WorldWideScience

Sample records for biochemical platform integration

  1. National Bioenergy Center, Biochemical Platform Integration Project: Quarterly Update, Winter 2011-2012 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2012-04-01

    Winter 2011-2012 issue of the National Bioenergy Center Biochemical Platform Integration Project quarterly update. Issue topics: 34th Symposium on Biotechnology for Fuels and Chemicals; feasibility of NIR spectroscopy-based rapid feedstock reactive screening; demonstrating integrated pilot-scale biomass conversion. The Biochemical Process Integration Task focuses on integrating the processing steps in enzyme-based lignocellulose conversion technology. This project supports the U.S. Department of Energy's efforts to foster development, demonstration, and deployment of 'biochemical platform' biorefineries that economically produce ethanol or other fuels, as well as commodity sugars and a variety of other chemical products, from renewable lignocellulosic biomass.

  2. Integration of biochemical sensors into wearable biomaterial platforms

    Science.gov (United States)

    Jandhyala, Sidhartha; Walper, Scott A.; Cargill, Allison A.; Ozual, Abigail; Daniele, Michael A.

    2016-05-01

    With rapidly inflating healthcare costs, a limited supply of physicians and an alarming surge in lifestyle diseases, radical changes must be made to improve preventative medicine and ensure a sustainable healthcare system. A compelling solution is to equip the population with wearable health monitors to continuously record representative and actionable physiological data. Herein, we present a preliminary design and evaluation of a biochemical sensor node enabled by a substrate comprised of a nanocellulose thin-film that conforms to the skin and carries a printed sensor element. The nanocellulose layer ensures conformal and biocompatible contact with the skin, while a printed layer provides a high surface-area electrode. While the recognition/transduction element can be exchanged for many different sensing motifs, we utilize the general structure of an electrochemical glucose sensor.

  3. 2009 Biochemical Conversion Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program’s Biochemical Conversion platform review meeting, held on April 14-16, 2009, at the Sheraton Denver Downtown, Denver, Colorado.

  4. 2011 Biomass Program Platform Peer Review: Biochemical Conversion

    Energy Technology Data Exchange (ETDEWEB)

    Pezzullo, Leslie [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Biochemical Conversion Platform Review meeting.

  5. Integrated label-free silicon nanowire sensor arrays for (bio)chemical analysis

    NARCIS (Netherlands)

    De, Arpita; Nieuwkasteele, van Jan; Carlen, Edwin T.; Berg, van den Albert

    2013-01-01

    We present a label-free (bio)chemical analysis platform that uses all-electrical silicon nanowire sensor arrays integrated with a small volume microfluidic flow-cell for real-time (bio)chemical analysis and detection. The integrated sensing platform contains an automated multi-sample injection syste

  6. Integrated microfluidic platforms for investigating neuronal networks

    Science.gov (United States)

    Kim, Hyung Joon

    This dissertation describes the development and application of integrated microfluidics-based assay platforms to study neuronal activities in the nervous system in-vitro. The assay platforms were fabricated using soft lithography and micro/nano fabrication including microfluidics, surface patterning, and nanomaterial synthesis. The use of integrated microfluidics-based assay platform allows culturing and manipulating many types of neuronal tissues in precisely controlled microenvironment. Furthermore, they provide organized multi-cellular in-vitro model, long-term monitoring with live cell imaging, and compatibility with molecular biology techniques and electrophysiology experiment. In this dissertation, the integrated microfluidics-based assay platforms are developed for investigation of neuronal activities such as local protein synthesis, impairment of axonal transport by chemical/physical variants, growth cone path finding under chemical/physical cues, and synaptic transmission in neuronal circuit. Chapter 1 describes the motivation, objectives, and scope for developing in-vitro platform to study various neuronal activities. Chapter 2 introduces microfluidic culture platform for biochemical assay with large-scale neuronal tissues that are utilized as model system in neuroscience research. Chapter 3 focuses on the investigation of impaired axonal transport by beta-Amyloid and oxidative stress. The platform allows to control neuronal processes and to quantify mitochondrial movement in various regions of axons away from applied drugs. Chapter 4 demonstrates the development of microfluidics-based growth cone turning assay to elucidate the mechanism underlying axon guidance under soluble factors and shear flow. Using this platform, the behaviors of growth cone of mammalian neurons are verified under the gradient of inhibitory molecules and also shear flow in well-controlled manner. In Chapter 5, I combine in-vitro multicellular model with microfabricated MEA

  7. CORBA Based Information Integration Platform for CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new information integration platform for computer integrated manufacturing system(CIMS) is presented, which is based on agent and CORBA. CORBA enhances the system integration be-cause it is an industry-standard for interoperable, distributed objects across heterogeneous hardware andsoftware platform. Agent technology is used to improve intelligence of integration system. In order to im-plement the information integration platform, we use network integration server to integrate network, de-sign a generic database agent to integrate database, adopt multi-agent based architecture to integrate appli-cation, and utilize wrapper as CORBA object to integrate legacy code.

  8. Quantum photonics hybrid integration platform

    CERN Document Server

    Murray, Eoin; Meany, Thomas; Flother, Frederick F; Lee, James P; Griffiths, Jonathan P; Jones, Geb A C; Farrer, Ian; Ritchie, David A; Bennet, Anthony J; Shields, Andrew J

    2015-01-01

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to an SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO2 cladding. A tuneable Mach Zehnder modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single photon nature of the emission was veri?ed by an on-chip Hanbury Brown and Twiss measurement.

  9. Quantum photonics hybrid integration platform

    Energy Technology Data Exchange (ETDEWEB)

    Murray, E.; Floether, F. F. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Ellis, D. J. P.; Meany, T.; Bennett, A. J., E-mail: anthony.bennet@crl.toshiba.co.uk; Shields, A. J. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Lee, J. P. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Engineering Department, University of Cambridge, 9 J. J. Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A. [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2015-10-26

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO{sub 2} cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  10. Material platforms for integrated quantum photonics

    CERN Document Server

    Bogdanov, Simeon; Boltasseva, Alexandra; Shalaev, Vladimir M

    2016-01-01

    On-chip integration of quantum optical systems could be a major factor enabling photonic quantum technologies. Unlike the case of electronics, where the essential device is a transistor and the dominant material is silicon, the toolbox of elementary devices required for both classical and quantum photonic integrated circuits is vast. Therefore, many material platforms are being examined to host the future quantum photonic computers and network nodes. We discuss the pros and cons of several platforms for realizing various elementary devices, compare the current degrees of integration achieved in each platform and review several composite platform approaches.

  11. ROHDIP: Resource Oriented Heterogeneous Data Integration Platform

    Directory of Open Access Journals (Sweden)

    Wael Shehab

    2016-09-01

    Full Text Available During the last few years, the revolution of social networks such as Facebook, Twitter, and Instagram led to a daily increasing of data that are heterogeneous in their sources, data models, and platforms. Heterogeneous data sources have many forms such as the www, deep web, relational databases systems, No-SQL database systems, hierarchal data systems, semi-structured files, in which data are usually allocated on different machines (distributed and have different data models (heterogeneous. Large-scale data integration efforts demonstrate that their most valuable contribution is implementing a data integration platform that provides a uniform access to the heterogeneous data sources, as well as the different versions of data reported by the same data source over time. Furthermore, the platform must be able to integrate data from a broad range of data authoring devices and database management systems. It also should be accessible by almost types of data querying devices to ensure globally querying the integration platform from any place on earth anytime and receiving the query result in any data format. In this paper, we create a resource oriented heterogeneous data integration platform (ROHDIP that facilitates the data integration process and implements the objectives discussed above. We use the resource oriented architecture ROA to support the uniform access by most types of data querying devices from anywhere and to improve the query response time.

  12. Architectural view model for an integration platform

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2012-03-01

    Full Text Available The most common architectural view model is "4+1" by Philipe Kruchten. This model presents the views required for a full description of computer system architecture. By contrast, this model seems to be insufficient to describe architecture of integration platform. Definitely lacks the view of integrated business processes. In the serviceoriented approach, one of the basic elements is a contract. It should also be included in the description of the architecture. Moreover, very important are integration mechanisms and mediation flows that should be presented in the description of architecture. Hence the need for integrated services view, and manner of their integration on the enterprise service bus. Use case view should also be extended by stereotypes required for presenting functionality exposed for other computer systems. It is therefore proposed architectural view model “1+5” for an integration platform. This model has following architectural views: Integrated processes, Use Cases, Logical, Integrated Services, Contracts, Deployment. Furthermore, in article was presented new UML profile "UML Profile for Integration Flows". In the profile were placed stereotypes corresponding to integration patterns and mediation mechanisms. It is important, that UML activity diagram was extended and its special form was obtained to model mediation flows on integration platform. Thus was proposed a new UML diagram: mediation flows diagram.

  13. Emerging heterogeneous integrated photonic platforms on silicon

    Directory of Open Access Journals (Sweden)

    Fathpour Sasan

    2015-05-01

    Full Text Available Silicon photonics has been established as a mature and promising technology for optoelectronic integrated circuits, mostly based on the silicon-on-insulator (SOI waveguide platform. However, not all optical functionalities can be satisfactorily achieved merely based on silicon, in general, and on the SOI platform, in particular. Long-known shortcomings of silicon-based integrated photonics are optical absorption (in the telecommunication wavelengths and feasibility of electrically-injected lasers (at least at room temperature. More recently, high two-photon and free-carrier absorptions required at high optical intensities for third-order optical nonlinear effects, inherent lack of second-order optical nonlinearity, low extinction ratio of modulators based on the free-carrier plasma effect, and the loss of the buried oxide layer of the SOI waveguides at mid-infrared wavelengths have been recognized as other shortcomings. Accordingly, several novel waveguide platforms have been developing to address these shortcomings of the SOI platform. Most of these emerging platforms are based on heterogeneous integration of other material systems on silicon substrates, and in some cases silicon is integrated on other substrates. Germanium and its binary alloys with silicon, III–V compound semiconductors, silicon nitride, tantalum pentoxide and other high-index dielectric or glass materials, as well as lithium niobate are some of the materials heterogeneously integrated on silicon substrates. The materials are typically integrated by a variety of epitaxial growth, bonding, ion implantation and slicing, etch back, spin-on-glass or other techniques. These wide range of efforts are reviewed here holistically to stress that there is no pure silicon or even group IV photonics per se. Rather, the future of the field of integrated photonics appears to be one of heterogenization, where a variety of different materials and waveguide platforms will be used for

  14. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  15. Hybrid Integrated Platforms for Silicon Photonics

    Directory of Open Access Journals (Sweden)

    John E. Bowers

    2010-03-01

    Full Text Available A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

  16. Integrated label-free silicon nanowire sensor arrays for (bio)chemical analysis.

    Science.gov (United States)

    De, Arpita; van Nieuwkasteele, Jan; Carlen, Edwin T; van den Berg, Albert

    2013-06-07

    We present a label-free (bio)chemical analysis platform that uses all-electrical silicon nanowire sensor arrays integrated with a small volume microfluidic flow-cell for real-time (bio)chemical analysis and detection. The integrated sensing platform contains an automated multi-sample injection system that eliminates erroneous sensor responses from sample switching due to flow rate fluctuations and provides precise sample volumes down to 10 nl. Biochemical sensing is demonstrated with real-time 15-mer DNA-PNA (peptide nucleic acid) duplex hybridization measurements from different sample concentrations in a low ionic strength, and the equilibrium dissociation constant KD ≈ 140 nM has been extracted from the experimental data using the first order Langmuir binding model. Chemical sensing is demonstrated with pH measurements from different injected samples in flow that have sensitivities consistent with the gate-oxide materials. A differential sensor measurement configuration results in a 30× reduction in sensor drift. The integrated label-free analysis platform is suitable for a wide range of small volume chemical and biochemical analyses.

  17. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  18. Hybrid Photonic Integration on a Polymer Platform

    Directory of Open Access Journals (Sweden)

    Ziyang Zhang

    2015-09-01

    Full Text Available To fulfill the functionality demands from the fast developing optical networks, a hybrid integration approach allows for combining the advantages of various material platforms. We have established a polymer-based hybrid integration platform (polyboard, which provides flexible optical input/ouptut interfaces (I/Os that allow robust coupling of indium phosphide (InP-based active components, passive insertion of thin-film-based optical elements, and on-chip attachment of optical fibers. This work reviews the recent progress of our polyboard platform. On the fundamental level, multi-core waveguides and polymer/silicon nitride heterogeneous waveguides have been fabricated, broadening device design possibilities and enabling 3D photonic integration. Furthermore, 40-channel optical line terminals and compact, bi-directional optical network units have been developed as highly functional, low-cost devices for the wavelength division multiplexed passive optical network. On a larger scale, thermo-optic elements, thin-film elements and an InP gain chip have been integrated on the polyboard to realize a colorless, dual-polarization optical 90° hybrid as the frontend of a coherent receiver. For high-end applications, a wavelength tunable 100Gbaud transmitter module has been demonstrated, manifesting the joint contribution from the polyboard technology, high speed polymer electro-optic modulator, InP driver electronics and ceramic electronic interconnects.

  19. Biochemical composition of zooplankton of Bombay High (oil platform) area in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Bhat, K.L.; Wagh, A.B.

    Variations in the biochemical constituents and calorific values of zooplankton from an off-shore oil processing platform were estimated. Mean value of biomass was 0.35 ml.m/3 with relatively higher values during post-monsoon period. Copepods formed...

  20. Biomass Program 2007 Program Peer Review - Biochemical and Products Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Biochemical and Products Platform Review held on August 7-9, 2007 in Denver, Colorado.

  1. Integrated platform and API for electrophysiological data.

    Science.gov (United States)

    Sobolev, Andrey; Stoewer, Adrian; Leonhardt, Aljoscha; Rautenberg, Philipp L; Kellner, Christian J; Garbers, Christian; Wachtler, Thomas

    2014-01-01

    Recent advancements in technology and methodology have led to growing amounts of increasingly complex neuroscience data recorded from various species, modalities, and levels of study. The rapid data growth has made efficient data access and flexible, machine-readable data annotation a crucial requisite for neuroscientists. Clear and consistent annotation and organization of data is not only an important ingredient for reproducibility of results and re-use of data, but also essential for collaborative research and data sharing. In particular, efficient data management and interoperability requires a unified approach that integrates data and metadata and provides a common way of accessing this information. In this paper we describe GNData, a data management platform for neurophysiological data. GNData provides a storage system based on a data representation that is suitable to organize data and metadata from any electrophysiological experiment, with a functionality exposed via a common application programming interface (API). Data representation and API structure are compatible with existing approaches for data and metadata representation in neurophysiology. The API implementation is based on the Representational State Transfer (REST) pattern, which enables data access integration in software applications and facilitates the development of tools that communicate with the service. Client libraries that interact with the API provide direct data access from computing environments like Matlab or Python, enabling integration of data management into the scientist's experimental or analysis routines.

  2. Integrating Carbon Nanotubes into Microfluidic Chip for Separating Biochemical Compounds

    DEFF Research Database (Denmark)

    Chen, Miaoxiang Max; Mogensen, Klaus Bo; Bøggild, Peter

    2012-01-01

    We present a new type of device to separate biochemical compounds wherein carbon nanotubes (CNTs) are integrated as chromatographic stationary phase. The CNTs were directly grown on the bottom of microfluidic channels on Si/SiO2 substrates by chemical vapor deposition (CVD). Acetylene was used...

  3. Integrated chemiresistor array for small sensor platforms

    Energy Technology Data Exchange (ETDEWEB)

    HUGHES,ROBERT C.; CASALNUOVO,STEPHEN A.; WESSENDORF,KURT O.; SAVIGNON,DANIEL J.; HIETALA,SUSAN LESLIE; PATEL,SANJAY V.

    2000-04-13

    Chemiresistors are fabricated from materials that change their electrical resistance when exposed to certain chemical species. Composites of soluble polymers with metallic particles have shown remarkable sensitivity to many volatile organic chemicals, depending on the ability of the analyte molecules to swell the polymer matrix. These sensors can be made extremely small (< 100 square microns), operate at ambient temperatures, and require almost no power to read-out. However, the chemiresistor itself is only a part of a more complex sensor system that delivers chemical information to a user who can act on the information. The authors present the design, fabrication and performance of a chemiresistor array chip with four different chemiresistor materials, heaters and a temperature sensor. They also show the design and fabrication of an integrated chemiresistor array, where the electronics to read-out the chemiresistors is on the same chip with the electrodes for the chemiresistors. The circuit was designed to perform several functions to make the sensor data more useful. This low-power, integrated chemiresistor array is small enough to be deployed on a Sandia-developed microrobot platform.

  4. KinomeXplorer: an integrated platform for kinome biology studies

    DEFF Research Database (Denmark)

    Horn, Heiko; Schoof, Erwin; Kim, Jinho;

    2014-01-01

    A letter to the editor is presented related to the KinomeXplorer, an integrated platform providing workflows to efficiently analyze phosphorylation dependent interaction networks or kinase signaling networks.......A letter to the editor is presented related to the KinomeXplorer, an integrated platform providing workflows to efficiently analyze phosphorylation dependent interaction networks or kinase signaling networks....

  5. A hybrid approach to device integration on a genetic analysis platform

    Science.gov (United States)

    Brennan, Des; Jary, Dorothee; Kurg, Ants; Berik, Evgeny; Justice, John; Aherne, Margaret; Macek, Milan; Galvin, Paul

    2012-10-01

    Point-of-care (POC) systems require significant component integration to implement biochemical protocols associated with molecular diagnostic assays. Hybrid platforms where discrete components are combined in a single platform are a suitable approach to integration, where combining multiple device fabrication steps on a single substrate is not possible due to incompatible or costly fabrication steps. We integrate three devices each with a specific system functionality: (i) a silicon electro-wetting-on-dielectric (EWOD) device to move and mix sample and reagent droplets in an oil phase, (ii) a polymer microfluidic chip containing channels and reservoirs and (iii) an aqueous phase glass microarray for fluorescence microarray hybridization detection. The EWOD device offers the possibility of fully integrating on-chip sample preparation using nanolitre sample and reagent volumes. A key challenge is sample transfer from the oil phase EWOD device to the aqueous phase microarray for hybridization detection. The EWOD device, waveguide performance and functionality are maintained during the integration process. An on-chip biochemical protocol for arrayed primer extension (APEX) was implemented for single nucleotide polymorphism (SNiP) analysis. The prepared sample is aspirated from the EWOD oil phase to the aqueous phase microarray for hybridization. A bench-top instrumentation system was also developed around the integrated platform to drive the EWOD electrodes, implement APEX sample heating and image the microarray after hybridization.

  6. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications.

    Science.gov (United States)

    Cennamo, Nunzio; Chiavaioli, Francesco; Trono, Cosimo; Tombelli, Sara; Giannetti, Ambra; Baldini, Francesco; Zeni, Luigi

    2016-02-04

    An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay.

  7. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications

    Directory of Open Access Journals (Sweden)

    Nunzio Cennamo

    2016-02-01

    Full Text Available An optical sensor platform based on surface plasmon resonance (SPR in a plastic optical fiber (POF integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG/anti-IgG assay.

  8. Identifying And Weighting Integration Hypotheses On Open Data Platforms

    CERN Document Server

    Eberius, Julian; Thiele, Maik; Lehner, Wolfgang

    2012-01-01

    Open data platforms such as data.gov or opendata.socrata. com provide a huge amount of valuable information. Their free-for-all nature, the lack of publishing standards and the multitude of domains and authors represented on these platforms lead to new integration and standardization problems. At the same time, crowd-based data integration techniques are emerging as new way of dealing with these problems. However, these methods still require input in form of specific questions or tasks that can be passed to the crowd. This paper discusses integration problems on Open Data Platforms, and proposes a method for identifying and ranking integration hypotheses in this context. We will evaluate our findings by conducting a comprehensive evaluation using on one of the largest Open Data platforms.

  9. Complete integrability of information processing by biochemical reactions

    Science.gov (United States)

    Agliari, Elena; Barra, Adriano; Dello Schiavo, Lorenzo; Moro, Antonio

    2016-11-01

    Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kinetics, (anti-)ferromagnetic spin models in statistical mechanics and operational amplifiers/flip-flops in cybernetics. The underlying modeling - based on spin systems - has been proved to be accurate for a wide class of systems matching classical (e.g. Michaelis-Menten, Hill, Adair) scenarios in the infinite-size approximation. However, the current research in biochemical information processing has been focusing on systems involving a relatively small number of units, where this approximation is no longer valid. Here we show that the whole statistical mechanical description of reaction kinetics can be re-formulated via a mechanical analogy - based on completely integrable hydrodynamic-type systems of PDEs - which provides explicit finite-size solutions, matching recently investigated phenomena (e.g. noise-induced cooperativity, stochastic bi-stability, quorum sensing). The resulting picture, successfully tested against a broad spectrum of data, constitutes a neat rationale for a numerically effective and theoretically consistent description of collective behaviors in biochemical reactions.

  10. Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals.

    Science.gov (United States)

    Su, Fei; Xu, Ping

    2014-01-29

    Microbial strains with high substrate efficiency and excellent environmental tolerance are urgently needed for the production of platform bio-chemicals. Bacillus coagulans has these merits; however, little genetic information is available about this species. Here, we determined the genome sequences of five B. coagulans strains, and used a comparative genomic approach to reconstruct the central carbon metabolism of this species to explain their fermentation features. A novel xylose isomerase in the xylose utilization pathway was identified in these strains. Based on a genome-wide positive selection scan, the selection pressure on amino acid metabolism may have played a significant role in the thermal adaptation. We also researched the immune systems of B. coagulans strains, which provide them with acquired resistance to phages and mobile genetic elements. Our genomic analysis provides comprehensive insights into the genetic characteristics of B. coagulans and paves the way for improving and extending the uses of this species.

  11. Microfluidic Technology Platforms for Synthesizing, Labeling and Measuring the Kinetics of Transport and Biochemical Reactions for Developing Molecular Imaging Probes

    Energy Technology Data Exchange (ETDEWEB)

    Phelps, Michael E.

