WorldWideScience

Sample records for biography as topic

  1. Magnus Hirschfeld, his biographies and the possibilities and boundaries of "biography" as "doing history.".

    Science.gov (United States)

    Brennan, Toni; Hegarty, Peter

    2009-12-01

    This article considers the two major biographies of sexologist Magnus Hirschfeld, MD (1868-1935), an early campaigner for "gay rights" avant la lettre. Like him, his first biographer Charlotte Wolff (1897-1986) was a Jewish doctor who lived and worked in Weimar Republic Berlin and fled Germany when the Nazi regime came to power. When researching Hirschfeld's biography (published in English in 1986) Wolff met a librarian and gay activist, Manfred Herzer, who would eventually be a cofounder of the Gay Museum in Berlin and publish (in German, in 1992) the other major Hirschfeld biography currently available. Using, inter alia, the correspondence between Wolff and Herzer, the article aims to explore and interrogate the boundaries and possibilities of "biography" as a form of "doing history." PMID:20422759

  2. Athletes confessions: the sports biography as an interaction ritual.

    Science.gov (United States)

    Thing, L F; Ronglan, L T

    2015-04-01

    Commercialization of emotions is not a new phenomenon but in Denmark there is a new general trend to tell and sell personal stories in the media. Personal deprivation and crises are also major topics in sports media. This paper focuses on sports biographies as a book genre that is reviving in popularity. The paper approaches the topic through the biographies of one Danish athlete: the former professional cyclist, Jesper Skibby, who writes about his doping disclosure and shares his personal dilemmas as a former elite sportsman. The thematic text analysis orientates around social interactions, emotions, and personality constructions. Inspired by microsociology with a Durkheimian flavor of Goffman and Hochschild, themes including "face work," "interaction rituals," and "emotions management" are discussed. The analysis claims that sharing personal information in the media is not only a means of confession and reclaiming status but is also business and management - on an intimate level. Telling the story of the corrosion of a sporting character has become a hot issue, an entertainment, and not least a commercial commitment. PMID:24673745

  3. Musicians as lifelong learners: 32 biographies

    NARCIS (Netherlands)

    Smilde, Rineke

    2009-01-01

    Within the study ‘Musicians as Lifelong Learners: Discovery through Biography’, biographical research was used to examine key developments in the professional lives of musicians, focusing on the relationship between their life, educational and career span ant their learning styles. This resulted in

  4. Arnold Hauser - a biography

    DEFF Research Database (Denmark)

    Larsen, Mihail

    It seems reasonable to regard Arnold Hauser's own biography in three different stories. First an official one, dealing with his public appearance through his publications. Another story has to be told about his personal life concentrating on his relationships with other intellectuals important to...... his biography. The last story deals with his self-estimation as an intellectual in a modern society....

  5. Biography-Driven Strategies as the Great Equalizer: Universal Conditions that Promote K-12 Culturally Responsive Teaching

    Directory of Open Access Journals (Sweden)

    Fanning, Cristina A.

    2012-05-01

    Full Text Available The growing number of culturally and linguistically diverse (CLD students entering our public school system demands a new pedagogical framework for teaching and learning. With its emphasis on all four dimensions of the CLD student biography (sociocultural, linguistic, cognitive, academic, biography-driven culturally responsive teaching (Herrera, 2010 addresses the limited attention currently devoted to second language learning issues in the literature and research related to culturally responsive pedagogy. This study investigates the use of biography-driven instructional (BDI strategies by 58 general education teachers at the elementary and secondary levels with CLD students in their classrooms using the Biography-Driven Performance Rubric, which measures enactment of teaching standards and educational best practices. Findings indicate that the use of BDI strategies can facilitate the practical actualization of culturallyresponsive teaching. Findings also suggest that implementation of BDI strategies can help teachers overcome challenges that are unique to secondary settings as they accommodate the assets and needs of CLD learners.

  6. Transnational biographies

    OpenAIRE

    Apitzsch, Ursula; Siouti, Irini

    2014-01-01

    "In this paper we discuss the concept of transnational biographies in migration studies. We use a biographical case study from the relatively new research field of advancement through education to explore that a transnational biography is not just a product of subjectivity but also a way of gaining access to invisible but nonetheless objective structures of transnational migration spaces. Our thesis is that the discovery and use of a transnational European educational space made it possible f...

  7. Difficulties of Biography Writing: A Philosophical Approach

    OpenAIRE

    TAŞDELEN, Vefa

    2014-01-01

    In this article can be also entitled “Difficulties of Biography Writing: A Philosophical Approach” what biography and biography writing means will be dealt with from a partly existentialist and hermeneutic view point by taking questions such as; “what is biography?”, “why human beings want to understand the other?”, “what is the nature of biography: is it history or literature?” into consideration. In this respect; knowledge value, art value, ethical value, existential value and educational v...

  8. Subjectivity as a play of territorialization: Exploring affective attachments to place through collective biography

    Czech Academy of Sciences Publication Activity Database

    Zábrodská, Kateřina; Ellwood, C.

    2011-01-01

    Roč. 21, č. 2 (2011), s. 180-191. ISSN 1210-3055 R&D Projects: GA ČR GPP407/10/P146 Institutional research plan: CEZ:AV0Z70250504 Keywords : collective biography * subjectivity * territorialization Subject RIV: AN - Psychology http://www.springerlink.com/content/27584v651qm45w41/

  9. Identity and biography as mediators of science and mathematics faculty's involvement in K-12 service

    Science.gov (United States)

    Skerrett, Allison; Sevian, Hannah

    2010-09-01

    This article explores aspects of science and mathematics faculty identities and biographies that mediated their involvement in K-12 service. Faculty expressed five motivations for participating in K-12 service—advancing their research agenda, advocating environmental consciousness, desiring to be involved in their children's schools, aspiring to improve their pedagogical practices and promoting equity and social justice.

  10. Exhibiting Mozart: Rethinking Biography

    OpenAIRE

    Spring, Ulrike

    2010-01-01

    Abstract: The article analyses the new permanent exhibition in the composer Wolfgang A. Mozart’s apartment in Vienna, opened in 2006, from the curator’s perspective. The exhibition presents an approach to biographical display in which the exhibited person becomes part of a multifaceted web of contexts, and the article argues for the active deployment of the polysemic character of objects as a means of grasping the complexity of a person’s biography. Presenting a concept for the...

  11. Freud and Literary Biography.

    Science.gov (United States)

    Ellman, Richard

    1984-01-01

    Sigmund Freud's attitudes about writing biographies of authors, and the influence of Freud's work on the interpretations of creativity, are discussed in relation to biographies of and by a number of writers. It is proposed that Freud's contributions, used carefully, have served to enlighten biography. (MSE)

  12. The biography of scientists as a means of communicating science: analogies concerning a hermeneutic or empirical problem

    Directory of Open Access Journals (Sweden)

    Maria Francisca Carneiro

    2007-10-01

    Full Text Available Sometimes scientists live real dramas or undergo social and psychological conflicts which have a positive or negative influence on the development and recognition of their research, discoveries and inventions in society, including the way they are recorded in history. This being so, the question is: to what extent can science be communicated to the public at large by the use of scientists' biographies as a motivational strategy? The controversy arises from the fact that usual (classical science has traditionally argued for the separation (or de-linking of the research (the object from the researcher (the subject.Thus, if the above-mentioned motivational strategy is used in scientific communication, it could break a dominant methodological trend and consequently lead to a questioning of the myth of axiological neutrality in science. The communication of science by means of scientists' biographies could be useful for reaching a specific public, more directed towards emotional aspects, thereby awakening its interest in science, even amid cultural differences and in environments where interest in science and its utility is lacking. It could also reveal human aspects of the everyday life of scientists, bringing them closer to the public at large, which would contribute to the dissemination of science and knowledge.

  13. Social Biography and Research.

    Science.gov (United States)

    Crepeau, Elizabeth Blesedell

    1997-01-01

    A researcher's life experiences cannot help but influence the research process. Including elements of one's social biography in research reports helps readers identify how a researcher's history and biases shaped the study. (SK)

  14. Travel as a Ritual toward Transformative Consciousness: Juxtaposing Che Guevara's Biography and Teacher Candidates' Narratives

    Science.gov (United States)

    Lea, YiShan

    2013-01-01

    This article discusses the development of critical consciousness by examining the biographical-narratives in relationship to the experiential accounts on travel. Biographical narratives are important cultural texts filled with history and cultural nuances. The biography of Ernesto Che Guevara has resonated with readers and viewers from around the…

  15. Encyclopedias of Astronomical Biographies - Status and Prospects --

    Science.gov (United States)

    Dick, W. R.

    Simple requests for biographies of famous astronomers can easily be satisfied. Short accounts of their lives are to be found in many books and encyclopedias. However, most of these sources are very incomplete, i. e.\\ do not provide information on less famous persons, and are not up to scientific standards. The most comprehensive sources of scientific biographies, Poggendorffs Biographisch-Literarisches Handwoerterbuch and Dictionary of Scientific Biography, are also not complete, partly not up-to-date and for most users not easily accessible. The most recent and most comprehensive dictionary of astronomical biography, containing 500 short entries, was written in Russian. Although a lot of information on biographies is available in publications, these are spread over thousands of volumes. There is no bibliography of these papers and books. During the last three years, short biographies of astronomers were also published in the World Wide Web. Some of these are on a very high scientific level. The author's collection of links to such WWW pages (http://www.astro.uni-bonn.de/~pbrosche/hist\\_astr/ ha\\_pers.html}) contains currently several thousand entries for more than 1200 persons related to the history of astronomy. This electronic ``encyclopedia'' in distributed form is now the most comprehensive and concentrated source for astronomical biographies. However, there are several problems arising from the electronic form of publication and from the uncoordinated and not always qualified efforts of the authors. The paper will discuss proposals, plans and first results of filling the gaps and increasing the quality, as well as some principal problems of writing short biographies and making them available to the public.

  16. Review Essay: Auto/Biography as Method: Dialectical Sociology of Everyday Life

    OpenAIRE

    Roth, Wolff-Michael

    2002-01-01

    Our Lives as Databases ist das Produkt eines Forschungsprojekts, in dem die teilnehmenden Autoren das kollektive Schreiben und Analysieren ihrer Autobiographien als Medium zum Praktizieren akademischer Soziologie benutzen. In diesem Beitrag beschreibe ich die Struktur und den Inhalt dieses ungewöhnlichen und sehr interessanten Buches und stelle meine Lesart anhand der exemplarischen Analyse eines der Kapitel dar. Obwohl der Herausgeber des Sammelbandes überzeugend für das kollektive Schreiben...

  17. Repurposing celecoxib as a topical antimicrobial agent

    Directory of Open Access Journals (Sweden)

    Mohamed N. Seleem

    2015-07-01

    Full Text Available There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, exhibits broad-spectrum antimicrobial activity against Gram-positive pathogens from a variety of genera, including Staphylococcus, Streptococcus, Listeria, Bacillus, and Mycobacterium, but not against Gram-negative pathogens. However, celecoxib is active against all of the Gram-negative bacteria tested, including strains of, Acinetobacter, and Pseudomonas, when their intrinsic resistance is artificially compromised by outer membrane permeabilizing agents such as colistin. The effect of celecoxib on incorporation of radioactive precursors into macromolecules in Staphylococcus aureus was examined. The primary antimicrobial mechanism of action of celecoxib was the dose-dependent inhibition of RNA, DNA, and protein synthesis. Further, we demonstrate the in vivo efficacy of celecoxib in a methicillin-resistant S. aureus (MRSA infected Caenorhabditis elegans whole animal model. Topical application of celecoxib (1 and 2% significantly reduced the mean bacterial count in a mouse model of MRSA skin infection. Further, celecoxib decreased the levels of all inflammatory cytokines tested, including tumor necrosis factor-α, interleukin-6, interleukin-1 beta, and monocyte chemo attractant protein-1 in wounds caused by MRSA infection. Celecoxib also exhibited synergy with many conventional antimicrobials when tested against four clinical isolates of S. aureus. Collectively, these results demonstrate that celecoxib alone, or in combination with traditional antimicrobials, has a potential to use as a topical drug for the treatment of bacterial skin infections.

  18. Tazarotene as alternative topical treatment for onychomycosis

    Directory of Open Access Journals (Sweden)

    Campione E

    2015-02-01

    Full Text Available Elena Campione,1 Evelin Jasmine Paternò,2 Gaetana Costanza,2,3 Laura Diluvio,1 Isabella Carboni,1 Daniele Marino,4 Cartesio Favalli,4 Sergio Chimenti,1 Luca Bianchi,1 Augusto Orlandi2,3 1Department of Dermatology, 2Department of Biomedicine and Prevention, 3Department of Anatomic Pathology, Policlinic Tor Vergata, 4Department of Microbiology, University of Rome Tor Vergata, Rome, Italy Background: Distal and lateral onychomycoses are the most frequent forms of onychomycosis, causing subungual hyperkeratosis that usually limits local penetration of antimycotic drugs. Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes. Given the well-documented efficacy of tazarotene on hyperkeratotic nail psoriasis, we investigated its therapeutic use in onychomycosis. Patients and methods: We designed a preliminary open clinical trial in patients affected by distal and lateral subungual onychomycosis of the toenails and verified the fungistatic activity of tazarotene in vitro. Fifteen patients were treated with topical tazarotene 0.1% gel once per day for 12 weeks. Mycological cultures and potassium hydroxide stains of nail samples were performed at the beginning and at the end of the study. Treatment was considered effective when clinical healing and negative mycological culture were obtained. Onycholysis, nail bed discoloration, and subungual hyperkeratosis were measured using standardized methodologies and analyzed by means of Mann–Whitney test and analysis of variance. Fungistatic activity of tazarotene was evaluated by disk diffusion assay. Results: Six patients (40% reached a mycological cure on target nail samples already after 4 weeks of treatment. Complete clinical healing and negative cultures were reached in all patients at week 12, with a significant improvement of all clinical parameters of the infected nails. Disk diffusion assay after 48 hours of incubation with

  19. Irrepressible Reformer: A Biography of Melvil Dewey.

    Science.gov (United States)

    Wiegand, Wayne A.

    This book is a biography of Melvil Dewey, the man behind the Dewey Decimal Classification System. Tracing Dewey's life and early influences that shaped it, the book explores Dewey's employment experiences, enterprises, and innovations and present a range of views on them; he was seen as an organizational genius but also as arrogant, manipulative,…

  20. The universe a biography

    CERN Document Server

    Gribbin, John

    2008-01-01

    The Universe: A Biography makes cosmology accessible to everyone. John Gribbin navigates the latest frontiers of scientific discovery to tell us what we really know about the history of the universe. Along the way, he describes how the universe began; what the early universe looked like; how its structure developed; and what emerged to hold it all together. He describes where the elements came from; how stars and galaxies formed; and the story of how life emerged. He even looks to the future: is the history of the universe going to end with a Big Crunch or a Big Rip.

  1. Bookshelf. John Adams biography

    International Nuclear Information System (INIS)

    Full text: When John Bertram Adams died on 3 March 1984, CERN lost one of its principal architects. The late Sir John Adams was a very private person who rarely confided in his colleagues. This made the job of his biographer particularly difficult. Michael Crowley- Milling has succeeded admirably, and has performed a very important service. Is it a potted history of CERN, or the story of the building of the PS, or of the SPS? Yes, all of these, but most of all it is a thoughtful and discerning biography and a fitting tribute to a veritable giant of European science and technology. The sub-title,' Engineer Extraordinary' refers not only to John's outstanding ability as a builder of accelerators, but perhaps even more importantly, as a builder of teams and an 'engineer of opinions'. The book describes how John's attention to detail and intuitive engineering skills developed during the early part of his career, when working in radar research, and how he emerged as a natural leader in the building of the CERN PS. Then later, how his statesmanship enabled him to ''...rescue it (the 300 GeV Programme) from seeming political disaster and nurse it through technical problems to a successful conclusion.'' One crucial part of this process described is the visit to CERN in 1970 by Margaret Thatcher, at that time UK Secretary of State for Education and Science, and her subsequent letters of thanks, not only to Bernard Gregory as Director General, but also to John. It is interesting to speculate to what extent the good impression made on that occasion helped many years later, when as Prime Minister Mrs Thatcher decided that Britain should stay in CERN! After the successful commissioning of the SPS, the book goes on to describe the period when the two CERN Laboratories were merged under two Directors General. Unfortunately I found this part a little too low key, given that John and Leon van Hove presided over what was undoubtedly

  2. Telling Lives in Science: Essays on Scientific Biography

    International Nuclear Information System (INIS)

    This collection of ten essays by historians of science, several of them biographers, is concerned with the role of scientific biography in forming conceptions of science and scientists. The essays include studies of the biographies of individual scientists, assessments of the aims and style of scientific portraits in different historical contexts, examinations of changing biographical interpretations of scientists, and much discussion of the methodological issues involved in the writing of scientific biographies. Many historians consider biography to be an ambiguous genre, its appeal based on nostalgia rather than history, with a focus on personality rather than historical context, but the biographer can reply that scientific biography reveals the practice of science at its most fundamental level. Indeed, scientific biography has provided a powerful medium in which public conceptions of science have been established. Einstein observed that 'the essential being of a man of my type lies in what he thinks and how he thinks', and his Autobiographical Notes suppress personality in favour of physics. But the biographer may see matters differently, and wish to integrate the public and the private life of the scientist. In their substantial introduction the editors discuss these and other problems, and the book is directed to the professional concerns of historians of science. While there is little here on the history of physics, Geoffrey Cantor's essay on public images of Faraday as constructed in popular biographies, a discussion of conflicting portraits of Faraday as romantic genius or hard-working slogger, may interest readers of this journal. (book review)

  3. Albert Einstein a biography

    CERN Document Server

    Fölsing, Albrecht

    1997-01-01

    Albert Einstein's achievements are not just milestones in the history of science; decades ago they became an integral part of the twentieth-century world in which we live. Like no other modern physicist he altered and expanded our understanding of nature. Like few other scholars, he stood fully in the public eye. In a world changing with dramatic rapidity, he embodied the role of the scientist by personal example. Albrecht Folsing, relying on previously unknown sources and letters, brings Einstein's "genius" into focus. Whereas former biographies, written in the tradition of the history of science, seem to describe a heroic Einstein who fell to earth from heaven, Folsing attempts to reconstruct Einstein's thought in the context of the state of research at the turn of the century. Thus, perhaps for the first time, Einstein's surroundings come to light.

  4. Wilhelm Conrad Roentgen: A biography; Wilhelm Conrad Roentgen: Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Leicht, H.

    1994-12-31

    The author of this biography attempts to throw some light on the personality of Wilhelm Roentgen. The book describes how Roentgen gained celebrity for his discoveries, but also the problems he encountered in his early scientific career. (orig.) [Deutsch] In der Biographie laesst der Autor den menschlichen Zuegen Roentgens breiten Raum. Das Buch schildert, wie Roentgen aufgrund seiner Entdeckung Beruehmtheit erlangte. Es zeigt jedoch nicht nur die Hoehepunkte im Leben Roentgens, sondern auch seinen schweren Weg zum Wissenschaftler. (orig.)

  5. Re-Writing Composers' Lives: Critical Historiography and Musical Biography

    OpenAIRE

    Wiley, Christopher

    2008-01-01

    Recent musicological discourse, while frequently considering issues of historiography and canonicity, has seldom critically engaged with biography as a genre of documentary significance to reception history for its attempts to shape public opinion of its subjects. In consequence, modern musicology has often taken for granted many tendencies and preoccupations that accumulated in musical biography in the late nineteenth and early twentieth centuries. This thesis presents a historiographical ex...

  6. Julius Petersen 1839-1910. A Biography

    DEFF Research Database (Denmark)

    Lützen, Jesper; Sabidussi, Gert; Toft, Bjarne

    1992-01-01

    A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics.......A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics....

  7. Ethnomusicological biography of the traditional folk musician: Biography of the gusle-player

    Directory of Open Access Journals (Sweden)

    Lajić-Mihajlović Danka

    2008-01-01

    Full Text Available With the development of ethnomusicology from a comparative discipline to an anthropologically oriented science there has been an increase in the significance of the biography of folk musicians as scientific sources. The intention of the anthropological thought to accept and theoretically consider human nature as open and dynamic, has been realized in the ethnomusicological plane through the understanding of music as a product of thinking and behaviour of a particular musician in given circumstances. The concept of an artist is especially complex in the field of oral music culture, where creation and performance are connected in one person and the transferring process involves direct communication. The attempt to overcome the dichotomy of the musicological and sociological, i. e. anthropological attitude in ethnomusicology by synthesizing concepts which involve music, culture and man has brought particular importance to the relations between individual biographies and 'biographies of the collective' - relevant historical ethnological, anthropological, sociological, culturological, religion ideological and other types of data. Observations enlightening the social side of the folk musician's personality make the necessary 'frame' for the biography: from 'objective' social circumstances which modelled it to the opinion of the cultural environment about his performing. The folk musician's biography oriented towards ethnomusicology involves the result of a critical evaluation of the picture based on the emic and ethic vision autobiographical data and the observations of others, primarily researchers. The complexity of a biographical discourse in ethnomusicology can be perfectly seen in the example of the gusle-player's biography, as a genre-determined solo role in the tradition. For studying the relation between a person and a style of music expression, concerning gusle-players it is important to bear in mind the change in the profile of gusle

  8. LIQUID CRYSTAL AS ACCELERANT IN DRUG ABSORPTION FROM TOPICAL FORMULATIONS

    Directory of Open Access Journals (Sweden)

    Trivedi Nirali

    2011-04-01

    Full Text Available Topical drug delivery has been one of the major research fields in the area of drug therapy for last few decades. However inspite of its large therapeutic potential market success has been limited. It provides the several advantages over the oral drug delivery. Percutaneous absorption involves the passage of the drug molecule from the skin surface into the stratum corneum under the influence of a concentration gradient and its subsequent diffusion through the stratum corneum and underlying epidermis, through the dermis, and into the blood circulation. Liquid crystal phase has emerged as a novel material for preparation of topical drug delivery systems. It fulfills the requirements for making drug loading and drug absorption faster from the site of application of topical formulations. Liquid crystal has got many phases in itself which can be further exploited to get a better and more efficient drug delivery system. Also a variety of areas in medical and electronics streamline can find its application. There is also a wide scope in respect to the methods by which these liquid crystals can be prepared. Different methods give rise to different kinds of liquid crystals. Topical formulations have emerged as a very useful drug delivery system as it bypasses the first pass metabolism. Also the absorption of drugs depends on the percutaneous absorption of drug from the area of application. Hence it’s required to choose such a vehicle which enhances the absorption of drug from the formulation.

  9. Topical tranexamic acid as a promising treatment for melasma

    OpenAIRE

    Bahareh Ebrahimi; Farahnaz Fatemi Naeini

    2014-01-01

    Background: In recent times, tranexamic acid (TA) is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty...

  10. Topical tranexamic acid as a promising treatment for melasma

    Directory of Open Access Journals (Sweden)

    Bahareh Ebrahimi

    2014-01-01

    Full Text Available Background: In recent times, tranexamic acid (TA is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12. Results: A repeated measurement analysis was used to evaluate the changes in the MASI score before and after treatments. A significant decreasing trend was observed in the MASI score of both groups with no significant difference between them during the study (P < 0.05. No differences were seen in patients′ and investigator′s satisfaction of melasma improvement between two groups (P < 0.05. However, the side effects of hydroquinone + dexamethasone were significantly prominent compared with TA (P = 0.01. Conclusion: This study′s results introduce the topical TA as an effective and safe medication for the treatment of melasma.

  11. Virgil: Reception and the Myth of Biography

    OpenAIRE

    Laird, Andrew

    2009-01-01

    Ideas of Virgil´s `reception´ and of his mythical `biography´ can both be illuminated by an exploration of Virgil´s role as a constructed character in his own poetry. The consensus between some earlier Roman responses to Virgil and the traditions of commentary on the poet from later in antiquity informs the following discussion of the poet´s individual presence in the performance and reception of his work. Earlier sources, which show an interest in the development of Virgil´s work...

  12. Gauß eine Biographie

    CERN Document Server

    Mania, Hubert

    2009-01-01

    Daniel Kehlmann hat ihn wiederentdeckt, den bedeutendsten Mathematiker der Neuzeit: Karl Friedrich Gauß (1777 1855). Seine überragenden wissenschaftlichen Leistungen waren schon seinen Zeitgenossen bewusst. Da Gauß jedoch nur einen Bruchteil seiner Entdeckungen veröffentlichte, erschloss sich erst der Nachwelt die Tiefgründigkeit und Reichweite seines Werks. Hubert Mania schildert in dieser ersten umfassenden Biographie die Geschichte eines genialen Wissenschaftlers und zugleich eine ganze Epoche. Gauß war ein Mann, der in einer Welt des Aufbruchs völlig zurückgezogen lebte. Dabei hat er wie kaum ein anderer unsere Sicht der Welt revolutioniert. Als Erster formulierte er eine nichteuklidische Geometrie und schuf damit die unentbehrliche Grundlage zu Einsteins Entwicklung der allgemeinen Relativitätstheorie. Eine glänzend geschriebene Biographie des weltberühmten und doch so unbekannten Genies Karl Friedrich Gauß.

  13. Notes on the Method of World-System Biography

    Directory of Open Access Journals (Sweden)

    Kevan Harris

    2015-08-01

    Full Text Available C. Wright Mills boiled the social sciences down to one sentence: “They are attempts to help us understand biography and history, and the connections between the two in a variety of social structures.” This special issue considers biography as an fruitful entry point into macro-historical sociology. With lineages from Marx and Weber to Wallerstein and Bourdieu, the sociology of the individual can produce a clearer path between the muddy oppositions of structure and agency or the longue durée and the event. This special issue unbinds biography from methodological nationalism and the teleology of great men tales. Instead, we aim to show how individuals are "a world within a world," an acting subject structured within world historical time and place.

  14. Notes on the Method of World-System Biography

    OpenAIRE

    Kevan Harris; Brendan McQuade

    2015-01-01

    C. Wright Mills boiled the social sciences down to one sentence: “They are attempts to help us understand biography and history, and the connections between the two in a variety of social structures.” This special issue considers biography as an fruitful entry point into macro-historical sociology. With lineages from Marx and Weber to Wallerstein and Bourdieu, the sociology of the individual can produce a clearer path between the muddy oppositions of structure and agency or the longue durée a...

  15. Topical fluoride as a cause of dental fluorosis in children

    OpenAIRE

    Wong, MCM; Lo, ECM; Glenny, AM; Tsang, BWK; Worthington, HV; Marinho, VCC

    2009-01-01

    BACKGROUND: For many years, topical use of fluorides has gained greater popularity than systemic use of fluorides. A possible adverse effect associated with the use of topical fluoride is the development of dental fluorosis due to the ingestion of excessive fluoride by young children with developing teeth. OBJECTIVES: To describe the relationship between the use of topical fluorides in young children and the risk of developing dental fluorosis. SEARCH STRATEGY: Electronic search of the Cochra...

  16. Elastic vesicles as topical/transdermal drug delivery systems.

    Science.gov (United States)

    Choi, M J; Maibach, H I

    2005-08-01

    Skin acts a major target as well as a principle barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been assessed to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Elastic vesicles are classified with phospholipid (Transfersomes((R)) and ethosomes) and detergent-based types. Elastic vesicles were more efficient at delivering a low and high molecular weight drug to the skin in terms of quantity and depth. Their effectiveness strongly depends on their physicochemical properties: composition, duration and application volume, and entrapment efficiency and application methods. This review focuses on the effect of elastic liposomes for enhancing the drug penetration and defines the action mechanism of penetration into deeper skin. PMID:18492190

  17. Olive Banks and the Collective Biography of British Feminism

    Science.gov (United States)

    Weiner, Gaby

    2008-01-01

    This paper considers Olive Banks' work on charting the history and development of British feminism, and particularly her use of collective biography as a research and analytic tool. It is argued that while this has been seen as the least "fashionable" aspect of her work, it took forward C. Wright Mills' contention for one definition of sociology…

  18. Albert einstein - Illustrated biography

    International Nuclear Information System (INIS)

    A genius of science, but also a great-hearted man who fought his convictions all his life long. That is the Albert Einstein s portrait what draw the documents collected in this book: photographies, talks, letters and narrations, sometimes unpublished. With evidences and anecdotes is drawn a surprising personality of a man full of humor and originality who made his mark, as nobody else, in this tumultuous century. (N.C.)

  19. Biographies

    OpenAIRE

    2014-01-01

    DANIÈLE BERTON-CHARRIÈRE Danièle Berton-Charrière est professeur à l’université Blaise Pascal de Clermont- Ferrand. Spécialiste du théâtre élisabéthain et jacobéen, elle a soutenu une thèse d’État sur Cyril Tourneur. Ses travaux de recherche portent sur le théâtre (jusqu’à l’époque contemporaine), l’intertextualité et l’intersémioticité. Elle a co-dirigé Expression contemporaine et représentation (s) dans le théâtre anglophone (2006) et Création théâtrale : schèmes, traduction, adaptation (20...

  20. A Biography of Henri Poincar\\'e - 2012 Centenary of the Death of Poincar\\'e

    CERN Document Server

    Weinstein, Galina

    2012-01-01

    On January 4, 2012, the centenary of Henri Poincar\\'e's death, a colloquium was held in Nancy, France the subject of which was "Vers une biographie d'Henri Poincar\\'e". Scholars discussed several approaches for writing a biography of Poincar\\'e. In this paper I present a personal and scientific biographical sketch of Poincar\\'e, which does not in any way reflect Poincar\\'e's rich personality and immense activity in science: When Poincar\\'e traveled to parts of Europe, Africa and America, his companions noticed that he knew well everything from statistics to history and curious customs and habits of peoples. He was almost teaching everything in science. He was so encyclopedic that he dealt with the outstanding questions in the different branches of physics and mathematics; he had altered whole fields of science such as non-Euclidean geometry, Arithmetic, celestial mechanics, thermodynamics and kinetic theory, optics, electrodynamics, Maxwell's theory, and other topics from the forefront of Fin de Si\\`ecle phys...

  1. WILLIAM GURNEE SINNIGEN - 20TH CENTURY CLASSICIST AND ROMAN HISTORIAN: BIOGRAPHY & BIBLIOGRAPHY

    Directory of Open Access Journals (Sweden)

    Matthew Gray Marsh

    2016-04-01

    Full Text Available William Gurnee Sinnigen was a Classicist and Roman historian, active in the mid-to-late 20th century. Trained at the University of Michigan by noted Roman administrative historian Arthur E. R. Boak, Sinnigen continued his mentor’s work in administrative history, producing several articles on different aspects of Roman and Byzantine administrative topics.  Sinnigen was also responsible for the revision and update of Boak’s acclaimed textbook on Roman history, as well as Charles Alexander Robinson’s textbook on Ancient history.  This article will provide a brief biography of Professor Sinnigen, along with a bibliography of his published works and reviews by other scholars of his work.

  2. Encouraging adolescents toward Mental Health Careers via Website Biographies

    OpenAIRE

    Willcockson, Irmi; Shankar, Prabhu R.V.; Cynthia L. Phelps; Johnson, Craig W.

    2003-01-01

    This project designed, developed, implemented and evaluated the effectiveness of an interactive, multi-media website designed to encourage adolescents to consider careers in mental health. This Web-based learning environment features biographies of mental health scientists. Evaluation is conducted in a systematic, structured way using cognitive achievement, usability (ease of use), and affective scales (e.g., fun to use) as outcome measures.

  3. Nuclear pursuits: The scientific biography of Wilfrid Bennett Lewis

    International Nuclear Information System (INIS)

    The scientific life of Wilfrid Bennett Lewis. The biography covers Lewis's role in the development of radar, his tenure as the Chief Superintendent of the Telecommunications Research Establishment at Malvern through his heading of the then fledgling Canadian nuclear research facility in Chalk River, Ontario. Lewis's drive, intelligence, and remarkable organizational skills placed him at the forefront of Canada's nuclear program. His influence lead to a collaboration between Atomic Energy of Canada Limited and Ontario Hydro that ultimately resulted in the development of the CANDU reactor. His influence was also profound in the near by town of Deep River with one prime legacy being the W.B. Lewis Library. Lewis's bibliography is included in the biography

  4. A biography of Wolfgang Ernest Pauli

    International Nuclear Information System (INIS)

    This article presents a short biography of Pauli in which we find the most important facts of his scientific career and some stunning sides of his personality. Pauli was born in 1900 in Vienna in an intellectual family. He was very soon interested in physics. At the age of 21 he published a relevant article on relativity, and the same year he presented a doctorate thesis on the quantum description of the H2+ molecular ion. As soon as 1925, Pauli discovered the exclusion principle (for which he will receive the Nobel prize in 1945), and was the first to calculate the energy levels of the hydrogen atom by using the Heisenberg formalism. In 1930, he suggested the existence of an unknown particle (the neutrino) to explain the continuous spectrum of the beta decay. In 1934, he found a link between the spin and the quantum statistics that is now called the spin-statistic theorem. Pauli died in december 1958 from a pancreas tumor. (A.C.)

  5. Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy

    DEFF Research Database (Denmark)

    Salale, Nesrin; Treldal, Charlotte; Mogensen, Stine;

    2014-01-01

    Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult...... lidocaine spray proved to be a superior option as topical pharyngeal anesthetic before an UGE....

  6. Selected translations and analysis of "Further biographies of nuns"

    OpenAIRE

    2008-01-01

    ‘Further Biographies of Nuns’ was compiled by Master Zhenhua (1908 -1947) in the 1940s and presents the biographies of 200 Buddhist nuns from the Liang Dynasty (502-557) to the Republic of China (1912-1949). This thesis presents the translation of twelve biographies from ‘Further Biographies of Nuns.’ Though the Buddhist monks of China have been a source for many biographies and studies by both Asian and Western scholars throughout history, Chinese Buddhist nuns have received little atte...

  7. Silver Nanoparticles as Real Topical Bullets for Wound Healing

    OpenAIRE

    Gunasekaran, Thirumurugan; Nigusse, Tadele; Dhanaraju, Magharla Dasaratha

    2012-01-01

    Nanotechnology is on the threshold of providing a host of new materials and approaches, revolutionizing the medical and pharmaceutical fields. Several areas of medical care are already profiting from the advantage that nanotechnology offers. Recently, silver nanoparticles are attracting interest for a clinical application because of its potential biological properties such as antibacterial activity, anti-inflammatory effects, and wound healing efficacy, which could be exploited in developing ...

  8. Bexarotene Topical

    Science.gov (United States)

    ... condition may improve as soon as 4 weeks after you begin to use topical bexarotene, or it may ... notice any improvement. Continue to use topical bexarotene after you notice improvement; your condition may continue to improve. ...

  9. Clinical use of topical thrombin as a surgical hemostat

    Directory of Open Access Journals (Sweden)

    Wesley K Lew

    2008-08-01

    Full Text Available Wesley K Lew1, Fred A Weaver21University of Southern California, Department of Surgery, Los Angeles, CA, USA; 2CardioVascular Thoracic Institute at the University of Southern California, Los Angeles, CA, USAAbstract: When surgical ligation of bleeding fails, or is not possible, surgeons rely on a number of hemostatic aids, including thrombin. This review discusses the history, pharmacology and clinical application of thrombin as a surgical hemostat. The initial thrombin was bovine in origin, but its use has been complicated by the formation of antibodies that cross react with human coagulation factors. This has been associated with life threatening bleeding and in some circumstances anaphylaxis and death. Human thrombin, isolated from pooled plasma of donors, has been developed in an effort to minimize these risks, but its downside is the potential of transmitting blood-borne pathogens and limited availability. Recently a recombinant thrombin has been developed and approved for use by the FDA. It has the advantage of being minimally antigenic and devoid of the risk if viral transmission. Thrombin is often used in conjunction with other hemostatic aids, including absorbable agents (like gelfoam, collagen, and cellulose, and with fibrinogen in fibrin glues. The last part of this review will discuss these agents in detail, and review their clinical applications.Keywords: bovine, recombinant, human, thrombin, antigenicity, antibodies

  10. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2011-04-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  11. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2012-02-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  12. Viscoelastic evaluation of topical creams containing microcrystalline cellulose/sodium carboxymethyl cellulose as stabilizer

    OpenAIRE

    Adeyeye, Moji Christianah; Jain, Ashwinkumar C.; Ghorab, Mohamed K. M.; Reilly, William J.

    2002-01-01

    The purpose of this study was to examine the viscoelastic properties of topical creams containing various concentrations of microcrystalline cellulose and sodium carboxymethyl cellulose (Avicel® CL-611) as a stabilizer. Avicel CL-611 was used at 4 different levels (1%, 2%, 4%, and 6% dispersion) to prepare topical creams, and hydrocortisone acetate was used as a model drug. The viscoelastic properties such as loss modulus (G), storage modulus (G), and loss tangent (tan δ) of these creams were...

  13. An experimental 'Life' for an experimental life: Richard Waller's biography of Robert Hooke (1705).

    Science.gov (United States)

    Moxham, Noah

    2016-03-01

    Richard Waller's 'Life of Dr Robert Hooke', prefixed to his edition of Hooke's Posthumous Works (1705), is an important source for the life of one of the most eminent members of the early Royal Society. It also has the distinction of being one of the earliest biographies of a man of science to be published in English. I argue that it is in fact the first biography to embrace the subject's natural-philosophical work as the centre of his life, and I investigate Waller's reasons for adopting this strategy and his struggle with the problem of how to represent an early experimental philosopher in print. I suggest that Waller eschews the 'Christian philosopher' tradition of contemporary biography - partly because of the unusually diverse and fragmentary nature of Hooke's intellectual output - and draws instead upon the structure of the Royal Society's archive as a means of organizing and understanding Hooke's life. The most quoted phrase from Waller's biography is that Hooke became 'to a crime close and reserved' in later life; this essay argues that Waller's biographical sketch was fashioned in order to undo the effects of that reserve. In modelling his approach very closely on the structure of the society's records he was principally concerned with making Hooke's work and biography accessible, intelligible and useful to the fellowship in a context familiar to them, a context which had provided the institutional framework for most of Hooke's adult life. I argue that Waller's 'Life' was also intended to make the largest claims for Hooke's intellectual standing that the author dared in the context of the enmity between Hooke and Isaac Newton once the latter became president of the Royal Society. However, I also adduce fresh manuscript evidence that Waller actually compiled, but did not publish, a defence of Hooke's claim to have discovered the inverse square law of gravity, allowing us to glimpse a much more assertive biography of Hooke than the published version. PMID

  14. Musicians as lifelong learners: discovery through biography

    NARCIS (Netherlands)

    Smilde, Rineke

    2009-01-01

    Today musicians face major changes in their professional life, confronted with questions of how to function flexibly and exploit opportunities in the rapidly changing cultural context. To this end, the concept of lifelong learning is being investigated within this study. Biographical research into

  15. Topical cyclosporin as an alternative treatment for vision threatening blepharokeratoconjunctivitis: a case report

    Directory of Open Access Journals (Sweden)

    Ismail AS

    2012-06-01

    Full Text Available Abdul-Salim Ismail,1,2 Rohana Taharin,2 Zunaina Embong11Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 2Department of Ophthalmology, Hospital Pulau Pinang, Jalan Resindensi, Pulau Pinang, MalaysiaAbstract: Here, a case of vision threatening blepharokeratoconjunctivitis that responded well to topical cyclosporin is reported. A 9-year-old Malay girl with a history of bilateral blepharokeratoconjunctivitis was regularly treated with lid scrubbing using diluted baby shampoo, fusidic acid gel, and topical steroids as well as an intermittent course of oral doxycycline for the past year. She developed acute onset bilateral eye redness associated with poor vision in her right eye. Both eyes showed marked diffuse hyperemic conjunctiva with corneal vascularization. The presence of corneal vascularization obscured the visual axis in the right eye. The condition did not improve with regular intensive lid hygiene using diluted baby shampoo, fusidic acid gel, and topical steroids. She was started on topical cyclosporin A 0.5% every 6 hours. There was a dramatic regression of corneal vascularization after 3 days on topical cyclosporin, with marked improvement in visual acuity. This is a single case in which cyclosporin improved the status of the ocular surface. A large cohort study is required to justify its effectiveness in treating blepharokeratoconjunctivitis and to test its potential as an alternative immunosuppressive agent in comparison to conventional corticosteroids.Keywords: blepharokeratoconjunctivitis, cyclosporin

  16. The Gendering of Albert Einstein and Marie Curie in Children's Biographies: Some Tensions

    Science.gov (United States)

    Wilson, Rachel E.; Jarrard, Amber R.; Tippins, Deborah J.

    2009-01-01

    Few twentieth century scientists have generated as much interest as Albert Einstein and Marie Currie. Their lives are centrally depicted in numerous children's biographies of famous scientists. Yet their stories reflect interesting paradoxes and tacit sets of unexplored sociocultural assumptions about gender in science education and the larger…

  17. Biography of Stuart Lindsay Biography of Stuart Lindsay

    Science.gov (United States)

    Tao, Nongjian; Nagahara, Larry; Thundat, Thomas; Zhang, Peimeng

    2012-04-01

    Stuart received his BSc and PhD in physics from the University of Manchester in 1972 and 1976, respectively. After a brief period working in the Phillips Labs, he joined Arizona State University (ASU) as a faculty member in 1979. While much of his current interest is in the molecular basis of diseases, Stuart has made long-lasting contributions to several fields in nanotechnology and biophysics over his past three decades at ASU. He was the first to develop inelastic light scattering spectroscopy to study low frequency vibration modes in DNA, which has led to a better understanding of collective motions in DNA and A-B transition in DNA. The early stages of his scientific career at ASU also included studying materials under extremely high pressure, glass transitions and the light scattering of semiconductor materials. He pioneered the scanning probe microscopy imaging of DNA and other biological molecules in water. His unusual talent in experimental physics and instrumentation led to the development of a 9-pass Fabry-Perot for high-resolution optical spectroscopy and a variety of innovative technologies for scanning probe microscopy. He co-founded the Molecular Imaging Corporation (now acquired by Agilent). In addition to biological molecules, Stuart is one of the pioneers who applied scanning tunneling microscopy to studying fundamental phenomena at solid-liquid interfaces, including charge transport, interfacial forces and molecular adsorption in solutions. His seminal work in single molecule electron transport provides new insights into not only the mechanism of the scanning tunneling microscopy of molecules, but also molecular electronics. Stuart's contribution to science goes beyond the original research mentioned above. His passion and energy for science have inspired and influenced many younger scientists, including his students, postdoctoral researchers and junior faculty. We wish Stuart many more happy, healthy and productive years ahead.

  18. Being Teddy Roosevelt: Exploring Biographies and Overcoming Life's Obstacles

    Science.gov (United States)

    Zarnowski, Myra

    2008-01-01

    In this article, the author demonstrates how students can use biographies in developing their own personal strengths of character. Because biographies raise issues in context, they provide excellent material for thinking about character traits. Books like those discussed in this article show how people living in actual situations made decisions…

  19. GENDER AND THE PERSONAL IN POLITICAL BIOGRAPHY Observations from a Dutch Perspective

    NARCIS (Netherlands)

    Bosch, Mineke

    2009-01-01

    This article explores the differential meanings of "personal life" in political biographies of men and women, mainly based upon Dutch examples, but making use of international literature. Though there has been a tendency to use personal detail only as a means to advertise and popularize old-fashione

  20. The Cultural Biography of Agarwood

    OpenAIRE

    Jung, Dinah

    2013-01-01

    The intangible heritage of making fine use of agarwood is a story of exceptional refinement, concerning arts and (syn-) aesthetic sensitivity, as well as a story of valuing and employing nature, commercialisation, and of the search for identity within the multicultural entanglements of Asia. Its continuation presents a challenge in business, scientific and cultural regards. CONTENTS: I. Portrayal of the aromatic material – II. Early perfumery arts and exotic stimuli – III. Supraregional ...

  1. Maria Montessori--A Biography.

    Science.gov (United States)

    Ellicott, Barbara Ann

    This brief biographical sketch of Maria Montessori focuses on her philosophy of learning and her methods of teaching. Her holistic approach to education is discussed in the light of its impact on educational theories and practices in the early 1900s. Included in this discussion is a description of her theories, such as the developmental stages of…

  2. Dr. Carson K. Eoyang, Biography

    OpenAIRE

    Eoyang, Carson K.

    2013-01-01

    Dr. Carson K. Eoyang Emeritas Professor Naval Postgraduate School Dr. Eoyang retired as the Chancellor of National Intelligence University and was a former Associate Provost at the Naval Postgraduate School. He has served in the Office of Science and Technology Policy in the White House, the Chief Training Officer for the FAA, and the Director of Training forNASA. He was awarded the Presidential Rank of Meritorious Executive in 1993 after serving on the Vice President Gore's National...

