WorldWideScience

Sample records for bioguid resolving discovering

  1. Time-resolved 2-million-year-old supernova activity discovered in Earth's microfossil record.

    Science.gov (United States)

    Ludwig, Peter; Bishop, Shawn; Egli, Ramon; Chernenko, Valentyna; Deneva, Boyana; Faestermann, Thomas; Famulok, Nicolai; Fimiani, Leticia; Gómez-Guzmán, José Manuel; Hain, Karin; Korschinek, Gunther; Hanzlik, Marianne; Merchel, Silke; Rugel, Georg

    2016-08-16

    Massive stars ([Formula: see text]), which terminate their evolution as core-collapse supernovae, are theoretically predicted to eject [Formula: see text] of the radioisotope (60)Fe (half-life 2.61 Ma). If such an event occurs sufficiently close to our solar system, traces of the supernova debris could be deposited on Earth. Herein, we report a time-resolved (60)Fe signal residing, at least partially, in a biogenic reservoir. Using accelerator mass spectrometry, this signal was found through the direct detection of live (60)Fe atoms contained within secondary iron oxides, among which are magnetofossils, the fossilized chains of magnetite crystals produced by magnetotactic bacteria. The magnetofossils were chemically extracted from two Pacific Ocean sediment drill cores. Our results show that the (60)Fe signal onset occurs around 2.6 Ma to 2.8 Ma, near the lower Pleistocene boundary, terminates around 1.7 Ma, and peaks at about 2.2 Ma.

  2. Time-resolved 2-million-year-old supernova activity discovered in Earth's microfossil record

    Science.gov (United States)

    Ludwig, Peter; Bishop, Shawn; Egli, Ramon; Chernenko, Valentyna; Deneva, Boyana; Faestermann, Thomas; Famulok, Nicolai; Fimiani, Leticia; Gómez-Guzmán, José Manuel; Hain, Karin; Korschinek, Gunther; Hanzlik, Marianne; Merchel, Silke; Rugel, Georg

    2016-08-01

    Massive stars (M≳10 M⊙M≳10 M⊙), which terminate their evolution as core-collapse supernovae, are theoretically predicted to eject >10-5M⊙>10-5M⊙ of the radioisotope 60Fe (half-life 2.61 Ma). If such an event occurs sufficiently close to our solar system, traces of the supernova debris could be deposited on Earth. Herein, we report a time-resolved 60Fe signal residing, at least partially, in a biogenic reservoir. Using accelerator mass spectrometry, this signal was found through the direct detection of live 60Fe atoms contained within secondary iron oxides, among which are magnetofossils, the fossilized chains of magnetite crystals produced by magnetotactic bacteria. The magnetofossils were chemically extracted from two Pacific Ocean sediment drill cores. Our results show that the 60Fe signal onset occurs around 2.6 Ma to 2.8 Ma, near the lower Pleistocene boundary, terminates around 1.7 Ma, and peaks at about 2.2 Ma.

  3. Theoretical Considerations of Bio-guided Music Therapy

    Directory of Open Access Journals (Sweden)

    Eric B Miller

    2011-11-01

    Full Text Available Music therapists rarely have the opportunity to consider a new model of music therapy and need to review prior models and theoretical approaches to make an informed determination regarding Bio-guided Music Therapy. While initially appearing to fall within the confines of Behavioral Music Therapy, technical advances in sound reproduction, physiological data acquisition methods, as well as innovative application techniques are argued to bring the bio-guided approach into the realm of in-the-moment improvisation. Bio-guided Music Therapy distinguishes itself from other music therapy models by virtue of the client's physiological data being presented in real-time either musically or visually back to the client or the therapist during the therapy session. This real-time data may be presented in key, scale and tempo for flexibility in musical interaction with the music therapist or group. General treatment areas include ADHD, Stress/anxiety, dementia, depression and addictions. The resulting charts and graphs document the impact of the music therapy session in the language of mainstream medicine, readily accessible to other medical professionals.

  4. Bio-guided Isolation of a New Sesterterpene from Serjania goniocarpa.

    Science.gov (United States)

    Quintal-Novelo, Carlos; Torres-Tapia, Luis W; Moo-Puc, Rosa; Peraza-Sanchez, Sergio R

    2015-09-01

    Serjania goniocarpa is a plant used in Mayan traditional medicine as a remedy for the treatment of cancer-like symptoms. Bio-guided fractionation of the methanol extract of the leaves led to the isolation of an α- and β-amyrin mixture, palmitic acid, phytol and the new sesterterpene goniocarpic acid whose structure was elucidated by IR, GC-MS, and NMR spectroscopic analyses. Goniocarpic acid exhibited cytotoxic and antiproliferative activity against several cancer cell lines.

  5. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L.

    Science.gov (United States)

    Geng, Fang; Yang, Li; Chou, Guixin; Wang, Zhengtao

    2010-07-01

    Ethanolic extract of the seeds of Plantago asiatica L. showed significant inhibitory activity of angiotensin-converting enzyme (ACE) determined by monitoring the transformation from a substrate hippuryl-histidyl-leucine (HHL) to the product hippuric acid (HA) in vitro using an UPLC-MS method. The bioguided fractionation of the extract resulted in the isolation of four ACE inhibitory active phenylpropanoid glycosides acteoside, isoacteoside, plantainoside D, and plantamajoside with IC(50) values of 2.69 mM, 2.46 mM, 2.17 mM, and 2.47 mM, respectively. Their structures were elucidated through the analysis of NMR, UV, IR and MS data. Our study is the first demonstration that Plantago asiatica L. and its major constituents have ACE inhibitory activity in vitro. It is assumed that the identified compounds contribute to the angiotensin-converting enzyme-inhibitory activity of the extract.

  6. Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste.

    Science.gov (United States)

    Parejo, Irene; Viladomat, Francesc; Bastida, Jaume; Schmeda-Hirschmann, Guillermo; Burillo, Jesús; Codina, Carles

    2004-04-07

    A bioguided isolation of an aqueous extract of fennel waste led to the isolation of 12 major phenolic compounds. Liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry (LC/UV/APCI-MS) combined with spectroscopic methods (NMR) was used for compound identification. Radical scavenging activity was tested using three methods: DPPH*, superoxide nitro-blue tetrazolium hypoxanthine/xanthine oxidase, and *OH/luminol chemiluminescence. In addition to products described in the literature, eight antioxidant compounds were isolated and identified for the first time in fennel: 3-caffeoylquinic acid, 4-caffeoylquinic acid, 1,5-O-dicaffeoylquinic acid, rosmarinic acid, eriodictyol-7-O-rutinoside, quercetin-3-O-galactoside, kaempferol-3-O-rutinoside, and kaempferol-3-O-glucoside. The structures of eriodictyol-7-O-rutinoside and quercetin-3-O-glucuronide were completely elucidated by two-dimensional NMR experiments. The isolated compounds exhibited a strong antiradical scavenging activity, which may contribute to the interpretation of the pharmacological effects of fennel.

  7. Discovering Wavelets

    CERN Document Server

    Aboufadel, Edward

    1999-01-01

    An accessible and practical introduction to wavelets. With applications in image processing, audio restoration, seismology, and elsewhere, wavelets have been the subject of growing excitement and interest over the past several years. Unfortunately, most books on wavelets are accessible primarily to research mathematicians. Discovering Wavelets presents basic and advanced concepts of wavelets in a way that is accessible to anyone with only a fundamental knowledge of linear algebra. The basic concepts of wavelet theory are introduced in the context of an explanation of how the FBI uses wavelets

  8. Phytochemical study bioguided by the myorelaxant activity of the crude extract from stem bark of Hymenaea courbaril L (JatobÃ).

    OpenAIRE

    Gabrieli da Penha Bezerra

    2013-01-01

    Hymenaea courbaril L. (Fabaceae), popularly known as "Jatoba", is used in folk medicine to treat respiratory diseases such as bronchitis and asthma. This study evaluated the effect of H. courbaril on the contractile of rat isolated trachea, as well as its potential antioxidant and anti-inflammatory, through an interdisciplinary study bioguided by myorelaxant activity of the ethanol extract from stem bark (EEHC). Chromatoghrafic fractionation of EEHC resulted in fractions of increasing polarit...

  9. Discovering Network Structure Beyond Communities

    OpenAIRE

    Nishikawa, Takashi; Adilson E Motter

    2011-01-01

    To understand the formation, evolution, and function of complex systems, it is crucial to understand the internal organization of their interaction networks. Partly due to the impossibility of visualizing large complex networks, resolving network structure remains a challenging problem. Here we overcome this difficulty by combining the visual pattern recognition ability of humans with the high processing speed of computers to develop an exploratory method for discovering groups of nodes chara...

  10. Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum

    Directory of Open Access Journals (Sweden)

    Widrlechner Mark P

    2009-07-01

    Full Text Available Abstract Background Light-dependent activities against enveloped viruses in St. John's Wort (Hypericum perforatum extracts have been extensively studied. In contrast, light-independent antiviral activity from this species has not been investigated. Results Here, we identify the light-independent inhibition of human immunodeficiency virus-1 (HIV-1 by highly purified fractions of chloroform extracts of H. perforatum. Both cytotoxicity and antiviral activity were evident in initial chloroform extracts, but bioassay-guided fractionation produced fractions that inhibited HIV-1 with little to no cytotoxicity. Separation of these two biological activities has not been reported for constituents responsible for the light-dependent antiviral activities. Antiviral activity was associated with more polar subfractions. GC/MS analysis of the two most active subfractions identified 3-hydroxy lauric acid as predominant in one fraction and 3-hydroxy myristic acid as predominant in the other. Synthetic 3-hydroxy lauric acid inhibited HIV infectivity without cytotoxicity, suggesting that this modified fatty acid is likely responsible for observed antiviral activity present in that fraction. As production of 3-hydroxy fatty acids by plants remains controversial, H. perforatum seedlings were grown sterilely and evaluated for presence of 3-hydroxy fatty acids by GC/MS. Small quantities of some 3-hydroxy fatty acids were detected in sterile plants, whereas different 3-hydroxy fatty acids were detected in our chloroform extracts or field-grown material. Conclusion Through bioguided fractionation, we have identified that 3-hydroxy lauric acid found in field grown Hypericum perforatum has anti-HIV activity. This novel anti-HIV activity can be potentially developed into inexpensive therapies, expanding the current arsenal of anti-retroviral agents.

  11. Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook. Tronc. in silver catfish Rhamdia quelen

    Directory of Open Access Journals (Sweden)

    SIMONE C. BENOVIT

    2015-09-01

    Full Text Available This work aimed to determine the efficacy of the essential oil of A. gratissima as anesthetic for silver catfish, and to perform the bio-guided fractionation of essential oil aiming to isolate compounds responsible for the noted effects. Fish were submitted to anesthesia bath with essential oil, its fractions and isolated compounds to determine time of anesthetic induction and recovery. Eugenol (50 mg L-1 was used as positive control. Essential oil of A. gratissima was effective as an anesthetic at concentrations of 300 to 900 mg L-1. Fish presented involuntary muscle contractions during induction and recovery. The bio-guided fractionation of essential oil furnishedE-(--pinocamphone, (--caryophyllene oxide, (--guaiol and (+-spathulenol. E-(--pinocamphone caused the same side effects observed for essential oil. (--Caryophyllene oxide, (--guaiol and (+-spathulenol showed only sedative effects at proportional concentrations to those of the constituents in essential oil. (+-Spathulenol (51.2 mg L-1 promoted deep anesthesia without side effects. A higher concentration of (+-spathulenol, and lower or absent amounts ofE-(--pinocamphone could contribute to increase the activity and safety of the essential oil of A. gratissima. (+-Spathulenol showed potent sedative and anesthetic activities in silver catfish, and could be considered as a viable compound for the development of a new anesthetic.

  12. Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen.

    Science.gov (United States)

    Benovit, Simone C; Silva, Lenise L; Salbego, Joseânia; Loro, Vania L; Mallmann, Carlos A; Baldisserotto, Bernardo; Flores, Erico M M; Heinzmann, Berta M

    2015-09-01

    This work aimed to determine the efficacy of the essential oil of A. gratissima as anesthetic for silver catfish, and to perform the bio-guided fractionation of essential oil aiming to isolate compounds responsible for the noted effects. Fish were submitted to anesthesia bath with essential oil, its fractions and isolated compounds to determine time of anesthetic induction and recovery. Eugenol (50 mg L(-1)) was used as positive control. Essential oil of A. gratissima was effective as an anesthetic at concentrations of 300 to 900 mg L(-1). Fish presented involuntary muscle contractions during induction and recovery. The bio-guided fractionation of essential oil furnished E-(-)-pinocamphone, (-)-caryophyllene oxide, (-)-guaiol and (+)-spathulenol. E-(-)-pinocamphone caused the same side effects observed for essential oil. (-)-Caryophyllene oxide, (-)-guaiol and (+)-spathulenol showed only sedative effects at proportional concentrations to those of the constituents in essential oil. (+)-Spathulenol (51.2 mg L(-1)) promoted deep anesthesia without side effects. A higher concentration of (+)-spathulenol, and lower or absent amounts ofE-(-)-pinocamphone could contribute to increase the activity and safety of the essential oil of A. gratissima. (+)-Spathulenol showed potent sedative and anesthetic activities in silver catfish, and could be considered as a viable compound for the development of a new anesthetic.

  13. A STATISTICAL INTELLIGENCE (STI) APPROACH TO DISCOVERING SPURIOUS CORRELATION IN A PHYSICAL MODEL AND RESOLVING THE PROBLEM WITH AN EXAMPLE OF DESIGNING A PULSE JET MIXING SYSTEM AT HANFORD

    Energy Technology Data Exchange (ETDEWEB)

    Amidan, Brett G.; Piepel, Gregory F.; Heredia-Langner, Alejandro; Meyer, Perry A.; Wells, Beric E.; Fort, James A.; Bamberger, Judith A.; Kuhn, William L.

    2010-07-23

    Pulse jet mixing tests were conducted to support the design of mixing systems for the Hanford Waste Treatment and Immobilization Plant. A physical approach (based on hydro-dynamic behavior) and two semi-empirical (SE) approaches were applied to the data to develop models for predicting two response variables (critical-suspension velocity and cloud height). Tests were conducted at three geometric scales using multiple noncohesive simulants and levels of possibly influential factors. The physical modeling approach based on hydro- dynamic behavior was first attempted, but this approach can yield models with spurious correlation. To overcome this dilemma, two semi-empirical (SE) models were developed by generalizing the form of the physical model using dimensional and/or nondimensional (ND) variables. The results of applying statistical intelligence (STI) tools to resolve the spurious correlation problem via fitting the physical and SE models are presented and compared. Considering goodness-of-fit, prediction performance, spurious correlation, and the need to extrapolate, the SE models based on ND variables are recommended.

  14. Discovering network structure beyond communities.

    Science.gov (United States)

    Nishikawa, Takashi; Motter, Adilson E

    2011-01-01

    To understand the formation, evolution, and function of complex systems, it is crucial to understand the internal organization of their interaction networks. Partly due to the impossibility of visualizing large complex networks, resolving network structure remains a challenging problem. Here we overcome this difficulty by combining the visual pattern recognition ability of humans with the high processing speed of computers to develop an exploratory method for discovering groups of nodes characterized by common network properties, including but not limited to communities of densely connected nodes. Without any prior information about the nature of the groups, the method simultaneously identifies the number of groups, the group assignment, and the properties that define these groups. The results of applying our method to real networks suggest the possibility that most group structures lurk undiscovered in the fast-growing inventory of social, biological, and technological networks of scientific interest.

  15. Discovering Network Structure Beyond Communities

    CERN Document Server

    Nishikawa, Takashi; 10.1038/srep00151

    2011-01-01

    To understand the formation, evolution, and function of complex systems, it is crucial to understand the internal organization of their interaction networks. Partly due to the impossibility of visualizing large complex networks, resolving network structure remains a challenging problem. Here we overcome this difficulty by combining the visual pattern recognition ability of humans with the high processing speed of computers to develop an exploratory method for discovering groups of nodes characterized by common network properties, including but not limited to communities of densely connected nodes. Without any prior information about the nature of the groups, the method simultaneously identifies the number of groups, the group assignment, and the properties that define these groups. The results of applying our method to real networks suggest the possibility that most group structures lurk undiscovered in the fast-growing inventory of social, biological, and technological networks of scientific interest.

  16. Discover your dream

    Institute of Scientific and Technical Information of China (English)

    杨红

    2010-01-01

    《盗梦空间》(Inception)票房大热,几乎在全球掀起了一股探梦狂潮,现在就让我们跟随Inception主角Cobb的叙述,来discover your dream(探索你的梦境)吧。

  17. Discovering the Solar System

    Science.gov (United States)

    Jones, Barrie W.

    1999-04-01

    Discovering the Solar System Barrie W. Jones The Open University, Milton Keynes, UK Discovering the Solar System is a comprehensive, up-to-date account of the Solar System and of the ways in which the various bodies have been investigated and modelled. The approach is thematic, with sequences of chapters on the interiors of planetary bodies, on their surfaces, and on their atmospheres. Within each sequence there is a chapter on general principles and processes followed by one or two chapters on specific bodies. There is also an introductory chapter, a chapter on the origin of the Solar System, and a chapter on asteroids, comets and meteorites. Liberally illustrated with diagrams, black and white photographs and colour plates, Discovering the Solar System also features: * tables of essential data * question and answers within the text * end of section review questions with answers and comments Discovering the Solar System is essential reading for all undergraduate students for whom astronomy or planetary science are components of their degrees, and for those at a more advanced level approaching the subject for the first time. It will also be of great interest to non-specialists with a keen interest in astronomy. A small amount of scientific knowledge is assumed plus familiarity with basic algebra and graphs. There is no calculus. Praise for this book includes: ".certainly qualifies as an authoritative text. The author clearly has an encyclopedic knowledge of the subject." Meteorics and Planetary Science ".liberally doused with relevant graphs, tables, and black and white figures of good quality." EOS, Transactions of the American Geophysical Union ".one of the best books on the Solar System I have seen. The general accuracy and quality of the content is excellent." Journal of the British Astronomical Association

  18. Discovering Phonemes of Bidayuh

    OpenAIRE

    Jecky Misieng

    2012-01-01

    There are generally three views of the notion of a phoneme. The structuralist view of the phoneme focuses on this language phenomenon as a phonetic reality. In discovering phonemes of a language, phonologists who hold this view will look for minimal contrasting pairs as a way to determine contrasting sounds of that language. They will also look for allophones or two sounds of the same phoneme which may appear in complementary distribution. This paper will discuss the possible application of t...

  19. Students Discover Unique Planet

    Science.gov (United States)

    2008-12-01

    Three undergraduate students, from Leiden University in the Netherlands, have discovered an extrasolar planet. The extraordinary find, which turned up during their research project, is about five times as massive as Jupiter. This is also the first planet discovered orbiting a fast-rotating hot star. Omega Centauri ESO PR Photo 45a/08 A planet around a hot star The students were testing a method of investigating the light fluctuations of thousands of stars in the OGLE database in an automated way. The brightness of one of the stars was found to decrease for two hours every 2.5 days by about one percent. Follow-up observations, taken with ESO's Very Large Telescope in Chile, confirmed that this phenomenon is caused by a planet passing in front of the star, blocking part of the starlight at regular intervals. According to Ignas Snellen, supervisor of the research project, the discovery was a complete surprise. "The project was actually meant to teach the students how to develop search algorithms. But they did so well that there was time to test their algorithm on a so far unexplored database. At some point they came into my office and showed me this light curve. I was completely taken aback!" The students, Meta de Hoon, Remco van der Burg, and Francis Vuijsje, are very enthusiastic. "It is exciting not just to find a planet, but to find one as unusual as this one; it turns out to be the first planet discovered around a fast rotating star, and it's also the hottest star found with a planet," says Meta. "The computer needed more than a thousand hours to do all the calculations," continues Remco. The planet is given the prosaic name OGLE2-TR-L9b. "But amongst ourselves we call it ReMeFra-1, after Remco, Meta, and myself," says Francis. The planet was discovered by looking at the brightness variations of about 15 700 stars, which had been observed by the OGLE survey once or twice per night for about four years between 1997 and 2000. Because the data had been made public

  20. Discovering system requirements

    Energy Technology Data Exchange (ETDEWEB)

    Bahill, A.T.; Bentz, B. [Univ. of Arizona, Tucson, AZ (United States). Systems and Industrial Engineering; Dean, F.F. [Sandia National Labs., Albuquerque, NM (United States)

    1996-07-01

    Cost and schedule overruns are often caused by poor requirements that are produced by people who do not understand the requirements process. This report provides a high-level overview of the system requirements process, explaining types, sources, and characteristics of good requirements. System requirements, however, are seldom stated by the customer. Therefore, this report shows ways to help you work with your customer to discover the system requirements. It also explains terminology commonly used in the requirements development field, such as verification, validation, technical performance measures, and the various design reviews.

  1. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Elisa Colombo

    2015-01-01

    Full Text Available Calendula officinalis L. has been largely known for its topical anti-inflammatory properties; however, there are no experimental evidences about its antiphlogistic effect at the gastric level. To investigate whether marigold might exert an activity against gastric inflammation, a CH2Cl2 extract obtained from C. officinalis flowers was evaluated in vitro on the NF-κB pathway. The lipophilic extract demonstrated a significant inhibitory effect on the NF-κB driven transcription. The identification of active compounds was conducted by a bio-guided fractionation of the extract that afforded 16 fractions. Fraction J exhibited a concentration-dependent inhibitory activity on the NF-κB driven transcription and significantly contributed to the antiphlogistic effect showed by CH2Cl2 extract. The main components of fraction J were loliolide and the fucoside acetates of β-eudesmol and viridiflorol. HPLC analysis of fractions D and E led to the identification and isolation of triterpene esters that showed a concentration-dependent inhibition of the NF-κB driven transcription, with faradiol-3-myristate and the corresponding aglycone being the most active compounds. The present study provides some experimental evidences that Calendula officinalis L. may exert an anti-inflammatory activity on the gastric district by the inhibition of the NF-κB system, identifying the compounds responsible, at least in part, for the observed effect.

  2. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies Bark by-Products and Investigation of Their Dermo-Cosmetic Properties

    Directory of Open Access Journals (Sweden)

    Apostolis Angelis

    2016-11-01

    Full Text Available Common spruce (Picea abies L. is a fast-growing coniferous tree, widely used in several countries for the production of sawn wood, timber and pulp. During this industrial exploitation, large quantities of barks are generated as waste materials. The aim of this study was the bio-guided investigation and the effective recovery of methanol-soluble metabolites of common spruce bark for the development of new dermo-cosmetic agents. The active methanol extract was initially fractionated by Centrifugal Partition Chromatography (CPC using a triphasic solvent system in a step-gradient elution mode. All resulting fractions were evaluated for their antibacterial activity, antioxidant activity and their capability to inhibit tyrosinase, elastase and collagenase activity. In parallel, the chemical composition of each fraction was established by combining a 13C-NMR dereplication approach and 2D-NMR analyses. As a result, fourteen secondary metabolites corresponding to stilbene, flavonoid and phenolic acid derivatives were directly identified in the CPC fractions. A high amount (0.93 g of E-astringin was recovered from 3 g of crude extract in a single 125 min run. E-Astringin significantly induced the tyrosinase activity while E-piceid, taxifolin, and taxifolin-3′-O-glucopyranoside exhibited significant anti-tyrosinase activity. The above compounds showed important anti-collagenase and antimicrobial activities, thus providing new perspectives for potential applications as cosmetic ingredients.

  3. Chandra Discovers Cosmic Cannonball

    Science.gov (United States)

    2007-11-01

    One of the fastest moving stars ever seen has been discovered with NASA's Chandra X-ray Observatory. This cosmic cannonball is challenging theories to explain its blistering speed. Astronomers used Chandra to observe a neutron star, known as RX J0822-4300, over a period of about five years. During that span, three Chandra observations clearly show the neutron star moving away from the center of the Puppis A supernova remnant. This remnant is the stellar debris field created during the same explosion in which the neutron star was created about 3700 years ago. Chandra X-ray Image of RX J0822-4300 in Puppis A Chandra X-ray Image of RX J0822-4300 in Puppis A By combining how far it has moved across the sky with its distance from Earth, astronomers determined the neutron star is moving at over 3 million miles per hour. At this rate, RX J0822-4300 is destined to escape from the Milky Way after millions of years, even though it has only traveled about 20 light years so far. "This star is moving at 3 million miles an hour, but it's so far away that the apparent motion we see in five years is less than the height of the numerals in the date on a penny, seen from the length of a football field," said Frank Winkler of Middlebury College in Vermont. "It's remarkable, and a real testament to the power of Chandra, that such a tiny motion can be measured." Labeled Image of RX J0822-4300 in Puppis A Labeled Image of RX J0822-4300 in Puppis A "Just after it was born, this neutron star got a one-way ticket out of the Galaxy," said co-author Robert Petre of NASA's Goddard Space Flight Center in Greenbelt, Md. "Astronomers have seen other stars being flung out of the Milky Way, but few as fast as this." So-called hypervelocity stars have been previously discovered shooting out of the Milky Way with speeds around one million miles per hour. One key difference between RX J0822-4300 and these other reported galactic escapees is the source of their speed. The hypervelocity stars are

  4. Lightest exoplanet yet discovered

    Science.gov (United States)

    2009-04-01

    Well-known exoplanet researcher Michel Mayor today announced the discovery of the lightest exoplanet found so far. The planet, "e", in the famous system Gliese 581, is only about twice the mass of our Earth. The team also refined the orbit of the planet Gliese 581 d, first discovered in 2007, placing it well within the habitable zone, where liquid water oceans could exist. These amazing discoveries are the outcome of more than four years of observations using the most successful low-mass-exoplanet hunter in the world, the HARPS spectrograph attached to the 3.6-metre ESO telescope at La Silla, Chile. ESO PR Photo 15a/09 Artist's impression of Gliese 581 e ESO PR Photo 15b/09 A planet in the habitable zone ESO PR Video 15a/09 ESOcast 6 ESO PR Video 15b/09 VNR A-roll ESO PR Video 15c/09 Zoom-in on Gliese 581 e ESO PR Video 15d/09 Artist's impression of Gliese 581 e ESO PR Video 15e/09 Artist's impression of Gliese 581 d ESO PR Video 15f/09 Artist's impression of Gliese 581 system ESO PR Video 15g/09 The radial velocity method ESO PR Video 15h/09 Statement in English ESO PR Video 15i/09 Statement in French ESO PR Video 15j/09 La Silla Observatory "The holy grail of current exoplanet research is the detection of a rocky, Earth-like planet in the ‘habitable zone' -- a region around the host star with the right conditions for water to be liquid on a planet's surface", says Michel Mayor from the Geneva Observatory, who led the European team to this stunning breakthrough. Planet Gliese 581 e orbits its host star - located only 20.5 light-years away in the constellation Libra ("the Scales") -- in just 3.15 days. "With only 1.9 Earth-masses, it is the least massive exoplanet ever detected and is, very likely, a rocky planet", says co-author Xavier Bonfils from Grenoble Observatory. Being so close to its host star, the planet is not in the habitable zone. But another planet in this system appears to be. From previous observations -- also obtained with the HARPS spectrograph

  5. Discovering Natural Laws by Reduction

    Institute of Scientific and Technical Information of China (English)

    吴轶华

    1989-01-01

    A polynomial algorithm.called Reduction,is presented to discover natural laws by analysing a set of experimental data.instead of a heuristic exploration which,when adopted in BACON,can only lead to rediscovering simple laws.A complex law with multiple variables involved can be discovered by reducing it to a search.This search is so efficient that it does not need any backtracking and is able to cover most of possible laws.A reduction-based discovery system,called DISCOVER 2.0,was developed with a flexible knowledge base and an ability of dealing with imperfect data.The system has been verified to be valid computationally,practically,and theoretically,by discovering a great number o complex laws,and can be also viewed as a leaming engine embodied in any intelligent systems to improve their performance by obtaining a general rule from the accumulated data.

  6. Discover: What Is Public Health?

    Science.gov (United States)

    ... Series Undergraduate Network Membership Contact Discover What is Public Health? Public health protects and improves the health of individuals, families, communities, and populations, locally and globally. Public health is personal. Public health professionals focus on preventing ...

  7. Discovering Relationships Involving Baravelle Spirals

    Science.gov (United States)

    Wanko, Jeffrey J.

    2006-01-01

    This article details an exploration of Baravelle spirals as visual representations of infinite geometric series, focusing on a variety of strategies used by preservice teachers in discovering patterns and investigating relationships of variables.

  8. Site Location Details, Air Pollution Monitoring Equipment Used, Aircraft Flight Path Information, and Deployment Configuration for the DISCOVER-AQ (Deriving Information on Surface Conditions from COlumn and VERtically Resolved Observations Relevant to Air Quality) Field Campaign in Colorado: Summer 2014

    Science.gov (United States)

    For EPA, this Summer 2014, Denver CO, DISCOVER-AQ field research activity focused on assessing Federal Reference Methods (FRMs) and Federal Equivalent Methods (FEMs) for ozone (O3) and Nitrogen Dioxide (NO2), while comparing their operational performance to each other and to smal...

  9. Discovering High Fashion in Beijing

    Institute of Scientific and Technical Information of China (English)

    MARTHA; KANG; MCGILL

    2006-01-01

    Nothing beats bargaining in a Beijing clothes market. As an American student, it's a completely novel experience, a great way to practice your Chinese, and gives you the feeling of discovering the real Beijing. The atmosphere is so different from shopping experiences in the United States. It seems here that it must be authentic con

  10. Scientists Discover Sugar in Space

    Science.gov (United States)

    2000-06-01

    . Glycolaldehyde is a simpler molecular cousin to table sugar, the scientists say. The sugar molecule was detected in a large cloud of gas and dust some 26,000 light-years away, near the center of our Galaxy. Such clouds, often many light-years across, are the material from which new stars are formed. Though very rarified by Earth standards, these interstellar clouds are the sites of complex chemical reactions that occur over hundreds of thousands or millions of years. So far, about 120 different molecules have been discovered in these clouds. Most of these molecules contain a small number of atoms, and only a few molecules with eight or more atoms have been found in interstellar clouds. The 12 Meter Telescope "Finding glycolaldehyde in one of these interstellar clouds means that such molecules can be formed even in very rarified conditions," said Hollis. "We don't yet understand how it could be formed there," he added. "A combination of more astronomical observations and theoretical chemistry work will be required to resolve the mystery of how this molecule is formed in space." "We hope this discovery inspires renewed efforts to find even more kinds of molecules, so that, with a better idea of the total picture, we may be able to deduce the details of the prebiotic chemistry taking place in interstellar clouds," Hollis said. The discovery was made by detecting faint radio emission from the sugar molecules in the interstellar cloud. Molecules rotate end-for-end, and as they change from one rotational energy state to another, they emit radio waves at precise frequencies. The "family" of radio frequencies emitted by a particular molecule forms a unique "fingerprint" that scientists can use to identify that molecule. The scientists identified glycolaldehyde by detecting six frequencies of radio emission in what is termed the millimeter-wavelength region of the electromagnetic spectrum -- a region between more-familiar microwaves and infrared radiation. The NRAO 12 Meter Telescope

  11. Who discovered the magnetocaloric effect?

    DEFF Research Database (Denmark)

    Smith, Anders

    2013-01-01

    A magnetic body changes its thermal state when subjected to a changing magnetic field. In particular, if done under adiabatic conditions, its temperature changes. For the past 15 years the magnetocaloric effect has been the focus of significant research due to its possible application for efficient...... refrigeration near room temperature. At the same time, it has become common knowledge within the magnetic refrigeration research community that the magnetocaloric effect was discovered by the German physicist E. Warburg in 1881. We re-examine the original literature and show that this is a misleading reading...

  12. Discovering evolution equations with applications

    CERN Document Server

    McKibben, Mark

    2011-01-01

    Most existing books on evolution equations tend either to cover a particular class of equations in too much depth for beginners or focus on a very specific research direction. Thus, the field can be daunting for newcomers to the field who need access to preliminary material and behind-the-scenes detail. Taking an applications-oriented, conversational approach, Discovering Evolution Equations with Applications: Volume 2-Stochastic Equations provides an introductory understanding of stochastic evolution equations. The text begins with hands-on introductions to the essentials of real and stochast

  13. Ultrahigh spatiotemporal resolved spectroscopy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ We review the technique and research of the ultrahigh spatiotemporal resolved spectroscopy and its applications in the field of the ultrafast dynamics of mesoscopic systems and nanomaterials. Combining femtosecond time-resolved spectroscopy and scanning near-field optical microscopy (SNOM), we can obtain the spectra with ultrahigh temporal and spatial resolutions simultaneously. Some problems in doing so are discussed. Then we show the important applications of the ultrahigh spatiotemporal resolved spectroscopy with a few typical examples.

  14. Ultrahigh spatiotemporal resolved spectroscopy

    Institute of Scientific and Technical Information of China (English)

    LI; Zhi

    2007-01-01

    We review the technique and research of the ultrahigh spatiotemporal resolved spectroscopy and its applications in the field of the ultrafast dynamics of mesoscopic systems and nanomaterials. Combining femtosecond time-resolved spectroscopy and scanning near-field optical microscopy (SNOM), we can obtain the spectra with ultrahigh temporal and spatial resolutions simultaneously. Some problems in doing so are discussed. Then we show the important applications of the ultrahigh spatiotemporal resolved spectroscopy with a few typical examples.……

  15. Discovering Mobile Social Networks by Semantic Technologies

    Science.gov (United States)

    Jung, Jason J.; Choi, Kwang Sun; Park, Sung Hyuk

    It has been important for telecommunication companies to discover social networks from mobile subscribers. They have attempted to provide a number of recommendation services, but they realized that the services were not successful. In this chapter, we present semantic technologies for discovering social networks. The process is mainly composed of two steps; (1) profile identification and (2) context understanding. Through developing a Next generation Contents dElivery (NICE) platform, we were able to generate various services based on the discovered social networks.

  16. Discovering Classes of Strongly Equivalent Logic Programs

    OpenAIRE

    Chen, Y.; Lin, F.

    2011-01-01

    In this paper we apply computer-aided theorem discovery technique to discover theorems about strongly equivalent logic programs under the answer set semantics. Our discovered theorems capture new classes of strongly equivalent logic programs that can lead to new program simplification rules that preserve strong equivalence. Specifically, with the help of computers, we discovered exact conditions that capture the strong equivalence between a rule and the empty set, between two rules, between t...

  17. Probable Bright Supernova discovered by PSST

    Science.gov (United States)

    Smith, K. W.; Wright, D.; Smartt, S. J.; Young, D. R.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-09-01

    A bright transient, which is a probable supernova, has been discovered as part of the Pan-STARRS Survey for Transients (PSST). Information on all objects discovered by the Pan-STARRS Survey for Transients is available at http://star.pst.qub.ac.uk/ps1threepi/ (see Huber et al. ATel #7153).

  18. Scientists Discover More Clues to Stuttering

    Science.gov (United States)

    ... fullstory_162368.html Scientists Discover More Clues to Stuttering MRI shows involvement of brain areas controlling speech, ... speech, attention and emotion are all linked to stuttering. Stuttering is characterized by involuntarily repeating certain sounds, ...

  19. Resolving Disputes in Education.

    Science.gov (United States)

    Seeley, Kenneth R.; Schrant, Nancy E.

    Because of the increasing incidence of disputes in schools, educators need more knowledge about methods of dispute resolution. The adversary system of resolving disputes, on which the U.S. judicial system is founded, assumes that truth is best found through a struggle between two opposing parties. In the adversary system, due process plays a…

  20. Resolved SZE Cluster Count

    Institute of Scientific and Technical Information of China (English)

    Jia-Yu Tang; Zu-Hui Fan

    2003-01-01

    We study the counts of resolved SZE (Sunyaev-Zel'dovich effect) clus-ters expected from an interferometric survey in different cosmological models underdifferent conditions. The self-similar universal gas model and Press-Schechter massfunction are used. We take the observing frequency to be 90 GHz, and consider twodish diameters, 1.2 m and 2.5 m. We calculate the number density of the galaxyclusters dN/(dΩdz) at a high flux limit Slimv = 100mJy and at a relative lowSlimv = 10 mJy. The total numbers of SZE clusters N in two low-Ω0 models arecompared. The results show that the influence of the resolved effect depends notonly on D, but also on Slimv: at a given D, the effect is more significant for a highthan for a low Slim Also, the resolved effect for a flat universe is more impressivethan that for an open universe. For D = 1.2m and Slimv= 10mJy, the resolvedeffect is very weak. Considering the designed interferometers which will be used tosurvey SZE clusters, we find that the resolved effect is insignificant when estimatingthe expected yield of the SZE cluster surveys.

  1. Resolving-Power Quantization

    CERN Document Server

    Neuberger, Herbert

    2016-01-01

    Starting with a general discussion, a program is sketched for a quantization based on dilations. This resolving-power quantization is simplest for scalar field theories. The hope is to find a way to relax the requirement of locality so that the necessity to fine tune mass parameters is eliminated while universality is still preserved.

  2. Discovering More Accurate Frequent Web Usage Patterns

    CERN Document Server

    Bayir, Murat Ali; Cosar, Ahmet; Fidan, Guven

    2008-01-01

    Web usage mining is a type of web mining, which exploits data mining techniques to discover valuable information from navigation behavior of World Wide Web users. As in classical data mining, data preparation and pattern discovery are the main issues in web usage mining. The first phase of web usage mining is the data processing phase, which includes the session reconstruction operation from server logs. Session reconstruction success directly affects the quality of the frequent patterns discovered in the next phase. In reactive web usage mining techniques, the source data is web server logs and the topology of the web pages served by the web server domain. Other kinds of information collected during the interactive browsing of web site by user, such as cookies or web logs containing similar information, are not used. The next phase of web usage mining is discovering frequent user navigation patterns. In this phase, pattern discovery methods are applied on the reconstructed sessions obtained in the first phas...

  3. A Bayesian Model for Discovering Typological Implications

    CERN Document Server

    Daumé, Hal

    2009-01-01

    A standard form of analysis for linguistic typology is the universal implication. These implications state facts about the range of extant languages, such as ``if objects come after verbs, then adjectives come after nouns.'' Such implications are typically discovered by painstaking hand analysis over a small sample of languages. We propose a computational model for assisting at this process. Our model is able to discover both well-known implications as well as some novel implications that deserve further study. Moreover, through a careful application of hierarchical analysis, we are able to cope with the well-known sampling problem: languages are not independent.

  4. Discovering English with the Sketch Engine

    Science.gov (United States)

    Thomas, James

    2014-01-01

    "Discovering English with the Sketch Engine" is the title of a new book (Thomas, 2014) which introduces the use of corpora in language study, teaching, writing and translating. It focuses on using the Sketch Engine to identify patterns of normal usage in many aspects of English ranging from morphology to discourse and pragmatics. This…

  5. MASTER: bright PSN discovered in Argentina

    Science.gov (United States)

    Shumkov, V.; Lipunov, V.; Podesta, R.; Levato, H.; Buckley, D.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kuznetsov, A.; Vladimirov, V.; Gress, O.; Ivanov, K.; Chazov, V.; Lopez, C.; Podesta, F.; Saffe, C.; Pogrosheva, T.; Shurpakov, S.

    2016-10-01

    MASTER-OAFA (located in Argentina) auto-detection system ( Lipunov et al., 2010, Advances in Astronomy, vol. 2010, 30L ) discovered OT source at (RA, Dec) = 22h 01m 01.36s -40d 15m 26.7s on 2016-10-31.08091 UT. The OT unfiltered magnitude is 16.9m (mlim=19.9m).

  6. Discovering the Sequential Structure of Thought

    Science.gov (United States)

    Anderson, John R.; Fincham, Jon M.

    2014-01-01

    Multi-voxel pattern recognition techniques combined with Hidden Markov models can be used to discover the mental states that people go through in performing a task. The combined method identifies both the mental states and how their durations vary with experimental conditions. We apply this method to a task where participants solve novel…

  7. New volcanoes discovered in southeast Australia

    Science.gov (United States)

    Wendel, JoAnna

    2014-07-01

    Scientists have discovered three new active volcanoes in the Newer Volcanics Province (NVP) in southeast Australia. Researchers from Monash University in Melbourne describe in the Australian Journal of Earth Sciences how they used a combination of satellite photographs, detailed topography models from NASA, the distribution of magnetic minerals in the rocks, and site visits to analyze the region.

  8. Digging Deeper: Looking Beyond Behavior to Discover Meaning

    Medline Plus

    Full Text Available ... Behavior to Discover Meaning A Unit of Four Online Lessons Digging Deeper: Looking Beyond Behavior to Discover ... Behavior to Discover Meaning. A Unit of Four Online Lessons. HHS/ACF/OHS/EHSNRC. 2006. English. Last ...

  9. Discovering Recurrent Image Semantics from Class Discrimination

    Directory of Open Access Journals (Sweden)

    Jin Jesse S

    2006-01-01

    Full Text Available Supervised statistical learning has become a critical means to design and learn visual concepts (e.g., faces, foliage, buildings, etc. in content-based indexing systems. The drawback of this approach is the need of manual labeling of regions. While several automatic image annotation methods proposed recently are very promising, they usually rely on the availability and analysis of associated text descriptions. In this paper, we propose a hybrid learning framework to discover local semantic regions and generate their samples for training of local detectors with minimal human intervention. A multiscale segmentation-free framework is proposed to embed the soft presence of discovered semantic regions and local class patterns in an image independently for indexing and matching. Based on 2400 heterogeneous consumer images with 16 semantic queries, both similarity matching based on individual index and integrated similarity matching have outperformed a feature fusion approach by 26% and 37% in average precisions, respectively.

  10. Resolvability in Circulant Graphs

    Institute of Scientific and Technical Information of China (English)

    Muhammad SALMAN; Imran JAVAID; Muhammad Anwar CHAUDHRY

    2012-01-01

    A set W of the vertices of a connected graph G is called a resolving set for G if for every two distinct vertices u,v ∈ V(G) there is a vertex w ∈ W such that d(u,w) ≠ d(v,w).A resolving set of minimum cardinality is called a metric basis for G and the number of vertices in a metric basis is called the metric dimension of G,denoted by dim(G).For a vertex u of G and a subset S of V(G),the distance between u and S is the number mins∈s d(u,s).A k-partition H ={S1,S2,...,Sk} of V(G) is called a resolving partition if for every two distinct vertices u,v ∈ V(G) there is a set Si in Π such that d(u,Si) ≠ d(v,Si).The minimum k for which there is a resolving k-partition of V(G) is called the partition dimension of G,denoted by pd(G).The circulant graph is a graph with vertex set Zn,an additive group ofintegers modulo n,and two vertices labeled i and j adjacent if and only if i - j (mod n) ∈ C,where C C Zn has the property that C =-C and 0(∈) C.The circulant graph is denoted by Xn,△ where A =|C|.In this paper,we study the metric dimension of a family of circulant graphs Xn,3 with connection set C ={1,-n/2,n - 1} and prove that dim(Xn,3) is independent of choice of n by showing that 3 for all n =0 (mod 4),dim(X,n,3) ={ 4 for all n =2 (mod 4).We also study the partition dimension of a family of circulant graphs Xn,4 with connection set C ={±1,±2} and prove that pd(Xn,4) is independent of choice of n and show that pd(X5,4) =5 and 3 forall odd n≥9,pd(Xn,4) ={ 4 for all even n ≥ 6 and n =7.

  11. MASTER: 2 OT discovered in Argentina

    Science.gov (United States)

    Shumkov, V.; Pogrosheva, T.; Lipunov, V.; Podesta, R.; Levato, H.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kuznetsov, A.; Vladimirov, V.; Gress, O.; Ivanov, K.; Chazov, V.; Lopez, C.; Podesta, F.; Saffe, C.

    2016-10-01

    MASTER-OAFA, located in Argentina, with auto-detection system (Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L) discovered OT source at (RA, Dec) = 03h 19m 42.92s -45d 30m 13.9s on 2016-10-27.27597 UT. The OT unfiltered magnitude is 16.9m (mlim=20.8m).

  12. Transpleural central venous catheter discovered during thoracotomy

    Directory of Open Access Journals (Sweden)

    Ashima Malhotra

    2014-01-01

    Full Text Available We report an uncommon complication of subclavian central venous catheterization, discovered at thoracotomy. The central venous catheter (CVC was placed by left infraclavicular route after induction of general anesthesia. CVC was secured after aspiration of blood and satisfactory central venous tracing. On thoracotomy, CVC was noticed to traverse the pleural cavity while the tracing was normal. CVC was thus removed consequent to which bleeding from each puncture site was noticed, that were secured surgically.

  13. “Fine-Scale Application of the coupled WRF-CMAQ System to the 2011 DISCOVER-AQ Campaign”

    Science.gov (United States)

    The DISCOVER-AQ project (Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality), is a joint collaboration between NASA, U.S. EPA and a number of other local organizations with the goal of characterizing air quality in ...

  14. Discovering Attack Path Oriented-IP Traceback

    Institute of Scientific and Technical Information of China (English)

    Fu Jianming(傅建明); Zhu Fuxi; Peng Guojun

    2003-01-01

    The technique of IP traceback may effectively block DOS (Denial Of Service) and meet the requirement of the computer forensic, but its accuracy depends upon that condition that each node in the Internet must support IP packet marking or detected agents. So far, this requirement is not satisfied. On the basis of traditional traceroute,this paper investigates the efficiency of discovering path methods from aspects of the size and order of detecting packets, and the length of paths.It points out that the size of padding in probed packets has a slight effect on discovering latency, and the latency with the method of bulk sending-receiving is much smaller than one with the traditional traceroute. Moreover, the loss rate of packets with the technique of TTL (Time To Live) which increases monotonously is less than that with the technique of TTL which decreases monotonously. Lastly,OS (Operating System) passive fingerprint is used as heuristic to predict the length of the discovered path so as to reduce disturbance in network traffic.

  15. What if Fleming had not discovered penicillin?

    Science.gov (United States)

    Alharbi, Sulaiman Ali; Wainwright, Milton; Alahmadi, Tahani Awad; Salleeh, Hashim Bin; Faden, Asmaa A; Chinnathambi, Arunachalam

    2014-09-01

    What would have happened had Alexander Fleming not discovered penicillin in 1928? Perhaps the obvious answer is that, someone else would have discovered penicillin during 1930s and the Oxford group, would still have purified it sometime in the early 1940s. Here, however, in this counterfactual account of the penicillin story, it is argued that without Fleming, penicillin might still be undiscovered and the antibiotic age would never have dawned. As a result, many of the recent developments in medicine, such as organ transplantation, might have been delayed or, at best, made more hazardous. Penicillin might have come onto the scene a few years later but, had Fleming overlooked the discovery, it seems certain that penicillin would not have saved countless Allied lives, during and after D-Day. Instead of having enjoyed fifty and more years of the antibiotic age, it is argued here, that we would have had to rely upon highly developed sulphonamides, so-called "supasulfas", and other chemically-derived antibacterial drugs. Indeed, it might be the case that, even well into this new millennium, the antibiotic age has yet to dawn, and medicine is still waiting for someone to chance upon penicillin. Here we discuss what might have happened had Fleming not discovered penicillin and come to the conclusion that the medical armoury available today would have been far different and might have relied solely upon highly developed varieties of sulphonamides or similar, synthetic, non-antibiotic antibacterial agents.

  16. Discovering Typed Communities in Mobile Social Networks

    Institute of Scientific and Technical Information of China (English)

    Huai-Yu Wan; You-Fang Lin; Zhi-Hao Wu; Hou-Kuan Huang

    2012-01-01

    Mobile social networks,which consist of mobile users who communicate with each other using cell phones,are reflections of people's interactions in social lives.Discovering typed communities (e.g.,family communities or corporate communities) in mobile social networks is a very promising problem.For example,it can help mobile operators to determine the target users for precision marketing.In this paper we propose discovering typed communities in mobile social networks by utilizing the labels of relationships between users.We use the user logs stored by mobile operators,including communication and user movement records,to collectively label all the relationships in a network,by employing an undirected probabilistic graphical model,i.e.,conditional random fields.Then we use two methods to discover typed communities based on the results of relationship labeling:one is simply retaining or cutting relationships according to their labels,and the other is using sophisticated weighted community detection algorithms.The experimental results show that our proposed framework performs well in terms of the accuracy of typed community detection in mobile social networks.

  17. Brief resolved unexplained event

    Science.gov (United States)

    Arane, Karen; Claudius, Ilene; Goldman, Ran D.

    2017-01-01

    Abstract Question For many years, the term apparent life-threatening event (ALTE) was associated with sudden infant death syndrome, and parents who described an acute event in their infants were sent to the hospital for admission. I understand that for infants new terminology is recommended. What is the current approach to a near-death experience of an infant? Answer A recent clinical practice guideline revised the name and definition of an ALTE to a brief resolved unexplained event (BRUE). The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following BRUE symptoms: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination are completed, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness. Low-risk infants should not be admitted to the hospital and overtesting is discouraged. PMID:28115439

  18. A guide to resolving disputes over defective specifications

    OpenAIRE

    Wirsching, Steven M.

    1992-01-01

    CIVINS Approved for public release; distribution is unlimited. This thesis investigated the legal criteria involved in resolving defective specification disputes. Appellate case law was researched to discover the rules used by the court systems to decide cases involving defective specifications. These rules were organized in flowchart form to provide a guide for construction contract administrators. Separate flow charts were prepared for method and performance specifications, and the di...

  19. Dinosaur Footprint Fossils Discovered in Xinjiang

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Recently,a Chinese-German science fieldwork investigation team,composed of staff from the SinoGerman Paleontology and Geography Joint Lab and the Xinjiang Geological Work Station,announced that they discovered a batch of dinosaur footprint fossils in the dessert 20 kilometers to the east of Shanshan County in the Turpan Basin,Xinjiang Uyghur Autonomous Region.These fossils spread around an area of 100 square meters and scientists believed that these footprints were left behind by carnivore dinosaurs.This major discovery has been published in Global Geology,an English journal published by the NorthEast Asia Geology Center.

  20. The Universe for all to discover

    Science.gov (United States)

    Ortiz-Gil, A.; Ballesteros, F.; Espinós, H.; Fernández-Soto, A.; Lanzara, M.; Moya, M. J.; Navarro, J.

    2015-05-01

    In the title of this paper, we have changed the slogan of the International Year of Astronomy, ``The Universe yours to discover" to ``The Universe for all to discover" in order to emphasize the need to think about broader audiences when we plan astronomical activities at school or during outreach events. The strategy we propose follows what is known as the Universal Design for Learning (UDL). UDL allows to reach to the general public as well as to audiences which might be regarded as ``special" because they have some disability. It has been shown that everybody has a preferred style of learning (some remember better what they see, others what they hear or what they touch) and therefore, everybody is more or less able under the different styles of learning. Through this talk I am going to outline some of the principles of the UDL that can be applied in the teaching and communication of Astronomy, along with an example of its implementation in the project ``A Touch of the Universe".

  1. Recently discovered pulsars and unidentified EGRET sources

    CERN Document Server

    Torres, D F; Camilo, F M; Torres, Diego F.; Butt, Yousaf M.; Camilo, Fernando

    2001-01-01

    We present a correlative study between all unidentified EGRET sources at low Galactic latitudes and the newly discovered pulsars in the released portion of the Parkes multibeam radio survey. We note 14 positional coincidences: eight of these are ``Vela-like'' pulsars, with relatively small periods, small characteristic ages, and high spin-down luminosities. Three of these coincidences have been investigated by D'Amico et al. (2001) and Camilo et al. (2001). Among the others, we argue that PSR J1015-5719 may plausibly generate part of the high energy radiation observed from 3EG J1014-5705. Three additional interesting cases are: 3EG J1410-6147 and either of PSRs J1412-6145 or J1413-6141, if the pulsars are at the estimated distance of the coincident SNR G312.4-0.4; and 3EG J1639-4702/PSR J1637-4642. The remaining positional coincidences between the EGRET sources and the newly discovered pulsars are almost certainly spurious.

  2. Challenges and opportunities for remote sensing of air quality: Insights from DISCOVER-AQ

    Science.gov (United States)

    Crawford, J. H.; Pickering, K. E.; Anderson, B. E.; Beyersdorf, A. J.; Clark, R. D.; Cohen, R. C.; Diskin, G. S.; Ferrare, R. A.; Fried, A.; Holben, B. N.; Herman, J. R.; Hoff, R. M.; Hostetler, C. A.; Janz, S. J.; Szykman, J.; Thompson, A. M.; Weinheimer, A. J.; Wisthaler, A.; Yang, M. M.; Chen, G.; Kleb, M. M.

    2014-12-01

    Improving the remote sensing of air quality has been the primary focus of a series of four field studies conducted by a project called DISCOVER-AQ (Deriving Information on Surface conditions from COlumn and VERtically resolved observations relevant to Air Quality). Operating as an integrated observing system, DISCOVER-AQ has employed multiple aircraft and ground instrumentation to conduct multi-perspective observations of the distribution of gaseous and particulate pollution in the lower atmosphere over contrasting regions of the U.S. that are currently in violation of National Ambient Air Quality Standards. The four study areas include Maryland (Baltimore-Washington corridor), California (southern San Joaquin Valley), Texas (Greater Houston area), and Colorado (Denver/Northern Front Range). The DISCOVER-AQ observations are actively being used to promote improvements in remote sensing in the following ways: Characterizing vertical structure in the atmosphere and its diurnal patterns to develop improved a priori information for satellite retrievals; Examining horizontal variability to assess the spatial scales needed to resolve emissions and photochemistry; Determining correlative relationships between remotely sensed and in situ observations; Assessing the value of ground-based remote sensing to provide information on impact of boundary layer dynamics and mixing on air pollution. Examples of the ongoing analysis of these datasets and their relevance to future geostationary satellite observations as well as augmentation of air quality monitoring networks with ground-based remote sensing will be discussed.

  3. Discovering chemistry with an ab initio nanoreactor

    Science.gov (United States)

    Wang, Lee-Ping; Titov, Alexey; McGibbon, Robert; Liu, Fang; Pande, Vijay S.; Martínez, Todd J.

    2014-12-01

    Chemical understanding is driven by the experimental discovery of new compounds and reactivity, and is supported by theory and computation that provide detailed physical insight. Although theoretical and computational studies have generally focused on specific processes or mechanistic hypotheses, recent methodological and computational advances harken the advent of their principal role in discovery. Here we report the development and application of the ab initio nanoreactor—a highly accelerated first-principles molecular dynamics simulation of chemical reactions that discovers new molecules and mechanisms without preordained reaction coordinates or elementary steps. Using the nanoreactor, we show new pathways for glycine synthesis from primitive compounds proposed to exist on the early Earth, which provide new insight into the classic Urey-Miller experiment. These results highlight the emergence of theoretical and computational chemistry as a tool for discovery, in addition to its traditional role of interpreting experimental findings.

  4. Discovering User Profiles for Web Personalized Recommendation

    Institute of Scientific and Technical Information of China (English)

    Ai-Bo Song; Mao-Xian Zhao; Zuo-Peng Liang; Yi-Sheng Dong; Jun-Zhou Luo

    2004-01-01

    With the growing popularity of the World Wide Web, large volume of user access data has been gathered automatically by Web servers and stored in Web logs. Discovering and understanding user behavior patterns from log files can provide Web personalized recommendation services. In this paper, a novel clustering method is presented for log files called Clustering large Weblog based on Key Path Model (CWKPM), which is based on user browsing key path model, to get user behavior profiles. Compared with the previous Boolean model,key path model onsiders the major features of users' accessing to the Web: ordinal, contiguous and duplicate.Moreover, for clustering, it has fewer dimensions. The analysis and experiments show that CWKPM is an efficient and effective approach for clustering large and high-dimension Web logs.

  5. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A.Immaculate Mercy

    2014-01-01

    Full Text Available This work introduces a link analysis procedure for discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the rela ted protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The e lements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  6. Discovering and Mining Links for Protein Databases

    Directory of Open Access Journals (Sweden)

    A. Immaculate Mercy

    2015-10-01

    Full Text Available discovering relationships in a protein database or a relational database generalizing simple correspondence analysis. It is based on extracting the links to the related protein database and malfunctioned protein database. The datasets are trained in order to find out missing interactions and the sequences related to them. Further the analysis of links proceeds by performing a random walk defining a Markov chain. The elements of interest are analysed through stochastic complementation which gives a reduced Markov chain. This reduced map is then analysed by projecting the elements of interest through Principal component analysis. Several Protein datasets are analysed using the proposed methodology, showing the usefulness of the technique for extracting relationships in relational databases or graphs.

  7. Discovering New Drugs on the Cellular Level

    Science.gov (United States)

    2005-01-01

    With the Vision for Space Exploration calling for a sustained human presence in space, astronauts will need to grow plants, while in orbit, for nourishment that they will not receive from only consuming dehydrated foods. As a potential source of food for long-duration missions, space-grown plants could also give astronauts an important psychological boost, as fresh vegetables could serve as a welcomed change from monotonous meals consisting of reconstituted foods in plastic bags. Even more, these plants could likely aid in the recycling of air and wastewater on spacecraft. With a helping hand from a company by the name of Biolog, Inc., NASA is studying the impacts of decreased gravity and spaceborne bacteria on the plants being grown for food in space. With a helping hand from NASA, this very same company is creating powerful new cell- and bacteria-analysis tools for use in discovering and developing new drugs on Earth.

  8. Discovering User Profiles for Web Personalized Recommendation

    Institute of Scientific and Technical Information of China (English)

    Ai-BoSong; Mao-XianZhao; Zuo-PengLiang; Yi-ShengDong; Jun-ZhouLuo

    2004-01-01

    With the growing popularity of the World Wide Web, large volume of user access data has been gathered automatically by Web servers and stored in Web logs. Discovering and understanding user behavior patterns from log files can provide Web personalized recommendation services. In this paper, a novel clustering method is presented for log files called Clustering large Weblog based on Key Path Model (CWKPM), which is based on user browsing key path model, to get user behavior profiles. Compared with the previous Boolean model, key path model considers the major features of users' accessing to the Web: ordinal, contiguous and duplicate. Moreover, for clustering, it has fewer dimensions. The analysis and experiments show that CWKPM is an efficient and effective approach for clustering large and high-dimension Web logs.

  9. Michael Maier--nine newly discovered letters.

    Science.gov (United States)

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  10. Discovering general partial orders in event streams

    CERN Document Server

    Achar, Avinash; Raajay, V; Sastry, P S

    2009-01-01

    Sequence of time-ordered events arise in a variety of applications like customer transaction databases, alarm sequences in telecommunication networks, fault logs in manufacturing plant data, web interaction logs, etc. A popular framework for temporal pattern extraction from such data is the frequent episode discovery paradigm. An episode is a set of nodes with a partial order prescribed on it, with each node associated with an event type. Efficient algorithms exist for episode discovery when the associated partial order is total(serial episode) or trivial(parallel episode). In this paper, we propose efficient algorithms for discovering frequent episodes with general partial orders. The algorithms generalize the existing apriori-based discovery algorithms for serial and parallel episodes. There is an inherent combinatorial explosion in frequent partial order mining. We point out that frequency alone is not a sufficient measure of interestingness for general episodes. We present post-processing techniques to pr...

  11. The discovered preference hypothesis - an empirical test

    DEFF Research Database (Denmark)

    Lundhede, Thomas; Ladenburg, Jacob; Olsen, Søren Bøye

    an nterpretation and explanation of biases which entails that the stated preference methods need not to be completely written off. In this paper we conduct a test for the validity and relevance of the DPH interpretation of biases. In a choice experiment concerning preferences for protection of Danish nature areas...... from new motorway development, we find that respondent preferences are susceptible to starting point bias. In particular, our results show that the bias is gender-specific as only female respondents are significantly biased. Importantly, we find that the impact of the starting point bias decays......Using stated preference methods for valuation of non-market goods is known to be vulnerable to a range of biases. Some authors claim that these so-called anomalies in effect render the methods useless for the purpose. However, the Discovered Preference Hypothesis, as put forth by Plott [31], offers...

  12. Discovering Rules by Meta-level Abduction

    Science.gov (United States)

    Inoue, Katsumi; Furukawa, Koichi; Kobayashi, Ikuo; Nabeshima, Hidetomo

    This paper addresses discovery of unknown relations from incomplete network data by abduction. Given a network information such as causal relations and metabolic pathways, we want to infer missing links and nodes in the network to account for observations. To this end, we introduce a framework of meta-level abduction, which performs abduction in the meta level. This is implemented in SOLAR, an automated deduction system for consequence finding, using a first-order representation for algebraic properties of causality and the full-clausal form of network information and constraints. Meta-level abduction by SOLAR is powerful enough to infer missing rules, missing facts, and unknown causes that involve predicate invention in the form of existentially quantified hypotheses. We also show an application of rule abduction to discover certain physical techniques and related integrity constraints within the subject area of Skill Science.

  13. Discovering New Light States at Neutrino Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Essig, Rouven; /SLAC; Harnik, Roni; /Fermilab; Kaplan, Jared; /SLAC; Toro, Natalia; /Stanford U., Phys. Dept.

    2011-08-11

    Experiments designed to measure neutrino oscillations also provide major opportunities for discovering very weakly coupled states. In order to produce neutrinos, experiments such as LSND collide thousands of Coulombs of protons into fixed targets, while MINOS and MiniBooNE also focus and then dump beams of muons. The neutrino detectors beyond these beam dumps are therefore an excellent arena in which to look for long-lived pseudoscalars or for vector bosons that kinetically mix with the photon. We show that these experiments have significant sensitivity beyond previous beam dumps, and are able to partially close the gap between laboratory experiments and supernovae constraints on pseudoscalars. Future upgrades to the NuMI beamline and Project X will lead to even greater opportunities for discovery. We also discuss thin target experiments with muon beams, such as those available in COMPASS, and show that they constitute a powerful probe for leptophilic PNGBs.