    2009-09-01

    Radiotracer techniques are used in environmental sciences, geology, biology and medicine. Radiotracers with Positron Emission Tomography (PET) provided biological examinations of ~3 million patients 2008. Despite the success of positron labeled tracers in many sciences, there is limited access in an affordable and convenient manner to develop and use new tracers. Integrated microfluidic chips are a new technology well matched to the concentrations of tracers. Our goal is to develop microfluidic chips and new synthesis approaches to enable wide dissemination of diverse types of tracers at low cost, and to produce new generations of radiochemists for which there are many unfilled jobs. The program objectives are to: 1. Develop an integrated microfluidic platform technology for synthesizing and 18F-labeling diverse arrays of different classes of molecules. 2. Incorporate microfluidic chips into small PC controlled devices (“Synthesizer”) with a platform interfaced to PC for electronic and fluid input/out control. 3. Establish a de-centralized model with Synthesizers for discovering and producing molecular imaging probes, only requiring delivery of inexpensive [18F]fluoride ion from commercial PET radiopharmacies vs the centralized approach of cyclotron facilities synthesizing and shipping a few different types of 18F-probes. 4. Develop a position sensitive avalanche photo diode (PSAPD) camera for beta particles embedded in a microfluidic chip for imaging and measuring transport and biochemical reaction rates to valid new 18F-labeled probes in an array of cell cultures. These objectives are met within a research and educational program integrating radio-chemistry, synthetic chemistry, biochemistry, engineering and biology in the Crump Institute for Molecular Imaging. The Radiochemistry Training Program exposes PhD and post doctoral students to molecular imaging in vitro in cells and microorganisms in microfluidic chips and in vivo with PET, from new technologies

  12. Microfluidic technology platforms for synthesizing, labeling and measuring the kinetics of transport and biochemical reactions for developing molecular imaging probes

    Energy Technology Data Exchange (ETDEWEB)

    Phelps, Michael E. [Univ. of California, Los Angeles, CA (United States)

    2009-09-01

    Radiotracer techniques are used in environmental sciences, geology, biology and medicine. Radiotracers with Positron Emission Tomography (PET) provided biological examinations of ~3 million patients 2008. Despite the success of positron labeled tracers in many sciences, there is limited access in an affordable and convenient manner to develop and use new tracers. Integrated microfluidic chips are a new technology well matched to the concentrations of tracers. Our goal is to develop microfluidic chips and new synthesis approaches to enable wide dissemination of diverse types of tracers at low cost, and to produce new generations of radiochemists for which there are many unfilled jobs. The program objectives are to: 1. Develop an integrated microfluidic platform technology for synthesizing and 18F-labeling diverse arrays of different classes of molecules. 2. Incorporate microfluidic chips into small PC controlled devices (“Synthesizer”) with a platform interfaced to PC for electronic and fluid input/out control. 3. Establish a de-centralized model with Synthesizers for discovering and producing molecular imaging probes, only requiring delivery of inexpensive [18F]fluoride ion from commercial PET radiopharmacies vs the centralized approach of cyclotron facilities synthesizing and shipping a few different types of 18F-probes. 4. Develop a position sensitive avalanche photo diode (PSAPD) camera for beta particles embedded in a microfluidic chip for imaging and measuring transport and biochemical reaction rates to valid new 18F-labeled probes in an array of cell cultures. These objectives are met within a research and educational program integrating radio-chemistry, synthetic chemistry, biochemistry, engineering and biology in the Crump Institute for Molecular Imaging. The Radiochemistry Training Program exposes PhD and post doctoral students to molecular imaging in vitro in cells and microorganisms in microfluidic chips and in vivo with PET, from new technologies

  13. Development of integrated platform for computational material design

    Energy Technology Data Exchange (ETDEWEB)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato [Center for Computational Science and Engineering, Fuji Research Institute Corporation (Japan); Hideaki, Koike [Advance Soft Corporation (Japan)

    2003-07-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned.

  14. A service integration platform for collaborative networks

    NARCIS (Netherlands)

    Osorio, A. L.; Afsarmanesh, H.; Camarinha-Matos, L.M.

    2011-01-01

    Integrated manufacturing constitutes a complex system made of heterogeneous information and control subsystems. Those subsystems are not designed to the cooperation. Typically each subsystem automates specific processes, and establishes closed application domains, therefore it is very difficult to i

  15. Current State and Development Trends for Integration Platforms

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The integration platform (IP) is an advanced support tool for application softwa re development and integration. This paper analyzes the shortcomings of traditio nal software programming methods, introduces the background and development of i ntegration platforms and presents the basic functions and system architecture of computer integrated manufacture computing environment (CCE) IP as well as the i ntegration framework. Computer integrated manufacturing system (CIMS) applicatio n IP is defined i n relation to the IP requirements for CIMS implementation within a company. The CIMS application IP is not only a support tool for application software developm ent, but also a support tool for software integration and system operation. Ther efore, the behavior and functions of a CIMS application IP must also include sof tware integration and system operation. The development trend for CIMS applicati on IPs is discussed in view of software technology development trends.

  16. From the Sugar Platform to biofuels and biochemicals : Final report for the European Commission Directorate-General Energy

    NARCIS (Netherlands)

    Taylor, R.; Nattrass, L.; Alberts, G.; Robson, P.; Chudziak, C.; Bauen, A.; Libelli, I.M.; Lotti, G.; Prussi, M.; Nistri, R.; Chiaramonti, D.; lópez-Contreras, A.M.; Bos, H.H.; Eggink, G.; Springer, J.; Bakker, R.; Ree, van R.

    2015-01-01

    Numerous potential pathways to biofuels and biochemicals exist via the sugar platform1. This study uses literature surveys, market data and stakeholder input to provide a comprehensive evidence base for policymakers and industry – identifying the key benefits and development needs for the sugar plat

  17. ENTERPRISE INTEGRATION PLATFORM BASED ON SERVICE- ORIENTED ARCHITECTURE

    Institute of Scientific and Technical Information of China (English)

    MENG Xiaojun; ZHANG Xu; NING Ruxin; SONG Yu

    2008-01-01

    To achieve information integration, process integration and application integration of enterprise, an enterprise integration platform (EIP) based on service-oriented architecture (SOA) is built. The enterprise integration model depending on encapsulating the business processes as well as the enterprise applications by the neutral and standard web services is presented. The problem how to discover the existed enterprise resources and share them was resolved depending on the mechanism of publishing and discovering the services. The EIP is integrated closely with product lifecycle management (PLM) system so that the process integration as well as orchestration of the business process services is implemented by encapsulating the workflow engine of PLM system. Not only process integration and application integration, but also information integration based on the bill of material (BOM) conversion driven by process are achieved. Finally, an interpretive, qualitative case study on EIP is conducted for this research.

  18. Snap: An Integrated SNP Annotation Platform

    DEFF Research Database (Denmark)

    Li, S.; Ma, L.; Li, H.;

    2007-01-01

    research. Using a user-friendly web interface, genes can be searched by name, description, position, SNP ID or clone name. Several public databases are integrated, including gene information from Ensembl, protein features from Uniprot/SWISS-PROT, Pfam and DAS-CBS. Gene relationships are fetched from BIND...

  19. A versatile, inexpensive integrated photonics platform

    CERN Document Server

    Shainline, Jeffrey M; Nader, Nima; Gentry, Cale M; Cossel, Kevin C; Popović, Miloš; Newbury, Nathan R; Nam, Sae Woo; Mirin, Richard P

    2016-01-01

    We present an approach to fabrication and packaging of integrated photonic devices that utilizes waveguide and detector layers deposited at near-ambient temperature. All lithography is performed with a 365 nm i-line stepper, facilitating low cost and high scalability. We have shown low-loss SiN waveguides, high-$Q$ ring resonators, critically coupled ring resonators, 50/50 beam splitters, Mach-Zehnder interferometers (MZIs) and a process-agnostic fiber packaging scheme. We have further explored the utility of this process for applications in nonlinear optics and quantum photonics. We demonstrate spectral tailoring and octave-spanning supercontinuum generation as well as the integration of superconducting nanowire single photon detectors with MZIs and channel-dropping filters. The packaging approach is suitable for operation up to 160 \\degree C as well as below 1 K. The process is well suited for augmentation of existing foundry capabilities or as a stand-alone process.

  20. Platforms for integrated nonlinear optics compatible with silicon integrated circuits

    CERN Document Server

    Moss, David J

    2014-01-01

    Nonlinear photonic chips are capable of generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. We review recent progress in CMOS-compatible platforms for nonlinear optics, focusing on Hydex glass and silicon nitride and briefly discuss the promising new platform of amorphous silicon. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation, ultrafast optical pulse generation and measurement. We highlight their potential future impact as well as the challenges to achieving practical solutions for many key applications.

  1. INTEGRATING FACEBOOK AND ALUMNI INTO THE SOCIAL NETWORK MOBILE PLATFORM

    Directory of Open Access Journals (Sweden)

    Tzuo-Ming Chen

    2014-06-01

    Full Text Available Social network systems have become one of the most popular Internet applications in recent years. Mobile devices such as smartphones and tablets make Internet access easier than ever before. They have also brought new opportunities for the social platforms of universities and their alumni. This paper proposes a mobile platform integrating the public social network site, facebook (FB, and universities' alumni. Before the users in this platform can contact the alumni, they must know their latest status from FB. Users can also gain alumni’s personal information with their authorization from the universities’ database. In addition, the mobile platform utilizes the Google Sync feature, which provides users of the system with ubiquitous information retrieval in any location and from any device.

  2. Aneka Cloud Application Platform and Its Integration with Windows Azure

    CERN Document Server

    Wei, Yi; Vecchiola, Christian; Karunamoorthy, Dileban; Buyya, Rajkumar

    2011-01-01

    Aneka is an Application Platform-as-a-Service (Aneka PaaS) for Cloud Computing. It acts as a framework for building customized applications and deploying them on either public or private Clouds. One of the key features of Aneka is its support for provisioning resources on different public Cloud providers such as Amazon EC2, Windows Azure and GoGrid. In this chapter, we will present Aneka platform and its integration with one of the public Cloud infrastructures, Windows Azure, which enables the usage of Windows Azure Compute Service as a resource provider of Aneka PaaS. The integration of the two platforms will allow users to leverage the power of Windows Azure Platform for Aneka Cloud Computing, employing a large number of compute instances to run their applications in parallel. Furthermore, customers of the Windows Azure platform can benefit from the integration with Aneka PaaS by embracing the advanced features of Aneka in terms of multiple programming models, scheduling and management services, application...

  3. Electrochemical Fabrication of Nanostructures on Porous Silicon for Biochemical Sensing Platforms.

    Science.gov (United States)

    Ko, Euna; Hwang, Joonki; Kim, Ji Hye; Lee, Joo Heon; Lee, Sung Hwan; Tran, Van-Khue; Chung, Woo Sung; Park, Chan Ho; Choo, Jaebum; Seong, Gi Hun

    2016-01-01

    We present a method for the electrochemical patterning of gold nanoparticles (AuNPs) or silver nanoparticles (AgNPs) on porous silicon, and explore their applications in: (1) the quantitative analysis of hydroxylamine as a chemical sensing electrode and (2) as a highly sensitive surface-enhanced Raman spectroscopy (SERS) substrate for Rhodamine 6G. For hydroxylamine detection, AuNPs-porous silicon can enhance the electrochemical oxidation of hydroxylamine. The current changed linearly for concentrations ranging from 100 μM to 1.32 mM (R(2) = 0.995), and the detection limit was determined to be as low as 55 μM. When used as SERS substrates, these materials also showed that nanoparticles decorated on porous silicon substrates have more SERS hot spots than those decorated on crystalline silicon substrates, resulting in a larger SERS signal. Moreover, AgNPs-porous silicon provided five-times higher signal compared to AuNPs-porous silicon. From these results, we expect that nanoparticles decorated on porous silicon substrates can be used in various types of biochemical sensing platforms.

  4. SpringSaLaD: A Spatial, Particle-Based Biochemical Simulation Platform with Excluded Volume.

    Science.gov (United States)

    Michalski, Paul J; Loew, Leslie M

    2016-02-02

    We introduce Springs, Sites, and Langevin Dynamics (SpringSaLaD), a comprehensive software platform for spatial, stochastic, particle-based modeling of biochemical systems. SpringSaLaD models biomolecules in a coarse-grained manner as a group of linked spherical sites with excluded volume. This mesoscopic approach bridges the gap between highly detailed molecular dynamics simulations and the various methods used to study network kinetics and diffusion at the cellular level. SpringSaLaD is a standalone tool that supports model building, simulation, visualization, and data analysis, all through a user-friendly graphical user interface that should make it more accessible than tools built into more comprehensive molecular dynamics infrastructures. Importantly, for bimolecular reactions we derive an exact expression relating the macroscopic on-rate to the various microscopic parameters with the inclusion of excluded volume; this makes SpringSaLaD more accurate than other tools, which rely on approximate relationships between these parameters.

  5. Fundamentals of power integrity for computer platforms and systems

    CERN Document Server

    DiBene, Joseph T

    2014-01-01

    An all-encompassing text that focuses on the fundamentals of power integrity Power integrity is the study of power distribution from the source to the load and the system level issues that can occur across it. For computer systems, these issues can range from inside the silicon to across the board and may egress into other parts of the platform, including thermal, EMI, and mechanical. With a focus on computer systems and silicon level power delivery, this book sheds light on the fundamentals of power integrity, utilizing the author's extensive background in the power integrity industry and un

  6. Analysis and Application for Integrity Model on Trusted Platform

    Institute of Scientific and Technical Information of China (English)

    TU Guo-qing; ZHANG Huan-guo; WANG Li-na; YU Dan-dan

    2005-01-01

    To build a trusted platform based on Trusted Computing Platform Alliance (TCPA) ' s recommendation,we analyze the integrity mechanism for such a PC platform in this paper. By combinning access control model with information flow model, we put forward a combined process-based lattice model to enforce security. This model creates a trust chain by which we can manage a series of processes from a core root of trust module to some other application modules.In the model, once the trust chain is created and managed correctly,the integrity of the computer's hardware and sofware has been mainfained, so does the confidentiality and authenticity. Moreover, a relevant implementation of the model is explained.

  7. Integrated control platform for converged optical and wireless networks

    DEFF Research Database (Denmark)

    Yan, Ying

    control platform design. To achieve an integrated and unified control platform, enhanced signalling protocol plays an important role in gluing the two different technologies. Consequently, an integrated resource management system is developed. Furthermore, and admission control scheme for connections......The next generation of broadband access networks is expected to be heterogeneous. Multiple wired and wireless systems can be integrated, in order to simultaneously provide seamless access with an appropriate Quality of Service (QoS). Wireless networks support ubiquitous connectivity yet low data...... the complementary characteristics of the optical networks and the wireless networks, addresses motivations for their interworking, discusses the current progress in hybrid network architectures as well as the functionalities of a control system, and identifies the achieved research contributions in the integrated...

  8. Biomass Program 2007 Peer Review - Integrated Biorefinery Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Integrated Biorefinery Platform Review held on August 13-15, 2007 in Golden, Colorado.

  9. Health Knowledge Effects: An Integrated Community Health Promotion Platform.

    Science.gov (United States)

    Chang, I-Chiu; Lin, Chih-Yu; Tseng, Hsiao-Ting; Ho, Wen-Yu

    2016-03-01

    The Taiwanese government subsidizes healthcare providers offering preventive medicine to patients to help reduce the threats of chronic sickness and halt skyrocketing medical expenditures. Usually, nurses are the primary workers who perform community health promotion; however, because of the chronic shortage of working nurses, many Taiwan hospitals have closed wards and deferred the responsibility of promoting primary prevention. With a community health promotion platform integrating interactive response features and Web sites for community patients and hospital staff, a case hospital efficiently sustained the community health services. The objective of this study was to assess the impact of the integrated community health promotion platform for conducting education. Fifty-four patients/residents were invited to join a quasi-experiment of health education, and a follow-up survey was conducted to assess the acceptance of the community health promotion platform from both the experimental group of learners/users and the hospital staff. The results showed that the community health promotion platform was effective in improving participant health awareness. The experimental group outperformed the control group, with higher posttest scores and longer knowledge retention. Furthermore, users indicated a high acceptance of the community health promotion platform.

  10. The Implementation of an Enterprise Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    XUJungang; WANGHongan; DAIGuozhong

    2004-01-01

    With the driving of rapid reaction to the changes of business rules, enterprises realize that they need to transfer their applications from single function to management of the whole processing flow. This transfer requires the enterprises to integrate the existing individual systems and re-configure its business systems. To meet this challenge, we have designed and implemented an Application integration platform for process industry (AIP/PI),which is model-driven and component-based, and composed of six main components: application configuration and execution platform, data accessing middleware, data collecting middleware, enterprise core database for production management, enterprise real-time database for production process, data integration and material balancing system. Our work has been applied to one refinery plant.

  11. Lasers in InP generic photonic integration technology platforms

    Science.gov (United States)

    Latkowski, Sylwester; Lenstra, Daan

    2015-04-01

    A review is given of a number of lasers in a form of photonic integrated circuits realized on InP substrate using a generic integration approach. The potential of these photonic circuits lies in their compactness, low power consumption, and significant reduction of fabrication cost by realization in generic foundry runs. Generic integration platforms offer the possibility of realizing functionally advanced photonic circuits using combinations of just a few standardized and parameterized building blocks. This vibrant field opens new doors to innovative product development for SMEs as well as curiosity-driven research.

  12. Photovoltaic System Test Platform with Integrated Battery Energy Storage Emulator

    DEFF Research Database (Denmark)

    Spataru, Sergiu; Sera, Dezso; Stroe, Daniel-Ioan

    2017-01-01

    In this work, we present a hybrid simulation and a real-time test platform for developing control systems for photovoltaic (PV) inverters with integrated battery energy storage (BES). The platform consists of a dual-stage single-phase PV inverter system, DC coupled with a full-bridge grid connected...... or directly to a physical PV array. The platform enables real-time testing of PV+BES control systems, including battery (BMS) and energy management systems (EMS), for a variety of battery technologies, which can be modelled in detail and emulated by the full-bridge grid connected inverter. Such flexibility...... is difficult to achieve with real BES systems, due to electrical safety and cost constrains of high power charge regulators and battery packs....

  13. Software for systems biology: from tools to integrated platforms.

    Science.gov (United States)

    Ghosh, Samik; Matsuoka, Yukiko; Asai, Yoshiyuki; Hsin, Kun-Yi; Kitano, Hiroaki

    2011-11-03

    Understanding complex biological systems requires extensive support from software tools. Such tools are needed at each step of a systems biology computational workflow, which typically consists of data handling, network inference, deep curation, dynamical simulation and model analysis. In addition, there are now efforts to develop integrated software platforms, so that tools that are used at different stages of the workflow and by different researchers can easily be used together. This Review describes the types of software tools that are required at different stages of systems biology research and the current options that are available for systems biology researchers. We also discuss the challenges and prospects for modelling the effects of genetic changes on physiology and the concept of an integrated platform.

  14. Wolfram technologies as an integrated scalable platform for interactive learning

    Science.gov (United States)

    Kaurov, Vitaliy

    2012-02-01

    We rely on technology profoundly with the prospect of even greater integration in the future. Well known challenges in education are a technology-inadequate curriculum and many software platforms that are difficult to scale or interconnect. We'll review an integrated technology, much of it free, that addresses these issues for individuals and small schools as well as for universities. Topics include: Mathematica, a programming environment that offers a diverse range of functionality; natural language programming for getting started quickly and accessing data from Wolfram|Alpha; quick and easy construction of interactive courseware and scientific applications; partnering with publishers to create interactive e-textbooks; course assistant apps for mobile platforms; the computable document format (CDF); teacher-student and student-student collaboration on interactive projects and web publishing at the Wolfram Demonstrations site.

  15. REopt: A Platform for Energy System Integration and Optimization: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Simpkins, T.; Cutler, D.; Anderson, K.; Olis, D.; Elgqvist, E.; Callahan, M.; Walker, A.

    2014-08-01

    REopt is NREL's energy planning platform offering concurrent, multi-technology integration and optimization capabilities to help clients meet their cost savings and energy performance goals. The REopt platform provides techno-economic decision-support analysis throughout the energy planning process, from agency-level screening and macro planning to project development to energy asset operation. REopt employs an integrated approach to optimizing a site?s energy costs by considering electricity and thermal consumption, resource availability, complex tariff structures including time-of-use, demand and sell-back rates, incentives, net-metering, and interconnection limits. Formulated as a mixed integer linear program, REopt recommends an optimally-sized mix of conventional and renewable energy, and energy storage technologies; estimates the net present value associated with implementing those technologies; and provides the cost-optimal dispatch strategy for operating them at maximum economic efficiency. The REopt platform can be customized to address a variety of energy optimization scenarios including policy, microgrid, and operational energy applications. This paper presents the REopt techno-economic model along with two examples of recently completed analysis projects.

  16. Toward an integrated software platform for systems pharmacology.

    Science.gov (United States)

    Ghosh, Samik; Matsuoka, Yukiko; Asai, Yoshiyuki; Hsin, Kun-Yi; Kitano, Hiroaki

    2013-12-01

    Understanding complex biological systems requires the extensive support of computational tools. This is particularly true for systems pharmacology, which aims to understand the action of drugs and their interactions in a systems context. Computational models play an important role as they can be viewed as an explicit representation of biological hypotheses to be tested. A series of software and data resources are used for model development, verification and exploration of the possible behaviors of biological systems using the model that may not be possible or not cost effective by experiments. Software platforms play a dominant role in creativity and productivity support and have transformed many industries, techniques that can be applied to biology as well. Establishing an integrated software platform will be the next important step in the field.

