OpenAIRE

    Lundh, Hampus

    2007-01-01

    Spinoffs are an increasing phenomenon on the Swedish stock market. In this report one can read about factors that trigger spinoffs as well as about the short and medium term risk and return that spinoffs yield. I have observed 17 pre-spinoff companies that become 34 post-spinoff companies which continued to be traded on the stock market. For the purpose of the investigation I use time-series regression, and my model is the sin-gle-factor market model. I use this model to estimate the beta and...

  1. Structural Biology Fact Sheet

    Science.gov (United States)

    ... NIGMS NIGMS Home > Science Education > Structural Biology Structural Biology Tagline (Optional) Middle/Main Content Area PDF Version (688 KB) Other Fact Sheets What is structural biology? Structural biology is the study of how biological ...

  2. KINERJA KEUANGAN KONVENSIONAL, ECONOMIC VALUE ADDED, DAN RETURN SAHAM

    Directory of Open Access Journals (Sweden)

    Bambang Sudiyatno

    2011-09-01

    Full Text Available Penelitian ini bertujuan untuk menguji pengaruh kinerja keuangan konvensional; Return on Asset (ROA, Return on Equity (ROE, Residual Income (RI, dan kinerja keuangan yang lebih modern; Economic Value Added (EVA terhadap return saham pada perusahaan-perusahaan dalam industry makanan dan minuman yang terdaftar di Bursa Efek Indonesia. Pengambilan sampel dalam penelitian ini menggunakan metode sensus, karena semua perusahaan dalam industry makanan dan minuman digunakan sebagai sampel. Namun dalam proses samplingnya mengunakan metode purposive sampling, yaitu menggunakan sampel dengan criteria-kriteria tertentu. Hasil penelitian menunjukkan bahwa Return on Asset (ROA dan Residual Income (RI berpengaruh positif dan secara statistik signifikan terhadap return saham pada level signifikansi 1%. Sedangkan Return on Equity (ROE berpengaruh negative dan secara statistik signifikan terhadap return saham pada level signifikansi 10%, dan Economic Value Added (ERA berpengaruh positif tetapi tidak signifikan terhadap return saham.This study aims to test the effect of conventional financial performance i.e. Return on Asset (ROA, Return on Equity (ROE, Residual Income (RI, and the more modern financial performance which is Economic Value Added (EVA toward stock returns on companies in the food and beverage industry listed in Indonesia Stock Exchange. Sampling technique in this study uses the census method, all companies in the food and beverage industry are used as a sample. The process of sampling using purposive sampling method. The result shows that Return On Asset (ROA and Residual Income (RI are positive and statistic significant impact on the stock returns at significance level 1%. While the Return on Equity (ROE is negative and statistic significant impact on the stock returns at significance level 10%, Economic Value Added (EVA is positive and statistic not significant impact on the stock returns.

  3. Global Variance Risk Premium and Forex Return Predictability

    OpenAIRE

    Aloosh, Arash

    2014-01-01

    In a long-run risk model with stochastic volatility and frictionless markets, I express expected forex returns as a function of consumption growth variances and stock variance risk premiums (VRPs)—the difference between the risk-neutral and statistical expectations of market return variation. This provides a motivation for using the forward-looking information available in stock market volatility indices to predict forex returns. Empirically, I find that stock VRPs predict forex returns at a ...

  4. Sample Return Mission to the South Pole Aitken Basin

    Science.gov (United States)

    Duke, M. B.; Clark, B. C.; Gamber, T.; Lucey, P. G.; Ryder, G.; Taylor, G. J.