  14. Discovering the Library with Google Earth

    Directory of Open Access Journals (Sweden)

    Michaela Brenner

    2008-06-01

    Full Text Available Libraries need to provide attractive and exciting discovery tools to draw patrons to the valuable resources in their catalogs. The authors conducted a pilot project to explore the free version of Google Earth as such a discover tool for Portland State Library’s digital collection of urban planning documents. They created eye-catching placemarks with links to parts of this collection, as well as to other pertinent materials like books, images, and historical background information. The detailed how-to-do part of this article is preceded by a discussion about discovery of library materials and followed by possible applications of this Google Earth project.

  15. Discovering the Unexpected in Astronomical Survey Data

    CERN Document Server

    Norris, Ray P

    2016-01-01

    Most major discoveries in astronomy are unplanned, and result from surveying the Universe in a new way, rather than by testing a hypothesis or conducting an investigation with planned outcomes. For example, of the 10 greatest discoveries made by the Hubble Space Telescope, only one was listed in its key science goals. So a telescope that merely achieves its stated science goals is not achieving its potential scientific productivity. Several next-generation astronomical survey telescopes are currently being designed and constructed that will significantly expand the volume of observational parameter space, and should in principle discover unexpected new phenomena and new types of object. However, the complexity of the telescopes and the large data volumes mean that these discoveries are unlikely to be found by chance. Therefore, it is necessary to plan explicitly for these unexpected discoveries in the design and construction of the telescope. Two types of discovery are recognised: unexpected objects, and unex...

  16. Discovering Multidimensional Structure in Relational Data

    DEFF Research Database (Denmark)

    Jensen, Mikael Rune; Holmgren, Thomas; Pedersen, Torben Bach

    2004-01-01

    On-Line Analytical Processing (OLAP) systems based on multidimensional databases are essential elements of decision support. However, most existing data is stored in “ordinary” relational OLTP databases, i.e., data has to be (re-) modeled as multidimensional cubes before the advantages of OLAP...... tools are available. In this paper we present an approach for the automatic construction of multidimensional OLAP database schemas from existing relational OLTP databases, enabling easy OLAP design and analysis for most existing data sources. This is achieved through a set of practical and effective...... algorithms for discovering multidimensional schemas from relational databases. The algorithms take a wide range of available metadata into account in the discovery process, including functional and inclusion dependencies, and key and cardinality information....

  17. 76 FR 4393 - Discover Financial Services Negotiated Service Agreement

    Science.gov (United States)

    2011-01-25

    ... Discover Financial Services Negotiated Service Agreement AGENCY: Postal Regulatory Commission. ACTION... Financial Services negotiated service agreement to the market dominant product list. This notice addresses... 3020, et seq., to add a Discover Financial Services (DFS) negotiated service agreement to the...

  18. Digging Deeper: Looking Beyond Behavior to Discover Meaning

    Medline Plus

    Full Text Available ... Digging Deeper: Looking Beyond Behavior to Discover Meaning A Unit of Four Online Lessons Digging Deeper: Looking Beyond Behavior to Discover Meaning is a unit of four lessons that explore and apply ...

  19. 33 CFR 179.05 - Manufacturer discovered defects.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manufacturer discovered defects... (CONTINUED) BOATING SAFETY DEFECT NOTIFICATION § 179.05 Manufacturer discovered defects. Each manufacturer... under 46 U.S.C. 4310(b), shall furnish that notice within 30 days after the manufacturer discovers...

  20. Discovering the Ancient Maya from Space

    Science.gov (United States)

    Sever, T. L.

    2008-01-01

    The Pet6n region of northern Guatemala contains some of the most significant Mayan archeological sites in Latin America. It was in this region that the Maya civilization began, flourished, and abruptly disappeared. Remote sensing technology is helping to locate and map ancient Maya sites that are threatened today by accelerating deforestation and looting. Thematic Mapper, IKONOS, and QuickBird satellite, and airborne STAR-3i and AIRSAR radar data, combined with Global Positioning System (GPS) technology, are successfully detecting ancient Maya features such as sites, roadways, canals, and water reservoirs. Satellite imagery is also being used to map the bajos, which are seasonally flooded swamps that cover over 40% of the land surface. Through the use of various airborne and satellite sensor systems we have been able to detect and map ancient causeways, temples, reservoirs, and land forms, and locate these features on the ground through GPS technology. Recently, we have discovered that there is a strong relationship between a tropical forest vegetation signature in satellite imagery and the location of archeological sites. We believe that the use of limestone and lime plasters in ancient Maya construction affects the moisture, nutrition, and plant species of the surface vegetation. We have mapped these vegetation signatures in the imagery and verified through field survey that they are indicative of archeological sites. Through the use of remote sensing and GIS technology it is possible to identify unrecorded archeological features in a dense tropical forest environment and monitor these cultural features for their protection.

  1. Intergalactic HII Regions Discovered in SINGG

    CERN Document Server

    Ryan-Weber, E V; Freeman, K C; Putman, M E; Webster, R L; team., the SINGG

    2003-01-01

    A number of very small isolated HII regions have been discovered at projected distances up to 30 kpc from their nearest galaxy. These HII regions appear as tiny emission line objects in narrow band images obtained by the NOAO Survey for Ionization in Neutral Gas Galaxies (SINGG). We present spectroscopic confirmation of four isolated HII regions in two systems, both systems have tidal HI features. The results are consistent with stars forming in interactive debris due to cloud-cloud collisions. The H-alpha luminosities of the isolated HII regions are equivalent to the ionizing flux of only a few O stars each. They are most likely ionized by stars formed in situ, and represent atypical star formation in the low density environment of the outer parts of galaxies. A small but finite intergalactic star formation rate will enrich and ionize the surrounding medium. In one system, NGC 1533, we calculate a star formation rate of 1.5e-3 msun/yr, resulting in a metal enrichment of ~1e-3 solar for the continuous formati...

  2. Discover Space: an IYA program for libraries

    Science.gov (United States)

    Dusenbery, P.

    2009-12-01

    Across the country, there is a growing concern regarding the number of students entering science and technology careers. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. This is particularly true when family interactions are factored in. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The nation’s more than 17,000 public libraries attract diverse audiences in almost every community. Science exhibits in libraries could potentially reach many adults and upper elementary and middle school students with STEM content. The Space Science Institute (SSI) is partnering with the American Library Association (ALA) to develop a pilot exhibit called Discover Space. The exhibit includes two areas: Space Storms and Star Quest and is currently on tour in Colorado. It is a featured IYA outreach project from SSI. This presentation will focus on the results of a national survey of libraries that SSI and ALA conducted in 2008 about interest in STEM exhibits as well as the development process that was used to design and fabricate the exhibit. Preliminary evaluation results will also be shared. The presentation will conclude with an examination of how this program could benefit underserved communities around the country.

  3. Translating Others, Discovering Himself: Beckett as Translator

    Directory of Open Access Journals (Sweden)

    Darren Gribben

    2011-08-01

    Full Text Available This paper examines the work of Samuel Beckett in the light of his early work as a translator of the works of other writers.  In his translations for Negro: An Anthology (1934, the Anthology of Mexican Poetry (1958, or commissioned translations for journals such as “This Quarter”, early pre-figurings of Beckett’s own thematic and linguistic concerns abound.  Rarely viewed as more than acts of raising money for himself, Beckett’s acts of translation, examined chronologically, demonstrate a writer discovering his craft, and developing his unique voice, unencumbered by the expectations of originality.  This essay posits that Beckett’s works, with their distinctive voice and characterisation, owe much to the global perspective he gained through translating across cultural, continental divides, as well as experimenting with form, which became a staple of Beckett’s own work.  Without formal training or theoretical grounding in translation, Beckett utilises the act of translation as a means of finding himself, revisiting it as a means of shaping his own unique literary voice.

  4. Imminent science what remains to be discovered

    CERN Document Server

    Bignami, Giovanni F

    2014-01-01

    This is not science fiction. It’s a voyage on the arrow of time to the coming fifty years. The legendary palindromic character Mr. Qfwfq from Italo Calvino’s collection of short stories, The Cosmicomics, will go with us – he who knows all the answers but will give out no hints. He will help us to discover the innovations that will have changed our lives by 2062, when, riding astride Halley’s Comet, our omniscient extraterrestrial will return to visit us.In this book, we shall learn how astronomers will devote themselves to the study of the mysterious force of dark energy, which makes up some three-quarters of the Universe. We shall also delve deeply into the study of our Earth, to exploit the immense thermal energy that lies beneath our feet. We shall solve another enigma in today’s science: the origin of life. We shall come to understand how to develop direct contacts between our brains and the rest of the world. We shall learn about the future of genetics, the reason for the longevity of Methusela...

  5. Astronomers Discover Fastest-Spinning Pulsar

    Science.gov (United States)

    2006-01-01

    Astronomers using the National Science Foundation's Robert C. Byrd Green Bank Telescope have discovered the fastest-spinning neutron star ever found, a 20-mile-diameter superdense pulsar whirling faster than the blades of a kitchen blender. Their work yields important new information about the nature of one of the most exotic forms of matter known in the Universe. Pulsar Graphic Pulsars Are Spinning Neutron Stars CREDIT: Bill Saxton, NRAO/AUI/NSF (Click on image for larger version) "We believe that the matter in neutron stars is denser than an atomic nucleus, but it is unclear by how much. Our observations of such a rapidly rotating star set a hard upper limit on its size, and hence on how dense the star can be.," said Jason Hessels, a graduate student at McGill University in Montreal. Hessels and his colleagues presented their findings to the American Astronomical Society's meeting in Washington, DC. Pulsars are spinning neutron stars that sling "lighthouse beams" of radio waves or light around as they spin. A neutron star is what is left after a massive star explodes at the end of its "normal" life. With no nuclear fuel left to produce energy to offset the stellar remnant's weight, its material is compressed to extreme densities. The pressure squeezes together most of its protons and electrons to form neutrons; hence, the name "neutron star." "Neutron stars are incredible laboratories for learning about the physics of the fundamental particles of nature, and this pulsar has given us an important new limit," explained Scott Ransom, an astronomer at the National Radio Astronomy Observatory and one of Hessels' collaborators on this work. The scientists discovered the pulsar, named PSR J1748-2446ad, in a globular cluster of stars called Terzan 5, located some 28,000 light-years from Earth in the constellation Sagittarius. The newly-discovered pulsar is spinning 716 times per second, or at 716 Hertz (Hz), readily beating the previous record of 642 Hz from a pulsar

  6. ROSAT Discovers Unique, Distant Cluster of Galaxies

    Science.gov (United States)

    1995-06-01

    Brightest X-ray Cluster Acts as Strong Gravitational Lens Based on exciting new data obtained with the ROSAT X-ray satellite and a ground-based telescope at the ESO La Silla Observatory, a team of European astronomers [2] has just discovered a very distant cluster of galaxies with unique properties. It emits the strongest X-ray emission of any cluster ever observed by ROSAT and is accompanied by two extraordinarily luminous arcs that represent the gravitationally deflected images of even more distant objects. The combination of these unusual characteristics makes this cluster, now known as RXJ1347.5-1145, a most interesting object for further cosmological studies. DISCOVERY AND FOLLOW-UP OBSERVATIONS This strange cluster of galaxies was discovered during the All Sky Survey with the ROSAT X-ray satellite as a moderately intense X-ray source in the constellation of Virgo. It could not be identified with any already known object and additional ground-based observations were therefore soon after performed with the Max-Planck-Society/ESO 2.2-metre telescope at the La Silla observatory in Chile. These observations took place within a large--scale redshift survey of X-ray clusters of galaxies detected by the ROSAT All Sky Survey, a so-called ``ESO Key Programme'' led by astronomers from the Max-Planck-Institut fur Extraterrestrische Physik and the Osservatorio Astronomico di Brera. The main aim of this programme is to identify cluster X-ray sources, to determine the distance to the X-ray emitting clusters and to investigate their overall properties. These observations permitted to measure the redshift of the RXJ1347.5-1145 cluster as z = 0.45, i.e. it moves away from us with a velocity (about 106,000 km/sec) equal to about one-third of the velocity of light. This is an effect of the general expansion of the universe and it allows to determine the distance as about 5,000 million light-years (assuming a Hubble constant of 75 km/sec/Mpc). In other words, we see these

  7. THE MOST LUMINOUS GALAXIES DISCOVERED BY WISE

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Chao-Wei; Eisenhardt, Peter R. M.; Stern, Daniel; Moustakas, Leonidas A. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Dr., Pasadena, CA 91109 (United States); Wu, Jingwen; Wright, Edward L. [Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095-1547 (United States); Assef, Roberto J. [Núcleo de Astronomía de la Facultad deIngeniería, Universidad Diego Portales, Av. Ejército Libertador 441, Santiago (Chile); Blain, Andrew W. [Department of Physics and Astronomy, University of Leicester, 1 University Road, Leicester, LE1 7RH (United Kingdom); Bridge, Carrie R.; Sayers, Jack [Division of Physics, Math, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Benford, Dominic J.; Leisawitz, David T. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Cutri, Roc M.; Masci, Frank J.; Yan, Lin [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Griffith, Roger L. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Jarrett, Thomas H. [Astronomy Department, University of Cape Town, Private Bag X3, Rondebosch 7701 (South Africa); Lonsdale, Carol J. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Petty, Sara M. [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Stanford, S. Adam, E-mail: Chao-Wei.Tsai@jpl.nasa.gov [Department of Physics, University of California Davis, One Shields Avenue, Davis, CA 95616 (United States); and others

    2015-06-01

    We present 20 Wide-field Infrared Survey Explorer (WISE)-selected galaxies with bolometric luminosities L{sub bol} > 10{sup 14} L{sub ☉}, including five with infrared luminosities L{sub IR} ≡ L{sub (rest} {sub 8–1000} {sub μm)} > 10{sup 14} L{sub ☉}. These “extremely luminous infrared galaxies,” or ELIRGs, were discovered using the “W1W2-dropout” selection criteria which requires marginal or non-detections at 3.4 and 4.6 μm (W1 and W2, respectively) but strong detections at 12 and 22 μm in the WISE survey. Their spectral energy distributions are dominated by emission at rest-frame 4–10 μm, suggesting that hot dust with T{sub d} ∼ 450 K is responsible for the high luminosities. These galaxies are likely powered by highly obscured active galactic nuclei (AGNs), and there is no evidence suggesting these systems are beamed or lensed. We compare this WISE-selected sample with 116 optically selected quasars that reach the same L{sub bol} level, corresponding to the most luminous unobscured quasars in the literature. We find that the rest-frame 5.8 and 7.8 μm luminosities of the WISE-selected ELIRGs can be 30%–80% higher than that of the unobscured quasars. The existence of AGNs with L{sub bol} > 10{sup 14} L{sub ☉} at z > 3 suggests that these supermassive black holes are born with large mass, or have very rapid mass assembly. For black hole seed masses ∼10{sup 3} M{sub ☉}, either sustained super-Eddington accretion is needed, or the radiative efficiency must be <15%, implying a black hole with slow spin, possibly due to chaotic accretion.

  8. Discovering biological progression underlying microarray samples.

    Directory of Open Access Journals (Sweden)

    Peng Qiu

    2011-04-01

    Full Text Available In biological systems that undergo processes such as differentiation, a clear concept of progression exists. We present a novel computational approach, called Sample Progression Discovery (SPD, to discover patterns of biological progression underlying microarray gene expression data. SPD assumes that individual samples of a microarray dataset are related by an unknown biological process (i.e., differentiation, development, cell cycle, disease progression, and that each sample represents one unknown point along the progression of that process. SPD aims to organize the samples in a manner that reveals the underlying progression and to simultaneously identify subsets of genes that are responsible for that progression. We demonstrate the performance of SPD on a variety of microarray datasets that were generated by sampling a biological process at different points along its progression, without providing SPD any information of the underlying process. When applied to a cell cycle time series microarray dataset, SPD was not provided any prior knowledge of samples' time order or of which genes are cell-cycle regulated, yet SPD recovered the correct time order and identified many genes that have been associated with the cell cycle. When applied to B-cell differentiation data, SPD recovered the correct order of stages of normal B-cell differentiation and the linkage between preB-ALL tumor cells with their cell origin preB. When applied to mouse embryonic stem cell differentiation data, SPD uncovered a landscape of ESC differentiation into various lineages and genes that represent both generic and lineage specific processes. When applied to a prostate cancer microarray dataset, SPD identified gene modules that reflect a progression consistent with disease stages. SPD may be best viewed as a novel tool for synthesizing biological hypotheses because it provides a likely biological progression underlying a microarray dataset and, perhaps more importantly, the

  9. VLA Discovers Giant Rings Around Galaxy Cluster

    Science.gov (United States)

    2006-11-01

    Astronomers using the National Science Foundation's Very Large Array (VLA) radio telescope have discovered giant, ring-like structures around a cluster of galaxies. The discovery provides tantalizing new information about how such galaxy clusters are assembled, about magnetic fields in the vast spaces between galaxy clusters, and possibly about the origin of cosmic rays. Radio-Optical Image of Cluster Galaxy Cluster Abell 3376 (Radio/Optical) CREDIT: Joydeep Bagchi, IUCAA, NRAO/AUI/NSF Above, a combined radio/optical image shows the galaxy cluster Abell 3376 in visible light (blue) and radio (red) images. The giant radio arcs surrounding the cluster were discovered using the Very Large Array. The visible-light image is from the Digitized Sky survey. Below, an X-ray image of Abell 3376 made using the European Space Agency's XMM-Newton telescope shows a spectacular, bullet-shaped region of X-rays coming from gas heated to 60 million degrees Kelvin. The bullet shape results from the supersonic collision of a smaller smaller galaxy subcluster with the main body of the larger cluster. Click on images for larger version. X-Ray Image of Cluster Galaxy Cluster Abell 3376 (X-Ray) CREDIT: Joydeep Bagchi, IUCAA, ESA "These giant, radio-emitting rings probably are the result of shock waves caused by violent collisions of smaller groups of galaxies within the cluster," said Joydeep Bagchi, of the Inter-University Centre for Astronomy and Astrophysics in Pune, India, who led an international research team. The scientists reported their findings in the November 3 edition of the journal Science. The newly-discovered ring segments, some 6 million light-years across, surround a galaxy cluster called Abell 3376, more than 600 million light-years from Earth. They were revealed because fast-moving electrons emitted radio waves as they spiraled around magnetic field lines in intergalactic space. "Even from this large distance, the feeble radio waves were easily picked up by the VLA

  10. Angle resolved photoemission in semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Petroff, Y.

    1983-02-01

    Bases of angular resolved photoemission: determination of the electronic band structure of solids (bulk), measurements of life-time and mean free path, determination of surfaces states (valence and core) and their relationship with surface reconstruction are described.

  11. RESOLVE and ECO: Survey Design

    Science.gov (United States)

    Kannappan, Sheila; Moffett, Amanda J.; Norris, Mark A.; Eckert, Kathleen D.; Stark, David; Berlind, Andreas A.; Snyder, Elaine M.; Norman, Dara J.; Hoversten, Erik A.; RESOLVE Team

    2016-01-01

    The REsolved Spectroscopy Of a Local VolumE (RESOLVE) survey is a volume-limited census of stellar, gas, and dynamical mass as well as star formation and galaxy interactions within >50,000 cubic Mpc of the nearby cosmic web, reaching down to dwarf galaxies of baryonic mass ~10^9 Msun and spanning multiple large-scale filaments, walls, and voids. RESOLVE is surrounded by the ~10x larger Environmental COntext (ECO) catalog, with matched custom photometry and environment metrics enabling analysis of cosmic variance with greater statistical power. For the ~1500 galaxies in its two equatorial footprints, RESOLVE goes beyond ECO in providing (i) deep 21cm data with adaptive sensitivity ensuring HI mass detections or upper limits designed to complement other radio and optical surveys in providing diverse, contiguous, and uniform local/global environment data as well as unusually high completeness extending into the gas-dominated dwarf galaxy regime. RESOLVE also offers superb reprocessed photometry including full, deep NUV coverage and synergy with other equatorial surveys as well as unique northern and southern facilities such as Arecibo, the GBT, and ALMA. The RESOLVE and ECO surveys have been supported by funding from NSF grants AST-0955368 and OCI-1156614.

  12. The Impact of Discovering Life beyond Earth

    Science.gov (United States)

    Dick, Steven J.

    2015-10-01

    Introduction: astrobiology and society Steven J. Dick; Part I. Motivations and Approaches. How Do We Frame the Problems of Discovery and Impact?: Introduction; 1. Current approaches to finding life beyond earth, and what happens if we do Seth Shostak; 2. The philosophy of astrobiology: the Copernican and Darwinian presuppositions Iris Fry; 3. History, discovery, analogy: three approaches to the impact of discovering life beyond earth Steven J. Dick; 4. Silent impact: why the discovery of extraterrestrial life should be silent Clément Vidal; Part II. Transcending Anthropocentrism. How Do We Move beyond our Own Preconceptions of Life, Intelligence and Culture?: Introduction; 5. The landscape of life Dirk Schulze-Makuch; 6. The landscape of intelligence Lori Marino; 7. Universal biology: assessing universality from a single example Carlos Mariscal; 8. Equating culture, civilization, and moral development in imagining extraterrestrial intelligence: anthropocentric assumptions? John Traphagan; 9. Communicating with the other: infinity, geometry, and universal math and science Douglas Vakoch; Part III. Philosophical, Theological, and Moral Impact. How Do We Comprehend the Cultural Challenges Raised by Discovery?: Introduction; 10. Life, intelligence and the pursuit of value in cosmic evolution Mark Lupisella; 11. 'Klaatu barada nikto' - or, do they really think like us? Michael Ruse; 12. Alien minds Susan Schneider; 13. The moral subject of astrobiology: guideposts for exploring our ethical and political responsibilities towards extraterrestrial life Elspeth Wilson and Carol Cleland; 14. Astrobiology and theology Robin Lovin; 15. Would you baptize an extraterrestrial? Guy Consolmagno, SJ; Part IV. Practical Considerations: How Should Society Prepare for Discovery - and Non-Discovery?: Introduction; 16. Is there anything new about astrobiology and society? Jane Maienschein; 17. Evaluating preparedness for the discovery of extraterrestrial life: considering potential

  13. Discovering Extrasolar Planets with Microlensing Surveys

    Science.gov (United States)

    Wambsganss, J.

    2016-06-01

    An astronomical survey is commonly understood as a mapping of a large region of the sky, either photometrically (possibly in various filters/wavelength ranges) or spectroscopically. Often, catalogs of objects are produced/provided as the main product or a by-product. However, with the advent of large CCD cameras and dedicated telescopes with wide-field imaging capabilities, it became possible in the early 1990s, to map the same region of the sky over and over again. In principle, such data sets could be combined to get very deep stacked images of the regions of interest. However, I will report on a completely different use of such repeated maps: Exploring the time domain for particular kinds of stellar variability, namely microlens-induced magnifications in search of exoplanets. Such a time-domain microlensing survey was originally proposed by Bohdan Paczynski in 1986 in order to search for dark matter objects in the Galactic halo. Only a few years later three teams started this endeavour. I will report on the history and current state of gravitational microlensing surveys. By now, routinely 100 million stars in the Galactic Bulge are monitored a few times per week by so-called survey teams. All stars with constant apparent brightness and those following known variability patterns are filtered out in order to detect the roughly 2000 microlensing events per year which are produced by stellar lenses. These microlensing events are identified "online" while still in their early phases and then monitored with much higher cadence by so-called follow-up teams. The most interesting of such events are those produced by a star-plus-planet lens. By now of order 30 exoplanets have been discovered by these combined microlensing surveys. Microlensing searches for extrasolar planets are complementary to other exoplanet search techniques. There are two particular advantages: The microlensing method is sensitive down to Earth-mass planets even with ground-based telecopes, and it

  14. The Impact of Discovering Life beyond Earth

    Science.gov (United States)

    Dick, Steven J.

    2016-01-01

    Introduction: astrobiology and society Steven J. Dick; Part I. Motivations and Approaches. How Do We Frame the Problems of Discovery and Impact?: Introduction; 1. Current approaches to finding life beyond earth, and what happens if we do Seth Shostak; 2. The philosophy of astrobiology: the Copernican and Darwinian presuppositions Iris Fry; 3. History, discovery, analogy: three approaches to the impact of discovering life beyond earth Steven J. Dick; 4. Silent impact: why the discovery of extraterrestrial life should be silent Clément Vidal; Part II. Transcending Anthropocentrism. How Do We Move beyond our Own Preconceptions of Life, Intelligence and Culture?: Introduction; 5. The landscape of life Dirk Schulze-Makuch; 6. The landscape of intelligence Lori Marino; 7. Universal biology: assessing universality from a single example Carlos Mariscal; 8. Equating culture, civilization, and moral development in imagining extraterrestrial intelligence: anthropocentric assumptions? John Traphagan; 9. Communicating with the other: infinity, geometry, and universal math and science Douglas Vakoch; Part III. Philosophical, Theological, and Moral Impact. How Do We Comprehend the Cultural Challenges Raised by Discovery?: Introduction; 10. Life, intelligence and the pursuit of value in cosmic evolution Mark Lupisella; 11. 'Klaatu barada nikto' - or, do they really think like us? Michael Ruse; 12. Alien minds Susan Schneider; 13. The moral subject of astrobiology: guideposts for exploring our ethical and political responsibilities towards extraterrestrial life Elspeth Wilson and Carol Cleland; 14. Astrobiology and theology Robin Lovin; 15. Would you baptize an extraterrestrial? Guy Consolmagno, SJ; Part IV. Practical Considerations: How Should Society Prepare for Discovery - and Non-Discovery?: Introduction; 16. Is there anything new about astrobiology and society? Jane Maienschein; 17. Evaluating preparedness for the discovery of extraterrestrial life: considering potential

  15. Time resolved spectroscopy of GRB 030501 using INTEGRAL

    DEFF Research Database (Denmark)

    Beckmann, V.; Borkowski, J.; Courvoisier, T.J.L.;

    2003-01-01

    The gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst...... Alert System in the ISGRI field of view. Although the burst was fairly weak (fluence F20-200 keV similar or equal to 3.5x10(-6) erg cm(-2)) it was possible to perform time resolved spectroscopy with a resolution of a few seconds. The GRB shows a spectrum in the 20-400 keV range which is consistent...

  16. PSLQ: An Algorithm to Discover Integer Relations

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, J. M.

    2009-04-03

    Let x = (x{sub 1}, x{sub 2} {hor_ellipsis}, x{sub n}) be a vector of real or complex numbers. x is said to possess an integer relation if there exist integers a{sub i}, not all zero, such that a{sub 1}x{sub 1} + a{sub 2}x{sub 2} + {hor_ellipsis} + a{sub n}x{sub n} = 0. By an integer relation algorithm, we mean a practical computational scheme that can recover the vector of integers ai, if it exists, or can produce bounds within which no integer relation exists. As we will see in the examples below, an integer relation algorithm can be used to recognize a computed constant in terms of a formula involving known constants, or to discover an underlying relation between quantities that can be computed to high precision. At the present time, the most effective algorithm for integer relation detection is the 'PSLQ' algorithm of mathematician-sculptor Helaman Ferguson [10, 4]. Some efficient 'multi-level' implementations of PSLQ, as well as a variant of PSLQ that is well-suited for highly parallel computer systems, are given in [4]. PSLQ constructs a sequence of integer-valued matrices B{sub n} that reduces the vector y = xB{sub n}, until either the relation is found (as one of the columns of B{sub n}), or else precision is exhausted. At the same time, PSLQ generates a steadily growing bound on the size of any possible relation. When a relation is found, the size of smallest entry of the vector y abruptly drops to roughly 'epsilon' (i.e. 10{sup -p}, where p is the number of digits of precision). The size of this drop can be viewed as a 'confidence level' that the relation is real and not merely a numerical artifact - a drop of 20 or more orders of magnitude almost always indicates a real relation. Very high precision arithmetic must be used in PSLQ. If one wishes to recover a relation of length n, with coefficients of maximum size d digits, then the input vector x must be specified to at least nd digits, and one must employ nd

  17. Resolving Boosted Jets with XCone

    CERN Document Server

    Thaler, Jesse

    2015-01-01

    We show how the recently proposed XCone jet algorithm smoothly interpolates between resolved and boosted kinematics. When using standard jet algorithms to reconstruct the decays of hadronic resonances like top quarks and Higgs bosons, one typically needs separate analysis strategies to handle the resolved regime of well-separated jets and the boosted regime of fat jets with substructure. XCone, by contrast, is an exclusive cone jet algorithm that always returns a fixed number of jets, so jet regions remain resolved even when (sub)jets are overlapping in the boosted regime. In this paper, we perform three LHC case studies---dijet resonances, Higgs decays to bottom quarks, and all-hadronic top pairs---that demonstrate the physics applications of XCone over a wide kinematic range.

  18. Discovering motifs in ranked lists of DNA sequences.

    Directory of Open Access Journals (Sweden)

    Eran Eden

    2007-03-01

    Full Text Available Computational methods for discovery of sequence elements that are enriched in a target set compared with a background set are fundamental in molecular biology research. One example is the discovery of transcription factor binding motifs that are inferred from ChIP-chip (chromatin immuno-precipitation on a microarray measurements. Several major challenges in sequence motif discovery still require consideration: (i the need for a principled approach to partitioning the data into target and background sets; (ii the lack of rigorous models and of an exact p-value for measuring motif enrichment; (iii the need for an appropriate framework for accounting for motif multiplicity; (iv the tendency, in many of the existing methods, to report presumably significant motifs even when applied to randomly generated data. In this paper we present a statistical framework for discovering enriched sequence elements in ranked lists that resolves these four issues. We demonstrate the implementation of this framework in a software application, termed DRIM (discovery of rank imbalanced motifs, which identifies sequence motifs in lists of ranked DNA sequences. We applied DRIM to ChIP-chip and CpG methylation data and obtained the following results. (i Identification of 50 novel putative transcription factor (TF binding sites in yeast ChIP-chip data. The biological function of some of them was further investigated to gain new insights on transcription regulation networks in yeast. For example, our discoveries enable the elucidation of the network of the TF ARO80. Another finding concerns a systematic TF binding enhancement to sequences containing CA repeats. (ii Discovery of novel motifs in human cancer CpG methylation data. Remarkably, most of these motifs are similar to DNA sequence elements bound by the Polycomb complex that promotes histone methylation. Our findings thus support a model in which histone methylation and CpG methylation are mechanistically linked

  19. Youngest Stellar Explosion in Our Galaxy Discovered

    Science.gov (United States)

    2008-05-01

    Astronomers have found the remains of the youngest supernova, or exploded star, in our Galaxy. The supernova remnant, hidden behind a thick veil of gas and dust, was revealed by the National Science Foundation's Very Large Array (VLA) and NASA's Chandra X-Ray Observatory, which could see through the murk. The object is the first example of a "missing population" of young supernova remnants. 1985 and 2008 VLA Images Move cursor over image to blink. VLA Images of G1.9+0.3 in 1985 and 2008: Circle for size comparison. CREDIT: Green, et al., NRAO/AUI/NSF From observing supernovae in other galaxies, astronomers have estimated that about three such stellar explosions should occur in our Milky Way every century. However, the most recent one known until now occurred around 1680, creating the remnant called Cassiopeia A. The newly-discovered object is the remnant of an explosion only about 140 years ago. "If the supernova rate estimates are correct, there should be the remnants of about 10 supernova explosions in the Milky Way that are younger than Cassiopeia A," said David Green of the University of Cambridge in the UK, who led the VLA study. "It's great to finally track one of them down." Supernova explosions, which mark the violent death of a star, release tremendous amounts of energy and spew heavy elements such as calcium and iron into interstellar space. They thus seed the clouds of gas and dust from which new stars and planets are formed and, through their blast shocks, can even trigger such formation. The lack of evidence for young supernova remnants in the Milky Way had caused astronomers to wonder if our Galaxy, which appears otherwise normal, differed in some unknown way from others. Alternatively, scientists thought that the "missing" Milky Way supernovae perhaps indicated that their understanding of the relationship between supernovae and other galactic processes was in error. The astronomers made their discovery by measuring the expansion of the debris from

  20. Resolving Ethical Issues at School

    Science.gov (United States)

    Benninga, Jacques S.

    2013-01-01

    Although ethical dilemmas are a constant in teachers' lives, the profession has offered little in the way of training to help teachers address such issues. This paper presents a framework, based on developmental theory, for resolving professional ethical dilemmas. The Four-Component Model of Moral Maturity, when used in conjunction with a…

  1. TIME-RESOLVED VIBRATIONAL SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Andrei Tokmakoff, MIT (Conference Chair); Paul Champion, Northeastern University; Edwin J. Heilweil, NIST; Keith A. Nelson, MIT; Larry Ziegler, Boston University

    2009-05-14

    This document contains the Proceedings from the 14th International Conference on Time-Resolved Vibrational Spectroscopy, which was held in Meredith, NH from May 9-14, 2009. The study of molecular dynamics in chemical reaction and biological processes using time-resolved spectroscopy plays an important role in our understanding of energy conversion, storage, and utilization problems. Fundamental studies of chemical reactivity, molecular rearrangements, and charge transport are broadly supported by the DOE’s Office of Science because of their role in the development of alternative energy sources, the understanding of biological energy conversion processes, the efficient utilization of existing energy resources, and the mitigation of reactive intermediates in radiation chemistry. In addition, time-resolved spectroscopy is central to all five of DOE’s grand challenges for fundamental energy science. The Time-Resolved Vibrational Spectroscopy conference is organized biennially to bring the leaders in this field from around the globe together with young scientists to discuss the most recent scientific and technological advances. The latest technology in ultrafast infrared, Raman, and terahertz spectroscopy and the scientific advances that these methods enable were covered. Particular emphasis was placed on new experimental methods used to probe molecular dynamics in liquids, solids, interfaces, nanostructured materials, and biomolecules.

  2. Time-resolved vibrational spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tokmakoff, Andrei [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Champion, Paul [Northeastern Univ., Boston, MA (United States); Heilweil, Edwin J. [National Inst. of Standards and Technology (NIST), Boulder, CO (United States); Nelson, Keith A. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Ziegler, Larry [Boston Univ., MA (United States)

    2009-05-14

    This document contains the Proceedings from the 14th International Conference on Time-Resolved Vibrational Spectroscopy, which was held in Meredith, NH from May 9-14, 2009. The study of molecular dynamics in chemical reaction and biological processes using time-resolved spectroscopy plays an important role in our understanding of energy conversion, storage, and utilization problems. Fundamental studies of chemical reactivity, molecular rearrangements, and charge transport are broadly supported by the DOE's Office of Science because of their role in the development of alternative energy sources, the understanding of biological energy conversion processes, the efficient utilization of existing energy resources, and the mitigation of reactive intermediates in radiation chemistry. In addition, time-resolved spectroscopy is central to all fiveof DOE's grand challenges for fundamental energy science. The Time-Resolved Vibrational Spectroscopy conference is organized biennially to bring the leaders in this field from around the globe together with young scientists to discuss the most recent scientific and technological advances. The latest technology in ultrafast infrared, Raman, and terahertz spectroscopy and the scientific advances that these methods enable were covered. Particular emphasis was placed on new experimental methods used to probe molecular dynamics in liquids, solids, interfaces, nanostructured materials, and biomolecules.

  3. Time-resolved molecular imaging

    Science.gov (United States)

    Xu, Junliang; Blaga, Cosmin I.; Agostini, Pierre; DiMauro, Louis F.

    2016-06-01

    Time-resolved molecular imaging is a frontier of ultrafast optical science and physical chemistry. In this article, we review present and future key spectroscopic and microscopic techniques for ultrafast imaging of molecular dynamics and show their differences and connections. The advent of femtosecond lasers and free electron x-ray lasers bring us closer to this goal, which eventually will extend our knowledge about molecular dynamics to the attosecond time domain.

  4. Resolved observations of transition disks

    CERN Document Server

    Casassus, Simon

    2016-01-01

    Resolved observations are bringing new constraints on the origin of radial gaps in protoplanetary disks. The kinematics, sampled in detail in one case-study, are indicative of non-Keplerian flows, corresponding to warped structures and accretion which may both play a role in the development of cavities. Disk asymmetries seen in the radio continuum are being interpreted in the context of dust segregation via aerodynamic trapping. We summarise recent observational progress, and also describe prospects for improvements in the near term.

  5. Weak Total Resolvability In Graphs

    Directory of Open Access Journals (Sweden)

    Casel Katrin

    2016-02-01

    Full Text Available A vertex v ∈ V (G is said to distinguish two vertices x, y ∈ V (G of a graph G if the distance from v to x is di erent from the distance from v to y. A set W ⊆ V (G is a total resolving set for a graph G if for every pair of vertices x, y ∈ V (G, there exists some vertex w ∈ W − {x, y} which distinguishes x and y, while W is a weak total resolving set if for every x ∈ V (G−W and y ∈ W, there exists some w ∈ W −{y} which distinguishes x and y. A weak total resolving set of minimum cardinality is called a weak total metric basis of G and its cardinality the weak total metric dimension of G. Our main contributions are the following ones: (a Graphs with small and large weak total metric bases are characterised. (b We explore the (tight relation to independent 2-domination. (c We introduce a new graph parameter, called weak total adjacency dimension and present results that are analogous to those presented for weak total dimension. (d For trees, we derive a characterisation of the weak total (adjacency metric dimension. Also, exact figures for our parameters are presented for (generalised fans and wheels. (e We show that for Cartesian product graphs, the weak total (adjacency metric dimension is usually pretty small. (f The weak total (adjacency dimension is studied for lexicographic products of graphs.

  6. Lifetime Resolved Fluorescence Fluctuation Spectroscopy

    Science.gov (United States)

    Guo, Peng; Berland, Keith

    2009-11-01

    Fluorescence correlation spectroscopy (FCS) has been widely used investigate molecular dynamics and interactions in biological systems. FCS typically resolves the component species of a sample either through differences in diffusion coefficient or molecular brightness. Diffusion based assays currently have a major limitation which requires that the diffusion coefficients of component species in a sample must be substantially different in order to be resolved. This criterion is not met in many important cases, such as when molecules of similar molecular weight bind to each other. This limitation can be overcome, and resolution of FCS measurements enhanced, by combining FCS measurements with measurements of fluorescence lifetimes. By using of global analysis on simultaneously acquired FCS and lifetime data we show that we can dramatically enhance resolution in FCS measurements, and accurately resolve the concentration and diffusion coefficients of multiple sample components even when their diffusion coefficients are identical provided there is a difference in the lifetime of the component species. We show examples of this technique using both simulations and experiments. It is expected that this method will be of significance for binding assays studying molecular interactions.

  7. Distribution Characteristics of Newly Discovered Gas Fields in China

    Institute of Scientific and Technical Information of China (English)

    Jin Yantai

    1997-01-01

    @@ The new gasfields and the increased gas reserves discovered in the last ten years (1986~1995) in China are characterized by zonation and relatively concentrated distribution both in plane and vertical directions.

  8. Scalable peer-to-peer resource discovering scheme for wireless self-organized networks

    Institute of Scientific and Technical Information of China (English)

    LI Xi; JI Hong

    2009-01-01

    Peer-to-peer technologies have attracted increasing research attention with fruitful protocols and applications proposed for wired networks. As to mobile environments, there are currently no mature deployments. A novel resource managing and discovering protocol, Cheer, is proposed to realize scalable and effective peer-to-peer lookup in wireless self-organized networks. Cheer resolves the topologies mismatch problem between peer-to-peer overlay networks and actual nodes distribution, allowing for frequent nodes membership changes. With specially designed resource storage table, Cheer also supports multikey and fuzzy lookup. Its hybrid architecture and improved routing scheme based on small-world theory may realize effective lookup routing. Theoretical analysis and simulation results both prove that Cheer makes using peer-to-peer applications in large-scale self-organized mobile networks feasible and promising.

  9. Depth-Resolved Cathodoluminescence of Thorium Dioxide

    Science.gov (United States)

    2013-03-01

    DEPTH-RESOLVED CATHODOLUMINESCENCE OF THORIUM DIOXIDE THESIS Michael G. Lee, Major, USA AFIT...RESOLVED CATHODOLUMINESCENCE OF THORIUM DIOXIDE THESIS Presented to the Faculty Department of Engineering Physics Graduate School of Engineering...PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT-ENP-13-M-21 DEPTH-RESOLVED CATHODOLUMINESCENCE OF THORIUM DIOXIDE Michael G. Lee, BS Major, USA Approved

  10. Maintaining Discovered Frequent Itemsets: Cases for Changeable Database and Support

    Institute of Scientific and Technical Information of China (English)

    DU XiaoPing(杜孝平); TANG ShiWei(唐世渭); Akifumi Makinouchi(牧之内顕文)

    2003-01-01

    Mining frequent itemsets from large databases has played an essential role inmany data mining tasks. It is also important to maintain the discovered frequent itemsets forthese data mining tasks when the database is updated. All algorithms proposed so far for the maintenance of discovered frequent itemsets are only performed with a fixed minimum support,which is the same as that used to obtain the discovered frequent itemsets. That is, users cannot change the minimum support even if the new results are unsatisfactory to the users. In thispaper two new complementary algorithms, FMP (First Maintaining Process) and RMP (Repeated Maintaining Process), are proposed to maintain discovered frequent itemsets in the case that new transaction data are added to a transaction database. Both algorithms allow users to change theminimum support for the maintenance processes. FMP is used for the first maintaining process, andwhen the result derived from the FMP is unsatisfactory, RMP will be performed repeatedly untilsatisfactory results are obtained. The proposed algorithms re-use the previous results to cut downthe cost of maintenance. Extensive experiments have been conducted to assess the performance of the algorithms. The experimental results show that the proposed algorithms are very resultful compared with the previous mining and maintenance algorithms for maintenance of discovered frequent itemsets.

  11. Chlorophyll d: the puzzle resolved

    DEFF Research Database (Denmark)

    Larkum, Anthony W D; Kühl, Michael

    2005-01-01

    Chlorophyll a (Chl a) has always been regarded as the sole chlorophyll with a role in photochemical conversion in oxygen-evolving phototrophs, whereas chlorophyll d (Chl d), discovered in small quantities in red algae in 1943, was often regarded as an artefact of isolation. Now, as a result...... of discoveries over the past year, it has become clear that Chl d is the major chlorophyll of a free-living and widely distributed cyanobacterium that lives in light environments depleted in visible light and enhanced in infrared radiation. Moreover, Chl d not only has a light-harvesting role but might also...... replace Chl a in the special pair of chlorophylls in both reactions centers of photosynthesis. Udgivelsesdato: 2005-Aug...

  12. The Magic of Mathematics Discovering the Spell of Mathematics

    CERN Document Server

    Pappas, Theoni

    2011-01-01

    Delves into the world of ideas, explores the spell mathematics casts on our lives, and helps you discover mathematics where you least expect it. Be spellbound by the mathematical designs found in nature. Learn how knots may untie the mysteries of life. Be mesmerized by the computer revolution. Discover how the hidden forces of mathematics hold architectural structures together connect your telephone calls help airplanes get off the ground solve the mysteries of the living cell. See how some artists use a mathematical palette in their works and how many writers draw upon the wealth of its ideas

  13. Fast Discovering Frequent Patterns for Incremental XML Queries

    Institute of Scientific and Technical Information of China (English)

    PENG Dun-lu; QIU Yang

    2004-01-01

    It is nontrivial to maintain such discovered frequent query patterns in real XML-DBMS because the transaction database of queries may allow frequent updates and such updates may not only invalidate some existing frequent query patterns but also generate some new frequent query patterns.In this paper, two incremental updating algorithms, FUXQMiner and FUFXQMiner, are proposed for efficient maintenance of discovered frequent query patterns and generation the new frequent query patterns when new XML queries are added into the database.Experimental results from our implementation show that the proposed algorithms have good performance.

  14. Automatically Discovering Relaxed Lyapunov Functions for Polynomial Dynamical Systems

    CERN Document Server

    Liu, Jiang; Zhao, Hengjun

    2011-01-01

    The notion of Lyapunov function plays a key role in design and verification of dynamical systems, as well as hybrid and cyber-physical systems. In this paper, to analyze the asymptotic stability of a dynamical system, we generalize standard Lyapunov functions to relaxed Lyapunov functions (RLFs), by considering higher order Lie derivatives of certain functions along the system's vector field. Furthermore, we present a complete method to automatically discovering polynomial RLFs for polynomial dynamical systems (PDSs). Our method is complete in the sense that it is able to discover all polynomial RLFs by enumerating all polynomial templates for any PDS.

  15. Highly Resolved Paleoclimatic Aerosol Records

    DEFF Research Database (Denmark)

    Kettner, Ernesto

    In ice cores a plethora of proxies for paleoclimatic conditions is archived. Air trapped in the ice during firnification allows for direct measurements of the concentrations and isotope ratios of paleoatmospheric gases while, the isotopic composition of the ice matrix itself is related...... to paleotemperatures. Impurities in the matrix are comprised of particulate and soluble aerosols, each carrying information on its source’s activitiy and|or proximity. Opposed to gases and water isotopes, the seasonality of many aerosols is not smoothed out in the firn column so that large concentration gradients...... with frequently changing signs are preserved. Therefore, these aerosol records can be used for dating by annual layer counting. However, with increasing depth the annual layer thicknesses decreases due to pressure and ice flow and accurate dating is possible only as long as the rapid variations can be resolved...

  16. Discovering Fuzzy Censored Classification Rules (Fccrs: A Genetic Algorithm Approach

    Directory of Open Access Journals (Sweden)

    Renu Bala

    2012-08-01

    Full Text Available Classification Rules (CRs are often discovered in the form of ‘If-Then’ Production Rules (PRs. PRs, beinghigh level symbolic rules, are comprehensible and easy to implement. However, they are not capable ofdealing with cognitive uncertainties like vagueness and ambiguity imperative to real word decision makingsituations. Fuzzy Classification Rules (FCRs based on fuzzy logic provide a framework for a flexiblehuman like reasoning involving linguistic variables. Moreover, a classification system consisting of simple‘If-Then’ rules is not competent in handling exceptional circumstances. In this paper, we propose aGenetic Algorithm approach to discover Fuzzy Censored Classification Rules (FCCRs. A FCCR is aFuzzy Classification Rule (FCRs augmented with censors. Here, censors are exceptional conditions inwhich the behaviour of a rule gets modified. The proposed algorithm works in two phases. In the firstphase, the Genetic Algorithm discovers Fuzzy Classification Rules. Subsequently, these FuzzyClassification Rules are mutated to produce FCCRs in the second phase. The appropriate encodingscheme, fitness function and genetic operators are designed for the discovery of FCCRs. The proposedapproach for discovering FCCRs is then illustrated on a synthetic dataset.

  17. Re-Discovering Mendel: The Case of Carl Correns

    Science.gov (United States)

    Rheinberger, Hans-Jörg

    2015-01-01

    Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of…

  18. Discovering Theorems in Abstract Algebra Using the Software "GAP"

    Science.gov (United States)

    Blyth, Russell D.; Rainbolt, Julianne G.

    2010-01-01

    A traditional abstract algebra course typically consists of the professor stating and then proving a sequence of theorems. As an alternative to this classical structure, the students could be expected to discover some of the theorems even before they are motivated by classroom examples. This can be done by using a software system to explore a…

  19. The Spy VI child : A newly discovered Neandertal infant

    NARCIS (Netherlands)

    Crevecoeur, Isabelle; Bayle, Priscilla; Rougier, Helene; Maureille, Bruno; Higham, Thomas; van der Plicht, Johannes; De Clerck, Nora; Semal, Patrick

    2010-01-01

    Spy cave (Jemeppe-sur-Sambre Belgium) is reputed for the two adult Neandertal individuals discovered in situ in 1886 Recent reassessment of the Spy collections has allowed direct radiocarbon dating of these individuals The sorting of all of the faunal collections has also led to the discovery of the

  20. US NSF: scientists discover planetary system similar to our own

    CERN Multimedia

    2003-01-01

    An international team of scientists has discovered a planet and star that may share the same relationship as Jupiter and our Sun, the closest comparison that researchers have found since they began their search for extra-solar planets nearly a decade ago (1 page).

  1. Scientists discover planetary system similar to our own

    CERN Multimedia

    2003-01-01

    'An international team of scientists has discovered a planet and star that may share the same relationship as Jupiter and our Sun, the closest comparison that researchers have found since they began their search for extra-solar planets nearly a decade ago' (1 page).

  2. Time resolved spectroscopy of GRB030501 using INTEGRAL

    CERN Document Server

    Beckmann, V; Courvoisier, Thierry J L; Goetz, D; Hudec, R; Hroch, F; Lund, N; Mereghetti, S; Shaw, S E; Wigger, C

    2003-01-01

    The Gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positiioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst Alert System in the ISGRI field of view. Although the burst was fairly weak (fluence F = 3.5 * 10^-6 erg cm^-2 in the 20-200 keV energy band) it was possible to perform time resolved spectroscopy with a resolution of a few seconds. The GRB shows a spectrum in the 20 - 400 keV range which is consistent with a spectral photon index of -1.7. No emission line or spectral break was detectable in the spectrum. Although the flux seems to be correlated with the hardness of the GRB spectrum, there is no clear soft to hard evolution seen over the duration of the burst. The INTEGRAL data have been compared with results from the Ulysses and RHESSI experiments.

  3. Fundamental Parameters of Some New Discovered Open star Clusters

    CERN Document Server

    El-Bendary, R

    2010-01-01

    We present here the fundamental properties of some newly discovered open star clusters (Teutsch 144, Alessi 53, Riddle 4 and Juchrt 12) using the JHK Near-IR photometry (2MASS survey) of Cutri et al. (2003). These clusters have been selected from Kronberger et al. (2006) who presented some new discovered stellar groups on the basis of 2MASS photometry and the DSS visual images. The astrometry and photometric parameters are determined using the stellar density distributions and color-magnitude diagrams fittings. Center, radius, membership, distances, reddening, age, luminosity function, mass function, total mass, and the dynamical relaxation time have been estimated for the first time. This paper is a part of Reda's PhD project.

  4. In Silico Models for Designing and Discovering Novel Anticancer Peptides

    Science.gov (United States)

    Tyagi, Atul; Kapoor, Pallavi; Kumar, Rahul; Chaudhary, Kumardeep; Gautam, Ankur; Raghava, G. P. S.

    2013-10-01

    Use of therapeutic peptides in cancer therapy has been receiving considerable attention in the recent years. Present study describes the development of computational models for predicting and discovering novel anticancer peptides. Preliminary analysis revealed that Cys, Gly, Ile, Lys, and Trp are dominated at various positions in anticancer peptides. Support vector machine models were developed using amino acid composition and binary profiles as input features on main dataset that contains experimentally validated anticancer peptides and random peptides derived from SwissProt database. In addition, models were developed on alternate dataset that contains antimicrobial peptides instead of random peptides. Binary profiles-based model achieved maximum accuracy 91.44% with MCC 0.83. We have developed a webserver, which would be helpful in: (i) predicting minimum mutations required for improving anticancer potency; (ii) virtual screening of peptides for discovering novel anticancer peptides, and (iii) scanning natural proteins for identification of anticancer peptides (http://crdd.osdd.net/raghava/anticp/).

  5. Newly discovered angiogenesis inhibitors and their mechanisms of action

    Institute of Scientific and Technical Information of China (English)

    Ze-hong MIAO; Jian-ming FENG; Jian DING

    2012-01-01

    In the past decade,the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy,During that time period,we have discovered and reported 17 compounds that exert potent inhibition on angiogenesis.These compounds exhibit tremendous diversity in their sources,structures,targets and mechanisms.These studies have generated new models for further modification and optimization of inhibitory compounds,new information for mechanistic studies and a new drug candidate for clinical development.In particular,through studies on the antiangiogenic mechanism of pseudolaric acid B,we discovered a novel mechanism by which the stability of hypoxia-irducible factor 1α is regulated by the transcription factor c-Jun.We also completed a preclinical study of AL3810,a compound with the potential to circumvent tumor drug resistance to a certain extent.All of these findings will be briefly reviewed in this article.

  6. Metagenomic approach for discovering new pathogens in infection disease outbreaks

    Directory of Open Access Journals (Sweden)

    Emanuela Giombini

    2011-09-01

    Full Text Available Viruses represent the most abundant biological components on earth.They can be found in every environment, from deep layers of oceans to animal bodies.Although several viruses have been isolated and sequenced, in each environment there are millions of different types of viruses that have not been identified yet.The advent of nextgeneration sequencing technologies with their high throughput capabilities make possible to study in a single experiment all the community of microorganisms present in a particular sample “microbioma”.They made more feasible the application of the metagenomic approach, by which it is also possible to discover and identify new pathogens, that may pose a threat to public health.This paper summarizes the most recent applications of nextgeneration sequencing to discover new viral pathogens during the occurrence of infection disease outbreaks.

  7. Hidden History: A Mobile Application for Discovering Surrounding Landscapes

    OpenAIRE

    2016-01-01

    This thesis work describes the design, development and evaluation of a mobile application called Hidden History. This application lets users discover and explore three types of landscapes (Historic, Scenic and Cultural) using three different modes of discovery (Route, Explore and Tour). Before designing Hidden History, the feature set of other applications that help users explore surrounding landscapes were identified and analyzed. Hidden History was then designed to implement the best fea...

  8. 2 new OT, discovered by MASTER-OAFA (Argentina)

    Science.gov (United States)

    Shumkov, V.; Lipunov, V.; Podesta, R.; Levato, H.; Gorbovskoy, E.; Tiurina, N.; Kuznetsov, A.; Vladimirov, V.; Balanutsa, P.; Kornilov, V.; Gress, O.; Chazov, V.; Kuvshinov, D.; Lopez, C.; Podesta, F.; Saffe, C.; Gabovich, A.

    2016-11-01

    MASTER-OAFA (located in Argentina) auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered OT source at (RA, Dec) = 09h 23m 26.72s -76d 28m 17.7s on 2016-11-13 06:19:38UT The OT magnitude in unfiltered is (mlim=18.0m).

  9. A Precious Fern Species Discovered in Jiulong, Sichuan

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Supported by the US National Science Foundation and the National Natural Science Foundation of China, a rare and endangered fern, Isoetes hypsophila, was discovered by a Sino-US research team headed by Prof. SUN Hang from the CAS Kunming Institute of Botany (KIB) and Dr. David E. Boufford from Harvard University in a recent trip to Jiulong, Sichuan, during its botanical survey in the Hengduan Mountains in south China. Scientists say the plant is found for the first time in the region.

  10. Discovering Site-Specific Qualities in Venice and Marseille

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2015-01-01

    When “site-specificity” becomes a central value in city and harbor transfor-mation, it soon proves necessary to address the ways in which scholars and professionals actually come to determine site-specific qualities in urban fab-rics and social life. How are certain traits and habits discovered...... aspects in urban fabric and con-temporary life. Thanks to site-specific features, self-reflexive approaches to harbor transformation may develop....

  11. Zhangpeishanite, a new mineral discovered in Baiyun Obo mine

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Hidehiko National Shimazaki and his colleagues from Japan Museum of Nature and Science collaborated with Yang Zhuming, researcher of Institute of Geology and Geophysics, Chinese Academy of Sciences, discovered a new type of mineral in Baiyun Obo mine in Inner Mongolia Autonomous Region one year ago. This new mineral, reviewed and approved by the Commission on New Minerals, Nomenclature and Classification (CNMNC) of International Mineralogical Association (IMA), was named Zhangpeishanite.

  12. Heilongjiang discovered a number of non ferrous metal mineral locations

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Non-ferrous Metal Geological Exploration Bu- reau of Heilongjiang Province achieved signifi- cant mine searching results in 2007:estimation and forecast of resource reserves covered 60,000 tons of Molybdenum,70,000 tons of copper,9 million tons of iron,2.9 tons of gold, 250 tons of silver,and 80,000 tons of lead and zinc.Newly discovered metal mine locations

  13. Discovering the quantum universe the role of particle colliders

    CERN Document Server

    2006-01-01

    What does "Quantum Universe" mean? To discover what the universe is made of and how it works is the challenge of particle physics. "Quantum Universe" defines the quest to explain the universe in terms of quantum physics, which governs the behavior of the microscopic, subatomic world. It describes a revolution in particle physics and a quantum leap in our understanding of the mystery and beauty of the universe.

  14. Discovering health topics in social media using topic models.

    Directory of Open Access Journals (Sweden)

    Michael J Paul

    Full Text Available By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM, as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689 and allergies (r = 0.810 temporal surveillance data, as well as exercise (r =  .534 and obesity (r =  -.631 related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  15. Discovering Equations in Relation of Process to the Counseling Process

    Directory of Open Access Journals (Sweden)

    Hideaki Yanagisawa

    2015-05-01

    Full Text Available Each counselor understands counseling freely as all counseling theories are explained without equations. Therefore, there are two kinds of mistakes in counseling. One is counter-transference, the other is a mistake wherein the counselor forces his thought and induces certain thoughts in the client. The counselor assists in aiding the client’s real intentions to be converted to the client’s consciousness from their unconsciousness. It is equal to a process in which the methods rearrange and unify the thoughts from a chaotic state. For example, such methods include the KJ (Kawakida Jiro method, the SEIQoL-DW (Schedule for the Evaluation of Individual Quality of Life-Direct Weighting method, dialectics, the process discovering equation. In this report, the counseling process is compared with a process of discovering equations from observed values. In the process of discovering equations, it is important that the curve of equations smoothly continues. On the curve, the contact point and the gradient of the tangent line must not break off. Similarly, it is important that a counselor easily understands a client. Therefore, it is a necessary condition for counseling that the counselor’s and client’s original characters are smoothly patterned and that the communicating method of the counselor must be equal to that of the client. It will be useful for preventing two kinds of mistakes in counseling if counseling can be represented using equations and graphs.

  16. Discovering System Health Anomalies Using Data Mining Techniques

    Science.gov (United States)

    Sriastava, Ashok, N.

    2005-01-01

    We present a data mining framework for the analysis and discovery of anomalies in high-dimensional time series of sensor measurements that would be found in an Integrated System Health Monitoring system. We specifically treat the problem of discovering anomalous features in the time series that may be indicative of a system anomaly, or in the case of a manned system, an anomaly due to the human. Identification of these anomalies is crucial to building stable, reusable, and cost-efficient systems. The framework consists of an analysis platform and new algorithms that can scale to thousands of sensor streams to discovers temporal anomalies. We discuss the mathematical framework that underlies the system and also describe in detail how this framework is general enough to encompass both discrete and continuous sensor measurements. We also describe a new set of data mining algorithms based on kernel methods and hidden Markov models that allow for the rapid assimilation, analysis, and discovery of system anomalies. We then describe the performance of the system on a real-world problem in the aircraft domain where we analyze the cockpit data from aircraft as well as data from the aircraft propulsion, control, and guidance systems. These data are discrete and continuous sensor measurements and are dealt with seamlessly in order to discover anomalous flights. We conclude with recommendations that describe the tradeoffs in building an integrated scalable platform for robust anomaly detection in ISHM applications.

  17. DISCOVER-AQ: An Overview and Initial Comparisons of NO2 with OMI Observations

    Science.gov (United States)

    Pickering, Kenneth; Crawford, James; Krotkov, Nickolay; Bucsela, Eric; Lamsal, Lok; Celarier, Edward; Herman, Jay; Janz, Scott; Cohen, Ron; Weinheimer, Andrew

    2011-01-01

    The first deployment of the Earth Venture -1 DISCOVER-AQ (Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality) project was conducted during July 2011 in the Baltimore-Washington region. Two aircraft (a P-3B for in-situ sampling and a King Air for remote sensing) were used along with an extensive array of surface-based in-situ and remote sensing instrumentation. Fourteen flight days were accomplished by both aircraft and over 250 profiles of trace gases and aerosols were performed by the P-3B over surface air quality monitoring stations, which were specially outfitted with sunphotometers and Pandora UV/Vis spectrometers. The King Air flew with the High Spectral Resolution Lidar for aerosols and the ACAM UV/Vis spectrometer for trace gases. This suite of observations allows linkage of surface air quality with the vertical distributions of gases and aerosols, with remotely-sensed column amounts observed from the surface and from the King Air, and with satellite observations from Aura (OMI and TES), GOME-2, MODIS and GOES. The DISCOVER-AQ data will allow determination of under what conditions satellite retrievals are indicative of surface air quality, and they will be useful in planning new satellites. In addition to an overview of the project, a preliminary comparison of tropospheric column NO2 densities from the integration of in-situ P-3B observations, from the Pandoras and ACAM, and from the new Goddard OMI NO2 algorithm will be presented.

  18. Tools and strategies for discovering novel enzymes and metabolic pathways

    Directory of Open Access Journals (Sweden)

    John A. Gerlt

    2016-12-01

    Full Text Available The number of entries in the sequence databases continues to increase exponentially – the UniProt database is increasing with a doubling time of ∼4 years (2% increase/month. Approximately 50% of the entries have uncertain, unknown, or incorrect function annotations because these are made by automated methods based on sequence homology. If the potential in complete genome sequences is to be realized, strategies and tools must be developed to facilitate experimental assignment of functions to uncharacterized proteins discovered in genome projects. The Enzyme Function Initiative (EFI; previously supported by U54GM093342 from the National Institutes of Health, now supported by P01GM118303 developed web tools for visualizing and analyzing (1 sequence and function space in protein families (EFI-EST and (2 genome neighbourhoods in microbial and fungal genomes (EFI-GNT to assist the design of experimental strategies for discovering the in vitro activities and in vivo metabolic functions of uncharacterized enzymes. The EFI developed an experimental platform for large-scale production of the solute binding proteins (SBPs for ABC, TRAP, and TCT transport systems and their screening with a physical ligand library to identify the identities of the ligands for these transport systems. Because the genes that encode transport systems are often co-located with the genes that encode the catabolic pathways for the transported solutes, the identity of the SBP ligand together with the EFI-EST and EFI-GNT web tools can be used to discover new enzyme functions and new metabolic pathways. This approach is demonstrated with the characterization of a novel pathway for ethanolamine catabolism.