  17. Bioclipse 2: A scriptable integration platform for the life sciences

    Directory of Open Access Journals (Sweden)

    Wagener Johannes

    2009-12-01

    Full Text Available Abstract Background Contemporary biological research integrates neighboring scientific domains to answer complex questions in fields such as systems biology and drug discovery. This calls for tools that are intuitive to use, yet flexible to adapt to new tasks. Results Bioclipse is a free, open source workbench with advanced features for the life sciences. Version 2.0 constitutes a complete rewrite of Bioclipse, and delivers a stable, scalable integration platform for developers and an intuitive workbench for end users. All functionality is available both from the graphical user interface and from a built-in novel domain-specific language, supporting the scientist in interdisciplinary research and reproducible analyses through advanced visualization of the inputs and the results. New components for Bioclipse 2 include a rewritten editor for chemical structures, a table for multiple molecules that supports gigabyte-sized files, as well as a graphical editor for sequences and alignments. Conclusion Bioclipse 2 is equipped with advanced tools required to carry out complex analysis in the fields of bio- and cheminformatics. Developed as a Rich Client based on Eclipse, Bioclipse 2 leverages on today's powerful desktop computers for providing a responsive user interface, but also takes full advantage of the Web and networked (Web/Cloud services for more demanding calculations or retrieval of data. The fact that Bioclipse 2 is based on an advanced and widely used service platform ensures wide extensibility, making it easy to add new algorithms, visualizations, as well as scripting commands. The intuitive tools for end users and the extensible architecture make Bioclipse 2 ideal for interdisciplinary and integrative research. Bioclipse 2 is released under the Eclipse Public License (EPL, a flexible open source license that allows additional plugins to be of any license. Bioclipse 2 is implemented in Java and supported on all major platforms; Source code

  18. Integration of fractal biosensor in a digital microfluidic platform

    KAUST Repository

    Mashraei, Yousof

    2015-11-01

    Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

  19. MeDICi: An Open Platform for Sensor Integration

    Energy Technology Data Exchange (ETDEWEB)

    Wynne, Adam S.; Gorton, Ian; Chase, Jared M.; Stephan, Eric G.

    2009-09-04

    MeDICi (Middleware for Data Intensive Computing) is a platform for developing high performance, distributed streaming analytic and scientific applications. Developed at Pacific Northwest National Laboratory (PNNL), MeDICi has been released under an open source license and is based on enterprise-proven middleware technologies including a widely used Enterprise Service Bus (ESB), the standard Business Process Execution Language (BPEL), and open source message brokers. Wherever possible, we have built on existing open source, standards-based systems and integrated them into a coherent whole by creating simplified graphical programming tools such as a Workflow Designer and an easy to use and well-documented integration API. This software development approach allows us to: avoid re-creating complex service integration and orchestration systems, reap the benefits of continual improvements to the technology base, and focus on creating tools and APIs which allow for the creation of re-usable component-based software components applications and workflows. These aspects have facilitated rapid adoption of the platform within PNNL for demonstration and operational applications. In fact, MeDICi has been used for a wide range of integration projects including two sensor integration applications described later on in this paper. The remainder of this article white paper is organized as follows: Section 2 provides a high-level description of the MeDICi architecture. In Section 3, the open aspects of the API and tool development are highlighted. Section 4 explains system readiness by presenting relevant demonstrations and deployments. Finally documentation and licensing details are provided in Section 5

  20. Integrative set enrichment testing for multiple omics platforms

    Directory of Open Access Journals (Sweden)

    Poisson Laila M

    2011-11-01

    Full Text Available Abstract Background Enrichment testing assesses the overall evidence of differential expression behavior of the elements within a defined set. When we have measured many molecular aspects, e.g. gene expression, metabolites, proteins, it is desirable to assess their differential tendencies jointly across platforms using an integrated set enrichment test. In this work we explore the properties of several methods for performing a combined enrichment test using gene expression and metabolomics as the motivating platforms. Results Using two simulation models we explored the properties of several enrichment methods including two novel methods: the logistic regression 2-degree of freedom Wald test and the 2-dimensional permutation p-value for the sum-of-squared statistics test. In relation to their univariate counterparts we find that the joint tests can improve our ability to detect results that are marginal univariately. We also find that joint tests improve the ranking of associated pathways compared to their univariate counterparts. However, there is a risk of Type I error inflation with some methods and self-contained methods lose specificity when the sets are not representative of underlying association. Conclusions In this work we show that consideration of data from multiple platforms, in conjunction with summarization via a priori pathway information, leads to increased power in detection of genomic associations with phenotypes.

  1. Lightweight Integrated Optical Sensor for Atmospheric Measurements on Mobile Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Parameswaran, Krishnan R. [Physical Sciences Inc.

    2013-12-02

    The goal of the Phase I program was to develop a novel open path sensor platform technology based on integration of semiconductor waveguides with efficient optoelectronic components on a monolithic platform. The successful Phase I effort resulted in demonstration of a novel optical resonator structure based on semiconductor high contrast gratings (HCGs) that will enable implementation of an ultra-compact, low-power gas sensor suitable for use on mobile platforms. Extensive numerical modeling was performed to design a device optimized for measuring CO2 at a wavelength for which a laser was available for proof of concept. Devices were fabricated and tested to match the target wavelength, angle, and operating temperature. This demonstration is the first implementation of HCGs at the wavelengths of interest and shows the flexibility of the proposed architecture for gas sensing applications. The measured cavity Q was lower than anticipated due to fabrication process challenges. The PSI and UC Berkeley team has identified solutions to these challenges and will produce optimized devices in a Phase II program where a prototype sensor will be fabricated and tested.

  2. Integration of Fractal Biosensor in a Digital Microfluidic Platform

    KAUST Repository

    Mashraei, Yousof

    2016-06-08

    The digital microfluidic (DMF) platform introduces many applications in biomedical assays. If it is to be commercially available to the public, it needs to have the essential features of smart sensing and a compact size. In this work, we report on a fractal electrode biosensor that is used for both droplet actuation and sensing C-reactive protein (CRP) concentration levels to assess cardiac disease risk. Our proposed electrode is the first two-terminal electrode design to be integrated into DMF platforms. A simulation of the electrical field distribution shows reduced peak intensities and uniform distribution of the field. When compared to a V-notch square electrode, the fractal electrode shows a superior performance in both aspects, i.e. field uniformity and intensity. These improvements are translated into a successful and responsive actuation of a water droplet with 100V. Likewise, the effective dielectric strength is improved by a 33% increase in the fractal electrode breakdown voltage. Additionally, the capability of the fractal electrode to work as a capacitive biosensor is evaluated with CRP quantification test. Selected fractal electrodes undergo a surface treatment to immobilize anti-CRP antibodies on their surface. The measurement shows a response to the added CRP in capacitance within three minutes. When the untreated electrodes were used for quantification, there was no significant change in capacitance, and this suggested that immobilization was necessary. The electrodes configuration in the fabricated DMF platform allows the fractal electrodes to be selectively used as biosensors, which means the device could be integrated into point-of-care applications.

  3. Integrative disease classification based on cross-platform microarray data

    Directory of Open Access Journals (Sweden)

    Huang Haiyan

    2009-01-01

    Full Text Available Abstract Background Disease classification has been an important application of microarray technology. However, most microarray-based classifiers can only handle data generated within the same study, since microarray data generated by different laboratories or with different platforms can not be compared directly due to systematic variations. This issue has severely limited the practical use of microarray-based disease classification. Results In this study, we tested the feasibility of disease classification by integrating the large amount of heterogeneous microarray datasets from the public microarray repositories. Cross-platform data compatibility is created by deriving expression log-rank ratios within datasets. One may then compare vectors of log-rank ratios across datasets. In addition, we systematically map textual annotations of datasets to concepts in Unified Medical Language System (UMLS, permitting quantitative analysis of the phenotype "distance" between datasets and automated construction of disease classes. We design a new classification approach named ManiSVM, which integrates Manifold data transformation with SVM learning to exploit the data properties. Using the leave one dataset out cross validation, ManiSVM achieved the overall accuracy of 70.7% (68.6% precision and 76.9% recall with many disease classes achieving the accuracy higher than 80%. Conclusion Our results not only demonstrated the feasibility of the integrated disease classification approach, but also showed that the classification accuracy increases with the number of homogenous training datasets. Thus, the power of the integrative approach will increase with the continuous accumulation of microarray data in public repositories. Our study shows that automated disease diagnosis can be an important and promising application of the enormous amount of costly to generate, yet freely available, public microarray data.

  4. Integration of electrochemistry in micro-total analysis systems for biochemical assays: recent developments.

    Science.gov (United States)

    Xu, Xiaoli; Zhang, Song; Chen, Hui; Kong, Jilie

    2009-11-15

    Micro-total analysis systems (microTAS) integrate different analytical operations like sample preparation, separation and detection into a single microfabricated device. With the outstanding advantages of low cost, satisfactory analytical efficiency and flexibility in design, highly integrated and miniaturized devices from the concept of microTAS have gained widespread applications, especially in biochemical assays. Electrochemistry is shown to be quite compatible with microanalytical systems for biochemical assays, because of its attractive merits such as simplicity, rapidity, high sensitivity, reduced power consumption, and sample/reagent economy. This review presents recent developments in the integration of electrochemistry in microdevices for biochemical assays. Ingenious microelectrode design and fabrication methods, and versatility of electrochemical techniques are involved. Practical applications of such integrated microsystem in biochemical assays are focused on in situ analysis, point-of-care testing and portable devices. Electrochemical techniques are apparently suited to microsystems, since easy microfabrication of electrochemical elements and a high degree of integration with multi-analytical functions can be achieved at low cost. Such integrated microsystems will play an increasingly important role for analysis of small volume biochemical samples. Work is in progress toward new microdevice design and applications.

  5. Silicon-Nitride-based Integrated Optofluidic Biochemical Sensors using a Coupled-Resonator Optical Waveguide

    Directory of Open Access Journals (Sweden)

    Jiawei eWANG

    2015-04-01

    Full Text Available Silicon nitride (SiN is a promising material platform for integrating photonic components and microfluidic channels on a chip for label-free, optical biochemical sensing applications in the visible to near-infrared wavelengths. The chip-scale SiN-based optofluidic sensors can be compact due to a relatively high refractive index contrast between SiN and the fluidic medium, and low-cost due to the complementary metal-oxide-semiconductor (CMOS-compatible fabrication process. Here, we demonstrate SiN-based integrated optofluidic biochemical sensors using a coupled-resonator optical waveguide (CROW in the visible wavelengths. The working principle is based on imaging in the far field the out-of-plane elastic-light-scattering patterns of the CROW sensor at a fixed probe wavelength. We correlate the imaged pattern with reference patterns at the CROW eigenstates. Our sensing algorithm maps the correlation coefficients of the imaged pattern with a library of calibrated correlation coefficients to extract a minute change in the cladding refractive index. Given a calibrated CROW, our sensing mechanism in the spatial domain only requires a fixed-wavelength laser in the visible wavelengths as a light source, with the probe wavelength located within the CROW transmission band, and a silicon digital charge-coupled device (CCD / CMOS camera for recording the light scattering patterns. This is in sharp contrast with the conventional optical microcavity-based sensing methods that impose a strict requirement of spectral alignment with a high-quality cavity resonance using a wavelength-tunable laser. Our experimental results using a SiN CROW sensor with eight coupled microrings in the 680nm wavelength reveal a cladding refractive index change of ~1.3 × 10^-4 refractive index unit (RIU, with an average sensitivity of ~281 ± 271 RIU-1 and a noise-equivalent detection limit (NEDL of 1.8 ×10^-8 RIU ~ 1.0 ×10^-4 RIU across the CROW bandwidth of ~1 nm.

  6. Modeling and simulation of integrated luminescence detection platforms

    Science.gov (United States)

    Salama, Khaled; Eltoukhy, Helmy; Hassibi, Arjang; El Gamal, Abbas

    2003-07-01

    We developed a simulation model of an integrated CMOS-based imaging platform for use with bioluminescent DNA microarrays. We formulate the complete kinetic model of ATP based assays and luciferase label-based assays. The model first calculates the number of photons generated per unit time, i.e., photon flux, based upon the kinetics of the light generation process of luminescence probes. The photon flux coupled with the system geometry is then used to calculate the number of photons incident on the photodetector plane. Subsequently the characteristics of the imaging array including the photodetector spectral response, its dark current density, and the sensor conversion gain are incorporated. The model also takes into account different noise sources including shot noise, reset noise, readout noise and fixed pattern noise. Finally, signal processing algorithms are applied to the image to enhance detection reliability and hence increase the overall system throughput. We will present simulations and preliminary experimental results.

  7. TECHNOLOGY SUPPORTED LEARNING PLATFORM: Moodle Integrated Academic Course

    Directory of Open Access Journals (Sweden)

    Saziye YAMAN

    2010-04-01

    Full Text Available It is substantially accepted that constructivism proposes knowledge as “not a fixed object”; constructed by an individual through her own experiences. As a learning theory, constructivism in education emphasizes collaborative learning, such as authentic challenging projects involving in students, teachers and experts in the learning community. Its goal is to create learning communities that are more closely related to the collaborative practice of the real world as strongly reflected in social constructivist idea. The technologies used in the filed of education will support learning through collaborative practices, using learners’ experiences for “meaning making”. The challenge now is to extend the educational networks so that it offers access to learning resources, online storage and tools for communication and management not just within the limitation of school and time. Through learning platforms, such as Moodle, teachers and administrators may bring hardware, software and supporting services together to enable more effective conditions among teachers and students. In this study, Moodle was used to support the 4th grade pre-service language teachers’ (student teachers one of the academic courses, named as “Field Experience”. The student teachers were expected to prepare graduation theses in the field of English language teaching. Moodle was integrated as a technological learning aid and used as online support throughout a semester course. So, we will discuss how Moodle was integrated as a learning platform, while discussing, the use of Moodle as a “course supporter” process, steps and the sample activities will be presented as well.

  8. Turbine blade and non-integral platform with pin attachment

    Science.gov (United States)

    Campbell, Christian X; Eng, Darryl; Marra, John J

    2015-01-27

    Platforms (36, 38) span between turbine blades (23, 24, 25) on a disk (32). Each platform may be individually mounted to the disk by a pin attachment (42). Each platform (36) may have a rotationally rearward edge portion (50) that underlies a forward portion (45) of the adjacent platform (38). This limits centrifugal bending of the rearward portion of the platform, and provides coolant sealing. The rotationally forward edge (44A, 44B) of the platform overlies a seal element (51) on the pressure side (28) of the forwardly adjacent blade, and does not underlie a shelf on that blade. The pin attachment allows radial mounting of each platform onto the disk via tilting (60) of the platform during mounting to provide mounting clearance for the rotationally rearward edge portion (50). This facilitates quick platform replacement without blade removal.

  9. Turbine blade and non-integral platform with pin attachment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Christian Xavier; Eng, Darryl; Marra, John J.

    2016-08-02

    Platforms (36, 38) span between turbine blades (23, 24, 25) on a disk (32). Each platform may be individually mounted to the disk by a pin attachment (42). Each platform (36) may have a rotationally rearward edge portion (50) that underlies a forward portion (45) of the adjacent platform (38). This limits centrifugal bending of the rearward portion of the platform, and provides coolant sealing. The rotationally forward edge (44A, 44B) of the platform overlies a seal element (51) on the pressure side (28) of the forwardly adjacent blade, and does not underlie a shelf on that blade. The pin attachment allows radial mounting of each platform onto the disk via tilting (60) of the platform during mounting to provide mounting clearance for the rotationally rearward edge portion (50). This facilitates quick platform replacement without blade removal.

  10. Integrase and integration: biochemical activities of HIV-1 integrase

    Directory of Open Access Journals (Sweden)

    Deprez Eric

    2008-12-01

    Full Text Available Abstract Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration. The process of integration can be divided into two sequential reactions. The first one, named 3'-processing, corresponds to a specific endonucleolytic reaction which prepares the viral DNA extremities to be competent for the subsequent covalent insertion, named strand transfer, into the host cell genome by a trans-esterification reaction. Recently, a novel specific activity of the full length integrase was reported, in vitro, by our group for two retroviral integrases (HIV-1 and PFV-1. This activity of internal cleavage occurs at a specific palindromic sequence mimicking the LTR-LTR junction described into the 2-LTR circles which are peculiar viral DNA forms found during viral infection. Moreover, recent studies demonstrated the existence of a weak palindromic consensus found at the integration sites. Taken together, these data underline the propensity of retroviral integrases for binding symmetrical sequences and give perspectives for targeting specific sequences used for gene therapy.

  11. Drive to miniaturization: integrated optical networks on mobile platforms

    Science.gov (United States)

    Salour, Michael M.; Batayneh, Marwan; Figueroa, Luis

    2011-11-01

    With rapid growth of the Internet, bandwidth demand for data traffic is continuing to explode. In addition, emerging and future applications are becoming more and more network centric. With the proliferation of data communication platforms and data-intensive applications (e.g. cloud computing), high-bandwidth materials such as video clips dominating the Internet, and social networking tools, a networking technology is very desirable which can scale the Internet's capability (particularly its bandwidth) by two to three orders of magnitude. As the limits of Moore's law are approached, optical mesh networks based on wavelength-division multiplexing (WDM) have the ability to satisfy the large- and scalable-bandwidth requirements of our future backbone telecommunication networks. In addition, this trend is also affecting other special-purpose systems in applications such as mobile platforms, automobiles, aircraft, ships, tanks, and micro unmanned air vehicles (UAVs) which are becoming independent systems roaming the sky while sensing data, processing, making decisions, and even communicating and networking with other heterogeneous systems. Recently, WDM optical technologies have seen advances in its transmission speeds, switching technologies, routing protocols, and control systems. Such advances have made WDM optical technology an appealing choice for the design of future Internet architectures. Along these lines, scientists across the entire spectrum of the network architectures from physical layer to applications have been working on developing devices and communication protocols which can take full advantage of the rapid advances in WDM technology. Nevertheless, the focus has always been on large-scale telecommunication networks that span hundreds and even thousands of miles. Given these advances, we investigate the vision and applicability of integrating the traditionally large-scale WDM optical networks into miniaturized mobile platforms such as UAVs. We explain

  12. Towards Digital Integration: Platform Thinking in the Fashion Business

    DEFF Research Database (Denmark)

    Schou, Finn

    2005-01-01

    , 1998). The intention of this paper is, through illustrative case studies from France and Denmark within the highly competitive business of optical frame design (fashion) to present a model for strategy as well as a practical model for improvement of time to market of styling objects by use of digital...... platforms. Aspects are: 1) selection of platform from a strategic point of view, 2) selection of 2D and 3D CAD from a practical point of view and 3) creation and implementation of digital platforms. Finally, briefly aspects of teaching of platform theory at the department of Architecture & Industrial design...... at Aalborg University versus handling digital platforms in practice, are discussed....

  13. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks.

    Science.gov (United States)

    Biffi, Emilia; Piraino, Francesco; Pedrocchi, Alessandra; Fiore, Gianfranco B; Ferrigno, Giancarlo; Redaelli, Alberto; Menegon, Andrea; Rasponi, Marco

    2012-06-01

    Spatially and temporally resolved delivery of soluble factors is a key feature for pharmacological applications. In this framework, microfluidics coupled to multisite electrophysiology offers great advantages in neuropharmacology and toxicology. In this work, a microfluidic device for biochemical stimulation of neuronal networks was developed. A micro-chamber for cell culturing, previously developed and tested for long term neuronal growth by our group, was provided with a thin wall, which partially divided the cell culture region in two sub-compartments. The device was reversibly coupled to a flat micro electrode array and used to culture primary neurons in the same microenvironment. We demonstrated that the two fluidically connected compartments were able to originate two parallel neuronal networks with similar electrophysiological activity but functionally independent. Furthermore, the device allowed to connect the outlet port to a syringe pump and to transform the static culture chamber in a perfused one. At 14 days invitro, sub-networks were independently stimulated with a test molecule, tetrodotoxin, a neurotoxin known to block action potentials, by means of continuous delivery. Electrical activity recordings proved the ability of the device configuration to selectively stimulate each neuronal network individually. The proposed microfluidic approach represents an innovative methodology to perform biological, pharmacological, and electrophysiological experiments on neuronal networks. Indeed, it allows for controlled delivery of substances to cells, and it overcomes the limitations due to standard drug stimulation techniques. Finally, the twin network configuration reduces biological variability, which has important outcomes on pharmacological and drug screening.

  14. A Full CMOS Integration Including ISFET Microsensors and Interface Circuit for Biochemical Applications

    Institute of Scientific and Technical Information of China (English)

    Jinbao Wei; Haigang Yang; Hongguang Sun; Zengjin Lin; Shanhong Xia

    2006-01-01

    One of today's challenges is the integration of ISFETs in chemical and biochemical Microsystems. This article presents a full integration of ISFET chip containing the ISFET/REFET (reference FET) pair, ISFET/REFET amplifiers, bias current generator, as well as a reference electrode structure, all integrated on the same chip based on CMOS technology. The sensor chip was fabricated in a standard 0.35 μm CMOS process (Chartered Semiconductor, Singapore). The extra post processing steps have been developed and added for depositing membranes. Finally, the pH response of the integrated sensor was measured with the interface circuit.

  15. To design and construct an embedded knowledge integration service platform:Taking ISCAS subject group platform as an example

    Institute of Scientific and Technical Information of China (English)

    Yajing; LIU; Jinhui; ZHOU; Yanxi; WANG; Dan; HAO

    2014-01-01

    Purpose:As scientific resources are widely distributed,researchers often have difficulties in acquiring information from different individual sources.This paper intends to present a new approach to construct a subject-knowledge-based integration platform which was carried out by the Institute of Software,Chinese Academy of Sciences(ISCAS).Our aim is to use technique tools to strengthen the library service by combining a variety of information service resources with knowledge tools.Design/methodology/approach:Based on the analysis of users’ needs,we established a collaborative team across ISCAS Library,National Science Library of CAS(NSL CAS),and ISCAS’ research groups or research labs.With the service tools developed by ISCAS Library,we embedded other multipurpose utility tools of knowledge integration into the platform as to make full use of software tools in knowledge integration,knowledge fusion,and intelligent push of library services to end users.Findings:With a hard effort of the construction team,the ISCAS subject group platform(hereinafter as ISCAS Platform) has integrated such information resources as institutional repository(IR) of ISCAS,open resources from websites and subject resources of computer sciences.Up to date,ISCAS platform can provide integrated information services including data collection for computer science and intelligent generation of citation reports,by means of embedding self-developed discovering tools for domain experts and subject content,and generation tools for scientific citation reports.Research limitations:Knowledge organization need be further improved in the ISCAS subject group platform.In addition,functions for academic exchanges need be maximized as to meet the individual demands of researchers for library services at the Platform.Practical implications:Since we Platform has been put into use through the Library website of the ISCAS in June 2012,many academic libraries from both domestic universities and CAS institutes

  16. A service platform architecture design towards a light integration of heterogeneous systems in the wellbeing domain.

    Science.gov (United States)

    Yang, Yaojin; Ahtinen, Aino; Lahteenmaki, Jaakko; Nyman, Petri; Paajanen, Henrik; Peltoniemi, Teijo; Quiroz, Carlos

    2007-01-01

    System integration is one of the major challenges for building wellbeing or healthcare related information systems. In this paper, we are going to share our experiences on how to design a service platform called Nuadu service platform, for providing integrated services in occupational health promotion and health risk management through two heterogeneous systems. Our design aims for a light integration covering the layers, from data through service up to presentation, while maintaining the integrity of the underlying systems.

