WorldWideScience

Sample records for biography as topic

  1. Athletes confessions: the sports biography as an interaction ritual

    OpenAIRE

    Thing, Lone Friis; Ronglan, Lars Tore

    2014-01-01

    Commercialization of emotions is not a new phenomenon but in Denmark there is a new general trend to tell and sell personal stories in the media. Personal deprivation and crises are also major topics in sports media. This paper focuses on sports biographies as a book genre that is reviving in popularity. The paper approaches the topic through the biographies of one Danish athlete: the former professional cyclist, Jesper Skibby, who writes about his doping disclosure and shares his personal di...

  2. Magnus Hirschfeld, his biographies and the possibilities and boundaries of "biography" as "doing history.".

    Science.gov (United States)

    Brennan, Toni; Hegarty, Peter

    2009-12-01

    This article considers the two major biographies of sexologist Magnus Hirschfeld, MD (1868-1935), an early campaigner for "gay rights" avant la lettre. Like him, his first biographer Charlotte Wolff (1897-1986) was a Jewish doctor who lived and worked in Weimar Republic Berlin and fled Germany when the Nazi regime came to power. When researching Hirschfeld's biography (published in English in 1986) Wolff met a librarian and gay activist, Manfred Herzer, who would eventually be a cofounder of the Gay Museum in Berlin and publish (in German, in 1992) the other major Hirschfeld biography currently available. Using, inter alia, the correspondence between Wolff and Herzer, the article aims to explore and interrogate the boundaries and possibilities of "biography" as a form of "doing history."

  3. Athletes confessions: the sports biography as an interaction ritual.

    Science.gov (United States)

    Thing, L F; Ronglan, L T

    2015-04-01

    Commercialization of emotions is not a new phenomenon but in Denmark there is a new general trend to tell and sell personal stories in the media. Personal deprivation and crises are also major topics in sports media. This paper focuses on sports biographies as a book genre that is reviving in popularity. The paper approaches the topic through the biographies of one Danish athlete: the former professional cyclist, Jesper Skibby, who writes about his doping disclosure and shares his personal dilemmas as a former elite sportsman. The thematic text analysis orientates around social interactions, emotions, and personality constructions. Inspired by microsociology with a Durkheimian flavor of Goffman and Hochschild, themes including "face work," "interaction rituals," and "emotions management" are discussed. The analysis claims that sharing personal information in the media is not only a means of confession and reclaiming status but is also business and management - on an intimate level. Telling the story of the corrosion of a sporting character has become a hot issue, an entertainment, and not least a commercial commitment.

  4. Comparative Biography as Political History: Huey Long and Father Coughlin.

    Science.gov (United States)

    Brinkley, Alan

    1984-01-01

    Comparing the biographies of individuals is a technique that can be used to illuminate the larger history of a society. As an illustration, comparative biographies of two dissident leaders, Huey Long and Father Charles Coughlin, are discussed to show how they reflect the social and political history of the 1930s. (RM)

  5. Historical "Bad Guys": Biography as a Teaching Tool.

    Science.gov (United States)

    Dietrich, Donald J.

    1987-01-01

    Describes a history course on the college level that uses biographies to help students connect important political leaders, such as Hitler and Machiavelli, to the time and place that shaped their actions. Reports on the effectiveness of the class. (RKM)

  6. Biography as an Art: Selected Criticism 1560-1960.

    Science.gov (United States)

    Clifford, James L., Ed.

    Forty-seven essays from five centuries of writings on biography are contained in this book. Selections are arranged under the following headings: "Before 1700" (9 selections), "The Eighteenth Century" (5), "The Nineteenth Century" (11), "Early Twentieth Century" (14), and "Mid-Twentieth Century" (8). Authors range from Francis Bacon to Leon Edel.…

  7. Topical peptides as cosmeceuticals

    Directory of Open Access Journals (Sweden)

    Varadraj Vasant Pai

    2017-01-01

    Full Text Available Peptides are known to have diverse biological roles, most prominently as signaling/regulatory molecules in a broad variety of physiological processes including defense, immunity, stress, growth, homeostasis and reproduction. These aspects have been used in the field of dermatology and cosmetology to produce short, stable and synthetic peptides for extracellular matrix synthesis, pigmentation, innate immunity and inflammation. The evolution of peptides over the century, which started with the discovery of penicillin, has now extended to their usage as cosmeceuticals in recent years. Cosmeceutical peptides may act as signal modulators of the extracellular matrix component, as structural peptides, carrier peptides and neurotransmitter function modulators. Transdermal delivery of peptides can be made more effective by penetration enhancers, chemical modification or encapsulation of peptides. The advantages of using peptides as cosmeceuticals include their involvement in many physiological functions of the skin, their selectivity, their lack of immunogenicity and absence of premarket regulatory requirements for their use. However, there are disadvantages: clinical evidence for efficacy is often weak, absorption may be poor due to low lipophilicity, high molecular weight and binding to other ingredients, and prices can be quite high.

  8. Arnold Hauser - a biography

    DEFF Research Database (Denmark)

    Larsen, Mihail

    It seems reasonable to regard Arnold Hauser's own biography in three different stories. First an official one, dealing with his public appearance through his publications. Another story has to be told about his personal life concentrating on his relationships with other intellectuals important...... to his biography. The last story deals with his self-estimation as an intellectual in a modern society....

  9. Portraits: Biography and Autobiography in the Secondary School.

    Science.gov (United States)

    Fleming, Margaret, Ed.; McGinnis, Jo, Ed.

    Prepared by experienced classroom teachers from all levels, the articles in this book explain how to use biography and autobiography as a basis for the thorough study of a topic in literature, history, the social sciences, or other subject areas. The nine articles in the first section of the book use Maya Angelou's "I Know Why the Caged Bird…

  10. Difficulties of Biography Writing: A Philosophical Approach

    OpenAIRE

    Vefa TAŞDELEN

    2014-01-01

    In this article can be also entitled “Difficulties of Biography Writing: A Philosophical Approach” what biography and biography writing means will be dealt with from a partly existentialist and hermeneutic view point by taking questions such as; “what is biography?”, “why human beings want to understand the other?”, “what is the nature of biography: is it history or literature?” into consideration. In this respect; knowledge value, art value, ethical value, existential value and educational v...

  11. Identity and Biography as Mediators of Science and Mathematics Faculty's Involvement in K-12 Service

    Science.gov (United States)

    Skerrett, Allison; Sevian, Hannah

    2010-01-01

    This article explores aspects of science and mathematics faculty identities and biographies that mediated their involvement in K-12 service. Faculty expressed five motivations for participating in K-12 service--advancing their research agenda, advocating environmental consciousness, desiring to be involved in their children's schools, aspiring to…

  12. Topical and peripheral ketamine as an analgesic.

    Science.gov (United States)

    Sawynok, Jana

    2014-07-01

    Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this provided the initial impetus for exploring peripheral applications of ketamine. Ketamine also produces several other pharmacological actions (block of ion channels and receptors, modulation of transporters, anti-inflammatory effects), and while these may require higher concentrations, after topical (e.g., as gels, creams) and peripheral application (e.g., localized injections), local tissue concentrations are higher than those after systemic administration and can engage lower affinity mechanisms. Peripheral administration of ketamine by localized injection produced some alterations in sensory thresholds in experimental trials in volunteers and in complex regional pain syndrome subjects in experimental settings, but many variables were unaltered. There are several case reports of analgesia after topical application of ketamine given alone in neuropathic pain, but controlled trials have not confirmed such effects. A combination of topical ketamine with several other agents produced pain relief in case, and case series, reports with response rates of 40% to 75% in retrospective analyses. In controlled trials of neuropathic pain with topical ketamine combinations, there were improvements in some outcomes, but optimal dosing and drug combinations were not clear. Given orally (as a gargle, throat swab, localized peritonsillar injections), ketamine produced significant oral/throat analgesia in controlled trials in postoperative settings. Topical analgesics are likely more effective in particular conditions (patient factors, disease factors), and future trials of topical ketamine should include a consideration of factors that could predispose

  13. Exhibiting Mozart: Rethinking Biography

    OpenAIRE

    Spring, Ulrike

    2010-01-01

    Abstract: The article analyses the new permanent exhibition in the composer Wolfgang A. Mozart’s apartment in Vienna, opened in 2006, from the curator’s perspective. The exhibition presents an approach to biographical display in which the exhibited person becomes part of a multifaceted web of contexts, and the article argues for the active deployment of the polysemic character of objects as a means of grasping the complexity of a person’s biography. Presenting a concept for the...

  14. Freud and Literary Biography.

    Science.gov (United States)

    Ellman, Richard

    1984-01-01

    Sigmund Freud's attitudes about writing biographies of authors, and the influence of Freud's work on the interpretations of creativity, are discussed in relation to biographies of and by a number of writers. It is proposed that Freud's contributions, used carefully, have served to enlighten biography. (MSE)

  15. The biography of scientists as a means of communicating science: analogies concerning a hermeneutic or empirical problem

    Directory of Open Access Journals (Sweden)

    Maria Francisca Carneiro

    2007-10-01

    Full Text Available Sometimes scientists live real dramas or undergo social and psychological conflicts which have a positive or negative influence on the development and recognition of their research, discoveries and inventions in society, including the way they are recorded in history. This being so, the question is: to what extent can science be communicated to the public at large by the use of scientists' biographies as a motivational strategy? The controversy arises from the fact that usual (classical science has traditionally argued for the separation (or de-linking of the research (the object from the researcher (the subject.Thus, if the above-mentioned motivational strategy is used in scientific communication, it could break a dominant methodological trend and consequently lead to a questioning of the myth of axiological neutrality in science. The communication of science by means of scientists' biographies could be useful for reaching a specific public, more directed towards emotional aspects, thereby awakening its interest in science, even amid cultural differences and in environments where interest in science and its utility is lacking. It could also reveal human aspects of the everyday life of scientists, bringing them closer to the public at large, which would contribute to the dissemination of science and knowledge.

  16. Towards a Poetics of Literary Biography

    Science.gov (United States)

    Benton, Michael

    2011-01-01

    Writing biography, as writing any historical account, "involves the use of literary techniques and is subject to aesthetic requirements in both style and structure." Narrative, common to both historical and fictional writing, is the central theoretical concept; and understanding the nature of narrative in biography--a hybrid genre that is grounded…

  17. Prosopagnosia in biographies and autobiographies.

    Science.gov (United States)

    Grüter, Thomas; Grüter, Martina

    2007-01-01

    Prosopagnosia is a selective impairment of the visual learning and recognition of faces. The congenital type, which is not accompanied by detectable brain damage or malformation, was recently found to be far more common than previously known. Therefore, one should expect that at least a few biographies or autobiographies would reveal a prosopagnosia. In this paper we present an autobiography and a biography describing five cases of congenital prosopagnosia. These biographic descriptions of prosopagnosia add further evidence to the assumption that the congenital type of prosopagnosia is not a rare condition, and not as socially crippling as one might expect.

  18. Social Biography and Research.

    Science.gov (United States)

    Crepeau, Elizabeth Blesedell

    1997-01-01

    A researcher's life experiences cannot help but influence the research process. Including elements of one's social biography in research reports helps readers identify how a researcher's history and biases shaped the study. (SK)

  19. Aging According to Biography.

    Science.gov (United States)

    Weiland, Steven

    1989-01-01

    Uses Erik Erikson's work to discuss how biographies treat aging. Explores how developmental theorists observe biographical representations of the life cycle and its applicability to aging. (Author/BHK)

  20. [Biography as discipline tradition. The idealization of the pharmacologist Wolfgang Heubner (1877-1957)].

    Science.gov (United States)

    Kessel, Nils

    2008-01-01

    Taking a german professor of pharmacology, Wolfgang Heubner (1877-1957), as an example, the paper shows how hagiographic traditions were used to construct a scientific ideal in Post-War Germany. This ideal tended to (re-)legitimate German Science after World War II and to justify institutional and personal continuities in the 1950s, but I argue that it is a specific construction of the 1950s, thus serving to build a new image of science in a democratic society.

  1. Deterritorializing Collective Biography

    Science.gov (United States)

    Gannon, Susanne; Walsh, Susan; Byers, Michele; Rajiva, Mythili

    2014-01-01

    This paper proposes a new move in the methodological practice of collective biography, by provoking a shift beyond any remnant attachment to the speaking/writing subject towards her dispersal and displacement via textual interventions that stress multivocality. These include the use of photographs, drama, and various genres of writing. Using a…

  2. African-American Biography.

    Science.gov (United States)

    Martin, Ron

    1995-01-01

    Suggests sources of information for African American History Month for library media specialists who work with students in grades four through eight. Gale Research's "African-American Reference Library," which includes "African-America Biography,""African-American Chronology," and "African-American Almanac,"…

  3. Pentyl Gallate Nanoemulsions as Potential Topical Treatment of Herpes Labialis.

    Science.gov (United States)

    Kelmann, Regina G; Colombo, Mariana; De Araújo Lopes, Sávia Caldeira; Nunes, Ricardo J; Pistore, Morgana; Dall Agnol, Daniele; Rigotto, Caroline; Silva, Izabella Thais; Roman, Silvane S; Teixeira, Helder F; Oliveira Simões, Cláudia M; Koester, Letícia S

    2016-07-01

    Previous studies have demonstrated the antiherpes activity of pentyl gallate (PG), suggesting that it could be a promising candidate for the topical treatment of human herpes labialis. PG low aqueous solubility represents a major drawback to its incorporation in topical dosage forms. Hence, the feasibility of incorporating PG into nanoemulsions, the ability to penetrate the skin, to inhibit herpes simplex virus (HSV)-1 replication, and to cause dermal sensitization or toxicity were evaluated. Oil/water nanoemulsions containing 0.5% PG were prepared by spontaneous emulsification. The in vitro PG distribution into porcine ear skin after topical application of nanoemulsions was assessed, and the in vitro antiviral activity against HSV-1 replication was evaluated. Acute dermal toxicity and risk of dermal sensitization were evaluated in rat model. Nanoemulsions presented nanometric particle size (from 124.8 to 143.7 nm), high zeta potential (from -50.1 to -66.1 mV), loading efficiency above 99%, and adequate stability during 12 months. All formulations presented anti-HSV-1 activity. PG was able to reach deeper into the dermis more efficiently from the nanoemulsion F4. This formulation as well as PG were considered safe for topical use. Nanoemulsions seem to be a safe and effective approach for topically delivering PG in the treatment of human herpes labialis infection.

  4. Biography as an art form: the story of Helen Flanders Dunbar, M.D., Ph.D., B.D., and Med. Sci. D.

    Science.gov (United States)

    Hart, Curtis W

    2014-06-01

    Helen Flanders Dunbar (1902-1959) was a physician, medieval and Renaissance scholar, theologian, and founder of the American Psychosomatic Society and its journal Psychosomatic Medicine. Her contributions are not currently well known but deserve recognition from all those involved or interested in the dialogue between medicine and spirituality. This essay explores Dunbar's personal history and professional achievements. It focuses particular attention on a feminist perspective regarding her life and work. It will conclude with a discussion of how biography, as an art form, transforms both author and audience. This essay was originally presented as the Second Annual J.R. Williams Memorial Lecture on Spirituality and Medicine at the Tulane School of Medicine in fall 2013.

  5. Topical dexketoprofen as a cause of photocontact dermatitis.

    Science.gov (United States)

    López-Abad, R; Paniagua, Ma J; Botey, E; Gaig, P; Rodriguez, P; Richart, C

    2004-01-01

    We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketoprofen and piketoprofen are non-steroidal anti-inflamatory drugs (arylpropionic acid derivatives) often used as topical anti-inflammatory agents. It appears that the benzophenone moiety of their chemical structure is the cause of their photosensitivity and cross-photoreaction.

  6. The universe a biography

    CERN Document Server

    Gribbin, John

    2008-01-01

    The Universe: A Biography makes cosmology accessible to everyone. John Gribbin navigates the latest frontiers of scientific discovery to tell us what we really know about the history of the universe. Along the way, he describes how the universe began; what the early universe looked like; how its structure developed; and what emerged to hold it all together. He describes where the elements came from; how stars and galaxies formed; and the story of how life emerged. He even looks to the future: is the history of the universe going to end with a Big Crunch or a Big Rip.

  7. Topical tranexamic acid as a promising treatment for melasma

    Science.gov (United States)

    Ebrahimi, Bahareh; Naeini, Farahnaz Fatemi

    2014-01-01

    Background: In recent times, tranexamic acid (TA) is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI) and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12. Results: A repeated measurement analysis was used to evaluate the changes in the MASI score before and after treatments. A significant decreasing trend was observed in the MASI score of both groups with no significant difference between them during the study (P < 0.05). No differences were seen in patients’ and investigator's satisfaction of melasma improvement between two groups (P < 0.05). However, the side effects of hydroquinone + dexamethasone were significantly prominent compared with TA (P = 0.01). Conclusion: This study's results introduce the topical TA as an effective and safe medication for the treatment of melasma. PMID:25422661

  8. Topical tranexamic acid as a promising treatment for melasma

    Directory of Open Access Journals (Sweden)

    Bahareh Ebrahimi

    2014-01-01

    Full Text Available Background: In recent times, tranexamic acid (TA is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12. Results: A repeated measurement analysis was used to evaluate the changes in the MASI score before and after treatments. A significant decreasing trend was observed in the MASI score of both groups with no significant difference between them during the study (P < 0.05. No differences were seen in patients′ and investigator′s satisfaction of melasma improvement between two groups (P < 0.05. However, the side effects of hydroquinone + dexamethasone were significantly prominent compared with TA (P = 0.01. Conclusion: This study′s results introduce the topical TA as an effective and safe medication for the treatment of melasma.

  9. Albert Einstein a biography

    CERN Document Server

    Fölsing, Albrecht

    1997-01-01

    Albert Einstein's achievements are not just milestones in the history of science; decades ago they became an integral part of the twentieth-century world in which we live. Like no other modern physicist he altered and expanded our understanding of nature. Like few other scholars, he stood fully in the public eye. In a world changing with dramatic rapidity, he embodied the role of the scientist by personal example. Albrecht Folsing, relying on previously unknown sources and letters, brings Einstein's "genius" into focus. Whereas former biographies, written in the tradition of the history of science, seem to describe a heroic Einstein who fell to earth from heaven, Folsing attempts to reconstruct Einstein's thought in the context of the state of research at the turn of the century. Thus, perhaps for the first time, Einstein's surroundings come to light.

  10. Solar thermal energy as a topic in secondary mathematics classrooms

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, A.; Brinkmann, K. [EnviPro Environmental Process Engineering Prof. Dr. Klaus Brinkmann, Iserlohn (Germany)

    2004-07-01

    One of the most effective methods to achieve a sustainable change of our momentary existing power supply system to a system mainly based on renewable energy conversion is the education of our children. For this purpose the compulsory school subject mathematics appears to be suitable. In order to promote renewable energy issues in mathematics classrooms, the authors have developed a special didactical concept to open this field for students, as well as for their teachers. The aim of this paper is to present firstly an overview of our concept and secondly examples of problems to the special topic of solar thermal energy, developed on the basis of our concept. (orig.)

  11. Re-Writing Composers’ Lives: Critical Historiography and Musical Biography

    OpenAIRE

    Wiley, Christopher

    2008-01-01

    Recent musicological discourse, while frequently considering issues of historiography and canonicity, has seldom critically engaged with biography as a genre of documentary significance to reception history for its attempts to shape public opinion of its subjects. In consequence, modern musicology has often taken for granted many tendencies and preoccupations that accumulated in musical biography in the late nineteenth and early twentieth centuries. This thesis presents a histo...

  12. The possibilities and limitation of transcultural biography work: Lithuanian case

    Directory of Open Access Journals (Sweden)

    Zemaitaityte I.

    2014-01-01

    Full Text Available Lithuania, as well as other contemporary societies, is undergoing the times full of new technological, political, economic, social and scientific changes. In the changing society, adult education has helps a person to develop his and her cultural interests, creative powers, skills and acquire theoretical knowledge necessary for person's professional activity, enables a person to upgrade his or her current qualification and helps to become an active citizen of a democratic society (Zemaitaityte, 2007. This paper seeks to discuss Trancultural Biography Work (TBW as an adult educative approach that is mainly oriented on one's resources and potentials. But it also may help to overcome hindering patterns of thinking, feeling and acting. Through Biography Work, people explore how they handled difficult situations in one's life: How did the person manage similar situations in the past? How did other people or other members of person family with whom he/she shared memory manage it? It supports to gain self-awareness as well as courage and the desire to realize one's potentials. “Realize. Transcultural Biography Work for Adult Education” international project, from 2010 to 2012, was dedicated to apply Transcultural Biography Work (TBW in different counties and contexts with different participants with various needs and backgrounds, explore and implement new techniques of Transcultural Biography Work, assess the effectiveness of TBW techniques, and elaborate further on Transcultural Biography Work approach.

  13. The many lives of Charles Darwin: early biographies and the definitive evolutionist.

    Science.gov (United States)

    Lightman, Bernard

    2010-12-20

    This article focuses on the early book-length biographies of Darwin published from his death in 1882 up to 1900. By making 1900 the cutoff point I can examine the biographies produced when the iconic figure was not yet set in stone, and before the rediscovery of Mendel's work in the early twentieth century and the anniversary celebrations of 1909 changed the way in which Darwin was regarded. Darwin's biographers dealt with three major themes. First, several biographers emphasized his scientific abilities, in particular his powers of observation and his prowess in conducting experiments. Second, many biographers discussed his character, a key issue in determining whether or not he could be trusted as a scientific guide. Finally, his scientific theories and religious beliefs, and how they related to the evolutionary controversy, formed a topic taken up by most biographers. By focusing on these three themes, the biographies published before 1900 were important in shaping the image of Darwin that was forming in American and British culture.

  14. [The national biography - a comprehensive research project].

    Science.gov (United States)

    Makela-Alitalo, A

    1998-01-01

    This project was initiated by the Finnish Historical Society in 1993. The reason was an increasing interest in biographies. The aim is to write 6000 Finnish biographies in 11-12 volumes. The articles are planned to be published in the beginning of the year 2000. Selected historical characters from the Middle Ages to the present day are to be described. The most influential persons in politics, economy and the church as well as in art and sport are presented in articles of 20-30 pages. Certain persons representing the economy of life of previous times are presented in shorter articles as examples of the circumstances of their days. In addition extraordinary characters considered to be of special interest to the readers are introduced. The border between the groups is indistinct. The witches from the 17th Century are, for example, both typical representatives of their time and exceptional persons as seen by modern people. Similarities between old magic and modern "alternative" medicine are also obvious. An object of special interest is women's history, which previously has been almost overlooked. Female biographies now constitute about 15% of the articles. The National Biography is also available as a net version. The first articles were opened in late 1997 in the Internet. In the field of medical science, all the most prominent persons in the history of medicine and related professions are included, beginning from the king's physician Johan Copp in the 16th century. The medical profession is extended so as to consist of university professors and scientists, practitioners and promotors of administration as well as healers.

  15. Topical fluoride as a cause of dental fluorosis in children

    OpenAIRE

    Wong, MCM; Lo, ECM; Glenny, AM; Tsang, BWK; Worthington, HV; Marinho, VCC

    2009-01-01

    BACKGROUND: For many years, topical use of fluorides has gained greater popularity than systemic use of fluorides. A possible adverse effect associated with the use of topical fluoride is the development of dental fluorosis due to the ingestion of excessive fluoride by young children with developing teeth. OBJECTIVES: To describe the relationship between the use of topical fluorides in young children and the risk of developing dental fluorosis. SEARCH STRATEGY: Electronic search of the Cochra...

  16. [Environmental history as an anthropologic topic. Contribution to "chemical anthropology"].

    Science.gov (United States)

    Grupe, G

    1990-06-01

    Human population history is firmly connected with temporal and regional changes of the environment. Whether natural or anthropogene, alteration of environmental features lead to changes of human life-style and to the development of adaptive strategies. The demand of resources for his subsistence has led man to diverse impacts on his environment since ever. Thus, environmental history is a scientific topic for anthropologists. The research potential of trace element studies of excavated human skeletons for the reconstruction of natural and socio-cultural environments as well as for distribution patterns of hazardous substances is outlined for the European Middle Ages. The scientific value of unravelling past man/environment-interrelationships for both the historical and applied sciences and the place of any "chemical anthropology" within this context is discussed.

  17. TOPICAL IMMUNIZATION AND THE USE OF CHITOSAN AS CARRIER

    Directory of Open Access Journals (Sweden)

    Vengadesh prabhu K

    2011-02-01

    Full Text Available With the technological advances in biomedical sciences and the better understanding of how the immune system works, new immunisation strategies and vaccine delivery options, such sprays, patches, and edible formulations have been developed. Needle-free delivery of vaccines has become a global priority. Transcutaneous immunisation (TCI, topical application of vaccine antigens to the skin, can elicit systemic antibody and T-cell responses, suggesting that this new technique may provide a means for vaccination without needles. TCI requires the use of an adjuvant such as cholera toxin added to a vaccine antigen, such as diphtheria toxoid, to induce antibodies to diphtheria toxoid. The adjuvant and antigen are thought to target Langerhans cells, potent antigen-presenting cells found in the superficial layers of the skin. TCI appears to be a highly practical technique for delivery of vaccines that provides unique access to the immune system.

  18. Elastic vesicles as topical/transdermal drug delivery systems.

    Science.gov (United States)

    Choi, M J; Maibach, H I

    2005-08-01

    Skin acts a major target as well as a principle barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been assessed to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Elastic vesicles are classified with phospholipid (Transfersomes((R)) and ethosomes) and detergent-based types. Elastic vesicles were more efficient at delivering a low and high molecular weight drug to the skin in terms of quantity and depth. Their effectiveness strongly depends on their physicochemical properties: composition, duration and application volume, and entrapment efficiency and application methods. This review focuses on the effect of elastic liposomes for enhancing the drug penetration and defines the action mechanism of penetration into deeper skin.

  19. Sylvia Plath and the Dangers of Biography

    Directory of Open Access Journals (Sweden)

    Selma Asotić

    2015-09-01

    Full Text Available 2013 marked the 50th anniversary of the death of Sylvia Plath and was commemorated by a flurry of new publications on the life and work of the late poet. The renewed interest in Sylvia Plath also revitalized the decades-old debate on the interdependence of her poems and her biography. This paper investigates and problematizes the way in which poetry in general and the work of Sylvia Plath in particular are read and interpreted. It tries to shed some light on the “biographical fallacy” which has for so long plagued critical approaches to her work and shows ways in which S. Plath’s own poetic method differs from the method of confessional writers such as Robert Lowell, in the hope of revealing why S. Plath’s work cannot and should not be approached through the prism of her biography.

  20. Julius Petersen 1839-1910. A Biography

    DEFF Research Database (Denmark)

    Lützen, Jesper; Sabidussi, Gert; Toft, Bjarne

    1992-01-01

    A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics.......A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics....

  1. Review of topical beta blockers as treatment for infantile hemangiomas.

    Science.gov (United States)

    Painter, Sally L; Hildebrand, Göran Darius

    2016-01-01

    The treatment of infantile hemangiomas changed from the use of oral corticosteroids to oral propranolol on the serendipitous discovery of propanolol's clinical effectiveness in 2008. Since then, clinicians have begun to use topical beta blockers--in particular, timolol maleate 0.5% gel forming solution--with good effect. Topical beta blockers are now used for lesions with both deep and superficial components and those that are amblyogenic. When initiated in the proliferative phase of the lesion, the effectiveness of the treatment can be seen within days. There is no consensus on dosing, treatment bioavailability, or clinical assessment of lesions, but these are topics for future research.

  2. Trois biographies de Juan Rulfo

    OpenAIRE

    2014-01-01

    L’article s’intéresse à la fortune éditoriale des biographies de Rulfo à l’occasion de la célébration des cinquante ans de la parution de El llano en llamas (1953) et de Pedro Páramo (1955). L’étude de trois d’entre elles (écrites par Nuria Amat, Reina Roffé et Juan Ascensio) permet de voir le processus de légitimation de la biographie et les positions qu’adoptent les différents auteurs (tout spécialement en ce qui concerne leur relation avec l’auteur “biographié”) Les auteurs justifient leur...

  3. Ethnomusicological biography of the traditional folk musician: Biography of the gusle-player

    Directory of Open Access Journals (Sweden)

    Lajić-Mihajlović Danka

    2008-01-01

    Full Text Available With the development of ethnomusicology from a comparative discipline to an anthropologically oriented science there has been an increase in the significance of the biography of folk musicians as scientific sources. The intention of the anthropological thought to accept and theoretically consider human nature as open and dynamic, has been realized in the ethnomusicological plane through the understanding of music as a product of thinking and behaviour of a particular musician in given circumstances. The concept of an artist is especially complex in the field of oral music culture, where creation and performance are connected in one person and the transferring process involves direct communication. The attempt to overcome the dichotomy of the musicological and sociological, i. e. anthropological attitude in ethnomusicology by synthesizing concepts which involve music, culture and man has brought particular importance to the relations between individual biographies and 'biographies of the collective' - relevant historical ethnological, anthropological, sociological, culturological, religion ideological and other types of data. Observations enlightening the social side of the folk musician's personality make the necessary 'frame' for the biography: from 'objective' social circumstances which modelled it to the opinion of the cultural environment about his performing. The folk musician's biography oriented towards ethnomusicology involves the result of a critical evaluation of the picture based on the emic and ethic vision autobiographical data and the observations of others, primarily researchers. The complexity of a biographical discourse in ethnomusicology can be perfectly seen in the example of the gusle-player's biography, as a genre-determined solo role in the tradition. For studying the relation between a person and a style of music expression, concerning gusle-players it is important to bear in mind the change in the profile of gusle

  4. Telling Lives in Science: Essays on Scientific Biography

    Energy Technology Data Exchange (ETDEWEB)

    Harman, Peter

    1997-09-01

    This collection of ten essays by historians of science, several of them biographers, is concerned with the role of scientific biography in forming conceptions of science and scientists. The essays include studies of the biographies of individual scientists, assessments of the aims and style of scientific portraits in different historical contexts, examinations of changing biographical interpretations of scientists, and much discussion of the methodological issues involved in the writing of scientific biographies. Many historians consider biography to be an ambiguous genre, its appeal based on nostalgia rather than history, with a focus on personality rather than historical context, but the biographer can reply that scientific biography reveals the practice of science at its most fundamental level. Indeed, scientific biography has provided a powerful medium in which public conceptions of science have been established. Einstein observed that 'the essential being of a man of my type lies in what he thinks and how he thinks', and his Autobiographical Notes suppress personality in favour of physics. But the biographer may see matters differently, and wish to integrate the public and the private life of the scientist. In their substantial introduction the editors discuss these and other problems, and the book is directed to the professional concerns of historians of science. While there is little here on the history of physics, Geoffrey Cantor's essay on public images of Faraday as constructed in popular biographies, a discussion of conflicting portraits of Faraday as romantic genius or hard-working slogger, may interest readers of this journal. (book review)

  5. Whey protein stories - An experiment in writing a multidisciplinary biography.

    Science.gov (United States)

    Jensen, Tenna; Bechshoeft, Rasmus L; Giacalone, Davide; Otto, Marie Haulund; Castro-Mejía, Josue; Bin Ahmad, Hajar Fauzan; Reitelseder, Søren; Jespersen, Astrid Pernille

    2016-12-01

    This is an experimental, dual-purpose article about whey protein and how to conduct interdisciplinary analyses and writings. On the one hand, this article is a multidisciplinary commodity biography, which consists of five descriptions of whey protein written by the five different research groups involved in the interdisciplinary research project CALM(Counteracting Age-related loss of Skeletal Muscle Mass). On the other hand, it is a meta-analysis, which aims to uncover and highlight examples of how the five descriptions contribute to each other with insights into the contextualisation of knowledge, contrasts between the descriptions and the new dimensions they bring to established fields of interest. The meta-analysis also contains a discussion of interdisciplinary study objects and the usefulness of the multidisciplinary commodity biography as a format for interdisciplinary publications. The article contributes to the field of food studies with a multidisciplinary biography of whey protein - including its sensory qualities and challenges, insights into its cultural history, its nutritional value and effects on the human body and an analysis of how it is perceived by people who consume it. The biography thereby expands upon existing understandings of whey protein while discussing the usefulness of employing the commodity biography format in interdisciplinary writing. Moreover, the article contributes to the field of interdisciplinary research by providing a practical example of a joint publication and reflections upon the existence, interaction and possibilities of monodisciplinary knowledge structures within interdisciplinary studies and publications.

  6. Portraits in medical biography: Alexander Pope (1688-1744), poet, patient, celebrity.

    Science.gov (United States)

    James, Douglas

    2013-11-01

    Portraits are underused in the medical biographies of patients, yet they can illuminate health concerns and even health itself in many ways. Tying portraiture and medicine together analytically yields many insights into Pope's medical biography - from his response to satirical ridicule to his friends' concern for his health - without abandoning his portraits as works of 'art'.

  7. Guiding Inquiry with Biography Breaks and the C3 Framework: Can One Person Make a Difference?

    Science.gov (United States)

    Young, Terrell A.; Miner, Amy Baird

    2015-01-01

    The purpose of this article is to explore how teachers can use biography breaks to address the National Council of the Social Studies C3 inquiry framework and in the process meet requirements of the Common Core State Standards. We begin by illustrating and explaining biography breaks. Then we introduce the C3 framework and explain as well as…

  8. On the Psychological Plausibility of "Topic" as a Construct in Research on Writing.

    Science.gov (United States)

    Nunan, David

    1994-01-01

    A study investigated the importance of sentence topic in written discourse. Training second language writers to identify sentence topics in drafts of their written work has been proposed as a central means of helping writers achieve greater coherence. The study explored the notion that "topic" is a psychological rather than linguistic concept, and…

  9. Complementary Therapies for Idiopathic Hirsutism: Topical Licorice as Promising Option

    Directory of Open Access Journals (Sweden)

    Gita Faghihi

    2015-01-01

    Full Text Available Hirsutism is one of the most prevalent health problems in women. The aim of the study was to compare the effect of 755 nm alexandrite hair removal laser with that of alexandrite laser plus topical licorice on the improvement of idiopathic hirsutism. A double-blind, randomized placebo-controlled study was performed on 90 female subjects. The patients were divided into two groups: alexandrite laser plus 15% licorice gel (group A and placebo (group B. Each subject received one of both products over one side of the face, twice daily for 24 weeks on the hirsute locations. Each group underwent five sessions of alexandrite laser at 6-week intervals. To minimize the effects of confounding variables, the test was performed on two separate zones of patients’ skin. The mean ± SD numbers of terminal hairs in group A were 7.05 ± 4.55 for zone 1 and 6.06 ± 3.70 for zone 2. In group B, they were 3.18 ± 1.75 for zone 1 and 2.49 ± 1.63 for zone 2. The difference in the mean number of terminal hairs was statistically significant between the two groups (p<0.001, and there were no serious adverse reactions. The treatment of idiopathic hirsutism with 755 nm alexandrite laser plus topical licorice is more effective than alexandrite laser only.

  10. Gauß eine Biographie

    CERN Document Server

    Mania, Hubert

    2009-01-01

    Daniel Kehlmann hat ihn wiederentdeckt, den bedeutendsten Mathematiker der Neuzeit: Karl Friedrich Gauß (1777 1855). Seine überragenden wissenschaftlichen Leistungen waren schon seinen Zeitgenossen bewusst. Da Gauß jedoch nur einen Bruchteil seiner Entdeckungen veröffentlichte, erschloss sich erst der Nachwelt die Tiefgründigkeit und Reichweite seines Werks. Hubert Mania schildert in dieser ersten umfassenden Biographie die Geschichte eines genialen Wissenschaftlers und zugleich eine ganze Epoche. Gauß war ein Mann, der in einer Welt des Aufbruchs völlig zurückgezogen lebte. Dabei hat er wie kaum ein anderer unsere Sicht der Welt revolutioniert. Als Erster formulierte er eine nichteuklidische Geometrie und schuf damit die unentbehrliche Grundlage zu Einsteins Entwicklung der allgemeinen Relativitätstheorie. Eine glänzend geschriebene Biographie des weltberühmten und doch so unbekannten Genies Karl Friedrich Gauß.

  11. Notes on the Method of World-System Biography

    Directory of Open Access Journals (Sweden)

    Kevan Harris

    2015-08-01

    Full Text Available C. Wright Mills boiled the social sciences down to one sentence: “They are attempts to help us understand biography and history, and the connections between the two in a variety of social structures.” This special issue considers biography as an fruitful entry point into macro-historical sociology. With lineages from Marx and Weber to Wallerstein and Bourdieu, the sociology of the individual can produce a clearer path between the muddy oppositions of structure and agency or the longue durée and the event. This special issue unbinds biography from methodological nationalism and the teleology of great men tales. Instead, we aim to show how individuals are "a world within a world," an acting subject structured within world historical time and place.

  12. Olive Banks and the Collective Biography of British Feminism

    Science.gov (United States)

    Weiner, Gaby

    2008-01-01

    This paper considers Olive Banks' work on charting the history and development of British feminism, and particularly her use of collective biography as a research and analytic tool. It is argued that while this has been seen as the least "fashionable" aspect of her work, it took forward C. Wright Mills' contention for one definition of…

  13. "It is Hard Fun": Scaffolded Biography Writing with English Learners

    Science.gov (United States)

    Pavlak, Christina M.

    2013-01-01

    Using Systemic Functional Linguistics (SFL) as a theoretical framework, a team of university staff and educators at a traditionally under-performing urban elementary school built a collaboration aimed at enhancing writing instruction. The current qualitative research study, which was part of this larger project, focused on biography writing in Eva…

  14. Collective Biography and Memory Work: Girls Reading Fiction

    Science.gov (United States)

    Gannon, Susanne

    2015-01-01

    Collective biography draws on memory work methods developed initially by feminist sociologists (Haug et al., 1987) where people collaboratively examined the social and discursive resources through which they take themselves up as particular gendered subjects in the world. Their own memories become resources to investigate processes of…

  15. The Stegman Papers: biography of a leader in dermatologic surgery.

    Science.gov (United States)

    Redbord, Kelley P; Hanke, C William

    2012-06-01

    The Stegman Papers is a biography of Dr. Samuel J. Stegman. The papers were collected by Dr. Stegman during his lifetime as a dermatologic surgeon and leader. The manuscript includes a time line of Dr. Stegman's life and listing of his accomplishments, including significant publications.

  16. Major Greenwood (1880-1949): the biography.

    Science.gov (United States)

    Farewell, Vern; Johnson, Tony

    2016-12-30

    Background is provided on the discovery of an unpublished biography of Major Greenwood written by one of his sons. The motivation and preparation for online publication of the biography in Statistics in Medicine are outlined. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  17. A Biography of Henri Poincar\\'e - 2012 Centenary of the Death of Poincar\\'e

    CERN Document Server

    Weinstein, Galina

    2012-01-01

    On January 4, 2012, the centenary of Henri Poincar\\'e's death, a colloquium was held in Nancy, France the subject of which was "Vers une biographie d'Henri Poincar\\'e". Scholars discussed several approaches for writing a biography of Poincar\\'e. In this paper I present a personal and scientific biographical sketch of Poincar\\'e, which does not in any way reflect Poincar\\'e's rich personality and immense activity in science: When Poincar\\'e traveled to parts of Europe, Africa and America, his companions noticed that he knew well everything from statistics to history and curious customs and habits of peoples. He was almost teaching everything in science. He was so encyclopedic that he dealt with the outstanding questions in the different branches of physics and mathematics; he had altered whole fields of science such as non-Euclidean geometry, Arithmetic, celestial mechanics, thermodynamics and kinetic theory, optics, electrodynamics, Maxwell's theory, and other topics from the forefront of Fin de Si\\`ecle phys...

  18. Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy

    DEFF Research Database (Denmark)

    Salale, Nesrin; Treldal, Charlotte; Mogensen, Stine;

    2014-01-01

    Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult...... with a lidocaine spray proved to be a superior option as topical pharyngeal anesthetic before an UGE....

  19. Topics in effective field theory as applied to lattice QCD

    Science.gov (United States)

    Smigielski, Brian

    This thesis focuses on understanding aspects of hadronic physics using numerical and analytic computations which comprise the research fields of Lattice QCD and Effective Field Theories. Lattice QCD is a numerical approximation to QCD that is computed within a finite spacetime volume, a finite lattice spacing, and unphysically large values of the quark mass used to limit computational run time. Because Lattice QCD calculations are implemented with these constraints, it becomes necessary to understand how these constraints influence the physics if we are to extract physical observables. This requires the use and matching of an effective field theory for mesons and baryons which are the fundamental degrees of freedom of the effective field theory Lagrangian. We consider pion and nucleon interactions in Chapter 3 when computational demands force the use of small, spacetime lattices, and extract the axial charge of the nucleon. In Chapters 4 and 5 we examine systems of up to twelve particles of single species, pions or kaons, and mixed species systems of pions and kaons. From these systems we learn about the scattering lengths and three-body forces of these particles. These multi-particle systems also allow one to understand the behavior of finite density systems on the lattice. Lastly in Chapter 6, we examine parton distributions of the pion for a nonzero change in the pion's momentum. These are known as generalized parton distributions and reveal information regarding the valence quarks within a particular hadron. Before the advent of QCD, however, these particles were also known as partons.

  20. Solid effervescent formulations as new approach for topical minoxidil delivery.

    Science.gov (United States)

    Pereira, Maíra N; Schulte, Heidi L; Duarte, Natane; Lima, Eliana M; Sá-Barreto, Livia L; Gratieri, Tais; Gelfuso, Guilherme M; Cunha-Filho, Marcilio S S

    2017-01-01

    Currently marketed minoxidil formulations present inconveniences that range from a grease hard aspect they leave on the hair to more serious adverse reactions as scalp dryness and irritation. In this paper we propose a novel approach for minoxidil sulphate (MXS) delivery based on a solid effervescent formulation. The aim was to investigate whether the particle mechanical movement triggered by effervescence would lead to higher follicle accumulation. Preformulation studies using thermal, spectroscopic and morphological analysis demonstrated the compatibility between effervescent salts and the drug. The effervescent formulation demonstrated a 2.7-fold increase on MXS accumulation into hair follicles casts compared to the MXS solution (22.0±9.7μg/cm(2) versus 8.3±4.0μg/cm(2)) and a significant drug increase (around 4-fold) in remaining skin (97.1±29.2μg/cm(2)) compared to the drug solution (23.5±6.1μg/cm(2)). The effervescent formulations demonstrated a prominent increase of drug permeation highly dependent on the effervescent mixture concentration in the formulation, confirming the hypothesis of effervescent reaction favoring drug penetration. Clinically, therapy effectiveness could be improved, increasing the administration interval, hence, patient compliance. More studies to investigate the follicular targeting potential and safety of new formulations are needed.

  1. WILLIAM GURNEE SINNIGEN - 20TH CENTURY CLASSICIST AND ROMAN HISTORIAN: BIOGRAPHY & BIBLIOGRAPHY

    Directory of Open Access Journals (Sweden)

    Matthew Gray Marsh

    2016-04-01

    Full Text Available William Gurnee Sinnigen was a Classicist and Roman historian, active in the mid-to-late 20th century. Trained at the University of Michigan by noted Roman administrative historian Arthur E. R. Boak, Sinnigen continued his mentor’s work in administrative history, producing several articles on different aspects of Roman and Byzantine administrative topics.  Sinnigen was also responsible for the revision and update of Boak’s acclaimed textbook on Roman history, as well as Charles Alexander Robinson’s textbook on Ancient history.  This article will provide a brief biography of Professor Sinnigen, along with a bibliography of his published works and reviews by other scholars of his work.

  2. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2011-04-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  3. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2012-02-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  4. Oral History in Biography: A Shaping Source.

    Science.gov (United States)

    Weidman, Bette S.

    1987-01-01

    Examines the relationship between oral history and biography. Looks specifically at three studies of individual American Indians. Investigates the literary forms authors invented, reshaped, or adopted to bring oral narrative into biographic form. (RKM)

  5. Biographies of Albert Einstein -- Mastermind of Theoretical Physics

    CERN Document Server

    Weinstein, Galina

    2012-01-01

    Over the years many have written biographies of Einstein. They all based their biographies on primary sources, archival material: memories and letters of people who were in contact with Einstein, Einstein's own recollections; interviews that Einstein had given over the years, and letters of Einstein to his friends - youth friends like Marcel Grossman and Michele Besso and later friends and colleagues like Heinrich Zangger; and especially his love letters with Mileva Mari\\'c. One can demarcate between two types of biographies, namely, Documentary biographies, and, Non-documentary biographies. Non-documentary biographies were written by people who based themselves on documentary biographies and on other non-documentary biographies. Documentary biographies were written by people who knew Einstein personally, and received information from him and from other people who were in personal contact with him. This type can be further divided into two subgroups: books that were written while Einstein was still alive, and...

  6. Becoming Men, Becoming-Men?: A Collective Biography

    OpenAIRE

    2008-01-01

    Abstract In their collaborations over recent years the authors have worked, through their written dialogue, in pursuit of understanding subjectivities and their 'becomings'. Until now they have not explicitly explored their subjectivities as men. Their starting point in this paper is that they do not take the assignation 'men' for granted. Using collective biography, they are interested in how the worlds that they inhabited and that inhabited them in their early lives produced, and continue t...

  7. Topical cyclosporin as an alternative treatment for vision threatening blepharokeratoconjunctivitis: a case report

    Directory of Open Access Journals (Sweden)

    Ismail AS

    2012-06-01

    Full Text Available Abdul-Salim Ismail,1,2 Rohana Taharin,2 Zunaina Embong11Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 2Department of Ophthalmology, Hospital Pulau Pinang, Jalan Resindensi, Pulau Pinang, MalaysiaAbstract: Here, a case of vision threatening blepharokeratoconjunctivitis that responded well to topical cyclosporin is reported. A 9-year-old Malay girl with a history of bilateral blepharokeratoconjunctivitis was regularly treated with lid scrubbing using diluted baby shampoo, fusidic acid gel, and topical steroids as well as an intermittent course of oral doxycycline for the past year. She developed acute onset bilateral eye redness associated with poor vision in her right eye. Both eyes showed marked diffuse hyperemic conjunctiva with corneal vascularization. The presence of corneal vascularization obscured the visual axis in the right eye. The condition did not improve with regular intensive lid hygiene using diluted baby shampoo, fusidic acid gel, and topical steroids. She was started on topical cyclosporin A 0.5% every 6 hours. There was a dramatic regression of corneal vascularization after 3 days on topical cyclosporin, with marked improvement in visual acuity. This is a single case in which cyclosporin improved the status of the ocular surface. A large cohort study is required to justify its effectiveness in treating blepharokeratoconjunctivitis and to test its potential as an alternative immunosuppressive agent in comparison to conventional corticosteroids.Keywords: blepharokeratoconjunctivitis, cyclosporin

  8. Telling Our Stories, Sharing Our Lives: Collective Biographies of Women.

    Science.gov (United States)

    Bucher, Katherine T.; Manning, M. Lee

    1998-01-01

    Discusses how to evaluate collective biographies of women, offering specific evaluation and selection criteria that examine the author, the collection itself, bias and stereotypes, the relationship of the collective biography's text to other books, and the intended audience. Discusses 29 books that offer collective biographies of women. (SR)

  9. Second Birth--Biography: Kalashnikov, M. T.

    Science.gov (United States)

    1974-06-14

    ADAO 1 SECOND BIRTH-.- BIOGRAPHY : KALASHNIKOV, M. T. V V Zhukov Army Foreign Science and Technology Center Charlottesville, Virginia DISTRIBUTED BY...I.ajc 6/14/74 0 1 I 1 i1I I IP, 1, Se,,or d birtl!- Biography : Kalashnikov, H~. T. ’d ’I R* oscow, Voycnizdat. 󈨃, 136 pp. Vtoroye,Posndeniye \\N(I xI...Zoya says: symphony and classical without fail. Handel, Bach, Mozart . She even says that when she seeit the admiralty she can hear the sounds of an

  10. Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery.