  19. Discovering Astronomy: An Astro 101 e-book

    Science.gov (United States)

    Shawl, Stephen J.; Byrd, Gene; Deustua, Susana E.; LoPresto, Michael C.

    2016-01-01

    Discovering Astronomy, now available in its 6th edition as an eText, has many advantages and features for your students. We have partnered with etextink.com and WebAssign.net to produce an affordable set of cost-saving options for your students. Also available is the Discovering Astronomy Activity Manual, which provides students with an active-learning experience.Our etext is device independent and thus accessible through any web browser. Americans with Disabilities Act compatibility provides access for all students. Hotlinks to outside sites provide further information for interested students. Lecture demonstration videos of important concepts, made specifically for this new edition, are embedded within the text as appropriate. Students can highlight text, take notes, and bookmark locations within the text. Important terms are linked to the glossary. Search capabilities allow students to easily find what they want.Instructors can interact with their students directly through the etext once the class roster has been provided. For example, instructors can embed assignments into their students' etext and add their own notes and updates, which are immediately visible to their students.Updates can be quickly made by us as new findings become available. For example, updates from New Horizons were added at the time of the closest approach to Pluto, and an update on the recent announcement of current water on Mars was added the day of the announcement.We will present results of our own experience with college and high school students' use of Discovering Astronomy in online courses.Details of the book, a sample chapter, and other information are available at discoveringastronomy.weebly.com.

  20. Knots and surfaces a guide to discovering mathematics

    CERN Document Server

    Farmer, David W

    1995-01-01

    In most mathematics textbooks, the most exciting part of mathematics-the process of invention and discovery-is completely hidden from the reader. The aim of Knots and Surfaces is to change all that. By means of a series of carefully selected tasks, this book leads readers to discover some real mathematics. There are no formulas to memorize; no procedures to follow. The book is a guide: its job is to start you in the right direction and to bring you back if you stray too far. Discovery is left to you. Suitable for a one-semester course at the beginning undergraduate level, there are no prerequi

  1. Astrophysical parameters of ten new discovered open star clusters

    CERN Document Server

    Tadross, A L; Osman, A; Ismail, N; Bakry, A

    2011-01-01

    We present here the fundamental parameters of ten open star clusters, nominated from Kronberger et al. (2006) who presented some new discovered stellar groups on the basis of 2MASS photometry and DSS visual images. Star counts and photometric parameters (radius, membership, distances, color excess, age, luminosity function, mass function, total mass, and the dynamical relaxation time) have been determined for these ten clusters for the first time. In order to calibrate our procedures, the main parameters (distance, age, and color excesses) have been re-estimated for another five clusters, which are studied by Kronberger et al. (2006) as well.

  2. An approach for discovering keywords from Spanish tweets using Wikipedia

    Directory of Open Access Journals (Sweden)

    Daniel AYALA

    2016-05-01

    Full Text Available Most approaches to keywords discovery when analyzing microblogging messages (among them those from Twitter are based on statistical and lexical information about the words that compose the text. The lack of context in the short messages can be problematic due to the low co-occurrence of words. In this paper, we present a new approach for keywords discovering from Spanish tweets based on the addition of context information using Wikipedia as a knowledge base. We present four different ways to use Wikipedia and two ways to rank the new keywords. We have tested these strategies using more than 60000 Spanish tweets, measuring performance and analyzing particularities of each strategy.

  3. Discovering New Oilfield within 18 Months Using Integrated Geophysical Technology

    Institute of Scientific and Technical Information of China (English)

    JiLiansheng; KongFanshu; SunJianchen

    2003-01-01

    The Yanqi basin is small and located at the northeastern corner of the Tarim basin. Before April 1993, the Yanqi basin was only surveyed with surface geology and seldom known among the explorers. After that, the gravitational, magnetic and MT prospecting were carried out and found some interesting local structures, which might be oil-and-gas-bearing. A few seismic lines were utilized to confirm them. An exploratory well was drilled in the summer of 1994 and discovered oil flow with industrial value in Oct., the same year. The petroleum exploration obtained breakthrough in the Yanqi basin in only 18 months.

  4. Growing Self-Estemm and Discovering Intelligences through Oral Production

    Directory of Open Access Journals (Sweden)

    Ochoa Dora Liliana

    2002-08-01

    Full Text Available After having applied a needs analysis in an eleventh grade course of English, I could notice that there was a big lack of security and self-confidence in the students. They expressed in different data-gathering instruments their fear when speaking in front of the class. Also, they talked about their insecurity when pronouncing English and the need for more opportunities for developing speaking. Therefore, the implementation of an innovation in class was carried out in order to respond to the students¿ needs and make them discover their talents. The implementation was successful and students improved some areas of their communicative competence.

  5. Sir Alexander Fleming: Scottish researcher who discovered penicillin.

    Science.gov (United States)

    Ligon, B Lee

    2004-01-01

    The discovery and development of penicillin changed the entire direction of approaches to treating infectious diseases and saved the lives of millions of people. Indeed, the development of penicillin was a watershed event in the battle against infectious diseases, and the individual who discovered it, Sir Alexander Fleming, remains a prominent individual in the annals of medical history. This article focuses primarily on the personal life of Alexander Fleming, an individual who had a remarkable diversity of interests and who made many contributions to science and medicine.

  6. Discovering Communicable Scientific Knowledge from Spatio-Temporal Data

    Science.gov (United States)

    Schwabacher, Mark; Langley, Pat; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper describes how we used regression rules to improve upon a result previously published in the Earth science literature. In such a scientific application of machine learning, it is crucially important for the learned models to be understandable and communicable. We recount how we selected a learning algorithm to maximize communicability, and then describe two visualization techniques that we developed to aid in understanding the model by exploiting the spatial nature of the data. We also report how evaluating the learned models across time let us discover an error in the data.

  7. Electron–Rotor Interaction in Organic–Inorganic Lead Iodide Perovskites Discovered by Isotope Effects

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Jue; Yang, Mengjin; Ma, Xiangchao; Schaller, Richard D.; Liu, Gang; Kong, Lingping; Yang, Ye; Beard, Matthew C.; Lesslie, Michael; Dai, Ying; Huang, Baibiao; Zhu, Kai; Xu, Tao

    2016-08-04

    We report on the carrier-rotor coupling effect in perovskite organic-inorganic hybrid lead iodide (CH3NH3PbI3) compounds discovered by isotope effects. Deuterated organic-inorganic perovskite compounds including CH3ND3PbI3, CD3NH3PbI3, and CD3ND3PbI3 were synthesized. Devices made from regular CH3NH3PbI3 and deuterated CH3ND3PbI3 exhibit comparable performance in band gap, current-voltage, carrier mobility, and power conversion efficiency. However, a time-resolved photoluminescence (TRPL) study reveals that CH3NH3PbI3 exhibits notably longer carrier lifetime than that of CH3ND3PbI3, in both thin-film and single-crystal formats. Furthermore, the comparison in carrier lifetime between CD3NH3PbI3 and CH3ND3PbI3 single crystals suggests that vibrational modes in methylammonium (MA+) have little impact on carrier lifetime. In contrast, the fully deuterated compound CD3ND3PbI3 reconfirmed the trend of decreasing carrier lifetime upon the increasing moment of inertia of cationic MA+. Polaron model elucidates the electron-rotor interaction.

  8. Learning Faster by Discovering and Exploiting Object Similarities

    Directory of Open Access Journals (Sweden)

    Tadej Janež

    2013-03-01

    Full Text Available In this paper we explore the question: “Is it possible to speed up the learning process of an autonomous agent by performing experiments in a more complex environment (i.e., an environment with a greater number of different objects?” To this end, we use a simple robotic domain, where the robot has to learn a qualitative model predicting the change in the robot’s distance to an object. To quantify the environment’s complexity, we defined cardinal complexity as the number of objects in the robot’s world, and behavioural complexity as the number of objects’ distinct behaviours. We propose Error reduction merging (ERM, a new learning method that automatically discovers similarities in the structure of the agent’s environment. ERM identifies different types of objects solely from the data measured and merges the observations of objects that behave in the same or similar way in order to speed up the agent’s learning. We performed a series of experiments in worlds of increasing complexity. The results in our simple domain indicate that ERM was capable of discovering structural similarities in the data which indeed made the learning faster, clearly superior to conventional learning. This observed trend occurred with various machine learning algorithms used inside the ERM method.

  9. Novel virophages discovered in a freshwater lake in China

    Directory of Open Access Journals (Sweden)

    Chaowen eGong

    2016-01-01

    Full Text Available Virophages are small double-stranded DNA viruses that are parasites of giant DNA viruses that infect unicellular eukaryotes. Here we identify a novel group of virophages, named Dishui Lake virophages (DSLVs that were discovered in Dishui Lake (DSL: an artificial freshwater lake in Shanghai, China. Based on PCR and metagenomic analysis, the complete genome of DSLV1 was found to be circular and 28,788 base pairs in length, with a G+C content 43.2%, and 28 predicted open reading frames (ORFs. Fifteen of the DSLV1 ORFs have sequence similarity to known virophages. Two DSLV1 ORFs exhibited sequence similarity to that of prasinoviruses (Phycodnaviridae and chloroviruses (Phycodnaviridae, respectively, suggesting horizontal gene transfer occurred between these large algal DNA viruses and DSLV1. 46 other virophages-related contigs were also obtained, including six homologous major capsid protein (MCP gene. Phylogenetic analysis of these MCPs showed that DSLVs are closely related to OLV (Organic Lake virophage and YSLVs (Yellowstone Lake virophages, especially to YSLV3, except for YSLV7. These results indicate that freshwater ecotopes are the hotbed for discovering novel virophages as well as understanding their diversity and properties.

  10. NEOKepler: Discovering Near-Earth Objects Using the Kepler Spacecraft

    CERN Document Server

    Stevenson, Kevin B; Jedicke, Robert; Bottke, William; Denneau, Larry

    2013-01-01

    We propose a new Kepler mission, called NEOKepler, that would survey near Earth's orbit to identify potentially hazardous objects (PHOs). To understand its surveying power, Kepler's large field of view produces an 'etendue' (A*Omega) that is 4.5 times larger than the best survey telescope currently in operation. In this paper, we investigate the feasibility of NEOKepler using a double "fence post" survey pattern that efficiently detects PHOs. In a simulated 12-month survey, we estimate that NEOKepler would detect ~150 new NEOs with absolute magnitudes of less than 21.5, ~50 of which would be new PHOs. This would increase the annual PHO discovery rate by at least 50% and improve upon our goal of discovering 90% of PHOs by the end of 2020. Due to its heliocentric orbit, Kepler would also be sensitive to objects inside Earth's orbit, discovering more objects in its first year than are currently known to exist. Understanding this undersampled sub-population of NEOs will reveal new insights into the actual PHO dis...

  11. Component resolved testing for allergic sensitization

    DEFF Research Database (Denmark)

    Skamstrup Hansen, Kirsten; Poulsen, Lars K

    2010-01-01

    Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergi...

  12. Time resolved studies of bond activation by organometallic complexes

    Energy Technology Data Exchange (ETDEWEB)

    Wilkens, Matthew J. [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry

    1998-05-01

    In 1971, Jetz and Graham discovered that the silicon-hydrogen bond in silanes could be broken under mild photochemical conditions in the presence of certain transition metal carbonyls. Such reactions fall within the class of oxidative addition. A decade later, similar reactivity was discovered in alkanes. In these cases a C-H bond in non-functionalized alkanes was broken through the oxidative addition of Cp*Ir(H)2L (Cp* = (CH3)5C5, L = PPh3, Ph = C6H5) to form Cp*ML(R)(H) or of Cp*Ir(CO)2 to form Cp*Ir(CO)(R)(H). These discoveries opened an entirely new field of research, one which naturally included mechanistic studies aimed at elucidating the various paths involved in these and related reactions. Much was learned from these experiments but they shared the disadvantage of studying under highly non-standard conditions a system which is of interest largely because of its characteristics under standard conditions. Ultrafast time-resolved IR spectroscopy provides an ideal solution to this problem; because it allows the resolution of chemical events taking place on the femto-through picosecond time scale, it is possible to study this important class of reactions under the ambient conditions which are most of interest to the practicing synthetic chemist. Certain of the molecules in question are particularly well-suited to study using the ultrafast IR spectrophotometer described in the experimental section because they contain one or more carbonyl ligands.

  13. Time resolved studies of bond activation by organometallic complexes

    Energy Technology Data Exchange (ETDEWEB)

    Wilkens, M J [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry

    1998-05-01

    In 1971, Jetz and Graham discovered that the silicon-hydrogen bond in silanes could be broken under mild photochemical conditions in the presence of certain transition metal carbonyls. Such reactions fall within the class of oxidative addition. A decade later, similar reactivity was discovered in alkanes. In these cases a C-H bond in non-functionalized alkanes was broken through the oxidative addition of Cp*Ir(H){sub 2}L (Cp* = (CH{sub 3}){sub 5}C{sub 5}, L = PPh{sub 3}, Ph = C{sub 6}H{sub 5}) to form Cp*ML(R)(H) or of Cp*Ir(CO){sub 2} to form Cp*Ir(CO)(R)(H). These discoveries opened an entirely new field of research, one which naturally included mechanistic studies aimed at elucidating the various paths involved in these and related reactions. Much was learned from these experiments but they shared the disadvantage of studying under highly non-standard conditions a system which is of interest largely because of its characteristics under standard conditions. Ultrafast time-resolved IR spectroscopy provides an ideal solution to this problem; because it allows the resolution of chemical events taking place on the femto-through picosecond time scale, it is possible to study this important class of reactions under the ambient conditions which are most of interest to the practicing synthetic chemist. Certain of the molecules in question are particularly well-suited to study using the ultrafast IR spectrophotometer described in the experimental section because they contain one or more carbonyl ligands.

  14. A systematic approach to discover and characterize natural plant biostimulants

    Directory of Open Access Journals (Sweden)

    Giovanni ePovero

    2016-04-01

    Full Text Available The use of natural plant biostimulants is proposed as an innovative solution to address the challenges to sustainable agriculture, to ensure optimal nutrient uptake, crop yield, quality, and tolerance to abiotic stress. However, the process of selection and characterization of plant biostimulant matrices is complex and involves a series of rigorous evaluations customized to the needs of the plant.Here, we propose a highly differentiated plant biostimulant development and production platform, which involves a combination of technology, processes, and know-how. Chemistry, biology and omic concepts are combined/integrated to investigate and understand the specific mode(s of action of bioactive ingredients. The proposed approach allows to predict and characterize the function of natural compounds as biostimulants. By managing and analyzing massive amounts of complex data, it is therefore possible to discover, evaluate and validate new product candidates, thus expanding the uses of existing products to meet the emerging needs of agriculture.

  15. Active Galactic Nuclei Discovered in the Kepler Mission

    CERN Document Server

    Shaya, Edward J; Mushotzky, Richard

    2015-01-01

    We report on candidate active galactic nuclei (AGN) discovered during the monitoring of $\\sim$500 bright (r < 18 mag) galaxies over several years with the Kepler Mission. Most of the targets were sampled every 30 minutes nearly continuously for a year or more. Variations of 0.001 mag and often less could be detected reliably. About 4.0% (19) of our random sample continuously fluctuated with amplitudes increasing with longer timescales, but the majority are close to the limits of detectability with Kepler. We discuss our techniques to mitigate the long term instrumental trends in Kepler light curves and our resulting structure function curves. The amplitudes of variability over four month periods, as seen in the structure functions and PSDs, can dramatically change for many of these AGN candidates. Four of the candidates have features in their Structure Functions that may indicate quasi-periodic behavior, although other possibilities are discussed.

  16. Quantify spatial relations to discover handwritten graphical symbols

    Science.gov (United States)

    Li, Jinpeng; Mouchère, Harold; Viard-Gaudin, Christian

    2012-01-01

    To model a handwritten graphical language, spatial relations describe how the strokes are positioned in the 2-dimensional space. Most of existing handwriting recognition systems make use of some predefined spatial relations. However, considering a complex graphical language, it is hard to express manually all the spatial relations. Another possibility would be to use a clustering technique to discover the spatial relations. In this paper, we discuss how to create a relational graph between strokes (nodes) labeled with graphemes in a graphical language. Then we vectorize spatial relations (edges) for clustering and quantization. As the targeted application, we extract the repetitive sub-graphs (graphical symbols) composed of graphemes and learned spatial relations. On two handwriting databases, a simple mathematical expression database and a complex flowchart database, the unsupervised spatial relations outperform the predefined spatial relations. In addition, we visualize the frequent patterns on two text-lines containing Chinese characters.

  17. [Recently discovered hormones with a role in energy homeostasis].

    Science.gov (United States)

    Krykorková, I; Nedvídková, J

    2003-02-01

    Adipocytal hormones resistin and adiponectin and gastric peptide ghrelin are recently discovered hormones, which are considered to take part in energy metabolism regulation. Resistin is expressed in adipose tissue only and its increased levels could cause insulin resistance and thus link obesity with type 2 diabetes. Adiponectin, as well as resistin, are products of genes, expressed in adipose tissue. Adiponectin could prevent development of aterosclerosis and it could play a role in anti-inflammatory reactions. Ghrelin is produced mainly in the stomach. Beside its role in long-term regulation of energy metabolism, it is involved in the short-term regulation of feeding. Main roles of resistin, adiponectin and ghrelin are summarised in the presented overview.

  18. Discovering Frequent Subtrees from XML Data Using Neural Networks

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    By rapid progress of network and storage technologies, a huge amount of electronic data such as Web pages and XML has been available on Internet. In this paper, we study a data-mining problem of discovering frequent ordered sub-trees in a large collection of XML data, where both of the patterns and the data are modeled by labeled ordered trees. We present an efficient algorithm of Ordered Subtree Miner(OSTMiner) based on two- layer neural networks with Hebb rule, that computes all ordered sub-trees appearing in a collection of XML trees with frequent above a user-specified threshold using a special structure EM-tree. In this algorithm, EM-tree is used as an extended merging tree to supply scheme information for efficient pruning and mining frequent sub-trees. Experiments results showed that OSTMiner has good response time and scales well.

  19. How did Archimedes discover the law of buoyancy by experiment?

    Science.gov (United States)

    Kuroki, Hidetaka

    2016-03-01

    After Archimedes and Vitruvius era, for more than 2000 years, it has been believed that the displaced water measurement of golden crown is impossible, and at his Eureka moment, Archimedes discovered the law of buoyancy (Proposition 7 of his principles) and proved the theft of a goldsmith by weighing the golden crown in water. A previous study showed that a small amount of displaced water was able to be measured with enough accuracy by the introduced method. Archimedes measured the weight of displaced water. He did not find the law of buoyancy but rather specific gravity of things at the moment. After which, Archimedes continued to measure the specific gravity of various solids and fluids. Through these measurements, he reached the discovery of the law of buoyancy directly by experiment. In this paper, the process to the discovery of Archimedes' principle (Proposition 5) is presented.

  20. Discovering opinion leaders for medical topics using news articles

    Directory of Open Access Journals (Sweden)

    Jonnalagadda Siddhartha

    2012-03-01

    Full Text Available Abstract Background Rapid identification of subject experts for medical topics helps in improving the implementation of discoveries by speeding the time to market drugs and aiding in clinical trial recruitment, etc. Identifying such people who influence opinion through social network analysis is gaining prominence. In this work, we explore how to combine named entity recognition from unstructured news articles with social network analysis to discover opinion leaders for a given medical topic. Methods We employed a Conditional Random Field algorithm to extract three categories of entities from health-related new articles: Person, Organization and Location. We used the latter two to disambiguate polysemy and synonymy for the person names, used simple rules to identify the subject experts, and then applied social network analysis techniques to discover the opinion leaders among them based on their media presence. A network was created by linking each pair of subject experts who are mentioned together in an article. The social network analysis metrics (including centrality metrics such as Betweenness, Closeness, Degree and Eigenvector are used for ranking the subject experts based on their power in information flow. Results We extracted 734,204 person mentions from 147,528 news articles related to obesity from January 1, 2007 through July 22, 2010. Of these, 147,879 mentions have been marked as subject experts. The F-score of extracting person names is 88.5%. More than 80% of the subject experts who rank among top 20 in at least one of the metrics could be considered as opinion leaders in obesity. Conclusion The analysis of the network of subject experts with media presence revealed that an opinion leader might have fewer mentions in the news articles, but a high network centrality measure and vice-versa. Betweenness, Closeness and Degree centrality measures were shown to supplement frequency counts in the task of finding subject experts. Further

  1. Discovering Tradeoffs, Vulnerabilities, and Dependencies within Water Resources Systems

    Science.gov (United States)

    Reed, P. M.

    2015-12-01

    There is a growing recognition and interest in using emerging computational tools for discovering the tradeoffs that emerge across complex combinations infrastructure options, adaptive operations, and sign posts. As a field concerned with "deep uncertainties", it is logically consistent to include a more direct acknowledgement that our choices for dealing with computationally demanding simulations, advanced search algorithms, and sensitivity analysis tools are themselves subject to failures that could adversely bias our understanding of how systems' vulnerabilities change with proposed actions. Balancing simplicity versus complexity in our computational frameworks is nontrivial given that we are often exploring high impact irreversible decisions. It is not always clear that accepted models even encompass important failure modes. Moreover as they become more complex and computationally demanding the benefits and consequences of simplifications are often untested. This presentation discusses our efforts to address these challenges through our "many-objective robust decision making" (MORDM) framework for the design and management water resources systems. The MORDM framework has four core components: (1) elicited problem conception and formulation, (2) parallel many-objective search, (3) interactive visual analytics, and (4) negotiated selection of robust alternatives. Problem conception and formulation is the process of abstracting a practical design problem into a mathematical representation. We build on the emerging work in visual analytics to exploit interactive visualization of both the design space and the objective space in multiple heterogeneous linked views that permit exploration and discovery. Many-objective search produces tradeoff solutions from potentially competing problem formulations that can each consider up to ten conflicting objectives based on current computational search capabilities. Negotiated design selection uses interactive visualization

  2. Kuranakhite Discovered in China for the First Time

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Kuranakhite was firstly discovered in the oxidezed zone of the Kuranakh gold mine,southern Russia,and since thewn there has been no report on it .Kuranakhite in this paper was discovered in the Jialu gold mine,Luonan,County,Shaanxi Province,The mineral often occurs as irregular granular aggregates varying from 0.05 to 0.25 mm in size.The mineral is light brown to brown in color,translucent,brown in steak,and vitreous in luster,Hv is 231-439kg/mm2,HM=4-5 and measured density is 6.72(2)g/cm3,Its reflection color is bluish gray to light-blue and it shows middle anisotropism and weak bireflectance.Its polarization color is blue to grayish-brown and there is no internal reflection.The index of refraction is: Na=2.01,Nβ=1.98,Nγ=1.96,The average composition is PbO 45.40wt%,MnO2 16.41wt%,TeO3 38.10wt%,totalling 99.91wt%,the empirical formula is Pb0.99 Mn0.92Te1.06O6,which can be simplified as PbMnTeO6.Principal lines in the X-ray power pattern[d(I)(hkl)]are:0.341(100),(111);0.2556(60),(130),0.2043(50),(041);0.1666(20),(310);0.1598(40),(241),and 0.1472(15),(330),It was determined that kuranakhite is orthorhombic;its space group may be C;a=0.511(1)nm,b=0.891(2)nm,c=0.532(1)nm,a:b=0.57,c:b=0.60;V=0.242(3)nm3;z=2,and calculated density=6.66(1)g/cm3.

  3. PTF1 J191905.19+481506.2 - A Partially Eclipsing AM CVn System Discovered in the Palomar Transient Factory

    CERN Document Server

    Levitan, David; Groot, Paul J; Margon, Bruce; Prince, Thomas A; Kulkarni, Shrinivas R; Hallinan, Gregg; Harding, Leon K; Kyne, Gillian; Laher, Russ; Ofek, Eran O; Rutten, René G M; Sesar, Branimir; Surace, Jason

    2014-01-01

    We report on PTF1 J191905.19+481506.2, a newly discovered, partially eclipsing, outbursting AM CVn system found in the Palomar Transient Factory synoptic survey. This is only the second known eclipsing AM CVn system. We use high-speed photometric observations and phase-resolved spectroscopy to establish an orbital period of 22.4559(3) min. We also present a long-term light curve and report on the normal and super-outbursts regularly seen in this system, including a super-outburst recurrence time of 36.8(4) d. We use the presence of the eclipse to place upper and lower limits on the inclination of the system and discuss the number of known eclipsing AM CVn systems versus what would be expected.

  4. Phase-resolved polarization properties of the pulsar striped wind synchrotron emission

    CERN Document Server

    Petri, J

    2013-01-01

    Since the launch of the Fermi telescope more than five years ago, many new gamma-ray pulsars have been discovered with intriguing properties challenging our current understanding of pulsar physics. Observation of the Crab pulsar furnish today a broad band analysis of the pulsed spectrum with phase-resolved variability allowing to refine existing model to explain pulse shape, spectra and polarization properties. The latter gives inside into the geometry of the emitting region as well as on the structure of the magnetic field. Based on an exact analytical solution of the striped wind with finite current sheet thickness, we analyze in detail the phase-resolved polarization variability emanating from the synchrotron radiation. We assume that the main contribution to the wind emissivity comes from a thin transition layer where the dominant toroidal magnetic field reverses its polarity, the so-called current sheet. The resulting radiation is mostly linearly polarized. In the off-pulse region, the electric vector li...

  5. Spatially-Resolved Spectra of the "Teacup" AGN: Tracing the History of a Dying Quasar

    CERN Document Server

    Gagne, J P; Kraemer, S B; Schmitt, H R; Keel, W C; Rafter, S; Fischer, T C; Bennert, V N; Schawinski, K

    2014-01-01

    The Sloan Digital Sky Survey (SDSS) Galaxy Zoo project has revealed a number of spectacular galaxies possessing Extended Emission-Line Regions (EELRs), the most famous being Hanny's Voorwerp galaxy. We present another EELR object discovered in the SDSS endeavor: the Teacup Active Galactic Nucleus (AGN), nicknamed for its EELR, which has a handle like structure protruding 15 kpc into the northeast quadrant of the galaxy. We analyze physical conditions of this galaxy with long-slit ground based spectroscopy from Lowell, Lick, and KPNO observatories. With the Lowell 1.8m Perkin's telescope we took multiple observations at different offset positions, allowing us to recover spatially resolved spectra across the galaxy. Line diagnostics indicate the ionized gas is photoionized primarily by the AGN. Additionally we are able to derive the hydrogen density from the [S II] 6716/6731 ratio. We generated two-component photoionization models for each spatially resolved Lowell spectrum. These models allow us to calculate t...

  6. Assessment of emerging contaminants including organophosphate esters and pyrethroids during DISCOVER-AQ in Houston, Texas, United States.

    Science.gov (United States)

    Usenko, Sascha; Clark, Addie; Sheesley, Rebecca

    2015-04-01

    DISCOVER-AQ (Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality) is a NASA-funded air quality research program that focused on Houston, Texas, United States in September 2013. In conjunction with DISCOVER-AQ, particulate matter was collected for the month of September from four ground-based sampling sites across the Houston metropolitan area. The Houston metropolitan area is one of the most populous cities in the United States. Sampling sites included an upwind and downwind site as well as an urban (i.e. downtown) and industrial/port areas (i.e. Houston Ship Channel). Particulate matter samples were collected to examine both spatial and temporal trends (including day versus night). Particulate matter was collected on quartz fiber filters, which were analyzed for emerging classes of concern including organophosphate esters (OPEs; including flame retardants) and pyrethroids. OPEs have in recent years increased in both use and production as they replaced polybrominated diphenyl ethers flame retardants. Permethrin is one of the most commonly used mosquito adulticides in the United States.

  7. The conforming brain and deontological resolve.

    Directory of Open Access Journals (Sweden)

    Melanie Pincus

    Full Text Available Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  8. The conforming brain and deontological resolve.

    Science.gov (United States)

    Pincus, Melanie; LaViers, Lisa; Prietula, Michael J; Berns, Gregory

    2014-01-01

    Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC) during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  9. Depth-resolved fluorescence of biological tissue

    Science.gov (United States)

    Wu, Yicong; Xi, Peng; Cheung, Tak-Hong; Yim, So Fan; Yu, Mei-Yung; Qu, Jianan Y.

    2005-06-01

    The depth-resolved autofluorescence ofrabbit oral tissue, normal and dysplastic human ectocervical tissue within l20μm depth were investigated utilizing a confocal fluorescence spectroscopy with the excitations at 355nm and 457nm. From the topmost keratinizing layer of oral and ectocervical tissue, strong keratin fluorescence with the spectral characteristics similar to collagen was observed. The fluorescence signal from epithelial tissue between the keratinizing layer and stroma can be well resolved. Furthermore, NADH and FADfluorescence measured from the underlying non-keratinizing epithelial layer were strongly correlated to the tissue pathology. This study demonstrates that the depth-resolved fluorescence spectroscopy can reveal fine structural information on epithelial tissue and potentially provide more accurate diagnostic information for determining tissue pathology.

  10. Imposing resolved turbulence in CFD simulations

    DEFF Research Database (Denmark)

    Gilling, L.; Sørensen, Niels N.

    2011-01-01

    In large‐eddy simulations, the inflow velocity field should contain resolved turbulence. This paper describes and analyzes two methods for imposing resolved turbulence in the interior of the domain in Computational Fluid Dynamics simulations. The intended application of the methods is to impose...... resolved turbulence immediately upstream of the region or structure of interest. Comparing to the alternative of imposing the turbulence at the inlet, there is a large potential to reduce the computational cost of the simulation by reducing the total number of cells. The reduction comes from a lower demand...... of modifying the source terms. None of the two methods can impose synthetic turbulence with good results, but it is shown that by running the turbulence field through a short precursor simulation, very good results are obtained. Copyright © 2011 John Wiley & Sons, Ltd....

  11. Trace gas retrievals from Airborne Compact Atmospheric Mapper (ACAM) observations during the 2011 DISCOVER-AQ flight campaign

    Science.gov (United States)

    Liu, X.; Kowalewski, M. G.; Janz, S. J.; Bhartia, P. K.; Chance, K.; Krotkov, N. A.; Pickering, K. E.; Crawford, J. H.

    2011-12-01

    The DISCOVER-AQ (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality) mission has just finished its first flight campaign in the Baltimore-Washington D.C. area in July 2011. The ACAM, flown on board the NASA UC-12 aircraft, includes two spectrographs covering the spectral region 304-900 nm and a high-definition video camera, and is expected to provide column measurements of several important air quality trace gases and aerosols for the DISCOVER-AQ mission. The quick look results for NO2 have been shown to very useful in capturing the strong spatiotemporal variability of NO2. Preliminary fitting of UV/Visible spectra has shown that ACAM measurements have adequate signal to noise ratio to measure the trace gases O2, NO2, HCHO, and maybe SO2 and CHOCHO, at individual pixel resolution, although a great deal of effort is needed to improve the instrument calibration and derive proper reference spectrum for retrieving absolute trace gas column densities. In this study, we present analysis of ACAM instrument calibration including slit function, wavelength registration, and radiometric calibration for both nadir-viewing and zenith-sky measurements. Based on this analysis, an irradiance reference spectrum at ACAM resolution will be derived from a high-resolution reference spectrum with additional correction to account for instrument calibration. Using the derived reference spectrum and/or the measured zenith sky measurements, we will perform non-linear least squares fitting to investigate the retrievals of slant column densities of these trace gases from ACAM measurements, and also use an optimal estimation based algorithm including full radiative transfer calculations to derive the vertical column densities of these trace gases. The initial results will be compared with available in-situ and ground-based measurements taken during the DISCOVER-AQ campaign.

  12. Earth's Largest Meteorite Impact Craters discovered in South America?

    Science.gov (United States)

    Kellndorfer, J. M.; Schmidt-Falkenberg, H.

    2014-12-01

    Novel analysis of high resolution InSAR-based digital elevation data from the year 2001 Shuttle Radar Topography Mission combined with a recently produced dataset of pan-tropical vegetation height from ALOS-1 SAR and IceSAT/GLAS Lidar estimates led to the quasi-bald-Earth discovery of four sizable near-perfect circle arcs in South America under dense tropical forests ranging in length from 216 km to 441 km. Terrain elevation profiles of cross-sections across the arcs show a distinct vertical rising and falling in elevations of hundreds of meters over a horizontal distance of tens of kilometers. It is hypothesized that these sizable arcs and associated rim-like topographic terrain features are remnants of huge meteorite impact craters with diameters ranging from 770 km to 1,310 km, thus forming potentially the largest known impact carter structures discovered on Earth today. The potential impact crater rim structures are located north of the eastern Amazon River, in the coastal region of Recife and Natal, and in the Brazilian, Bolivian and Paraguayan border region encompassing the Pantanal. Elevation profiles, hillshades and gray-shaded elevation maps were produced to support the geomorphologic analysis. It is also speculated whether in three of the four potential impact craters, central uplift domes or peaks, which are typical for complex impact crater structures can be identified. The worlds largest iron ore mining area of Carajás in Para, Brazil, falls exactly in the center of the largest hypothesized circular impact crater showing topographic elevations similar to the rim structure discovered 655 km to the north-north-west. Based on the topographic/geomorphologic driven hypothesis, geologic exploration of these topographic features is needed to test whether indeed meteorite impact craters could be verified, what the more exact ellipsoidal shapes of the potential impact craters might be, and to determine when during geologic times the impacts would have taken

  13. Angle-Resolved Spectroscopy of Parametric Fluorescence

    CERN Document Server

    Hsu, Feng-kuo

    2013-01-01

    The parametric fluorescence from a nonlinear crystal forms a conical radiation pattern. We measure the angular and spectral distributions of parametric fluorescence in a beta-barium borate crystal pumped by a 405-nm diode laser employing angle-resolved imaging spectroscopy. The experimental angle-resolved spectra and the generation efficiency of parametric down conversion are compared with a plane-wave theoretical analysis. The parametric fluorescence is used as a broadband light source for the calibration of the instrument spectral response function in the wavelength range from 450 to 1000 nm.

  14. Time resolved thermal lens in edible oils

    Science.gov (United States)

    Albuquerque, T. A. S.; Pedreira, P. R. B.; Medina, A. N.; Pereira, J. R. D.; Bento, A. C.; Baesso, M. L.

    2003-01-01

    In this work time resolved thermal lens spectrometry is applied to investigate the optical properties of the following edible oils: soya, sunflower, canola, and corn oils. The experiments were performed at room temperature using the mode mismatched thermal lens configuration. The results showed that when the time resolved procedure is adopted the technique can be applied to investigate the photosensitivity of edible oils. Soya oil presented a stronger photochemical reaction as compared to the other investigated samples. This observation may be relevant for future studies evaluating edible oils storage conditions and also may contribute to a better understanding of the physical and chemical properties of this important foodstuff.

  15. Reverse Universal Resolving Algorithm and inverse driving

    DEFF Research Database (Denmark)

    Pécseli, Thomas

    2012-01-01

    Inverse interpretation is a semantics based, non-standard interpretation of programs. Given a program and a value, an inverse interpreter finds all or one of the inputs, that would yield the given value as output with normal forward evaluation. The Reverse Universal Resolving Algorithm is a new...... variant of the Universal Resolving Algorithm for inverse interpretation. The new variant outperforms the original algorithm in several cases, e.g., when unpacking a list using inverse interpretation of a pack program. It uses inverse driving as its main technique, which has not been described in detail...

  16. 南充市应用生物导弹防治玉米螟效果和效益研究%Control Effect of Bio-guide Wasp Virus Missile on Ostrinia furnacalis and Its Benefits for Maize Production in Nanchong City

    Institute of Scientific and Technical Information of China (English)

    彭昌家; 苟建华; 罗怀海; 白体坤; 丁攀; 冯礼斌; 尹怀中; 龙维国; 杨宇衡; 杨建华; 何海燕

    2016-01-01

    为了推进"绿色植保",减少农药用量及残留和环境污染与防治成本,确保玉米生产、品质和生态环境安全,促进玉米增产增收,采用灯下诱蛾和田间剥查与试验示范相结合等方法,开展生物导弹防治玉米螟效果和效益研究。结果表明,每公顷投放生物导弹30~37对,平均防效78.0%,防治成本139.50~172.50元,比化学农药防治少142.50~168.00元,玉米产量比空白对照区平均高817.8 kg,增产11.0%,增加产值1799.16元,增收节支1941.66~1967.16元。2003~2014年累计示范推广24507.33 hm2,增产2004.21万 kg,新增产值4409.26万元,节省防治费用349.23~411.72万元,增收节支4758.49~4820.98万元,减少农药5%杀虫双大粒剂551.41 t或90%杀虫单使用12.87 t。且生物导弹使用简便,劳动强度小,适于老、弱、妇、幼操作,对人畜和环境安全,节省药械和用水,是有机农业、现代农业、绿色和无公害农产品及IBM绿色防控示范园区防治玉米螟、减少化学农药的理想替代产品。%In order to promote "green plant protection", reduce the administration dosage and residue of pesticides and control cost of environment pol ution, and im-prove maize production, quality and agricultural ecological environment safety. In this study, the control effect and benefit of bio-guide wasp virus missile (BGWVM) on Ostrinia furnacalis in Nanchong City was investigated by using insect light traps and combined method of field investigation and experimental demonstration. According to the results, applying 30-37 pairs of BGWVM per hectare exhibited an average con-trol efficiency of 78.0%, and the control cost was 139.50-172.50 CNY/hm2, which was reduced by 142.50-168.00 CNY/hm2 compared with conventional chemical con-trol. Average maize yield in BGWVM demonstration plot was 817.8 kg/hm2 higher and improved by 11.0% compared with blank control plot. The output value was improved by 1 799

  17. Prasinoxanthin-constaining Prasinophyceae Discovered in Jiaozhou Bay, China

    Institute of Scientific and Technical Information of China (English)

    Zhi-Gang Yu; Chun-Mei Deng; Peng Yao; Yu Zhen; Shu-Ben Qian

    2007-01-01

    The class Prasinophyceae (Chlorophyta) contains some photosynthetic eukaryotlc ultraplankton species characterized by containing prasinoxanthin. The existence and abundance of these organisms can be estimated by the diagnostic pigment. We detected the unique pigments of prasinoxanthin-contalning Prasinophyceae in Jlaozhou Bay, China using high performance liquid chromatography (HPLC). This was the first finding of this kind in Chinese seas. Using the ratio of prasinoxanthin to chlorophyll a, the abundance of prasinoxanthin-containing Prasinophyceae has been calculated. The average contribution of prasinoxanthin-contalning Prasinophyceae to the chlorophyll a pool was 8.5% and 17.0% in May and August 2004 in Jiaozhou Bay, and the maximums were 25.9% and 36.3%. Size fractionated pigment analysis suggested that more than 80% of prasinoxanthin were in the fraction of 2-20 μm.According to the results of pigment and morphological analysis, the possible genera of prasinoxanthin-containing Prasinophyceae and the reasons for causing this high abundant phytoplankton in Jiaozhou Bay were discussed.This kind of phytoplankton can not be discovered in traditional biological investigation, but its contribution to the coastal ecosystem is significant enough to be studied further.

  18. Timing of Five PALFA-Discovered Millisecond Pulsars

    CERN Document Server

    Stovall, K; Bogdanov, S; Brazier, A; Camilo, F; Cardoso, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J S; Ferdman, R; Freire, P C C; Hessels, J W T; Jenet, F; Kaplan, D L; Karako-Argaman, C; Kaspi, V M; Knispel, B; Kotulla, R; Lazarus, P; Lee, K J; van Leeuwen, J; Lynch, R; Lyne, A G; Madsen, E; McLaughlin, M A; Patel, C; Ransom, S M; Scholz, P; Siemens, X; Stairs, I H; Stappers, B W; Swiggum, J; Zhu, W W; Venkataraman, A

    2016-01-01

    We report the discovery and timing results for five millisecond pulsars (MSPs) from the Arecibo PALFA survey: PSRs J1906+0055, J1914+0659, J1933+1726, J1938+2516, and J1957+2516. Timing observations of the 5 pulsars were conducted with the Arecibo and Lovell telescopes for time spans ranging from 1.5 to 3.3 yr. All of the MSPs except one (PSR J1914+0659) are in binary systems with low eccentricities. PSR J1957+2516 is likely a redback pulsar, with a ~0.1 $M_\\odot$ companion and possible eclipses that last ~10% of the orbit. The position of PSR J1957+2516 is also coincident with a NIR source. All 5 MSPs are distant (>3.1 kpc) as determined from their dispersion measures, and none of them show evidence of $\\gamma$-ray pulsations in a search of Fermi Gamma-Ray Space Telescope data. These 5 MSPs bring the total number of MSPs discovered by the PALFA survey to 26 and further demonstrate the power of this survey in finding distant, highly dispersed MSPs deep in the Galactic plane.

  19. Discovering English tense-backshift parameters through discourse

    Directory of Open Access Journals (Sweden)

    Silvana Orel Kos

    2014-12-01

    Full Text Available English grammars and teaching materials often fail to include references to specific discoursal and communicative functions. This facilitates the foreign language acquisition process during which learners acquire basic linguistic skills. The teaching of indirect discourse or so-called reported speech is no exception in this respect: easy-to-learn grammatical rules governing tense-backshift are combined with rather open-ended communicative functions. The CEFR 2011, however, aims at developing the user’s communicative competence, which at its most naturally-occurring level includes the pragmatic-discursive components. The article presents a discourse-oriented approach to indirect discourse teaching and learning, in which the role of the communication mediator, i.e. the indirect discourse producer, is presented as one of the most significant parameters that have been analytically disregarded, yet it provides an identification model for the learner as an active language user. Our approach focuses on further important parameters of indirect discourse, i.e. the discoursal macrotextual type, the focus on the original communicator or the message, the communication mediator’s attitude or involvement, semantic, stylistic and syntactic restrictions. The suggested discourse-oriented approach encourages students to discover “grammatical rules” on their own, which should enable them to develop more internalized and confident language production skills.

  20. Discovering Patterns in Brain Signals Using Decision Trees

    Directory of Open Access Journals (Sweden)

    Narusci S. Bastos

    2016-01-01

    Full Text Available Even with emerging technologies, such as Brain-Computer Interfaces (BCI systems, understanding how our brains work is a very difficult challenge. So we propose to use a data mining technique to help us in this task. As a case of study, we analyzed the brain’s behaviour of blind people and sighted people in a spatial activity. There is a common belief that blind people compensate their lack of vision using the other senses. If an object is given to sighted people and we asked them to identify this object, probably the sense of vision will be the most determinant one. If the same experiment was repeated with blind people, they will have to use other senses to identify the object. In this work, we propose a methodology that uses decision trees (DT to investigate the difference of how the brains of blind people and people with vision react against a spatial problem. We choose the DT algorithm because it can discover patterns in the brain signal, and its presentation is human interpretable. Our results show that using DT to analyze brain signals can help us to understand the brain’s behaviour.

  1. Fast Algorithms for Discovering Sequential Patterns in Massive Datasets

    Directory of Open Access Journals (Sweden)

    S. Dharani

    2011-01-01

    Full Text Available Problem statement: Sequential pattern mining is one of the specific data mining tasks, particularly from retail data. The task is to discover all sequential patterns with a user-specified minimum support, where support of a pattern is the number of data-sequences that contain the pattern. Approach: To find a sequence patterns variety of algorithm like AprioriAll and Generalized Sequential Patterns (GSP were there. We present fast and efficient algorithms called AprioriAllSID and GSPSID for mining sequential patterns that were fundamentally different from known algorithms. Results: The proposed algorithm had been implemented and compared with AprioriAll and Generalized Sequential Patterns (GSP. Its performance was studied on an experimental basis. We combined the AprioriAllSID algorithm with AprioriAll algorithm into a Hybrid algorithm, called AprioriAll Hybrid. Conclusion: Implementation shows that the execution time of the algorithm to find sequential pattern depends on total no of candidates generated at each level and the time taken to scan the database. Our performance study shows that the proposed algorithms have an excellent performance over the best existing algorithms.

  2. SUBic: A Scalable Unsupervised Framework for Discovering High Quality Biclusters

    Institute of Scientific and Technical Information of China (English)

    Jooil Lee; Yanhua Jin; Won Suk Lee

    2013-01-01

    A biclustering algorithm extends conventional clustering techniques to extract all of the meaningful subgroups of genes and conditions in the expression matrix of a microarray dataset.However,such algorithms are very sensitive to input parameters and show poor scalability.This paper proposes a scalable unsupervised biclustering framework,SUBic,to find high quality constant-row biclusters in an expression matrix effectively.A one-dimensional clustering algorithm is proposed to partition the attributes,that is,columns of an expression matrix into disjoint groups based on the similarity of expression values.These groups form a set of short transactions and are used to discover a set of frequent itemsets each of which corresponds to a bicluster.However,a bicluster may include any attribute whose expression value is not similar enough to others,so a bicluster refinement is used to enhance the quality of a bicluster by removing those attributes based on its distribution of expression values.The performance of the proposed method is comparatively analyzed through a series of experiments on synthetic and real datasets.

  3. Discovering Patterns in Brain Signals Using Decision Trees

    Science.gov (United States)

    2016-01-01

    Even with emerging technologies, such as Brain-Computer Interfaces (BCI) systems, understanding how our brains work is a very difficult challenge. So we propose to use a data mining technique to help us in this task. As a case of study, we analyzed the brain's behaviour of blind people and sighted people in a spatial activity. There is a common belief that blind people compensate their lack of vision using the other senses. If an object is given to sighted people and we asked them to identify this object, probably the sense of vision will be the most determinant one. If the same experiment was repeated with blind people, they will have to use other senses to identify the object. In this work, we propose a methodology that uses decision trees (DT) to investigate the difference of how the brains of blind people and people with vision react against a spatial problem. We choose the DT algorithm because it can discover patterns in the brain signal, and its presentation is human interpretable. Our results show that using DT to analyze brain signals can help us to understand the brain's behaviour. PMID:27688746

  4. Discovering large network motifs from a complex biological network

    Energy Technology Data Exchange (ETDEWEB)

    Terada, Aika; Sese, Jun, E-mail: terada@sel.is.ocha.ac.j, E-mail: sesejun@is.ocha.ac.j [Department of Computer Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610 (Japan)

    2009-12-01

    Graph structures representing relationships between entries have been studied in statistical analysis, and the results of these studies have been applied to biological networks, whose nodes and edges represent proteins and the relationships between them, respectively. Most of the studies have focused on only graph structures such as scale-free properties and cliques, but the relationships between nodes are also important features since most of the proteins perform their functions by connecting to other proteins. In order to determine such relationships, the problem of network motif discovery has been addressed; network motifs are frequently appearing graph structures in a given graph. However, the methods for network motif discovery are highly restrictive for the application to biological network because they can only be used to find small network motifs or they do not consider noise and uncertainty in observations. In this study, we introduce a new index to measure network motifs called AR index and develop a novel algorithm called ARIANA for finding large motifs even when the network has noise. Experiments using a synthetic network verify that our method can find better network motifs than an existing algorithm. By applying ARIANA to a real complex biological network, we find network motifs associated with regulations of start time of cell functions and generation of cell energies and discover that the cell cycle proteins can be categorized into two different groups.

  5. Discovering market basket patterns using hierarchical association rules

    Directory of Open Access Journals (Sweden)

    Marijana Zekić-Sušac

    2015-10-01

    Full Text Available Association rules are a data mining method for discovering patterns of frequent item sets, such as products in a store that are frequently purchased at the same time by a customer (market basket analysis. A number of interestingness measures for association rules have been developed to date, but research has shown that there a dominant measure does not exist. Authors have mostly used objective measures, whereas subjective measures have rarely been investigated. This paper aims to combine objective measures such as support, confidence and lift with a subjective approach based on human expert selection in order to extract interesting rules from a real dataset collected from a large Croatian retail chain. Hierarchical association rules were used to enhance the efficiency of the extraction rule. The results show that rules that are more interesting were extracted using the hierarchical method, and that a hybrid approach of combining objective and subjective measures succeeds in extracting certain unexpected and actionable rules. The research can be useful for retail and marketing managers in planning marketing strategies, as well as for researchers investigating this field.

  6. Timing of 29 Pulsars Discovered in the PALFA Survey

    CERN Document Server

    Lyne, A G; Bogdanov, S; Ferdman, R; Freire, P C C; Kaspi, V M; Knispel, B; Lynch, R; Allen, B; Brazier, A; Camilo, F; Cardoso, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J S; Hessels, J W T; Jenet, F A; Lazarus, P; van Leeuwen, J; Lorimer, D R; Madsen, E; McKee, J; McLaughlin, M A; Parent, E; Patel, C; Ransom, S M; Scholz, P; Seymour, A; Siemens, X; Spitler, L G; Stairs, I H; Stovall, K; Swiggum, J; Wharton, R S; Zhu, W W

    2016-01-01

    We report on the discovery and timing observations of 29 distant long-period pulsars discovered in the ongoing Arecibo PALFA pulsar survey. Following discovery with the Arecibo Telescope, confirmation and timing observations of these pulsars over several years at Jodrell Bank Observatory have yielded high-precision positions and measurements of rotation and radiation properties. We have used multi-frequency data to measure the interstellar scattering properties of some of these pulsars. Most of the pulsars have properties that mirror those of the previously known pulsar population, although four show some notable characteristics. PSRs J1907+0631 and J1925+1720 are young and are associated with supernova remnants or plerionic nebulae: J1907+0631 lies close to the center of SNR G40.5-0.5, while J1925+1720 is coincident with a high-energy Fermi gamma-ray source. One pulsar, J1932+1500, is in a surprisingly eccentric, 199-day binary orbit with a companion having a minimum mass of 0.33 solar masses. Several of the...

  7. Discovering High-Quality Threaded Discussions in Online Forums

    Institute of Scientific and Technical Information of China (English)

    Jung-Tae Lee; Min-Chul Yang; Hae-Chang Rim

    2014-01-01

    Archives of threaded discussions generated by users in online forums and discussion boards contain valuable knowledge on various topics. However, not all threads are useful because of deliberate abuses, such as trolling and flaming, that are commonly observed in online conversations. The existence of various users with different levels of expertise also makes it difficult to assume that every discussion thread stored online contains high-quality contents. Although finding high-quality threads automatically can help both users and search engines sift through a huge amount of thread archives and make use of these potentially useful resources effectively, no previous work to our knowledge has performed a study on such task. In this paper, we propose an automatic method for distinguishing high-quality threads from low-quality ones in online discussion sites. We first suggest four different artificial measures for inducing overall quality of a thread based on ratings of its posts. We then propose two tasks involving prediction of thread quality without using post rating information. We adopt a popular machine learning framework to solve the two prediction tasks. Experimental results on a real world forum archive demonstrate that our method can significantly improve the prediction performance across all four measures of thread quality on both tasks. We also compare how different types of features derived from various aspects of threads contribute to the overall performance and investigate key features that play a crucial role in discovering high-quality threads in online discussion sites.

  8. Cellular metabolic network analysis: discovering important reactions in Treponema pallidum.

    Science.gov (United States)

    Chen, Xueying; Zhao, Min; Qu, Hong

    2015-01-01

    T. pallidum, the syphilis-causing pathogen, performs very differently in metabolism compared with other bacterial pathogens. The desire for safe and effective vaccine of syphilis requests identification of important steps in T. pallidum's metabolism. Here, we apply Flux Balance Analysis to represent the reactions quantitatively. Thus, it is possible to cluster all reactions in T. pallidum. By calculating minimal cut sets and analyzing topological structure for the metabolic network of T. pallidum, critical reactions are identified. As a comparison, we also apply the analytical approaches to the metabolic network of H. pylori to find coregulated drug targets and unique drug targets for different microorganisms. Based on the clustering results, all reactions are further classified into various roles. Therefore, the general picture of their metabolic network is obtained and two types of reactions, both of which are involved in nucleic acid metabolism, are found to be essential for T. pallidum. It is also discovered that both hubs of reactions and the isolated reactions in purine and pyrimidine metabolisms play important roles in T. pallidum. These reactions could be potential drug targets for treating syphilis.

  9. Unified Photo Enhancement by Discovering Aesthetic Communities From Flickr.

    Science.gov (United States)

    Hong, Richang; Zhang, Luming; Tao, Dacheng

    2016-03-01

    Photo enhancement refers to the process of increasing the aesthetic appeal of a photo, such as changing the photo aspect ratio and spatial recomposition. It is a widely used technique in the printing industry, graphic design, and cinematography. In this paper, we propose a unified and socially aware photo enhancement framework which can leverage the experience of photographers with various aesthetic topics (e.g., portrait and landscape). We focus on photos from the image hosting site Flickr, which has 87 million users and to which more than 3.5 million photos are uploaded daily. First, a tagwise regularized topic model is proposed to describe the aesthetic topic of each Flickr user, and coherent and interpretable topics are discovered by leveraging both the visual features and tags of photos. Next, a graph is constructed to describe the similarities in aesthetic topics between the users. Noticeably, densely connected users have similar aesthetic topics, which are categorized into different communities by a dense subgraph mining algorithm. Finally, a probabilistic model is exploited to enhance the aesthetic attractiveness of a test photo by leveraging the photographic experiences of Flickr users from the corresponding communities of that photo. Paired-comparison-based user studies show that our method performs competitively on photo retargeting and recomposition. Moreover, our approach accurately detects aesthetic communities in a photo set crawled from nearly 100000 Flickr users.

  10. Oxygen and carbon discovered in exoplanet atmosphere `blow-off'

    Science.gov (United States)

    2004-02-01

    Oxygen and carbon discovered in exoplanet atmosphere ‘blow-off’ hi-res Size hi-res: 1096 kb Credits: ESA/Alfred Vidal-Madjar (Institut d’Astrophysique de Paris, CNRS, France) Oxygen and carbon discovered in exoplanet atmosphere ‘blow-off’ This artist’s impression shows an extended ellipsoidal envelope - the shape of a rugby-ball - of oxygen and carbon discovered around the well-known extrasolar planet HD 209458b. An international team of astronomers led by Alfred Vidal-Madjar (Institut d’Astrophysique de Paris, CNRS, France) observed the first signs of oxygen and carbon in the atmosphere of a planet beyond our Solar System for the first time using the NASA/ESA Hubble Space Telescope. The atoms of carbon and oxygen are swept up from the lower atmosphere with the flow of escaping atmospheric atomic hydrogen - like dust in a supersonic whirlwind - in a process called atmospheric ‘blow off’. Oxygen and carbon have been detected in the atmosphere of a planet beyond our Solar System for the first time. Scientists using the NASA/ESA Hubble Space Telescope have observed the famous extrasolar planet HD 209458b passing in front of its parent star, and found oxygen and carbon surrounding the planet in an extended ellipsoidal envelope - the shape of a rugby-ball. These atoms are swept up from the lower atmosphere with the flow of the escaping atmospheric atomic hydrogen, like dust in a supersonic whirlwind. The team led by Alfred Vidal-Madjar (Institut d’Astrophysique de Paris, CNRS, France) reports this discovery in a forthcoming issue of Astrophysical Journal Letters. The planet, called HD 209458b, may sound familiar. It is already an extrasolar planet with an astounding list of firsts: the first extrasolar planet discovered transiting its sun, the first with an atmosphere, the first observed to have an evaporating hydrogen atmosphere (in 2003 by the same team of scientists) and now the first to have an atmosphere containing oxygen and carbon. Furthermore

  11. Decision Tree Approach to Discovering Fraud in Leasing Agreements

    Directory of Open Access Journals (Sweden)

    Horvat Ivan

    2014-09-01

    Full Text Available Background: Fraud attempts create large losses for financing subjects in modern economies. At the same time, leasing agreements have become more and more popular as a means of financing objects such as machinery and vehicles, but are more vulnerable to fraud attempts. Objectives: The goal of the paper is to estimate the usability of the data mining approach in discovering fraud in leasing agreements. Methods/Approach: Real-world data from one Croatian leasing firm was used for creating tow models for fraud detection in leasing. The decision tree method was used for creating a classification model, and the CHAID algorithm was deployed. Results: The decision tree model has indicated that the object of the leasing agreement had the strongest impact on the probability of fraud. Conclusions: In order to enhance the probability of the developed model, it would be necessary to develop software that would enable automated, quick and transparent retrieval of data from the system, processing according to the rules and displaying the results in multiple categories.

  12. Discovering Psychological Principles by Mining Naturally Occurring Data Sets.

    Science.gov (United States)

    Goldstone, Robert L; Lupyan, Gary

    2016-07-01

    The very expertise with which psychologists wield their tools for achieving laboratory control may have had the unwelcome effect of blinding psychologists to the possibilities of discovering principles of behavior without conducting experiments. When creatively interrogated, a diverse range of large, real-world data sets provides powerful diagnostic tools for revealing principles of human judgment, perception, categorization, decision-making, language use, inference, problem solving, and representation. Examples of these data sets include patterns of website links, dictionaries, logs of group interactions, collections of images and image tags, text corpora, history of financial transactions, trends in twitter tag usage and propagation, patents, consumer product sales, performance in high-stakes sporting events, dialect maps, and scientific citations. The goal of this issue is to present some exemplary case studies of mining naturally existing data sets to reveal important principles and phenomena in cognitive science, and to discuss some of the underlying issues involved with conducting traditional experiments, analyses of naturally occurring data, computational modeling, and the synthesis of all three methods.

  13. New Star Clusters Discovered in the GLIMPSE Survey

    Science.gov (United States)

    Mercer, E. P.; Clemens, D. P.; Meade, M. R.; Babler, B. L.; Indebetouw, R.; Whitney, B. A.; Watson, C.; Wolfire, M. G.; Wolff, M. J.; Bania, T. M.; Benjamin, R. A.; Cohen, M.; Dickey, J. M.; Jackson, J. M.; Kobulnicky, H. A.; Mathis, J. S.; Stauffer, J. R.; Stolovy, S. R.; Uzpen, B.; Churchwell, E. B.

    2005-12-01

    A systematic and automated search of the extensive GLIMPSE mid-infrared survey data of the inner Galaxy was carried out to uncover new star clusters. This search has yielded 59 new clusters. Using our automated search algorithm, these clusters were identified as significant localized overdensities in the GLIMPSE point-source catalog (GLMC) and archive (GLMA). Subsequent visual inspection of the GLIMPSE image mosaics confirmed the existence of these clusters plus an additional 33 heavily embedded clusters missed by our detection algorithm, for a total of 92 newly discovered clusters. These previously uncataloged clusters range in type from heavily embedded to fully exposed clusters. More than half of the clusters have memberships exceeding 35 stars, and nearly all the clusters have diameters of 3' or less. The Galactic latitude distribution of the clusters reveals that the majority are concentrated toward the Galactic midplane. There is an asymmetry in the number of clusters located above and below the midplane, with more clusters detected below the midplane. We also observe an asymmetry in the number of clusters detected in the northern and southern halves of the Galaxy, with more than twice as many clusters detected in the south.

  14. Two Radio Supernova Remnants Discovered in the Outer Galaxy

    CERN Document Server

    Foster, Tyler; Reich, Wolfgang; Kothes, Roland; West, Jennifer; 10.1051/0004-6361/201220362

    2013-01-01

    We report on the discovery of two supernova remnants (SNRs) designated G152.4-2.1 and G190.9-2.2, using Canadian Galactic Plane Survey data. The aims of this paper are, first, to present evidence that favours the classification of both sources as SNRs, and, second, to describe basic parameters (integrated flux density, spectrum, and polarization) as well as properties (morphology, line-of-sight velocity, distance and physical size) to facilitate and motivate future observations. Spectral and polarization parameters are derived from multiwavelength data from existing radio surveys carried out at wavelengths between 6 and 92cm. In particular for the source G152.4-2.1 we also use new observations at 11cm done with the Effelsberg 100m telescope. The interstellar medium around the discovered sources is analyzed using 1-arcminute line data from neutral hydrogen (HI) and 45-arcsecond 12CO(J=1-0). G152.4-2.1 is a barrel shaped SNR with two opposed radio-bright polarized flanks on the North and South. The remnant, whi...

  15. Discovering Topology of MultiSubnet LAN using MIB

    Directory of Open Access Journals (Sweden)

    Sapna Harishankar

    2012-08-01

    Full Text Available Today, Ethernet is the dominant local area network(LAN technology. These networks, typically, comprise large number of elements from different vendors. This raises considerable difficulties in performing network management tasks, such as resource management and root cause analysis, which are practically impossible without an up-to-date knowledge of the physical network topology. Given the dynamic nature of today's LANs, keeping track of topology information manually is a daunting (if not impossible task. Therefore, it is essential to develop practical schemes for automatic inference of the physical topology of Ethernet networks. In this paper, we propose a simple and efficient algorithmic solution for discovering the physical topology of large, heterogeneous Ethernet LANs that may include multiple subnets as well as uncooperative network elements, like hubs. Our scheme utilizes only generic MIB information and does not required any hardware or software modification of the underlying network elements. By rigorous analysis, we prove that our method correctly infers the network topology and has low communication and computational overheads.