  17. Thermo-economic assessment of the integration of steam cycles on offshore platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    The integration of steam bottoming cycles on oil platforms is often seen as a possible route to mitigate the CO2-emissions offshore. In this paper, a North Sea platform and its energy requirements are systematically analysed. The site-scale integration of steam networks is assessed by using therm...

  18. a Workflow for UAV's Integration Into a Geodesign Platform

    Science.gov (United States)

    Anca, P.; Calugaru, A.; Alixandroae, I.; Nazarie, R.

    2016-06-01

    This paper presents a workflow for the development of various Geodesign scenarios. The subject is important in the context of identifying patterns and designing solutions for a Smart City with optimized public transportation, efficient buildings, efficient utilities, recreational facilities a.s.o.. The workflow describes the procedures starting with acquiring data in the field, data processing, orthophoto generation, DTM generation, integration into a GIS platform and analyzing for a better support for Geodesign. Esri's City Engine is used mostly for 3D modeling capabilities that enable the user to obtain 3D realistic models. The workflow uses as inputs information extracted from images acquired using UAVs technologies, namely eBee, existing 2D GIS geodatabases, and a set of CGA rules. The method that we used further, is called procedural modeling, and uses rules in order to extrude buildings, the street network, parcel zoning and side details, based on the initial attributes from the geodatabase. The resulted products are various scenarios for redesigning, for analyzing new exploitation sites. Finally, these scenarios can be published as interactive web scenes for internal, groups or pubic consultation. In this way, problems like the impact of new constructions being build, re-arranging green spaces or changing routes for public transportation, etc. are revealed through impact and visibility analysis or shadowing analysis and are brought to the citizen's attention. This leads to better decisions.

  19. An integrated platform for assessing biologics (Conference Presentation)

    Science.gov (United States)

    Schein, Perry; O'Dell, Dakota; Erickson, David

    2016-04-01

    Protein therapeutics are a rapidly growing portion of the pharmaceuticals market and have many significant advantages over traditional small molecule drugs. As this market expands, however, critical regulatory and quality control issues remain, most notably the problem of protein aggregation. Individual target proteins often aggregate into larger masses which trigger an immune response in the body, which can reduce the efficacy of the drug for its intended purpose, or cause serious anaphylactic side-effects. Although detecting and minimizing aggregate formation is critical to ensure an effective product, aggregation dynamics are often highly complicated and there is little hope of reliable prediction and prevention from first principles. This problem is compounded for aggregates in the subvisible range of 100 nm to 10 micrometers where traditional techniques for detecting aggregates have significant limitations. Here, we present an integrated optofluidic platform for detecting nanoscale protein aggregates and characterizing interactions between these aggregates and a reference surface. By delivering light to a solution of proteins with an optical waveguide, scattered light from individual protein aggregates can be detected and analyzed to determine the force profile between each particle and the waveguide surface. Unlike existing methods which only determine size or charge, our label-free screening technique can directly measure the surface interaction forces between single aggregates and the glass substrate. This direct measurement capability may allow for better empirical predictions of the stability of protein aggregates during drug manufacturing and storage.

  20. VOLTTRON Lite: Integration Platform for the Transactional Network

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Jereme N.; Katipamula, Srinivas; Akyol, Bora A.; Lutes, Robert G.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform. The platform is intended to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop units (RTUs) and the electric grid using applications or “agents” that reside on the platform, on the equipment, on local building controller or in the Cloud. This document describes the core of the transactional network platform, the Volttron Lite™ software and associated services hosted on the platform. Future enhancements are also discussed. The appendix of the document provides examples of how to use the various services hosted on the platform.

  1. 2011 Biomass Program Platform Peer Review. Integrated Biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Rossmeissl, Neil [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s IBR Platform Review meeting.

  2. A CORBA-Based Integration Platform of Product Development Process Management for Concurrent Engineering

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and inte gration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is de signed and developed. The design principles for IP-PDPM are described. The system architecture and func tions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.

  3. Vane array with one or more non-integral platforms

    Science.gov (United States)

    Lohaus, Andrew S.; Campbell, Christian Xavier; Miller, Jr, Samuel R.; Marra, John J.

    2016-07-12

    A vane array adapted to be coupled to a vane carrier within a gas turbine engine is provided comprising: a plurality of elongated airfoils comprising at least a first airfoil and a second airfoil located adjacent to one another; a U-ring; first connector structure for coupling a radially inner end section of each of the first and second airfoils to the U-ring; second connector structure for coupling a radially outer end section of each of the first and second airfoils to the vane carrier; a platform extending between the first and second airfoils; and platform connector structure for coupling the platform to one of the U-ring and the vane carrier.

  4. Apparatus, method and system to control accessibility of platform resources based on an integrity level

    Energy Technology Data Exchange (ETDEWEB)

    Jenkins, Chris; Pierson, Lyndon G.

    2016-10-25

    Techniques and mechanism to selectively provide resource access to a functional domain of a platform. In an embodiment, the platform includes both a report domain to monitor the functional domain and a policy domain to identify, based on such monitoring, a transition of the functional domain from a first integrity level to a second integrity level. In response to a change in integrity level, the policy domain may configure the enforcement domain to enforce against the functional domain one or more resource accessibility rules corresponding to the second integrity level. In another embodiment, the policy domain automatically initiates operations in aid of transitioning the platform from the second integrity level to a higher integrity level.

  5. Development of a Biosensor Nanofluidic Platform for Integration with Terahertz Spectroscopic System

    Science.gov (United States)

    2014-06-27

    Public Release; Distribution Unlimited Development of a Biosensor Nanofluidic Platform for Integration With Terahertz Spectroscopic System The views...VA 22902 -8734 ABSTRACT Number of Papers published in peer-reviewed journals: Development of a Biosensor Nanofluidic Platform for Integration With...in sub-THz range required less than 0.01 ng of dry material. The developed highly sensitive biosensors operating at room temperature with

  6. Multi-platform Integrated Positioning and Attitude Determination using GNSS

    NARCIS (Netherlands)

    Buist, P.J.

    2013-01-01

    There is trend in spacecraft engineering toward distributed systems where a number of smaller spacecraft work as a larger satellite. However, in order to make the small satellites work together as a single large platform, the precise relative positions (baseline) and orientations (attitude) of the e

  7. Development and Integration of a Pulsed 2-micron Direct Detection Integrated Path Differential Absorption (IPDA) Lidar for CO2 Column Measurement from Airborne platform Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop, integrate and demonstrate a 2-micron pulsed Integrated Path Differential Absorption Lidar (IPDA) instrument CO2 Column Measurement from Airborne platform...

  8. Integrating Software Architecture Concepts into the MDA Platform with UML Profile

    Directory of Open Access Journals (Sweden)

    Adel Alti

    2007-01-01

    Full Text Available Architecture Description Languages (ADLs provide an abstract representation of software systems. Achieving a concrete mapping of such representation into the implementation is one of the principal aspects of MDA (Model Driven Architecture. Integration of ADLs within MDA confers to the MDA platform a higher level of abstraction and a degree of reuse of ADLs. Indeed they have significantly different platform metamodels which make the definition of mapping rules complex. This complexity is clearly noticeable when some software architecture concepts cannot be easily mapped to MDA platform. In this research, we propose to integrate software architecture within MDA. We define also strategy for direct transformation using a UML profile. It represents both software architecture model (PIM and MDA platform model (PSM in UML meta-model then elaborates transformation rules between results UML meta-models. The goal is to automate the process of deriving implementation platform from software concepts.

  9. New CMOS Compatible Platforms for Integrated Nonlinear Optical Signal Processing

    CERN Document Server

    Moss, D J

    2014-01-01

    Nonlinear photonic chips have succeeded in generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon-on-insulator has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. This paper reviews some of the recent achievements in CMOS-compatible platforms for nonlinear optics, focusing on amorphous silicon and Hydex glass, highlighting their potential future impact as well as the challenges to achieving practical solutions for many key applications. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation and ultrafast optical pulse generation and measurement.

  10. Third-party Reverse logistics platform and method Based on Bilateral Resource Integration

    Directory of Open Access Journals (Sweden)

    Zheng Hong Zhen

    2016-01-01

    Full Text Available Dispersion of reverse logistics resources makes it difficult to create relationships between demanders and providers, thereby the personalized demand for the construction of enterprise reverse logistics cannot be satisfied and the service quality cannot be guaranteed. Aiming at these problems, this paper presents a platform and method of enterprise reverse logistics based on bilateral resource integration (RLBRI. The method creates a third-party reverse logistics platform to accumulate a mass of reverse logistics demanders and providers together. And the platform integrates bilateral resources and acts as an intermediary to establish relationships between two sides. Through the platform, a complete and high-quality business chain for enterprise reverse logistics will be built efficiently. Finally put forward an effective strategy of non-defective reverse logistics depends on the integrity checking service provided by third-party logistics. By using this strategy it can short the distance of non-defective reverse transportation. Computational tests validate the strategy.

  11. Development of Vacuum Vessel Design and Analysis Module for CFETR Integration Design Platform

    Directory of Open Access Journals (Sweden)

    Chen Zhu

    2016-01-01

    Full Text Available An integration design platform is under development for the design of the China Fusion Engineering Test Reactor (CFETR. It mainly includes the integration physical design platform and the integration engineering design platform. The integration engineering design platform aims at performing detailed engineering design for each tokamak component (e.g., breeding blanket, divertor, and vacuum vessel. The vacuum vessel design and analysis module is a part of the integration engineering design platform. The main idea of this module is to integrate the popular CAD/CAE software to form a consistent development environment. Specifically, the software OPTIMUS provides the approach to integrate the CAD/CAE software such as CATIA and ANSYS and form a design/analysis workflow for the vacuum vessel module. This design/analysis workflow could automate the process of modeling and finite element (FE analysis for vacuum vessel. Functions such as sensitivity analysis and optimization of geometric parameters have been provided based on the design/analysis workflow. In addition, data from the model and FE analysis could be easily exchanged among different modules by providing a unifying data structure to maintain the consistency of the global design. This paper describes the strategy and methodology of the workflow in the vacuum vessel module. An example is given as a test of the workflow and functions of the vacuum vessel module. The results indicate that the module is a feasible framework for future application.

  12. Enhancing Mobility: Integrating New Services into Your Library's Mobile Platform to Increase Traffic

    Science.gov (United States)

    Felts, John W., Jr.

    2014-01-01

    Kimbel Library launched its mobile environment and ran it in full production for several months yet usage patterns were quite low and flat. The library only saw a substantial increase in usage when new, value-added services were integrated into this platform. Upon implementing and integrating discovery services, chat and SMS capabilities, and…

  13. Research on application information system integration platform in medicine manufacturing enterprise.

    Science.gov (United States)

    Deng, Wu; Zhao, Huimin; Zou, Li; Li, Yuanyuan; Li, Zhengguang

    2012-08-01

    Computer and information technology popularizes in the medicine manufacturing enterprise for its potentials in working efficiency and service quality. In allusion to the explosive data and information of application system in current medicine manufacturing enterprise, we desire to propose a novel application information system integration platform in medicine manufacturing enterprise, which based on a combination of RFID technology and SOA, to implement information sharing and alternation. This method exploits the application integration platform across service interface layer to invoke the RFID middleware. The loose coupling in integration solution is realized by Web services. The key techniques in RFID event components and expanded role-based security access mechanism are studied in detail. Finally, a case study is implemented and tested to evidence our understanding on application system integration platform in medicine manufacturing enterprise.

  14. A middleware-based platform for the integration of bioinformatic services

    Directory of Open Access Journals (Sweden)

    Guzmán Llambías

    2015-08-01

    Full Text Available Performing Bioinformatic´s experiments involve an intensive access to distributed services and information resources through Internet. Although existing tools facilitate the implementation of workflow-oriented applications, they lack of capabilities to integrate services beyond low-scale applications, particularly integrating services with heterogeneous interaction patterns and in a larger scale. This is particularly required to enable a large-scale distributed processing of biological data generated by massive sequencing technologies. On the other hand, such integration mechanisms are provided by middleware products like Enterprise Service Buses (ESB, which enable to integrate distributed systems following a Service Oriented Architecture. This paper proposes an integration platform, based on enterprise middleware, to integrate Bioinformatics services. It presents a multi-level reference architecture and focuses on ESB-based mechanisms to provide asynchronous communications, event-based interactions and data transformation capabilities. The paper presents a formal specification of the platform using the Event-B model.

  15. An integrated image analysis platform to quantify signal transduction in single cells

    OpenAIRE

    Pelet, Serge; Dechant, Reinhard; Lee, Sung Sik; van Drogen, Frank; Peter, Matthias

    2012-01-01

    Microscopy can provide invaluable information about biological processes at the single cell level. It remains a challenge, however, to extract quantitative information from these types of datasets. We have developed an image analysis platform named YeastQuant to simplify data extraction by offering an integrated method to turn time-lapse movies into single cell measurements. This platform is based on a database with a graphical user interface where the users can describe their experiments....

  16. Oil and gas platforms with steam bottoming cycles: System integration and thermoenvironomic evaluation

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    The integration of steam bottoming cycles on oil and gas platforms is currently regarded as the most promising option for improving the performance of these energy-intensive systems. In this paper, a North Sea platform is taken as case study, and a systematic analysis of its energy requirements...... cooling utility, and (iv) the weight limitations on the platform are quantitatively assessed. The results illustrate the benefits of converting the gas turbine process into a combined cycle, since the fuel gas consumption and the total CO2-emissions can be reduced by more than 15 %. Using the cooling...

  17. A chip-scale integrated cavity-electro-optomechanics platform

    DEFF Research Database (Denmark)

    Winger, M.; Blasius, T. D.; Mayer Alegre, T. P.;

    2011-01-01

    We present an integrated optomechanical and electromechanical nanocavity, in which a common mechanical degree of freedom is coupled to an ultrahigh-Q photonic crystal defect cavity and an electrical circuit. The system allows for wide-range, fast electrical tuning of the optical nanocavity...... resonances, and for electrical control of optical radiation pressure back-action effects such as mechanical amplification (phonon lasing), cooling, and stiffening. These sort of integrated devices offer a new means to efficiently interconvert weak microwave and optical signals, and are expected to pave...

  18. An integrated platform for image-guided cardiac resynchronization therapy

    Science.gov (United States)

    Ma, Ying Liang; Shetty, Anoop K.; Duckett, Simon; Etyngier, Patrick; Gijsbers, Geert; Bullens, Roland; Schaeffter, Tobias; Razavi, Reza; Rinaldi, Christopher A.; Rhode, Kawal S.

    2012-05-01

    Cardiac resynchronization therapy (CRT) is an effective procedure for patients with heart failure but 30% of patients do not respond. This may be due to sub-optimal placement of the left ventricular (LV) lead. It is hypothesized that the use of cardiac anatomy, myocardial scar distribution and dyssynchrony information, derived from cardiac magnetic resonance imaging (MRI), may improve outcome by guiding the physician for optimal LV lead positioning. Whole heart MR data can be processed to yield detailed anatomical models including the coronary veins. Cine MR data can be used to measure the motion of the LV to determine which regions are late-activating. Finally, delayed Gadolinium enhancement imaging can be used to detect regions of scarring. This paper presents a complete platform for the guidance of CRT using pre-procedural MR data combined with live x-ray fluoroscopy. The platform was used for 21 patients undergoing CRT in a standard catheterization laboratory. The patients underwent cardiac MRI prior to their procedure. For each patient, a MRI-derived cardiac model, showing the LV lead targets, was registered to x-ray fluoroscopy using multiple views of a catheter looped in the right atrium. Registration was maintained throughout the procedure by a combination of C-arm/x-ray table tracking and respiratory motion compensation. Validation of the registration between the three-dimensional (3D) roadmap and the 2D x-ray images was performed using balloon occlusion coronary venograms. A 2D registration error of 1.2 ± 0.7 mm was achieved. In addition, a novel navigation technique was developed, called Cardiac Unfold, where an entire cardiac chamber is unfolded from 3D to 2D along with all relevant anatomical and functional information and coupled to real-time device detection. This allowed more intuitive navigation as the entire 3D scene was displayed simultaneously on a 2D plot. The accuracy of the unfold navigation was assessed off-line using 13 patient data sets

  19. Accuracy assessment of the integration of GNSS and a MEMS IMU in a terrestrial platform.

    Science.gov (United States)

    Madeira, Sergio; Yan, Wenlin; Bastos, Luísa; Gonçalves, José A

    2014-11-04

    MEMS Inertial Measurement Units are available at low cost and can replace expensive units in mobile mapping platforms which need direct georeferencing. This is done through the integration with GNSS measurements in order to achieve a continuous positioning solution and to obtain orientation angles. This paper presents the results of the assessment of the accuracy of a system that integrates GNSS and a MEMS IMU in a terrestrial platform. We describe the methodology used and the tests realized where the accuracy of the positions and orientation parameters were assessed using an independent photogrammetric technique employing cameras that integrate the mobile mapping system developed by the authors. Results for the accuracy of attitude angles and coordinates show that accuracies better than a decimeter in positions, and under a degree in angles, can be achieved even considering that the terrestrial platform is operating in less than favorable environments.

  20. Integrated genome browser: visual analytics platform for genomics

    OpenAIRE

    2016-01-01

    Motivation: Genome browsers that support fast navigation through vast datasets and provide interactive visual analytics functions can help scientists achieve deeper insight into biological systems. Toward this end, we developed Integrated Genome Browser (IGB), a highly configurable, interactive and fast open source desktop genome browser. Results: Here we describe multiple updates to IGB, including all-new capabilities to display and interact with data from high-throughput sequencing experime...

  1. Integrated assessment of biochemical responses in Mediterranean crab (Carcinus maenas) collected from Monastir Bay, Tunisia

    Institute of Scientific and Technical Information of China (English)

    Jamel Jebali; Sana Ben-Khedher; Jihene Ghedira; Nawel Kamel; Hamadi Boussetta

    2011-01-01

    The biochemical response of Mediteranean Crab (Carcinus maenas) collected at five stations of Monastir Bay and from Kuriat station as control was studied using a set of complementary biomarkers.The catalase,glutathione S-transferase,lactate dehydrogenase,acetycholinesterase activities; and metallothionein and malonediladehyde levels in gills were evaluated.Results revealed differences among sites in relation to each specific biomarker.Hence,a suite of biomarkers can be used to discriminate sampling sites according to types of pollution,reflecting differing conditions of anthropogenic impact.Based on Integrated Biomarker Response,the highest values and critical biochemical alteration were observed at Khniss and Ksibat in response to urban and industrial discharges and the lowest IBR value was found at reference site.The current study has shown dearly that a biomarker-based index is usefulness tool in the monitoring Tunisian coast using C.maenas as sentinel specie.Further studies in progress to investigate the seasonal variations of IBR levels and its relationship to pollutants concentrations in the sediment,gills and digestive gland of Carcinus maenas from Monastir Bay.

  2. An integrated photocatalytic microfluidic platform enabling total phosphorus digestion

    Science.gov (United States)

    Tong, Jianhua; Dong, Tian; Bian, Chao; Wang, Minrui; Wang, Fangfang; Bai, Yin; Xia, Shanhong

    2015-02-01

    This paper presents an integrated thermally assisted photocatalytic microfluidic chip and its application to the digestion of total phosphorus (TP) in freshwater. A micro heater, a micro temperature sensor, thermal-isolation channels and a polymethylsiloxane (PDMS) reaction chamber were fabricated on the microfluidic chip. Nano-TiO2 film sputtered on the surface of silicon in the reaction area was used as the photocatalyst, and a micro ultraviolet A-ray-light-emitting diode (UVA-LED) array fabricated by MEMS technology were attached to the top of reaction chamber for TP degradation. In this study, sodium tripolyphosphate (Na5P3O10) and sodium glycerophosphate (C3H7Na2O6P) were chosen as the typical components of TP, and these water samples were digested under UVA light irradiation and heating at the same time. Compared with the conventional high-temperature TP digestion which works at 120 °C for 30 min, the thermally assisted UVA digestion method could work at relatively low temperature, and the power consumption is decreased to less than 2 W. Since this digestion method could work without an oxidizing reagent, it is compatible with the electrochemical detection process, which makes it possible to achieve a fully functional detection chip by integrating the digestion unit and electrochemical microelectrode, to realize the on-chip detection of TP, and other water quality parameters such as total nitrogen and chemical oxygen demand.

  3. Hybrid Integrated Silicon Microfluidic Platform for Fluorescence Based Biodetection

    Directory of Open Access Journals (Sweden)

    André Darveau

    2007-09-01

    Full Text Available The desideratum to develop a fully integrated Lab-on-a-chip device capable ofrapid specimen detection for high throughput in-situ biomedical diagnoses and Point-of-Care testing applications has called for the integration of some of the novel technologiessuch as the microfluidics, microphotonics, immunoproteomics and Micro ElectroMechanical Systems (MEMS. In the present work, a silicon based microfluidic device hasbeen developed for carrying out fluorescence based immunoassay. By hybrid attachment ofthe microfluidic device with a Spectrometer-on-chip, the feasibility of synthesizing anintegrated Lab-on-a-chip type device for fluorescence based biosensing has beendemonstrated. Biodetection using the microfluidic device has been carried out usingantigen sheep IgG and Alexafluor-647 tagged antibody particles and the experimentalresults prove that silicon is a compatible material for the present application given thevarious advantages it offers such as cost-effectiveness, ease of bulk microfabrication,superior surface affinity to biomolecules, ease of disposability of the device etc., and is thussuitable for fabricating Lab-on-a-chip type devices.