  3. Keeleliste elulugude uurimisvõimalusi: Dagmar Normeti mitmekeelne lapsepõlv Eestis. Possibilities of Research on Linguistic Biographies: Dagmar Normet, a Multilingual Childhood in Estonia

    Directory of Open Access Journals (Sweden)

    Anna Verschik

    2012-04-01

    author’s personal shift from German to Estonian as a preferred language of communication. Jewish topics, although present in the narrative, are by no means dominant (i.e., the struggle between Yiddish and Hebrew, Jewish secularism and tradition, Jewish and non-Jewish world. The memoir differs radically from East-European Jewish memoirs (for instance, the series by Isaac Bashevis Singer in the sense that the outside world is not perceived as antagonistic and hostile to Jews in general and to the author in particular, and there is no identity conflict. As the narrative contains text in other languages (for instance, the author’s childhood poetry in German, and some extracts from her diary are provided with the explanation that the diary was initially in German, a problem of the original, translation and self-translation arises. A written memoir inevitably has to keep a potential reader in mind and long prose excerpts in German would be confusing to a modern Estonian reader. Yet in some places the author employs stylisation by introducing dates of diary entries in German, accompanied by the German name of Tallinn (Reval. We can never know for sure at which point the author switched to Estonian and whether this transition was abrupt or smooth. Thus, connections between the original language, the narrator’s goals, and self-translation poses a problem for interpretation because one cannot be sure in what language what events took place. Self-translation becomes especially significant in written linguistic biographies because written texts are more premeditated than oral ones.

  4. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib.

    Science.gov (United States)

    Bragagni, Marco; Mennini, Natascia; Maestrelli, Francesca; Cirri, Marzia; Mura, Paola

    2012-01-01

    Topical administration of celecoxib proved to be an effective mean of preventing skin cancer development and improving anticancer drugs effectiveness in skin tumors treatment. The aim of this study was the development of an effective topical formulation of celecoxib, able to promote drug skin delivery, providing its in depth penetration through the skin layers. Three kinds of vesicular formulations have been investigated as drug carriers: liposomes containing a surfactant, or transfersomes and ethosomes, containing suitable edge activators. Firstly, the effect of membrane composition variations on the system performance has been evaluated for each vesicle type. Selected formulations were characterized for particle size, polydispersity index and encapsulation efficiency. The best formulations were subjected to ex vivo permeation studies through excised human skin. All vesicular formulations markedly (p ethosomes, respectively. In particular, ethosomes containing Tween 20 as edge activator not only showed the best vesicle dimensions and homogeneity, and the highest encapsulation efficacy (54.4%), but also enabled the highest increase in drug penetration through the skin, probably due to the simultaneous presence in their composition of ethanol and Tween 20, both acting as permeation enhancers. Therefore, among the various vesicular formulations examined in the study, Tween 20-ethosomes can be considered the most promising one as carrier for topical celecoxib applications aimed to prevent skin cancer development and increase the anticancer drugs effectiveness against skin tumors. PMID:23043648

  5. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Denes [Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  6. Fabrication and Characterization of Sertaconazole Nitrate Microsponge as a Topical Drug Delivery System

    Science.gov (United States)

    Pande, V. V.; Kadnor, N. A.; Kadam, Rupali N.; Upadhye, S. A.

    2015-01-01

    Present study was taken up to develop a topical formulation that releases the drug in controlled manner, reduce the side effects associated with topical drug delivery and improve product efficacy with aid of microsponges. Microsponges loaded with sertaconazole nitrate were prepared by using quasi emulsion solvent diffusion with five different proportions of the polymer (Eudragit RS 100). The developed microsponges were analyzed for particle size, production yield, entrapment efficiency and drug content. Scanning electron microscopic images of microsponges revealed that they are spherical in shape and contain pores. Pore structure analysis was done by using mercury intrusion porosimetry technique, which confirmed the porous nature of microsponges. Microsponges were then incorporated in to a 1% corbopol gel and evaluated for pH, drug content, texture profile analysis and in vitro drug release. The batch F IV was found to be optimal as it shown 69.38% controlled drug release in 8 h that followed Higuchi model. PMID:26997694

  7. Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation.

    Science.gov (United States)

    El-Hadidy, Gladious Naguib; Ibrahim, Howida Kamal; Mohamed, Magdi Ibrahim; El-Milligi, Mohamed Farid

    2012-01-01

    This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers were incorporated, namely sodium deoxycholate or oleic acid. Drug-loaded MEs were evaluated for their physical appearance, pH, rheological properties and in vitro permeation studies using guinea pig skin. MEs based on polyoxyethylene(10)oleyl ether (Brij 97) as the surfactant showed pseudoplastic flow with thixotropic behavior and were loaded with voriconazole. Jojoba oil-based MEs successfully prolonged voriconazole release up to 4 h. No significant changes in physical or rheological properties were recorded on storage for 12 months at ambient conditions. The presence of permeation enhancers favored transdermal rather than dermal delivery. Sodium deoxycholate was more effective than oleic acid for enhancing the voriconazole permeation. Voriconazole-loaded MEs, with and without enhancers, showed significantly better antifungal activity against Candida albicans than voriconazole supersaturated solution. In conclusion, the studied ME formulae could be promising vehicles for topical delivery of voriconazole. PMID:21696340

  8. Functional Evaluation of Modified T Pouch as Ileal Neo bladder Ortho topic Reservoir

    International Nuclear Information System (INIS)

    We report on the functional results of ortho topic modified T pouch ileal neo bladder, incorporating serous- lined extra mural ileal anti reflux technique for urinary diversion after radical cystectomy. Material and Methods: From September 1998 through November 2001,42 patients of mean age 49 years (range 45-54) having invasive bladder carcinoma underwent radical cystectomy and ortho topic ileal neo bladder urinary diversion, the modified T pouch. Thirty-three patients were males while the remaining 9 were females. The mean follow up was 24 months (range 18-42). Preoperative unior bilateral ureteral dilatation was noted in 13/42 (30.9%) patients). Follow up included clinical examination, laboratory, radiological and uro dynamic investigations. Early postoperative complications were recorded in 3 cases, that were managed conservatively. Day and night continence were achieved in 34/42 (81 %) and 29/42 (69%) patients, night enuresis in 2 (4.8%),while satisfactory day and night continence were noted, respectively. Upper urinary tract (UUT) remained unchanged or improved in all cases. No need for clean intermittent catherization (CIC). No evidence of reflux was detected. Pressure at maximum capacity (average 17 cm H2O at 600 ml). Mean flow rate was 17.6 ml/sec (range 15-24). Pelvic cancer recurrence was recorded in 5 patients at mean 24 months, respectively. Modified T pouch has an excellent functional criteria as an ortho topic ileal neo bladder reservoir. It is absolutely indicated in short and/or massively dilated ureter

  9. Systemic absorption of topical steroids. Metabolic effects as an index of mild hypercortisolism.

    Science.gov (United States)

    Garden, J M; Freinkel, R K

    1986-09-01

    This study was undertaken to determine whether the commonly used treatment of psoriasis with potent topical glucocorticoids results in hypercortisolism and whether metabolic changes might provide a means for monitoring pharmacologic effects of excessive systemic absorption of glucocorticoids. Plasma cortisol, glucose, and insulin and circulating polymorphonuclear leukocytes were assessed under controlled conditions in five otherwise healthy patients with psoriasis (40% to 85% involvement) treated with topical desoximetasone, without occlusion. In all patients, there were rapid and sustained suppression of endogenous cortisol production, twofold to threefold increases in fasting insulin levels indicating insulin resistance, and elevated levels of polymorphonuclear leukocytes. Two patients also experienced reduced glucose tolerance. These findings suggest that application of potent corticosteroids to large areas of diseased skin results in sufficient systemic absorption to cause not only adrenal suppression but some degree of hypercortisolism with greater frequency and rapidity than has been suggested. Prospective monitoring of insulin-glucose relationships as a sensitive index of the metabolic effects of glucocorticoids may provide a means of assessing excess systemic absorption that is not predictable on the basis of adrenal suppression or circulating levels of the drug. Such prediction could have particular relevance in anticipating adverse clinical effects in the treatment of chronic skin disorders with potent topical glucocorticoids. PMID:3527074

  10. Biographies of Albert Einstein -- Mastermind of Theoretical Physics

    OpenAIRE

    Weinstein, Galina

    2012-01-01

    Over the years many have written biographies of Einstein. They all based their biographies on primary sources, archival material: memories and letters of people who were in contact with Einstein, Einstein's own recollections; interviews that Einstein had given over the years, and letters of Einstein to his friends - youth friends like Marcel Grossman and Michele Besso and later friends and colleagues like Heinrich Zangger; and especially his love letters with Mileva Mari\\'c. One can demarcate...

  11. Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic

    DEFF Research Database (Denmark)

    Brødsgaard, Anne; Nielsen, Tove; Mølgaard, Ulla; Pryds, Ole; Pedersen, Pernille

    2015-01-01

    healing times and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting. CONCLUSION: Treating umbilical granuloma with topical...

  12. Subtilisin-γ-glutamyl transpeptidase: a novel combination as ungual enhancer for prospective topical application.

    Science.gov (United States)

    Tiwary, Ekta; Gupta, Rani

    2010-12-01

    A feather degrading strain of Bacillus licheniformis ER-15 was isolated which also degraded α-keratin of hooves. A detailed analysis revealed that a novel monomeric γ-glutamyl transpeptidase (GGT(30)), a proteolytic product of heterodimeric 67 kDa γ-glutamyl transpeptidase (GGT(67)), assists subtilisin during its action on α keratin. An equimolar combination of subtilisin and GGT(30) was designated as KerN and was used as ungual enhancer for topical application. KerN was effective in releasing proteins from nail plate surface and 300 µg of enzyme could release 41 µg protein/mg of nail after 24 h treatment. Scanning electron micrograph (SEM) revealed loosening of nail matrix confirming the action of KerN on nail keratin. Drug permeation studies revealed permeation of clotrimazole through both enzymatically pretreated nail plates and also through nail plates in presence of KerN. Nearly 58% drug could be retained by nail plates after 24 h of 300 µg/mL KerN which further enhanced up to 97% by prolonging the enzyme application. The enzyme was found to be stable in presence of drug even after 72 h. Thus, KerN can be used as an additive in formulation of topical drug for onchomycosis. PMID:20572051

  13. Comparative Study between topical applications liposomally entrapped DNA repair enzymes and thymidine dinucleotide as radioprotectors

    International Nuclear Information System (INIS)

    The delivery of active agents to the skin by liposome carriers received great interest during the last three decades. This is based on their potential to enclose various types of biological materials and to deliver them to diverse cell types. Recent work suggests that liposomes as vehicles for topical drug delivery may be superior to conventional preparations. Also, topical application of DNA repair enzymes to irradiated skin increases the rate of repair of DNA potentially damaged cells. Moreover, thymidine dinucleotide is a new skin photo-protective agent against non-ionizing radiation through induction of DNA repair. Gamma irradiation can produce DNA damage in human skin. DNA mutations have an important role in the development of skin cancer and precancerous skin lesions. Albino rats were irradiated with Cobalt-60 gamma radiation with different doses (0.5, 1.5, 3 Gy), and were treated by either thymidine dinucleotide or liposomally entrapped DNA repair enzymes topically 24 hours before irradiation. Evaluation was done histopathologically by H and E stain. Computerized image analyzer using Masson's trichrome stain was also done. Gamma radiation produced epidermal thinning and dermal inflammatory cells together with collagen fragmentation and clumping in a dose-dependent manner. Comparing between both thymidine dinucleotide and liposomally entrapped DNA repair enzymes pretreated and irradiated rats. Low dose irradiation (0.5 Gy) together with previous drugs showed preservation of epidermis with no inflammatory cells and also it maintained the normal architecture of collagen bundles. However, they were ineffective with higher doses. In conclusion our results may suggest that the effects of gamma radiation on the skin at low dose could be minimized by the use of these drugs before exposure

  14. The scientometric biography of a leading scientist working on the field of bio-energy

    Energy Technology Data Exchange (ETDEWEB)

    Konur, Ozcan [Sirnak University Faculty of Engineering, Department of Mechanical Engineering (Turkey)], email: okonur@hotmail.com

    2011-07-01

    This paper presents a scientometric biography of a Turkish scientist, Prof. Dr. Ayhan Demirbas, who is a leading figure in the field of bio-energy. It describes the method and importance of doing such biographies and suggests that there are too few of them, this one being the first in this specific area. It provides insight into the individual, his work, his research and links in his field of studies and research. Prof. Dr. Demirbas has spent almost three decades in research, particularly in the field of bio-energy. He has researched and taught in the field of renewable energies including biodiesels, biofuels, biomass pyrolysis, liquefaction and gasification, biogas, bioalcohols, and biohydrogen. He has also studied a great variety of subjects, such as the development of pulp from plants, chemical and engineering thermodynamics, chemical and energy education, global climate change, drinking water and cereal analyses. He has published 454 articles as of 2011.

  15. Handbook preparation as a tool for self- directed learning process: A case study on endocrine topic

    Directory of Open Access Journals (Sweden)

    Lale CERRAH ÖZSEVGEÇ

    2010-12-01

    Full Text Available This study examines the effectiveness of handbook preparation as a method in the self-directed learning process of student teachers in teaching endocrine glands, and increasing their levels of knowledge. Thirty student teachers were selected from a biology department. A pencil and paper test and a clinical interview procedure were used to collect data. The test had two open-ended questions investigating the knowledge level of the sample about endocrine glands and the basic concepts of the subject. The interview was conducted to search the effectiveness of the handbook preparation process on self-directed learning of the student teachers. The results revealed that the student teachers had very limited knowledge and also had misconceptions related to the endocrine topic. The handbook preparation method was very helpful for the student teachers to overcome their misconceptions about the subject and to increase their knowledge level. It was suggested that handbook preparation may be helpful for teaching other biology topics as a self-directed learning tool. However, it should be considered that the student teachers had heterogeneity with respect to skills.

  16. Learning about Teaching the Extracurricular Topic of Nanotechnology as a Vehicle for Achieving a Sustainable Change in Science Education

    Science.gov (United States)

    Blonder, Ron; Mamlok-Naaman, Rachel

    2016-01-01

    This study focused on teachers' transfer of a variety of teaching methods from a teaching module on nanotechnology, which is an example of a topic outside the science curriculum, to teaching topics that are part of the chemistry curriculum. Nanotechnology is outside the science curriculum, but it was used in this study as a means to carry out a…

  17. Musicians’ profession-related health issues and their evolving transformative learning through biography

    OpenAIRE

    Smilde, Rineke

    2009-01-01

    Within a study on ‘musicians as lifelong learners’, explorative biographical research was used. When analysing the learning biographies informed by grounded theory, the emergence of profession-related health issues was striking. More than half of the portrayed musicians suffered from both physical and psychological problems, the latter mostly consisting of performance anxiety (stage fright), which was often connected to low self-esteem. However creative coping strategies were also frequently ...

  18. Book review: The great rivalry: Gladstone and Disraeli: a dual biography

    OpenAIRE

    Berry, Richard

    2013-01-01

    "The Great Rivalry: Gladstone and Disraeli: A Dual Biography." Dick Leonard. IB Tauris. June 2013. --- Benjamin Disraeli and William Ewart Gladstone are without doubt the two most iconic figures of Victorian politics, whose distinctly different personalities and policies led to 28 years of bitter political rivalry. In The Great Rivalry, Dick Leonard aims to provide the full story of their rivalry and its origins, comparing the upbringing, education and personalities of the two leaders, as wel...

  19. Evaluation of Topical Preparations Containing Curcuma, Acacia and Lupinus Extracts as an Anti-inflammatory Drugs

    Directory of Open Access Journals (Sweden)

    M M Hamzah

    2011-06-01

    Full Text Available Summary: This work was suggested on the basis of presence of curcuminoids in curcuma and the presence of flavonoidal constituent in acacia and lupinus. The aim of this study was to study their possible anti-inflammatory effect by separately formulation of the three extracts in a suitable gel formula for topical administration and comparison of the prepared gels with a standard gel in the market (diclosal Emulgel by using the carrageenan induced paw edema model in albino rats. The extracts were subjected to phytochemical screening tests using reported methods to determine the presence of various phytoconstituents. Gel formulation was prepared containing 8% of each extract separately in gel base, namely sodium carboxy methyl cellulose (NaCMC. The pharmacological screening revealed that percent reduction of edema produced by curcuma extract was 30.0%, by acacia extract was 4%, by ethanol fraction lupinus was 18% and by chloroform fraction lupinus was 11.3%, while diclofenac sodium topical gel produced 48% reduction of edema. Industrial relevance: Medicinal plants provide a host of chemical compounds, which have been optimized on the basis of their biological activities. Chemical compounds present in medicinal plants have shown great promise in the management of various inflammatory disorders and have continued to serve as alternative and complementary therapies. The present study will help the industry to produce herbal drug effective in the treatment of inflammation with less side effect and less costly when compared to the synthetic drugs.

  20. Using a Process of Collective Biography Writing in Higher Education to Develop an Ability to Explore, Reveal and Critically Reflect

    Science.gov (United States)

    Wihlborg, Monne

    2013-01-01

    Teaching and learning are frequently treated as processes that are separate from each other, while teachers and learners are considered as disembodied entities with a neutral position towards the content which is negotiated. In collective biography writing (CBW), a very different approach is taken. Writing, reading and learning are seen as an…

  1. The Physicist and Astronomer Christoper Scheiner - Biography Letters, Works

    Science.gov (United States)

    Daxecker, Franz

    The Jesuit priest Christopher Scheiner was one of the most influential astronomers of the first half of the 17th century. He was a creative and down-to-earth natural scientist who worked in the fields of astronomy, physics, optics and ophthalmology, while following his vocations as university lecturer, church builder and pastor. In scientific matters he was Galilei's opponent. Their dispute centred on the priority of discovery in regard to the sunspots. Scheiner was not the first to discover the sunspots, but he gave the most detailed account thereofin his main work "Rosa Ursina sive Sol". He was, however, ceaseless in his defense of the geocentric system. In 1891, Anton v.Braunmühl published a biography of Father Scheiner. Ever since then, new documents have come to light, justifying the publication of a new biography. Among the documents now available is Scheiner's hitherto unknown dissertation. Notes taken during his lectures in Ingolstadt provide valuable information on astronomy using the telescope, an invention of his lifetime. His exchange of letters with personalities like Archduke Leopold V of Austria-Tyrol, with scientists like Magini, Galilei, Gassendi, Kepler and confriars Rader, Guldin, Alber, Minutuli, Cysat und Kircher is a source of precious insights. Letters to Scheiner from the Father Generals of his order display evidence of his superiors' zero tolerance for the helincentric system. They also disclose Scheiner's wish to become a missionary in China, the financial difficulties he faced while trying to find a publisher for his "Rosa Ursina sive Sol" and his personal shortcomings. A Scheiner obituary from 1650 was found in Cracow in 2001. It contains information on the troublesome last years of his life and has finally allowed us to determine the year of his birth. Scheiner's personality has been praised as well as criticized by many authors - sometimes depending on their ideological backgrounds. This holds true especially regarding the argument

  2. Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

    Science.gov (United States)

    Lim, Dae Gon; Kim, Ki Hyun; Kang, Eunah; Lim, Sun Hee; Ricci, Jeremy; Sung, Si Kwon; Kwon, Myoung Taek; Jeong, Seong Hoon

    2016-01-01

    The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z-average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue. PMID:27307736

  3. Polish-Jewish and Jewish-Polish Biographies: Repeated Reconnaissance

    Directory of Open Access Journals (Sweden)

    Agnieszka Czyżak

    2013-01-01

    Full Text Available The article contains reflections on changes in biographical writing, especially biography of persons of heterogenous ethnic identity. The biographies are not only reconstructions of an individual’s life, but also a clear testimony and reflection of changes in collective consciousness. It turns out that biographies also discover, in a peculiar way, the author’s identity, who, in the process of selection and creation of a biographical text, reveals a part of their own history. This aspect is clearly seen in texts by second and third generation Holocaust survivors, and is demonstrated by interpretations of Magdalena Tulli’s Włoskie szpilki [Italian High Heels] and Piotr Paziński’s Pensjonat [Boarding house].

  4. The Underdog Effect: The Marketing of Disadvantage and Determination through Brand Biography

    OpenAIRE

    Neeru Paharia; Anat Keinan; Jill Avery; Juliet B. Schor

    2011-01-01

    We introduce the concept of an underdog brand biography to describe an emerging trend in branding in which firms author a historical account of their humble origins, lack of resources, and determined struggle against the odds. We identify two essential dimensions of an underdog biography: external disadvantage, and passion and determination. We demonstrate that such a biography can increase purchase intentions, real choice, and brand loyalty. We argue that these biographies are effective beca...

  5. Adrenal insufficiency as a result of long-term misuse of topical corticosteroids.

    Science.gov (United States)

    Böckle, Barbara C; Jara, David; Nindl, Werner; Aberer, Werner; Sepp, Norbert T

    2014-01-01

    The treatment of chronic inflammatory skin disease is associated with the use of topical corticosteroids. Their efficacy, tolerability and adverse effects depend on several factors, specifically potency, type of preparation, extemporaneous dilutions, quantity used, magnitude of the treated body surface, frequency of application, location, patient age, method of application and condition of the skin barrier. We report on two men suffering from chronic inflammatory skin disease, who presented with fatigue and cushingoid appearance after prolonged self-application of potent corticosteroids. Impairment of the skin barrier due to their underlying skin disease, frequent self-application of topical steroids and repeated application of the entire body led to extensive absorption of these substances, eventually culminating in the suppression of the pituitary-hypothalamic-adrenal axis. In conclusion, topical corticosteroids are effective and well-established therapeutic modalities. However, inappropriate use of topical corticosteroids can cause side effects. PMID:24751677

  6. Vadim Kuznetsov. Informal Biography by Eyes of His First Adviser

    Directory of Open Access Journals (Sweden)

    Igor V. Komarov

    2007-06-01

    Full Text Available The paper is dedicated to the memory of prominent theoretical physicist and mathematician Dr. Vadim Kuznetsov who worked, in particular, in the fields of the nonlinear dynamics, separation of variables, integrability theory, special functions. It includes his short research biography, an account of the start of his research career and the list of publications.

  7. Hypatia's Sisters: Biographies of Women Scientists - Past and Present.

    Science.gov (United States)

    Schacher, Susan

    This booklet gives two- or three-page biographies of seventeen women scientists. They range in history from Agnodice (physician, 300 B.B.) to Jane Goodall (born 1934). In addition, brief sketches are given of twenty-three other women scientists. This anthology is intended to fill a need for curriculum materials and literature that provide positive…

  8. Experiences of Teaching the Heat Energy Topic in English as a Second Language

    Science.gov (United States)

    Halim, Lilia; Dahlan, Fathiyah; Treagust, David F.; Chandrasegaran, A. L.

    2012-01-01

    In view of the current debate in Malaysia about the teaching of science and mathematics in English, a qualitative study was undertaken involving a purposeful sampling of three non-physics teachers to ascertain how well equipped they were with the necessary pedagogical content knowledge relating to the teaching of the topic of "heat energy" in the…

  9. Reclaiming Race as a Topic of the U.S. Biology Textbook Curriculum

    Science.gov (United States)

    Donovan, Brian M.

    2015-01-01

    Even though human racial difference has been a longstanding topic of the school biology curriculum, there is little evidence that contemporary biology textbooks challenge stereotypical racial beliefs that are based in biological thinking. Rather, the modern biology curriculum may be a place where such beliefs about race are perpetuated…

  10. Topical pimecrolimus as a new optional treatment in cutaneous sarcoidosis of lichenoid type.

    Science.gov (United States)

    Tammaro, Antonella; Abruzzese, Claudia; Narcisi, Alessandra; Cortesi, Giorgia; Parisella, Francesca Romana; Di Russo, Pier Paolo; De Marco, Gabriella; Persechino, Severino

    2014-01-01

    We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens. PMID:24826355

  11. Topical Pimecrolimus as a New Optional Treatment in Cutaneous Sarcoidosis of Lichenoid Type

    Directory of Open Access Journals (Sweden)

    Antonella Tammaro

    2014-01-01

    Full Text Available We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens.

  12. Topical Pimecrolimus as a New Optional Treatment in Cutaneous Sarcoidosis of Lichenoid Type

    OpenAIRE

    Antonella Tammaro; Claudia Abruzzese; Alessandra Narcisi; Giorgia Cortesi; Francesca Romana Parisella; Pier Paolo Di Russo; Gabriella De Marco; Severino Persechino

    2014-01-01

    We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens.

  13. The Uncertainty Reducing Capabilities of Primary Care Physicians' Video Biographies for Choosing a New Doctor: Is a Video Worth More Than Two Hundred Words?

    Science.gov (United States)

    Perrault, Evan K; Silk, Kami J

    2016-12-01

    Choosing a primary care physician for the first time is an important decision, one that health care systems do not make particularly easy for prospective patients to make solely through the limited information provided on their websites. Without knowledge from others, a new patient is likely to have uncertainty about the physician he or she chooses. Three hundred and twenty participants completed an online experiment and were exposed to two biographies of different doctors with different media and either professional or personal information. Predictions generated by media richness theory revealed greater reductions in uncertainty for video biographies than traditional text biographies. Video biographies, and those containing personal information about the physician, were also related to higher levels of anticipated patient satisfaction and care quality. When asked to choose the physicians they would want to visit, participants overwhelmingly chose the physician with whom they perceived the greatest similarity to themselves, as well as the doctor who provided a video biography. Both theoretical and practical implications of this research are discussed. PMID:27054561

  14. Evaluation of Topical Preparations Containing Curcuma, Acacia and Lupinus Extracts as an Anti-inflammatory Drugs

    OpenAIRE

    M M Hamzah

    2011-01-01

    Summary: This work was suggested on the basis of presence of curcuminoids in curcuma and the presence of flavonoidal constituent in acacia and lupinus. The aim of this study was to study their possible anti-inflammatory effect by separately formulation of the three extracts in a suitable gel formula for topical administration and comparison of the prepared gels with a standard gel in the market (diclosal Emulgel) by using the carrageenan induced paw edema model in albino rats. The extracts we...

  15. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    Science.gov (United States)

    Volná, M.; Látal, F.; Kubínek, R.; Richterek, L.

    2014-01-01

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems.

  16. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    International Nuclear Information System (INIS)

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems. (paper)

  17. Fluorouracil Topical

    Science.gov (United States)

    ... topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [skin areas] caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat ...

  18. Testosterone Topical

    Science.gov (United States)

    ... in which the body does not produce enough natural testosterone). Testosterone is used only for men with ... topical may control your symptoms but will not cure your condition. Continue to use testosterone topical even ...

  19. Spaces, Trajectories, Maps: Towards a World-Systems Biography of Immanuel Wallerstein

    Directory of Open Access Journals (Sweden)

    Georgi Derluguian

    2015-08-01

    Full Text Available World-systems analysis, although itself a macrohistorical perspective, eminently allows for writing individual biographies because these are structurally conditioned and historically contingent trajectories developing in specific time and space. The biographical genre seems particularly useful in intellectual popularization and in exploring how macro-level concepts behave in observed empirical situations. This article offers and demonstrates specific recommendations and methodological warnings in application to the personal trajectory of Immanuel Wallerstein, the founder of world-systems analysis as an intellectual movement.

  20. Garcinia gardneriana (Planchon & Triana) Zappi. (Clusiaceae) as a topical anti-inflammatory alternative for cutaneous inflammation.

    Science.gov (United States)

    Otuki, Michel F; Bernardi, Camila A; Prudente, Arthur S; Laskoski, Kerly; Gomig, Franciane; Horinouchi, Cintia D S; Guimarães, Claudio L; Ferreira, Juliano; Delle-Monache, Franco; Cechinel-Filho, Valdir; Cabrini, Daniela A

    2011-07-01

    Garcinia gardneriana is popularly used in skin disorders; therefore, this article investigated the effect of G. gardneriana extracts from leaves, bark and seeds and two isolated compounds in ear oedema and leucocytes migration caused by croton oil. The topical application of the extract of G. gardneriana leaves was able to reduce (70 ± 3%, and ID(50) 0.33 mg/ear) ear oedema, while the seeds (51 ± 5%) and the wood (60 ± 12%) extracts were less effective. In a time-course evaluation, the leaf extract (1 mg/ear) was effective when applied 2 hr before and until 3 hr after the stimulation, presenting a higher effectiveness when applied right after croton oil (83 ± 7% inhibition). In addition, the leaf extract was able to diminish the myeloperoxidase (MPO) activity in 64 ± 13%, which suggests the inhibition of leucocyte infiltration that was confirmed by histological analysis. Also, both biflavonoids isolated from the leaves of G. gardneriana, fukugetin (or morelloflavone) and 13-naringenin-II 8-eriodictyol (GB-2a), were able to reduce ear oedema, with ID(50) values of 0.18 (0.10-0.28) and 0.22 (0.15-0.31) mg/ear, respectively, besides the inhibition of MPO activity of 52 ± 6% and 64 ± 5%, respectively. Using the fluorescent probe 2',7'-dichlorodihydrofluorescein diacetate, the leaf extract, fukugetin and GB-2a topically applied to the ear treated with croton oil reduced 52 ± 15%, 63 ± 17% and 83 ± 4%, respectively, the production of reactive oxygen species of the skin. Thus, these results reveal the anti-inflammatory effect of G. gardneriana leaves for topical usage, and both biflavonoids are responsible for this effect. PMID:21362142

  1. The State and Modernity as Anthropological Topics: A Very Short Introduction

    OpenAIRE

    Marina Simić

    2016-01-01

    This paper aims to offer a brief introduction to anthropological studies of modernity and the state. I try to introduce some of the most important theoretical works in this field, built up in different ethnographic contexts ranging from Turkey to Latin America. I was trying to show some of the possibilities of the research of modernity and the state in anthropology emphasizing what anthropology can offer to wider debates on these topics. I argue that the ideas of modernity and the state are f...

  2. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    International Nuclear Information System (INIS)

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation

  3. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, E.R.

    1986-06-01

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.

  4. The Concept of the Interculture in Time: (Intercultural Topics in Textbooks of French as a Foreign Language

    Directory of Open Access Journals (Sweden)

    Meta Lah

    2012-12-01

    Full Text Available The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that cover a fairly long period of time – among them the textbooks by two Slovenian authors: Južnič (1938 and Grad (1954, as well as some generally-used French textbooks, such as Cours de langue et de civilisation françaises (1953, Le nouveau sans frontières (1988 and Nouveau rond point (2011. The article is based on the hypothesis that high culture is more likely to be present in the older textbooks, which are based on traditional methods, whereas in modern textbooks more popular, everyday topics can be found. It is also presumed that topics in modern textbooks are, compared to their more traditional counterparts, introduced in an intercultural manner which could encourage students to compare the culture of the foreign country with their own. Both hypotheses are partly confirmed. In Slovenian textbooks there are very few culture-based topics. On the other hand, they are present in all French textbooks, regardless of the methodology. It is true that Mauger introduces more high culture than the others and that the intercultural topics are presented only in the most recent textbook. In all the others, it is exclusively the culture of the target country that is introduced.

  5. Comparison of intravenous and topical lidocaine as a suppressant of coughing after bronchoscopy during general anesthesia.

    Science.gov (United States)

    Jakobsen, C J; Ahlburg, P; Holdgård, H O; Olsen, K H; Thomsen, A

    1991-04-01

    Twenty-four consecutive patients scheduled for fiberbronchoscopy were randomized to receive double-blind either intravenous (1.5 mg/kg) or laryngotracheal (3 mg/kg) lidocaine to evaluate the influence on post-bronchoscopic laryngospasm, pain in the throat and coughing. Plasma lidocaine concentrations were analyzed 5, 15, 30 and 60 min after administration. None of the patients demonstrated laryngospasm or pain in the throat during the first hour after bronchoscopy. Patients receiving topical lidocaine coughed significantly more than patients receiving intravenous lidocaine, with a median number of coughs of 20 compared to 4, during the first hour (P less than 0.01). The plasma lidocaine concentrations were significantly higher after intravenous than after topical administration (P less than 0.001). After intravenous administration the plasma lidocaine concentrations exceeded the accepted level for potential toxicity in five out of 11 patients, but none of the patients developed toxic symptoms and no side-effects were observed. PMID:2038931

  6. Topic and Textual Coherence

    Institute of Scientific and Technical Information of China (English)

    何明烈; 戢焕奇

    2008-01-01

    Based on the investigation of the origin and definition of topic as well as the classification of textual coherence, this paper ana-lyzes the function of topic to non-coherence, imphcit coherence and explicit coherence, and concludes that topic relevance is the primary cri-terion for textual coherence.

  7. A Case Report: Red Skin Syndrome- as the Rebound Effect of Using a Long Term Potent Topical Corticosteroid

    Directory of Open Access Journals (Sweden)

    Cristine D. Octaviani

    2014-06-01

    Full Text Available 31 years old male suffered from a rare skin disorder, diagnosed of red skin syndrome. Seven years ago, symptoms was begun with a light itching on skin area of body as well as face, and visited a general practitioner, diagnosed of light allergic rhinitis. He was prescribed oral corticosteroid, methyl prednisolone 4 mg b.i.d and very potent topical corticosteroid, clobetasol. The symptoms was significantly disappeared and being rebound after stopping the prescription. To maintain this rebound effect, for seven years in on-off unhealed conditions, he used topical cream corticosteroid, clobetasol, that fully masked this worst rebound condition. When application of the topical cream was stopped, rebound effect relapsed and even red skin syndrome became worse than before. After 20 months of being fully stopped from corticosteroid, the symptoms finally slowly reduced. He almost fully recovered and had a normal life until now December 2013. By this case, we can learn that this red skin syndrome, resulted from side effect of corticosteroid, will be stopped by fully stopping administering orally or topically, and this will take quite long time for skin to recover.

  8. A biography of Peter Paul Hilbert: a history of someone who went out to see the Amazon

    OpenAIRE

    Klaus Hilbert

    2009-01-01

    This biography counts the story of my father, Peter Paul Hilbert (1914-1989), archaeologist of the Museu Paraense Emílio Goeldi, in Belém, Brazil, who, between 1948 and 1961, researched in the Middle Amazon. He wanted to tell stories about inhabitants who lived in the river banks and its cultures by developing an archaeology which privileged the relation between people, as well as between people and tropical environment.

  9. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  10. Participation of women as authors and editors in journals concerned with mental retardation and related topics.

    Science.gov (United States)

    Porter, Cari L; Christian, LeeAnn; Poling, Alan

    2003-02-01

    The present survey determined women's participation in eight journals concerned with mental retardation and related topics. The number of female authors was recorded for all articles published in these journals from 1991 through 2000. The number of women on the editorial board each year, for each journal, also was tabulated. For all years and all journals, women were first authors of 41% of articles published. Women wrote 34% of single-author articles. Overall, 45% of all authors were women. Women constituted 34% of the editorial board members for the eight journals combined. In sum, these data suggest that women's contribution to the mental retardation literature decreases with the prestige of the activity. PMID:12597719

  11. Misselling as a New Topic of Financial Education? A Didactic Analysis of Investment Advise after the Financial Crisis

    OpenAIRE

    Dirk Loerwald; Thomas Retzmann

    2010-01-01

    Personal financial investments are, as a matter of course, a topic of economic education because they are a life situation which is inherently economical. In contrast, faulty advising in banks which has become focussed upon due to the extent it has played a part in the recent financial crisis is mentioned neither in curricula nor in educational text books. Numerous private funds have been exposed as unprofitable investments. One reason for this problem is to be found in the marketing staff of...

  12. Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection

    Science.gov (United States)

    Bourne, Nigel; Stegall, Rachael; Montano, Raquel; Meador, Michael; Stanberry, Lawrence R.; Milligan, Gregg N.

    2005-01-01

    Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time. PMID:15728922

  13. Effect of a topical glucocorticoid, budesonide, on nasal mucosal blood flow as measured with 133Xe wash-out technique

    International Nuclear Information System (INIS)

    The ''vasoconstrictor'' effect of dermally applicated steroids is a widely used parameter when determining the potency of glucocorticoids. A similar effect on the nasal mucosa has been suggested as providing an explanation for the clinical effect of topically administered glucocorticoids in the treatment of nasal disorders such as allergic and vasomotor rhinitis. The recently described 133Xe wash-out method was used for the purpose of blood flow determination in 11 healthy subjects. In a randomized double-blind cross-over study, the effect of topically administered budesonide, a non-halogenated glucocorticoid, for 1 week was compared with that of placebo. No difference was found to occur in the mucosal blood flow after the administration of budesonide, as compared with placebo. It seems likely that a more complex activity than vasoconstriction is responsible for the clinical effect in the treatment of nasal disorders, and further research is required in order to clarify this issue. (author)

  14. Italiesin comme "expérience": une biographie intellectuelle de Christian Norberg-Schulz, de 1945 à 1963

    OpenAIRE

    Gjoesteen, Pauline

    2014-01-01

    The norwegian architect Christian Norberg-Schulz was among the first to publish an architectural theory after 1945: "Intentions in architecture" (1963). This dissertation proposes an intellectual biography in order to determine the aims and sources of the book, especially regarding the description of architectural space. This dissertation seeks to counter actual readings of the book by arguing for a definition of architectural research as a retroactive process between theory, history, critici...

  15. Inviting the other in: Porous thinking and dissolving borders in "Tropical spirit: biography of a jasmine garden"

    OpenAIRE

    Ismail, Yasser

    2011-01-01

    "Tropical Spirit: Biography of a Jasmine Garden" is a site-specific performance piece I developed as my final M.F.A Project. This paper outlines a chronology of the making of the piece in addition to presenting critical frameworks through which the project can be analyzed and situated in relation to contemporary aesthetics. I use critical frameworks borrowed from a variety of sources. Recent research done on borders by Performance Studies scholars Ramon Rivera-Servera and Harvey Young provide...

  16. Time and death in compiled adab "biographies"

    Directory of Open Access Journals (Sweden)

    Kilpatrick, Hilary

    2004-12-01

    Full Text Available In mediaeval Arabic belles-lettres (adab, accounts of lives are usually made up of quite short reports akhbār. These akhbār. are arranged in different ways, one of which is chronological order, but the compilers of such accounts apparently accord relative insignificance to chronological order. This paper examines some "biographies" compiled by al-Ṣūlī and Abū 1-Faraj al-Iṣbahānī, showing that temporal progression can exist in a "biographical" presentation, either alone or more often combined with other ways of organising the material. It then focuses on the placing of subjects' deaths in life accounts and on how they are integrated with the rest of the material. In conclusion, I suggest that when temporal progression is absent in "biographical" presentations, this should be seen as reflecting a mediaeval Arabic approach to life writing which differs from modem expectations but has its own rationale.

    En el género árabe medieval del adab (bellas letras, los relatos de vidas están normalmente compuestos a base de pequeñas noticias (ajbār. Estos ajbār están organizados de distintas maneras, una de las cuales es el orden cronológico, aunque los compiladores de tales noticias dan aparentemente poca importancia a tal orden. Este artículo estudia algunas «biografías» recogidas por al-Ṣūlī y Abū 1-Faraŷ al-Iṣbahānī, y muestra que la progresión temporal puede existir en las presentaciones «biográficas», sola o junto con otras formas de organizar el material. En él se analiza también el lugar que las muertes de los personajes ocupan en el relato de sus vidas, y cómo se integran en el resto del material. En conclusión, propongo que si la progresión temporal está ausente en las presentaciones «biográficas», ello se debe a la manera característica que la literatura árabe medieval tiene de enfocar los relatos de vida, que posee su propia lógica, aunque difiera

  17. Misselling as a New Topic of Financial Education? A Didactic Analysis of Investment Advise after the Financial Crisis

    Directory of Open Access Journals (Sweden)

    Dirk Loerwald

    2010-07-01

    Full Text Available Personal financial investments are, as a matter of course, a topic of economic education because they are a life situation which is inherently economical. In contrast, faulty advising in banks which has become focussed upon due to the extent it has played a part in the recent financial crisis is mentioned neither in curricula nor in educational text books. Numerous private funds have been exposed as unprofitable investments. One reason for this problem is to be found in the marketing staff of the banks who did not invest their customer’s funds securely enough – and the customers did not notice it. What conclusions can be drawn from this for general financial education after the financial crisis? The economic education has failed to address the topic of “faulty advising in banks” as well. On the basis of categorical economic didactics the following contribution will analyse whether one has an exemplary case here upon which students can win generalized, transferable insights. In this context, the topic of personal financial investments will be classified in an efficient manner and the risk of opportunism in advising situations will be analysed with the help of the positive principal-agent theory. The results of this analysis of informational asymmetries within financial markets give direction to the development and revision of curricula in the didactics of economic education. With the following article a sustainable theoretical fundament will be created to underscore the obligatory inclusion of this topic in curricula as well as its realisation for target groups in school text books.

  18. Lavender-thymol as a new topical aromatherapy preparation for episiotomy: A randomised clinical trial.

    Science.gov (United States)

    Marzouk, T; Barakat, R; Ragab, A; Badria, F; Badawy, A

    2015-01-01

    The objective of this study was to evaluate the effectiveness of topical lavender-thymol in promoting episiotomy healing. This placebo-controlled, single-blinded, randomised clinical trial involved 60 primiparous women. REEDA score was used to evaluate the outcome of the trial. On the 7th post-partum day, women in Placebo-treated group had worse Redness, Edema, Ecchymosis, Discharge and Approximation (REEDA) score of 3.93 ± 3.65 compared with those in Lavender-thymol-treated group (2.03 ± 1.7) with significant difference (P = 0.013). Visual analogue Scale (VAS) score for pain at episiotomy in Lavender-thymol-treated group was 3.5 ± 1.9, whereas in Placebo-treated group it was 2.1 ± 2.2 (p = 0.011) for dyschezia, 3.8 ± 1.7 and 2.8 ± 1.6 in Placebo- and Lavender-thymol-treated women, respectively (p = 0.023). At 7th post-partum week, dyspareunia was more severe in Placebo-treated group compared with that in Lavender-thymol-treated group (5.3 ± 2.7 vs 2.7 ± 1.5 and p aromatherapy using lavender-thymol was highly effective, suitable and safe for episiotomy wound care with little or no expected side effects compared with that using placebo. PMID:25384116

  19. Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry

    DEFF Research Database (Denmark)

    Ba-Ali, Shakoor; Sander, Birgit; Brøndsted, Adam Elias;

    2015-01-01

    short-term effect of the anti-glaucoma drugs on the pupillary light reflex and in particular on the PIPR10-30s. METHODS: In this randomized, double-masked, crossover trial, pupillometry was performed before and after topical administration of latanoprost, dorzolamide, and timolol in 20 healthy subjects...... red light PIPR0-10s (p = 0.02). Pupillary size decreased slightly with timolol (0.1 mm, p = 0.03) and dorzolamide (0.2 mm, p < 0.001), but not with latanoprost. Timolol also reduced the maximal contraction amplitude significantly during red light (p = 0.02). Intraocular pressure was significantly...... reduced by all three drugs after 3.5 h (p < 0.01), while it remained unchanged during the control day (p = 0.3). CONCLUSION: Anti-glaucoma medications did not interfere with the blue light elicited PIPR. Dorzolamide reduced pupil size, while timolol reduced both pupil size and maximal contraction to red...

  20. AI Topics

    OpenAIRE

    Buchanan, Bruce G; Glick, Jonathan

    2002-01-01

    The debut of the AI in the News column elsewhere in this issue of AI Magazine created a good opportunity to introduce the professional community to the AI Topics web site, home of the AI in the news virtual page. Although AI Topics is designed for the lay public, it serves a much larger audience.

  1. Werner Heisenberg. The language of the atoms. Life and work - a scientific biography - the ''joyous science'' (youth until Nobel price)

    International Nuclear Information System (INIS)

    With his discovery that measuring values of complementary fundamental quantities in the microscopic world cannot by arbitrarily precisely determined cutted Werner Heisenberg the Gordian knot for the finishing of quantum theory developed by Planck, Einstein, and others and opened by this a new ''golden era'' in the physics of the 20th century. On the base of the documents from his life and work, i. e. deeds, letters and reports of contemporaries, as well as the published and unpublished essays, books, and articles of Heisenberg - also the later on found, publications or manuscripts mainly coming from the inheritance - resulted this systematic biography of Heisenberg. The author, the last doctoral candidate of Heisenberg relied furthermore on factual and personal knowledges, mainly own remembrances on his doctoral father and his teachers, colleagues, and students. Because of the interest of an authentical biography of the theoretical physicist Heisenberg the presentation of the mathematical approaches and the corresponding derivations could not completely be abandoned. This biography appeals by this both to a scientifically cultivated as a wider in science interested audience and covers the first phase of Heisenberg's life until his Nobel price 1933.

  2. Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

    OpenAIRE

    Ramasamy Selvam; Ganapa Sureshbabu; Marimuthu Saravanakumar; D'Souza Prashanth

    2015-01-01

    The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India) as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, sw...

  3. Angiomatous reaction Kaposi-sarcoma-like as a side effect of topical corticosteroid therapy in lichen sclerosus of the penis.