    Science.gov (United States)

    Fang, Jia-You; Leu, Yann-Lii; Chang, Chia-Chun; Lin, Chia-Hsuan; Tsai, Yi-Hung

    2004-01-01

    The application of lipid nano/submicron emulsions as topical drug carrier systems for the percutaneous absorption of flurbiprofen was investigated. The lipid emulsions were made up of isopropyl myristate (IPM), soybean oil, or coconut oil as the oil phase, egg lecithin as the predominant emulsifier, and double-distilled water as the external phase. Stearylamine (SA) and deoxycholic acid (DA) also were used to produce positively and negatively charged emulsions. To evaluate the physicochemical properties of the lipid emulsions, particle size by laser light scattering, the image of atomic force microscopy, and relaxation time values by Nuclear Magnetic Resonance (NMR) were determined. The in vitro permeation data showed that incorporation of SA significantly reduced the topical delivery of flurbiprofen. On the other hand, incorporation of DA exhibited no or a negligible effect on drug permeation. Enhancement of drug absorption was observed when adding oleic acid as part of the oil phase. The in vivo topical application of flurbiprofen from selected lipid emulsions showed a similar trend to the in vitro status. Furthermore, the intersubject variability was considerably reduced by lipid emulsions than by aqueous suspensions in both the in vitro and in vivo experiments. The irritant profiles of lipid emulsions showed that IPM elicited higher irritation than soybean oil. The incorporation of oleic acid also produced skin disruption. The results in the present study suggest the feasibility of lipid emulsions for the topical delivery of flurbiprofen.

  11. Collective Biography and the New Political History.

    Science.gov (United States)

    Vandermeer, Philip

    1980-01-01

    Suggests that studying collective biographies for political history provides a means of analyzing the behavior, experience and character of many different groups. The approach improves the historian's sensitivity to the majority of historical actors and significantly expands understanding of individuals. (Author/KC)

  12. Small Worlds: Biography in the Interdisciplinary Survey

    Science.gov (United States)

    Waller, David

    2008-01-01

    The interdisciplinary survey inherits from more traditional survey courses the weaknesses embodied in the survey textbook. The standard textbook presentation gives students the impression that each figure's music, art, or literature is the product of the "spirit of the age." Well-chosen biographies temper that presentation by drawing attention to…

  13. Treatment of corneal squamous cell carcinoma using topical 1% 5-fluorouracil as monotherapy.

    Science.gov (United States)

    Dorbandt, Daniel M; Driskell, Elizabeth A; Hamor, Ralph E

    2016-05-01

    The purpose of this report is to discuss the use of topical 1% 5-fluorouracil as a sole therapy for canine corneal squamous cell carcinoma (SCC). A 12-year-old castrated male pug was evaluated for a well-demarcated, central, 3 mm in diameter, pale pink, raised, right corneal mass. An incisional biopsy was obtained using a #64 beaver blade after topical anesthesia and without sedation. A definitive diagnosis of corneal SCC was obtained after histopathologic evaluation of the biopsy. Topical 1% 5-fluorouracil ointment was applied to the right eye four times daily for 2 weeks followed by no treatment for 2 weeks, then treatment again twice daily for 2 weeks. The cornea remained free of recurrence 10 months after cessation of treatment. In dogs affected with corneal SCC, topical 1% 5-fluorouracil monotherapy may be a viable and cost-effective treatment option with minimal side effects. This chemotherapy agent may also have an effect on corneal pigmentation. Chronic cyclosporine therapy did not contribute to the pathogenesis of corneal SCC in the case described.

  14. 论方外传记中的类传%On Class Biography of Recluse Biography

    Institute of Scientific and Technical Information of China (English)

    俞樟华; 娄欣星

    2012-01-01

    方外传记中的类传,是专门记载性质相同、行为相近的僧侣、道士或世俗教徒事迹的一种传记形式,它产生于魏晋时期,以后代代相承,颇有发展。其中《高僧传》是中国佛教史上第一部系统的僧人类传,《大唐西域求法高僧传》则记载了中国僧人和朝鲜、越南僧人以及中亚细亚僧人总计56人西行求法的事迹,是一部具有国际意义的僧人类传。明清以来,民间佛教与居士佛教开始发展起来,因此,描写世俗教徒的类传也得到发展,清代彭际清所编的《居士传》,可谓居士类传的集成之作。僧人类传在形式上受到史传中的类传的影响,但是在记载内容、思想观念和叙事风格上都有明显的差异。%Class biography of recluse biography is a kind of biography typically recording the deeds of monks, priests, or secular followers which are in the same nature and with similar behavior; it originates in Wei and Jin dynasties, and it is developing from generation to generation. Eminent Monk Biography is the first systematic monk biography in the history of Chinese Buddhism. Tales of the Hierarchs Searching Buddhist Scripture in Western Regions of Tang Dynasty has recorded the westbound joumey of 56 monks, who are from China, North Korea, Vietnam, and Central Asia, which is of international importance. Ever since Ming and Qing dynasties, folk Buddhism and kulapati Buddhism have come in vogue, therefore, class biography describing the secular followers gets developing. Kulapati Biography by Peng Jiqing in Qing dynasty is a masterwork. Although the form of monks' class biography is affected by the class biography of historical biography, there are significant differences in their contents, ideas, and narrative styles.

  15. In vitro analysis of polyurethane foam as a topical hemostatic agent.

    Science.gov (United States)

    Broekema, Ferdinand I; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H; Bos, Rudolf R M

    2011-04-01

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has been evaluated and compared to commonly used agents. An experimental in vitro test model was used in which human blood flowed through the test material. Different modified polyurethane foams were compared to collagen and gelatin. The best coagulation was achieved with collagen. The results of the polyurethane foam improved significantly by increasing the amount of polyethylene glycol. Therefore, the increase of the PEG concentration seems a promising approach. Additional in vivo studies will have to be implemented to assess the application of polyurethane foam as a topical hemostatic agent.

  16. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib.

    Science.gov (United States)

    Bragagni, Marco; Mennini, Natascia; Maestrelli, Francesca; Cirri, Marzia; Mura, Paola

    2012-01-01

    Topical administration of celecoxib proved to be an effective mean of preventing skin cancer development and improving anticancer drugs effectiveness in skin tumors treatment. The aim of this study was the development of an effective topical formulation of celecoxib, able to promote drug skin delivery, providing its in depth penetration through the skin layers. Three kinds of vesicular formulations have been investigated as drug carriers: liposomes containing a surfactant, or transfersomes and ethosomes, containing suitable edge activators. Firstly, the effect of membrane composition variations on the system performance has been evaluated for each vesicle type. Selected formulations were characterized for particle size, polydispersity index and encapsulation efficiency. The best formulations were subjected to ex vivo permeation studies through excised human skin. All vesicular formulations markedly (p ethosomes, respectively. In particular, ethosomes containing Tween 20 as edge activator not only showed the best vesicle dimensions and homogeneity, and the highest encapsulation efficacy (54.4%), but also enabled the highest increase in drug penetration through the skin, probably due to the simultaneous presence in their composition of ethanol and Tween 20, both acting as permeation enhancers. Therefore, among the various vesicular formulations examined in the study, Tween 20-ethosomes can be considered the most promising one as carrier for topical celecoxib applications aimed to prevent skin cancer development and increase the anticancer drugs effectiveness against skin tumors.

  17. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Denes [Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  18. [Medical topics of the Goethe period as reflected in the Goethe Dictionary].

    Science.gov (United States)

    Schlaps, Christiane

    2010-01-01

    This paper deals with some medical topics which were mentioned or discussed by Johann Wolfgang von Goethe and can thus be found in the dictionary which lists and explains all the words he used, the Goethe Dictionary. The author makes a case for the use of this primarily literary and linguistic work e. g. as source material for historians of medicine and shows some of its possible uses.

  19. Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation.

    Science.gov (United States)

    El-Hadidy, Gladious Naguib; Ibrahim, Howida Kamal; Mohamed, Magdi Ibrahim; El-Milligi, Mohamed Farid

    2012-01-01

    This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers were incorporated, namely sodium deoxycholate or oleic acid. Drug-loaded MEs were evaluated for their physical appearance, pH, rheological properties and in vitro permeation studies using guinea pig skin. MEs based on polyoxyethylene(10)oleyl ether (Brij 97) as the surfactant showed pseudoplastic flow with thixotropic behavior and were loaded with voriconazole. Jojoba oil-based MEs successfully prolonged voriconazole release up to 4 h. No significant changes in physical or rheological properties were recorded on storage for 12 months at ambient conditions. The presence of permeation enhancers favored transdermal rather than dermal delivery. Sodium deoxycholate was more effective than oleic acid for enhancing the voriconazole permeation. Voriconazole-loaded MEs, with and without enhancers, showed significantly better antifungal activity against Candida albicans than voriconazole supersaturated solution. In conclusion, the studied ME formulae could be promising vehicles for topical delivery of voriconazole.

  20. Resina Draconis as a topical treatment for pressure ulcers: A systematic review and meta-analysis.

    Science.gov (United States)

    Xu, Jiaqi; Xiong, Tian; Yang, Ying; Li, Jie; Mao, Jing

    2015-01-01

    In recent years, a number of studies have reported on Resina Draconis (RD) as a topical treatment for pressure ulcers. To evaluate these studies, we performed a systematic review and meta-analysis aimed to examine the efficacy of RD for pressure ulcers. We searched eight electronic databases to identify randomized controlled trials in which RD treatment was compared with other topical treatment of pressure ulcers from 1980 to 2014. Selection of studies, study appraisal, data extraction and analysis were undertaken using standard methods. Fourteen randomized controlled trials were included involving 618 patients. The results of the meta-analysis showed that, RD treatment was significantly associated with a higher healing rate for pressure ulcers (risk ratio 2.07, 95% confidence intervals 1.73-2.48, p < 0.001). The results of descriptive analysis showed that, compared with the control group, RD treatment shortened healing time. As for safety, adverse reactions had not been reported. These results suggest that RD can improve the healing rate for pressure ulcers and shorten the healing time, compared with other topical treatments. However, due to limited quality and quantity of the included studies, this conclusion needs to be proved by more high quality studies.

  1. Book history as a research topic in Croatian journals from 2001 to 2010

    Directory of Open Access Journals (Sweden)

    Jasna Tingle

    2013-02-01

    Full Text Available The aim of the paper is to determine the scope and content of Croatian research output in the field of book history, determine which Croatian journals publish papers on book history, the topics covered and the number of scholars who do research in this field. The research was conducted on the corpus of 177 papers published in 17 Croatian journals from 2001 to 2010. The data collected indicates that few journals regularly publish papers on book history, and only one journal explicitly states book history as its major area of interest. Furthermore, it is evident that very few scholars regularly or occasionally do research on book history. The topics covered in selected papers bear witness to a wide range of interests, but only few papers follow recent trends in world book history research. This paper, however, does not cover scholarly or trade monographs and conference proceedings published during the time under investigation, which is one of the limitations of the current research. Still, the output in scholarly and trade journals, which are the main channels of scholarly communication, provides a relevant sample for determining the incidence of book history as a research topic in Croatian science. These findings are the main research contribution of this paper.

  2. Personality and Biography: Proceedings of the Sixth International Conference on the History of Adult Education. Volume II: Biographies of Adult Educators from Five Continents.

    Science.gov (United States)

    Friedenthal-Haase, Martha, Ed.

    This volume contains 36 biographies: "I.T.A. Wallace-Johnson and Radical Adult Education (AE) in Sierra Leone in the Years 1938/1939" (Turay); "Frank C. Laubach as the Father of the Adult Literacy Movement in India" (Ghosh); "A Historical Study on the Theory and Practice of Social and AE in Korea" (Lee); "Integrative Adult Educators" (Yaron);…

  3. American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography; J. Robert Oppenheimer. Die Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Kai; Sherwin, Martin J.

    2009-07-01

    A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [German] J. Robert Oppenheimer (1904-1967), der ''Vater der Atombombe'', zaehlt zu den schillerndsten Figuren der juengeren Zeitgeschichte. Fuer ihre glaenzende Biographie des ''amerikanischen Prometheus'' erhielten der Journalist Kai Bird und der Historiker Martin J. Sherwin den Pulitzer-Preis. Exemplarisch lassen sie das Drama eines Forschers lebendig werden, der sich zwischen Erkenntnisdrang und ethischer Verantwortung entscheiden muss. Oppenheimer leitete das streng geheime Manhattan-Projekt in der Wueste von New Mexico, wo am 16. Juli 1945 die erste Atombombe gezuendet wurde. Kurz darauf starben in Hiroshima und Nagasaki mehr als 200 000 Menschen durch die neue ''Wunderwaffe'' - die Menschheit war ins Atomzeitalter eingetreten. Erschuettert von der Zerstoerungskraft seiner Schoepfung, engagierte sich Oppenheimer fortan gegen den Einsatz nuklearer Waffen. Das machte ihn im Amerika der McCarthy-Aera verdaechtig. Er geriet ins Visier des FBI, wurde als Spion der Sowjetunion verleumdet und musste den Staatsdienst quittieren. Sein Privatleben wurde an die Oeffentlichkeit gezerrt, seine Wohnung verwanzt, sein Telefon abgehoert. Erst 1963 rehabilitierte ihn Praesident Kennedy. Ueber dreissig Jahre hinweg haben die Autoren Interviews mit Oppenheimers Angehoerigen, Freunden und Kollegen gefuehrt, FBI-Akten gesichtet, Tonbaender von Reden und Verhoeren

  4. Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic

    DEFF Research Database (Denmark)

    Brødsgaard, Anne; Nielsen, Tove; Mølgaard, Ulla

    2015-01-01

    AIM: There is a lack of evidence on the best treatment option for umbilical granuloma. The primary aim of this study was to compare three treatments for umbilical granuloma: standard treatment with topical silver nitrate, clobetasol propionate cream (0.05%) and ethanol wipes. The secondary aim......%) in the outpatient clinic, 30 infants had topical clobetasol propionate cream (0.05%) applied at home, and 34 infants received cleansing with ethanol wipes (82%) at home. RESULTS: Silver nitrate and clobetasol propionate cream (0.05%) were significantly superior to ethanol wipes, with shorter healing times...... and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting. CONCLUSION: Treating umbilical granuloma with topical clobetasol propionate...

  5. Marital Biography, Social Security Receipt, and Poverty.

    Science.gov (United States)

    Lin, I-Fen; Brown, Susan L; Hammersmith, Anna M

    2017-01-01

    Increasingly, older adults are unmarried, which could mean a larger share is at risk of economic disadvantage. Using data from the 2010 Health and Retirement Study, we chart the diverse range of marital biographies, capturing marital sequences and timing, of adults who are age eligible for Social Security and examine three indicators of economic well-being: Social Security receipt, Social Security benefit levels, and poverty status. Partnereds are disproportionately likely to receive Social Security and they enjoy relatively high Social Security benefits and very low poverty levels. Among singles, economic well-being varies by marital biography and gender. Gray divorced and never-married women face considerable economic insecurity. Their Social Security benefits are relatively low, and their poverty rates are quite high (over 25%), indicating Social Security alone is not sufficient to prevent these women from falling into poverty. By comparison, gray widoweds are the most advantaged singles.

  6. Biography,from History to Literature%传记:从历史到文学

    Institute of Scientific and Technical Information of China (English)

    孙德喜

    2011-01-01

    Biography belongs to history in the ancient time and most of their writers are history officials.And the biography writers are loyal to history and responsible for history.The aim of biography writing is that history is regarded as a mirror for rulers.In%传记在古代隶属于历史,作者以史官为主,重在忠于历史,对历史负责,意在以史为鉴。进入20世纪,传记随着社会变革发生了转型,向文学领域迈进。传记作者的文学意识开始自觉并且日渐突出,传记作品的文学性渐渐得到强化,传记的审美功能日益显著。

  7. Expanded abstracts with biographies - 1985 technical program

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    A total of 50 papers were presented at the conference in 13 sessions with the following headings: applied geophysical surveys; borehole geophysics; EM modeling; engineering geophysics; geological papers from AAPG, gravity and magnetics; mining geophysics; magnetotellurics; EPRI sessions; logging accuracy; ideals and limitations; seismic sessions; and special SEG workshops. Author's biographies have been included, and abstracts appear in the form submitted by their authors.

  8. An Introduction to Topic Modeling as an Unsupervised Machine Learning Way to Organize Text Information

    Science.gov (United States)

    Snyder, Robin M.

    2015-01-01

    The field of topic modeling has become increasingly important over the past few years. Topic modeling is an unsupervised machine learning way to organize text (or image or DNA, etc.) information such that related pieces of text can be identified. This paper/session will present/discuss the current state of topic modeling, why it is important, and…

  9. Anti-inflammatory effects of eugenol nanoemulsion as a topical delivery system.

    Science.gov (United States)

    Esmaeili, Fariba; Rajabnejhad, Saeid; Partoazar, Ali Reza; Mehr, Shahram Ejtemaei; Faridi-Majidi, Reza; Sahebgharani, Mousa; Syedmoradi, Leila; Rajabnejhad, Mohammad Reza; Amani, Amir

    2016-11-01

    Eugenol is the main constituent of clove oil with anti-inflammatory properties. In this work, for the first time, O/W nanoemulsion of eugenol was designed for the evaluation of anti-inflammatory effects as a topical delivery system. Topical formulations containing 1%, 2% and 4% of eugenol as well as a nanoemulsion system containing 4% eugenol and 0.5% piroxicam were prepared. Further to physicochemical examinations, such as determination of particle size, polydispersity index, zeta potential and physical stability, anti-inflammatory activity was examined in carrageenan-induced paw edema in rats. The optimum formulation was found to contain 2% eugenol (oil phase), 14% Tween 20 (surfactant) and 14% isopropyl alcohol (co-surfactant) in water. Nanoemulsion with polydispersity index of 0.3 and median droplet diameter of 24.4 nm (d50) was obtained. Animal studies revealed that the nanoemulsions exhibited significantly improved anti-inflammatory activity after 1.5 h, compared with marketed piroxicam gel. Additionally, it was shown that increasing the concentration of eugenol did not show higher inhibition of inflammation. Also, the nanoemulsion having piroxicam showed less anti-inflammatory properties compared with the nanoemulsion without piroxicam.

  10. Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice

    Science.gov (United States)

    Parihar, Suraj P.; Hartley, Mary-Anne; Hurdayal, Ramona; Guler, Reto; Brombacher, Frank

    2016-01-01

    We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the immunomodulatory potential of simvastatin as a topical or systemic host-directed drug therapy in controlling inflammatory responses in an experimental mouse model of cutaneous leishmaniasis caused by Leishmania major (LV39). In an ear infection model, topical application of simvastatin directly on established lesions significantly reduced severity of the disease reflected by ear lesion size and ulceration. The host protective effect was further accompanied by decreased parasite burden in the ear and draining lymph nodes in both BALB/c and C57BL/6 mice. Pre-treatment of these mice on a low-fat cholesterol diet and systemic simvastatin also reduced footpad swelling, as well as parasite burdens and ulceration/necrosis in the more robust footpad infection model, demonstrating the prophylactic potential of simvastatin for cutaneous leishmaniasis. Mechanistically, following L. major infection, simvastatin-treated primary macrophages responded with significantly reduced cholesterol levels and increased production of hydrogen peroxide. Furthermore, simvastatin-treated macrophages displayed enhanced phagosome maturation, as revealed by increased LAMP-3 expression in fluorescent microscopy and Western blot analysis. These findings demonstrate that simvastatin treatment enhances host protection against L. major by increasing macrophage phagosome maturation and killing effector functions. PMID:27632901

  11. Learning about Teaching the Extracurricular Topic of Nanotechnology as a Vehicle for Achieving a Sustainable Change in Science Education

    Science.gov (United States)

    Blonder, Ron; Mamlok-Naaman, Rachel

    2016-01-01

    This study focused on teachers' transfer of a variety of teaching methods from a teaching module on nanotechnology, which is an example of a topic outside the science curriculum, to teaching topics that are part of the chemistry curriculum. Nanotechnology is outside the science curriculum, but it was used in this study as a means to carry out a…

  12. Supreme Court Biographies as a Classroom Resource

    Science.gov (United States)

    Ryan, John Paul

    2009-01-01

    In this article, the author goes beyond Supreme Court decisions to investigate the upbringing and personalities of three Supreme Court justices who left their mark on history: Oliver Wendell Holmes, Jr., Thurgood Marshall, and Sandra Day O'Connor. His interviews with their biographers, G. Edward White for Oliver Wendell Holmes Jr., Juan Williams…

  13. Musicians as lifelong learners: discovery through biography

    NARCIS (Netherlands)

    Smilde, Rineke

    2009-01-01

    Today musicians face major changes in their professional life, confronted with questions of how to function flexibly and exploit opportunities in the rapidly changing cultural context. To this end, the concept of lifelong learning is being investigated within this study. Biographical research into

  14. Evaluation of Topical Preparations Containing Curcuma, Acacia and Lupinus Extracts as an Anti-inflammatory Drugs

    Directory of Open Access Journals (Sweden)

    M M Hamzah

    2011-06-01

    Full Text Available Summary: This work was suggested on the basis of presence of curcuminoids in curcuma and the presence of flavonoidal constituent in acacia and lupinus. The aim of this study was to study their possible anti-inflammatory effect by separately formulation of the three extracts in a suitable gel formula for topical administration and comparison of the prepared gels with a standard gel in the market (diclosal Emulgel by using the carrageenan induced paw edema model in albino rats. The extracts were subjected to phytochemical screening tests using reported methods to determine the presence of various phytoconstituents. Gel formulation was prepared containing 8% of each extract separately in gel base, namely sodium carboxy methyl cellulose (NaCMC. The pharmacological screening revealed that percent reduction of edema produced by curcuma extract was 30.0%, by acacia extract was 4%, by ethanol fraction lupinus was 18% and by chloroform fraction lupinus was 11.3%, while diclofenac sodium topical gel produced 48% reduction of edema. Industrial relevance: Medicinal plants provide a host of chemical compounds, which have been optimized on the basis of their biological activities. Chemical compounds present in medicinal plants have shown great promise in the management of various inflammatory disorders and have continued to serve as alternative and complementary therapies. The present study will help the industry to produce herbal drug effective in the treatment of inflammation with less side effect and less costly when compared to the synthetic drugs.

  15. The Gendering of Albert Einstein and Marie Curie in Children's Biographies: Some Tensions

    Science.gov (United States)

    Wilson, Rachel E.; Jarrard, Amber R.; Tippins, Deborah J.

    2009-01-01

    Few twentieth century scientists have generated as much interest as Albert Einstein and Marie Currie. Their lives are centrally depicted in numerous children's biographies of famous scientists. Yet their stories reflect interesting paradoxes and tacit sets of unexplored sociocultural assumptions about gender in science education and the larger…

  16. A Collective Biography of the Founders of the American Association of University Women

    Science.gov (United States)

    Morgan, Alberta J.

    2013-01-01

    This archival study used constructivist grounded theory to document the educational and professional lives of seventeen women who founded the Association of Collegiate Alumnae (ACA) in 1881, which later became known as the American Association of University Women (AAUW). This study resulted in a collective biography of the seventeen women which…

  17. Musicians’ profession-related health issues and their evolving transformative learning through biography

    NARCIS (Netherlands)

    Smilde, Rineke

    2009-01-01

    Within a study on ‘musicians as lifelong learners’, explorative biographical research was used. When analysing the learning biographies informed by grounded theory, the emergence of profession-related health issues was striking. More than half of the portrayed musicians suffered from both physical a

  18. Assessment of topical versus oral ivermectin as a treatment for head lice.

    Science.gov (United States)

    Ahmad, Hesham M; Abdel-Azim, Eman S; Abdel-Aziz, Rasha T

    2014-01-01

    Many medications are available for treatment of pediculosis capitis including ivermectin. Our aim is to compare the efficacy and safety of topical versus oral ivermectin in treatment of pediculosis capitis. Sixty-two patients with proved head lice infestation were included and divided into group I (31 patients; received single topical application of 1% ivermectin) and group II (31 patients; received single dose of oral ivermectin). Treatment was repeated after 1 week for nonresponders. At 1 week after treatment, the eradication rates and improvement of pruritus were significantly higher among patients who received topical than oral ivermectin. When a second treatment, topical or oral, was given to nonresponders, the cure rates of infestation and pruritus was 100% and 97% among patients treated with topical and oral ivermectin, respectively with no significant difference between the two groups. This study suggests that both topical and oral ivermectin demonstrate high efficacy and tolerability in treatment of pediculosis capitis. However, a single treatment with topical ivermectin provides significantly higher cure of infestation and faster relief of pruritus than oral ivermectin. In addition, whether topical or oral ivermectin is used to treat head lice, a second dose is required in some cases to ensure complete eradication.

  19. Creating Biography Webs to Investigate Individuals' Historical Contexts

    Science.gov (United States)

    Fertig, Gary; Silverman, Rick

    2009-01-01

    Biographies, which are popular among young people, can stimulate interest in the past when students investigate the historical contexts in which individuals lived. Creating biography webs offers students structured opportunities to investigate how other people and groups influenced the personal development of specific individuals (NCSS Strands II,…

  20. Keeleliste elulugude uurimisvõimalusi: Dagmar Normeti mitmekeelne lapsepõlv Eestis. Possibilities of Research on Linguistic Biographies: Dagmar Normet, a Multilingual Childhood in Estonia

    Directory of Open Access Journals (Sweden)

    Anna Verschik

    2012-04-01

    author’s personal shift from German to Estonian as a preferred language of communication. Jewish topics, although present in the narrative, are by no means dominant (i.e., the struggle between Yiddish and Hebrew, Jewish secularism and tradition, Jewish and non-Jewish world. The memoir differs radically from East-European Jewish memoirs (for instance, the series by Isaac Bashevis Singer in the sense that the outside world is not perceived as antagonistic and hostile to Jews in general and to the author in particular, and there is no identity conflict. As the narrative contains text in other languages (for instance, the author’s childhood poetry in German, and some extracts from her diary are provided with the explanation that the diary was initially in German, a problem of the original, translation and self-translation arises. A written memoir inevitably has to keep a potential reader in mind and long prose excerpts in German would be confusing to a modern Estonian reader. Yet in some places the author employs stylisation by introducing dates of diary entries in German, accompanied by the German name of Tallinn (Reval. We can never know for sure at which point the author switched to Estonian and whether this transition was abrupt or smooth. Thus, connections between the original language, the narrator’s goals, and self-translation poses a problem for interpretation because one cannot be sure in what language what events took place. Self-translation becomes especially significant in written linguistic biographies because written texts are more premeditated than oral ones.

  1. Gaining trust as well as respect in communicating to motivated audiences about science topics.

    Science.gov (United States)

    Fiske, Susan T; Dupree, Cydney

    2014-09-16

    Expertise is a prerequisite for communicator credibility, entailing the knowledge and ability to be accurate. Trust also is essential to communicator credibility. Audiences view trustworthiness as the motivation to be truthful. Identifying whom to trust follows systematic principles. People decide quickly another's apparent intent: Who is friend or foe, on their side or not, or a cooperator or competitor. Those seemingly on their side are deemed warm (friendly, trustworthy). People then decide whether the other is competent to enact those intents. Perception of scientists, like other social perceptions, involves inferring both their apparent intent (warmth) and capability (competence). To illustrate, we polled adults online about typical American jobs, rated as American society views them, on warmth and competence dimensions, as well as relevant emotions. Ambivalently perceived high-competence but low-warmth, "envied" professions included lawyers, chief executive officers, engineers, accountants, scientists, and researchers. Being seen as competent but cold might not seem problematic until one recalls that communicator credibility requires not just status and expertise but also trustworthiness (warmth). Other research indicates the risk from being enviable. Turning to a case study of scientific communication, another online sample of adults described public attitudes toward climate scientists specifically. Although distrust is low, the apparent motive to gain research money is distrusted. The literature on climate science communicators agrees that the public trusts impartiality, not persuasive agendas. Overall, communicator credibility needs to address both expertise and trustworthiness. Scientists have earned audiences' respect, but not necessarily their trust. Discussing, teaching, and sharing information can earn trust to show scientists' trustworthy intentions.

  2. Biography in (Education Historiography. A Brief Sketch of a Complex Relationship

    Directory of Open Access Journals (Sweden)

    Giuseppe Zago

    2015-12-01

    Full Text Available The aim of this paper is to reconstruct the role and development of biography in the Italian history of pedagogy after Italian unification, when education historiography began to gain its own autonomy. The first step is to identify the main features of educators biographies; the second step is to describe their evolution in the last forty years. In order to gain a deeper knowledge of this evolution, a large part of this study is devoted to describe the relationship between biography and historiography and to analyze the different attitudes towards the «individual» and individual actions as much as the standard models of biography in the course of time. How to reference this article Zago, G. (2016. La biografia nella storiografia e nella storiografia dell’educazione. Linee evolutive di un rapporto complesso. Espacio, Tiempo y Educación, 3(1, 203-234. doi: http://dx.doi.org/10.14516/ete.2016.003.001.11

  3. Biography and Action: A Schutzian Perspective to Life-world

    Directory of Open Access Journals (Sweden)

    Hermílio Santos

    2016-01-01

    Full Text Available Starting with the discussion on free-will and action, this paper discusses how Alfred Schutz approaches these issues for the comprehension of life-world. After a brief overview on how contemporary philosophers as Ernst Tugendhat and Ulrich Pothast face these problem, it is argued that for Schutz action plays a central role in his conception of life-world. The article goes further and advocates for the importance of exploring individual biographies as a way to provide an accurate understanding of actions. By the end of this text, it is suggested that the biographical narrative approach, as proposed by Fritz Schütze, as well as by Gabriele Rosenthal, is an important contribution to the Schutz’ perspective of the life-world and to adequately explore the most different social phenomena.

  4. 西方传记文史冲突与融合的突出表现--对传记的真实性、艺术性、功能性的考察%The Conflict and Mergence of Literature and History in Biography---Authenticity, Artistic, Functional

    Institute of Scientific and Technical Information of China (English)

    于振涛; 王艳颖

    2015-01-01

    Western History Biography category dispute exists long, and impact on their writing biographies. Along with biographies of modern transformation, biography differences become more prominent in cultural and historical characteristics. But the cultural and historical characteristics of the biography observation and research can be used as an important perspective. It is important that through all stages of the process finishing and grasp biography , especially for written in-depth analysis , technical investigation and the creation of goals writing principles of modern biography and classical biographies, that biography and literary creation by historians the double impact, further found biography in authenticity, artistic, functional highlights three distinct biography Writing History conflict and blending.%文章通过在对传记发展历程各个阶段中重要传记作品的整理与把握,尤其是对古典传记、近代传记的写作原则、记述手法以及创造目标的深入分析与考察,发现传记创作中深受文学与史学的双重影响,并且传记在真实性、艺术性、功能性三方面体现了传记写作的文史冲突与交融。

  5. Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Casadei

    2009-07-01

    Full Text Available A carboxymethyl derivative of scleroglucan (Scl-CM with a 65±5% carboxylic group degree of derivatization (DD was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Physical hydrogels with different Scl-CM/Ca+2 ratios were prepared and characterized for their rheological behaviour. Their potential as drug delivery systems was also evaluated. To this end three non steroidal anti-inflammatory drugs (NSAIDs were loaded into the hydrogels obtained with 2% w/v solution of Scl-CM and 0.05 and 0.1 M CaCl2. The release rate of the drugs was critically related to the salt concentration. By an appropriate combination of the hydrogels prepared using different amounts of salt, it was possible to obtain a system able to release diclofenac with zero-order kinetics. Primary skin irritation tests showed a good biocompatibility of the new polymer, as well as of its hydrogels. These results suggest a potential of the new hydrogels for the development of modified delivery systems in topical formulations.

  6. Topical issues of functioning a region as a social-economic system

    Directory of Open Access Journals (Sweden)

    Roman Andreyevich Timofeyev

    2015-09-01

    Full Text Available Objective to identify the topical issues of forming a region as a socialeconomic system. Methods systematic approach based on general scientific methods of empirical and theoretical research such as observation and comparison analysis and synthesis induction and deduction as well as comparativehistorical method statistical methods macroeconomic analysis. Results the major issues of applying a systematic approach to the analysis of the region as a socioeconomic system were explored and analyzed. The authors proved the most important features of the system considered different points of view on the content of the region as a system category analyzed the basic paradigm of the region functioning identified specific properties inherent to the region as a system conducted analysis of the modern Russian and foreign literature which showed that at present there is no consensus about the structural content of the region as an economic system at mesolevel suggested the authorsrsquo definition of the region category conclusions were made about the applicability of systematic approach to analyzing a region as a socioeconomic system. Scientific novelty the trends and problems of the region formation as an economic system were specifiedin the form of components of a single social and economic system the conceptual scheme for the region development as a socioeconomic system at mesolevel was proposed the author39s definition of the regionwas given. The suggested conceptual framework focuses on regional subsystems each of which is characterized by resources capacity the effective use of which is intended to ensure the sustainable and competitive territory development while increasing the quality of life of the population under federalism and globalization. Practical significance conclusions and suggestions can be used by public authorities in the strategic policy development for the effective management of the Russian regions. nbsp

  7. Mesoporous silica as a carrier for topical application: the Trolox case study.

    Science.gov (United States)

    Gastaldi, L; Ugazio, E; Sapino, S; Iliade, P; Miletto, I; Berlier, G

    2012-08-28

    As part of a recent research effort aimed at employing mesoporous materials for controlled drug delivery, this paper presents MCM-41 as a carrier for topical application, using Trolox as a model unstable guest molecule. The complexes between Trolox and MCM-41 were prepared by employing different inclusion procedures, varying solvent, method and pretreatment of the silica matrix. The objectives of this study were to determine Trolox loading, analyze its integrity and availability after immobilization on mesoporous silica, evaluate MCM-41 influence on Trolox photodegradation and establish whether the preparation method significantly influences complex properties. The characterization analyses (XRD, TGA, DSC and FTIR) confirmed the hydrogen-bonding interaction and Trolox structure preservation. Gas-volumetric analysis showed a consistent decrease in surface area and in pore volume and diameter with respect to bare MCM-41 indicating that Trolox was mainly located within mesopores. In vitro diffusion tests showed a slower release of Trolox after inclusion in the MCM-41 matrix; at the same time UV irradiation studies highlighted an increased photostability for the complex particularly in O/W emulsion. Moreover the radical scavenging activity of Trolox was maintained after immobilization. In all cases, differences were observed in all tested samples, suggesting that results could be optimized by modifying the inclusion procedure and by improving the guest loading.

  8. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  9. Working Capital Management as a routine: An action based access to the topic

    Directory of Open Access Journals (Sweden)

    Petra Kroflin

    2015-10-01

    Full Text Available In times of unstable capital markets on the one side and historically low interests on the other, working capital management must be discussed from different perspectives. Limited sources of liquidity, and the high refinancing risk of lending companies, make the reduction of current assets and liabilities an even more important management task than before. On the other hand, low interest rates raise the need for defining the optimum level for working capital. Little research and empirical evidence exists when it comes to lifting working capital targets to create value. The objective of the present paper is to give evidence on whether German companies adapt their behavior in terms of handling working capital in the actual economic environment and to describe which practices have been established to perform this adaptation. The given analysis is based on a qualitative study. The data used have been gathered in 2014 and 2015 during semi structured interviews with CFOs or financial executives of 15 German and Austrian industrial firms. Our study suggests that adaptation is realized rather by moderating management attention and focus to the topic of capital cost but not by adjusting the financial targets themselves. This is because working capital reduction as become a management routine.

  10. J.B. McLachlan: a biography

    Energy Technology Data Exchange (ETDEWEB)

    Frank, D.

    1999-07-01

    This social history and biography of James Bryson McLaughlin (1869-1916) describes McLaughlin's leadership as an educator and instigator in organizing Nova Scotia's coal miners during the labour wars in the 1920s. McLaughlin's background and childhood, education, reputation, religion, family life, health, and death are described. Included are descriptions of the life of coal miners in Cape Breton, radical left politics in Canada and the organizers involved, the political economy of the coal industry, child labour, churches, coal markets and prices, company towns and housing, mining disasters and fatalities, elections, First World War efforts, the depression, immigrants, and strikes. The labour organizations, companies, churches, and politicians involved in the struggles for union acceptance are discussed. 872 refs., 7 figs., 24 photos.

  11. Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas

    Institute of Scientific and Technical Information of China (English)

    Markus Schneider; Andreas Reimer; Hansjoerg Cremer; Peter Ruef

    2014-01-01

    Background: Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas. Methods: In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a "hemangioma score" to determine the treatment success. Results: In 147 of the 148 patients, strong signs of resolution under treatment included lightening, paling, and less vascularization. The hemangioma score showed a signifi cant decrease during the treatment. Relevant serum levels of propranolol were not found. Adverse effects were rare and not related to propranolol. Conclusion: Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.

  12. Efficacy of 2% Lidocaine Injection as a Topical Agent in Cataract Surgery

    Institute of Scientific and Technical Information of China (English)

    Wenyong Huang; Bin Liu; Jiewei Liu; Jinxing Xu; Zhende Lin

    2003-01-01

    Purpose: To determine whether 2% Lidocaine injection is an effective topical anesthetic agent for non-phaco small incision cataract surgery.Setting: Charity eye clinic supported by Hellen Keller International.Methods:One hundred and twenty-five consecutive cataract surgery patients received topical anesthesia with 2% Lidocaine injection solution just 1 and 0.5 minutes prior to non-phaco small incision cataract extraction and intraocular lens implantation. Each patient was asked about pain or piessure sensation during the operation.Results: The surgeon felt ease in the operations. Many patients (93/125) were comfort during the whole surgery. Only 9 patients′ score was above level 3,mostly complained during the nucleus extraction; Among those whose score was level 1~2, 82.6%(19/23)claimed discomfort at middle of the operation (nucleus extraction) or the beginning (creating the conjunctival flap).Conclusion: Lidocaine injection solution(2%) was an effective topical anesthesia agent in cataract surgery.

  13. Philippe Desan, Montaigne. Une biographie politique

    OpenAIRE

    Cavallini, Concetta

    2016-01-01

    Cet imposant volume, Montaigne. Une biographie politique, présente les hypothèses et le résultat des dernières recherches (souvent encore en cours) de Philippe Desan sur l’auteur des Essais. La définition de ‘politique’ permet de placer Montaigne et sa vie dans un contexte social, dans un réseau de connaissances, d’ambitions personnelles, d’ambitions de groupe social: dans l’univers de Montaigne, Philippe Desan inclut l’ensemble hétérogène de la société de la Renaissance, «ordres, clans, fami...

  14. Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry.

    Science.gov (United States)

    Ribeiro, Lígia N M; Franz-Montan, Michelle; Breitkreitz, Márcia C; Alcântara, Ana C S; Castro, Simone R; Guilherme, Viviane A; Barbosa, Raquel M; de Paula, Eneida

    2016-10-10

    In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the reason that patients abandon treatment. Topical anesthetics are applied in order to minimize the discomfort caused by needle insertion and injection, and to reduce the symptoms of superficial trauma at the oral mucosa, but there are still no efficient commercially available formulations. Factorial design is a multivariate data analysis procedure that can be used to optimize the manufacturing processes of lipid nanocarriers, providing valuable information and minimizing development time. This work describes the use of factorial design to optimize a process for the preparation of nanostructured lipid carriers (NLC) based on cetyl palmitate and capric/caprylic triglycerides as structural lipids and Pluronic 68 as the colloidal stabilizer, for delivery of the local anesthetics lidocaine and prilocaine (both at 2.5%). The factors selected were the excipient concentrations, and three different responses were followed: particle size, polydispersity index and zeta potential. The encapsulation efficiency of the most effective formulations (NLC 2, 4, and 6) was evaluated by the ultrafiltration/centrifugation method. The formulations that showed the highest levels of encapsulation were tested using in vitro release kinetics experiments with Franz diffusion cells. The NLC6 formulation exhibited the best sustained release profile, with 59% LDC and 66% PLC released after 20h. This formulation was then characterized using different techniques (IR-ATR, DSC, DRX, TEM, and NTA) to obtain information about its molecular organization and its physicochemical stability, followed during 14months of storage at 25°C. This thorough pre-formulation study represents an important advance towards the development of an efficient pre-anesthetic for use in dentistry.

  15. Exploring the biographies of prospective science teachers: Evolving perspectives on diversity and equity

    Science.gov (United States)

    George, Magnia Ayodele

    Science as a body of knowledge holds a highly regarded place in society. In recent years, science education has been the object of national scrutiny as the result of assessment data that indicates that the scientific literacy of students in the United States is marginal as compared to other advanced nations around the world. Students of color have been especially targeted due to the historical underrepresentation of this group in the sciences. Specifically access to a rigorous science curriculum and qualified teachers has been implicated in improving the chances of traditionally underserved students to participate and achieve in science. The aim of this study was to explore the perspectives (i.e., the beliefs, knowledge, and experiences) of prospective secondary science teachers regarding a science for all reform agenda. Constructivist, critical, and feminist methodologies were used to elicit prospective teachers' views of equity in science teaching and learning as they described their experiences as science learners and prospective science teachers. The topic of multicultural science education served as a context for focus group conversations. Analysis of conversations revealed that participants' lived experiences as learners and teachers-in-the-making shape their views of science and science education, their views of issues of diversity in teaching and learning, and their views of the organizational features of schooling. A dialogic relational perspective (DRP) model that attends to biography is proposed as a means for considering the roles of teacher, student, and science in relationship to the goals of science for all. The model is presented and discussed in the context of equity pedagogy for science teacher preparation and development.

  16. Bimatoprost Topical

    Science.gov (United States)

    Topical bimatoprost is used to treat hypotrichosis (less than the normal amount of hair) of the eyelashes by promoting ... growth of longer, thicker, and darker lashes. Topical bimatoprost is in a class of medications called prostaglandin ...

  17. Topical Pimecrolimus as a New Optional Treatment in Cutaneous Sarcoidosis of Lichenoid Type

    Directory of Open Access Journals (Sweden)

    Antonella Tammaro

    2014-01-01

    Full Text Available We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens.

  18. In vitro analysis of polyurethane foam as a topical hemostatic agent

    NARCIS (Netherlands)

    Broekema, Ferdinand I.; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H.; Bos, Rudolf R. M.

    2011-01-01

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study

  19. Experiences of Teaching the Heat Energy Topic in English as a Second Language

    Science.gov (United States)

    Halim, Lilia; Dahlan, Fathiyah; Treagust, David F.; Chandrasegaran, A. L.

    2012-01-01

    In view of the current debate in Malaysia about the teaching of science and mathematics in English, a qualitative study was undertaken involving a purposeful sampling of three non-physics teachers to ascertain how well equipped they were with the necessary pedagogical content knowledge relating to the teaching of the topic of "heat…

  20. Oral Language Development as a Precursor to Literacy. ERIC Topical Bibliography and Commentary.

    Science.gov (United States)

    Smith, Carl B., Ed.

    Research suggests that oral language development is directly related to literacy, and is crucial for success in learning to be literate. This topical bibliography and commentary discusses language acquisition theories, components of language, phonology in literacy, and a first-grade classroom study that explored "literate talk" in the classroom…

  1. A self-psychological approach to the study of biography: the interplay of narratives in psychoanalysis and biography.

    Science.gov (United States)

    Hershberg, Sandra G

    2009-04-01

    This chapter is an exploration of the psychoanalytic aspects of biography and the biographical aspects of psychoanalysis. The narratives that emerge from biography and psychoanalytic treatment incorporate elements of empathy, ideology (theory), and transference/countertransference and are co-constructed within an intersubjective field involving the subjectivities of both participants, the biographer and her subject and the analyst and her analysand. I will provide examples that demonstrate the way in which these processes play out in the biographical realm. Correspondingly, I will illustrate the way in which the analyst's biography and analysand's autobiography change in the course of the psychoanalytic treatment. Salient differences between biographical and psychoanalytic endeavors are also discussed.

  2. Development of terbinafine solid lipid nanoparticles as a topical delivery system

    Directory of Open Access Journals (Sweden)

    Chen Y-C

    2012-08-01

    was higher than that of Lamisil® OnceTM at 12 hours, and it was almost the same as that of Lamisil® OnceTM at 24 hours. It was concluded that the application of ACP1-GM1 for 12 hours might have an efficacy comparable to that of Lamisil® OnceTM for 24 hours, which would resolve the practical problem of the longer administration period that is necessary for Lamisil® OnceTM.Keywords: terbinafine, solid lipid nanoparticle, topical delivery system

  3. Whey protein stories - an experiment in writing a multidisciplinary biography

    DEFF Research Database (Denmark)

    Jensen, Tenna; Bechschøft, Rasmus L.; Giacalone, Davide

    2016-01-01

    This is an experimental, dual-purpose article about whey protein and how to conduct interdisciplinary analyses and writings. On the one hand, this article is a multidisciplinary commodity biography, which consists of five descriptions of whey protein written by the five different research groups...... contributes to the field of food studies with a multidisciplinary biography of whey protein - including its sensory qualities and challenges, insights into its cultural history, its nutritional value and effects on the human body and an analysis of how it is perceived by people who consume it. The biography...... thereby expands upon existing understandings of whey protein while discussing the usefulness of employing the commodity biography format in interdisciplinary writing. Moreover, the article contributes to the field of interdisciplinary research by providing a practical example of a joint publication...

  4. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    Science.gov (United States)

    Volná, M.; Látal, F.; Kubínek, R.; Richterek, L.

    2014-01-01

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems.

  5. [Urology and National Socialism. Paul Rosenstein 1875-1964, the disrupted biography of a Jewish urologist].

    Science.gov (United States)

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2011-09-01

    The biography of Paul Rosenstein (1875-1964) serves as an example of the fate of a Jewish scientist at the beginning of the twentieth century in an area of conflict between the development of urology as a specialty at greater urban hospitals, professional achievements as a surgeon and scientist, drastic breaks during Nazi era and escape from Nazi terror via New York to Brazil.

  6. The emergence and institutional co-determination of sustainability as a teaching topic in interdisciplinary science teacher education

    DEFF Research Database (Denmark)

    Rasmussen, Klaus

    2016-01-01

    This paper takes an institutional perspective on the topic of sustainability in order to analyse how this ‘idea’ enters science teacher education through an interdisciplinary approach. It shows how the development and implementation of a course for Danish pre-service teachers was conditioned......, conceptualised through a new reference model that separates the analysis from the usual sustainability dimensions. The findings reveal how sustainability as a teaching topic can be a unifying idea in an interdisciplinary setting. Disciplinary differences evidently impact course planning and implementation...

  7. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, E.R.

    1986-06-01

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.

  8. The scientometric biography of a leading scientist working on the field of bio-energy

    Energy Technology Data Exchange (ETDEWEB)

    Konur, Ozcan [Sirnak University Faculty of Engineering, Department of Mechanical Engineering (Turkey)], email: okonur@hotmail.com

    2011-07-01

    This paper presents a scientometric biography of a Turkish scientist, Prof. Dr. Ayhan Demirbas, who is a leading figure in the field of bio-energy. It describes the method and importance of doing such biographies and suggests that there are too few of them, this one being the first in this specific area. It provides insight into the individual, his work, his research and links in his field of studies and research. Prof. Dr. Demirbas has spent almost three decades in research, particularly in the field of bio-energy. He has researched and taught in the field of renewable energies including biodiesels, biofuels, biomass pyrolysis, liquefaction and gasification, biogas, bioalcohols, and biohydrogen. He has also studied a great variety of subjects, such as the development of pulp from plants, chemical and engineering thermodynamics, chemical and energy education, global climate change, drinking water and cereal analyses. He has published 454 articles as of 2011.