  4. An integrated image processing platform designed for Chinese GF-1 wide field view data

    Science.gov (United States)

    Li, Zhishan; Shi, Runhe; Liu, Chaoshun; Chen, Maosi

    2016-09-01

    The Wide Field View (WFV), a space borne multi-spectral sensor onboard the Chinese GaoFen-1 (GF-1) satellite from the China High-resolution Earth Observation System, is operating in orbit dedicating to providing Earth observation with decametric spatial resolution, high temporal resolution and wide coverage for environment monitoring purpose. The objective of this study is to present an integrated image processing and environment monitoring platform specifically for GF-1 WFV data. The platform is developed with a multi-layer architecture and C/S structure, which primarily consists of image pre-processing, environment monitoring, data visualization, and results output modules. The client application was created by using C# whereas IDL was used to develop image processing and other relevant algorithms. This paper focuses mainly on the overall design of the platform and related key techniques. The platform has been implemented as a stand-alone application, and successfully implemented in real world environment monitoring studies.

  5. OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-04-01

    The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The five sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.

  6. Microfluidic-optical integrated CMOS compatible devices for label-free biochemical sensing

    Science.gov (United States)

    Blanco, F. J.; Agirregabiria, M.; Berganzo, J.; Mayora, K.; Elizalde, J.; Calle, A.; Dominguez, C.; Lechuga, L. M.

    2006-05-01

    The fabrication, characterization and packaging of novel microfluidic-optical integrated biosensors for label-free biochemical detection is presented in this paper. The integrated device consists of a three-dimensional embedded microchannel network fabricated using enhanced CMOS compatible SU-8 multilevel polymer technology on top of a wafer containing Mach-Zehnder Interferometer (MZI) nanophotonic biosensor devices. PMMA housing provides connection to the macro-world and ensures robust leakage-free flow operation of the devices. This macro-microfluidic module can operate at pressure drops up to 1000 kPa. Fluid flow experiments have been performed in order to demonstrate the robustness of our microfluidic devices. The devices have been designed to operate under continuous flow. Steady-state flow rates ranging from 1 to 100 µl min-1 at pressure drops ranging from 10 to 500 kPa were measured in the laminar flow regime. Experimental results are in good agreement with laminar flow theory. The first interferometric sensing measurements are presented in order to demonstrate the functionality of these novel integrated devices for lab-on-a-chip and label-free biosensing applications. A bulk refractive index detection limit of 3.8 × 10-6 was obtained, close to the minimum detected up to now by label-free biosensor devices without microfluidic integration. As far as we know, this is the first time that a label-free biosensor device is integrated within a microfluidic network using a wafer-level CMOS compatible process technology.

  7. Integrated nanophotonic frequency shifter on the silicon-organic hybrid (SOH) platform for laser vibrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lauermann, M.; Weimann, C.; Palmer, R.; Schindler, P. C. [Institute of Photonics and Quantum Electronics, Karlsruhe Institute of Technology, 76131 Karlsruhe (Germany); Koeber, S.; Freude, W., E-mail: christian.koos@kit.edu; Koos, C., E-mail: christian.koos@kit.edu [Institute of Photonics and Quantum Electronics, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany and Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen (Germany); Rembe, C. [Polytec GmbH, 76337 Waldbronn (Germany)

    2014-05-27

    We demonstrate a waveguide-based frequency shifter on the silicon photonic platform, enabling frequency shifts up to 10 GHz. The device is realized by silicon-organic hybrid (SOH) integration. Temporal shaping of the drive signal allows the suppression of spurious side-modes by more than 23 dB.

  8. Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human-Activity Monitoringand Personal Healthcare.

    Science.gov (United States)

    Trung, Tran Quang; Lee, Nae-Eung

    2016-06-01

    Flexible and stretchable physical sensors that can measure and quantify electrical signals generated by human activities are attracting a great deal of attention as they have unique characteristics, such as ultrathinness, low modulus, light weight, high flexibility, and stretchability. These flexible and stretchable physical sensors conformally attached on the surface of organs or skin can provide a new opportunity for human-activity monitoring and personal healthcare. Consequently, in recent years there has been considerable research effort devoted to the development of flexible and stretchable physical sensors to fulfill the requirements of future technology, and much progress has been achieved. Here, the most recent developments of flexible and stretchable physical sensors are described, including temperature, pressure, and strain sensors, and flexible and stretchable sensor-integrated platforms. The latest successful examples of flexible and stretchable physical sensors for the detection of temperature, pressure, and strain, as well as their novel structures, technological innovations, and challenges, are reviewed first. In the next section, recent progress regarding sensor-integrated wearable platforms is overviewed in detail. Some of the latest achievements regarding self-powered sensor-integrated wearable platform technologies are also reviewed. Further research direction and challenges are also proposed to develop a fully sensor-integrated wearable platform for monitoring human activity and personal healthcare in the near future.

  9. Integration of approaches in David Wake's model-taxon research platform for evolutionary morphology.

    Science.gov (United States)

    Griesemer, James

    2013-12-01

    What gets integrated in integrative scientific practices has been a topic of much discussion. Traditional views focus on theories and explanations, with ideas of reduction and unification dominating the conversation. More recent ideas focus on disciplines, fields, or specialties; models, mechanisms, or methods; phenomena, problems. How integration works looks different on each of these views since the objects of integration are ontologically and epistemically various: statements, boundary conditions, practices, protocols, methods, variables, parameters, domains, laboratories, and questions all have their own structures, functions and logics. I focus on one particular kind of scientific practice, integration of "approaches" in the context of a research system operating on a special kind of "platform." Rather than trace a network of interactions among people, practices, and theoretical entities to be integrated, in this essay I focus on the work of a single investigator, David Wake. I describe Wake's practice of integrative evolutionary biology and how his integration of approaches among biological specialties worked in tandem with his development of the salamanders as a model taxon, which he used as a platform to solve, re-work and update problems that would not have been solved so well by non-integrative approaches. The larger goal of the project to which this paper contributes is a counter-narrative to the story of 20th century life sciences as the rise and march of the model organisms and decline of natural history.

  10. SysBioCube: A Data Warehouse and Integrative Data Analysis Platform Facilitating Systems Biology Studies of Disorders of Military Relevance.

    Science.gov (United States)

    Chowbina, Sudhir; Hammamieh, Rasha; Kumar, Raina; Chakraborty, Nabarun; Yang, Ruoting; Mudunuri, Uma; Jett, Marti; Palma, Joseph M; Stephens, Robert

    2013-01-01

    SysBioCube is an integrated data warehouse and analysis platform for experimental data relating to diseases of military relevance developed for the US Army Medical Research and Materiel Command Systems Biology Enterprise (SBE). It brings together, under a single database environment, pathophysio-, psychological, molecular and biochemical data from mouse models of post-traumatic stress disorder and (pre-) clinical data from human PTSD patients.. SysBioCube will organize, centralize and normalize this data and provide an access portal for subsequent analysis to the SBE. It provides new or expanded browsing, querying and visualization to provide better understanding of the systems biology of PTSD, all brought about through the integrated environment. We employ Oracle database technology to store the data using an integrated hierarchical database schema design. The web interface provides researchers with systematic information and option to interrogate the profiles of pan-omics component across different data types, experimental designs and other covariates.

  11. Ecological risk assessment of impacted estuarine areas: integrating histological and biochemical endpoints in wild Senegalese sole.

    Science.gov (United States)

    Gonçalves, Cátia; Martins, Marta; Costa, Maria H; Caeiro, Sandra; Costa, Pedro M

    2013-09-01

    The analysis of multiple biomarker responses is nowadays recognized as a valuable tool to circumvent potential confounding factors affecting biomonitoring studies and allows a better understanding of the mechanisms underlying exposure to natural mixtures of toxicants. For the purpose of an environmental risk assessment (ERA) in an impacted estuary in SW Europe (the Sado, Portugal), juvenile Solea senegalensis from commercial fishing areas were surveyed for histopathological liver alterations and biochemical biomarkers. Although the findings revealed moderate differences in the patterns of histopathological traits between urban/industrial- and agricultural-influenced areas within the same estuary, no significant distinction was found between the cumulative alterations in animals from the two sites. The overall level of histopathological injury was low and severe traits like neoplasms or pre-neoplastic foci were absent. While metallothionein induction and lipid peroxidation could relate to histopathological condition indices, the activity of anti-oxidant enzymes appeared to be impaired in animals collected off the estuary's heavy-industry belt (the most contaminated site), which may partially explain some degree of hepatic integrity loss. Overall, the results are consistent with low-moderate contamination of the estuary and indicate that oxidative stress is the most important factor accounting for differences between sites. The study highlights the need of integrating multiple biomarkers when multiple environmental stressors are involved and the advantages of surveying toxicity effects in field-collected, foraging, organisms.

  12. Model-to-model transformations of architecture descriptions of an integration platform

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2014-04-01

    Full Text Available Model transformations play a key role in any software development project based on Mod-el-Driven Engineering (MDE principles. However, little attention has been paid to the ap-plication of MDE principles to automate the design of integration solutions. The aim of the paper is to present transformations of a model-to-model type, used to automate the process of integration platform's architecture description. The transformations have been designed to enable the generation of model elements, according to the '1+5' architectural views model adjusted to the integration solutions description. Design and implementation of transformations were performed in the IBM Rational Software Architect (RSA environ-ment. Authorial UML profiles: UML Profile for Integration Platform and UML Profile for Integration Flows have been used. The paper covers transformations between models in the following architectural views: Integrated Processes; Use Cases; Logical and Integrated Services. The transformations occur at the levels of business processes, requirements speci-fication and system design. Using the transformations, it is possible to generate models, diagrams, model elements and relationships between them. The complete environment has been obtained to automate architectural description of an integration solution. Transfor-mations ensure completeness of the architectural description and consistency of elements between models.

  13. An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes

    Science.gov (United States)

    Guldner, Ian H.; Yang, Lin; Cowdrick, Kyle R.; Wang, Qingfei; Alvarez Barrios, Wendy V.; Zellmer, Victoria R.; Zhang, Yizhe; Host, Misha; Liu, Fang; Chen, Danny Z.; Zhang, Siyuan

    2016-04-01

    Metastatic microenvironments are spatially and compositionally heterogeneous. This seemingly stochastic heterogeneity provides researchers great challenges in elucidating factors that determine metastatic outgrowth. Herein, we develop and implement an integrative platform that will enable researchers to obtain novel insights from intricate metastatic landscapes. Our two-segment platform begins with whole tissue clearing, staining, and imaging to globally delineate metastatic landscape heterogeneity with spatial and molecular resolution. The second segment of our platform applies our custom-developed SMART 3D (Spatial filtering-based background removal and Multi-chAnnel forest classifiers-based 3D ReconsTruction), a multi-faceted image analysis pipeline, permitting quantitative interrogation of functional implications of heterogeneous metastatic landscape constituents, from subcellular features to multicellular structures, within our large three-dimensional (3D) image datasets. Coupling whole tissue imaging of brain metastasis animal models with SMART 3D, we demonstrate the capability of our integrative pipeline to reveal and quantify volumetric and spatial aspects of brain metastasis landscapes, including diverse tumor morphology, heterogeneous proliferative indices, metastasis-associated astrogliosis, and vasculature spatial distribution. Collectively, our study demonstrates the utility of our novel integrative platform to reveal and quantify the global spatial and volumetric characteristics of the 3D metastatic landscape with unparalleled accuracy, opening new opportunities for unbiased investigation of novel biological phenomena in situ.

  14. Nucleic Acid-based Detection of Bacterial Pathogens Using Integrated Microfluidic Platform Systems

    Directory of Open Access Journals (Sweden)

    Carl A. Batt

    2009-05-01

    Full Text Available The advent of nucleic acid-based pathogen detection methods offers increased sensitivity and specificity over traditional microbiological techniques, driving the development of portable, integrated biosensors. The miniaturization and automation of integrated detection systems presents a significant advantage for rapid, portable field-based testing. In this review, we highlight current developments and directions in nucleic acid-based micro total analysis systems for the detection of bacterial pathogens. Recent progress in the miniaturization of microfluidic processing steps for cell capture, DNA extraction and purification, polymerase chain reaction, and product detection are detailed. Discussions include strategies and challenges for implementation of an integrated portable platform.

  15. Optimizing integrated optical chips for label-free (bio-)chemical sensing.

    Science.gov (United States)

    Kunz, R E; Cottier, K

    2006-01-01

    Label-free sensing is an important method for many (bio-)chemical applications in fields such as biotechnology, medicine, pharma, ecology and food quality control. The broad range of applications includes liquid refractive index sensing, molecule detection, and the detection of particles or cells. Integrated optics based on the use of waveguide modes offers a great potential and flexibility to tailor the sensor properties to these applications. In this paper, the results of a numerical study are presented, showing that this flexibility is founded on the many degrees of freedom that can be used for the integrated optical chip design, in contrast to other technologies such as those based on surface plasmon resonance, for which the materials' properties limit the range of choices. The applications that are explicitly considered and discussed include (1) bulk refractometry, (2) thin-layer sensing, for example biosensors monitoring molecular adsorption processes occurring within some 10 nm of the chip's surface, (3) thick-layer sensing with processes involving molecules or ions to be monitored within a sensing matrix extending to some 100 nm from the chip's surface, for example hydrogel-based layers and chemo-optically sensitive membranes, and (4) particle sensing with particles or, for example, biological cells to be monitored within probe volumes extending to some 1,000 nm from the chip's surface. The peculiarities for the different types of applications will be discussed, and suitable modeling methods presented. Finally, the application-specific design guidelines supplied will enable the optimization of various types of integrated optical sensors, including interferometers and grating-based sensors.

  16. Integrated Tourism E-Commerce Platform for Scenery Administration Bureau, Travel Agency and Tourist

    Science.gov (United States)

    Liang, Zhixue; Wang, Shui

    Collaboration among multiple travel agencies and with scenery administration bureaus is vital for small or medium sized travel companies to succeed in the fierce competition of the tourism industry; business processes such as regrouping individual travelers between different agencies prove to be difficult and unpleasant user experience; tourists want to be more informed and have more initiative. To address these issues, proposes an integrated tourism e-commerce platform for travel agencies and scenery administration bureaus as well as tourists to interact in a more smooth way; this platform is constructed upon J2EE framework, provides online collaboration & coordination for companies and information services (such as self-navigation using Google Map etc) for tourists. A running implementation of this platform has been put into real business for a small travel company.

  17. Multi-octave spectral beam combiner on ultra-broadband photonic integrated circuit platform.

    Science.gov (United States)

    Stanton, Eric J; Heck, Martijn J R; Bovington, Jock; Spott, Alexander; Bowers, John E

    2015-05-01

    We present the design of a novel platform that is able to combine optical frequency bands spanning 4.2 octaves from ultraviolet to mid-wave infrared into a single, low M2 output waveguide. We present the design and realization of a key component in this platform that combines the wavelength bands of 350 nm - 1500 nm and 1500 nm - 6500 nm with demonstrated efficiency greater than 90% in near-infrared and mid-wave infrared. The multi-octave spectral beam combiner concept is realized using an integrated platform with silicon nitride waveguides and silicon waveguides. Simulated bandwidth is shown to be over four octaves, and measured bandwidth is shown over two octaves, limited by the availability of sources.

  18. Integrated method to optimize well connection and platform placement on a multi-reservoir scenario

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, Sergio Henrique Guerra de; Madeira, Marcelo Gomes; Franca, Martha Salles [Halliburton, Rio de Janeiro, RJ (Brazil); Mota, Rosane Oliveira; Silva, Edilon Ribeiro da; King, Vanessa Pereira Spear [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    This paper describes a workflow created to optimize the platform placement and well-platform connections on a multi reservoir scenario using an integrated reservoir simulator paired with an optimization engine. The proposed methodology describes how a new platform, being incorporated into a pre-existing asset, can be better used to develop newly-discovered fields, while helping increase the production of existing fields by sharing their production load. The sharing of production facilities is highly important in Brazilian offshore assets because of their high price (a few billion dollars per facility) and the fact that total production is usually limited to the installed capacity of liquid processing, which is an important constraint on high water-cut well production rates typical to this region. The case study asset used to present the workflow consists of two deep water oil fields, each one developed by its own production platform, and a newly-discovered field with strong aquifer support that will be entirely developed with a new production platform. Because this new field should not include injector wells owing to the strong aquifer presence, the idea is to consider reconnecting existing wells from the two pre-existing fields to better use the production resources. In this scenario, the platform location is an important optimization issue, as a balance between supporting the production of the planned wells on the new field and the production of re-routed wells from the existing fields must be reached to achieve improved overall asset production. If the new platform is too far away from any interconnected production well, pressure-drop issues along the pipeline might actually decrease production from the existing fields rather than augment it. The main contribution of this work is giving the reader insights on how to model and optimize these complex decisions to generate high-quality scenarios. (author)

  19. The business impact of an integrated continuous biomanufacturing platform for recombinant protein production.

    Science.gov (United States)

    Walther, Jason; Godawat, Rahul; Hwang, Chris; Abe, Yuki; Sinclair, Andrew; Konstantinov, Konstantin

    2015-11-10

    The biotechnology industry primarily uses batch technologies to manufacture recombinant proteins. The natural evolution of other industries has shown that transitioning from batch to continuous processing can yield significant benefits. A quantitative understanding of these benefits is critical to guide the implementation of continuous processing. In this manuscript, we use process economic modeling and Monte Carlo simulations to evaluate an integrated continuous biomanufacturing (ICB) platform and conduct risk-based valuation to generate a probabilistic range of net-present values (NPVs). For a specific ten-year product portfolio, the ICB platform reduces average cost by 55% compared to conventional batch processing, considering both capital and operating expenses. The model predicts that these savings can further increase by an additional 25% in situations with higher-than-expected product demand showing the upward potential of the ICB platform. The ICB platform achieves these savings and corresponding flexibility mainly due to process intensification in both upstream and downstream unit operations. This study demonstrates the promise of continuous bioprocessing while also establishing a novel framework to quantify financial benefits of other platform process technologies.

  20. Silicon-based optoelectronic integrated circuit for label-free bio/chemical sensor.

    Science.gov (United States)

    Song, Junfeng; Luo, Xianshu; Kee, Jack Sheng; Han, Kyungsup; Li, Chao; Park, Mi Kyoung; Tu, Xiaoguang; Zhang, Huijuan; Fang, Qing; Jia, Lianxi; Yoon, Yong-Jin; Liow, Tsung-Yang; Yu, Mingbin; Lo, Guo-Qiang

    2013-07-29

    We demonstrate a silicon-based optoelectronic integrated circuit (OEIC) for label-free bio/chemical sensing application. Such on-chip OEIC sensor system consists of optical grating couplers for vertical light coupling into silicon waveguides, a thermal-tunable microring as a tunable filter, an exposed microring as an optical label-free sensor, and a Ge photodetector for a direct electrical readout. Different from the conventional wavelength-scanning method, we adopt low-cost broadband ASE light source, together with the on-chip tunable filter to generate sliced light source. The effective refractive index change of the sensing microring induced by the sensing target is traced by scanning the supplied electrical power applied onto the tracing microring, and the detected electrical signal is read out by the Ge photodetector. For bulk refractive index sensing, we demonstrate using such OEIC sensing system with a sensitivity of ~15 mW/RIU and a detection limit of 3.9 μ-RIU, while for surface sensing of biotin-streptavidin, we obtain a surface mass sensitivity of S(m) = ~192 µW/ng·mm(-2) and a surface detection limit of 0.3 pg/mm(2). The presented OEIC sensing system is suitable for point-of-care applications.

  1. Unified Electronic Currency Based on the Fourth Party Platform Integrated Payment Service

    Science.gov (United States)

    Yong, Xu; Qiqi, Hu

    This paper presents a solution of unified e-currency based on the fourth party platform integrated payment service. The purpose of the paper is to solve the problem of distribution and resource-wasting caused by the lack of unified electronic currency, and to solve regulatory difficulties due to regulation size caused by a wide variety of e-currency. Methods: This article first analyzes the problems in the development of electronic money, and then proposes the concept of a unified electronic currency based on the fourth party platform integrated payment service. Besides, it proposes a unified mechanism and transaction procedures for unified e-currency, and analyzes the liquidation process, security and regulatory requirements, which are involved in using unified electronic currency.

  2. Integration Platform As Central Service Of Data Replication In Distributed Medical System

    Directory of Open Access Journals (Sweden)

    Wiesław Wajs

    2007-01-01

    Full Text Available The paper presents the application of Java Integration Platform (JIP to data replicationin the distributed medical system. After an introductory part on the medical system’s architecture,the focus shifts to a comparison of different approaches that exist with regard totransferring data between the system’s components. A description is given of the historicaldata processing and of the whole area of the JIP application to the medical system.

  3. Development of reactor configurations for an electrofuels platform utilizing genetically modified iron oxidizing bacteria for the reduction of CO2 to biochemicals.

    Science.gov (United States)

    Guan, Jingyang; Berlinger, Sarah A; Li, Xiaozheng; Chao, Zhongmou; Sousa E Silva, Victor; Banta, Scott; West, Alan C

    2017-03-10

    Electrofuels processes are potentially promising platforms for biochemical production from CO2 using renewable energy. When coupled to solar panels, this approach could avoid the inefficiencies of photosynthesis and there is no competition with food agriculture. In addition, these systems could potentially be used to store intermittent or stranded electricity generated from other renewable sources. Here we develop reactor configurations for continuous electrofuels processes to convert electricity and CO2 to isobutyric acid (IBA) using genetically modified (GM) chemolithoautotrophic Acidithiobacillus ferrooxidans. These cells oxidize ferrous iron which can be electrochemically reduced. During two weeks of cultivation on ferrous iron, stable cell growth and continuous IBA production from CO2 were achieved in a process where media was circulated between electrochemical and biochemical rectors. An alternative process with an additional electrochemical cell for accelerated ferrous production was developed, and this system achieved an almost three-fold increase in steady state cell densities, and an almost 4-fold increase in the ferrous iron oxidation rate. Combined, this led to an almost 8-fold increase in the steady state volumetric productivity of IBA up to 0.063±0.012mg/L/h, without a decline in energy efficiency from previous work. Continued development of reactor configurations which can increase the delivery of energy to the genetically modified cells will be required to increase product titers and volumetric productivities.