    Science.gov (United States)

    Catricalà, Caterina; Marenda, Samantha; Muscardin, Luca Maria; Donati, Pietro; Lepri, Andrea; Eibenschutz, Laura

    2009-01-01

    Lichen sclerosus (LS) is a chronic inflammatory skin condition usually located in the anogenital area. Topical corticosteroid therapy is the first choice treatment which may arrest or delay the progression of the disorder. We report the case of a 74-year-old man presented with a 6-month history of nodular lesions localized on penis. The man had a previous history of genital lesions that had been diagnosed as LS and treated with long-term topical corticosteroid therapy. After 3 months of corticosteroid therapy, the patient observed the appearance of several nodular erythematous lesions on the penis with progressive disappearance of the clinical symptoms of LS. These purple to red asymptomatic angiomatoid nodules resembled the clinical features of Kaposi sarcoma. PMID:19580581

  4. Syntactic Topic Models

    CERN Document Server

    Boyd-Graber, Jordan

    2010-01-01

    The syntactic topic model (STM) is a Bayesian nonparametric model of language that discovers latent distributions of words (topics) that are both semantically and syntactically coherent. The STM models dependency parsed corpora where sentences are grouped into documents. It assumes that each word is drawn from a latent topic chosen by combining document-level features and the local syntactic context. Each document has a distribution over latent topics, as in topic models, which provides the semantic consistency. Each element in the dependency parse tree also has a distribution over the topics of its children, as in latent-state syntax models, which provides the syntactic consistency. These distributions are convolved so that the topic of each word is likely under both its document and syntactic context. We derive a fast posterior inference algorithm based on variational methods. We report qualitative and quantitative studies on both synthetic data and hand-parsed documents. We show that the STM is a more pred...

  5. A Summary of Information on the Behavior of the Yakima Fold Belt as a Structural Entity -- Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Winsor, Kelsey; Unwin, Stephen D.

    2012-08-01

    This document is one in a series of topical reports compiled by the Pacific Northwest National Laboratory to summarize technical information on selected topics important to the performance of a probabilistic seismic hazard analysis (PSHA) of the Hanford Site. The purpose of this report is to summarize available data and analyses relevant to the Yakima Fold Belt (YFB) that may bear on the question of whether or not the YFB behaves as a single seismotectonic province in which activity along one fold structure is representative of behavior along all other fold structures. This topic has met with a fairly high level of contention in the expert community and has the potential to result in significant impacts on an evaluation of seismic hazard at the Hanford Site. This report defines the relevant alternative conceptual models relevant to this technical issue and the arguments and data that support those models. It provides a brief description of the technical issue and principal uncertainties; a general overview on the nature of the technical issue, along with alternative conceptual models, supporting arguments and information, and uncertainties; and finally, it suggests some possible approaches for reducing uncertainties regarding this issue.

  6. An African (auto)biography: Ama Ata Aidoo's literary quest

    OpenAIRE

    Pujolràs i Noguer, Esther

    2011-01-01

    An African (Auto)biography: Ama Ata Aidoo's Literary Quest és un estudi exhaustiu del que considero que configura la primera fase de l'obra d'Ama Ata Aidoo, escriptora ghanesa. El text que marca la primera fase del desenvolupament i consolidació de la veu d'Aidoo és Our Sister Killjoy or Reflections from a Black-eyed Squint, un text inclassificable genèricament i una presència indiscutible en la literatura africana anglòfona. La tasca d'escriure que envolta a escriptors/es es defineix per un...

  7. Biografia coletiva, engajamento e memória: a miséria do mundo Collective biography, commitment and memory: the weight of the world

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Montagner

    2009-01-01

    Full Text Available Este trabalho procura relacionar a proposta de biografia coletiva de Pierre Bourdieu e suas possibilidades teóricas com a questão histórica do "engajamento" político dos cientistas, o que acaba por nos inserir no debate sobre o que é um intelectual, tema caro a muitos autores. Como exemplo polêmico, a forma elaborada desse engajamento por Pierre Bourdieu, em seu livro A miséria do mundo, é debatida neste artigo. Por fim, o interesse foi elaborar, à luz dessas ideias, uma proposta coerente de análise das trajetórias sociais e histórias de vida dos indivíduos inseridos em grupos comuns, assumindo como bases o conceito de memória coletiva de Halbwachs e de persona coletiva de Boltanski.This text aims to relate Pierre Bourdieu's proposal of collective biography and its theoretical possibilities to the historical question of the political 'commitment' of scientists, which pitches us once again into the debate on what is an intellectual, a key topic for many authors. As a polemical example, the article discusses the form in which this commitment is elaborated by Pierre Bourdieu in his book The weight of the world. It then seeks to develop these ideas into a coherent proposal for analyzing the social trajectories and life histories of individuals inserted in social groups, taking as its lead Halbwachs's concept of collective memory and Boltanski's notion of collective persona.

  8. Estradiol Topical

    Science.gov (United States)

    ... a medication that is applied topically to the vagina. Estradiol is in a class of medications called ... swelling, redness, burning, irritation, or itching of the vagina vaginal discharge Some side effects can be serious. ...

  9. Stephen Hawking and the universe a biography

    CERN Document Server

    Sztajnkrycer, Ben

    2012-01-01

    ABOUT THE BOOK Stephen William Hawking is arguably the most famous scientist since Albert Einstein. He is a theoretical physicist, applied mathematician, and cosmologist, but he is best known to non-scientists as the author of "A Brief History of Time," his best-selling book that unraveled the origins of the universe. His fame is so far-reaching that he has appeared on such popular entertainment as "Star Trek: The Next Generation" and "Late Night with Conan O'Brien." He has even been animated as a character on "The Simpsons." Hawking is also well known for being the longest-living survivor

  10. Explaining Today's Physics Through History and Biography

    Science.gov (United States)

    Lindley, David

    2014-03-01

    Quantum computers, string theory, holographic universes - to the general audience, today's physics can be as mystifying as it is fascinating. But modern ideas evolved from an earlier phase of physics - Newtonian mechanics, simple cause and effect - that is in principle easier for the non-expert to grasp. I have found that writing about physics from a historical and biographical perspective is an effective way to convey modern thinking by explaining where it comes from - it is a way of carrying the reader from concepts that make intuitive sense to ideas that seem, on first encounter, utterly bizarre. Smuggling explanations into stories satisfies the reader's desire for narrative - bearing in mind that narrative can include the evolution of ideas as well as tales about intriguing and original people.

  11. (Anti-)Biography and Neo-Impressionism

    OpenAIRE

    Foa, Michelle

    2012-01-01

    This article analyzes neo-impressionism in relation to the biographical model of art criticism and art history that became increasingly prevalent in France over the course of the 19th century. Examining the critical response to the neo-impressionists, as well as some of their pictures and writings, I argue for the centrality of questions of authorship, individuality, and subjectivity to the group and its reception. I identify a distinctly anti-biographical tendency in the movement, one that d...

  12. A Political Biography of Henry Fielding

    OpenAIRE

    Downie, Alan (J. A.)

    2009-01-01

    The most prominent writers of the eighteenth century, such as Swift and Defoe, Addison and Steele, Pope, Gay, Fielding and Johnson, were actively involved in writing pamphlets and periodical essays which were overtly political. Other writers well known in their own day whose literary reputations are beginning to rise once more – such as John Toland, Delarivier Manley and Eliza Haywood – were also heavily employed in the writing of political polemic. Situating the writings of the period ag...

  13. Efficacy of ACA strategies in biography-driven science teaching: an investigation

    Science.gov (United States)

    MacDonald, Grizelda L.; Miller, Stuart S.; Murry, Kevin; Herrera, Socorro; Spears, Jacqueline D.

    2013-12-01

    This study explored the biography-driven approach to teaching culturally and linguistically diverse students in science education. Biography-driven instruction (BDI) embraces student diversity by incorporating students' sociocultural, linguistic, cognitive, and academic dimensions of their biographies into the learning process (Herrera in Biography-driven culturally responsive teaching. Teachers College Press, New York, 2010). Strategies have been developed (Herrera, Kavimandan and Holmes in Crossing the vocabulary bridge: differentiated strategies for diverse secondary classrooms. Teachers College Press, New York, 2011) that provide teachers with instructional routines that facilitate BDI. Using systematic classroom observations we empirically demonstrate that these activate, connect, affirm, strategies are likely to be effective in increasing teachers' biography-driven practices. Implications for theory and practice are discussed.

  14. Abraham Pais Prize: Physics, History, and Biography

    Science.gov (United States)

    Cassidy, David C.

    2014-03-01

    Each of these fields differs in obvious and not so obvious ways from the others in terms of goals, methods, purposes, and perspectives. Yet each also holds much in common with the others. Having worked in these fields and crossed the boundaries between them, I will explore in this talk not only the similarities and differences I have encountered on this journey, but also my growing appreciation of how these fields together provide a unified perspective on physics as a science and a disciple and as a vital component of our broader human culture.

  15. A Biography for an Emerging Urban District

    DEFF Research Database (Denmark)

    Riesto, Svava

    2015-01-01

    spaces as important elements in the becoming of this site and as possibly valuable figures for its future development. The article contributes to the discussion about biographical perspectives on landscape and shows how bridging knowledge from the humanities and design disciplines can create new......Abandoned industrial sites are often the starting oint for urban redevelopment, forcing the involved actors to discuss which qualities are discrded, protected, and reused. By way of a case study of the ongoing redevelopment of the Carlsberg breweries in Copenhagen, the article emphasizes open...... perspectives on open spaces of industry....

  16. Mark Zuckerberg biography of an accidental billionaire

    CERN Document Server

    Melendez, Macie

    2012-01-01

    ABOUT THE BOOK Mark Zuckerberg is one of the world's youngest billionaires, thanks to his role in co-founding social networking site, Facebook. As Facebook has grown exponentially since its founding in 2004 (with 845 million monthly active users as of the end of December 2011 according to Facebook), Zuckerberg's popularity has also flown through the roof. Interesting on so many levels, Zuckerberg's quick rise to fame is one that the mass media and general public just can't get enough of. There's his Harvard education, his invention of one of the most popular Internet sites this world has ev

  17. Understanding Jung: recent biographies and scholarship.

    Science.gov (United States)

    Charet, F X

    2000-04-01

    The tendency to associate Jung with Freud has undergone a change and both are increasingly perceived as founders of depth psychological schools whose exact relationship is unclear. The separation of the two was largely due to Jung's rejection by the psychoanalytic community because of his perceived spiritual inclinations. Recent scholarship has emphasized these spiritual inclinations in both a positive and negative way and brought to light Jung's non-Freudian sources, while other Jungian practitioners are seeking a closer association with psychoanalysis. This conflicting development is related to tendencies in Jung himself that are evident in his own life and in research conducted into the writing and publication of Memories, Dreams, Reflections. Though the status of the latter as Jung's autobiography has been called into question there remains the necessity to explain the myth of Jung's life enshrined there and the impact this has had on a public looking for meaning in a time of considerable change. PMID:14533394

  18. Dictionary of World Biography: Second edition

    OpenAIRE

    Jones, Barry

    2015-01-01

    Jones, Barry Owen (1932- ). Australian politician, writer and lawyer, born in Geelong. Educated at Melbourne University, he was a public servant, high school teacher, television and radio performer, university lecturer and lawyer before serving as a Labor MP in the Victorian Parliament 1972-77 and the Australian House of Representatives 1977-98. He took a leading role in reviving the Australian film industry, abolishing the death penalty in Australia, and was the first politician to raise pub...

  19. (Anti-Biography and Neo-Impressionism

    Directory of Open Access Journals (Sweden)

    Foa, Michelle

    2012-07-01

    Full Text Available This article analyzes neo-impressionism in relation to the biographical model of art criticism and art history that became increasingly prevalent in France over the course of the 19th century. Examining the critical response to the neo-impressionists, as well as some of their pictures and writings, I argue for the centrality of questions of authorship, individuality, and subjectivity to the group and its reception. I identify a distinctly anti-biographical tendency in the movement, one that disquieted the critics and led them to try and re-inscribe biographical meaning back into the work of Georges Seurat. Indeed, though Seurat instituted a divide between his work and his life in a variety of ways, he also insisted throughout his career on his paternity over the neo-impressionist method. In all of these ways, the relationship between the self and art was a significant and problematic issue for the neo-impressionists and the critics around them.

  20. Davidson's Externalism and Swampman's Troublesome Biography

    Directory of Open Access Journals (Sweden)

    André Leclerc

    2005-12-01

    Full Text Available After the seminal works of Putnam (1975, Burge (1979, and Kripke (1982, the next important contribution to externalism is certainly Davidson’s (mainly 1987, 1988, 1989, 2001. By criticizing the posi-tions of these philosophers, Davidson elaborated his own brand of exter-nalism. We shall first present some features of Davidson’s externalism (the importance of historical-causal connections for the foundation of language and thought, for the explanation of how language can be learned, and how attitudes can be identified by the interpreter, and fi-nally how mental content is determined by appealing to the idea of trian-gulation, to prepare the discussion of a few problems. We then discuss two questions in Davidson’s externalism. First, how to reconcile the fact that external factors determine mental content, as Putnam, Burge and Davidson himself argued convincingly, with token-physicalism, the thesis that mental events are identical with physical events occurring “in the head” (or the thesis that mental events supervenes locally on brain ac-tivities? The second main problem is how to reconcile the first person authority with some prima facie consequences of externalism, mainly that we should know the relevant parts of our (natural and social envi-ronment in order to know the content of our own thoughts? We argue that Davidson’s answer to the first question is not successful, while his answer to the second was a breakthrough.

  1. High-Altitude Aggressions and Physiological Degeneration? The Biography of “Climate” as an Object of Scientific Inquiry in Colombia During the 19th and the Early 20th Centuries

    OpenAIRE

    Stefan Pohl-Valero

    2015-01-01

    Objective: to show the role played by experimental physiology in the way of understanding the effects of high-altitude climates on the functioning of the human body and the possibilities of progress of the Colombian nation throughout the 19th and early 20th centuries. Content: the transformation of the concept of climate as an object of scientific inquiry is explored over the studied period. This is done by analyzing investigations on respiratory capacity, nutrition and metabolism, blood chem...

  2. New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Mogensen, Stine; Treldal, Charlotte; Feldager, Erik;

    2012-01-01

    To evaluate the effect and acceptance of a new lidocaine lozenge compared with a lidocaine viscous oral solution as a pharyngeal anesthetic before upper gastrointestinal endoscopy (UGE), a diagnostic procedure commonly performed worldwide during which many patients experience severe discomfort...

  3. Spotlight Topics

    Science.gov (United States)

    A Spotlight Topic consists of a set of two or more review articles focused on a specific subject in surface science. The topics are recommended by the Board of Editors. A topic may be chosen because it is particularly new or fast-breaking, thus deserving introduction to the general readership. Or, it may be because a topic is especially controversial or confusing, requiring clarification by experts. Each review will give a critical assessment rather than an encyclopedic report. While our editors always will insist on fairness and accuracy, any review which forwards an opinion is bound to be somewhat subjective. Therefore, it is the editors' wish that the set of reviews written by different authors on the same subject matter will provide a broad and balanced viewpoint. It is often the case that an author who is an expert in a technique or method may be especially enthusiastic or critical about this technique or method. A companion review in the set may provide a different viewpoint. We are hopeful that the reader, after studying these reviews and checking some of the key references, will obtain an informed opinion of the subject. We think the set of reviews in a spotlight area will considerably shorten the ``learning time'' that a nonexpert would otherwise need to become knowledgeable about a subject. In this issue, we feature a spotlight topic on oxide surfaces. The set contains an overview article by Jacques Jupille, and four articles written by G. Pacchioni, F. Cosandey and T. E. Madey, B. G. Daniels, R. Lindsay and G. Thornton, and C. Noguera respectively. Of these, the article by Pacchioni has already appeared in SRL 7, 277 (2000). The other three articles appear in this issue. A reader who wishes to suggest a spotlight topic or recommend authors to write such reviews should contact the Editor-in-Chief. We would like to hear from you.

  4. High-Altitude Aggressions and Physiological Degeneration? The Biography of “Climate” as an Object of Scientific Inquiry in Colombia During the 19th and the Early 20th Centuries

    Directory of Open Access Journals (Sweden)

    Stefan Pohl-Valero

    2015-10-01

    Full Text Available Objective: to show the role played by experimental physiology in the way of understanding the effects of high-altitude climates on the functioning of the human body and the possibilities of progress of the Colombian nation throughout the 19th and early 20th centuries. Content: the transformation of the concept of climate as an object of scientific inquiry is explored over the studied period. This is done by analyzing investigations on respiratory capacity, nutrition and metabolism, blood chemistry and heart function in people of the eastern range of the Colombian Andes. Conclusions: beyond an institutional or disciplinary history of physiology, this article shows that some practices of experimental physiology played a role in the process of represent­ing the Colombian nation, territory, and population. The inhabitants of the Andean highlands were understood not only in terms of race and innate abilities, but also in terms of social classes and organic transformations. The idea that there was a supposed process of “physiological de­generation”, decreasing the efficiency of high-altitude workers, was tried to compensate through a “rational diet”.

  5. Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

    Directory of Open Access Journals (Sweden)

    Ramasamy Selvam

    2015-09-01

    Full Text Available The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, swelling of udder, consistency of milk, recovery period and product satisfaction score were assessed to evaluate the efficacy of Wisprec and reg; Spray. Topical application of Wisprec and reg; Advanced Spray have shown a significant improvement (p<0.001 in alleviation of rectal temperature, pain on palpation of udder and swelling of udder, and the consistency of milk was restored to normal after 3 to 4 days of treatment. The results demonstrate that the Wisprec and reg; Advanced spray could be considered as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs as a supportive therapy for clinical mastitis of dairy cows. [J Adv Vet Anim Res 2015; 2(3.000: 285-290

  6. A dry powder formulation from silk fibroin microspheres as a topical auto-gelling device.

    Science.gov (United States)

    Faragò, Silvio; Lucconi, Giulia; Perteghella, Sara; Vigani, Barbara; Tripodo, Giuseppe; Sorrenti, Milena; Catenacci, Laura; Boschi, Alessandra; Faustini, Massimo; Vigo, Daniele; Chlapanidas, Theodora; Marazzi, Mario; Torre, Maria Luisa

    2016-06-01

    With the aim of establishing the formulation of a new hydrophilic auto-gelling medical device for biomedical applications, fibroin-based microspheres were prepared. The proposed microspheres were produced by a cost-effective and industrially scalable technique, such as the spray-drying. Spray-dried silk fibroin microspheres were obtained and the effects of different hydrophilic polymer on the process yield, microsphere morphology and conformation transition of fibroin were evaluated. The final auto-gelling formulations were obtained by adding calcium gluconate (as a calcium source for alginate crosslinking) to the prepared microspheres and tested by an in vitro gelling test. This study showed that the combination of fibroin with sodium alginate and poloxamer produced the most promising auto-gelling formulation for specific biomedical applications, such as the treatment of pressure ulcers. PMID:25757645

  7. American National Identity in a Globalized World as a Topic in the Advanced EFL-Classroom

    Directory of Open Access Journals (Sweden)

    Peter Freese

    2008-06-01

    Full Text Available In order to make an issue as complex and controversial as that of ‘national identity’ teachable in the advanced EFL-classroom, it has to be reduced to exemplary aspects and illustrated with concrete examples. Therefore, I will suggest an appropriate ‘Course Opener,’ briefly survey the historical unfolding of the American identity concept in order to provide teachers with the necessary background knowledge, and then suggest two teaching units, the first of which traces some major developments by means of ‘classic’ texts, whereas the second deals with the crucial issue of whether a shared language is a prerequisite for a shared identity.

  8. New insights for an old topic: seagrasses as bioindicators of coastal trace element pollution

    OpenAIRE

    Richir, Jonathan; Lejeune, Pierre; Gobert, Sylvie

    2014-01-01

    The marine magnoliophyte Posidonia oceanica (L.) Delile has been widely used since the mid-70th to biomonitor the coastal pollution of the Mediterranean in Cr, Ni, Cu, Zn, Cd, Pb and/or Fe. In contrast, other trace elements (TEs) like As, V, Ag, Be, Al, Mn, Co, Se, Mo, Sn, Sb and Bi, many of them categorized as TEs of environmental emerging concern, have been subject to nearly no ecotoxicological survey with that species. It has been shown that the French Mediterranean littoral was submitted ...

  9. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2016-01-01

    The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constrainedness. More concretely, this means by hardening or softening the constraints at hand, resulting in a higher or lower level of constrainedness. Finally, we discuss how future studies can employ and inform these new concepts, which we see as potentially rich for cross-disciplinary creativity research...

  10. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2015-01-01

    The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constrainedness. More concretely, this means by hardening or softening the constraints at hand, resulting in a higher or lower level of constrainedness. Finally, we discuss how future studies can employ and inform these new concepts, which we see as potentially rich for cross-disciplinary creativity research...

  11. Modern nuclear medicine methods as a topic of biophysics in veterinary training at UVM in Kosice

    International Nuclear Information System (INIS)

    Diagnostic and therapeutic application of ionising radiation is very important in all of branches of medicine including veterinary medicine. In veterinary training at University of Veterinary Medicine in Kosice (UVM), biophysics is a basic subject and it grants physical basis necessary for understanding subsequent subjects such as veterinary surgery, roentgenology, orthopedics. In view of this, traditional methods of radiology such as fluoroscopy, skiagraphy and tomography are explaining. The appearance and application of the theory so called reconstruction of image and also computers led to qualitatively new solutions via the development of modern methods in radiology. Explaining of physical principles, advantages or disadvantages of these new methods is also important in veterinary training although some of them do not use in veterinary practice yet. Two modern methods of nuclear medicine using in diagnostic (SPECT and PET) are discussed bellow. (authors)

  12. Improved Materials for Use as Components in Kraft Black Liquor Recovery Boilers; TOPICAL

    International Nuclear Information System (INIS)

    This Cooperative Research and Development Agreement (CRADA) was undertaken to evaluate current and improved materials and materials processing conditions for use as components in kraft black liquor recovery boilers and other unit processes. The main areas addressed were: (1) Improved Black Liquor Nozzles, (2) Weld Overlay of Composite Floor Tubes, and (3) Materials for Lime Kilns. Iron aluminide was evaluated as an alternate material for the nozzles used to inject an aqueous solution known as black liquor into recovery boilers as well for the uncooled lining in the ports used for the nozzles. Although iron aluminide is known to have much better sulfidation resistance in gases than low alloy and stainless steels, it did not perform adequately in the environment where it came into contact with molten carbonate, sulfide and sulfate salts. Weld overlaying carbon steel tubes with a layer of stainless weld metal was a proposed method of extending the life of recovery boiler floor tubes that have experienced considerable fireside corrosion. After exposure under service conditions, sections of weld overlaid floor tubes were removed from a boiler floor and examined metallographically. Examination results indicated satisfactory performance of the tubes. Refractory-lined lime kilns are a critical component of the recovery process in kraft pulp mills, and the integrity of the lining is essential to the successful operation of the kiln. A modeling study was performed to determine the cause of, and possible solutions for, the repeated loss of the refractory lining from the cooled end of a particular kiln. The evaluation showed that the temperature, the brick shape and the coefficient of friction between the bricks were the most important parameters influencing the behavior of the refractory lining

  13. Formalin (0.25%) as topical anti-microbial agent in burns.

    OpenAIRE

    Nair R; Supe A; Samsi A

    1991-01-01

    In a prospective controlled trial, 0.25% formalin spray was compared with 2% silver sulfadiazine cream as the local treatment of burns. Formation and separation of eschar, infection and death rates were recorded. In the group receiving formalin, rates of formation and separation of eschar were significantly more (P less than 0.001 and P less than 0.05 resp.) compared to other group. Infection rate and fatality due to infection were also reduced. Other advantages of formalin are ...

  14. Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride

    OpenAIRE

    Rao Kovur; Najmuddin M; Satyanath B

    2008-01-01

    The present study was aimed for the development and evaluation of hydrotropic starch gels of terbinafine hydrochloride which is an allylamine derivative of antifungal agent was formulated by using corn starch and sodium salicylate as hydrotropic salt. The gels were prepared in presence and absence of propylene glycol. The prepared gels were evaluated for in vitro drug release, rheological behavior and microbial studies. The degree of increase in the drug diffusion was found to be in order c...

  15. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Directory of Open Access Journals (Sweden)

    Dal Mas J

    2016-09-01

    Full Text Available Juarana Dal Mas,1 Tailyn Zermiani,1 Liliani C Thiesen,1 Joana LM Silveira,2 Kathryn ABS da Silva,1 Márcia M de Souza,1 Angela Malheiros,1 Tania MB Bresolin,1 Ruth M Lucinda-Silva1 1NIQFAR, Graduate Program in Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Santa Catarina, Brazil; 2Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Paraná, Brazil Abstract: The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was -34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 µg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. Keywords: nanotechnology, nanoemulsion, Rapanea ferruginea, anti-inflammatory, phytomedicine

  16. Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

    Science.gov (United States)

    Nguyen, H. T. P.; Munnier, E.; Souce, M.; Perse, X.; David, S.; Bonnier, F.; Vial, F.; Yvergnaux, F.; Perrier, T.; Cohen-Jonathan, S.; Chourpa, I.

    2015-06-01

    The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ˜200 nm) and surface charge (zeta potential ˜ - 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ˜95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery.

  17. Same-sex families as a topic in the Nova Gorica kindergartens

    OpenAIRE

    Benko, Maja

    2013-01-01

    A family represents the beginning of someone's life. In the family a child acquires patterns, examples and directions for the future life. Families have their own sets of rules and functions which make the difference between them. As the families differ from each other, the same goes for individuals. The gender is one of the first divisions we face in our lives. It is assigned to us, although our opinion is not asked for. The gender is not a division between male and female. The social impact...

  18. Formalin (0.25% as topical anti-microbial agent in burns.

    Directory of Open Access Journals (Sweden)

    Nair R

    1991-01-01

    Full Text Available In a prospective controlled trial, 0.25% formalin spray was compared with 2% silver sulfadiazine cream as the local treatment of burns. Formation and separation of eschar, infection and death rates were recorded. In the group receiving formalin, rates of formation and separation of eschar were significantly more (P less than 0.001 and P less than 0.05 resp. compared to other group. Infection rate and fatality due to infection were also reduced. Other advantages of formalin are ease of application and the low east.

  19. TOPICAL REVIEW: Metallo-supramolecular modules as a paradigm for materials science

    Directory of Open Access Journals (Sweden)

    Dirk G Kurth

    2008-01-01

    Full Text Available Metal ion coordination in discrete or extended metallo-supramolecular assemblies offers ample opportunity to fabricate and study devices and materials that are equally important for fundamental research and new technologies. Metal ions embedded in a specific ligand field offer diverse thermodynamic, kinetic, chemical, physical and structural properties that make these systems promising candidates for active components in functional materials. A key challenge is to improve and develop methodologies for placing these active modules in suitable device architectures, such as thin films or mesophases. This review highlights recent developments in extended, polymeric metallo-supramolecular systems and discrete polyoxometalates with an emphasis on materials science.

  20. Topical report on sources and systems for aquatic plant biomass as an energy resource

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, J.C.; Ryther, J.H.; Waaland, R.; Wilson, E.H.

    1977-10-21

    Background information is documented on the mass cultivation of aquatic plants and systems design that is available from the literature and through consultation with active research scientists and engineers. The biology of microalgae, macroalgae, and aquatic angiosperms is discussed in terms of morphology, life history, mode of existence, and ecological significance, as they relate to cultivation. The requirements for growth of these plants, which are outlined in the test, suggest that productivity rates are dependent primarily on the availability of light and nutrients. It is concluded that the systems should be run with an excess of nutrients and with light as the limiting factor. A historical review of the mass cultivation of aquatic plants describes the techniques used in commercial large-scale operations throughout the world and recent small-scale research efforts. This review presents information on the biomass yields that have been attained to date in various geographical locations with different plant species and culture conditions, emphasizing the contrast between high yields in small-scale operations and lower yields in large-scale operations.

  1. Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride

    Directory of Open Access Journals (Sweden)

    Rao Kovur

    2008-01-01

    Full Text Available The present study was aimed for the development and evaluation of hydrotropic starch gels of terbinafine hydrochloride which is an allylamine derivative of antifungal agent was formulated by using corn starch and sodium salicylate as hydrotropic salt. The gels were prepared in presence and absence of propylene glycol. The prepared gels were evaluated for in vitro drug release, rheological behavior and microbial studies. The degree of increase in the drug diffusion was found to be in order corn starch gel with propylene glycol was greater than corn starch gel without propylene glycol. The microbial studies were carried out in soya bean casein digest medium with Candida albicans as test organisms and were found to be 22.86 ± 0.58 and 20.22 ± 0.65 mm for TCSG (IV and TCS (III, respectively. All the gels exhibited shear thinning. The rheogram indicated that the gel systems are pseudoplastic and exhibited thixotropy. The added propylene glycol has not appreciably altered the apparent viscosity values.

  2. Ciclopirox Topical

    Science.gov (United States)

    ... Use the applicator brush attached to the bottle cap to apply ciclopirox topical solution evenly to all affected nails. Also apply the ... the bottle cap and neck and replace the cap tightly on the bottle. Let the solution dry for about 30 seconds before you put ...

  3. Smugglers masters as lobbying. Off scanner at the borders is a topic for politicians

    International Nuclear Information System (INIS)

    Smugglers, who make use of the Ukraine-Slovak border for their business, might be satisfied after last week. The Slovak government ordered the switching off of scanning equipment monitoring the movement of goods by train through the Matovce border line. The modern equipment was substituted by people, who aren't able to check freight cars as effectively as gadgets. Not only in Ukraine are they celebrating this success in corruption, who demanded the shut-off of the scanning equipment The bosses on the Slovak side are also rubbing their hands. As told to TREND by Margareta Grecova, spokeswoman for Cargo Slovakia, 90% of goods that cross through the border at Matovce are unloaded. The most frequently transported commodities are ore, coal, chemical and petroleum products. Smugglers put their consignments among iron ore and coal. They prefer goods with high consumer taxes. Besides alcohol, there are mainly cigarettes. These are put into boxes which are concealed in various parts of the train. Favorite places are on the cars, approximately 15 centimeters underneath loaded ore and coal. Contraband may leave the train anywhere during a journey, most probably with Slovak help. A Ukrainian accomplice provides an alert where to find the smuggled cigarettes. A shadow of suspicion has fallen also on railway employees. If smuggled cigarettes are unloaded at train stations, along the track and at incidental stops, railway cooperation is highly probable. If nothing else they pretend not to see anything and ignore activities happening on a nearby train. This doesn't exclude the cooperation of employees in the firms where the cars unload. Or the customs officers, who receive alerts from Ukraine, and ignore certain parts of the train. It was the scanning devices which was helping to lessen corruption, each device making an archival recording of monitored cars. Moreover, it was proven that the devices could check trains incomparably better than people. Customs started using them for

  4. [Topical contraceptives].

    Science.gov (United States)

    Alipov, V I; Korkhov, V V

    1982-02-01

    Recently there has been little interest in topical contraceptives. The most popular are the cervical cap and the diaphragm. Other types of mechanical contraceptive devices are being investigated. Standley and Kessler have developed a device for introduction into the cervical canal with a reservoir of spermatocide, it does not block the flow of blood during menstruation. New models of vaginal rings are also being developed which are simple enough for self-insertion and also contain a reservoir of spermatocide. Work is being done on spermatocide-containing sponges in many countries. Another project being investigated is the possibility of using natural proteins, collagens, and other substances which absorb spermatozoids. The ancients used various vaginal suppositories to kill spermatozoids; in the late 19th century quinine sulfate was used for this, and a variety of substances have been used recently. These spermicidal creams also have the advantage of acting as anti-infectious agents in many cases. But they do have some negative effects. They are about 85% effective, are local irritants, and some cause discomfort during intercourse. And it is possible that some are resorbed by the body and act on the liver and other organs. Vaginal globules and suppositories are also popular. The "Kontraceptin-T" brand contains quinosol, boric acid, and tannin. There are also foaming tablets which are mixed with water and then introduced. New locally-active chemical substances are being developed in Japan, West Germany, and the USSR. Kontraceptin-E contains paranonyl-phenoxypolyethylene glycol and sodium dioctylsulfosuccinate. The "Norforks" and other preparations contain mercurial compounds which may turn out to be harmful. The future promises the development of products which will act to prevent fertilization by acting on the hyaluronidase and the acrosine of the spermatozoid, thus preventing it from penetrating the ovum. It would be best to find enzyme inhibitors which are

  5. Bicellar systems as new delivery strategy for topical application of flufenamic acid.

    Science.gov (United States)

    Rubio, L; Alonso, C; Rodríguez, G; Cócera, M; López-Iglesias, C; Coderch, L; De la Maza, A; Parra, J L; López, O

    2013-02-28

    In this work, bicellar systems, bilayered disc-shaped nanoaggregates formed in water by phospholipids, are proposed as a novel strategy for delivery of the anti-inflammatory flufenamic acid (FFA) to the skin. A comparative percutaneous penetration study of this drug in bicellar systems and other vehicles was conducted. The effects induced on the skin by the application of FFA in the different vehicles were analyzed by attenuated total reflectance-fourier transform infrared (ATR-FTIR). Additionally, using the microscopic technique freeze-substitution transmission electron microscopy (FSTEM) and X-ray scattering technique using synchrotron radiation (SAXS-SR), we studied the possible microstructural and organizational changes that were induced in the stratum corneum (SC) lipids and the collagen of the skin by the application of FFA bicellar systems. Bicellar systems exhibited a retarder effect on the percutaneous absorption of FFA with respect to the other vehicles without promoting disruption in the SC barrier function of the skin. Given that skin disruption is one of the main effects caused by inflammation, prevention of disruption and repair of the skin microstructure should be prioritized in anti-inflammatory formulations. PMID:23357252

  6. Development of backfill material as an engineered barrier in the waste package system. Interim topical report

    International Nuclear Information System (INIS)

    A backfill barrier, emplaced between the containerized waste and the host rock, can both protect the other engineered barriers and act as a primary barrier to the release of radionuclides from the waste package. Attributes that a backfill should provide in order to carry out its required function have been identified. Primary attributes are those that have a direct effect upon the release and transport of radionuclides from the waste package. Supportive attributes do not directly affect radionuclide release but are necessary to support the primary attributes. The primary attributes, in order of importance, are: minimize (retard or exclude) the migration of ground water between the host rock and the waste canister system; retard the migration of selected chemical species (corrosive species and radionuclides) in the ground water; control the Eh and pH of the ground water within the waste-package environment. The supportive attributes are: self-seal any cracks or discontinuities in the backfill or interfacing host geology; retain performance properties at all repository temperatures; retain peformance properties during and after receiving repository levels of gamma radiation; conduct heat from the canister system to the host geology; retain mechanical properties and provide resistance to applied mechanical forces; retain morphological stability and compatibility with structural barriers and with the host geology for required period of time. Screening and selection of candidate backfill materials has resulted in a preliminary list of materials for testing. Primary emphasis has been placed on sodium and calcium bentonites and zeolites used in conjunction with quartz sand or crushed host rock. Preliminary laboratory studies have concentrated on permeability, sorption, swelling pressure, and compaction properties of candidate backfill materials

  7. Development of backfill material as an engineered barrier in the waste package system- Interim topical report

    Energy Technology Data Exchange (ETDEWEB)

    Wheelwright, E.J.; Hodges, F.N.; Bray, L.A.; Westsik, J.H. Jr.; Lester, D.H.; Nakai, T.L.; Spaeth, M.E.; Stula, R.T.

    1981-09-01

    A backfill barrier, emplaced between the containerized waste and the host rock, can both protect the other engineered barriers and act as a primary barrier to the release of radionuclides from the waste package. Attributes that a backfill should provide in order to carry out its required function have been identified. Primary attributes are those that have a direct effect upon the release and transport of radionuclides from the waste package. Supportive attributes do not directly affect radionuclide release but are necessary to support the primary attributes. The primary attributes, in order of importance, are: minimize (retard or exclude) the migration of ground water between the host rock and the waste canister system; retard the migration of selected chemical species (corrosive species and radionuclides) in the ground water; control the Eh and pH of the ground water within the waste-package environment. The supportive attributes are: self-seal any cracks or discontinuities in the backfill or interfacing host geology; retain performance properties at all repository temperatures; retain peformance properties during and after receiving repository levels of gamma radiation; conduct heat from the canister system to the host geology; retain mechanical properties and provide resistance to applied mechanical forces; retain morphological stability and compatibility with structural barriers and with the host geology for required period of time. Screening and selection of candidate backfill materials has resulted in a preliminary list of materials for testing. Primary emphasis has been placed on sodium and calcium bentonites and zeolites used in conjunction with quartz sand or crushed host rock. Preliminary laboratory studies have concentrated on permeability, sorption, swelling pressure, and compaction properties of candidate backfill materials.

  8. Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment.

    Science.gov (United States)

    Cheng, Yung-Hsin; Tsai, Tung-Hu; Jhan, Yong-Yu; Chiu, Allen Wen-Hsiang; Tsai, Kun-Ling; Chien, Chian-Shiu; Chiou, Shih-Hwa; Liu, Catherine Jui-Lin

    2016-06-25

    Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment. PMID:27083831

  9. Nanoemulsion Therapy for Burn Wounds Is Effective as a Topical Antimicrobial Against Gram-Negative and Gram-Positive Bacteria.

    Science.gov (United States)

    Dolgachev, Vladislav A; Ciotti, Susan M; Eisma, Rone; Gracon, Stephen; Wilkinson, J Erby; Baker, James R; Hemmila, Mark R

    2016-01-01

    The aim of this study is to investigate the antimicrobial efficacy of two different nanoemulsion (NE) formulations against Gram-positive and Gram-negative bacteria in an in vivo rodent scald burn model. Male Sprague-Dawley rats were anesthetized and received a partial-thickness scald burn. Eight hours after burn injury, the wound was inoculated with 1 × 10(8) colony-forming units of Pseudomonas aeruginosa or Staphylococcus aureus. Treatment groups consisted of two different NE formulations (NB-201 and NB-402), NE vehicle, or saline. Topical application of the treatment was performed at 16 and 24 hours after burn injury. Animals were killed 32 hours after burn injury, and skin samples were obtained for quantitative wound culture and determination of dermal inflammation markers. In a separate set of experiments, burn wound progression was measured histologically after 72 hours of treatment. Both NE formulations (NB-201 and NB-402) significantly reduced burn wound infections with either P. aeruginosa or S. aureus and decreased median bacterial counts at least three logs when compared with animals with saline applications (p wound as measured by myeloperoxidase (MPO) assay and histopathology (p wound progression 72 hours after injury. Topically applied NB-201 and NB-402 are effective in decreasing Gram-positive and Gram-negative bacteria growth in burn wounds, reducing inflammation, and abrogating burn wound progression. PMID:26182074

  10. Exploring the Abyss. The Financial Crisis of 2008 ff. as a Central Topic of Problem-Centered Social Science Education

    Directory of Open Access Journals (Sweden)

    Thorsten Hippe

    2010-07-01

    Full Text Available The financial crisis of 2008 ff. and financial crises in general should be a central topic of social science education because these crises are a recurrent and therefore structural feature of modern capitalism which has severe consequences for citizens’ quality of life. Hence, the citizenry should know how to prevent such developments which endanger its well-being in a massive way. Therefore, learners should understand the relationship between the quality of people’s everyday lives and those economic institutions and political decisions which have led to the current mess. They should be enabled to critically evaluate the current misregulation of the financial sector and the economy in order to identify possible policy measures to prevent or at least to mitigate future crises. By educating (young citizens in this way, the (future general public can – as a necessary counterweight to the lobbyism of the finance industry – exert more prudent political pressure which gives politicians a greater incentive to regulate the financial sector and the economy in a manner which is beneficial for the vast majority of the people instead of for a small elite. Two core concepts of the social sciences can be used to make the roots of the seemingly complex topic more understandable for learners: liability and inequality.

  11. Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders

    Directory of Open Access Journals (Sweden)

    Serrano G

    2015-12-01

    Full Text Available Gabriel Serrano,1,* Patricia Almudéver,2,* Juan-Manuel Serrano,1 Javier Milara,2–5 Ana Torrens,1 Inmaculada Expósito,1 Julio Cortijo2–51Sesderma Laboratorios, 2Department of Pharmacology, Faculty of Medicine, University of Valencia, 3Clinical Research Unit, University General Hospital Consortium, 4CIBERES, Health Institute Carlos III, 5Research Foundation of the University General Hospital of Valencia, Valencia, Spain*These authors contributed equally to this workAbstract: Liposomes have been intensively investigated as carriers for different applications in dermatology and cosmetics. Ascorbic acid has potent antioxidant and anti-inflammatory properties preventing photodamage of keratinocytes; however, due to its instability and low skin penetration, an appropriate carrier is mandatory to obtain desirable efficacy. The present work investigates the ability of a specific ascorbate phosphatidylcholine (PC liposome to overcome the barrier of the stratum corneum and deliver the active agent into the dermis to prevent photodamage. Abdominal skin from ten patients was used. Penetration of PC liposomes was tested ex vivo in whole skin, epidermis, and dermis by means of fluorescein and sodium ascorbate. Histology and Franz diffusion cells were used to monitor the percutaneous absorption. Ultraviolet (UV-high performance liquid chromatography was used to analyze diffusion of sodium ascorbate through the different skin layers, while spectrofluorimetry and fluorescent microscopy were used for fluorescein monitoring. UVA/UVB irradiation of whole skin was applied to analyze the antioxidant capacity by Trolox assay and anti-inflammatory effects by tumor necrosis factor alpha and interleukin 1 beta enzyme-linked immunoassay. PC liposomal formulation improved skin penetration of fluorescein and ascorbate. Fluorescein PC liposomes showed better diffusion through epidermis than dermis while ascorbate liposomes showed better diffusion through the dermis than

  12. Novel aqueous chitosan-based dispersions as efficient drug delivery systems for topical use. Rheological, textural and release studies.

    Science.gov (United States)

    Lucero, M J; Ferris, C; Sánchez-Gutiérrez, C A; Jiménez-Castellanos, M R; de-Paz, M-V

    2016-10-20

    The use of a novel cross-linked thiolated chitosan (CTS) was investigated as the main component of aqueous dispersions (at 1% and 3% w/v) for topical drug delivery systems. The nonionic theophiline (Th) and the cationic diltiazem(.)HCl (Dt) (at 0.5% w/v concentration) were used as model drugs. All aqueous dispersions behaved as viscoelastic fluids. The CTS 1% dispersions showed predominance of viscous component and low viscosity. However, in the CTS 3% dispersions, both the elastic component and high viscosities prevailed. So, texture parameters improved from CTS 1% to 3% dispersions and CTS 3%-Dt showed greater cohesion and adhesion than CTS 3%-Th, but always below CTS alone. All dispersions showed a Fickian diffusion mechanism. Despite release profiles of both drugs almost fully overlapped at 1% CTS, diffusion coefficients confirmed Dt released faster than Th at 3% CTS. The rheological behavior and the chemical nature of the drugs explained these results. PMID:27474615

  13. Quignard et La Bruyère. La biographie en mode mineur

    Directory of Open Access Journals (Sweden)

    Anne-Marie Clément

    2010-12-01

    Full Text Available Dans Une gêne technique à l’égard des fragments. Essai sur Jean de La Bruyère, Pascal Quignard propose une biographie partielle et fragmentée de l’auteur des Caractères, entremêlée à une réflexion sur le fragment. En nous arrêtant aux options formelles retenues par Quignard (les enjeux de la coexistence du récit biographique et de l’essai réflexif, l’écriture fragmentaire et aux diverses postures de biographe-chroniqueur, d’essayiste ou d’écrivain d’un biographème imaginaire qu’il adopte, nous tenterons de saisir comment Une gêne technique, à travers la mise en œuvre d’une relation biographique singulière, donne à lire, en sous-texte des propos du biographe sur le biographé, ce que le biographé permet de révéler du biographe. In Une gêne technique à l’égard des fragments. Essai sur Jean de La Bruyère, Pascal Quignard offers a partial and fragmented biography of the author of Les Caractères that is intertwined with reflections on the literary fragment. In considering Quignard’s formal choices (the challenges involved in the coexistence of the biographical story and the reflexive essay, a form of fragmentary writing, as well as his various postures as biographer, essayist or author of an imaginary biographeme, we will attempt to elucidate the way in which Une gêne technique, through the implementation of a unique biographical relationship, presents a subtext to the remarks of the biographer on his subject that underscores what the biographee can reveal of the biographer.

  14. Selective neurophysiologic responses to music in instrumentalists with different listening biographies.

    Science.gov (United States)

    Margulis, Elizabeth Hellmuth; Mlsna, Lauren M; Uppunda, Ajith K; Parrish, Todd B; Wong, Patrick C M

    2009-01-01

    To appropriately adapt to constant sensory stimulation, neurons in the auditory system are tuned to various acoustic characteristics, such as center frequencies, frequency modulations, and their combinations, particularly those combinations that carry species-specific communicative functions. The present study asks whether such tunings extend beyond acoustic and communicative functions to auditory self-relevance and expertise. More specifically, we examined the role of the listening biography--an individual's long term experience with a particular type of auditory input--on perceptual-neural plasticity. Two groups of expert instrumentalists (violinists and flutists) listened to matched musical excerpts played on the two instruments (J.S. Bach Partitas for solo violin and flute) while their cerebral hemodynamic responses were measured using fMRI. Our experimental design allowed for a comprehensive investigation of the neurophysiology (cerebral hemodynamic responses as measured by fMRI) of auditory expertise (i.e., when violinists listened to violin music and when flutists listened to flute music) and nonexpertise (i.e., when subjects listened to music played on the other instrument). We found an extensive cerebral network of expertise, which implicates increased sensitivity to musical syntax (BA 44), timbre (auditory association cortex), and sound-motor interactions (precentral gyrus) when listening to music played on the instrument of expertise (the instrument for which subjects had a unique listening biography). These findings highlight auditory self-relevance and expertise as a mechanism of perceptual-neural plasticity, and implicate neural tuning that includes and extends beyond acoustic and communication-relevant structures. PMID:18072277

  15. A life of Erwin Schroedinger; Erwin Schroedinger. Eine Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Walter J.

    2012-07-01

    Erwin Schroedinger (1887-1961) was a pioneer of quantum physics, one of the most important scientists of the 20th century at all and - a charming Austrian. He was a man with a passionate interest in people and ideas. Mostly known he became by his representation of quantum theory in the form of wave mechanics, for which he got the Nobel prize for physics and naturally by the famous thought experiment ''Schroedinger's cat''. Walter Moore's biography is very close to the person of Schroedinger and presents his scientific work in the context of his private friendships, his interest in mysticism, and in front of the moving background of the political events in Germany and Austria.