    1999-01-01

    The South Pole Aitken Basin (SPA) is the largest and oldest observed feature on the Moon. Compositional and topographic data from Galileo, Clementine, and Lunar Prospector have demonstrated that SPA represents a distinctive major lunar terrane, which has not been sampled either by sample return missions (Apollo, Luna) or by lunar meteorites. The floor of SPA is characterized by mafic compositions enriched in Fe, Ti, and Th in comparison to its surroundings. This composition may represent melt rocks from the SPA event, which would be mixtures of the preexisting crust and mantle rocks. However, the Fe content is higher than expected, and the large Apollo basin, within SPA, exposes deeper material with lower iron content. Some of the Fe enrichment may represent mare and cryptomare deposits. No model adequately accounts for all of the characteristics of the SPA and disagreements are fundamental. Is mantle material exposed or contained as fragments in melt rock and breccias? If impact melt is present, did the vast sheet differentiate? Was the initial mantle and crust compositionally different from other regions of the Moon? Was the impact event somehow peculiar, (e.g., a low-velocity impact)? The precise time of formation of the SPA is unknown, being limited only by the initial differentiation of the Moon and the age of the Imbrium event, believed to be 3.9 b.y. The questions raised by the SPA can be addressed only with detailed sample analysis. Analysis of the melt rocks, fragments in breccias, and basalts of SPA can address several highly significant problems for the Moon and the history of the solar system. The time of formation of SPA, based on analysis of melt rocks formed in the event. would put limits on the period of intense bombardment of the Moon, which has been inferred by some to include a "terminal cataclysm." If close to 3.9 Ga, the presumed age of the Imbrium Basin, the SPA date would confirm the lunar cataclysm. This episode, if it occurred, would have

  5. Research on scholarships holders who studied abroad and returned to Serbia

    Directory of Open Access Journals (Sweden)

    Nena A. Vasojevic

    2017-10-01

    Full Text Available Knowledge has become the most valuable resource of the new era and the resource of the future. The intention of this study is to improve knowledge about the problem of migration of educated people from Serbia from the perspective of scholarship holders who, after being abroad, returned to their country. The aim of this research is to show the profile of the scholarship holders of post-academic and post-graduate students, who studied abroad and then returned to Serbia. Their motives for departure and return, as well as their perception of integration into the work environment in Serbia and utilization of their knowledge is presented. Methods: For the purpose of this research a questionnaire was constructed which was distributed online. Collected data were analysed using statistical tools. Results: This research has shown that the primary motive for education abroad is the desire for personal development. It has also been shown that an important factor for the return of students from abroad is their expectation of comparative advantage in the labour market and their belief of getting a desired job. Apart from this, it is shown that the scholarship holders only partially used the acquired knowledge and thus, do not have enough influence in the development of their organizations.Conclusion: The main research contribution is reflected in the improvement of the knowledge about the motivation of scholars to return from developed countries and highlighted problems which scholarship holders have after returning.Implications and research limitation: the results obtained can be generalised to countries that are passing or have recently moved a transition, and are similar in cultural characteristics. The present contains certain limitations that must be taken into account while interpreting final results. The most significant constraint is the sample size, but the obtained results, especially the motives of the scientific experts for a return to the country

  6. Returning to work one year after childbirth: data from the mother-child cohort EDEN.

    Science.gov (United States)

    Wallace, Maeve; Saurel-Cubizolles, Marie-Josèphe

    2013-10-01

    The amount of time women spend out of work postpartum has implications for both health and economic trajectories which may result in long-term social inequities or exacerbate those already existing. The purpose of this investigation was to describe the characteristics of women who return to work within the first year postpartum and to identify specific occupational and health factors associated with returning to work among women who worked during pregnancy. The EDEN cohort is comprised of pregnant women recruited in two French university hospitals before 24 weeks gestation with a singleton pregnancy. Questionnaires were administered at 4, 8, and 12 months after birth. Multivariate logistic regression was used to model the odds of returning to work within 1 year of childbirth with inclusion of sociodemographic, health, and occupational variables that were significantly related to returning to work at the level of p worked during pregnancy in our sample had resumed work before their infant's first birthday. After adjustment, occupational level, full-time work, standing position, job reward, desire to change job, education, and father's occupational level remained significantly associated with returning to work. Women's perception of their work as rewarding was the strongest predictor of resuming employment (OR comparing high reward to low reward: 2.48, 95 % CI: 1.60-3.83 for women with parity 0 or 1). Experiencing an adverse birth outcome had no relation to returning to work within 1 year postpartum. Across all indicator variables, women of higher socioeconomic status or with greater resources had greater odds of returning to work compared to those of lower status. This suggests that the crucial period of employment transition around the time of childbirth may intensify preexisting social inequalities.