  16. GRB 050505: A high redshift burst discovered by Swift

    CERN Document Server

    Hurkett, C P; Page, K L; Rol, E; Goad, M R; O'Brien, P T; Beardmore, A; Godet, O; Burrows, D N; Tanvir, N R; Levan, A; Zhang, B; Malesani, D; Hill, J E; Kennea, J A; Chapman, R; La Parola, V; Perri, M; Romano, P; Gehrels, R S N

    2006-01-01

    We report the discovery and subsequent multi-wavelength afterglow behaviour of the high redshift (z = 4.27) Gamma Ray Burst GRB 050505. This burst is the third most distant burst, measured by spectroscopic redshift, discovered after GRB 000131 (z = 4.50) and GRB 050904 (z = 6.29). GRB 050505 is a long GRB with a multipeaked gamma-ray light curve, with a duration of T_90 = 63+/-2 s and an inferred isotropic release in gamma-rays of ~4.44 x 10^53 ergs in the 1-10^4 keV rest frame energy range. The Swift X-Ray Telescope followed the afterglow for 14 days, detecting two breaks in the light curve at 7.4(+/-1.5) ks and 58.0 (+9.9/-15.4) ks after the burst trigger. The power law decay slopes before, between and after these breaks were 0.25 (+0.16/-0.17), 1.17 (+0.08/-0.09) and 1.97 (+0.27/-0.28) respectively. The light curve can also be fit with a `smoothly broken' power law model with a break observed at ~ T+18.5 ks, with decay slopes of ~0.4 and ~1.8 before and after the break respectively. The X-ray afterglow sho...

  17. Inner solar system material discovered in the Oort cloud.

    Science.gov (United States)

    Meech, Karen J; Yang, Bin; Kleyna, Jan; Hainaut, Olivier R; Berdyugina, Svetlana; Keane, Jacqueline V; Micheli, Marco; Morbidelli, Alessandro; Wainscoat, Richard J

    2016-04-01

    We have observed C/2014 S3 (PANSTARRS), a recently discovered object on a cometary orbit coming from the Oort cloud that is physically similar to an inner main belt rocky S-type asteroid. Recent dynamical models successfully reproduce the key characteristics of our current solar system; some of these models require significant migration of the giant planets, whereas others do not. These models provide different predictions on the presence of rocky material expelled from the inner solar system in the Oort cloud. C/2014 S3 could be the key to verifying these predictions of the migration-based dynamical models. Furthermore, this object displays a very faint, weak level of comet-like activity, five to six orders of magnitude less than that of typical ice-rich comets on similar Orbits coming from the Oort cloud. For the nearly tailless appearance, we are calling C/2014 S3 a Manx object. Various arguments convince us that this activity is produced by sublimation of volatile ice, that is, normal cometary activity. The activity implies that C/2014 S3 has retained a tiny fraction of the water that is expected to be present at its formation distance in the inner solar system. We may be looking at fresh inner solar system Earth-forming material that was ejected from the inner solar system and preserved for billions of years in the Oort cloud.

  18. Gamma ray spectroscopy with PPM resolving power

    CERN Document Server

    Börner, H; Mutti, P

    2002-01-01

    Applications of gamma-ray spectroscopy with ppm resolving power are presented. The extraordinary resolution allows via the Gamma Ray Induced Doppler broadening (GRID) technique to determine lifetimes of excited nuclear levels. This has contributed to important nuclear structure information. We report on the current status of the technique

  19. Inverse Computation and the Universal Resolving Algorithm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We survey fundamental concepts for inverse programming and thenpresent the Uni v ersal Resolving Algorithm, an algorithm for inverse computation in a first-orde r , functional programming language. We discuss the key concepts of the algorithm, including a three-step approach based on the notion of a perfect process tree, and demonstrate our implementation with several examples of inverse computation.

  20. The resolved stellar population of Leo A

    NARCIS (Netherlands)

    Tolstoy, E

    1996-01-01

    New observations of the resolved stellar population of the extremely metal-poor Magellanic dwarf irregular galaxy Leo A in Thuan-Gunn r, g, i, and narrowband Ha filters are presented. Using the recent Cepheid variable star distance determination to Leo A by Hoessel et al., we are able to create an a

  1. Resolving deconvolution ambiguity in gene alternative splicing

    Directory of Open Access Journals (Sweden)

    Hubbell Earl

    2009-08-01

    Full Text Available Abstract Background For many gene structures it is impossible to resolve intensity data uniquely to establish abundances of splice variants. This was empirically noted by Wang et al. in which it was called a "degeneracy problem". The ambiguity results from an ill-posed problem where additional information is needed in order to obtain an unique answer in splice variant deconvolution. Results In this paper, we analyze the situations under which the problem occurs and perform a rigorous mathematical study which gives necessary and sufficient conditions on how many and what type of constraints are needed to resolve all ambiguity. This analysis is generally applicable to matrix models of splice variants. We explore the proposal that probe sequence information may provide sufficient additional constraints to resolve real-world instances. However, probe behavior cannot be predicted with sufficient accuracy by any existing probe sequence model, and so we present a Bayesian framework for estimating variant abundances by incorporating the prediction uncertainty from the micro-model of probe responsiveness into the macro-model of probe intensities. Conclusion The matrix analysis of constraints provides a tool for detecting real-world instances in which additional constraints may be necessary to resolve splice variants. While purely mathematical constraints can be stated without error, real-world constraints may themselves be poorly resolved. Our Bayesian framework provides a generic solution to the problem of uniquely estimating transcript abundances given additional constraints that themselves may be uncertain, such as regression fit to probe sequence models. We demonstrate the efficacy of it by extensive simulations as well as various biological data.

  2. Talkoot Portals: Discover, Tag, Share, and Reuse Collaborative Science Workflows

    Science.gov (United States)

    Wilson, B. D.; Ramachandran, R.; Lynnes, C.

    2009-05-01

    A small but growing number of scientists are beginning to harness Web 2.0 technologies, such as wikis, blogs, and social tagging, as a transformative way of doing science. These technologies provide researchers easy mechanisms to critique, suggest and share ideas, data and algorithms. At the same time, large suites of algorithms for science analysis are being made available as remotely-invokable Web Services, which can be chained together to create analysis workflows. This provides the research community an unprecedented opportunity to collaborate by sharing their workflows with one another, reproducing and analyzing research results, and leveraging colleagues' expertise to expedite the process of scientific discovery. However, wikis and similar technologies are limited to text, static images and hyperlinks, providing little support for collaborative data analysis. A team of information technology and Earth science researchers from multiple institutions have come together to improve community collaboration in science analysis by developing a customizable "software appliance" to build collaborative portals for Earth Science services and analysis workflows. The critical requirement is that researchers (not just information technologists) be able to build collaborative sites around service workflows within a few hours. We envision online communities coming together, much like Finnish "talkoot" (a barn raising), to build a shared research space. Talkoot extends a freely available, open source content management framework with a series of modules specific to Earth Science for registering, creating, managing, discovering, tagging and sharing Earth Science web services and workflows for science data processing, analysis and visualization. Users will be able to author a "science story" in shareable web notebooks, including plots or animations, backed up by an executable workflow that directly reproduces the science analysis. New services and workflows of interest will be

  3. Discovering the Role of Grain Boundary Complexions in Materials

    Energy Technology Data Exchange (ETDEWEB)

    Harmer, Martin P. [Lehigh Univ., Bethlehem, PA (United States)

    2015-03-19

    in a range of materials systems, and to characterize their structures, range of stability and selected physical properties. First, an Au-based bilayer interfacial phase was discovered at a bicrystal boundary in the Si-Au system. This bilayer transitioned abruptly to an intrinsic (“clean”) grain boundary phase, suggesting first-order phase behavior. This study represents the discovery of grain boundary complexions in a completely new system, i.e., a semiconductor-metal system, giving further support to the expectation that grain boundary complexions are a general phenomenon not limited to any particular class of materials. The TiO2-CuO system exhibited four grain boundary interfacial phases: a monolayer, disordered bilayer, disordered trilayer, and non-wetting nanoscale amorphous drop (which likely resulted from dewetting of a nanoscale IGF). SiO2 contamination was discovered in the TiO2-CuO samples, and we hypothesize that this impurity may have caused an “order-disorder” transition to occur. In other words, we expect that pure TiO2-CuO may have a higher tendency to exhibit ordered bilayer and trilayer complexions, which may also exhibit a well-defined order-disorder transition temperature. In this effort we have also identified unique complexion transitions in yttria and strontium titanate.

  4. Discovering Exoplanets with Microlensing: Transition to the Next Generation

    Science.gov (United States)

    Gould, Andrew

    We propose to continue our successful program of planet discovery using the gravitaional microlensing technique. Our work will specifically focus on so-called "high- magnification events", which are exceptionally sensitive to planets, and which allow us to extract exceptionally detailed information about each planetary system. These results will be of high scientific interest in their own right, but will also play a key role in the transition to "next-generation" surveys that will discover many times more planets in "low-magnification events". We will continue to operate and build our network of approximately 30 amateur+professional astronomers (about half each) on 6 continents plus Oceania, which enables the 24 hour coverage that is crucial to extracting planetary science from microlensing events. In particular, by engaging the amateurs at a high scientific level, we will both improve the quantity and quality of amateur data and utilize their role as a "transmission belt" to the broader public. Over the past few years, high-mag events have enabled the first detection of a Jupiter- Saturn analog system, the first census of ice and gas giants beyond the snow line, the recognition that "cold Neptunes" are extremely common, and the detection of 3 very massive, super-Jupiter planets orbiting M dwarfs (which may challenge the standard "core-accretion" paradigm). Analysis of these events has also led to key theoretical insights, including the fact that planet orbital motion can be detected in microlensing events and that careful effort is required to disentangle this from "parallax effects" (due to the Earth's own orbital motion). The direct impact of our proposed work will be to increase the still small statistics of high-mag planet detections (due to the intrinsic rarity of high-mag events) and to exploit the sensitivity of these events to higher-order effects (including parallax, planet orbital motion, and multiple planets) to gain deeper knowledge of detected systems

  5. The Spy VI child: a newly discovered Neandertal infant.

    Science.gov (United States)

    Crevecoeur, Isabelle; Bayle, Priscilla; Rougier, Hélène; Maureille, Bruno; Higham, Thomas; van der Plicht, Johannes; De Clerck, Nora; Semal, Patrick

    2010-12-01

    Spy cave (Jemeppe-sur-Sambre, Belgium) is reputed for the two adult Neandertal individuals discovered in situ in 1886. Recent reassessment of the Spy collections has allowed direct radiocarbon dating of these individuals. The sorting of all of the faunal collections has also led to the discovery of the remains of a Neandertal child, Spy VI. This individual is represented by two mandibular corpus fragments. The left fragment is the most complete and both sides preserve the mental foramen. Four deciduous teeth are associated with these mandibular remains: three incisors and one canine. The lower left canine (Spy 645a) conjoins with the corresponding alveolar socket in the left part of the mandible. Following extant standards, the developmental stage of the preserved teeth indicate an age at death of about one and a half years. In addition to performing a classical morphometric comparative study of the mandible and teeth, we have evaluated the dental tissue proportions using high-resolution microtomographic techniques. Our results show that Spy VI generally falls within the Neandertal range of variation. However, this specimen also exhibits particular traits, notably in the dental internal structural organization, which reveals that variation in the immature Neandertal variation is larger than what was variation currently represented by the available fossil record. These observations demonstrate the need for investigating the frequency and expression of immature Neandertal traits in fossil anterior teeth, as well as their temporal and geographic variation. Direct radiocarbon dating of the Spy VI specimen has been conducted in two different laboratories. The results of Spy VI confirm the age previously determined for the two adults, making the Spy Neandertal remains the youngest ever directly dated in northwest Europe.

  6. An integrated framework for discovering digital library collections

    Institute of Scientific and Technical Information of China (English)

    CALHOUN Karen

    2005-01-01

    Information seekers are generally on their own to discover and use a research library's growing array of digital collections, and coordination of these collections' development and maintenance is often not optimal. The frequent lack of a conscious design for how collections fit together is of equal concern because it means that research libraries are not making the most of the substantial investments they are making in digital initiatives. This paper proposes a framework for a research library's digital collections that offers integrated discovery and a set of best practices to underpin collection building, federated access, and sustainability. The framework's purpose is to give information seekers a powerful and easy way to search across existing and future collections and to retrieve integrated sets of results. The paper and its recommendations are based upon research undertaken by the author and a team of librarians and technologists at Cornell University Library. The team conducted structured interviews of forty-five library staff members involved in digital collection building at Cornell, studied an inventory of the library's more than fifty digital collections, and evaluated seven existing Open Archives Initiative (OAI) and federated search production or prototype systems. The author will discuss herteam's research and the rationale for their recommendations to: present a cohesive view of the library's digital collections for both browsing and searching at the object level; take a programmatic (rather than project-based)approach to digital collection building; require that all new digital collections conform to library-developed and agreed-upon OAI best practices for data providers; and implement organizational structures to sustain the library's digital collections over the long term.

  7. Serum irisin levels and thyroid function--newly discovered association.

    Science.gov (United States)

    Ruchala, Marek; Zybek, Ariadna; Szczepanek-Parulska, Ewelina

    2014-10-01

    Irisin is a newly discovered adipo-myokin, which is reported to have a significant influence on the body metabolism and thermogenesis. Other influencing factors on metabolic state are thyroid hormones, which increase heat production and control the energy balance. Due to numerous similarities in action it seems imperative to explore these substances' potential mutual influence on the body. The aim of the study is to provide the first ever, according to our knowledge, evaluation of serum irisin concentrations in patients with thyroid dysfunction and its correlation with creatine kinase (CK) levels - a serum marker of muscle damage. The studied group consisted of 20 patients with newly diagnosed thyroid disorder - hyperthyroidism or hypothyroidism. Venous blood samples were analyzed for irisin, thyrotropin (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and CK serum concentrations. Patients' body mass index (BMI), body weight and muscle mass were evaluated using bioelectrical impedance analysis (BIA). Median serum irisin levels were lower in hypothyroid (117.30ng/ml) than hyperthyroid (161.95ng/ml) patients with a borderline statistical significance (p=0.0726). The negative correlation between irisin and TSH levels was demonstrated (r=-0.4924, p=0.0230), as well as the positive correlation between irisin and FT4 levels (r=0.4833, p=0.0360). The CK level was negatively correlated with irisin, FT4 and FT3 concentrations (r=-0.7272, p=0.0140; r=-0.9636, p=<0.0001; r=-0.8838, p=0.0007, respectively). The study demonstrates that irisin concentrations may vary according to the thyrometabolic state, which potentially could be related to the degree of muscle damage.

  8. Discovering discovery patterns with Predication-based Semantic Indexing.

    Science.gov (United States)

    Cohen, Trevor; Widdows, Dominic; Schvaneveldt, Roger W; Davies, Peter; Rindflesch, Thomas C

    2012-12-01

    In this paper we utilize methods of hyperdimensional computing to mediate the identification of therapeutically useful connections for the purpose of literature-based discovery. Our approach, named Predication-based Semantic Indexing, is utilized to identify empirically sequences of relationships known as "discovery patterns", such as "drug x INHIBITS substance y, substance y CAUSES disease z" that link pharmaceutical substances to diseases they are known to treat. These sequences are derived from semantic predications extracted from the biomedical literature by the SemRep system, and subsequently utilized to direct the search for known treatments for a held out set of diseases. Rapid and efficient inference is accomplished through the application of geometric operators in PSI space, allowing for both the derivation of discovery patterns from a large set of known TREATS relationships, and the application of these discovered patterns to constrain search for therapeutic relationships at scale. Our results include the rediscovery of discovery patterns that have been constructed manually by other authors in previous research, as well as the discovery of a set of previously unrecognized patterns. The application of these patterns to direct search through PSI space results in better recovery of therapeutic relationships than is accomplished with models based on distributional statistics alone. These results demonstrate the utility of efficient approximate inference in geometric space as a means to identify therapeutic relationships, suggesting a role of these methods in drug repurposing efforts. In addition, the results provide strong support for the utility of the discovery pattern approach pioneered by Hristovski and his colleagues.

  9. Encoded expansion: an efficient algorithm to discover identical string motifs.

    Directory of Open Access Journals (Sweden)

    Aqil M Azmi

    Full Text Available A major task in computational biology is the discovery of short recurring string patterns known as motifs. Most of the schemes to discover motifs are either stochastic or combinatorial in nature. Stochastic approaches do not guarantee finding the correct motifs, while the combinatorial schemes tend to have an exponential time complexity with respect to motif length. To alleviate the cost, the combinatorial approach exploits dynamic data structures such as trees or graphs. Recently (Karci (2009 Efficient automatic exact motif discovery algorithms for biological sequences, Expert Systems with Applications 36:7952-7963 devised a deterministic algorithm that finds all the identical copies of string motifs of all sizes [Formula: see text] in theoretical time complexity of [Formula: see text] and a space complexity of [Formula: see text] where [Formula: see text] is the length of the input sequence and [Formula: see text] is the length of the longest possible string motif. In this paper, we present a significant improvement on Karci's original algorithm. The algorithm that we propose reports all identical string motifs of sizes [Formula: see text] that occur at least [Formula: see text] times. Our algorithm starts with string motifs of size 2, and at each iteration it expands the candidate string motifs by one symbol throwing out those that occur less than [Formula: see text] times in the entire input sequence. We use a simple array and data encoding to achieve theoretical worst-case time complexity of [Formula: see text] and a space complexity of [Formula: see text] Encoding of the substrings can speed up the process of comparison between string motifs. Experimental results on random and real biological sequences confirm that our algorithm has indeed a linear time complexity and it is more scalable in terms of sequence length than the existing algorithms.

  10. High-School Student Discovers Strange Astronomical Object

    Science.gov (United States)

    2009-09-01

    A West Virginia high-school student analyzing data from a giant radio telescope has discovered a new astronomical object -- a strange type of neutron star called a rotating radio transient. Lucas Bolyard, a sophomore at South Harrison High School in Clarksburg, WV, made the discovery while participating in a project in which students are trained to scrutinize data from the National Science Foundation's giant Robert C. Byrd Green The project, called the Pulsar Search Collaboratory (PSC), is a joint project of the National Radio Astronomy Observatory (NRAO) and West Virginia University (WVU), funded by a grant from the National Science Foundation. Bolyard made the discovery in March, after he already had studied more than 2,000 data plots from the GBT and found nothing. "I was home on a weekend and had nothing to do, so I decided to look at some more plots from the GBT," he said. "I saw a plot with a pulse, but there was a lot of radio interference, too. The pulse almost got dismissed as interference," he added. Nonetheless, he reported it, and it went on a list of candidates for West Virginia University astronomers Maura McLaughlin and Duncan Lorimer to re-examine, scheduling new observations of the region of sky from which the pulse came. Disappointingly, the follow-up observations showed nothing, indicating that the object was not a normal pulsar. However, the astronomers explained to Bolyard that his pulse still might have come from a rotating radio transient. Confirmation didn't come until July. Bolyard was at the NRAO's Green Bank Observatory with fellow PSC students. The night before, the group had been observing with the GBT in the wee hours, and all were very tired. Then Lorimer showed Bolyard a new plot of his pulse, reprocessed from raw data, indicating that it is real, not interference, and that Bolyard is likely the discoverer of one of only about 30 rotating radio transients known. Suddenly, Bolyard said, he wasn't tired anymore. "That news made me full

  11. Data mining algorithm for discovering matrix association regions (MARs)

    Science.gov (United States)

    Singh, Gautam B.; Krawetz, Shephan A.

    2000-04-01

    Lately, there has been considerable interest in applying Data Mining techniques to scientific and data analysis problems in bioinformatics. Data mining research is being fueled by novel application areas that are helping the development of newer applied algorithms in the field of bioinformatics, an emerging discipline representing the integration of biological and information sciences. This is a shift in paradigm from the earlier and the continuing data mining efforts in marketing research and support for business intelligence. The problem described in this paper is along a new dimension in DNA sequence analysis research and supplements the previously studied stochastic models for evolution and variability. The discovery of novel patterns from genetic databases as described is quite significant because biological patterns play an important role in a large variety of cellular processes and constitute the basis for gene therapy. Biological databases containing the genetic codes from a wide variety of organisms, including humans, have continued their exponential growth over the last decade. At the time of this writing, the GenBank database contains over 300 million sequences and over 2.5 billion characters of sequenced nucleotides. The focus of this paper is on developing a general data mining algorithm for discovering regions of locus control, i.e. those regions that are instrumental for determining cell type. One such type of element of locus control are the MARs or the Matrix Association Regions. Our limited knowledge about MARs has hampered their detection using classical pattern recognition techniques. Consequently, their detection is formulated by utilizing a statistical interestingness measure derived from a set of empirical features that are known to be associated with MARs. This paper presents a systematic approach for finding associations between such empirical features in genomic sequences, and for utilizing this knowledge to detect biologically interesting

  12. Classifying transcription factor targets and discovering relevant biological features

    Directory of Open Access Journals (Sweden)

    DeLisi Charles

    2008-05-01

    Full Text Available Abstract Background An important goal in post-genomic research is discovering the network of interactions between transcription factors (TFs and the genes they regulate. We have previously reported the development of a supervised-learning approach to TF target identification, and used it to predict targets of 104 transcription factors in yeast. We now include a new sequence conservation measure, expand our predictions to include 59 new TFs, introduce a web-server, and implement an improved ranking method to reveal the biological features contributing to regulation. The classifiers combine 8 genomic datasets covering a broad range of measurements including sequence conservation, sequence overrepresentation, gene expression, and DNA structural properties. Principal Findings (1 Application of the method yields an amplification of information about yeast regulators. The ratio of total targets to previously known targets is greater than 2 for 11 TFs, with several having larger gains: Ash1(4, Ino2(2.6, Yaf1(2.4, and Yap6(2.4. (2 Many predicted targets for TFs match well with the known biology of their regulators. As a case study we discuss the regulator Swi6, presenting evidence that it may be important in the DNA damage response, and that the previously uncharacterized gene YMR279C plays a role in DNA damage response and perhaps in cell-cycle progression. (3 A procedure based on recursive-feature-elimination is able to uncover from the large initial data sets those features that best distinguish targets for any TF, providing clues relevant to its biology. An analysis of Swi6 suggests a possible role in lipid metabolism, and more specifically in metabolism of ceramide, a bioactive lipid currently being investigated for anti-cancer properties. (4 An analysis of global network properties highlights the transcriptional network hubs; the factors which control the most genes and the genes which are bound by the largest set of regulators. Cell-cycle and

  13. Chandra Observations of Eight Sources Discovered by INTEGRAL

    Science.gov (United States)

    Tomsick, John A.; Krivonos, Roman; Wang, Qinan; Bodaghee, Arash; Chaty, Sylvain; Rahoui, Farid; Rodriguez, Jerome; Fornasini, Francesca M.

    2016-01-01

    We report on 0.3-10 keV observations with the Chandra X-ray Observatory of eight hard X-ray sources discovered within 8° of the Galactic plane by the International Gamma-ray Astrophysics Laboratory satellite. The short (˜5 ks) Chandra observations of the IGR source fields have yielded very likely identifications of X-ray counterparts for three of the IGR sources: IGR J14091-6108, IGR J18088-2741, and IGR J18381-0924. The first two have very hard spectra in the Chandra band that can be described by a power law with photon indices of Γ = 0.6 ± 0.4 and -{0.7}-0.3+0.4, respectively (90% confidence errors are given), and both have a unique near-IR counterpart consistent with the Chandra position. IGR J14091-6108 also displays a strong iron line and a relatively low X-ray luminosity, and we argue that the most likely source type is a cataclysmic variable (CV), although we do not completely rule out the possibility of a high mass X-ray binary. IGR J18088-2741 has an optical counterpart with a previously measured 6.84 hr periodicity, which may be the binary orbital period. We also detect five cycles of a possible 800-950 s period in the Chandra light curve, which may be the compact object spin period. We suggest that IGR J18088-2741 is also most likely a CV. For IGR J18381-0924, the spectrum is intrinsically softer with {{Γ }}={1.5}-0.4+0.5, and it is moderately absorbed, NH = (4 ± 1) × 1022 cm-2. There are two near-IR sources consistent with the Chandra position, and they are both classified as galaxies, making it likely that IGR J18381-0924 is an active galactic nucleus. For the other five IGR sources, we provide lists of nearby Chandra sources, which may be used along with further observations to identify the correct counterparts, and we discuss the implications of the low inferred Chandra count rates for these five sources.

  14. AP stars with resolved Zeeman split lines

    Science.gov (United States)

    Mathys, G.

    1990-06-01

    High-resolution, high SNR observations of a sample of sharp-lined A stars and of Ap stars showing resolved Zeeman split lines are presented. The Fe II lines 6147.7 A and 6149.2 A unexpectedly appear to be asymmetric in all stars where they are resolved. The blue component of the 6149.2 line, which is a Zeeman doublet, is deeper and narrower than its red component. For line 6147.7, whose Zeeman pattern does not differ much from a quadruplet, the red components are deeper than the blue ones. It is shown that a partial Paschen-Back effect can account for these properties. The potential implications of this finding for studies of magnetic Ap stars are discussed.

  15. Fully resolved simulations of particle sedimentation

    Science.gov (United States)

    Sierakowski, Adam; Wang, Yayun; Prosperetti, Andrea

    2014-11-01

    Progress in computational capabilities - and specifically in the realm of massively parallel architectures - render possible the simulation of fully resolved fluid-particle systems. This development will drastically improve physical understanding and modelling of these systems when the particle size is not negligible and their concentration appreciable. Using a newly developed GPU-centric implementation of the Physalis method for the solution of the incompressible Navier-Stokes equations in the presence of finite-sized spheres, we carry out fully resolved simulations of more than one thousand sedimenting spheres. We discuss the results of these simulations focusing on statistical aspects such as particle velocity fluctuations, particle pair distribution function, microstructure, and others. Supported by NSF Grant CBET 1335965.

  16. Time-resolved photoemission using attosecond streaking

    CERN Document Server

    Nagele, Stefan; Wais, Michael; Wachter, Georg; Burgdörfer, Joachim

    2014-01-01

    We theoretically study time-resolved photoemission in atoms as probed by attosecond streaking. We review recent advances in the study of the photoelectric effect in the time domain and show that the experimentally accessible time shifts can be decomposed into distinct contributions that stem from the field-free photoionization process itself and from probe-field induced corrections. We perform accurate quantum-mechanical as well as classical simulations of attosecond streaking for effective one-electron systems and determine all relevant contributions to the time delay with attosecond precision. In particular, we investigate the properties and limitations of attosecond streaking for the transition from short-ranged potentials (photodetachment) to long-ranged Coulomb potentials (photoionization). As an example for a more complex system, we study time-resolved photoionization for endohedral fullerenes $A$@$\\text{C}_{60}$ and discuss how streaking time shifts are modified due to the interaction of the $\\text{C}_...

  17. Time-resolved photoemission using attosecond streaking

    Science.gov (United States)

    Nagele, S.; Pazourek, R.; Wais, M.; Wachter, G.; Burgdörfer, J.

    2014-04-01

    We theoretically study time-resolved photoemission in atoms as probed by attosecond streaking. We review recent advances in the study of the photoelectric efect in the time domain and show that the experimentally accessible time shifts can be decomposed into distinct contributions that stem from the feld-free photoionization process itself and from probe-field induced corrections. We perform accurate quantum-mechanical as well as classical simulations of attosecond streaking for efective one-electron systems and determine all relevant contributions to the time delay with attosecond precision. In particular, we investigate the properties and limitations of attosecond streaking for the transition from short-ranged potentials (photodetachment) to long-ranged Coulomb potentials (photoionization). As an example for a more complex system, we study time-resolved photoionization for endohedral fullerenes A@C60 and discuss how streaking time shifts are modifed due to the interaction of the C60 cage with the probing infrared streaking field.

  18. Component resolved testing for allergic sensitization

    DEFF Research Database (Denmark)

    Skamstrup Hansen, Kirsten; Poulsen, Lars K

    2010-01-01

    disease. Novel tools to predict severe outcomes and to plan for allergen-specific treatment are necessary, and because only a small amount of blood is needed to test for a multitude of allergens and allergenic components, component resolved diagnostics is promising. A drawback is the risk of overdiagnosis......Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergic...... and misinterpretation of the complex results of such tests. Also, the practical use and selection of allergenic components need to be evaluated in large studies including well-characterized patients and healthy, sensitized controls and with representation of different geographical regions....

  19. The warped, resolved, deformed conifold gets flavoured

    CERN Document Server

    Gaillard, Jerome; Nunez, Carlos; Papadimitriou, Ioannis

    2011-01-01

    We discuss a simple transformation that allows to generate SU(3) structure solutions of Type IIB supergravity with RR fluxes, starting from non-Kahler solutions of Type I supergravity. The method may be applied also in the presence of supersymmetric source branes. We apply this transformation to a solution describing fivebranes wrapped on the two-sphere of the resolved conifold with additional flavour fivebrane sources. The resulting solution is a generalisation of the resolved deformed conifold solution of Butti et al. by the addition of D5 brane and D3 brane sources. We propose that this solution may be interpreted in terms of a combined effect of Higgsing and cascade of Seiberg dualities in the dual field theory.

  20. The Most Distant Object Yet Discovered in the Universe

    Science.gov (United States)

    2009-04-01

    ESO's Very Large Telescope has shown that a faint gamma-ray burst detected last Thursday is the signature of the explosion of the earliest, most distant known object in the Universe (a redshift of 8.2). The explosion apparently took place more than 13 billion years ago, only about 600 million years after the Big Bang. ESO PR Photo 17a/09 Artist's impression of a gamma-ray burst Gamma-ray bursts (GRBs) are powerful flashes of energetic gamma-rays lasting from less than a second to several minutes. They release a tremendous amount of energy in this short time making them the most powerful events in the Universe. They are thought to be mostly associated with the explosion of stars that collapse into black holes. The gamma-ray burst GRB 090423 was detected by the NASA/STFC/ASI Swift satellite during the morning (CEST) of Thursday 23 April 2009. The 10 second burst was located in the constellation of Leo (the Lion). It was soon being followed by a whole range of telescopes on the ground, including the 2.2-metre ESO/MPG telescope at La Silla and ESO's Very Large Telescope (VLT) at Paranal, both in Chile. VLT infrared observations, made 17 hours after the burst detection, allowed astronomers to establish the distance to the explosion. "We find that the light coming from the explosion has been stretched, or redshifted, considerably by the expansion of the Universe", says Nial Tanvir, the leader of the team who made the VLT observations. "With a redshift of 8.2 this is the most remote gamma-ray burst ever detected, and also the most distant object ever discovered -- by some way." Because light moves at a finite speed, looking farther into the Universe means looking back in time. The explosion occurred when the Universe was about 600 million years old, less than 5 percent of its current age. It is believed that the very first stars only formed when the Universe was between 200 and 400 million years old. "This discovery proves the importance of gamma-ray bursts in probing the

  1. Polarized Imaging Nephelometer Scattering Measurements from the Winter of 2013 Discover-AQ Field Mission

    Science.gov (United States)

    Espinosa, R.; Martins, J.; Dolgos, G.; Dubovik, O.; Ziemba, L. D.; Beyersdorf, A. J.

    2013-12-01

    the Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (Discover-AQ) mission. This presentation will focus on the results of the PI-Neph's twelve successful science flights during this past winter's Discover-AQ mission. These flights focused primarily on vehicle traffic, agriculture and biomass burning emissions over the San Joaquin Valley in central California. PI-Neph scattering data from this mission will be analyzed with an emphasis on evaluating horizontal, vertical and temporal variation in the sampled aerosol to asses the reliability of column measurements made by remote sensing platforms in determining air quality. Measured PI-Neph phase functions during spirals over AERONET (AErosol RObotic NETwork) stations will also be compared with retrieved phase functions from AERONET. In an effort to further validate AERONET retrievals an inversion method (Dubovik et al., J. Geophys. Res., 111, D11208, doi:10.1029/2005JD006619d, 2006) similar to the AERONET inversion will be applied to PI-NEPH data to obtain size distribution estimates. These results will be compared to measurements of the same sample made by particle counters on board the aircraft.

  2. Monitoring Tropospheric Ozone Enhancement in the Front Range Using the Gsfc Tropoz DIAL during Discover - AQ 2014

    Science.gov (United States)

    Sullivan, J. T.; McGee, T. J.; Hoff, R. M.; Twigg, L.; Sumnicht, G. K.

    2014-12-01

    Tropospheric ozone profiles have been retrieved from the new ground based National Aeronautics and Space Administration (NASA) Goddard Space Flight Center TROPospheric OZone DIfferential Absorption Lidar (GSFC TROPOZ DIAL) in Fort Collins, CO from 200 m to 16 km AGL. These measurements were taken as part of NASA's DISCOVER-AQ campaign in July/August 2014. Measurements were made during simultaneous aircraft spirals over the lidar site as well as collocated ozonesonde launches. Ozone enhancement from local sources typically occurred in the mid-afternoon convection period, especially when there was light winds and low cloud cover. Interesting ozone profiles and time series data will be shown. Current atmospheric satellite instruments cannot peer through the optically thick stratospheric ozone layer to remotely sense boundary layer tropospheric ozone. In order to monitor this lower ozone more effectively, the Tropospheric Ozone Lidar Network (TOLNet) has been developed, which currently consists of five stations across the US. Three of these lidars, including the GSFC TROPOZ DIAL, recorded measurements during the DISCOVER-AQ campaign. The GSFC TROPOZ DIAL is based on the Differential Absorption Lidar (DIAL) technique, which currently detects two wavelengths, 289 and 299 nm. Ozone is absorbed more strongly at 289 nm than at 299 nm. The DIAL technique exploits this difference between the returned backscatter signals to obtain the ozone number density as a function of altitude. The transmitted wavelengths are generated by focusing the output of a quadrupled Nd:YAG laser beam (266 nm) into a pair of Raman cells, filled with high pressure hydrogen and deuterium. Stimulated Raman Scattering (SRS) within the focus generates a significant fraction of the pump energy at the first Stokes shift. With the knowledge of the ozone absorption coefficient at these two wavelengths, the range resolved number density can be derived.

  3. Resolving the Birth of High-Mass Binary Stars

    Science.gov (United States)

    Kohler, Susanna

    2017-02-01

    New observations may help us to learn more about the birth of high-mass star systems. For the first time, scientists have imaged a very young, high-mass binary system and resolved the individual disks that surround each star and the binary.Massive MultiplesIts unusually common for high-mass stars to be discovered in multiple-star systems. More than 80% of all O-type stars which have masses greater than 16 times that of the Sun are in close multiple systems, compared with a multiplicity fraction of only 20% for stars of 3 solar masses, for instance.Reconstructed VLTI observations of the two components of the high-mass binary IRAS17216-3801. [Adapted from Kraus et al. 2017]Why do more massive stars preferentially form in multiple-star systems? Many different models of high-mass star formation have been invoked to explain this observation, but before we can better understand the process, we need better observations. In particular, past observations have placed few constraints on the architecture and disk structure of early high-mass stars.Conveniently, a team of scientists led by Stefan Kraus (University of Exeter) may have found exactly what we need: a high-mass protobinary that is still in the process of forming. Using ESOs Very Large Telescope Interferometer (VLTI), Kraus and collaborators have captured the first observations of a very young, high-mass binary system in which the circumbinary disk and the two circumstellar dust disks could all be spatially resolved.Clues from Resolved DisksThe VLTI near-infrared observations reveal that IRAS17216-3801, originally thought to be a single high-mass star, is instead a close binary separated by only 170 AU. Its two components are both surrounded by disks from which the protostars are actively accreting mass, and both of these circumstellar disks are strongly misaligned with respect to the separation vector of the binary. This confirms that the system is very young, as tidal forces havent yet had time to align the disks

  4. Open Imaging Nephelometer Scattering Measurements from the 2014 Discover-AQ Field Mission

    Science.gov (United States)

    Espinosa, R.; Orozco, D.; Dolgos, G.; Martins, J. V.

    2014-12-01

    After greenhouse gases, aerosols are thought to have the largest contribution to total atmospheric radiative forcing, but they are frequently cited as the single largest source of uncertainty among all anthropogenic radiative forcing components. Remote sensing allows for global measurements of aerosol properties, however validation of these measurements and the climatological assumptions used in their retrieval algorithms require high quality in situ sampling. The Laboratory for Aerosols, Clouds and Optics (LACO) at the University of Maryland Baltimore County (UMBC) has developed the Imaging Nephelometer, a novel and highly accurate instrument concept designed to significantly aid in situ optical scattering measurements. Imaging Nephelometers allow for measurements of scattering coefficient, phase function and polarized phase function over a wide angular range of 2 to 178 degrees with an angular resolution of less than half of a degree. The simple layout of these devices also permits the construction of an instrument that is compact enough to be deployed on a variety of airborne platforms. Additionally, a version of this instrument that is capable of in situ sampling in open-air, free from sample biases potentially introduced by an inlet or containment apparatus, has recently been constructed. This instrument, known as the Open Imaging NEPHelometer (OI-NEPH), was flown on the P3 aircraft in the summer of 2014 during the Colorado portion of the Discover-AQ field mission (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality). This presentation will focus on the results of the OI-NEPH's successful science flights during this field experiment. The P3's flights during this mission focused primarily on vehicle, agriculture, biomass burning and industrial processing emissions over the Colorado Front Range. Emphasis will be placed on any observed differences in scattering properties between the measurements

  5. Chandra Discovers Eruption and Pulsation in Nova Outburst

    Science.gov (United States)

    2001-09-01

    NASA's Chandra X-ray Observatory has discovered a giant outburst of X-rays and unusual cyclical pulsing from a white dwarf star that is closely orbiting another star -- the first time either of these phenomena has been seen in X-rays. The observations are helping scientists better understand the thermonuclear explosions that occur in certain binary star systems. The observations of Nova Aquilae were reported today at the "Two Years of Science with Chandra" symposium by an international team led by Sumner Starrfield of Arizona State University. "We found two important results in our Chandra observations. The first was an underlying pulsation every 40 minutes in the X-ray brightness, which we believe comes from the cyclical expansion and contraction of the outer layers of the white dwarf," said Starrfield. "The other result was an enormous flare of X-rays that lasted for 15 minutes. Nothing like this has been seen before from a nova, and we don't know how to explain it." Novas occur on a white dwarf (a star which used up all its nuclear fuel and shrank to roughly the size of the Earth) that is orbiting a normal size star. Strong gravity tides drag hydrogen gas off the normal star and onto the white dwarf, where it can take more than 100,000 years for enough hydrogen to accumulate to ignite nuclear fusion reactions. Gradually, these reactions intensify until a cosmic-sized hydrogen bomb blast results. The outer layers of the white dwarf are then blown away, producing a nova outburst that can be observed for a period of months to years as the material expands into space. "Chandra has allowed us to see deep into the gases ejected by this giant explosion and extract unparalleled information on the evolution of the white dwarf whose surface is exploding," said Jeremy Drake of the Harvard-Smithsonian Center for Astrophysics. The brightening of Nova Aquilae was first detected by optical astronomers in December 1999. "Although this star is at a distance of more than 6

  6. Time resolved spectroscopic studies on some nanophosphors

    Indian Academy of Sciences (India)

    Harish Chander; Santa Chawla

    2008-06-01

    Time resolved spectroscopy is an important tool for studying photophysical processes in phosphors. Present work investigates the steady state and time resolved photoluminescence (PL) spectroscopic characteristics of ZnS, ZnO and (Zn, Mg)O nanophosphors both in powder as well as thin film form. Photoluminescence (PL) of ZnS nanophosphors typically exhibit a purple/blue emission peak termed as self activated (SA) luminescence and emission at different wavelengths arising due to dopant impurities e.g. green emission for ZnS : Cu, orange emission for ZnS : Mn and red emission for ZnS : Eu. The lifetimes obtained from decay curves range from ns to ms level and suggest the radiative recombination path involving donor–acceptor pair recombination or internal electronic transitions of the impurity atom. A series of ZnMgO nanophosphor thin films with varied Zn : Mg ratios were prepared by chemical bath deposition. Photoluminescence (PL) excitation and emission spectra exhibit variations with changing Mg ratio. Luminescence lifetime as short as 10-10 s was observed for ZnO and ZnMgO (100 : 10) nanophosphors. With increasing Mg ratio, PL decay shifts into microsecond range. ZnO and ZnMgO alloys up to 50% Mg were prepared as powder by solid state mixing and sintering at high temperature in reducing atmosphere. Time resolved decay of PL indicated lifetime in the microsecond time scale. The novelty of the work lies in clear experimental evidence of dopants (Cu, Mn, Eu and Mg) in the decay process and luminescence life times in II–VI semiconductor nanocrystals of ZnS and ZnO. For ZnS, blue self activated luminescence decays faster than Cu and Mn related emission. For undoped ZnO nanocrystals, PL decay is in the nanosecond range whereas with Mg doping the decay becomes much slower in the microsecond range.

  7. Spatially Resolved Analysis of Bragg Selectivity

    Directory of Open Access Journals (Sweden)

    Tina Sabel

    2015-11-01

    Full Text Available This paper targets an inherent control of optical shrinkage in photosensitive polymers, contributing by means of spatially resolved analysis of volume holographic phase gratings. Point by point scanning of the local material response to the Gaussian intensity distribution of the recording beams is accomplished. Derived information on the local grating period and grating slant is evaluated by mapping of optical shrinkage in the lateral plane as well as through the depth of the layer. The influence of recording intensity, exposure duration and the material viscosity on the Bragg selectivity is investigated.

  8. Spatially resolved measurement of rock core porosity.

    Science.gov (United States)

    Marica, F; Chen, Q; Hamilton, A; Hall, C; Al, T; Balcom, B J

    2006-01-01

    Density weighted, centric scan, Conical SPRITE MRI techniques are applied in the current work for local porosity measurements in fluid saturated porous media. The methodology is tested on a series of sandstone core samples. These samples vary in both porosity and degree of local heterogeneity due to bedding plane structure. The MRI porosity measurement is in good agreement with traditional gravimetric measurements of porosity. Spatially resolved porosity measurements reveal significant porosity variation in some samples. This novel MRI technique should have applications to the characterization of local porosity in a wide variety of porous media.

  9. Superlubricity: A Paradox about Confined Fluids Resolved

    Science.gov (United States)

    Zhu, Yingxi; Granick, Steve

    2004-08-01

    Using the method of Frantz and Salmeron to cleave mica [Tribol. Lett.TRLEFS1023-8883 5, 151 (1998)10.1023/A:1019149910047] we investigate alkane fluids in a surface forces apparatus and confirm several predictions of molecular dynamics (MD) simulation. An oscillatory force-distance profile is observed for the methyl-branched alkane, squalane. Boundary slip is inferred from the frictional sliding of molecularly thin fluids and also from the hydrodynamic flow of thicker films. These findings resolve the paradox that prior experiments disagreed with these aspects of MD predictions, and demonstrate that exceptionally low energy dissipation is possible when fluids move past solid surfaces that are sufficiently smooth.

  10. Angle-resolved time delay in photoemission

    CERN Document Server

    Wätzel, Jonas; Pavlyukh, Yaroslav; Berakdar, Jamal

    2014-01-01

    We investigate theoretically the relative time delay of photoelectrons originating from different atomic subshells of noble gases. This quantity was measured via attosecond streaking and studied theoretically by Schultze et al. [Science 328, 1658 (2010)] for neon. A substantial discrepancy was found between the measured and the calculated values of the relative time delay. Several theoretical studies were put forward to resolve this issue, e.g., by including correlation effects. In the present paper we explore a further aspect, namely the directional dependence of time delay. In contrast to neon, for argon target a strong angular dependence of time delay is found near a Cooper minimum.

  11. Inflation on the resolved warped deformed conifold

    CERN Document Server

    Buchel, A

    2006-01-01

    Braneworld inflation on the resolved warped deformed conifold is represented by the dynamics of a D3-brane probe with the world volume of a brane spanning the large dimensions of the observable Universe. This model was recently proposed as a string theory candidate for slow-roll inflationary cosmology in hep-th/0511254. During inflation, the scalar curvature of the Universe is determined by the Hubble scale. We argue that taking into account the curvature of the inflationary Universe renders dynamics of the D3-brane fast-roll deep inside the warped throat.

  12. Some results on resolvable incomplete block designs

    Institute of Scientific and Technical Information of China (English)

    LIU; Minqian; FANG; Kaitai

    2005-01-01

    This paper is concerned with the uniformity of a certain kind of resolvable incomplete block (RIB for simplicity) design which is called the PRIB design here. A sufficient and necessary condition is obtained, under which a PRIB design is the most uniform in the sense of a discrete discrepancy measure, and the uniform PRIB design is shown to be connected. A construction method for such designs via a kind of U-type designs is proposed, and an existence result of these designs is given. This method sets up an important bridge between PRIB designs and U-type designs.

  13. Achieving patient satisfaction: resolving patient complaints.

    Science.gov (United States)

    Oxler, K F

    1997-07-01

    Patients demand to be active participants on and partners with the health care team to design their care regimen. Patients bring unique perceptions and expectations and use these to evaluate service quality and satisfaction. If customer satisfaction is not achieved and a patient complaint results, staff must have the skills to respond and launch a service recovery program. Service recovery, when done with style and panache, can retain loyal customers. Achieving patient satisfaction and resolving patient complaints require commitment from top leadership and commitment from providers to dedicate the time to understand their patients' needs.

  14. Discovering Hot Topics On Social Network Based On Improving The Aging Theory

    Directory of Open Access Journals (Sweden)

    Thanh Ho

    Full Text Available In this paper, we focus on discovering information on the social network to discover automatically the hot topics in real time. We suggest using aging theory for finding hot topics and using the tools for processing natural language and data processing mo ...

  15. 32 CFR 644.533 - Contamination discovered after return of land to owner, or sale.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Contamination discovered after return of land to owner, or sale. 644.533 Section 644.533 National Defense Department of Defense (Continued) DEPARTMENT OF... Other Contamination from Proposed Excess Land and Improvements § 644.533 Contamination discovered...

  16. 48 CFR 30.606 - Resolving cost impacts.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Administration 30.606 Resolving cost... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Resolving cost impacts. 30... negotiating and resolving the cost impact when the estimated cost impact on any of their contracts is at...

  17. LIGO Discovers the Merger of Two Black Holes

    Science.gov (United States)

    Kohler, Susanna

    2016-02-01

    is: how do binary black holes form? Two primary mechanisms have been proposed:A binary star system contains two stars that are each massive enough to individually collapse into a black hole. If the binary isnt disrupted during the two collapse events, this forms an isolated black-hole binary.Single black holes form in dense cluster environments and then because they are the most massive objects sink to the center of the cluster. There they form pairs through dynamical interactions.Now that were able to observe black-hole binaries through gravitational-wave detections, one way we could distinguish between the two formation mechanisms is from spin measurements. If we discover a clear preference for the misalignment of the two black holes spins, this would favor formation in clusters, where theres no reason for the original spins to be aligned.The current, single detection is not enough to provide constraints, but if we can compile a large enough sample of events, we can start to present a statistical case favoring one channel over the other.What does GW150914 mean for the future of gravitational-wave detection?The fact that Advanced LIGO detected an event even before the start of its first official observing run is certainly promising! The LIGO team estimates that the volume the detectors can probe will still increase by at least a factor of ~10 as the observing runs become more sensitive and of longer duration.Aerial view of the Virgo interferometer near Pisa, Italy. [Virgo Collaboration]In addition, LIGO is not alone in the gravitational-wave game. LIGOs counterpart in Europe, Virgo, is also undergoing design upgrades to increase its sensitivity. Within this year, Virgo should be able to take data simultaneously with LIGO, allowing for better localization of sources. And the launch of (e)LISA, ESAs planned space-based interferometer, will grant us access to a new frequency range, opening a further window to the gravitational-wave sky.The detection of GW150914 marks

  18. Resolving The Moth at Millimeter Wavelengths

    CERN Document Server

    Ricarte, Angelo; Hughes, A Meredith; Duchêne, Gaspard; Williams, Jonathan P; Andrews, Sean M; Wilner, David J

    2013-01-01

    HD 61005, also known as "The Moth," is one of only a handful of debris disks that exhibit swept-back "wings" thought to be caused by interaction with the ambient interstellar medium (ISM). We present 1.3 mm Submillimeter Array (SMA) observations of the debris disk around HD 61005 at a spatial resolution of 1.9 arcsec that resolve the emission from large grains for the first time. The disk exhibits a double-peaked morphology at millimeter wavelengths, consistent with an optically thin ring viewed close to edge-on. To investigate the disk structure and the properties of the dust grains we simultaneously model the spatially resolved 1.3 mm visibilities and the unresolved spectral energy distribution. The temperatures indicated by the SED are consistent with expected temperatures for grains close to the blowout size located at radii commensurate with the millimeter and scattered light data. We also perform a visibility-domain analysis of the spatial distribution of millimeter-wavelength flux, incorporating constr...

  19. Healthcare Teams Neurodynamically Reorganize When Resolving Uncertainty

    Directory of Open Access Journals (Sweden)

    Ronald Stevens

    2016-11-01

    Full Text Available Research on the microscale neural dynamics of social interactions has yet to be translated into improvements in the assembly, training and evaluation of teams. This is partially due to the scale of neural involvements in team activities, spanning the millisecond oscillations in individual brains to the minutes/hours performance behaviors of the team. We have used intermediate neurodynamic representations to show that healthcare teams enter persistent (50–100 s neurodynamic states when they encounter and resolve uncertainty while managing simulated patients. Each of the second symbols was developed situating the electroencephalogram (EEG power of each team member in the contexts of those of other team members and the task. These representations were acquired from EEG headsets with 19 recording electrodes for each of the 1–40 Hz frequencies. Estimates of the information in each symbol stream were calculated from a 60 s moving window of Shannon entropy that was updated each second, providing a quantitative neurodynamic history of the team’s performance. Neurodynamic organizations fluctuated with the task demands with increased organization (i.e., lower entropy occurring when the team needed to resolve uncertainty. These results show that intermediate neurodynamic representations can provide a quantitative bridge between the micro and macro scales of teamwork.

  20. The RESOLVE Survey: REsolved Spectroscopy Of a Local VolumE

    Science.gov (United States)

    Kannappan, Sheila; Norris, M. A.; Eckert, K. D.; Moffett, A. J.; Stark, D. V.; Haynes, M. P.; Giovanelli, R.; Berlind, A. A.; Wei, L. H.; Baker, A. J.; Vogel, S. N.; Hendel, D. A.; RESOLVE Team

    2011-01-01

    The RESOLVE Survey is a volume-limited census of stellar, gas, and dynamical mass as well as merging and star formation within 53,000 cubic Mpc of the nearby cosmic web in two long equatorial strips. The survey's primary science drivers include relating the galaxy velocity and mass functions to environment, constraining the "missing baryons" problem from a complete accounting perspective, and understanding galaxy disk building in large-scale context. RESOLVE's unique data product is high-resolution multiple-longslit spectroscopy, targeting all 1500 galaxies with baryonic (stellar + cold gas) mass > 109 Msun in the volume. Combined with a complete redshift survey, this spectroscopy will enable an unprecedented high dynamic-range view of how kinematically estimated mass is distributed on scales from dwarf galaxies to clusters. To trace stellar and gas mass, RESOLVE is drawing on deep public surveys at UV, optical, IR, and radio wavelengths, most notably the 21cm ALFALFA Survey. Here we present early results: (1) statistics of our efforts to recover galaxies missed by RESOLVE's parent survey, the SDSS; (2) calibration of indirect atomic and molecular gas estimators to supplement direct observations; (3) progress toward optimizing stellar mass and environment measures; and (4) a first installment of kinematic data focusing on S0 galaxies. This work is supported by the National Science Foundation under CAREER award 0955368.

  1. Resolved motion rate and resolved acceleration servo-control of wheeled mobile robots

    Energy Technology Data Exchange (ETDEWEB)

    Muir, P.F.; Neuman, C.P. (Sandia National Labs., Albuquerque, NM (USA); Carnegie-Mellon Univ., Pittsburgh, PA (USA). Dept. of Electrical and Computer Engineering)

    1989-01-01

    Accurate motion control of wheeled mobile robots (WMRs) is required for their application to autonomous, semi-autonomous and teleoperated tasks. The similarities between WMRs and stationary manipulators suggest that current, successful, model-based manipulator control algorithms may be applied to WMRs. Special characteristics of WMRs including higher-pairs, closed-chains, friction and unactuated and unsensed joints require innovative modeling methodologies. The WMR modeling challenge has been recently overcome, thus enabling the application of manipulator control algorithms to WMRs. This realization lays the foundation for significant technology transfer from manipulator control to WMR control. We apply two Cartesian-space manipulator control algorithms: resolved motion rate (kinematics-based) and resolved acceleration (dynamics-based) control to WMR servo-control. We evaluate simulation studies of two exemplary WMRs: Uranus (a three degree-of-freedom WMR constructed at Carnegie Mellon University), and Bicsun-Bicas (a two degree-of-freedom WMR being constructed at Sandia National Laboratories) under the control of these algorithms. Although resolved motion rate servo-control is adequate for the control of Uranus, resolved acceleration servo-control is required for the control of the mechanically simpler Bicsun-Bicas because it exhibits more dynamic coupling and nonlinearities. Successful accurate motion control of these WMRs in simulation is driving current experimental research studies. 18 refs., 7 figs., 5 tabs.

  2. Characterization and verification of ACAM slit functions for trace gas retrievals during the 2011 DISCOVER-AQ flight campaign

    Directory of Open Access Journals (Sweden)

    C. Liu

    2014-11-01

    Full Text Available The Airborne Compact Atmospheric Mapper (ACAM, an ultraviolet/visible/near-infrared spectrometer, has been flown on board the NASA UC-12 aircraft during the DISCOVER-AQ (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality campaigns to provide remote sensing observations of tropospheric and boundary layer pollutants from its radiance measurements. To improve the trace gas retrieval from ACAM measurements, we perform detailed characterization and verification of ACAM slit functions. The wavelengths and slit functions of ACAM measurements are characterized for the air quality channel (~304–500 nm through cross-correlation with a high-resolution solar irradiance reference spectrum after necessarily accounting for atmospheric gas absorption and the Ring effect in the calibration process. The derived slit functions, assuming a hybrid combination of asymmetric Gaussian and top-hat slit functions, agree very well with the laboratory-measured slit functions. Comparisons of trace gas retrievals between using derived and measured slit functions demonstrate that the cross-correlation technique can be reliably used to characterize slit functions for trace gas retrievals.

  3. Rotationally resolved electronic spectroscopy of 5-methoxyindole.

    Science.gov (United States)

    Brand, Christian; Oeltermann, Olivia; Pratt, David; Weinkauf, Rainer; Meerts, W Leo; van der Zande, Wim; Kleinermanns, Karl; Schmitt, Michael

    2010-07-14

    Rotationally resolved electronic spectra of the vibrationless origin and of eight vibronic bands of 5-methoxyindole (5MOI) have been measured and analyzed using an evolutionary strategy approach. The experimental results are compared to the results of ab initio calculations. All vibronic bands can be explained by absorption of a single conformer, which unambiguously has been shown to be the anti-conformer from its rotational constants and excitation energy. For both anti- and syn-conformers, a (1)L(a)/(1)L(b) gap larger than 4000 cm(-1) is calculated, making the vibronic coupling between both states very small, thereby explaining why the spectrum of 5MOI is very different from that of the parent molecule, indole.

  4. Spatially Resolved Images and Solar Irradiance Variability

    Indian Academy of Sciences (India)

    R. Kariyappa

    2008-03-01

    The Sun is the primary source of energy that governs both the terrestrial climate and near-earth space environment. Variations in UV irradiances seen at earth are the sum of global (solar dynamo) to regional (active region, plage, network, bright points and background) solar magnetic activities that can be identified through spatially resolved photospheric, chromospheric and coronal features. In this research, the images of CaII K-line (NSO/Sac Peak) have been analysed to segregate the various chromospheric features.We derived the different indices and estimated their contribution from the time series data to total CaII K emission flux and UV irradiance variability. A part of the important results from this research is discussed in this paper.

  5. Resolving Implementation Ambiguity and Improving SURF

    CERN Document Server

    Abeles, Peter

    2012-01-01

    Speeded Up Robust Features (SURF) has emerged as one of the more popular feature descriptors and detectors in recent years. Due to SURF's complexity and ambiguities found in its description, performance and algorithmic details between these implementations vary widely. To resolve these ambiguities a set of general techniques for feature stability is defined based on the smoothness rule and applied to SURF. Additional new improvements to SURF are proposed for speed and stability. To illustrate the importance of these implementation details, a performance study of popular SURF implementations is done. By utilizing all the suggested improvements it is possible to create a SURF implementation which is several times faster and/or more stable.

  6. Radiofrequency encoded angular-resolved light scattering

    DEFF Research Database (Denmark)

    Buckley, Brandon W.; Akbari, Najva; Diebold, Eric D.

    2015-01-01

    The sensitive, specific, and label-free classification of microscopic cells and organisms is one of the outstanding problems in biology. Today, instruments such as the flow cytometer use a combination of light scatter measurements at two distinct angles to infer the size and internal complexity...... of cells at rates of more than 10,000 per second. However, by examining the entire angular light scattering spectrum it is possible to classify cells with higher resolution and specificity. Current approaches to performing these angular spectrum measurements all have significant throughput limitations...... Encoded Angular-resolved Light Scattering (REALS), this technique multiplexes angular light scattering in the radiofrequency domain, such that a single photodetector captures the entire scattering spectrum from a particle over approximately 100 discrete incident angles on a single shot basis. As a proof...

  7. Space-Time Resolved Capillary Wave Turbulence

    CERN Document Server

    Berhanu, Michael

    2012-01-01

    We report experiments on the full space and time resolved statistics of capillary wave turbulence at the air-water interface. The three-dimensional shape of the free interface is measured as a function of time by using the optical method of Diffusing Light Photography associated with a fast camera. Linear and nonlinear dispersion relations are extracted from the spatio-temporal power spectrum of wave amplitude. When wave turbulence regime is reached, we observe power-law spectra both in frequency and in wave number, whose exponents are found in agreement with the predictions of capillary wave turbulence theory. Finally, the temporal dynamics of the spatial energy spectrum highlights the occurrence of stochastic bursts transferring wave energy through the spatial scales.

  8. Resolved Host Studies of Stellar Explosions

    CERN Document Server

    Levesque, Emily M

    2016-01-01

    The host galaxies of nearby (z<0.3) core-collapse supernovae and long-duration gamma-ray bursts offer an excellent means of probing the environments and populations that produce these events' varied massive progenitors. These same young stellar progenitors make LGRBs and SNe valuable and potentially powerful tracers of star formation, metallicity, the IMF, and the end phases of stellar evolution. However, properly utilizing these progenitors as tools requires a thorough understanding of their formation and, consequently, the physical properties of their parent host environments. This review looks at some of the recent work on LGRB and SN hosts with resolved environments that allows us to probe the precise explosion sites and surrounding environments of these events in incredible detail.

  9. Atomically resolved images of lithium purple bronze

    Energy Technology Data Exchange (ETDEWEB)

    Klinke, Melanie; Bienert, Robert; Waelsch, Michael; Podlich, Tatjana; Matzdorf, Rene [Experimentalphysik II, Universitaet Kassel (Germany); Jin, Rongying [Department of Physics and Astronomy, Lousiana State University (United States)

    2012-07-01

    The lithium molybdenum purple bronze Li{sub 0.9}Mo{sub 6}O{sub 17} is a quasi 1D metal at room temperature showing Luttinger liquid physics. The highly anisotropic conductivity runs along the crystallographic b axis where Mo-O chains, formed by the shared edges of the MoO{sub 6} octahedra, provide the electrical transport. Li{sub 0.9}Mo{sub 6}O{sub 17} samples were investigated with low-temperature scanning tunneling microscopy and spectroscopy. By cleaving the samples at low temperatures (60 K) we obtained atomically resolved images of the surface. In these images the Mo-O chains are visible, which are covered by layers of MoO{sub 6} octahedra and MoO{sub 4} tetrahedra.

  10. Resolving mixing in Smoothed Particle Hydrodynamics

    CERN Document Server

    Read, J I; Agertz, O

    2009-01-01

    Standard formulations of smoothed particle hydrodynamics (SPH) are unable to resolve mixing at fluid boundaries. We use an error and stability analysis of the generalised SPH equations of motion to prove that this is due to two distinct problems. The first is a leading order error in the momentum equation. This should decrease with increasing neighbour number, but does not because numerical instabilities cause the kernel to be irregularly sampled. We identify two important instabilities: the clumping instability and the banding instability, and we show that both are cured by a suitable choice of kernel. The second problem is the local mixing instability (LMI). This occurs as particles attempt to mix on the kernel scale, but are unable to due to entropy conservation. The result is a pressure discontinuity at boundaries that pushes fluids of different entropy apart. We cure the LMI by using a temperature weighted density estimate that both reduces errors in the continuity equation and allows individual particle...

  11. Spatially resolved spectroscopy on semiconductor nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Roessler, Johanna

    2009-02-20

    Cleared edge overgrowth (CEO) nanostructures are identified and studied by 1D und 2D {mu}PL mapping scans and by time-resolved and power-dependent measurements. Distinct excitonic ground states of 2fold CEO QDs with large localization energies are achieved. The deeper localization reached as compared to the only other report on 2fold CEO QDs in literature is attributed to a new strain-free fabrication process and changed QW thickness in [001] growth. In order to achieve controlled manipulation of 2fold CEO QDs the concept of a CEO structure with three top gates and one back gate is presented. Due to the complexity of this device, a simpler test structure is realized. Measurements on this test structure confirm the necessity to either grow significantly thicker overgrowth layers or to provide separate top gates in all three spatial direction to controllably manipulate 2fold CEO QDs with an external electric field. (orig.)