  16. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct. The gr...

  17. ASSESSMENT OF EFFICACY OF TOPICAL PHENYTOIN SODIUM DRESSING AS COMPARED TO CONVENTIONAL MOIST DRESSING IN THE MANAGEMENT OF LEG ULCERS

    Directory of Open Access Journals (Sweden)

    Srikanth Reddy

    2015-10-01

    Full Text Available Chronic leg ulcers are one of the most common surgical conditions in surgical practice. From times immemorial, many methods have been tried to treat these types of ulcers. Many techniques have been tried over the centuries to aid in healing of chronic leg ulcers, but there exists no ideal dressing till date.(1 Phenytoin Sodium, a chemical used in management of Epilepsy, is known to produce gingival Hyperplasia, an indirect evidence to enhanced Fibroblastic activity. The present study was conducted to assess the efficacy of topical Phenytoin solution dressing as compared to conventional moist dressing in the healing process of chronic leg ulcers. Phenytoin Sodium being a cheap drug, is likely to cut down, the cost burden on the individual and the Society, if proven effective.

  18. An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis

    Directory of Open Access Journals (Sweden)

    Jaiswal Amit

    2007-01-01

    Full Text Available Background: Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and molds. Aims: To study the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in onychomycosis. Methods: A clinical comparative study was undertaken on 96 Patients of onychomycosis during the period between August 2005 to July 2006. Forty-eight patients were randomly assigned in group A to receive oral terbinafine 250 mg, one tablet twice daily for seven days every month (pulse therapy; 24 patients in group B to receive oral terbinafine pulse therapy plus topical ciclopirox olamine 8% to be applied once daily at night on all affected nails; and 24 patients in group C to receive oral terbinafine pulse therapy plus topical amorolfine hydrochloride 5% to be applied once weekly at night on all the affected nails. The treatment was continued for four months. The patients were evaluated at four weekly intervals till sixteen weeks and then at 24 and 36 weeks. Results: We observed clinical cure in 71.73, 82.60 and 73.91% patients in groups A, B and C, respectively; Mycological cure rates against dematophytes were 88.9, 88.9 and 85.7 in groups A, B and C, respectively. The yeast mycological cure rates were 66.7, 100 and 50 in groups A, B and C, respectively. In the case of nondermatophytes, the overall response was poor: one out of two cases (50% responded in group A, while one case each in group B and group C did not respond at all. Conclusion: Terbinafine pulse therapy is effective and safe alternative in treatment of onychomycosis due to dermatophytes; and combination therapy with topical ciclopirox or amorolfine do not show any significant difference in efficacy in comparison to monotherapy with oral terbinafine.

  19. Identity as a narrative of autobiography

    OpenAIRE

    Luba Jakubowska

    2010-01-01

    This article is a proposal of identity research through its process and narrative character. As a starting point I present a definition of identity understood as the whole life process of finding identification. Next I present my own model of auto/biography-narrative research inspired by hermeneutic and phenomenological traditions of thinking about experiencing reality. I treat auto/biography-narrative research as a means of exploratory conduct, based on the narrator’s biography data, also co...

  20. The Use of Holiday Biography in Generation-Based ‘Tourism Space’ Research

    OpenAIRE

    Kowalczyk-Anioł, Joanna

    2013-01-01

    The article presents the concept of generation-based ‘tourism space’ research using the holiday biography method. The author refers to her earlier research conducted among three generations of Łodź families. She discusses the biography method used in the research and approaches it from a geo-biographical point of view, showing possible ways of recording the phenomenon (the particular character of the source material collected) and the various options available at later stages of research - in...

  1. The Rapport Between Religious and Secular Academics in Russia: Two Episodes from the Biography of F. I. Uspenskiy

    Directory of Open Access Journals (Sweden)

    Pavel Ermilov

    2012-08-01

    Full Text Available The conflict between secular and religious academics is not the result of the many decades of enforced atheism but dates from a much earlier time. Two examples drawn from the academic biography of the noted Russian Byzantine studies expert may serve as an illustration of the difficult relations between representatives of the theological academies and of secular academics. The disputes regarded some points of scientific methodology. The author highlights the very seriously observed principle ofa competency guided approach to scientific studies. This was stressed to the point of this becoming an absolute principle. It continues even today to exert a negative resonance in the Russian academic world

  2. The Big Five, Self-Esteem, and Narcissism as Predictors of the Topics People Write About in Facebook Status Updates

    OpenAIRE

    Marshall, TC; Lefringhausen, K; Ferenczi, N

    2015-01-01

    Status updates are one of the most popular features of Facebook, but few studies have examined the traits and motives that influence the topics that people choose to update about. In this study, 555 Facebook users completed measures of the Big Five, self-esteem, narcissism, motives for using Facebook, and frequency of updating about a range of topics. Results revealed that extraverts more frequently updated about their social activities and everyday life, which was motivated by their use of F...

  3. Water-filtered infrared-A (wIRA) can act as a penetration enhancer for topically applied substances

    OpenAIRE

    Sterry, Wolfram; Ackermann, Hanns; Hoffmann, Gerd; Schanzer, Sabine; Meyer, Lars; Grone, Diego; Otberg, Nina; Lademann, Jürgen

    2008-01-01

    Background: Water-filtered infrared-A (wIRA) irradiation has been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by cortisone. Aim of the study: Investigation of the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised contr...

  4. An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine

    OpenAIRE

    Judd, Amy Maryanne

    2013-01-01

    The reduction of bacteria on the skin results in prophylactic and therapeutic benefits by reducing the occurrence of skin infections. Currently, chlorhexidine digluconate, a conventional topical antiseptic, permeates the skin poorly leaving viable opportunistic pathogens below the superficial layers of the stratum corneum. The aim of this study was to use polyamidoamine (PAMAM) dendrimers to enhance the topical delivery of chlorhexidine digluconate to improve its antimicrobial efficacy.

  5. The Genetic Principle as a Link between Everyday Knowledge and Politics - The Art-of-Teaching Workshop about the Topic "Future"

    OpenAIRE

    Andreas Petrik

    2004-01-01

    This article demonstrates, how didactics of social sciences can turn its focus from theoretical conceptions to the arrangement of learning processes. It simulates a best practice ("Lehrkunst") workshop (I.1.) which compares seven teaching units about the key topic "future" (I.2.). Two typical problems become concrete: exchangeable topics and the transfer to abstract categories. The genetic principle is introduced as a possible remedy: It combines categories with concepts and chooses special t...

  6. Water-filtered infrared-A (wIRA can act as a penetration enhancer for topically applied substances

    Directory of Open Access Journals (Sweden)

    Sterry, Wolfram

    2008-07-01

    increased penetration depth compared to the non-irradiated skin (mode A: The ratio of the amount of the dye in the deeper (second 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians and interquartile ranges for mode A of 0.017 (0.007/0.050, for mode B of 0.084 (0.021/0.106, for mode C of 0.104 (0.069/0.192 (difference between modes: p=0.0112, significant; comparison mode A with mode C: p<0.01, significant. In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation. Discussion: The better penetration of the hydrophilic dye fluorescein after or during skin irradiation (modes B and C can be explained by increased hydration of the stratum corneum by irradiation with wIRA. Conclusions: As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances – in the first case even of thermolabile substances – with a broad clinical relevance as a contact free alternative to an occlusive dressing.

  7. Serum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat.

    Science.gov (United States)

    Giagnoni, G; Marsi, A; Parolaro, D; Sala, M; Gori, E

    1976-12-01

    The application into the rat conjunctiva of various phlogistic agents, such as croton oil, mustard oil and formaldehyde, elicits an increase of serum corticosterone linearly related to the log of the applied concentrations, so that from their parallelized regression lines it is possible to calculate the phlogistic potency of each tested agent in reference to croton oil. The time kinetic of such an increase (elicited by croton oil) is compared with that of two other parameters previously adopted as indirect quantitative indices of the phlogosis: the adrenal ascorbic acid depletion and the liver tyrosine-alpha-ketoglutarate transaminase increase. Serum corticosterone is shown to be the quickest and the most sensitive of the adopted indices, even if the phlogistic potency of the tested agents and the precision of these evaluations substantially coincides whatsoever the index adopted. Finally the pathways of adrenocortical activation are investigated and it is shown that the activation may be peripherally blocked by topical application of corticosteroids (but not of local anesthetics) and centrally by hypophysectomy or parenteral administration of pentobarbital plus morphine. PMID:13751

  8. Preoperative subconjunctival injection of mitomycin C versus intraoperative topical application as an adjunctive treatment for surgical removal of primary pterygium

    Directory of Open Access Journals (Sweden)

    Ehab M Ghoneim

    2011-01-01

    Materials and Methods : Seventy eyes of 70 patients with primary pterygia were randomly allocated to two groups. The first group (Group A, 35 eyes received 0.1 ml of 0.15 mg/ml of subconjunctival MMC injected into the head of the pterygium 24 h before surgical excision with the bare sclera technique. The second group (Group B 35 eyes underwent surgical removal with the bare sclera technique with intraoperative application of MMC (0.15 mg/ml over bare sclera for 3 min. The study was performed between March 2007 and December 2008, and follow up was performed for 1 year postoperatively. Differences between frequencies in both groups were compared by the Chi-square test or Fisher exact test. Differences between means in both groups were compared by Student′s t-test. P 0.05. Postoperatively, scleral thinning occurred in one eye in each group that resolved by 5 months postoperatively. No serious postoperative complications occurred in either group. Conclusion : Preoperative local injection of 0.15 mg/ml MMC is as effective as intraoperative topical application of 0.15 mg/ml MMC for preventing pterygium recurrence after surgical removal.

  9. Nuclear energy - a topic of public opinion

    International Nuclear Information System (INIS)

    The establishment and extension of the communication process on the issue of nuclear energy are pointed out and the reasons for its development are analysed. Approaching the subject by writing a biography, the author followed the reporting on it in mass-media from 1974 to 1978. The contents of the reports are analysed. A long, latent phase was followed by a break-through caused by local protests at Wyhl. Then all those concerned tried to influence the opinion of the public in line with their intentions. Because of certain selective mechanisms one did not succeed in strengthening the tendency in favour of nuclear energy, on the contrary, the opposition increased to the point of open confrontation at Brokdorf and Grohnde. The late institutionalization of the topic by political parties etc. has reduced the necessity to take measures without making use of these official channels. Therefore, the time of big conflicts is said to be over. (HSCH)

  10. Non-occlusive topical exposure of human skin in vitro as model for cytotoxicity testing of irritant compounds.

    Science.gov (United States)

    Lönnqvist, Susanna; Briheim, Kristina; Kratz, Gunnar

    2016-02-01

    Testing of irritant compounds has traditionally been performed on animals and human volunteers. Animal testing should always be restricted and for skin irritancy mice and rabbits hold poor predictive value for irritant potential in humans. Irritant testing on human volunteers is restricted by the duration subjects can be exposed, and by the subjectivity of interpreting the visual signs of skin irritation. We propose an irritant testing system using viable human full thickness skin with the loss of cell viability in the exposed skin area as end point measurement. Skin was exposed to sodium dodecyl sulfate (SDS) at 20% concentration by non-occluded topical exposure to establish a positive control response and subsequent test compounds were statistically compared with the 20% SDS response. Cell viability and metabolism were measured with 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The model presents correlation between increased concentration of SDS and decreased viability of cells in the exposed skin area (R(2) = 0.76). We propose the model to be used for cytotoxicity testing of irritant compounds. With fully intact barrier function, the model comprises all cells present in the skin with quantifiable end point measurement. PMID:26446981

  11. Comparative study of the topical effectiveness of the Andiroba oil (Carapa guianensis) and DEET 50% as repellent for Aedes sp.

    Science.gov (United States)

    Miot, Hélio Amante; Batistella, Rafaelle Fernandes; Batista, Khristiani de Almeida; Volpato, Dimas Eduardo Carneiro; Augusto, Leonardo Silveira Teixeira; Madeira, Newton Goulart; Haddad, Vidal; Miot, Luciane Donida Bartoli

    2004-01-01

    DEET (N,N-diethyl-3-methylbenzamide) is nowadays the most effective mosquito repellent available, however, its use can present some topical and systemic side effects. Some botanical compositions, as Andiroba (Carapa guianensis), have been proved repellent properties at low cost and toxicity. An experimental study was driven involving four volunteers submitting their forearms covered with Andiroba oil at 100%, DEET 50%, refined soy oil, Andiroba oil 15% and in the absence of products, directly to healthy females of Aedes sp. The times of first and third bites were checked. The results showed that the median of the first bite without any product was 17.5s and the third bite, 40.0s. In the soy oil, the bites happened in 60.0s and 101.5s, in the presence of Andiroba oil 100%, in 56.0s and 142.5s and in Andiroba oil 15%, in 63.0s and 97.5s. The volunteers using DEET 50% had not received bites after 3600s in most of the experiments (p Andiroba oil compared to the soy oil, forearm without product and Andiroba oil 15%, showed discreet superiority (p Andiroba oil presents discreet repellent effect against bite of Aedes sp., being significantly inferior to DEET 50%. PMID:15517027

  12. The Role of Topical Brimonidine Tartrate Gel as a Novel Therapeutic Option for Persistent Facial Erythema Associated with Rosacea.

    Science.gov (United States)

    Johnson, Andrew William; Johnson, Sandra Marchese

    2015-09-01

    Rosacea is a chronic inflammatory skin condition that commonly presents with persistent facial erythema with or without the coincident presence of flushing, telangiectasias, inflammatory papules or pustules, phymatous changes, or ocular involvement. Patients often present with a constellation of various signs and symptoms of the disease, and an individualized treatment plan should be tailored to a patient's unique clinical presentation. Previously available medications for rosacea have all targeted the inflammatory erythematous papules and pustules frequently associated with the disease, leaving a therapeutic gap for the common manifestation of persistent facial erythema. Brimonidine tartrate 0.33% gel was approved by the US Food and Drug Administration in August 2013 as the first medication available for the topical treatment of persistent facial erythema associated with rosacea. Brimonidine gel is a highly selective α2-adrenergic receptor agonist with potent vasoconstrictive effects, which leads to significant reduction of persistent facial erythema in the majority of patients when applied once daily. Based on large-scale clinical trials and post-marketing reports, brimonidine gel has maintained a good safety profile with a minority of patients experiencing adverse effects from its use, most of which are cutaneous in nature, mild-to-moderate in degree, occur early after initiation of treatment, often resolve spontaneously with continued use, and generally resolve after discontinuation of use. Among the reported adverse effects, two distinct manifestations of worsened erythema have been described. Brimonidine gel can be integrated into a treatment regimen along with concomitant therapies for facial papules and pustules with no increased risk of adverse events with combination therapy. Education about optimal application methods, setting reasonable expectations for treatment, and minimizing inflammation are important factors for the successful use of brimonidine

  13. “A relic of an age still capable of a Romantic outlook”: Musical biography and The Master Musicians Series, 1899-1906

    OpenAIRE

    Wiley, C.

    2003-01-01

    Musical biography proliferated in England in the hagiographical climate of the later nineteenth century, partly as an outcome of the rise of the aesthetic of the idolised Great Composer and the corresponding emergence of musical canons (whose constituency was, however, by no means certain at this time). This article presents a theoretically-enriched demonstration of the paradigms through which its late Victorian authors attempted to canonise their subjects, focussing on three interrelated the...

  14. FOREWORD: Peter Clay Eklund: a scientific biography Peter Clay Eklund: a scientific biography

    Science.gov (United States)

    Cole, Milton W.; Crespi, Vincent H.; Dresselhaus, Gene F.; Dresselhaus, Mildred S.; Mahan, Gerald D.; Sofo, Jorge O.

    2010-08-01

    Peter Eklund grew up in Southern California and attended the University of California at Berkeley, majoring in physics. After working for one year at the Lockheed Missile and Space Company in Sunnyvale, California, he left to pursue graduate studies at Purdue University. There he carried out PhD research in strongly correlated electron and phonon systems under the supervision of J M Honig and L L van Zandt. Peter joined the group of Millie and Gene Dresselhaus at MIT in 1974 as a Postdoctoral Fellow after one year as an instructor at the University of Kentucky. At MIT, he continued work on strongly correlated systems in collaboration with Professor David Adler (who had an adjoining office), but for the most part he got excited about sp2 carbon systems and graphite intercalation compounds, a new research direction which the Dresselhaus group had started one year before Peter's arrival at MIT. Over the next 35 years Peter, Millie and Gene co-authored over 50 research articles, several review articles, and a big nine-hundred-and-fifty page book. In 1974, they saw graphite intercalation compounds as a long-neglected research direction of great promise. They studied these new materials together over the next 16 years, focusing on their optical spectroscopy. Their pioneering vibrational spectroscopy studies provided a means to characterize the fundamental properties of carbon materials. Optical spectroscopy became a centerpiece in the research portfolios of all three, both when they were together at MIT and after Peter left for the University of Kentucky in 1977 to start his independent career as an Assistant Professor of Physics. Peter became a full Professor at Kentucky in 1986. He continued to work with Millie and Gene and also acquired an ever-expanding network of students, postdocs and collaborators. As each new carbon nanostructure emerged—graphite intercalation compounds, fullerenes, carbon nanotubes, and most recently graphene—Peter was at the cutting edge

  15. Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides

    Science.gov (United States)

    Briz, Verónica; Sepúlveda-Crespo, Daniel; Diniz, Ana Rita; Borrego, Pedro; Rodes, Berta; de La Mata, Francisco Javier; Gómez, Rafael; Taveira, Nuno; Muñoz-Fernández, Mª Ángeles

    2015-08-01

    The development of topical microbicide formulations for vaginal delivery to prevent HIV-2 sexual transmission is urgently needed. Second- and third-generation polyanionic carbosilane dendrimers with a silicon atom core and 16 sulfonate (G2-S16), napthylsulfonate (G2-NS16) and sulphate (G3-Sh16) end-groups have shown potent and broad-spectrum anti-HIV-1 activity. However, their antiviral activity against HIV-2 and mode of action have not been probed. Cytotoxicity, anti-HIV-2, anti-sperm and antimicrobial activities of dendrimers were determined. Analysis of combined effects of triple combinations with tenofovir and raltegravir was performed by using CalcuSyn software. We also assessed the mode of antiviral action on the inhibition of HIV-2 infection through a panel of different in vitro antiviral assays: attachment, internalization in PBMCs, inactivation and cell-based fusion. Vaginal irritation and histological analysis in female BALB/c mice were evaluated. Our results suggest that G2-S16, G2-NS16 and G3-Sh16 exert anti-HIV-2 activity at an early stage of viral replication inactivating the virus, inhibiting cell-to-cell HIV-2 transmission, and blocking the binding of gp120 to CD4, and the HIV-2 entry. Triple combinations with tenofovir and raltegravir increased the anti-HIV-2 activity, consistent with synergistic interactions (CIwt: 0.33-0.66). No vaginal irritation was detected in BALB/c mice after two consecutive applications for 2 days with 3% G2-S16. Our results have clearly shown that G2-S16, G2-NS16 and G3-Sh16 have high potency against HIV-2 infection. The modes of action confirm their multifactorial and non-specific ability, suggesting that these dendrimers deserve further studies as potential candidate microbicides to prevent vaginal/rectal HIV-1/HIV-2 transmission in humans.

  16. Lytton Strachey : l’historien intime de deux reines Lytton Strachey’s Intimate Biographies of Two Queens

    Directory of Open Access Journals (Sweden)

    Jeannine Hayat

    2007-01-01

    Full Text Available The British writer Lytton Strachey (1880-1932 wrote biographies of the two most eminent Queens of England: Queen Victoria (1921 and Elizabeth and Essex (1928. The two books made him a very famous historian. However, he would personally have preferred to be admired for his poetry or his plays, for he was a very gifted literary author. Nevertheless many of Strachey’s readers have appreciated his conception of biography, as a means of personal confession while studying the destiny of a public figure. Indeed the Stracheyan way of life, free from Victorian moral standards and guided by the rules of the Bloomsbury group, inspired his story of Victoria and Elizabeth. Both Queens at the end of their lives and at the height of their power carried on strange love affairs: Victoria with her Scottish gillie and Elizabeth with the Earl of Essex, thirty years her younger. In fact, both romances subtly reflect Strachey’s own love affairs. He was himself engaged in a kind of common life with Dora Carrington— the painter, thirteen years younger than him, with whom he was not sexually involved— while he engaged in numerous homosexual love affairs.

  17. Listening comprehension for sentences: the accessibility of referents for pronouns as a function of age, topic continuity, and pronoun emphasis.

    Science.gov (United States)

    Kertoy, M K

    1991-12-01

    An auditory comprehension task was employed to determine how subjects (20 first graders, 20 fifth graders, and 20 adults) use topic continuity and contrastive emphasis in the assignment of referents for pronouns in sentences. Significant differences in performance for emphasized and unemphasized pronouns were found suggesting that subjects used contrastive emphasis when assigning referents for pronouns. Fifth graders overused the cue of topic continuity in assigning referents for emphasized pronouns. This effect has not been shown previously in studies of children's understanding of pronomial reference. An interaction between age and pronoun emphasis was also significant. This interaction suggests that developmental changes continued to take place in the learning of cues for resolving pronouns by school age children. PMID:1770333

  18. Concept mapping as a method to teach an evidence-based educated medical topic: a comparative study in medical students

    OpenAIRE

    Saeidifard, Farzane; Heidari, Kazem; Foroughi, Moein; Soltani, Akbar

    2014-01-01

    Background The objective of this study was to compare concept mapping with lecture-based method in teaching of evidence based educated topic to medical students. Methods This randomized controlled trial was carried out on medical students during sixth year of 7-year MD curriculum clerkship phase. Cluster randomization was used to divide students into intervention and control groups. Both groups, at the beginning, were taught “Diabetic Ketoacidosis” (DKA) using evidence-based tool named Critic...

  19. Mechlorethamine Topical

    Science.gov (United States)

    ... used to treat early stage mycosis fungoides-type cutaneous T-cell lymphoma (CTCL; a cancer of the ... as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this ...

  20. Representacion E Identidad: Content Analysis of Latina Biographies for Primary and Preadolescent Children Published 1955-2010

    Science.gov (United States)

    Lara, Margaret A.

    2012-01-01

    This study discusses the results of a content analysis of 75 Latina biographies for primary and pre-adolescent students that were published over a 16-year period, spanning from 1995 to 2010. Significant to this study was how Latinas were represented in the biographies and what changes can be seen over time. Using a rubric based on research by…

  1. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature is...... largely ignored by the critics. Thus, the article tests how topics may work in creative nonfiction. Two Danish bestsellers belonging to the genre, Frank’s Mit smukke genom ( My Beautiful Genome), about genomics, and Buk-Swienty’s Slagtebænk Dybbøl ( ‘Slaughter-bench Dybbøl’), a history book, are chosen as...... cases and analysed using a slightly modified motif model by Johansen. The result is that in both books the main topic is treated from a double perspective, but also that six out of seven secondary topics, or motifs, are treated as well. It is concluded that also in a topical sense creative nonfiction...

  2. Topics in Physical Mathematics

    CERN Document Server

    Marathe, Kishore

    2010-01-01

    This title adopts the view that physics is the primary driving force behind a number of developments in mathematics. Previously, science and mathematics were part of natural philosophy and many mathematical theories arose as a result of trying to understand natural phenomena. This situation changed at the beginning of last century as science and mathematics diverged. These two fields are collaborating once again; 'Topics in Mathematical Physics' takes the reader through this journey. The author discusses topics where the interaction of physical and mathematical theories has led to new points o

  3. Comparison of hyaluronic acid-containing topical eye drops with carbomer-based topical ocular gel as a tear replacement in canine keratoconjunctivitis sicca: A prospective study in twenty five dogs

    Directory of Open Access Journals (Sweden)

    David Williams

    2012-12-01

    Full Text Available The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS. Twenty five dogs with KCS treated with a topical carbomer (CA-based tear replacement gel were moved to treatment with a hyaluronic acid (HA-containing tear replacement eye drop. Dogs were subject to a full ophthalmic examination at the beginning of the study and after two and four weeks of treatment, Schirmer tear tests (STTs were performed at each examination. Conjunctival hyperemia, ocular discharge and ocular irritation were evaluated and scored on a 0-3 semi-quantitative scale. Values were compared before and after 4 weeks of treatment using a paired t-test. Evaluation scores were compared using the Wilcoxon signed rank test. The transfer from CA-based to HA-containing tear replacement significantly decreased the conjunctival hyperemia score from 2.12 ± 0.73 to 1.26 ± 0.59 and ocular discomfort was lowered from 2.11 ± 0.97 to 0.93 ± 0.75. Ocular discharge was reduced from a score of 1.04 ± 0.82 to 0.70 ± 0.53, however, the decrease did not reach statistical significance. Schirmer tear test was increased with statistical significance (p < 0.001 but given that the increase was only from 5.42 ± 3.50 to 6.19 ± 3.86 mm min-1; this was not considered clinically significant. This study demonstrated that HA-containing eye drops used twice daily in dogs with KCS had greater ameliorative effects on ocular surface health and discomfort than did CA-based topical gels used as or more frequently.

  4. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  5. Historical Topics in Algebra.

    Science.gov (United States)

    National Council of Teachers of Mathematics, Inc., Reston, VA.

    This is a reprint of the historical capsules dealing with algebra from the 31st Yearbook of NCTM,"Historical Topics for the Mathematics Classroom." Included are such themes as the change from a geometric to an algebraic solution of problems, the development of algebraic symbolism, the algebraic contributions of different countries, the origin and…

  6. A Preliminary, Open Label, Single-arm Study of Calcipotriene/Betamethasone Topical Suspension as a Supplement to Non-biologic Systemic Therapy for Psoriasis

    Science.gov (United States)

    Kupetsky, Erine; Houston, Neil A.M.

    2016-01-01

    Background: Calcipotriene/betamethasone topical suspension is a topical therapy that is often used as monotherapy as a first-line treatment for plaque psoriasis. The objective of this preliminary, open label, single arm study was to determine the efficacy of adding a topical suspension to a traditional systemic therapy for psoriasis, either methotrexate or acitretin. Methods: In this exploratory study, eight patients with chronic plaque psoriasis who were on stable methotrexate or acitretin treatment without clearance were treated with once-daily calcipotriene/betamethasone topical suspension. Subjects completed five study visits over 12 weeks. Primary outcome measure was improvement of two or more points in Investigator Global Assessment. Secondary endpoints included change in Body Surface Area, Dermatology Life Quality Index, and Patient’s Global Assessment from baseline to Week 12. Results: Overall, the median decrease in Investigator Global Assessment over 12 weeks was 1.5 points, with 50 percent of subjects experiencing a drop of two or more points in Investigator Global Assessment. All eight subjects had a reduction in Body Surface Area and Patient’s Global Assessment. There was a mean decrease in Dermatology Life Quality Index score of 78.9 percent, showing improved patient quality of life. In addition, all patients tolerated the treatment well and 6 of 8 patients had improved satisfaction level with their treatment by the end of the study. Conclusion: The topical suspension was effective and well-tolerated in conjunction with stable methotrexate or acitretin treatment in all eight patients in this study. These results support the feasibility of a larger scale study to further investigate the efficacy of these treatment combinations. The trial is registered at ClinicalTrials.gov, number NCT01761019. PMID:27462386

  7. Mexican and Mexican-American Literature for the Senior High School. Short Story, Novel, Biography.

    Science.gov (United States)

    San Jose Unified School District, CA.

    Lesson plans for Mexican and Mexican American short stories, novels, and biographies are contained in this curriculum guides designed to supplement traditional literature programs at the senior high school level. Four short stories are reproduced in full, with related lesson plans providing background information, vocabulary terms, reference…

  8. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 4.

    Science.gov (United States)

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the fourth volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  9. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 3.

    Science.gov (United States)

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the third volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  10. The Interplay between Teachers' Biography and Work Context: Effects on Teacher Socialization

    Science.gov (United States)

    Skerrett, Allison

    2010-01-01

    In this article, I use the process of self-reflection to examine how my biography influenced my teaching experiences in a particular school context. Drawing on these experiences and the work of scholars in this area, I contend that such self-knowledge is critical for teachers' successful socialization and retention in diverse schooling…

  11. Going to School with Madame Curie and Mr. Einstein: Gender Roles in Children's Science Biographies

    Science.gov (United States)

    Owens, Trevor

    2009-01-01

    One of the first places children encounter science and scientists is children's literature. Children's books about science and scientists have, however, received limited scholarly attention. By exploring the history of children's biographies of Marie Curie and Albert Einstein, the two most written about scientist in children's literature, this…

  12. A Short Biography of Paul A. M. Dirac and Historical Development of Dirac Delta Function

    Science.gov (United States)

    Debnath, Lokenath

    2013-01-01

    This paper deals with a short biography of Paul Dirac, his first celebrated work on quantum mechanics, his first formal systematic use of the Dirac delta function and his famous work on quantum electrodynamics and quantum statistics. Included are his first discovery of the Dirac relativistic wave equation, existence of positron and the intrinsic…

  13. "Working Lives": The Use of Auto/Biography in the Development of a Sociological Imagination

    Science.gov (United States)

    Stephenson, Carol; Stirling, John; Wray, David

    2015-01-01

    This article critically evaluates the attempt of the authors to develop a sociological imagination within first-year undergraduate students studying the discipline of sociology at a British university. Through a sociological analysis of biography and autobiography (of both teachers and students), we attempted to create a quality of mind that would…

  14. Lucretia Mott: Friend of Justice. With a Message from Rosalynn Carter. Picture-book Biography Series.

    Science.gov (United States)

    Sawyer, Kem Knapp

    An illustrated biography for children features Lucretia Mott, one of the pioneers of the movement for womens' rights. Born in 1793, Lucretia Mott was raised a Quaker; her strong spiritual beliefs underlay her outspoken advocacy of equal rights for women and blacks, and against war. Lucretia became a leader among those who wished to abolish…

  15. A Method for Understanding Their Method: Discovering Scientific Inquiry through Biographies of Famous Scientists

    Science.gov (United States)

    Fairweather, Elizabeth; Fairweather, Thomas

    2010-01-01

    Mendel and his peas. Goodall and her chimpanzees. Bentley and his snowflakes. Pasteur and his sheep. Not only do these stories intrigue students, but they also demonstrate the trials and tribulations associated with scientific inquiry. Using scientists' biographies piques student interest while providing an added dimension to their understanding…

  16. Biography Today: Profiles of People of Interest to Young Readers. Sports Series, Volume 8.

    Science.gov (United States)

    Abbey, Cherie D., Ed.

    This volume provides biographies on sports figures. Each entry offers at least one picture of the individual profiled, and bold-faced rubrics lead to information on birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences, hobbies, and honors and awards. Each entry ends with a list of…

  17. Biography Today: Profiles of People of Interest to Young Readers. Sports Series, Volume 7.

    Science.gov (United States)

    Abbey, Cherie D., Ed.

    This volume provides biographies on sports figures. Each entry offers at least one picture of the individual profiled, and bold-faced rubrics lead to information on birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences, hobbies, and honors and awards. Each entry ends with a list of…

  18. Spaces, Trajectories, Maps: Towards a World-Systems Biography of Immanuel Wallerstein

    OpenAIRE

    Georgi Derluguian

    2015-01-01

    World-systems analysis, although itself a macrohistorical perspective, eminently allows for writing individual biographies because these are structurally conditioned and historically contingent trajectories developing in specific time and space. The biographical genre seems particularly useful in intellectual popularization and in exploring how macro-level concepts behave in observed empirical situations. This article offers and demonstrates specific recommendations and methodological warning...

  19. Beyond Heroes and Role Models: Using Biographies to Develop Young Change Agents

    Science.gov (United States)

    Meyers, Laura E.; Holbrook, Teri; May, Laura A.

    2009-01-01

    Reading, writing, and discussing biographies provide unique opportunities for teachers and students. Critical thinking can be developed through questioning, predicting, and analyzing various biographical mediums--texts, photographs and illustrations, book reviews, websites, films, news articles, etc.--to learn more about an individual's life…

  20. Topical corticosteroid addiction and phobia

    OpenAIRE

    Aparajita Ghosh; Sujata Sengupta; Arijit Coondoo; Amlan Kusum Jana

    2014-01-01

    Corticosteroids, one of the most widely prescribed topical drugs, have been used for about six decades till date. However, rampant misuse and abuse down the years has given the drug a bad name. Topical steroid abuse may lead to two major problems which lie at the opposing ends of the psychosomatic spectrum. Topical steroid addiction, a phenomenon that came to be recognized about a decade after the introduction of the molecule is manifested as psychological distress and rebound phenomenon on s...

  1. Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation

    Directory of Open Access Journals (Sweden)

    Žugić Ana R.

    2015-01-01

    Full Text Available Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature. Nevertheless, there are no papers dealing with formulation of its isolates into topical preparations for treatment of skin infections. In present study, alkyl polyglucoside (APG - based vehicle was developed as carrier of U. barbata CO2-supercritical extract (U-SE that demonstrated the best antimicrobial potential in preliminary screening. For comparison, chosen extract in the same concentration and using the same procedure was incorporated into a pharmacopoeial vehicle. Comparative evaluation of physicochemical stability, efficiency and safety proved APG-based vehicle to possess certain preferential features as carrier of U-SE compared to the reference one, composing a topical formulation with potential clinical relevance in treatment of skin infections. [Projekat Ministarstva nauke Republike Srbije, br. III45017 i br. TR34031

  2. Differential Topic Models.

    Science.gov (United States)

    Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

    2015-02-01

    In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections. PMID:26353238

  3. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - Part 3: Mentha × piperita - Solanum dulcamara.

    Science.gov (United States)

    Calapai, Gioacchino; Minciullo, Paola L; Miroddi, Marco; Chinou, Ioanna; Gangemi, Sebastiano; Schmidt, Richard J

    2016-03-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph - now (since 2015)(†) called a European Union herbal monograph - has been produced. Part 3: Mentha × piperita L.-Solanum dulcamara L. PMID:26563681

  4. 从僧传与小说关系角度看《坛经》中的惠能传%A Study of Hui Neng's Biography in Rostrim Scriptures from the Perspective of Relation of Monks'Biographies and Fictions

    Institute of Scientific and Technical Information of China (English)

    王芳

    2015-01-01

    《坛经》的内容包括叙事性强的高僧惠能传记以及惠能佛学思想记录两大部分。在《坛经》版本演变的过程里,两大部分都有所变化,尤以惠能传记部分变化较为明显,且在变化中体现出其与世俗叙事文学与世俗文化心理的密切联系。可以将《坛经》惠能传记部分的文本置于更广阔的文化背景,从叙事学的视角出发,通过分析《坛经》惠能传记中谶言与神异情节的运用、人物形象的塑造等问题,管窥以惠能传记为代表的僧传文学与包括历史传记、小说在内的文化大背景的联系,印证中国古代文学与历史、虚构与真实难以割裂这一大文史观。%Rostrum Scriptures consists of two parts,biography of Hui Neng and the records of Hui Neng's thoughts.In the evolution progress of Rostrum Scriptures ,there were changes in both of the two parts,while discrepancies in the biography part are more obvious and related to earthly narra-tive literature as well as cultural mindset.This thesis puts Hui Neng's biography from Rostrum Scrip-tures into cultural background,analyzes the prophecies and character image from the perspective of narratology to glimpse the relation of monk biographies and cultural background including historic bi-ographies and fictions,and confirms that in ancient China,literature and history,fiction and reality cannot be totally split from each other.

  5. Physics 1922 - 1941 including presentation speeches and laureates' biographies

    CERN Document Server

    Zhou, Yong

    1965-01-01

    Physics presents Nobel Lectures on physics from the period of 1922 to 1941. This book is organized into 18 parts encompassing 36 chapters that cover various Nobel physics subjects. The first parts explore the advances in understanding the atom structure, experimental studies of electrons, X-ray spectra of the atomic structure, kinetic energy of free electrons, and discontinuous structure of matter. These topics are followed by discussions on the laws governing the thermionic phenomena, wave nature of electron, light molecular scattering, the development of quantum mechanics, properties of neut

  6. Physics 1942 - 1962 including presentation speeches and laureates' biographies

    CERN Document Server

    Zhou, Yong

    2013-01-01

    Physics 1942 - 1962 presents Nobel Lectures on physics from 1942 to 1962. This book is 20 chapters that cover various Nobel physics subjects. The opening chapters deal with the topics of molecular ray methods, exclusion principle, quantum mechanics, the ionosphere, development of the Meson theory, interaction between high-speed nucleons and atomic nuclei, and the artificial production of fast particles. Other chapters discuss the principle of nuclear induction, research in nuclear magnetism, the discovery of phase contrast, statistical interpretation of quantum mechanics, the hydrogen atom

  7. Linguistic Extensions of Topic Models

    Science.gov (United States)

    Boyd-Graber, Jordan

    2010-01-01

    Topic models like latent Dirichlet allocation (LDA) provide a framework for analyzing large datasets where observations are collected into groups. Although topic modeling has been fruitfully applied to problems social science, biology, and computer vision, it has been most widely used to model datasets where documents are modeled as exchangeable…

  8. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    Science.gov (United States)

    Harris, Reviewed By Harold H.

    1999-11-01

    until 1904, when he accepted a position that would not be considered a shrewd career move: Superintendent of Weights and Measures in Manila, Philippines! He was there only one year, but it was apparently a productive time, both in a minimally equipped laboratory and with the possible nascence of some of his ideas about bonding. In 1905, Lewis accepted a staff position at MIT, under A. A. Noyes, where he remained until 1912. At MIT, he continued his experimental work on thermodynamic systems and the development of modern thermodynamics, following the lead of J. W. Gibbs, whose work was being largely ignored by other chemists. As Noyes moved increasingly into administrative responsibilities, Lewis took over more and more of the supervision of scientific work in the laboratory. It was the capable job that he did for Noyes that led to his being offered a Professorship and Chair of the College of Chemistry at the University of California, Berkeley. The same spirit of adventure that took Lewis to Manila may be what led to his moving to scientifically backward California. In 1912, there was no serious science going on the Left Coast, and Berkeley was isolated from the nearest civilization (Chicago) by days of travel. Lewis initiated the expansion of great science westward, not only to Berkeley, but also to Caltech (in those days Throop Institute), UCLA, and Stanford. By dint of his contributions to thermodynamics and bonding theory (suggesting that electrons bond in pairs, long before there was quantum mechanical justification for such a strange idea), and his organizational and leadership talents, he turned the Berkeley Chemistry Department from a nonentity into one of the finest anywhere. Later in his career, he contributed to the understanding of the role of isotopes in chemistry and physics. This biography includes a useful listing of Lewis's 168 scientific publications. In an age when many renowned scientists have multiples of this number, it is perhaps good to be

  9. Academic Biography in the Context of the Anti-Formalist Campaign of the 1930s

    Directory of Open Access Journals (Sweden)

    Yelena N. Penskaya

    2014-07-01

    Full Text Available The paper is focused around two biographical themes. Theme one is history of demolishing Leningrad school of dramatic theory developed in the State Institute of History of Art (GIII in the 1920s. In 1931, the GIII was closed by a Sovnarkom resolution and transformed into Len- ingrad division of the State Academy of Art Studies (LOGAIS established by the same resolu- tion. Theme two is description of the ‘academic traumatism’, traumatic behavior and its bio- graphical effects caused by destruction of a whole scientific trend during the anti-formalism campaign of the early 1930s. Based on archival documents (from the Russian State Archive of Literature and Art, shorthand notes and reports on discussions of the 1930s, we analyze behav- ioral tactics of initiators, participants and victims of the longstanding stigmatization and catalog absolutory, denunciative and repentant narratives. In particular, this paper analyzes the un- published letter to the editors of Rabochiy i Teatr journal written by Alexander Slonimsky, one of the key players in development and obliteration of dramatic theory associated primarily with Alexei Gvozdev’s group and with transformation and dissolution of the leading humanities in- stitutes. The text of the letter appears to be engrained in the complicated mosaic of measures aimed to discredit Meyerhold’s theater practice and Gvozdev as the leader of the scientific school. Deliberate misinterpretation and corruption of self-descriptions along with reconstruc- tion of biographies are some of the most crucial factors that affected reception of cultural pro- jects and their creators in the 1930s and later.

  10. The theorist Guillermus de Podio: foundations for the construction of a biography.

    Directory of Open Access Journals (Sweden)

    Villanueva Serrano, Francesc

    2010-12-01

    Full Text Available Two works of music theory from the endings of the 15th Century with the name of author Guillermus de Podio are preserved: the printed Ars musicorum (València, Hagenbach and Hutz, 1495 and the manuscript Enchiridion de principiis musice discipline contra negantes illa et destruentes. Despite the great influence that this musician exerted on Spanish theorists of the 16th Century, there are only few commonly accepted data about his biography. This article pretends to offer solid foundations to build his biography. In first place, verified from speculated data in the historiography of the musician will be distinguished. Finally, new documents will clarify his identity and will reveal his work as master of chant in the catedral of Valencia.Bajo el nombre de autor de Guillermus de Podio se conservan dos obras de teoría musical de finales del siglo XV: la impresa Ars musicorum (Valencia, Hagenbach y Hutz, 1495 y el manuscrito Enchiridion de principiis musice discipline contra negantes illa et destruentes. A pesar de la gran influencia que este músico ejerció sobre los teóricos españoles del siglo XVI, son mínimos los datos biográficos generalmente aceptados por la comunidad investigadora. El presente artículo pretende ofrecer unos cimientos sólidos sobre los cuales poder construir su biografía. Con esta finalidad, se distinguen primeramente los datos contrastados de los que forman parte de la especulación en la historiografía del músico. Finalmente se aportan nuevos documentos que resuelven las dudas sobre su identidad y desvelan su magisterio en la catedral de Valencia. [ct] Sota el nom d’autor de Guillermus de Podio es conserven dues obres de teoria musical de finals del segle XV: l’impresa Ars musicorum (València, Hagenbach i Hutz, 1495 i el manuscrit Enchiridion de principiis musice discipline contra negantes illa et destruentes. Malgrat la gran influència que aquest músic va exercir sobre els teòrics espanyols del segle XVI

  11. Screening Jane. When History, Biography and Fiction create a Cinematic Life.

    Directory of Open Access Journals (Sweden)

    Roberta Grandi

    2015-07-01

    Full Text Available This paper analyzes the interesting technique of adaptation of the film Becoming Jane, a biopic on the life of Jane Austen, released in 2007. Loosely based on Jon Spence's biography Becoming Jane Austen, the film faces the problem of the scarcity of information on Jane Austen's life through a technique that, if not original nor always satisfying, is nevertheless worth being studied. By recurring to the character descriptions and the anecdotes narrated in the novels, the film (and Spence's book too "fills in the blanks" in Austen's life by adding touches of romance with questionable historical accuracy and fictionalizes the writer's biography in order to adapt it to the stereotype of modern romantic film heroines.

  12. Advancements in Topical Antifungal Vehicles.

    Science.gov (United States)

    Kircik, Leon H

    2016-02-01

    The primary treatment for superficial fungal infections is antifungal topical formulations, and allylamines and azoles represent the two major classes of topical formulations that are used to treat these infections. The stratum corneum (SC) is composed of keratinocytes that are surrounded by a matrix of lipids. The efficacy of topically applied formulations depends on their ability to penetrate this lipid matrix, and the vehicle plays an integral role in the penetration of active molecule into skin. There are several challenges to formulating topical drugs, which include the biotransformation of the active molecules as they pass through the SC and the physical changes that occur to the vehicle itself when it is applied to the skin. This article will review current and emerging topical antifungal vehicles. PMID:26885798

  13. Dr. William Gates, Dean, Graduate School of Business and Public Policy, Biography

    OpenAIRE

    2012-01-01

    Biography of Dr. William Gates, Dean, Graduate School of Business and Public Policy, Naval Postgraduate School, Monterey, CA. Dr. William (Bill) Gates, Associate Professor and Associate Dean of Research, was appointed the Dean of the Graduate School of Business and Public Policy (GSBPP) effective February 1, 2009. A graduate of Yale University (Ph.D.) and UC San Diego, Dr. Gates has been a professor of economics in GSBPP since 1988. Prior to joining NPS he was an economist at the Jet...