  7. Investigating the excess return of contrarian strategy in the active ...

    African Journals Online (AJOL)

    Obtaining the appropriate rate of return is the most important expectation of investors in the investment process and different statategies have been used by investors to gain a required rate of return. Contrarian strategy is one the strategies used recently to predict the return of stock using the historical information. Contrarian ...

  8. Consumption Risk and the Cross Section of Expected Returns.

    Science.gov (United States)

    Parker, Jonathan A.; Julliard, Christian

    2005-01-01

    This paper evaluates the central insight of the consumption capital asset pricing model that an asset's expected return is determined by its equilibrium risk to consumption. Rather than measure risk by the contemporaneous covariance of an asset's return and consumption growth, we measure risk by the covariance of an asset's return and consumption…

  9. 27 CFR 25.211 - Beer returned to brewery.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer returned to brewery..., DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Returned to Brewery § 25.211 Beer returned to brewery. (a) General. Beer, produced in the United States, on which the brewer has paid or determined the tax may be...

  10. 22 CFR 42.22 - Returning resident aliens.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Returning resident aliens. 42.22 Section 42.22... Returning resident aliens. (a) Requirements for returning resident status. An alien shall be classifiable as... presented that: (1) The alien had the status of an alien lawfully admitted for permanent residence at the...

  11. 26 CFR 301.6063-1 - Signing of partnership returns.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Signing of partnership returns. 301.6063-1 Section 301.6063-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....6063-1 Signing of partnership returns. For provisions relating to the signing of returns of partnership...

  12. DETERMINANTS OF RETURN ON EQUITY OF COOPERATIVE BANKS IN POLAND

    Directory of Open Access Journals (Sweden)

    Anna Bieniasz

    2016-03-01

    Full Text Available The aim of the study was to analyse the diversity of return on equity in the cooperative banks in Poland in 2010– 2014. The analysis was conducted using data of the Polish Financial Supervision Authority, on the basis of a modifi ed decomposition rate of return on equity. Assessment of the rate of return on equity was made in a size of banks, as determined by the value of assets. In addition, in order to determine the strength and direction of impact the individual components of the model on the formation of return on equity method was applied functional. The study suggests that cooperative banks eff ectively use the equity, because the rate of return on equity was signifi cantly higher than the rate of return on assets. The average return on assets in 2010–2014 was relatively lower in the largest banks and ranged from 0.7–0.9%, and the smallest banks return on assets was approximately 1%. In turn, the return on equity was higher at banks with major assets (over 200 million PLN. In 2013–2014 the rate of return both on assets and equity expressly declined. The main determinants of changes in return on equity were changing the multiplier reduction of profi t from banking activities by operating costs and costs of banking risk and return on assets, as well as measured result on banking activities.

  13. 31 CFR 10.28 - Return of client's records.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Return of client's records. 10.28... § 10.28 Return of client's records. (a) In general, a practitioner must, at the request of a client, promptly return any and all records of the client that are necessary for the client to comply with his or...

  14. 14 CFR 49.21 - Return of original conveyance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Return of original conveyance. 49.21... RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.21 Return of original conveyance. If a person submitting a conveyance for recording wants the original returned to him, he must submit a true...

  15. Biology Notes.

    Science.gov (United States)

    School Science Review, 1982

    1982-01-01

    Describes laboratory procedures, demonstrations, and classroom materials, including "diet poker" (nutrition game); an experiment on enzyme characteristics; demonstrations of yeast anaerobic respiration and color preference in Calliphora larvae; method to extract eugenol from clove oil to show antibiotic properties; and Benedict's test.…

  16. Value at Risk and Hedge Fund Return - Does High Risk Bring High Return?

    OpenAIRE

    Jing, Tao; Zhao, Hongxiang

    2010-01-01

    This paper mainly focuses on the correlation between live hedge fund return and their value at risk (VaR), and is based on the historical data from May 2000 to April 2010. The authors adopt portfolio level analyses and fund level cross-sectional regression, and find that there is significant positive correlation, both statistically and economically, between the hedge fund return and VaRs (parametric, non-parametric and GARCH). Further research is conducted by sub-dividing the overall period i...