  9. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  10. Topical Drugs for Pain Relief

    OpenAIRE

    Anjali Srinivasan; Prashanth Shenai; Laxmikanth Chatra; Veena KM; Prasanna Kumar Rao

    2015-01-01

    Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that ...

  11. The Concept of the Interculture in Time: (Intercultural Topics in Textbooks of French as a Foreign Language

    Directory of Open Access Journals (Sweden)

    Meta Lah

    2012-12-01

    Full Text Available The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that cover a fairly long period of time – among them the textbooks by two Slovenian authors: Južnič (1938 and Grad (1954, as well as some generally-used French textbooks, such as Cours de langue et de civilisation françaises (1953, Le nouveau sans frontières (1988 and Nouveau rond point (2011. The article is based on the hypothesis that high culture is more likely to be present in the older textbooks, which are based on traditional methods, whereas in modern textbooks more popular, everyday topics can be found. It is also presumed that topics in modern textbooks are, compared to their more traditional counterparts, introduced in an intercultural manner which could encourage students to compare the culture of the foreign country with their own. Both hypotheses are partly confirmed. In Slovenian textbooks there are very few culture-based topics. On the other hand, they are present in all French textbooks, regardless of the methodology. It is true that Mauger introduces more high culture than the others and that the intercultural topics are presented only in the most recent textbook. In all the others, it is exclusively the culture of the target country that is introduced.

  12. Shildrick’s monster: exploring a new approach to difference/disability through collective biography

    OpenAIRE

    2016-01-01

    Working with memories generated in a collective biography workshop on difference/disability and drawing in particular on Shildrick’s (2002) analysis of monstrosity, this paper analyses the ambivalent processes through which difference is othered and abjected. It argues that through the process of abjection we disown for ourselves whatever qualities are being categorised as monstrous, with negative effects not just on the other, but also on the self. We look at the ambivalence of ‘reclaiming t...

  13. Eliot Freidson: progression and constraints in the biography of an intellectual

    OpenAIRE

    Pereira Neto,André

    2009-01-01

    Eliot Freidson (1923-2005) is considered one of the founders of the sociology of medicine. Both his critics and admirers in the sociological and medical fields recognize his work as an international benchmark. This paper analyzes Freidson's intellectual biography without concentrating on his ideas or their transformation over the course of time. The emphasis is on the personal constraints that marked his intellectual career within a broader context, with the many different opportunities and c...

  14. Tell me a story: MMPI responses and personal biography in the case of a serial killer.

    Science.gov (United States)

    Nichols, David S

    2006-06-01

    The interpretation of MMPI (Hathaway & McKinley, 1943) profiles has emphasized a language of pathological attribution that often serves the interests of clinical description and actuarial prediction better than those of individual case formulation and an understanding of the adaptive forces involved in the production of symptomatic behavior. In this article, I illustrate a contrasting approach, one that emphasizes MMPI items and scales as instruments of personal biography, with the case of the serial murderer Jeffrey Dahmer.

  15. One Name, Several (Wo)Men: Cultural Categories Of Identity In Virginia Woolf's Orlando: A Biography

    OpenAIRE

    Sanfelici, Aline

    2009-01-01

    This study discusses cultural categories of identity in the portrayal of Orlando in Virginia Woolf's novel, Orlando: A Biography. The analysis of the character in light of the intersections between nation, class, and gender, shows that there is a conflict in the novel as it presents at the same time a transgressive text and a normatizing subtext, a conflict that must be criticized for its implications in cultural studies regarding identity and emancipatory politics.Keywords: Virginia Woolf, O...

  16. Eine außergewöhnliche Biographie A Remarkable Biography

    Directory of Open Access Journals (Sweden)

    Andrea Rönz

    2005-03-01

    Full Text Available Erst im Alter von 44 Jahren, als ihre beiden Söhne erwachsen waren, begann die Wienerin Ida Pfeiffer Forschungsreisen zu unternehmen, die sie in den folgenden 16 Jahren zunächst ins Heilige Land und anschließend zweimal um die ganze Welt führen sollten. Die hierzu veröffentlichten Reiseberichte erfreuten sich beim zeitgenössischen Publikum großer Beliebtheit, die von den Reisen mitgebrachten Sammlungen stellten eine bedeutende Bereicherung für die Wissenschaft dar. Trotz dieser für die Mitte des 19. Jahrhunderts ungewöhnlichen weiblichen Biographie blieb Ida Pfeiffer dennoch in ihren Schriften eine Verfechterin der bürgerlichen Normen und Werte. Diesen widersprüchlichen Charakter zu beleuchten hat sich Gabriele Habinger zur Aufgabe gemacht.The Viennese born Ida Pfeiffer began undertaking research expeditions at the age of 44, after both of her sons were grown up. In the 16 years that followed, the trips led her first to the Holy Land and then finally two times around the world. The published travel reports were widely popular in the contemporary public and the collections brought back from the journeys constituted an enrichment for science. Despite this remarkable female biography for the mid-19th Century, in her writings Ida Pfeiffer remained a proponent for bourgeois morals and ideals. Gabriele Habinger made it her task to illuminate this contrasting character.

  17. Using a Process of Collective Biography Writing in Higher Education to Develop an Ability to Explore, Reveal and Critically Reflect

    Science.gov (United States)

    Wihlborg, Monne

    2013-01-01

    Teaching and learning are frequently treated as processes that are separate from each other, while teachers and learners are considered as disembodied entities with a neutral position towards the content which is negotiated. In collective biography writing (CBW), a very different approach is taken. Writing, reading and learning are seen as an…

  18. Development and in vitro assessment of alginate bilayer films containing the olive compound hydroxytyrosol as an alternative for topical chemotherapy.

    Science.gov (United States)

    Ng, Shiow-Fern; Tan, Say-Lee

    2015-11-30

    Topical chemotherapy is the application of cancer drugs directly onto the skin, which has become a standard treatment for basal cell carcinoma. Due to the promising results in the treatment of skin cancer, topical chemotherapy has recently been applied to breast cancer patients because some breast cancer tissues are only superficial. Hydroxytyrosol, a phenolic compound from olives that is present in high amounts in Hidrox(®) olive extract, has been shown to have a protective effect on normal cells and selective antitumor activities on cancerous cells. The aims of the present study were to develop an alginate bilayer film containing Hidrox(®) and to investigate its potential use as a topical chemotherapeutic agent. Alginate films were characterized for swelling and for physical, thermal, rheological, and mechanical properties. Drug content uniformity and in vitro drug release tests were also investigated. The alginate bilayer films containing Hidrox(®), HB2, showed controlled release of hydroxytyrosol at a flux of 0.094±0.009 mg/cm(2)/h. The results of the cytotoxic assay showed that the HB2 films were dose-dependent and could significantly reduce the growth of breast cancer cells (MCF-7) at 150 μg/mL for a cell viability of 29.34±4.64%. In conclusion, an alginate bilayer film containing Hidrox(®) can be a potential alternative for topical chemotherapeutic agent for skin and breast cancer treatment.

  19. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Science.gov (United States)

    Dal Mas, Juarana; Zermiani, Tailyn; Thiesen, Liliani C; Silveira, Joana LM; da Silva, Kathryn ABS; de Souza, Márcia M; Malheiros, Angela; Bresolin, Tania MB; Lucinda-Silva, Ruth M

    2016-01-01

    The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was −34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. PMID:27660442

  20. EVALUATION OF THE EFFECTIVENESS OF TOPICAL EMLA CREAM AS LOCAL ANAESTHETIC IN VENEPUNCTURE

    Directory of Open Access Journals (Sweden)

    Bodicherla Siva

    2016-05-01

    Full Text Available BACKGROUND AND OBJECTIVES The efficacy of a topical anaesthetic formulation, EMLA 5% cream (Eutectic Mixture of Local Anaesthetics in obtunding the pain produced by intravenous cannulation was determined in our study. This study aims at evaluating the eff icacy of EMLA cream in producing dermal analgesia for venous cannulation and the effect of timing of application of EMLA cream prior to cannulation. MATERIALS AND METHODS Amongst 60 patients, EMLA cream was applied for 60 minutes in 20 patients, 30 minutes in another 20 and in the remaining 20 no cream or placebo was applied. RESULTS Pain was assessed in all the groups by a 4-point rank score. It was found that patients with EMLA cream had lower pain scores and decreased haemodynamic stress response to venous cannulation when compared to the control group. INTERPRETATION AND CONCLUSION Maximum analgesia was observed in patients who had EMLA cream applied for 60 minutes. No significant side effects were seen with this formulation

  1. Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry

    DEFF Research Database (Denmark)

    Ba-Ali, Shakoor; Sander, Birgit; Brøndsted, Adam Elias;

    2015-01-01

    PURPOSE: The late post-illumination pupillary response (PIPR 10-30s ) to blue light is reduced in glaucoma, suggesting that pupillometry can be used in clinical glaucoma evaluation. Since animal studies have indicated that common anti-glaucomatous agents affect the iris muscle, we investigated...... the short-term effect of the anti-glaucoma drugs on the pupillary light reflex and in particular on the PIPR10-30s. METHODS: In this randomized, double-masked, crossover trial, pupillometry was performed before and after topical administration of latanoprost, dorzolamide, and timolol in 20 healthy subjects...... reduced by all three drugs after 3.5 h (p glaucoma medications did not interfere with the blue light elicited PIPR. Dorzolamide reduced pupil size, while timolol reduced both pupil size and maximal contraction to red...

  2. 医家传记研究的若干思考%Thoughts on physician's biography

    Institute of Scientific and Technical Information of China (English)

    朱建平

    2011-01-01

    医家传记是以医学人物为主线的医学史书,是医学史的重要内容,具有不可替代的作用,以及重要的人文和史鉴价值.指出医家传记的史学属性和一般分类.提出在对传统医家传记的回顾和剖析的基础上,继承优良传统,不断创新,内史与外史相结合,将医家回归到历史情景之中,借鉴人类学方法,写出有时代特色的医家传记——具有新视角、新方法、资料新、体例有继承有发展、观点新、结论新、成果形式多样等特点.%Biographies of Chinese medicine practitioner are historical books describing the life of medical people. As a crucial part of medical history, it is of great value for both humanity and historical references. This paper elucidates the historical property and makes classification of the biographies of Chinese medicine practitioner. It advocates the point of inheriting fine tradition and making innovations based on the review and analysis of traditional biographies of Chinese medicine practitioner. Innovative biographies of Chinese medicine practitioner, those characterized by new perspective, methodology, sources, style, viewpoints, findings and varied achievements, are made by integrative study of both formal and informal history, a careful consideration of the historical setting, and adoption of the methodology of anthropology.

  3. The Physicist and Astronomer Christoper Scheiner - Biography Letters, Works

    Science.gov (United States)

    Daxecker, Franz

    The Jesuit priest Christopher Scheiner was one of the most influential astronomers of the first half of the 17th century. He was a creative and down-to-earth natural scientist who worked in the fields of astronomy, physics, optics and ophthalmology, while following his vocations as university lecturer, church builder and pastor. In scientific matters he was Galilei's opponent. Their dispute centred on the priority of discovery in regard to the sunspots. Scheiner was not the first to discover the sunspots, but he gave the most detailed account thereofin his main work "Rosa Ursina sive Sol". He was, however, ceaseless in his defense of the geocentric system. In 1891, Anton v.Braunmühl published a biography of Father Scheiner. Ever since then, new documents have come to light, justifying the publication of a new biography. Among the documents now available is Scheiner's hitherto unknown dissertation. Notes taken during his lectures in Ingolstadt provide valuable information on astronomy using the telescope, an invention of his lifetime. His exchange of letters with personalities like Archduke Leopold V of Austria-Tyrol, with scientists like Magini, Galilei, Gassendi, Kepler and confriars Rader, Guldin, Alber, Minutuli, Cysat und Kircher is a source of precious insights. Letters to Scheiner from the Father Generals of his order display evidence of his superiors' zero tolerance for the helincentric system. They also disclose Scheiner's wish to become a missionary in China, the financial difficulties he faced while trying to find a publisher for his "Rosa Ursina sive Sol" and his personal shortcomings. A Scheiner obituary from 1650 was found in Cracow in 2001. It contains information on the troublesome last years of his life and has finally allowed us to determine the year of his birth. Scheiner's personality has been praised as well as criticized by many authors - sometimes depending on their ideological backgrounds. This holds true especially regarding the argument

  4. 人物传记研究综述%Survey of biography

    Institute of Scientific and Technical Information of China (English)

    易平; 刘宗田; 周文

    2009-01-01

    对近年来国内外人物传记研究进行了综述,从人物传记研究的开始到人物传记的相关技术与应用,力图说明自动 人物传记的研究进展,展望其未来的发展趋势.目前互联网文字信息膨胀,从多个文本中自动提取人物的传记性信息研究 有重大研究价值,不仅能够促进信息抽取和自动文摘的发展,而且能够产生一些重大应用.%A survey of the literature about the researches on biography in recent years domestic and abroad is mainly from engendering of biography to its related technique and application, review, development trend. With the expansion oflnternet text, biography sum-marization as a text about a person's information extracted from mutli-documents has important research values. Not only promote the development of information extraction and automatic abstraction but also have some significant applications.

  5. MCM-41 as a useful vector for rutin topical formulations: synthesis, characterization and testing.

    Science.gov (United States)

    Berlier, Gloria; Gastaldi, Lucia; Sapino, Simona; Miletto, Ivana; Bottinelli, Emanuela; Chirio, Daniela; Ugazio, Elena

    2013-11-30

    Rutin, the glycoside of quercetin, could be used in topical preparations because of its antioxidant and radical scavenging properties, but its employ in cosmetic and pharmaceutical products is limited by poor physico-chemical stability. These issues were addressed by preparing, characterizing and testing rutin inclusion complexes with MCM-41 mesoporous silica. The effect of surface functionalization with aminopropyl groups (NH₂-MCM-41) on the molecules properties was studied. The organic/inorganic interaction was confirmed by many techniques. In particular, the high inclusion of rutin in the pores of NH₂-MCM-41 was assessed by XRD, TGA, gas-volumetric analysis (BET), while FTIR spectroscopy allowed to analyse with great detail the molecular interaction with the inorganic surface. Rutin was stabilized against UV degradation, mostly by its inclusion in NH₂-MCM-41. Ex vivo studies showed a greater accumulation in porcine skin in the case of rutin complexed with NH₂-MCM-41. Not only antioxidant properties of rutin were maintained after immobilization but, with aminopropyl silica, the metal-chelating activity increased noticeably. The immobilization of rutin in aminopropyl silica resulted in better performance in terms of activity and photostability, suggesting the importance of functionalization in stabilizing organic molecules within silica pores.

  6. Lavender-thymol as a new topical aromatherapy preparation for episiotomy: A randomised clinical trial.

    Science.gov (United States)

    Marzouk, T; Barakat, R; Ragab, A; Badria, F; Badawy, A

    2015-01-01

    The objective of this study was to evaluate the effectiveness of topical lavender-thymol in promoting episiotomy healing. This placebo-controlled, single-blinded, randomised clinical trial involved 60 primiparous women. REEDA score was used to evaluate the outcome of the trial. On the 7th post-partum day, women in Placebo-treated group had worse Redness, Edema, Ecchymosis, Discharge and Approximation (REEDA) score of 3.93 ± 3.65 compared with those in Lavender-thymol-treated group (2.03 ± 1.7) with significant difference (P = 0.013). Visual analogue Scale (VAS) score for pain at episiotomy in Lavender-thymol-treated group was 3.5 ± 1.9, whereas in Placebo-treated group it was 2.1 ± 2.2 (p = 0.011) for dyschezia, 3.8 ± 1.7 and 2.8 ± 1.6 in Placebo- and Lavender-thymol-treated women, respectively (p = 0.023). At 7th post-partum week, dyspareunia was more severe in Placebo-treated group compared with that in Lavender-thymol-treated group (5.3 ± 2.7 vs 2.7 ± 1.5 and p episiotomy wound care with little or no expected side effects compared with that using placebo.

  7. Misselling as a New Topic of Financial Education? A Didactic Analysis of Investment Advise after the Financial Crisis

    Directory of Open Access Journals (Sweden)

    Dirk Loerwald

    2010-07-01

    Full Text Available Personal financial investments are, as a matter of course, a topic of economic education because they are a life situation which is inherently economical. In contrast, faulty advising in banks which has become focussed upon due to the extent it has played a part in the recent financial crisis is mentioned neither in curricula nor in educational text books. Numerous private funds have been exposed as unprofitable investments. One reason for this problem is to be found in the marketing staff of the banks who did not invest their customer’s funds securely enough – and the customers did not notice it. What conclusions can be drawn from this for general financial education after the financial crisis? The economic education has failed to address the topic of “faulty advising in banks” as well. On the basis of categorical economic didactics the following contribution will analyse whether one has an exemplary case here upon which students can win generalized, transferable insights. In this context, the topic of personal financial investments will be classified in an efficient manner and the risk of opportunism in advising situations will be analysed with the help of the positive principal-agent theory. The results of this analysis of informational asymmetries within financial markets give direction to the development and revision of curricula in the didactics of economic education. With the following article a sustainable theoretical fundament will be created to underscore the obligatory inclusion of this topic in curricula as well as its realisation for target groups in school text books.

  8. Biography of Joan Wint: A Principal Whose Leadership for Social Justice Transformed a Rural Jamaican High School

    Science.gov (United States)

    Oram-Sterling, Jacqueline

    2009-01-01

    This biographical study features the leadership of Joan Miller Wint, now retired, who for 23 years was principal of Denbigh High School, located in a high-poverty rural area in Jamaica. In the article I examine biography as a qualitative research strategy used in "telling" the stories of women leaders; explore the influence of Wint's…

  9. Contemporary American Success Stories. Famous People of Asian Ancestry. Volume V. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    As part of a five-volume series, this collection of biographical sketches of Asian Americans who have made contributions to life in the United States profiles individuals who are role models for all children. Written at a reading level for grades five to six, the biographies feature Asian Americans of different ethnic backgrounds, exploring the…

  10. Polish-Jewish and Jewish-Polish Biographies: Repeated Reconnaissance

    Directory of Open Access Journals (Sweden)

    Agnieszka Czyżak

    2013-01-01

    Full Text Available The article contains reflections on changes in biographical writing, especially biography of persons of heterogenous ethnic identity. The biographies are not only reconstructions of an individual’s life, but also a clear testimony and reflection of changes in collective consciousness. It turns out that biographies also discover, in a peculiar way, the author’s identity, who, in the process of selection and creation of a biographical text, reveals a part of their own history. This aspect is clearly seen in texts by second and third generation Holocaust survivors, and is demonstrated by interpretations of Magdalena Tulli’s Włoskie szpilki [Italian High Heels] and Piotr Paziński’s Pensjonat [Boarding house].

  11. Clindamycin Topical

    Science.gov (United States)

    ... topical clindamycin.you should know that abrasive or medicated soaps and skin products that contain alcohol may ... in, tightly closed, and out of reach of children. Store it at room temperature and away from ...

  12. Tretinoin Topical

    Science.gov (United States)

    ... lotions, astringents, and perfumes); they can sting your skin, especially when you first use tretinoin.Do not use any other topical medications, especially benzoyl peroxide, salicylic acid (wart remover), and dandruff shampoos containing sulfur or ...

  13. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

  14. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures

    Directory of Open Access Journals (Sweden)

    Michael A Page

    2009-10-01

    Full Text Available Michael A Page, Frederick W FraunfelderDepartment of Ophthalmology (Casey Eye Institute, Oregon Health and Science University, Portland, OR, USAPurpose: To review the current literature on safety, efficacy, and measures of surgeon and patient satisfaction with lidocaine hydrochloride gel as a tool for ocular anesthesia.Methods: Pubmed search using keywords “lidocaine gel,” “ophthalmic,” and “surgery” and compiling cross-references. Twenty-six total references were reviewed, including 15 prospective randomized controlled trials (RCTs, total N = 933, average N = 62, 6 nonrandomized prospective studies (total N = 234, average N = 39, 2 animal studies, 1 microbiologic study, and 2 letters to the editor.Results: The RCTs and nonrandomized prospective studies evaluated a number of measures including timing of onset of anesthesia, duration of anesthesia, intraoperative and postoperative pain, need for additional anesthetic applications, intracameral lidocaine levels, and adverse effects. Control groups received topical drops, subconjunctival anesthetic, retrobulbar anesthetic, or sham gel. Lidocaine gel was shown to be at least as effective for pain control as alternative therapies in all studies, with longer duration of action than topical drops. Patient and surgeon satisfaction were high, and adverse effects were rare and comparable to those for anesthetic drop formulations. Surgical settings included cataract, pterygium, trabeculectomy, strabismus, intravitreal injection, vitrectomy, and penetrating keratoplasty.Conclusions: Lidocaine gel is a safe, effective, and potentially underutilized tool for ophthalmic surgery.Keywords: lidocaine, gel, topical, ophthalmic, ocular, anesthetic

  15. Inclusion of the personal biography in daily care – a qualitative study / Einbezug der Biographie in den Pflegealltag – eine qualitative Studie

    Directory of Open Access Journals (Sweden)

    Kipfer Stephanie

    2016-12-01

    Full Text Available In Switzerland, 39% of nursing home residents have a dementia related disease. Behavioral symptoms are increasingly observed as dementia progresses. These symptoms impair patients’ quality of life and are distressing to family caregivers and nurses. A person-centered approach, which includes the resident’s individual biography, reduces such symptoms. The most current literature describes how therapists include biographical information in designated therapies. However person-centered care takes place not only in specific activities. Nurses are responsible for their patients’ care 24 hours a day.

  16. Oak leaf extract as topical antioxidant: free radical scavenging and iron chelating activities and in vivo skin irritation potential.

    Science.gov (United States)

    Almeida, Isabel F; Valentão, Patrícia; Andrade, Paula B; Seabra, Rosa M; Pereira, Teresa M; Amaral, M Helena; Costa, Paulo C; Bahia, M Fernanda

    2008-01-01

    The topical application of antioxidants may be beneficial for the protection of the skin against UV damage. An extract of Quercus robur leaves was prepared and evaluated considering its putative application as topical antioxidant. The solvent and extractive method selection was monitored by 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and polyphenols extraction (measured by the Folin Ciocalteu assay). Iron chelating activity and the phenolic composition (HPLC/DAD) were assessed on the extract obtained under optimized conditions. Skin irritation potential was investigated by performing an in vivo patch test in 19 volunteers. The extraction solvent which resulted in the highest activity was ethanol:water (4:6) and thus it was selected for further preparation of this extract. The IC50s for the iron chelation and DPPH scavenging assays were 153.8 +/- 26.3 microg x mL-1 and 7.53 +/- 0.71 microg x mL-1 (mean +/- SD), respectively. The total phenolic content was found to be 346.3 +/- 6.7 mg gallic acid equivalents (GAE)/g extract (mean +/- SD). Three phenolic compounds were identified in the extract namely: ellagic acid, rutin and hyperoside. The major identified component was ellagic acid. The patch test carried out showed that the extract can be regarded as safe for topical application.

  17. A Summary of Information on the Behavior of the Yakima Fold Belt as a Structural Entity -- Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Winsor, Kelsey; Unwin, Stephen D.

    2012-08-01

    This document is one in a series of topical reports compiled by the Pacific Northwest National Laboratory to summarize technical information on selected topics important to the performance of a probabilistic seismic hazard analysis (PSHA) of the Hanford Site. The purpose of this report is to summarize available data and analyses relevant to the Yakima Fold Belt (YFB) that may bear on the question of whether or not the YFB behaves as a single seismotectonic province in which activity along one fold structure is representative of behavior along all other fold structures. This topic has met with a fairly high level of contention in the expert community and has the potential to result in significant impacts on an evaluation of seismic hazard at the Hanford Site. This report defines the relevant alternative conceptual models relevant to this technical issue and the arguments and data that support those models. It provides a brief description of the technical issue and principal uncertainties; a general overview on the nature of the technical issue, along with alternative conceptual models, supporting arguments and information, and uncertainties; and finally, it suggests some possible approaches for reducing uncertainties regarding this issue.

  18. [Topical therapy of rosacea].

    Science.gov (United States)

    Schöfer, H

    2013-07-01

    Metronidazole and azelaic acid are the only topical medications approved for rosacea. All other topical treatments for rosacea and its special forms are used off-label. Topical steroids are not indicated in rosacea, because of their side effects (induction of steroid rosacea, high risk of facial skin atrophy, and high risk of rebound after cessation of therapy). Topical as well as systemic steroids are allowed only as initial and short term therapy for acute forms of rosacea (e.g. rosacea fulminans). Papular and pustular rosacea is the major indication for topical therapy. Sebaceous gland and connective tissue hyperplasia in glandular-hypertrophic rosacea as well as erythema in erythematous rosacea do not respond well to topical measures. A new active substance, the alpha-2-adrenoreceptor agonist brimonidine, will be approved soon for the topical treatment of erythema in rosacea. All severe forms of rosacea should initially be treated with a combination of topical and systemic agents. After improvement of the clinical symptoms, topical treatment alone is usually adequate to maintain the control.

  19. The Concept of the Interculture in Time: (Inter)cultural Topics in Textbooks of French as a Foreign Language

    OpenAIRE

    2012-01-01

    The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that co...

  20. Reclaiming and Reimagining Macro Social Work Education: A Collective Biography

    Science.gov (United States)

    Netting, F. Ellen; O'Connor, Mary Katherine; Cole, Portia L.; Hopkins, Karen; Jones, Jenny L.; Kim, Youngmi; Leisey, Monica; Mulroy, Elizabeth A.; Rotabi, Karen Smith; Thomas, M. Lori; Weil, Marie O.; Wike, Traci L.

    2016-01-01

    The authors focus on a collective biography of 12 women social work educators, all either tenured or in tenure lines, from five different universities at the time of the study. The participants represent several aspects of macro practice including administration, planning, community practice, and policy. Beginning with reflections about coming…

  1. Vadim Kuznetsov. Informal Biography by Eyes of His First Adviser

    Directory of Open Access Journals (Sweden)

    Igor V. Komarov

    2007-06-01

    Full Text Available The paper is dedicated to the memory of prominent theoretical physicist and mathematician Dr. Vadim Kuznetsov who worked, in particular, in the fields of the nonlinear dynamics, separation of variables, integrability theory, special functions. It includes his short research biography, an account of the start of his research career and the list of publications.

  2. An evaluative biography of cynical realism and political pop

    NARCIS (Netherlands)

    Kharchenkova, S.; Velthuis, O.; Berthoin Antal, A.; Hutter, M.; Stark, D.

    2015-01-01

    This chapter illustrates different regimes of justification by tracing the evaluative biography of two Chinese contemporary art styles, in order to explain their artistic and commercial success. The movements developed in the aftermath of the Tiananmen massacre, when censorship of contemporary art w

  3. 论司马迁史传观念对汪道昆散传的影响%The Influence of Sima Qian's Concepts of Historical Biography on Wang Daokun's Biography Writing

    Institute of Scientific and Technical Information of China (English)

    杨瑾

    2014-01-01

    汪道昆对司马迁《史记》的学习是多方面的,其中之一就是对其史传观念的继承和发展。这主要体现在四个方面:一、必信而传,必征而信,在散传写作中坚持考信征实的原则;二、赞扬循吏,提出养民的观点,以检讨明代吏治;三、肯定商业,提倡以儒侠之义节利;四、秉承平民史观,为平民阶层尤其是女性作传,具有补正史之阙的重要意义。此论题的研究,不仅有助于揭示汪道昆散传与《史记》的亲密关系,同时对其散传真实性、批判性、时代性等个人特点的揭示也有所裨益。%Wang Daokun learned from Sima Qian's Historical Records in many aspects, one of which is the inheritance and development of his concepts of historical biography. This is mainly reflected in four aspects: firstly, he adheres to the principle of seeking truth in his biography writing; secondly, he praises honest officials, putting forward the idea of nourishing the people to reflect upon the bureaucracy in the Ming Dynasty; thirdly, he promotes business, advocating making profits in an honest way; fourthly, he upholds the civilian historical view, writing biographies for common people especially women, which fills the gap of history books written in biographical style. Research on this topic not only helps to reveal the intimate relationship between the biography writing of Wang Daokun and Historical Records, but also explores the authenticity and the critical and contemporary spirits of his biography writing.

  4. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

    DEFF Research Database (Denmark)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún;

    2017-01-01

    , respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described...

  5. The Uncertainty Reducing Capabilities of Primary Care Physicians' Video Biographies for Choosing a New Doctor: Is a Video Worth More Than Two Hundred Words?

    Science.gov (United States)

    Perrault, Evan K; Silk, Kami J

    2016-12-01

    Choosing a primary care physician for the first time is an important decision, one that health care systems do not make particularly easy for prospective patients to make solely through the limited information provided on their websites. Without knowledge from others, a new patient is likely to have uncertainty about the physician he or she chooses. Three hundred and twenty participants completed an online experiment and were exposed to two biographies of different doctors with different media and either professional or personal information. Predictions generated by media richness theory revealed greater reductions in uncertainty for video biographies than traditional text biographies. Video biographies, and those containing personal information about the physician, were also related to higher levels of anticipated patient satisfaction and care quality. When asked to choose the physicians they would want to visit, participants overwhelmingly chose the physician with whom they perceived the greatest similarity to themselves, as well as the doctor who provided a video biography. Both theoretical and practical implications of this research are discussed.

  6. Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

    Directory of Open Access Journals (Sweden)

    Ramasamy Selvam

    2015-09-01

    Full Text Available The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, swelling of udder, consistency of milk, recovery period and product satisfaction score were assessed to evaluate the efficacy of Wisprec and reg; Spray. Topical application of Wisprec and reg; Advanced Spray have shown a significant improvement (p<0.001 in alleviation of rectal temperature, pain on palpation of udder and swelling of udder, and the consistency of milk was restored to normal after 3 to 4 days of treatment. The results demonstrate that the Wisprec and reg; Advanced spray could be considered as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs as a supportive therapy for clinical mastitis of dairy cows. [J Adv Vet Anim Res 2015; 2(3.000: 285-290

  7. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2015-01-01

    and creativity, with skillful and innovative handling of constraints seen as a prerequisite for apt creative performance. Based on a brief review of current disparate conceptualizations of constraints as both enablers and restrainers of creative activities, we begin by proposing the unifying concept ‘creativity......The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constraints’ to help establish common terminological ground. Since the presence of constraints change over time, we suggest the term ‘constrainedness’ to articulate this total constraint intensity at a given time. This allows us to introduce our main contribution, the concept ‘the sweet spot’, to address...

  8. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2016-01-01

    and creativity, with skillful and innovative handling of constraints seen as a prerequisite for apt creative performance. Based on a brief review of current disparate conceptualizations of constraints as both enablers and restrainers of creative activities, we begin by proposing the unifying concept ‘creativity......The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constraints’ to help establish common terminological ground. Since the presence of constraints change over time, we suggest the term ‘constrainedness’ to articulate this total constraint intensity at a given time. This allows us to introduce our main contribution, the concept ‘the sweet spot’, to address...

  9. Advances in studies of phospholipids as carriers in skin topical application

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective:This article provides an overview of characteristics of phospholipids,the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs,and the latest advances of the phospholipids carriers in transdermal delivery systems.The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal defivery system.

  10. New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Mogensen, Stine; Treldal, Charlotte; Feldager, Erik

    2012-01-01

    To evaluate the effect and acceptance of a new lidocaine lozenge compared with a lidocaine viscous oral solution as a pharyngeal anesthetic before upper gastrointestinal endoscopy (UGE), a diagnostic procedure commonly performed worldwide during which many patients experience severe discomfort mo...

  11. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis.

    Science.gov (United States)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún; Treldal, Charlotte; Jensen, Kenneth; Jensen, Anders Bonde; Kristensen, Claus Andrup; Jacobsen, Jette; Kreilgaard, Mads; Petersen, Janne; Andersen, Ove

    2017-01-01

    The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy individuals, and a lozenge containing 25 mg bupivacaine was administered as single dose to 10 HNC patients with oral mucositis and as multiple doses to five patients with HNC. Blood samples were collected for 6 hr from the healthy individuals and 3 hr from the patients with HNC, respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described by a two-compartment distribution model with absorption transit compartments. All the observed plasma concentrations were well below the bupivacaine concentrations (2000-2250 ng/ml) which have caused toxic symptoms. The PK model suggested that relative bioavailability was two times higher in HNC patients with oral mucositis grade 1-2 and three times higher in HNC patients with oral mucositis grade 3-4 than in the healthy individuals. Simulations showed that the plasma concentrations would be below the toxic limit after repeated dosing every second hour with 25 mg bupivacaine for five days. The 25-mg bupivacaine lozenges were safe without systemic toxic levels of bupivacaine or risk of side effects. Based on PK simulations of repeated doses of 25 mg every two hours for 16 hr a day, the lozenges can be administered with minimum risk of exceeding the toxic limit.

  12. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

    OpenAIRE

    Bernadette M. Watson; Liz Jones; Julia Cretchley

    2014-01-01

    Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that ti...

  13. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Directory of Open Access Journals (Sweden)

    Dal Mas J

    2016-09-01

    Full Text Available Juarana Dal Mas,1 Tailyn Zermiani,1 Liliani C Thiesen,1 Joana LM Silveira,2 Kathryn ABS da Silva,1 Márcia M de Souza,1 Angela Malheiros,1 Tania MB Bresolin,1 Ruth M Lucinda-Silva1 1NIQFAR, Graduate Program in Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Santa Catarina, Brazil; 2Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Paraná, Brazil Abstract: The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was -34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 µg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. Keywords: nanotechnology, nanoemulsion, Rapanea ferruginea, anti-inflammatory, phytomedicine

  14. HII mesophase as a drug delivery system for topical application of methyl salicylate.

    Science.gov (United States)

    Liang, Xin; Chen, Yu-Lin; Jiang, Xiao-Jing; Wang, Sheng-Mei; Zhang, Ji-Wen; Gui, Shuang-Ying

    2017-03-30

    The main objective of this study was to develop reversed hexagonal (HII) mesophase for transdermal delivery of methyl salicylate. The formulation was prepared, characterized and evaluated for its skin penetration in vitro and skin retention in vivo. Preliminary pharmacodynamics and skin irritation were also investigated. The formulation was identified as hexagonal structure. In vitro study exhibited that HII mesophase enhanced the skin permeation by delivering 2.61 times more methyl salicylate than the commercially available cream. Meanwhile, HII mesophase presented higher bioavailability as AUC(0-24) and AUC(0-∞) were 32.894μg·mL(-1) and 32.935μg·mL(-1) respectively, while the cream were 12.791μg·mL(-1) and 12.970μg·mL(-1). Preliminary pharmacodynamics studies demonstrated that HII mesophase possessed anti-inflammatory and analgesic effects for inhibiting paw edema, granuloma and pain. MeSa HII mesophase showed no skin irritation on the normal rat skin. Thus, HII mesophase was considered as an effective delivery system for MeSa.

  15. Formalin (0.25% as topical anti-microbial agent in burns.

    Directory of Open Access Journals (Sweden)

    Nair R

    1991-01-01

    Full Text Available In a prospective controlled trial, 0.25% formalin spray was compared with 2% silver sulfadiazine cream as the local treatment of burns. Formation and separation of eschar, infection and death rates were recorded. In the group receiving formalin, rates of formation and separation of eschar were significantly more (P less than 0.001 and P less than 0.05 resp. compared to other group. Infection rate and fatality due to infection were also reduced. Other advantages of formalin are ease of application and the low east.

  16. TOPICAL REVIEW: Metallo-supramolecular modules as a paradigm for materials science

    Directory of Open Access Journals (Sweden)

    Dirk G Kurth

    2008-01-01

    Full Text Available Metal ion coordination in discrete or extended metallo-supramolecular assemblies offers ample opportunity to fabricate and study devices and materials that are equally important for fundamental research and new technologies. Metal ions embedded in a specific ligand field offer diverse thermodynamic, kinetic, chemical, physical and structural properties that make these systems promising candidates for active components in functional materials. A key challenge is to improve and develop methodologies for placing these active modules in suitable device architectures, such as thin films or mesophases. This review highlights recent developments in extended, polymeric metallo-supramolecular systems and discrete polyoxometalates with an emphasis on materials science.

  17. Topical report on sources and systems for aquatic plant biomass as an energy resource

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, J.C.; Ryther, J.H.; Waaland, R.; Wilson, E.H.

    1977-10-21

    Background information is documented on the mass cultivation of aquatic plants and systems design that is available from the literature and through consultation with active research scientists and engineers. The biology of microalgae, macroalgae, and aquatic angiosperms is discussed in terms of morphology, life history, mode of existence, and ecological significance, as they relate to cultivation. The requirements for growth of these plants, which are outlined in the test, suggest that productivity rates are dependent primarily on the availability of light and nutrients. It is concluded that the systems should be run with an excess of nutrients and with light as the limiting factor. A historical review of the mass cultivation of aquatic plants describes the techniques used in commercial large-scale operations throughout the world and recent small-scale research efforts. This review presents information on the biomass yields that have been attained to date in various geographical locations with different plant species and culture conditions, emphasizing the contrast between high yields in small-scale operations and lower yields in large-scale operations.

  18. Rubus rosaefolius extract as a natural preservative candidate in topical formulations.

    Science.gov (United States)

    Ostrosky, Elissa Arantes; Marcondes, Elda Maria Cecilio; Nishikawa, Suzana de Oliveira; Lopes, Patricia Santos; Varca, Gustavo Henrique Costa; Pinto, Terezinha de Jesus Andreoli; Consiglieri, T Vladi Olga; Baby, Andre Rolim; Velasco, Maria Valéria Robles; Kaneko, Telma Mary

    2011-06-01

    Even though the synthetic preservatives may offer a high antimicrobial efficacy, they are commonly related to adverse reactions and regarded as having potentially harmful effects caused by chronic consumption. The development of natural preservatives provides a way of reducing the amount of synthetic preservatives normally used in pharmaceutical and cosmetic preparations. In addition, these agents have less toxic effects and represent a possible natural and safer alternative of the preservatives. The purpose of this research was to evaluate the Rubus rosaefolius Smith extract efficiency as a natural preservative in base formulations. Of the extract, 0.2% (w/w) was assayed for its effectiveness of antimicrobial protection in two different base formulations (emulsion and gel). The microbial challenge test was performed following the standard procedures proposed by The United States Pharmacopoeia 33nd, European Pharmacopoeia 6th, Japanese Pharmacopoeia 15th, and the Cosmetics, Toiletries, and Fragrance Association using standardized microorganisms. The results demonstrated that R. rosaefolius extract at the studied concentration reduced the bacterial inocula, satisfying the criterion in all formulations, even though it was not able to present an effective preservative behavior against fungi. Thus, the investigation of new natural substances with preservative properties that could be applied in pharmaceutical and cosmetic products is relevant due to the possibility of substituting or decreasing the concentration of synthetic preservatives, providing a way for the development of safer formulas for the use of consumers.

  19. Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride

    Directory of Open Access Journals (Sweden)

    Rao Kovur

    2008-01-01

    Full Text Available The present study was aimed for the development and evaluation of hydrotropic starch gels of terbinafine hydrochloride which is an allylamine derivative of antifungal agent was formulated by using corn starch and sodium salicylate as hydrotropic salt. The gels were prepared in presence and absence of propylene glycol. The prepared gels were evaluated for in vitro drug release, rheological behavior and microbial studies. The degree of increase in the drug diffusion was found to be in order corn starch gel with propylene glycol was greater than corn starch gel without propylene glycol. The microbial studies were carried out in soya bean casein digest medium with Candida albicans as test organisms and were found to be 22.86 ± 0.58 and 20.22 ± 0.65 mm for TCSG (IV and TCS (III, respectively. All the gels exhibited shear thinning. The rheogram indicated that the gel systems are pseudoplastic and exhibited thixotropy. The added propylene glycol has not appreciably altered the apparent viscosity values.

  20. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

    Directory of Open Access Journals (Sweden)

    Bernadette M. Watson

    2014-10-01

    Full Text Available Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that time was of concern to all groups in both similar and diverse ways. All professionals discussed time management, time pressures, and the difficulties of coordinating different handovers. Each professional group had its own unique perceptions and priorities about handovers. Our findings indicated that health professionals understood what was required for handover improvement but did not have the extra capacity to alter their current environment. Hospital management, with clinicians, need to implement handover schedule processes that prioritize interprofessional representation.

  1. Propylene glycol liposomes as a topical delivery system for miconazole nitrate: comparison with conventional liposomes.

    Science.gov (United States)

    Elmoslemany, Riham M; Abdallah, Ossama Y; El-Khordagui, Labiba K; Khalafallah, Nawal M

    2012-06-01

    Propylene glycol (PG)-phospholipid vesicles have been advocated as flexible lipid vesicles for enhanced skin delivery of drugs. To further characterize the performance of these vesicles and to address some relevant pharmaceutical issues, miconazole nitrate(MN)-loaded PG nanoliposomes were prepared and characterized for vesicle size, entrapment efficiency, in vitro release, and vesicle stability. An issue of pharmaceutical importance is the time-dependent, dilution-driven diffusion of propylene glycol out of the vesicles. This was addressed by assessing propylene glycol using gas chromatography in the separated vesicles and monitoring its buildup in the medium after repeated dispersion of separated vesicles in fresh medium. Further, the antifungal activity of liposomal formulations under study was assessed using Candida albicans, and their in vitro skin permeation and retention were studied using human skin. At all instances, blank and drug-loaded conventional liposomes were included for comparison. The results provided evidence of controlled MN delivery, constant percent PG uptake in the vesicles (≈45.5%) in the PG concentration range 2.5 to 10%, improved vesicle stability, and enhanced skin deposition of MN with minimum skin permeation. These are key issues for different formulation and performance aspects of propylene glycol-phospholipid vesicles.

  2. Ethosomes and liposomes as topical vehicles for azelaic acid: a preformulation study.

    Science.gov (United States)

    Esposito, Elisabetta; Menegatti, Enea; Cortesi, Rita

    2004-01-01

    The basic properties and the in vitro release rate kinetics of azelaic acid (AA), alternatively vehiculated in different phospholipid-based vesicles such as ethosomes or liposomes, were investigated. Ethosomes were produced by a simple method based on addition of an aqueous phase to an ethanol solution (comprised between 20\\% and 45%, v/v) of soy phosphatidyl choline (5%, w/w) and AA (0.2%, w/w) under mechanical stirring. Liposomes were obtained by the same composition in the absence of ethanol with the reverse-phase evaporation method. Vesicle size was measured by photon correlation spectroscopy (PCS), evidencing smaller mean diameters and narrower dimensional distributions in the case of ethosomes with respect to liposomes. In order to obtain homogeneously sized vesicles, both ethosomal and liposomal dispersions were extruded through polycarbonate membranes with pores of calibrated diameter (400 nm and 200 nm). Vesicle morphology was characterized by freeze-fracture scanning electron microscopy (SEM) showing the presence of unilamellar vesicles both in liposome- and in ethosome-based dispersions. Free energy measurements of the vesicle bilayers were conducted by differential scanning calorimetry (DSC). AA diffusion from ethosomal or liposomal dispersions and from ethosomes and liposomes incorporated in a viscous gel was investigated by a Franz cell assembled with synthetic membranes. The release rate was more rapid from ethosomal systems than from liposomal systems. In particular, ethosomes produced by the highest ethanol concentration released AA more rapidly, and the same trend was found using viscous forms.

  3. Topics in quantum foundations: Ontological models, and distinguishability as a resource

    Science.gov (United States)

    Morris, Ryan

    This thesis covers research in two disjoint research areas: The ontological model program (formerly hidden-variables program) for quantum theory has a long and noble tradition in the quantum foundations literature. By postulating a physical reality beyond the quantum state, we gain intuition on quantum phenomena and also come to understand constraints on realist interpretations of quantum theory. Bell's theorem tells us that such an underlying reality must be non-local, while the Kochen-Specker contextuality theorem abuses the classical notion that measurement should simply reveal pre-existing properties of reality. Recent research programs suggest that it is beneficial to view the quantum state as representing purely information. We show that the only current model which does this in a satisfactory manner is unable to reproduce all the statistics of quantum measurements. A recent generalization of the notion of contextuality has allowed for proofs of contextuality which differ from the original Kochen-Specker notion. We add a new result which shows that measurements in a model where the quantum state represents information must be contextual. Additionally, we refine the generalized notion of contextuality into strong and weak forms in order to parse the relationship between new and old results. Entanglement resource theory is a highly successful investigation of the usefulness of entanglement for information processing tasks. In this thesis we apply the ideas from entanglement resource theory to another resource: state distinguishability. We show analogies between distinguishability resource theory and entanglement resource theory. In particular, the analogy includes: measures which are monotonic under a class of transformations; units of a resource; and bounds on measures in terms of the amount of the unit resource needed to form states and the amount of unit resource that can be extracted from states. We show that the pairs of states which can be reversibly

  4. TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

    Science.gov (United States)

    Dorrani, Mania; Kaul, Malvika; Parhi, Ajit; LaVoie, Edmond J; Pilch, Daniel S; Michniak-Kohn, Bozena

    2014-12-10

    TXA497 is representative of a new class of guanidinomethyl biaryl compounds that exhibit potent bactericidal behavior against methicillin-resistant Staphylococcus aureus (MRSA). In this study, we compared the anti-staphylococcal, skin deposition, and skin permeation properties of TXA497 and the topical anti-MRSA antibiotic mupirocin. The results of minimum inhibitory concentration (MIC) assays revealed that TXA497 retains potent activity against MRSA that is highly resistant to mupirocin. Using Franz diffusion cells, compound deposition into human cadaver skin was evaluated, and the results showed the skin deposition of TXA497 to be significantly greater than that of mupirocin. Moreover, unlike mupirocin, TXA497 does not pass through the entire skin layer, suggesting a minimal potential for the systemic absorption of the compound upon topical administration. Additionally, antibacterial concentrations of TXA497 showed no significant toxicity to primary human keratinocytes. Given the rising levels of mupirocin resistance among MRSA populations, our results are significant in that they highlight TXA497 as a potentially useful alternative therapy for treating MRSA skin infections that are resistant to mupirocin.

  5. Cutaneous penetration of the topically applied photosensitizer Pc 4 as detected by intravital 2-photon laser scanning microscopy.

    Science.gov (United States)

    Huang, Alex Y; Myers, Jay T; Barkauskas, Deborah; Howell, Scott J; Oleinick, Nancy L; McCormick, Thomas S; Cooper, Kevin D; Baron, Elma D; Lam, Minh

    2012-09-01

    The fundamental mechanism of photodynamic therapy (PDT)-induced cell death has been characterized, but early critical PDT events in vivo remain incompletely defined. With the recent development in advanced fluorescence imaging modalities, such as intravital 2-photon laser scanning microscopy (2P-LSM), researchers are now able to investigate and visualize biological processes with high resolution in real time. This powerful imaging technology allows deep tissue visualization with single-cell resolution, thus providing dynamic information on the 3-dimensional architectural makeup of the tissue. The main goal of this study was to determine the cutaneous penetration of a topically applied photosensitizer, the silicon phthalocyanine Pc 4, into the skin of live animals and to assess the effective absorption of Pc 4 through the skin barrier. Our 2P-LSM images indicate that Pc 4 penetrates to the epidermal/dermal junction of mouse skin. The data also indicate that the degree of Pc 4 absorption is dose dependent. These findings represent initial steps that may help in improving the clinical utilization of topical Pc 4-PDT.