  14. Screening Jane. When History, Biography and Fiction create a Cinematic Life.

    OpenAIRE

    Roberta Grandi

    2015-01-01

    This paper analyzes the interesting technique of adaptation of the film Becoming Jane, a biopic on the life of Jane Austen, released in 2007. Loosely based on Jon Spence's biography Becoming Jane Austen, the film faces the problem of the scarcity of information on Jane Austen's life through a technique that, if not original nor always satisfying, is nevertheless worth being studied. By recurring to the character descriptions and the anecdotes narrated in the novels, the film (and Spence's boo...

  15. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B. [Massachusetts General Hospital, Harvard Medical School, Dept. of Dermatology, Boston, MA (United States); Cuevas, J. [Hospital Universitario de Guadalajara, Dept. of Pathology, Guadalajara (Spain); Villarrubia, V.G. [I.F. Cantabria SA, Medical Dept., Immunology Sect., Madrid (Spain)

    1997-12-31

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8{+-}0.59 times and MPD increased 2.75{+-}0.5 and 6.8{+-}1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au). 50 refs.

  16. Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dube syndrome: a double-blind placebo-controlled randomized split-face trial.

    Directory of Open Access Journals (Sweden)

    Lieke M C Gijezen

    Full Text Available BACKGROUND: Birt-Hogg-Dubé syndrome (BHD is a rare autosomal dominant disorder characterised by the occurrence of benign, mostly facial, skin tumours called fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax and an increased renal cancer risk. Current treatments for fibrofolliculomas have high rates of recurrence and carry a risk of complications. It would be desirable to have a treatment that could prevent fibrofolliculomas from growing. Animal models of BHD have previously shown deregulation of mammalian target of rapamycin (mTOR. Topical use of the mTOR inhibitor rapamycin is an effective treatment for the skin tumours (angiofibromas in tuberous sclerosis complex, which is also characterised by mTOR deregulation. In this study we aimed to determine if topical rapamycin is also an effective treatment for fibrofolliculomas in BHD. METHODS: We performed a double blinded, randomised, facial left-right controlled trial of topical rapamycin 0.1% versus placebo in 19 BHD patients. Trial duration was 6 months. The primary outcome was cosmetic improvement as measured by doctors and patients. Changes in fibrofolliculoma number and size were also measured, as was occurrence of side effects. RESULTS: No change in cosmetic status of fibrofolliculomas was reported in the majority of cases for the rapamycin treated (79% by doctors, 53% by patients as well as the placebo treated facial sides (both 74%. No significant differences between rapamycin and placebo treated facial halves were observed (p = 1.000 for doctors opinion, p = 0.344 for patients opinion. No significant difference in fibrofolliculoma number or change in size of the fibrofolliculomas was seen after 6 months. Side effects occurred more often after rapamycin treatment (68% of patients than after placebo (58% of patients; p = 0.625. A burning sensation, erythema, itching and dryness were most frequently reported. CONCLUSIONS: This study provides no evidence that

  17. Pantheon 1.0, a manually verified dataset of globally famous biographies.

    Science.gov (United States)

    Yu, Amy Zhao; Ronen, Shahar; Hu, Kevin; Lu, Tiffany; Hidalgo, César A

    2016-01-01

    We present the Pantheon 1.0 dataset: a manually verified dataset of individuals that have transcended linguistic, temporal, and geographic boundaries. The Pantheon 1.0 dataset includes the 11,341 biographies present in more than 25 languages in Wikipedia and is enriched with: (i) manually verified demographic information (place and date of birth, gender) (ii) a taxonomy of occupations classifying each biography at three levels of aggregation and (iii) two measures of global popularity including the number of languages in which a biography is present in Wikipedia (L), and the Historical Popularity Index (HPI) a metric that combines information on L, time since birth, and page-views (2008-2013). We compare the Pantheon 1.0 dataset to data from the 2003 book, Human Accomplishments, and also to external measures of accomplishment in individual games and sports: Tennis, Swimming, Car Racing, and Chess. In all of these cases we find that measures of popularity (L and HPI) correlate highly with individual accomplishment, suggesting that measures of global popularity proxy the historical impact of individuals. PMID:26731133

  18. Pantheon 1.0, a manually verified dataset of globally famous biographies

    Science.gov (United States)

    Yu, Amy Zhao; Ronen, Shahar; Hu, Kevin; Lu, Tiffany; Hidalgo, César A.

    2016-01-01

    We present the Pantheon 1.0 dataset: a manually verified dataset of individuals that have transcended linguistic, temporal, and geographic boundaries. The Pantheon 1.0 dataset includes the 11,341 biographies present in more than 25 languages in Wikipedia and is enriched with: (i) manually verified demographic information (place and date of birth, gender) (ii) a taxonomy of occupations classifying each biography at three levels of aggregation and (iii) two measures of global popularity including the number of languages in which a biography is present in Wikipedia (L), and the Historical Popularity Index (HPI) a metric that combines information on L, time since birth, and page-views (2008–2013). We compare the Pantheon 1.0 dataset to data from the 2003 book, Human Accomplishments, and also to external measures of accomplishment in individual games and sports: Tennis, Swimming, Car Racing, and Chess. In all of these cases we find that measures of popularity (L and HPI) correlate highly with individual accomplishment, suggesting that measures of global popularity proxy the historical impact of individuals. PMID:26731133

  19. SLN as a topical delivery system for Artemisia arborescens essential oil: In vitro antiviral activity and skin permeation study

    OpenAIRE

    Lai, Francesco; Sinico, Chiara; De Logu, Alessandro; Zaru, Marco; Müller, Rainer H.; Fadda, Anna M.

    2007-01-01

    The effect of SLN incorporation on transdermal delivery and in vitro antiherpetic activity of Artemisia arborescens essential oil was investigated. Two different SLN formulations were prepared using the hot – pressure homogenization technique, Compritol 888 ATO as lipid, and Poloxamer 188 and Miranol Ultra C32 as surfactants. Formulations were examined for their stability for two years by monitoring average size distribution and zeta potential values. The antiviral activity of free and SLN in...

  20. Topical Application of Vitreous Body as a New Alternative for the Treatment of Persistent Epithelial Defect and Dry Eye

    Directory of Open Access Journals (Sweden)

    Hamid Reza Jahadi Hosseini

    2010-10-01

    Full Text Available "nMany growth factors and chemical agents were previously used to accelerate corneal epithelial wound healing and dry eye .One of the enriched substances is autologous blood introduced with multiple randomized controlled studies for those who are not responsive to conventional treatments. Vitreous body as a natural substance has some properties which seem to make it superior to authologous blood for the management of severe dry eye syndrome and even persistent epithelial defect. This theory is based on some clues listed as below:"nVitreous contains a high amount of water and little macromolecules, the character suitable for a substance to be used for relieving symptoms of dry eye as a wetting effect. Moreover, it contains some growth factors such as insulin like growth factors and pigment epithelium-derived factor and high amount of viscous materials such as Chondroitin Sulfates and Hyaloronic acids, all are compounds seems to be effective in the management of dry eye and acceleration of epithelialization. It has also anti-inflammatory features. The most important unique feature of vitreous in comparison with blood is its immune privilege property documented by previous studies. Vitreous can be obtained from brain dead patients and also from eye banks easily.  As with all transplanted material of human origin, it carries risks of prion transmission; however, for intractable severe dry eye, benefits may greatly exceed the risk.

  1. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Bahrami A

    2008-04-01

    Full Text Available ANGIPARSTM is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARSTM and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities."nTwenty one patients with diabetic foot ulcers were divided into 3 groups. The first group received 100 mg of oral ANGIPARSTM twice a day for 6 weeks in addition to conventional therapies. In the second group, ANGIPARSTM gel 3% was added to the oral form of the same product besides the conventional therapies for the same period of time. Finally, in the third group which was considered as control, only conventional therapies were performed. The patients were followed for 6 weeks. Parameters such as granulation tissue formation, skin epithelization, and wound surface areas changes were analyzed to determine the effectiveness of the compound in wounds healing. Furthermore, drug safety was assessed by monitoring adverse events and by clinical and laboratory evaluations."nThe study data showed significant differences between the intervention and control groups with respect to efficacy and tolerability. In each intervention group, primary wound healings occurred following 2 weeks. Complete wound healing which was greater than 70% improvement in wounds surface areas was achieved in 83% and 100% of group 1 and group 2 participants, respectively after 6 weeks. On the other hand, at the same period of time, only 22.2% of patients in control group revealed complete healing. Therefore, ANGIPARSTM had significant positive effect in increasing the incidence of complete wound closure compared with control group (p = 0.042. However, our evaluations indicated that adding topical treatment with 3% gel once a day to the oral therapy with the same product did not make

  2. Handbook Preparation as a Tool for Self-Directed Learning Process: A Case Study on Endocrine Topic

    Science.gov (United States)

    Cerrah Ozsevgec, Lale; Ayas, Alipasa; Ozsevgec, Tuncay

    2010-01-01

    This study examines the effectiveness of handbook preparation as a method in the self-directed learning process of student teachers in teaching endocrine glands, and increasing their levels of knowledge. Thirty student teachers were selected from a biology department. A pencil and paper test and a clinical interview procedure were used to collect…

  3. SLN as a topical delivery system for Artemisia arborescens essential oil: In vitro antiviral activity and skin permeation study

    Science.gov (United States)

    Lai, Francesco; Sinico, Chiara; De Logu, Alessandro; Zaru, Marco; Müller, Rainer H; Fadda, Anna M

    2007-01-01

    The effect of SLN incorporation on transdermal delivery and in vitro antiherpetic activity of Artemisia arborescens essential oil was investigated. Two different SLN formulations were prepared using the hot – pressure homogenization technique, Compritol 888 ATO as lipid, and Poloxamer 188 and Miranol Ultra C32 as surfactants. Formulations were examined for their stability for two years by monitoring average size distribution and zeta potential values. The antiviral activity of free and SLN incorporated essential oil was tested in vitro against Herpes Simplex Virus-1 (HSV-1) by a quantitative tetrazolium-based colorimetric method (MTT), while the effects of essential oil incorporation into SLN on both the permeation through and the accumulation into the skin strata was investigated by using in vitro diffusion experiments through newborn pig skin and an almond oil Artemisia essential oil solution as a control. Results showed that both SLN formulations were able to entrap the essential oil in high yields and that the mean particle size increased only slightly after two years of storage, indicating a high physical stability. In vitro antiviral assays showed that SLN incorporation did not affect the essential oil antiherpetic activity. The in vitro skin permeation experiments demonstrated the capability of SLN of greatly improving the oil accumulation into the skin, while oil permeation occurred only when the oil was delivered from the control solution. PMID:18019840

  4. SLN as a topical delivery system for Artemisia arborescens essential oil: in vitro antiviral activity and skin permeation study.

    Science.gov (United States)

    Lai, Francesco; Sinico, Chiara; De Logu, Alessandro; Zaru, Marco; Müller, Rainer H; Fadda, Anna M

    2007-01-01

    The effect of SLN incorporation on transdermal delivery and in vitro antiherpetic activity of Artemisia arborescens essential oil was investigated. Two different SLN formulations were prepared using the hot-pressure homogenization technique, Compritol 888 ATO as lipid, and Poloxamer 188 and Miranol Ultra C32 as surfactants. Formulations were examined for their stability for two years by monitoring average size distribution and zeta potential values. The antiviral activity of free and SLN incorporated essential oil was tested in vitro against Herpes Simplex Virus-1 (HSV-1) by a quantitative tetrazolium-based colorimetric method (MTT), while the effects of essential oil incorporation into SLN on both the permeation through and the accumulation into the skin strata was investigated by using in vitro diffusion experiments through newborn pig skin and an almond oil Artemisia essential oil solution as a control. Results showed that both SLN formulations were able to entrap the essential oil in high yields and that the mean particle size increased only slightly after two years of storage, indicating a high physical stability. In vitro antiviral assays showed that SLN incorporation did not affect the essential oil antiherpetic activity. The in vitro skin permeation experiments demonstrated the capability of SLN of greatly improving the oil accumulation into the skin, while oil permeation occurred only when the oil was delivered from the control solution. PMID:18019840

  5. Freshman Health Topics

    Science.gov (United States)

    Hovde, Karen

    2011-01-01

    This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

  6. Topic Model for Graph Mining.

    Science.gov (United States)

    Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

    2015-12-01

    Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs. PMID:25616091

  7. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid

    International Nuclear Information System (INIS)

    Agricultural workers are encouraged to use sunscreen to decrease the risk of UV-related skin cancer. Our previous studies have shown certain commercial sunscreens to be penetration enhancers. The focus of this project is to determine whether active ingredients in sunscreen formulations (i.e., the UV absorbing components and insect repellants for the sunscreen/bug repellant combinations) also act as dermal penetration enhancers for herbicides in vitro. The total percentages of 2,4-dichlorophenoxyacetic acid (2,4-D) penetrating through hairless mouse skin in 24 h ranged from 54.9 ± 4.7 for the no sunscreen control to 86.9 ± 2.5 for padimate-o. Of the active ingredients tested (7.5% octyl methoxycinnamate, 7% octocrylene, 0.6% oxybenzone, 5% homosalate, 5% octyl salicylate, 8% padimate-o, 10% sulisobenzone, and 9.5% and 19% N,N-diethyl-m-toluamide [DEET]), all but octocrylene led to a significant increase in total 2,4-D penetration as compared to the control (P 3H2O penetration across mouse skin, indicating physical damage to the stratum corneum. Additional studies demonstrated that the penetration enhancement seen across hairless mouse skin also occurred with human skin. Thus, the active ingredients of sunscreen formulations enhance dermal penetration of the moderately lipophilic herbicide 2,4-D

  8. The future of topical analgesics.

    Science.gov (United States)

    Arnstein, Paul M

    2013-07-01

    Topically applied analgesic therapies have been used throughout history to treat a variety of patient conditions that present with pain. Before modem pharmaceuticals became readily available, mud-based emollients, salves, cold therapies, and other natural remedies were often used. Now we have effective therapies and are developing advanced topical analgesics as we learn more about the physiology and pathophysiology of pain. The use of topical analgesics may be associated with fewer patient systemic side effects than are seen with oral, parenteral, or transdermally administered agents, making the topical route of administration attractive to prescribers and patients. With further refinement of existing drugs and the development of novel agents, topical analgesics may offer relief for treating patient pain conditions that are currently challenging to treat, such as pain resulting from burns, wound debridement, and pressure ulcers. Recognizing the value of a multimodal approach, topical analgesics may offer a therapeutic option that can become part of a comprehensive treatment plan for the patient. With continued advancements in targeted drug-delivery systems, topical analgesics may be able to provide a method to prevent or reverse the phenomena of peripheral and central sensitization, or the neuroplastic changes believed to be responsible for the transition from acute to chronic pain states in patients. For those patients at risk for developing chronic pain states, such as complex regional pain syndrome, the combination of cutaneous stimulation (achieved through rubbing during application) and analgesic effects produced by the drug itself may prevent the disabling pain that often emerges during the subacute phase of disease. In summary, better utilization of currently available topical analgesics and continued research promise to ensure that topical analgesics are, and will continue to be, important tools in the treatment of patients with resistant pain. PMID

  9. Temporary shelter-in-place as protection against a release of airborne hazardous material : report of a literature search.; TOPICAL

    International Nuclear Information System (INIS)

    ''Temporary shelter-in place'' is the combination of prompt shelter-in-place (SIP) to minimize initial exposure to airborne hazardous material, followed by timely action to terminate this protection to minimize exposure to hazardous vapor accumulations in the shelter once the air outside becomes less hazardous than the air inside the shelter. Temporary SIP, if properly executed, is considered to be an effective way to protect populations from hazardous chemical vapors, especially from high concentrations for short periods. This is supported by laboratory and field experiments. The need for timely termination of temporary SIP as protection from infiltrated vapors is an integral component of a temporary SIP strategy. It was from this premise that Argonne National Laboratory (ANL) was asked to develop methodologies for deciding when and how to terminate SIP. These methodologies, in turn, could be the basis for site-specific operational guidelines (e.g., decision matrix, decision-tree, or algorithm) for terminating SIP on each of the eight Army chemical stockpile storage sites, and in the off-post communities surrounding them. This project consists of two tasks. Task 1 was to collect and analyze existing literature that might be relevant to the termination of temporary SIP. This report is the product of Task 1. Task 2, which will begin on 2 February 2001, will use the results of the literature search as the baseline to investigate the concepts associated with temporary SIP, and to develop methodologies for termination of temporary SIP that can be incorporated in site-specific operational guidelines. It is understood that these methods will be consistent with Chemical Stockpile Emergency Preparedness Program (CSEPP) policy that ''the most important objective of the emergency preparedness and implementation process is the avoidance of fatalities to the maximum extent practicable, should an accidental release of chemical agent occur.'' It is also anticipated that these

  10. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.

    Science.gov (United States)

    Goyanes, Alvaro; Det-Amornrat, Usanee; Wang, Jie; Basit, Abdul W; Gaisford, Simon

    2016-07-28

    Acne is a multifactorial inflammatory skin disease with high prevalence. In this work, the potential of 3D printing to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrated by two different 3D printing (3DP) technologies: Fused Deposition Modelling (FDM) and stereolithography (SLA). 3D scanning technology was used to obtain a 3D model of a nose adapted to the morphology of an individual. In FDM 3DP, commercially produced Flex EcoPLA™ (FPLA) and polycaprolactone (PCL) filaments were loaded with salicylic acid by hot melt extrusion (HME) (theoretical drug loading - 2% w/w) and used as feedstock material for 3D printing. Drug loading in the FPLA-salicylic acid and PCL-salicylic acid 3D printed patches was 0.4% w/w and 1.2% w/w respectively, indicating significant thermal degradation of drug during HME and 3D printing. Diffusion testing in Franz cells using a synthetic membrane revealed that the drug loaded printed samples released <187μg/cm(2) within 3h. FPLA-salicylic acid filament was successfully printed as a nose-shape mask by FDM 3DP, but the PCL-salicylic acid filament was not. In the SLA printing process, the drug was dissolved in different mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) (PEG) that were solidified by the action of a laser beam. SLA printing led to 3D printed devices (nose-shape) with higher resolution and higher drug loading (1.9% w/w) than FDM, with no drug degradation. The results of drug diffusion tests revealed that drug diffusion was faster than with the FDM devices, 229 and 291μg/cm(2) within 3h for the two formulations evaluated. In this study, SLA printing was the more appropriate 3D printing technology to manufacture anti-acne devices with salicylic acid. The combination of 3D scanning and 3D printing has the potential to offer solutions to produce personalised drug loaded devices, adapted in shape and size to individual patients. PMID:27189134

  11. Use of Immunostimulatory Sequence-Containing Oligonucleotides as Topical Therapy for Genital Herpes Simplex Virus Type 2 Infection

    Science.gov (United States)

    Pyles, Richard B.; Higgins, Debbie; Chalk, Claudia; Zalar, Anthony; Eiden, Joseph; Brown, Carrie; Van Nest, Gary; Stanberry, Lawrence R.

    2002-01-01

    Synthetic oligonucleotides containing CpG motifs in specific sequence contexts have been shown to induce potent immune responses. We have evaluated mucosal administration of two immunostimulatory sequence (ISS)-containing phosphorothioate-stabilized oligonucleotides for antiherpetic efficacy in animal models. The ISS oligonucleotides, suspended in phosphate-buffered saline, were tested in mouse and guinea pig vaginal models of herpes simplex virus type 2 (HSV-2) infection. For comparison, groups of untreated, non-ISS oligonucleotide-treated, and acyclovir-treated animals also were monitored. The results indicated that vaginal epithelial application of ISS (up to 6 h after viral inoculation) with mice lethally challenged with HSV-2 delayed disease onset and reduced the number of animals that developed signs of disease (P = 0.003). ISS application significantly increased survival rates over those of controls (P = 0.0014). The ISS also impacted an established infection in the guinea pig model of HSV-2 disease. A single administration of ISS (21 days after viral inoculation) significantly reduced the frequency and severity of HSV-2 lesions compared to results with non-ISS oligonucleotide-treated and untreated guinea pigs (P < 0.01). HSV-2 is shed from the vaginal cavity of the guinea pig in the absence of lesions, similar to the case with humans. As an additional indication of ISS efficacy, the magnitude of viral shedding also was significantly reduced in ISS-treated animals (P < 0.001). These effects appeared to be immunologically mediated, since ISS had no direct effect on HSV-2 replication in vitro using standard plaque assays. These data suggest that ISS may be useful in the treatment and control of genital herpes in humans. PMID:12388699

  12. Screening of Nanoemulsion Formulations and Identification of NB-201 as an Effective Topical Antimicrobial for Staphylococcus aureus in a Mouse Model of Infected Wounds.

    Science.gov (United States)

    Fan, Yongyi; Ciotti, Susan; Cao, Zhengyi; Eisma, Rone; Baker, James; Wang, Su He

    2016-05-01

    Despite advances in antimicrobial therapies, wound infection remains a global public health concern. We aimed to formulate and assess various nanoemulsions (NEs) for potential effectiveness as stable antimicrobial agents suitable for topic application. A total of 106 NEs were developed that varied with respect to nonionic and cationic surfactants. Stability testing demonstrated that the NEs tested are broadly stable, with 97/106 formulations passing 2-week stability tests. Two NEs, NB-201 and NB-402, were selected to test antimicrobial activity in a wound model in mice. Skin abrasion wounds were infected with Staphylococcus aureus followed by NE treatment. Infected skin was then evaluated by measuring colony forming units. NB-201 reduced median bacterial counts by 4 to 5 log compared to animals treated with saline, whereas NB-402 reduced bacterial counts by 2 to 3 log. Additional stability tests on NB-201 demonstrated that NB-201 is stable in the presence of human serum, and is stable for at least 6 months at 5°C, 25°C, and 40°C. Finally, in in vitro studies, NB-201 was found to be effective against S. aureus at a higher dilution than the commercially available silver sulfadiazine. Altogether these results demonstrate that NB-201 is a stable and effective topical antimicrobial for the treatment of S. aureus. PMID:27168582

  13. Music Perception as a Topic of Cognitive Psychology = Bilişsel Psikolojinin Bir Konusu Olarak Müzik Algısı

    Directory of Open Access Journals (Sweden)

    Aslı ASLAN

    2007-06-01

    Full Text Available Music perception has a long and distinguished history as a topic of psychological research because music requires a mental activity in humans. As a complex human activity, music perception is naturally an area of interest especially to cognitive psychology. Cognitive studies suggest that listener’s experience of a particular musical sequence is driven and at the same time constrained by the sounds registered by auditory mechanisms but also processed by available mental resources. This assumption indicates that researchers must take into account certain inherent limitations and capabilities of the listener. The main purpose of this paper is to discuss possible cognitive processes underlying music perception. The steps taken towards this purpose will be describing the structure of music and discussing the way that this structure is perceived by human cognition.

  14. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  15. Armorican arrowhead biographies: Production and function of an Early Bronze Age prestige good from Brittany (France

    Directory of Open Access Journals (Sweden)

    Clément Nicolas

    2014-09-01

    , etc.. According to these obvious facts, they symbolize the power of the elites. The genesis of Armorican arrowheads are in all likelihood explained by a climate of increasing social competition, which express itself in Brittany by an individualization of burial rites, a development of metalworking and a reorganization of territories.In this article, we will stress on raw materials selection, technology and know-how, as well as use-wear analyses. All these approaches will help us to trace the biographies of the Armorican arrowheads.

  16. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  17. Topical report review status

    International Nuclear Information System (INIS)

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  18. Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration.

    Science.gov (United States)

    Djekic, Ljiljana; Martinovic, Martina; Stepanović-Petrović, Radica; Tomić, Maja; Micov, Ana; Primorac, Marija

    2015-08-01

    Nonionic surfactants (caprylocaproyl macrogol-8 glycerides, octoxynol-12, polysorbate-20, and polyethylene glycol-40 hydrogenated castor oil) (47.03%, w/w), costabilizer (poloxamer 407) (12%-20%, w/w), oil (isopropyl myristate) (5.22%, w/w), water (q.s. ad 100%, w/w), and ibuprofen (5%, w/w) were used to develop oil-in-water microemulsions with Newtonian flow behavior, low viscosity (from 368 ± 38 to 916 ± 46 mPa s), and average droplet size from 14.79 ± 0.31 to 16.54 ± 0.75 nm. Ibuprofen in vitro release from the microemulsions was in accordance with zero-order kinetics (R0(2) > 0.99) for at least 12 h. The maximum drug release rate (3.55%h(-1) ) was from the microemulsion M3 comprising 16%, w/w of poloxamer 407. The release rate of ibuprofen from the reference hydrogel followed Higuchi kinetics (RH(2) > 0.99), and drug amount released after the 6th hour was negligible. In a rat model of inflammation, the microemulsion M3 was significantly more efficacious than the reference hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. No obvious skin irritation was observed in in vivo studies. The developed nonionic surfactants-based microemulsions containing the optimal concentration of poloxamer 407 could be promising carriers for sustained regional delivery of ibuprofen via topical administration. PMID:26045240

  19. Topical treatment of melasma

    OpenAIRE

    Bandyopadhyay Debabrata

    2009-01-01

    Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical ...

  20. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    International Nuclear Information System (INIS)

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8±0.59 times and MPD increased 2.75±0.5 and 6.8±1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au)

  1. The biography genre: a proposal of work from the rewriting process

    Directory of Open Access Journals (Sweden)

    Débora Sodré Esper

    2015-07-01

    Full Text Available This article aims to show a proposal of work with the biography genre together with text revision. It is based on studies related to the teaching-learning process of text production and on the theory of discourse genres (BAKHTIN, 1997. This work made use of 19 compositions by students of the 4th grade of Elementary School (ES from a private school of Maringá, Paraná State, and counted with the conduction of a survey on the main problems shown; from the results, a series of activities aiming at the learning of the genre referred was proposed.

  2. Fishy Hearing: A Short Biography of Arthur N. Popper, PhD.

    Science.gov (United States)

    Coffin, Allison B

    2016-01-01

    Biologist Dr. Arthur Popper's career spans decades, from his early work on comparative inner ear morphology in fishes to his recent interest in how underwater noise impacts aquatic vertebrates. Along the way Dr. Popper's research subjects span at least 19 vertebrate taxa, from lamprey to lungfish to humans, and he's had a profound influence in the field of fish bioacoustics. This brief biography describes some of Dr. Popper's many contributions to fish hearing research and highlights both some of his major discoveries and some of the biological mysteries he has yet to solve. PMID:26515307

  3. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  4. Serendipity: a personal tale of two biographies, William Richard Gowers (1845-1915) and his son Ernest (1880-1966).

    Science.gov (United States)

    Scott, Ann

    2015-08-01

    Between 2004 and 2012, the author wrote two biographies, the first of 20th century civil servant Ernest Gowers and the second of his father the Victorian neurologist William Richard Gowers. This article describes the author's experience conducting the research for two biographies at a time when the research tools available were rapidly shifting from paper-based to digital records. Technological aids have made the preliminary research of historians easier, but they have not taken the place of hard copy archive-based research. While the paper will focus primarily on the biography of William Richard Gowers, the author describes the research methods she employed to help reveal the personalities, strengths and weaknesses of both men, each of whom left his own intellectual legacy. PMID:26025849

  5. Biography and Discipline: Key Players in Simulation/Gaming

    Science.gov (United States)

    Kikkawa, Toshiko; Crookall, David

    2011-01-01

    This issue of S&G is devoted to people--to the gamers who have made and are making the exciting discipline of simulation gaming possible. All disciplines that hope for a bright future must record their origins and development. This is particularity the case for a field as fuzzy and interdisciplinary as simulation/gaming. The symposium dedicated to…

  6. An ionic liquid-in-water microemulsion as a potential carrier for topical delivery of poorly water soluble drug: Development, ex-vivo and in-vivo evaluation.

    Science.gov (United States)

    Goindi, Shishu; Kaur, Ramanpreet; Kaur, Randeep

    2015-11-30

    In this paper, we report an ionic liquid-in-water (IL/w) microemulsion (ME) formulation which is able to solubilize etodolac (ETO), a poorly water soluble drug for topical delivery using BMIMPF6 (1-butyl-3-methylimidazolium hexafluorophosphate) as IL, Tween 80 as surfactant and ethanol as co-surfactant. The prepared ME was characterized for physicochemical parameters, subjected to ex-vivo permeation studies as well as in-vivo pharmacodynamic evaluation. The ex-vivo drug permeation studies through rat skin was performed using Franz-diffusion cell and the IL/w based ME showed maximum mean cumulative percent permeation of 99.030±0.921% in comparison to oil-in-water (o/w) ME (61.548±1.875%) and oily solution (48.830±2.488%) of ETO. In-vivo anti-arthritic and anti-inflammatory activities of the prepared formulations were evaluated using different rodent models and the results revealed that ETO loaded IL/w based ME was found to be more effective in controlling inflammation than oily solution, o/w ME and marketed formulation of ETO. Histopathological studies also demonstrated that IL/w based ME caused no anatomical and pathological changes in the skin. PMID:26456294

  7. Michael J. Holden, Commander, United States Navy: a biography

    OpenAIRE

    Holden, Michael J.

    1996-01-01

    I am assigned as Military Faculty to the Naval Postgraduate School Computer Science Department and am simultaneously pursuing my doctorate. Among other things, my research concerns Software Engineering and Control Software for the NPS Phoenix robot minisubmarine.

  8. Biography, history and the Indonesian novel : Reading Salah Asuhan

    Directory of Open Access Journals (Sweden)

    Keith Foulcher

    2005-01-01

    Full Text Available The novel Salah Asuhan (Wrong Upbringing, written by the Indonesian nationalist politician and journalist Abdoel Moeis, has long held an honoured place in the modern Indonesian literary canon. It was originally published in 1928 by Balai Poestaka, the Netherlands Indies government printing house, and by 1995 it had been reprinted twenty-three times. In summary form, it has been studied by generations of Indonesian schoolchildren, and in 1972 it was adapted by Asrul Sani as a successful feature film. Critics and historians of modern Indonesian literature have always regarded Salah Asuhan as a literary milestone. It is admired for the maturity of its author’s literary imagination, as well as the modernity of its language and style. In linguistic terms, it is seen as one of the pioneering literary expressions of the language which was designated as Bahasa Indonesia in the very year of the novel’s publication. It exercises an additional fascination for literary critics and historians because of the circumstances of its publication. The form in which it was originally written is now unknown, for the novel was only published after a lengthy delay and a series of revisions which the author made to the text after seeing his manuscript languish for more than a year under the scrutiny of Balai Poestaka’s editors. As a result, the original conception of Salah Asuhan remains a mystery. Indeed, it is one of the greatest puzzles in a literary history that is so full of documentary lacunae that its serious study remains a source of ongoing challenge and frustration.

  9. Etienne-Jules Marey: a short biography and appreciation

    Science.gov (United States)

    Haddleton, Graham P.

    2003-07-01

    As a "son" of Beaune it seems appropriate to give a short appreciation of the work of Marey, as a pioneer in the field of high speed and motion recording photography, at this Congress held in his birthplace. Not only was he a notable physicist but he was a very often under appreciated pioneer of scientific photography, especially as applied to motion recording and analysis. It can be rightfully claimed that his work makes him an important element in the discovery of cinematography in general. His contemporary (and at times collaborator) Muybridge seems to have been credited with much of the acclaim in this field, possible because of his more extrovert character, and possible because of Marey's many other notable scientific achievements. Marey had invented a high-speed camera capable of 700 pps by 1894!

  10. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

    OpenAIRE

    Bahrami A; Kamali K; Ali-Asgharzadeh A; Hosseini P; Heshmat R; HR Khorram Khorshid; Gharibdoust F; SH Madani; Larijani B

    2008-01-01

    ANGIPARSTM is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARSTM and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities."nTwenty one patients with diabetic foot ulcers were divided into 3 groups. The first gro...

  11. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  12. Learning in Life History - psycho-societal interpretation of biographies

    DEFF Research Database (Denmark)

    Olesen, Henning Salling

    2008-01-01

    Taking its point of departure from some critical remarks about some of the most important recent theorizing of learning, this article presents an alternative framework for theorizing learning as a subjective process in a social and societal context, based on life history research. The key concept...

  13. A Survey of Topic Modeling in Text Mining

    Directory of Open Access Journals (Sweden)

    Rubayyi Alghamdi

    2015-01-01

    Full Text Available Topic models provide a convenient way to analyze large of unclassified text. A topic contains a cluster of words that frequently occur together. A topic modeling can connect words with similar meanings and distinguish between uses of words with multiple meanings. This paper provides two categories that can be under the field of topic modeling. First one discusses the area of methods of topic modeling, which has four methods that can be considerable under this category. These methods are Latent semantic analysis (LSA, Probabilistic latent semantic analysis (PLSA, Latent Dirichlet allocation (LDA, and Correlated topic model (CTM. The second category is called topic evolution models, which model topics by considering an important factor time. In the second category, different models are discussed, such as topic over time (TOT, dynamic topic models (DTM, multiscale topic tomography, dynamic topic correlation detection, detecting topic evolution in scientific literature, etc.

  14. Restabilizing attachment to cultural objects. Aesthetics, emotions and biography.

    Science.gov (United States)

    Benzecry, Claudio E

    2015-12-01

    The scholarship on aesthetics and materiality has studied how objects help shape identity, social action and subjectivity. Objects, as 'equipment[s] for living' (Luhmann 2000), become the 'obligatory passage points humans have to contend with in order to pursue their projects (Latour 1991). They provide patterns to which bodies can unconsciously latch onto, or help human agents work towards particular states of being (DeNora 2000, 2003). Objects are central in the long term process of taste construction, as any attachment to an object is made out of a delicate equilibrium of mediators, bodies, situations and techniques (Hennion and his collaborators (Hennion and Fouquet 2001; Hennion and Gomart 1999). In all of these accounts objects are the end result of long-term processes of stabilization, in which the actual material object (a musical piece, a sculpture, an art installation, a glass of wine, the oeuvre of Bach as we know it) is both a result and yet a key co-producer of its own generation. Whereas the literature has been generous and detailed in exploring the processes of assembling and sustaining object-centered attachments, it has not sufficiently engaged with what happens when the aesthetic elements of cultural artifacts that have produced emotional resonance are transformed: what do these artifacts morph into? What explains the transition (or not) of different cultural objects? And relatedly, what happens to the key aesthetic qualities that were so central to how the objects had been defined, and to those who have emotionally attached to them? To answer these questions, this article uses as exemplars two different cases of attachment, predicated on the distinctive features of a cultural object--the transcendence of opera and the authenticity of a soccer jersey--that have undergone transformations. PMID:26560345

  15. Biography, history and the Indonesian novel : Reading Salah Asuhan

    OpenAIRE

    Keith Foulcher

    2005-01-01

    The novel Salah Asuhan (Wrong Upbringing), written by the Indonesian nationalist politician and journalist Abdoel Moeis, has long held an honoured place in the modern Indonesian literary canon. It was originally published in 1928 by Balai Poestaka, the Netherlands Indies government printing house, and by 1995 it had been reprinted twenty-three times. In summary form, it has been studied by generations of Indonesian schoolchildren, and in 1972 it was adapted by Asrul Sani as a successful featu...

  16. Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation.

    Science.gov (United States)

    Tasic-Kostov, M; Pavlovic, D; Lukic, M; Jaksic, I; Arsic, I; Savic, S

    2012-10-01

    Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The α-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for α-tocopherol in the same vehicle. PMID:22691034

  17. Maps on the basis of the Arts & Humanities Citation Index: The journals Leonardo and Art Journal versus "Digital Humanities" as a topic

    CERN Document Server

    Leydesdorff, Loet

    2009-01-01

    The possibilities of using the Arts & Humanities Citation Index (A&HCI) for journal mapping have not been sufficiently recognized because of the absence of a Journal Citations Report (JCR) for this database. A quasi-JCR for the A&HCI (2008) was constructed from the data contained in the Web-of-Science and is used for the evaluation of two journals as examples: Leonardo and Art Journal. The maps on the basis of the aggregated journal-journal citations within this domain can be compared with maps including references to journals in the Science Citation Index and Social Science Citation Index. Art journals are cited by (social) science journals more than by other art journals, but these journals draw upon one another in terms of their own references. This cultural impact in terms of being cited is not found when documents with a topic such as "digital humanities" are analyzed. This community of practice functions more as an intellectual organizer than a journal.

  18. Biography of Jack Holland (1926-2014: Chert expert

    Directory of Open Access Journals (Sweden)

    William Engelbrecht

    2015-03-01

    Full Text Available Jack was born and grew up in Lock Haven Pennsylvania, the son of William G. Holland and Florence (Davies Holland. He had an older brother, William and a younger brother, Donald. Jack spent much of his boyhood roaming the surrounding flood plains of the West Branch of the Susquehanna River looking for arrowheads. As Jack recalled, his parents gave him a great deal of freedom, just asking that he be home in time for dinner. Dr. T. B. Stewart, a Lock Haven dentist, encouraged Jack’s early archaeological interest, helping him to identify specimens. Dr. Stewart had an extensive archaeological collection and had worked with Donald Cadzow, Pennsylvania’s State Archaeologist (1929-1939. Dr. Stewart was also one of the founders of the Society for Pennsylvania Archaeology, an organization with which Jack would later become involved and that bestowed their J. Alden Mason Award on him as a professional who encouraged society members in the “proper pursuit of archaeology.” 

  19. Shades of Venice in the Biography of Hegumen Pallady Rogovsky

    Directory of Open Access Journals (Sweden)

    Alexey Yastrebov

    2014-08-01

    Full Text Available Pallady Rogovsky was the first Russian doctor of theology and philosophy. While a student of the Slavyano-Greek-Latin Academy directed by the Brothers Lichudes, he left his homeland for the West in order to obtain a full university education. The years which he spent in Europe and particularly in Italy have attracted little notice on the part of Church historians. The study of unpublished materials in Italian archives together with those already published by the Russian researcher E. Shmurlo from the archive of the Propaganda de Fide and the Greek College, which however, remain unnoticed for the great majority of academics, permit us to have an idea of what occupied Rogovsky during this time, as well as to draw a more precise portrait of his personality. Most remarkable is the fact of his priestly ordination in the Roman Catholic Church and the correspondence relating to Rome’s acceptance of his Russian Orthodox diaconal ordination. One of the most informative documents found among those relating to his ordination and addressed to the Roman Curia is the letter of a Russian Catholic, the deacon (later defrocked Petr Artem’ev, in which Artem’ev revealed that Rogovsky already had converted to Roman Catholicism before he left Russia. Equally noteworthy is Rogovsky’s own letter which he composed while in Venice and in which he formulated his plans for the propagation of Roman Catholicism in Russia

  20. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  1. [Pathography and biography of the Empress Maria Theresa].

    Science.gov (United States)

    Habek, D; Masić, I

    2001-01-01

    The empress and queen Maria Theresa Habsburg-Lorraine (May 13th, 1917-November 29th, 1780) bore sixteen children in the marriage with the emperor Franz I Stepha and was famous as "mother-in-law of Europe". Her brother Leopold died immediately after he was born, her sister Amalia died in the cradle and Maria Ana died of perinatal complications at the birth of a dead infant in 1744. The famous hereditary facial dysmorphia of the "Hasburg jawe" wasn't noticed in Maria Theresa's surviving children. In October of 1738, after giving birth to her daughter Ana, a manual lysis of the placenta was performed due to the retained placenta and postpartal bleeding. In 1741 her daughter Carolina died, and in 1767 her daughter Josepha died of small pox. Her daughter Elizabeth remained deformed by the pock marks, and Maria Christina got a puerperal sepsis, but surprisingly, didn't die. Maria Antoinette ended under a guillotine in France, along with her husband Luis XVI. Maria Theresa's father, Karl VI died of the cholecystopankreatitis and peritonitis, and her husband and co-ruler most probably died of acute coronary incident in August 18th, 1765. After her husband's death she started suffering from depression with steady necrophile obsessions. Maria Theresa suffered from a chronical obstructional pulmonary disease (asthma), rehumatic syndromes, hypertension and anxiodepressive syndromes. In 1767 she had small pox. In November 11th 1780 she caught a cold which grew into a pneumonia with high fever. She died of cardiopulmonal dedompensation preceded by pneumonia and asthma. PMID:11769437

  2. Biografia intelektualna Emila Ciorana (Emil Cioran's Intellectual Biography

    Directory of Open Access Journals (Sweden)

    Sławomir Piechaczek

    2011-06-01

    Full Text Available On the formation of Cioran’s vision of the world and man, influenced largely his belonging to precisely this and no other nation. Romanian fatalism, inability to illusions, seeing the inevitable, the Romanian people’s faith in the fact that sin and creation are the same and constant accusations against this creation are the constitutiveelements of Cioran’s thought. Carrying the baggage of experiences of the nation thrown out of history and time, Cioran, as a Romanian emigrant in France, found the best model for his own writing in rhetorical and satirical tradition of the French moralists of the seventeenth and eighteenth centuries, who were a combination of“lyrical sublimity and cynicism”, gentleness and hell. They showed him not only what is uncompromising in pursuing the motives of human action, looking at every thing from many different perspectives, or suspicion of any kind of doctrine, but they also became for him a model of style. Of all literary forms cultivated by moralists, Cioranappreciated most the fragment, that is to say a closed form, often paradoxical and witty that having nothing in common with the characteristic for large systems long strings of argument – that was a form of recording experience, and like this experience, assumed discontinuity. Being a spokesperson for the “philosophy of the onlymoments”, Cioran advocated not only against the system, but also against academic philosophy – grown with indifference, regardless of the state of mind, it seemed to him the result of reduction of vitality and a kind of escape into the impersonal world of unrest. State, which fully made Cioran realize the futility resorting to this kind of philosophy, was insomnia, from which the Romanian philosopher had suffered more or less since he was seventeen. According to the author of the Fall in the Time insomnia and boredom are the “minimum imbalance”, which we have to experience, when we want to get closer to some

  3. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail. PMID:26991442

  4. Identifying Topics in Microblogs Using Wikipedia.

    Directory of Open Access Journals (Sweden)

    Ahmet Yıldırım

    Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

  5. Identifying Topics in Microblogs Using Wikipedia

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail. PMID:26991442

  6. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  7. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  8. Topics in Nuclear Astrophysics

    International Nuclear Information System (INIS)

    Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.)

  9. Topical anesthesia in phacoemulsification

    Directory of Open Access Journals (Sweden)

    Saad Waheeb

    2010-01-01

    Conclusion : Topical anesthesia is a satisfactory and safe alternative to retrobulbar and peribulbar anesthesia for clear corneal phacoemulsification and intraocular lens implantation in selected cataract patients in the hands of experienced cataract surgeon.

  10. Advanced Topics in Aerodynamics

    DEFF Research Database (Denmark)

    Filippone, Antonino

    1999-01-01

    "Advanced Topics in Aerodynamics" is a comprehensive electronic guide to aerodynamics,computational fluid dynamics, aeronautics, aerospace propulsion systems, design and relatedtechnology. We report data, tables, graphics, sketches,examples, results, photos, technical andscientific literature, for...

  11. Topical treatment of melasma

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Debabrata

    2009-01-01

    Full Text Available Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  12. Topical corticosteroid addiction and phobia

    Directory of Open Access Journals (Sweden)

    Aparajita Ghosh

    2014-01-01

    Full Text Available Corticosteroids, one of the most widely prescribed topical drugs, have been used for about six decades till date. However, rampant misuse and abuse down the years has given the drug a bad name. Topical steroid abuse may lead to two major problems which lie at the opposing ends of the psychosomatic spectrum. Topical steroid addiction, a phenomenon that came to be recognized about a decade after the introduction of the molecule is manifested as psychological distress and rebound phenomenon on stoppage of the drug. The rebound phenomenon, which can affect various parts of the body particularly the face and the genitalia has been reported by various names in the literature. TC phobia which lies at the opposite end of the psychiatric spectrum of steroid abuse has been reported particularly among parents of atopic children. Management of both conditions is difficult and frustrating. Psychological counseling and support can be of immense help in both the conditions.

  13. Topical corticosteroid addiction and phobia.

    Science.gov (United States)

    Ghosh, Aparajita; Sengupta, Sujata; Coondoo, Arijit; Jana, Amlan Kusum

    2014-09-01

    Corticosteroids, one of the most widely prescribed topical drugs, have been used for about six decades till date. However, rampant misuse and abuse down the years has given the drug a bad name. Topical steroid abuse may lead to two major problems which lie at the opposing ends of the psychosomatic spectrum. Topical steroid addiction, a phenomenon that came to be recognized about a decade after the introduction of the molecule is manifested as psychological distress and rebound phenomenon on stoppage of the drug. The rebound phenomenon, which can affect various parts of the body particularly the face and the genitalia has been reported by various names in the literature. TC phobia which lies at the opposite end of the psychiatric spectrum of steroid abuse has been reported particularly among parents of atopic children. Management of both conditions is difficult and frustrating. Psychological counseling and support can be of immense help in both the conditions. PMID:25284851

  14. Dwight D. Eisenhower: Man of Many Hats. With a Message from John S. D. Eisenhower. Picture-Book Biography Series.

    Science.gov (United States)

    Deitch, Kenneth M.; Weisman, JoAnne B.