  17. Range-based volatility, expected stock returns, and the low volatility anomaly

    Science.gov (United States)

    2017-01-01

    One of the foundations of financial economics is the idea that rational investors will discount stocks with more risk (volatility), which will result in a positive relation between risk and future returns. However, the empirical evidence is mixed when determining how volatility is related to future returns. In this paper, we examine this relation using a range-based measure of volatility, which is shown to be theoretically, numerically, and empirically superior to other measures of volatility. In a variety of tests, we find that range-based volatility is negatively associated with expected stock returns. These results are robust to time-series multifactor models as well as cross-sectional tests. Our findings contribute to the debate about the direction of the relationship between risk and return and confirm the presence of the low volatility anomaly, or the anomalous finding that low volatility stocks outperform high volatility stocks. In other tests, we find that the lower returns associated with range-based volatility are driven by stocks with lottery-like characteristics. PMID:29190652

  18. Range-based volatility, expected stock returns, and the low volatility anomaly.

    Science.gov (United States)

    Blau, Benjamin M; Whitby, Ryan J

    2017-01-01

    One of the foundations of financial economics is the idea that rational investors will discount stocks with more risk (volatility), which will result in a positive relation between risk and future returns. However, the empirical evidence is mixed when determining how volatility is related to future returns. In this paper, we examine this relation using a range-based measure of volatility, which is shown to be theoretically, numerically, and empirically superior to other measures of volatility. In a variety of tests, we find that range-based volatility is negatively associated with expected stock returns. These results are robust to time-series multifactor models as well as cross-sectional tests. Our findings contribute to the debate about the direction of the relationship between risk and return and confirm the presence of the low volatility anomaly, or the anomalous finding that low volatility stocks outperform high volatility stocks. In other tests, we find that the lower returns associated with range-based volatility are driven by stocks with lottery-like characteristics.

  19. Range-based volatility, expected stock returns, and the low volatility anomaly.

    Directory of Open Access Journals (Sweden)

    Benjamin M Blau

    Full Text Available One of the foundations of financial economics is the idea that rational investors will discount stocks with more risk (volatility, which will result in a positive relation between risk and future returns. However, the empirical evidence is mixed when determining how volatility is related to future returns. In this paper, we examine this relation using a range-based measure of volatility, which is shown to be theoretically, numerically, and empirically superior to other measures of volatility. In a variety of tests, we find that range-based volatility is negatively associated with expected stock returns. These results are robust to time-series multifactor models as well as cross-sectional tests. Our findings contribute to the debate about the direction of the relationship between risk and return and confirm the presence of the low volatility anomaly, or the anomalous finding that low volatility stocks outperform high volatility stocks. In other tests, we find that the lower returns associated with range-based volatility are driven by stocks with lottery-like characteristics.

  20. Health Status and Experience of the Migrant Workers Returned from Spain to Colombia: A Qualitative Approach.

    Science.gov (United States)

    Zapata-Villa, Carolina; Agudelo-Suárez, Andrés A; Cardona-Arango, Doris; Ronda-Pérez, Elena

    2017-12-14

    This study aims to understand the migratory experience and the employment, work and health conditions of the returned migrants from Spain to Colombia. A qualitative study was conducted by means of 23 semi-structured interviews with Colombian returned migrant workers. Qualitative narrative content analysis was performed using Atlas.Ti software. Main findings are represented by nine categories emerged from the participants' discourses: (1) impact of the economic crisis on work and employment conditions in Spain, (2) economic crisis and return, (3) characteristics of returnees, (4) perception of the returnees about Colombia, (5) the role of social support networks, (6) employment and working conditions in Colombia, (7) health and wellbeing, (8) future plans and expectations, (9) the experience of being immigrant. Adjustment difficulties in participants are evidenced by the return migration process and the conditions of the social, political and economic system in Colombia. Return migration represents the reconfiguration of personal and working lives of this population. This situation requires the development of global policies and strategies in public health to facilitate the adaptation of these people.