  12. Resolving coastal conflicts using marine spatial planning.

    Science.gov (United States)

    Tuda, Arthur O; Stevens, Tim F; Rodwell, Lynda D

    2014-01-15

    We applied marine spatial planning (MSP) to manage conflicts in a multi-use coastal area of Kenya. MSP involves several steps which were supported by using geographical information systems (GISs), multi-criteria decision analysis (MCDA) and optimization. GIS was used in identifying overlapping coastal uses and mapping conflict hotspots. MCDA was used to incorporate the preferences of user groups and managers into a formal decision analysis procedure. Optimization was applied in generating optimal allocation alternatives to competing uses. Through this analysis three important objectives that build a foundation for future planning of Kenya's coastal waters were achieved: 1) engaging competing stakeholders; 2) illustrating how MSP can be adapted to aid decision-making in multi-use coastal regions; and 3) developing a draft coastal use allocation plan. The successful application of MSP to resolve conflicts in coastal regions depends on the level of stakeholder involvement, data availability and the existing knowledge base.

  13. Fermions in a warped resolved conifold

    CERN Document Server

    Dantas, D M; Almeida, C A S

    2013-01-01

    We investigated the localization of the spinorial field in a braneworld built as a warped product between a 3-brane and a 2-cycle of the resolved conifold. This scenario provides a geometric flow that controls the singularity at the origin and changes the properties of the fermion in this background. Furthermore, due the cylindrical symmetry according to the 3-brane and a smoothed warp factor, this geometry can be regarded as a near brane correction of the string-like branes. This geometry allows a normalizable and well-defined massless mode whose decay and value on the brane depend on the resolution parameter. For the Kaluza-Klein modes, resolution parameter also controls the height of the barrier of the volcano potential.

  14. Time-resolved photoabsorption in finite systems: A first-principles NEGF approach

    Science.gov (United States)

    Perfetto, E.; Uimonen, A.-M.; van Leeuwen, R.; Stefanucci, G.

    2016-03-01

    We describe a first-principles NonEquilibrium Green's Function (NEGF) approach to time-resolved photoabsortion spectroscopy in atomic and nanoscale systems. The method is used to highlight a recently discovered dynamical correlation effect in the spectrum of a Krypton gas subject to a strong ionizing pump pulse. We propose a minimal model that captures the effect, and study the performance of time-local approximations versus time-nonlocal ones. In particular we implement the time-local Hartree-Fock and Markovian second Born (2B) approximation as well as the exact adiabatic approximation within the Time-Dependent Density Functional Theory framework. For the time-nonlocal approximation we instead use the 2B one. We provide enough convincing evidence for the fact that a proper description of the spectrum of an evolving admixture of ionizing atoms requires the simultaneous occurrence of correlation and memory effects.

  15. Resolving local ambiguity using semantics of shape.

    Energy Technology Data Exchange (ETDEWEB)

    Diegert, Carl F.

    2010-05-01

    We demonstrate a new semantic method for automatic analysis of wide-area, high-resolution overhead imagery to tip and cue human intelligence analysts to human activity. In the open demonstration, we find and trace cars and rooftops. Our methodology, extended to analysis of voxels, may be applicable to understanding morphology and to automatic tracing of neurons in large-scale, serial-section TEM datasets. We defined an algorithm and software implementation that efficiently finds all combinations of image blobs that satisfy given shape semantics, where image blobs are formed as a general-purpose, first step that 'oversegments' image pixels into blobs of similar pixels. We will demonstrate the remarkable power (ROC) of this combinatorial-based work flow for automatically tracing any automobiles in a scene by applying semantics that require a subset of image blobs to fill out a rectangular shape, with width and height in given intervals. In most applications we find that the new combinatorial-based work flow produces alternative (overlapping) tracings of possible objects (e.g. cars) in a scene. To force an estimation (tracing) of a consistent collection of objects (cars), a quick-and-simple greedy algorithm is often sufficient. We will demonstrate a more powerful resolution method: we produce a weighted graph from the conflicts in all of our enumerated hypotheses, and then solve a maximal independent vertex set problem on this graph to resolve conflicting hypotheses. This graph computation is almost certain to be necessary to adequately resolve multiple, conflicting neuron topologies into a set that is most consistent with a TEM dataset.

  16. Lipoxins: nature's way to resolve inflammation

    Directory of Open Access Journals (Sweden)

    Chandrasekharan JA

    2015-09-01

    Full Text Available Jayashree A Chandrasekharan, Neelam Sharma-Walia HM Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAAbstract: An effective host defense mechanism involves inflammation to eliminate pathogens from the site of infection, followed by the resolution of inflammation and the restoration of tissue homeostasis. Lipoxins are endogenous anti-inflammatory, pro-resolving molecules that play a vital role in reducing excessive tissue injury and chronic inflammation. In this review, the mechanisms of action of lipoxins at the site of inflammation and their interaction with other cellular signaling molecules and transcription factors are discussed. Emphasis has also been placed on immune modulatory role(s of lipoxins. Lipoxins regulate components of both the innate and adaptive immune systems including neutrophils, macrophages, T-, and B-cells. Lipoxins also modulate levels of various transcription factors such as nuclear factor κB, activator protein-1, nerve growth factor-regulated factor 1A binding protein 1, and peroxisome proliferator activated receptor γ and control the expression of many inflammatory genes. Since lipoxins and aspirin-triggered lipoxins have clinical relevance, we discuss their important role in clinical research to treat a wide range of diseases like inflammatory disorders, renal fibrosis, cerebral ischemia, and cancer. A brief overview of lipoxins in viral malignancies and viral pathogenesis especially the unexplored role of lipoxins in Kaposi's sarcoma-associated herpes virus biology is also presented. Keywords: lipoxins, epi-lipoxins, inflammation, pro-resolving, aspirin-triggered lipoxins, cyclooxygenases, lipoxygenases, therapeutic potential, transcription factors, Kaposi's sarcoma-associated herpes virus

  17. A complete algorithm for automated discovering of a class of inequality_type theorems

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Making use of the discriminant sequence for polynomials, WR algorithm, Wu's elimination and a partial cylindrical algebraic decomposition, we present here a practical algorithm for automated inequality discovering which can discover new inequalities automatically without requiring to put forward any conjectures beforehand. That is complete for an extensive class of inequality_type theorems. Also this algorithm is applied to the classification of the real physical solutions of geometric constraint problems. Many inequalities with various backgrounds have been discovered or rediscovered by our program, DISCOVERER, which implements the algorithm in Maple.

  18. Strategic Sustainability Performance Plan. Discovering Sustainable Solutions to Power and Secure America’s Future

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2010-09-01

    Sustainability is fundamental to the Department of Energy’s research mission and operations as reflected in the Department’s Strategic Plan. Our overarching mission is to discover the solutions to power and secure America’s future.

  19. Discovering Patterns in Multi-neuronal Spike Trains using the Frequent Episode Method

    CERN Document Server

    Unnikrishnan, K P; Sastry, P S

    2007-01-01

    Discovering the 'Neural Code' from multi-neuronal spike trains is an important task in neuroscience. For such an analysis, it is important to unearth interesting regularities in the spiking patterns. In this report, we present an efficient method for automatically discovering synchrony, synfire chains, and more general sequences of neuronal firings. We use the Frequent Episode Discovery framework of Laxman, Sastry, and Unnikrishnan (2005), in which the episodes are represented and recognized using finite-state automata. Many aspects of functional connectivity between neuronal populations can be inferred from the episodes. We demonstrate these using simulated multi-neuronal data from a Poisson model. We also present a method to assess the statistical significance of the discovered episodes. Since the Temporal Data Mining (TDM) methods used in this report can analyze data from hundreds and potentially thousands of neurons, we argue that this framework is appropriate for discovering the `Neural Code'.

  20. From anorthite to vesuvianite: an excursion through the minerals first discovered in Italy

    Institute of Scientific and Technical Information of China (English)

    GiovanniFerraris; MarcoCiriotti

    2003-01-01

    With regard to the number of mineral species first dis-covered in a particular country, Italy ranks fourth, being preceded only by USA, Russia and Germany. Important rock-forming minerals like analcime, anorthite, anortho-clase, antigorite, celadonite, diopside, dolomite,forsterite, humite, leucite, lime, lizardite, magnesiochlo-ritoid, magnesite, nepheline, and sepiolite are among the 240 species first discovered in Italy. Other significant first Italian findings are some important index mineralsof the UHP metamorphism (ellenbergerite, phosphoel-lenbergerite, magnesiodumortierite, and magnesiostau-rolite; second occurrence of coesite) which were discov-ered in the well-known and first reported UHP outcrop of the Dora-Màira massif Italy is also the native land of about 30 zeolites and of the two most abundant modern species: balangeroite and carlosturanite, which are rock-forming asbestos-like minerals of serpentinites in the western Alps.

  1. VLT Phase Resolved Optical Spectroscopy of the Ultra-Compact Binary HM Cnc

    CERN Document Server

    Mason, Elena; Dall'Osso, S; Stella, L; Munari, U; Marconi, G; O'Brian, K; Covino, S; Fugazza, D

    2010-01-01

    A 321.5 s modulation was discovered in 1999 in the X-ray light curve of HM Cnc. In 2001 and 2002, optical photometric and spectroscopic observations revealed that HM Cnc is a very blue object with no intrinsic absorptions but broad (FWHM 1500 km s^-1) low equivalent width emission lines (EW 1-6A), which were first identified with the HeII Pickering series. The combination of X-ray and optical observations pictures HM Cnc as a double degenerate binary hosting two white dwarfs, and possibly being the shortest orbital period binary discovered so far. The present work is aimed at studying the orbital motion of the two components by following the variations of the shape, centroid and intensity of the emission lines through the orbit. In February 2007, we carried out the first phase resolved optical spectroscopic study with the VLT/FORS2 in the High Time Resolution (HIT) mode, yielding five phase bins in the 321 s modulation. Despite the low SNR, the data show that the intensity of the three most prominent emission...

  2. Resolving issues concerning Eskdalemuir geomagnetic hourly values

    Directory of Open Access Journals (Sweden)

    S. Macmillan

    2011-02-01

    Full Text Available The hourly values of the geomagnetic field from 1911 to 1931 derived from measurements made at Eskdalemuir observatory in the UK, and available online from the World Data Centre for Geomagnetism at http://www.wdc.bgs.ac.uk/, have now been corrected. Previously they were 2-point averaged and transformed from the original north, east and vertical down values in the tables in the observatory yearbooks. This paper documents the course of events from discovering the post-processing done to the data to the final resolution of the problem. As it was through the development of a new index, the Inter-Hour Variability index, that this post-processing came to light, we provide a revised series of this index for Eskdalemuir and compare it with that from another European observatory. Conclusions of studies concerning long-term magnetic field variability and inferred solar variability, whilst not necessarily consistent with one another, are not obviously invalidated by the incorrect hourly values from Eskdalemuir. This series of events illustrates the challenges that lie ahead in removing any remaining errors and inconsistencies in the data holdings of different World Data Centres.

  3. Resolving the inner disk of UX Orionis

    Science.gov (United States)

    Kreplin, A.; Madlener, D.; Chen, L.; Weigelt, G.; Kraus, S.; Grinin, V.; Tambovtseva, L.; Kishimoto, M.

    2016-05-01

    Aims: The cause of the UX Ori variability in some Herbig Ae/Be stars is still a matter of debate. Detailed studies of the circumstellar environment of UX Ori objects (UXORs) are required to test the hypothesis that the observed drop in photometry might be related to obscuration events. Methods: Using near- and mid-infrared interferometric AMBER and MIDI observations, we resolved the inner circumstellar disk region around UX Ori. Results: We fitted the K-, H-, and N-band visibilities and the spectral energy distribution (SED) of UX Ori with geometric and parametric disk models. The best-fit K-band geometric model consists of an inclined ring and a halo component. We obtained a ring-fit radius of 0.45 ± 0.07 AU (at a distance of 460 pc), an inclination of 55.6 ± 2.4°, a position angle of the system axis of 127.5 ± 24.5°, and a flux contribution of the over-resolved halo component to the total near-infrared excess of 16.8 ± 4.1%. The best-fit N-band model consists of an elongated Gaussian with a HWHM ~ 5 AU of the semi-major axis and an axis ration of a/b ~ 3.4 (corresponding to an inclination of ~72°). With a parametric disk model, we fitted all near- and mid-infrared visibilities and the SED simultaneously. The model disk starts at an inner radius of 0.46 ± 0.06 AU with an inner rim temperature of 1498 ± 70 K. The disk is seen under an nearly edge-on inclination of 70 ± 5°. This supports any theories that require high-inclination angles to explain obscuration events in the line of sight to the observer, for example, in UX Ori objects where orbiting dust clouds in the disk or disk atmosphere can obscure the central star. Based on observations made with ESO telescopes at Paranal Observatory under program IDs: 090.C-0769, 074.C-0552.

  4. First-principles approach to excitons in time-resolved and angle-resolved photoemission spectra

    Science.gov (United States)

    Perfetto, E.; Sangalli, D.; Marini, A.; Stefanucci, G.

    2016-12-01

    In this work we put forward a first-principles approach and propose an accurate diagrammatic approximation to calculate the time-resolved (TR) and angle-resolved photoemission spectrum of systems with excitons. We also derive an alternative formula to the TR photocurrent which involves a single time-integral of the lesser Green's function. The diagrammatic approximation applies to the relaxed regime characterized by the presence of quasistationary excitons and vanishing polarization. The nonequilibrium self-energy diagrams are evaluated using excited Green's functions; since this is not standard, the analytic derivation is presented in detail. The final result is an expression for the lesser Green's function in terms of quantities that can all be calculated in a first-principles manner. The validity of the proposed theory is illustrated in a one-dimensional model system with a direct gap. We discuss possible scenarios and highlight some universal features of the exciton peaks. Our results indicate that the exciton dispersion can be observed in TR and angle-resolved photoemission.

  5. PTF1 J191905.19+481506.2—A partially eclipsing AM CVn system discovered in the Palomar transient factory

    Energy Technology Data Exchange (ETDEWEB)

    Levitan, David; Groot, Paul J.; Prince, Thomas A.; Kulkarni, Shrinivas R.; Hallinan, Gregg; Harding, Leon K.; Sesar, Branimir [Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Kupfer, Thomas [Department of Astrophysics/IMAPP, Radboud University Nijmegen, P.O. Box 9010, NL-6500 GL Nijmegen (Netherlands); Margon, Bruce [Department of Astronomy and Astrophysics, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Kyne, Gillian [Centre for Astronomy, School of Physics, National University of Ireland, Galway (Ireland); Laher, Russ; Surace, Jason [Spitzer Science Center, MS 314-6, California Institute of Technology, Pasadena, CA 91125 (United States); Ofek, Eran O. [Benoziyo Center for Astrophysics, Faculty of Physics, Weizmann Institute of Science, Rehovot 76100 (Israel); Rutten, René G. M. [GRANTECAN S.A. Cuesta de San José, s/n, E-38712 Breña Baja, La Palma (Spain)

    2014-04-20

    We report on PTF1 J191905.19+481506.2, a newly discovered, partially eclipsing, outbursting AM CVn system found in the Palomar Transient Factory synoptic survey. This is only the second known eclipsing AM CVn system. We use high-speed photometric observations and phase-resolved spectroscopy to establish an orbital period of 22.4559(3) minutes. We also present a long-term light curve and report on the normal and super-outbursts regularly seen in this system, including a super-outburst recurrence time of 36.8(4) days. We use the presence of the eclipse to place upper and lower limits on the inclination of the system and discuss the number of known eclipsing AM CVn systems versus what would be expected.

  6. Feature-based attention resolves depth ambiguity.

    Science.gov (United States)

    Yu, D; Levinthal, B; Franconeri, S L

    2016-09-07

    Perceiving the world around us requires that we resolve ambiguity. This process is often studied in the lab using ambiguous figures whose structures can be interpreted in multiple ways. One class of figures contains ambiguity in its depth relations, such that either of two surfaces could be seen as being the "front" of an object. Previous research suggests that selectively attending to a given location on such objects can bias the perception of that region as the front. This study asks whether selectively attending to a distributed feature can also bias that region toward the front. Participants viewed a structure-from-motion display of a rotating cylinder that could be perceived as rotating clockwise or counterclockwise (as imagined viewing from the top), depending on whether a set of red or green moving dots were seen as being in the front. A secondary task encouraged observers to globally attend to either red or green. Results from both Experiment 1 and 2 showed that the dots on the cylinder that shared the attended feature, and its corresponding surface, were more likely to be seen as being in the front, as measured by participants' clockwise versus counterclockwise percept reports. Feature-based attention, like location-based attention, is capable of biasing competition among potential interpretations of figures with ambiguous structure in depth.

  7. Resolving the formation of modern Chladni figures

    Science.gov (United States)

    Tuan, P. H.; Tung, J. C.; Liang, H. C.; Chiang, P. Y.; Huang, K. F.; Chen, Y. F.

    2015-09-01

    The resonant spectrum of a thin plate driven with a mechanical oscillator is precisely measured to distinguish modern Chladni figures (CFs) observed at the resonant frequencies from classical CFs observed at the non-resonant frequencies. Experimental results reveal that modern CFs generally display an important characteristic of avoided crossings of nodal lines, whereas the nodal lines of classical CFs form a regular grid. The formation of modern CFs and the resonant frequency spectrum are resolved with a theoretical model that characterizes the interaction between the plate and the driving source into the inhomogeneous Kirchhoff-Love equation. The derived formula for determining resonant frequencies is shown to be exactly identical to the meromorphic function given in singular billiards that deals with the coupling strength on the transition between integrable and chaotic features. The good agreement between experimental results and theoretical predictions verifies the significant role of the strong-coupling effect in the formation of modern CFs. More importantly, it is confirmed that the apparatus for generating modern CFs can be developed to serve as an expedient system for exploring the nodal domains of chaotic wave functions as well as the physics of the strong coupling with a point scatterer.

  8. Resolved Multifrequency Radio Observations of GG Tau

    CERN Document Server

    Andrews, Sean M; Isella, Andrea; Birnstiel, Tilman; Rosenfeld, Katherine A; Wilner, David J; Perez, Laura M; Ricci, Luca; Carpenter, John M; Calvet, Nuria; Corder, Stuartt A; Deller, Adam T; Dullemond, Cornelis P; Greaves, Jane S; Harris, Robert J; Henning, Thomas; Kwon, Woojin; Lazio, Joseph; Linz, Hendrik; Mundy, Lee G; Sargent, Anneila I; Storm, Shaye; Testi, Leonardo

    2014-01-01

    We present sub-arcsecond resolution observations of continuum emission associated with the GG Tau quadruple star system at wavelengths of 1.3, 2.8, 7.3, and 50 mm. These data confirm that the GG Tau A binary is encircled by a circumbinary ring at a radius of 235 AU with a FWHM width of ~60 AU. We find no clear evidence for a radial gradient in the spectral shape of the ring, suggesting that the particle size distribution is spatially homogeneous on angular scales of ~0.1". A central point source, likely associated with the primary component (GG Tau Aa), exhibits a composite spectrum from dust and free-free emission. Faint emission at 7.3 mm is observed toward the low-mass star GG Tau Ba, although its origin remains uncertain. Using these measurements of the resolved, multifrequency emission structure of the GG Tau A system, models of the far-infrared to radio spectrum are developed to place constraints on the grain size distribution and dust mass in the circumbinary ring. The non-negligible curvature present ...

  9. Comparing and Aggregating Partially Resolved Trees

    CERN Document Server

    Bansal, Mukul S; Fernández-Baca, David

    2009-01-01

    We define, analyze, and give efficient algorithms for two kinds of distance measures for rooted and unrooted phylogenies. For rooted trees, our measures are based on the topologies the input trees induce on triplets; that is, on three-element subsets of the set of species. For unrooted trees, the measures are based on quartets (four-element subsets). Triplet and quartet-based distances provide a robust and fine-grained measure of the similarities between trees. The distinguishing feature of our distance measures relative to traditional quartet and triplet distances is their ability to deal cleanly with the presence of unresolved nodes, also called polytomies. For rooted trees, these are nodes with more than two children; for unrooted trees, they are nodes of degree greater than three. Our first class of measures are parametric distances, where there is a parameter that weighs the difference between an unresolved triplet/quartet topology and a resolved one. Our second class of measures are based on Hausdorff d...

  10. Angle resolved photoemission spectroscopy and surface states

    Science.gov (United States)

    Kar, Nikhiles

    2016-10-01

    Angle Resolved Photo Emission Spectroscopy (ARPES) has been a very effective tool to study the electronic states of solids, from simple metals to complex systems like cuprate superconductors. For photon energy in the range of 10 - 100 eV, it is a surface sensitive process as the free path of the photo emitted electrons is of the order of a few lattice parameters. However to interpret the experimental data one needs to have a theoretical foundation for the photoemission process. From the theory of photoemission it may be seen that one can get information about the state from which the electron has been excited. As the translational periodicity is broken normal to the surface, a new type of electron state in the forbidden energy gap can exist localized in the surface region. ARPES can reveal the existence and the property of such surface states. We shall also discuss briefly how the electromagnetic field of the photons are influenced by the presence of the surface and how one can try to take that into account in photoemission theory.

  11. Spatially resolved elemental distributions in articular cartilage

    Science.gov (United States)

    Reinert, T.; Reibetanz, U.; Vogt, J.; Butz, T.; Werner, A.; Gründer, W.

    2001-07-01

    In this study, the nuclear microprobe technique is employed to analyse the chemistry of joint cartilage in order to correlate internal structures of the collagen network with the elemental distribution. The samples were taken from pig's knee joint. 30 μm thick coronar cross-sections were prepared by means of cryosectioning and freeze-drying. We performed simultaneously particle induced X-ray emission (PIXE), Rutherford backscattering spectrometry (RBS) and elastic recoil detection analysis (ERDA). Thus we obtained spatially resolved distributions of the elements H, C, N, O, P, S, Cl, K and Ca. The main components of the organic matrix are H, C, N and O. It was shown that their relations vary with the cartilage structures. It could be shown that zones with aligned collagen fibrils contain less sulphur and potassium but more chlorine. The higher chlorine concentration is remarkable because newest biochemical studies found that hypochloric acid is involved in cartilage degradation. Furthermore, the calcium distribution is still of great interest. Its correlation to structural changes inside the cartilage is still being discussed. It could be disproved that zones of higher calcium concentration are related to the aligned structures of the collagen network.

  12. The Resolved Stellar Population of Leo A

    Science.gov (United States)

    Tolstoy, Eline

    1996-05-01

    New observations of the resolved stellar population of the extremely metal-poor Magellanic dwarf irregular galaxy Leo A in Thuan-Gunn r, g, i, and narrowband Hα filters are presented. Using the recent Cepheid variable star distance determination to Leo A by Hoessel et al., we are able to create an accurate color-magnitude diagram (CMD). We have used the Bavesian inference method described by Tolstoy & Saha to calculate the likelihood of a Monte Carlo simulation of the stellar population of Leo A being a good match to the data within the well understood errors in the data. The magnitude limits on our data are sensitive enough to look back at ~1 Gyr of star formation history at the distance of Leo A. To explain the observed ratio of red to blue stars in the observed CMD, it is necessary to invoke either a steadily decreasing star formation rate toward the present time or gaps in the star formation history. We also compare the properties of the observed stellar population with the known spatial distribution of the H I gas and H II regions to support the conclusions from CMD modeling. We consider the possibility that currently there is a period of diminished star formation in Leo A, as evidenced by the lack of very young stars in the CMD and the faint H II regions. How the chaotic H I distribution, with no observable rotation, fits into our picture of the evolution of Leo A is as yet unclear.

  13. Discovering Technicolor

    CERN Document Server

    Andersen, J R; Azuelos, G; Del Debbio, L; Del Nobile, E; Di Chiara, S; Hapola, T; Jarvinen, M; Lowdon, P J; Maravin, Y; Masina, I; Nardecchia, M; Pica, C; Sannino, F

    2011-01-01

    We provide a pedagogical introduction to extensions of the Standard Model in which the Higgs is composite. These extensions are known as models of dynamical electroweak symmetry breaking or, in brief, Technicolor. Material covered includes: motivations for Technicolor, the construction of underlying gauge theories leading to minimal models of Technicolor, the comparison with electroweak precision data, the low energy effective theory, the spectrum of the states common to most of the Technicolor models, the decays of the composite particles and the experimental signals at the Large Hadron Collider. The level of the presentation is aimed at readers familiar with the Standard Model but who have little or no prior exposure to Technicolor. Several extensions of the Standard Model featuring a composite Higgs can be reduced to the effective Lagrangian introduced in the text. We establish the relevant experimental benchmarks for Vanilla, Running, Walking, and Custodial Technicolor, and a natural fourth family of lept...

  14. Discovering Ningxia

    Institute of Scientific and Technical Information of China (English)

    HU YUE

    2010-01-01

    @@ Crystal rivers, blue skies and flowering woods surround this city-you probably won't believe it is Yinchuan, the capital city of the Ningxia Hui Autonomous Region in less developed northwest China. Shrugging off its former image of being a badly polluted region due to the coal mining industry, a lifeline for millions of local people for decades,the region is stunning tourists from around the globe with its natural and cultural wonders.

  15. Discovering Treewidth

    NARCIS (Netherlands)

    Bodlaender, H.L.

    2005-01-01

    Treewidth is a graph parameter with several interesting theoretical and practical applications. This survey reviews algorithmic results on determining the treewidth of a given graph, and finding a tree decomposition of small width. Both theoretical results, establishing the asymptotic computational

  16. Discovering Technicolor

    DEFF Research Database (Denmark)

    R. Andersen, J.; Antipin, O.; Azuelos, G.;

    2011-01-01

    We provide a pedagogical introduction to extensions of the Standard Model in which the Higgs is composite. These extensions are known as models of dynamical electroweak symmetry breaking or, in brief, Technicolor. Material covered includes: motivations for Technicolor, the construction of underly...

  17. Discovering Mozart.

    Science.gov (United States)

    Rusk, Nicole

    2010-06-01

    High-throughput imaging of genome-wide RNA interference screens and systematic analysis of protein complexes involved in mitosis yield valuable resources and reveal new subunits of well-characterized complexes.

  18. The role of refinery flaring events and bay breezes on a high surface ozone episode during the Houston, Texas DISCOVER-AQ field campaign

    Science.gov (United States)

    Loughner, C.; Follette-Cook, M. B.; Fried, A.; Pickering, K. E.

    2015-12-01

    The highest observed surface ozone concentrations in the Houston metropolitan area in 2013 occurred on September 25, which coincided with the Texas DISCOVER-AQ (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality) field campaign. Surface ozone was elevated throughout the Houston metropolitan area with maximum 8-hour average ozone peaking along the western shore of Galveston Bay, reaching 124 ppbv, almost 50 ppbv above the current EPA standard of 75 ppbv. The NASA P-3B aircraft observed plumes from refinery flares west and northwest of Galveston Bay that were transported over the water. Continental air pollution from the north was transported into the Houston metropolitan area where it mixed with locally generated emissions. A bay breeze circulation formed causing pollutants that were transported out over the water in the morning to recirculate back inland where they mixed with freshly emitted pollution near the bay breeze convergence zone. The highest surface ozone concentrations were reported near the bay breeze front. This ozone episode will be presented using measurements made during the DISCOVER-AQ field campaign and a CMAQ model simulation with integrated source apportionment, which tracks the contribution of emissions source groups and regions on ozone concentrations.

  19. The role of bay breezes and regional transport on a high surface ozone episode during the Houston, Texas DISCOVER-AQ field campaign

    Science.gov (United States)

    Loughner, C.; Follette-Cook, M. B.; Pickering, K. E.; Estes, M. J.

    2014-12-01

    The highest observed surface ozone concentrations in the Houston metropolitan area in 2013 occurred on September 25, which coincided with the Texas DISCOVER-AQ (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality) field campaign. Surface ozone was elevated throughout the Houston metropolitan area. Maximum 8-hour average ozone peaked along the western shore of Galveston Bay, reaching 124 ppbv, almost 50 ppbv above the current EPA standard of 75 ppbv, at La Porte Sylvan Beach. Continental air pollution from the north and northeast was transported into the Houston metropolitan area where it mixed with locally generated emissions. A bay breeze circulation formed causing pollutants that were transported out over the water in the morning to recirculate back inland where they mixed with freshly emitted pollution near the bay breeze convergence zone. The highest surface ozone concentrations were reported near the bay breeze front at La Porte Sylvan Beach. This ozone episode will be presented using measurements made during the DISCOVER-AQ field campaign and WRF and CMAQ model simulations.

  20. Mode resolved density of atmospheric aerosol particles

    Directory of Open Access Journals (Sweden)

    P. Aalto

    2008-09-01

    Full Text Available In this study, we investigate the mode resolved density of ultrafine atmospheric particles measured in boreal forest environment. The method used here enables us to find the distinct density information for each mode in atmospheric fine particle population: the density values for nucleation, Aitken, and accumulation mode particles are presented. The experimental data was gained during 2 May 2005–19 May 2005 at the boreal forest measurement station "SMEAR II" in Hyytiälä, Southern Finland. The density values for accumulation mode varied from 1.1 to 2 g/cm3 (average 1.5 g/cm3 and for Aitken mode from 0.4 to 2 g/cm3 (average 0.97 g/cm3. As an overall trend during the two weeks campaign, the density value of Aitken mode was seen to gradually increase. With the present method, the time dependent behaviour of the particle density can be investigated in the time scale of 10 min. This allows us to follow the density evolution of the nucleation mode particles during the particle growth process following the nucleation burst. The density of nucleation mode particles decreased during the growth process. The density values for 15 nm particles were 1.2–1.5 g/cm3 and for grown 30 nm particles 0.5–1 g/cm3. These values are consistent with the present knowledge that the condensing species are semi-volatile organics, emitted from the boreal forest.

  1. [Badly resolved triad: sexuality, contraception and pregnancy].

    Science.gov (United States)

    Oliane, A H

    1993-09-01

    Sexuality, contraception, and pregnancy are inseparable, yet they are a taboo subject both for the whole country and for adolescents. The ever-earlier awakening of sexuality requires educational mechanisms that assign fundamental importance to the implementation of social, psychological, and cultural protection strategies. The resolution of pregnancy is dependent on income just as maternity is secondary to financial independence. The majority of rich adolescents get an abortion, while poor adolescents carry to term their undesired pregnancies. Adolescence is a phase of confusion with peculiar psychosocial and cultural aspects. In the low-income population the start of formal education is precarious and delayed, an important factor in the discrepancies between well-to-do and poor social classes. Pregnancy and abortion rates vary according to economic conditions, however, their resolution clearly shows ethical, religious, and moral subjectivity. The media, rural exodus, increasing urbanization, and the economic crisis make maternity a less dominant aspect of women's lives. Young people do not obtain the necessary information for safeguarding their fertility because of the lack of specialized services, thus they are uncertain about what the health care system can provide. Much opportunity is lost because professionals are too busy or too disinterested to listen to these alienated youngsters. Preconceived notions, disinformation, and uncertainty coupled with emotional obstacles and noncooperation of the partner result in the use of contraceptives becoming a complex and difficult problem to resolve. It is necessary to alter our perceptions of adolescent sexual development. In Brazil, where more than half of the population is young, it is indispensable to devise collective programs not restricted to conventional medical practices to reach all adolescents.

  2. Deciding to Change OpenURL Link Resolvers

    Science.gov (United States)

    Johnson, Megan; Leonard, Andrea; Wiswell, John

    2015-01-01

    This article will be of interest to librarians, particularly those in consortia that are evaluating OpenURL link resolvers. This case study contrasts WebBridge (an Innovative Interface product) and LinkSource (EBSCO's product). This study assisted us in the decision-making process of choosing an OpenURL link resolver that was sustainable to…

  3. 48 CFR 2429.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Resolving tax problems. 2429.101 Section 2429.101 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS TAXES General 2429.101 Resolving tax problems. In order to...

  4. 48 CFR 29.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Resolving tax problems. 29.101 Section 29.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES General 29.101 Resolving tax problems. (a) Contract tax problems...

  5. 48 CFR 1329.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Resolving tax problems. 1329.101 Section 1329.101 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS TAXES General 1329.101 Resolving tax problems. Legal questions relating to tax...

  6. 48 CFR 229.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Resolving tax problems. 229.101 Section 229.101 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES General 229.101 Resolving tax problems....

  7. 48 CFR 629.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Resolving tax problems. 629.101 Section 629.101 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS TAXES General 629.101 Resolving tax problems. In certain instances, acquisitions by posts...

  8. 48 CFR 2929.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Resolving tax problems. 2929.101 Section 2929.101 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS TAXES General 2929.101 Resolving tax problems. Contract tax problems or...

  9. On the generalized resolvents of isometric operators with gaps

    CERN Document Server

    Zagorodnyuk, Sergey M

    2012-01-01

    In this paper we obtain some slight correction and generalization of the results of Ryabtseva on the generalized resolvents for isometric operators with a gap in their spectrum. Also, analogs of some McKelvey's results and a short proof of Inin's formula for the generalized resolvents of an isometric operator are obtained.

  10. Five New Outbursting AM CVn Systems Discovered by the Palomar Transient Factory

    CERN Document Server

    Levitan, David; Groot, Paul J; Kulkarni, Shrinivas R; Prince, Thomas A; Simonian, Gregory V; Arcavi, Iair; Bloom, Joshua S; Laher, Russ; Nugent, Peter E; Ofek, Eran O; Sesar, Branimir; Surace, Jason

    2012-01-01

    We present five new outbursting AM CVn systems and one candidate discovered as part of an ongoing search for such systems using the Palomar Transient Factory (PTF). This is the first large-area, systematic search for AM CVn systems using only large-amplitude photometric variability to select candidates. Three of the confirmed systems and the candidate system were discovered as part of the PTF transient search. Two systems were found as part of a search for outbursts through the PTF photometric database. We discuss the observed characteristics of each of these systems, including the orbital periods of two systems. We also consider the position of these systems, selected in a colour-independent survey, in colour-colour space and compare to systems selected solely by their colours. We find that the colours of our newly discovered systems do not differ significantly from those of previously known systems, but significant errors preclude a definitive answer.

  11. New Variable Stars Discovered as By-product of the Beijing Astronomical Observatory Supernova Survey

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Beijing Astronomical Observatory (BAO) 0.6 m telescope has been used for nearby supernova survey in more than 3000 fields, covering a total area of 235 deg2. More than 260 000 CCD images have been collected since April 1996, with 45 supernovae discovered. We searched for variables in about 90 000 images taken during 1996-1998. For the fields in which long period variables (LPVs) were discovered, we reduced further images taken from 1999 to 2000, for the period estimation.Among the 280 000 stars selected from the survey fields, i.e., brighter than 18 mag,we discovered seven new LPVs and reconfirmed three known LPVs. Additionally,we found 146 variable star candidates, and reconfirmed about 20 previously known or suspected objects.

  12. Starlight detectives how astronomers, inventors, and eccentrics discovered the modern universe

    CERN Document Server

    Hirshfeld, Alan

    2014-01-01

    NBC News “Top Science and Tech Books of the Year" selectionScientific American/FSG “Favorite Science Books of the Year" selectionNature.com “Top Reads of the Year" selectionKirkus Reviews “Best Books of the Year" selectionDiscover magazine “Top 5 Summer Read"“A masterful balance of science, history and rich narrative." —Discover magazine“Hirshfeld tells this climactic discovery of the expanding universe with great verve and sweep, as befits a story whose scope, characters and import leave

  13. PubMed on Tap: discovering design principles for online information delivery to handheld computers.

    Science.gov (United States)

    Hauser, Susan E; Demner-Fushman, Dina; Ford, Glenn; Thoma, George R

    2004-01-01

    Online access to biomedical information from handheld computers will be a valuable adjunct to other popular medical applications if information delivery systems are designed with handheld computers in mind. The goal of this project is to discover design principles to facilitate practitioners' access to online medical information at the point-of-care. A prototype system was developed to serve as a testbed for this research. Using the testbed, an initial evaluation has yielded several user interface design principles. Continued research is expected to discover additional user interface design principles as well as guidelines for results organization and system performance

  14. PROSPECTS FOR MEASURING THE MASS OF BLACK HOLES AT HIGH REDSHIFTS WITH RESOLVED KINEMATICS USING GRAVITATIONAL LENSING

    Energy Technology Data Exchange (ETDEWEB)

    Hezaveh, Yashar D. [Kavli Institute for Particle Astrophysics and Cosmology Stanford University, Stanford, CA (United States)

    2014-08-20

    Application of the most robust method of measuring black hole masses, spatially resolved kinematics of gas and stars, is presently limited to nearby galaxies. The Atacama Large Millimeter/sub-millimeter Array (ALMA) and 30m class telescopes (the Thirty Meter Telescope, the Giant Magellan Telescope, and the European Extremely Large Telescope) with milli-arcsecond resolution are expected to extend such measurements to larger distances. Here, we study the possibility of exploiting the angular magnification provided by strong gravitational lensing to measure black hole masses at high redshifts (z ∼ 1-6), using resolved gas kinematics with these instruments. We show that in ∼15% and ∼20% of strongly lensed galaxies, the inner 25 and 50 pc could be resolved, allowing the mass of ≳ 10{sup 8} M {sub ☉} black holes to be dynamically measured with ALMA, if moderately bright molecular gas is present at these small radii. Given the large number of strong lenses discovered in current millimeter surveys and future optical surveys, this fraction could constitute a statistically significant population for studying the evolution of the M-σ relation at high redshifts.

  15. Prospects for Measuring the Mass of Black Holes at High Redshifts with Resolved Kinematics Using Gravitational Lensing

    CERN Document Server

    Hezaveh, Yashar D

    2014-01-01

    Application of the most robust method of measuring black hole masses, spatially resolved kinematics of gas and stars, is presently limited to nearby galaxies. The Atacama Large Millimeter/sub-millimeter Array (ALMA) and thirty meter class telescopes (the Thirty Meter Telescope, the Giant Magellan Telescope, and the European Extremely Large Telescope) with milli-arcsecond resolution are expected to extend such measurements to larger distances. Here, we study the possibility of exploiting the angular magnification provided by strong gravitational lensing to measure black hole masses at high redshifts (z~ 1-6), using resolved gas kinematics with these instruments. We show that in ~15% and ~20% of strongly lensed galaxies, the inner 25 and 50 pc could be resolved, allowing the mass of ~$10^8 M_{\\odot}$ black holes to be dynamically measured with ALMA, if moderately bright molecular gas is present at these small radii. Given the large number of strong lenses discovered in current millimeter surveys and future opti...

  16. Characteristic of gravity waves resolved in ECMWF

    Science.gov (United States)

    Preusse, Peter; Eckermann, Stephen; Ern, Manfred; Riese, Martin

    Gravity waves (GWs) influence the circulation of the atmosphere on global scale. Because of insufficient measurements and the difficulty to involve all relevant scales in a single model run, they are one of the chief uncertainties in climate and weather prediction. More information, in particular on global scale, is required. Can we employ global models such as the ECMWF high-resolution GCM to infer quantities of resolved GWs? Does this give us insight for the characteristics and relative importance of real GW sources? And can we use such data safely for, e.g., planning measurement campaigns on GWs? Also trajectory studies of cloud formation (cirrus in the UTLS, PSCs) and related dehydration and denitrification rely heavily on realistic temperature structures due to GWs. We here apply techniques developed for an ESA study proving the scientifc break-through which could be reached by a novel infrared limb imager. The 3D temperature structure of mesoscale GWs is exploited to determine amplitudes and 3D wave vectors of GWs at different levels (25km, 35km and 45km altitude) in the stratosphere. Similar to real observations, GW momentum flux is largest in the winter polar vortex and exhibits a second maximum in the summer subtropics. Based on the 3D wavevectors backward ray-tracing is employed to characterize specific sources. For instance, we find for the northern winter strong GW momentum flux (GWMF) associated with mountain waves from Norway and Greenland as well as waves emitted in the lower troposphere from a storm approaching Norway. Waves from these sources spread up to several thousand km in the stratosphere. Together these three events form a burst in the total hemispheric GWMF of a factor of 3. Strong mountain wave events are also found e.g. at Tierra del Fuego and the Antarctic Peninsula, regions which are in the focus of observational and modeling studies for a decade. Gravity waves in the tropical region are associated with deep convection in the upper

  17. An analytic approach to resolving problems in medical ethics.

    Science.gov (United States)

    Candee, D; Puka, B

    1984-06-01

    Education in ethics among practising professionals should provide a systematic procedure for resolving moral problems. A method for such decision-making is outlined using the two classical orientations in moral philosophy, teleology and deontology. Teleological views such as utilitarianism resolve moral dilemmas by calculating the excess of good over harm expected to be produced by each feasible alternative for action. The deontological view focuses on rights, duties, and principles of justice. Both methods are used to resolve the 1971 Johns Hopkins case of a baby born with Down's syndrome and duodenal atresia.

  18. Exploring National Parks & Monuments: Students Can Discover National Monuments, National Parks & Natural Wonders

    Science.gov (United States)

    Curriculum Review, 2009

    2009-01-01

    This article presents an interview with Cynthia Light Brown, author of "Discover National Monuments, National Parks: Natural Wonders," a book that introduces readers ages 8-12 to the history and science behind some of the amazing natural sites in the United States. In this interview, Cynthia Light Brown describes how she became interested in…

  19. John Ellis, theoretical physicists: Are we close to discovering the Higgs Boson?

    CERN Multimedia

    CERN Video Productions; Silvano de Gennaro

    2012-01-01

    John Ellis, theoretical physicists, answers the question "Are we close to discovering the Higgs Boson and why is it so difficult to find it?" in preparation of the Press Conference following the scientific seminar announcing results of the searches for the Higgs boson on July 4 2012.

  20. First records of Nocomis biguttatus (Hornyhead Chub) from West Virginia discovered in museum voucher specimens

    Science.gov (United States)

    Welsh, Stuart; Cincotta, Daniel A.; Starnes, Wayne C.

    2013-01-01

    Specimens of Nocomis biguttatus (Hornyhead Chub) from South Fork Hughes River (Little Kanawha River drainage, WV) were discovered in two museum lots at the North Carolina Museum of Natural Sciences. These accessions, collected in 1960 and 1966, represent an addition to the state fauna and are the first distribution records for this species from the Appalachian Plateau, WV

  1. Discovering Inexpensive, Effective Catalysts for Solar Energy Conversion: An Authentic Research Laboratory Experience

    Science.gov (United States)

    Shaner, Sarah E.; Hooker, Paul D.; Nickel, Anne-Marie; Leichtfuss, Amanda R.; Adams, Carissa S.; de la Cerda, Dionisia; She, Yuqi; Gerken, James B.; Pokhrel, Ravi; Ambrose, Nicholas J.; Khaliqi, David; Stahl, Shannon S.; Schuttlefield Christus, Jennifer D.

    2016-01-01

    Electrochemical water oxidation is a major focus of solar energy conversion efforts. A new laboratory experiment has been developed that utilizes real-time, hands-on research to discover catalysts for solar energy conversion. The HARPOON, or Heterogeneous Anodes Rapidly Perused for Oxygen Overpotential Neutralization, experiment allows an array of…

  2. Using Appreciative Inquiry to Discover and Deliver Change for Surgical Technology Students

    Science.gov (United States)

    Cabai, Katherine A.

    2012-01-01

    The purpose of this study was to examine efficacious teaching-learning strategies that community college stakeholders employ that enhance surgical technology student outcomes. Knowles's adult learning theory, constructivist theory, and appreciative inquiry served as the theoretical foundation for this study. Discovering effective aspects and…

  3. Discovering Valuable Growth Opportunities: An Analysis of Equity Alliances with IPO Firms

    NARCIS (Netherlands)

    J.J. Reuer (Jeffrey); T.W. Tong (Tony)

    2010-01-01

    textabstractFirms often use alliances to access external resources and explore new market or technological opportunities, yet they also can face obstacles to discovering these opportunities in the first place. In this paper, we examine how firms can overcome these obstacles and form equity alliances

  4. Examining Pre-K Professional Development Programs: Discovering the Road to Exceptional Instructional Practices

    Science.gov (United States)

    Williams, Sheila D.

    2016-01-01

    The purpose of this qualitative research study was to discover and interpret the experiences of pre-k teachers in an urban school district located in a Northeastern region of the United States. Using a basic qualitative research design, fifteen participants were recruited by a purposeful sampling method to be interviewed after the implementation…

  5. "Discovering the Cell": An Educational Game about Cell and Molecular Biology

    Science.gov (United States)

    Spiegel, Carolina N.; Alves, Gutemberg G.; Cardona, Tania da S.; Melim, Leandra M. C.; Luz, Mauricio R. M. P.; Araujo-Jorge, Tania C.; Henriques-Pons, Andrea

    2008-01-01

    The role of games within education becomes clearer as students become more active and are able to take decisions, solve problems and react to the results of those decisions. The educational board game "Discovering the Cell" ("Celula Adentro"), is based on problem-solving learning. This investigative game attempts to stimulate…

  6. When Two Circles Determine a Triangle. Discovering and Proving a Geometrical Condition in a Computer Environment

    Science.gov (United States)

    Metaxas, Nikolaos; Karagiannidou, Andromachi

    2010-01-01

    Visualization of mathematical relationships enables students to formulate conjectures as well as to search for mathematical arguments to support these conjectures. In this project students are asked to discover the sufficient and necessary condition so that two circles form the circumscribed and inscribed circle of a triangle and investigate how…

  7. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils

    OpenAIRE

    Trulove, Susan

    2005-01-01

    Researchers from China and the United States have found evidence of lichen-like symbiosis in 600-million-year-old fossils from South China. The previous earliest evidence of lichen was 400-million-years-old, discovered in Scotland. The discovery also adds to the scarce fossil record of fungi and raises new questions about lichen evolution.

  8. Communication between the right and circumflex coronary arteries discovered incidentally by multidetector computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Se Hwan; Kim, Eui Jong; Woo, Jong Shin; Kim, Soo Joong; Youn, Hyo Chul; Oh, Joo Hyeong [College of Medicine, Kyung Hee University, Seoul (Korea, Republic of)

    2016-09-15

    Intercoronary communication is a rare congenital coronary anomaly. We present a case of a 48-year-old man with an incidentally discovered communication between the right and circumflex coronary arteries, who was admitted with chest tightness and exertional dyspnea. The initial diagnosis was made using electrocardiogram-gated multidetector computed tomography.

  9. VizieR Online Data Catalog: newly discovered planets from WASP-South (Turner+, 2016)

    Science.gov (United States)

    Turner, O. D.; Anderson, D. R.; Cameron, A. Collier; Delrez, L.; Evans, D. F.; Gillon, M.; Hellier, C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Segransan, D.; Smalley, B.; Smith, A. M. S.; Triaud, A. H. M. J.; Udry, S.; West, R. G.

    2017-02-01

    Lightcurves and radial velocity data of three newly discovered planets from the WASP-South survey. Discovery data come from the WASP-South telescope (SAAO, South Africa) with follow-up lightcurves from the TRAPPIST telescope and EulerCam on the Swiss telescope (La Silla, Chile). Radial velocity data are from the CORALIE spectrograph on the Swiss telescope. (6 data files).

  10. Review of Discovering Craven, Richard Harland Collection and Craven Museum Lithics Collections CD-Roms

    Directory of Open Access Journals (Sweden)

    Gail Falkingham

    2003-07-01

    Full Text Available Discovering Craven is aimed at the general reader, and provides a beautifully illustrated and presented interactive CD-Rom, created with Illuminatus Interactive. Craven is one of the seven districts within the county of North Yorkshire, a large area of which falls within the Yorkshire Dales National Park.

  11. Radio detection of the near-IR discovered supernova 2010P

    Science.gov (United States)

    Herrero-Illana, R.; Romero-Canizales, C.; Perez-Torres, M. A.; Alberdi, A.; Kankare, E.; Mattila, S.; Ryder, S. D.

    2012-09-01

    We report the radio detection of supernova 2010P (cf. CBETs 2145, 2149) in Arp 299 in EVLA (8459 MHz) observations from 15th Jun 2011. SN2010P was discovered in near-IR images on 18th Jan 2010, and classified as a Type Ib/IIb SN based on its optical spectrum obtained on 11th Feb 2010 (cf. CBET 2189).

  12. PS17and : a nearby, intrinsically faint transient discovered by PSST

    Science.gov (United States)

    Smith, K. W.; Wright, D.; Smartt, S. J.; Young, D. R.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.; Foley, R. J.; Kilpatrick, C.

    2017-02-01

    We report the discovery of the following nearby transient as part of the Pan-STARRS Survey for Transients (PSST). Information on all objects discovered by the Pan-STARRS Survey for Transients is available at http://star.pst.qub.ac.uk/ps1threepi/ (see Chambers et al. arXiv:1612.05560, Huber et al. ATel #7153).

  13. Protocols for Teaching Students How to Search for, Discover, and Evaluate Innovations

    Science.gov (United States)

    Norton, William I., Jr.; Hale, Dena H.

    2011-01-01

    The authors introduce and develop protocols to guide aspiring entrepreneurs' behaviors in searching for and discovering innovative ideas that may have commercial potential. Systematic search has emerged as a theory-based, prescriptive framework to guide innovative behavior. Grounded in Fiet's theory of search and discovery, this article provides…

  14. Jiangxi Again Discovered Worldclass Tungsten Mine with Controlled Volume Topping 1 million tonnes

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>The reporter recently learned from Jiangxi Province Geological Mineral Prospecting & Development Bureau that following the discovery of ultra large tungsten mine in northwestern Jiangxi in 2010, Jiangxi Province again discovered a world-class large tungsten mine in Zhuxi Mining Zone in Fuliang County in northeastern Jiangxi.

  15. Final Technical Report: Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae

    Energy Technology Data Exchange (ETDEWEB)

    Saurabh W. Jha

    2012-10-03

    The final technical report from the project "Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae" led at Rutgers the State University of New Jersey by Prof. Saurabh W. Jha is presented, including all publications resulting from this award.

  16. SWeMoF: A semantic framework to discover patterns in learning networks

    NARCIS (Netherlands)

    Kalz, Marco; Beekman, Niels; Karsten, Anton; Oudshoorn, Diederik; Van Rosmalen, Peter; Van Bruggen, Jan; Koper, Rob

    2009-01-01

    Kalz, M., Beekman, N., Karsten, A., Oudshoorn, D., Van Rosmalen, P., Van Bruggen, J., & Koper, R. (2009). SWeMoF: A semantic framework to discover patterns in learning networks. In U. Cress, V. Dimitrova & M. Specht (Eds.), Learning in the Synergy of Multiple Disciplines. Proceedings of the Fourth E

  17. Triangle orientation discrimination: the alternative to minimum resolvable temperature difference and minimum resolvable contrast

    Science.gov (United States)

    Bijl, Piet; Valeton, J. Mathieu

    1998-07-01

    The characterization of electro-optical system performance by means of the minimum resolvable temperature difference (MRTD) or the minimum resolvable contrast (MRC) has at least three serious disadvantages: (1) the bar pattern stimulus is theoretically and practically unsuitable for 1D or 2D spatially sampled systems such as pixel-array cameras, (2) spatial phase is not taken into account, and (3) the results depend on the observer's subjective decision criterion. We propose an adequate and easily applicable alternative: the triangle orientation discrimination (TOD) threshold. The TOD is based on an improved test pattern, a better defined observer task, and a solid psychophysical measurement procedure. The method has a large number of theoretical and practical advantages: it is suitable for pixel-array cameras, scanning systems and other electro-optical and optical imaging system sin both the thermal and visual domains, it has a close relationship to real target acquisition, and the observer task is easy. The results are free from observer bias and allow statistical significance tests. The method lends itself very well to automatic measurements, and can be extended for future sensor systems that include advanced image processing. The TOD curve can be implemented easily in a target acquisition (TA) model such as ACQUIRE. An observer performance study with real targets shows that the TOD curve better predicts TA performance than the mRC does. The method has been implemented successfully in a thermal imager field test apparatus called the thermal imager performance indicator and may be implemented in current MRTD test equipment with little effort.

  18. NASA Chandra X-ray Observatory Selected as Editor's Choice in 2000 Discover Magazine Awards for Technological Innovation

    Science.gov (United States)

    2000-06-01

    laureate Subrahmanyan Chandrasekhar, was launched in July 1999 aboard the Space Shuttle Columbia and deployed to a highly elliptical Earth orbit. Over the next five years, it will use the world's most powerful X-ray telescope to probe the mysteries of a universe that cannot be seen by the human eye or conventional optical telescopes. Its array of exquisite mirrors, ground and polished by Raytheon Optical Systems, Inc., and assembled and aligned by Eastman Kodak, will allow Chandra to gather and focus X-rays from celestial sources billions of light years away. Chandra's science instrument module was designed and built by Ball Aerospace & Technologies Corp., then integrated with instruments provided by the Smithsonian Astrophysical Observatory, Penn State University, Massachusetts Institute of Technology, Space Research Organization of The Netherlands, and the Max Planck Institute in Germany. Ball Aerospace also produced Chandra's aspect camera. The Discover Awards for Technological Innovation, now in their 11th year, are designed to acknowledge the creativity of men, women, corporations and institutions who have reached superior levels of ingenuity. Each year, Discover Magazine's editorial staff reviews thousands of new products and ideas presented in the scientific literature or nominated by leading technology-based companies and research organizations. The editorial staff selects semi-finalists in each of eight technology categories, then submits the nominations to an independent panel of experts. The panel then selects the finalists and the winner in each area of technology. The Editor's choice category is reserved for innovations so unique or promising that they go beyond the magazine's established innovation categories by providing a marked advance in their field. Chandra's powerful X-ray telescope can resolve distant images eight times sharper and detect X-ray sources 20 times fainter than any previous X-ray space telescope. Chandra, along with the rest of the winners

  19. Time resolved fluorescence of naproxen in organogel medium

    Science.gov (United States)

    Burguete, M. Isabel; Izquierdo, M. Angeles; Galindo, Francisco; Luis, Santiago V.

    2008-07-01

    The interaction between non-steroidal anti-inflammatory drug naproxen and the self assembled fibrillar network created by a low molecular weight organogelator has been probed by means of time resolved fluorescence spectroscopy.

  20. SQL level global query resolving for web based GIS

    Science.gov (United States)

    Chen, Bin; Huang, Fengru; Huang, Zhou; Sun, Yumei; Fang, Yu

    2007-06-01

    This paper introduced a SQL level approach to resolve global spatial query in Web based heterogeneous distributed spatial database environment. The main prohibit of this SQL level approach was its widespread compatibility and standardization. Firstly, a SQL based Equivalent Distributed Program (EDP) was introduced to express distributed spatial processing transactions. Then global resource directories for virtual global view describing were discussed to organize information that resolving need. The contents of global resource directories included data storage directory, hosts directory and working status directory. With these mechanisms, relational algebra expression equivalence principles were utilized to resolve global spatial queries to EDPs. Finally, several samples were presented to show the process of resolving. This approach was suitable to all sorts of distributed computing environments either centralized such as CORBA or decentralized such as P2P computing platforms.

  1. Steady state and time resolved spectroscopy of photoswitchable systems

    NARCIS (Netherlands)

    Hou, Lili

    2013-01-01

    Steady state en time resolved spectroscopie zijn twee fundamentele methodes voor het bestuderen van fotochemische processen. In dit proefschrift zijn drie zelf-opgezette spectroscopische systemen beschreven, waarmee samen met andere spectroscopische methoden verscheidende met licht schakelbare syste

  2. Resolving brain regions using nanostructure initiator mass spectrometry imaging

    OpenAIRE

    Lee, Do Yup; Platt, Virginia; Bowen, Ben; Louie, Katherine; Canaria, Christie; McMurray, Cynthia T.; Northen, Trent

    2012-01-01

    Specific cell types are critically implicated in a variety of neuropathologies that exhibit region-specific susceptibility. Neuronal and glial function is impaired in a host of neurodegenerative diseases. Previous reports suggest that mass spectrometry imaging has the potential to resolve cell-specific enrichment in brain regions; however, individual ions cannot resolve glial and neuronal cells within the complex structure of brain tissue. Here, we utilized a matrix-free surface mass spectrom...

  3. Nonlocal Problems for Fractional Differential Equations via Resolvent Operators

    Directory of Open Access Journals (Sweden)

    Zhenbin Fan

    2013-01-01

    Full Text Available We discuss the continuity of analytic resolvent in the uniform operator topology and then obtain the compactness of Cauchy operator by means of the analytic resolvent method. Based on this result, we derive the existence of mild solutions for nonlocal fractional differential equations when the nonlocal item is assumed to be Lipschitz continuous and neither Lipschitz nor compact, respectively. An example is also given to illustrate our theory.

  4. Super-resolved imaging geometrical and diffraction approaches

    CERN Document Server

    2011-01-01

    In this brief we review several approaches that provide super resolved imaging, overcoming the geometrical limitation of the detector as well as the diffraction effects set by the F number of the imaging lens. In order to obtain the super resolved enhancement, we use spatially non-uniform and/or random transmission structures to encode the image or the aperture planes. The desired resolution enhanced images are obtained by post-processing decoding of the captured data.

  5. A spin- and angle-resolving photoelectron spectrometer

    CERN Document Server

    Berntsen, M H; Leandersson, M; Hahlin, A; hlund, J \\AA; Wannberg, B; nsson, M M\\aa; Tjernberg, O

    2010-01-01

    A new type of hemispherical electron energy analyzer that permits angle and spin resolved photoelectron spectroscopy has been developed. The analyzer permits standard angle resolved spectra to be recorded with a two-dimensional detector in parallel with spin detection using a mini-Mott polarimeter. General design considerations as well as technical solutions are discussed and test results from the Au(111) surface state are presented.

  6. A Resolved Debris Disk Around the Candidate Planet-hosting Star HD 95086

    Science.gov (United States)

    Moor, A.; Abraham, P.; Kospal, A.; Szabo, Gy. M.; Apai, D.; Balog, Z.; Csengeri, T.; Grady, C.; Henning, Th.; Juhasz, J.; Kiss, Cs.; Pasucci, I.; Szulagyi, J.; Vavrek, R.

    2013-01-01

    Recently, a new planet candidate was discovered on direct images around the young (10-17 Myr) A-type star HD 95086. The strong infrared excess of the system indicates that, similar to HR8799, Beta Pic, and Fomalhaut, the star harbors a circumstellar disk. Aiming to study the structure and gas content of the HD 95086 disk, and to investigate its possible interaction with the newly discovered planet, here we present new optical, infrared, and millimeter observations. We detected no CO emission, excluding the possibility of an evolved gaseous primordial disk. Simple blackbody modeling of the spectral energy distribution suggests the presence of two spatially separate dust belts at radial distances of 6 and 64 AU. Our resolved images obtained with the Herschel Space Observatory reveal a characteristic disk size of approx. 6.0 × 5.4 (540 × 490 AU) and disk inclination of approx 25 deg. Assuming the same inclination for the planet candidate's orbit, its reprojected radial distance from the star is 62 AU, very close to the blackbody radius of the outer cold dust ring. The structure of the planetary system at HD 95086 resembles the one around HR8799. Both systems harbor a warm inner dust belt and a broad colder outer disk and giant planet(s) between the two dusty regions. Modeling implies that the candidate planet can dynamically excite the motion of planetesimals even out to 270 AU via their secular perturbation if its orbital eccentricity is larger than about 0.4. Our analysis adds a new example to the three known systems where directly imaged planet(s) and debris disks coexist.

  7. Seventh international conference on time-resolved vibrational spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Dyer, R.B.; Martinez, M.A.D.; Shreve, A.; Woodruff, W.H. [comps.

    1997-04-01

    The International Conference on Time-Resolved Vibrational Spectroscopy (TRVS) is widely recognized as the major international forum for the discussion of advances in this rapidly growing field. The 1995 conference was the seventh in a series that began at Lake Placid, New York, 1982. Santa Fe, New Mexico, was the site of the Seventh International Conference on Time-Resolved Vibrational Spectroscopy, held from June 11 to 16, 1995. TRVS-7 was attended by 157 participants from 16 countries and 85 institutions, and research ranging across the full breadth of the field of time-resolved vibrational spectroscopy was presented. Advances in both experimental capabilities for time-resolved vibrational measurements and in theoretical descriptions of time-resolved vibrational methods continue to occur, and several sessions of the conference were devoted to discussion of these advances and the associated new directions in TRVS. Continuing the interdisciplinary tradition of the TRVS meetings, applications of time-resolved vibrational methods to problems in physics, biology, materials science, and chemistry comprised a large portion of the papers presented at the conference.

  8. Discovery and resolve: the Human Genetics Society of Australasia Oration 2011.

    Science.gov (United States)

    Pearn, John

    2011-10-01

    Human genetics spans every facet of biology from molecular science, through laboratory and clinical practice, to psychology and anthropology. In each of these areas, the history of human genetics has been punctuated by paradigm shifts in knowledge. Each such new concept has been received with skepticism, often with perplexity, and sometimes with frank incredulity. Such comprise the datum milestones along the path leading to our present corpus of genetic knowledge. In parallel to the personal threats to Copernicus and Galileo in the field of astronomy in the 17th century, almost all genetic discoveries of the 19th and 20th centuries were seen as challenges to the received wisdom, and sometimes the social order, of their time and place. Researchers, scientists and clinicians encountering such new and often-heretical paradigm shifts have required considerable resolve to promote and publish their work. Just as in the field of astronomy, new directions in genetics have threatened not only the reputations and sometimes the careers of scientists, but also have been challenges to fundamental religious and sociological beliefs in society more broadly. Examples followed the discovery of biological sexual dimorphism (in plants as well as animals) by Nehemiah Grew (1641-1712). Darwinian evolution, Mendel's First and Second Laws, the existence of mitochondrial genes, apoptosis and its genetic basis, and uniparental disomy are more recent examples. Many of these new revelations, which today have led to the current understanding of fundamental biology, were discovered by individuals working in relative isolation. To promote and publish findings that fundamentally challenge received wisdom continues to require considerable resolve, if not courage. Herein lies a message for all clinicians and researchers.