    A biography of Dwight D. Eisenhower is presented in this book for young children. Born in Denison, Texas, Eisenhower was reared on a farm in Abilene, Kansas. After graduating from Abilene High School, he went on to attend the United States Military Academy at West Point. Among his many career highlights were earning the ranks of five-star general…

  15. Biographies of Heroes. Grade 2 Model Lesson for Standard 5. California History-Social Science Course Models.

    Science.gov (United States)

    Porter, Priscilla

    Students focus on people who make a difference. The unit features men and women whose achievements have had a direct or indirect influence in the students' lives. These individuals include heroes from long ago and the recent past along with people who are currently active in the local community. The unit is crafted around biographies. It aims to…

  16. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  17. Topics in statistical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references.

  18. Topics in statistical mechanics

    International Nuclear Information System (INIS)

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references

  19. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  20. Parent's alcoholism severity and family topic avoidance about alcohol as predictors of perceived stigma among adult children of alcoholics: Implications for emotional and psychological resilience.

    Science.gov (United States)

    Haverfield, Marie C; Theiss, Jennifer A

    2016-01-01

    Alcoholism is a highly stigmatized condition, with both alcohol-dependent individuals and family members of the afflicted experiencing stigmatization. This study examined the severity of a parent's alcoholism and family topic avoidance about alcohol as two factors that are associated with family members' perceptions of stigma. Three dimensions of stigma were considered: discrimination stigma, disclosure stigma, and positive aspect stigma. In addition, this study assessed associations between perceived stigmatization and individuals' experiences of depressive symptoms, self-esteem, and resilience. Adult children of alcoholics (N = 622) were surveyed about family conditions, perceived stigma, and their emotional and psychological well-being. Regression analyses revealed that the severity of a parent's alcoholism predicted all three types of stigma for females, but not for males. In addition, family topic avoidance about alcohol predicted all types of stigma for males and discrimination stigma and positive aspect stigma for females. With few exceptions, the three types of stigma predicted depressive symptoms, self-esteem, and resilience for both male and female adult children of alcoholics. The results are discussed in terms of their implications for promoting a family environment that mitigates stigma and encourages emotional and psychological well-being. In 2012, approximately 3.3 million deaths worldwide were due to the harmful use of alcohol (World Health Organization [WHO], 2014). Individuals who abuse alcohol are susceptible to a variety of negative health outcomes (Rehm et al., 2009) and display inappropriate social behaviors (Klingemann, 2001; Schomerus et al., 2011a). General societal perceptions tend to characterize alcohol-dependent individuals as irresponsible and lacking in self-control (Schomerus et al., 2011b). Research in the United Kingdom found that 54% of the population believes alcohol-dependent individuals are personally to blame for their own

  1. Topics in optics and music

    Science.gov (United States)

    Sparks, Andrew W.

    2012-10-01

    While the use of optics in the playback of music has been a tremendously successful technology and laser light shows are a common occurrence, other intersections of optics and music tend to be less well known. Topics such as optics-based instruments, performance tools and effects, instrument characterization and manufacturing, recording, playback, and signal processing are explored.

  2. The Health Curriculum: 500 Topics.

    Science.gov (United States)

    Byrd, Oliver E.

    2001-01-01

    This 1958 paper divides 500 health topics into 20 categories: health as a social accomplishment/social problem; nutrition; physical fitness; mental health and disease; heredity/eugenics; infection/immunity; chronic and degenerative disease; substance abuse; skin care; vision, hearing, and speech; dental health; safety; physical environment; health…

  3. Topics on Galactic Chemical Evolution

    OpenAIRE

    Prantzos, Nikos

    2011-01-01

    I discuss three different topics in Galactic chemical evolution:the "puzzling" absence of any observational signature of secondary elements ; the building of the Galactic halo in the framework of hierarchical galaxy formation, as evidenced from its metallicity distribution ; and the potentially important role that radial migration may play in the evolution of galactic disks, according to recent studies.

  4. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    19. winter school in Zakopane was devoted to selected topics in nuclear structure such as: production of spin resonances, heavy ions reactions and their applications to the investigation of high spin states, octupole deformations, excited states and production of new elements etc. The experimental data are ofen compared with theoretical predictions. Report contains 28 papers. (M.F.W.)

  5. Talking topically to artificial dialog partners: Emulating humanlike topic awareness in a virtual agent

    OpenAIRE

    Breuing, Alexa; Wachsmuth, Ipke; Filipe, Joaquim; Fred, Ana

    2013-01-01

    During dialog, humans are able to track ongoing topics, to detect topical shifts, to refer to topics via labels, and to decide on the appropriateness of potential dialog topics. As a result, they interactionally produce coherent sequences of spoken utterances assigning a thematic structure to the whole conversation. Accordingly, an artificial agent that is intended to engage in natural and sophisticated human-agent dialogs should be endowed with similar conversational abilities. This paper pr...

  6. Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Simon Mackie

    2010-01-01

    Conclusion. Trans-nasal endoscopic resection and topical 5-Fluorouracil could potentially offer an acceptable alternative treatment to the standard of cranio-facial resection. This should be investigated in trials with a longer followup period than this paper in order to directly compare the two treatment modalities.

  7. Skin oxygenation after topical application of liposome-entrapped benzyl nicotinate as measured by EPR oximetry in vivo: influence of composition and size.

    Science.gov (United States)

    Kristl, Julijana; Abramović, Zrinka; Sentjurc, Marjeta

    2003-01-01

    New and improved drug delivery systems are the important subject of much scientific research. The development of formulations that increase skin oxygenation and of methods for measuring oxygen levels in skin are important for dealing with healing processes affected by the level of oxygen. We have used EPR oximetry in vivo to compare the influence of liposomal formulations of different size and composition with that of hydrogel with respect to the action of the entrapped benzyl nicotinate (BN). Following the topical application of BN onto the skin of mice, pO2 increase was measured by low-frequency EPR as a function of time. The effect of BN was evaluated by 3 different parameters: lag-time, time needed for maximum pO2 increase, and overall effectiveness expressed by the area under the response-time curve. An increase in skin oxygenation was observed after BN application. The results show that the effect of BN incorporated in liposomes is achieved more rapidly than the effect from hydrophilic gel. The composition of the liposomes significantly affects the time at which BN starts to act and, to a lesser extent, the maximum increase of pO2 in skin and the effectiveness of BN action. However, the size of the liposomes influences both the effectiveness of BN action and the time at which BN starts to act. After repeated application of liposomes, the pO2 baseline increased and the response of the skin tissue was faster. Our results demonstrate that EPR oximetry is a useful method for evaluating oxygen changes after drug application and for following the time course of their action. PMID:12713274

  8. Topical Products for the Aging Face.

    Science.gov (United States)

    McCook, John P

    2016-07-01

    This article focuses on nonprescription home-use topical treatment technologies for the aging face and is intended to serve as a guide for the core cosmeceutical technologies currently used and to help educate and assist the selection of topical antiaging products by the professional staff and their patients. Antiaging topical treatments for patient home use should be nonirritating, compatible with the patient skin type, effective, and complementary to surgical and minimally invasive office procedures, and aesthetically elegant. New topical antiaging technologies, formulated as monotherapy or as combinations with well-known cosmeceuticals, should present adequate clinical studies to support their selection for use. PMID:27363774

  9. Posture et biographie : Semmelweis de L.-F. Céline

    OpenAIRE

    Jérôme Meizoz

    2008-01-01

    Il [Céline] ajoutait que si je voulais faire sa biographie, je n'aurais qu'à me servir de mon imagination, causer avec ses amis, dessiner mon propre portrait en le donnant pour sien, me réserver toutes les questions intelligentes et lui laisser toutes les réponses stupides. Hindus (Milton), L.-F. Céline tel que je l'ai vu, Paris, L'Herne, 1969, p. 44. Qui accède au statut d’« auteur » propose de lui-même une image publique qui s’affranchit en partie de ses coordonnées civiles, comme l’illustr...

  10. Kulchitsky's Casus: Materials To The Biography Of Professor N.K. Kulchitsky

    Directory of Open Access Journals (Sweden)

    В.В. Голубинов

    2009-09-01

    Full Text Available In 2009 in two foreign medical editions the detailed biography of professor N.K.Kulchitsky (1856 — 1925 has been first published. N.K.Kulchitsky, the world famous Russian scientist, histologist, professor, Senator and the last Minister of education of Imperial Russia, in 1912-1914 was the director of Kazan educational district to which Saratov University also belonged at that time. V.V. Golubinov — one of the publications authors, the great-grandson of N.K.Kulchitsky, graduate of Saratov University n.a. N.G.Chernyshevsky, psychologist and designer-schedule is the author of the emblem of Saratov Medical University which decorates our journal's cover narrates about his great-grandfather

  11. éphémérides ou biographie sommaire de Savinien de Cyrano de Bergerac

    Directory of Open Access Journals (Sweden)

    Madeleine Alcover

    2010-02-01

    Full Text Available Biographie15519 avril : mariage, à Paris, des grands-parents paternels de l’écrivain, Savinien I de Cyrano et Anne Le Maire : celle-ci est la petite-fille d’Étienne Cardon, marchand parisien. À ce jour, l’origine du grand-père paternel n’est pas résolue (sarde ? descendant d’un marchand bourrelier de Sens ?.1555Le couple signe une donation entre vifs qui, en cas de décès, fait du survivant son légataire universel. Quatre enfants leur survivront : Abel, Samuel, Pierre et Anne.1555-1560Savinie...

  12. Quest for professionalism: a biography of the North American Medical and Surgical Journal (1826-31).

    Science.gov (United States)

    Shultz, S M

    2011-08-01

    This is the biography of a deceased medical journal, the North American Medical and Surgical Journal, born in 1826 in Philadelphia. It was a publication of the Philadelphia Chapter of the Kappa Lambda Society. In the prospectus of the North American Medical and Surgical Journal the promoters observed that a well-conducted journal would achieve the object of elevating the medical profession to its legitimate rank which up to that time had been the recipient of low public opinion. The Journal hoped to inculcate 'a higher standard of excellence not merely in the professional or ministrative but also in the ethical relations and duties of physicians'. After several successful and productive years it passed into history in October 1831, the victim of financial difficulty. PMID:21810854

  13. A life of Erwin Schroedinger. 2. ed.; Erwin Schroedinger. Eine Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Walter J.

    2015-07-01

    Erwin Schroedinger (1887-1961) was a pioneer of quantum physics, one of the most important scientist of the 20th century at all and a charming Austrian. He was a man with a passionate interest for men and ideas. Mostly known he became by his representation of quantum theory in the form of wave mechanics, for which he obtained the Nobel prize for physics and naturally by the famous thought experiment ''Schroedingers cat''. Walter Moore's biography is quite near to the person of Schroedinger and presents his scientific work in the context of his friendships, his interset for mysticism, and in front of the moving background of the political events in Germany and Austria.

  14. Topic Identification in Discourse

    OpenAIRE

    Chen, Kuang-hua

    1995-01-01

    This paper proposes a corpus-based language model for topic identification. We analyze the association of noun-noun and noun-verb pairs in LOB Corpus. The word association norms are based on three factors: 1) word importance, 2) pair co-occurrence, and 3) distance. They are trained on the paragraph and sentence levels for noun-noun and noun-verb pairs, respectively. Under the topic coherence postulation, the nouns that have the strongest connectivities with the other nouns and verbs in the di...

  15. Severe photosensitivity reaction induced by topical diclofenac

    Directory of Open Access Journals (Sweden)

    Pramod B Akat

    2013-01-01

    Full Text Available Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

  16. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  17. Towards Automatic Topical Classification of LOD Datasets.

    OpenAIRE

    Meusel, R, Spahiu, B, Bizer, C, Paulheim, H

    2015-01-01

    The datasets that are part of the Linking Open Data cloud diagram (LOD cloud) are classified into the following topical categories: media, government, publications, life sciences, geographic, social networking, user-generated content, and cross-domain. The topical categories were manually assigned to the datasets. In this paper, we investigate to which extent the topical classification of new LOD datasets can be automated using machine learning techniques and the existing annotations as super...

  18. Genius in the shadows a biography of Leo Szilard, the man behind the bomb

    CERN Document Server

    Lanouette, William

    2013-01-01

    Well-known names such as Albert Einstein, Enrico Fermi, J. Robert Oppenheimer, and Edward Teller are usually those that surround the creation of the atom bomb. One name that is rarely mentioned is Leo Szilard, known in scientific circles as "father of the atom bomb." The man who first developed the idea of harnessing energy from nuclear chain reactions, he is curiously buried with barely a trace in the history of this well-known and controversial topic.Born in Hungary and educated in Berlin, he escaped Hitler's Germany in 1933 and that first year developed his concept of nucle

  19. Topic: Mastery Learning.

    Science.gov (United States)

    Killoran, James, Ed.

    1983-01-01

    This journal issue addresses the topic of mastery learning at both the elementary and secondary school levels. The first article, "The Theory and Practice of Mastery Learning" (Guskey), gives a definition of and information about the development, operation, and application of mastery learning, based on the theories of Benjamin Bloom. In addition,…

  20. Topical Research: Africa.

    Science.gov (United States)

    Lynn, Karen

    This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

  1. Contrastive topics decomposed

    Directory of Open Access Journals (Sweden)

    Michael Wagner

    2012-12-01

    Full Text Available The analysis of contrastive topics introduced in Büring 1997b and further developed in Büring 2003 relies on distinguishing two types of constituents that introduce alternatives: the sentence focus, which is marked by a FOC feature, and the contrastive topic, which is marked by a CT feature. A non-compositional rule of interpretation that refers to these features is used to derive a topic semantic value, a nested set of sets of propositions. This paper presents evidence for a correlation between the restrictive syntax of nested focus operators and the syntax of contrastive topics, a correlation which is unexpected under this analysis. A compositional analysis is proposed that only makes use of the flatter focus semantic values introduced by focus operators. The analysis aims at integrating insights from the original analysis while at the same time capturing the observed syntactic restrictions. http://dx.doi.org/10.3765/sp.5.8 BibTeX info

  2. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...

  3. Topic Tracking with Dynamic Topic Model and Topic-based Weighting Method

    Directory of Open Access Journals (Sweden)

    Xiaoyan Zhang

    2010-05-01

    Full Text Available In topic tracking, a topic is usually described by several stories. How to represent a topic is always an issue and a difficult problem in the research on topic tracking. To emphasis the topic in stories, we provide an improved topic-based tf*idf weighting method to measure the topical importance of the features in the representation model. To overcome the topic drift problem and filter the noise existed in the tracked topic description, a dynamic topic model is proposed based on the static model. It extends the initial topic model with the information from the incoming related stories and filters the noise using the latest unrelated story. The topic tracking systems are implemented on the TDT4 Chinese corpus. The experimental results indicate that both the new weighting method and the dynamic model can improve the tracking performance.

  4. The treatment of rosacea with topical ivermectin.

    Science.gov (United States)

    Ali, S T; Alinia, H; Feldman, S R

    2015-04-01

    The treatment of rosacea is challenging because several pathophysiologic processes may be involved, including neurovascular dysregulation and alterations in innate immune status. Demodex mites may play a role in the latter mechanism. Topical ivermectin is a new therapeutic modality which demonstrates antiparasitic and anti-inflammatory properties. This article reviews published evidence related to the efficacy and safety of topical ivermectin. PubMed was utilized to search for key words "topical ivermectin", "ivermectin cream" and "rosacea". Three clinical trials were found that studied topical ivermectin as a treatment option for rosacea. Ivermectin was effective, safe and well tolerated. PMID:26020066

  5. Updates of Topical and Local Anesthesia Agents.

    Science.gov (United States)

    Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

    2016-04-01

    As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. PMID:27040295

  6. Large scale topic modeling made practical

    DEFF Research Database (Denmark)

    Wahlgreen, Bjarne Ørum; Hansen, Lars Kai

    2011-01-01

    Topic models are of broad interest. They can be used for query expansion and result structuring in information retrieval and as an important component in services such as recommender systems and user adaptive advertising. In large scale applications both the size of the database (number of...... topics at par with a much larger case specific vocabulary....

  7. Topics and topic prominence in two sign languages

    NARCIS (Netherlands)

    V. Kimmelman

    2015-01-01

    In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and non

  8. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    OpenAIRE

    Sung-Chien Lin

    2014-01-01

    In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results ...

  9. Discovering Health Topics in Social Media Using Topic Models

    OpenAIRE

    Paul, Michael J.; Dredze, Mark

    2014-01-01

    By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM...

  10. Asude Bahar Ülkesine Yolculuk Olan Ölümün Şair Biyografilerinde İfade Edilmesi In Poet Biographies Expression Of Death A Passage To The Peaceful Spring Country

    Directory of Open Access Journals (Sweden)

    Abdullah AYDIN

    2013-09-01

    Full Text Available Collection of biographies of poets the sources of Classic TurkishLiterature inform about the poets’ life, character, literal personality andworks. Though the number of collection of biographies in TurkishLiterature has risen to forty, it will increase in number by newresearches possibly. There are both books and articles about how somespecific subjects are held on these works that involve the biographies ofpoets. Along with the informations about the poet’s character, physicalappearance, family, educational background, job, marriage, children,date of birth, place of birth, place of death there are information abouthis poesy.In this study, how the death of the poets are expressed isresearched inspring especially from the writers’ acting responsiblytowards indicating the date of death. The distinctness is formed byexamining former published works and identifying the samples whichwill complete them. Apart from the cause and time of death the wordsand word groups preferred for death knell are examined in terms ofstyle. While the death of poets are expressed by some simple sentencesas “died, expired, slaughtered” sometimes it is expressed in moreartistic ways related to poet’s name, nickname, job and lifestyle.Especially the tenth topic with its under titles is important in terms ofrevealing new styles of expression.Death which we regard ordinary by saying “all livings born, liveand die” and which is expressed in wholy Koran as “Külli nefsinzâikatü'l-mevt”, namely “every soul shall have a taste of death” is holdsometimes sadly but mostly in terms of its beauty. The writers havedeveloped a literary pleasure on death. Klasik Türk Edebiyatının kaynak eserlerinden Şair Tezkireleri şairlerin hayatı, mizacı, edebî kişiliği ve eserleri hakkında bilgi vermektedir. Türk Edebiyatında tezkire sayısı kırka ulaşmış olmakla beraber yeni araştırmalarla bu sayının artması muhtemeldir. Şair biyografilerini kapsayan

  11. Hot topic [editorial

    International Nuclear Information System (INIS)

    simulations 'would be seriously in error'. One may ask if this magazine should give space to Lindzen or those involved in geoengineering to air their views. Given the uncertainties still present within climate models and the potential costs of dealing with global warming, it would be wrong for Physics World to ignore those outside the mainstream. After all, as Richard Feynman once wrote: 'There is no harm in doubt and scepticism, for it is through these that new discoveries are made'. Physicists should never take anything at face value, not least a topic as important as climate change. (U.K.)

  12. Topical retinoids for acne.

    Science.gov (United States)

    Yeh, Lindsey; Bonati, Lauren Meshkov; Silverberg, Nanette B

    2016-06-01

    Topical retinoids are currently approved by the US Food and Drug Administration for the treatment of acne vulgaris in nonpregnant, nonlactating patients 12 years of age and older. Their efficacy, safety, and tolerability are well documented for inflammatory and noninflammatory acne with studies repeatedly demonstrating a decrease in the number of lesions, significant improvement in acne severity, improvement in the cosmetic appearance of acne, and the prevention of acne lesions through microcomedone formation. There is some variability between prescription retinoid products regarding efficacy, safety, and tolerability; with erythema, peeling, and dryness being common, potential side effects. Due to their efficacious and safe profile, topical retinoids remain the first-line treatment for acne vulgaris. PMID:27416308

  13. Four (Somewhat Nonstandard) Research Topics

    OpenAIRE

    Paun, Gheorghe; Research Group on Natural Computing (Universidad de Sevilla) (Coordinador)

    2014-01-01

    Four research directions are suggested, dealing with the following four main ideas: computing along the axon (up to now, this topic was only preliminarily investi- gated), using pre-computed resources in order to solve computationally hard problems, considering in P systems both objects \\of matter" and \\of anti-matter" (which annihilate each other when meet), and considering the distance (naturally de ned in a membrane structure of a given type) as a support of information.

  14. The personal is professional: Connecting white urban middle school science teachers' biographies to their teaching of all students

    Science.gov (United States)

    Oey, Esther Ruth

    The purpose of this study was to examine if and in what ways white, urban middle school science teachers use experiences of being marginalized or feeling different to connect to students coming from backgrounds unlike their own---especially students who are racially, culturally, linguistically and otherwise different from them, the school culture and the dominant society. Personal biography was used to frame this study. Data consisted of structured and semi-structured interviews and classroom observations of one female and two male science teachers gathered over one academic year. Results indicated that experiences with difference may be used to inform teachers' practices, but personal biography alone was insufficient to enable the teachers to reflect on their experiences with race, class, gender, and difference. Also, attending to emotions appeared to be an important factor in helping students develop cognitive skills in science classrooms.

  15. An irresponsible biography of the actor Laurence Harvey: motion pictures, white wine, older women & long thin cigarettes

    OpenAIRE

    Brannon, Matthew

    2015-01-01

    Tiré du site Internet de Onestar Press: "Pocket edition of Laurence Harvey's "irresponsible" biography by Matthew Brannon. From the back cover of the book : Call yourself an actor ? You're not even a bad actor. You can't act at all, you fucking stupid hopeless sniveling little cunt-faced cunty fucking shit-faced arse-hole ... LAURENCE OLIVIER to Laurence Havery from Robert Stephen's "Knight errant : memoirs of a vagabond actor", Hodder and Stoughton, 1995.".

  16. Automatic labelling of topic models learned from Twitter by summarisation

    OpenAIRE

    Cano Basave, Amparo Elizabeth; He, Yulan; Xu, Ruifeng

    2014-01-01

    Latent topics derived by topic models such as Latent Dirichlet Allocation (LDA) are the result of hidden thematic structures which provide further insights into the data. The automatic labelling of such topics derived from social media poses however new challenges since topics may characterise novel events happening in the real world. Existing automatic topic labelling approaches which depend on external knowledge sources become less applicable here since relevant articles/concepts of the ext...

  17. Correlated Topic Model for Web Services Ranking

    Directory of Open Access Journals (Sweden)

    Mustapha AZNAG

    2013-07-01

    Full Text Available With the increasing number of published Web services providing similar functionalities, it’s very tedious for a service consumer to make decision to select the appropriate one according to her/his needs. In this paper, we explore several probabilistic topic models: Probabilistic Latent Semantic Analysis (PLSA, Latent Dirichlet Allocation (LDA and Correlated Topic Model (CTM to extract latent factors from web service descriptions. In our approach, topic models are used as efficient dimension reduction techniques, which are able to capture semantic relationships between word-topic and topic-service interpreted in terms of probability distributions. To address the limitation of keywords-based queries, we represent web service description as a vector space and we introduce a new approach for discovering and ranking web services using latent factors. In our experiment, we evaluated our Service Discovery and Ranking approach by calculating the precision (P@n and normalized discounted cumulative gain (NDCGn.

  18. Balancing Biography and Institutional History: Eric Worrell’s Australian Reptile Park

    Directory of Open Access Journals (Sweden)

    Nancy Cushing

    2009-11-01

    Full Text Available When a young naturalist opened his new wildlife park at Wyoming on the NSW Central Coast in the late 1950s, he gave it his own name: Eric Worrell’s Australian Reptile Park. Through the park, Worrell made a significant contribution to environmental education, the development of knowledge of captive animal care and display and the provision of antivenoms for the bites of a range of dangerous creatures. More than this, it was the geographic and emotional centre of Worrell’s world: the fulfilment of a childhood dream, a home for his family and a site for forming new personal and professional relationships. In preparation for the jubilee of the park, its history is being written by two academics from the University of Newcastle. An attractive means of creating the necessary narrative structure and human interest to ensure the wide appeal of this history is to follow Worrell’s lead and place his life at the centre of this institutional history. This is the direction suggested by the written sources on the park and it is accentuated by many of our oral informants who organise their memories of the park around Worrell. To what extent can an institutional history be a biography of the person at the heart of that institution? Is it possible to disentangle the life from the institution? This article offers some preliminary answers to these questions through a case study of the writing of a history of Eric Worrell’s Australian Reptile Park.

  19. [Historical origin of Jiu Tangshu·biography of Sun Simiao].

    Science.gov (United States)

    Song, Zhen-Min

    2012-09-01

    The book Datang Xinyu·Sun Simiao was compiled by Liu Su according to the original national historical papers of the Tang Dynasty which basically kept the features of national history. Based on this book and Binglishufu Xu (written by Lu Zhaolin) and Tanbinlu·Sun Simiao, Zhang Du sorted out the data about Sun Simiao and compiled the book Xuanshizhi·Sun Simiao (in which the three stories of his lifetime were made up). Jiu Tangshi·Sun Simiao was edited by historiographers in the Hou-Jin Dynasty according to the biography of Sun Simiao in Tang national history, and referring to the Datang Xinyu·Sun Simiao, Xuanshizhi·Sun Simiao, in which they only made a few adjustments on the basis of Xuanshizhi. Du Guangting compiled Xianzhuan Shiyi·Sun Simiao and Xuanshizhi·Sun Simiao and added three stories of gods and spirits about Sun Simiao after he became immortal. Taipingguangji of the North Song Dynasty was compiled according to Xianzhuan Shiyi·Sun Simiao and Xuanshizhi·Sun Simiao. PMID:23336307

  20. Topics in commutative ring theory

    CERN Document Server

    Watkins, John J

    2009-01-01

    Topics in Commutative Ring Theory is a textbook for advanced undergraduate students as well as graduate students and mathematicians seeking an accessible introduction to this fascinating area of abstract algebra. Commutative ring theory arose more than a century ago to address questions in geometry and number theory. A commutative ring is a set-such as the integers, complex numbers, or polynomials with real coefficients--with two operations, addition and multiplication. Starting from this simple definition, John Watkins guides readers from basic concepts to Noetherian rings-one of

  1. "Draw My Topics": Find Desired Topics fast from large scale of Corpus

    OpenAIRE

    Dou, Jason; Sun, Ni; Zou, Xiaojun

    2016-01-01

    We develop the "Draw My Topics" toolkit, which provides a fast way to incorporate social scientists' interest into standard topic modelling. Instead of using raw corpus with primitive processing as input, an algorithm based on Vector Space Model and Conditional Entropy are used to connect social scientists' willingness and unsupervised topic models' output. Space for users' adjustment on specific corpus of their interest is also accommodated. We demonstrate the toolkit's use on the Diachronic...

  2. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments and Pregnancy In every pregnancy, a woman starts out with a 3-5% chance of having ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  3. Topical tretinoin in acanthosis nigricans

    Directory of Open Access Journals (Sweden)

    Lahiri Koushik

    1996-01-01

    Full Text Available Efficacy of topical tretinoin was assessed in 30 cases of idiopathic acanthosis nigricans which were recalcitrant to conventional modalities of treatment. Topical tretinoin once at night application was found to be very effective both clinically and histologically.

  4. Topical tretinoin in acanthosis nigricans

    OpenAIRE

    Lahiri Koushik; Malakar Subrata

    1996-01-01

    Efficacy of topical tretinoin was assessed in 30 cases of idiopathic acanthosis nigricans which were recalcitrant to conventional modalities of treatment. Topical tretinoin once at night application was found to be very effective both clinically and histologically.

  5. Modern topics in electron scattering

    CERN Document Server

    Frois, Bernard

    1991-01-01

    This book summarizes the considerable progress recently achieved in the understanding of nucleon and nuclear structure by using high energy electrons as a probe. A collection of papers discusses in detail the new frontiers of this field. Experimental and theoretical articles cover topics such as the structure of the nucleon, nucleon distributions, many-body correlations, non-nucleonic degrees of freedom and few-body systems. This book is an up-to-date introduction to the research planned with continuous beam electron accelerators.

  6. Recent Advances In Topical Therapy In Dermatology

    OpenAIRE

    Mohan Thappa Devinder

    2003-01-01

    With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological co...

  7. Topics in strangeness nuclear physics

    International Nuclear Information System (INIS)

    Strangeness nuclear physics bears a broad impact on contemporary physics since it lies at the intersection of nuclear and elementary particle physics, having, moreover, significant implications to the astrophysics of compact objects. This set of extensive lectures presents a balanced theoretical and experimental introduction to, and survey of, the field, addressing topics such as the production and spectroscopy of strange nuclear systems, modern approaches to the hyperon-nucleon interaction, and weak decays of hypernuclei. With new experiments underway, this burgeoning research field is well served by this tutorial primer and review for both newcomers and seasoned researchers alike. (orig.)

  8. Digital Social Network Mining for Topic Discovery

    Science.gov (United States)

    Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

    Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

  9. Control of pain with topical plant medicines

    Institute of Scientific and Technical Information of China (English)

    James; David; Adams; Jr.; Xiaogang; Wang

    2015-01-01

    Pain is normally treated with oral nonsteroidal anti-inflammatory agents and opioids. These drugs are dangerous and are responsible for many hospitalizations and deaths. It is much safer to use topical preparations made from plants to treat pain, even severe pain. Topical preparations must contain compounds that penetrate the skin, inhibit pain receptors such as transient receptor potential cation channels and cyclooxygenase-2, to relieve pain. Inhibition of pain in the skin disrupts the pain cycle and avoids exposure of internal organs to large amounts of toxic compounds. Use of topical pain relievers has the potential to save many lives, decrease medical costs and improve therapy.

  10. Topic-focused Dynamic Information Filtering in Social Media

    OpenAIRE

    Zhu, Yadong; Lan, Yanyan; Guo, Jiafeng; Cheng, Xueqi

    2015-01-01

    With the quick development of online social media such as twitter or sina weibo in china, many users usually track hot topics to satisfy their desired information need. For a hot topic, new opinions or ideas will be continuously produced in the form of online data stream. In this scenario, how to effectively filter and display information for a certain topic dynamically, will be a critical problem. We call the problem as Topic-focused Dynamic Information Filtering (denoted as TDIF for short) ...

  11. PUBLICATIONS OF MYKOLAS BIRZISKA IN VILNIUS PRESS AT THE BEGINNING OF THE 20TH CENTURY: FEATURES OF THE INTELLECTUAL BIOGRAPHY

    Directory of Open Access Journals (Sweden)

    Kvietkauskas, Mindaugas

    2006-12-01

    Full Text Available Mykolas Birziska (1882–1962 was a prominent Lithuanian scholar and politic, a signatory of the Act of Independence (1918, a member of Lithuanian Council (1917–1920, director of the first Lithuanian Gymnasium of Vytautas the Great in Vilnius (1915–1922, professor and rector of Kaunas and Vilnius universities. This articles deals with his early journalistic activities and editorship in the press in Vilnius before the outbreak of the First World War, and seeks to analyze the formation of his intellectual and political attitudes. In 1905, being a member of the Party of Lithuanian Social Democrats, Birziska began his journalistic career in socialist press. In 1906 heedited a party newspaper “Echo” in Polish language, where his specific interest in cooperation between different nationalities first became vivid. At the same time he began contributing to theliberal and antinationalist newspaper of the Polish krajovtsy movement “Gazeta Wileñska” (edited by Michal Römer, that argued for the political equality and tolerant cultural coexistence of allthe national groups in Lithuania. After the closure of “Gazeta Wileñska”, Birziska in 1907–1908 cooperated with another liberal daily in Russian language “Severo-Zapadnyj Golos”. Writing in threelanguages and simultaneously contributing to Lithuanian, Polish, and Russian press, Birziska exercised a specific role of a publicist as a mediator between different cultural groups in the multinational city. Professional analysis of the national conflicts, the principals of cultural tolerance and liberal antinationalist outlooks became the dominant features of his trilingual journalistic texts. Consequently, Birziska seeked to realize these intellectual attitudes working at the Lithuanian daily “Vilniaus zinios” in 1908 and especially editing the journal “Visuomene” (1910–1911 for the Lithuanian leftist intelligentsia. Birziska’s journalistic activities and his early intellectual

  12. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2014-07-01

    Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

  13. Hierarchical topic modeling with nested hierarchical Dirichlet process

    Institute of Scientific and Technical Information of China (English)

    Yi-qun DING; Shan-ping LI; Zhen ZHANG; Bin SHEN

    2009-01-01

    This paper deals with the statistical modeling of latent topic hierarchies in text corpora. The height of the topic tree is assumed as fixed, while the number of topics on each level as unknown a priori and to be inferred from data. Taking a nonparametric Bayesian approach to this problem, we propose a new probabilistic generative model based on the nested hierarchical Dirichlet process (nHDP) and present a Markov chain Monte Carlo sampling algorithm for the inference of the topic tree structure as welt as the word distribution of each topic and topic distribution of each document. Our theoretical analysis and experiment results show that this model can produce a more compact hierarchical topic structure and captures more free-grained topic relationships compared to the hierarchical latent Dirichlet allocation model.

  14. Advanced verification topics

    CERN Document Server

    Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

    2011-01-01

    The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

  15. 75 FR 26647 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

    Science.gov (United States)

    2010-05-12

    ... parasites that were approved for the pioneer product with 3 years of marketing exclusivity (69 FR 501... HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... part 524 is amended as follows: PART 524--OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS 0 1....

  16. Detection of Embryonic Research Topics by Analysing Semantic Topic Networks

    OpenAIRE

    Salatino, Angelo Antonio; Motta, Enrico

    2016-01-01

    Being aware of new research topics is an important asset for anybody involved in the research environment, including researchers, academic publishers and institutional funding bodies. In recent years, the amount of scholarly data available on the web has increased steadily, allowing the development of several approaches for detecting emerging research topics and assessing their trends. However, current methods focus on the detection of topics which are already associated with a label or a sub...

  17. Structured and Unstructured Cache Models for SMT Domain Adaptation

    OpenAIRE

    Louis, Annie; Webber, Bonnie L.

    2014-01-01

    We present a French to English translation system for Wikipedia biography articles. We use training data from out-of-domain corpora and adapt the system for biographies. We propose two forms of domain adaptation. The first biases the system towards words likely in biographies and encourages repetition of words across the document. Since biographies in Wikipedia follow a regular structure, our second model exploits this structure as a sequence of topic segments, where each segment discusses a ...

  18. A Survey On Interactivity in Topic Models

    Directory of Open Access Journals (Sweden)

    Patrik Ehrencrona Kjellin

    2016-04-01

    Full Text Available Trying to make sense and gain deeper insight from large sets of data is becoming a task very central to computer science in general. Topic models, capable of uncovering the semantic themes pervading through large collections of documents, have seen a surge in popularity in recent years. However, topic models are high level statistical tools; their output is given in terms of probability distributions, suited neither for simple interpretation nor deep analysis. Interpreting the fitted topic models in an intuitive manner requires visual and interactive tools. Additionally, some measure of human interaction is typically required for refining the output offered by such models. In the research, this area remains relatively unexplored – only recently has this aspect been receiving more attention. In this paper, the literature is surveyed as it pertains to interactivity and visualisation within the context of topic models, with the goal of finding current research trends in this area.

  19. Trajetórias e biografias: notas para uma análise bourdieusiana Trajectories and biographies: notes for a Bourdieusian analysis

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Montagner

    2007-06-01

    Full Text Available Nesse artigo, procuramos analisar o uso da metodologia de Pierre Bourdieu, na qual as noções de habitus e campo têm um lugar central, com o objetivo de entender conceitos internos como biografia e trajetória em sua teoria da práxis. Nossa intenção nesse estudo é, além de situar e apontar a relevância da obra de Bourdieu, extrair desses debates possíveis aplicações de sua teoria e propor procedimentos de análise dos materiais biográficos ou histórias de vida quando são usados como um instrumento heurístico.In this article, we seek to examine the use of Pierre Bourdieu's methodology, in which the notions of habitus and field play a central role, in order to understand inner concepts such as biography and trajectory in his theory of praxis. Besides locating and pointing out the relevance of Bourdieu's works, our intention here is to extract from these debates the possible application of his theory and to propose procedures for analysis of biographical materials or life histories when they are used as a heuristic tool.

  20. Synergetics introduction and advanced topics

    CERN Document Server

    Haken, Hermann

    2004-01-01

    This book is an often-requested reprint of two classic texts by H. Haken: "Synergetics. An Introduction" and "Advanced Synergetics". Synergetics, an interdisciplinary research program initiated by H. Haken in 1969, deals with the systematic and methodological approach to the rapidly growing field of complexity. Going well beyond qualitative analogies between complex systems in fields as diverse as physics, chemistry, biology, sociology and economics, Synergetics uses tools from theoretical physics and mathematics to construct an unifying framework within which quantitative descriptions of complex, self-organizing systems can be made. This may well explain the timelessness of H. Haken's original texts on this topic, which are now recognized as landmarks in the field of complex systems. They provide both the beginning graduate student and the seasoned researcher with solid knowledge of the basic concepts and mathematical tools. Moreover, they admirably convey the spirit of the pioneering work by the founder of ...

  1. Scaling up Dynamic Topic Models

    OpenAIRE

    Bhadury, Arnab; Chen, Jianfei; Zhu, Jun; Liu, Shixia

    2016-01-01

    Dynamic topic models (DTMs) are very effective in discovering topics and capturing their evolution trends in time series data. To do posterior inference of DTMs, existing methods are all batch algorithms that scan the full dataset before each update of the model and make inexact variational approximations with mean-field assumptions. Due to a lack of a more scalable inference algorithm, despite the usefulness, DTMs have not captured large topic dynamics. This paper fills this research void, a...

  2. Topic Modeling of Hierarchical Corpora /

    OpenAIRE

    Kim, Do-kyum

    2014-01-01

    The sizes of modern digital libraries have grown beyond our capacity to comprehend manually. Thus we need new tools to help us in organizing and browsing large corpora of text that do not require manually examining each document. To this end, machine learning researchers have developed topic models, statistical learning algorithms for automatic comprehension of large collections of text. Topic models provide both global and local views of a corpus; they discover topics that run through the co...

  3. Industrial Transformation: Research Gaps and Possible Research Topics for IIASA.

    OpenAIRE

    Mulder, P

    1997-01-01

    Industrial transformation has been identified as a priority research topic within the International Human Dimensions Programme on Global Environmental Change (IHDP). This paper looks at the research gaps in the area of Industrial Transformation identified within the framework of IHDP. Furthermore, the paper explores possible research topics for IIASA and discusses possible research questions for the topics of ``Technology'' and ``Consumption''.

  4. Generative Topic Modeling in Image Data Mining and Bioinformatics Studies

    Science.gov (United States)

    Chen, Xin

    2012-01-01

    Probabilistic topic models have been developed for applications in various domains such as text mining, information retrieval and computer vision and bioinformatics domain. In this thesis, we focus on developing novel probabilistic topic models for image mining and bioinformatics studies. Specifically, a probabilistic topic-connection (PTC) model…

  5. Current Topics in Epilepsy Surgery.

    Science.gov (United States)

    Usui, Naotaka

    2016-05-15

    This article reviews the current topics in the field of epilepsy surgery. Each type of epilepsy is associated with a different set of questions and goals. In mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS), postoperative seizure outcome is satisfactory. A recent meta-analysis revealed superior seizure outcome after anterior temporal lobectomy compared with selective amygdalohippocampectomy; in terms of cognitive outcome; however, amygdalohippocampectomy may be beneficial. In temporal lobe epilepsy with normal magnetic resonance imaging (MRI), postoperative seizure outcome is not as favorable as it is in MTLE with HS; further improvement of seizure outcome in these cases is necessary. Focal cortical dysplasia is the most common substrate in intractable neocortical epilepsy, especially in children, as well as in MRI-invisible neocortical epilepsy. Postoperative seizure-free outcome is approximately 60-70%; further diagnostic and therapeutic improvement is required. Regarding diagnostic methodology, an important topic currently under discussion is wideband electroencephalogram (EEG) analysis. Although high-frequency oscillations and ictal direct current shifts are considered important markers of epileptogenic zones, the clinical significance of these findings should be clarified further. Regarding alternatives to surgery, neuromodulation therapy can be an option for patients who are not amenable to resective surgery. In addition to vagus nerve stimulation, intracranial stimulation such as responsive neurostimulation or anterior thalamic stimulation is reported to have a modest seizure suppression effect. Postoperative management such as rehabilitation and antiepileptic drug (AED) management is important. It has been reported that postoperative rehabilitation improves postoperative employment status. Pre- and post-operative comprehensive care is mandatory for postoperative improvement of quality of life. PMID:26984452

  6. «La Perfecta Casada»: from the Model to Representations. Francisca Zorrilla’s Biography, Written by her Husband

    Directory of Open Access Journals (Sweden)

    Margarita TORREMOCHA HERNÁNDEZ

    2016-06-01

    Full Text Available The existence of feminine models for Castilian women in the «postridentine» age is well known. Among these models, it stands out a work written by the Augustinian Fray Luis de León (1583. The great number of editions of the work proves its great success. «La Perfecta Casada» set a prototype of what a married woman should be and was read by many women. Decades after the appearance of this work, another was published in Alcalá (1661, which is not an ideal proposal but the story of a real life: the posthumous biography of Francisca Zorrilla written by her husband, Gabriel Álvarez de Velasco, judge at the «Chancillería» of Santa Fe. Her life, especially her married life, was exemplary. This work focuses on the biographical genre, on the author, on the story of life in its descriptive aspect, as well as on the adjustment to the archetype.

  7. Current topics in radiation measurements

    International Nuclear Information System (INIS)

    Current research topics in radiation measurements will be shown in this presentation. Applications of radiation measurements have grown with the development of radiation sources and new measurement techniques. Recent new developments in this field are briefly introduced. Optical techniques such as lasers and fiber optics, which are widely used in an optical communication field, are successfully applied to radiation measurements. Micro-fabrication techniques and the photolithography technique are indispensable for semiconductor or even gas detectors. Complicated analog signal processing is being simplified by the use of fast computation techniques available in digital chips. Cryogenic X-ray detectors are making a great progress in the energy resolution. Some of the current research topics found in the recent journals and international symposiums are as follows: the development of room temperature semiconductor radiation detectors like CdZnTe and SiC, new signal processing methods such as coplanar grid unipolar charge sensing, medical γ-ray imaging, the development of cryogenic X-ray detectors such as STJs (Superconducting Tunnel Junction) and TES (Transition Edge Sensor) microcalorimeters, micromachined gas proportional counters like MSGC/MGC/GEM, new detection system which requires both the energy and spatial resolutions, the search of longer wavelength scintillators, development of new fast scintillators such as LSO/YAP/LuAP, new digital waveform processing based on fast digitizing technique, etc. Current developments are especially focused on the increase of the information derived from the detector and the improvement in the resolution. One of the other directions of the development is toward the microscopic visualization of the radiation. Such an approach must solve many technological difficulties both in fabrication of the detectors and even in the detection scheme, however, we might proceed to open a new phase of radiation measurements soon. (author)

  8. Topics of Evolutionary Computation 2001

    DEFF Research Database (Denmark)

    Ursem, Rasmus Kjær

    This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem......This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem...

  9. Topics in Banach space theory

    CERN Document Server

    Albiac, Fernando

    2016-01-01

    This text provides the reader with the necessary technical tools and background to reach the frontiers of research without the introduction of too many extraneous concepts. Detailed and accessible proofs are included, as are a variety of exercises and problems. The two new chapters in this second edition are devoted to two topics of much current interest amongst functional analysts: Greedy approximation with respect to bases in Banach spaces and nonlinear geometry of Banach spaces. This new material is intended to present these two directions of research for their intrinsic importance within Banach space theory, and to motivate graduate students interested in learning more about them. This textbook assumes only a basic knowledge of functional analysis, giving the reader a self-contained overview of the ideas and techniques in the development of modern Banach space theory. Special emphasis is placed on the study of the classical Lebesgue spaces Lp (and their sequence space analogues) and spaces of continuous f...

  10. Uranium: War, Energy and the Rock That Shaped the World; Uranium: la biographie

    Energy Technology Data Exchange (ETDEWEB)

    Zoellner, T.

    2009-07-01

    Having traveled extensively through the savannah of Africa, the mountains of Eastern Europe, and the deserts of Utah, the author delves into the complex science, politics and history of uranium, which presents the best and worst of mankind: the capacity for scientific progress and political genius; the capacity for nihilism, exploitation, and terror. Because the author covers so much ground, from the discovery of radioactivity, through the development of the atomic bomb, he does not go into great depth on any one topic. Nonetheless, he paints vivid pictures of uranium's impact, including forced labor in Soviet mines and lucky prospectors who struck it rich in harsh environments, the spread of uranium smuggling, as well as an explanation of why it was absurd to claim that Saddam Hussein was attempting to purchase significant quantities of uranium from Niger. The only shortcoming is the author's omission of the issue of radioactive wastes generated by nuclear power. The author knows well what uranium looks like, why peril pulses in its every atom, and how scientists exploit its nuclear volatility. The drama is found in the weaponry uranium has spawned as demonstrated at Hiroshima and Nagasaki. In pursuit of this raw power, the U.S. let Navajos die extracting needed ore and let southwestern cities sicken beneath clouds from reckless testing. The Soviet Union sentenced tens of thousands to lethal gulag mines. Israel diverted ore through deception on the high seas. Pakistan stole European refining technology. Alive with devious personalities, the author's narrative ultimately exposes the frightening vulnerability of a world with too many sources of a dangerous substance and too little wisdom to control it

  11. THE BIBLICAL EPISODE ABOUT THE THREE TEMPTETIONS OF JESUS AS A TOPIC OF THE DIALOGUE BETWEEN F. M. DOSTOEVSKY AND V. A. ALEKSEEV

    Directory of Open Access Journals (Sweden)

    Babkina T. A.