  6. Exploring the Abyss. The Financial Crisis of 2008 ff. as a Central Topic of Problem-Centered Social Science Education

    Directory of Open Access Journals (Sweden)

    Thorsten Hippe

    2010-07-01

    Full Text Available The financial crisis of 2008 ff. and financial crises in general should be a central topic of social science education because these crises are a recurrent and therefore structural feature of modern capitalism which has severe consequences for citizens’ quality of life. Hence, the citizenry should know how to prevent such developments which endanger its well-being in a massive way. Therefore, learners should understand the relationship between the quality of people’s everyday lives and those economic institutions and political decisions which have led to the current mess. They should be enabled to critically evaluate the current misregulation of the financial sector and the economy in order to identify possible policy measures to prevent or at least to mitigate future crises. By educating (young citizens in this way, the (future general public can – as a necessary counterweight to the lobbyism of the finance industry – exert more prudent political pressure which gives politicians a greater incentive to regulate the financial sector and the economy in a manner which is beneficial for the vast majority of the people instead of for a small elite. Two core concepts of the social sciences can be used to make the roots of the seemingly complex topic more understandable for learners: liability and inequality.

  7. Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment.

    Science.gov (United States)

    Cheng, Yung-Hsin; Tsai, Tung-Hu; Jhan, Yong-Yu; Chiu, Allen Wen-hsiang; Tsai, Kun-Ling; Chien, Chian-Shiu; Chiou, Shih-Hwa; Liu, Catherine Jui-lin

    2016-06-25

    Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment.

  8. Towards a total biography? Buty Ikara by Marin Buchowski in the light of Stachura’s writing project – a critical sketch

    Directory of Open Access Journals (Sweden)

    Borys Szumański

    2016-03-01

    Full Text Available This critical sketch is dedicated to a new biography of Edward Stachura by Marian Buchowski. A writer like Stachura, whose work is very closely intertwined with his life (at least in his declarations is a challenging protagonist for a biography. In this article, attempts are made at following the way in which Buchowski tries to bring out another human being in the text. His ideas are juxtaposed and confronted with Stachura’s own life-and-art ideas, as to him looking for various methods of recording existence was among the crucial goals of writing. As a result, the thesis is put forward that some sort of a writer’s “totality” is a feature linking Stachura and Buchowski. In this context, the biography written by Buchowski is not only of importance to research into Stachura’s writing but also a significant countersignature of his work.

  9. Superficial keratectomy and topical mitomycin C as therapy for a corneal squamous cell carcinoma in a dog.

    Science.gov (United States)

    Karasawa, K; Matsuda, H; Tanaka, A

    2008-04-01

    A 10-year-old female West Highland white terrier was presented with refractory hyperplastic keratitis of the left cornea of one month's duration. At this time, a vascularised and rough lesion 5 mm in diameter was observed on the left cornea. No other abnormality was recognised on the affected eye. The corneal neoplasm was surgically removed and histologically diagnosed as a squamous cell carcinoma. For two months after the surgery, 0.04 percent mitomycin C (MMC) eye drops were applied as adjuvant chemotherapy. Primary corneal squamous cell carcinoma with no history of keratoconjunctivitis sicca is rare in dogs. In the present report, surgical removal of the neoplasm was combined with the topical administration of the anticancer drug mitomycin C and a good prognosis was obtained. The result indicates that the combination treatment used in this case may be an appropriate therapeutic choice for corneal squamous cell carcinoma in dogs.

  10. Eliot Freidson: progression and constraints in the biography of an intellectual.

    Science.gov (United States)

    Pereira Neto, André

    2009-01-01

    Eliot Freidson (1923-2005) is considered one of the founders of the sociology of medicine. Both his critics and admirers in the sociological and medical fields recognize his work as an international benchmark. This paper analyzes Freidson's intellectual biography without concentrating on his ideas or their transformation over the course of time. The emphasis is on the personal constraints that marked his intellectual career within a broader context, with the many different opportunities and choices. It establishes the intersection between the singular trajectory of an intellectual, and the structures, processes and events in which he was immersed and which he changed by his actions.

  11. Spaces, Trajectories, Maps: Towards a World-Systems Biography of Immanuel Wallerstein

    Directory of Open Access Journals (Sweden)

    Georgi Derluguian

    2015-08-01

    Full Text Available World-systems analysis, although itself a macrohistorical perspective, eminently allows for writing individual biographies because these are structurally conditioned and historically contingent trajectories developing in specific time and space. The biographical genre seems particularly useful in intellectual popularization and in exploring how macro-level concepts behave in observed empirical situations. This article offers and demonstrates specific recommendations and methodological warnings in application to the personal trajectory of Immanuel Wallerstein, the founder of world-systems analysis as an intellectual movement.

  12. Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.

    Science.gov (United States)

    Tati, Swetha; Li, Rui; Puri, Sumant; Kumar, Rohitashw; Davidow, Peter; Edgerton, Mira

    2014-01-01

    Oropharyngeal candidiasis (OPC) is caused by the opportunistic fungi Candida albicans and is prevalent in immunocompromised patients, individuals with dry mouth, or patients with prolonged antibiotic therapies that reduce oral commensal bacteria. Human salivary histatins, including histatin 5 (Hst 5), are small cationic proteins that are the major source of fungicidal activity of saliva. However, Hsts are rapidly degraded in vivo, limiting their usefulness as therapeutic agents despite their lack of toxicity. We constructed a conjugate peptide using spermidine (Spd) linked to the active fragment of Hst 5 (Hst 54-15), based upon our findings that C. albicans spermidine transporters are required for Hst 5 uptake and fungicidal activity. We found that Hst 54-15-Spd was significantly more effective in killing C. albicans and Candida glabrata than Hst 5 alone in both planktonic and biofilm growth and that Hst 54-15-Spd retained high activity in both serum and saliva. Hst 54-15-Spd was not bactericidal against streptococcal oral commensal bacteria and had no hemolytic activity. We tested the effectiveness of Hst 54-15-Spd in vivo by topical application to tongue surfaces of immunocompromised mice with OPC. Mice treated with Hst 54-15-Spd had significant clearance of candidal tongue lesions macroscopically, which was confirmed by a 3- to 5-log fold reduction of C. albicans colonies recovered from tongue tissues. Hst 54-15-Spd conjugates are a new class of peptide-based drugs with high selectivity for fungi and potential as topical therapeutic agents for oral candidiasis.

  13. Water-filtered infrared-A (wIRA) can act as a penetration enhancer for topically applied substances

    OpenAIRE

    Sterry, Wolfram; Ackermann, Hanns; Hoffmann, Gerd; Schanzer, Sabine; Meyer, Lars; Grone, Diego; Otberg, Nina; Lademann, Jürgen

    2008-01-01

    Background: Water-filtered infrared-A (wIRA) irradiation has been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by cortisone. Aim of the study: Investigation of the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised contr...

  14. Time and death in compiled adab "biographies"

    Directory of Open Access Journals (Sweden)

    Kilpatrick, Hilary

    2004-12-01

    Full Text Available In mediaeval Arabic belles-lettres (adab, accounts of lives are usually made up of quite short reports akhbār. These akhbār. are arranged in different ways, one of which is chronological order, but the compilers of such accounts apparently accord relative insignificance to chronological order. This paper examines some "biographies" compiled by al-Ṣūlī and Abū 1-Faraj al-Iṣbahānī, showing that temporal progression can exist in a "biographical" presentation, either alone or more often combined with other ways of organising the material. It then focuses on the placing of subjects' deaths in life accounts and on how they are integrated with the rest of the material. In conclusion, I suggest that when temporal progression is absent in "biographical" presentations, this should be seen as reflecting a mediaeval Arabic approach to life writing which differs from modem expectations but has its own rationale.

    En el género árabe medieval del adab (bellas letras, los relatos de vidas están normalmente compuestos a base de pequeñas noticias (ajbār. Estos ajbār están organizados de distintas maneras, una de las cuales es el orden cronológico, aunque los compiladores de tales noticias dan aparentemente poca importancia a tal orden. Este artículo estudia algunas «biografías» recogidas por al-Ṣūlī y Abū 1-Faraŷ al-Iṣbahānī, y muestra que la progresión temporal puede existir en las presentaciones «biográficas», sola o junto con otras formas de organizar el material. En él se analiza también el lugar que las muertes de los personajes ocupan en el relato de sus vidas, y cómo se integran en el resto del material. En conclusión, propongo que si la progresión temporal está ausente en las presentaciones «biográficas», ello se debe a la manera característica que la literatura árabe medieval tiene de enfocar los relatos de vida, que posee su propia lógica, aunque difiera

  15. Water-filtered infrared-A (wIRA can act as a penetration enhancer for topically applied substances

    Directory of Open Access Journals (Sweden)

    Sterry, Wolfram

    2008-07-01

    increased penetration depth compared to the non-irradiated skin (mode A: The ratio of the amount of the dye in the deeper (second 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians and interquartile ranges for mode A of 0.017 (0.007/0.050, for mode B of 0.084 (0.021/0.106, for mode C of 0.104 (0.069/0.192 (difference between modes: p=0.0112, significant; comparison mode A with mode C: p<0.01, significant. In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation. Discussion: The better penetration of the hydrophilic dye fluorescein after or during skin irradiation (modes B and C can be explained by increased hydration of the stratum corneum by irradiation with wIRA. Conclusions: As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances – in the first case even of thermolabile substances – with a broad clinical relevance as a contact free alternative to an occlusive dressing.

  16. A case of topical opioid-induced delirium mistaken as behavioural and psychological symptoms of dementia in demented state.

    Science.gov (United States)

    Ito, Go; Kanemoto, Kousuke

    2013-06-01

    In Japan, indications for opioid analgesics, once exclusively used as pain killers for patients suffering from malignant cancer, have been expanded for a wide range of pain. Herein we report a patient with opioid-induced delirium associated with the administration of buprenorphine patches that was well below the indicated therapeutic range limit. An 82-year-old woman was referred to us from an orthopaedic practitioner for uncontrollable behavioural problems apparently caused by the beginning of dementia; the patient had gradually developed disorientation, visual hallucinations, and delusions. Laboratory and imaging findings excluded common causes of delirium including Alzheimer's disease and diffuse Lewy body disease. Detailed questioning revealed that the patient's confused state appeared following a buprenorphine patch dose increase and subsequently disappeared after administration was stopped. Delirium has not been reported as a side-effect in clinical trials of buprenorphine patches. However, our findings in this case show that even topical opioids can precipitate the development of a delirious state in elderly patients.

  17. Preoperative subconjunctival injection of mitomycin C versus intraoperative topical application as an adjunctive treatment for surgical removal of primary pterygium

    Directory of Open Access Journals (Sweden)

    Ehab M Ghoneim

    2011-01-01

    Materials and Methods : Seventy eyes of 70 patients with primary pterygia were randomly allocated to two groups. The first group (Group A, 35 eyes received 0.1 ml of 0.15 mg/ml of subconjunctival MMC injected into the head of the pterygium 24 h before surgical excision with the bare sclera technique. The second group (Group B 35 eyes underwent surgical removal with the bare sclera technique with intraoperative application of MMC (0.15 mg/ml over bare sclera for 3 min. The study was performed between March 2007 and December 2008, and follow up was performed for 1 year postoperatively. Differences between frequencies in both groups were compared by the Chi-square test or Fisher exact test. Differences between means in both groups were compared by Student′s t-test. P 0.05. Postoperatively, scleral thinning occurred in one eye in each group that resolved by 5 months postoperatively. No serious postoperative complications occurred in either group. Conclusion : Preoperative local injection of 0.15 mg/ml MMC is as effective as intraoperative topical application of 0.15 mg/ml MMC for preventing pterygium recurrence after surgical removal.

  18. Biografia coletiva, engajamento e memória: a miséria do mundo Collective biography, commitment and memory: the weight of the world

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Montagner

    2009-01-01

    Full Text Available Este trabalho procura relacionar a proposta de biografia coletiva de Pierre Bourdieu e suas possibilidades teóricas com a questão histórica do "engajamento" político dos cientistas, o que acaba por nos inserir no debate sobre o que é um intelectual, tema caro a muitos autores. Como exemplo polêmico, a forma elaborada desse engajamento por Pierre Bourdieu, em seu livro A miséria do mundo, é debatida neste artigo. Por fim, o interesse foi elaborar, à luz dessas ideias, uma proposta coerente de análise das trajetórias sociais e histórias de vida dos indivíduos inseridos em grupos comuns, assumindo como bases o conceito de memória coletiva de Halbwachs e de persona coletiva de Boltanski.This text aims to relate Pierre Bourdieu's proposal of collective biography and its theoretical possibilities to the historical question of the political 'commitment' of scientists, which pitches us once again into the debate on what is an intellectual, a key topic for many authors. As a polemical example, the article discusses the form in which this commitment is elaborated by Pierre Bourdieu in his book The weight of the world. It then seeks to develop these ideas into a coherent proposal for analyzing the social trajectories and life histories of individuals inserted in social groups, taking as its lead Halbwachs's concept of collective memory and Boltanski's notion of collective persona.

  19. Biography and Brief Chronology of Zhang Jian%张坚传记及年谱

    Institute of Scientific and Technical Information of China (English)

    于广杰; 王晓曦

    2014-01-01

    清代戏曲家张坚一生著述颇丰,尤以《玉燕堂四种曲》知名当世。然而后代岁月流转,资料湮没,人们只知其曲而不知其人。今裒辑资料成张坚传记及年谱简编,以期为治曲考古之助。其间对于张坚生平事迹、家世背景、与鄂尔泰之因缘、与袁枚和杨潮观等人之交往一一考索,于张坚一生际遇及心态演变也做了相应描述。%Zhang Jian, a dramatist of Qing Dynasty, had published extensively in his lifetime. His Yuyantangsizhongqu is particularly well known. As the passage of time, his biographical information lost, people only know his dramas, rather than understand his life. In order to help researchers understand his dramas and biographies, we collect the information, written a biography and chronicle of Zhang Jian. Examine the life story of Zhang Jian’s, his family background and contacts with Ertai, Yuan Mei, Yang Chaoguan. Also describes the fate of a lifetime Zhang Jian and his psychological world.

  20. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC).

    Science.gov (United States)

    Fang, Jia-You; Fang, Chia-Lang; Liu, Chi-Hsien; Su, Yu-Han

    2008-10-01

    Solid lipid nanoparticles (SLN) were developed by using Precirol ATO 5 as the solid core of the particles for topical psoralen delivery. Nanostructured lipid carriers (NLC) consisting of Precirol and squalene, a liquid lipid, were also prepared for comparison. SLN and NLC showed respective mean particle sizes of approximately 300 and 200nm, respectively. Viscosity, polarity, and differential scanning calorimetry (DSC) studies were performed to characterize the physicochemical properties of the SLN and NLC. The viscosity of all nanoparticulate systems exhibited Newtonian behavior except the NLC with Tween 80 and soybean phospholipids as the emulsifiers (NLC-Tw). According to the DSC thermograms, the melting peak of Precirol shifted from 58 to 55 degrees C after incorporating squalene into the solid lipid cores (of NLC), which suggests defects in the crystalline lattice of the lipid cores and smaller particle sizes. Three psoralen derivatives for psoriasis treatments were loaded in SLN and NLC to examine their ability to permeate skin. The permeability of psoralens increased in the order of 8-methoxypsoralen (8-MOP)>5-methoxypsoralen (5-MOP)>4,5,8-trimethylpsoralen (TMP). Enhanced permeation and controlled release of psoralen delivery were both achieved using the NLC. The in vitro permeation results showed that NLC-Tw increased the 8-MOP flux 2.8 times over that of a conventional emulsion. Hyperproliferative or psoriasis-like skin produced by repeated strippings in the dorsal skin of nude mouse was also used as a permeation barrier. The results showed that the entrapment of 8-MOP in nanoparticulate systems could minimize the permeation differentiation between normal and hyperproliferative skin compared to the free drug in an aqueous control.

  1. Sports Biographies of African American Football Players: The Racism of Colorblindness in Children's Literature

    Science.gov (United States)

    Winograd, Ken

    2011-01-01

    This is an exploratory study of racism in a genre of children's literature that has been largely overlooked by research and teaching in multicultural children's literature: sports biographies and, in particular, the biographies of African American professional football players. By examining the race bias of this genre of children's literature, the…

  2. "He Said It All in the Painting": Using Visual Art to Interpret and Create Biography

    Science.gov (United States)

    Lea, Susan G.; Sipe, Lawrence R.; O'Loughlin, Tricia

    2011-01-01

    This article is centrally focused on teaching biography to second grade children in new and intriguing ways. In this article, the authors discuss the use of a multimodal integrated visual art and literacy curriculum in student investigations, interpretations, and writing of biography. Section one describes the wider project of conceptualizing an…

  3. Biography, Identity, and Inquiry: The Making of Teacher, Teacher Educator, and Researcher

    Science.gov (United States)

    Skerrett, Allison

    2008-01-01

    This is a self-study of my professional and cultural biography and identity, a history which directed me first toward the work of urban teaching and then into teacher education and research into comparative educational issues of racial and national identity. I use this inquiry to demonstrate how biography and identity influences the lived…

  4. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  5. Making Sense of Scientific Biographies: Scientific Achievement, Nature of Science, and Storylines in College Students' Essays

    Science.gov (United States)

    Hwang, Seyoung

    2015-01-01

    In this article, the educative value of scientific biographies will be explored, especially for non-science major college students. During the "Scientist's life and thought" course, 66 college students read nine scientific biographies including five biologists, covering the canonical scientific achievements in Western scientific history.…

  6. The Modernization Concept as an Integrative Framework for the Methodology of Studying Topical Issues in Russian History

    Directory of Open Access Journals (Sweden)

    Yuri N. Smirnov

    2016-10-01

    Full Text Available The article is devoted to a number of methodological and concrete historical questions raised in the monograph by Boris Mironov, “The Russian Empire: From Tradition to Modernity.” The monograph is based on the modernization concept. The variety of methods and techniques borrowed by the author from different scientific disciplines and schools, but which demonstrate their usefulness, provide a reason to call his approach “integrative.” Smirnov shares Mironov’s perspective on the possibility of determining the laws of Russia’s historical path, and on the positive prospects for Russia’s movement upon it. Particular attention is paid to how Mironov examines and interprets the course of Russian colonization, its influence on the internal processes in society in general, and on the fate of specific regions and the ethnic groups. In Mironov’s opinion, the inclusion of new lands in Russia has had generally beneficial effects for the country as a whole and for the people who inhabit it. Smirnov engages in a thought experiment in order to assess in how far Mironov’s conclusions are applicable to the southeast of Russia. The results prove the validity of the conclusions and their applicability to research of other colonized territories. The reviewer recognizes as valid the opinion that the economic reserves of serfdom had not been exhausted by the middle of the 19th century. The liberation of the peasants was caused by many factors, among which moral and cultural reasons were not in the last place. The imperial “Enlightened” bureaucracy became the leader of peasant and other reforms. The article expressed disagreement that the strengthening of the position of the nobility and their power over the peasants in the 18th century was determined by the decisive role of the guard in palace coups. Mironov’s book will stimulate new research and discussions on topical issues of Russian history.

  7. Irritantcy potential and sub acute dermal toxicity study of Pistacia lentiscus fatty oil as a topical traditional remedy.

    Science.gov (United States)

    Djerrou, Zouhir; Djaalab, Hdria; Riachi, Foulla; Serakta, Mennouba; Chettoum, Aziez; Maameri, Zineb; Boutobza, Badaoui; Hamdi-Pacha, Youcef

    2013-01-01

    The current study was undertaken to assess safety of Pistacia lentiscus fruits fatty oil (PLFO) as a topical traditional remedy. A primary skin and eye irritation tests were conducted with New Zealand white rabbits to determine the potential for PLFO to produce irritation from a single application. In addition, a sub acute dermal toxicity study was performed on 18 NZW rabbits to evaluate possible adverse effect following application of PLFO for 28 days. Based on the results of the current study, PLFO is classified as slightly irritating to the skin and the eye of rabbits (Primary Irritation Index (P.I.I.) = 1.037; Ocular Irritation Index (O.I.I.) = 5.33 at 1 h). In the sub-acute toxicity test, PLFO produced neither mortality nor significant differences in the body and organ weights between control group and treated rabbits. However, a reversible irritant contact dermatitis was observed in the treated areas from the end of the second week of application until the end of experiment. This local phenomenon was accompanied by a significant skin thickening (P≤0.01) since the 12(th) day (ANOVA, F = 11, 07143, P = 0, 00765) which is confirmed with an inflammatory granuloma in histological study. Haematological analysis and blood chemistry values of the 2 groups showed no significant differences in any of the parameters examined. In summary, PLFO is minimally irritating to the eye and skin after a single exposure, but it may cause irritant contact dermatitis and a reversible thickening of skin after prolonged use.

  8. Human Progress Never Rolls in on Wheels of Inevitability: Biographies of Martin Luther King, Jr., in the Classroom.

    Science.gov (United States)

    Kazemek, Francis E.

    1990-01-01

    Presents resources for teaching about Dr. Martin Luther King, Jr. Outlines criteria for selecting biographies for children and young adults. Identifies problems in certain biographies of King, and recommends high quality biographies of King. Discusses exercises for integrating themes from King's life into the classroom. (RW)

  9. Efficacy of ACA strategies in biography-driven science teaching: an investigation

    Science.gov (United States)

    MacDonald, Grizelda L.; Miller, Stuart S.; Murry, Kevin; Herrera, Socorro; Spears, Jacqueline D.

    2013-12-01

    This study explored the biography-driven approach to teaching culturally and linguistically diverse students in science education. Biography-driven instruction (BDI) embraces student diversity by incorporating students' sociocultural, linguistic, cognitive, and academic dimensions of their biographies into the learning process (Herrera in Biography-driven culturally responsive teaching. Teachers College Press, New York, 2010). Strategies have been developed (Herrera, Kavimandan and Holmes in Crossing the vocabulary bridge: differentiated strategies for diverse secondary classrooms. Teachers College Press, New York, 2011) that provide teachers with instructional routines that facilitate BDI. Using systematic classroom observations we empirically demonstrate that these activate, connect, affirm, strategies are likely to be effective in increasing teachers' biography-driven practices. Implications for theory and practice are discussed.

  10. Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides

    Science.gov (United States)

    Briz, Verónica; Sepúlveda-Crespo, Daniel; Diniz, Ana Rita; Borrego, Pedro; Rodes, Berta; de La Mata, Francisco Javier; Gómez, Rafael; Taveira, Nuno; Muñoz-Fernández, Mª Ángeles

    2015-08-01

    The development of topical microbicide formulations for vaginal delivery to prevent HIV-2 sexual transmission is urgently needed. Second- and third-generation polyanionic carbosilane dendrimers with a silicon atom core and 16 sulfonate (G2-S16), napthylsulfonate (G2-NS16) and sulphate (G3-Sh16) end-groups have shown potent and broad-spectrum anti-HIV-1 activity. However, their antiviral activity against HIV-2 and mode of action have not been probed. Cytotoxicity, anti-HIV-2, anti-sperm and antimicrobial activities of dendrimers were determined. Analysis of combined effects of triple combinations with tenofovir and raltegravir was performed by using CalcuSyn software. We also assessed the mode of antiviral action on the inhibition of HIV-2 infection through a panel of different in vitro antiviral assays: attachment, internalization in PBMCs, inactivation and cell-based fusion. Vaginal irritation and histological analysis in female BALB/c mice were evaluated. Our results suggest that G2-S16, G2-NS16 and G3-Sh16 exert anti-HIV-2 activity at an early stage of viral replication inactivating the virus, inhibiting cell-to-cell HIV-2 transmission, and blocking the binding of gp120 to CD4, and the HIV-2 entry. Triple combinations with tenofovir and raltegravir increased the anti-HIV-2 activity, consistent with synergistic interactions (CIwt: 0.33-0.66). No vaginal irritation was detected in BALB/c mice after two consecutive applications for 2 days with 3% G2-S16. Our results have clearly shown that G2-S16, G2-NS16 and G3-Sh16 have high potency against HIV-2 infection. The modes of action confirm their multifactorial and non-specific ability, suggesting that these dendrimers deserve further studies as potential candidate microbicides to prevent vaginal/rectal HIV-1/HIV-2 transmission in humans.

  11. Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.

    Directory of Open Access Journals (Sweden)

    Ramesh K Wali

    Full Text Available Head and neck squamous cell carcinoma (HNSCC is a major cause of morbidity and mortality underscoring the need for safe and effective chemopreventive strategies. Targeting epidermal growth factor receptor (EGFR is attractive in that it is an early critical event in HNSCC pathogenesis. However, current agents lack efficacy or have unacceptable toxicity. Several groups have demonstrated that the over-the-counter medication, polyethylene glycol (PEG has remarkable chemopreventive efficacy against colon carcinogenesis. Importantly, we reported that this effect is mediated through EGFR internalization/degradation. In the current study, we investigated the chemopreventive efficacy of this agent against HNSCC, using both the well validated animal model 4-NQO (4-nitroquinoline 1-oxide rat model and cell culture with the human HNSCC cell line SCC-25. We demonstrated that daily topical application of 10% PEG-8000 in the oral cavity (tongue and cavity wall post 4NQO initiation resulted in a significant reduction in tumor burden (both, tumor size and tumors/tumor bearing rat without any evidence of toxicity. Immunohistochemical studies depicted decreased proliferation (number of Ki67-positive cells and reduced expression of EGFR and its downstream effectors cyclin D1 in the tongue mucosa of 4NQO-rats treated with PEG. We showed that EGFR was also markedly downregulated in SCC-25 cells by PEG-8000 with a concomitant induction of G1-S phase cell-cycle arrest, which was potentially mediated through upregulated p21(cip1/waf1. In conclusion, we demonstrate, for the first time, that PEG has promising efficacy and safety as a chemopreventive efficacy against oral carcinogenesis.

  12. Stephen Hawking and the universe a biography

    CERN Document Server

    Sztajnkrycer, Ben

    2012-01-01

    ABOUT THE BOOK Stephen William Hawking is arguably the most famous scientist since Albert Einstein. He is a theoretical physicist, applied mathematician, and cosmologist, but he is best known to non-scientists as the author of "A Brief History of Time," his best-selling book that unraveled the origins of the universe. His fame is so far-reaching that he has appeared on such popular entertainment as "Star Trek: The Next Generation" and "Late Night with Conan O'Brien." He has even been animated as a character on "The Simpsons." Hawking is also well known for being the longest-living survivor

  13. Explaining Today's Physics Through History and Biography

    Science.gov (United States)

    Lindley, David

    2014-03-01

    Quantum computers, string theory, holographic universes - to the general audience, today's physics can be as mystifying as it is fascinating. But modern ideas evolved from an earlier phase of physics - Newtonian mechanics, simple cause and effect - that is in principle easier for the non-expert to grasp. I have found that writing about physics from a historical and biographical perspective is an effective way to convey modern thinking by explaining where it comes from - it is a way of carrying the reader from concepts that make intuitive sense to ideas that seem, on first encounter, utterly bizarre. Smuggling explanations into stories satisfies the reader's desire for narrative - bearing in mind that narrative can include the evolution of ideas as well as tales about intriguing and original people.

  14. Abraham Pais Prize: Physics, History, and Biography

    Science.gov (United States)

    Cassidy, David C.

    2014-03-01

    Each of these fields differs in obvious and not so obvious ways from the others in terms of goals, methods, purposes, and perspectives. Yet each also holds much in common with the others. Having worked in these fields and crossed the boundaries between them, I will explore in this talk not only the similarities and differences I have encountered on this journey, but also my growing appreciation of how these fields together provide a unified perspective on physics as a science and a disciple and as a vital component of our broader human culture.

  15. Mark Zuckerberg biography of an accidental billionaire

    CERN Document Server

    Melendez, Macie

    2012-01-01

    ABOUT THE BOOK Mark Zuckerberg is one of the world's youngest billionaires, thanks to his role in co-founding social networking site, Facebook. As Facebook has grown exponentially since its founding in 2004 (with 845 million monthly active users as of the end of December 2011 according to Facebook), Zuckerberg's popularity has also flown through the roof. Interesting on so many levels, Zuckerberg's quick rise to fame is one that the mass media and general public just can't get enough of. There's his Harvard education, his invention of one of the most popular Internet sites this world has ev

  16. Biographies of Stone and Landscape: Lithic Scatters

    Directory of Open Access Journals (Sweden)

    Clive Jonathon Bond

    2009-09-01

    Full Text Available Lithic scatters are complex palimpsests. Cores, waste and tools, when interpreted in their landscape context often appear to constitute multiple episodes of activity. These seasonal and cyclical episodes represent different lengths of duration and/or function. This article deals with assemblages from central Somerset, UK, containing artefacts of flint and others of greenstone and sandstone and argues that discarded/deposited artefacts sometimes served as a resource for cultural memory.

  17. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature...... is largely ignored by the critics. Thus, the article tests how topics may work in creative nonfiction. Two Danish bestsellers belonging to the genre, Frank’s Mit smukke genom ( My Beautiful Genome), about genomics, and Buk-Swienty’s Slagtebænk Dybbøl ( ‘Slaughter-bench Dybbøl’), a history book, are chosen...... as cases and analysed using a slightly modified motif model by Johansen. The result is that in both books the main topic is treated from a double perspective, but also that six out of seven secondary topics, or motifs, are treated as well. It is concluded that also in a topical sense creative nonfiction...

  18. (Anti-Biography and Neo-Impressionism

    Directory of Open Access Journals (Sweden)

    Foa, Michelle

    2012-07-01

    Full Text Available This article analyzes neo-impressionism in relation to the biographical model of art criticism and art history that became increasingly prevalent in France over the course of the 19th century. Examining the critical response to the neo-impressionists, as well as some of their pictures and writings, I argue for the centrality of questions of authorship, individuality, and subjectivity to the group and its reception. I identify a distinctly anti-biographical tendency in the movement, one that disquieted the critics and led them to try and re-inscribe biographical meaning back into the work of Georges Seurat. Indeed, though Seurat instituted a divide between his work and his life in a variety of ways, he also insisted throughout his career on his paternity over the neo-impressionist method. In all of these ways, the relationship between the self and art was a significant and problematic issue for the neo-impressionists and the critics around them.

  19. A Textual Research on the Fictional Works in the Biographies of Hermits%《高士传》编创之小说考辨

    Institute of Scientific and Technical Information of China (English)

    马振方

    2012-01-01

    今存皇甫谧《高士传》为上古至曹魏九十六人作传,应为史书。由于材料杂取子史,以至于《庄》、《列》寓意之作,常将杜撰的人物、事迹视为真人实事,为之立传,混迹其中。这些人事原为某种寓意的例证,不很完整,更不充分独立,多为原书的小说成分,被编人本传,添头加尾,添枝加叶,或以多篇文字缀合,成为各自独立、自成起讫的虚拟人物传略,遂成早期小说作品。%The extant Biographies of Hermits (《高士传》) by Huangfu Mi, which contains biographies of 96 people from the antiquity to the Wei Period, should be considered as a history book. As its source materials came from works by various masters of philosophy, from historical texts, and also from such allegorical works as Zhuangzi(《庄子》) and Liezi(《列子》), the author took the fabricated people and stories as real ones, created biographies for them, and mixed them in this book. These stories were originally allegorical, fictional, but neither complete nor independent. Yet they were included in biographies with additions to their beginning or end, or with the combination of several stories, thus becoming independent, complete biographies of fictional people, and consequently turning into early fictional works.

  20. Shakespearian Biography and the Geography of Collaboration

    Directory of Open Access Journals (Sweden)

    Katherine Scheil

    2016-03-01

    Full Text Available The essay looks at the possibilities for reconciling two vibrant strands of Shakespeare studies. Many scholars have persuasively argued that Shakespeare’s plays were created within the collaborative environment of the London playhouses, involving a variety of influences within the performance network of early modern London. Conversely, recent archaeological work at New Place, Shakespeare’s home in Stratford, convincingly maintains that Shakespeare would have spent the majority of his time here, and not in London. Could Shakespeare have collaborated if he was not based in London? And if his primary residence was in Stratford, how could he have contributed as a collaborator with other playwrights? Resolving the contradictions between these two divergent models is particularly urgent for biographers, who have to chart a geography of Shakespeare’s writing career amid his two locales.

  1. Concept mapping as a method to teach an evidence-based educated medical topic: a comparative study in medical students

    OpenAIRE

    Saeidifard, Farzane; Heidari, Kazem; Foroughi, Moein; Soltani, Akbar

    2014-01-01

    Background The objective of this study was to compare concept mapping with lecture-based method in teaching of evidence based educated topic to medical students. Methods This randomized controlled trial was carried out on medical students during sixth year of 7-year MD curriculum clerkship phase. Cluster randomization was used to divide students into intervention and control groups. Both groups, at the beginning, were taught “Diabetic Ketoacidosis” (DKA) using evidence-based tool named Critic...

  2. High-Altitude Aggressions and Physiological Degeneration? The Biography of “Climate” as an Object of Scientific Inquiry in Colombia During the 19th and the Early 20th Centuries

    Directory of Open Access Journals (Sweden)

    Stefan Pohl-Valero

    2015-10-01

    Full Text Available Objective: to show the role played by experimental physiology in the way of understanding the effects of high-altitude climates on the functioning of the human body and the possibilities of progress of the Colombian nation throughout the 19th and early 20th centuries. Content: the transformation of the concept of climate as an object of scientific inquiry is explored over the studied period. This is done by analyzing investigations on respiratory capacity, nutrition and metabolism, blood chemistry and heart function in people of the eastern range of the Colombian Andes. Conclusions: beyond an institutional or disciplinary history of physiology, this article shows that some practices of experimental physiology played a role in the process of represent­ing the Colombian nation, territory, and population. The inhabitants of the Andean highlands were understood not only in terms of race and innate abilities, but also in terms of social classes and organic transformations. The idea that there was a supposed process of “physiological de­generation”, decreasing the efficiency of high-altitude workers, was tried to compensate through a “rational diet”.

  3. Metronidazole Topical

    Science.gov (United States)

    ... anticoagulants ('blood thinners') such as warfarin (Coumadin) and vitamins.tell your doctor if you have or have ever had a central nervous system disease, liver or blood disease, or Crohn's disease.tell your doctor if you are pregnant, ...

  4. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris.

    Science.gov (United States)

    Silva, Elton Luiz; Carneiro, Guilherme; De Araújo, Lidiane Advíncula; Trindade, Mariana de Jesus Vaz; Yoshida, Maria Irene; Oréfice, Rodrigo Lambert; Farias, Luis de Macêdo; De Carvalho, Maria Auxiliadora Roque; Dos Santos, Simone Gonçalves; Goulart, Gisele Assis Castro; Alves, Ricardo José; Ferreira, Lucas Antônio Miranda

    2015-01-01

    Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles represent an alternative to overcome these side-effects. This work aims to develop solid lipid nanoparticles loaded with retinoic acid and lauric acid and evaluate their antibacterial activity. The influence of lipophilic stearylamine on the characteristics of solid lipid nanoparticles was investigated. Solid lipid nanoparticles were characterized for size, zeta potential, encapsulation efficiency, differential scanning calorimetry and X-ray diffraction. The in vitro inhibitory activity of retinoic acid-lauric acid-loaded solid lipid nanoparticles was evaluated against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. High encapsulation efficiency was obtained at initial time (94 ± 7% and 100 ± 4% for retinoic acid and lauric acid, respectively) and it was demonstrated that lauric acid-loaded-solid lipid nanoparticles provided the incorporation of retinoic acid. However, the presence of stearylamine is necessary to ensure stability of encapsulation. Moreover, retinoic acid-lauric acid-loaded solid lipid nanoparticles showed growth inhibitory activity against Staphylococcus epidermidis, Propionibacterium acnes and Staphylococcus aureus, representing an interesting alternative for the topical therapy of acne vulgaris.

  5. Automatic Labelling of Topics with Neural Embeddings

    OpenAIRE

    Bhatia, Shraey; Lau, Jey Han; Baldwin, Timothy

    2016-01-01

    Topics generated by topic models are typically represented as list of terms. To reduce the cognitive overhead of interpreting these topics for end-users, we propose labelling a topic with a succinct phrase that summarises its theme or idea. Using Wikipedia document titles as label candidates, we compute neural embeddings for documents and words to select the most relevant labels for topics. Compared to a state-of-the-art topic labelling system, our methodology is simpler, more efficient, and ...

  6. Cet article vise à aborder la relation biographique comme rémunération d’une « injustice » commise à l’égard de l’écrivain biographié ou de son entourage. À travers l’analyse de trois exemples d’écrits biographiques — Alabama Song de Gilles Leroy sur Zelda Fitzgerald, La vocation du bonheur de Karin Reschke sur Henriette Vogel et Le médecin de Lord Byron de Paul West sur John Polidori — où il s’agit de réparer un oubli non mérité, une occultation volontaire ou encore une méprise fondamentale, je tenterai de cerner les enjeux d’une entreprise qui, à distance, vise à réhabiliter des figures historiques tout autant qu’à s’inscrire en faux contre les forces qui les marginalisent, notamment au sein des biographies des « héros » de l’histoire littéraire. This paper endeavours to consider the relationship between the biographer and the writer-biographee as a form of reparation for an injustice committed toward the latter and his/her entourage. I will examine three examples of biographical works—Alabama Song by Gilles Leroy on Zelda Fitzgerald, La vocation du bonheur by Karin Reschke on Henriette Vogel and Lord Byron’s Doctor by Paul West on John Polidori—in which the aim is to redress an undeservedly overlooked detail, an intentional oversight or a fundamentally mistaken assessment of the subject. In so doing, I will attempt to delimit the challenges of the biographical endeavour that seeks, from a distance, to rehabilitate historical figures as much as to denounce the forces that have marginalised them, in particular in the biographies of the so-called “heroes” of literary history.

    Directory of Open Access Journals (Sweden)

    Robert Dion

    2010-12-01

    Full Text Available Cet article vise à aborder la relation biographique comme rémunération d’une « injustice » commise à l’égard de l’écrivain biographié ou de son entourage. À travers l’analyse de trois exemples d’écrits biographiques — Alabama Song de Gilles Leroy sur Zelda Fitzgerald, La vocation du bonheur de Karin Reschke sur Henriette Vogel et Le médecin de Lord Byron de Paul West sur John Polidori — où il s’agit de réparer un oubli non mérité, une occultation volontaire ou encore une méprise fondamentale, je tenterai de cerner les enjeux d’une entreprise qui, à distance, vise à réhabiliter des figures historiques tout autant qu’à s’inscrire en faux contre les forces qui les marginalisent, notamment au sein des biographies des « héros » de l’histoire littéraire. This paper endeavours to consider the relationship between the biographer and the writer-biographee as a form of reparation for an injustice committed toward the latter and his/her entourage. I will examine three examples of biographical works—Alabama Song by Gilles Leroy on Zelda Fitzgerald, La vocation du bonheur by Karin Reschke on Henriette Vogel and Lord Byron’s Doctor by Paul West on John Polidori—in which the aim is to redress an undeservedly overlooked detail, an intentional oversight or a fundamentally mistaken assessment of the subject. In so doing, I will attempt to delimit the challenges of the biographical endeavour that seeks, from a distance, to rehabilitate historical figures as much as to denounce the forces that have marginalised them, in particular in the biographies of the so-called “heroes” of literary history.

  7. Topical ketoprofen patch.

    Science.gov (United States)

    Mazières, Bernard

    2005-01-01

    Although oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of a variety of acute and chronic pain conditions, their use may be associated with serious systemic adverse effects, particularly gastrointestinal disorders. In order to minimise the incidence of systemic events related to such agents, topical NSAIDs have been developed. Topical NSAIDs, applied as gels, creams or sprays, penetrate the skin, subcutaneous fatty tissue and muscle in amounts that are sufficient to exert a therapeutic effect on peripheral and central mechanisms in the absence of high plasma concentrations. Data indicate that topical NSAIDs are effective at relieving pain in a number of acute and chronic pain indications. This review article discusses the pharmacokinetics, efficacy and tolerability of a new formulation of ketoprofen available as a topical patch. The topical patch containing ketoprofen 100mg as the active principle has been developed using a novel delivery system that dispenses therapeutic doses of the drug directly to the site of injury. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally. Because the patch facilitates ketoprofen delivery over a 24-hour period, the drug remains continually present in the tissue subjacent to the site of application. High tissue but low plasma ketoprofen concentrations mean that while tissue concentrations are high enough to exert a therapeutic effect, plasma concentrations remain low enough to not result in systemic adverse events caused by elevated serum NSAID levels. Phase III clinical trials in patients with non-articular rheumatism and traumatic painful soft tissue injuries showed that the topical ketoprofen patch was significantly more effective than placebo at

  8. An Account of ... William Cullen: John Thomson and the Making of a Medical Biography.

    Science.gov (United States)

    Shuttleton, David E

    2014-01-01

    John Thomson's An Account of the Life, Lectures and Writings of William Cullen (1832; 1859) remains a primary source for the career of the most influential academic physician in eighteenth-century Scotland and is also a significant work of medical history. But this multi-authored text, begun around 1810 by the academic surgeon, John Thomson, but only completed in 1859 by Dr David Craigie, has its own complex history. This chapter addresses what this history can reveal about the development of medical biography as a literary genre. It argues that the Account is a hybrid work shaped by a complex array of practical, domestic, intellectual, and professional pressures, as Thomson, in seeking to bolster his own career, was caught between the demands of Cullen's children for a traditional "Life" and his own more theoretical and socio-cultural interests.

  9. Land use and cover change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change : issues for implementation

    NARCIS (Netherlands)

    Fresco, L.O.; Berg, van den M.M.; Zeijl-Rozema, van A.E.

    1996-01-01

    The integration study 'Land Use and Cover Change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change (NRP)' aims at identifying research fields in which the NRP can contribute most effectively to the international scientific know-how

  10. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 1: Achillea millefolium-Curcuma longa.

    Science.gov (United States)

    Calapai, Gioacchino; Miroddi, Marco; Minciullo, Paola L; Caputi, Achille P; Gangemi, Sebastiano; Schmidt, Richard J

    2014-07-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 1: Achillea millefolium L.-Curcuma longa L.

  11. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia.

    Science.gov (United States)

    Gangemi, Sebastiano; Minciullo, Paola L; Miroddi, Marco; Chinou, Ioanna; Calapai, Gioacchino; Schmidt, Richard J

    2015-04-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 2: Echinacea purpurea Moench-Lavandula angustifolia Mill.

  12. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  13. Transportation: Topic Paper E.

    Science.gov (United States)

    National Council on the Handicapped, Washington, DC.

    As one of a series of topic papers assessing federal laws and programs affecting persons with disabilities, this paper reviews the issue of transportation services. In the area of urban mass transit, four relevant pieces of legislation and public transportation accessibility regulations are cited, and cost issues are explored. Paratransit systems,…

  14. BIOGRAPHY OR A DECLARATION OF PHILOSOPHICAL AMBITION: HOW TO READ ECCE HOMO BY NIETZSCHE

    Directory of Open Access Journals (Sweden)

    Lúcia Schneider Hardt

    2015-06-01

    Full Text Available This article discusses the book Ecce homo, by Nietzsche, defending that the text is an interpretation of the philosopher himself on her own thought, not to give the book a sacred tone, nor to stress his biography, but affirming a dissonant thought that indicates his philosophical ambition. With no constraints, Nietzsche presents his conflicts, passions, deceptions, announcing a tragic dimension of life that is not guided by pessimism, but by happiness of living intensely, understanding suffering as one of the facets of life. His philosophy derives from a life demand, transfigured by an experience that promotes self cultivation and the possibility of “becoming what one really is” through the “applying” of one’s own genealogic method.

  15. A prospective comparison of topical feracrylum citrate versus adrenaline as haemostatic agent in hypospadias surgery in children

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Laddha

    2014-01-01

    Full Text Available Background: A comparative study of topical feracrylum citrate versus adrenaline to minimise haemorrhage-related complications in paediatric hypospadiac patients. Patients and Methods: A total of 108 consecutive paediatric hypospadiac patients (48 in the study group and 60 control - random allocation were studied. In the study group, 1% feracrylum citrate solution was used and adrenaline (1:100,000 in controls. Results: Among the study group, average number of blood-soaked gauge pieces were 2.95/patient, correlating with average intraoperative blood loss of 14.74 ml. In controls, average blood-soaked gauge pieces were 4.83/patient corresponding to an average blood loss of 24.13 ml. The average amount of blood loss during surgery in the <5 years was 13.70 ml/patient in the feracrylum group, while the same in the adrenaline group was 23.45 ml. Average duration of surgery was 79 min in the study group, while the same in controls was 94 min/patient. Average number of cauterisations was 0.255/patient in the study group and 0.583/patient among controls. Postoperative haematoma was seen in 8% study group compared with 18% controls. Wound oedema appeared in 4.17% study group and 11.67% controls. Postoperative complications were higher among controls. Conclusions: Feracrylum is more efficient and safer topical haemostatic agent than adrenaline. It reduced the frequency of cauterisation and tissue damage, intraoperative blood loss, and postoperative complications.

  16. Discovering health topics in social media using topic models.

    Directory of Open Access Journals (Sweden)

    Michael J Paul

    Full Text Available By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM, as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689 and allergies (r = 0.810 temporal surveillance data, as well as exercise (r =  .534 and obesity (r =  -.631 related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  17. A life of Erwin Schroedinger; Erwin Schroedinger. Eine Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Walter J.

    2012-07-01

    Erwin Schroedinger (1887-1961) was a pioneer of quantum physics, one of the most important scientists of the 20th century at all and - a charming Austrian. He was a man with a passionate interest in people and ideas. Mostly known he became by his representation of quantum theory in the form of wave mechanics, for which he got the Nobel prize for physics and naturally by the famous thought experiment ''Schroedinger's cat''. Walter Moore's biography is very close to the person of Schroedinger and presents his scientific work in the context of his private friendships, his interest in mysticism, and in front of the moving background of the political events in Germany and Austria.

  18. Eine außergewöhnliche Biographie

    Directory of Open Access Journals (Sweden)

    Andrea Rönz

    2005-03-01

    Full Text Available Erst im Alter von 44 Jahren, als ihre beiden Söhne erwachsen waren, begann die Wienerin Ida Pfeiffer Forschungsreisen zu unternehmen, die sie in den folgenden 16 Jahren zunächst ins Heilige Land und anschließend zweimal um die ganze Welt führen sollten. Die hierzu veröffentlichten Reiseberichte erfreuten sich beim zeitgenössischen Publikum großer Beliebtheit, die von den Reisen mitgebrachten Sammlungen stellten eine bedeutende Bereicherung für die Wissenschaft dar. Trotz dieser für die Mitte des 19. Jahrhunderts ungewöhnlichen weiblichen Biographie blieb Ida Pfeiffer dennoch in ihren Schriften eine Verfechterin der bürgerlichen Normen und Werte. Diesen widersprüchlichen Charakter zu beleuchten hat sich Gabriele Habinger zur Aufgabe gemacht.