  4. An Integrated System for Disabled People Developed with the Agent Platform PANGEA

    Directory of Open Access Journals (Sweden)

    Carolina ZATO

    2013-11-01

    Full Text Available New trends in multi-agent systems call for self-adaptation and high dynamics, hence the new model of open MAS or virtual organization of agents. However, as existing agent platforms are not yet equipped to support this behavior, it is necessary to create new systems and mechanisms to facilitate the development of these new architectures. This article presents PANGEA, an agent platform to develop open multi-agent systems, specifically those including organizational aspects such as virtual agent organizations. The platform allows the integral management of organizations and offers tools to the end user. Additionally, it includes a communication protocol based on the IRC standard, which facilitates implementation and remains robust even with a large number of connections. The introduction of a CommunicationAgent and a Sniffer make it possible to offer Web Services for the distributed control of interaction. In order to test PANGEA, an integral system was developed to help the disabled, gathering a set of easily deployable and integrated services under a single architecture.

  5. SERVIR-Africa: Developing an Integrated Platform for Floods Disaster Management in Africa

    Science.gov (United States)

    Macharia, Daniel; Korme, Tesfaye; Policelli, Fritz; Irwin, Dan; Adler, Bob; Hong, Yang

    2010-01-01

    SERVIR-Africa is an ambitious regional visualization and monitoring system that integrates remotely sensed data with predictive models and field-based data to monitor ecological processes and respond to natural disasters. It aims addressing societal benefits including floods and turning data into actionable information for decision-makers. Floods are exogenous disasters that affect many parts of Africa, probably second only to drought in terms of social-economic losses. This paper looks at SERVIR-Africa's approach to floods disaster management through establishment of an integrated platform, floods prediction models, post-event flood mapping and monitoring as well as flood maps dissemination in support of flood disaster management.

  6. An Integrated microfluidic platform for liquid droplet in gas flow generation with in liquid flow collection and manipulation

    Science.gov (United States)

    Tirandazi, Pooyan; Hidrovo, Carlos H.

    2016-11-01

    Discretization of biological samples and chemical reactions within digital droplets is a powerful technique which has rapidly emerged in many biochemical syntheses. The ability to generate, manipulate, and monitor millions of microdroplets in a short time provides great potential for high throughput screening and detection in microbiology. Here we report a microfluidic device for the formation of uniform microdroplets (50 μm-100 μm) using a high speed gas as the continuous phase. Gas-borne droplets are generated in a chip-based flow-focusing device fabricated in PDMS, and travel along the gaseous microchannel and are subsequently captured within a second liquid phase. The droplets are then transferred and collected in a minichamber and move into the manipulation section for further processing operations on the drops. All these steps are performed automatically in a single multilayer chip. This integrated microfluidic platform for generation, collection, and manipulation of the droplets provides great opportunities for monitoring and detection of gas-analytes. Utilizing the generated picoliter airborne droplets feature lower reaction times and higher transfer rates as compared to conventional air sampling techniques. Thus, it can greatly facilitate the investigation of airborne analytes by interrogation of the digital droplets using different analytical techniques. Furthermore, the presented liquid-in-gas generation method can be utilized for production of oil-free microparticles and microcapsules used in the food industry and for drug delivery.

  7. Design of the Hospital Integrated Information Management System Based on Cloud Platform.

    Science.gov (United States)

    Aijing, L; Jin, Y

    2016-04-18

    At present, the outdated information management style cannot meet the needs of hospital management, and has become the bottleneck of hospital's management and development. In order to improve the integrated management of information, hospitals have increased their investment in integrated information management systems. On account of the lack of reasonable and scientific design, some hospital integrated information management systems have common problems, such as unfriendly interface, poor portability and maintainability, low security and efficiency, lack of interactivity and information sharing. To solve the problem, this paper carries out the research and design of a hospital information management system based on cloud platform, which can realize the optimized integration of hospital information resources and save money.

  8. Design of the Hospital Integrated Information Management System Based on Cloud Platform

    Science.gov (United States)

    Aijing, L; Jin, Y

    2015-01-01

    ABSTRACT At present, the outdated information management style cannot meet the needs of hospital management, and has become the bottleneck of hospital's management and development. In order to improve the integrated management of information, hospitals have increased their investment in integrated information management systems. On account of the lack of reasonable and scientific design, some hospital integrated information management systems have common problems, such as unfriendly interface, poor portability and maintainability, low security and efficiency, lack of interactivity and information sharing. To solve the problem, this paper carries out the research and design of a hospital information management system based on cloud platform, which can realize the optimized integration of hospital information resources and save money. PMID:27399033

  9. Insight: An ontology-based integrated database and analysis platform for epilepsy self-management research.

    Science.gov (United States)

    Sahoo, Satya S; Ramesh, Priya; Welter, Elisabeth; Bukach, Ashley; Valdez, Joshua; Tatsuoka, Curtis; Bamps, Yvan; Stoll, Shelley; Jobst, Barbara C; Sajatovic, Martha

    2016-10-01

    We present Insight as an integrated database and analysis platform for epilepsy self-management research as part of the national Managing Epilepsy Well Network. Insight is the only available informatics platform for accessing and analyzing integrated data from multiple epilepsy self-management research studies with several new data management features and user-friendly functionalities. The features of Insight include, (1) use of Common Data Elements defined by members of the research community and an epilepsy domain ontology for data integration and querying, (2) visualization tools to support real time exploration of data distribution across research studies, and (3) an interactive visual query interface for provenance-enabled research cohort identification. The Insight platform contains data from five completed epilepsy self-management research studies covering various categories of data, including depression, quality of life, seizure frequency, and socioeconomic information. The data represents over 400 participants with 7552 data points. The Insight data exploration and cohort identification query interface has been developed using Ruby on Rails Web technology and open source Web Ontology Language Application Programming Interface to support ontology-based reasoning. We have developed an efficient ontology management module that automatically updates the ontology mappings each time a new version of the Epilepsy and Seizure Ontology is released. The Insight platform features a Role-based Access Control module to authenticate and effectively manage user access to different research studies. User access to Insight is managed by the Managing Epilepsy Well Network database steering committee consisting of representatives of all current collaborating centers of the Managing Epilepsy Well Network. New research studies are being continuously added to the Insight database and the size as well as the unique coverage of the dataset allows investigators to conduct

  10. A platform for analysis of nanoscale liquids with an integrated sensor array based on 2-d material

    CERN Document Server

    Engel, M; Neumann, R F; Giro, R; Feger, C; Avouris, P; Steiner, M

    2016-01-01

    Analysis of nanoscale liquids, including wetting and flow phenomena, is a scientific challenge with far reaching implications for industrial technologies. We report the conception, development, and application of an integrated platform for the experimental characterization of liquids at the nanometer scale. The platform combines the sensing functionalities of an integrated, two-dimensional electronic device array with in situ application of highly sensitive optical micro-spectroscopy and atomic force microscopy. We demonstrate the performance capabilities of the platform with an embodiment based on an array of integrated, optically transparent graphene sensors. The application of electronic and optical sensing in the platform allows for differentiating between liquids electronically, for determining a liquid's molecular fingerprint, and for monitoring surface wetting dynamics in real time. In order to explore the platform's sensitivity limits, we record topographies and optical spectra of individual, spatiall...

  11. Integration of protein processing steps on a droplet microfluidics platform for MALDI-MS analysis.

    Science.gov (United States)

    Chatterjee, Debalina; Ytterberg, A Jimmy; Son, Sang Uk; Loo, Joseph A; Garrell, Robin L

    2010-03-01

    A droplet-based (digital) microfluidics platform has been developed to prepare and purify protein samples for measurement by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Liquid droplets are moved in air by sequentially applying an electric potential to an array of electrodes patterned beneath a hydrophobic dielectric layer. We show that a complete integrated sequence of protein processing steps can be performed on this platform, including disulfide reduction, alkylation, and enzymatic digestion, followed by cocrystallization with a MALDI matrix and analysis of the sample in situ by MALDI-MS. Proteins carbonic anhydrase, cytochrome c, and ubiquitin were used to demonstrate the digestion and postdigestion steps; insulin, serum albumin, and lysozyme were used to illustrate the complete sequence of protein processing steps available with the platform. Several functional improvements in the platform are reported, notably, the incorporation of acetonitrile in the protein droplets to facilitate movement, and patterning the device surfaces to optimize sample crystallization. The method is fast, simple, repeatable, and results in lower reagent consumption and sample loss than conventional techniques for proteomics sample preparation.

  12. Model Driven Architecture (MDA: Integration and Model Reuse for Open Source eLearning Platforms

    Directory of Open Access Journals (Sweden)

    Blasius Lofi Dewanto

    2005-02-01

    Full Text Available Open Source (OS community offers numerous eLearning platforms of both types: Learning Management Systems (LMS and Learning Content Systems (LCS. General purpose OS intermediaries such as SourceForge, ObjectWeb, Apache or specialized intermediaries like CampusSource reduce the cost to locate such eLearning platforms. Still, it is impossible to directly compare the functionalities of those OS software products without performing detailed testing on each product. Some articles available from eLearning Wikipedia show comparisons between eLearning platforms which can help, but at the end they barely serve as documentation which are becoming out of date quickly (1. The absence of integration activities between OS eLearning platforms - which are sometimes quite similar in terms of functionalities and implementation technologies - is sometimes critical since most of the OS projects possess small financial and human resources. This paper shows a possible solution for these barriers of OS eLearning platforms. We propose the Model Driven Architecture (MDA concept to capture functionalities and to identify similarities between available OS eLearning platforms. This contribution evolved from a fruitful discussion at the 2nd CampusSource Developer Conference at the University of Muenster (27th August 2004.Die Open Source-Community bietet zahlreiche eLearning-Plattformen an: Learning Management-Systeme (LMS sowie Learning Content-Systeme (LCS. Allgemeine Open-Source-Mediatoren, wie SourceForge, ObjectWeb, Apache und der eLearning-spezifische Mediator CampusSource ermöglichen eine einfache Suche nach eLearning-Softwareprodukten. Ein Vergleich unterschiedlicher Plattformen in Bezug auf ihre Funktionalitäten ist jedoch aufwändig. Beiträge aus der “eLearning Wikipedia” können kaum als Entscheidungsgrundlage genutzt werden, da sie schnell veraltet sind (1. Zudem fehlen derzeit Aktivitäten zur Integration von Open Source-eLearning-Plattformen, die oft

  13. An Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits.

    Science.gov (United States)

    Kim, So W; Gupta, Ravi; Lee, Seo H; Min, Cheol W; Agrawal, Ganesh K; Rakwal, Randeep; Kim, Jong B; Jo, Ick H; Park, Soo-Yun; Kim, Jae K; Kim, Young-Chang; Bang, Kyong H; Kim, Sun T

    2016-01-01

    Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. In this study, we used an integrated biochemical, proteomics, and metabolomics approach to look into the medicinal properties of ginseng fruits. DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] assays showed higher antioxidant activities in ginseng fruits than leaves or roots. Two-dimensional gel electrophoresis (2-DE) profiling of ginseng fruit proteins (cv. Cheongsun) showed more than 400 spots wherein a total of 81 protein spots were identified by mass spectrometry using NCBInr, UniRef, and an in-house developed RNAseq (59,251 protein sequences)-based databases. Gene ontology analysis showed that most of the identified proteins were related to the hydrolase (18%), oxidoreductase (16%), and ATP binding (15%) activities. Further, a comparative proteome analysis of four cultivars of ginseng fruits (cvs. Yunpoong, Gumpoong, Chunpoong, and Cheongsun) led to the identification of 22 differentially modulated protein spots. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 66 metabolites including amino acids, sugars, organic acids, phenolic acids, phytosterols, tocopherols, and policosanols were identified and quantified. Some of these are well known medicinal compounds and were not previously identified in ginseng. Interestingly, the concentration of almost all metabolites was higher in the Chunpoong and Gumpoong cultivars. Parallel comparison of the four cultivars also revealed higher amounts of the medicinal metabolites in Chunpoong and Gumpoong cultivars. Taken together, our results demonstrate that ginseng fruits are a rich source of medicinal compounds with potential beneficial health effects.

  14. AlGaN/AlN integrated photonics platform for the ultraviolet and visible spectral range.

    Science.gov (United States)

    Soltani, Mohammad; Soref, Richard; Palacios, Tomas; Englund, Dirk

    2016-10-31

    We analyze a photonic integrated circuit (PIC) platform comprised of a crystalline AlxGa1-xN optical guiding layer on an AlN substrate for the ultraviolet to visible (UV-vis) wavelength range. An Al composition of x~0.65 provides a refractive index difference of ~0.1 between AlxGa1-xN and AlN, and a small lattice mismatch (xGa1-xN/AlN interface. This small refractive index difference is beneficial at shorter wavelengths to avoid extra-small waveguide dimensions. The platform enables compact waveguides and bends with high field confinement in the wavelength range from 700 nm down to 300 nm (and potentially lower) with waveguide cross-section dimensions comparable to those used for telecom PICs such as silicon and silicon nitride waveguides, allowing for well-established optical lithography. This platform can potentially enable cost-effective, manufacturable, monolithic UV-vis photonic integrated circuits.

  15. MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data

    Directory of Open Access Journals (Sweden)

    Ng Raymond T

    2008-05-01

    Full Text Available Abstract Background Recent advances in global genomic profiling methodologies have enabled multi-dimensional characterization of biological systems. Complete analysis of these genomic profiles require an in depth look at parallel profiles of segmental DNA copy number status, DNA methylation state, single nucleotide polymorphisms, as well as gene expression profiles. Due to the differences in data types it is difficult to conduct parallel analysis of multiple datasets from diverse platforms. Results To address this issue, we have developed an integrative genomic analysis platform MD-SeeGH, a software tool that allows users to rapidly and directly analyze genomic datasets spanning multiple genomic experiments. With MD-SeeGH, users have the flexibility to easily update datasets in accordance with new genomic builds, make a quality assessment of data using the filtering features, and identify genetic alterations within single or across multiple experiments. Multiple sample analysis in MD-SeeGH allows users to compare profiles from many experiments alongside tracks containing detailed localized gene information, microRNA, CpG islands, and copy number variations. Conclusion MD-SeeGH is a new platform for the integrative analysis of diverse microarray data, facilitating multiple profile analyses and group comparisons.

  16. Information Integration Platform for Patient-Centric Healthcare Services: Design, Prototype and Dependability Aspects

    Directory of Open Access Journals (Sweden)

    Yohanes Baptista Dafferianto Trinugroho

    2014-03-01

    Full Text Available Technology innovations have pushed today’s healthcare sector to an unprecedented new level. Various portable and wearable medical and fitness devices are being sold in the consumer market to provide the self-empowerment of a healthier lifestyle to society. Many vendors provide additional cloud-based services for devices they manufacture, enabling the users to visualize, store and share the gathered information through the Internet. However, most of these services are integrated with the devices in a closed “silo” manner, where the devices can only be used with the provided services. To tackle this issue, an information integration platform (IIP has been developed to support communications between devices and Internet-based services in an event-driven fashion by adopting service-oriented architecture (SOA principles and a publish/subscribe messaging pattern. It follows the “Internet of Things” (IoT idea of connecting everyday objects to various networks and to enable the dissemination of the gathered information to the global information space through the Internet. A patient-centric healthcare service environment is chosen as the target scenario for the deployment of the platform, as this is a domain where IoT can have a direct positive impact on quality of life enhancement. This paper describes the developed platform, with emphasis on dependability aspects, including availability, scalability and security.

  17. An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures

    Directory of Open Access Journals (Sweden)

    Sherwin Ting

    2014-09-01

    In conclusion, we have developed a simple robust and scalable platform that integrates both hESC expansion and CM differentiation in one unit process which is capable of meeting the need for large amounts of CMs.

  18. A microsystem integration platform dedicated to build multi-chip-neural interfaces.

    Science.gov (United States)

    Ayoub, Amer E; Gosselin, Benoit; Sawan, Mohamad

    2007-01-01

    In this paper, we present an electrical discharge machining (EDM) technique associated with electrochemical steps to construct an appropriate biological interface to neural tissues. The presented microprobe design permits to short the time of production compared to available techniques, while improving the integrity of the electrodes. In addition, we are using a 3D approach to create compact and independent microsystem integration platefrom incorporating array of electrodes and signal processing chips. System-in-package and die-stacking are used to connect the integrated circuits and the array of electrodes on the platform. This approach enables to build a device that will fit in a volume smaller than 1.7 x 1.7 x 3.0 mm(3). This demonstrates the possibility of creating small devices that are suitable to fit in restricted areas for interfacing the brain.

  19. Integrated opto-microfluidics platforms in lithium niobate crystals for sensing applications

    Science.gov (United States)

    Bettella, G.; Pozza, G.; Zaltron, A.; Ciampolillo, M. V.; Argiolas, N.; Sada, C.; Chauvet, M.; Guichardaz, B.

    2015-02-01

    In micro-analytical chemistry and biology applications, droplet microfluidic technology holds great promise for efficient lab-on-chip systems where higher levels of integration of different stages on the same platform is constantly addressed. The possibility of integration of opto-microfluidic functionalities in lithium niobate (LiNbO3) crystals is presented. Microfluidic channels were directly engraved in a LiNbO3 substrate by precision saw cutting, and illuminated by optical waveguides integrated on the same substrate. The morphological characterization of the microfluidic channel and the optical response of the coupled optical waveguide were tested. In particular, the results indicate that the optical properties of the constituents dispersed in the fluid flowing in the microfluidic channel can be monitored in situ, opening to new compact optical sensor prototypes based on droplets generation and optical analysis of the relative constituents.

  20. Supporting Building Portfolio Investment and Policy Decision Making through an Integrated Building Utility Data Platform

    Energy Technology Data Exchange (ETDEWEB)

    Aziz, Azizan [Carnegie Mellon Univ., Pittsburgh, PA (United States); Lasternas, Bertrand [Carnegie Mellon Univ., Pittsburgh, PA (United States); Alschuler, Elena [US DOE; View Inc; Loftness, Vivian [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Haopeng [Carnegie Mellon Univ., Pittsburgh, PA (United States); Mo, Yunjeong [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Ting [Carnegie Mellon Univ., Pittsburgh, PA (United States); Zhang, Chenlu [Carnegie Mellon Univ., Pittsburgh, PA (United States); Sharma, Shilpi [Carnegie Mellon; Stevens, Ivana [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-03-18

    The American Recovery and Reinvestment Act stimulus funding of 2009 for smart grid projects resulted in the tripling of smart meters deployment. In 2012, the Green Button initiative provided utility customers with access to their real-time1 energy usage. The availability of finely granular data provides an enormous potential for energy data analytics and energy benchmarking. The sheer volume of time-series utility data from a large number of buildings also poses challenges in data collection, quality control, and database management for rigorous and meaningful analyses. In this paper, we will describe a building portfolio-level data analytics tool for operational optimization, business investment and policy assessment using 15-minute to monthly intervals utility data. The analytics tool is developed on top of the U.S. Department of Energy’s Standard Energy Efficiency Data (SEED) platform, an open source software application that manages energy performance data of large groups of buildings. To support the significantly large volume of granular interval data, we integrated a parallel time-series database to the existing relational database. The time-series database improves on the current utility data input, focusing on real-time data collection, storage, analytics and data quality control. The fully integrated data platform supports APIs for utility apps development by third party software developers. These apps will provide actionable intelligence for building owners and facilities managers. Unlike a commercial system, this platform is an open source platform funded by the U.S. Government, accessible to the public, researchers and other developers, to support initiatives in reducing building energy consumption.

  1. MAID : An effect size based model for microarray data integration across laboratories and platforms

    Directory of Open Access Journals (Sweden)

    Edwards Aled M

    2008-07-01

    Full Text Available Abstract Background Gene expression profiling has the potential to unravel molecular mechanisms behind gene regulation and identify gene targets for therapeutic interventions. As microarray technology matures, the number of microarray studies has increased, resulting in many different datasets available for any given disease. The increase in sensitivity and reliability of measurements of gene expression changes can be improved through a systematic integration of different microarray datasets that address the same or similar biological questions. Results Traditional effect size models can not be used to integrate array data that directly compare treatment to control samples expressed as log ratios of gene expressions. Here we extend the traditional effect size model to integrate as many array datasets as possible. The extended effect size model (MAID can integrate any array datatype generated with either single or two channel arrays using either direct or indirect designs across different laboratories and platforms. The model uses two standardized indices, the standard effect size score for experiments with two groups of data, and a new standardized index that measures the difference in gene expression between treatment and control groups for one sample data with replicate arrays. The statistical significance of treatment effect across studies for each gene is determined by appropriate permutation methods depending on the type of data integrated. We apply our method to three different expression datasets from two different laboratories generated using three different array platforms and two different experimental designs. Our results indicate that the proposed integration model produces an increase in statistical power for identifying differentially expressed genes when integrating data across experiments and when compared to other integration models. We also show that genes found to be significant using our data integration method are of direct

  2. Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling.

    Science.gov (United States)

    Shang, Yuqin; Zeng, Yun; Zeng, Yong

    2016-02-02

    Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges in analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and speed of lectin microarray. Moreover, we established an on-chip lectin assay which employs a very simple blocking method to effectively suppress the undesired background due to lectin binding of antibodies. Using this technology, we demonstrated focused differential profiling of tissue-specific glycosylation changes of a biomarker, CA125 protein purified from ovarian cancer cell line and different tissues from ovarian cancer patients in a fast, reproducible, and high-throughput fashion. Highly sensitive CA125 detection was also demonstrated with a detection limit much lower than the clinical cutoff value for cancer diagnosis. This microfluidic platform holds the potential to integrate with sample preparation functions to construct a fully integrated "sample-to-answer" microsystem for focused differential glycomic analysis. Thus, our technology should present a powerful tool in support of rapid advance in glycobiology and glyco-biomarker development.