  9. Discovering Land Cover Web Map Services from the Deep Web with JavaScript Invocation Rules

    Directory of Open Access Journals (Sweden)

    Dongyang Hou

    2016-06-01

    Full Text Available Automatic discovery of isolated land cover web map services (LCWMSs can potentially help in sharing land cover data. Currently, various search engine-based and crawler-based approaches have been developed for finding services dispersed throughout the surface web. In fact, with the prevalence of geospatial web applications, a considerable number of LCWMSs are hidden in JavaScript code, which belongs to the deep web. However, discovering LCWMSs from JavaScript code remains an open challenge. This paper aims to solve this challenge by proposing a focused deep web crawler for finding more LCWMSs from deep web JavaScript code and the surface web. First, the names of a group of JavaScript links are abstracted as initial judgements. Through name matching, these judgements are utilized to judge whether or not the fetched webpages contain predefined JavaScript links that may prompt JavaScript code to invoke WMSs. Secondly, some JavaScript invocation functions and URL formats for WMS are summarized as JavaScript invocation rules from prior knowledge of how WMSs are employed and coded in JavaScript. These invocation rules are used to identify the JavaScript code for extracting candidate WMSs through rule matching. The above two operations are incorporated into a traditional focused crawling strategy situated between the tasks of fetching webpages and parsing webpages. Thirdly, LCWMSs are selected by matching services with a set of land cover keywords. Moreover, a search engine for LCWMSs is implemented that uses the focused deep web crawler to retrieve and integrate the LCWMSs it discovers. In the first experiment, eight online geospatial web applications serve as seed URLs (Uniform Resource Locators and crawling scopes; the proposed crawler addresses only the JavaScript code in these eight applications. All 32 available WMSs hidden in JavaScript code were found using the proposed crawler, while not one WMS was discovered through the focused crawler

  10. Getting to Know You: Discovering User Behaviors and Their Implications for Service Design

    Science.gov (United States)

    Daigle, Ben

    2013-01-01

    Public services librarians are often in the position of training patrons how to use technology. They adopt new technologies such as discovery layers, link resolvers, subject guides, virtual reference services, OPACs, content management systems, and institutional repositories to provide access to materials and facilitate collaboration, but…

  11. Fitting a mixture model by expectation maximization to discover motifs in biopolymers

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, T.L.; Elkan, C. [Univ. of California, La Jolla, CA (United States)

    1994-12-31

    The algorithm described in this paper discovers one or more motifs in a collection of DNA or protein sequences by using the technique of expectation maximization to fit a two-component finite mixture model to the set of sequences. Multiple motifs are found by fitting a mixture model to the data, probabilistically erasing the occurrences of the motif thus found, and repeating the process to find successive motifs. The algorithm requires only a set of unaligned sequences and a number specifying the width of the motifs as input. It returns a model of each motif and a threshold which together can be used as a Bayes-optimal classifier for searching for occurrences of the motif in other databases. The algorithm estimates how many times each motif occurs in each sequence in the dataset and outputs an alignment of the occurrences of the motif. The algorithm is capable of discovering several different motifs with differing numbers of occurrences in a single dataset.

  12. HATS-1b: THE FIRST TRANSITING PLANET DISCOVERED BY THE HATSouth SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Penev, K.; Bakos, G. A.; Hartman, J. D.; Csubry, Z. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Bayliss, D.; Zhou, G.; Conroy, P. [Australian National University, Canberra (Australia); Jordan, A.; Suc, V.; Rabus, M.; Brahm, R.; Espinoza, N. [Departamento de Astronomia y Astrofisica, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, 7820436 Macul, Santiago (Chile); Mohler, M.; Mancini, L.; Henning, T.; Nikolov, N.; Csak, B. [Max Planck Institute for Astronomy, Heidelberg (Germany); Beky, B.; Noyes, R. W. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Buchhave, L., E-mail: kpenev@astro.princeton.edu [Niels Bohr Institute, Copenhagen University (Denmark); and others

    2013-01-01

    We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V = 12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period of P Almost-Equal-To 3.4465 days, mass of M{sub p} Almost-Equal-To 1.86 M{sub J}, and radius of R{sub p} Almost-Equal-To 1.30 R{sub J}. The host star has a mass of 0.99 M{sub Sun} and radius of 1.04 R{sub Sun }. The discovery light curve of HATS-1b has near-continuous coverage over several multi-day timespans, demonstrating the power of using a global network of telescopes to discover transiting planets.

  13. Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Energy Technology Data Exchange (ETDEWEB)

    Yanagi, Yoshinobu; Asaumi, Jun-ichi E-mail: asaumi@md.okayama-u.ac.jp; Maki, Yuu; Murakami, Jun; Hisatomi, Miki; Matsuzaki, Hidenobu; Konouchi, Hironobu; Honda, Yosutoshi; Kishi, Kanji

    2003-07-01

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

  14. Discover & eXplore Neural Network (DXNN) Platform, a Modular TWEANN

    CERN Document Server

    Sher, Gene I

    2010-01-01

    In this paper I present a novel type of Topology and Weight Evolving Artificial Neural Network (TWEANN) system called Discover & eXplore Neural Network (DXNN) Platform. DXNN utilizes a modular and hierarchical topology which promotes highly scalable and dynamically granular systems to evolve. Among the novel features discussed in this paper is a simple and database friendly encoding for hierarchical/modular NNs, a new selection method aimed at producing highly compact and fit individuals within the population, and a new training phase referred to as "Tuning Phase" which is aimed at removing the need for speciation algorithms. Mutation operators aimed at improving diversity, expandability, and capabilities of the DXNN through a built in feature selection method that allows for the evolved system to expand, discover and explore new sensors and actuators is also covered. Finally, DXNN platform is then compared to other state of the art TWEANNs on a control task to demonstrate its ability to produce highly co...

  15. A Hybrid Multi Objective Particle Swarm Optimization Method to Discover Biclusters in Microarray Data

    CERN Document Server

    lashkargir, Mohsen; Dastjerdi, Ahmad Baraani

    2009-01-01

    In recent years, with the development of microarray technique, discovery of useful knowledge from microarray data has become very important. Biclustering is a very useful data mining technique for discovering genes which have similar behavior. In microarray data, several objectives have to be optimized simultaneously and often these objectives are in conflict with each other. A Multi Objective model is capable of solving such problems. Our method proposes a Hybrid algorithm which is based on the Multi Objective Particle Swarm Optimization for discovering biclusters in gene expression data. In our method, we will consider a low level of overlapping amongst the biclusters and try to cover all elements of the gene expression matrix. Experimental results in the bench mark database show a significant improvement in both overlap among biclusters and coverage of elements in the gene expression matrix.

  16. HATS-1b: The First Transiting Planet Discovered by the HATSouth Survey

    CERN Document Server

    Penev, K; Bayliss, D; Jordán, A; Mohler, M; Zhou, G; Suc, V; Rabus, M; Hartman, J D; Mancini, L; Béky, B; Csubry, Z; Buchhave, L; Henning, T; Nikolov, N; Csák, B; Brahm, R; Espinoza, N; Conroy, P; Noyes, R W; Sasselov, D D; Schmidt, B; Wright, D J; Tinney, C G; Addison, B C; Lázár, J; Papp, I; Sári, P

    2012-01-01

    We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V=12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period P~3.4465 d, mass Mp~1.86MJ, and radius Rp~1.30RJ. The host star has a mass of 0.99Msun, and radius of 1.04Rsun. The discovery light curve of HATS-1b has near continuous coverage over several multi-day periods, demonstrating the power of using a global network of telescopes to discover transiting planets.

  17. Virtual and Dynamic Hierarchical Architecture: an overlay network topology for discovering grid services with high performance

    Institute of Scientific and Technical Information of China (English)

    黄理灿; 吴朝晖; 潘云鹤

    2004-01-01

    This paper presents an overlay network topology called Virtual and Dynamic Hierarchical Architecture (VDHA) for discovering Grid services with high performance. Service discovery based on VDHA has scalable, autonomous, efficient, reliable and quick responsive. We propose two service discovery algorithms. Full Search Query and Discovery Protocol (FSQDP) discovers the nodes that match the request message from all N nodes, which has time complexity O(logN), space complexity O(nvg) (nvg being node numbers of each virtual group), and message-cost O(N), and Domain-Specific Query and Discovery Protocol (DSQDP) searches nodes in only specific domains with time complexity O(nvg), space complexity O(nvg), and message-cost O(nvg). In this paper, we also describe VDHA, its formal definition, and Grid Group Management Protocol.

  18. Spiking neurons can discover predictive features by aggregate-label learning.

    Science.gov (United States)

    Gütig, Robert

    2016-03-01

    The brain routinely discovers sensory clues that predict opportunities or dangers. However, it is unclear how neural learning processes can bridge the typically long delays between sensory clues and behavioral outcomes. Here, I introduce a learning concept, aggregate-label learning, that enables biologically plausible model neurons to solve this temporal credit assignment problem. Aggregate-label learning matches a neuron's number of output spikes to a feedback signal that is proportional to the number of clues but carries no information about their timing. Aggregate-label learning outperforms stochastic reinforcement learning at identifying predictive clues and is able to solve unsegmented speech-recognition tasks. Furthermore, it allows unsupervised neural networks to discover reoccurring constellations of sensory features even when they are widely dispersed across space and time.

  19. Concept of proton radiography using energy resolved dose measurement

    Science.gov (United States)

    Bentefour, El H.; Schnuerer, Roland; Lu, Hsiao-Ming

    2016-08-01

    Energy resolved dosimetry offers a potential path to single detector based proton imaging using scanned proton beams. This is because energy resolved dose functions encrypt the radiological depth at which the measurements are made. When a set of predetermined proton beams ‘proton imaging field’ are used to deliver a well determined dose distribution in a specific volume, then, at any given depth x of this volume, the behavior of the dose against the energies of the proton imaging field is unique and characterizes the depth x. This concept applies directly to proton therapy scanning delivery methods (pencil beam scanning and uniform scanning) and it can be extended to the proton therapy passive delivery methods (single and double scattering) if the delivery of the irradiation is time-controlled with a known time-energy relationship. To derive the water equivalent path length (WEPL) from the energy resolved dose measurement, one may proceed in two different ways. A first method is by matching the measured energy resolved dose function to a pre-established calibration database of the behavior of the energy resolved dose in water, measured over the entire range of radiological depths with at least 1 mm spatial resolution. This calibration database can also be made specific to the patient if computed using the patient x-CT data. A second method to determine the WEPL is by using the empirical relationships between the WEPL and the integral dose or the depth at 80% of the proximal fall off of the energy resolved dose functions in water. In this note, we establish the evidence of the fundamental relationship between the energy resolved dose and the WEPL at the depth of the measurement. Then, we illustrate this relationship with experimental data and discuss its imaging dynamic range for 230 MeV protons.

  20. Concept of proton radiography using energy resolved dose measurement.

    Science.gov (United States)

    Bentefour, El H; Schnuerer, Roland; Lu, Hsiao-Ming

    2016-08-21

    Energy resolved dosimetry offers a potential path to single detector based proton imaging using scanned proton beams. This is because energy resolved dose functions encrypt the radiological depth at which the measurements are made. When a set of predetermined proton beams 'proton imaging field' are used to deliver a well determined dose distribution in a specific volume, then, at any given depth x of this volume, the behavior of the dose against the energies of the proton imaging field is unique and characterizes the depth x. This concept applies directly to proton therapy scanning delivery methods (pencil beam scanning and uniform scanning) and it can be extended to the proton therapy passive delivery methods (single and double scattering) if the delivery of the irradiation is time-controlled with a known time-energy relationship. To derive the water equivalent path length (WEPL) from the energy resolved dose measurement, one may proceed in two different ways. A first method is by matching the measured energy resolved dose function to a pre-established calibration database of the behavior of the energy resolved dose in water, measured over the entire range of radiological depths with at least 1 mm spatial resolution. This calibration database can also be made specific to the patient if computed using the patient x-CT data. A second method to determine the WEPL is by using the empirical relationships between the WEPL and the integral dose or the depth at 80% of the proximal fall off of the energy resolved dose functions in water. In this note, we establish the evidence of the fundamental relationship between the energy resolved dose and the WEPL at the depth of the measurement. Then, we illustrate this relationship with experimental data and discuss its imaging dynamic range for 230 MeV protons.

  1. Discovering approximate-associated sequence patterns for protein-DNA interactions

    KAUST Repository

    Chan, Tak Ming

    2010-12-30

    Motivation: The bindings between transcription factors (TFs) and transcription factor binding sites (TFBSs) are fundamental protein-DNA interactions in transcriptional regulation. Extensive efforts have been made to better understand the protein-DNA interactions. Recent mining on exact TF-TFBS-associated sequence patterns (rules) has shown great potentials and achieved very promising results. However, exact rules cannot handle variations in real data, resulting in limited informative rules. In this article, we generalize the exact rules to approximate ones for both TFs and TFBSs, which are essential for biological variations. Results: A progressive approach is proposed to address the approximation to alleviate the computational requirements. Firstly, similar TFBSs are grouped from the available TF-TFBS data (TRANSFAC database). Secondly, approximate and highly conserved binding cores are discovered from TF sequences corresponding to each TFBS group. A customized algorithm is developed for the specific objective. We discover the approximate TF-TFBS rules by associating the grouped TFBS consensuses and TF cores. The rules discovered are evaluated by matching (verifying with) the actual protein-DNA binding pairs from Protein Data Bank (PDB) 3D structures. The approximate results exhibit many more verified rules and up to 300% better verification ratios than the exact ones. The customized algorithm achieves over 73% better verification ratios than traditional methods. Approximate rules (64-79%) are shown statistically significant. Detailed variation analysis and conservation verification on NCBI records demonstrate that the approximate rules reveal both the flexible and specific protein-DNA interactions accurately. The approximate TF-TFBS rules discovered show great generalized capability of exploring more informative binding rules. © The Author 2010. Published by Oxford University Press. All rights reserved.

  2. Protection and Deception: Discovering Game Theory and Cyber Literacy through a Novel Board Game Experience

    OpenAIRE

    2015-01-01

    Cyber literacy merits serious research attention because it addresses a confluence of specialization and generalization; cybersecurity is often conceived of as approachable only by a technological intelligentsia, yet its interdependent nature demands education for a broad population. Therefore, educational tools should lead participants to discover technical knowledge in an accessible and attractive framework. In this paper, we present Protection and Deception (P&G), a novel two-player board ...

  3. A new hard X-ray transient discovered by INTEGRAL: IGR J17559-2612

    DEFF Research Database (Denmark)

    Esposito, V.; Ferrigno, C.; Bozzo, E.;

    2012-01-01

    INTEGRAL discovered a new hard X-ray transient, IGR J17559-2612, during the Galactic center observations performed from 2012-08-14 00:02:14 to 2012-08-14 14:45:54 UTC. The source is detected in the IBIS/ISGRI mosaic at a significance level of 8 σ (observation good time: 50 ks) both in the 20-40 k...

  4. Discovering Patterns in Symbolic Streams%符号流中的模式发现

    Institute of Scientific and Technical Information of China (English)

    李刚; 童铑

    2000-01-01

    The idea of discovering patterns in data seems to be essential for decision making in our social activities. This paper presents a simple algorithm which can be used to detect such patterns in elementary sequences of symbols. It adopts a data compression algorithm to seek for interesting patterns, which is important in understanding the way that the input symbol stream repeats itself. In this paper, the algorithm and related data structures are described in detail, and an illustrative example is given.

  5. Discovering Patterns in Symbolic Streams%符号流中的模式发现

    Institute of Scientific and Technical Information of China (English)

    李刚; 童頫

    2001-01-01

    The idea of discovering patterns in data seems to be essential for decision making in our social activities. This paper presents a simple algorithm which can be used to detect such patterns in elementary sequences of symbols. It adopts a data compression algorithm to seek for interesting patterns, which is important in understanding the way that the input symbol stream repeats itself. In this paper, the algorithm and related data structures are described in detail, and an illustrative example is given.

  6. A new hard X-ray source discovered by INTEGRAL: IGR J16442-554

    DEFF Research Database (Denmark)

    Bozzo, E.; Ferrigno, C.; Chenevez, Jérôme

    2009-01-01

    During a key program observation of the inner Galactic disc performed between 2009-08-30 14:04 and 2009-09-01 12:03 (UTC), a new source was discovered in the INTEGRAL/IBIS mosaic image. The best localization is RA: 251.088 DEC: -55.808, with a 90% error radius of 3.6 arcmin. The source, IGR J16442...

  7. A causal framework for discovering and removing direct and indirect discrimination

    OpenAIRE

    Zhang, Lu; Yongkai WU; Wu, Xintao

    2016-01-01

    Anti-discrimination is an increasingly important task in data science. In this paper, we investigate the problem of discovering both direct and indirect discrimination from the historical data, and removing the discriminatory effects before the data is used for predictive analysis (e.g., building classifiers). We make use of the causal network to capture the causal structure of the data. Then we model direct and indirect discrimination as the path-specific effects, which explicitly distinguis...

  8. Newly Discovered Herbig-Haro Objects near Haro 4-255

    Institute of Scientific and Technical Information of China (English)

    WANG Min; ZHAO Bing; DENG Li-Cai; CHEN Jian-Sheng

    2000-01-01

    We have performed CCD (charge coupled device) imaging toward the region near Haro 4-255 with a narrow band [SⅡ] filter and an intermediate band [BATC10] filter (BATC: the “Beijing-Arizona-Taiwan-Connecticut”multi-color sky survey project) and have discovered two Herbig-Haro (HH) objects, HH469 and HH470. They are identified to be driven by the Haro 4-255 (far-infrared) source and the T Tauri star Haro 4-255, respectively.

  9. The HBV E Genotype Discover in Dai Nationality in Xishuangbanna, Yunnan Province

    Institute of Scientific and Technical Information of China (English)

    Hai-ping ZHAO; Yuan-ying SHEN; Ru SHEN; Yuan-yi WANG; Mei-ya FU

    2009-01-01

    To investigate the distribution of Hepatitis B virus (HBV) genotypes among the population of Dai nationality in Xishuangbanna, Yurman Province HBV genotypes of the Serum samples were tested by PCR-RFLP. This is the first time to discover the B+E genotypes in China. This finding provides new information for understanding the distribution of HBV genotype in China and a provides a basis for establishing a Chinese gene bank.

  10. Extra large bauxite mines with 120 million tons discovered in Guangxi Congzuo

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>According to Guangxi General Institute of Geological Prospecting,after 3 years of hard work,prospecting team has discovered extra large bauxite mines with resources of 120 mil- lion tons in Youjiang area in Guangxi. It is said that the newly-found extra large baux- ite mines are situated in the city of Congzuo. The ore belt lays generally northeast with 50

  11. Discover Earth: an earth system science program for libraries and their communities

    Science.gov (United States)

    Dusenbery, P.

    2011-12-01

    The view from space has deepened our understanding of Earth as a global, dynamic system. Instruments on satellites and spacecraft, coupled with advances in ground-based research, have provided us with astonishing new perspectives of our planet. Now more than ever, enhancing the public's understanding of Earth's physical and biological systems is vital to helping citizens make informed policy decisions especially when they are faced with the consequences of global climate change. While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. The Space Science Institute's National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. STAR-Net includes two exhibitions: Discover Earth and Discover Tech. The Discover Earth exhibition will focus on local earth science topics-such as weather, water cycle, and ecosystem changes-as well as a global view of our changing planet. The main take-away message (or Big Idea) for this exhibition is that the global environment changes - and is changed by - the host community's local environment. The project team is testing whether this approach will be a good strategy for engaging the public, especially in rural America. This presentation will provide an overview of the Discover Earth project and how it is integrating climate change ideas into the exhibit

  12. A Model for Managing and Discovering Services Based on Dynamic Quality of Services

    Directory of Open Access Journals (Sweden)

    Hao-peng Chen

    2010-08-01

    Full Text Available  In this paper, we analyze the problems of existing Service Computing model and propose a model for managing and discovering services based on dynamic quality of services. This model consists of a Quality Measurement Center (QMC, which receives and analyzes the feedbacks of dynamic qualities of services to evaluate and rank the services according their dynamic qualities, and enables service consumer to search and discover services by the functional and/or QoS requirements; a QoS Spy, which feedbacks the real-time dynamic qualities of services to QMC and processes the fault detection and substitution of services; a Service Quality Calculator, which calculates the qualities of composite services based on their atomic services. With this model, we can evaluate and discover services on the Internet based on both functional and qualitative constraints. Meanwhile, this model is compatible with the basic principles of Service Computing, which are loosely coupled, protocol independent and location transparent. This model is the foundation of dynamic service discovery and substitution, and can improve the availability, scalability, and modifiability of service-based applications.  

  13. Mixture of Switching Linear Dynamics to Discover Behavior Patterns in Object Tracks.

    Science.gov (United States)

    Kooij, Julian F P; Englebienne, Gwenn; Gavrila, Dariu M

    2016-02-01

    We present a novel non-parametric Bayesian model to jointly discover the dynamics of low-level actions and high-level behaviors of tracked objects. In our approach, actions capture both linear, low-level object dynamics, and an additional spatial distribution on where the dynamic occurs. Furthermore, behavior classes capture high-level temporal motion dependencies in Markov chains of actions, thus each learned behavior is a switching linear dynamical system. The number of actions and behaviors is discovered from the data itself using Dirichlet Processes. We are especially interested in cases where tracks can exhibit large kinematic and spatial variations, e.g. person tracks in open environments, as found in the visual surveillance and intelligent vehicle domains. The model handles real-valued features directly, so no information is lost by quantizing measurements into 'visual words', and variations in standing, walking and running can be discovered without discrete thresholds. We describe inference using Markov Chain Monte Carlo sampling and validate our approach on several artificial and real-world pedestrian track datasets from the surveillance and intelligent vehicle domain. We show that our model can distinguish between relevant behavior patterns that an existing state-of-the-art hierarchical model for clustering and simpler model variants cannot. The software and the artificial and surveillance datasets are made publicly available for benchmarking purposes.

  14. Revealing of photon-number splitting attack on quantum key distribution system by photon-number resolving devices

    Science.gov (United States)

    Gaidash, A. A.; Egorov, V. I.; Gleim, A. V.

    2016-08-01

    Quantum cryptography allows distributing secure keys between two users so that any performed eavesdropping attempt would be immediately discovered. However, in practice an eavesdropper can obtain key information from multi-photon states when attenuated laser radiation is used as a source of quantum states. In order to prevent actions of an eavesdropper, it is generally suggested to implement special cryptographic protocols, like decoy states or SARG04. In this paper, we describe an alternative method based on monitoring photon number statistics after detection. We provide a useful rule of thumb to estimate approximate order of difference of expected distribution and distribution in case of attack. Formula for calculating a minimum value of total pulses or time-gaps to resolve attack is shown. Also formulas for actual fraction of raw key known to Eve were derived. This method can therefore be used with any system and even combining with mentioned special protocols.

  15. Understanding healthcare professionals' self-efficacy to resolve interprofessional conflict.

    Science.gov (United States)

    Sexton, Martha; Orchard, Carole

    2016-05-01

    Conflict within interprofessional healthcare teams, when not effectively resolved, has been linked to detrimental consequences; however, effective conflict resolution has been shown to enhance team performance, increase patient safety, and improve patient outcomes. Alarmingly, knowledge of healthcare professionals' ability to resolve conflict has been limited, largely due to the challenges that arise when researchers attempt to observe a conflict occurring in real time. Research literature has identified three central components that seem to influence healthcare professional's perceived ability to resolve conflict: communication competence, problem-solving ability, and conflict resolution education and training. The purpose of this study was to investigate the impact of communication competence, problem-solving ability, and conflict resolution education and training on healthcare professionals' perceived ability to resolve conflicts. This study employed a cross-sectional survey design. Multiple regression analyses demonstrated that two of the three central components-conflict resolution education and training and communication competence-were found to be statistically significant predictors of healthcare professionals' perceived ability to resolve conflict. Implications include a call to action for clinicians and academicians to recognize the importance of communication competence and conflict resolution education and training as a vital area in interprofessional pre- and post-licensure education and collaborative practice.

  16. Ozone production and its sensitivity to NOx and VOCs: results from the DISCOVER-AQ field experiment, Houston 2013

    Science.gov (United States)

    Mazzuca, Gina M.; Ren, Xinrong; Loughner, Christopher P.; Estes, Mark; Crawford, James H.; Pickering, Kenneth E.; Weinheimer, Andrew J.; Dickerson, Russell R.

    2016-11-01

    An observation-constrained box model based on the Carbon Bond mechanism, version 5 (CB05), was used to study photochemical processes along the NASA P-3B flight track and spirals over eight surface sites during the September 2013 Houston, Texas deployment of the NASA Deriving Information on Surface Conditions from COlumn and VERtically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) campaign. Data from this campaign provided an opportunity to examine and improve our understanding of atmospheric photochemical oxidation processes related to the formation of secondary air pollutants such as ozone (O3). O3 production and its sensitivity to NOx and volatile organic compounds (VOCs) were calculated at different locations and times of day. Ozone production efficiency (OPE), defined as the ratio of the ozone production rate to the NOx oxidation rate, was calculated using the observations and the simulation results of the box and Community Multiscale Air Quality (CMAQ) models. Correlations of these results with other parameters, such as radical sources and NOx mixing ratio, were also evaluated. It was generally found that O3 production tends to be more VOC-sensitive in the morning along with high ozone production rates, suggesting that control of VOCs may be an effective way to control O3 in Houston. In the afternoon, O3 production was found to be mainly NOx-sensitive with some exceptions. O3 production near major emissions sources such as Deer Park was mostly VOC-sensitive for the entire day, other urban areas near Moody Tower and Channelview were VOC-sensitive or in the transition regime, and areas farther from downtown Houston such as Smith Point and Conroe were mostly NOx-sensitive for the entire day. It was also found that the control of NOx emissions has reduced O3 concentrations over Houston but has led to larger OPE values. The results from this work strengthen our understanding of O3 production; they indicate that controlling NOx emissions will provide

  17. Time-resolved vortex wake of a common swift flying over a range of flight speeds.

    Science.gov (United States)

    Henningsson, P; Muijres, F T; Hedenström, A

    2011-06-06

    The wake of a freely flying common swift (Apus apus L.) is examined in a wind tunnel at three different flight speeds, 5.7, 7.7 and 9.9 m s(-1). The wake of the bird is visualized using high-speed stereo digital particle image velocimetry (DPIV). Wake images are recorded in the transverse plane, perpendicular to the airflow. The wake of a swift has been studied previously using DPIV and recording wake images in the longitudinal plane, parallel to the airflow. The high-speed DPIV system allows for time-resolved wake sampling and the result shows features that were not discovered in the previous study, but there was approximately a 40 per cent vertical force deficit. As the earlier study also revealed, a pair of wingtip vortices are trailing behind the wingtips, but in addition, a pair of tail vortices and a pair of 'wing root vortices' are found that appear to originate from the wing/body junction. The existence of wing root vortices suggests that the two wings are not acting as a single wing, but are to some extent aerodynamically detached from each other. It is proposed that this is due to the body disrupting the lift distribution over the wing by generating less lift than the wings.

  18. Spatially resolved atomic and molecular emission from the very low-mass star IRS54

    CERN Document Server

    Lopez, R Garcia; Weigelt, G; Nisini, B; Antoniucci, S

    2013-01-01

    Molecular outflows from very low-mass stars (VLMSs) and brown dwarfs (BDs) have been studied very little, and only a few objects have been directly imaged. Using VLT SINFONI K-band observations, we spatially resolved, for the first time, the H2 emission around IRS54, a ~0.1-0.2 Msun Class I source. The molecular emission shows a complex structure delineating a large outflow cavity and an asymmetric molecular jet. In addition, new [FeII] VLT ISAAC observations at 1.644um allowed us to discover the atomic jet counterpart which extends down to the central source. The outflow structure is similar to those found in low-mass Class I young stellar objects (YSOs) and Classical TTauri stars (CTTSs). However, its Lacc/Lbol ratio is very high (~80%), and the derived mass accretion rate is about one order of magnitude higher than in objects with similar mass, pointing to the young nature of the investigated source.

  19. Resolving Gas Flows in the Ultraluminous Starburst IRAS23365+3604 with Keck LGSAO/OSIRIS

    CERN Document Server

    Martin, Crystal L

    2015-01-01

    Keck OSIRIS/LGSAO observations of the ultraluminous galaxy IRAS 23365+3604 resolve a non-axisymmetric, circumnuclear structure of semi-major axis 0.42" (520 pc) in Paschen-alpha emission. The line-of-sight velocity of the ionized gas increases from the northeast towards the southwest; this gradient is perpendicular to the photometric major axis of the infrared emission. Two pairs of bends in the zero velocity line are detected. The inner bend provides evidence for gas inflow onto the circumnuclear structure. We interpret the gas kinematics on kiloparsec scales in relation to the molecular gas disk and multiphase outflow discovered previously. In particular, the fast component of the outflow (detected previously with lower spatial resolution) is not detected, adding support to the conjecture that the fast wind originates well-beyond the nucleus. These data directly show the dynamics of gas inflow and outflow in the central kiloparsec of a late-stage, gas-rich merger and demonstrate the potential of integral fi...

  20. RESOLVING GAS FLOWS IN THE ULTRALUMINOUS STARBURST IRAS 23365+3604 WITH KECK LGSAO/OSIRIS

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Crystal L. [Physics Department, University of California, Santa Barbara, CA 93106-9530 (United States); Soto, Kurt T. [Institute for Astronomy, ETH Zurich, Zurich 8093 (Switzerland)

    2016-03-01

    Keck OSIRIS/LGSAO observations of the ultraluminous galaxy IRAS 23365+3604 resolve a circumnuclear bar (or irregular disk) of semimajor axis 0.″42 (520 pc) in Paα emission. The line-of-sight velocity of the ionized gas increases from the northeast toward the southwest; this gradient is perpendicular to the photometric major axis of the infrared emission. Two pairs of bends in the zero-velocity line are detected. The inner bend provides evidence for gas inflow onto the circumnuclear disk/bar structure. We interpret the gas kinematics on kiloparsec scales in relation to the molecular gas disk and multiphase outflow discovered previously. In particular, the fast component of the ouflow (detected previously in line wings) is not detected, adding support to the conjecture that the fast wind originates well beyond the nucleus. These data directly show the dynamics of gas inflow and outflow in the central kiloparsec of a late-stage, gas-rich merger and demonstrate the potential of integral field spectroscopy to improve our understanding of the role of gas flows during the growth phase of bulges and supermassive black holes.

  1. Dirac cones, Floquet side bands, and theory of time-resolved angle-resolved photoemission

    Science.gov (United States)

    Farrell, Aaron; Arsenault, A.; Pereg-Barnea, T.

    2016-10-01

    Pump-probe techniques with high temporal resolution allow one to drive a system of interest out of equilibrium and at the same time probe its properties. Recent advances in these techniques open the door to studying new, nonequilibrium phenomena such as Floquet topological insulators and superconductors. These advances also necessitate the development of theoretical tools for understanding the experimental findings and predicting new ones. In the present paper, we provide a theoretical foundation to understand the nonequilibrium behavior of a Dirac system. We present detailed numerical calculations and simple analytic results for the time evolution of a Dirac system irradiated by light. These results are framed by appealing to the recently revitalized notion of side bands [A. Farrell and T. Pereg-Barnea, Phys. Rev. Lett. 115, 106403 (2015), 10.1103/PhysRevLett.115.106403; Phys. Rev. B 93, 045121 (2016), 10.1103/PhysRevB.93.045121], extended to the case of nonperiodic drive where the fast oscillations are modified by an envelope function. We apply this formalism to the case of photocurrent generated by a second probe pulse. We find that, under the application of circularly polarized light, a Dirac point only ever splits into two copies of side bands. Meanwhile, the application of linearly polarized light leaves the Dirac point intact while producing side bands. In both cases the population of the side bands are time dependent through their nonlinear dependence on the envelope of the pump pulse. Our immediate interest in this work is in connection to time- and angle-resolved photoemission experiments, where we find excellent qualitative agreement between our results and those in the literature [Wang et al., Science 342, 453 (2013), 10.1126/science.1239834]. However, our results are general and may prove useful beyond this particular application and should be relevant to other pump-probe experiments.

  2. 25 CFR 224.87 - What are the obligations of a tribe if it discovers a violation or breach?

    Science.gov (United States)

    2010-04-01

    ... violation or breach? 224.87 Section 224.87 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... DETERMINATION ACT Implementation of Tribal Energy Resource Agreements Violation Or Breach § 224.87 What are the obligations of a tribe if it discovers a violation or breach? As soon as practicable after discovering...

  3. Nitrogen dioxide observations from the Geostationary Trace gas and Aerosol Sensor Optimization (GeoTASO airborne instrument: retrieval algorithm and measurements during DISCOVER-AQ Texas 2013

    Directory of Open Access Journals (Sweden)

    C. R. Nowlan

    2015-12-01

    Full Text Available The Geostationary Trace gas and Aerosol Sensor Optimization (GeoTASO airborne instrument is a testbed for upcoming air quality satellite instruments that will measure backscattered ultraviolet, visible and near-infrared light from geostationary orbit. GeoTASO flew on the NASA Falcon aircraft in its first intensive field measurement campaign during the Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER-AQ Earth Venture Mission over Houston, Texas in September 2013. Measurements of backscattered solar radiation between 420–465 nm collected on four days during the campaign are used to determine slant column amounts of NO2 at 250 m × 250 m spatial resolution with a fitting precision of 2.2 × 1015 molecules cm−2. These slant columns are converted to tropospheric NO2 vertical columns using a radiative transfer model and trace gas profiles from the Community Multiscale Air Quality (CMAQ model. Total column NO2 from GeoTASO is well correlated with ground-based Pandora observations (r = 0.90 on the most polluted and cloud-free day of measurements, with GeoTASO NO2 slightly higher for the most polluted observations. Surface NO2 mixing ratios inferred from GeoTASO using the CMAQ model show good correlation with NO2 measured in situ at the surface during the campaign (r = 0.91 for the most polluted day. NO2 slant columns from GeoTASO also agree well with preliminary retrievals from the GEO-CAPE Airborne Simulator (GCAS which flew on the NASA King Air B200 (r = 0.84, slope = 0.94. Enhanced NO2 is resolvable over areas of traffic NOx emissions and near individual petrochemical facilities.

  4. Super-resolved imaging with ultimate time resolution

    CERN Document Server

    Ashida, Yuto

    2015-01-01

    Precisely and accurately locating point objects is a long-standing common thread in science. Super-resolved imaging of single molecules has revolutionized our view of quasi-static nanostructures $\\it{in-vivo}$. A wide-field approach based on localizing individual fluorophores has emerged as a versatile method to surpass the standard resolution limit. In those techniques, the super-resolution is realized by sparse photoactivation and localization together with the statistical analysis based on point spread functions. Nevertheless, the slow temporal resolution of super-resolved imaging severely restricts the utility to the study of live-cell phenomena. Clearly, a major breakthrough to observe fast, nanoscale dynamics needs to be made. Here we present a super-resolved imaging method that achieves the theoretical-limit time resolution. By invoking information theory, we can achieve the robust localization of overlapped light emitters at an order of magnitude faster speed than the conventional super-resolution mic...

  5. The Algol triple system spatially resolved at optical wavelengths

    CERN Document Server

    Zavala, R T; Boboltz, D A; Ojha, R; Shaffer, D B; Tycner, C; Richards, M T; Hutter, D J; 10.1088/2041-8205/715/1/L44

    2010-01-01

    Interacting binaries typically have separations in the milli-arcsecond regime and hence it has been challenging to resolve them at any wavelength. However, recent advances in optical interferometry have improved our ability to discern the components in these systems and have now enabled the direct determination of physical parameters. We used the Navy Prototype Optical Interferometer to produce for the first time images resolving all three components in the well-known Algol triple system. Specifically, we have separated the tertiary component from the binary and simultaneously resolved the eclipsing binary pair, which represents the nearest and brightest eclipsing binary in the sky. We present revised orbital elements for the triple system, and we have rectified the 180-degree ambiguity in the position angle of Algol C. Our directly determined magnitude differences and masses for this triple star system are consistent with earlier light curve modeling results.

  6. RESOLVE's Field Demonstration on Mauna Kea, Hawaii 2010

    Science.gov (United States)

    Captain, Janine; Quinn, Jacqueline; Moss, Thomas; Weis, Kyle

    2010-01-01

    In cooperation with the Canadian Space Agency, and the Northern Centre for Advanced Technology, Inc., NASA has undertaken the In-Situ Resource Utilization (ISRU) project called RESOLVE (Regolith and Environment Science & Oxygen and Lunar Volatile Extraction). This project is an Earth-based lunar precursor demonstration of a system that could be sent to explore permanently shadowed polar lunar craters, where it would drill into regolith, quantify the volatiles that are present, and extract oxygen by hydrogen reduction of iron oxides. The resulting water could be electrolyzed into oxygen to support exploration and hydrogen, which would be recycled through the process. The RESOLVE chemical processing system was mounted on a Canadian Space Agency mobility chasis and successfully demonstrated on Hawaii's Mauna Kea volcano in February 2010. The RESOLVE unit is the initial prototype of a robotic prospecting mission to the Moon. RESOLVE is designed to go to the poles of the Moon to "ground truth" the form and concentration of the hydrogen/water/hydroxyl that has been seen from orbit (M3, Lunar Prospector and LRO) and to test technologies to extract oxygen from the lunar regolith. RESOLVE has the ability to capture a one-meter core sample of lunar regolith and heat it to determine the volatiles that may be released and then demonstrate the production of oxygen from minerals found in the regolith. The RESOLVE project, which is led by KSC, is a multi-center and multi-organizational effort that includes representatives from KSC, JSC, GRC, the Canadian Space Agency, and the Northern Center for Advanced Technology (NORCAT). This paper details the results obtained from four days of lunar analog testing that included gas chromatograph analysis for volatile components, remote control of chemistry and drilling operations via satalite communications, and real-time water quantification using a novel capacitance measurement technique.

  7. Chandra Resolves Cosmic X-ray Glow and Finds Mysterious New Sources

    Science.gov (United States)

    2000-01-01

    While taking a giant leap towards solving one of the greatest mysteries of X-ray astronomy, NASA's Chandra X-ray Observatory also may have revealed the most distant objects ever seen in the universe and discovered two puzzling new types of cosmic objects. Not bad for being on the job only five months. Chandra has resolved most of the X-ray background, a pervasive glow of X-rays throughout the universe, first discovered in the early days of space exploration. Before now, scientists have not been able to discern the background's origin, because no X-ray telescope until Chandra has had both the angular resolution and sensitivity to resolve it. "This is a major discovery," said Dr. Alan Bunner, Director of NASA's Structure andEvolution of the universe science theme. "Since it was first observed thirty-seven years ago, understanding the source of the X-ray background has been aHoly Grail of X-ray astronomy. Now, it is within reach." The results of the observation will be discussed today at the 195th national meeting of the American Astronomical Society in Atlanta, Georgia. An article describing this work has been submitted to the journal Nature by Dr. Richard Mushotzky, of NASA Goddard Space Flight Center, Greenbelt, Md., Drs. Lennox Cowie and Amy Barger at the University of Hawaii, Honolulu, and Dr. Keith Arnaud of the University of Maryland, College Park. "We are all very excited by this finding," said Mushotzky. "The resolution of most of the hard X-ray background during the first few months of the Chandra mission is a tribute to the power of this observatory and bodes extremely well for its scientific future," Scientists have known about the X-ray glow, called the X-ray background, since the dawn of X-ray astronomy in the early 1960s. They have been unable to discern its origin, however, for no X-ray telescope until Chandra has had both the angular resolution and sensitivity to resolve it. The German-led ROSAT mission, now completed, resolved much of the lower

  8. RESOLVE OVEN Field Demonstration Unit for Lunar Resource Extraction

    Science.gov (United States)

    Paz, Aaron; Oryshchyn, Lara; Jensen, Scott; Sanders, Gerald B.; Lee, Kris; Reddington, Mike

    2013-01-01

    The Oxygen and Volatile Extraction Node (OVEN) is a subsystem within the Regolith & Environment Science and Oxygen & Lunar Volatile Extraction (RESOLVE) project. The purpose of the OVEN subsystem is to release volatiles from lunar regolith and extract oxygen by means of a hydrogen reduction reaction. The complete process includes receiving, weighing, sealing, heating, and disposing of core sample segments while transferring all gaseous contents to the Lunar Advanced Volatile Analysis (LAVA) subsystem. This document will discuss the design and performance of the OVEN Field Demonstration Unit (FDU), which participated in the 2012 RESOLVE field demonstration.

  9. The role of mediation in resolving workplace relationship conflict.

    Science.gov (United States)

    McKenzie, Donna Margaret

    2015-01-01

    Stress triggered by workplace-based interpersonal conflict can result in damaged relationships, loss of productivity, diminished job satisfaction and increasingly, workers' compensation claims for psychological injury. This paper examined the literature on the role and effectiveness of mediation, as the most common method of Alternative Dispute Resolution, in resolving workplace relationship conflict. Available evidence suggests that mediation is most effective when supported by organisational commitment to ADR strategies, policies and processes, and conducted by independent, experienced and qualified mediators. The United States Postal Service program REDRESS™ is described as an illustration of the successful use of mediation to resolve conflict in the workplace.

  10. Time-resolved photon emission from layered turbid media

    Energy Technology Data Exchange (ETDEWEB)

    Hielscher, A.H. [Department of Electrical and Computer Engineering, Rice University, 6100 South Main, Houston, Texas 77251-1892 (United States); Liu, H.; Chance, B. [Department of Biochemistry and Biophysics, University of Pennsylvania, D501 Richards Building, Philadelphia, Pennsylvania 19104-6089 (United States); Tittel, F.K. [Department of Electrical and Computer Engineering, Rice University, 6100 South Main, Houston, Texas 77251-1892 (United States); Jacques, S.L. [Laser Biology Research Laboratory, Box 17, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States)

    1996-02-01

    We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze {ital in} {ital vivo} measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain. {copyright} {ital 1996 Optical Society of America.}

  11. Direct vs. resolved photon an exercise in factorization

    CERN Document Server

    Chyla, J

    1994-01-01

    Direct and resolved photon interactions are shown to be intimately related through the factorization mechanism. It is argued that in theoretically consistent analysis of jet production in $\\gamma$p and ep collisions the LO resolved $\\gamma$ contribution must be considered together with the NLO direct $\\gamma$ component. Recent data from HERA therefore do not provide a direct evidence for the former component, but should rather be interpreted as a manifestation of the $O(\\alpha\\alpha_s^2)$ term in $\\gamma$p and, via the Weizs\\"acker-Williams approximation, in ep interactions.

  12. Adaptive Subchip Multipath Resolving for Wireless Location Systems

    Directory of Open Access Journals (Sweden)

    Yousef Nabil R

    2006-01-01

    Full Text Available Reliable positioning of cellular users in a mobile environment requires accurate resolving of overlapping multipath components. However, this task is difficult due to fast channel fading conditions and data ill-conditioning, which limit the performance of least-squares-based techniques. This paper develops two overlapping multipath resolving methods (adaptive and nonadaptive, and shows how the adaptive solution can be made robust to the above limitations by extracting and exploiting a priori information about the fading channel. Also the proposed techniques are extended when there are antenna arrays at the base station. Simulation results illustrate the performance of the proposed techniques.

  13. Local resolved electrochemical impedance spectroscopy of PEFC single cells

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, M.; Gulzow, E. [German Aerospace Center, Inst. of Technical Thermodynamics, Stuttgart (Germany)

    2009-07-01

    Experimental data on a spatial resolved level is needed to understand the integral behaviour of fuel cells as well as to validate models describing fuel cell behaviour. This paper described a new tool developed to increase the accuracy of current density measurements. Based on a printed circuit board, the tool integrated local electrochemical impedance spectroscopy techniques in order to determine local membrane resistance, electrochemical reactions, and transport processes. Solutions for locally resolved impedance spectroscopy measurements were presented. It was concluded that the tool will help to provide a more detailed understanding of fuel cell behaviour.

  14. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

    Science.gov (United States)

    Jahanshad, Neda; Rajagopalan, Priya; Hua, Xue; Hibar, Derrek P.; Nir, Talia M.; Toga, Arthur W.; Jack, Clifford R.; Saykin, Andrew J.; Green, Robert C.; Weiner, Michael W.; Medland, Sarah E.; Montgomery, Grant W.; Hansell, Narelle K.; McMahon, Katie L.; de Zubicaray, Greig I.; Martin, Nicholas G.; Wright, Margaret J.; Thompson, Paul M.; Weiner, Michael; Aisen, Paul; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Liu, Enchi; Green, Robert C.; Montine, Tom; Petersen, Ronald; Aisen, Paul; Gamst, Anthony; Thomas, Ronald G.; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Beckett, Laurel; Harvey, Danielle; Gamst, Anthony; Donohue, Michael; Kornak, John; Jack, Clifford R.; Dale, Anders; Bernstein, Matthew; Felmlee, Joel; Fox, Nick; Thompson, Paul; Schuff, Norbert; Alexander, Gene; DeCarli, Charles; Jagust, William; Bandy, Dan; Koeppe, Robert A.; Foster, Norm; Reiman, Eric M.; Chen, Kewei; Mathis, Chet; Morris, John; Cairns, Nigel J.; Taylor-Reinwald, Lisa; Trojanowki, J.Q.; Shaw, Les; Lee, Virginia M.Y.; Korecka, Magdalena; Toga, Arthur W.; Crawford, Karen; Neu, Scott; Saykin, Andrew J.; Foroud, Tatiana M.; Potkin, Steven; Shen, Li; Khachaturian, Zaven; Frank, Richard; Snyder, Peter J.; Molchan, Susan; Kaye, Jeffrey; Quinn, Joseph; Lind, Betty; Dolen, Sara; Schneider, Lon S.; Pawluczyk, Sonia; Spann, Bryan M.; Brewer, James; Vanderswag, Helen; Heidebrink, Judith L.; Lord, Joanne L.; Petersen, Ronald; Johnson, Kris; Doody, Rachelle S.; Villanueva-Meyer, Javier; Chowdhury, Munir; Stern, Yaakov; Honig, Lawrence S.; Bell, Karen L.; Morris, John C.; Ances, Beau; Carroll, Maria; Leon, Sue; Mintun, Mark A.; Schneider, Stacy; Marson, Daniel; Griffith, Randall; Clark, David; Grossman, Hillel; Mitsis, Effie; Romirowsky, Aliza; deToledo-Morrell, Leyla; Shah, Raj C.; Duara, Ranjan; Varon, Daniel; Roberts, Peggy; Albert, Marilyn; Onyike, Chiadi; Kielb, Stephanie; Rusinek, Henry; de Leon, Mony J.; Glodzik, Lidia; De Santi, Susan; Doraiswamy, P. Murali; Petrella, Jeffrey R.; Coleman, R. Edward; Arnold, Steven E.; Karlawish, Jason H.; Wolk, David; Smith, Charles D.; Jicha, Greg; Hardy, Peter; Lopez, Oscar L.; Oakley, MaryAnn; Simpson, Donna M.; Porsteinsson, Anton P.; Goldstein, Bonnie S.; Martin, Kim; Makino, Kelly M.; Ismail, M. Saleem; Brand, Connie; Mulnard, Ruth A.; Thai, Gaby; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Diaz-Arrastia, Ramon; King, Richard; Weiner, Myron; Martin-Cook, Kristen; DeVous, Michael; Levey, Allan I.; Lah, James J.; Cellar, Janet S.; Burns, Jeffrey M.; Anderson, Heather S.; Swerdlow, Russell H.; Apostolova, Liana; Lu, Po H.; Bartzokis, George; Silverman, Daniel H.S.; Graff-Radford, Neill R.; Parfitt, Francine; Johnson, Heather; Farlow, Martin R.; Hake, Ann Marie; Matthews, Brandy R.; Herring, Scott; van Dyck, Christopher H.; Carson, Richard E.; MacAvoy, Martha G.; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Hsiung, Ging-Yuek Robin; Feldman, Howard; Mudge, Benita; Assaly, Michele; Kertesz, Andrew; Rogers, John; Trost, Dick; Bernick, Charles; Munic, Donna; Kerwin, Diana; Mesulam, Marek-Marsel; Lipowski, Kristina; Wu, Chuang-Kuo; Johnson, Nancy; Sadowsky, Carl; Martinez, Walter; Villena, Teresa; Turner, Raymond Scott; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa A.; Johnson, Keith A.; Marshall, Gad; Frey, Meghan; Yesavage, Jerome; Taylor, Joy L.; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan; Belden, Christine; Jacobson, Sandra; Kowall, Neil; Killiany, Ronald; Budson, Andrew E.; Norbash, Alexander; Johnson, Patricia Lynn; Obisesan, Thomas O.; Wolday, Saba; Bwayo, Salome K.; Lerner, Alan; Hudson, Leon; Ogrocki, Paula; Fletcher, Evan; Carmichael, Owen; Olichney, John; DeCarli, Charles; Kittur, Smita; Borrie, Michael; Lee, T.-Y.; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia M.; Potkin, Steven G.; Preda, Adrian; Nguyen, Dana; Tariot, Pierre; Fleisher, Adam; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas W.; Kataki, Maria; Zimmerman, Earl A.; Celmins, Dzintra; Brown, Alice D.; Pearlson, Godfrey D.; Blank, Karen; Anderson, Karen; Saykin, Andrew J.; Santulli, Robert B.; Schwartz, Eben S.; Sink, Kaycee M.; Williamson, Jeff D.; Garg, Pradeep; Watkins, Franklin; Ott, Brian R.; Querfurth, Henry; Tremont, Geoffrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard J.; Miller, Bruce L.; Mintzer, Jacobo; Longmire, Crystal Flynn; Spicer, Kenneth; Finger, Elizabeth; Rachinsky, Irina; Rogers, John; Kertesz, Andrew; Drost, Dick

    2013-01-01

    Aberrant connectivity is implicated in many neurological and psychiatric disorders, including Alzheimer’s disease and schizophrenia. However, other than a few disease-associated candidate genes, we know little about the degree to which genetics play a role in the brain networks; we know even less about specific genes that influence brain connections. Twin and family-based studies can generate estimates of overall genetic influences on a trait, but genome-wide association scans (GWASs) can screen the genome for specific variants influencing the brain or risk for disease. To identify the heritability of various brain connections, we scanned healthy young adult twins with high-field, high-angular resolution diffusion MRI. We adapted GWASs to screen the brain’s connectivity pattern, allowing us to discover genetic variants that affect the human brain’s wiring. The association of connectivity with the SPON1 variant at rs2618516 on chromosome 11 (11p15.2) reached connectome-wide, genome-wide significance after stringent statistical corrections were enforced, and it was replicated in an independent subsample. rs2618516 was shown to affect brain structure in an elderly population with varying degrees of dementia. Older people who carried the connectivity variant had significantly milder clinical dementia scores and lower risk of Alzheimer’s disease. As a posthoc analysis, we conducted GWASs on several organizational and topological network measures derived from the matrices to discover variants in and around genes associated with autism (MACROD2), development (NEDD4), and mental retardation (UBE2A) significantly associated with connectivity. Connectome-wide, genome-wide screening offers substantial promise to discover genes affecting brain connectivity and risk for brain diseases. PMID:23471985

  15. New variable stars discovered in the fields of three Galactic open clusters using the VVV survey

    Science.gov (United States)

    Palma, T.; Minniti, D.; Dékány, I.; Clariá, J. J.; Alonso-García, J.; Gramajo, L. V.; Ramírez Alegría, S.; Bonatto, C.

    2016-11-01

    This project is a massive near-infrared (NIR) search for variable stars in highly reddened and obscured open cluster (OC) fields projected on regions of the Galactic bulge and disk. The search is performed using photometric NIR data in the J-, H- and Ks- bands obtained from the Vista Variables in the Vía Láctea (VVV) Survey. We performed in each cluster field a variability search using Stetson's variability statistics to select the variable candidates. Later, those candidates were subjected to a frequency analysis using the Generalized Lomb-Scargle and the Phase Dispersion Minimization algorithms. The number of independent observations range between 63 and 73. The newly discovered variables in this study, 157 in total in three different known OCs, are classified based on their light curve shapes, periods, amplitudes and their location in the corresponding color-magnitude (J -Ks ,Ks) and color-color (H -Ks , J - H) diagrams. We found 5 possible Cepheid stars which, based on the period-luminosity relation, are very likely type II Cepheids located behind the bulge. Among the newly discovered variables, there are eclipsing binaries, δ Scuti, as well as background RR Lyrae stars. Using the new version of the Wilson & Devinney code as well as the "Physics Of Eclipsing Binaries" (PHOEBE) code, we analyzed some of the best eclipsing binaries we discovered. Our results show that these studied systems turn out to be ranging from detached to double-contact binaries, with low eccentricities and high inclinations of approximately 80°. Their surface temperatures range between 3500 K and 8000 K.

  16. Swift follow-up of the newly discovered burster millisecond pulsar IGR J17511-3057

    DEFF Research Database (Denmark)

    Bozzo, E.; Ferrigno, C.; Kuulkers, E.;

    2009-01-01

    2.5 ks were accumulated in window timing (WT) mode. A thermonuclear type-I X-ray burst was discovered in the WT light curve of the source at 2009-09-14 00:51:37 UTC with an exponential decay time of ~12.5 s. This burst is most likely a He burst. The WT 0.5-10 keV X-ray spectrum is well described.......2+/-0.2. The absorbed 0.5-10 keV X-ray flux is 6.0e-10 ergs/cm^2/s....

  17. Palomar Transient Factory Discovers Another Possible super- Chandrasekhar Type Ia Supernova

    Science.gov (United States)

    Nugent, P. E.; Howell, D. A.; Sullivan, M.; Suzuki, N.; Cucchiara, A.; Botyanszki, J.; Hsiao, E. Y.

    2010-10-01

    The Type Ia supernova science working group of the Palomar Transient Factory (ATEL#1964) reports the discovery of a possible super-Chandrasekhar mass supernova, PTF10xgx. The supernova is at RA = 00:12:23.15, Dec = +02:30:44.1 (J2000) in the galaxy identified as APMUKS(BJ) B000949.39+021401.7 (Maddox et al. 1990, MNRAS, 243, 692). The supernova was discovered and classified by Oarical, an autonomous software framework of the PTF collaboration, based on observations made with the Palomar 48-inch Oschin Schmidt telescope.

  18. The newly discovered eclipsing cataclysmic star 2MASS J16211735 + 4412541 and its peculiarity

    Science.gov (United States)

    Kjurkchieva, Diana P.; Popov, Velimir A.; Vasileva, Doroteya L.; Petrov, Nikola I.

    2017-04-01

    We present our observations of the newly discovered, eclipsing cataclysmic star 2MASS J16211735 + 4412541 carried out two weeks after its outburst at the beginning of June 2016. Its main peculiarity is the big increasing of eclipse depth during outburst. We qualitatively modelled the folded light curves at quiescence and outburst in order to explain the reason for increase of the primary luminosity about two hundred times. The light curve fits revealed that such an effect can be reproduced by a flat disc whose radius and temperature are several times bigger than those of the primary at quiescence.

  19. Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

    DEFF Research Database (Denmark)

    Roque, Francisco S.; Jensen, Peter B.; Schmock, Henriette;

    2011-01-01

    Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe a general approach for gathering phenotypic descriptions of patients from medical records in a systematic and non-cohort dependent manner. By extracting...... phenotype information from the free-text in such records we demonstrate that we can extend the information contained in the structured record data, and use it for producing fine-grained patient stratification and disease co-occurrence statistics. The approach uses a dictionary based on the International...

  20. Comments on the newly discovered advection dominated flows around black holes and neutron stars

    CERN Document Server

    Chakrabarti, S K

    1995-01-01

    We provide complete and global solutions of transonic flows around black holes, in presence of advection, rotation, heating and cooling. We show that for any degree of advection, there may exist two critical viscosity parameters \\alpha_{c1, c2} such that for \\alpha \\alpha_{c2}, the flow may again pass through the inner sonic point, depending on flow parameters. No new topologies emerge other than what we found earlier while studying viscous isothermal transonic flows. These findings indicate that the newly discovered advection dominated flows do not constitute any new solutions.

  1. Relatório de Estágio Curricular – DIP – Discover Inland Portugal

    OpenAIRE

    Estevães, Pedro; Simões, Philip

    2011-01-01

    A DIP – Discover Inland Portugal consiste na criação de uma agência de viagens e turismo de outgoing, que promove e comercializa produtos turísticos diversificados, inovadores e singulares para a região da Beira Interior Centro, através de uma plataforma online. A necessidade e oportunidade existente na região por canais de distribuição agregadores, torna o projecto DIP numa forte aposta e investimento para o turismo praticado na região Interior Centro. A utilização da tecnologia do comérc...

  2. Spitzer Observations of Exoplanets Discovered with The Kepler K2 Mission

    CERN Document Server

    Beichman, Charles; Werner, Michael; Gorjian, Varoujan; Krick, Jessica; Deck, Katherine; Knutson, Heather; Wong, Ian; Petigura, Erik A; Christiansen, Jessie; Ciardi, David; Greene, Thomas P; Schlieder, Joshua E; Line, Mike; Crossfield, Ian; Howard, Andrew; Sinukoff, Evan

    2016-01-01

    We have used the {\\it Spitzer Space Telescope} to observe two transiting planetary systems orbiting low mass stars discovered in the \\Kepler \\Ktwo mission. The system K2-3 (EPIC 201367065) hosts three planets while EPIC 202083828 (K2-26) hosts a single planet. Observations of all four objects in these two systems confirm and refine the orbital and physical parameters of the planets. The refined orbital information and more precise planet radii possible with \\Spitzer will be critical for future observations of these and other \\Ktwo targets. For K2-3b we find marginally significant evidence for a Transit Timing Variation between the \\Ktwo and \\Spitzer\\ epochs.

  3. Tidal Streams in Newly Discovered compact elliptical (cE) galaxies

    CERN Document Server

    Huxor, Avon; Price, James; Harniman, Rob

    2010-01-01

    We present two newly-discovered, compact elliptical (cE) galaxies, which exhibit clear evidence of tidal steams, found in a search of SDSS DR7. The structural parameters of the cEs are derived using GALFIT and give effective radii < 400 pc. They also possess young to intermediate-age stellar populations. These two cEs provide direct evidence, a "smoking gun", for the process of tidal stripping that is believed to be the origin of M32-type galaxies. Both are found in small group environments with many late-type galaxies, suggesting that we may be seeing the formation of such galaxies in dynamically young galaxy groups.

  4. Swarm intelligence in bioinformatics: methods and implementations for discovering patterns of multiple sequences.

    Science.gov (United States)

    Cui, Zhihua; Zhang, Yi

    2014-02-01

    As a promising and innovative research field, bioinformatics has attracted increasing attention recently. Beneath the enormous number of open problems in this field, one fundamental issue is about the accurate and efficient computational methodology that can deal with tremendous amounts of data. In this paper, we survey some applications of swarm intelligence to discover patterns of multiple sequences. To provide a deep insight, ant colony optimization, particle swarm optimization, artificial bee colony and artificial fish swarm algorithm are selected, and their applications to multiple sequence alignment and motif detecting problem are discussed.