  19. Biographies of Romanian Physicists. Vol. 1. Outstanding Romanian Physicists

    Science.gov (United States)

    Ionescu-Pallas, Nicolae

    1998-01-01

    Biographies and the most important works of the following physiscists are written: Bacaloglu Emanuel (1830-1891), Farkas Gyula (1847-1930), Hepites Stefan (1851-1922), Negreanu Dimitrie (1858-1908), Bungeteanu Dimitrie (1860-1932), Miculescu Constantin (1863-1937), Hurmuzescu Dragomir (1865-1954), Donici Nicolae (1874-1956), Maior Augustin (1882-1963), Oteteleseanu Enric (1885 - 1948), Demetrescu Gheorghe (1885 - 19690, Badarau Eugen (1997-1975), Procopiu Stefan (1890-1972), Athanasiu Gheorghe (1893-1972), Marian Victor (1896-1971), Huluibei Horia (1896-1972), Proca Alexandru (1897-1955), Vencov Stefan (1899-1955), Ionescu Theodor (1899-1988), Ionescu Aurel (1902-1954), Manu Gheorghe I. (1903-1954), Herovanu Mircea (1904-1960), Agarbiceanu Ion (1907 - 1971), Titeica Serban (1908-1985), Auslander Iosif (1911-1978), Ciorascu Florin (1914-1977).

  20. La biographie, un genre historique retrouvé

    OpenAIRE

    Bennassar, Bartolomé

    2014-01-01

    L’historiographie anglo-saxonne a toujours réservé une place de choix à la biographie. En revanche, celle-ci, après avoir connu quelques livres à succès, tel le Napoléon de Jacques Bainville (1931), a longtemps été considérée comme un genre mineur par l’histoire universitaire, en France et dans d’autres pays latins, tels l’Espagne et l’Italie. On assurait parfois qu’elle était réservée aux « historiens des alcôves ». Tout récemment, l’un des directeurs des Éditions Fayard, Denis Maraval (2004...

  1. N-pyridinyl-indole-3-(alkyl)carboxamides and derivatives as potential systemic and topical inflammation inhibitors.

    Science.gov (United States)

    Duflos, M; Nourrisson, M R; Brelet, J; Courant, J; LeBaut, G; Grimaud, N; Petit, J Y

    2001-06-01

    N-substituted-(indol-3-yl)carboxamides 10-15 and alkanamides 16-18 were prepared starting from the corresponding acids and submitted to screening for evaluation of their anti-inflammatory activity. None of the considered carboxamides exhibited significant inhibitory effect in the carrageenin-induced rat paw oedema after oral administration of 0.1 mM x kg(-1); nevertheless introduction of an alkyl chain, leading to alkanamides 16-18, induced moderate to high activity: 46-95% inhibition. The efficacy of these compounds in the inhibition of topical inflammation was confirmed by measuring reduction of ear thickness in the acute tetradecanoyl phorbol acetate (TPA)-induced mouse ear swelling assay. Preliminary pharmacomodulation brought to the fore that toxic effects induced, at 0.4 mM x kg(-1), by N-(pyridin-4-yl)(indol-3-yl)propanamide (17) could be attenuated or suppressed by 5-fluorination or introduction of a methoxycarbonylborane moiety, leading to 18 and 21.

  2. Formulation and in vitro evaluation of clotrimazole gel containing almond oil and tween 80 as penetration enhancer for topical application.

    Science.gov (United States)

    Nawaz, Asif; Jan, Syed Umer; Khan, Nauman Rahim; Hussain, Abid; Khan, Gul Majid

    2013-05-01

    Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermal and transdermal products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to develop Clotrimazole gel and to evaluate the effect of almond oil and tween 80 (in different concentrations), on the permeation of drug through rabbit skin in vitro. In order to investigate the effect of penetration enhancers used in this study on the permeation of Clotrimazole through sections of excised rabbit skin, Franz diffusion cell was employed. Sample solution was withdrawn at specific time interval up to 24 h. Significant difference in permeation among the eight formulations was seen in the study. The permeation profile of various formulations also showed that the added enhancers in individual batches affected the permeation of the drug. Drug permeation increased with increased concentration of Tween 80 and decreased concentration of almond oil. Furthermore, almond oil combined with tween 80 showed synergistic effect. The clotrimazole gels were successfully formulated and could be beneficial for topical use.

  3. Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation

    Directory of Open Access Journals (Sweden)

    Žugić Ana R.

    2015-01-01

    Full Text Available Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature. Nevertheless, there are no papers dealing with formulation of its isolates into topical preparations for treatment of skin infections. In present study, alkyl polyglucoside (APG - based vehicle was developed as carrier of U. barbata CO2-supercritical extract (U-SE that demonstrated the best antimicrobial potential in preliminary screening. For comparison, chosen extract in the same concentration and using the same procedure was incorporated into a pharmacopoeial vehicle. Comparative evaluation of physicochemical stability, efficiency and safety proved APG-based vehicle to possess certain preferential features as carrier of U-SE compared to the reference one, composing a topical formulation with potential clinical relevance in treatment of skin infections. [Projekat Ministarstva nauke Republike Srbije, br. III45017 i br. TR34031

  4. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - Part 3: Mentha × piperita - Solanum dulcamara.

    Science.gov (United States)

    Calapai, Gioacchino; Minciullo, Paola L; Miroddi, Marco; Chinou, Ioanna; Gangemi, Sebastiano; Schmidt, Richard J

    2016-03-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph - now (since 2015)(†) called a European Union herbal monograph - has been produced. Part 3: Mentha × piperita L.-Solanum dulcamara L.

  5. Topical report review status

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies.

  6. Use of abnormal and health psychology as topics in a classroom format to reduce alcohol and other drug abuse among college students at risk.

    Science.gov (United States)

    Miley, W M

    2001-12-01

    This study was done to assess whether classes containing topics derived from two college courses, Abnormal Psychology and Health Psychology, could be used in a class room format to reduce alcohol and other drug abuse among at-risk college students. Topics covered included stress and stress management, alcohol and other drug use and abuse, chronic illnesses and psychological disorders that develop from an unhealthy lifestyle, and factors that play a role in good health and well-being. Students were enrolled in a semester-long course for college credit as an alternative to punitive sanctions for on-campus alcohol violations and other drug violations. The Midwest Institute on Drug Use Survey and the CORE Alcohol and Drug Survey were administered on the first and last days of class. Analysis indicated a significant self-reported reduction in drug use and associated negative symptoms and behavioral effects. Women were more likely to report reductions in drug use than men.

  7. Review of biographies of doctors in Chinese history%中国历代医家传记述评

    Institute of Scientific and Technical Information of China (English)

    朱建平

    2011-01-01

    After reviewing the biographies of doctors recorded in official history of China and books mentioned the biographies,it was seen that biographies of doctors in Chinese history are mainly composed of a resume of their life and medical achievements.Although a variety of other aspects,such as social,family and education background,personality,hobby,speciality,travel experience,medical ethics,comments and achievements outside medicine,which could make those figures more vivid,none of these has been described in detail.Biographies about doctors of Traditional Chinese Medicine (TCM) should be both scientific and popular,and of literary merit on the basis of validity.Biographers should know both doctors' medical achievements and the background of the era,combine the internal history and external history and find the relationship between them to make reasonable explanations.%回顾正史中的医家传记以及历史上有关医家传记的专著或专篇,可知医家传记主体部分是传主生平和医学成就,其他部分则内容广泛,涉及社会、家庭背景、蒙童求学、个性、喜恶、特长、游历、医德、简评、医学外成就等,虽着墨较少,但可使传主形象更为丰满、鲜活.中医医家传记的写法,应在真实性前提下,科学性与普及性有机结合,力求写得更有文采.传记作者应内史与外史相结合,深入理解和掌握传主的医学工作,同时了解传主所处的时代、社会环境等,找到内史与外史某些要素的联系,传主工作与生活的联系,并且统一起来进行合理的解释.

  8. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques.

    Science.gov (United States)

    Pan, H J; Wilding, G; Uno, H; Inui, S; Goldsmith, L; Messing, E; Chang, C

    1998-08-01

    The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human prostate cancer PC3 cell line by cotransfection with wild-type androgen receptor (wt AR) and an androgen-responsive reporter (MMTV-ARE-CAT) construct. Anti-and rogens, hydroxyflutamide, and Casodex, and the antiestrogen, genistein, were studied in parallel for comparison with RU58841. The wt AR was activated only by the androgen dihydrotestosterone (DHT). Neither the anti-androgens nor antiestrogen can enhance AR transcriptional activity at 10(-11)-10(-7)M in PC3 cells. Hydroxyflutamide, RU58841, and Casodex, but not genistein, displayed competitively suppressive effects on DHT activation of wt AR. The potency of RU58841 was comparable to that of hydroxyflutamide. From this result, topical application of RU58841, which is considered to be a potential therapy for skin diseases, may induce systemic side effects. However, RU58841, on topical application, revealed a potent increase in density, thickening, and length of hair in the macaque model of androgenetic alopecia, whereas no systemic effects were detected. Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism.

  9. Human and animal health on three continents--a biography of the early life of Karl Friedrich Meyer (1884-1974).

    Science.gov (United States)

    Pospischil, Andreas

    2015-08-01

    Karl Friedrich Meyer (KF) was born and educated as a veterinarian in Europe; he researched infectious diseases in Europe, South Africa and the United States. He is one of the true forefathers of the 'one health-one medicine' concept. The broad scope of his research covered botulism, leptospirosis, brucellosis, plague, ornithosis, Western equine encephalitis, mussel poisoning and clostridia. This manuscript adds some more details of his early biography.

  10. A Natural History of an Environmentalist: Identifying Influences on Pro-sustainability Behavior Through Biography and Autoethnography

    Directory of Open Access Journals (Sweden)

    Evangelos Manolas

    2013-01-01

    Full Text Available This natural history of an environmentalist uses autoethnography through biographical interview to investigate the contextual analysis of influences affecting active pro-sustainability behavior, which is interpreted as environmentalism. Education for sustainability categories of environmental, socio-cultural, political and economic factors were used to identify factors that interact to influence affective and cognitive domains, which affect environmentalist behavior. These influences in reality operated symbiotically but for purposes of analysis they have been portrayed sequentially. The portrayal of the autoethnographer's vocabulary of motives and identity theory applied to group commitment were used as analytic tools. The research methodology employed provides a strategy for investigating biography, which gives access to lived experience as a basis for understanding factors influencing environmentalism. Processes of metacognition and reflexivity, supported by critical engagement with co-researchers, provide access to deep analysis of the biography. Whilst it was not possible to make statistical generalizations from a single case study it was possible to make limited qualitative generalizations, or in other words "moderatum generalizations." Subsequent examination of the natural histories of other life-long environmentalists would certainly not reveal detailed similarities in terms of specific biographical occurrences. However, the abstract categories of influence outlined provide a useful template for further investigating the process of activist identity development which we know little about at the present time. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1301151

  11. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    Diclofenac topical gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the ... the knees, ankles, feet, elbows, wrists, and hands. Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain ...

  12. The Category Biography and Its Writing Features in Historical Records%《史记》类传及其撰写特点

    Institute of Scientific and Technical Information of China (English)

    肖振宇

    2014-01-01

    In some biographies of Historical Records, Sima Qian used the category biography t .But until now people cannot i-dentify which biographies belong to the category biography .Through analysis and exploration , this paper reaches a conclusion that there are all together eleven biographies in Historical Records that fall into the category biography .They are:The Queen's Family, The Biography oft he Assassins, The Biography of the Honest Government Officials, The Biography of the Scholars, The Biography of the Cruel Government Officials, The Biography of Paladins, The Biography of Sycophants, The Biography of the Jesters, The Biogra-phy of the Fortune Tellers, The Biography of Guice, The Biography of the Money-Makers.The character category biographies of Re-cords of the Historian have two distinctive features:comments before narration and the combination of details and omissions .%司马迁在《史记》的一些纪传中,使用了类传方式写人叙事,但《史记》中到底哪些传纪属于类传,至今人们没有完全搞清楚。《史记》中的类传共有《外戚世家》《刺客列传》《循吏列传》《儒林列传》《酷吏列传》《游侠列传》《佞幸列传》《滑稽列传》《日者列传》《龟策列传》《货殖列传》等11篇。《史记》中的人物类传具有先议后叙、详略结合两个鲜明突出的特点。

  13. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  14. Topics in field theory

    CERN Document Server

    Karpilovsky, G

    1989-01-01

    This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.

  15. FOREWORD: Peter Clay Eklund: a scientific biography Peter Clay Eklund: a scientific biography

    Science.gov (United States)

    Cole, Milton W.; Crespi, Vincent H.; Dresselhaus, Gene F.; Dresselhaus, Mildred S.; Mahan, Gerald D.; Sofo, Jorge O.

    2010-08-01

    Peter Eklund grew up in Southern California and attended the University of California at Berkeley, majoring in physics. After working for one year at the Lockheed Missile and Space Company in Sunnyvale, California, he left to pursue graduate studies at Purdue University. There he carried out PhD research in strongly correlated electron and phonon systems under the supervision of J M Honig and L L van Zandt. Peter joined the group of Millie and Gene Dresselhaus at MIT in 1974 as a Postdoctoral Fellow after one year as an instructor at the University of Kentucky. At MIT, he continued work on strongly correlated systems in collaboration with Professor David Adler (who had an adjoining office), but for the most part he got excited about sp2 carbon systems and graphite intercalation compounds, a new research direction which the Dresselhaus group had started one year before Peter's arrival at MIT. Over the next 35 years Peter, Millie and Gene co-authored over 50 research articles, several review articles, and a big nine-hundred-and-fifty page book. In 1974, they saw graphite intercalation compounds as a long-neglected research direction of great promise. They studied these new materials together over the next 16 years, focusing on their optical spectroscopy. Their pioneering vibrational spectroscopy studies provided a means to characterize the fundamental properties of carbon materials. Optical spectroscopy became a centerpiece in the research portfolios of all three, both when they were together at MIT and after Peter left for the University of Kentucky in 1977 to start his independent career as an Assistant Professor of Physics. Peter became a full Professor at Kentucky in 1986. He continued to work with Millie and Gene and also acquired an ever-expanding network of students, postdocs and collaborators. As each new carbon nanostructure emerged—graphite intercalation compounds, fullerenes, carbon nanotubes, and most recently graphene—Peter was at the cutting edge

  16. Linguistic Extensions of Topic Models

    Science.gov (United States)

    2010-09-01

    class of corpora and would help monolingual users to explore and understand multilingual corpora. In this chapter, we develop multilingual LDAWN, an... Multilingual Priors As in the case of a monolingual walk over the concept hierarchy, we want to provide guidance to the multilingual model as to which parts...topic models for new datasets, such as unaligned multilingual corpora, and combine topic models with other sources of information about documents’ context

  17. Lytton Strachey : l’historien intime de deux reines Lytton Strachey’s Intimate Biographies of Two Queens

    Directory of Open Access Journals (Sweden)

    Jeannine Hayat

    2007-01-01

    Full Text Available The British writer Lytton Strachey (1880-1932 wrote biographies of the two most eminent Queens of England: Queen Victoria (1921 and Elizabeth and Essex (1928. The two books made him a very famous historian. However, he would personally have preferred to be admired for his poetry or his plays, for he was a very gifted literary author. Nevertheless many of Strachey’s readers have appreciated his conception of biography, as a means of personal confession while studying the destiny of a public figure. Indeed the Stracheyan way of life, free from Victorian moral standards and guided by the rules of the Bloomsbury group, inspired his story of Victoria and Elizabeth. Both Queens at the end of their lives and at the height of their power carried on strange love affairs: Victoria with her Scottish gillie and Elizabeth with the Earl of Essex, thirty years her younger. In fact, both romances subtly reflect Strachey’s own love affairs. He was himself engaged in a kind of common life with Dora Carrington— the painter, thirteen years younger than him, with whom he was not sexually involved— while he engaged in numerous homosexual love affairs.

  18. 论人物传记与“传记体小说”的区别%On the Distinctions between Biographies and Biographical Novels

    Institute of Scientific and Technical Information of China (English)

    孟晖; 贺桂花

    2015-01-01

    Since the beginning of the new era , biography writing is flourishing in China and the life stories of some celebrities are spreading .At the same time , some problems emerge in biography writing and some biographical novels are regarded as biographies .Though being similar in form , they are essentially different in that biographies must be authentic while biographical novels can be imaginative or imaginary .We should avoid deconstructing the biographical writings from the postmodernism point of view and keep its unique stylistic characteristics and position .%进入新时期,我国文坛传记创作呈现持续升温的现象。在一定程度上,一些文化名人的生平事迹得以传播。但传记创作也出现一些误区。一些以传记形式出现的小说,也被看成是人物传记。两者虽然形式上相似,其实有着本质的不同,传记讲究真实性,而传记体小说可大量采用想象、虚构等文学手法,混淆两者容易以讹传讹,使得一些史料真假莫辨。同时还要警惕后现代主义对传记写作的解构,使传记保有其独特的文体特征和地位。

  19. Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dube syndrome: a double-blind placebo-controlled randomized split-face trial.

    Directory of Open Access Journals (Sweden)

    Lieke M C Gijezen

    Full Text Available BACKGROUND: Birt-Hogg-Dubé syndrome (BHD is a rare autosomal dominant disorder characterised by the occurrence of benign, mostly facial, skin tumours called fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax and an increased renal cancer risk. Current treatments for fibrofolliculomas have high rates of recurrence and carry a risk of complications. It would be desirable to have a treatment that could prevent fibrofolliculomas from growing. Animal models of BHD have previously shown deregulation of mammalian target of rapamycin (mTOR. Topical use of the mTOR inhibitor rapamycin is an effective treatment for the skin tumours (angiofibromas in tuberous sclerosis complex, which is also characterised by mTOR deregulation. In this study we aimed to determine if topical rapamycin is also an effective treatment for fibrofolliculomas in BHD. METHODS: We performed a double blinded, randomised, facial left-right controlled trial of topical rapamycin 0.1% versus placebo in 19 BHD patients. Trial duration was 6 months. The primary outcome was cosmetic improvement as measured by doctors and patients. Changes in fibrofolliculoma number and size were also measured, as was occurrence of side effects. RESULTS: No change in cosmetic status of fibrofolliculomas was reported in the majority of cases for the rapamycin treated (79% by doctors, 53% by patients as well as the placebo treated facial sides (both 74%. No significant differences between rapamycin and placebo treated facial halves were observed (p = 1.000 for doctors opinion, p = 0.344 for patients opinion. No significant difference in fibrofolliculoma number or change in size of the fibrofolliculomas was seen after 6 months. Side effects occurred more often after rapamycin treatment (68% of patients than after placebo (58% of patients; p = 0.625. A burning sensation, erythema, itching and dryness were most frequently reported. CONCLUSIONS: This study provides no evidence that

  20. The school textbook as a research topic in the history of education: notes to the geography text

    OpenAIRE

    Jorge Alejandro Aguirre Rueda

    2015-01-01

    The school textbook as memory space, ideological and pedagogical tool vector has emerged as a new piece of research for historians. Undervalued for a long time, today it brings critical information to understand the initial processes of socialization that took place within schools. One of them, indeed, has been the textbook of geography, which is shown as vehicle tool for many national messages about the territory and the population. It was evident that in Spain, Mexico, Guatemala, Colombia, ...

  1. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B. [Massachusetts General Hospital, Harvard Medical School, Dept. of Dermatology, Boston, MA (United States); Cuevas, J. [Hospital Universitario de Guadalajara, Dept. of Pathology, Guadalajara (Spain); Villarrubia, V.G. [I.F. Cantabria SA, Medical Dept., Immunology Sect., Madrid (Spain)

    1997-12-31

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8{+-}0.59 times and MPD increased 2.75{+-}0.5 and 6.8{+-}1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au). 50 refs.

  2. Topical erythropoietin as a novel preventive and therapeutic agent in bisphosphonate-related osteonecrosis of the jaw

    Directory of Open Access Journals (Sweden)

    Pantea Nazeman

    2016-01-01

    Full Text Available Introduction: One of the most common side effects of bisphosphonate intake is osteonecrosis of the jaw (ONJ which may develop following dentoalveolar interventions. Despite the vast available protocols, there is no clear guideline in the management of this condition. In osteonecrosis, the number and proliferation of bone-forming cells as well as vascularity are disturbed. Erythropoietin (EPO is a hematopoietic hormone with angiogenic, osteogenic, and antiapoptotic properties. The Hypothesis: It is suggested to utilize poly lactic-co-glycolic acid hydrogel containing 1500-3000 IU/kg EPO following dentoalveolar surgery in samples receiving bisphosphonates as a preventive or therapeutic agent. Evaluation of the Hypothesis: Considering the pathophysiology of ONJ and therapeutic properties of EPO, it is assumed that EPO may be effective in treatment of ONJ. Furthermore, as a preventive measure, utilizing EPO following dentoalveolar surgery may be beneficial in the patients at risk of ONJ.

  3. The school textbook as a research topic in the history of education: notes to the geography text

    Directory of Open Access Journals (Sweden)

    Jorge Alejandro Aguirre Rueda

    2015-01-01

    Full Text Available The school textbook as memory space, ideological and pedagogical tool vector has emerged as a new piece of research for historians. Undervalued for a long time, today it brings critical information to understand the initial processes of socialization that took place within schools. One of them, indeed, has been the textbook of geography, which is shown as vehicle tool for many national messages about the territory and the population. It was evident that in Spain, Mexico, Guatemala, Colombia, Ecuador, Chile and Argentina such themes and uses were recurrent and provided similar services. However, it was found that the vast majority of historical studies are still overestimating the role of the textbook, as already denounced Alain Choppin.

  4. Synergistic Combination of Chitosan Acetate with Nanoparticle Silver as a Topical Antimicrobial: Efficacy against Bacterial Burn Infections ▿

    OpenAIRE

    Huang, Liyi; Dai, Tianhong; Xuan, Yi; Tegos, George P.; Michael R. Hamblin

    2011-01-01

    Chitosan and nanoparticle silver are both materials with demonstrated antimicrobial properties and have been proposed singly or in combination as constituents of antimicrobial burn dressings. Here, we show that they combine synergistically to inhibit the in vitro growth of Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria (Pseudomonas aeruginosa, Proteus mirabilis, and Acinetobacter baumannii), as judged by bioluminescence monitoring and isobolographi...

  5. Mental Mechanisms for Topics Identification

    Directory of Open Access Journals (Sweden)

    Louis Massey

    2014-01-01

    Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

  6. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Bahrami A

    2008-04-01

    Full Text Available ANGIPARSTM is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARSTM and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities."nTwenty one patients with diabetic foot ulcers were divided into 3 groups. The first group received 100 mg of oral ANGIPARSTM twice a day for 6 weeks in addition to conventional therapies. In the second group, ANGIPARSTM gel 3% was added to the oral form of the same product besides the conventional therapies for the same period of time. Finally, in the third group which was considered as control, only conventional therapies were performed. The patients were followed for 6 weeks. Parameters such as granulation tissue formation, skin epithelization, and wound surface areas changes were analyzed to determine the effectiveness of the compound in wounds healing. Furthermore, drug safety was assessed by monitoring adverse events and by clinical and laboratory evaluations."nThe study data showed significant differences between the intervention and control groups with respect to efficacy and tolerability. In each intervention group, primary wound healings occurred following 2 weeks. Complete wound healing which was greater than 70% improvement in wounds surface areas was achieved in 83% and 100% of group 1 and group 2 participants, respectively after 6 weeks. On the other hand, at the same period of time, only 22.2% of patients in control group revealed complete healing. Therefore, ANGIPARSTM had significant positive effect in increasing the incidence of complete wound closure compared with control group (p = 0.042. However, our evaluations indicated that adding topical treatment with 3% gel once a day to the oral therapy with the same product did not make

  7. Exploring Pre-Service Teachers' Historical Thinking through the Cooperative Biography: A Design-Based Research Study

    Science.gov (United States)

    Fuentes, David A.

    2012-01-01

    Through Design-Based Research (Cobb, et al., 2003), this study explores the intended outcomes and processes of the Cooperative Biography project. This research provides an "iterative analysis" (Cobb, et al., 2003) of how pre-service teachers experienced history while engaged in a Cooperative Biography, in a teacher-education setting.…

  8. Representacion E Identidad: Content Analysis of Latina Biographies for Primary and Preadolescent Children Published 1955-2010

    Science.gov (United States)

    Lara, Margaret A.

    2012-01-01

    This study discusses the results of a content analysis of 75 Latina biographies for primary and pre-adolescent students that were published over a 16-year period, spanning from 1995 to 2010. Significant to this study was how Latinas were represented in the biographies and what changes can be seen over time. Using a rubric based on research by…

  9. Integrierter Sprach- und Sachunterricht im Spanischkurs fuer Fortgeschrittene am Beispiel des Themas "La Emigracion actual" (Integrated Instruction in Language and Realia in the Advanced Spanish Course, with, as an Example, the Topic "The Present Emigration")

    Science.gov (United States)

    Christ, Ingeborg

    1975-01-01

    Advanced-level Spanish courses often lead outside everyday situations. Text, topic, language content and skill orientation form a complex of conditions for advanced learning. Consequences of significance for the learning process are discussed, with the topic "la emigracion actual" ("the present emigration") as a base. (Text is in German.) (IFS/WGA)

  10. Implementation of Biography Based Neural Clustering (BBNC with Genetic Processing for tumor detection from medical images

    Directory of Open Access Journals (Sweden)

    Kaur Chandanpreet

    2016-01-01

    Full Text Available Segmentation is a best method to divide the required region from the medical images. This research is based on segmentation of medical images (MRI, CT scans based on the previous method known as pre-operative and post-recurrence tumor registration (PORTR and proposed method biography based neural clustering (BBNC with genetic processing for tumor segmentation. By using the new technique the extracted part can be view in 3D model and also can get the actual segmented tumor region. This new method will be helpful for diagnostics to find the tumor area as well as pixel difference in segmented part to define the tumor area accurately. While in the previous approach all the parameters have been used likewise, in which the registration method is used to transform the different sets of data into one coordinate system for segmentation of medical images. Registration basically is used to improve the signals to reduce the noise from the images. These techniques are better to find the tumor area from the MRI and CT scans, but after comparing them better results have been obtained in proposed technique. The proposed technique (BBNC reduces the extracted region again into required and actual region of tumor with accuracy of area, time and pixel difference.

  11. The Life and Afterlives of Captain Hedley Vicars: Evangelical Biography and the Crimean War

    Directory of Open Access Journals (Sweden)

    Trev Broughton

    2015-05-01

    Full Text Available This article argues that one of the most influential responses to the Crimean War, and indeed one of the most widely known books of the mid-century, was the work of a woman: the middle-class evangelical Miss Catherine Marsh’s biography of her friend Captain Hedley Vicars. In this book (first published in December 1855, she forged an image of Crimean heroism compatible with Christian piety and good works, and in doing so provided a valued point of connection and identification for many combatant and non-combatant readers. This article explores the ways in which Marsh drew on the resources of memoir and memorial, as well as on the immediacy of war correspondence and the flexibility of print culture, to celebrate a militarized Christianity and a Christian military. A text combining soldierly masculinity with evangelical expressiveness was, however, open to multiple reappropriations and interpretations. As the article goes on to explore, some responses to the 'Memorials of Captain Hedley Vicars of the 97th' were straightforwardly affirmative; others sceptical, ambivalent, or even subversive.

  12. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.

    Science.gov (United States)

    Goyanes, Alvaro; Det-Amornrat, Usanee; Wang, Jie; Basit, Abdul W; Gaisford, Simon

    2016-07-28

    Acne is a multifactorial inflammatory skin disease with high prevalence. In this work, the potential of 3D printing to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrated by two different 3D printing (3DP) technologies: Fused Deposition Modelling (FDM) and stereolithography (SLA). 3D scanning technology was used to obtain a 3D model of a nose adapted to the morphology of an individual. In FDM 3DP, commercially produced Flex EcoPLA™ (FPLA) and polycaprolactone (PCL) filaments were loaded with salicylic acid by hot melt extrusion (HME) (theoretical drug loading - 2% w/w) and used as feedstock material for 3D printing. Drug loading in the FPLA-salicylic acid and PCL-salicylic acid 3D printed patches was 0.4% w/w and 1.2% w/w respectively, indicating significant thermal degradation of drug during HME and 3D printing. Diffusion testing in Franz cells using a synthetic membrane revealed that the drug loaded printed samples released printed as a nose-shape mask by FDM 3DP, but the PCL-salicylic acid filament was not. In the SLA printing process, the drug was dissolved in different mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) (PEG) that were solidified by the action of a laser beam. SLA printing led to 3D printed devices (nose-shape) with higher resolution and higher drug loading (1.9% w/w) than FDM, with no drug degradation. The results of drug diffusion tests revealed that drug diffusion was faster than with the FDM devices, 229 and 291μg/cm(2) within 3h for the two formulations evaluated. In this study, SLA printing was the more appropriate 3D printing technology to manufacture anti-acne devices with salicylic acid. The combination of 3D scanning and 3D printing has the potential to offer solutions to produce personalised drug loaded devices, adapted in shape and size to individual patients.

  13. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  14. Pinhão starch and coat extract as new natural cosmetic ingredients: Topical formulation stability and sensory analysis.

    Science.gov (United States)

    Daudt, Renata Moschini; Back, Patrícia Inês; Cardozo, Nilo Sérgio Medeiros; Marczak, Ligia Damasceno Ferreira; Külkamp-Guerreiro, Irene Clemes

    2015-12-10

    The objective of this study was to use pinhão derivatives, starch and coat extract, as new natural ingredients to develop cosmetic formulations. Two types of formulation, gel and emulgel, and their controls were developed. The formulations were characterized by stability studies using thermal stress. The parameters analyzed were resistance to centrifugation, pH, spreadability, rheology, content of phenolic compounds and antioxidant activity. Sensory analysis was also performed to verify the acceptability of the ingredients to potential consumers. The pH was kept the same after heating/freezing cycles for all formulations, and the formulations showed stability by resistance to centrifugation. The formulations did not induce any skin irritation or cutaneous pH alteration. The pinhão starch addition improved spreadability stability and increased viscosity when compared with control formulations. The pinhão coat extract used in these formulations is a good source of phenolic compounds and antioxidant activity. Moreover, sensory analysis indicates that the emulgel formulation is the best vehicle for adding pinhão starch and pinhão coat extract.

  15. Biography, pandemic time and risk: Pregnant women reflecting on their experiences of the 2009 influenza pandemic.

    Science.gov (United States)

    Lohm, Davina; Flowers, Paul; Stephenson, Niamh; Waller, Emily; Davis, Mark D M

    2014-09-01

    During the 2009 H1N1 pandemic, it was identified that women in the third trimester of pregnancy were particularly at risk of serious respiratory distress. At-risk women were advised to seek vaccination, avoid contact with anyone unwell, maintain hygiene routines and stop smoking. We examine this situation of emergent and intense risk produced at the intersection of individual biography and the historical event of a public health emergency. We examine how pregnant women took account of risk, how they negotiated incomplete and at times contradictory advice and shaped courses of action that assisted them to manage the emerging terrain of pandemic threat. Public health risk management advice was endorsed, although choosing vaccination was fraught. Social distancing, too, was seen as a valuable risk moderation strategy. However, time, and specifically the intersection of individual pregnancy timelines with the pandemic's timeline, was also seen as an important risk management resource. The implications of this mix of sanctioned and temporal risk management practices are discussed.

  16. Women's Health Topics

    Science.gov (United States)

    ... Health Diabetes Healthy Aging Heart Health Mammograms Caregiving Menopause Pregnancy Safe Medication Use Other Topics like cosmetics and nutrition Other Resources womenshealth.gov Federal Citizen Information Center ...

  17. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  18. Expanded abstracts with biographies of the 1991 technical program

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This book covers proceedings of the 61st annual Society of Exploration Geologists meeting. Topics covered include: petroleum and natural gas well logging; field case histories; computers in exploration; physical modeling of reserves; seismic borehole imaging techniques; seismic technique for detecty lithology; and development and production geophysics.

  19. Topic Identification in Discourse

    CERN Document Server

    Chen, K

    1995-01-01

    This paper proposes a corpus-based language model for topic identification. We analyze the association of noun-noun and noun-verb pairs in LOB Corpus. The word association norms are based on three factors: 1) word importance, 2) pair co-occurrence, and 3) distance. They are trained on the paragraph and sentence levels for noun-noun and noun-verb pairs, respectively. Under the topic coherence postulation, the nouns that have the strongest connectivities with the other nouns and verbs in the discourse form the preferred topic set. The collocational semantics then is used to identify the topics from paragraphs and to discuss the topic shift phenomenon among paragraphs.

  20. Time Travel Is Possible: Historical Fiction and Biography, Passport to the Past.

    Science.gov (United States)

    Johnson, Nancy; Ebert, Jane

    Students must learn more than facts if history is to become meaningful for them. They do not relate to names of battles, dates of treaties, or to statistics any more than adults do. They relate to individuals, emotions, and stories that have the ability to arouse their curiosity. The use of historical fiction and biography has the potential of…

  1. Improvising in music: A learning biography study to reveal skill acquisition

    NARCIS (Netherlands)

    Wopereis, Iwan; Van Merriënboer, Jeroen; Kirschner, Paul A.

    2010-01-01

    Wopereis, I. G. J. H., Van Merriënboer, J. J. G., & Kirschner, P. A. (2010). Improvising in music: A learning biography study to reveal skill acquisition. In K. Gomez, L. Lyons, & J. Radinsky (Eds.), Proceedings of the 9th International Conference of the Learning Sciences: Vol. 2 (pp. 419-420). Chic

  2. Meeting Held for the Publication of Biography of Han Xu——Experience of a Diplomat

    Institute of Scientific and Technical Information of China (English)

    OurStaffReporter

    2004-01-01

    Ameeting for the publication of the Book Biography of Han Xu——Experience of a Diplomat was held in the auditorium of the CPAFFC on September 20. Chen Haosu, president of the CPAFFC, and Wang Chengjia, president of the World Affairs Press, co-chaired the meeting. About 60 former colleagues, subordinates,

  3. Meeting Held for the Publication of Biography of Han Xu——Experience of a Diplomat

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>A meeting for the publication of the Book Biography of Han Xu--Experience of a Diplomat was held in the auditorium of the CPAFFC on September 20. Chen Haosu, president of the CPAFFC, and Wang Chengjia, president of the World Affairs Press, co-chaired the meeting. About

  4. Going to School with Madame Curie and Mr. Einstein: Gender Roles in Children's Science Biographies

    Science.gov (United States)

    Owens, Trevor

    2009-01-01

    One of the first places children encounter science and scientists is children's literature. Children's books about science and scientists have, however, received limited scholarly attention. By exploring the history of children's biographies of Marie Curie and Albert Einstein, the two most written about scientist in children's literature, this…

  5. Biographie und Historizität im Wissenschaftsideal : Goethes Weg zur Naturerkenntnis am Beispiel seiner Farbenlehre

    OpenAIRE

    Vedøy, Mons Andreas Finne

    2003-01-01

    Sammendrag: Synopsis Goethe entwarf in seiner Farbenlehre ein naturwissenschaftsmethodisches Ideal, mit dem ein Naturdenken einhergeht, das die Ausrichtung und Methode der modernen Naturwissenschaft, so wie sie von einem seiner wichtigsten Vertreter, Isaac Newton, entwickelt wurde, zu ersetzen versucht. In der vorliegenden Arbeit werden Goethes Motivationen für die Auflehnung gegen das moderne naturwissenschaftliche Denken anhand seiner Biographie untersucht, in der drei Haupthemen ...

  6. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 4.

    Science.gov (United States)

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the fourth volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  7. Biography Today: Profiles of People of Interest to Young Readers. Author Series, Volume 3.

    Science.gov (United States)

    Harris, Laurie Lanzen, Ed.; Abbey, Cherie D., Ed.

    This is the third volume of the "Biography Today Author Series." Each volume contains alphabetically arranged sketches. Each entry provides at least one picture of the individual profiled with additional information about the birth, youth, early memories, education, first jobs, marriage and family, career highlights, memorable experiences,…

  8. "Working Lives": The Use of Auto/Biography in the Development of a Sociological Imagination

    Science.gov (United States)

    Stephenson, Carol; Stirling, John; Wray, David

    2015-01-01

    This article critically evaluates the attempt of the authors to develop a sociological imagination within first-year undergraduate students studying the discipline of sociology at a British university. Through a sociological analysis of biography and autobiography (of both teachers and students), we attempted to create a quality of mind that would…

  9. Orlonia's "Literacy-in-Persons": Expanding Notions of Literacy through Biography and History

    Science.gov (United States)

    Johnson, Amy Suzanne; Cowles, Lauren

    2009-01-01

    Life history methods were used to explore the literate identity of one African American woman, Orlonia, who lives and works in a small rural community in the southeastern United States. Specifically, the authors explore how Orlonia's literate identity is constantly developing throughout her life, taking place in frames of biography and history.…

  10. A Short Biography of Paul A. M. Dirac and Historical Development of Dirac Delta Function

    Science.gov (United States)

    Debnath, Lokenath

    2013-01-01

    This paper deals with a short biography of Paul Dirac, his first celebrated work on quantum mechanics, his first formal systematic use of the Dirac delta function and his famous work on quantum electrodynamics and quantum statistics. Included are his first discovery of the Dirac relativistic wave equation, existence of positron and the intrinsic…

  11. What's in a Research Project: Some Thoughts on the Intersection of History, Social Structure, and Biography.

    Science.gov (United States)

    Popkewitz, Thomas S.

    1988-01-01

    This article focuses on the social formation of research by considering autobiography, biography, and institutions. The discussion covers the relation of U.S. corporate liberalism, Protestant theology, and Jewish identity, and the role of the university in the administration of the state. (TE)

  12. Biography in the Study of Public Administration: Towards a Portrait of a Whitehall Mandarin

    Science.gov (United States)

    Ribbins, Peter; Sherratt, Brian

    2016-01-01

    This paper reports on part of an on-going interview-based study of the eight permanent secretaries who served at the Department for Education from 1976 to 2012. Following a discussion of the relevance of biography to the study of public sector administrators, it presents a portrait of Sir Tim Lankester. Based on his own account and that of…

  13. 清代官修纪传体国史史料价值探微%Discussion on Historical Data Value of Official National History of Biography of Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    崔军伟

    2012-01-01

    Compilation of national history of biography is the essential part of official history in Qing Dynasty. Tremendous texts of national history of biography record the history of nearly three hundred years of Qing Dynasty and save plenty of historical materials. National history of biography is the aggregation of biographies of Qing Dynasty, the summary of institutional system, and the material resources of QINGSHIGAO complied in early Republic of China. It can correct the errors of QINGSHIGAO. The national history of biography is generally true to the historical reality in spite of the inevitable tendency to mythicize the rulers as an official history.%纪传体国史纂修是清代官修史学的重要组成部分。卷帙浩繁的纪传体清国史记录了有清一代近三百年的历史沧桑,为后世保存了大量珍贵的史料。纪传体清国史是清代人物传记之渊薮、典章制度之总结、民国初年所修《清史稿》的重要史源,并可校补《清史稿》舛误。虽然纂修者为维护统治者的形象和利益,不惜曲笔隐瞒历史真相是纪传体清国史之不足,但从整体上看,尊重历史,秉笔直书,仍然是清国史纂修的主流。

  14. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  15. A Survey of Topic Modeling in Text Mining

    Directory of Open Access Journals (Sweden)

    Rubayyi Alghamdi

    2015-01-01

    Full Text Available Topic models provide a convenient way to analyze large of unclassified text. A topic contains a cluster of words that frequently occur together. A topic modeling can connect words with similar meanings and distinguish between uses of words with multiple meanings. This paper provides two categories that can be under the field of topic modeling. First one discusses the area of methods of topic modeling, which has four methods that can be considerable under this category. These methods are Latent semantic analysis (LSA, Probabilistic latent semantic analysis (PLSA, Latent Dirichlet allocation (LDA, and Correlated topic model (CTM. The second category is called topic evolution models, which model topics by considering an important factor time. In the second category, different models are discussed, such as topic over time (TOT, dynamic topic models (DTM, multiscale topic tomography, dynamic topic correlation detection, detecting topic evolution in scientific literature, etc.

  16. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation

    Directory of Open Access Journals (Sweden)

    Sue W. Goldstein, BA, CCRC, IF

    2016-09-01

    Conclusion: Topical alprostadil administered to healthy premenopausal women induced statistically significant, sustained increases in genital temperatures of the vestibule, clitoris, and vulva within 20 minutes compared with OTC lubricant.

  17. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  18. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  19. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

  20. Advanced Topics in Aerodynamics

    DEFF Research Database (Denmark)

    Filippone, Antonino

    1999-01-01

    "Advanced Topics in Aerodynamics" is a comprehensive electronic guide to aerodynamics,computational fluid dynamics, aeronautics, aerospace propulsion systems, design and relatedtechnology. We report data, tables, graphics, sketches,examples, results, photos, technical andscientific literature...

  1. Supplemental topics on voids

    Energy Technology Data Exchange (ETDEWEB)

    Rood, H.J.

    1988-09-01

    Several topics concerning voids are presented, supplementing the report of Rood (1988). The discovery of the Coma supercluster and void and the recognition of the cosmological significance of superclusters and voids are reviewed. Galaxy redshift surveys and redshift surveys for the Abell clusters and very distant objects are discussed. Solar system and extragalactic dynamics are examined. Also, topics for future observational research on voids are recommended. 50 references.

  2. Parent's alcoholism severity and family topic avoidance about alcohol as predictors of perceived stigma among adult children of alcoholics: Implications for emotional and psychological resilience.

    Science.gov (United States)

    Haverfield, Marie C; Theiss, Jennifer A

    2016-01-01

    Alcoholism is a highly stigmatized condition, with both alcohol-dependent individuals and family members of the afflicted experiencing stigmatization. This study examined the severity of a parent's alcoholism and family topic avoidance about alcohol as two factors that are associated with family members' perceptions of stigma. Three dimensions of stigma were considered: discrimination stigma, disclosure stigma, and positive aspect stigma. In addition, this study assessed associations between perceived stigmatization and individuals' experiences of depressive symptoms, self-esteem, and resilience. Adult children of alcoholics (N = 622) were surveyed about family conditions, perceived stigma, and their emotional and psychological well-being. Regression analyses revealed that the severity of a parent's alcoholism predicted all three types of stigma for females, but not for males. In addition, family topic avoidance about alcohol predicted all types of stigma for males and discrimination stigma and positive aspect stigma for females. With few exceptions, the three types of stigma predicted depressive symptoms, self-esteem, and resilience for both male and female adult children of alcoholics. The results are discussed in terms of their implications for promoting a family environment that mitigates stigma and encourages emotional and psychological well-being. In 2012, approximately 3.3 million deaths worldwide were due to the harmful use of alcohol (World Health Organization [WHO], 2014). Individuals who abuse alcohol are susceptible to a variety of negative health outcomes (Rehm et al., 2009) and display inappropriate social behaviors (Klingemann, 2001; Schomerus et al., 2011a). General societal perceptions tend to characterize alcohol-dependent individuals as irresponsible and lacking in self-control (Schomerus et al., 2011b). Research in the United Kingdom found that 54% of the population believes alcohol-dependent individuals are personally to blame for their own

  3. Topical treatment of melasma

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Debabrata

    2009-01-01

    Full Text Available Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  4. TOPICAL TREATMENT OF MELASMA

    Science.gov (United States)

    Bandyopadhyay, Debabrata

    2009-01-01

    Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma. PMID:20101327

  5. Maps on the basis of the Arts & Humanities Citation Index: The journals Leonardo and Art Journal versus "Digital Humanities" as a topic

    CERN Document Server

    Leydesdorff, Loet

    2009-01-01

    The possibilities of using the Arts & Humanities Citation Index (A&HCI) for journal mapping have not been sufficiently recognized because of the absence of a Journal Citations Report (JCR) for this database. A quasi-JCR for the A&HCI (2008) was constructed from the data contained in the Web-of-Science and is used for the evaluation of two journals as examples: Leonardo and Art Journal. The maps on the basis of the aggregated journal-journal citations within this domain can be compared with maps including references to journals in the Science Citation Index and Social Science Citation Index. Art journals are cited by (social) science journals more than by other art journals, but these journals draw upon one another in terms of their own references. This cultural impact in terms of being cited is not found when documents with a topic such as "digital humanities" are analyzed. This community of practice functions more as an intellectual organizer than a journal.

  6. 论《李娃传》的张力%The Tension of Biography of Li Wa

    Institute of Scientific and Technical Information of China (English)

    刘笑雨

    2014-01-01

    At present,there still exist many disputes in the research of Biography of Li Wa,such as Li Wa's characteristics,the theme of the works,the relationship between the ending and theme of the story. This paper starts from the tension theory to conduct the research of BiographyofLiWa. Its unique beauty is narrated from four aspects:the characters,the relationship,the theme,the aesthetic. It is the character, theme and aesthetic closely linked to each other that Biography of Li Wa has received great receptive tension. And that makes the readers have more psychological experience,value judgment and aesthetic enjoyment.%在《李娃传》研究中,学界对诸如李娃的性格特征、作品的主题意蕴、结局与主题的关系等问题尚存在着诸多争议。本文依据张力理论,从人物自身、人物关系、主题思想及审美意蕴四方面分析了《李娃传》独特的张力美。正是由于人物、主题、审美中截然不同的旋律完美地交织在一起,使《李娃传》有了巨大的接受张力,也使读者获得了多层的心理体验、价值判断和审美享受。

  7. Physics 1922 - 1941 including presentation speeches and laureates' biographies

    CERN Document Server

    Zhou, Yong

    1965-01-01

    Physics presents Nobel Lectures on physics from the period of 1922 to 1941. This book is organized into 18 parts encompassing 36 chapters that cover various Nobel physics subjects. The first parts explore the advances in understanding the atom structure, experimental studies of electrons, X-ray spectra of the atomic structure, kinetic energy of free electrons, and discontinuous structure of matter. These topics are followed by discussions on the laws governing the thermionic phenomena, wave nature of electron, light molecular scattering, the development of quantum mechanics, properties of neut

  8. Physics 1942 - 1962 including presentation speeches and laureates' biographies

    CERN Document Server

    Zhou, Yong

    1964-01-01

    Physics 1942 - 1962 presents Nobel Lectures on physics from 1942 to 1962. This book is 20 chapters that cover various Nobel physics subjects. The opening chapters deal with the topics of molecular ray methods, exclusion principle, quantum mechanics, the ionosphere, development of the Meson theory, interaction between high-speed nucleons and atomic nuclei, and the artificial production of fast particles. Other chapters discuss the principle of nuclear induction, research in nuclear magnetism, the discovery of phase contrast, statistical interpretation of quantum mechanics, the hydrogen atom

  9. Topical therapies in hyperhidrosis care.

    Science.gov (United States)

    Pariser, David M; Ballard, Angela

    2014-10-01

    Primary focal hyperhidrosis affects 3% of the US population; about the same number as psoriasis. More than half of these patients have primary focal axillary hyperhidrosis: sweating that is beyond what is anticipated or necessary for thermoregulation. Most topical therapies are based on aluminum salts, which work by a chemical reaction that forms plugs in the eccrine sweat ducts. Topical anticholinergics may also be used. Instruction on proper methods and timing of antiperspirants enhances effect and may be effective alone or in combination with other treatments in patients with hyperhidrosis.