    2008-11-01

    Full Text Available The article focuses on Dostoevsky's correspondence with the soloist of the Mariinsky Theater orchestra Vasily Alekseevich Alekseev, which appeared as a feedback after the release of "A Writer's Diary".

  12. Evaluating supervised topic models in the presence of OCR errors

    Science.gov (United States)

    Walker, Daniel; Ringger, Eric; Seppi, Kevin

    2013-01-01

    Supervised topic models are promising tools for text analytics that simultaneously model topical patterns in document collections and relationships between those topics and document metadata, such as timestamps. We examine empirically the effect of OCR noise on the ability of supervised topic models to produce high quality output through a series of experiments in which we evaluate three supervised topic models and a naive baseline on synthetic OCR data having various levels of degradation and on real OCR data from two different decades. The evaluation includes experiments with and without feature selection. Our results suggest that supervised topic models are no better, or at least not much better in terms of their robustness to OCR errors, than unsupervised topic models and that feature selection has the mixed result of improving topic quality while harming metadata prediction quality. For users of topic modeling methods on OCR data, supervised topic models do not yet solve the problem of finding better topics than the original unsupervised topic models.

  13. Nanoparticles - A paradigm for topical drug delivery

    Directory of Open Access Journals (Sweden)

    Yogesh S Chaudhari

    2012-01-01

    Full Text Available Topical drug delivery is still a challenge due to the difficulties in controlling the active pharmaceutical ingredient (API fate within the skin. Due to the safety of the component material and controlled release abilities, nanoparticles offer an excellent opportunity for the rational delivery of drugs to the desired target site and hence these carrier systems are effectively used for topical delivery of variety of active principles for both pharmaceutical as well as cosmetic purposes. Recently, solid lipid nanoparticles (SLNs have shown a great potential as carriers for topical administration of active substances, principally owing to the possible targeting effect and controlled release in different skin strata. Also, nanostructured lipid carriers (NLCs are a new type of topical delivery system offering improved performance in terms of drug loading and long-term stability with the ability to form highly concentrated dispersions. Another invention in the field of topical drug delivery is the use of micellar nanoparticles (MNPs that offer a potentially fast and inexpensive pharmaceutical development model by using drugs already proven safe and effective to create new proprietary formulations. These novel drug delivery systems have gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers.

  14. The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model for topical anti-proliferative drugs

    DEFF Research Database (Denmark)

    Jensen, Mette; Groth, L.; Holmer, G.;

    2002-01-01

    The objective of this study was to establish essential fatty acid deficiency (EFAD) in hairless rats and investigate the potential of this model as a psoriasis screening model by testing the effects of calcipotriol and dithranol on differentiation and proliferation in the epidermis. Hairless rats...

  15. KEY TOPICS IN SPORTS MEDICINE

    Directory of Open Access Journals (Sweden)

    Amir Ali Narvani

    2006-12-01

    Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

  16. A Problematic Family Reunion of a Chinese-American in China: Issues of Face Abstract: As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses thr...%ract: As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses three critical incidents based on two face theories proposed by Brown and Levinson ...

    Institute of Scientific and Technical Information of China (English)

    曹凤琴

    2012-01-01

    As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses three critical incidents based on two face theories proposed by Brown and Levinson (1987) and Ting-Toomey and Kurogi(1998) respectively. Lastly, by focusing on the relationship between the rapport-threatening behavior and the face, this paper intends to cultivate our awareness of face and highlight the harmonious interpersonal relationship between different cultures.

  17. TOPICAL REVIEW: FPA-based infrared thermography as applied to the study of cutaneous perspiration and stimulated vascular response in humans

    Science.gov (United States)

    Vainer, Boris G.

    2005-12-01

    This review gives an overview of focal plane array (FPA)-based infrared (IR) thermography as a powerful research method in the field of physiology and medicine. Comparison of the gained results with the data previously obtained by other authors with other research tools is given. Outer thermoregulatory manifestations displayed by the human organism subjected to whole-body heating (sauna bath) and physical loads (exercise bicycling) are quantitatively analysed. Some details of human body emotional sweating (psycho-physiological effect) are reported. Particular attention is paid to studying active sweat glands as individual objects. All experimental data were obtained with the help of a high-sensitivity (0.03 °C) fast 128 × 128 InAs IR detector-based thermal imaging system operating in the short-wave spectral region (2.5 to 3 µm) and perfectly suiting medical purposes. It is shown that IR thermography makes it possible to overcome limitations inherent to contact measuring means that were traditionally used before in thermal studies. It is also shown that heterogeneous thermograms displayed by organisms with disturbed inner equilibrium can be quantitatively analysed in terms of statistical parameters of related surface-temperature histograms, such as the mean temperature and the standard deviation of temperature (SDT). The increase and the decrease in SDT turned out to be typical of prolonged physical load and subsequent relaxation, and of external whole-body heating, respectively. Explanation of this result based on a hypothesis advanced within the context of the doctrine of human-organism evolution is given. Skin-temperature distribution function accompanying the relaxed organism in normality was found to closely resemble normal-distribution function. Symmetry break down and variation of the shape of this characteristic may serve as an indicator of homeostasis shift and can be used as a quantitative criterion for the latter. A new phenomenon, stable punctate

  18. Scopus vs WOS as scientific evaluation tools:A comparative analysis based on a testing sample search on the topic of electric vehicles

    Institute of Scientific and Technical Information of China (English)

    WANG; Na; PAN; Yuntao; MA; Zheng; WU; Yishan

    2010-01-01

    Based on a bibliometric analysis in combination with other information analysis methods,this paper compares the different evaluation results on the subject of"electric vehicles"drawn from Web of Science(WOS)and from Scopus.We came to the following conclusions after a careful comparison of these two databases.Firstly,both WOS and Scopus would provide some valid and unique evaluation indicators.Secondly,they showed similar results in terms of evaluating research performance of countries and research organizations involved in the targeted subject fields.In fact,both databases are good for discovering the research trend in general at the macroscopic level.Lastly,we ought to take the disciplinary characteristics,the extent of journal inclusion and resource selection criteria as well as inevitable data errors into full account in making recommendations to policy decision-makers.

  19. Maps on the basis of the Arts & Humanities Citation Index: The journals Leonardo and Art Journal versus "Digital Humanities" as a topic

    OpenAIRE

    Leydesdorff, Loet; Salah, Alkim Almila Akdag

    2009-01-01

    The possibilities of using the Arts & Humanities Citation Index (A&HCI) for journal mapping have not been sufficiently recognized because of the absence of a Journal Citations Report (JCR) for this database. A quasi-JCR for the A&HCI (2008) was constructed from the data contained in the Web-of-Science and is used for the evaluation of two journals as examples: Leonardo and Art Journal. The maps on the basis of the aggregated journal-journal citations within this domain can be compared with ma...

  20. Character Education. What Works Clearinghouse Topic Report

    Science.gov (United States)

    What Works Clearinghouse, 2007

    2007-01-01

    Character education is a fairly new and rapidly evolving topic for curriculum interventions. Character can encompass such moral and ethical values as respect, fairness, and caring -- as well as responsibility, trustworthiness, and citizenship. It can refer to the demonstration of these values in behavior, reasoning, and emotions. The What Works…

  1. Testing of Continuous Sampling Air-ICP and Mercury Systems as Continuous Emission Monitors at the Diagnostic Instrumentation and Analysis Laboratory; TOPICAL

    International Nuclear Information System (INIS)

    This report has been prepared to document the performance of the continuous sampling reduced-pressure air-ICP-AES (inductively coupled plasma-atomic emission spectroscopy) and mercury-monitor systems developed by Ames Laboratory for use as continuous emission monitors (CEM). This work was funded by the U. S. Department of Energy, Office of Environmental Management, Office of Science and Technology, through the Mixed Waste Focus Area. The purpose of the project is to develop instrumentation and methods for spectroscopic field monitoring applications. During FY00 this included continued work on the development of the continuous sample introduction system and the multi-frequency AOTF-echelle spectrometer, used in conjunction with the reduced-pressure air-ICP-AES system as a multi-metal CEM. The assembly, development, and testing of an echelle spectrometer system for the detection of mercury (Hg) by atomic absorption was also completed during FY00. The continuous sampling system and the multi-metal air-ICP and mercury-monitor CEM systems were tested at Mississippi State University at the Diagnostic Instrumentation and Analysis Laboratory (DIAL) at the end of FY00. This report describes the characteristics and performance of these systems, and the results of the field tests performed at DIAL

  2. Topics in Galois theory

    CERN Document Server

    Serre, Jean-Pierre

    2007-01-01

    This book is based on a course given by the author at Harvard University in the fall semester of 1988. The course focused on the inverse problem of Galois Theory: the construction of field extensions having a given finite group as Galois group. In the first part of the book, classical methods and results, such as the Scholz and Reichardt construction for p-groups, p != 2, as well as Hilbert's irreducibility theorem and the large sieve inequality, are presented. The second half is devoted to rationality and rigidity criteria and their application in realizing certain groups as Galois groups of

  3. The RING for gypsy moth control: Topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide.

    Science.gov (United States)

    Oberemok, Volodymyr V; Laikova, Kateryna V; Zaitsev, Aleksei S; Gushchin, Vladimir A; Skorokhod, Oleksii A

    2016-07-01

    Numerous studies suggest a cellular origin for the Lymantria dispar multicapsid nuclear polyhedrosis virus (LdMNPV) anti-apoptosis genes IAPs, thus opening a possibility to use the fragments of these genes for modulation of host metabolism. We report here the strong insecticidal and metabolic effect of single-stranded antisense DNA fragment from RING (really interesting new gene) domain of gypsy moth LdMNPV IAP-3 gene: specifically, on reduction of biomass (by 35%) and survival of L. dispar caterpillars. The treatment with this DNA fragment leads to a significantly higher mortality rates of female insects (1.7 fold) accompanied with the signs of apoptosis. Additionally, we show increased expression of host IAP-1, caspase-4 and gelsolin genes in eggs laid by survived females treated with RING DNA fragment accompanied with calcium and magnesium imbalance, indicating that the strong stress reactions and metabolic effects are not confined to treated insects but likely led to apoptosis in eggs too. The proposed new approach for insect pest management, which can be considered as advancement of "microbial pesticides", is based on the application of the specific virus DNA, exploiting the knowledge about virus-pest interactions and putting it to the benefit of mankind. PMID:27265824

  4. Selected topics on Hadrons in Nuclei

    CERN Document Server

    Oset, E; Hernandez, E; Ramos, A; Magas, V K; Yamagata-Sekihara, J; Hirenzaki, S; Gamermann, D; Molina, R; Tolos, L; Roca, L

    2011-01-01

    In this talk we report on selected topics on hadrons in nuclei. The first topic is the renormalization of the width of the $\\Lambda(1520)$ in a nuclear medium. This is followed by a short update of the situation of the $\\omega$ in the medium. The investigation of the properties of $\\bar{K}$ in the nuclear medium from the study of the $(K_{flight},p)$ reaction is also addressed, as well as properties of X,Y,Z charmed and hidden charm resonances in a nuclear medium. Finally we address the novel issue of multimeson states.

  5. Learning Topic Models by Belief Propagation

    CERN Document Server

    Zeng, Jia; Liu, Jiming

    2011-01-01

    Latent Dirichlet allocation (LDA) is an important class of hierarchical Bayesian models for probabilistic topic modeling, which attracts worldwide interests and touches many important applications in text mining, computer vision and computational biology. This paper proposes a novel tree-structured factor graph representation for LDA within the Markov random field (MRF) framework, which enables the classic belief propagation (BP) algorithm for exact inference and parameter estimation. Although two commonly-used approximation inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great successes in learning LDA, the proposed BP is competitive in both speed and accuracy validated by encouraging experimental results on four large-scale document data sets. Furthermore, the BP algorithm has the potential to become a generic learning scheme for variants of LDA-based topic models. To this end, we show how to learn two typical variants of LDA-based topic models, such as autho...

  6. Advanced topics in biometrics

    CERN Document Server

    Li, Haizhou; Toh, Kar-Ann

    2011-01-01

    Biometrics is the study of methods for uniquely recognizing humans based on one or more intrinsic physical or behavioral traits. After decades of research activities, biometrics, as a recognized scientific discipline, has advanced considerably both in practical technology and theoretical discovery to meet the increasing need of biometric deployments. In this book, the editors provide both a concise and accessible introduction to the field as well as a detailed coverage on the unique research problems with their solutions in a wide spectrum of biometrics research ranging from voice, face, finge

  7. Topics in general topology

    CERN Document Server

    Morita, K

    1989-01-01

    Being an advanced account of certain aspects of general topology, the primary purpose of this volume is to provide the reader with an overview of recent developments.The papers cover basic fields such as metrization and extension of maps, as well as newly-developed fields like categorical topology and topological dynamics. Each chapter may be read independently of the others, with a few exceptions. It is assumed that the reader has some knowledge of set theory, algebra, analysis and basic general topology.

  8. Emerging topics in FXTAS

    DEFF Research Database (Denmark)

    Hall, Deborah A; Birch, Rachael C; Anheim, Mathieu;

    2014-01-01

    This paper summarizes key emerging issues in fragile X-associated tremor/ataxia syndrome (FXTAS) as presented at the First International Conference on the FMR1 Premutation: Basic Mechanisms & Clinical Involvement in 2013....

  9. Nonsteroidal Topical Immunomodulators in Allergology and Dermatology

    Science.gov (United States)

    Jovanović, Marina; Golušin, Zoran

    2016-01-01

    The purpose of this study was to review currently available literature data concerning pathomechanisms of action, indications, treatment efficacy, as well as side effects of nonsteroidal immunomodulators used in dermatology, primarily for the treatment of allergic dermatoses. MEDLINE search was undertaken using the key words “Topical Immunomodulators, Dermatology and Allergy”. Full articles, and nothing but full articles, were used. PMID:27144167

  10. Water: A Topic for All Sciences

    Science.gov (United States)

    Davies, Malonne I.; Seimears, C. Matt

    2008-01-01

    The authors illustrate an effective lesson-planning technique known as unpacking for the broad topic of water. Interconnections among science disciplines are shown for numerous possible subtopics. Two lesson sets are included, the first dealing with properties of water and the second dealing with water as a resource. (Contains 1 table and 4…

  11. Health Topic XML File Description

    Science.gov (United States)

    ... XML File Description: MedlinePlus URL of this page: https://www.nlm.nih.gov/medlineplus/xmldescription.html Health ... corresponding health topic page on MedlinePlus. Example: url="https://www.nlm.nih.gov/medlineplus/abdominalpain.html" Use ...

  12. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    The collection of abstracts on selected topics in nuclear structure are given. Special attention pays to collective excitations and high-spin states of nuclei, giant resonance structure, nuclear reaction mechanisms and so on

  13. Topics of Bioengineering in Wikipedia

    Directory of Open Access Journals (Sweden)

    Vassia Atanassova

    2009-10-01

    Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

  14. Do scientists trace hot topics?

    OpenAIRE

    Tian Wei; Menghui Li; Chensheng Wu; Xiao-Yong Yan; Ying Fan; Zengru Di; Jinshan Wu

    2013-01-01

    Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries,...

  15. Key Topics in Sports Medicine

    OpenAIRE

    Amir Ali Narvani; Panagiotis Thomas; Burce Lynn

    2006-01-01

    Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

  16. Current topics in photovoltaics

    International Nuclear Information System (INIS)

    This book contains papers on current research in photovoltaics. Areas include: outdoor spectral odor radiation variations and their relationship to photovoltaic device performance, numerical modeling for analysis and design of solar cells, radiation damage mechanisms in GaAs and Si solar cells, and health and safety issues in the manufacturing of photovoltaic cells

  17. Topics in probability

    CERN Document Server

    Prabhu, Narahari

    2011-01-01

    Recent research in probability has been concerned with applications such as data mining and finance models. Some aspects of the foundations of probability theory have receded into the background. Yet, these aspects are very important and have to be brought back into prominence.

  18. [Current topics in pediatric nutrition].

    Science.gov (United States)

    Morali, A; Vidailhet, M

    2002-07-01

    As main current topics in pediatric nutrition we have considered the results of the continuing research on the long term consequences of fetal malnutrition and intra-uterine growth retardation with the concept of metabolic imprinting leading to chronic disease in adulthood, the progresses of knowledge in the fields of iron metabolism and regulatory mechanisms of satiety, hunger and energetic balance, a better determination of recommended docosahexanoic and arachidonic acids intake in the first months of life for premature and term infants, and the studies on probiotics and prebiotics utilization for preventive and curative purposes. The concerns about vitamin D insufficiency in France have markedly decreased with the generalization ten years ago of cholecalciferol supplementation of infant formula, and more recently the authorization of dairy products supplementation. On the contrary the problem of iron deficiency in young children remains, as well as two major nutritional concerns: the very low percentage of breast-fed infants and the dramatic increase of childhood obesity which affects presently 14% of 10 year old children versus 5% in 1980. PMID:12162162

  19. Kenneth S. Norris: Naturalist, Cetologist & Conservationist, 1924-1998: An Oral History Biography

    OpenAIRE

    Reti, Irene H.

    1999-01-01

    The Regional History Project conducted a series of interviews with Kenneth S. Norris, UCSC Professor of Natural History Emeritus, in the spring and summer of 1998. Halfway through the interviews, Norris, who had been in poor health, was hospitalized unexpectedly and died on August 16, 1998. Rather than publish an incomplete set of his edited interviews, the project was reconceived. We interviewed a group of his colleagues and former students who could discuss many of the topics the interviewe...

  20. Topics In Quantum Geometry

    CERN Document Server

    Raugas, M V

    2001-01-01

    In this work, we investigate different features of the quantum geometry associated to string theory. In chapter one, we use the language of quiver theory to determine the toric part of the classical moduli space of D-branes on a nonabelian Calabi-Yau threefold singularity and see that it admits topology-changing transitions. In chapter two, we determine the worldvolume field theories of D3-branes transverse to Calabi-Yau cones over singular Fano surfaces, which can be realized as partial resolutions of an orbifold of complex three-space by a discrete group. A mismatch between the isometries of the complex line bundle over the Fano surfaces and the discrete symmetries of the effective superpotential is found. In chapter three, we investigate the quantum volume of D-branes wrapped around cycles of various dimension in Calabi-Yau fourfolds and fivefolds. We consider the cases of the sextic and heptic hypersurface Calabi-Yau manifolds, as well as one example in weighted projective space, and find expressions for...

  1. Topics in Supergravity Phenomenology

    CERN Document Server

    Dhuria, Mansi

    2014-01-01

    In the first part of the review article, we discuss the possibility of realizing "mu-split-like SUSY" scenario from a phenomenological model, which we show could be realizable locally as the large volume limit of a type IIB Swiss-Cheese Calabi-Yau orientifold involving a mobile space-time filling D3-brane localized at a nearly special Lagrangian three-cycle embedded in the "big" divisor and multiple fluxed stacks of space-time filling D7-branes wrapping the same "big" divisor. We show that the mass of one of the Higgs doublets can be produced to be of the order of 125 GeV whereas other Higgs as well as higgsino mass parameter to be very heavy- the "mu-split-like SUSY" scenario. Then we discuss the role of the heavy squarks/sleptons and the light Higgs in (i) obtaining long-lived gluinos (ii) in verifying that the NLSPs (squarks/sleptons/neutralino) decay into the LSP (gravitino) respects the BBN constraints with the lifetime of the LSP (gravitino) coming out to be of the order or larger than the age of the un...

  2. A Discourse Perspective of Topic-prominence in Chinese EFL Learners’ Interlanguage

    OpenAIRE

    Shaopeng Li; Lianrui Yang

    2014-01-01

    The present study aims to investigate the general characteristics of topic-prominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from the discourse perspective. We have selected as the research target “topic chain” which is the main topic-prominent structure in Chinese discourse and “zero anaphora” which is the most common topic anaphor of topic chain. Topic structures mainly appear in Chinese discourse in the...

  3. APT accelerator. Topical report

    International Nuclear Information System (INIS)

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation's stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century

  4. APT accelerator. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, G.; Rusthoi, D. [comp.] [ed.

    1995-03-01

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation`s stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century.

  5. TOPICAL REVIEW: Biopolymeric nanoparticles

    Science.gov (United States)

    Sundar, Sushmitha; Kundu, Joydip; Kundu, Subhas C.

    2010-02-01

    This review on nanoparticles highlights the various biopolymers (proteins and polysaccharides) which have recently revolutionized the world of biocompatible and degradable natural biological materials. The methods of their fabrication, including emulsification, desolvation, coacervation and electrospray drying are described. The characterization of different parameters for a given nanoparticle, such as particle size, surface charge, morphology, stability, structure, cellular uptake, cytotoxicity, drug loading and drug release, is outlined together with the relevant measurement techniques. Applications in the fields of medicine and biotechnology are discussed along with a promising future scope.

  6. Topics in superstring theory

    International Nuclear Information System (INIS)

    The author discusses two specific issues in superstring theory as follows: regularization of open superstring from oriented closed surface and worldsheet supersymmetry. Regarding the first issue, the author discusses a technical issue occurring in the open superstring which allows introduction of a multiplicative Chan-Paton factor. For O(N) groups the adjoint representation is the antisymmetric part of N x N and this simple property is lacking in the exceptional groups. The author discusses how for superstrings there are two relevant kinds of supersymmetry: spacetime supersymmetry in d = 10 spacetime dimensions and worldsheet supersymmetry in d = 2 worldsheet dimensions. Until a few months ago, all known superstrings possessed both: at least N = 1 spacetime supersymmetry and at lest (1,0) worldsheet supersymmetry. Recently, however, an 0(16) x 0(16) superstring was proposed with no spacetime supersymmetry; the model has infrared problems on flat M10 but these problems might be cured by compactification. This motivates one to study the restrictions on the six-dimensional compact manifold for the case without spacetime supersymmetry. The author finds that (2,2) worldsheet supersymmetry and quantum conformal invariance of the two-dimensional field theory lead to equally strong restrictions as does the assumption of preserving a spacetime supersymmetry

  7. Visual Structure Language; TOPICAL

    International Nuclear Information System (INIS)

    In this paper we describe a new language, Visual Structure Language (VSL), designed to describe the structure of a program and explain its pieces. This new language is built on top of a general-purpose language, such as C. The language consists of three extensions: explanations, nesting, and arcs. Explanations are comments explicitly associated with code segments. These explanations can be nested. And arcs can be inserted between explanations to show data- or control-flow. The value of VSL is that it enables a developer to better control a code. The developer can represent the structure via nested explanations, using arcs to indicate the flow of data and control. The explanations provide a ''second opinion'' about the code so that at any level, the developer can confirm that the code operates as it is intended to do. We believe that VSL enables a programmer to use in a computer language the same model-a hierarchy of components-that they use in their heads when they conceptualize systems

  8. Mapping the evolution of research topics using ATM and SNA

    Institute of Scientific and Technical Information of China (English)

    Chunlei; YE

    2014-01-01

    Purpose:This paper introduces an analysis framework for tracking the evolution of research topics at the selected topics level,covering a research topic’s evolution trend,evolution path and its content changes over time.Design/methodology/approach:After the topics were recovered by the author-topic model,we first built the keyword-topic co-occurrence network to track the dynamics of topic trends.Then a single-mode network was constructed with each node representing a topic and edge indicating the relationship between topics.It was used to illustrate the evolution path and content changes of research topics.A case study was conducted on the digital library research in China to verify the effectiveness of the analysis framework.Findings:The experimental results show that this analysis framework can be used to track evolution of research topics at a micro level and using social network analysis method can help understand research topics’evolution paths and content changes with the passage of time.Research limitations:Using the analysis framework will produce limited results when examining unstructured data such as social media data.In addition,the effectiveness of the framework introduced in this paper needs to be verified with more research topics in information science and in more scientific fields.Practical implications:This analysis framework can help scholars and researchers map research topics’evolution process and gain insights into how a field’s topics have evolved over time.Originality/value:Tbe analysis framework used in this study can help reveal more micro evolution details.The index to measure topic association strength defined in this paper reflects both similarity and dissimilarity between topics,which belps better understand research topics’evolution paths and content changes.

  9. Topics in quantum gravity

    International Nuclear Information System (INIS)

    Quantum gravity is an attempt to unify general relativity with quantum mechanics which are the two highly successful fundamental theories of theoretical physics. The main difficulty in this unification arises from the fact that, while general relativity describes gravity as a macroscopic geometrical theory, quantum mechanics explains microscopic phenomena. As a further complication, not only do both theories describe different scales but also their philosophical ramifications and the mathematics used to describe them differ in a dramatic way. Consequently, one possible starting point of an attempt at a unification is quantum mechanics, i.e. particle physics, and try to incorporate gravitation. This pathway has been chosen by particle physicists which led to string theory. On the other hand, loop quantum gravity (LQG) chooses the other possibility, i.e. it takes the geometrical aspects of gravity seriously and quantizes geometry. The first part of this thesis deals with a generalization of loop quantum cosmology (LQC) to toroidal topologies. LQC is a quantization of homogenous solutions of Einstein's field equations using tools from LQG. First the general concepts of closed topologies is introduced with special emphasis on Thurston's theorem and its consequences. It is shown that new degrees of freedom called Teichmueller parameters come into play and their dynamics can be described by a Hamiltonian. Several numerical solutions for a toroidal universe are presented and discussed. Following the guidelines of LQG this dynamics are rewritten using the Ashtekar variables and numerical solutions are shown. However, in order to find a suitable Hilbert space a canonical transformation must be performed. On the other hand this transformation makes the quantization of geometrical quantities less tractable such that two different ways are presented. It is shown that in both cases the spectrum of such geometrical operators depends on the initial value problem. Furthermore, we

  10. Topics in quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Lamon, Raphael

    2010-06-29

    Quantum gravity is an attempt to unify general relativity with quantum mechanics which are the two highly successful fundamental theories of theoretical physics. The main difficulty in this unification arises from the fact that, while general relativity describes gravity as a macroscopic geometrical theory, quantum mechanics explains microscopic phenomena. As a further complication, not only do both theories describe different scales but also their philosophical ramifications and the mathematics used to describe them differ in a dramatic way. Consequently, one possible starting point of an attempt at a unification is quantum mechanics, i.e. particle physics, and try to incorporate gravitation. This pathway has been chosen by particle physicists which led to string theory. On the other hand, loop quantum gravity (LQG) chooses the other possibility, i.e. it takes the geometrical aspects of gravity seriously and quantizes geometry. The first part of this thesis deals with a generalization of loop quantum cosmology (LQC) to toroidal topologies. LQC is a quantization of homogenous solutions of Einstein's field equations using tools from LQG. First the general concepts of closed topologies is introduced with special emphasis on Thurston's theorem and its consequences. It is shown that new degrees of freedom called Teichmueller parameters come into play and their dynamics can be described by a Hamiltonian. Several numerical solutions for a toroidal universe are presented and discussed. Following the guidelines of LQG this dynamics are rewritten using the Ashtekar variables and numerical solutions are shown. However, in order to find a suitable Hilbert space a canonical transformation must be performed. On the other hand this transformation makes the quantization of geometrical quantities less tractable such that two different ways are presented. It is shown that in both cases the spectrum of such geometrical operators depends on the initial value problem

  11. Two Topics In String Theory

    CERN Document Server

    Cheung, Y E

    2000-01-01

    We study two topics in string theory: consistency of D- branes and their intersections in topologically nontrivial background, and Noncommutative Geometry and “Little String Theories.” When a D-brane wraps around a cycle of a curved manifold, the nontrivial topology of its normal bundle can induce chiral asymmetry in its worldvolume theory. We obtain the general form of the resulting anomalies for D-branes and their intersections. They are not cancelled among themselves, and the standard inflow mechanism does not apply at first sight because of their apparent lack of factorizability and the apparent vanishing of the corresponding inflow. We show, however, that after taking into consideration the effects of the twisting of the normal bundles, the anomalies can be transformed into factorized forms and precisely cancelled by finite inflow from the Chern-Simons actions for the D-branes as long as the latter are well defined. Such twisting of the normal bundle is shown to induce Ramond-Ramond c...

  12. The Virtual Robotics Laboratory; TOPICAL

    International Nuclear Information System (INIS)

    The growth of the Internet has provided a unique opportunity to expand research collaborations between industry, universities, and the national laboratories. The Virtual Robotics Laboratory (VRL) is an innovative program at Oak Ridge National Laboratory (ORNL) that is focusing on the issues related to collaborative research through controlled access of laboratory equipment using the World Wide Web. The VRL will provide different levels of access to selected ORNL laboratory secondary education programs. In the past, the ORNL Robotics and Process Systems Division has developed state-of-the-art robotic systems for the Army, NASA, Department of Energy, Department of Defense, as well as many other clients. After proof of concept, many of these systems sit dormant in the laboratories. This is not out of completion of all possible research topics. but from completion of contracts and generation of new programs. In the past, a number of visiting professors have used this equipment for their own research. However, this requires that the professor, and possibly his/her students, spend extended periods at the laboratory facility. In addition, only a very exclusive group of faculty can gain access to the laboratory and hardware. The VRL is a tool that enables extended collaborative efforts without regard to geographic limitations

  13. Organic solvent topical report

    Energy Technology Data Exchange (ETDEWEB)

    COWLEY, W.L.

    1999-05-13

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an organic solvent fire is within risk evaluation guidelines. This report updates information contained in Analysis of Consequences of Postulated Solvent Fires in Hanford Site Waste Tanks. WHC-SD-WM-CN-032. Rev. 0A (Cowley et al. 1996). However, this document will not replace Cowley et al (1996) as the primary reference for the Basis for Interim Operation (BIO) until the recently submitted BIO amendment (Hanson 1999) is approved by the US Department of Energy. This conclusion depends on the use of controls for preventing vehicle fuel fires and for limiting the use of flame cutting in areas where hot metal can fall on the waste surface.The required controls are given in the Tank Waste Remediation System Technical Safety Requirements (Noorani 1997b). This is a significant change from the conclusions presented in Revision 0 of this report. Revision 0 of this calcnote concluded that some organic solvent fire scenarios exceeded risk evaluation guidelines, even with controls imposed.

  14. Hot Topic Talk 4

    Science.gov (United States)

    Hosten, Onur

    2016-05-01

    I will focus on our experiments with cold atoms highlighting some of the most recent developments in the prospect of using quantum entanglement to improve the precision of atomic and optical sensors. The first part of the talk will describe the generation of 20 dB spin-squeezed states of half a million 87Rb atoms inside of an optical cavity. The second part will describe the experimental demonstration of a new concept we call quantum phase magnification. The demonstrated 20 dB squeezing enables a 100-fold reduction in averaging time or a 100-fold reduction in atom numbers to achieve a given sensing precision. As part of this work we show an atomic clock operating 10 dB beyond the classical limit. Some of the states prepared in these experiments possess in excess of 680 atom entanglement. The quantum phase magnification experiment shows that detection noise levels below the standard quantum limit is in fact not a requirement to realize the benefits of the intrinsic sensitivity provided by exotic quantum states. Here, optical cavity-aided effective interactions between atoms magnify signals to-be-measured to levels that can easily be detected with a rather inefficient fluorescence imaging system. The method relaxes stringent detection requirements which have been the main bottleneck in quantum metrology experiments, and can also be implemented in physical platforms other than cold atom-cavity systems.

  15. Organic solvent topical report

    International Nuclear Information System (INIS)

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an organic solvent fire is within risk evaluation guidelines. This report updates information contained in Analysis of Consequences of Postulated Solvent Fires in Hanford Site Waste Tanks. WHC-SD-WM-CN-032. Rev. 0A (Cowley et al. 1996). However, this document will not replace Cowley et al (1996) as the primary reference for the Basis for Interim Operation (BIO) until the recently submitted BIO amendment (Hanson 1999) is approved by the US Department of Energy. This conclusion depends on the use of controls for preventing vehicle fuel fires and for limiting the use of flame cutting in areas where hot metal can fall on the waste surface.The required controls are given in the Tank Waste Remediation System Technical Safety Requirements (Noorani 1997b). This is a significant change from the conclusions presented in Revision 0 of this report. Revision 0 of this calcnote concluded that some organic solvent fire scenarios exceeded risk evaluation guidelines, even with controls imposed

  16. Risk Management Plan; TOPICAL

    International Nuclear Information System (INIS)

    The purpose of this Risk Management Plan (RMP) is to establish the concept and define the process to assure that National Nuclear Security Administration Nevada Operations Office Environmental Management (NNSA/NV EM) programs and projects incorporate appropriate, efficient, cost-effective measures to mitigate the impact of program-and/or project-related risks. In addition, it describes the roles and responsibilities of program personnel in performing the risk management functions, and defines reporting and tracking requirements for risk-related information. The product of this risk analysis will be a risk analysis report listing the various risks with their classification, mitigation and handling strategies, impact on cost and schedule, and action items. The risk management process will identify potential risk sources; assess individual risks and impacts on performance, cost, and schedule; evaluate alternative approaches to mitigate high and moderate risks; develop action plans to handle individual risks; and interface risks with other programs and/or projects. Risk management and risk assessment will be consistent with DOE Orders 430.1 and 413.3 and their associated guidance documentation. The RMP will remain valid for the life cycle of the program and/or projects and will be under configuration control with revisions to be conducted as required and approved

  17. Topical Structure in Arabic-English Interlanguage.

    Science.gov (United States)

    Fakhri, Ahmed

    A study compared the topical structure (TS) of Arabic and English in order to determine whether Arab learners of English as a Second Language (ESL) transfer potential differences between Arabic and English in their English writing, or whether they use an altogether different TS indicative of developmental factors. Four sets of data were compared…

  18. Topics in Collider Physics

    International Nuclear Information System (INIS)

    It is an exciting time for high energy physics. Several experiments are currently exploring uncharted terrain; the next generation of colliders will begin operation in the coming decade. These experiments will together help us understand some of the most puzzling issues in particle physics: the mechanism of electroweak symmetry breaking and the generation of flavor physics. It is clear that the primary goal of theoretical particle physics in the near future is to support and guide this experimental program. These tasks can be accomplished in two ways: by developing experimental signatures for new models which address outstanding problems, and by improving Standard Model predictions for precision observables. We present here several results which advance both of these goals. We begin with a study of non-commutative field theories. It has been suggested that TeV-scale non-commutativity could explain the origin of CP violation in the SM. We identify several distinct signatures of non-commutativity in high energy processes. We also demonstrate the one-loop quantum consistency of a simple spontaneously broken non-commutative U(1) theory; this result is an important preface to any attempt to embed the SM within a non-commutative framework. We then investigate the phenomenology of extra-dimensional theories, which have been suggested recently as solutions to the hierarchy problem of particle physics. We first examine the implications of allowing SM fields to propagate in the full five-dimensional spacetime of the Randall-Sundrum model, which solves the hierarchy problem via an exponential ''warping'' of the Planck scale induced by a five-dimensional anti de-Sitter geometry. In an alternative extra-dimensional theory, in which all SM fields are permitted to propagate in flat extra dimensions, we show that properties of the Higgs boson are significantly modified. Finally, we discuss the next-to-next-to leading order QCD corrections to the dilepton rapidity distribution in

  19. Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit

    Science.gov (United States)

    Nejabat, Mahmood; Yaqubi, Nafiseh; Khosravi, Amir; Zomorodian, Kamiar; Ashraf, Mohammad Javad; Salouti, Ramin

    2016-01-01

    Purpose. Evaluating the therapeutic effect of topical and intrastromal voriconazole and topical natamycin on Fusarium keratitis. Methods. 24 rabbits were selected. The stroma of their corneas was inoculated with suspension of Fusarium solani species complex. Seven days after injection they were divided into 4 groups randomly: the first group was treated with topical voriconazole (TV) 1% for one week, the second one with one-time intrastromal injection of voriconazole (ISV) 50 microgram/0.1 mL, and the third group with topical gel of natamycin (TN) for one week, and the last one did not receive any antifungal treatment. Finally the eyes were enucleated and sclerocorneal buttons were sent for histological and microbiological examinations. Results. After treatment the ISV group and TN group showed significantly lower clinical score and colony forming units than the control group (P = 0.040 and P = 0.026, resp.), but there was statistically no significant difference between control and TV groups (P = 0.249) or between ISV and TN groups (P = 0.665). In pathological evaluation, fewer chronic inflammations were reported in 2 of the 3 buttons from TV group and 3 of the 3 buttons from ISV and TN groups in comparison with the control group. Conclusion. Intrastromal injection of voriconazole seems to be effective in treatment of Fusarium keratitis as much as topical natamycin and these are more effective than topical voriconazole.

  20. Topics on electricity trade

    International Nuclear Information System (INIS)

    being unable to fulfil the commitments made on the spot market. The disclosed cost of using the regulating power market is a quadratic function of the amount of regulation. This asymmetric cost may encourage bidders with fluctuating production to be more strategic in their way of bidding on the spot market. By using such strategies the extra costs (for e.g. wind power) needed to counter unpredictable fluctuations may be limited. The fourth paper applies the findings in the previous paper to show how a supplier with a 'controllable' production will make strategic bids on the power exchange - in this case a heat pump. The fifth paper discusses the design of the regulating power market and what the choice of design means for suppliers with fluctuating production, e.g. wind turbines. It is found that not only does the accuracy of the wind prediction influence the use of the power exchange, but the structure of the power exchange itself may also play an important role. Several studies of the northern European electricity liberalisation have concluded that developments of a liberalised electricity market and cross border trade can be of benefit for the consumers and bring along a global environmental improvement. All these studies have assumed that a perfect competitive electricity market can be obtained. A number of imperfections, which inevitably will arise, have not been taken into account, - at least in the transition period. These imperfections can be technical, economic or tradition-bound, but may have political characteristics as well. The sixth paper in this thesis surveys those market imperfections which are most likely to appear. Market imperfections can, for example, have structural or political characteristics that imply non-optimal competitive behaviour, e.g., the means to achieve political goals may hinder the desirable effects of the liberalisation. This can, for example, come from the creation of suitable arrangements for survival and enlargement of renewable

  1. Topics on electricity trade

    Energy Technology Data Exchange (ETDEWEB)

    Skytte, K.

    2001-07-01

    being unable to fulfil the commitments made on the spot market. The disclosed cost of using the regulating power market is a quadratic function of the amount of regulation. This asymmetric cost may encourage bidders with fluctuating production to be more strategic in their way of bidding on the spot market. By using such strategies the extra costs (for e.g. wind power) needed to counter unpredictable fluctuations may be limited. The fourth paper applies the findings in the previous paper to show how a supplier with a 'controllable' production will make strategic bids on the power exchange - in this case a heat pump. The fifth paper discusses the design of the regulating power market and what the choice of design means for suppliers with fluctuating production, e.g. wind turbines. It is found that not only does the accuracy of the wind prediction influence the use of the power exchange, but the structure of the power exchange itself may also play an important role. Several studies of the northern European electricity liberalisation have concluded that developments of a liberalised electricity market and cross border trade can be of benefit for the consumers and bring along a global environmental improvement. All these studies have assumed that a perfect competitive electricity market can be obtained. A number of imperfections, which inevitably will arise, have not been taken into account, - at least in the transition period. These imperfections can be technical, economic or tradition-bound, but may have political characteristics as well. The sixth paper in this thesis surveys those market imperfections which are most likely to appear. Market imperfections can, for example, have structural or political characteristics that imply non-optimal competitive behaviour, e.g., the means to achieve political goals may hinder the desirable effects of the liberalisation. This can, for example, come from the creation of suitable arrangements for survival and enlargement of

  2. Combinatorial Topic Models using Small-Variance Asymptotics

    OpenAIRE

    Jiang, Ke; Sra, Suvrit; Kulis, Brian

    2016-01-01

    Topic models have emerged as fundamental tools in unsupervised machine learning. Most modern topic modeling algorithms take a probabilistic view and derive inference algorithms based on Latent Dirichlet Allocation (LDA) or its variants. In contrast, we study topic modeling as a combinatorial optimization problem, and derive its objective function from LDA by passing to the small-variance limit. We minimize the derived objective by using ideas from combinatorial optimization, which results in ...

  3. Adolescent Scalp Psoriasis: Update on Topical Combination Therapy

    OpenAIRE

    Osier, Emily; Gomez, Barbara; Eichenfield, Lawrence F.

    2015-01-01

    Plaque psoriasis can begin early in life and negatively affect quality of life. Topical agents are generally recommended as first-line therapy for plaque psoriasis. The synergy of a vitamin D analog and a steroid in a topical fixed-combination formulation provides more favorable effectiveness and tolerability as compared with either agent alone. The safety and effectiveness of a once-daily calcipotriene/betamethasone dipropionate topical suspension have been established in children 12 to 17 y...

  4. Main technical topics in 1999

    International Nuclear Information System (INIS)

    This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

  5. topicmodels: An R Package for Fitting Topic Models

    Directory of Open Access Journals (Sweden)

    Bettina Grun

    2011-05-01

    Full Text Available Topic models allow the probabilistic modeling of term frequency occurrences in documents. The fitted model can be used to estimate the similarity between documents as well as between a set of specified keywords using an additional layer of latent variables which are referred to as topics. The R package topicmodels provides basic infrastructure for fitting topic models based on data structures from the text mining package tm. The package includes interfaces to two algorithms for fitting topic models: the variational expectation-maximization algorithm provided by David M. Blei and co-authors and an algorithm using Gibbs sampling by Xuan-Hieu Phan and co-authors.

  6. Topical agents in burn care

    Directory of Open Access Journals (Sweden)

    Momčilović Dragan

    2002-01-01

    Full Text Available Introduction Understanding of fluid shifts and recognition of the importance of early and appropriate fluid replacement therapy have significantly reduced mortality in the early post burn period. After the bum patient successfully passes the resuscitation period, the burn wound represents the greatest threat to survival. History Since the dawn of civilization, man has been trying to find an agent which would help burn wounds heal, and at the same time, not harm general condition of the injured. It was not until the XX century, after the discovery of antibiotics, when this condition was fulfilled. In 1968, combining silver and sulfadiazine, fox made silver-sulfadiazine, which is a 1% hydro-soluble cream and a superior agent in topical treatment of burns today. Current topical agents None of the topical antimicrobial agents available today, alone or combined, have the characteristics of ideal prophylactic agents, but they eliminate colonization of burn wound, and invasive infections are infrequent. With an excellent spectrum of activity, low toxicity, and ease of application with minimal pain, silver-sulfadiazine is still the most frequently used topical agent. Conclusion The incidence of invasive infections and overall mortality have been significantly reduced after introduction of topical burn wound antimicrobial agents into practice. In most burn patients the drug of choice for prophylaxis is silver sulfadiazine. Other agents may be useful in certain clinical situations.

  7. Selected topics of fluid mechanics

    Science.gov (United States)

    Kindsvater, Carl E.

    1958-01-01

    the Euler, Froude, Reynolds, Weber, and Cauchy numbers are defined as essential tools for interpreting and using experimental data. The derivations of the energy and momentum equations are treated in detail. One-dimensional equations for steady nonuniform flow are developed, and the restrictions applicable to the equations are emphasized. Conditions of uniform and gradually varied flow are discussed, and the origin of the Chezy equation is examined in relation to both the energy and the momentum equations. The inadequacy of all uniform-flow equations as a means of describing gradually varied flow is explained. Thus, one of the definitive problems of river hydraulics is analyzed in the light of present knowledge. This report is the outgrowth of a series of short schools conducted during the spring and summer of 1953 for engineers of the Surface Water Branch, Water Resources Division, U. S. Geological Survey. The topics considered are essentially the same as the topics selected for inclusion in the schools. However, in order that they might serve better as a guide and outline for informal study, the arrangement of the writer's original lecture notes has been considerably altered. The purpose of the report, like the purpose of the schools which inspired it, is to build a simple but strong framework of the fundamentals of fluid mechanics. It is believed that this framework is capable of supporting a detailed analysis of most of the practical problems met by the engineers of the Geological Survey. It is hoped that the least accomplishment of this work will be to inspire the reader with the confidence and desire to read more of the recent and current technical literature of modern fluid mechanics.

  8. Quantum mechanics II advanced topics

    CERN Document Server

    Rajasekar, S

    2015-01-01

    Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

  9. Tracking Multiple Topics for Finding Interesting Articles

    Energy Technology Data Exchange (ETDEWEB)

    Pon, R K; Cardenas, A F; Buttler, D J; Critchlow, T J

    2007-02-15

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. Also by relating a topic's interestingness to an article's interestingness, iScore is able to achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 9% to 14% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.

  10. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

  11. 301 research topics from Skinner's book verbal behavior

    OpenAIRE

    Sundberg, Mark L.