  3. Micromanipulation of InP lasers with optoelectronic tweezers for integration on a photonic platform.

    Science.gov (United States)

    Juvert, Joan; Zhang, Shuailong; Eddie, Iain; Mitchell, Colin J; Reed, Graham T; Wilkinson, James S; Kelly, Anthony; Neale, Steven L

    2016-08-08

    The integration of light sources on a photonic platform is a key aspect of the fabrication of self-contained photonic circuits with a small footprint that does not have a definitive solution yet. Several approaches are being actively researched for this purpose. In this work we propose optoelectronic tweezers for the manipulation and integration of light sources on a photonic platform and report the positional and angular accuracy of the micromanipulation of standard Fabry-Pérot InP semiconductor laser die. These lasers are over three orders of magnitude bigger in volume than any previously assembled with optofluidic techniques and the fact that they are industry standard lasers makes them significantly more useful than previously assembled microdisk lasers. We measure the accuracy to be 2.5 ± 1.4 µm and 1.4 ± 0.4° and conclude that optoelectronic tweezers are a promising technique for the micromanipulation and integration of optoelectronic components in general and semiconductor lasers in particular.

  4. Integration and Testing of Miniaturized Volcanic Gas-Sensing Instruments on UAS Platforms

    Science.gov (United States)

    Lopez, T. M.; Kern, C.; Diaz, J. A.; Vanderwaal, S. J.; Levy, A.

    2015-12-01

    Volcanologists measure the concentrations and emission rates of gases emitted from active volcanoes to understand magmatic processes, which aids in eruption forecasting, and to evaluate air quality for human and environmental health. Both of these applications become particularly important during periods of unusually high volcanic unrest when it is typically hazardous to approach a given volcano. Unmanned aerial systems (UASs) represent a promising platform for continued gas measurements during unrest, while reducing the risk to volcanologists. Two miniature gas-sensing instruments have been developed specifically for integration onto small UAS platforms. Both instruments weigh 1 kg or less, including integrated power. The microDOAS instrument is an upward-looking UV/vis spectrometer that measures the spectral absorption signature of SO2 and certain halogen oxides in scattered solar radiation. By flying beneath a volcanic plume, the instrument can measure the SO2 content in the plume cross-section which can be used to determine the SO2 emission rate. The miniGas instrument is flown within the volcanic plume and records in situ concentrations of CO2, SO2 and H2S, as well as atmospheric temperature, pressure, relative humidity and GPS location. All data are telemetered back to the base station to immediately alert the operator of potentially hazardous conditions. Both instruments have been successfully tested at active volcanoes in Alaska and Costa Rica and were integrated onto small ACUASI Ptarmigan hexacopters. A test mission was conducted at the Poker Flat Research Range in Alaska. During this experiment both instruments were successfully flown in flight patterns typical of manned volcanic gas measurements and new UAV-specific measurement strategies were developed. Here we describe the instruments and platforms employed, our experimental results and observations, and make recommendations for application to volcanic settings.

  5. Progress in Open-World, Integrative, Collaborative Science Data Platforms (Invited)

    Science.gov (United States)

    Fox, P. A.

    2013-12-01

    As collaborative, or network science spreads into more Earth and space science fields, both the participants and their funders have expressed a very strong desire for highly functional data and information capabilities that are a) easy to use, b) integrated in a variety of ways, c) leverage prior investments and keep pace with rapid technical change, and d) are not expensive or time-consuming to build or maintain. In response, and based on our accumulated experience over the last decade and a maturing of several key technical approaches, we have adapted, extended, and integrated several open source applications and frameworks that handle major portions of functionality for these platforms. At minimum, these functions include: an object-type repository, collaboration tools, an ability to identify and manage all key entities in the platform, and an integrated portal to manage diverse content and applications, with varied access levels and privacy options. At a conceptual level, science networks (even small ones) deal with people, and many intellectual artifacts produced or consumed in research, organizational and/our outreach activities, as well as the relations among them. Increasingly these networks are modeled as knowledge networks, i.e. graphs with named and typed relations among the 'nodes'. Nodes can be people, organizations, datasets, events, presentations, publications, videos, meetings, reports, groups, and more. In this heterogeneous ecosystem, it is also important to use a set of common informatics approaches to co-design and co-evolve the needed science data platforms based on what real people want to use them for. In this contribution, we present our methods and results for information modeling, adapting, integrating and evolving a networked data science and information architecture based on several open source technologies (Drupal, VIVO, the Comprehensive Knowledge Archive Network; CKAN, and the Global Handle System; GHS). In particular we present both

  6. Quality control of next-generation sequencing library through an integrative digital microfluidic platform.

    Science.gov (United States)

    Thaitrong, Numrin; Kim, Hanyoup; Renzi, Ronald F; Bartsch, Michael S; Meagher, Robert J; Patel, Kamlesh D

    2012-12-01

    We have developed an automated quality control (QC) platform for next-generation sequencing (NGS) library characterization by integrating a droplet-based digital microfluidic (DMF) system with a capillary-based reagent delivery unit and a quantitative CE module. Using an in-plane capillary-DMF interface, a prepared sample droplet was actuated into position between the ground electrode and the inlet of the separation capillary to complete the circuit for an electrokinetic injection. Using a DNA ladder as an internal standard, the CE module with a compact LIF detector was capable of detecting dsDNA in the range of 5-100 pg/μL, suitable for the amount of DNA required by the Illumina Genome Analyzer sequencing platform. This DMF-CE platform consumes tenfold less sample volume than the current Agilent BioAnalyzer QC technique, preserving precious sample while providing necessary sensitivity and accuracy for optimal sequencing performance. The ability of this microfluidic system to validate NGS library preparation was demonstrated by examining the effects of limited-cycle PCR amplification on the size distribution and the yield of Illumina-compatible libraries, demonstrating that as few as ten cycles of PCR bias the size distribution of the library toward undesirable larger fragments.

  7. Massively Parallel, Molecular Analysis Platform Developed Using a CMOS Integrated Circuit With Biological Nanopores

    Science.gov (United States)

    Roever, Stefan

    2012-01-01

    A massively parallel, low cost molecular analysis platform will dramatically change the nature of protein, molecular and genomics research, DNA sequencing, and ultimately, molecular diagnostics. An integrated circuit (IC) with 264 sensors was fabricated using standard CMOS semiconductor processing technology. Each of these sensors is individually controlled with precision analog circuitry and is capable of single molecule measurements. Under electronic and software control, the IC was used to demonstrate the feasibility of creating and detecting lipid bilayers and biological nanopores using wild type α-hemolysin. The ability to dynamically create bilayers over each of the sensors will greatly accelerate pore development and pore mutation analysis. In addition, the noise performance of the IC was measured to be 30fA(rms). With this noise performance, single base detection of DNA was demonstrated using α-hemolysin. The data shows that a single molecule, electrical detection platform using biological nanopores can be operationalized and can ultimately scale to millions of sensors. Such a massively parallel platform will revolutionize molecular analysis and will completely change the field of molecular diagnostics in the future.

  8. Miniaturized Integrated Platform for Electrical and Optical Monitoring of Cell Cultures

    Directory of Open Access Journals (Sweden)

    Costin Brasoveanu

    2012-08-01

    Full Text Available The following paper describes the design and functions of a miniaturized integrated platform for optical and electrical monitoring of cell cultures and the necessary steps in the fabrication and testing of a silicon microchip Micro ElectroMechanical Systems (MEMS-based technology for cell data recording, monitoring and stimulation. The silicon microchip consists of a MEMS machined device containing a shank of 240 μm width, 3 mm long and 50 μm thick and an enlarged area of 5 mm × 5 mm hosting the pads for electrical connections. Ten platinum electrodes and five sensors are placed on the shank and are connected with the external electronics through the pads. The sensors aim to monitor the pH, the temperature and the impedance of the cell culture. The electrodes are bidirectional and can be used both for electrical potential recording and stimulation of cells. The fabrication steps are presented, along with the electrical and optical characterization of the system. The target of the research is to develop a new and reconfigurable platform according to the particular applications needs, as a tool for the biologist, chemists and medical doctors working is the field of cell culture monitoring in terms of growth, maintenance conditions, reaction to electrical or chemical stimulation (drugs, toxicants, etc.. HaCaT (Immortalised Human Keratinocyte cell culture has been used for demonstration purposes in order to provide information on the platform electrical and optical functions.

  9. Using a blog as an integrated eLearning tool and platform.

    Science.gov (United States)

    Goh, Poh Sun

    2016-06-01

    Technology enhanced learning or eLearning allows educators to expand access to educational content, promotes engagement with students and makes it easier for students to access educational material at a time, place and pace which suits them. The challenge for educators beginning their eLearning journey is to decide where to start, which includes the choice of an eLearning tool and platform. This article will share one educator's decision making process, and experience using blogs as a flexible and versatile integrated eLearning tool and platform. Apart from being a cost effective/free tool and platform, blogs offer the possibility of creating a hyperlinked indexed content repository, for both created and curated educational material; as well as a distribution and engagement tool and platform. Incorporating pedagogically sound activities and educational practices into a blog promote a structured templated teaching process, which can be reproduced. Moving from undergraduate to postgraduate training, educational blogs supported by a comprehensive online case-based repository offer the possibility of training beyond competency towards proficiency and expert level performance through a process of deliberate practice. By documenting educational content and the student engagement and learning process, as well as feedback and personal reflection of educational sessions, blogs can also form the basis for a teaching portfolio, and provide evidence and data of scholarly teaching and educational scholarship. Looking into the future, having a collection of readily accessible indexed hyperlinked teaching material offers the potential to do on the spot teaching with illustrative material called up onto smart surfaces, and displayed on holographic interfaces.

  10. Integrated FBG sensors interrogator in silicon photonic platform using active interferometer monitoring

    Science.gov (United States)

    Marin, Y. E.; Nannipieri, T.; Di Pasquale, F.; Oton, C. J.

    2016-05-01

    We experimentally demonstrate the feasibility of Fiber Bragg Grating sensors interrogation using integrated unbalanced Mach-Zehnder Interferometers (MZI) and phase sensitive detection in silicon-on-insulator (SOI) platform. The Phase- Generated Carrier (PGC) demodulation technique is used to detect phase changes, avoiding signal fading. Signal processing allows us to extract the wavelength shift from the signal patterns, allowing accurate dynamic FBG interrogation. High resolution and low cost chips with multiple interrogators and photodetectors on board can be realized by exploiting the advantages of large scale fabrication capabilities of well-established silicon based industrial infrastructures. Simultaneous dynamic reading of a large number of FBG sensors can lead to large volume market applications of the technology in several strategic industrial fields. The performance of the proposed integrated FBG interrogator is validated by comparing with a commercial FBG readout based on a spectrometer and used as a reference.

  11. An integrated bioanalytical platform for supporting high-throughput serum protein binding screening.

    Science.gov (United States)

    Zhang, Jun; Shou, Wilson Z; Vath, Marianne; Kieltyka, Kasia; Maloney, Jennifer; Elvebak, Larry; Stewart, Jeremy; Herbst, John; Weller, Harold N

    2010-12-30

    Quantification of small molecules using liquid chromatography/tandem mass spectrometry (LC/MS/MS) on a triple quadrupole mass spectrometer has become a common practice in bioanalytical support of in vitro adsorption, distribution, metabolism and excretion (ADME) screening. The bioanalysis process involves primarily three indispensable steps: MS/MS optimization for a large number of new chemical compounds undergoing various screening assays in early drug discovery, high-throughput sample analysis with LC/MS/MS for those chemically diverse compounds using the optimized MS/MS conditions, and post-acquisition data review and reporting. To improve overall efficiency of ADME bioanalysis, an integrated system was proposed featuring an automated and unattended MS/MS optimization, a staggered parallel LC/MS/MS for high-throughput sample analysis, and a sophisticated software tool for LC/MS/MS raw data review as well as biological data calculation and reporting. The integrated platform has been used in bioanalytical support of a serum protein binding screening assay with high speed, high capacity, and good robustness. In this new platform, a unique sample dilution scheme was also introduced. With this dilution design, the total number of analytical samples was reduced; therefore, the total operation time was reduced and the overall throughput was further improved. The performance of the protein binding screening assay was monitored with two controls representing high and low binding properties and an acceptable inter-assay consistency was achieved. This platform has been successfully used for the determination of serum protein binding in multiple species for more than 4000 compounds.

  12. An integrated microfluidic platform for rapid tumor cell isolation, counting and molecular diagnosis.

    Science.gov (United States)

    Hung, Lien-Yu; Chuang, Ying-Hsin; Kuo, Hsin-Tzu; Wang, Chih-Hung; Hsu, Keng-Fu; Chou, Cheng-Yang; Lee, Gwo-Bin

    2013-04-01

    Ovarian cancer is the second most common of the gynecological cancers in Taiwan. It is challenging to diagnose at an early stage when proper treatment is the most effective. It is well recognized that the detection of tumor cells (TCs) is critical for determining cancer growth stages and may provide important information for accurate diagnosis and even prognosis. In this study, a new microfluidic platform integrated with a moving-wall micro-incubator, a micro flow cytometer and a molecular diagnosis module performed automated identification of ovarian cancer cells. By efficiently mixing the cells and immunomagnetic beads coated with specific antibodies, the target TCs were successfully isolated from the clinical samples. Then counting of the target cells was achieved by a combination of the micro flow cytometer and an optical detection module and showed a counting accuracy as high as 92.5 %. Finally, cancer-associated genes were amplified and detected by the downstream molecular diagnosis module. The fluorescence intensity of specific genes (CD24 and HE4) associated with ovarian cancer was amplified by the molecular diagnosis module and the results were comparable to traditional slab-gel electrophoresis analysis, with a limit of detection around 10 TCs. This integrated microfluidic platform realized the concept of a "lab-on-a-chip" and had advantages which included automation, disposability, lower cost and rapid diagnosis and, therefore, may provide a promising approach for the fast and accurate detection of cancer cells.

  13. An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Gabriela Furlan [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Vieira, Luis Carlos Silveira; Gobbi, Angelo Luiz [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Lima, Renato Sousa [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Kubota, Lauro Tatsuo, E-mail: kubota@iqm.unicamp.br [Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil)

    2015-05-22

    Highlights: • Integrated platform was developed to determine ethanol in fermentation broths. • The designed system integrates gas diffusion separation with voltammetric detection. • Detector relied on Ni(OH){sub 2}-modified electrode stabilized by Co{sup 2+} and Cd{sup 2+} insertion. • Separation was made by PTFE membrane separating sample from electrolyte (receptor). • Despite the sample complexity, accurate tests were achieved by direct interpolation. - Abstract: An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module. The detector relied on a Ni(OH){sub 2}-modified electrode. It was stabilized by uniformly depositing cobalt and cadmium hydroxides as shown by XPS measurements. Such tests were in accordance with the hypothesis related to stabilization of the Ni(OH){sub 2} structure by insertion of Co{sup 2+} and Cd{sup 2+} ions in this structure. The separation step, in turn, was based on a hydrophobic PTFE membrane, which separates the sample from receptor solution (electrolyte) where the electrodes were placed. Parameters of limit of detection and analytical sensitivity were estimated to be 0.2% v/v and 2.90 μA % (v/v){sup −1}, respectively. Samples of fermentation broth were analyzed by both standard addition method and direct interpolation in saline medium based-analytical curve. In this case, the saline solution exhibited ionic strength similar to those of the samples intended to surpass the tonometry colligative effect of the samples over analyte concentration data by attributing the reduction in quantity of diffused ethanol vapor majorly to the electrolyte. The approach of analytical curve provided rapid, simple and accurate

  14. Integrated Semantics Service Platform for the Internet of Things: A Case Study of a Smart Office

    Directory of Open Access Journals (Sweden)

    Minwoo Ryu

    2015-01-01

    Full Text Available The Internet of Things (IoT allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  15. Integrated semantics service platform for the Internet of Things: a case study of a smart office.

    Science.gov (United States)

    Ryu, Minwoo; Kim, Jaeho; Yun, Jaeseok

    2015-01-19

    The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.

  16. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

    OpenAIRE

    Vunjak-Novakovic, Gordana; Bhatia, Sangeeta; Chen, Christopher; Hirschi, Karen

    2010-01-01

    Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over ...

  17. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

    OpenAIRE

    Vunjak-Novakovic, Gordana; Bhatia, Sangeeta; Chen, Christopher; Hirschi, Karen

    2013-01-01

    Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over ...

  18. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.

    Science.gov (United States)

    Vunjak-Novakovic, Gordana; Bhatia, Sangeeta; Chen, Christopher; Hirschi, Karen

    2013-01-01

    Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

  19. An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology.

    Science.gov (United States)

    Taylor, Donald P

    2007-01-01

    High content screening (HCS) requires time-consuming and often complex iterative information retrieval and assessment approaches to optimally conduct drug discovery programs and biomedical research. Pre- and post-HCS experimentation both require the retrieval of information from public as well as proprietary literature in addition to structured information assets such as compound libraries and projects databases. Unfortunately, this information is typically scattered across a plethora of proprietary bioinformatics tools and databases and public domain sources. Consequently, single search requests must be presented to each information repository, forcing the results to be manually integrated for a meaningful result set. Furthermore, these bioinformatics tools and data repositories are becoming increasingly complex to use; typically they fail to allow for more natural query interfaces. Vivisimo has developed an enterprise software platform to bridge disparate silos of information. The platform automatically categorizes search results into descriptive folders without the use of taxonomies to drive the categorization. A new approach to information retrieval for HCS experimentation is proposed.

  20. Optical Beam Deflection Based AFM with Integrated Hardware and Software Platform for an Undergraduate Engineering Laboratory

    Directory of Open Access Journals (Sweden)

    Siu Hong Loh

    2017-02-01

    Full Text Available Atomic force microscopy (AFM has been used extensively in nanoscience research since its invention. Recently, many teaching laboratories in colleges, undergraduate institutions, and even high schools incorporate AFM as an effective teaching tool for nanoscience education. This paper presents an optical beam deflection (OBD based atomic force microscope, designed specifically for the undergraduate engineering laboratory as a teaching instrument. An electronic module for signal conditioning was built with components that are commonly available in an undergraduate electronic laboratory. In addition to off-the-shelf mechanical parts and optics, the design of custom-built mechanical parts waskept as simple as possible. Hence, the overall cost for the setup is greatly reduced. The AFM controller was developed using National Instruments Educational Laboratory Virtual Instrumentation Suite (NI ELVIS, an integrated hardware and software platform which can be programmed in LabVIEW. A simple yet effective control algorithm for scanning and feedback control was developed. Despite the use of an educational platform and low-cost components from the undergraduate laboratory, the developed AFM is capable of performing imaging in constant-force mode with submicron resolution and at reasonable scanning speed (approximately 18 min per image. Therefore, the AFM is suitable to be used as an educational tool for nanoscience. Moreover, the construction of the system can be a valuable educational experience for electronic and mechanical engineering students.

  1. Integrated plasmonic circuitry on a vertical-cavity surface-emitting semiconductor laser platform

    Science.gov (United States)

    McPolin, Cillian P. T.; Bouillard, Jean-Sebastien; Vilain, Sebastien; Krasavin, Alexey V.; Dickson, Wayne; O'Connor, Daniel; Wurtz, Gregory A.; Justice, John; Corbett, Brian; Zayats, Anatoly V.

    2016-08-01

    Integrated plasmonic sources and detectors are imperative in the practical development of plasmonic circuitry for bio- and chemical sensing, nanoscale optical information processing, as well as transducers for high-density optical data storage. Here we show that vertical-cavity surface-emitting lasers (VCSELs) can be employed as an on-chip, electrically pumped source or detector of plasmonic signals, when operated in forward or reverse bias, respectively. To this end, we experimentally demonstrate surface plasmon polariton excitation, waveguiding, frequency conversion and detection on a VCSEL-based plasmonic platform. The coupling efficiency of the VCSEL emission to waveguided surface plasmon polariton modes has been optimized using asymmetric plasmonic nanostructures. The plasmonic VCSEL platform validated here is a viable solution for practical realizations of plasmonic functionalities for various applications, such as those requiring sub-wavelength field confinement, refractive index sensitivity or optical near-field transduction with electrically driven sources, thus enabling the realization of on-chip optical communication and lab-on-a-chip devices.

  2. IMGD: an integrated platform supporting comparative genomics and phylogenetics of insect mitochondrial genomes

    Directory of Open Access Journals (Sweden)

    Jung Kyongyong

    2009-04-01

    Full Text Available Abstract Background Sequences and organization of the mitochondrial genome have been used as markers to investigate evolutionary history and relationships in many taxonomic groups. The rapidly increasing mitochondrial genome sequences from diverse insects provide ample opportunities to explore various global evolutionary questions in the superclass Hexapoda. To adequately support such questions, it is imperative to establish an informatics platform that facilitates the retrieval and utilization of available mitochondrial genome sequence data. Results The Insect Mitochondrial Genome Database (IMGD is a new integrated platform that archives the mitochondrial genome sequences from 25,747 hexapod species, including 112 completely sequenced and 20 nearly completed genomes and 113,985 partially sequenced mitochondrial genomes. The Species-driven User Interface (SUI of IMGD supports data retrieval and diverse analyses at multi-taxon levels. The Phyloviewer implemented in IMGD provides three methods for drawing phylogenetic trees and displays the resulting trees on the web. The SNP database incorporated to IMGD presents the distribution of SNPs and INDELs in the mitochondrial genomes of multiple isolates within eight species. A newly developed comparative SNU Genome Browser supports the graphical presentation and interactive interface for the identified SNPs/INDELs. Conclusion The IMGD provides a solid foundation for the comparative mitochondrial genomics and phylogenetics of insects. All data and functions described here are available at the web site http://www.imgd.org/.

  3. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

    Science.gov (United States)

    Hosoya, Hitomi; Dobroff, Andrey S; Driessen, Wouter H P; Cristini, Vittorio; Brinker, Lina M; Staquicini, Fernanda I; Cardó-Vila, Marina; D'Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; Lin, Yu-Shen; Dunphy, Darren R; Dogra, Prashant; Melancon, Marites P; Stafford, R Jason; Miyazono, Kohei; Gelovani, Juri G; Kataoka, Kazunori; Brinker, C Jeffrey; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata

    2016-02-16

    A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.