  10. Implicit stage topics

    Directory of Open Access Journals (Sweden)

    Karen Lahousse

    2008-04-01

    Full Text Available Il a souvent été proposé que les éléments spatio-temporels en position initiale de phrase spécifient le cadre de l’événement dénoté par la proposition et ont une interprétation thématique ou topicale. Alors que les topiques spatio-temporels explicites ont souvent été étudiés, Erteschik-Schir (1997, 1999 propose l’idée que les topiques spatio-temporels, ou topiques scéniques (stage topics peuvent aussi être implicites.Dans cet article, nous offrons des arguments en faveur de la notion de topique scénique implicite. Nous montrons qu’un certain nombre de cas d’inversion nominale en français, une configuration syntaxique qui est favorisée par la présence d’un topique scénique explicite, s’expliquent par la présence d’un topique scénique implicite. Le fait que les topiques scéniques implicites interagissent avec la structure syntaxique de la même façon que les topiques scéniques explicites constitue un argument empirique en faveur de leur existence.It has often been proposed that sentence-initial spatio-temporal elements specify the frame in which the whole proposition takes place and are topical (i.e. thematic. Whereas considerable attention has been paid to explicit spatio-temporal topics, Erteschik-Shir (1997, 1999 argues that spatio-temporal topics, or stage topics, can also be implicit.In this article we provide evidence in favour of the notion of implicit stage topic. We show that a certain number of nominal inversion cases in French, a syntactic configuration which is triggered by the presence of an explicit stage topic, are explained by the presence of an implicit stage topic. The fact that implicit stage topics interact with syntactic structure the same way explicit stage topics do constitutes a strong empirical argument in favour of their existence.

  11. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  12. Topical therapy of molluscum contagiosum as a comparative therapeutic study using 15% phenol in lactic acid, 5% tincture iodine and pricking alone

    Directory of Open Access Journals (Sweden)

    Khalifa E. Sharquie

    2016-07-01

    dermatitis, allergic bronchitis were found in 17 (22.7% patients. After 3 weeks of treatment, the response rates were as follows: Group 1: 23/25 (92% patients cured completely, 2 (8% patients failed to achieve complete clearing, p-value was highly significant 0.05. Scars were not reported in any group. Conclusion: Pricking molluscum contagiosum lesions by orange stick alone is safe, cost effective, highly effective and stimulating mode of therapy. Still topical 15% phenol in lactic acid and 5% tincture iodine are new and effective modes of treatment.

  13. Topics in statistical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references.

  14. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  15. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    Science.gov (United States)

    Harris, Reviewed By Harold H.

    1999-11-01

    until 1904, when he accepted a position that would not be considered a shrewd career move: Superintendent of Weights and Measures in Manila, Philippines! He was there only one year, but it was apparently a productive time, both in a minimally equipped laboratory and with the possible nascence of some of his ideas about bonding. In 1905, Lewis accepted a staff position at MIT, under A. A. Noyes, where he remained until 1912. At MIT, he continued his experimental work on thermodynamic systems and the development of modern thermodynamics, following the lead of J. W. Gibbs, whose work was being largely ignored by other chemists. As Noyes moved increasingly into administrative responsibilities, Lewis took over more and more of the supervision of scientific work in the laboratory. It was the capable job that he did for Noyes that led to his being offered a Professorship and Chair of the College of Chemistry at the University of California, Berkeley. The same spirit of adventure that took Lewis to Manila may be what led to his moving to scientifically backward California. In 1912, there was no serious science going on the Left Coast, and Berkeley was isolated from the nearest civilization (Chicago) by days of travel. Lewis initiated the expansion of great science westward, not only to Berkeley, but also to Caltech (in those days Throop Institute), UCLA, and Stanford. By dint of his contributions to thermodynamics and bonding theory (suggesting that electrons bond in pairs, long before there was quantum mechanical justification for such a strange idea), and his organizational and leadership talents, he turned the Berkeley Chemistry Department from a nonentity into one of the finest anywhere. Later in his career, he contributed to the understanding of the role of isotopes in chemistry and physics. This biography includes a useful listing of Lewis's 168 scientific publications. In an age when many renowned scientists have multiples of this number, it is perhaps good to be

  16. Academic Biography in the Context of the Anti-Formalist Campaign of the 1930s

    Directory of Open Access Journals (Sweden)

    Yelena N. Penskaya

    2014-07-01

    Full Text Available The paper is focused around two biographical themes. Theme one is history of demolishing Leningrad school of dramatic theory developed in the State Institute of History of Art (GIII in the 1920s. In 1931, the GIII was closed by a Sovnarkom resolution and transformed into Len- ingrad division of the State Academy of Art Studies (LOGAIS established by the same resolu- tion. Theme two is description of the ‘academic traumatism’, traumatic behavior and its bio- graphical effects caused by destruction of a whole scientific trend during the anti-formalism campaign of the early 1930s. Based on archival documents (from the Russian State Archive of Literature and Art, shorthand notes and reports on discussions of the 1930s, we analyze behav- ioral tactics of initiators, participants and victims of the longstanding stigmatization and catalog absolutory, denunciative and repentant narratives. In particular, this paper analyzes the un- published letter to the editors of Rabochiy i Teatr journal written by Alexander Slonimsky, one of the key players in development and obliteration of dramatic theory associated primarily with Alexei Gvozdev’s group and with transformation and dissolution of the leading humanities in- stitutes. The text of the letter appears to be engrained in the complicated mosaic of measures aimed to discredit Meyerhold’s theater practice and Gvozdev as the leader of the scientific school. Deliberate misinterpretation and corruption of self-descriptions along with reconstruc- tion of biographies are some of the most crucial factors that affected reception of cultural pro- jects and their creators in the 1930s and later.

  17. The theorist Guillermus de Podio: foundations for the construction of a biography.

    Directory of Open Access Journals (Sweden)

    Villanueva Serrano, Francesc

    2010-12-01

    Full Text Available Two works of music theory from the endings of the 15th Century with the name of author Guillermus de Podio are preserved: the printed Ars musicorum (València, Hagenbach and Hutz, 1495 and the manuscript Enchiridion de principiis musice discipline contra negantes illa et destruentes. Despite the great influence that this musician exerted on Spanish theorists of the 16th Century, there are only few commonly accepted data about his biography. This article pretends to offer solid foundations to build his biography. In first place, verified from speculated data in the historiography of the musician will be distinguished. Finally, new documents will clarify his identity and will reveal his work as master of chant in the catedral of Valencia.Bajo el nombre de autor de Guillermus de Podio se conservan dos obras de teoría musical de finales del siglo XV: la impresa Ars musicorum (Valencia, Hagenbach y Hutz, 1495 y el manuscrito Enchiridion de principiis musice discipline contra negantes illa et destruentes. A pesar de la gran influencia que este músico ejerció sobre los teóricos españoles del siglo XVI, son mínimos los datos biográficos generalmente aceptados por la comunidad investigadora. El presente artículo pretende ofrecer unos cimientos sólidos sobre los cuales poder construir su biografía. Con esta finalidad, se distinguen primeramente los datos contrastados de los que forman parte de la especulación en la historiografía del músico. Finalmente se aportan nuevos documentos que resuelven las dudas sobre su identidad y desvelan su magisterio en la catedral de Valencia. [ct] Sota el nom d’autor de Guillermus de Podio es conserven dues obres de teoria musical de finals del segle XV: l’impresa Ars musicorum (València, Hagenbach i Hutz, 1495 i el manuscrit Enchiridion de principiis musice discipline contra negantes illa et destruentes. Malgrat la gran influència que aquest músic va exercir sobre els teòrics espanyols del segle XVI

  18. The Health Curriculum: 500 Topics.

    Science.gov (United States)

    Byrd, Oliver E.

    2001-01-01

    This 1958 paper divides 500 health topics into 20 categories: health as a social accomplishment/social problem; nutrition; physical fitness; mental health and disease; heredity/eugenics; infection/immunity; chronic and degenerative disease; substance abuse; skin care; vision, hearing, and speech; dental health; safety; physical environment; health…

  19. Researching Distressing Topics

    Directory of Open Access Journals (Sweden)

    Sharon Jackson

    2013-05-01

    Full Text Available Qualitative researchers who explore sensitive topics may expose themselves to emotional distress. Consequently, researchers are often faced with the challenge of maintaining emotional equilibrium during the research process. However, discussion on the management of difficult emotions has occupied a peripheral place within accounts of research practice. With rare exceptions, the focus of published accounts is concentrated on the analysis of the emotional phenomena that emerge during the collection of primary research data. Hence, there is a comparative absence of a dialogue around the emotional dimensions of working with secondary data sources. This article highlights some of the complex ways in which emotions enter the research process during secondary analysis, and the ways in which we engaged with and managed emotional states such as anger, sadness, and horror. The concepts of emotional labor and emotional reflexivity are used to consider the ways in which we “worked with” and “worked on” emotion. In doing so, we draw on our collective experiences of working on two collaborative projects with ChildLine Scotland in which a secondary analysis was conducted on children’s narratives of distress, worry, abuse, and neglect.

  20. Novel-Biography in the Context of Modernist Aesthetics (Based on V. Woolf Novel “Orlando”)

    OpenAIRE

    Kunytska, Iryna

    2016-01-01

    Based on the research of novel “Orlando” by Virginia Woolf the thesis proved that novel-biography is the kind of modernistic novel. The classic form of biographical novel in the system of modernistic aesthetics gained other function substantially. Modernism created a foundation so that a writer could use someone’s biography on their way to self-knowledge. The main idea was the internal harmony of creative individuals. Before the documentary became fiction and modernist there should have been ...

  1. “Such a plain and uninteresting man…”. On the biography of Bolesław Leśmian

    Directory of Open Access Journals (Sweden)

    Ewa Rajewska

    2009-01-01

    Full Text Available The article discusses five biographies of the poet that have been published in the past few years. A highly complex and contradicting figure of Leśmian, a great poet and unsuccessful notary public, a provincial from the capital Warsaw, a misanthrope with busy social life, still arouses interests among the public – the more so that his first biography written by Łopuszański and entitled Leśmian was published as late as 2000. Łopuszański, who has been working on Leśmian for twenty years, has published the results of his biographical investigations in his two subsequent books: Zofia i Bolesław Leśmianowie (2005 and Bolesław Leśmian. Marzyciel nad przepaścią (2006. In turn, Leśmian. Encyklopedia (2001 by Rymkiewicz is a different book being a ”personal” encyclopaedia, a somewhat patchy biography that focuses on arbitrarily selected entries chosen by its author, whereas Leśmian, Leśmian… Wspomnienia o Bolesławie Leśmianie zebrane przez Adama Wiesława Kulika (2008 is a collection of memoirs, a record of conversations that the author had with the inhabitants of Hrubieszów and Zamość who knew Leśmian personally in the 1920s and the 1930s – his colleagues at the Bar, workers of the notary’s office, his acquaintances, neighbours and friends of his daughters.

  2. Screening Jane. When History, Biography and Fiction create a Cinematic Life.

    Directory of Open Access Journals (Sweden)

    Roberta Grandi

    2015-07-01

    Full Text Available This paper analyzes the interesting technique of adaptation of the film Becoming Jane, a biopic on the life of Jane Austen, released in 2007. Loosely based on Jon Spence's biography Becoming Jane Austen, the film faces the problem of the scarcity of information on Jane Austen's life through a technique that, if not original nor always satisfying, is nevertheless worth being studied. By recurring to the character descriptions and the anecdotes narrated in the novels, the film (and Spence's book too "fills in the blanks" in Austen's life by adding touches of romance with questionable historical accuracy and fictionalizes the writer's biography in order to adapt it to the stereotype of modern romantic film heroines.

  3. Usage-Oriented Topic Maps Building Approach

    Science.gov (United States)

    Ellouze, Nebrasse; Lammari, Nadira; Métais, Elisabeth; Ben Ahmed, Mohamed

    In this paper, we present a collaborative and incremental construction approach of multilingual Topic Maps based on enrichment and merging techniques. In recent years, several Topic Map building approaches have been proposed endowed with different characteristics. Generally, they are dedicated to particular data types like text, semi-structured data, relational data, etc. We note also that most of these approaches take as input monolingual documents to build the Topic Map. The problem is that the large majority of resources available today are written in various languages, and these resources could be relevant even to non-native speakers. Thus, our work is driven towards a collaborative and incremental method for Topic Map construction from textual documents available in different languages. To enrich the Topic Map, we take as input a domain thesaurus and we propose also to explore the Topic Map usage which means available potential questions related to the source documents.

  4. 从《伯夷列传》到《司马穰苴列传》看《史记》列传文体前期的发展%The Early Stage Style Development of the Biographies of ShiJi in the Perspectives of Biography of BoYi and Biographies of Simarangju

    Institute of Scientific and Technical Information of China (English)

    杨昊鸥

    2015-01-01

    《史记》列传文体形态丰富多变,一直受到历代《史记》评点家、研究者的关注而尚未开展深入的研究。《史记》列传的前四篇(《伯夷列传》、《管晏列传》、《老子韩非列传》、《司马穰苴列传》)实际上包含着《史记》列传在文体上早期的形态变化,这种变化呈现出引用和评论手段的缩减,以及叙事成分的不断加重的趋势,也即意味着《史记》列传文体由传统经传转向为新型史传的重要转变。%The literary form style of biography of ShiJi is complex and varied. Importance had been always attached to this problem by researchers in past dynasties, yet profound study had not been done. The first four biographies in ShiJi, including Biography of BoYi, Biography of GuanZi and Yanzi, Biography of LaoZi and HanFei, Biography of Simarangju,contained the change of style about the early Biography of ShiJi. This change presented the trend that quote and comment reduced while narration increased at the same time, that there was a great change in the literary form style of Biography of ShiJi into ShiZhuan Sytle from JingZhuan Sytle.

  5. Die Verflechtung von Biographie und musikalischer Diegese in Clint Eastwoods BIRD (USA 1988)

    OpenAIRE

    Strank, Willem

    2010-01-01

    In den 1980er Jahren wurde die Tradition des Musiker-Biopics auf dem Gebiet des Jazzmusikers durch einige wesentliche Exempel wiederbelebt. Eines der wichtigsten Beispiele war hierbei mit Sicherheit der wenig später entstandene Film BIRD von Clint Eastwood aus dem Jahre 1988. Der Versuch einer filmischen Biographie von Charlie Parker muss hierbei von Vornherein problematisch erscheinen: Erstens ist es kaum möglich, sein Leben wie im traditionellen Hollywood-Biopic mit einem verklärenden Happy...

  6. Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Simon Mackie

    2010-01-01

    Conclusion. Trans-nasal endoscopic resection and topical 5-Fluorouracil could potentially offer an acceptable alternative treatment to the standard of cranio-facial resection. This should be investigated in trials with a longer followup period than this paper in order to directly compare the two treatment modalities.

  7. Severe photosensitivity reaction induced by topical diclofenac

    OpenAIRE

    Akat, Pramod B.

    2013-01-01

    Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

  8. Severe photosensitivity reaction induced by topical diclofenac

    Directory of Open Access Journals (Sweden)

    Pramod B Akat

    2013-01-01

    Full Text Available Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

  9. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  10. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  11. Contrastive topics decomposed

    Directory of Open Access Journals (Sweden)

    Michael Wagner

    2012-12-01

    Full Text Available The analysis of contrastive topics introduced in Büring 1997b and further developed in Büring 2003 relies on distinguishing two types of constituents that introduce alternatives: the sentence focus, which is marked by a FOC feature, and the contrastive topic, which is marked by a CT feature. A non-compositional rule of interpretation that refers to these features is used to derive a topic semantic value, a nested set of sets of propositions. This paper presents evidence for a correlation between the restrictive syntax of nested focus operators and the syntax of contrastive topics, a correlation which is unexpected under this analysis. A compositional analysis is proposed that only makes use of the flatter focus semantic values introduced by focus operators. The analysis aims at integrating insights from the original analysis while at the same time capturing the observed syntactic restrictions. http://dx.doi.org/10.3765/sp.5.8 BibTeX info

  12. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...

  13. Topics for Mathematics Clubs.

    Science.gov (United States)

    Dalton, LeRoy C., Ed.; Snyder, Henry D., Ed.

    The ten chapters in this booklet cover topics not ordinarily discussed in the classroom: Fibonacci sequences, projective geometry, groups, infinity and transfinite numbers, Pascal's Triangle, topology, experiments with natural numbers, non-Euclidean geometries, Boolean algebras, and the imaginary and the infinite in geometry. Each chapter is…

  14. Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407.

    Science.gov (United States)

    Pawar, Jaywant; Narkhede, Rajkiran; Amin, Purnima; Tawde, Vaishali

    2017-01-20

    The aim of the present context was to develop and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor® P407 and Kollisolv® PEG400 as a gel base. Diclofenac sodium was used as a model drug. The HME parameters such as feeding rate, screw speed, and barrel temperature were crucial for the semisolid product development, and were optimized after preliminary trials. For the processing of the gel formulation by HME, a modified screw design was used to obtain a uniform product. The obtained product was evaluated for physicochemical characterization such as differential scanning calorimetry (DSC), X-ray diffraction (XRD), pH measurement, rheology, surface tension, and texture profile analysis. Moreover, it was analyzed for general appearance, spreadibility, surface morphology, and drug content. The optimized gel formulation showed homogeneity and transparent film when applied on a glass slide under microscope, pH was 7.02 and uniform drug content of 100.04 ± 2.74 (SD = 3). The DSC and XRD analysis of the HME gel formulation showed complete melting of crystalline API into an amorphous form. The Kolliphor® P407 and Kollisolv® PEG400 formed excellent gel formulation using HME with consistent viscoelastic properties of the product. An improved drug release was found for the HME gel, which showed a 100% drug release than that of a marketed product which showed only 88% of drug release at the end of 12 h. The Flux value of the HME gel was 106 than that of a marketed formulation, which showed only about 60 value, inferring a significant difference (P < 0.05) at the end of 1 h. This study demonstrates a novel application of the hot melt extrusion

  15. The pharmacology of topical analgesics.

    Science.gov (United States)

    Barkin, Robert L

    2013-07-01

    systemic circulation, topically applied analgesics are associated with application-site reactions in patients, such as dryness, erythema, burning, and discoloration. Furthermore, some adverse events that have been observed in patients may be suggestive of some degree of systemic exposure. This article reviews the mechanisms of action, pharmacokinetics, and tolerability of topical treatments for the management of patient pain.

  16. The treatment of rosacea with topical ivermectin.

    Science.gov (United States)

    Ali, S T; Alinia, H; Feldman, S R

    2015-04-01

    The treatment of rosacea is challenging because several pathophysiologic processes may be involved, including neurovascular dysregulation and alterations in innate immune status. Demodex mites may play a role in the latter mechanism. Topical ivermectin is a new therapeutic modality which demonstrates antiparasitic and anti-inflammatory properties. This article reviews published evidence related to the efficacy and safety of topical ivermectin. PubMed was utilized to search for key words "topical ivermectin", "ivermectin cream" and "rosacea". Three clinical trials were found that studied topical ivermectin as a treatment option for rosacea. Ivermectin was effective, safe and well tolerated.

  17. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1979-01-01

    Probabilistic Analysis and Related Topics, Volume 2 focuses on the integrability, continuity, and differentiability of random functions, as well as functional analysis, measure theory, operator theory, and numerical analysis.The selection first offers information on the optimal control of stochastic systems and Gleason measures. Discussions focus on convergence of Gleason measures, random Gleason measures, orthogonally scattered Gleason measures, existence of optimal controls without feedback, random necessary conditions, and Gleason measures in tensor products. The text then elaborates on an

  18. Church Attendance as a Predictor of Number of Sexual Health Topics Discussed Among High-Risk HIV-Negative Black Women.

    Science.gov (United States)

    Williams, Terrinieka T; Pichon, Latrice C; Davey-Rothwell, Melissa; Latkin, Carl A

    2016-02-01

    Research suggests that sexual health communication is associated with safer sex practices. In this study, we examined the relationship between church attendance and sexual health topics discussed with both friends and sexual partners among a sample of urban Black women. Participants were 434 HIV-negative Black women who were at high risk for contracting HIV through heterosexual sex. They were recruited from Baltimore, Maryland using a network-based sampling approach. Data were collected through face-to-face interviews and Audio-Computer-Assisted Self-Interviews. Fifty-four percent of the participants attended church once a month or more (regular attendees). Multivariate logistic regression analyses revealed that regular church attendance among high-risk HIV-negative Black women was a significant predictor of the number of sexual health topics discussed with both friends (AOR = 1.85, p = .003) and sexual partners (AOR = 1.68, p = .014). Future efforts to reduce HIV incidence among high-risk Black women may benefit from partnerships with churches that equip faith leaders and congregants with the tools to discuss sexual health topics with both their sexual partners and friends.

  19. Novel Topic Authorship Attribution

    Science.gov (United States)

    2011-03-01

    cross-validation, genre shift, vector projection, singular value decomposition, principal component analysis Unclassified Unclassified Unclassified...by eight students. Each student wrote a total of 24 documents in three different genres about three different topics. They found that compensating for...Baayen, H. Halteren, A. Neijt, and F. Tweedie, “Outside the cave of shadows: Using syntactic annotation to enhance authorship attribution,” Literary

  20. Prioritizing dermatoses: rationally selecting guideline topics

    NARCIS (Netherlands)

    Borgonjen, R.J.; Everdingen, J.J. van; Kerkhof, P.C.M. van de; Spuls, P.I.

    2015-01-01

    BACKGROUND: Clinical practice guideline (CPG) development starts with selecting appropriate topics, as resources to develop a guideline are limited. However, a standardized method for topic selection is commonly missing and the way different criteria are used to prioritize is not clear. OBJECTIVES:

  1. Psoriasis: improving adherence to topical therapy.

    NARCIS (Netherlands)

    Feldman, S.R.; Horn, E.J.; Balkrishnan, R.; Basra, M.K.; Finlay, A.Y.; McCoy, D.; Menter, A.; Kerkhof, P.C.M. van de

    2008-01-01

    Topical therapy has an important role in psoriasis treatment. It is efficacious and has a favorable safety profile as demonstrated in clinical trials. However, poor treatment outcomes from topical therapy regimens likely result from poor adherence and ineffective use of the medication. The Internati

  2. 《潜研堂文集》学者传记与清代学术史的书写%Scholars’Biographies in Qianyan Tang Collected Works and the Writing of Academic History of the Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    冯坤

    2014-01-01

    钱大昕《潜研堂文集》卷三十八、三十九的一组学者传记,历来被简单的作为《汉学师承记》的原始材料看待,导致其中作者记录当代学术史的意识没有受到相应的重视。从这组传记的传主选择,到它们的写作方式,无不体现着作者的史家眼光与精心选择。而我们熟悉的《汉学师承记》,其中的一些问题,如人物选取、写作体例,也都可以追溯至这组传记之中。%The series of scholars’biographies in Volume 38 and 39 of Qian Daxin’s Qianyan Tang Collected Works have been viewed simply as a raw material of Jiang Fan’s Biographies ofHan Learning Scholars,while the author’s writing of academic history hasn’t received the due attention.Both the choice of scholars and the way of writing reflect the author's historian vision and elaborate selection.And some questions in Biographies of Han Learning Scholars,such as the character selection,writing style,can also be traced back to these biographies.

  3. Hot topics in functional neuroradiology.

    Science.gov (United States)

    Faro, S H; Mohamed, F B; Helpern, J A; Jensen, J H; Thulborn, K R; Atkinson, I C; Sair, H I; Mikulis, D J

    2013-12-01

    Functional neuroradiology represents a relatively new and ever-growing subspecialty in the field of neuroradiology. Neuroradiology has evolved beyond anatomy and basic tissue signal characteristics and strives to understand the underlying physiologic processes of central nervous system disease. The American Society of Functional Neuroradiology sponsors a yearly educational and scientific meeting, and the educational committee was asked to suggest a few cutting-edge functional neuroradiology techniques (hot topics). The following is a review of several of these topics and includes "Diffusion Tensor Imaging of the Pediatric Spinal Cord"; "Diffusional Kurtosis Imaging"; "From Standardization to Quantification: Beyond Biomarkers toward Bioscales as Neuro MR Imaging Surrogates of Clinical End Points"; Resting-State Functional MR Imaging"; and "Current Use of Cerebrovascular Reserve Imaging."

  4. Armorican arrowhead biographies: Production and function of an Early Bronze Age prestige good from Brittany (France

    Directory of Open Access Journals (Sweden)

    Clément Nicolas

    2014-09-01

    , etc.. According to these obvious facts, they symbolize the power of the elites. The genesis of Armorican arrowheads are in all likelihood explained by a climate of increasing social competition, which express itself in Brittany by an individualization of burial rites, a development of metalworking and a reorganization of territories.In this article, we will stress on raw materials selection, technology and know-how, as well as use-wear analyses. All these approaches will help us to trace the biographies of the Armorican arrowheads.

  5. A Textual Research of the Biography of the Loyal and Righteous Persons of Song History%《宋史·忠义传》考辨二则

    Institute of Scientific and Technical Information of China (English)

    孙廷林; 王元林

    2015-01-01

    The eight biographies of Zhu Zhao,Sun Yi,and Zhang Zhongfu,etc. in "the Biography of the Loyal and Righteous Persons of Song History" originate from Zhu Bian's "the Memorial to the Throne of Zhu Zhao Loyalty". Since much of "the Memorial" comes from rumors,there are quite many mistakes about the loyalties in "the Memorial". Therefore,the Zhang Zhongfu in "Loyalty Three" of Vol.448 is actually the same person as the Zhang Hongfu in "Loyalty Seven" of Vol.452,and the right should be Zhang Hongfu.%《宋史·忠义传》中朱昭、孙益、张忠辅等八人的史源是朱弁《上朱昭等忠义奏疏》.鉴于朱弁多得自传闻,故其《奏疏》记述忠义之士颇有讹误.其中《宋史》卷四四八《忠义三》之张忠辅,与同书卷四五二《忠义七·李翼传》之张洪辅,确为一人,当以张洪辅为正.

  6. Correction and Supplement on the Biography of Wang Boyan in Song History%《宋史·汪伯彦传》补正

    Institute of Scientific and Technical Information of China (English)

    刘云军

    2011-01-01

    汪伯彦(1069—1141),祁门(今属安徽)人。北宋徽宗朝进士。南宋高宗朝历任知枢密院事、右仆射兼中书侍郎等。以宋代史料为主,对《宋史·汪伯彦传》进行补正,补正范围主要是对其记载简略之处的史实补充以及与《宋史》本传记载有歧义之处的史料对比。%Wang Boyan(1069—1141) was from QiMen(now part of Anhui) who passed the examination in HuiZong Emperor.During Southern Song Dynasty,GaoZong Emperor,he served as a Manager of the Bureau Military,the Grand Councilor and so on.Based on the historical data of Song Dynasty mainly,the author of this paper makes correction and supplement on the Biography of Wang Boyan in Song History,mainly gives supplement to the brief records of the historical facts and makes the comparison of the different interpretations between the historical facts in the Biography of Wang Boyan in Song History and that in Song History itself.

  7. 浅议《李斯列传》的叙事特点%The Narrative Characteristics of Biography of Li Si

    Institute of Scientific and Technical Information of China (English)

    凌璐丝

    2016-01-01

    In Biography of Li Si, Sima Qian used a variety of narrative techniques and skills, viewing the situation of rats to see big things through small ones, to indicate his philosophy of life. “Five times of complaints and six times of persuasions” as the nar⁃rative joints, the development of Li’ s life is the rise and fall of the Qin Dynasty. Sima Qian used the reasonable narrative structure and proper details in Biography of Li Si, which makes the dialogues very vivid. Hence, the history of the Qin Dynasty stands vividly to reveal on the paper, so that future generations can be used for reference and alert.%在《李斯列传》中,司马迁运用了多种叙事特点和技巧,以观鼠之境遇来以小见大,预示李斯的人生哲学;又以“五叹六说”为叙事关节点;而李斯的人生发展实为秦朝的兴衰史;司马迁叙事一向结构合理,详略得当,《李斯列传》中的人物对话更使叙事生动,历史跃然纸上,使后世得以借鉴和警醒。

  8. Correlated Topic Model for Web Services Ranking

    Directory of Open Access Journals (Sweden)

    Mustapha AZNAG

    2013-07-01

    Full Text Available With the increasing number of published Web services providing similar functionalities, it’s very tedious for a service consumer to make decision to select the appropriate one according to her/his needs. In this paper, we explore several probabilistic topic models: Probabilistic Latent Semantic Analysis (PLSA, Latent Dirichlet Allocation (LDA and Correlated Topic Model (CTM to extract latent factors from web service descriptions. In our approach, topic models are used as efficient dimension reduction techniques, which are able to capture semantic relationships between word-topic and topic-service interpreted in terms of probability distributions. To address the limitation of keywords-based queries, we represent web service description as a vector space and we introduce a new approach for discovering and ranking web services using latent factors. In our experiment, we evaluated our Service Discovery and Ranking approach by calculating the precision (P@n and normalized discounted cumulative gain (NDCGn.

  9. Large scale topic modeling made practical

    DEFF Research Database (Denmark)

    Wahlgreen, Bjarne Ørum; Hansen, Lars Kai

    2011-01-01

    Topic models are of broad interest. They can be used for query expansion and result structuring in information retrieval and as an important component in services such as recommender systems and user adaptive advertising. In large scale applications both the size of the database (number of docume......Topic models are of broad interest. They can be used for query expansion and result structuring in information retrieval and as an important component in services such as recommender systems and user adaptive advertising. In large scale applications both the size of the database (number...... topics at par with a much larger case specific vocabulary....

  10. Topical diclofenac does not affect the antiplatelet properties of aspirin as compared to the intermediate effects of oral diclofenac: A prospective, randomized, complete crossover study.

    Science.gov (United States)

    Rowcliffe, M; Nezami, B; Westphal, E S; Rainka, M; Janda, M; Bates, V; Gengo, F

    2016-04-01

    Nonsteroidal anti-inflammatory drugs (NSAIDs) adversely interact with aspirin, diminishing its antiplatelet effect and potentially placing patients at an increased risk for recurrent thrombotic events. This crossover study aimed to determine whether the topical NSAID diclofenac epolamine 1.3% patch or oral diclofenac 50 mg interfered with the antiplatelet effects of aspirin 325 mg. Twelve healthy men and women aged 18-50 were included. Participants were randomized into 5 treatment arms: aspirin, diclofenac potassium 50 mg, diclofenac patch, diclofenac potassium plus ASA 325 mg, and diclofenac patch plus aspirin. Platelet responsiveness was determined using whole-blood impedance aggregation (WBA) to collagen 1 μg/mL and arachidonic acid (AA) 0.5 mM and was sampled every 2 hours. No significant difference in platelet function was observed following the diclofenac patch and aspirin vs aspirin alone. Oral diclofenac produced a mixed effect with significant reduction in platelet inhibition at hour 2 and hour 8 following aspirin administration. Topical diclofenac does not significantly interfere with the antiplatelet effects of aspirin and may be a safer alternative to the oral formulation.

  11. Soviet “Life Canon” in scientist’s biography and problem of its overcoming

    Directory of Open Access Journals (Sweden)

    Khazagerov Georgii Georgievich

    2015-03-01

    Full Text Available This article is dedicated to one of the fragments of modern textual culture, namely the presentation of the image of the scientist, usually presented in the book, devoted to anniversaries. Often it is the memories of students. Scientific pathos of the article is due to the fact that these memories do not always create a life image of the scientist, not realizing his appointment. Often different publications not only smooth personal traits of individuals, but also smooth individual features of the style of the authors and individual differences of their texts. The article identifies the causes of these phenomena. One of them is blind, non-functional copy of topos characteristic of Soviet biographies. It is, for example, a topos of poverty and democratic origin of the scientist who during the Soviet biographies was intended to carry out agitation and didactic function. Combining topos with biographical frame results in a maximum leveling in the representation of a person. Thus it appears what the article calls “Soviet life canon.” Another reason for the smoothing of individual style and create a speculative form of teaching is the penetration in the biographical genre of officialese expressing indifferent attitude to people. Concerning modern biographies of scientists officialese involves business style, that serves genres of reviews, i.e. all that is related to business decision-making relating to the work of the scientist. The article pointed out ways to overcome these negative trends in modern publications related to the demand for intimization category, which primarily should be shown in the plot structure of the narration.

  12. [New in the biography of a military doctor A. G. Peredelsky].

    Science.gov (United States)

    Savinova, T N

    2014-11-01

    The history of activity of the Orenburg department of the Kazan society of adherents of military and sanitary knowledge is shown in article. The department existed in 1912-1914 and united officers and medical officers of the Orenburg garrison and military educational institutions. Members of Department tried to resolve the vital issues of a sanitary condition of Totsky military camp, regiments of the Orenburg military of the garrison. The department managed to publish two releases of the works. On these materials we can judge its activity. In article new data from A.G.Peredelsky's biography (1876-1940) in the period of his life in Orenburg are reported.

  13. Fishy Hearing: A Short Biography of Arthur N. Popper, PhD.

    Science.gov (United States)

    Coffin, Allison B

    2016-01-01

    Biologist Dr. Arthur Popper's career spans decades, from his early work on comparative inner ear morphology in fishes to his recent interest in how underwater noise impacts aquatic vertebrates. Along the way Dr. Popper's research subjects span at least 19 vertebrate taxa, from lamprey to lungfish to humans, and he's had a profound influence in the field of fish bioacoustics. This brief biography describes some of Dr. Popper's many contributions to fish hearing research and highlights both some of his major discoveries and some of the biological mysteries he has yet to solve.

  14. Serendipity: a personal tale of two biographies, William Richard Gowers (1845-1915) and his son Ernest (1880-1966).

    Science.gov (United States)

    Scott, Ann

    2015-08-01

    Between 2004 and 2012, the author wrote two biographies, the first of 20th century civil servant Ernest Gowers and the second of his father the Victorian neurologist William Richard Gowers. This article describes the author's experience conducting the research for two biographies at a time when the research tools available were rapidly shifting from paper-based to digital records. Technological aids have made the preliminary research of historians easier, but they have not taken the place of hard copy archive-based research. While the paper will focus primarily on the biography of William Richard Gowers, the author describes the research methods she employed to help reveal the personalities, strengths and weaknesses of both men, each of whom left his own intellectual legacy.

  15. Computer Cache. Celebrating Women: History, Biographies, and Museums

    Science.gov (United States)

    Byerly, Greg; Brodie, Carolyn S.

    2005-01-01

    This column shares a host of websites that feature resources about women in history, famous women, and women's contributions. These websites can be used all year long, as well as in conjunction with Women's History Month in March,

  16. Hot topics for leadership development.

    Science.gov (United States)

    Bleich, Michael R

    2015-02-01

    Three areas stand out from a health systems perspective that should be on the development agenda for all leaders. These topics include population health, predictive analytics, and supply chain management. Together, these topics address access, quality, and cost management.

  17. Life History Approach: Biographies and psycho-societal Interpretation

    DEFF Research Database (Denmark)

    Olesen, Henning Salling

    2016-01-01

    -societal approach indicates the ambition of attacking the dichotomy of the social and the psychic, both in the interpretation procedure and in some main theoretical understandings of language, body and mind. My article will present the reflections on the use of life history based methodology in learning...... in intended as well as unintended learning, in formal education as well as in everyday life. Life histories represent lived lives past, present and anticipated future. As such they are interpretations of individuals’ experiences of the way in which societal dynamics take place in the individual body and mind......, either by the individual him/herself or by another biographer. The Life History approach was developing from interpreting autobiographical and later certain other forms of language interactive material as moments of life history, i.e. it is basically a hermeneutic approach. Talking about a psycho...

  18. Topics in orbit equivalence

    CERN Document Server

    Kechris, Alexander S

    2004-01-01

    This volume provides a self-contained introduction to some topics in orbit equivalence theory, a branch of ergodic theory. The first two chapters focus on hyperfiniteness and amenability. Included here are proofs of Dye's theorem that probability measure-preserving, ergodic actions of the integers are orbit equivalent and of the theorem of Connes-Feldman-Weiss identifying amenability and hyperfiniteness for non-singular equivalence relations. The presentation here is often influenced by descriptive set theory, and Borel and generic analogs of various results are discussed. The final chapter is a detailed account of Gaboriau's recent results on the theory of costs for equivalence relations and groups and its applications to proving rigidity theorems for actions of free groups.

  19. Biography of Are Tsirk (1937-2015: Flintknapper and scholar

    Directory of Open Access Journals (Sweden)

    Steve Adams

    2015-03-01

    Full Text Available Are Tsirk was as much a scholar as he was a flintknapper. These disciplines were intertwined and expressed in his experimental research, by way of his exploration of fractography, and his replication of stone tools which spanned the archaeological record of several continents.

  20. The possibilities and limitation of transcultural biography work: Lithuanian case

    OpenAIRE

    Zemaitaityte I.; Mikulioniene S.; Dromantiene L.

    2014-01-01

    Lithuania, as well as other contemporary societies, is undergoing the times full of new technological, political, economic, social and scientific changes. In the changing society, adult education has helps a person to develop his and her cultural interests, creative powers, skills and acquire theoretical knowledge necessary for person's professional activity, enables a person to upgrade his or her current qualification and helps to become an active citizen of a democratic society (Zemaitaityt...

  1. Biography, history and the Indonesian novel : Reading Salah Asuhan

    Directory of Open Access Journals (Sweden)

    Keith Foulcher

    2005-01-01

    Full Text Available The novel Salah Asuhan (Wrong Upbringing, written by the Indonesian nationalist politician and journalist Abdoel Moeis, has long held an honoured place in the modern Indonesian literary canon. It was originally published in 1928 by Balai Poestaka, the Netherlands Indies government printing house, and by 1995 it had been reprinted twenty-three times. In summary form, it has been studied by generations of Indonesian schoolchildren, and in 1972 it was adapted by Asrul Sani as a successful feature film. Critics and historians of modern Indonesian literature have always regarded Salah Asuhan as a literary milestone. It is admired for the maturity of its author’s literary imagination, as well as the modernity of its language and style. In linguistic terms, it is seen as one of the pioneering literary expressions of the language which was designated as Bahasa Indonesia in the very year of the novel’s publication. It exercises an additional fascination for literary critics and historians because of the circumstances of its publication. The form in which it was originally written is now unknown, for the novel was only published after a lengthy delay and a series of revisions which the author made to the text after seeing his manuscript languish for more than a year under the scrutiny of Balai Poestaka’s editors. As a result, the original conception of Salah Asuhan remains a mystery. Indeed, it is one of the greatest puzzles in a literary history that is so full of documentary lacunae that its serious study remains a source of ongoing challenge and frustration.

  2. Defining moments : a cultural biography of Jane Eyre

    OpenAIRE

    2004-01-01

    This thesis examines the ways in which various practices, such as novel-writing, publishing, book-reviewing, reading for pleasure, adaptation and studying English literature, have produced Jane Eyre’s complex cultural profile. The organizing principle of the study is Paul du Gay, Stuart Hall et al’s ‘circuit of culture’, which identifies five key processes or ‘moments’ as being productive of the meanings that a cultural artefact or text comes to possess. Explaining the meanings which have bee...

  3. [Biography of the outstanding acupuncturist DU Xiao-shan].

    Science.gov (United States)

    Ding, Min; Lu, Rui-Qin; Du, Liang-Dong; Cao, Li; Lin, Tian-Yun

    2012-09-01

    Professor DU Xiao-shan 's academic thought and clinical experiences was introduced in this paper. He has noble medical ethics and is fair to the patients without distinction. He has great learning and rich practical experiences, and he specializes in all kinds of common diseases as well as many difficult and complicated cases. He never stops studying the ancients to make innovation and he creates the technique of the quick-puncture and slow-twist and DU's heat-reinforce method. He teaches to carry forward acupuncture and moxibustion and his achievements have become an important part of acupuncture and moxibustion science.

  4. Potential theory—selected topics

    CERN Document Server

    Aikawwa, Hiroaki

    1996-01-01

    The first part of these lecture notes is an introduction to potential theory to prepare the reader for later parts, which can be used as the basis for a series of advanced lectures/seminars on potential theory/harmonic analysis. Topics covered in the book include minimal thinness, quasiadditivity of capacity, applications of singular integrals to potential theory, L(p)-capacity theory, fine limits of the Nagel-Stein boundary limit theorem and integrability of superharmonic functions. The notes are written for an audience familiar with the theory of integration, distributions and basic functional analysis.

  5. Biography of louis braille and invention of the braille alphabet.

    Science.gov (United States)

    Jiménez, Javier; Olea, Jesús; Torres, Jesús; Alonso, Inmaculada; Harder, Dirk; Fischer, Konstanze

    2009-01-01

    Louis Braille (1809-1852) was born in France. At the age of three, he wounded his right eye with a cobbler's tool while playing in his father's workshop. No medical knowledge could save his eyesight at that time. Louis's left eye became inflamed, apparently due to subsequent sympathetic ophthalmia, and he eventually lost the sight in that eye. At the age of five, Louis Braille was completely blind. He is considered to be the inventor of a writing system by touch that bears his name, the Braille system. This revolutionary system has allowed blind people to access written culture, and it can therefore be considered a major advance in the quality of life for the blind. The immediate precursor of the invention of the Braille system was the alphabet created by Charles Barbier de la Serre (1767-1841) who created a language by touch designed for military and secret use. Louis Braille modified this alphabet into the Braille alphabet, which is practically the same one that is currently used. It required time to be recognized and to be implemented as a reading and writing method for blind people throughout the world. In 1950, UNESCO effectively universalized the Braille alphabet, and in 2005 it recognized Braille system as a "vital language of communication, as legitimate as all other languages in the world."

  6. Teacher History: Student Historians, Faculty Biographies, and the "Alma Mater"

    Science.gov (United States)

    Stofferahn, Steven A.

    2009-01-01

    When his department chair asked him a few years ago to take over as faculty advisor to their university's chapter of the Phi Alpha Theta history honor society, the author readily accepted. Not only would it provide a great opportunity to get to know some of their best students better, it would also help a junior faculty member like himself fulfill…

  7. Post scriptum to the biography of Monsieur Leborgne.

    Science.gov (United States)

    Domanski, Cezary W

    2014-01-01

    In 1861, Paul Broca presented a case of a patient who had almost completely lost the ability of speech production. This patient is known as "Monsieur Leborgne" alias "Tan." In describing the history of his disease, Broca reported that Leborgne had spent a total of 21 years in hospitals. The article features new information on the history of Leborgne's hospitalization.

  8. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A

    2008-01-01

    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  9. Learning in Life History - psycho-societal interpretation of biographies

    DEFF Research Database (Denmark)

    Olesen, Henning Salling

    2008-01-01

    Taking its point of departure from some critical remarks about some of the most important recent theorizing of learning, this article presents an alternative framework for theorizing learning as a subjective process in a social and societal context, based on life history research. The key concepts...

  10. Situated Learning in Young Romanian Roma Successful Learning Biographies

    Science.gov (United States)

    Nistor, Nicolae; Stanciu, Dorin; Vanea, Cornelia; Sasu, Virginia Maria; Dragota, Maria

    2014-01-01

    European Roma are often associated with social problems and conflicts due to poverty and low formal education. Nevertheless, Roma communities traditionally develop expertise in ethnically specific domains, probably by alternative, informal ways, such as situated learning in communities of practice. Although predictable, empirical evidence of…

  11. Chronicle Biography of Zeng Huai (Patr I)%曾怀年谱(上篇)

    Institute of Scientific and Technical Information of China (English)

    张小平

    2014-01-01

    Zeng Huai was prime minister in Xiao Zong’s reign of Southern Song Dynasty. He was engaged in financing at the grassroots level for a long time. He is famous for his administration in Ancient Chinese History,and especially a very influential person in the his-tory of Zeng clan in Jin Jiang. However,so far there is no chronicle biography about him in the academic circle. This paper tries to draft such a chronicle biography according to interrelated books in order to ask advice from the academic circle.%曾怀是南宋孝宗朝宰相,长期从事基层理财工作。为政有声,是中国古代史上,尤其是晋江曾氏家族历史上很有影响力的人物。迄今无年谱问世,该文据相关史籍文献,草成此谱,就教于学界。

  12. Digital Social Network Mining for Topic Discovery

    Science.gov (United States)

    Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

    Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

  13. Control of pain with topical plant medicines

    Institute of Scientific and Technical Information of China (English)

    James; David; Adams; Jr.; Xiaogang; Wang

    2015-01-01

    Pain is normally treated with oral nonsteroidal anti-inflammatory agents and opioids. These drugs are dangerous and are responsible for many hospitalizations and deaths. It is much safer to use topical preparations made from plants to treat pain, even severe pain. Topical preparations must contain compounds that penetrate the skin, inhibit pain receptors such as transient receptor potential cation channels and cyclooxygenase-2, to relieve pain. Inhibition of pain in the skin disrupts the pain cycle and avoids exposure of internal organs to large amounts of toxic compounds. Use of topical pain relievers has the potential to save many lives, decrease medical costs and improve therapy.

  14. The Biography of Doctor Charles Laugier (1875-1830).

    Science.gov (United States)

    Dinu, Elena Steluţa

    2014-01-01

    This paper presents the life and works of the famous doctor, hygienist, folklore researcher and sanitary mentor, Charles Laugier, whose contribution to the development of the medical system of Oltenia marked the beginning of the 20th century. He is noted for his research in hygiene, in the treatment of some diseases like: tuberculosis, malaria, pellagra, and also as the founder of numerous societies which contributed to the cultural and scientific development of the region of Oltenia and even of its small localities.

  15. Restabilizing attachment to cultural objects. Aesthetics, emotions and biography.

    Science.gov (United States)

    Benzecry, Claudio E

    2015-12-01

    The scholarship on aesthetics and materiality has studied how objects help shape identity, social action and subjectivity. Objects, as 'equipment[s] for living' (Luhmann 2000), become the 'obligatory passage points humans have to contend with in order to pursue their projects (Latour 1991). They provide patterns to which bodies can unconsciously latch onto, or help human agents work towards particular states of being (DeNora 2000, 2003). Objects are central in the long term process of taste construction, as any attachment to an object is made out of a delicate equilibrium of mediators, bodies, situations and techniques (Hennion and his collaborators (Hennion and Fouquet 2001; Hennion and Gomart 1999). In all of these accounts objects are the end result of long-term processes of stabilization, in which the actual material object (a musical piece, a sculpture, an art installation, a glass of wine, the oeuvre of Bach as we know it) is both a result and yet a key co-producer of its own generation. Whereas the literature has been generous and detailed in exploring the processes of assembling and sustaining object-centered attachments, it has not sufficiently engaged with what happens when the aesthetic elements of cultural artifacts that have produced emotional resonance are transformed: what do these artifacts morph into? What explains the transition (or not) of different cultural objects? And relatedly, what happens to the key aesthetic qualities that were so central to how the objects had been defined, and to those who have emotionally attached to them? To answer these questions, this article uses as exemplars two different cases of attachment, predicated on the distinctive features of a cultural object--the transcendence of opera and the authenticity of a soccer jersey--that have undergone transformations.

  16. Biography of Mădhavakara: his scholarly contribution.

    Science.gov (United States)

    Subhose, Varanasi; Srinivas, Pitta; Narayana, Ala

    2005-01-01

    Mădhavakara, the author of renowned work on 'Nidăna-Rŏgaviniścaya', popularly known as Mădhava Nidăna. It may be the first or earliest compendium detailed description of the diseases based on Nidăna Pancăkam (Five groups of subjects concerned to aetio-pathogenesis). He was the son of Indukara according to the colophon of a manuscript of Văcaspati's commentary on Mădhava Nidăna. He is probably lived between 700-800 A.D., because he is quoted by Vrnda, who belongs to 8th century A.D. The book Mădhava Nidăna was translated in to Arabic as evidenced by the writings of Ali Ibn Sahl 849-850 A.D. and other Arabic authors. Hence, he probably lived between 700-800 A.D. Madhava Nidana is a popular work on Nidăna (aetiopathogenesis) and it is the best in the field of ayurvĕda. "Nidăne Mădhavam srestah" and it is popularly known by the name of the author, but the title of the work is "Rugviniscaya" or "Rŏgaviniscăya". The subject matter explained in 73 chapters. The 1st chapter deals with Nidănapancakam and the other chapter's deals with diseases. The major contribution of Mădhava is the new order of arranging diseases, description of new diseases and recognizing some disorders as independent diseases. The other works attributed to Mădhava are Mădhavacikitsă, Paryăyaratnamăla etc. The important commentaries on Madhavanidana are "Madhukŏśa" by Vijayarakşita and Srĭkaņţhadatta and "Atankadarpana" by Vidyavăcaspati. The work is translated into English, Italian, Hindi, Bengali, Telugu etc., including some regional languages of India.