    1991-01-01

    Skinner's (1957) analysis of verbal behavior addresses some of the most important issues in human behavior. However, relatively few of the analyses presented by Skinner in Verbal Behavior have been subjected to an experimental analysis. The current list of topics was assembled in an effort to stimulate empirical research on verbal behavior. The list contains thirty research areas with ten topics suggested for each area. A final topic, education, is presented as a challenge to behavior analysts.

  12. Weakly-supervised joint sentiment-topic detection from text

    OpenAIRE

    Lin, Chenghua; He, Yulan; Everson, Richard; Rüger, Stefan

    2012-01-01

    Sentiment analysis or opinion mining aims to use automated tools to detect subjective information such as opinions, attitudes, and feelings expressed in text. This paper proposes a novel probabilistic modeling framework called joint sentiment-topic (JST) model based on latent Dirichlet allocation (LDA), which detects sentiment and topic simultaneously from text. A reparameterized version of the JST model called Reverse-JST, by reversing the sequence of sentiment and topic generation in the mo...

  13. The Impact of Topic Congruence on Second Language Reading Comprehension

    OpenAIRE

    Marzieh Sadeghpour; Sayyed Mohammad Alavi

    2013-01-01

    The present study scrutinized the impact of congruent topics on the quality of L2 reading comprehension. 56 Iranian advanced-level students read 2 texts on a controversial topic, one on the advantages of child gender selection, and the other on disadvantages. Quality analysis of immediate and delayed recall tasks, defined as the amount of high and low-level information recalled correctly, was performed by analysis of variance. Results revealed that topic congruence affected immediate recall o...

  14. Heide von Felden: Bildung und Geschlecht zwischen Moderne und Postmoderne. Zur Verknüpfung von Bildungs-, Biographie- und Genderforschung. Opladen: Leske + Budrich 2003 (Band 21 der Reihe: Studien zu Erziehungswissenschaft und Bildungsforschung) [Rezension

    OpenAIRE

    Bönold, Fritjof

    2005-01-01

    Rezension zu: Heide von Felden: Bildung und Geschlecht zwischen Moderne und Postmoderne. Zur Verknüpfung von Bildungs-, Biographie- und Genderforschung. Opladen: Leske + Budrich 2003 (Band 21 der Reihe: Studien zu Erziehungswissenschaft und Bildungsforschung)

  15. Topics in topological band systems

    Science.gov (United States)

    Huang, Zhoushen

    The discovery of integer quantum Hall effect and its subsequent theoretical formulation heralded a new paradigm of thinking in condensed matter physics, which has by now blossomed into the rapidly growing field of topological phases. In this work we investigate several mutually related topics in the framework of topological band theory. In Chapter 2, we study solutions to boundary states on a lattice and see how they are related to the bulk topology. To elicit a real space manifestation of the non-trivial topology, the presence of a physical edge is not strictly necessary. We study two other possibilities, namely the entanglement spectrum associated with an imaginary spatial boundary, and the localization centers of Wannier functions, in Chapters 3,4, and 5. Topological classification through discrete indices is so far possible only for systems described by pure quantum states---in the existing scheme, quantization is lost for systems in mixed states. In Chapter 6, we present a program through which discrete topological indices can be defined for topological band systems at finite temperature, based on Uhlmann's parallel transport of density matrices. The potential of topologocal insulators in realistic applications lies in the existence of Dirac nodes on its surface spectrum. Dirac physics, however, is not exclusive to TI surfaces. In a recently discovered class of materials known as Weyl semimetals, energy nodes which emit linear dispersions also occur in the bulk material. In Chapter 7, we study the possibility of resonance states induced by localized impurities near the nodal energy in Weyl semimetals, which will help us in understanding the stability of density-of-state suppression at the energy nodes. Finally, in Chapter 8, we apply the topological characterization developed for noninteracting particles to a class of interacting spin models in 3D, which are generalizations of Kitaev's honeycomb model, and identify several exotic quantum phases such as spin

  16. Approach to extracting hot topics based on network traffic content

    Institute of Scientific and Technical Information of China (English)

    Yadong ZHOU; Xiaohong GUAN; Qindong SUN; Wei LI; Jing TAO

    2009-01-01

    This article presents the formal definition and description of popular topics on the Internet,analyzes the relationship between popular words and topics,and finally introduces a method that uses statistics and correlation of the popular words in traffic content and network flow characteristics as input for extracting popular topics on the Internet.Based on this,this article adapts a clustering algorithm to extract popular topics and gives formalized results.The test results show that this method has an accuracy of 16.7% in extracting popular topics on the Internet.Compared with web mining and topic detection and tracking (TDT),it can provide a more suitable data source for effective recovery of Internet public opinions.

  17. Rosacea-like eruption due to topical pimecrolimus.

    Science.gov (United States)

    El-Heis, S; Buckley, D A

    2015-05-01

    Topical calcineurin inhibitors have been used outside their approved indications for a number of conditions, including topical steroid-induced rosacea. However, tacrolimus ointment itself has been reported to trigger rosacea in a small number of cases. We report a case of a rosacea-like eruption in a 39-year-old woman occurring after the use of pimecrolimus cream for 12 months for atopic dermatitis. Withdrawal of pimecrolimus combined with treatment with oral lymecycline, topical metronidazole, and an emollient resulted in resolution of the eruption. There have been 5 previously reported cases of a topical pimecrolimus-induced rosacea-like eruption suggesting that this rare side-effect may be a class effect of all topical calcineurin inhibitors. Dermatologists prescribing these drugs should be aware of this uncommon complication and may wish to warn patients of its occurrence as a potential side-effect when using topical calcineurin inhibitors in facial skin in adults. PMID:26295863

  18. Two topics in quantum chromodynamics

    International Nuclear Information System (INIS)

    The two topics are (1) estimates of perturbation theory coefficients for R(e+e- → hadrons), and (2) the virtual-photon structure function, with emphasis on the analytic behavior in its squared mass. 20 refs., 4 figs., 2 tabs

  19. Topics in combinatorial pattern matching

    DEFF Research Database (Denmark)

    Vildhøj, Hjalte Wedel

    This dissertation studies problems in the general theme of combinatorial pattern matching. More specifically, we study the following topics: Longest Common Extensions. We revisit the longest common extension (LCE) problem, that is, preprocess a string T into a compact data structure that supports...

  20. Sick sinus syndrome associated with topical timolol maleate instillation

    Directory of Open Access Journals (Sweden)

    Harpreet S Walia

    2011-01-01

    Full Text Available A 70-year-old black woman presented with intermittent palpitations and dyspnea was found to be bradycardic with a normal sinus rhythm. She had instilled her topical timolol maleate approximately 30 minutes prior to each of these episodes. Topical timolol was discontinued and the conduction abnormality resolved. She was diagnosed as having intermittent sinus bradycardia with intermittent atrioventricular block, likely induced by topical beta-blocker therapy. Topical timolol maleate is an effective treatment for ocular hypertension, acting by reducing aqueous fluid production. However, it can induce systemic side effects and should be used with caution in patients with, or predisposed to, cardiac or respiratory depression.

  1. Topics on cryogenic design of superconducting magnet for fusion reactor

    International Nuclear Information System (INIS)

    The design concepts and the research topics on cryogenic stability, quench and refrigeration of superconducting magnets for fusion experimental reactor are reviewed. Emphasis is given to introduce their fundamental ideas as well as the results obtained by various experiments at National Institute for Fusion Science, however, some of the other recent topics are also included. (author)

  2. Investigation of some topical formulations containing dexpanthenol.

    Science.gov (United States)

    Stozkowska, Wiesława; Piekoś, Ryszard

    2004-01-01

    Owing to its ability to regenerate epidermal cells Dexpanthenol (D-panthenol; chemically known as (+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide) has found use for the treatment of patholytic ileus and postoperative distention. The purpose of research was to develop a gel containing dexpanthenol by monitoring the effect of various concentrations of a gelating agent on the activity of the ciliary apparatus. A system containing 2.5% of hydroxyethylcellulose was optimal for the preparation of the gel. Together with a formulation containing 5% of dexpanthenol, drops with equal concentration of the active compound were tested for comparison. Physical characteristics, such as osmotic pressure, acidity, density and viscosity of the preparation were determined as well as its microbiological sterility. The anti-inflammatory activity of the gel was determined following its topical application. Epidermal tests showed its good tolerance after topical application to the shaved skin of guinea pigs. PMID:15794335

  3. Topical and transdermal delivery of caffeine.

    OpenAIRE

    Luo, L.; Lane, M. E.

    2015-01-01

    Caffeine is administered topically and transdermally for a variety of pharmaceutical and cosmetic applications and it is also used as a model hydrophilic compound in dermal risk assessment studies. This review considers the physicochemical and permeation properties of caffeine with reference to its delivery to and through the skin. Since it has been used as a model compound the findings have implications for the delivery of many hydrophilic compounds having similar properties. Various passive...

  4. Supporting information visualization through topic maps

    OpenAIRE

    Marcos, Adérito; Oliveira, Alexandre Rocha; Malgueiro, Octávio; Grave, Luís

    2002-01-01

    We are living a phenomenon of accelerated information production with different accessing sources. Hence users are faced with a growing problem: accessing (navigation) and filtering specific information contained in large datasets, which are increasing in size. Procedures such as data filtering and gathering are now simplified through a new concept known as Topic Maps. The application of Virtual Reality technologies enables to present and interact with multidimensional information...

  5. Efficacy of topical calcineurin inhibitors in vitiligo.

    Science.gov (United States)

    Wong, Russell; Lin, Andrew N

    2013-04-01

    Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is superior to placebo, especially for UV resistant areas, such as bony prominences of the extremities. When used alone, tacrolimus 0.1% ointment is almost as effective as clobetasol propionate 0.05% ointment. Other studies suggest it can also be effective for facial lesions. Double blind studies show that pimecrolimus 1% cream combined with narrow band UVB is superior to placebo, especially for facial lesions. Additional studies would further clarify the role of topical calcineurin inhibitors in vitiligo. PMID:23331250

  6. Faulkner: A Biography. By Joseph Blotner. New York: Random House, 1974. Faulkner: A Biography. By Joseph Blotner. New York: Random House, 1974.

    Directory of Open Access Journals (Sweden)

    Eileen Klink

    2008-04-01

    Full Text Available Until the publication of The Sound and the Fury, October 7, 1929, William Faulkner knew more rejection than acceptance. Sartoris, published early the same year, had received mixed reviews, and Faulkner was "disappointed and discouraged by its reception" (Blotner: 236. However, The Sound and the Fury granted him his first taste of critical acclaim and international fame; he was heralded as a new Euripides, and his book was compared with Greek tragedy. Until the publication of The Sound and the Fury, October 7, 1929, William Faulkner knew more rejection than acceptance. Sartoris, published early the same year, had received mixed reviews, and Faulkner was "disappointed and discouraged by its reception" (Blotner: 236. However, The Sound and the Fury granted him his first taste of critical acclaim and international fame; he was heralded as a new Euripides, and his book was compared with Greek tragedy.

  7. Handeln von Ärztinnen und Ärzten im biographischen Kontext : zur Verknüpfung von Biographie- und Interaktionsanalyse

    OpenAIRE

    Witte, Nicole

    2006-01-01

    "Die zentrale Fragestellung des Vortrages ist die nach der biographischen Entwicklung gegenwärtigen Interaktionen der MedizinerInnen mit ihren PatientInnen. Hierbei muss betont werden, dass es nicht darum geht, lineare Kausalzusammenhänge anzunehmen, sprich von Ursache- und Wirkungsbeziehungen auszugehen, sondern darum, die wechselseitige Wirkungsbeziehung der beiden Ebenen zu rekonstruieren. Ziel ist es also, die Entwicklungsebenen Biographie und Ablauf einer einzelnen Begegnung in ihrer Int...

  8. On Ouyang Xiu's biography literature theory%论欧阳修的传记文学理论

    Institute of Scientific and Technical Information of China (English)

    徐裕敏

    2012-01-01

    欧阳修是宋代杰出的传记文学作家,他的传记文学理论在坚持史学原则的基础上,从文学的角度探讨了传记的写作,包含了传记写作的态度、目的、方法、语言等问题,使传记文学理论的研究在史学和文学的两极中得到平衡,为后代传记文学理论的发展开启了新方向。%Ouyang Xiu was an outstanding literary biographer in the Song Dynasty. His biography literature theory explored the biography writing from the angle of literature on his historical principles. His theory contained biographical writing attitude, aim, method, language problems and sought the balance between history and literature, offering the new direction for the biography literature theory development.

  9. Topics from the theory of numbers

    CERN Document Server

    Grosswald, Emil

    1984-01-01

    Many of the important and creative developments in modern mathematics resulted from attempts to solve questions that originate in number theory. The publication of Emil Grosswald’s classic text presents an illuminating introduction to number theory. Combining the historical developments with the analytical approach, Topics from the Theory of Numbers offers the reader a diverse range of subjects to investigate, including: * divisibility * congruences * the Riemann zeta function * Diophantine equations and Fermat’s conjecture * the theory of partitions Comprehensive in nature, Topics from the Theory of Numbers is an ideal text for advanced undergraduates and graduate students alike. "In my opinion it is excellent. It is carefully written and represents clearly a work of a scholar who loves and understands his subject. One can only wish more authors would take such pains and would be as good and honest expositors as Grosswald." — Marc Kac "This book is designed for use in a first course in number theory at...

  10. Ethical use of topical corticosteroids

    Directory of Open Access Journals (Sweden)

    Abir Saraswat

    2014-01-01

    Full Text Available Dermatologists rely very heavily on corticosteroids for treating many common dermatoses. Concerns about their incorrect use are widely expressed both in lay public and specialist discourse. From the point of view of medical ethics, issues of autonomy, beneficence and non-maleficence are all raised frequently when we prescribe topical corticosteroids to our patients. We need to be aware of situations when conflicts between these issues arise and have a clear thought process about resolving them. This can only be achieved if we have a thorough understanding of the skin disease being treated coupled with expertise in the use of the varied potencies and available dosage forms of topical corticosteroids. A good understanding of human psychology and effective communication is also needed to use these agents optimally.

  11. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis.

    Science.gov (United States)

    Del Rosso, James Q; Kircik, Leon H

    2013-11-01

    Superficial cutaneous fungal infections (SCFIs) are commonly encountered in clinical practice in the United States, and comprise infections of the skin by dermatophytes and yeasts. The most common organisms causing SCFI are dermatophytes, especially Trichophyton spp. With the exception of onchomycosis and tinea capitis, most cases of SCFIs are amenable to properly selected topical antifungal therapy used over an adequate period of time. A variety of topical antifungal agents are available for the treatment of SCFIs, and they encompass a few major chemical classes: the polyenes (ie, nystatin), imidazoles (ie, ketoconazole, econazole, oxiconazole, etc), allylamines (ie, naftifine, terbinafine), benzylamines (ie, butenafine), and hydroxypyridones (ie, ciclopirox). The 2 major classes that represent the majority of available topical antifungal agents are the azoles and the allylamines. Overall, the allylamines are superior to the azoles in activity against dermatophytes, although both are clinically effective. The reverse is true against yeasts such as Candida spp and Malassezia spp, although topical allylamines have proven to be efficacious in some cases of tinea versicolor and cutaneous candidiasis. Naftifine, a topical allylamine, is fungicidal in vitro against a wide spectrum of dermatophyte fungi and has been shown to be highly effective against a variety of cutaneous dermatophyte infections. Rapid onset of clinical activity and favorable data on sustained clearance of infection have been documented with naftifine. The more recent addition of naftifine 2% cream has expanded the armamentarium, with data supporting a clinically relevant therapeutic reservoir effect after completion of therapy. PMID:24196340

  12. LEPA’S: TOPICAL APPLICATION OF AYURVEDA

    Directory of Open Access Journals (Sweden)

    Bali Yogitha

    2012-07-01

    Full Text Available The goal of medicine is to prevent the disease, restore health and suffering. Understanding and appropriately treating pain is an important component of this goal. Pain is universally recognized as a signal of disease or injury and is a common reason for patients to seek the medical care. Analgesics given in the form of topical application is said to provide the therapeutic benefits by reaching the local tissue and with minimal side effects like irritation of the skin etc. Apart form relieving the pain, topical application is also useful in treating various skin lesions, ulcers. Ayurveda, a science of life and traditional system of medicine native to India is also a form of Alternative medicine. Ayurveda also called as Astanga Ayurveda contains eight branches such as kayachikitsa(internal medicine, shalya tantra (surgery, shalakya tantra (ENT, agada tantra (toxicology and forensic medicine, bhutavidya (treatment of psychic diseases, kaumarabhrutya(paediatrics, rasayana tantra (rejuvenation treatment and vajikarana (aphrodiasics. Ayurveda, an ancient science has vast description of these topical applications in the name of lepa described both as the chikitsa of various disease conditions and for beauty.

  13. Comparison of topical tretinoin and betamethasone in oral lichen planus

    Directory of Open Access Journals (Sweden)

    Kar H

    1996-01-01

    Full Text Available Thirty-one patients of oral lichen planus were enrolled in this study and two groups were made. Group 1 consisting of 16 patients who applied topical tretinoin 0.05% and Group 2 comprising of 15 patients who were given topical betamethasone dipropionate 0.05%. The patients applying tretinoin showed statistically significant improvement as compared to patients applying betamethasone.

  14. Topics in Finance Part VI--Capital Budgeting

    Science.gov (United States)

    Laux, Judy

    2011-01-01

    This series on the theory of financial management offers insight into the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts as they apply to major topics in finance. The current article investigates capital budgeting. Much literature addresses this topic, with a number of articles challenging mainstream…

  15. Immigration, Cultural-Linguistic Diversity, and Topics in Language Disorders

    Science.gov (United States)

    Cheng, Li-Rong Lilly

    2010-01-01

    This article summarizes 4 topics contributed by the author over the last 30 years of "Topics in Language Disorders" that address the issues of immigration, migration, and refugees. The focus is on the historical perspectives on evolution of terminologies from limited English proficient to English language learner and English as a new language.…

  16. Topics in Finance Part VII--Dividend Policy

    Science.gov (United States)

    Laux, Judy

    2011-01-01

    This series inspects the major topics in finance, reviewing the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts. The current article, devoted to dividend policy, also reviews the topic as presented in textbooks and the literature.

  17. Topical macrolide immunomodulators: a role in the treatment of vitiligo?

    NARCIS (Netherlands)

    Tjioe, M.; Vissers, W.H.P.M.; Gerritsen, M.J.P.

    2006-01-01

    Recently, topical macrolide immunomodulators have been successfully introduced in the treatment of atopic dermatitis. With the growing interest in this new line of topical immunosuppressants, research into the efficacy of these medicines in other T-cell-mediated skin diseases, such as psoriasis, lic

  18. Preface to Special Topic: Optofluidics

    OpenAIRE

    Liu, Ai-qun

    2010-01-01

    This Special Topic section of Biomicrofluidics is on optofluidics or micro-optofluidic systems (MOFS), a burgeoning technology that aims to manipulate light and fluid at microscale and exploits their interaction to create highly versatile devices and integrated systems. This special issue puts together various contributed articles focusing on optofluidics or MOFS, which help inspire new research ideas and innovation in the microfluidics and nanofluidics community.

  19. Stochastic Analysis and Related Topics

    CERN Document Server

    Ustunel, Ali

    1988-01-01

    The Silvri Workshop was divided into a short summer school and a working conference, producing lectures and research papers on recent developments in stochastic analysis on Wiener space. The topics treated in the lectures relate to the Malliavin calculus, the Skorohod integral and nonlinear functionals of white noise. Most of the research papers are applications of these subjects. This volume addresses researchers and graduate students in stochastic processes and theoretical physics.

  20. Topics in clinical oncology. 15

    International Nuclear Information System (INIS)

    The monograph comprising primarily papers on topical subjects of oncology and cancer research, contains also a selection of papers presented at the 2. Congress of the Czechoslovak Society of Nuclear Medicine and Radiation Hygiene. Seven papers were selected on behalf of their subject related to clinical oncology. All of them were iputted in INIS; five of them deal with the scintiscanning of the skeleton of cancer patients, one with radioimmunodetection of tumors, and one with radionuclide lymphography. (A.K.)

  1. Hot topics from the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Glenzinski, D.; /Fermilab

    2008-01-01

    The Tevatron Run-II began in March 2001. To date, both the CDF and D0 experiments have collected 1 fb{sup -1} of data each. The results obtained from this data set were summarized at this conference in 39 parallel session presentations covering a wide range of topics. The author summarizes the most important of those results here and comments on some of the prospects for the future.

  2. 76 FR 81806 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

    Science.gov (United States)

    2011-12-29

    ... exclusivity (69 FR 501, January 6, 2004). The supplemental ANADA is approved as of September 21, 2011, and 21... HUMAN SERVICES Food and Drug Administration 21 CFR Part 524 Ophthalmic and Topical Dosage Form New... for Veterinary Medicine, 21 CFR part 524 is amended as follows: PART 524--OPHTHALMIC AND...

  3. Modern topics in theoretical nuclear physics

    OpenAIRE

    Jennings, B. K.; Schwenk, A

    2005-01-01

    Over the past five years there have been profound advances in nuclear physics based on effective field theory and the renormalization group. In this brief, we summarize these advances and discuss how they impact our understanding of nuclear systems and experiments that seek to unravel their unknowns. We discuss future opportunities and focus on modern topics in low-energy nuclear physics, with special attention to the strong connections to many-body atomic and condensed matter physics, as wel...

  4. Efficient Learning for Undirected Topic Models

    OpenAIRE

    Gu, Jiatao; Li, Victor O. K.

    2015-01-01

    Replicated Softmax model, a well-known undirected topic model, is powerful in extracting semantic representations of documents. Traditional learning strategies such as Contrastive Divergence are very inefficient. This paper provides a novel estimator to speed up the learning based on Noise Contrastive Estimate, extended for documents of variant lengths and weighted inputs. Experiments on two benchmarks show that the new estimator achieves great learning efficiency and high accuracy on documen...

  5. Antiophidian sera sterility control: topics in perspective

    OpenAIRE

    Paula Gomes Santos; Dilvani Oliveira Santos; Lilia Ribeiro Seródio; Rachel de Souza Marinho; Carlos Rangel Rodrigues; Lucio Mendes Cabral; Marcelo de Pádula; Valéria Pereira de Sousa; Helena Carla Castro

    2009-01-01

    The aim of this work is to review the most important topics about the antiophidic sera sterility, including obtaining methods, sterilization procedures and clean room control using Vital Brazil Institute (VBI) as an example. Bibliographical research was performed through Medline, Lilacs, PubMed, ISI and the Fundação Oswaldo Cruz - RJ and VBI Libraries, from 1960 to 2009. The antiophidic sera for human use are immunobiologic products produced in Brazil by three national laboratories, including...

  6. LEPA’S: TOPICAL APPLICATION OF AYURVEDA

    OpenAIRE

    Bali Yogitha

    2012-01-01

    The goal of medicine is to prevent the disease, restore health and suffering. Understanding and appropriately treating pain is an important component of this goal. Pain is universally recognized as a signal of disease or injury and is a common reason for patients to seek the medical care. Analgesics given in the form of topical application is said to provide the therapeutic benefits by reaching the local tissue and with minimal side effects like irritation of the skin etc. Apart form relievin...

  7. Topics in Cement and Concrete Research

    OpenAIRE

    Brouwers, H. J. H.

    2006-01-01

    The present paper addresses several topics in regard to the sustainable design and use of concrete. First, major features concerning the sustainable aspects of the material concrete are summarised. Then the major constituent, from an environmental point of view, cement is discussed in detail, particularly the hydration and application of slag cement. The intelligent combining of mineral oxides, which are found in clinker, slag, fly ashes etc., is designated as mineral oxide engineering. It re...

  8. LECITHINISED MICROEMULSIONS FOR TOPICAL DELIVERY OF TRETINOIN

    OpenAIRE

    Khanna Surabhi; Katare O P; Drabu Sushma

    2010-01-01

    Tretinoin is indicated for the management of acne, photoaged skin, psoriasis and other skin disorders and also for severe conditions like acute promyelocytic anaemia and squamous cell carcinoma of the skin. The potential of tretinoin in these conditions is limited due to want of a proper delivery vehicle. In order to develop alternate formulations for the topical administration of tretinoin, lecithinsed microemulsions were prepared and evaluated as delivery vehicles. These systems were prepar...

  9. L’Empire ottoman à travers la biographie picaresque d’Eliya Karmona Ottoman empire through picaresque biography of Eliya Karmona

    Directory of Open Access Journals (Sweden)

    Marie-Christine Varol

    2012-05-01

    picaresque novel which conforms to the law of the genre, but which has common features with other aspects of genres cultivated by Spanish Jews: accounts of travel, exemplary narratives, the treatise on the ways and customs, the fictionalized remembrances, the proverbs. Very Ottoman elements are also found there, like the private diary recounting minor deeds expenditure and receipts, which have shown concerned an Ottoman practice very useful as a source of historical information. The author has a sharp and comical critical view of gravity of the Ottoman system which obstructs every initiative, but he also criticizes the communal inflexibility which heavily constrains personal initiative, the inadaptability of the structures and consequently the ineffectiveness of the strategies put in place by individuals to survive. Nevertheless his work indirectly reveals a certain nostalgia for the vanished world. One perceives the hero’s admiration and his attachment to certain old world values, and one cannot refrain from admitting that he is correct when one measures what the Jewish communities have lost with the disappearance of the Ottoman empire.

  10. Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy

    Directory of Open Access Journals (Sweden)

    Alexander L. Pan

    2012-01-01

    Full Text Available Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.

  11. Topic prominence in Chinese EFL learners’ interlanguage

    OpenAIRE

    Li, Shaopeng; Yang, Lianrui

    2014-01-01

    The present study aims to investigate the general characteristics of topic-prominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspec- tive. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004). The research target are the topic chain, which is the main topic-prominent structure in Chinese discourse, and zero anaphora, which is the most common t...

  12. Sampled Weighted Min-Hashing for Large-Scale Topic Mining

    OpenAIRE

    Fuentes-Pineda, Gibran; Meza-Ruiz, Ivan Vladimir

    2015-01-01

    We present Sampled Weighted Min-Hashing (SWMH), a randomized approach to automatically mine topics from large-scale corpora. SWMH generates multiple random partitions of the corpus vocabulary based on term co-occurrence and agglomerates highly overlapping inter-partition cells to produce the mined topics. While other approaches define a topic as a probabilistic distribution over a vocabulary, SWMH topics are ordered subsets of such vocabulary. Interestingly, the topics mined by SWMH underlie ...

  13. Nanociência e nanotecnologia como temáticas para discussão de ciência, tecnologia, sociedade e ambiente Nanoscience and Nanotechnology as topical themes for a discussion on science, technology, society and environment

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2010-01-01

    Full Text Available A educação científica e tecnológica tem sido intensamente discutida hodiernamente, tendo em vista o compromisso último das diferentes instituições de ensino: formar cidadãos capazes de entender o mundo no qual estão inseridos. Com efeito, a apreciação de temas da atualidade se constitui em abordagem bastante salutar para motivar as discussões sobre tais temáticas em sala de aula. Neste domínio se inserem a nanociência e a nanotecnologia, saberes que podem ser abordados de forma interdisciplinar, envolvendo as ciências exatas e da natureza de forma articulada às ciências humanas e sociais. A proposição de eixos temáticos para o emprego da nanociência e da nanotecnologia como mote para o ensino de ciências, construídos a partir da revisão da literatura sob um enfoque ciência-tecnologia-sociedade-ambiente (CTSA é o escopo do presente artigo.Scientific and technological education has been, in present times, fairly-well discussed, with focus on the ultimate commitment of the various teaching institutions: to promote the formation of citizens who are able to understand the world where they live in. Actually, the choice of contemporary topics is by itself a very strategic approach to motivate discussions on such matters in the classroom. Nanoscience and nanotechnology come up very properly in such a domain, which can be treated in an interdisciplinary way, by joining exact and natural sciences on the one hand, and human and social sciences on the other hand. The proposal of thematic directions to approach nanoscience and nanotechnology as a motto for science teaching, set up from reviewing the literature under the optics of Science-Technology-Society-Environment (STSE, is the main goal of the present paper.

  14. Application of Topic Map on Knowledge Organization

    Directory of Open Access Journals (Sweden)

    Sou-shan Wu

    2003-06-01

    Full Text Available Knowledge management (KM has received much attention from both academics and practitioners in the past few years. Following the KM trend, many organizations have built their own knowledge repositories or data warehouses. However, information or knowledge is still scattered everywhere without being properly managed. The rapid growth of the Internet accelerates the creation of unstructured and unclassified information and causes the explosion of information overload. The effort of browsing information through general-purpose search engines turns out to be tedious and painstaking. Hence, an effective technology to solve this information retrieval problem is much needed. The purpose of this research is to explore the application of text mining technique in organizing knowledge stored in unstructured natural language text documents. Major components of text mining techniques required for topic map in particular will be presented in detail.Two sets of unstructured documents are utilized to demonstrate the usage of SOM for topic categorization. The first set of documents is a collection of speeches given by Y.C. Wang, Chairman of the Taiwan Plastics Group, and the other is the collection of all laws and regulations related to securities and future markets in Taiwan. We also try to apply text mining to these two sets of documents to generate their respective topic maps, thus revealing the differences between organizing explicit and tacit knowledge as well as the difficulties associated with tacit knowledge.[Article content in Chinese

  15. Tracking Multiple Topics for Finding Interesting Articles

    Energy Technology Data Exchange (ETDEWEB)

    Pon, R K; Cardenas, A F; Buttler, D J; Critchlow, T J

    2008-01-03

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. iScore is able to achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 25% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.

  16. Topics on Electricity Transmission Pricing

    International Nuclear Information System (INIS)

    -subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. To start with, chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently coordinate the allocation of transmission

  17. Topical protection of human esophageal mucosal integrity.

    Science.gov (United States)

    Woodland, P; Batista-Lima, F; Lee, C; Preston, S L; Dettmar, P; Sifrim, D

    2015-06-15

    Patients with nonerosive reflux disease exhibit impaired esophageal mucosal integrity, which may underlie enhanced reflux perception. In vitro topical application of an alginate solution can protect mucosal biopsies against acid-induced changes in transepithelial electrical resistance (TER). We aimed to confirm this finding in a second model using 3D cell cultures and to assess prolonged protection in a biopsy model. We assessed the protective effect of a topically applied alginate solution 1 h after application. 3D cell cultures were grown by using an air-liquid interface and were studied in Ussing chambers. The apical surface was "protected" with 200 μl of either alginate or viscous control or was unprotected. The tissue was exposed to pH 3 + bile acid solution for 30 min and TER change was calculated. Distal esophageal mucosal biopsies were taken from 12 patients and studied in Ussing chambers. The biopsies were coated with either alginate or viscous control solution. The biopsies were then bathed in pH 7.4 solution for 1 h. The luminal chamber solution was replaced with pH 2 solution for 30 min. Percentage changes in TER were recorded. In five biopsies fluorescein-labeled alginate solution was used to allow immunohistological localization of the alginate after 1 h. In the cell culture model, alginate solution protected tissue against acid-induced change in TER. In biopsies, 60 min after protection with alginate solution, the acidic exposure caused a -8.3 ± 2.2% change in TER compared with -25.1 ± 4.5% change after protection with the viscous control (P < 0.05). Labeled alginate could be seen coating the luminal surface in all cases. In vitro, alginate solutions can adhere to the esophageal mucosa for up to 1 h and exert a topical protectant effect. Durable topical protectants can be further explored as first-line/add-on therapies for gastroesophageal reflux disease. PMID:25907692

  18. The Impact of Topic Congruence on Second Language Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Marzieh Sadeghpour

    2013-09-01

    Full Text Available The present study scrutinized the impact of congruent topics on the quality of L2 reading comprehension. 56 Iranian advanced-level students read 2 texts on a controversial topic, one on the advantages of child gender selection, and the other on disadvantages. Quality analysis of immediate and delayed recall tasks, defined as the amount of high and low-level information recalled correctly, was performed by analysis of variance. Results revealed that topic congruence affected immediate recall of both high and low-level information, and also delayed recall of low-level information. Findings showed that the effect of congruent topics on reading recall was detrimental; participants recalled less information from the passage with congruent topic than a passage with incongruent topic. Outcomes of the study suggest that controversial topics should be selected more cautiously, because they may not truly reflect L2 readers’ reading comprehension.Keywords: congruent topic, L2 reading, readers’ attitude, immediate recall, delayed recall

  19. Topics in black hole evaporation

    International Nuclear Information System (INIS)

    Two major aspects of particle creation by gravitational fields of black holes are studied: the neutrino emission from rotating black holes; and interactions between scalar particles emitted by a black hole. Neutrino emission is investigated under three topics: The asymmetry of the angular dependence of neutrino emission from rotating black holes; the production of a local matter excess by rotating black holes in a baryon symmetric universe; and cosmological magnetic field generation by neutrinos from evaporating black holes. Finally the author studies the effects of interactions on the black hole evaporation process

  20. Topical Anesthetic Abuse Keratopathy and its Clinical Progression

    Directory of Open Access Journals (Sweden)

    Volkan Dayanır

    2013-08-01

    Full Text Available To report a case series with topical anesthetic abuse and to define the clinical progression of the disease. Six eyes of three topical anesthetic abuser patients with various corneal abnormalities are reviewed. Signs of the disease are presented in order to document the natural progression of the disease. A report was filed to the General Directorate of Pharmaceuticals and Pharmacy, Ministry of Health, Ankara, Turkey describing the outcome of uncontrolled use of topical anesthetic. Topical anesthetic abuse can result in serious corneal complications such as corneal epithelium defect, ring keratitis, stromal infiltrate, hypopyon, superficial and deep corneal vascularization, corneal lysis, and at last spontaneous perforation. The General Directorate of Pharmaceuticals and Pharmacy issued that topical anesthetics can only be prescribed by an ophthalmologist up to four boxes a month, the prescription must be kept for one, year and criminal action will be taken against pharmacies disregarding these provisions. (Turk J Ophthalmol 2013; 43: 289-93

  1. Improving Text Categorization By Using A Topic Model

    Directory of Open Access Journals (Sweden)

    Wongkot Sriurai

    2011-12-01

    Full Text Available Most text categorization algorithms represent a document collection as a Bag of Words (BOW.The BOWrepresentation is unable to recognize synonyms from a given term set and unable to recognize semanticrelationships between terms. In this paper, we apply the topic-model approach to cluster the words into aset of topics. Words assigned into the same topic are semantically related. Our main goal is to comparebetween the feature processing techniques of BOW and the topic model. We also apply and comparebetween two feature selection techniques: Information Gain (IG and Chi Squared (CHI. Three textcategorization algorithms: Naïve Bayes (NB, Support Vector Machines (SVM and Decision tree, areused for evaluation. The experimental results showed that the topic-model approach for representing thedocuments yielded the best performance based on F1 measure equal to 79% under the SVM algorithmwith the IG feature selection technique.

  2. On-line Hot Topic Recommendation Using Tolerance Rough Set Based Topic Clustering

    Directory of Open Access Journals (Sweden)

    Yonghui Wu

    2010-04-01

    Full Text Available In this paper we present our research of online hot topic detection and label extraction method for our hot topic recommendation system. Using a new topical feature selection method, the feature space is compressed suitable for an online system. The tolerance rough set model is used to enriching the small set of topical feature words to a topical approximation space. According to the distance defined on the topical approximation space, the web pages are clustered into groups which will be merged with document overlap. The topic labels are extracted based on the approximation topical space enriched with the useful but high frequency topical words dropped by the clustering process. The experiments show that our method could generate more information abundant classes and more topical class labels, alleviate the topical drift caused by the non-topical and noise words.

  3. Web mining for topics defined by complex and precise predicates

    Science.gov (United States)

    Lee, Ching-Cheng; Sampathkumar, Sushma

    2004-04-01

    The enormous growth of the World Wide Web has made it important to perform resource discovery efficiently for any given topic. Several new techniques have been proposed in the recent years for this kind of topic specific web-mining, and among them a key new technique called focused crawling which is able to crawl topic-specific portions of the web without having to explore all pages. Most existing research on focused crawling considers a simple topic definition that typically consists of one or more keywords connected by an OR operator. However this kind of simple topic definition may result in too many irrelevant pages in which the same keyword appears in a wrong context. In this research we explore new strategies for crawling topic specific portions of the web using complex and precise predicates. A complex predicate will allow the user to precisely specify a topic using Boolean operators such as "AND", "OR" and "NOT". Our work will concentrate on defining a format to specify this kind of a complex topic definition and secondly on devising a crawl strategy to crawl the topic specific portions of the web defined by the complex predicate, efficiently and with minimal overhead. Our new crawl strategy will improve the performance of topic-specific web crawling by reducing the number of irrelevant pages crawled. In order to demonstrate the effectiveness of the above approach, we have built a complete focused crawler called "Eureka" with complex predicate support, and a search engine that indexes and supports end-user searches on the crawled pages.

  4. On-line Hot Topic Recommendation Using Tolerance Rough Set Based Topic Clustering

    OpenAIRE

    Yonghui Wu; Yuxin Ding; Xiaolong Wang; Jun Xu

    2010-01-01

    In this paper we present our research of online hot topic detection and label extraction method for our hot topic recommendation system. Using a new topical feature selection method, the feature space is compressed suitable for an online system. The tolerance rough set model is used to enriching the small set of topical feature words to a topical approximation space. According to the distance defined on the topical approximation space, the web pages are clustered into groups which will be mer...

  5. [Topical administration of cyclosporin in psoriasis vulgaris].

    Science.gov (United States)

    Bunse, T; Schulze, H J; Mahrle, G

    1990-06-01

    Two groups of patients with chronic plaque psoriasis were topically treated either with 10% cyclosporin in a jelly base or with 5% cyclosporin in an ointment base under occlusion. We found that cyclosporin penetrates into the lower epidermis and the dermis, when it is applied under occlusion. Obviously, the target cells are neutrophil granulocytes, since they decrease in number under cyclosporin, whereas the other inflammatory cells as well as the epidermal proliferation remain unchanged. In contrast to systemic application of cyclosporin, we did not observe any clinical differences between plaques treated with cyclosporin and those treated with placebo. PMID:2202163

  6. Selected topics in heavy flavour physics

    International Nuclear Information System (INIS)

    We review the status of flavour physics in spring 2014. The numerous accurate new measurements of flavour experiments have enabled us to test our theoretical understanding of flavour processes with an unprecedented precision. At first sight the dominant amount of measurements seems to be standard model like. Having a closer look one finds, however, that in most of the observables there is still some considerable space for new effects. In addition many discrepancies are still not yet settled. For further investigations and definite conclusions an improvement of the theoretical precision as well as the experimental one is mandatory. Communicated by Professor Alan Martin (topical review)

  7. Topics in radiation dosimetry radiation dosimetry

    CERN Document Server

    1972-01-01

    Radiation Dosimetry, Supplement 1: Topics in Radiation Dosimetry covers instruments and techniques in dealing with special dosimetry problems. The book discusses thermoluminescence dosimetry in archeological dating; dosimetric applications of track etching; vacuum chambers of radiation measurement. The text also describes wall-less detectors in microdosimetry; dosimetry of low-energy X-rays; and the theory and general applicability of the gamma-ray theory of track effects to various systems. Dose equivalent determinations in neutron fields by means of moderator techniques; as well as developm

  8. Topics in Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. To start with, chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently

  9. Topics on Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. Chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently coordinate the

  10. Topical report review status: Volume 10

    International Nuclear Information System (INIS)

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published annually

  11. Effects of Preexamination Disclosure of Essay Topics.

    Science.gov (United States)

    Powers, Donald E.; Fowles, Mary E.

    1998-01-01

    To determine the effects on test performance and test validity of releasing essay topics before an examination, 300 prospective graduate students wrote essays on a released and an unreleased topic. Analyses did not reveal any statistically significant effect of topic release. (SLD)

  12. Conclusion from the fifth topic

    International Nuclear Information System (INIS)

    The topic ''mechanics and alteration kinetics of glasses'' is a crucial point for the understanding of the long-term behaviour of nuclear glasses. Kinetic models used in simulation are based on the works made by Grambow who imputes the control of the alteration kinetics of borosilicate glasses to the desorption of the ortho-silica acid produced at the reactive interface. The ensuing kinetics law requires the existence of an equilibrium of the silica at the interface glass/gel and the existence of a linear concentration gradient dissolved in the interstitial gel solution. The role of the gel needs further studies to be well understood. The difficulty lies in the fact that the composition and the structure of the gel varies with time, space (anisotropy) and with the conditions of alteration (temperature, pH, flowrate...). (A.C.)

  13. A method of detecting emerging trends in research topics

    Institute of Scientific and Technical Information of China (English)

    Fei; GE; Zongying; TAN

    2014-01-01

    Purpose:This paper proposes a method of detecting emerging trends in research topics from a more micro perspective.Design/methodology/approach:Through co-word clustering to identify research topics and analyzing position changes of topic words in the keywords life-cycle diagram during different time periods,we detected emerging trends in research topics from a more micro perspective.I’he method was applied to the field of nanotechnology to verify its effectiveness and practicability.Findings:The results show that this method can be used to detect emerging trends in research topics from a more micro perspective,as it divides keywords into five categories:Potential keywords,emerging keywords,hot keywords,stable keywords and recession keywords,through which more details of topic changes can be found.Research limitations:We used keywords provided by authors and database indexers for keywords extraction.But this approach may lead to the problem of "indexer effect".The method may have a limited effect when applied to a disciplinary domain such as mathematics,which evolves slowly.Practical implications:This study provides information analysts with insights into the way to better understand specialty areas of a discipline domain and formulate research policies and strategic plans.Originality/value:This study contributes to the current literature by proposing a new method,which can detect emerging trends in research topics from a more micro perspective.

  14. Topics on the FORM software; Topicos do software FORM

    Energy Technology Data Exchange (ETDEWEB)

    Costa Jorge, Patricia M. da; Peres, Patricia Duarte [Universidade Catolica de Petropolis, RJ (Brazil). Dept. de Ciencia da Computacao

    1997-06-01

    These notes studies the compilation with FORM software as applied to high energy physics, covering the following topics: Command structures, statistics and numbers, Dirac matrices, optimization control, Gamma matrices, errors and polynomial substitution

  15. Topical and working papers on uranium resources and availability

    International Nuclear Information System (INIS)

    Basic topics relative to world-wide resources and availability of uranium resources; potential for recovery of uranium from mill tailings in Canada; uranium from seawater; depleted uranium as an energy source; world uranium requirements in perspective

  16. Preface to Special Topic: Marine Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, F. T.; Iglesias, G.; Santos, P. R.; Deng, Zhiqun

    2015-12-30

    Marine renewable energy (MRE) is generates from waves, currents, tides, and thermal resources in the ocean. MRE has been identified as a potential commercial-scale source of renewable energy. This special topic presents a compilation of works selected from the 3rd IAHR Europe Congress, held in Porto, Portugal, in 2014. It covers different subjects relevant to MRE, including resource assessment, marine energy sector policies, energy source comparisons based on levelized cost, proof-of-concept and new-technology development for wave and tidal energy exploitation, and assessment of possible inference between wave energy converters (WEC).

  17. Topics in multivariate approximation and interpolation

    CERN Document Server

    Jetter, Kurt

    2005-01-01

    This book is a collection of eleven articles, written by leading experts and dealing with special topics in Multivariate Approximation and Interpolation. The material discussed here has far-reaching applications in many areas of Applied Mathematics, such as in Computer Aided Geometric Design, in Mathematical Modelling, in Signal and Image Processing and in Machine Learning, to mention a few. The book aims at giving a comprehensive information leading the reader from the fundamental notions and results of each field to the forefront of research. It is an ideal and up-to-date introduction for gr

  18. Topics in Bayesian statistics and maximum entropy

    International Nuclear Information System (INIS)

    Notions of Bayesian decision theory and maximum entropy methods are reviewed with particular emphasis on probabilistic inference and Bayesian modeling. The axiomatic approach is considered as the best justification of Bayesian analysis and maximum entropy principle applied in natural sciences. Particular emphasis is put on solving the inverse problem in digital image restoration and Bayesian modeling of neural networks. Further topics addressed briefly include language modeling, neutron scattering, multiuser detection and channel equalization in digital communications, genetic information, and Bayesian court decision-making. (author)

  19. Recent topics in differential and analytic geometry

    CERN Document Server

    Ochiai, T

    2014-01-01

    Advanced Studies in Pure Mathematics, Volume 18-I: Recent Topics in Differential and Analytic Geometry presents the developments in the field of analytical and differential geometry. This book provides some generalities about bounded symmetric domains.Organized into two parts encompassing 12 chapters, this volume begins with an overview of harmonic mappings and holomorphic foliations. This text then discusses the global structures of a compact Kähler manifold that is locally decomposable as an isometric product of Ricci-positive, Ricci-negative, and Ricci-flat parts. Other chapters con

  20. Topicality and Social Impact: Diverse Messages but Focused Messengers

    OpenAIRE

    Weng, Lilian; Menczer, Filippo

    2014-01-01

    Are users who comment on a variety of matters more likely to achieve high influence than those who delve into one focused field? Do general Twitter hashtags, such as #lol, tend to be more popular than novel ones, such as #instantlyinlove? Questions like these demand a way to detect topics hidden behind messages associated with an individual or a hashtag, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags by detecting communi...