  5. Time-resolved and position-resolved X-ray spectrometry with a pixelated detector

    Energy Technology Data Exchange (ETDEWEB)

    Sievers, Peter

    2012-12-07

    show a good agreement. Up to now the measurements of impinging spectra with a Timepix detector have been performed in radiation fields with a relatively high fluence. To cope with the requirement of measuring in radiation fields with a low fluence, there had to be changes in the method of analysis compared to those performed formerly. An important improvement in this context was the employment of the Bayesian deconvolution method. The spectra reconstructed with this method were then compared to the results of two different and established detection systems. Firstly, the shape of the deconvolved spectrum was compared to the one measured with a hpGe detector. Secondly, the calculated value of the kerma rate was compared to the one measured with an ionization chamber. This gave an estimate on the correctness of the absolute number of photons. Both comparisons have shown a good agreement and thus I was able to validate that the method delivers precise results. Compared to the formerly used spectrum-stripping method the Bayesian deconvolution turned out to be very stable and reliable. This robustness of the deconvolution method and the development of a pixel-by-pixel energy calibration were the keys towards position-resolved spectrometry. With such a precise energy calibration the energy resolution was enhanced by up to 45%. This improved accuracy in the measurement has been very demanding on the improvements of the simulation of the response matrix needed for deconvolution. Both this enhanced simulation and a pixel-by-pixel calibrated detector opened the possibility of measuring the anode heel effect. Not only the relative angular dependency of the spectrum emitted but also the change in the absolute photon fluence were measured. Furthermore, it is possible to even use small ROIs down to 4x4 pixels to evaluate a spectrum. This was then applied for the spectrometry of small focal spots of a miniature X-ray source used in therapeutics. Furthermore, the robustness and the

  6. Resolving Signals to Cohesion: Two Models of Bridging Inference.

    Science.gov (United States)

    Hegarty, Mary; Revlin, Russell

    1999-01-01

    Suggests two models of how readers create bridging inferences to resolve signals to textual cohesion. Evaluates reading times, verification accuracy, verification latency, and regressive eye fixations to support the model which views bridges as the result of a form of deduction in which the reader tacitly establishes premises that provide rational…

  7. An Initial Investigation of Active Galaxies in RESOLVE and ECO

    Science.gov (United States)

    Norman, Dara J.; Kannappan, Sheila; Bittner, Ashley; Yarber, Aara'L.; Hoversten, Erik A.; Stark, David; RESOLVE Team

    2016-01-01

    The volume-limited REsolved Spectroscopy Of a Local VolumE (RESOLVE) survey and its complementary Environmental COntext (ECO) catalog are dominated by low mass, gas-rich galaxies, as is typical of the bulk of large-scale structure in the local universe. These surveys, therefore, provide an excellent opportunity to investigate the complete large-scale environments of low-redshift AGN and nuclear starbursts in such galaxies, in order to search for external triggering, examine activity in relation to gas supply, and investigate the role of feedback. By data-mining multi-wavelength catalogs that use varied techniques, we identify known AGN in RESOLVE and ECO, including a population of gas-dominated low-mass galaxies. We take advantage of these surveys' multi-wavelength supporting data to investigate triggering, feedback, and the roles of environment and gas supply in this initial sample of active galaxies. Because biases in standard AGN candidate selection techniques (e.g. BPT, X-ray luminosity) make them individually poor selectors of AGN activity in star-forming and low mass (<10^10 Msun) host galaxies, we also seek to improve the identification of nuclear activity in such galaxies via combined analysis of star formation and AGN signatures. RESOLVE is supported by NSF grant AST-0955368

  8. Nested Genetic Algorithm for Resolving Overlapped Spectral Bands

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A nested genetic algorithm, including genetic parameter level and genetic implemented level for peak parameters, was proposed and applied for resolving overlapped spectral bands. By the genetic parameter level, parameters of genetic algorithm were optimized; moreover, the number of overlapped peaks was determined simultaneously. Then parameters of individual peaks were computed with the genetic implemented level.

  9. 30 CFR 705.19 - Resolving prohibited interests.

    Science.gov (United States)

    2010-07-01

    ... the employee's statement and any other information pertinent to the Director's determination... INTERIOR GENERAL RESTRICTION ON FINANCIAL INTERESTS OF STATE EMPLOYEES § 705.19 Resolving prohibited... effect resolution. If an employee has a prohibited financial interest, the Head of the State...

  10. 30 CFR 706.19 - Resolving prohibited interests.

    Science.gov (United States)

    2010-07-01

    ... certified true copy of the employee's statement and any other information pertinent to the Director... INTERIOR GENERAL RESTRICTION ON FINANCIAL INTERESTS OF FEDERAL EMPLOYEES § 706.19 Resolving prohibited interests. Actions to be taken by the Director, the heads of other Federal agencies, and the heads of...

  11. TRIZ based Interface Conflict Resolving Strategies for Modular Product Architectures

    NARCIS (Netherlands)

    Wits, Wessel W.; Vaneker, Tom H.J.

    2010-01-01

    In product development, the chosen product architecture often possesses characteristics of both modular and integral design. Within a modular architecture, a Function-Behavior-Structure (FBS) model has been applied to describe modules and their interfaces. To resolve emerging interface conflicts, se

  12. Magnetic Resonance Microscopy Spatially Resolved NMR Techniques and Applications

    CERN Document Server

    Codd, Sarah

    2008-01-01

    This handbook and ready reference covers materials science applications as well as microfluidic, biomedical and dental applications and the monitoring of physicochemical processes. It includes the latest in hardware, methodology and applications of spatially resolved magnetic resonance, such as portable imaging and single-sided spectroscopy. For materials scientists, spectroscopists, chemists, physicists, and medicinal chemists.

  13. Time-resolved terahertz spectroscopy of black silicon

    DEFF Research Database (Denmark)

    Porte, Henrik; Turchinovich, Dmitry; Jepsen, Peter Uhd;

    2010-01-01

    The ultrafast photoconductivity dynamics of black silicon is measured by time-resolved terahertz spectroscopy. Black silicon is produced by laser annealing of an a-Si:H film. We show that the decay time of the photoconductivity depends on the annealing method and fluence used in the production...

  14. Resolvent kernel for the Kohn Laplacian on Heisenberg groups

    Directory of Open Access Journals (Sweden)

    Neur Eddine Askour

    2002-07-01

    Full Text Available We present a formula that relates the Kohn Laplacian on Heisenberg groups and the magnetic Laplacian. Then we obtain the resolvent kernel for the Kohn Laplacian and find its spectral density. We conclude by obtaining the Green kernel for fractional powers of the Kohn Laplacian.

  15. Advances in Time-Resolved Tomographic Particle Image Velocimetry

    NARCIS (Netherlands)

    Lynch, K.P.

    2015-01-01

    This thesis details advanced developments in 3-D particle image velocimetry (PIV) based on the tomographic PIV technique, with an emphasis on time-resolved experiments. Tomographic PIV is a technique introduced in 2006 to measure the flow velocity in a three-dimensional volume. When measurements are

  16. Time-resolved luminescence from feldspars: New insight into fading

    DEFF Research Database (Denmark)

    Tsukamoto, S.; Denby, P.M.; Murray, A.S.;

    2006-01-01

    Time-resolved infrared optically stimulated luminescence (IR-OSL) signals of K- and Na-feldspar samples extracted from sediments were measured in UV, blue and red detection windows, using a fast photon counter and pulsed IR stimulation (lambda = 875 nm). We observe that the relative contribution ...

  17. Spectrally resolved femtosecond photon echo spectroscopy of astaxanthin

    Science.gov (United States)

    Kumar, Ajitesh; Karthick Kumar, S. K.; Gupta, Aditya; Goswami, Debabrata

    2011-08-01

    We have studied the coherence and population dynamics of Astaxanthin solution in methanol and acetonitrile by spectrally resolving their photon echo signals. Our experiments indicate that methanol has a much stronger interaction with the ultrafast dynamics of Astaxanthin in comparison to that of acetonitrile.

  18. Music Education Preservice Teachers' Confidence in Resolving Behavior Problems

    Science.gov (United States)

    Hedden, Debra G.

    2015-01-01

    The purpose of this study was to investigate whether there would be a change in preservice teachers' (a) confidence concerning the resolution of behavior problems, (b) tactics for resolving them, (c) anticipation of problems, (d) fears about management issues, and (e) confidence in methodology and pedagogy over the time period of a one-semester…

  19. Resolving Semantic Interference during Word Production Requires Central Attention

    Science.gov (United States)

    Kleinman, Daniel

    2013-01-01

    The semantic picture-word interference task has been used to diagnose how speakers resolve competition while selecting words for production. The attentional demands of this resolution process were assessed in 2 dual-task experiments (tone classification followed by picture naming). In Experiment 1, when pictures and distractor words were presented…

  20. The far-infrared properties of spatially resolved AKARI observations

    NARCIS (Netherlands)

    Jeong, Woong-Seob; Nakagawa, Takao; Yamamura, Issei; Pearson, Chris P.; Savage, Richard S.; Lee, Hyung Mok; Shibai, Hiroshi; Makiuti, Sin'itirou; Baba, Hajime; Barthel, Peter; Clements, Dave; Doi, Yasuo; Figueredo, Elysandra; Goto, Tomotsugu; Hasegawa, Sunao; Kaneda, Hidehiro; Kawada, Mitsunobu; Kawamura, Akiko; Kester, Do; Kwon, Suk Minn; Matsuhara, Hideo; Matsuura, Shuji; Murakami, Hiroshi; Oh, Sang Hoon; Oliver, Sebastian; Pak, Soojong; Park, Yong-Sun; Serjeant, Stephen; Shirahata, Mai; Sohn, Jungjoo; Takagi, Toshinobu.; Wang, Lingyu; White, Glenn J.; Yamauchi, Chisato

    2007-01-01

    We present spatially resolved observations of IRAS sources from the Japanese infrared astronomy satellite AKARI All-Sky Survey during the performance verification phase of the mission. We extracted reliable point sources matched with the IRAS point source catalogue. By comparing IRAS and AKARI fluxe

  1. Path-length-resolved optical Doppler perfusion monitoring

    NARCIS (Netherlands)

    Varghese, Babu; Rajan, Vinayakrishnan; Leeuwen, van Ton G.; Steenbergen, Wiendelt

    2007-01-01

    We report the first path-length-resolved perfusion measurements on human skin measured with a phase-modulated low-coherence Mach-Zehnder interferometer with spatially separated fibers for illumination and detection. Optical path lengths of Doppler shifted and unshifted light and path-length-dependen

  2. Optimizing a time-resolved X-ray absorption experiment

    CERN Document Server

    Bressler, C; Chergui, M; Abela, R; Pattison, P

    2001-01-01

    Calculations are presented of the optimum conditions for performing a laser-pump X-ray probe time-resolved X-ray absorption experiment. The results concerning sensitivity and feasibility for implementing the method are illustrated for the case of the nascent I radical environment following I sup - photolysis in H sub 2 O.

  3. Retrieving the susceptibility from time-resolved terahertz experiments

    NARCIS (Netherlands)

    Schins, J.M.; Hendry, E.; Bonn, M.; Muller, H.G.

    2007-01-01

    We present an analytical expression for the observed signal in time- and phase-resolved pump-probe studies, with particular emphasis on terahertz time-domain spectroscopy. Maxwell’s equations are solved for the response of damped, harmonic oscillators to a driving probe field in the perturbative reg

  4. Spitzer IRAC observations of newly-discovered planetary nebulae from the Macquarie-AAO-Strasbourg H-alpha Planetary Nebula Project

    CERN Document Server

    Cohen, Martin; Green, Anne J; Murphy, Tara; Miszalski, Brent; Frew, David J; Meade, Marilyn R; Babler, Brian; Indebetouw, Remy; Whitney, Barbara A; Watson, Christer; Churchwell, Edward B; Watson, Douglas F

    2007-01-01

    We compare H-alpha, radio continuum, and Spitzer Space Telescope (SST) images of 58 planetary nebulae (PNe) recently discovered by the Macquarie-AAO-Strasbo- urg H-alpha PN Project (MASH) of the SuperCOSMOS H-alpha Survey. Using InfraRed Array Camera (IRAC) data we define the IR colors of PNe and demonstrate good isolation between these colors and those of many other types of astronomical object. The only substantive contamination of PNe in the color-color plane we illustrate is due to YSOs. However, this ambiguity is readily resolved by the unique optical characteristics of PNe and their environs. We also examine the relationships between optical and MIR morphologies from 3.6 to 8.0um and explore the ratio of mid-infrared (MIR) to radio nebular fluxes, which is a valuable discriminant between thermal and nonthermal emission. MASH emphasizes late evolutionary stages of PNe compared with previous catalogs, enabling study of the changes in MIR and radio flux that attend the aging process. Spatially integrated M...

  5. Lema\\^itre and Hubble: What was discovered - if any - in 1927-29?

    CERN Document Server

    Chernin, A D

    2011-01-01

    The Big Bang predicted theoretically by Friedmann could not be discovered in the 1920th, since global cosmological distances (more than 300-1000 Mpc) were not available for observations at that time. In 1927-29, Lema\\^itre and Hubble studied receding motions of galaxies at local distances of less than 20-30 Mpc and found that the motions followed the (nearly) linear velocity-distance relation, known now as Hubble's law. For decades, the real nature of this phenomenon has remained a mystery, in Sandage's words. After the discovery of dark energy, it was suggested that the dynamics of local expansion flows is dominated by omnipresent dark energy, and it is the dark energy antigravity that is able to introduce the linear velocity-distance relation to the flows. It implies that Hubble's law observed at local distances was in fact the first observational manifestation of dark energy. If this is the case, the commonly accepted criteria of scientific discovery lead to the conclusion: In 1927, Lema\\^itre discovered d...

  6. Searching for Dark Matter Annihilation in Recently Discovered Milky Way Satellites with Fermi-LAT

    CERN Document Server

    Fermi-LAT, The; Anderson, B; Bechtol, K; Drlica-Wagner, A; Meyer, M; Sanchez-Conde, M; Strigari, L; Wood, M; Abbott, T M C; Abdalla, F B; Benoit-Levy, A; Bernstein, G M; Bernstein, R A; Bertin, E; Brooks, D; Burke, D L; Rosell, A Carnero; Kind, M Carrasco; Carretero, J; Crocce, M; Cunha, C E; D'Andrea, C B; da Costa, L N; Desai, S; Diehl, H T; Dietrich, J P; Doel, P; Eifler, T F; Evrard, A E; Neto, A Fausti; Finley, D A; Flaugher, B; Fosalba, P; Frieman, J; Gerdes, D W; Goldstein, D A; Gruen, D; Gruendl, R A; Honscheid, K; James, D J; Kent, S; Kuehn, K; Kuropatkin, N; Lahav, O; Li, T S; Maia, M A G; March, M; Marshall, J L; Martini, P; Miller, C J; Miquel, R; Neilsen, E; Nord, B; Ogando, R; Plazas, A A; Reil, K; Romer, A K; Rykoff, E S; Sanchez, E; Santiago, B; Schubnell, M; Sevilla-Noarbe, I; Smith, R C; Soares-Santos, M; Sobreira, F; Suchyta, E; Swanson, M E C; Tarle, G; Vikram, V; Walker, A R; Wechsler, R H

    2016-01-01

    We search for excess gamma-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using 6 years of data from the Fermi Large Area Telescope (LAT). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted gamma-ray flux due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are dark-matter-dominated dSphs. LAT data coincident with four of the newly discovered targets show a slight preference (each ~$2 \\sigma$ local) for gamma-ray emission in excess of the background. However, the ensemble of derived gamma-ray flux upper limits for individual targets is consistent with the expectation from analyzing random blank-sk...

  7. Eight gamma-ray pulsars discovered in blind frequency searches of Fermi LAT data

    CERN Document Server

    Parkinson, P M Saz; Ziegler, M; Ray, P S; Abdo, A A; Ballet, J; Baring, M G; Belfiore, A; Burnett, T H; Caliandro, G A; Camilo, F; Caraveo, P A; de Luca, A; Ferrara, E C; Freire, P C C; Grove, J E; Gwon, C; Harding, A K; Johnson, R P; Johnson, T J; Johnston, S; Keith, M; Kerr, M; Knödlseder, J; Makeev, A; Marelli, M; Michelson, P F; Parent, D; Ransom, S M; Reimer, O; Romani, R W; Smith, D A; Thompson, D J; Watters, K; Weltevrede, P; Wolff, M T; Wood, K S

    2010-01-01

    We report the discovery of eight gamma-ray pulsars in blind frequency searches using the LAT, onboard the Fermi Gamma-ray Space Telescope. Five of the eight pulsars are young (tau_c10^36 erg/s), and located within the Galactic plane (|b|<3 deg). The remaining three are older, less energetic, and located off the plane. Five pulsars are associated with sources included in the LAT bright gamma-ray source list, but only one, PSR J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the smallest characteristic age (tau_c=4.6 kyr) and is the most energetic (Edot=1.1E37 erg/s) of all gamma-ray pulsars discovered so far in blind searches. PSRs J1957+5033 and J2055+25 have the largest characteristic ages (tau_c~1 Myr) and are the least energetic (Edot~5E33 erg/s) of the newly-discovered pulsars. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. In ...

  8. Phenomena Discovered During Immersion of Steel Parts into Liquid Quenchants (Overview)

    Science.gov (United States)

    Kobasko, Nikolai I.

    2014-12-01

    In the paper, new phenomena are discussed which were discovered during investigation of the intensive quenching processes. It is shown that in many cases film boiling is prevented completely during quenching of steel parts in cold liquids, especially in water salt solutions. In this case, the part surface temperature drops almost immediately to the liquid boiling point at the beginning of the quench and then maintains at this level for a relatively long time, i.e., the so-called self-regulated thermal process is established. A simple equation for determining the duration of the self-regulated thermal process is proposed. Thermal waves are generated during an immersion of steel parts into a cold liquid and after the self-regulated thermal process is completed. The thermal waves move in opposite direction from where the cooling process starts. The self-regulated thermal process was used to develop an original intensive quenching technology (IQ-2 process). It can be a basis for developing other new technologies such as an austempering and a martempering in cold liquids under pressure. Discovered effects of thermal waves can be used for determining a duration of the self-regulated thermal process and for reconstructing an existing theory on the double electrical layer. Practical examples of calculations of the duration of the self-regulated thermal process are provided in the paper.

  9. A New Species of Frog (Anura: Dicroglossidae) Discovered from the Mega City of Dhaka.

    Science.gov (United States)

    Howlader, Mohammad Sajid Ali; Nair, Abhilash; Merilä, Juha

    2016-01-01

    We describe a new species of frog of the genus Zakerana discovered from the urban core of Dhaka, Bangladesh, one of the most densely populated cities in the world. Although the new species is morphologically similar to the geographically proximate congeners in the Bangladeshi cricket frog group, we show that it can be distinguished from all congeners on the basis of morphological characters, advertisement calls and variation in two mitochondrial DNA genes (12S rRNA and 16S rRNA). Apart from several diagnostic differences in body proportions, the new species differs from other Zakerana species in having a flattened snout (from ventral view) projecting over the lower jaw, and diagnostic trapezoid-shaped red markings on the vocal sac in males. Molecular genetic analyses show that the new species is highly divergent (3.1-20.1% sequence divergence) from all congeneric species, and forms a well-supported clade with its sister species, Zakerana asmati. The discovery of a new amphibian species from the urban core of Dhaka together with several recent descriptions of new amphibian species from Bangladesh may indicate that more amphibian species remain to be discovered from this country.

  10. Discovering Recurrent Copy Number Aberrations in Complex Patterns via Non-Negative Sparse Singular Value Decomposition.

    Science.gov (United States)

    Xi, Jianing; Li, Ao

    2016-01-01

    Recurrent copy number aberrations (RCNAs) in multiple cancer samples are strongly associated with tumorigenesis, and RCNA discovery is helpful to cancer research and treatment. Despite the emergence of numerous RCNA discovering methods, most of them are unable to detect RCNAs in complex patterns that are influenced by complicating factors including aberration in partial samples, co-existing of gains and losses and normal-like tumor samples. Here, we propose a novel computational method, called non-negative sparse singular value decomposition (NN-SSVD), to address the RCNA discovering problem in complex patterns. In NN-SSVD, the measurement of RCNA is based on the aberration frequency in a part of samples rather than all samples, which can circumvent the complexity of different RCNA patterns. We evaluate NN-SSVD on synthetic dataset by comparison on detection scores and Receiver Operating Characteristics curves, and the results show that NN-SSVD outperforms existing methods in RCNA discovery and demonstrate more robustness to RCNA complicating factors. Applying our approach on a breast cancer dataset, we successfully identify a number of genomic regions that are strongly correlated with previous studies, which harbor a bunch of known breast cancer associated genes.

  11. VLT/MUSE discovers a jet from the evolved B[e] star MWC 137

    CERN Document Server

    Mehner, A; Groh, J H; Oudmaijer, R D; Baade, D; Rivinius, T; Selman, F; Boffin, H M J; Martayan, C

    2016-01-01

    Not all stars exhibiting the optical spectral characteristics of B[e] stars share the same evolutionary stage. The Galactic B[e] star MWC 137 is a prime example of an object with uncertain classification, with previous work suggesting pre- and post-main sequence classification. Our goal is to settle this debate and provide reliable evolutionary classification. Integral field spectrograph observations with VLT MUSE of the cluster SH 2-266 are used to analyze the nature of MWC 137. A collimated outflow is discovered that is geometrically centered on MWC 137. The central position of MWC 137 in the cluster SH 2-266 within the larger nebula suggests strongly that it is a member of this cluster and that it is both at the origin of the nebula and the newly discovered jet. Comparison of the color-magnitude diagram of the brightest cluster stars with stellar evolutionary models results in a distance of about 5.2$\\pm$1.4 kpc. We estimate that the cluster is at least 3 Myr old. The jet extends over 66" (1.7 pc) projecte...

  12. Discovering a First-Order Phase Transition in the Li-CeO2 System.

    Science.gov (United States)

    Li, Kaikai; Zhou, Xiaoye; Nie, Anmin; Sun, Sheng; He, Yan-Bing; Ren, Wei; Li, Baohua; Kang, Feiyu; Kim, Jang-Kyo; Zhang, Tong-Yi

    2017-02-08

    An in-depth understanding of (de)lithiation induced phase transition in electrode materials is crucial to grasp their structure-property relationships and provide guidance to the design of more desirable electrodes. By operando synchrotron XRD (SXRD) measurement and Density Functional Theory (DFT) based calculations, we discover a reversible first-order phase transition for the first time during (de)lithiation of CeO2 nanoparticles. The LixCeO2 compound phase is identified to possess the same fluorite crystal structure with FM3M space group as that of the pristine CeO2 nanoparticles. The SXRD determined lattice constant of the LixCeO2 compound phase is 0.551 nm, larger than that of 0.541 nm of the pristine CeO2 phase. The DFT calculations further reveal that the Li induced redistribution of electrons causes the increase in the Ce-O covalent bonding, the shuffling of Ce and O atoms, and the jump expansion of lattice constant, thereby resulting in the first-order phase transition. Discovering the new phase transition throws light upon the reaction between lithium and CeO2, and provides opportunities to the further investigation of properties and potential applications of LixCeO2.

  13. Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds.

    Science.gov (United States)

    Zhang, Yanmin; Jiao, Yu; Xiong, Xiao; Liu, Haichun; Ran, Ting; Xu, Jinxing; Lu, Shuai; Xu, Anyang; Pan, Jing; Qiao, Xin; Shi, Zhihao; Lu, Tao; Chen, Yadong

    2015-11-01

    The discovery of novel scaffolds against a specific target has long been one of the most significant but challengeable goals in discovering lead compounds. A scaffold that binds in important regions of the active pocket is more favorable as a starting point because scaffolds generally possess greater optimization possibilities. However, due to the lack of sufficient chemical space diversity of the databases and the ineffectiveness of the screening methods, it still remains a great challenge to discover novel active scaffolds. Since the strengths and weaknesses of both fragment-based drug design and traditional virtual screening (VS), we proposed a fragment VS concept based on Bayesian categorization for the discovery of novel scaffolds. This work investigated the proposal through an application on VEGFR-2 target. Firstly, scaffold and structural diversity of chemical space for 10 compound databases were explicitly evaluated. Simultaneously, a robust Bayesian classification model was constructed for screening not only compound databases but also their corresponding fragment databases. Although analysis of the scaffold diversity demonstrated a very unevenly distribution of scaffolds over molecules, results showed that our Bayesian model behaved better in screening fragments than molecules. Through a literature retrospective research, several generated fragments with relatively high Bayesian scores indeed exhibit VEGFR-2 biological activity, which strongly proved the effectiveness of fragment VS based on Bayesian categorization models. This investigation of Bayesian-based fragment VS can further emphasize the necessity for enrichment of compound databases employed in lead discovery by amplifying the diversity of databases with novel structures.

  14. Macrofaunal communites at newly discovered hydrothermal fields in Central Indian Ridge

    Science.gov (United States)

    Miyazaki, J.; Takai, K.; Nakamura, K.; Watanabe, H.; Noguchi, T.; Matsuzaki, T.; Watsuji, T.; Nemoto, S.; Kawagucci, S.; Shibuya, T.; Okamura, K.; Mochizuki, M.; Orihashi, Y.; Marie, D.; Koonjul, M.; Singh, M.; Beedessee, G.; Bhikajee, M.; Tamaki, K.

    2010-12-01

    In YK09-13 Leg1 cruise targeted on the segment 15 and 16 in Central Indian Ridge (CIR), we have successfully discovered two hydrothermal fields, DODO field and Solitaire field. We expected that there were unique macrofaunal communities in these hydrothermal fields, because there was in Kairei field on the segment 1 in CIR. Particularly, a gastropod, “scaly-foot”, which has sclerites covered with iron-sulfide has only discovered in Kairei field. Therefore, it was interesting whether this unique scaly-foot only exists in Kairei fields or widely expands in CIR. In DODO fields, there were 10 to 15 active chimneys. However, very few hydrothermal vent-endemic faunas were observed. We observed only crabs and shrimps but we did not found shells. As opposed to in the Dodo field, biomass and composition of macrofaunal communities were highly prosperous in the Solitaire field, being equal to Kairei field. Although we have an only one dive to explore the Solitaire field, many predominant taxa were sampled and observed, for example, Alviniconcha, mussels, vanacles and so on. However, the most outstanding feature was the presence of a new morphotype of ‘scaly-foot’ gastropod. Discovery of this new-morphytpe ‘scary-foot” disproved our knowledge. In this conference, I will present these observations. Especially characterization of two types of scaly-foot (Kairei-type and Solitaire-type) will be focused.

  15. 2MASSJ22560844+5954299: the newly discovered cataclysmic star with the deepest eclipse

    CERN Document Server

    Kjurkchieva, D; Dimitrov, D; Groebel, R; Ibryamov, S; Nikolov, G

    2015-01-01

    Context: The SW Sex stars are assumed to represent a distinguished stage in CV evolution, making it especially important to study them. Aims: We discovered a new cataclysmic star and carried out prolonged and precise photometric observations, as well as medium-resolution spectral observations. Modelling these data allowed us to determine the psysical parameters and to establish its peculiarities. Results: The newly discovered vataclysmic variable 2MASSJ22560844+5954299 shows the deepest eclipse amongst the known nova-like stars. It was reproduced by totally covering a very luminous accretion disk by a red secondary component. The temperature distribution of the disk is flatter than that of steady-state disk. The target is unusual with the combination of a low mass ratio q~1.0 (considerably below the limit q=1.2 of stable mass transfer of CVs) and an M-star secondary. The intensity of the observed three emission lines, H_alpha, He 5875, and He 6678, sharply increases around phase 0.0, accompanied by a Doppler ...

  16. Discovering intrinsic properties of human observers' visual search and mathematical observers' scanning.

    Science.gov (United States)

    He, Xin; Samuelson, Frank; Zeng, Rongping; Sahiner, Berkman

    2014-11-01

    There is a lack of consensus in measuring observer performance in search tasks. To pursue a consensus, we set our goal to obtain metrics that are practical, meaningful, and predictive. We consider a metric practical if it can be implemented to measure human and computer observers' performance. To be meaningful, we propose to discover intrinsic properties of search observers and formulate the metrics to characterize these properties. If the discovered properties allow verifiable predictions, we consider them predictive. We propose a theory and a conjecture toward two intrinsic properties of search observers: rationality in classification as measured by the location-known-exactly (LKE) receiver operating characteristic (ROC) curve and location uncertainty as measured by the effective set size (M*). These two properties are used to develop search models in both single-response and free-response search tasks. To confirm whether these properties are "intrinsic," we investigate their ability in predicting search performance of both human and scanning channelized Hotelling observers. In particular, for each observer, we designed experiments to measure the LKE-ROC curve and M*, which were then used to predict the same observer's performance in other search tasks. The predictions were then compared to the experimentally measured observer performance. Our results indicate that modeling the search performance using the LKE-ROC curve and M* leads to successful predictions in most cases.

  17. A Network Biology Approach to Discover the Molecular Biomarker Associated with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Liwei Zhuang

    2014-01-01

    Full Text Available In recent years, high throughput technologies such as microarray platform have provided a new avenue for hepatocellular carcinoma (HCC investigation. Traditionally, gene sets enrichment analysis of survival related genes is commonly used to reveal the underlying functional mechanisms. However, this approach usually produces too many candidate genes and cannot discover detailed signaling transduction cascades, which greatly limits their clinical application such as biomarker development. In this study, we have proposed a network biology approach to discover novel biomarkers from multidimensional omics data. This approach effectively combines clinical survival data with topological characteristics of human protein interaction networks and patients expression profiling data. It can produce novel network based biomarkers together with biological understanding of molecular mechanism. We have analyzed eighty HCC expression profiling arrays and identified that extracellular matrix and programmed cell death are the main themes related to HCC progression. Compared with traditional enrichment analysis, this approach can provide concrete and testable hypothesis on functional mechanism. Furthermore, the identified subnetworks can potentially be used as suitable targets for therapeutic intervention in HCC.

  18. Discovering free energy basins for macromolecular systems via guided multiscale simulation.

    Science.gov (United States)

    Sereda, Yuriy V; Singharoy, Abhishek B; Jarrold, Martin F; Ortoleva, Peter J

    2012-07-26

    An approach for the automated discovery of low free energy states of macromolecular systems is presented. The method does not involve delineating the entire free energy landscape but proceeds in a sequential free energy minimizing state discovery; i.e., it first discovers one low free energy state and then automatically seeks a distinct neighboring one. These states and the associated ensembles of atomistic configurations are characterized by coarse-grained variables capturing the large-scale structure of the system. A key facet of our approach is the identification of such coarse-grained variables. Evolution of these variables is governed by Langevin dynamics driven by thermal-average forces and mediated by diffusivities, both of which are constructed by an ensemble of short molecular dynamics runs. In the present approach, the thermal-average forces are modified to account for the entropy changes following from our knowledge of the free energy basins already discovered. Such forces guide the system away from the known free energy minima, over free energy barriers, and to a new one. The theory is demonstrated for lactoferrin, known to have multiple energy-minimizing structures. The approach is validated using experimental structures and traditional molecular dynamics. The method can be generalized to enable the interpretation of nanocharacterization data (e.g., ion mobility-mass spectrometry, atomic force microscopy, chemical labeling, and nanopore measurements).

  19. Fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity

    OpenAIRE

    Panayotidis, Costas; Foidart, Jean-Michel; Nisolle, Michelle

    2008-01-01

    This article presents for the first time in the literature a case of fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity. Peer reviewed

  20. Time-resolved and position-resolved X-ray spectrometry with a pixelated detector

    Energy Technology Data Exchange (ETDEWEB)

    Sievers, Peter

    2012-12-07

    show a good agreement. Up to now the measurements of impinging spectra with a Timepix detector have been performed in radiation fields with a relatively high fluence. To cope with the requirement of measuring in radiation fields with a low fluence, there had to be changes in the method of analysis compared to those performed formerly. An important improvement in this context was the employment of the Bayesian deconvolution method. The spectra reconstructed with this method were then compared to the results of two different and established detection systems. Firstly, the shape of the deconvolved spectrum was compared to the one measured with a hpGe detector. Secondly, the calculated value of the kerma rate was compared to the one measured with an ionization chamber. This gave an estimate on the correctness of the absolute number of photons. Both comparisons have shown a good agreement and thus I was able to validate that the method delivers precise results. Compared to the formerly used spectrum-stripping method the Bayesian deconvolution turned out to be very stable and reliable. This robustness of the deconvolution method and the development of a pixel-by-pixel energy calibration were the keys towards position-resolved spectrometry. With such a precise energy calibration the energy resolution was enhanced by up to 45%. This improved accuracy in the measurement has been very demanding on the improvements of the simulation of the response matrix needed for deconvolution. Both this enhanced simulation and a pixel-by-pixel calibrated detector opened the possibility of measuring the anode heel effect. Not only the relative angular dependency of the spectrum emitted but also the change in the absolute photon fluence were measured. Furthermore, it is possible to even use small ROIs down to 4x4 pixels to evaluate a spectrum. This was then applied for the spectrometry of small focal spots of a miniature X-ray source used in therapeutics. Furthermore, the robustness and the

  1. Discovering structural motifs using a structural alphabet: Application to magnesium-binding sites

    Directory of Open Access Journals (Sweden)

    Lim Carmay

    2007-03-01

    Full Text Available Abstract Background For many metalloproteins, sequence motifs characteristic of metal-binding sites have not been found or are so short that they would not be expected to be metal-specific. Striking examples of such metalloproteins are those containing Mg2+, one of the most versatile metal cofactors in cellular biochemistry. Even when Mg2+-proteins share insufficient sequence homology to identify Mg2+-specific sequence motifs, they may still share similarity in the Mg2+-binding site structure. However, no structural motifs characteristic of Mg2+-binding sites have been reported. Thus, our aims are (i to develop a general method for discovering structural patterns/motifs characteristic of ligand-binding sites, given the 3D protein structures, and (ii to apply it to Mg2+-proteins sharing 2+-structural motifs are identified as recurring structural patterns. Results The structural alphabet-based motif discovery method has revealed the structural preference of Mg2+-binding sites for certain local/secondary structures: compared to all residues in the Mg2+-proteins, both first and second-shell Mg2+-ligands prefer loops to helices. Even when the Mg2+-proteins share no significant sequence homology, some of them share a similar Mg2+-binding site structure: 4 Mg2+-structural motifs, comprising 21% of the binding sites, were found. In particular, one of the Mg2+-structural motifs found maps to a specific functional group, namely, hydrolases. Furthermore, 2 of the motifs were not found in non metalloproteins or in Ca2+-binding proteins. The structural motifs discovered thus capture some essential biochemical and/or evolutionary properties, and hence may be useful for discovering proteins where Mg2+ plays an important biological role. Conclusion The structural motif discovery method presented herein is general and can be applied to any set of proteins with known 3D structures. This new method is timely considering the increasing number of structures for

  2. Discover Our Earth: Web-Based Geophysical Data in the Classroom

    Science.gov (United States)

    Moore, A.; Seber, D.; Danowski, D.; Brindisi, C.

    2002-12-01

    Discover Our Earth is a web-based system designed for classroom use, allowing access and display of geospatial data sets . It is an education and outreach module built as part of Cornell University's Geoscience Information System, originally constructed as a tool for geophysical research (http://atlas.geo.cornell.edu). Discover Our Earth has been used in university, high school and middle school classrooms. Working with real data is a powerful tool for helping students learn scientific principles, content, and the processes of scientific inquiry. In order to give students access to data that is otherwise difficult to work with, Discover Our Earth is comprised of several elements. The central component is a Java applet called QUEST (Quick Use Earth Study Tool). QUEST allows students to query and display data from three data sets selected from the 100+ housed within the Information System. Any attribute of earthquake, volcano, or topographic data can be selected and displayed, and multiple data sets can be overlain on each other, or on assorted background images (such as a geographic base map, age of the sea floor etc). Each image is saved in the QUEST history window, allowing students to compare multiple selections, or to animate a series of images as a "filmstrip." In order to help students better understand their results, the QUEST applet is supported by several other components. There are guides for both teacher and student. The student guide gives step-by-step instructions for a series of problems, and suggests others that will help students answer questions of local and global interest. The teacher guide provides background material, context, and answers to the student exercises. There are animations and 3-D visualizations that allow students to better interpret their maps. Additionally, there are interactive experiments on topics such as continental drift, isostasy, viscosity, that allow students to explore the physics that underlie the processes they are

  3. De novo assembly of a haplotype-resolved human genome.

    Science.gov (United States)

    Cao, Hongzhi; Wu, Honglong; Luo, Ruibang; Huang, Shujia; Sun, Yuhui; Tong, Xin; Xie, Yinlong; Liu, Binghang; Yang, Hailong; Zheng, Hancheng; Li, Jian; Li, Bo; Wang, Yu; Yang, Fang; Sun, Peng; Liu, Siyang; Gao, Peng; Huang, Haodong; Sun, Jing; Chen, Dan; He, Guangzhu; Huang, Weihua; Huang, Zheng; Li, Yue; Tellier, Laurent C A M; Liu, Xiao; Feng, Qiang; Xu, Xun; Zhang, Xiuqing; Bolund, Lars; Krogh, Anders; Kristiansen, Karsten; Drmanac, Radoje; Drmanac, Snezana; Nielsen, Rasmus; Li, Songgang; Wang, Jian; Yang, Huanming; Li, Yingrui; Wong, Gane Ka-Shu; Wang, Jun

    2015-06-01

    The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome shotgun strategies, based solely on next-generation sequencing and hierarchical assembly methods. We applied our sequencing method to the genome of an Asian individual and generated a 5.15-Gb assembled genome with a haplotype N50 of 484 kb. Our analysis identified previously undetected indels and 7.49 Mb of novel coding sequences that could not be aligned to the human reference genome, which include at least six predicted genes. This haplotype-resolved genome represents the most complete de novo human genome assembly to date. Application of our approach to identify individual haplotype differences should aid in translating genotypes to phenotypes for the development of personalized medicine.

  4. Spatially resolved remote measurement of temperature by neutron resonance absorption

    Energy Technology Data Exchange (ETDEWEB)

    Tremsin, A.S., E-mail: ast@ssl.berkeley.edu [Space Sciences Laboratory, University of California at Berkeley, 7 Gauss Way, Berkeley, CA 94720 (United States); Kockelmann, W.; Pooley, D.E. [STFC, Rutherford Appleton Laboratory, ISIS Facility, Didcot OX11 0QX (United Kingdom); Feller, W.B. [NOVA Scientific, Inc., 10 Picker Road, Sturbridge, MA 01566 (United States)

    2015-12-11

    Deep penetration of neutrons into most engineering materials enables non-destructive studies of their bulk properties. The existence of sharp resonances in neutron absorption spectra enables isotopically-resolved imaging of elements present in a sample, as demonstrated by previous studies. At the same time the Doppler broadening of resonance peaks provides a method of remote measurement of temperature distributions within the same sample. This technique can be implemented at a pulsed neutron source with a short initial pulse allowing for the measurement of the energy of each registered neutron by the time of flight technique. A neutron counting detector with relatively high timing and spatial resolution is used to demonstrate the possibility to obtain temperature distributions across a 100 µm Ta foil with ~millimeter spatial resolution. Moreover, a neutron transmission measurement over a wide energy range can provide spatially resolved sample information such as temperature, elemental composition and microstructure properties simultaneously.

  5. Resolving fundamental limits of adhesive bonding in microfabrication.

    Energy Technology Data Exchange (ETDEWEB)

    Hall, Jessica S.; Frischknecht, Amalie Lucile; Emerson, John Allen; Adkins, Douglas Ray; Kent, Michael Stuart; Read, Douglas H.; Giunta, Rachel Knudsen; Lamppa, Kerry P.; Kawaguchi, Stacie; Holmes, Melissa A.

    2004-04-01

    As electronic and optical components reach the micro- and nanoscales, efficient assembly and packaging require the use of adhesive bonds. This work focuses on resolving several fundamental issues in the transition from macro- to micro- to nanobonding. A primary issue is that, as bondline thicknesses decrease, knowledge of the stability and dewetting dynamics of thin adhesive films is important to obtain robust, void-free adhesive bonds. While researchers have studied dewetting dynamics of thin films of model, non-polar polymers, little experimental work has been done regarding dewetting dynamics of thin adhesive films, which exhibit much more complex behaviors. In this work, the areas of dispensing small volumes of viscous materials, capillary fluid flow, surface energetics, and wetting have all been investigated. By resolving these adhesive-bonding issues, we are allowing significantly smaller devices to be designed and fabricated. Simultaneously, we are increasing the manufacturability and reliability of these devices.

  6. Probing Local Environments by Time-Resolved Stimulated Emission Spectroscopy

    Directory of Open Access Journals (Sweden)

    Ana Rei

    2012-01-01

    Full Text Available Time-resolved stimulated emission spectroscopy was employed to probe the local environment of DASPMI (4-(4-(dimethylaminostyryl-N-methyl-pyridinium iodide in binary solvents of different viscosity and in a sol-gel matrix. DASPMI is one of the molecules of choice to probe local environments, and the dependence of its fluorescence emission decay on viscosity has been previously used for this purpose in biological samples, solid matrices as well as in solution. The results presented in this paper show that time-resolved stimulated emission of DASPMI is a suitable means to probe the viscosity of local environments. Having the advantage of a higher time resolution, stimulated emission can provide information that is complementary to that obtained from fluorescence decay measurements, making it feasible to probe systems with lower viscosity.

  7. Resolving Rapid Variation in Energy for Particle Transport

    Energy Technology Data Exchange (ETDEWEB)

    Haut, Terry Scot [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Computer, Computational, and Statistical Sciences Division; Ahrens, Cory Douglas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Computer, Computational, and Statistical Sciences Division; Jonko, Alexandra [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Computer, Computational, and Statistical Sciences Division; Till, Andrew Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Computer, Computational, and Statistical Sciences Division; Lowrie, Robert Byron [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Computer, Computational, and Statistical Sciences Division

    2016-08-23

    Resolving the rapid variation in energy in neutron and thermal radiation transport is needed for the predictive simulation capability in high-energy density physics applications. Energy variation is difficult to resolve due to rapid variations in cross sections and opacities caused by quantized energy levels in the nuclei and electron clouds. In recent work, we have developed a new technique to simultaneously capture slow and rapid variations in the opacities and the solution using homogenization theory, which is similar to multiband (MB) and to the finite-element with discontiguous support (FEDS) method, but does not require closure information. We demonstrated the accuracy and efficiency of the method for a variety of problems. We are researching how to extend the method to problems with multiple materials and the same material but with different temperatures and densities. In this highlight, we briefly describe homogenization theory and some results.

  8. Resolving flows around black holes: numerical technique and applications

    CERN Document Server

    Curtis, Michael

    2015-01-01

    Black holes are believed to be one of the key ingredients of galaxy formation models, but it has been notoriously challenging to simulate them due to the very complex physics and large dynamical range of spatial scales involved. Here we address significant shortcomings of a Bondi-Hoyle-like prescription commonly invoked to estimate black hole accretion in cosmological hydrodynamic simulations of galaxy formation. We describe and implement a novel super-Lagrangian refinement scheme to increase, adaptively and 'on the fly', the mass and spatial resolution in targeted regions around the accreting black holes at limited computational cost. While our refinement scheme is generically applicable and flexible, for the purpose of this paper we select the smallest resolvable scales to match black holes' instantaneous Bondi radii, thus effectively resolving Bondi-Hoyle-like accretion in full galaxy formation simulations. This permits us to not only estimate gas properties close to the Bondi radius much more accurately, ...

  9. Polarization-resolved microscopy through scattering media via wavefront shaping

    CERN Document Server

    de Aguiar, Hilton B; Brasselet, Sophie

    2015-01-01

    Wavefront shaping has revolutionized imaging deep in scattering media, being able to spatially and temporally refocus light through or inside the medium. However, wavefront shaping is not compatible yet with polarization-resolved microscopy given the need of polarizing optics to refocus light with a controlled polarization state. Here, we show that wavefront shaping is not only able to restore a focus, but it can also recover the injected polarization state without using any polarizing optics at the detection. This counter-intuitive effect occurs up to several transport mean free path thick samples, which exhibit a speckle with a completely scrambled state. Remarkably, an arbitrary rotation of the input polarization does not degrade the quality of the focus. This unsupervised re-polarization - out of the originally scrambled polarization state - paves the way for polarization-resolved structural microscopy at unprecedented depths. We exploit this phenomenon and demonstrate second harmonic generation (SHG) str...

  10. A New Strategy to Discover Heavy Colored Vectors at the Early LHC

    CERN Document Server

    Vignaroli, Natascia

    2011-01-01

    We perform a study of the LHC discovery reach on a heavy gluon (G*) and heavy fermions (top and bottom excitations), coming from a new composite sector. We find that heavy fermion resonances have a great impact on the composite gluon phenomenology. If the composite gluon is heavier than composite fermions, as flavor observables seem to suggest, the search in the channel where G* decays into a heavy fermion plus its Standard Model partner is very promising, with the possibility for both the G* and heavy fermions to be discovered at the early stage of the LHC. The channel offers also the possibility to extract important information on model parameters, such as the top degree of compositeness.

  11. Mining a clinical data warehouse to discover disease-finding associations using co-occurrence statistics.

    Science.gov (United States)

    Cao, Hui; Markatou, Marianthi; Melton, Genevieve B; Chiang, Michael F; Hripcsak, George

    2005-01-01

    This paper applies co-occurrence statistics to discover disease-finding associations in a clinical data warehouse. We used two methods, chi2 statistics and the proportion confidence interval (PCI) method, to measure the dependence of pairs of diseases and findings, and then used heuristic cutoff values for association selection. An intrinsic evaluation showed that 94 percent of disease-finding associations obtained by chi2 statistics and 76.8 percent obtained by the PCI method were true associations. The selected associations were used to construct knowledge bases of disease-finding relations (KB-chi2, KB-PCI). An extrinsic evaluation showed that both KB-chi2 and KB-PCI could assist in eliminating clinically non-informative and redundant findings from problem lists generated by our automated problem list summarization system.

  12. Discovering potential user browsing behaviors using custom-built apriori algorithm

    CERN Document Server

    Rawat, Sandeep Singh

    2010-01-01

    Most of the organizations put information on the web because they want it to be seen by the world. Their goal is to have visitors come to the site, feel comfortable and stay a while and try to know completely about the running organization. As educational system increasingly requires data mining, the opportunity arises to mine the resulting large amounts of student information for hidden useful information (patterns like rule, clustering, and classification, etc). The education domain offers ground for many interesting and challenging data mining applications like astronomy, chemistry, engineering, climate studies, geology, oceanography, ecology, physics, biology, health sciences and computer science. Collecting the interesting patterns using the required interestingness measures, which help us in discovering the sophisticated patterns that are ultimately used for developing the site. We study the application of data mining to educational log data collected from Guru Nanak Institute of Technology, Ibrahimpatn...

  13. Discovering Performance Measurement System to Evaluate the Efficiency of E-Business Solutions

    Directory of Open Access Journals (Sweden)

    Laura Uturytė  -Vrubliauskienė

    2012-07-01

    Full Text Available Despite the significant growth of information technologies investments, evidence of their influence on organization performance remains inconclusive. Nowadays it is very important to realize whether expected economic benefits of information technologies investments are being recognized in organizations. Currently organizations can no longer afford basically to lose their money in e-business initiatives without developing and using suitable metrics to measure the effectiveness of such investments and to find out the relationship between e-business and organization performance. The study describes research aimed at determining the exact nature of such e-business performance measurement systems. The basic objective of this study is to discover performance measurement system for evaluating the efficiency of e-business solutions.Article in Lithuanian

  14. Discovering low-rank shared concept space for adapting text mining models.

    Science.gov (United States)

    Chen, Bo; Lam, Wai; Tsang, Ivor W; Wong, Tak-Lam

    2013-06-01

    We propose a framework for adapting text mining models that discovers low-rank shared concept space. Our major characteristic of this concept space is that it explicitly minimizes the distribution gap between the source domain with sufficient labeled data and the target domain with only unlabeled data, while at the same time it minimizes the empirical loss on the labeled data in the source domain. Our method is capable of conducting the domain adaptation task both in the original feature space as well as in the transformed Reproducing Kernel Hilbert Space (RKHS) using kernel tricks. Theoretical analysis guarantees that the error of our adaptation model can be bounded with respect to the embedded distribution gap and the empirical loss in the source domain. We have conducted extensive experiments on two common text mining problems, namely, document classification and information extraction, to demonstrate the efficacy of our proposed framework.

  15. Sequence Length Limits for Controlling False Positives in Discovering Nucleotide Sequence Motifs

    Institute of Scientific and Technical Information of China (English)

    CHEN Lei; QiAN Zi-liang

    2008-01-01

    In the study of motif discovery, especially the transcription factor DNA binding sites discovery, a too long input sequence would return non-informative motifs rather than those biological functional motifs. This paper gave theoretical analyses and computational experiments to suggest the length limits of the input sequence. When the sequence length exceeds a certain critical point, the probability of discovering the motif decreases sharply. The work not only gave an explanation on the unsatisfying results of the existed motif discovery problems that the input sequence length might be too long and exceed the point, but also provided an estimation of input sequence length we should accept to get more meaningful and reliable results in motif discovery.

  16. PTF discovers and follows-up nearby, young, Type II supernova

    Science.gov (United States)

    Kasliwal, M. M.; Quimby, R. M.; Ofek, E. O.; Kulkarni, S. R.; Gal-Yam, A.; Arcavi, I.; Green, Y.; Walker, E.; Mazzali, P.; Nugent, P. E.; Poznanski, D.; Howell, D. A.; Dilday, B.; Fox, D. B.

    2010-09-01

    On UT 2010 Sep 15.243, the Palomar Transient Factory discovered an optical transient, PTF10vdl at RA(J2000) = 23:05:49.001 and DEC(J2000)=03:31:20.50 near NGC 7483. We obtained Target Of Opportunity spectra with Gemini-S/GMOS (PI Kasliwal) on Sep 16.29. The spectrum was extremely blue (f_nu proportional to nu^4.5) and nearly featureless. We further obtained a spectrum with the TNG/DOLORES (PI Walker) on Sep 17.40 and P-Cygni profiles of four Balmer lines were clearly visible, consistent with the redshift of NGC 7483, suggesting this is a Type II supernova.

  17. Incidentally discovered adrenal tumors: a lesson from observation of 1,444 patients.

    Science.gov (United States)

    Kasperlik-Załuska, A A; Otto, M; Cichocki, A; Rosłonowska, E; Słowińska-Srzednicka, J; Jeske, W; Papierska, L; Zgliczyński, W

    2008-05-01

    This study was aimed at summarizing our experience in the management of 1,444 patients with incidentally found adrenal tumors observed at a single endocrinological centre. Hormonal determinations were performed in all patients at the beginning of the observation period to detect subclinical adrenal hyperfunction. The imaging phenotype on CT and MRI was analyzed for defining the malignant potential of the tumors. Based on the results of these examinations we diagnosed among our cohort probably benign masses in 87%, malignant tumors in 10% (adrenal carcinoma - 9%), and metastases in 3%. Subclinical hyperfunction was diagnosed in 8%; the most frequent was the pre-Cushing's syndrome. A subgroup of 480 patients (33%) was submitted to surgery because of oncological or endocrinological indications. The patients not qualified for surgery were carefully controlled by imaging and hormonal examinations. Malignancy is the most serious risk in the group of patients with incidentally discovered adrenal tumors.

  18. Systolic Tree Algorithms for Discovering High Utility Item sets from Transactional Database

    Directory of Open Access Journals (Sweden)

    B. Shibi

    2015-10-01

    Full Text Available Utility mining emerges as an important topic in data mining field. Here high utility itemsets mining refers to importance or profitability of an item to users. Efficient mining of high utility itemsets plays an important role in many real-life applications and is an important research issue in data mining area. Number of Algorithms utility pattern growth (UP-Growth and UP-Growth+( A data structure having tree like structure named utility pattern tree (UP-Tree is used for storing the information about high utility item set such that by using only double scanning of database, candidate itemsets can be efficiently generate. But that will lead to high requirement of space and time and so that performance will be less. So a new algorithm is proposed in this paper, for efficient discovering of high utility itemsets from transactional database.

  19. SDSS J115517.35+634622.0: A Newly Discovered Gravitationally Lensed Quasar

    CERN Document Server

    Pindor, B; Inada, N; Gregg, M D; Becker, R H; Brinkmann, J; Burles, S; Frieman, J A; Johnston, D E; Richards, G T; Schneider, D P; Scraton, R; Sekiguchi, M; Turner, E L; York, D G; Pindor, Bart; Eisenstein, Daniel J.; Inada, Naohisa; Gregg, Michael D.; Becker, Robert H.; Brinkmann, Jon; Burles, Scott; Frieman, Joshua A.; Johnston, David E.; Richards, Gordon T.; Schneider, Donald P.; Scraton, Ryan; Sekiguchi, Maki; Turner, Edwin L.; York, Donald G.

    2003-01-01

    We report the discovery of SDSSJ115517.35+634622.0, a previously unknown gravitationally lensed quasar. The lens system exhibits two images of a $z = 2.89$ quasar, with an image separation of $1{\\farcs}832 \\pm 0.007$ . Near-IR imaging of the system reveals the presence of the lensing galaxy between the two quasar images. Based on absorption features seen in the Sloan Digital Sky Survey (SDSS) spectrum, we determine a lens galaxy redshift of $z = 0.1756$. The lens is rather unusual in that one of the quasar images is only $0{\\farcs}22\\pm0{\\farcs}07$ ($\\sim 0.1 R_{\\rm eff}$) from the center of the lens galaxy and photometric modeling indicates that this image is significantly brighter than predicted by a SIS model. This system was discovered in the course of an ongoing search for strongly lensed quasars in the dataset from the SDSS.

  20. Timing and Interstellar Scattering of Thirty-five Distant Pulsars Discovered in the PALFA Survey

    CERN Document Server

    Nice, D J; Bogdanov, S; Cordes, J M; Farrington, D; Hessels, J W T; Kaspi, V M; Lyne, A G; Popa, L; Ransom, S M; Sanpa-arsa, S; Stappers, B W; Wang, Y; Allen, B; Bhat, N D R; Brazier, A; Camilo, F; Champion, D J; Chatterjee, S; Crawford, F; Deneva, J S; Desvignes, G; Freire, P C C; Jenet, F A; Knispel, B; Lazarus, P; Lee, K J; van Leeuwen, J; Lorimer, D R; Lynch, R; McLaughlin, M A; Scholz, P; Siemens, X; Stairs, I H; Stovall, K; Venkataraman, A; Zhu, W

    2013-01-01

    We have made extensive observations of 35 distant slow (non-recycled) pulsars discovered in the ongoing Arecibo PALFA pulsar survey. Timing observations of these pulsars over several years at Arecibo Observatory and Jodrell Bank Observatory have yielded high-precision positions and measurements of rotation properties. Despite being a relatively distant population, the properties of these pulsars mirror those of the previously known pulsar population. Many of the sources exhibit timing noise, and one underwent a small glitch. We have used multifrequency data to measure the interstellar scattering properties of these pulsars. We find scattering to be higher than predicted along some lines of sight, particularly in the Cygnus region. Lastly, we present XMM-Newton and Chandra observations of the youngest and most energetic of the pulsars, J1856+0245, which has previously been associated with the GeV-TeV pulsar wind nebula HESS J1857+026.

  1. A Hidden Population of Massive Stars with Circumstellar Shells Discovered with the Spitzer Space Telescope

    CERN Document Server

    Wachter, S; Van Dyk, S D; Hoard, D W; Kafka, S; Morris, P W

    2010-01-01

    We have discovered a large number of circular and elliptical shells at 24 microns around luminous central sources with the MIPS instrument on-board the Spitzer Space Telescope. Our archival follow-up effort has revealed 90% of these circumstellar shells to be previously unknown. The majority of the shells is only visible at 24 microns, but many of the central stars are detected at multiple wavelengths from the mid- to the near-IR regime. The general lack of optical counterparts, however, indicates that these sources represent a population of highly obscured objects. We obtained optical and near-IR spectroscopic observations of the central stars and find most of these objects to be massive stars. In particular, we identify a large population of sources that we argue represents a narrow evolutionary phase, closely related or identical to the LBV stage of massive stellar evolution.

  2. G306.3-0.9: A Newly Discovered Young Galactic Supernova Remnant

    Science.gov (United States)

    Reynolds, Mark T.; Loi, Syheh T.; Murphy, Tara; Miller, Jon M.; Maitra, Dipankar; Gueltekin, Kayhan; Gehrels, Neil; Kennea, Jamie A.; Siegel, Michael H.; Gelbord, Jonathan; Kuin, Paul; Moss, Vanessa; Reeves, Sarah; Robbins, William J.; Gaensler, B. M.; Reis, Rubens C.; Petre, Robert

    2013-01-01

    We present X-ray and radio observations of the new Galactic supernova remnant (SNR) G306.3-0.9, recently discovered by Swift. Chandra imaging reveals a complex morphology, dominated by a bright shock. The X-ray spectrum is broadly consistent with a young SNR in the Sedov phase, implying an age of 2500 yr for a distance of 8 kpc, plausibly identifying this as one of the 20 youngest Galactic SNRs. Australia Telescope Compact Array imaging reveals a prominent ridge of radio emission that correlates with the X-ray emission. We find a flux density of 160 mJy at 1 GHz, which is the lowest radio flux recorded for a Galactic SNR to date. The remnant is also detected at 24µm, indicating the presence of irradiated warm dust. The data reveal no compelling evidence for the presence of a compact stellar remnant.

  3. Strategy to discover diverse optimal molecules in the small molecule universe.

    Science.gov (United States)

    Rupakheti, Chetan; Virshup, Aaron; Yang, Weitao; Beratan, David N

    2015-03-23

    The small molecule universe (SMU) is defined as a set of over 10(60) synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework ( Virshup et al. J. Am. Chem. Soc. 2013 , 135 , 7296 - 7303 ) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 10(5) molecules.

  4. Newly Discovered Wolf-Rayet and Weak Emission-Line Central Stars of Planetary Nebulae

    CERN Document Server

    DePew, Kyle; Miszalski, Brent; De Marco, Orsola; Frew, David J; Acker, Agnes; Kovacevic, Anna V; Sharp, Rob G

    2011-01-01

    We present spectra of 32 previously unpublished confirmed and candidate Wolf-Rayet ([WR]) and weak emission-line (WELS) central stars of planetary nebulae (CSPNe). Eighteen stars have been discovered in the Macquarie/AAO/Strasbourg H-Alpha (MASH) PN survey sample, and we have also uncovered 14 confirmed and candidate [WR]s and WELS among the CSPNe of previously known PNe. Spectral classifications have been undertaken using both the Acker & Neiner and Crowther, De Marco & Barlow schemes. Twenty-two members in this sample are identified as probable [WR]s; the remaining 10 appear to be WELS. Observations undertaken as part of the MASH spectroscopic survey have now increased the number of known [WR]s by ~30 per cent. This will permit a better analysis of [WR] subclass distribution, metallicity effects, and evolutionary sequences in these uncommon objects.

  5. An updated survey of globular clusters in M31. II Newly discovered bright and remote clusters

    CERN Document Server

    Galleti, S; Federici, L; Buzzoni, A; Pecci, F Fusi

    2007-01-01

    We present the first results of a large spectroscopic survey of candidate globular clusters located in the extreme outskirts of the nearby M31 galaxy. We obtained low resolution spectra of 48 targets selected from the XSC of 2MASS, as in Galleti et al. (2005). The observed candidates have been robustly classified according to their radial velocity and by verifying their extended/point-source nature from ground-based optical images. Among the 48 observed candidates clusters we found 5 genuine remote globular clusters. One of them has been already identified independently by Mackey et al. (2007), their GC1; the other four are completely new discoveries: B516, B517, B518, B519. The newly discovered clusters lie at projected distance 40 kpc 40 kpc. At odds with the Milky Way, M31 appears to have a significant population of very bright globular clusters in its extreme outskirts.

  6. G306.3-0.9: A NEWLY DISCOVERED YOUNG GALACTIC SUPERNOVA REMNANT

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Mark T.; Miller, Jon M.; Maitra, Dipankar; Gueltekin, Kayhan; Reis, Rubens C. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Loi, Shyeh T.; Murphy, Tara; Moss, Vanessa; Reeves, Sarah; Robbins, William J.; Gaensler, B. M. [Sydney Institute for Astronomy (SIfA), School of Physics, The University of Sydney, NSW 2006 (Australia); Gehrels, Neil; Petre, Robert [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Kennea, Jamie A.; Siegel, Michael H.; Gelbord, Jonathan [Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802 (United States); Kuin, Paul, E-mail: markrey@umich.edu [Mullard Space Science Laboratory, University College London, Holmbury St Mary, Dorking, Surrey RH5 6NT (United Kingdom)

    2013-04-01

    We present X-ray and radio observations of the new Galactic supernova remnant (SNR) G306.3-0.9, recently discovered by Swift. Chandra imaging reveals a complex morphology, dominated by a bright shock. The X-ray spectrum is broadly consistent with a young SNR in the Sedov phase, implying an age of 2500 yr for a distance of 8 kpc, plausibly identifying this as one of the 20 youngest Galactic SNRs. Australia Telescope Compact Array imaging reveals a prominent ridge of radio emission that correlates with the X-ray emission. We find a flux density of {approx}160 mJy at 1 GHz, which is the lowest radio flux recorded for a Galactic SNR to date. The remnant is also detected at 24 {mu}m, indicating the presence of irradiated warm dust. The data reveal no compelling evidence for the presence of a compact stellar remnant.

  7. G306.3-0.9: A newly discovered young galactic supernova remnant

    CERN Document Server

    Reynolds, Mark; Murphy, Tara; Miller, Jon; Maitra, Dipankar; Gultekin, Kayhan; Gehrels, Neil; Kennea, Jamie; Siegel, Michael; Gelbord, Jonathan; Kuin, Paul; Moss, Vanessa; Reeves, Sarah; Robbins, William; Gaensler, Bryan; Reis, Rubens; Petre, Robert

    2013-01-01

    We present X-ray and radio observations of the new Galactic supernova remnant (SNR) G306.3-0.9, recently discovered by Swift. Chandra imaging reveals a complex morphology, dominated by a bright shock. The X-ray spectrum is broadly consistent with a young SNR in the Sedov phase, implying an age of 2500 yr for a distance of 8 kpc, plausibly identifying this as one of the 20 youngest Galactic SNRs. Australia Telescope Compact Array (ATCA) imaging reveals a prominent ridge of radio emission that correlates with the X-ray emission. We find a flux density of ~ 160 mJy at 1 GHz, which is the lowest radio flux recorded for a Galactic SNR to date. The remnant is also detected at 24microns, indicating the presence of irradiated warm dust. The data reveal no compelling evidence for the presence of a compact stellar remnant.

  8. Restoration and Preservation of Engraved Limestone Blocks Discovered in Abu Mousa Excavation, Suez - Egypt

    Directory of Open Access Journals (Sweden)

    Nabil A. Abd El-Tawab BADER

    2013-03-01

    Full Text Available A lot of engraved limestone blocks were discovered at Awlad Abu Musa (east of Suez, Egypt in 1995/2007 by Supreme Council of Antiquities. The stone blocks were seriously affected by archaeological environments during burial environment in agriculture land. They were covered with thick clay layer with soil particles that disfigured them and hid their inscriptions. Prior to the conservation intervention, the materials were characterized by X-ray diffraction, optical microscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Chemical analyses of ground water and microbiological study. After the material characterization, the conservation and restoration of the stone blocks were carried out including cleaning, consolidation, reduction of salts, Re-jointing, restoration and completion of lost parts. After that the blocks were exhibited in Suez museum.