  17. "The Gaze Heuristic:" Biography of an Adaptively Rational Decision Process.

    Science.gov (United States)

    Hamlin, Robert P

    2017-02-21

    This article is a case study that describes the natural and human history of the gaze heuristic. The gaze heuristic is an interception heuristic that utilizes a single input (deviation from a constant angle of approach) repeatedly as a task is performed. Its architecture, advantages, and limitations are described in detail. A history of the gaze heuristic is then presented. In natural history, the gaze heuristic is the only known technique used by predators to intercept prey. In human history the gaze heuristic was discovered accidentally by Royal Air Force (RAF) fighter command just prior to World War II. As it was never discovered by the Luftwaffe, the technique conferred a decisive advantage upon the RAF throughout the war. After the end of the war in America, German technology was combined with the British heuristic to create the Sidewinder AIM9 missile, the most successful autonomous weapon ever built. There are no plans to withdraw it or replace its guiding gaze heuristic. The case study demonstrates that the gaze heuristic is a specific heuristic type that takes a single best input at the best time (take the best(2) ). Its use is an adaptively rational response to specific, rapidly evolving decision environments that has allowed those animals/humans/machines who use it to survive, prosper, and multiply relative to those who do not.

  18. SHADES OF VENICE IN THE BIOGRAPHY OF HEGUMEN PALLADY ROGOVSKY

    Directory of Open Access Journals (Sweden)

    Alex YASTREBOV

    2014-05-01

    Full Text Available Pallady Rogovsky was the fi rst Russian doctor of theology and philosophy. While a student of the Slavyano-Greek-Latin Academy directed by the Brothers Lichudes, he left his homeland for the West in order to obtain a full university education. The years which he spent in Europe and particularly in Italy have attracted little notice on the part of Church historians. The study of unpublished materials in Italian archives together with those already published by the Russian researcher E. Shmurlo from the archive of the Propaganda de Fide and the Greek College, which however, remain unnoticed for the great majority of academics, permit us to have an idea of what occupied Rogovsky during this time, as well as to draw a more precise portrait of his personality. Most remarkable is the fact of his priestly ordination in the Roman Catholic Church and the correspondence relating to Rome’s acceptance of his Russian Orthodox diaconal ordination. One of the most informative documents found among those relating to his ordination and addressed to the Roman Curia is the letter of a Russian Catholic, the deacon (later defrocked Petr Artem’ev, in which Artem’ev revealed that Rogovsky already had converted to Roman Catholicism before he left Russia. Equally noteworthy is Rogovsky’s own letter which he composed while in Venice and in which he formulated his plans for the propagation of Roman Catholicism in Russia.

  19. [Freud, the biography, his autobiography and his biographers].

    Science.gov (United States)

    de Mijolla, A

    1993-01-01

    Freud has a dual attitude to the biographical genre. When he places himself in the position of psychoanalyst-biographer of others, he is enthusiastic, speaking of ground to be conquered for psychoanalysis, and his works, as well as his correspondence, show that he continued to devote himself to investigations which resulted in interpretations of a number of personalities, the most detailed of which dealt with Leonardo de Vinci, Goethe, Dostoyevsky, President Wilson, and Moses. On the other hand, even though during the first years of the discovery of psychoanalysis he allowed himself, in a more or less veiled manner, confidences of an autobiographical nature, Freud remained very secretive about himself. He limited himself to making public only the routine information found on his university resume or the details of his life directly related to the discovery and the development of psychoanalysis. Hidden behind die Sache, the Cause, the man always vigorously defended himself against those who, braving the periodical destruction to which he subjected his archives, claimed to apply to him this "investigative drive" whose heuristic richness he otherwise celebrated. It is by means of fantasies of identification to the work, present in every biographical attempt, that we attempt to address here the contradictions of this dual attitude.

  20. Biography: Dr Iain Frame, director of research, prostate cancer UK.

    Science.gov (United States)

    Frame, Iain; Maprayil, Sophia

    2014-11-01

    Sophia Maprayil, Commissioning Editor for Expert Review of Anticancer Therapy, talks to Dr Iain Frame, Director of Research for Prostate Cancer UK. Iain is Prostate Cancer UK's first Director of Research, responsible for overseeing the development and implementation of the charity's ambitious new research strategy. He joined Prostate Cancer UK in 2012 from Diabetes UK where he held the post of Research Director for 5 years. Since joining Prostate Cancer UK in 2012 Iain has overseen a dramatic increase in the charity's research spend, from 2 million a year, to 7.5 million a year. Previously Iain worked in research management at the Wellcome Trust and before that as a parasitologist and researcher exploring various aspects of molecular biology of a number of different parasites.

  1. MRI evaluation of topical heat and static stretching as therapeutic modalities for the treatment of eccentric exercise-induced muscle damage.

    Science.gov (United States)

    Jayaraman, R C; Reid, R W; Foley, J M; Prior, B M; Dudley, G A; Weingand, K W; Meyer, R A

    2004-10-01

    The aim of this study was to monitor the effects of topical heat and/or static stretch treatments on the recovery of muscle damage by eccentric exercise. For this purpose, 32 untrained male subjects performed intense eccentric knee extension exercise, followed by 2 weeks of treatment (heat, stretch, heat plus stretch) or no treatment (control, n=8/group). Isometric strength testing, pain ratings, and multi-echo magnetic resonance imaging of the thigh were performed before and at 2, 3, 4, 8, and 15 days following the exercise. Increased T2 relaxation time, muscle swelling, pain ratings, and strength loss confirmed significant muscle damage during the post-exercise period. Pain ratings and muscle volume recovered to baseline by 15 days, although muscle strength remained lower [77 (4) vs. 95 (3) kg pre-exercise, mean (SE)] and T2 values higher [32.2 (0.8) vs. 28.6 (0.2) ms pre-exercise]. Our results indicate that heat and/or static stretching does not consistently reduce soreness, swelling or muscle damage. The practical implication of our findings is that clinicians should be aware that prescribing heat and/or static stretching following intense eccentric or unaccustomed exercise will not enhance the recovery of damaged muscles.

  2. TopicLens: Efficient Multi-Level Visual Topic Exploration of Large-Scale Document Collections.

    Science.gov (United States)

    Kim, Minjeong; Kang, Kyeongpil; Park, Deokgun; Choo, Jaegul; Elmqvist, Niklas

    2017-01-01

    Topic modeling, which reveals underlying topics of a document corpus, has been actively adopted in visual analytics for large-scale document collections. However, due to its significant processing time and non-interactive nature, topic modeling has so far not been tightly integrated into a visual analytics workflow. Instead, most such systems are limited to utilizing a fixed, initial set of topics. Motivated by this gap in the literature, we propose a novel interaction technique called TopicLens that allows a user to dynamically explore data through a lens interface where topic modeling and the corresponding 2D embedding are efficiently computed on the fly. To support this interaction in real time while maintaining view consistency, we propose a novel efficient topic modeling method and a semi-supervised 2D embedding algorithm. Our work is based on improving state-of-the-art methods such as nonnegative matrix factorization and t-distributed stochastic neighbor embedding. Furthermore, we have built a web-based visual analytics system integrated with TopicLens. We use this system to measure the performance and the visualization quality of our proposed methods. We provide several scenarios showcasing the capability of TopicLens using real-world datasets.

  3. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2014-07-01

    Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

  4. The ‘Cimarrón’ in the archives: a re-reading of Miguel Barnet’s biography of Esteban Montejo

    Directory of Open Access Journals (Sweden)

    Michael Zeuske

    1997-07-01

    Full Text Available [First paragraph] "Aunque por supuesto nuestro trabajo no es historico (Miguel Barnet" Apart from Manuel Moreno Fraginals's El ingenio, there is hardly any other book in Cuban historiography that has met with such wide circulation as Biografia de un cimarron by Miguel Barnet.1 It is, in spite of a series of contradictions, the classic in testimonio literature for contemporary studies on slavery as well as for the genre of historical slave narratives extending far beyond Cuba. In particular the various new editions and translations, such as the English versions that have been published under the titles Autobiography of a Runaway Slave (Barnet 1968, Autobiography of a Runaway Slave (Esteban Montejo & Miguel Barnet 1993 or Biography of a Runaway Slave (Barnet 1994 and the discussion that Barnet's book stimulated bear witness to this position.2

  5. Advanced verification topics

    CERN Document Server

    Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

    2011-01-01

    The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

  6. [Pathography and biography of the Empress Maria Theresa].

    Science.gov (United States)

    Habek, D; Masić, I

    2001-01-01

    The empress and queen Maria Theresa Habsburg-Lorraine (May 13th, 1917-November 29th, 1780) bore sixteen children in the marriage with the emperor Franz I Stepha and was famous as "mother-in-law of Europe". Her brother Leopold died immediately after he was born, her sister Amalia died in the cradle and Maria Ana died of perinatal complications at the birth of a dead infant in 1744. The famous hereditary facial dysmorphia of the "Hasburg jawe" wasn't noticed in Maria Theresa's surviving children. In October of 1738, after giving birth to her daughter Ana, a manual lysis of the placenta was performed due to the retained placenta and postpartal bleeding. In 1741 her daughter Carolina died, and in 1767 her daughter Josepha died of small pox. Her daughter Elizabeth remained deformed by the pock marks, and Maria Christina got a puerperal sepsis, but surprisingly, didn't die. Maria Antoinette ended under a guillotine in France, along with her husband Luis XVI. Maria Theresa's father, Karl VI died of the cholecystopankreatitis and peritonitis, and her husband and co-ruler most probably died of acute coronary incident in August 18th, 1765. After her husband's death she started suffering from depression with steady necrophile obsessions. Maria Theresa suffered from a chronical obstructional pulmonary disease (asthma), rehumatic syndromes, hypertension and anxiodepressive syndromes. In 1767 she had small pox. In November 11th 1780 she caught a cold which grew into a pneumonia with high fever. She died of cardiopulmonal dedompensation preceded by pneumonia and asthma.

  7. Topic Prominence in Japanese EFL Students' Existential Constructions.

    Science.gov (United States)

    Sasaki, Miyuki

    1990-01-01

    Investigations of Japanese speakers' interlanguage constructions of English existential sentences with a locative sentential topic found a general shift from topic-comment to subject-predicate structures as proficiency increased. (24 references) (Author/CB)

  8. Hierarchical topic modeling with nested hierarchical Dirichlet process

    Institute of Scientific and Technical Information of China (English)

    Yi-qun DING; Shan-ping LI; Zhen ZHANG; Bin SHEN

    2009-01-01

    This paper deals with the statistical modeling of latent topic hierarchies in text corpora. The height of the topic tree is assumed as fixed, while the number of topics on each level as unknown a priori and to be inferred from data. Taking a nonparametric Bayesian approach to this problem, we propose a new probabilistic generative model based on the nested hierarchical Dirichlet process (nHDP) and present a Markov chain Monte Carlo sampling algorithm for the inference of the topic tree structure as welt as the word distribution of each topic and topic distribution of each document. Our theoretical analysis and experiment results show that this model can produce a more compact hierarchical topic structure and captures more free-grained topic relationships compared to the hierarchical latent Dirichlet allocation model.

  9. Biografia intelektualna Emila Ciorana (Emil Cioran's Intellectual Biography

    Directory of Open Access Journals (Sweden)

    Sławomir Piechaczek

    2011-06-01

    Full Text Available On the formation of Cioran’s vision of the world and man, influenced largely his belonging to precisely this and no other nation. Romanian fatalism, inability to illusions, seeing the inevitable, the Romanian people’s faith in the fact that sin and creation are the same and constant accusations against this creation are the constitutiveelements of Cioran’s thought. Carrying the baggage of experiences of the nation thrown out of history and time, Cioran, as a Romanian emigrant in France, found the best model for his own writing in rhetorical and satirical tradition of the French moralists of the seventeenth and eighteenth centuries, who were a combination of“lyrical sublimity and cynicism”, gentleness and hell. They showed him not only what is uncompromising in pursuing the motives of human action, looking at every thing from many different perspectives, or suspicion of any kind of doctrine, but they also became for him a model of style. Of all literary forms cultivated by moralists, Cioranappreciated most the fragment, that is to say a closed form, often paradoxical and witty that having nothing in common with the characteristic for large systems long strings of argument – that was a form of recording experience, and like this experience, assumed discontinuity. Being a spokesperson for the “philosophy of the onlymoments”, Cioran advocated not only against the system, but also against academic philosophy – grown with indifference, regardless of the state of mind, it seemed to him the result of reduction of vitality and a kind of escape into the impersonal world of unrest. State, which fully made Cioran realize the futility resorting to this kind of philosophy, was insomnia, from which the Romanian philosopher had suffered more or less since he was seventeen. According to the author of the Fall in the Time insomnia and boredom are the “minimum imbalance”, which we have to experience, when we want to get closer to some

  10. Topical cidofovir for plantar warts.

    Science.gov (United States)

    Padilla España, Laura; Del Boz, Javier; Fernández Morano, Teresa; Arenas Villafranca, Javier; de Troya Martín, Magdalena

    2014-01-01

    Plantar warts are a common reason for dermatological consultations and their treatment can occasionally be a challenge. Plantar warts are benign lesions produced by the human papillomavirus (HPV) that often fail to respond to habitual treatment. Cidofovir is a potent antiviral drug that acts competitively, inhibiting viral DNA polymerase. Our aim was to assess the efficacy and safety of cidofovir cream for the treatment of viral plantar warts. We undertook a retrospective observational study of patients with plantar warts who received treatment with topical cidofovir between July 2008 and July 2011 at the Dermatology Service of the Hospital Costa del Sol, Marbella, Spain. Data about the rate of treatment response, the adverse effects, and recurrences, as well as the characteristics of the patient cohort, were recorded. We identified 35 patients who had received some previous treatment. The usual concentration was 3% (in 33 of 35 cases), applied twice a day (in 31 of 35 cases). A greater or lesser response was noted in 28 cases. There were two recurrences. Topical cidofovir seems to be a useful alternative for the therapeutic management of recalcitrant plantar common warts that fail to respond to usual treatment.

  11. Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro &in vivo.

    Science.gov (United States)

    Zhang, Chen-Zhen; Niu, Jie; Chong, Yee-Song; Huang, Yan-Fen; Chu, Yang; Xie, Sheng-Yang; Jiang, Zhi-Hong; Peng, Li-Hua

    2016-12-01

    Asiaticoside is a natural compound possessing diverse pharmacological effects with great potential for clinical use. However, the low solubility and oil-water partition coefficient of asiaticoside lead to reduced effect and limited application. This study aims to construct a porous microsphere for the sustained release of asiaticoside to improve its absorption and enhance the therapeutic effects. Parameters of the formulations, including the drug to polymer ratio, solvent amounts of the inner and external phases, the stirring speed for preparation, and the drug entrapment efficiency were investigated and optimized. Particle size, morphology, pores structure, and Fourier transform infrared spectrum of the microsphere were characterized. The release kinetics and cellular uptake profiles of the asiaticoside-microspheres were examined. The therapeutic effects of asiaticoside-microspheres on wound healing and skin appendages regeneration were investigated in vitro & in vivo. Results showed that the optimized asiaticoside-microspheres possess spherical spongy structure with cylindrical holes. Asiaticoside can be loaded in the microsphere with high efficiency and released with sustained manner. The cellular uptake of asiaticoside from the microspheres was increased with 9.1 folds higher than that of free solution. Asiaticoside-microspheres expressed the strong promotion in the proliferation, migration of keratinocytes and wound scratching healing in vitro. More importantly, they significantly accelerated the re-epithelization, collagen synthesis and pro-angiogenesis in the rat full-skin wound healing. Porous microsphere was shown a novel carrier for the sustained delivery of poorly soluble asiaticoside, with absorption and therapeutic effects improved. Asiaticoside-microsphere is a promising topical preparation with excellent regenerative effects for the wound therapy.

  12. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume II. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    The biographies in this projected eight volume series for elementary school children represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures with national origins in the United States or Latin America, with careers that cover many aspects of contemporary life. Every person profiled in the series…

  13. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume III. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    The biographies in this projected eight volume series for elementary school children represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures with national origins in the United States or Latin America, with careers that cover many aspects of contemporary life. Every person profiled in the series…

  14. Famous People of Hispanic Heritage. Contemporary American Success Stories, Volume IX. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Cole, Melanie; Marvis, Barbara J.; Menard, Valerie

    Biographies in this series represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures whose national origins range from Argentina to the United States, and whose careers and contributions cover many aspects of American life. Each person profiled is a positive role model, not only for people of…

  15. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume VI. A Mitchell Lane Multicultral Biography Series.

    Science.gov (United States)

    1997

    The term "Hispanic" is an umbrella term that encompasses people from many nationalities, all races, and many social and cultural groups. Hispanics are also collectively called Latinos. The biographies in this series represent the diversity of Hispanic heritage in the United States. The people featured are contemporary figures of…

  16. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume V. A Mitchell Lane Multicultral Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    The term "Hispanic" is an umbrella term that encompasses people from many nationalities, all races, and many social and cultural groups. Hispanics are also collectively called Latinos. The biographies in this series represent the diversity of Hispanic heritage in the United States. The people featured are contemporary figures of…

  17. Famous People of Hispanic Heritage. Contemporary American Success Stories, Volume VIII. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Menard, Valerie; Cole, Melanie

    Biographies in this series represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures whose national origins range from Argentina to the United States, and whose careers and contributions cover many aspects of American life. Each person profiled is a positive role model, not only for people of…

  18. Famous People of Hispanic Heritage. Contemporary American Success Stories, Volume VII. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara; Cole, Melanie; Cantu, Tony

    The term "Hispanic" is an umbrella term that encompasses people from many nationalities, all races, and many social and cultural groups. Biographies in this series represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures whose national origins range from Argentina to the United States,…

  19. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume I. A Mitchell Lane Multicultural Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    This series presents biographical sketches of famous Americans of Hispanic descent. The biographies in the projected eight volume series for elementary school children represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures with national origins in the United States or Latin America, with careers…

  20. Contemporary American Success Stories: Famous People of Hispanic Heritage. Volume IV. A Mitchell Lane Multicultral Biography Series.

    Science.gov (United States)

    Marvis, Barbara J.

    The term "Hispanic" is an umbrella term that encompasses people from many nationalities, all races, and many social and cultural groups. Hispanics are also collectively called Latinos. The biographies in this series represent the diversity of Hispanic heritage in the United States. The people featured are contemporary figures of…

  1. Synergetics introduction and advanced topics

    CERN Document Server

    Haken, Hermann

    2004-01-01

    This book is an often-requested reprint of two classic texts by H. Haken: "Synergetics. An Introduction" and "Advanced Synergetics". Synergetics, an interdisciplinary research program initiated by H. Haken in 1969, deals with the systematic and methodological approach to the rapidly growing field of complexity. Going well beyond qualitative analogies between complex systems in fields as diverse as physics, chemistry, biology, sociology and economics, Synergetics uses tools from theoretical physics and mathematics to construct an unifying framework within which quantitative descriptions of complex, self-organizing systems can be made. This may well explain the timelessness of H. Haken's original texts on this topic, which are now recognized as landmarks in the field of complex systems. They provide both the beginning graduate student and the seasoned researcher with solid knowledge of the basic concepts and mathematical tools. Moreover, they admirably convey the spirit of the pioneering work by the founder of ...

  2. Generative Topic Modeling in Image Data Mining and Bioinformatics Studies

    Science.gov (United States)

    Chen, Xin

    2012-01-01

    Probabilistic topic models have been developed for applications in various domains such as text mining, information retrieval and computer vision and bioinformatics domain. In this thesis, we focus on developing novel probabilistic topic models for image mining and bioinformatics studies. Specifically, a probabilistic topic-connection (PTC) model…

  3. The Impact of Topic Congruence on Second Language Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Marzieh Sadeghpour

    2013-09-01

    Full Text Available The present study scrutinized the impact of congruent topics on the quality of L2 reading comprehension. 56 Iranian advanced-level students read 2 texts on a controversial topic, one on the advantages of child gender selection, and the other on disadvantages. Quality analysis of immediate and delayed recall tasks, defined as the amount of high and low-level information recalled correctly, was performed by analysis of variance. Results revealed that topic congruence affected immediate recall of both high and low-level information, and also delayed recall of low-level information. Findings showed that the effect of congruent topics on reading recall was detrimental; participants recalled less information from the passage with congruent topic than a passage with incongruent topic. Outcomes of the study suggest that controversial topics should be selected more cautiously, because they may not truly reflect L2 readers’ reading comprehension. Keywords: congruent topic, L2 reading, readers’ attitude, immediate recall, delayed recall

  4. Topical steroid addiction in atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Fukaya M

    2014-10-01

    Full Text Available Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. Keywords: topical steroid addiction, atopic dermatitis, red burning skin syndrome, rebound, corticosteroid, eczema

  5. Genius in the shadows a biography of Leo Szilard, the man behind the bomb

    CERN Document Server

    Lanouette, William

    2013-01-01

    Well-known names such as Albert Einstein, Enrico Fermi, J. Robert Oppenheimer, and Edward Teller are usually those that surround the creation of the atom bomb. One name that is rarely mentioned is Leo Szilard, known in scientific circles as "father of the atom bomb." The man who first developed the idea of harnessing energy from nuclear chain reactions, he is curiously buried with barely a trace in the history of this well-known and controversial topic.Born in Hungary and educated in Berlin, he escaped Hitler's Germany in 1933 and that first year developed his concept of nucle

  6. A life of Erwin Schroedinger. 2. ed.; Erwin Schroedinger. Eine Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Walter J.

    2015-07-01

    Erwin Schroedinger (1887-1961) was a pioneer of quantum physics, one of the most important scientist of the 20th century at all and a charming Austrian. He was a man with a passionate interest for men and ideas. Mostly known he became by his representation of quantum theory in the form of wave mechanics, for which he obtained the Nobel prize for physics and naturally by the famous thought experiment ''Schroedingers cat''. Walter Moore's biography is quite near to the person of Schroedinger and presents his scientific work in the context of his friendships, his interset for mysticism, and in front of the moving background of the political events in Germany and Austria.

  7. éphémérides ou biographie sommaire de Savinien de Cyrano de Bergerac

    Directory of Open Access Journals (Sweden)

    Madeleine Alcover

    2010-02-01

    Full Text Available Biographie15519 avril : mariage, à Paris, des grands-parents paternels de l’écrivain, Savinien I de Cyrano et Anne Le Maire : celle-ci est la petite-fille d’Étienne Cardon, marchand parisien. À ce jour, l’origine du grand-père paternel n’est pas résolue (sarde ? descendant d’un marchand bourrelier de Sens ?.1555Le couple signe une donation entre vifs qui, en cas de décès, fait du survivant son légataire universel. Quatre enfants leur survivront : Abel, Samuel, Pierre et Anne.1555-1560Savinie...

  8. 《明史・万贵妃传》的史源及考疑%Textual Criticism of Biography of Concubine Wan in the History of Ming

    Institute of Scientific and Technical Information of China (English)

    纪海龙

    2014-01-01

    The Xianzong's favored concubine Wan has been describes as a woman who is guilty of the most hideous crime in the Ming and Qing dynasties'historical sources .In the view of official historians , her main “crimes”as follows ,monopolizing the love of the Xianzong ,forcing other concubines to abortion , murdering concubine Ji and colluding with crafty sycophants etc .According to the investigation ,most his-torical sources of the biography of concubine Wan in the history of Ming come from the Ming and Qing dy -nasties'literati notes .Once analyzing these notes carefully ,we can find some contradictions .Therefore ,it is necessary to clarify and identify the biography of historical sources .%在明清两代的史料中,明宪宗宠妃万氏,一直被描述成一个工于心计且罪大恶极的女人。在史官的笔下,她的主要“罪名”有擅宠、伤堕皇嗣、谋害纪淑妃、勾结佞倖等。据考察《明史・万贵妃传》中的史料多源于明清文人的笔记。仔细推敲这些关于万贵妃的笔记时,能够发现这些记载万贵妃的笔记有些许矛盾之处。故而,理清《明史・万贵妃传》的史料来源并加以辨析就有其必要性了。

  9. Notes about Censorship and Self-Censorship in the Biography of the Prophet Muḥammad

    Directory of Open Access Journals (Sweden)

    Lecker, Michael

    2014-06-01

    Full Text Available The study of the medieval literary output about Muḥammad’s life should go hand in hand with the study of his history, for which we have rich evidence in a variety of sources. Ibn Isḥāq’s biography of Muḥammad and its epitome by Ibn Hishām were products of their time. A case of self-censorship applied by one of Ibn Isḥāq’s informants and two cases of censorship applied by Ibn Hishām, who omitted many of his predecessor’s materials, contribute to a better understanding of the social and political context of the biography.El estudio de la producción literaria medieval sobre la vida de Muḥammad debe ir de la mano del estudio de su historia, empresa para la que disponemos de rica información en una variedad de fuentes. La biografía de Muḥammad por Ibn Isḥāq y su epítome por Ibn Hišām fueron productos de su época. Un caso de auto-censura aplicado por uno de los informantes de Ibn Isḥāq y dos casos de censura aplicados por Ibn Hišām, quien omitió muchos de los materiales de su predecesor, contribuyen a una mejor comprensión del contexto social y político de la biografía del Profeta.

  10. Neutron transport simulation (selected topics)

    Science.gov (United States)

    Vaz, P.

    2009-10-01

    Neutron transport simulation is usually performed for criticality, power distribution, activation, scattering, dosimetry and shielding problems, among others. During the last fifteen years, innovative technological applications have been proposed (Accelerator Driven Systems, Energy Amplifiers, Spallation Neutron Sources, etc.), involving the utilization of intermediate energies (hundreds of MeV) and high-intensity (tens of mA) proton accelerators impinging in targets of high Z elements. Additionally, the use of protons, neutrons and light ions for medical applications (hadrontherapy) impose requirements on neutron dosimetry-related quantities (such as kerma factors) for biologically relevant materials, in the energy range starting at several tens of MeV. Shielding and activation related problems associated to the operation of high-energy proton accelerators, emerging space-related applications and aircrew dosimetry-related topics are also fields of intense activity requiring as accurate as possible medium- and high-energy neutron (and other hadrons) transport simulation. These applications impose specific requirements on cross-section data for structural materials, targets, actinides and biologically relevant materials. Emerging nuclear energy systems and next generation nuclear reactors also impose requirements on accurate neutron transport calculations and on cross-section data needs for structural materials, coolants and nuclear fuel materials, aiming at improved safety and detailed thermal-hydraulics and radiation damage studies. In this review paper, the state-of-the-art in the computational tools and methodologies available to perform neutron transport simulation is presented. Proton- and neutron-induced cross-section data needs and requirements are discussed. Hot topics are pinpointed, prospective views are provided and future trends identified.

  11. Neutron transport simulation (selected topics)

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, P. [Instituto Tecnologico e Nuclear, Estrada Nacional 10, P-2686-953 Sacavem (Portugal)], E-mail: pedrovaz@itn.pt

    2009-10-15

    Neutron transport simulation is usually performed for criticality, power distribution, activation, scattering, dosimetry and shielding problems, among others. During the last fifteen years, innovative technological applications have been proposed (Accelerator Driven Systems, Energy Amplifiers, Spallation Neutron Sources, etc.), involving the utilization of intermediate energies (hundreds of MeV) and high-intensity (tens of mA) proton accelerators impinging in targets of high Z elements. Additionally, the use of protons, neutrons and light ions for medical applications (hadrontherapy) impose requirements on neutron dosimetry-related quantities (such as kerma factors) for biologically relevant materials, in the energy range starting at several tens of MeV. Shielding and activation related problems associated to the operation of high-energy proton accelerators, emerging space-related applications and aircrew dosimetry-related topics are also fields of intense activity requiring as accurate as possible medium- and high-energy neutron (and other hadrons) transport simulation. These applications impose specific requirements on cross-section data for structural materials, targets, actinides and biologically relevant materials. Emerging nuclear energy systems and next generation nuclear reactors also impose requirements on accurate neutron transport calculations and on cross-section data needs for structural materials, coolants and nuclear fuel materials, aiming at improved safety and detailed thermal-hydraulics and radiation damage studies. In this review paper, the state-of-the-art in the computational tools and methodologies available to perform neutron transport simulation is presented. Proton- and neutron-induced cross-section data needs and requirements are discussed. Hot topics are pinpointed, prospective views are provided and future trends identified.

  12. The topical treatment of psoriasis.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Vissers, W.H.P.M.

    2003-01-01

    According to the patients, improvement of efficacy, long-term safety and improvement of compliance are needed. The topical treatment has been innovated during the last decade. Most important are the introduction of two new classes of treatments: topical vitamin D(3) analogues and the retinoid tazaro

  13. Topics of Evolutionary Computation 2001

    DEFF Research Database (Denmark)

    Ursem, Rasmus Kjær

    This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem......This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem...

  14. Topics in Banach space theory

    CERN Document Server

    Albiac, Fernando

    2016-01-01

    This text provides the reader with the necessary technical tools and background to reach the frontiers of research without the introduction of too many extraneous concepts. Detailed and accessible proofs are included, as are a variety of exercises and problems. The two new chapters in this second edition are devoted to two topics of much current interest amongst functional analysts: Greedy approximation with respect to bases in Banach spaces and nonlinear geometry of Banach spaces. This new material is intended to present these two directions of research for their intrinsic importance within Banach space theory, and to motivate graduate students interested in learning more about them. This textbook assumes only a basic knowledge of functional analysis, giving the reader a self-contained overview of the ideas and techniques in the development of modern Banach space theory. Special emphasis is placed on the study of the classical Lebesgue spaces Lp (and their sequence space analogues) and spaces of continuous f...

  15. KEY TOPICS IN SPORTS MEDICINE

    Directory of Open Access Journals (Sweden)

    Amir Ali Narvani

    2006-12-01

    Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

  16. Topical treatment options for conjunctival neoplasms

    Directory of Open Access Journals (Sweden)

    Jonathan W Kim

    2008-10-01

    Full Text Available Jonathan W Kim, David H AbramsonOphthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical agents have been used by investigators to treat various premalignant and malignant lesions of the conjunctiva, such as primary acquired melanosis with atypia, conjunctival melanoma, squamous intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and pagetoid spread of the conjunctiva arising from sebaceous cell carcinoma. Despite the enthusiasm generated by the success of these agents, there are unanswered questions regarding the clinical efficacy of this new nonsurgical approach, and whether a single topical agent can achieve cure rates comparable with traditional therapies. Furthermore, the long-term consequences of prolonged courses of topical chemotherapeutic drugs on the ocular surface are unknown, and the ideal regimen for each of these agents is still being refined. In this review, we present specific guidelines for treating both melanocytic and squamous neoplasms of the conjunctiva, utilizing the available data in the literature as well as our own clinical experience at the Memorial Sloan-Kettering Cancer Center.Keywords: topical therapies, conjunctival neoplasms melanosis, Mitomycin-C, 5-Fluorouracil

  17. Safety of topical vancomycin powder in neurosurgery

    Directory of Open Access Journals (Sweden)

    Kalil G Abdullah

    2016-01-01

    Full Text Available Surgical site infections (SSIs remain an important cause of morbidity following neurosurgical procedures despite the best medical practices. In addition, hospital infection rates are proposed as a metric for ranking hospitals safety profiles to guide medical consumerism. Recently, the use of topical vancomycin, defined as the application of vancomycin powder directly into the surgical wound, has been described in both cranial and spinal surgeries as a method to reduce SSIs. Early results are promising. Here, we provide a concise primer on the pharmacology, bacterial spectrum, history, and clinical indications of topical vancomycin for the practicing surgeon.

  18. Topics in general topology

    CERN Document Server

    Morita, K

    1989-01-01

    Being an advanced account of certain aspects of general topology, the primary purpose of this volume is to provide the reader with an overview of recent developments.The papers cover basic fields such as metrization and extension of maps, as well as newly-developed fields like categorical topology and topological dynamics. Each chapter may be read independently of the others, with a few exceptions. It is assumed that the reader has some knowledge of set theory, algebra, analysis and basic general topology.

  19. Risk assessment of topically applied products

    DEFF Research Database (Denmark)

    Søborg, Tue; Basse, Line Hollesen; Halling-Sørensen, Bent

    2007-01-01

    The human risk of harmful substances in semisolid topical dosage forms applied topically to normal skin and broken skin, respectively, was assessed. Bisphenol A diglycidyl ether (BADGE) and three derivatives of BADGE previously quantified in aqueous cream and the UV filters 3-BC and 4-MBC were used...... as model compounds. Tolerable daily intake (TDI) values have been established for BADGE and derivatives. Endocrine disruption was chosen as endpoint for 3-BC and 4-MBC. Skin permeation of the model compounds was investigated in vitro using pig skin membranes. Tape stripping was applied to simulate broken...... parameters for estimating the risk. The immediate human risk of BADGE and derivatives in topical dosage forms was found to be low. However, local treatment of broken skin may lead to higher exposure of BADGE and derivatives compared to application to normal skin. 3-BC permeated skin at higher flux than 4-MBC...

  20. Topical therapy in atopic dermatitis in children

    Directory of Open Access Journals (Sweden)

    Dharshini Sathishkumar

    2016-01-01

    Full Text Available Atopic dermatitis (AD is a common, chronic childhood skin disorder caused by complex genetic, immunological, and environmental interactions. It significantly impairs quality of life for both child and family. Treatment is complex and must be tailored to the individual taking into account personal, social, and emotional factors, as well as disease severity. This review covers the management of AD in children with topical treatments, focusing on: education and empowerment of patients and caregivers, avoidance of trigger factors, repair and maintenance of the skin barrier by correct use of emollients, control of inflammation with topical corticosteroids and calcineurin inhibitors, minimizing infection, and the use of bandages and body suits.

  1. Azelaic Acid Topical

    Science.gov (United States)

    ... the bacteria that infect pores and by decreasing production of keratin, a natural substance that can lead ... drinks, spicy foods, and hot drinks such as coffee and tea.If you have acne, continue your ...

  2. Emerging topics in FXTAS

    DEFF Research Database (Denmark)

    Hall, Deborah A; Birch, Rachael C; Anheim, Mathieu

    2014-01-01

    This paper summarizes key emerging issues in fragile X-associated tremor/ataxia syndrome (FXTAS) as presented at the First International Conference on the FMR1 Premutation: Basic Mechanisms & Clinical Involvement in 2013....

  3. Erythromycin and Benzoyl Peroxide Topical

    Science.gov (United States)

    The combination of erythromycin and benzoyl peroxide is used to treat acne. Erythromycin and benzoyl peroxide are in a class of medications called topical antibiotics. The combination of erythromycin ...

  4. Clindamycin and Benzoyl Peroxide Topical

    Science.gov (United States)

    The combination of clindamycin and benzoyl peroxide is used to treat acne. Clindamycin and benzoyl peroxide are in a class of medications called topical antibiotics. The combination of clindamycin ...

  5. Safety and Health Topics: Asbestos

    Science.gov (United States)

    ... Videos E-Tools Safety and Health Topics / Asbestos Asbestos This page requires that javascript be enabled for ... Hazards and Toxic Substances Hazardous Waste What is asbestos? Asbestos is the name given to a group ...

  6. Integrating Case Topics in Medical School Curriculum to Enhance Multiple Skill Learning: Using Fetal Alcohol Spectrum Disorders as an Exemplary Case

    Science.gov (United States)

    Paley, Blair; O'Connor, Mary J.; Baillie, Susan J.; Guiton, Gretchen; Stuber, Margaret L.

    2009-01-01

    Objectives: This article describes the use of fetal alcohol spectrum disorders (FASDs) as a theme to connect the learning of basic neurosciences with clinical applications across the age span within a systems-based, integrated curricular structure that emphasizes problem-based learning. Methods: In collaboration with the Centers for Disease…

  7. FORMULATION AND DEVELOPMENT OF TOPICAL NIOSOMAL GEL OF BCS CLASS - III ANTI-VIRAL DRUG FOR BETTER EFFICACY AS HERPES TREATMENT

    Directory of Open Access Journals (Sweden)

    Modi Kushal A.

    2012-03-01

    Full Text Available The objective of present research work was to formulate niosomal gel of ACV and to evaluate it for enhancements of skin permeation and skin retention characteristics. ACV niosomes were prepared by classical thin layer hydration method. The niosomal vesicles were separated by centrifugation method and further evaluated for percentage drug entrapment (PDE and vesicle mean geometric diameter. The separated niosomal vesicles were incorporated into the Carbopol® 971 gel base. The niosomal gel was further evaluated for skin retention characteristics, in vitro diffusion study and stability studies at accelerated and non-accelerated conditions. The batch F12 was considered as optimized batch as it showed minimum geometric mean diameter of vesicles (1.23 ± 0.19 μm and maximum PDE (58.71 ± 0.89 %. The in vitro diffusion study using human cadaver skin (HCS showed 1.57 times higher flux as compared to conventional ACV gel. The skin retention study reveals that the percentage drug retained was 4.92 times higher as compared to conventional ACV gel. The stability studies at 2-8 °C showed PDE 94.23% after 12 weeks whereas at accelerated condition it was found to be 90.11%.

  8. A Problematic Family Reunion of a Chinese-American in China: Issues of Face Abstract: As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses thr...%ract: As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses three critical incidents based on two face theories proposed by Brown and Levinson ...

    Institute of Scientific and Technical Information of China (English)

    曹凤琴

    2012-01-01

    As one of the heated topics in the intercultural communication studies, face issues have aroused world-wide attention in the academic field. This paper analyses three critical incidents based on two face theories proposed by Brown and Levinson (1987) and Ting-Toomey and Kurogi(1998) respectively. Lastly, by focusing on the relationship between the rapport-threatening behavior and the face, this paper intends to cultivate our awareness of face and highlight the harmonious interpersonal relationship between different cultures.

  9. 逍遥游在一传中--《逍遥游·庄子传》的运思方式%The Carefree Excursion in Biography of Zhuangzi---Thinking Mode of Biography of Unfettered,Zhuangzi

    Institute of Scientific and Technical Information of China (English)

    李耀中

    2015-01-01

    王充闾的《逍遥游·庄子传》,对庄子进行散文笔法的生平传写,既有传记的真实,又有文学性的描述,踵事增华,足见庄子历史原本的存在。传记的运思中把庄子放在战国的历史时空中加以考量,把《庄子》文本以传述的需要,化入史进的历程,刻画出千古无二的庄子,显示了传作者的现实关怀,很能引发今日读庄人的深入思考。%Wang Chong lv“Biography of unfettered,Zhuangzi”has the truth of biography and description of literari-ness,which can demonstrate the existence of the original works. The thought of biography writing puts Zhuangzi in the history of Warring States,makes the works fade in the course of history and portray unique Zhuang zi,which shows the author′s real concern,and arouses the thought of readers.

  10. Topics of Bioengineering in Wikipedia

    Directory of Open Access Journals (Sweden)

    Vassia Atanassova

    2009-10-01

    Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

  11. Topics in modern differential geometry

    CERN Document Server

    Verstraelen, Leopold

    2017-01-01

    A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

  12. Scopus vs WOS as scientific evaluation tools:A comparative analysis based on a testing sample search on the topic of electric vehicles

    Institute of Scientific and Technical Information of China (English)

    WANG; Na; PAN; Yuntao; MA; Zheng; WU; Yishan

    2010-01-01

    Based on a bibliometric analysis in combination with other information analysis methods,this paper compares the different evaluation results on the subject of"electric vehicles"drawn from Web of Science(WOS)and from Scopus.We came to the following conclusions after a careful comparison of these two databases.Firstly,both WOS and Scopus would provide some valid and unique evaluation indicators.Secondly,they showed similar results in terms of evaluating research performance of countries and research organizations involved in the targeted subject fields.In fact,both databases are good for discovering the research trend in general at the macroscopic level.Lastly,we ought to take the disciplinary characteristics,the extent of journal inclusion and resource selection criteria as well as inevitable data errors into full account in making recommendations to policy decision-makers.

  13. Sarcoidosis - Main Topic

    Directory of Open Access Journals (Sweden)

    Nilgün Solak Tekin

    2012-09-01

    Full Text Available Sarcoidosis is a multisystemic, inflammatory disease of unknown etiology that is characterized by noncaseating granulomas. Approximately, one-third of the patients with systemic sarcoidosis are observed cutaneous manifestations of different morphologies. Skin sarcoidosis have extremely heterogeneous clinical picture, so it is defined as “The Great Imitator” or “clinical chameleon”.

  14. Water: A Topic for All Sciences

    Science.gov (United States)

    Davies, Malonne I.; Seimears, C. Matt

    2008-01-01

    The authors illustrate an effective lesson-planning technique known as unpacking for the broad topic of water. Interconnections among science disciplines are shown for numerous possible subtopics. Two lesson sets are included, the first dealing with properties of water and the second dealing with water as a resource. (Contains 1 table and 4…

  15. The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model for topical anti-proliferative drugs

    DEFF Research Database (Denmark)

    Jensen, M.; Groth, L.; Fullerton, A.;

    2002-01-01

    , histology of the epidermis and fatty acid analysis of serum and skin. Immediately after the EFAD condition had been established, the animals were treated with dithranol ointment or different concentrations of calcipotriol solution. A reduction in epidermal thickness of 15-20% was seen after the treatment...... with calcipotriol. Dithranol and its coal tar-containing vehicle also showed a reductive effect on epidermal thickness. EFAD hairless rats possess various histological changes resembling psoriasis. These histological changes normalise during treatment with anti-psoriatic drugs as calcipotriol, dithranol and coal...

  16. USSOCOM Research Topics 2012

    Science.gov (United States)

    2012-01-01

    Mexico : Uneasy Past and Challenging Future, March 2010, Graham H. Turbiville, Jr. Report of Proceedings, Joint Special Operations University (JSOU...Foreign Area Officer ( FAO ) programs or develop a parallel SOF-specific career track? Should there be language, country experience, and rank requirements... Mexico . In the case of the latter, NORTHCOM SOD is likely to grow in importance. In addition, as SOCJFCOM is being eliminated, some missions and

  17. Functional peptide nanocarriers for delivery of novel anti-RelA RNA interference agents as a topical treatment of atopic dermatitis.

    Science.gov (United States)

    Kanazawa, Takanori; Hamasaki, Tomohiro; Endo, Takahiro; Tamano, Kuniko; Sogabe, Kana; Seta, Yasuo; Ohgi, Tadaaki; Okada, Hiroaki

    2015-07-15

    Small interfering RNAs (siRNAs) are a potential treatment of atopic dermatitis (AD) because they can specifically silence the gene expression of AD-related factors. However, siRNA alone cannot exert a sufficiently strong therapeutic effect due to low delivery efficiency to the target tissues and cells; simply increasing the amount used is not possible due to the possibility of off-target effects. We previously reported a novel class of therapeutic RNA interference (RNAi) agents called nkRNA(®) and PnkRNA(®), which have been shown to be effective in several disease models, have greater resistance to nuclease degradation than canonical siRNAs, and do not induce any immunotoxicity. In the present study, we describe a non-invasive and effective transdermal RNAi therapeutic system for atopic dermatitis that uses the functional cell-penetrating stearoyl-oligopeptide OK-102 as a cytoplasm-responsive nanocarrier for nkRNA(®) and PnkRNA(®). The two RNAi agents were targeted against RelA, a subclass of NF-κB (nuclear factor kappa B), and, as part of OK-102 complexes, they strongly silenced RelA mRNA in macrophage cells and demonstrated a significant therapeutic effect in a mouse model of AD. It was shown that OK-102-complexed RNAi agents were an efficient therapeutic system for AD and caused no adverse reactions.

  18. PLANT RAW MATERIAL EXTRACTS AS COMPONENTS OF COSMETIC PRODUCTS AND FORMULATIONS FOR TOPICAL ADMINISTRATION: THE PRODUCT RANGE, THE PRODUCTION CHARACTERISTICS (REVIEW

    Directory of Open Access Journals (Sweden)

    S. B. Evseeva

    2016-01-01

    Full Text Available In contemporary pharmaceutical practice extracts are used as a separate cosmetic product and as an intermediate for external medicinal forms (ointments, gels, liniments and cosmetic forms. Their range is highly diverse.The aim is an overview of the scientific and technical information concerning plant  raw materials extracts using in the external drug and cosmetic products.Methods. To describe the range of extracts proposed for external use the analysis of the proposals of Russian and foreign producers submitted their official websites and online trading platforms was used. The specificity of extraction of biologically active substances of plant extracting agents: water, ethyl alcohol, glycols, vegetable oils, carbon dioxide used to obtain extracts was described on the basis of available scientific literature (eLIBRARY, PubMed, Cyberleninca, Google Books. Results. Examples of external drugs and cosmetic products based on plant raw materials extracts from a range of pharmaceutical organizations are given. It was found that from the extracting solvent used the range is presented by hydrophilic, such as glycol (propylene glycol, glycerin, water, alcoholic extracts; lipophilic (oil, CO2-extracts, and two-phase (caprylic/caprate triglyceride/water extracts. The main features of the extracting solvent used for this category of extracts: the specifics of the use in cosmetics (the skin specific effect, in particular selectivity to groups of biologically active plant substances, microbiological purity, are noted. Results of research data on the study of the prospects for the use of cosmetic ingredients – silicones, caprylic/ capric triglyceride, isopropyl myristate both solvents. The extraction techniques: classical (maceration, percolation and intensified (electro-plasma dynamic extraction, vacuum extraction circulation, CO2 supercritical extraction used in industry to produce cosmetic extracts are described

  19. The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model for topical anti-proliferative drugs

    DEFF Research Database (Denmark)

    Jensen, Mette; Groth, L.; Holmer, G.;

    2002-01-01

    The objective of this study was to establish essential fatty acid deficiency (EFAD) in hairless rats and investigate the potential of this model as a psoriasis screening model by testing the effects of calcipotriol and dithranol on differentiation and proliferation in the epidermis. Hairless rats...... were fed with a fat-free diet lacking linoleic acid. The EFAD condition was established within 8 weeks. In order to ensure that this condition had been established, several parameters were measured and observed, i.e. animal weight, water consumption, transepidermal water loss, clinical skin symptoms......, histology of the epidermis and fatty acid analysis of serum and skin. Immediately after the EFAD condition had been established, the animals were treated with dithranol ointment or different concentrations of calcipotriol solution. A reduction in epidermal thickness of 15-20% was seen after the treatment...

  20. An irresponsible biography of the actor Laurence Harvey: motion pictures, white wine, older women & long thin cigarettes

    OpenAIRE

    Brannon, Matthew

    2015-01-01

    Tiré du site Internet de Onestar Press: "Pocket edition of Laurence Harvey's "irresponsible" biography by Matthew Brannon. From the back cover of the book : Call yourself an actor ? You're not even a bad actor. You can't act at all, you fucking stupid hopeless sniveling little cunt-faced cunty fucking shit-faced arse-hole ... LAURENCE OLIVIER to Laurence Havery from Robert Stephen's "Knight errant : memoirs of a vagabond actor", Hodder and Stoughton, 1995.".

  1. APT accelerator. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, G.; Rusthoi, D. [comp.] [ed.

    1995-03-01

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation`s stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century.

  2. Topics in soliton theory

    CERN Document Server

    Carroll, RW

    1991-01-01

    When soliton theory, based on water waves, plasmas, fiber optics etc., was developing in the 1960-1970 era it seemed that perhaps KdV (and a few other equations) were really rather special in the set of all interesting partial differential equations. As it turns out, although integrable systems are still special, the mathematical interaction of integrable systems theory with virtually all branches of mathematics (and with many currently developing areas of theoretical physics) illustrates the importance of this area. This book concentrates on developing the theme of the tau function. KdV and K

  3. Quantum mechanics selected topics

    CERN Document Server

    Perelomov, Askold Mikhailovich

    1998-01-01

    It can serve as a good supplement to any quantum mechanics textbook, filling the gap between standard textbooks and higher-level books on the one hand and journal articles on the other. This book provides a detailed treatment of the scattering theory, multidimensional quasi-classical approximation, non-stationary problems for oscillators and the theory of unstable particles. It will be useful for postgraduate students and researchers who wish to find new, interesting information hidden in the depths of non-relativistic quantum mechanics.

  4. Automated Word Puzzle Generation via Topic Dictionaries

    CERN Document Server

    Pinter, Balazs; Szabo, Zoltan; Lorincz, Andras

    2012-01-01

    We propose a general method for automated word puzzle generation. Contrary to previous approaches in this novel field, the presented method does not rely on highly structured datasets obtained with serious human annotation effort: it only needs an unstructured and unannotated corpus (i.e., document collection) as input. The method builds upon two additional pillars: (i) a topic model, which induces a topic dictionary from the input corpus (examples include e.g., latent semantic analysis, group-structured dictionaries or latent Dirichlet allocation), and (ii) a semantic similarity measure of word pairs. Our method can (i) generate automatically a large number of proper word puzzles of different types, including the odd one out, choose the related word and separate the topics puzzle. (ii) It can easily create domain-specific puzzles by replacing the corpus component. (iii) It is also capable of automatically generating puzzles with parameterizable levels of difficulty suitable for, e.g., beginners or intermedia...

  5. Topics in Metric Approximation

    Science.gov (United States)

    Leeb, William Edward

    This thesis develops effective approximations of certain metrics that occur frequently in pure and applied mathematics. We show that distances that often arise in applications, such as the Earth Mover's Distance between two probability measures, can be approximated by easily computed formulas for a wide variety of ground distances. We develop simple and easily computed characterizations both of norms measuring a function's regularity -- such as the Lipschitz norm -- and of their duals. We are particularly concerned with the tensor product of metric spaces, where the natural notion of regularity is not the Lipschitz condition but the mixed Lipschitz condition. A theme that runs throughout this thesis is that snowflake metrics (metrics raised to a power less than 1) are often better-behaved than ordinary metrics. For example, we show that snowflake metrics on finite spaces can be approximated by the average of tree metrics with a distortion bounded by intrinsic geometric characteristics of the space and not the number of points. Many of the metrics for which we characterize the Lipschitz space and its dual are snowflake metrics. We also present applications of the characterization of certain regularity norms to the problem of recovering a matrix that has been corrupted by noise. We are able to achieve an optimal rate of recovery for certain families of matrices by exploiting the relationship between mixed-variable regularity conditions and the decay of a function's coefficients in a certain orthonormal basis.

  6. Illustrative EDOF topics in Fourier optics

    Science.gov (United States)

    George, Nicholas; Chen, Xi; Chi, Wanli

    2011-10-01

    In this talk we present a series of illustrative topics in Fourier Optics that are proving valuable in the design of EDOF camera systems. They are at the level of final examination problems that have been made solvable by a student or professoi having studied from one of Joseph W. Goodman's books---our tribute for his 75fr year. As time permits, four illustrative topics are l) Electromagnetic waves and Fourier optics;2) The perfect lens; 3) Connection between phase delay and radially varying focal length in an asphere and 4) tailored EDOF designs.

  7. Topic Time Series Analysis of Microblogs

    Science.gov (United States)

    2014-10-01

    does not display a currently valid OMB control number. 1. REPORT DATE OCT 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE...Tweets in topic k triggered by a Tweet in topic k, also known as the branching factor. ωk is a parameter controlling the rate of decay, i.e. how...2011. [20] Yosihiko Ogata . Statistical models for earthquake occurrences and residual analysis for point pro- cesses. Journal of the American

  8. Heart block following topical latanoprost treatment

    Science.gov (United States)

    De Smit, Elisabeth; Theodorou, Maria; Hildebrand, Göran Darius; Bloom, Philip

    2011-01-01

    The authors report a case of second degree heart block associated with topical latanoprost treatment. The authors discuss the possibility of a causative effect as the cessation of this treatment resulted in improvement of the arrhythmia. The authors highlight previous reports and research in humans and animals which demonstrate an association of arrhythmias with prostaglandin analogues. This report draws attention to the possibility that an extremely commonly prescribed topical drug may trigger arrhythmias in susceptible individuals. It is important that prescribers are aware of this possible side-effect. PMID:22679164

  9. Topics in quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Lamon, Raphael

    2010-06-29

    Quantum gravity is an attempt to unify general relativity with quantum mechanics which are the two highly successful fundamental theories of theoretical physics. The main difficulty in this unification arises from the fact that, while general relativity describes gravity as a macroscopic geometrical theory, quantum mechanics explains microscopic phenomena. As a further complication, not only do both theories describe different scales but also their philosophical ramifications and the mathematics used to describe them differ in a dramatic way. Consequently, one possible starting point of an attempt at a unification is quantum mechanics, i.e. particle physics, and try to incorporate gravitation. This pathway has been chosen by particle physicists which led to string theory. On the other hand, loop quantum gravity (LQG) chooses the other possibility, i.e. it takes the geometrical aspects of gravity seriously and quantizes geometry. The first part of this thesis deals with a generalization of loop quantum cosmology (LQC) to toroidal topologies. LQC is a quantization of homogenous solutions of Einstein's field equations using tools from LQG. First the general concepts of closed topologies is introduced with special emphasis on Thurston's theorem and its consequences. It is shown that new degrees of freedom called Teichmueller parameters come into play and their dynamics can be described by a Hamiltonian. Several numerical solutions for a toroidal universe are presented and discussed. Following the guidelines of LQG this dynamics are rewritten using the Ashtekar variables and numerical solutions are shown. However, in order to find a suitable Hilbert space a canonical transformation must be performed. On the other hand this transformation makes the quantization of geometrical quantities less tractable such that two different ways are presented. It is shown that in both cases the spectrum of such geometrical operators depends on the initial value problem

  10. 浅谈《史记·龟策列传》——兼与《庄子》之《外物》等篇的比较%Discussion on Turtle Biographies in Historical Records, Comparing with the Objects and Other Articles in Chuang-tzu

    Institute of Scientific and Technical Information of China (English)

    刘洪生

    2016-01-01

    according to the basic ideas about the Turtle Biographies, in Records of the Historian, Sima Qian' s Preface, Mr. Chu said about its modern version,"The first and the last part of Oracle' s records should be the original of Sima Qian and it is also all contents of the biography. The ancient historians think it is no recorded book or improper to be sorted in biographies, which is worth discussing. Mr. Chu' s words are the complete misunderstanding of the uniqueness of the biography, which leads to the later historian' s criticism;at the same time, as to Chu Shaosun' s so-called complements it is undeniable about its certain literary and historical value, which is the re-creation of the text and historical biography of Chuang Tzu. Mr. Chu' s remarks crossed with several texts of Chuang Tzu shows that the doctrine of the pre-Qin presents the quality of history; history and biography literature is the product of the historiographer' s culture, and pre-Qin philosophers are also originated from the official and the relationship between those two.%按《史记·太史公自序》关于《龟策列传》的基本构想,今本《史记·龟策列传》"褚先生曰"之前的第一部分和最后的"卜辞"记录,应该就是司马迁的原作和该篇传记的全部内容. 旧史家认为其"有录无书"或不当入于"列传"之体,是值得商榷的. 而"褚先生曰"完全是作者不领会该篇传记的独特性所致,也招致了后世史论家的一致诟病;同时,也不可否认,所谓褚少孙补作,仍有一定文献性和史料性价值,是对《庄子》文本和有关历史传说的再创作. "褚先生曰"之所以杂凑《庄子》多篇,也说明先秦诸子之书,与"史"有同质的关系;史传文学是史官文化的产物,先秦诸子亦源于史官,二者的关系是同源而生.

  11. Topics in Theoretical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Andrew [Boston Univ., MA (United States); Schmaltz, Martin [Boston Univ., MA (United States); Katz, Emmanuel [Boston Univ., MA (United States); Rebbi, Claudio [Boston Univ., MA (United States); Glashow, Sheldon [Boston Univ., MA (United States); Brower, Richard [Boston Univ., MA (United States); Pi, So-Young [Boston Univ., MA (United States)

    2016-09-30

    This award supported a broadly based research effort in theoretical particle physics, including research aimed at uncovering the laws of nature at short (subatomic) and long (cosmological) distances. These theoretical developments apply to experiments in laboratories such as CERN, the facility that operates the Large Hadron Collider outside Geneva, as well as to cosmological investigations done using telescopes and satellites. The results reported here apply to physics beyond the so-called Standard Model of particle physics; physics of high energy collisions such as those observed at the Large Hadron Collider; theoretical and mathematical tools and frameworks for describing the laws of nature at short distances; cosmology and astrophysics; and analytic and computational methods to solve theories of short distance physics. Some specific research accomplishments include + Theories of the electroweak interactions, the forces that give rise to many forms of radioactive decay; + Physics of the recently discovered Higgs boson. + Models and phenomenology of dark matter, the mysterious component of the universe, that has so far been detected only by its gravitational effects. + High energy particles in astrophysics and cosmology. + Algorithmic research and Computational methods for physics of and beyond the Standard Model. + Theory and applications of relativity and its possible limitations. + Topological effects in field theory and cosmology. + Conformally invariant systems and AdS/CFT. This award also supported significant training of students and postdoctoral fellows to lead the research effort in particle theory for the coming decades. These students and fellows worked closely with other members of the group as well as theoretical and experimental colleagues throughout the physics community. Many of the research projects funded by this grant arose in response to recently obtained experimental results in the areas of particle physics and cosmology. We describe a few of

  12. Corticosteróide tópico oclusivo no tratamento de manifestações gengivais de doenças vesicobolhosas auto-imunes Topical occlusive corticosteroid for the treatment of gingival manifestations of vesicobullous autoimmune diseases

    Directory of Open Access Journals (Sweden)

    Ana Carolina Fragoso Motta

    2006-06-01

    Full Text Available O tratamento das lesões gengivais de doenças vesicobolhosas auto-imunes constitui grande desafio na estomatologia, principalmente pela natureza crônica das lesões. O tratamento sistêmico é necessário no controle das apresentações mais graves; entretanto, quando possível, o tratamento tópico é preferível. Este artigo descreve uma técnica oclusiva para aplicação de corticosteróide tópico que tem demonstrado ser eficaz no controle dessas lesões, sobretudo em pacientes com manifestações exclusivamente gengivais.Management of gingival lesions of vesicobullous autoimmune diseases is one the main challenges to oral medicine, primarily because of their chronic nature. Systemic therapy is required in most severe lesions, however, whenever feasible, topic corticosteroid therapy is preferred. This article describes a technique to provide topical occlusive corticotherapy that has shown to be effective in controlling these lesions, especially in patients exclusively with gingival lesions.

  13. Organic solvent topical report

    Energy Technology Data Exchange (ETDEWEB)

    COWLEY, W.L.

    1999-05-13

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an organic solvent fire is within risk evaluation guidelines. This report updates information contained in Analysis of Consequences of Postulated Solvent Fires in Hanford Site Waste Tanks. WHC-SD-WM-CN-032. Rev. 0A (Cowley et al. 1996). However, this document will not replace Cowley et al (1996) as the primary reference for the Basis for Interim Operation (BIO) until the recently submitted BIO amendment (Hanson 1999) is approved by the US Department of Energy. This conclusion depends on the use of controls for preventing vehicle fuel fires and for limiting the use of flame cutting in areas where hot metal can fall on the waste surface.The required controls are given in the Tank Waste Remediation System Technical Safety Requirements (Noorani 1997b). This is a significant change from the conclusions presented in Revision 0 of this report. Revision 0 of this calcnote concluded that some organic solvent fire scenarios exceeded risk evaluation guidelines, even with controls imposed.

  14. Topics on electricity trade

    Energy Technology Data Exchange (ETDEWEB)

    Skytte, K.

    2001-07-01

    being unable to fulfil the commitments made on the spot market. The disclosed cost of using the regulating power market is a quadratic function of the amount of regulation. This asymmetric cost may encourage bidders with fluctuating production to be more strategic in their way of bidding on the spot market. By using such strategies the extra costs (for e.g. wind power) needed to counter unpredictable fluctuations may be limited. The fourth paper applies the findings in the previous paper to show how a supplier with a 'controllable' production will make strategic bids on the power exchange - in this case a heat pump. The fifth paper discusses the design of the regulating power market and what the choice of design means for suppliers with fluctuating production, e.g. wind turbines. It is found that not only does the accuracy of the wind prediction influence the use of the power exchange, but the structure of the power exchange itself may also play an important role. Several studies of the northern European electricity liberalisation have concluded that developments of a liberalised electricity market and cross border trade can be of benefit for the consumers and bring along a global environmental improvement. All these studies have assumed that a perfect competitive electricity market can be obtained. A number of imperfections, which inevitably will arise, have not been taken into account, - at least in the transition period. These imperfections can be technical, economic or tradition-bound, but may have political characteristics as well. The sixth paper in this thesis surveys those market imperfections which are most likely to appear. Market imperfections can, for example, have structural or political characteristics that imply non-optimal competitive behaviour, e.g., the means to achieve political goals may hinder the desirable effects of the liberalisation. This can, for example, come from the creation of suitable arrangements for survival and enlargement of

  15. Mapping the evolution of research topics using ATM and SNA

    Institute of Scientific and Technical Information of China (English)

    Chunlei; YE

    2014-01-01

    Purpose:This paper introduces an analysis framework for tracking the evolution of research topics at the selected topics level,covering a research topic’s evolution trend,evolution path and its content changes over time.Design/methodology/approach:After the topics were recovered by the author-topic model,we first built the keyword-topic co-occurrence network to track the dynamics of topic trends.Then a single-mode network was constructed with each node representing a topic and edge indicating the relationship between topics.It was used to illustrate the evolution path and content changes of research topics.A case study was conducted on the digital library research in China to verify the effectiveness of the analysis framework.Findings:The experimental results show that this analysis framework can be used to track evolution of research topics at a micro level and using social network analysis method can help understand research topics’evolution paths and content changes with the passage of time.Research limitations:Using the analysis framework will produce limited results when examining unstructured data such as social media data.In addition,the effectiveness of the framework introduced in this paper needs to be verified with more research topics in information science and in more scientific fields.Practical implications:This analysis framework can help scholars and researchers map research topics’evolution process and gain insights into how a field’s topics have evolved over time.Originality/value:Tbe analysis framework used in this study can help reveal more micro evolution details.The index to measure topic association strength defined in this paper reflects both similarity and dissimilarity between topics,which belps better understand research topics’evolution paths and content changes.

  16. Topics on electricity trade

    Energy Technology Data Exchange (ETDEWEB)

    Skytte, K.

    2001-07-01

    being unable to fulfil the commitments made on the spot market. The disclosed cost of using the regulating power market is a quadratic function of the amount of regulation. This asymmetric cost may encourage bidders with fluctuating production to be more strategic in their way of bidding on the spot market. By using such strategies the extra costs (for e.g. wind power) needed to counter unpredictable fluctuations may be limited. The fourth paper applies the findings in the previous paper to show how a supplier with a 'controllable' production will make strategic bids on the power exchange - in this case a heat pump. The fifth paper discusses the design of the regulating power market and what the choice of design means for suppliers with fluctuating production, e.g. wind turbines. It is found that not only does the accuracy of the wind prediction influence the use of the power exchange, but the structure of the power exchange itself may also play an important role. Several studies of the northern European electricity liberalisation have concluded that developments of a liberalised electricity market and cross border trade can be of benefit for the consumers and bring along a global environmental improvement. All these studies have assumed that a perfect competitive electricity market can be obtained. A number of imperfections, which inevitably will arise, have not been taken into account, - at least in the transition period. These imperfections can be technical, economic or tradition-bound, but may have political characteristics as well. The sixth paper in this thesis surveys those market imperfections which are most likely to appear. Market imperfections can, for example, have structural or political characteristics that imply non-optimal competitive behaviour, e.g., the means to achieve political goals may hinder the desirable effects of the liberalisation. This can, for example, come from the creation of suitable arrangements for survival and enlargement of

  17. Seven topics in functional magnetic resonance imaging.

    Science.gov (United States)

    Bandettini, Peter A

    2009-09-01

    Functional MRI (fMRI) is a non-invasive brain imaging methodology that started in 1991 and allows human brain activation to be imaged at high resolution within only a few minutes. Because it has extremely high sensitivity, is relatively easy to implement, and can be performed on most standard clinical MRI scanners. It continues to grow at an explosive rate throughout the world. Over the years, at any given time, fMRI has been defined by only a handful of major topics that have been the focus of researchers using and developing the methodology. In this review, I attempt to take a snapshot of the field of fMRI as it is in mid-2009 by discussing the seven topics that I feel are most on the minds of fMRI researchers. The topics are, in no particular order or grouping: (1) Clinical impact, (2) Utilization of individual functional maps, (3) fMRI signal interpretation, (4) Pattern effect mapping and decoding, (5) Endogenous oscillations, (6) MRI technology, and (7) Alternative functional contrast mechanisms. Most of these topics are highly interdependent, each advancing as the others advance. While most fMRI involves applications towards clinical or neuroscience questions, all applications are fundamentally dependent on advances in basic methodology as well as advances in our understanding of the relationship between neuronal activity and fMRI signal changes. This review neglects almost completely an in-depth discussion of applications. Rather the discussions are on the methods and interpretation.

  18. Selecting a Topic in Public Speaking

    Institute of Scientific and Technical Information of China (English)

    刘玉霞

    2013-01-01

    The first step in speechmaking is choosing a topic, which will decide the success of the speech. In the paper, we are go⁃ing to discuss how to select a topic in public speaking, and we’ll mainly talk about the following: the speaker, the occasion and the audience, selecting a topic, specific methods for choosing a topic and available topics.

  19. Intelligent topical sentiment analysis for the classification of e-learners and their topics of interest.

    Science.gov (United States)

    Ravichandran, M; Kulanthaivel, G; Chellatamilan, T

    2015-01-01

    Every day, huge numbers of instant tweets (messages) are published on Twitter as it is one of the massive social media for e-learners interactions. The options regarding various interesting topics to be studied are discussed among the learners and teachers through the capture of ideal sources in Twitter. The common sentiment behavior towards these topics is received through the massive number of instant messages about them. In this paper, rather than using the opinion polarity of each message relevant to the topic, authors focus on sentence level opinion classification upon using the unsupervised algorithm named bigram item response theory (BIRT). It differs from the traditional classification and document level classification algorithm. The investigation illustrated in this paper is of threefold which are listed as follows: (1) lexicon based sentiment polarity of tweet messages; (2) the bigram cooccurrence relationship using naïve Bayesian; (3) the bigram item response theory (BIRT) on various topics. It has been proposed that a model using item response theory is constructed for topical classification inference. The performance has been improved remarkably using this bigram item response theory when compared with other supervised algorithms. The experiment has been conducted on a real life dataset containing different set of tweets and topics.

  20. Intelligent Topical Sentiment Analysis for the Classification of E-Learners and Their Topics of Interest

    Directory of Open Access Journals (Sweden)

    M. Ravichandran

    2015-01-01

    Full Text Available Every day, huge numbers of instant tweets (messages are published on Twitter as it is one of the massive social media for e-learners interactions. The options regarding various interesting topics to be studied are discussed among the learners and teachers through the capture of ideal sources in Twitter. The common sentiment behavior towards these topics is received through the massive number of instant messages about them. In this paper, rather than using the opinion polarity of each message relevant to the topic, authors focus on sentence level opinion classification upon using the unsupervised algorithm named bigram item response theory (BIRT. It differs from the traditional classification and document level classification algorithm. The investigation illustrated in this paper is of threefold which are listed as follows: (1 lexicon based sentiment polarity of tweet messages; (2 the bigram cooccurrence relationship using naïve Bayesian; (3 the bigram item response theory (BIRT on various topics. It has been proposed that a model using item response theory is constructed for topical classification inference. The performance has been improved remarkably using this bigram item response theory when compared with other supervised algorithms. The experiment has been conducted on a real life dataset containing different set of tweets and topics.

  1. Topical agents in burn care

    Directory of Open Access Journals (Sweden)

    Momčilović Dragan

    2002-01-01

    Full Text Available Introduction Understanding of fluid shifts and recognition of the importance of early and appropriate fluid replacement therapy have significantly reduced mortality in the early post burn period. After the bum patient successfully passes the resuscitation period, the burn wound represents the greatest threat to survival. History Since the dawn of civilization, man has been trying to find an agent which would help burn wounds heal, and at the same time, not harm general condition of the injured. It was not until the XX century, after the discovery of antibiotics, when this condition was fulfilled. In 1968, combining silver and sulfadiazine, fox made silver-sulfadiazine, which is a 1% hydro-soluble cream and a superior agent in topical treatment of burns today. Current topical agents None of the topical antimicrobial agents available today, alone or combined, have the characteristics of ideal prophylactic agents, but they eliminate colonization of burn wound, and invasive infections are infrequent. With an excellent spectrum of activity, low toxicity, and ease of application with minimal pain, silver-sulfadiazine is still the most frequently used topical agent. Conclusion The incidence of invasive infections and overall mortality have been significantly reduced after introduction of topical burn wound antimicrobial agents into practice. In most burn patients the drug of choice for prophylaxis is silver sulfadiazine. Other agents may be useful in certain clinical situations.

  2. Selected topics of fluid mechanics

    Science.gov (United States)

    Kindsvater, Carl E.

    1958-01-01

    the Euler, Froude, Reynolds, Weber, and Cauchy numbers are defined as essential tools for interpreting and using experimental data. The derivations of the energy and momentum equations are treated in detail. One-dimensional equations for steady nonuniform flow are developed, and the restrictions applicable to the equations are emphasized. Conditions of uniform and gradually varied flow are discussed, and the origin of the Chezy equation is examined in relation to both the energy and the momentum equations. The inadequacy of all uniform-flow equations as a means of describing gradually varied flow is explained. Thus, one of the definitive problems of river hydraulics is analyzed in the light of present knowledge. This report is the outgrowth of a series of short schools conducted during the spring and summer of 1953 for engineers of the Surface Water Branch, Water Resources Division, U. S. Geological Survey. The topics considered are essentially the same as the topics selected for inclusion in the schools. However, in order that they might serve better as a guide and outline for informal study, the arrangement of the writer's original lecture notes has been considerably altered. The purpose of the report, like the purpose of the schools which inspired it, is to build a simple but strong framework of the fundamentals of fluid mechanics. It is believed that this framework is capable of supporting a detailed analysis of most of the practical problems met by the engineers of the Geological Survey. It is hoped that the least accomplishment of this work will be to inspire the reader with the confidence and desire to read more of the recent and current technical literature of modern fluid mechanics.

  3. Biography of literary art. An attempt at a literary project of Tadeusz Kantor

    Directory of Open Access Journals (Sweden)

    Irena Górska

    2009-01-01

    Full Text Available In universal consciousness, Tadeusz Kantor is an artist of theatre, painter, creator in other fine arts, but also author of a great number of writings on aesthetics, manifestos, sketches, essays, notes from rehearsals, dramatic scores and of some poems. What is characteristic is that various forms of writing, which by assumption are a theoretical expression of Kantor's ideas on theatre or fine arts, at the same time obtain a character of a literary work while his verses direct one towards theory. Painting, theatre and ideas connected with them are supplemented in the act of writing, which becomes a necessity for Kantor. The author of Dead Class changes the theatrical project into a literary project and in his writing he intermingles drama, commentary, theatre, his own theoretical and biographical reflections, observations of a masterpiece and states of his own consciousness. He plays theatrical ideas not only on the stage but also in theoretical texts and in verses. It is just in writing that the artist from Wielopole establishes anew the relations between theatre, literature and his own biography.

  4. Balancing Biography and Institutional History: Eric Worrell’s Australian Reptile Park

    Directory of Open Access Journals (Sweden)

    Nancy Cushing

    2009-11-01

    Full Text Available When a young naturalist opened his new wildlife park at Wyoming on the NSW Central Coast in the late 1950s, he gave it his own name: Eric Worrell’s Australian Reptile Park. Through the park, Worrell made a significant contribution to environmental education, the development of knowledge of captive animal care and display and the provision of antivenoms for the bites of a range of dangerous creatures. More than this, it was the geographic and emotional centre of Worrell’s world: the fulfilment of a childhood dream, a home for his family and a site for forming new personal and professional relationships. In preparation for the jubilee of the park, its history is being written by two academics from the University of Newcastle. An attractive means of creating the necessary narrative structure and human interest to ensure the wide appeal of this history is to follow Worrell’s lead and place his life at the centre of this institutional history. This is the direction suggested by the written sources on the park and it is accentuated by many of our oral informants who organise their memories of the park around Worrell. To what extent can an institutional history be a biography of the person at the heart of that institution? Is it possible to disentangle the life from the institution? This article offers some preliminary answers to these questions through a case study of the writing of a history of Eric Worrell’s Australian Reptile Park.

  5. [Historical origin of Jiu Tangshu·biography of Sun Simiao].

    Science.gov (United States)

    Song, Zhen-Min

    2012-09-01

    The book Datang Xinyu·Sun Simiao was compiled by Liu Su according to the original national historical papers of the Tang Dynasty which basically kept the features of national history. Based on this book and Binglishufu Xu (written by Lu Zhaolin) and Tanbinlu·Sun Simiao, Zhang Du sorted out the data about Sun Simiao and compiled the book Xuanshizhi·Sun Simiao (in which the three stories of his lifetime were made up). Jiu Tangshi·Sun Simiao was edited by historiographers in the Hou-Jin Dynasty according to the biography of Sun Simiao in Tang national history, and referring to the Datang Xinyu·Sun Simiao, Xuanshizhi·Sun Simiao, in which they only made a few adjustments on the basis of Xuanshizhi. Du Guangting compiled Xianzhuan Shiyi·Sun Simiao and Xuanshizhi·Sun Simiao and added three stories of gods and spirits about Sun Simiao after he became immortal. Taipingguangji of the North Song Dynasty was compiled according to Xianzhuan Shiyi·Sun Simiao and Xuanshizhi·Sun Simiao.

  6. topicmodels: An R Package for Fitting Topic Models

    Directory of Open Access Journals (Sweden)

    Bettina Grun

    2011-05-01

    Full Text Available Topic models allow the probabilistic modeling of term frequency occurrences in documents. The fitted model can be used to estimate the similarity between documents as well as between a set of specified keywords using an additional layer of latent variables which are referred to as topics. The R package topicmodels provides basic infrastructure for fitting topic models based on data structures from the text mining package tm. The package includes interfaces to two algorithms for fitting topic models: the variational expectation-maximization algorithm provided by David M. Blei and co-authors and an algorithm using Gibbs sampling by Xuan-Hieu Phan and co-authors.

  7. Quantum mechanics II advanced topics

    CERN Document Server

    Rajasekar, S

    2015-01-01

    Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

  8. Tracking Multiple Topics for Finding Interesting Articles

    Energy Technology Data Exchange (ETDEWEB)

    Pon, R K; Cardenas, A F; Buttler, D J; Critchlow, T J

    2007-02-15

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. Also by relating a topic's interestingness to an article's interestingness, iScore is able to achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 9% to 14% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.

  9. Orienting to Topic in Clinical Discourse Elicitation of Everyday Conversation

    Science.gov (United States)

    Fond, Marissa Joanne

    2013-01-01

    Talking topically, as it is understood intuitively and evoked metadiscursively, requires constructing an intersubjective orientation to talk that must be continually renewed. Analysis of interactants' ability to orient to topic emergence provides evidence of what is achieved in interaction, as well as why conversational coordination can lapse…

  10. The Research Summary of Biographies of Merchants in Historical Records in the Last Ten Years%《史记·货殖列传》近十年研究综述

    Institute of Scientific and Technical Information of China (English)

    路萌莉

    2014-01-01

    《货殖列传》是《史记》中很重要的一篇人物类传,近十年来,对它的研究论述颇多,研究角度也是多层次的,主要体现在经济、地理、人物、文学性、文字考证等方面。但在成果颇丰的同时,也存在一些问题,需要引起重视,如研究内容的重复、论证角度出现偏差、参考文献不足等问题。%Biographies of Merchants in Historical Records is the most important biography about people. Last decade, more and more articles are written to study it from the multi-perspective views, such as economy, geography, figures, literal analysis and wording. But it still has many problems, such as the duplicate content, the wrong views and unknown documents.

  11. Ancestors as Icons: The Lives of Hebrew Saints in Eusebius’ Praeparatio Evangelica

    Directory of Open Access Journals (Sweden)

    Aaron P. Johnson

    2010-11-01

    Full Text Available In his biographies of the Old Testament holy men, Eusebius applies the topos of the rivalry between verbal and visual portraits, but goes beyond his classical precedents by treating lives as moral icons.

  12. Seven topics in perturbative QCD

    Energy Technology Data Exchange (ETDEWEB)

    Buras, A.J.

    1980-09-01

    The following topics of perturbative QCD are discussed: (1) deep inelastic scattering; (2) higher order corrections to e/sup +/e/sup -/ annihilation, to photon structure functions and to quarkonia decays; (3) higher order corrections to fragmentation functions and to various semi-inclusive processes; (4) higher twist contributions; (5) exclusive processes; (6) transverse momentum effects; (7) jet and photon physics.

  13. Topics in combinatorial pattern matching

    DEFF Research Database (Denmark)

    Vildhøj, Hjalte Wedel

    This dissertation studies problems in the general theme of combinatorial pattern matching. More specifically, we study the following topics: Longest Common Extensions. We revisit the longest common extension (LCE) problem, that is, preprocess a string T into a compact data structure that supports...

  14. Topic Maps: Adopting User-Centred Indexing Technologies in Course Management Systems

    Science.gov (United States)

    Venkatesh, Vivek; Shaw, Steven; Dicks, Dennis; Lowerison, Gretchen; Zhang, Dai; Sanjakdar, Roukana

    2007-01-01

    This article provides an empirical evaluation of an indexing technology, topic maps (ISO 13250), in the context of an academic task in a higher education context. Topic maps are a form of indexing that define and display the interrelationships between various topics in a given domain, as well as anchor these topics to specific resources that help…

  15. Rosacea-like eruption due to topical pimecrolimus.

    Science.gov (United States)

    El-Heis, S; Buckley, D A

    2015-05-18

    Topical calcineurin inhibitors have been used outside their approved indications for a number of conditions, including topical steroid-induced rosacea. However, tacrolimus ointment itself has been reported to trigger rosacea in a small number of cases. We report a case of a rosacea-like eruption in a 39-year-old woman occurring after the use of pimecrolimus cream for 12 months for atopic dermatitis. Withdrawal of pimecrolimus combined with treatment with oral lymecycline, topical metronidazole, and an emollient resulted in resolution of the eruption. There have been 5 previously reported cases of a topical pimecrolimus-induced rosacea-like eruption suggesting that this rare side-effect may be a class effect of all topical calcineurin inhibitors. Dermatologists prescribing these drugs should be aware of this uncommon complication and may wish to warn patients of its occurrence as a potential side-effect when using topical calcineurin inhibitors in facial skin in adults.

  16. Approach to extracting hot topics based on network traffic content

    Institute of Scientific and Technical Information of China (English)

    Yadong ZHOU; Xiaohong GUAN; Qindong SUN; Wei LI; Jing TAO

    2009-01-01

    This article presents the formal definition and description of popular topics on the Internet,analyzes the relationship between popular words and topics,and finally introduces a method that uses statistics and correlation of the popular words in traffic content and network flow characteristics as input for extracting popular topics on the Internet.Based on this,this article adapts a clustering algorithm to extract popular topics and gives formalized results.The test results show that this method has an accuracy of 16.7% in extracting popular topics on the Internet.Compared with web mining and topic detection and tracking (TDT),it can provide a more suitable data source for effective recovery of Internet public opinions.

  17. 《旧唐书·则天皇后本纪》疑义考辨%Some Textual Researches on Old Book of Tang ·Biography of Queen Zetia

    Institute of Scientific and Technical Information of China (English)

    潘晶安; 尤炜祥

    2015-01-01

    Wu Zetian was an important character in Chinese history.There are some mistakes in Old Book of Tan g ·Biography of Queen Zetian .This article attempts to do some textual researches on Biography of Queen Zetian including the omission of words,addition of sentences and misuses,etc so as to hope offer some benefit for the revision of the Old Book of Tan g ,one of the Twenty four Histories ,whose revision is being organized by the Zhonghua Publishing House.%武则天在我国历史上影响深远。然《旧唐书·则天皇后本纪》存在诸多差讹,不仅有夺字、衍文、形误等,且不少史实均有出入。在此予以考辨,以求对中华书局组织的正在修订中的“二十四史”之一———《旧唐书》有所裨益。

  18. Topic Map: An Ontology Framework for Information Retrieval

    CERN Document Server

    Kannan, Rajkumar

    2010-01-01

    The basic classification techniques for organizing information are thesauri, taxonomy and faceted classification. Topic map is relatively a new entrant to this information space. Topic map standard describes how complex relationships between abstract concepts and real world resources can be represented using XML syntax. This paper explores how topic map incorporates the traditional techniques and what are its advantages and disadvantages in several dimensions such as content management, indexing, knowledge representation, constraint specification and query languages in the context of information retrieval. The constructs of topic maps are illustrated with a use-case implemented in XTM

  19. 《史记·儒林列传》中的先秦至汉初“六艺”之学%The Research of Six Classics in historic Records o rutin Biography from the Pre-Qin Period to the Western Han Dynasty

    Institute of Scientific and Technical Information of China (English)

    冯倩

    2015-01-01

    Historical Records treat rutin Biography and Sima Qian Preface as the outline, discussing the academic development process . The academic accomplishment and profound knowledge of the background to let him have more and more comprehensive academic un-derstanding. Rulin Biography records the academic development of Six Art, researching rutin Biography is able to have a more complete understanding of ideas, while helping to understand the development of the Western Han Dynasty Confucianism.%《史记》以《儒林列传》《太史公自序》等为提纲,司马迁有意考辨学术源流、师承家法。家学传统及博览群书之便,使其较他人更有全瞻性的文化学术史观。以《儒林列传》所录“六艺”突破,能够对司马迁的学术思想有较为完整的认识,同时有助于了解西汉前期儒学的发展情况。

  20. Retapamulin: A newer topical antibiotic

    Directory of Open Access Journals (Sweden)

    D Dhingra

    2013-01-01

    Full Text Available Impetigo is a common childhood skin infection. There are reports of increasing drug resistance to the currently used topical antibiotics including fusidic acid and mupirocin. Retapamulin is a newer topical agent of pleuromutilin class approved by the Food and Drug Administration for treatment of impetigo in children and has been recently made available in the Indian market. It has been demonstrated to have low potential for the development of antibacterial resistance and a high degree of potency against poly drug resistant Gram-positive bacteria found in skin infections including Staphylococcus aureus strains. The drug is safe owing to low systemic absorption and has only minimal side-effect of local irritation at the site of application.

  1. Do scientists trace hot topics?

    Science.gov (United States)

    Wei, Tian; Li, Menghui; Wu, Chensheng; Yan, Xiao-Yong; Fan, Ying; Di, Zengru; Wu, Jinshan

    2013-01-01

    Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries, among research works regarding different number of authors, different number of affiliations and different number of references. These observations could be valuable for policy makers when deciding research funding and also for individual researchers when searching for scientific projects.

  2. Topics on nonlinear generalized functions

    CERN Document Server

    Colombeau, J F

    2011-01-01

    The aim of this paper is to give the text of a recent introduction to nonlinear generalized functions exposed in my talk in the congress gf2011, which was asked by several participants. Three representative topics were presented: two recalls "Nonlinear generalized functions and their connections with distribution theory", "Examples of applications", and a recent development: "Locally convex topologies and compactness: a functional analysis of nonlinear generalized functions".

  3. Topical Ocular Delivery of NSAIDs

    OpenAIRE

    Ahuja, Munish; Avinash S Dhake; Sharma, Surendra K; Dipak K Majumdar

    2008-01-01

    In ocular tissue, arachidonic acid is metabolized by cyclooxygenase to prostaglandins which are the most important lipid derived mediators of inflammation. Presently nonsteroidal anti-inflammatory drugs (NSAIDs) which are cyclooxygenase (COX) inhibitors are being used for the treatment of inflammatory disorders. NSAIDs used in ophthalmology, topically, are salicylic-, indole acetic-, aryl acetic-, aryl propionic- and enolic acid derivatives. NSAIDs are weak acids with pKa mostly between 3.5 a...

  4. Topic Detection in Online Chat

    Science.gov (United States)

    2009-09-01

    including the time for reviewing instruction, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the...you. “ … Of making many books there is no end, and much study is a weariness of the flesh.” Ecclesiastes 12:12 , ESV xvi THIS PAGE INTENTIONALLY...topic detection," Online Information Review , vol. 30, pp. 496–516, 2006. [2] D. Jurafsky and J. H. Martin, Speech and Language Processing : An

  5. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1983-01-01

    Probabilistic Analysis and Related Topics, Volume 3 focuses on the continuity, integrability, and differentiability of random functions, including operator theory, measure theory, and functional and numerical analysis. The selection first offers information on the qualitative theory of stochastic systems and Langevin equations with multiplicative noise. Discussions focus on phase-space evolution via direct integration, phase-space evolution, linear and nonlinear systems, linearization, and generalizations. The text then ponders on the stability theory of stochastic difference systems and Marko

  6. Stochastic Analysis and Related Topics

    CERN Document Server

    Ustunel, Ali

    1988-01-01

    The Silvri Workshop was divided into a short summer school and a working conference, producing lectures and research papers on recent developments in stochastic analysis on Wiener space. The topics treated in the lectures relate to the Malliavin calculus, the Skorohod integral and nonlinear functionals of white noise. Most of the research papers are applications of these subjects. This volume addresses researchers and graduate students in stochastic processes and theoretical physics.

  7. Hot topics from the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Glenzinski, D.; /Fermilab

    2008-01-01

    The Tevatron Run-II began in March 2001. To date, both the CDF and D0 experiments have collected 1 fb{sup -1} of data each. The results obtained from this data set were summarized at this conference in 39 parallel session presentations covering a wide range of topics. The author summarizes the most important of those results here and comments on some of the prospects for the future.

  8. Topics from the theory of numbers

    CERN Document Server

    Grosswald, Emil

    1984-01-01

    Many of the important and creative developments in modern mathematics resulted from attempts to solve questions that originate in number theory. The publication of Emil Grosswald’s classic text presents an illuminating introduction to number theory. Combining the historical developments with the analytical approach, Topics from the Theory of Numbers offers the reader a diverse range of subjects to investigate, including: * divisibility * congruences * the Riemann zeta function * Diophantine equations and Fermat’s conjecture * the theory of partitions Comprehensive in nature, Topics from the Theory of Numbers is an ideal text for advanced undergraduates and graduate students alike. "In my opinion it is excellent. It is carefully written and represents clearly a work of a scholar who loves and understands his subject. One can only wish more authors would take such pains and would be as good and honest expositors as Grosswald." — Marc Kac "This book is designed for use in a first course in number theory at...

  9. Efinaconazole topical solution, 10%: formulation development program of a new topical treatment of toenail onychomycosis.

    Science.gov (United States)

    Bhatt, V; Pillai, R

    2015-07-01

    Transungual drug delivery of antifungals is considered highly desirable to treat common nail disorders such as onychomycosis, due to localized effects, and improved adherence resulting from minimal systemic adverse events. However, the development of effective topical therapies has been hampered by poor nail penetration. An effective topical antifungal must permeate through, and under the dense keratinized nail plate to the site of infection in the nail bed and nail matrix. We present here the formulation development program to provide effective transungual and subungual delivery of efinaconazole, the first topical broad spectrum triazole specifically developed for onychomycosis treatment. We discuss the important aspects encompassing the formulation development program for efinaconazole topical solution, 10%, focusing on its solubility in a number of solvents, in vitro penetration through the nail, and in vivo efficacy. Efinaconazole topical solution, 10% is a stable, non-lacquer, antifungal with a unique combination of ingredients added to an alcohol-based formulation to provide low surface tension and good wetting properties. This low surface tension is believed to affect effective transungual delivery of efinaconazole and believed to provide a dual mode of delivery by accessing the nail bed by wicking into the space between the nail and nail plate.

  10. Berufsbiografie und Familiengründung im methodischen Korsett Occupational Biography and Family Planning in a Methodical Corset

    Directory of Open Access Journals (Sweden)

    Mechthild Veil

    2004-11-01

    Full Text Available In der Studie werden die ambivalenten Beziehungen zwischen Berufsbiografie und Familiengründung bei jungen Erwachsenen mit abgeschlossener beruflicher Ausbildung untersucht. Geschlechtsspezifische Fragestellungen spielen insofern eine Rolle, als zwischen dem Handeln und den Erwartungen von Männern und Frauen unterschieden wird. Vorherrschend sind jedoch methodische Fragen und das Ziel, Typologien zu entwickeln.The study focuses on the ambivalent relationship between occupational biography and family planning for young adults with certified occupational training. Gender-specific modes of inquiry play a role to the extent that the actions and expectations of men and women are differentiated. However, methodical questions and the goal of developing typologies are paramount.

  11. TIAGO VEIGA, A BIOGRAPHY BY MÁRIO CLÁUDIO: THE MARCH OF THE TWENTIETH CENTURY OR THE MEMORY OF CONTEMPORANEOUS PORTUGAL

    Directory of Open Access Journals (Sweden)

    Cândido Oliveira Martins

    2013-11-01

    Full Text Available Mário Cláudio’s novel, Tiago Veiga, uma biografia (2011, is a long and uni­que biography that follows the path of former biographies. Three distinct forms of memory writing can be detached here among other singularities. Firstly, there is the idea of a challenging and well aware heteronimic pro­cess that is focused in the misterious life of Tiago Veiga. Secondly, there is the biographic portrait that is constructed within the observance of the gender codes and beholds a wide scope of intertextual rememberances. Finally, this becomes a unique crytical biography of Portugal during one century, because it recreates the cosmopolitan life of an unknown character born in 1910. 

  12. A Revision on Brief Biography for a Writer Named CAI Tao in Xianyou%仙游籍文学家蔡僚小传辑补

    Institute of Scientific and Technical Information of China (English)

    李亮亮

    2012-01-01

    The History of Song Dynasty did not have a biography for CAI Tao who was one of writers in Xianyou acrossing Northem Song Dynasty and Southern Song Dynasty, while Songshi Yi gave a simple introduction about him. Other biographies for him some left gaps while some gave the wrong imformation. At present, there's not systematic research on CAI Tao's biography in academic circles. Therefore, this article makes a reversion on it.%两宋之交仙游籍文学家蔡僚,《宋史》无传;《宋史翼》其本传尚嫌简略。其他小传或有缺漏,或有讹误。目前学界对于其生平缺乏系统考证,特予考辨、辑补。

  13. Modern topics in theoretical nuclear physics

    OpenAIRE

    Jennings, B. K.; Schwenk, A.

    2005-01-01

    Over the past five years there have been profound advances in nuclear physics based on effective field theory and the renormalization group. In this brief, we summarize these advances and discuss how they impact our understanding of nuclear systems and experiments that seek to unravel their unknowns. We discuss future opportunities and focus on modern topics in low-energy nuclear physics, with special attention to the strong connections to many-body atomic and condensed matter physics, as wel...

  14. Contraception via topical application? - A review.

    Science.gov (United States)

    Schaefer, H; Stüttgen, G; Schalla, W

    1979-09-01

    The skin, generally speaking, is not an absorption organ but one of its major functions is the protection of the body against the entrance of foreign material. Under certain circumstances, however, drugs can be introduced into the skin and thereby into the body as can be seen in the topical treatment of skin diseases. Though percutaneous pharmacokinetics of steroids seem appropriate for contraception, the variability of the absorption process appears to be too high for this purpose.

  15. Topical macrolide immunomodulators: a role in the treatment of vitiligo?

    NARCIS (Netherlands)

    Tjioe, M.; Vissers, W.H.P.M.; Gerritsen, M.J.P.

    2006-01-01

    Recently, topical macrolide immunomodulators have been successfully introduced in the treatment of atopic dermatitis. With the growing interest in this new line of topical immunosuppressants, research into the efficacy of these medicines in other T-cell-mediated skin diseases, such as psoriasis, lic

  16. Comparison of topical tretinoin and betamethasone in oral lichen planus

    Directory of Open Access Journals (Sweden)

    Kar H

    1996-01-01

    Full Text Available Thirty-one patients of oral lichen planus were enrolled in this study and two groups were made. Group 1 consisting of 16 patients who applied topical tretinoin 0.05% and Group 2 comprising of 15 patients who were given topical betamethasone dipropionate 0.05%. The patients applying tretinoin showed statistically significant improvement as compared to patients applying betamethasone.

  17. Immigration, Cultural-Linguistic Diversity, and Topics in Language Disorders

    Science.gov (United States)

    Cheng, Li-Rong Lilly

    2010-01-01

    This article summarizes 4 topics contributed by the author over the last 30 years of "Topics in Language Disorders" that address the issues of immigration, migration, and refugees. The focus is on the historical perspectives on evolution of terminologies from limited English proficient to English language learner and English as a new language.…

  18. Topics in Finance Part VI--Capital Budgeting

    Science.gov (United States)

    Laux, Judy

    2011-01-01

    This series on the theory of financial management offers insight into the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts as they apply to major topics in finance. The current article investigates capital budgeting. Much literature addresses this topic, with a number of articles challenging mainstream…

  19. Topic-Focus Articulation of Isotopy

    Directory of Open Access Journals (Sweden)

    Radim Sova

    2012-09-01

    Full Text Available The paper deals with linguistic phenomena at suprasentential level. In particular, it looks into how textual analysis can be enhanced by supplementing the Parisian programme of interpretive semantics, as devised by François Rastier, namely his theory of isotopies, with elementary aspects of topic-focus articulation (TFA, as well as contextual boundness (CB and contextual non-boundness (CN, as elaborated within the Praguian linguistic tradition (V. Mathesius, P. Sgall, E. Hajičová, F. Daneš, J. Firbas, and how the descriptive power of the former can be increased by the latter. In this respect, it is argued that two types of TFA phenomena interact during any process of textual interpretation: those of topic-focus articulation at the level of sentence, conceiving lexical morphs as thematic (T and/or rhematic (R, as well as contextually bound (CB and/or contextually non-bound (CN, and those of topic-focus articulation at the level of isotopy, with each isotopy being conceived as structured around a center (an abstract semantic unit and periphery (a span of concrete utterances. Two types of such interaction are described, each defined by either correlation, or non-correlation of the CB and CN semes at the levels of isotopy and sentence, respectively: thematic-rhematic isotopy, induced by co-occurrence of the CB seme of the center and the CB seme of the periphery; and thematic-rhematic allotopy (i.e. non-isotopy, induced by co-occurrence of the CB seme of the center and the CN seme of the periphery. Since topic-focus isotopies and allotopies can be perceived as members of privative oppositions, a tentative system of such oppositions is presented, based on linguistic analyses of selected European Commission texts drafted in English and their Czech translations. The author’s ultimate intention is to show that the semantic features of topic-focus articulation at the sentential and suprasentential levels are both structurally parallel and

  20. Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy

    Directory of Open Access Journals (Sweden)

    Alexander L. Pan

    2012-01-01

    Full Text Available Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.