  9. sp3-hybridized framework structure of group-14 elements discovered by genetic algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Manh Cuong [Ames Laboratory; Zhao, Xin [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory

    2014-05-01

    Group-14 elements, including C, Si, Ge, and Sn, can form various stable and metastable structures. Finding new metastable structures of group-14 elements with desirable physical properties for new technological applications has attracted a lot of interest. Using a genetic algorithm, we discovered a new low-energy metastable distorted sp3-hybridized framework structure of the group-14 elements. It has P42/mnm symmetry with 12 atoms per unit cell. The void volume of this structure is as large as 139.7Å3 for Si P42/mnm, and it can be used for gas or metal-atom encapsulation. Band-structure calculations show that P42/mnm structures of Si and Ge are semiconducting with energy band gaps close to the optimal values for optoelectronic or photovoltaic applications. With metal-atom encapsulation, the P42/mnm structure would also be a candidate for rattling-mediated superconducting or used as thermoelectric materials.

  10. Discovering Global Patterns in Linguistic Networks through Spectral Analysis: A Case Study of the Consonant Inventories

    CERN Document Server

    Mukherjee, Animesh; Kannan, Ravi

    2009-01-01

    Recent research has shown that language and the socio-cognitive phenomena associated with it can be aptly modeled and visualized through networks of linguistic entities. However, most of the existing works on linguistic networks focus only on the local properties of the networks. This study is an attempt to analyze the structure of languages via a purely structural technique, namely spectral analysis, which is ideally suited for discovering the global correlations in a network. Application of this technique to PhoNet, the co-occurrence network of consonants, not only reveals several natural linguistic principles governing the structure of the consonant inventories, but is also able to quantify their relative importance. We believe that this powerful technique can be successfully applied, in general, to study the structure of natural languages.

  11. TIMING AND INTERSTELLAR SCATTERING OF 35 DISTANT PULSARS DISCOVERED IN THE PALFA SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Nice, D. J. [Department of Physics, Lafayette College, Easton, PA 18042 (United States); Altiere, E.; Farrington, D.; Popa, L.; Wang, Y. [Department of Physics, Bryn Mawr College, Bryn Mawr, PA 19010 (United States); Bogdanov, S.; Camilo, F. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Cordes, J. M.; Brazier, A.; Chatterjee, S. [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States); Hessels, J. W. T. [ASTRON, The Netherlands Institute for Radio Astronomy, Postbus 2, 7990-AA Dwingeloo (Netherlands); Kaspi, V. M. [Department of Physics, McGill University, Montreal, QC H3A 2T8 (Canada); Lyne, A. G.; Stappers, B. W. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL (United Kingdom); Ransom, S. M. [NRAO, Charlottesville, VA 22903 (United States); Sanpa-arsa, S. [Department of Astronomy, University of Virginia, Charlottesville, VA 22903 (United States); Allen, B. [Max-Planck-Institut fuer Gravitationsphysik, D-30167 Hannover (Germany); Bhat, N. D. R. [Center for Astrophysics and Supercomputing, Swinburne University, Hawthorn, Victoria 3122 (Australia); Champion, D. J. [Max-Planck-Institut fuer Radioastronomie, D-53121 Bonn (Germany); Crawford, F. [Department of Physics and Astronomy, Franklin and Marshall College, Lancaster, PA 17604-3003 (United States); and others

    2013-07-20

    We have made extensive observations of 35 distant slow (non-recycled) pulsars discovered in the ongoing Arecibo PALFA pulsar survey. Timing observations of these pulsars over several years at Arecibo Observatory and Jodrell Bank Observatory have yielded high-precision positions and measurements of rotation properties. Despite being a relatively distant population, these pulsars have properties that mirror those of the previously known pulsar population. Many of the sources exhibit timing noise, and one underwent a small glitch. We have used multifrequency data to measure the interstellar scattering properties of these pulsars. We find scattering to be higher than predicted along some lines of sight, particularly in the Cygnus region. Finally, we present XMM-Newton and Chandra observations of the youngest and most energetic of the pulsars, J1856+0245, which has previously been associated with the GeV-TeV pulsar wind nebula HESS J1857+026.

  12. Langley Mobile Ozone Lidar (LMOL) results from the Denver, CO DISCOVER-AQ campaign

    Science.gov (United States)

    De Young, Russell; Carrion, William; Pliutau, Denis; Ganoe, Rene

    2015-10-01

    The Langley Mobile Ozone Lidar (LMOL) is a compact mobile differential absorption lidar (DIAL) system that was developed at NASA Langley Research Center, Hampton, VA, USA to provide ozone, aerosol and cloud atmospheric measurements in a mobile trailer for ground-based atmospheric air quality campaigns. This lidar is part of the Tropospheric Ozone Lidar Network (TOLNet) currently made up of six other ozone lidars across the U.S and Canada. This lidar has been deployed to Denver, CO July 15-August 15, 2014 for the DISCOVER-AQ air quality campaign. Ozone and aerosol profiles were taken showing the influence of emissions from the Denver region. Results of ozone concentration, aerosol scattering ratio, boundary layer height and clouds will be presented with emphasis on regional air quality.

  13. Local NASA Scientists Discover New Species of Organism in Mars-Like Environment

    Science.gov (United States)

    2003-01-01

    Microbiologist Dr. Elena V. Pikuta, and Astrobiologist Richard Hoover culture extremophiles, microorganisms that can live in extreme environments, in the astrobiology laboratory at the National Space Science and Technology Center (NSSTC) in Huntsville, Alabama. The scientists recently discovered a new species of extremophiles, Spirochaeta Americana. The species was found in Northern California's Mono Lake, an alkaline, briny oxygen-limited lake in a closed volcanic crater that Hoover believes may offer new clues to help identify sites to research for potential life on Mars. Hoover is an astrobiologist at NASA's Marshall Space Flight Center (MSFC), and Pikuta is a microbiologist with the Center for Space Plasma and Aeronomy Research Laboratory at the University of Alabama in Huntsville. The NSSTC is a partnership with MSFC, Alabama universities, industry, research institutes, and federal agencies.

  14. Technical photography for mural paintings: the newly discovered frescoes in Aci Sant’Antonio (Sicily, Italy

    Directory of Open Access Journals (Sweden)

    A. Cosentino

    2015-02-01

    Full Text Available A cycle of 18th century frescoes, depicting the last days of Christ on earth, were recently discovered in Aci Sant’Antonio (Sicily, Italy. The paintings survive along the corners of an originally square chapel that was altered in the early 20th century, acquiring the current octagonal plan. This paper presents the results of the technical photography documentation of these wall paintings and illustrates the methodological challenges that were posed during their examination. Raking light photography was used to reveal the paintings’ state of conservation, details of the plaster work and painting techniques. Ultraviolet fluorescence and infrared false color photography were also performed to evaluate areas of interest for further analytical and diagnostic studies. The first striking feature is the lack of giornate. Only pontate are clearly seen in all the scenes thus indicating that in the larger paint areas, a mixed of fresco and secco technique would have been used.

  15. Discovering, Indexing and Interlinking Information Resources [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Fabrizio Celli

    2015-11-01

    Full Text Available The social media revolution is having a dramatic effect on the world of scientific publication. Scientists now publish their research interests, theories and outcomes across numerous channels, including personal blogs and other thematic web spaces where ideas, activities and partial results are discussed. Accordingly, information systems that facilitate access to scientific literature must learn to cope with this valuable and varied data, evolving to make this research easily discoverable and available to end users. In this paper we describe the incremental process of discovering web resources in the domain of agricultural science and technology. Making use of Linked Open Data methodologies, we interlink a wide array of custom-crawled resources with the AGRIS bibliographic database in order to enrich the user experience of the AGRIS website. We also discuss the SemaGrow Stack, a query federation and data integration infrastructure used to estimate the semantic distance between crawled web resources and AGRIS.

  16. Resolving the wave vector in negative refractive index media.

    Science.gov (United States)

    Ramakrishna, S Anantha; Martin, Olivier J F

    2005-10-01

    We address the general issue of resolving the wave vector in complex electromagnetic media including negative refractive media. This requires us to make a physical choice of the sign of a square root imposed merely by conditions of causality. By considering the analytic behavior of the wave vector in the complex plane, it is shown that there are a total of eight physically distinct cases in the four quadrants of two Riemann sheets.

  17. Time-resolved THz spectroscopy in a parallel plate waveguide

    DEFF Research Database (Denmark)

    Cooke, David; Jepsen, Peter Uhd

    2009-01-01

    We demonstrate time-resolved terahertz spectroscopy inside a novel parallel plate waveguide where one of the metallic plates is replaced by a transparent conducting oxide. Considerable improvements to the waveguide loss coefficient are shown, with a power absorption coefficient of 4cm-1 at 0.5 THz....... The time resolution of the technique is shown to be limited by the spatial excitation profile, which for sharply focused beams can approach ~1 ps time scales....

  18. Improving Earthquake Stress Drop Measurements - What can we Really Resolve?

    Science.gov (United States)

    Abercrombie, R. E.; Bannister, S. C.; Fry, B.; Ruhl, C. J.; Kozlowska, M.

    2015-12-01

    Earthquake stress drop is fundamental to understanding the physics of the rupture process. Although it is superficially simple to calculate an estimate of stress drop from the corner frequency of the radiated spectrum, it is much harder to be certain that measurements are reliable and accurate. The same is true of other measurements of stress drop and radiated energy. The large number of studies of earthquake stress drop, the high variability in results (~0.1-100 MPa), the large uncertainties, and the ongoing scaling controversy are evidence for this. We investigate the resolution and uncertainties of stress drops calculated using an empirical Green's function (EGF) approach. Earthquakes in 3 sequences at Parkfield, California are recorded by multiple borehole stations and have abundant smaller earthquakes to use as EGFs (Abercrombie, 2014). The earthquakes in the largest magnitude cluster (M~2.1) exhibit clear temporal variation of stress drop. Independent studies obtained a similar pattern implying that it is resolvable for these well-recorded, simple sources. The borehole data reveal a similar temporal pattern for another sequence, not resolvable in an earlier study using surface recordings. The earthquakes in the third sequence have complex sources; corner frequency measurements for this sequence are highly variable and poorly resolved. We use the earthquakes in the first cluster to quantify the uncertainties likely to arise in less optimal settings. The limited signal bandwidth and the quality of the EGF assumption are major sources of error. Averaging across multiple stations improves the resolution, as does using multiple good EGFs (Abercrombie, 2015). We adapt the approach to apply to larger data sets. We focus on New Zealand, with the aim of resolving stress drop variability in a variety of tectonic settings. We investigate stacking over stations and multiple EGFs, and compare earthquakes (M~3-6) from both the overlying and the subducting plates.

  19. Studying the Stereochemistry of Naproxen Using Rotationally Resolved Electronic Spectroscopy.

    Science.gov (United States)

    Young, Justin W.; Alvarez-Valtierra, Leonardo; Pratt, David W.

    2009-06-01

    Many biochemical processes are stereospecific. An example is the physiological response to a drug that depends on its enantiomeric form. Naproxen is a drug which shows this stereo-specific physiological response. To better understand the stereo specificity of chiral substances, we observed the S_1←S_0 transitions of R- and S-naproxen in the gas phase using rotationally resolved electronic spectroscopy. The results will be discussed.

  20. Introductory lecture: Time-resolved chemistry at atomic resolution.

    Science.gov (United States)

    Coppens, Philip; Novozhilova, Irina V

    2003-01-01

    Though time-resolved studies are still at an early stage, the field is rapidly being developed and applied to an increasingly broad spectrum of problems with timescales varying from seconds or more down to femtoseconds. In this overview a number of different techniques are discussed, with emphasis on chemical applications in which information is obtained at the atomic level. The need to correlate with theory, both for calibration of theoretical methods and to obtain related information not accessible experimentally, is stressed.

  1. Theory of time-resolved inelastic x-ray diffraction

    DEFF Research Database (Denmark)

    Lorenz, Ulf; Møller, Klaus Braagaard; Henriksen, Niels Engholm

    2010-01-01

    Starting from a general theory of time-resolved x-ray scattering, we derive a convenient expression for the diffraction signal based on a careful analysis of the relevant inelastic scattering processes. We demonstrate that the resulting inelastic limit applies to a wider variety of experimental...... conditions than similar, previously derived formulas, and it directly allows the application of selection rules when interpreting diffraction signals. Furthermore, we present a simple extension to systems simultaneously illuminated by x rays and a laser beam....

  2. Existence of Almost Resolvable Directed 7-Cycle Systems

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Let ARDkCS(v) denote an almost resolvable directed k-cycle system of order v. It is clear that a necessary condition for the existence of an ARDkCS(v) is v≡1(mod k). For k= 3,4,5 and 6, the existence of an ARDkCS(v) had been completely solved. This paper shows that there exists an ARD7CS(v) if and only if v≡1(mod 7) and v≥8.

  3. Time-resolved imaging of latent fingerprints with nanosecond resolution

    Science.gov (United States)

    Seah, L. K.; Dinish, U. S.; Ong, S. K.; Chao, Z. X.; Murukeshan, V. M.

    2004-07-01

    Imaging of latent fingerprints using time-resolved (TR) method offers a broader platform to eliminate the unwanted background emission. In this paper, a novel TR imaging technique is demonstrated and implemented, which facilitates the detection of latent fingerprints with nanosecond resolution. Simulated experiments were carried out with two overlapping fingerprints treated with two fluorescent powders having different lifetimes in nanosecond range. The dependence of the fluorescence emission intensity in nanosecond resolution of TR imaging is also revealed.

  4. Refinement of thermal imager minimum resolvable temperature difference calculating method

    Science.gov (United States)

    Kolobrodov, V. G.; Mykytenko, V. I.

    2015-11-01

    Calculating methods, which accurately predict minimum resolvable temperature difference (MRTD), are of significant interest for many years. The article deals with improvement the accuracy of determining the thermal imaging system MRTD by elaboration the visual perception model. We suggest MRTD calculating algorithm, which is based on a reliable approximation of the human visual system modulation transfer function (MTF) proposed by N. Nill. There was obtained a new expression for the bandwidth evaluation, which is independent of angular size of the Foucault bar target.

  5. ESTIMATION OF THERMAL IMAGER MINIMUM RESOLVABLE TEMPERATURE DIFFERENCE

    Directory of Open Access Journals (Sweden)

    Ahmed M.L. Al-Mzirawi

    2015-01-01

    Full Text Available The paper is devoted to improving the accuracy of determining the minimum resolvable temperature difference (MRTD of thermal imagers by means of more sophisticated models of thermal images visual perception. An MRTD calculating algorithm, which is based on a more reliable approximation of the visual system modulation transfer function by Schultz, is considered. New expression for the bandwidth of Schultz's approximation, which does not depend on the angular size of the Foucault pattern bar, was obtained.

  6. Depth-resolved measurements with elliptically polarized reflectance spectroscopy.

    Science.gov (United States)

    Bailey, Maria J; Sokolov, Konstantin

    2016-07-01

    The ability of elliptical polarized reflectance spectroscopy (EPRS) to detect spectroscopic alterations in tissue mimicking phantoms and in biological tissue in situ is demonstrated. It is shown that there is a linear relationship between light penetration depth and ellipticity. This dependence is used to demonstrate the feasibility of a depth-resolved spectroscopic imaging using EPRS. The advantages and drawbacks of EPRS in evaluation of biological tissue are analyzed and discussed.

  7. Time Resolved Broadband Terahertz Relaxation Dynamics of Electron in Water

    DEFF Research Database (Denmark)

    Wang, Tianwu; Iwaszczuk, Krzysztof; Cooke, David G.;

    We investigated the transient response of the solvated electron in water ejected by photodetachment from potassium ferrocyanide using time resolved terahertz spectroscopy (TSTS). Ultrabroadband THz transients are generated and detected by a two-color femtosecond-induced air plasma and air biased...... coherent detection, respectively. We find that the measured frequency dependent conductivity can be well described by a Drude-Smith model, supplemented by a Lorentz model oscillating near 5 THz....

  8. Resolving Conflicts between Agriculture and the Natural Environment.

    Directory of Open Access Journals (Sweden)

    Andrew J Tanentzap

    Full Text Available Agriculture dominates the planet. Yet it has many environmental costs that are unsustainable, especially as global food demand rises. Here, we evaluate ways in which different parts of the world are succeeding in their attempts to resolve conflict between agriculture and wild nature. We envision that coordinated global action in conserving land most sensitive to agricultural activities and policies that internalise the environmental costs of agriculture are needed to deliver a more sustainable future.

  9. Time-resolved laser-induced breakdown spectroscopy of aluminum

    Institute of Scientific and Technical Information of China (English)

    LIU Xian-yun; ZHANG Wei-jun; WANG Zhen-ya; HAO Li-qing; HUANG Ming-qiang; ZHAO Wen-wu; LONG Bo; Zhao Wei

    2008-01-01

    We develop a system to measure the elemental composition of unprepared samples using laser-induced breakdown spectroscopy (LIBS) in our laboratory, which can be used for the determination of elements in solids, liquids and aerosols. A description of the instrumentation, including laser, sample chamber and detection, is followed by a brief discussion. The time-resolved LIBS of aluminum at atmospheric pressure is presented. At the end, the possibilities and later uses of this technique are briefly discussed.

  10. Time-resolved CT angiography in aortic dissection

    Energy Technology Data Exchange (ETDEWEB)

    Meinel, Felix G., E-mail: felix.meinel@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Nikolaou, Konstantin, E-mail: konstantin.nikolaou@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Weidenhagen, Rolf, E-mail: rolf.weidenhagen@med.uni-muenchen.de [Department of Surgery, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Hellbach, Katharina, E-mail: katharina.hellbach@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Helck, Andreas, E-mail: andreas.helck@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Bamberg, Fabian, E-mail: fabian.bamberg@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Reiser, Maximilian F., E-mail: maximilian.reiser@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany); Sommer, Wieland H., E-mail: wieland.sommer@med.uni-muenchen.de [Department of Clinical Radiology, Ludwig Maximilians-University, Marchioninistr. 15, 81377 Munich (Germany)

    2012-11-15

    Objectives: We performed this study to assess feasibility and additional diagnostic value of time-resolved CT angiography of the entire aorta in patients with aortic dissection. Materials and methods: 14 consecutive patients with known or suspected aortic dissection (aged 60 {+-} 9 years) referred for aortic CT angiography were scanned on a dual-source CT scanner (Somatom Definition Flash; Siemens, Forchheim, Germany) using a shuttle mode for multiphasic image acquisition (range 48 cm, time resolution 6 s, 6 phases, 100 kV, 110 mAs/rot). Effective radiation doses were calculated from recorded dose length products. For all phases, CT densities were measured in the aortic lumen and renal parenchyma. From the multiphasic data, 3 phases corresponding to a triphasic standard CT protocol, served as a reference and were compared against findings from the time-resolved datasets. Results: Mean effective radiation dose was 27.7 {+-} 3.5 mSv. CT density of the true lumen peaked at 355 {+-} 53 HU. Compared to the simulated triphasic protocol, time-resolved CT angiography added diagnostic information regarding a number of important findings: the enhancement delay between true and false lumen (n = 14); the degree of membrane oscillation (n = 14); the perfusion delay in arteries originating from the false lumen (n = 9). Other additional information included true lumen collapse (n = 4), quantitative assessment of renal perfusion asymmetry (n = 2), and dynamic occlusion of aortic branches (n = 2). In 3/14 patients (21%), these additional findings of the multiphasic protocol altered patient management. Conclusions: Multiphasic, time-resolved CT angiography covering the entire aorta is feasible at a reasonable effective radiation dose and adds significant diagnostic information with therapeutic consequences in patients with aortic dissection.

  11. Mining Low-Variance Biclusters to Discover Coregulation Modules in Sequencing Datasets

    Directory of Open Access Journals (Sweden)

    Zhen Hu

    2012-01-01

    Full Text Available High-throughput sequencing (CHIP-Seq data exhibit binding events with possible binding locations and their strengths, followed by interpretation of the locations of peaks. Recent methods tend to summarize all CHIP-Seq peaks detected within a limited up and down region of each gene into one real-valued score in order to quantify the probability of regulation in a region. Applying subspace clustering techniques on these scores can help discover important knowledge such as the potential co-regulation or co-factor mechanisms. The ideal biclusters generated would contain subsets of genes and transcription factors (TF such that the cell-values in biclusters are distributed around a mean value with very low variance. Such biclusters would indicate TF sets regulating gene sets with very similar probability values. However, most existing biclustering algorithms neither enforce low variance as the desired property of a bicluster, nor use variance as a guiding metric while searching for the desirable biclusters. In this paper we present an algorithm that searches a space of all overlapping biclusters organized in a lattice, and uses an upper bound on variance values of biclusters as the guiding metric. We show the algorithm to be an efficient and effective method for discovering the possibly overlapping biclusters under pre-defined variance bounds. We present in this paper our algorithm, its results with synthetic, CHIP-Seq and motif datasets, and compare them with the results obtained by other algorithms to demonstrate the power and effectiveness of our algorithm.

  12. Searching for Dark Matter Annihilation in Recently Discovered Milky Way Satellites with Fermi-Lat

    Science.gov (United States)

    Albert, A.; Anderson, B.; Bechtol, K.; Drlica-Wagner, A.; Meyer, M.; Sánchez-Conde, M.; Strigari, L.; Wood, M.; Abbott, T. M. C.; Abdalla, F. B.; Benoit-Lévy, A.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Burke, D. L.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Crocce, M.; Cunha, C. E.; D’Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Fausti Neto, A.; Finley, D. A.; Flaugher, B.; Fosalba, P.; Frieman, J.; Gerdes, D. W.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Honscheid, K.; James, D. J.; Kent, S.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Maia, M. A. G.; March, M.; Marshall, J. L.; Martini, P.; Miller, C. J.; Miquel, R.; Neilsen, E.; Nord, B.; Ogando, R.; Plazas, A. A.; Reil, K.; Romer, A. K.; Rykoff, E. S.; Sanchez, E.; Santiago, B.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Vikram, V.; Walker, A. R.; Wechsler, R. H.; Fermi-LAT Collaboration; DES Collaboration

    2017-01-01

    We search for excess γ-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (LAT). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted γ-ray flux due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. LAT data coincident with four of the newly discovered targets show a slight preference (each ∼ 2σ local) for γ-ray emission in excess of the background. However, the ensemble of derived γ-ray flux upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance < 1σ ). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ∼2 for large DM masses ({m}{DM,b\\bar{b}}≳ 1 {TeV} and {m}{DM,{τ }+{τ }-}≳ 70 {GeV}) and weakening by a factor of ∼1.5 at lower masses relative to previously observed limits.

  13. 寻找序列的变化内容%Discover difference between sequences

    Institute of Scientific and Technical Information of China (English)

    张晓敏; 陈昊; 明仲

    2011-01-01

    To discover the difference Z between two sequences, named X and Y,it changes X to Y through the difference information Z.If X and Y are two different versions of the same file, Z is much smaller than X.Therefore, it is a good idea to store or transfer Z instead of Xto solve that problem,X and Y can be both separated into several parts and the corresponding parts can be treated as sub-problems.In the same time the sub-sequences that are the same can be discovered.The algorithm's implementation takes 0((n+m)log(min(n,m))) time and O(n+m) space,in which n and m are the length of X and Y, respectively.%寻找两个序列X、Y的差异内容,产生y相对X的差异信息Z,使得X能够根据Z变化为y.如果X、Y是同一种文件的不同版本,Z往往比y小得多,这样存储或传送Z将比直接存储或传送y更节约资源.提出一种基于序列结构因素的启发式算法,对两个序列进行划分,再进行相同内容的匹配.算法时间复杂度为O( (n+m)log(min(n,m))),空间复杂度为O(n+m),其中n、m分别为X,Y的长度.在实际应用中该算法的执行速度是接近线性的.

  14. Scout: short-arc orbit analysis and hazard assessment for newly discovered asteroids

    Science.gov (United States)

    Farnocchia, Davide; Chesley, Steven R.; Micheli, Marco

    2016-05-01

    It typically takes a few days for a newly discovered asteroid to be officially recognized as a real object. This time is needed to collect additional data and make sure the observations belong to an actual asteroid rather than being an artifact or corresponding to an artificial object. However, asteroids could experience an Earth close approach or even an impact only a few days or less after the discovery observations, as in the cases of 2008 TC3 and 2014 AA, i.e., the only two asteroids discovered before an Earth impact. In such cases, a rapid identification of the close approach or impact dramatically improves the chances of securing the asteroid's trajectory with additional observations prior to impact. Scout is an automated system that provides an orbital and hazard assessment for new potential asteroid discoveries within minutes after the observations are available. Since the time interval covered by the observations is generally short, perhaps only a few hours or even less, there are severe degeneracies in the orbit estimation process. To overcome these degeneracies Scout relies on systematic ranging, a technique that scans the poorly constrained space of topocentric range and range rate, while the plane-of-sky position and motion are directly tied to the recorded observations. This scan allows us to identify the possible orbits and the regions corresponding to collision solutions, as well as potential impact times and locations. From the probability distribution of the observation errors, Scout derives a probability distribution in the orbital space and in turn estimates several metrics of interest, e.g., probability of an Earth impact, of a close approach to Earth, and of being a mission-accessible target.

  15. High throughput techniques for discovering new glycine receptor modulators and their binding sites

    Directory of Open Access Journals (Sweden)

    Daniel F Gilbert

    2009-10-01

    Full Text Available The inhibitory glycine receptor (GlyR is a member of the Cys-loop receptor family that mediates inhibitory neurotransmission in the central nervous system. These receptors are emerging as potential drug targets for inflammatory pain, immunomodulation, spasticity and epilepsy. Antagonists that specifically inhibit particular GlyR isoforms are also required as pharmacological probes for elucidating the roles of particular GlyR isoforms in health and disease. Although a substantial number of both positive and negative GlyR modulators have been identified, very few of these are specific for the GlyR over other receptor types. Thus, the potential of known compounds as either therapeutic leads or pharmacological probes is limited. It is therefore surprising that there have been few published studies describing attempts to discover novel GlyR isoform-specific compounds. The first aim of this review is to consider various methods for efficiently screening compounds against these receptors. We conclude that an anion sensitive yellow fluorescent protein is optimal for primary screening and that automated electrophysiology of cells stably expressing GlyRs is useful for confirming hits and quantitating the actions of identified compounds. The second aim of this review is to demonstrate how these techniques are used in our laboratory for the purpose of both discovering novel GlyR-active compounds and characterizing their binding sites. We also describe a reliable, cost effective method for transfecting HEK293 cells in single wells of a 384 well plate using nanogram quantities of cDNA.

  16. Is it possible to discover a dark matter particle with an accelerator?

    Science.gov (United States)

    Bednyakov, V. A.

    2016-09-01

    The paper contains description of the main properties of the galactic dark matter (DM) particles, available approaches for detection of DM, main features of direct DM detection, ways to estimate prospects for the DM detection, the first collider search for a DM candidate within an Effective Field Theory, complete review of ATLAS results of the DM candidate search with LHC RUN I, and less complete review of "exotic" dark particle searches with other accelerators and not only. From these considerations it follows that one is unable to prove, especially model-independently, a discovery of a DM particle with an accelerator, or collider. One can only obtain evidence on existence of a weakly interacting neutral particle, which could be, or could not be the DM candidate. The current LHC DM search program uses only the missing transverse energy signature. Non-observation of any excess above Standard Model expectations forces the LHC experiments to enter into the same fighting for the best exclusion curve, in which (almost) all direct and indirect DM search experiments permanently take place. But this fighting has very little (almost nothing) to do with a real possibility of discovering a DM particle. The true DM particles possess an exclusive galactic signature—annual modulation of a signal, which is accessible today only for direct DM detection experiments. There is no way for it with a collider, or accelerator. Therefore to prove the DM nature of a collider-discovered candidate one must find the candidate in a direct DM experiment and demonstrate the galactic signature for the candidate. Furthermore, being observed, the DM particle must be implemented into a modern theoretical framework. The best candidate is the supersymmetry, which looks today inevitable for coherent interpretation of all available DM data.

  17. Resolving Isomeric Glycopeptide Glycoforms with Hydrophilic Interaction Chromatography (HILIC).

    Science.gov (United States)

    Huang, Yining; Nie, Yongxin; Boyes, Barry; Orlando, Ron

    2016-09-01

    The ability to resolve glycans while attached to tryptic peptides would greatly facilitate glycoproteomics, as this would enable site-specific glycan characterization. Peptide/glycopeptide separations are typically performed using reversed-phase liquid chromatography (RPLC), where retention is driven by hydrophobic interaction. As the hydrophilic glycans do not interact significantly with the RPLC stationary phase, it is difficult to resolve glycopeptides that differ only in their glycan structure, even when these differences are large. Alternatively, glycans interact extensively with the stationary phases used in hydrophilic interaction chromatography (HILIC), and consequently, differences in glycan structure have profound chromatographic shifts in this chromatographic mode. Here, we evaluate HILIC for the separation of isomeric glycopeptide mixtures that have the same peptide backbone but isomeric glycans. Hydrophilic functional groups on both the peptide and the glycan interact with the HILIC stationary phase, and thus, changes to either of these moieties can alter the chromatographic behavior of a glycopeptide. The interactive processes permit glycopeptides to be resolved from each other based on differences in their amino acid sequences and/or their attached glycans. The separations of glycans in HILIC are sufficient to permit resolution of isomeric N-glycan structures, such as sialylated N-glycan isomers differing in α2-3 and α2-6 linkages, while these glycans remain attached to peptides.

  18. Angle-resolved effective potentials for disk-shaped molecules

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, Thomas, E-mail: thomas.heinemann@tu-berlin.de; Klapp, Sabine H. L., E-mail: klapp@physik.tu-berlin.de [Institut für Theoretische Physik, Technische Universität Berlin, Hardenbergstr. 36, 10623 Berlin (Germany); Palczynski, Karol, E-mail: karol.palczynski@helmholtz-berlin.de; Dzubiella, Joachim, E-mail: joachim.dzubiella@helmholtz-berlin.de [Institut für Physik, Humboldt Universität zu Berlin, Newtonstraße 15, 12489 Berlin (Germany); Helmholtz Zentrum Berlin (HZB), Institute of Soft Matter and Functional Materials, Hahn-Meitner Platz 1, 14109 Berlin (Germany)

    2014-12-07

    We present an approach for calculating coarse-grained angle-resolved effective pair potentials for uniaxial molecules. For integrating out the intramolecular degrees of freedom we apply umbrella sampling and steered dynamics techniques in atomistically-resolved molecular dynamics (MD) computer simulations. Throughout this study we focus on disk-like molecules such as coronene. To develop the methods we focus on integrating out the van der Waals and intramolecular interactions, while electrostatic charge contributions are neglected. The resulting coarse-grained pair potential reveals a strong temperature and angle dependence. In the next step we fit the numerical data with various Gay-Berne-like potentials to be used in more efficient simulations on larger scales. The quality of the resulting coarse-grained results is evaluated by comparing their pair and many-body structure as well as some thermodynamic quantities self-consistently to the outcome of atomistic MD simulations of many-particle systems. We find that angle-resolved potentials are essential not only to accurately describe crystal structures but also for fluid systems where simple isotropic potentials start to fail already for low to moderate packing fractions. Further, in describing these states it is crucial to take into account the pronounced temperature dependence arising in selected pair configurations due to bending fluctuations.

  19. Angle-resolved effective potentials for disk-shaped molecules.

    Science.gov (United States)

    Heinemann, Thomas; Palczynski, Karol; Dzubiella, Joachim; Klapp, Sabine H L

    2014-12-07

    We present an approach for calculating coarse-grained angle-resolved effective pair potentials for uniaxial molecules. For integrating out the intramolecular degrees of freedom we apply umbrella sampling and steered dynamics techniques in atomistically-resolved molecular dynamics (MD) computer simulations. Throughout this study we focus on disk-like molecules such as coronene. To develop the methods we focus on integrating out the van der Waals and intramolecular interactions, while electrostatic charge contributions are neglected. The resulting coarse-grained pair potential reveals a strong temperature and angle dependence. In the next step we fit the numerical data with various Gay-Berne-like potentials to be used in more efficient simulations on larger scales. The quality of the resulting coarse-grained results is evaluated by comparing their pair and many-body structure as well as some thermodynamic quantities self-consistently to the outcome of atomistic MD simulations of many-particle systems. We find that angle-resolved potentials are essential not only to accurately describe crystal structures but also for fluid systems where simple isotropic potentials start to fail already for low to moderate packing fractions. Further, in describing these states it is crucial to take into account the pronounced temperature dependence arising in selected pair configurations due to bending fluctuations.

  20. Fixed Points of Averages of Resolvents: Geometry and Algorithms

    CERN Document Server

    Bauschke, Heinz H; Wylie, Calvin J S

    2011-01-01

    To provide generalized solutions if a given problem admits no actual solution is an important task in mathematics and the natural sciences. It has a rich history dating back to the early 19th century when Carl Friedrich Gauss developed the method of least squares of a system of linear equations - its solutions can be viewed as fixed points of averaged projections onto hyperplanes. A powerful generalization of this problem is to find fixed points of averaged resolvents (i.e., firmly nonexpansive mappings). This paper concerns the relationship between the set of fixed points of averaged resolvents and certain fixed point sets of compositions of resolvents. It partially extends recent work for two mappings on a question of C. Byrne. The analysis suggests a reformulation in a product space. Furthermore, two new algorithms are presented. A complete convergence proof that is based on averaged mappings is provided for the first algorithm. The second algorithm, which currently has no convergence proof, iterates a map...

  1. Time-resolved MR angiography with limited projections.

    Science.gov (United States)

    Huang, Yuexi; Wright, Graham A

    2007-08-01

    A method for reconstruction of time-resolved MRI called highly-constrained backprojection (HYPR) has been developed. To evaluate the HYPR reconstruction in relation to data sparsity and temporal dynamics, computer simulations were performed, investigating signal modulations under different situations that reflect dynamic contrast-enhanced MR angiography (MRA). In vivo studies were also performed with gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) for abdominal MRA in a canine model to demonstrate the application of HYPR for three-dimensional (3D) time-resolved MRA. When contrast dynamics vary over space, large vessels (e.g., veins) tend to introduce signal interference to small vessels (e.g., arteries) in HYPR, particularly when the vessels are in close proximity. The enhancement of background tissue signals may also alter the arterial and venous temporal profiles in HYPR. However, the artifacts are manifest as intensity modulation rather than structural interference, and therefore have little impact on structural diagnosis. Increasing the number of projections per time point increases temporal blur while reducing corruption of temporal behavior from adjacent tissues. Uniformly interleaved acquisition order, such as the bit-reversed order, is important to reduce artifacts. With high signal-to-noise ratio (SNR) and limited artifacts, HYPR reconstruction has potential to greatly improve time-resolved MRA in clinical practice.

  2. Resolving and measuring diffusion in complex interfaces: Exploring new capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Todd M. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    This exploratory LDRD targeted the use of a new high resolution spectroscopic diffusion capabilities developed at Sandia to resolve transport processes at interfaces in heterogeneous polymer materials. In particular, the combination of high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy with pulsed field gradient (PFG) diffusion experiments were used to directly explore interface diffusion within heterogeneous polymer composites, including measuring diffusion for individual chemical species in multi-component mixtures. Several different types of heterogeneous polymer systems were studied using these HRMAS NMR diffusion capabilities to probe the resolution limitations, determine the spatial length scales involved, and explore the general applicability to specific heterogeneous systems. The investigations pursued included a) the direct measurement of the diffusion for poly(dimethyl siloxane) polymer (PDMS) on nano-porous materials, b) measurement of penetrant diffusion in additive manufactures (3D printed) processed PDMS composites, and c) the measurement of diffusion in swollen polymers/penetrant mixtures within nano-confined aluminum oxide membranes. The NMR diffusion results obtained were encouraging and allowed for an improved understanding of diffusion and transport processes at the molecular level, while at the same time demonstrating that the spatial heterogeneity that can be resolved using HRMAS NMR PFG diffusion experiment must be larger than ~μm length scales, expect for polymer transport within nanoporous carbons where additional chemical resolution improves the resolvable heterogeneous length scale to hundreds of nm.

  3. Resolving bundled microtubules using anti-tubulin nanobodies.

    Science.gov (United States)

    Mikhaylova, Marina; Cloin, Bas M C; Finan, Kieran; van den Berg, Robert; Teeuw, Jalmar; Kijanka, Marta M; Sokolowski, Mikolaj; Katrukha, Eugene A; Maidorn, Manuel; Opazo, Felipe; Moutel, Sandrine; Vantard, Marylin; Perez, Frank; van Bergen en Henegouwen, Paul M P; Hoogenraad, Casper C; Ewers, Helge; Kapitein, Lukas C

    2015-08-11

    Microtubules are hollow biopolymers of 25-nm diameter and are key constituents of the cytoskeleton. In neurons, microtubules are organized differently between axons and dendrites, but their precise organization in different compartments is not completely understood. Super-resolution microscopy techniques can detect specific structures at an increased resolution, but the narrow spacing between neuronal microtubules poses challenges because most existing labelling strategies increase the effective microtubule diameter by 20-40 nm and will thereby blend neighbouring microtubules into one structure. Here we develop single-chain antibody fragments (nanobodies) against tubulin to achieve super-resolution imaging of microtubules with a decreased apparent diameter. To test the resolving power of these novel probes, we generate microtubule bundles with a known spacing of 50-70 nm and successfully resolve individual microtubules. Individual bundled microtubules can also be resolved in different mammalian cells, including hippocampal neurons, allowing novel insights into fundamental mechanisms of microtubule organization in cell- and neurobiology.

  4. Angle-resolved diffraction grating biosensor based on porous silicon

    Science.gov (United States)

    Lv, Changwu; Jia, Zhenhong; Liu, Yajun; Mo, Jiaqing; Li, Peng; Lv, Xiaoyi

    2016-03-01

    In this study, an optical biosensor based on a porous silicon composite structure was fabricated using a simple method. This structure consists of a thin, porous silicon surface diffraction grating and a one-dimensional porous silicon photonic crystal. An angle-resolved diffraction efficiency spectrum was obtained by measuring the diffraction efficiency at a range of incident angles. The angle-resolved diffraction efficiency of the 2nd and 3rd orders was studied experimentally and theoretically. The device was sensitive to the change of refractive index in the presence of a biomolecule indicated by the shift of the diffraction efficiency spectrum. The sensitivity of this sensor was investigated through use of an 8 base pair antifreeze protein DNA hybridization. The shifts of the angle-resolved diffraction efficiency spectrum showed a relationship with the change of the refractive index, and the detection limit of the biosensor reached 41.7 nM. This optical device is highly sensitive, inexpensive, and simple to fabricate. Using shifts in diffraction efficiency spectrum to detect biological molecules has not yet been explored, so this study establishes a foundation for future work.

  5. Advances and challenges in resolving the angiosperm phylogeny

    Directory of Open Access Journals (Sweden)

    Liping Zeng

    2014-01-01

    Full Text Available Angiosperm phylogenetics investigates the evolutionary history and relationships of angiosperms based on the construction of phylogenetic trees. Since the 1990s, nucleotide or amino acid sequences have been widely used for this and angiosperm phylogenetic analysis has advanced from using single or a combination of a few organellar genes to whole plastid genome sequences, resulting in the widely accepted modern molecular systematics of angiosperms. The current framework of the angiosperm phylogeny includes highly supported basal angiosperm relationships, five major clades (eudicots, monocots, magnoliids, Chloranthales, and Ceratophyllales, orders grouped within these clades, and core groups in the monocots or eudicots. However, organellar genes have some limitations; these involve uniparental inheritance in most instances and a relatively low percentage of phylogenetic informative sites. Thus, they are unable to resolve some relationships even when whole plastid genome sequences are used. Therefore, the utility of biparentally inherited nuclear genes with more information about evolutionary history, has gradually received more attention. Nevertheless, there are still some plant groups that are difficult to place in the angiosperm phylogeny, such as those involving the relative positions of the five major groups as well as those of several orders of eudicots. In this review, we discuss the applications, advantages and disadvantages of marker genes, the deep relationships that have been resolved in angiosperm phylogeny, groups with uncertain positions, and the challenges that remain in resolving an accurate phylogeny for angiosperms.

  6. Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity

    Energy Technology Data Exchange (ETDEWEB)

    Leite, Joao Paulo V. [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Bioquimica e Biologia Molecular; Braga, Fernao C.; Oliveira, Alaide B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia. Dept. de Produtos Farmaceuticos; Romussi, Giovanni [Universita degli Studi di Genova (Italy). Dipt. di Chimica e Tecnologie Farmaceutiche; Persoli, Rita M.; Tabach, Ricardo; Carlini, Elisaldo A. [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Dept. de Psicobiologia

    2010-07-01

    Maytenus ilicifolia Mart. ex Reissek is traditionally used in Brazil for treatment of gastric ulcers. Here we report the phytochemical investigation of an ethanol extract of M. ilicifolia leaves (EEMIL) aiming at the isolation of constituents which were used as chemical markers to monitor an activity-guided fractionation of a lyophilized aqueous extract of M. ilicifolia leaves (LAEMIL). From EEMIL, four flavonoids were isolated, namely the tri-flavonoid glycosides mauritianin (1), trifolin, (2) hyperin (4), and epi-catechin (5). Fractionation of LAEMIL led to 5 fractions which afforded the tetra-glycoside kaempferol derivative (3), and galactitol (6). LAEMIL and its fractions were evaluated in rats for their effects on gastric secretion volume and pH. HPLC (High Performance Liquid Chromatography) analysis revealed that only fractions containing the tri- and tetra-flavonoid glycosides 1 and 3 caused significant increase of gastric volume and pH, thus indicating that these glycosides play an important role on the gastroprotective effect of M.ilicifolia leaves. (author)

  7. Influences of emission sources and meteorology on aerosol chemistry in a polluted urban environment: results from DISCOVER-AQ California

    Science.gov (United States)

    Young, Dominique E.; Kim, Hwajin; Parworth, Caroline; Zhou, Shan; Zhang, Xiaolu; Cappa, Christopher D.; Seco, Roger; Kim, Saewung; Zhang, Qi

    2016-05-01

    The San Joaquin Valley (SJV) in California experiences persistent air-quality problems associated with elevated particulate matter (PM) concentrations due to anthropogenic emissions, topography, and meteorological conditions. Thus it is important to unravel the various sources and processes that affect the physicochemical properties of PM in order to better inform pollution abatement strategies and improve parameterizations in air-quality models. During January and February 2013, a ground supersite was installed at the Fresno-Garland California Air Resources Board (CARB) monitoring station, where comprehensive, real-time measurements of PM and trace gases were performed using instruments including an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) and an Ionicon proton transfer reaction time-of-flight mass spectrometer (PTR-TOF-MS) as part of the NASA Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) campaign. The average submicron aerosol (PM1) concentration was 31.0 µg m-3 and the total mass was dominated by organic aerosols (OA, 55 %), followed by ammonium nitrate (35 %). High PM pollution events were commonly associated with elevated OA concentrations, mostly from primary sources. Organic aerosols had average atomic oxygen-to-carbon (O / C), hydrogen-to-carbon (H / C), and nitrogen-to-carbon (N / C) ratios of 0.42, 1.70, and 0.017, respectively. Six distinct sources of organic aerosol were identified from positive matrix factorization (PMF) analysis of the AMS data: hydrocarbon-like OA (HOA; 9 % of total OA, O / C = 0.09) associated with local traffic, cooking OA (COA; 18 % of total OA, O / C = 0.19) associated with food cooking activities, two biomass burning OA (BBOA1: 13 % of total OA, O / C = 0.33; BBOA2: 20 % of total OA, O / C = 0.60) most likely associated with residential space heating from wood combustion, and semivolatile oxygenated OA (SV

  8. Mode resolved bend-loss analysis in few-mode fibers using spatially and spectrally resolved imaging

    DEFF Research Database (Denmark)

    Leandro, Lorenzo; Grüner-Nielsen, Lars Erik; Rottwitt, Karsten

    2015-01-01

    The increasing use of few-mode fibers for high-speed optical communication systems in space division multiplexing has created a need for mode resolved characterization of few-mode fibers. In this Letter, we present a new method to characterize the bend loss of the individual modes in a few-mode...... fiber. This procedure uses a simple setup for spatially and spectrally resolved imaging and allows the measurement of the bend loss of each and every guided mode at once. It does not require the use of mode converters in contrast to other methods. Results for graded-index two-and four-mode fibers...... are presented, together with comparisons against direct bend-loss measurements for the four-mode and standard single-mode fibers. (C) 2015 Optical Society of America...

  9. Gauge invariance in the theoretical description of time-resolved angle-resolved pump/probe photoemission spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Freericks, J. K.; Krishnamurthy, H. R.; Sentef, M. A.; Devereaux, T. P.

    2015-10-01

    Nonequilibrium calculations in the presence of an electric field are usually performed in a gauge, and need to be transformed to reveal the gauge-invariant observables. In this work, we discuss the issue of gauge invariance in the context of time-resolved angle-resolved pump/probe photoemission. If the probe is applied while the pump is still on, one must ensure that the calculations of the observed photocurrent are gauge invariant. We also discuss the requirement of the photoemission signal to be positive and the relationship of this constraint to gauge invariance. We end by discussing some technical details related to the perturbative derivation of the photoemission spectra, which involve processes where the pump pulse photoexcites electrons due to nonequilibrium effects.

  10. Range resolved measurements of atmospheric ozone and water vapour; Misure `range resolved` di ozono e vapor d`acqua

    Energy Technology Data Exchange (ETDEWEB)

    Barbini, R.; Colao, F.; Palucci, A.; Ribezzo, S.

    1992-12-31

    The ENEA (Italian Agency for New Technology, Energy and Environment) ground based lidar (Light Detection and Ranging) station, equipped with two TEA CO/sub 2/ laser transmitters, allows for range resolved measurements of minor atmospheric constituents or pollutants, using the DIAL differential absorption technique. This paper provides brief notes on the lidar station`s design characteristics and reports on the application of the instruments to obtain water vapour and ozone concentration profiles with a useful investigated range , R = 6 Km.

  11. BROADBAND TIME-RESOLVED E{sub p,i}-L{sub iso} CORRELATION IN GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Frontera, F.; Guidorzi, C. [Dipartimento di Fisica, Universita di Ferrara, Via Saragat 1, I-44100 Ferrara (Italy); Amati, L.; Landi, R. [INAF, Istituto di Astrofisica Spaziale e Fisica Cosmica, Bologna, Via Gobetti 101, I-40129 Bologna (Italy); In' t Zand, J., E-mail: frontera@fe.infn.it [Space Research Organization in the Netherlands, Sorbonnelaan 2, NL-3584 CA Utrecht (Netherlands)

    2012-08-01

    We report the results of a systematic study of the broadband (2-2000 keV) time-resolved prompt emission spectra of a sample of gamma-ray bursts (GRBs) detected with both Wide Field Cameras on board the BeppoSAX satellite and the BATSE experiment on board CGRO. In this first paper, we study the time-resolved dependence of the intrinsic peak energy E{sub p,i} of the E F(E) spectrum on the corresponding isotropic bolometric luminosity L{sub iso}. The E{sub p,i}-L{sub iso} relation or the equivalent relation between E{sub p,i} and the bolometric released energy E{sub iso}, derived using the time-averaged spectra of long GRBs with known redshift, is well established, but its physical origin is still a subject of discussion. In addition, some authors maintain that these relations are the result of instrumental selection effects. We find that not only a relation between the measured peak energy E{sub p} and the corresponding energy flux, but also a strong E{sub p,i} versus L{sub iso} correlation are found not only within each burst, but also are merging together the time-resolved data points from different GRBs. We do not expect significant instrumental selection effects that can affect the results obtained, apart from the fact that the GRBs in our sample are sufficiently bright to perform a time-resolved spectroscopy and that they have known redshift. If the fundamental physical process that gives rise to the GRB phenomenon does not depend on its brightness, we conclude that the E{sub p,i} versus L{sub iso} correlation found within each GRB is intrinsic to the emission process and that the correlations discovered by Amati et al. and Yonetoku et al. are likely not the result of selection effects. We also discuss the properties of the correlations found.

  12. ALMA observation of high-z extreme star-forming environments discovered by Planck/Herschel

    Science.gov (United States)

    Kneissl, R.

    2016-05-01

    The Comic Microwave Background satellite Planck with its High Frequency Instrument has surveyed the mm/sub-mm sky in six frequency channels from 100 to 900 GHz. A sample of 228 cold sources of the Cosmic Infrared Background was observed in follow-up with Herschel SPIRE. The majority of sources appear to be over-densities of star-forming galaxies matching the size of high-z proto-cluster regions, while a 3% fraction are individual bright, lensed galaxies. A large observing program is underway with the aim of resolving the regions into the constituent members of the Planck sources. First ALMA data have been received on one Planck/Herschel proto-cluster candidate, showing the expected large over-abundance of bright mm/sub-mm sources within the cluster region. ALMA long baseline data of the brightest lensed galaxy in the sample with > 1 Jy at 350 μm are also forthcoming.

  13. Digital Tracking Observations Can Discover Asteroids Ten Times Fainter than Conventional Searches

    CERN Document Server

    Heinze, Aren; Trollo, Joseph

    2015-01-01

    We describe digital tracking, a method for asteroid searches that greatly increases the sensitivity of a telescope to faint unknown asteroids. It has been previously used to detect faint Kuiper Belt objects using the Hubble Space Telescope and large ground-based instruments, and to find a small, fast-moving asteroid during a close approach to Earth. We complement this earlier work by developing digital tracking methodology for detecting asteroids using large-format CCD imagers. We demonstrate that the technique enables the ground-based detection of large numbers of new faint asteroids. Our methodology resolves or circumvents all major obstacles to the large-scale application of digital tracking for finding main belt and near-Earth asteroids. We find that for both asteroid populations, digital tracking can deliver a factor of ten improvement over conventional searches. Digital tracking has long been standard practice for deep Kuiper Belt surveys, but even there our methodology enables deeper integrations than ...

  14. First Science with SAMI: A Serendipitously Discovered Galactic Wind in ESO 185-G031

    CERN Document Server

    Fogarty, Lisa M R; Croom, Scott M; Green, Andrew W; Bryant, Julia J; Lawrence, Jon S; Richards, Samuel; Allen, James T; Bauer, Amanda E; Birchall, Michael N; Brough, Sarah; Colless, Matthew; Ellis, Simon C; Farrell, Tony; Goodwin, Michael; Heald, Ron; Hopkins, Andrew M; Horton, Anthony; Jones, D Heath; Lee, Steve; Lewis, Geraint; López-Sánchez, Ángel R; Miziarski, Stan; Trowland, Holly; Leon-Saval, Sergio G; Min, Seong-Sik; Trinh, Christopher; Cecil, Gerald; Veilleux, Sylvain; Kreimeyer, Kory

    2012-01-01

    We present the first scientific results from the Sydney-AAO Multi-Object IFS (SAMI) at the Anglo-Australian Telescope. This unique instrument deploys 13 fused fibre bundles (hexabundles) across a one-degree field of view allowing simultaneous spatially-resolved spectroscopy of 13 galaxies. During the first SAMI commissioning run, targeting a single galaxy field, one object (ESO 185-G031) was found to have extended minor axis emission with ionisation and kinematic properties consistent with a large-scale galactic wind. The importance of this result is two-fold: (i) fibre bundle spectrographs are able to identify low-surface brightness emission arising from extranuclear activity; (ii) such activity may be more common than presently assumed because conventional multi-object spectrographs use single-aperture fibres and spectra from these are nearly always dominated by nuclear emission. These early results demonstrate the extraordinary potential of multi-object hexabundle spectroscopy in future galaxy surveys.

  15. RESOLVE: Bridge between early lunar ISRU and science objectives

    Science.gov (United States)

    Taylor, G.; Sanders, G.; Larson, W.; Johnson, K.

    2007-08-01

    and make direct measurements. With this in mind, NASA initiated development of a payload named RESOLVE (Regolith & Environment Science and Oxygen & Lunar Volatile Extraction) that could be flown to the lunar poles and answer the questions surrounding the hydrogen: what's its form? how much is there? how deep or distributed is it? To do this, RESOLVE will use a drill to take a 1-2 meter core sample, crush and heat sample segments of the core in an oven and monitor the amount and type of volatile gases that evolve with a gas chromatograph (GC). RESOLVE will also selectively capture both hydrogen gas and water as a secondary method of quantification. A specialized camera that is coupled with a Raman spectrometer will allow core samples to be microscopically examined while also determining its mineral composition and possible water content before heating. Because RESOLVE is aimed at demonstrating capabilities and techniques that might be later used for ISRU, a multi-use oven is utilized with the ability to produce oxygen using the hydrogen reduction method. SCIENCE BENEFITS: In the process of answering the hydrogen question, the RESOLVE instrument suite will provide data that can address a number of other scientific questions and debate issues, especially the sources of volatiles and reactions that might take place in cold traps. It should be noted that the original instrument suite for RESOLVE was selected to accomplish the largest number of ISRU and science objectives as possible within the limited funding available. Complementary instruments are noted when additional science objectives can be accomplished. Incorporation of these new instruments into RESOLVE and potential partnerships is an area of near-term interest. Sources of Volatiles: The main proposed sources are episodic comet impacts, moreor- less continuous micrometeorite (both comet and asteroidal) impacts, solar wind bombardment, occasional volcanic emissions from the interior, and episodic delivery of

  16. The CUAHSI Water Data Center: Empowering scientists to discover, use, store, and share water data

    Science.gov (United States)

    Couch, A. L.; Hooper, R. P.; Arrigo, J. S.

    2012-12-01

    control. The WDC enables this by making both kinds of sources available in the same search interface. c. Data provenance: the appropriateness of data for use in a specific model or analysis often depends upon the exact details of how data was gathered and processed. The WDC will aid this by curating standards for metadata that are as descriptive as practical of the collection procedures. "Plug and play" sensor interfaces will fill in metadata appropriate to each sensor without human intervention. d. Contextual search: discovering data based upon geological (e.g. aquifer) or geographic (e.g., location in a stream network) features external to metadata. e. Data-driven search: discovering data that exhibit quality factors that are not described by the metadata. The WDC will partner with researchers desiring contextual and data driven search, and make results available to all. Many major data providers (e.g. federal agencies) are not mandated to provide access to data other than those they collect. The HIS project assembled data from over 90 different sources, thus demonstrating the promise of this approach. Meeting the grand challenges listed above will greatly enhance scientists' ability to discover, interpret, access, and analyze water data from across domains and sources to test Earth system hypotheses.

  17. Discovering biomedical semantic relations in PubMed queries for information retrieval and database curation.

    Science.gov (United States)

    Huang, Chung-Chi; Lu, Zhiyong

    2016-01-01

    Identifying relevant papers from the literature is a common task in biocuration. Most current biomedical literature search systems primarily rely on matching user keywords. Semantic search, on the other hand, seeks to improve search accuracy by understanding the entities and contextual relations in user keywords. However, past research has mostly focused on semantically identifying biological entities (e.g. chemicals, diseases and genes) with little effort on discovering semantic relations. In this work, we aim to discover biomedical semantic relations in PubMed queries in an automated and unsupervised fashion. Specifically, we focus on extracting and understanding the contextual information (or context patterns) that is used by PubMed users to represent semantic relations between entities such as 'CHEMICAL-1 compared to CHEMICAL-2' With the advances in automatic named entity recognition, we first tag entities in PubMed queries and then use tagged entities as knowledge to recognize pattern semantics. More specifically, we transform PubMed queries into context patterns involving participating entities, which are subsequently projected to latent topics via latent semantic analysis (LSA) to avoid the data sparseness and specificity issues. Finally, we mine semantically similar contextual patterns or semantic relations based on LSA topic distributions. Our two separate evaluation experiments of chemical-chemical (CC) and chemical-disease (CD) relations show that the proposed approach significantly outperforms a baseline method, which simply measures pattern semantics by similarity in participating entities. The highest performance achieved by our approach is nearly 0.9 and 0.85 respectively for the CC and CD task when compared against the ground truth in terms of normalized discounted cumulative gain (nDCG), a standard measure of ranking quality. These results suggest that our approach can effectively identify and return related semantic patterns in a ranked order

  18. Discovering Plate Boundaries Update: Builds Content Knowledge and Models Inquiry-based Learning

    Science.gov (United States)

    Sawyer, D. S.; Pringle, M. S.; Henning, A. T.

    2009-12-01

    Discovering Plate Boundaries (DPB) is a jigsaw-structured classroom exercise in which students explore the fundamental datasets from which plate boundary processes were discovered. The exercise has been widely used in the past ten years as a classroom activity for students in fifth grade through high school, and for Earth Science major and general education courses in college. Perhaps more importantly, the exercise has been used extensively for professional development of in-service and pre-service K-12 science teachers, where it simultaneously builds content knowledge in plate boundary processes (including natural hazards), models an effective data-rich, inquiry-based pedagogy, and provides a set of lesson plans and materials which teachers can port directly into their own classroom (see Pringle, et al, this session for a specific example). DPB is based on 4 “specialty” data maps, 1) earthquake locations, 2) modern volcanic activity, 3) seafloor age, and 4) topography and bathymetry, plus a fifth map of (undifferentiated) plate boundary locations. The jigsaw is structured so that students are first split into one of the four “specialties,” then re-arranged into groups with each of the four specialties to describe the boundaries of a particular plate. We have taken the original DPB materials, used the latest digital data sets to update all the basic maps, and expanded the opportunities for further student and teacher learning. The earthquake maps now cover the recent period including the deadly Banda Aceh event. The topography/bathymetry map now has global coverage and uses ice-free elevations, which can, for example, extend to further inquiry about mantle viscosity and loading processes (why are significant portions of the bedrock surface of Greenland and Antarctica below sea level?). The volcanic activity map now differentiates volcano type and primary volcanic lithology, allowing a more elaborate understanding of volcanism at different plate boundaries

  19. Parameterization of Frontal Symmetric Instabilities. I: Theory for Resolved Fronts

    Science.gov (United States)

    Bachman, S. D.; Fox-Kemper, B.; Taylor, J. R.; Thomas, L. N.

    2017-01-01

    A parameterization is proposed for the effects of symmetric instability (SI) on a resolved front. The parameterization is dependent on external forcing by surface buoyancy loss and/or down-front winds, which reduce potential vorticity (PV) and lead to conditions favorable for SI. The parameterization consists of three parts. The first part is a specification for the vertical eddy viscosity, which is derived from a specified ageostrophic circulation resulting from the balance of the Coriolis force and a Reynolds momentum flux (a turbulent Ekman balance), with a previously proposed vertical structure function for the geostrophic shear production. The vertical structure of the eddy viscosity is constructed to extract the mean kinetic energy of the front at a rate consistent with resolved SI. The second part of the parameterization represents a near-surface convective layer whose depth is determined by a previously proposed polynomial equation. The third part of the parameterization represents diffusive tracer mixing through small-scale shear instabilities and SI. The diabatic, vertical component of this diffusivity is set to be proportional to the eddy viscosity using a turbulent Prandtl number, and the along-isopycnal tracer mixing is represented by an anisotropic diffusivity tensor. Preliminary testing of the parameterization using a set of idealized models shows that the extraction of total energy of the front is consistent with that from SI-resolving LES, while yielding mixed layer stratification, momentum, and potential vorticity profiles that compare favorably to those from an extant boundary layer parameterization (Large et al., 1994). The new parameterization is also shown to improve the vertical mixing of a passive tracer in the LES.

  20. Lucas-Kanade fluid trajectories for time-resolved PIV

    Science.gov (United States)

    Yegavian, Robin; Leclaire, Benjamin; Champagnat, Frédéric; Illoul, Cédric; Losfeld, Gilles

    2016-08-01

    We introduce a new method for estimating fluid trajectories in time-resolved PIV. It relies on a Lucas-Kanade paradigm and consists in a simple and direct extension of a two-frame estimation with FOLKI-PIV (Champagnat et al 2011 Exp. Fluids 50 1169-82). The so-called Lucas-Kanade Fluid Trajectories (LKFT) are assumed to be polynomial in time, and are found as the minimizer of a global functional, in which displacements are sought so as to match the intensities of a series of images pairs in the sequence, in the least-squares sense. All pairs involve the central image, similar to other recent time-resolved approaches (FTC (Lynch and Scarano 2013 Meas. Sci. Technol. 24 035305) and FTEE (Jeon et al 2014 Exp. Fluids 55 1-16)). As switching from a two-frame to a time-resolved objective simply amounts to adding terms in a functional, no significant additional algorithmic element is required. Similar to FOLKI-PIV the method is very well suited for GPU acceleration, which is an important feature as computational complexity increases with the image sequence size. Tests on synthetic data exhibiting peak-locking show that increasing the image sequence size strongly reduces both associated bias and random error, and that LKFT has a remaining total error comparable to that of FTEE on this case. Results on case B of the third PIV challenge (Stanislas et al 2008 Exp. Fluids 45 27-71) also show its ability to drastically reduce the error in situations with low signal-to-noise ratio. These results are finally confirmed on experimental images acquired in the near-field of a low Reynolds number jet. Strong reductions in peak-locking, spatial and temporal noise compared to two-frame estimation are also observed, on the displacement components themselves, as well as on spatial or temporal derivatives, such as vorticity and material acceleration.