  4. New silicon photonics integration platform enabled by novel micron-scale bends

    CERN Document Server

    Cherchi, Matteo; Harjanne, Mikko; Kapulainen, Markku; Aalto, Timo

    2013-01-01

    Even though submicron silicon waveguides have been proposed for dense integration of photonic devices, to date the lightwave circuits on the market mainly rely on waveguides with micron-scale core dimensions. These larger waveguides feature easier fabrication, higher reliability and better interfacing to optical fibres. Single-mode operation with large core dimensions is obtained with low lateral refractive index contrast. Hence, the main limitation in increasing the level of integration and in reducing the cost of micron-scale waveguide circuits is their mm- to cm-scale minimum bending radius. Fortunately, single-mode rib waveguides with a micron-scale silicon core can be locally transformed into multi-mode strip waveguides that have very high lateral index contrast. Here we show how Euler spiral bends realized with these waveguides can have bending radii below 10 {\\mu}m and losses below 0.02 dB/90{\\deg} for the fundamental mode, paving way for a novel densely integrated platform based on micron-scale wavegu...

  5. Integration of biostatistics and pharmacometrics computing platforms for efficient and reproducible PK/PD analysis: a case study.

    Science.gov (United States)

    Ou, Ying C; Lo, Arthur; Lee, Brian; Liu, Phillip; Kimura, Karen; Eary, Charisse; Hopkins, Alan

    2013-11-01

    Results of pharmacometric analyses influence high-level decisions such as clinical trial design, drug approval, and labeling. Key challenges for timely delivery of pharmacometric analyses are the data assembly process and tracking and documenting the modeling process and results. Since clinical efficacy and safety data typically reside in the biostatistics computing area, an integrated computing platform for pharmacometric and biostatistical analyses would be ideal. A case study is presented integrating a pharmacometric modeling platform into an existing statistical computing environment (SCE). The feasibility and specific configurations of running common PK/PD programs such as NONMEM and R inside of the SCE are provided. The case study provides an example of an integrated repository that facilitates efficient data assembly for pharmacometrics analyses. The proposed platform encourages a good pharmacometrics working practice to maintain transparency, traceability, and reproducibility of PK/PD models and associated data in supporting drug development and regulatory decisions.

  6. Applications integration in a hybrid cloud computing environment: modelling and platform

    Science.gov (United States)

    Li, Qing; Wang, Ze-yuan; Li, Wei-hua; Li, Jun; Wang, Cheng; Du, Rui-yang

    2013-08-01

    With the development of application services providers and cloud computing, more and more small- and medium-sized business enterprises use software services and even infrastructure services provided by professional information service companies to replace all or part of their information systems (ISs). These information service companies provide applications, such as data storage, computing processes, document sharing and even management information system services as public resources to support the business process management of their customers. However, no cloud computing service vendor can satisfy the full functional IS requirements of an enterprise. As a result, enterprises often have to simultaneously use systems distributed in different clouds and their intra enterprise ISs. Thus, this article presents a framework to integrate applications deployed in public clouds and intra ISs. A run-time platform is developed and a cross-computing environment process modelling technique is also developed to improve the feasibility of ISs under hybrid cloud computing environments.

  7. Cross-coupling integral adaptive robust posture control of a pneumatic parallel platform

    Institute of Scientific and Technical Information of China (English)

    左赫; 陶国良

    2016-01-01

    A pneumatic parallel platform driven by an air cylinder and three circumambient pneumatic muscles was considered. Firstly, a mathematical model of the pneumatic servo system was developed for the MIMO nonlinear model-based controller designed. The pneumatic muscles were controlled by three proportional position valves, and the air cylinder was controlled by a proportional pressure valve. As the forward kinematics of this structure had no analytical solution, the control strategy should be designed in joint space. A cross-coupling integral adaptive robust controller (CCIARC) which combined cross-coupling control strategy and traditional adaptive robust control (ARC) theory was developed by back-stepping method to accomplish trajectory tracking control of the parallel platform. The cross-coupling part of the controller stabilized the length error in joint space as well as the synchronization error, and the adaptive robust control part attenuated the adverse effects of modelling error and disturbance. The force character of the pneumatic muscles was difficult to model precisely, so the on-line recursive least square estimation (RLSE) method was employed to modify the model compensation. The projector mapping method was used to condition the RLSE algorithm to bound the parameters estimated. An integral feedback part was added to the traditional robust function to reduce the negative influence of the slow time-varying characteristic of pneumatic muscles and enhance the ability of trajectory tracking. The stability of the controller designed was proved through Laypunov’s theory. Various contrast controllers were designed to testify the newly designed components of the CCIARC. Extensive experiments were conducted to illustrate the performance of the controller.

  8. Conceptual study proposal for the integration and management of biochemical markers of environmental contamination use

    Directory of Open Access Journals (Sweden)

    Vera Lúcia S. S. de Castro

    2012-03-01

    Full Text Available Sustainable agriculture prioritizes the rational use of land and biota. For this, there is a need for understanding the interaction between the agriculture inputs and the ecosystems. However, there is a lack of easy access methods for verifying environmental contamination due to many of these products, such as pesticides and their mixtures. The application of alternative methods for monitoring degraded areas can generate economic advantages when compared to the implementation of protocols for analysis using high cost methods which demand a longer analysis time. Since environmental health can be accessed through studies using biomarkers, the approach presented here aims to discuss some aspects on the environmental risk monitoring with sentinel non-target organisms, focusing on biochemical parameters. Such parameters showed that the pesticide penetrated into the body and caused a response according to the dose or time of exposition. These parameters shall be used as biochemical biomarkers in programs for environmental monitoring because of the early identification of changes. The results obtained through its use shall be used to support policies related to environmental risks management.

  9. Purdue Ionomics Information Management System. An Integrated Functional Genomics Platform1[C][W][OA

    Science.gov (United States)

    Baxter, Ivan; Ouzzani, Mourad; Orcun, Seza; Kennedy, Brad; Jandhyala, Shrinivas S.; Salt, David E.

    2007-01-01

    The advent of high-throughput phenotyping technologies has created a deluge of information that is difficult to deal with without the appropriate data management tools. These data management tools should integrate defined workflow controls for genomic-scale data acquisition and validation, data storage and retrieval, and data analysis, indexed around the genomic information of the organism of interest. To maximize the impact of these large datasets, it is critical that they are rapidly disseminated to the broader research community, allowing open access for data mining and discovery. We describe here a system that incorporates such functionalities developed around the Purdue University high-throughput ionomics phenotyping platform. The Purdue Ionomics Information Management System (PiiMS) provides integrated workflow control, data storage, and analysis to facilitate high-throughput data acquisition, along with integrated tools for data search, retrieval, and visualization for hypothesis development. PiiMS is deployed as a World Wide Web-enabled system, allowing for integration of distributed workflow processes and open access to raw data for analysis by numerous laboratories. PiiMS currently contains data on shoot concentrations of P, Ca, K, Mg, Cu, Fe, Zn, Mn, Co, Ni, B, Se, Mo, Na, As, and Cd in over 60,000 shoot tissue samples of Arabidopsis (Arabidopsis thaliana), including ethyl methanesulfonate, fast-neutron and defined T-DNA mutants, and natural accession and populations of recombinant inbred lines from over 800 separate experiments, representing over 1,000,000 fully quantitative elemental concentrations. PiiMS is accessible at www.purdue.edu/dp/ionomics. PMID:17189337

  10. Construction of a test platform for Test Blanket Module (TBM) systems integration and maintenance in ITER Port Cell #16

    Energy Technology Data Exchange (ETDEWEB)

    Vála, Ladislav, E-mail: ladislav.vala@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Reungoat, Mathieu, E-mail: mathieu.reungoat@cvrez.cz [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Vician, Martin [Centrum výzkumu Řež, Hlavní 130, 250 68 Husinec-Řež (Czech Republic); Poitevin, Yves; Ricapito, Italo; Zmitko, Milan; Panayotov, Dobromir [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain)

    2015-10-15

    Highlights: • A non-nuclear, full size facility – TBM platform – is under construction in CVR. • It is designed for tests, optimization and validation of TBS maintenance operations. • It will allow testing and validation of specific maintenance tools and RH equipment. • It reproduces ITER Port Cell #16, as well as the TBS interfaces and main equipment. • The TBM platform will be available for full operation in the first half of 2016. - Abstract: This paper describes a project of a non-nuclear, 1:1 scale testing platform dedicated to tests, optimization and validation of integration and maintenance operations for the European TBM systems in the ITER Port Cell #16. This TBM platform is currently under construction in Centrum výzkumu Řež, Czech Republic. The facility is realized within the scope of the SUSEN project and its full operation is foreseen in the first half of 2016.

  11. OTEC platform configuration and integration. Appendixes to Volume II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Price, David

    1978-07-07

    Detailed information and conceptual design drawings for the SPAR and SPHERE platforms for an OTEC commercial plant are presented. A work breakdown structure and a detailed estimate of the SPAR platform weight are included. (WHK)

  12. Microfluidic platforms employing integrated fluorescent or luminescent chemical sensors: a review of methods, scope and applications

    Science.gov (United States)

    Pfeiffer, Simon A.; Nagl, Stefan

    2015-09-01

    Herein we critically review microfluidic platforms that contain integrated fluorescent or luminescent chemical sensor assemblies. These were employed in particular for miniaturized oxygen and pH sensing. Microchips with optical temperature sensing capability are also covered since these share many concepts and applications. Other analytes and derived parameters from the above analytes are found in some sensing approaches in microfluidics. After an introduction, the work is structured into three main chapters dealing with the fabrication and microintegration of these sensors, readout and detection strategies, and applications of these microsystems. The fabrication is discussed with a focus on soft lithography-based approaches in polydimethylsiloxane (PDMS) or PDMS and glass hybrid devices that form the majority of work so far. Alternative approaches, particularly using glass or quartz as the main chip material are also covered. Detection techniques employed to date are the subject of the next chapter, where simple intensity as well as lifetime- or wavelength-referenced schemes are presented and the utility of image-based sensing on the microscale is discussed. Lastly, exciting applications of these microfluidic chips are highlighted. Luminescent oxygen and pH sensing has been of particular interest in the field of microbioreactors but other areas are also of interest, particularly chemical reactors and electrophoresis. Optical temperature sensing is discussed and its use in fundamental studies as well as in enzyme reactors. Integrated microsystems with biosensing capabilities and some for monitoring of metal ions and other analytes are also presented.

  13. A web platform for integrated surface water - groundwater modeling and data management

    Science.gov (United States)

    Fatkhutdinov, Aybulat; Stefan, Catalin; Junghanns, Ralf

    2016-04-01

    Model-based decision support systems are considered to be reliable and time-efficient tools for resources management in various hydrology related fields. However, searching and acquisition of the required data, preparation of the data sets for simulations as well as post-processing, visualization and publishing of the simulations results often requires significantly more work and time than performing the modeling itself. The purpose of the developed software is to combine data storage facilities, data processing instruments and modeling tools in a single platform which potentially can reduce time required for performing simulations, hence decision making. The system is developed within the INOWAS (Innovative Web Based Decision Support System for Water Sustainability under a Changing Climate) project. The platform integrates spatially distributed catchment scale rainfall - runoff, infiltration and groundwater flow models with data storage, processing and visualization tools. The concept is implemented in a form of a web-GIS application and is build based on free and open source components, including the PostgreSQL database management system, Python programming language for modeling purposes, Mapserver for visualization and publishing the data, Openlayers for building the user interface and others. Configuration of the system allows performing data input, storage, pre- and post-processing and visualization in a single not disturbed workflow. In addition, realization of the decision support system in the form of a web service provides an opportunity to easily retrieve and share data sets as well as results of simulations over the internet, which gives significant advantages for collaborative work on the projects and is able to significantly increase usability of the decision support system.

  14. A platform to integrate climate information and rural telemedicine in Malawi

    Science.gov (United States)

    Lowe, R.; Chadza, T.; Chirombo, J.; Fonda, C.; Muyepa, A.; Nkoloma, M.; Pietrosemoli, E.; Radicella, S. M.; Tompkins, A. M.; Zennaro, M.

    2012-04-01

    It is commonly accepted that climate plays a role in the transmission of many infectious diseases, particularly those transmitted by mosquitoes such as malaria, which is one of the most important causes of mortality and morbidity in developing countries. Due to time lags involved in the climate-disease transmission system, lagged observed climate variables could provide some predictive lead for forecasting disease epidemics. This lead time could be extended by using forecasts of the climate in disease prediction models. This project aims to implement a platform for the dissemination of climate-driven disease risk forecasts, using a telemedicine approach. A pilot project has been established in Malawi, where a 162 km wireless link has been installed, spanning from Blantyre City to remote health facilities in the district of Mangochi in the Southern region, bordering Lake Malawi. This long Wi-Fi technology allows rural health facilities to upload real-time disease cases as they occur to an online health information system (DHIS2); a national medical database repository administered by the Ministry of Health. This technology provides a real-time data logging system for disease incidence monitoring and facilitates the flow of information between local and national levels. This platform allows statistical and dynamical disease prediction models to be rapidly updated with real-time climate and epidemiological information. This permits health authorities to target timely interventions ahead of an imminent increase in malaria incidence. By integrating meteorological and health information systems in a statistical-dynamical prediction model, we show that a long-distance Wi-Fi link is a practical and inexpensive means to enable the rapid analysis of real-time information in order to target disease prevention and control measures and mobilise resources at the local level.

  15. Rice TOGO Browser: A platform to retrieve integrated information on rice functional and applied genomics.

    Science.gov (United States)

    Nagamura, Yoshiaki; Antonio, Baltazar A; Sato, Yutaka; Miyao, Akio; Namiki, Nobukazu; Yonemaru, Jun-ichi; Minami, Hiroshi; Kamatsuki, Kaori; Shimura, Kan; Shimizu, Yuji; Hirochika, Hirohiko

    2011-02-01

    The Rice TOGO Browser is an online public resource designed to facilitate integration and visualization of mapping data of bacterial artificial chromosome (BAC)/P1-derived artificial chromosome (PAC) clones, genes, restriction fragment length polymorphism (RFLP)/simple sequence repeat (SSR) markers and phenotype data represented as quantitative trait loci (QTLs) onto the genome sequence, and to provide a platform for more efficient utilization of genome information from the point of view of applied genomics as well as functional genomics. Three search options, namely keyword search, region search and trait search, generate various types of data in a user-friendly interface with three distinct viewers, a chromosome viewer, an integrated map viewer and a sequence viewer, thereby providing the opportunity to view the position of genes and/or QTLs at the chromosomal level and to retrieve any sequence information in a user-defined genome region. Furthermore, the gene list, marker list and genome sequence in a specified region delineated by RFLP/SSR markers and any sequences designed as primers can be viewed and downloaded to support forward genetics approaches. An additional feature of this database is the graphical viewer for BLAST search to reveal information not only for regions with significant sequence similarity but also for regions adjacent to those with similarity but with no hits between sequences. An easy to use and intuitive user interface can help a wide range of users in retrieving integrated mapping information including agronomically important traits on the rice genome sequence. The database can be accessed at http://agri-trait.dna.affrc.go.jp/.

  16. BiGG Models: A platform for integrating, standardizing and sharing genome-scale models.

    Science.gov (United States)

    King, Zachary A; Lu, Justin; Dräger, Andreas; Miller, Philip; Federowicz, Stephen; Lerman, Joshua A; Ebrahim, Ali; Palsson, Bernhard O; Lewis, Nathan E

    2016-01-01

    Genome-scale metabolic models are mathematically-structured knowledge bases that can be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can generate and test hypotheses when integrated with experimental data. To maximize the value of these models, centralized repositories of high-quality models must be established, models must adhere to established standards and model components must be linked to relevant databases. Tools for model visualization further enhance their utility. To meet these needs, we present BiGG Models (http://bigg.ucsd.edu), a completely redesigned Biochemical, Genetic and Genomic knowledge base. BiGG Models contains more than 75 high-quality, manually-curated genome-scale metabolic models. On the website, users can browse, search and visualize models. BiGG Models connects genome-scale models to genome annotations and external databases. Reaction and metabolite identifiers have been standardized across models to conform to community standards and enable rapid comparison across models. Furthermore, BiGG Models provides a comprehensive application programming interface for accessing BiGG Models with modeling and analysis tools. As a resource for highly curated, standardized and accessible models of metabolism, BiGG Models will facilitate diverse systems biology studies and support knowledge-based analysis of diverse experimental data.

  17. Miniaturized devices towards an integrated lab-on-a-chip platform for DNA diagnostics

    Science.gov (United States)

    Kaprou, G.; Papadakis, G.; Kokkoris, G.; Papadopoulos, V.; Kefala, I.; Papageorgiou, D.; Gizeli, E.; Tserepi, A.

    2015-06-01

    Microfluidics is an emerging technology enabling the development of Lab-on-a-chip (LOC) systems for clinical diagnostics, drug discovery and screening, food safety and environmental analysis. LOC systems integrate and scale down one or several laboratory functions on a single chip of a few mm2 to cm2 in size, and account for many advantages on biochemical analyses, such as low sample and reagent consumption, low cost, reduced analysis time, portability and point-of-need compatibility. Currently, available nucleic acid diagnostic tests take advantage of Polymerase Chain Reaction (PCR) that allows exponential amplification of portions of nucleic acid sequences that can be used as indicators for the identification of various diseases. Here, we present a comparison between static chamber and continuous flow miniaturized PCR devices, in terms of energy consumption for devices fabricated on the same material stack, with identical sample volume and channel dimensions. The comparison is implemented by a computational study coupling heat transfer in both solid and fluid, mass conservation of species, and joule heating. Based on the conclusions of this study, we develop low-cost and fast DNA amplification devices for both PCR and isothermal amplification, and we implement them in the detection of mutations related to breast cancer. The devices are fabricated by mass production amenable technologies on printed circuit board (PCB) substrates, where copper facilitates the incorporation of on-chip microheaters, defining the thermal zones necessary for PCR or isothermal amplification methods.

  18. Experimental Peptide Identification Repository (EPIR): an integrated peptide-centric platform for validation and mining of tandem mass spectrometry data

    DEFF Research Database (Denmark)

    Kristensen, Dan Bach; Brønd, Jan Christian; Nielsen, Peter Aagaard;

    2004-01-01

    is an integrated software platform for storage, validation, and mining of LC MS/MS-derived peptide evidence. EPIR is a cumulative data repository where precursor ions are linked to peptide assignments and protein associations returned by a search engine (e.g. Mascot, Sequest, or PepSea). Any number of datasets can...

  19. Effects of polyhalogenated hydrocarbons and related contaminants on common tern reproduction: Integration of (bio)chemical and ecological responses

    Energy Technology Data Exchange (ETDEWEB)

    Murk, A.J. [Agricultural Univ., Wageningen (Netherlands); Boudewijn, T.J.; Dirksen, S. [Bureau Waardenburg, Culemborg (Netherlands); Bosveld, A.T.C. [Univ. of Utrecht (Netherlands); Rossaert, G.; Ysebaert, T.; Meire, P. [Inst. for Nature Management, Hasselt (Belgium); Meininger, P.L.

    1995-12-31

    An integrated ecotoxicological study was made to establish the possible effects of polyhalogenated hydrocarbons (PHAHs) on common tern (Stema hirundo) reproduction. In eight Dutch or Belgian colonies, breeding biology and food choice were determined. In all colonies 15 second eggs from three-egg clutches were collected for artificial incubation and (bio)chemical analysis. Results from these analyses were combined with biological data from the remaining eggs of the clutches. A relationship was found between yolksac mono-ortho PCB levels and main food species (fish or insects) of the adult terns before egg-laying. Colony average breeding data differed only slightly, and were difficult to relate to PHAH levels. When the colonies were grouped after yolksac PHAH-patterns and main food species, significant differences in average egg laying date, egg laying period, incubation period, egg volume and chick weight could be related to differences in yolksac PHAH and retinoid levels, and hepatic EROD activity. The data from all colonies also were used as one dataset and correlated with the (bio)chemical parameters. In summary there were significant correlations or clear trends between yolksac PHAHs or hepatic EROD-activity and prolonged egg laying and incubation period, and smaller eggs and chicks. Lower yolksac retinoid and plasma thyroid hormone levels, and a higher ratio of plasma retinol over yolksac retinoids correlated with longer egg laying and incubation periods, and smaller chicks and eggs (only with thyroid hormone).

  20. LabKey Server: An open source platform for scientific data integration, analysis and collaboration

    Directory of Open Access Journals (Sweden)

    Lum Karl

    2011-03-01

    Full Text Available Abstract Background Broad-based collaborations are becoming increasingly common among disease researchers. For example, the Global HIV Enterprise has united cross-disciplinary consortia to speed progress towards HIV vaccines through coordinated research across the boundaries of institutions, continents and specialties. New, end-to-end software tools for data and specimen management are necessary to achieve the ambitious goals of such alliances. These tools must enable researchers to organize and integrate heterogeneous data early in the discovery process, standardize processes, gain new insights into pooled data and collaborate securely. Results To meet these needs, we enhanced the LabKey Server platform, formerly known as CPAS. This freely available, open source software is maintained by professional engineers who use commercially proven practices for software development and maintenance. Recent enhancements support: (i Submitting specimens requests across collaborating organizations (ii Graphically defining new experimental data types, metadata and wizards for data collection (iii Transitioning experimental results from a multiplicity of spreadsheets to custom tables in a shared database (iv Securely organizing, integrating, analyzing, visualizing and sharing diverse data types, from clinical records to specimens to complex assays (v Interacting dynamically with external data sources (vi Tracking study participants and cohorts over time (vii Developing custom interfaces using client libraries (viii Authoring custom visualizations in a built-in R scripting environment. Diverse research organizations have adopted and adapted LabKey Server, including consortia within the Global HIV Enterprise. Atlas is an installation of LabKey Server that has been tailored to serve these consortia. It is in production use and demonstrates the core capabilities of LabKey Server. Atlas now has over 2,800 active user accounts originating from approximately 36

  1. Cantilever-based bio-chemical sensor integrated in a microliquid handling system

    DEFF Research Database (Denmark)

    Thaysen, Jacob; Marie, Rodolphe; Boisen, Anja

    2001-01-01

    The cantilevers have integrated piezoresistive readout which, compared to optical readout, enables simple measurements on even non-transparent liquids, such as blood. First, we introduce a simple theory for using piezoresistive cantilevers as surface stress sensors. Then, the sensor fabrication b...

  2. Supervised Regularized Canonical Correlation Analysis: integrating histologic and proteomic measurements for predicting biochemical recurrence following prostate surgery

    Directory of Open Access Journals (Sweden)

    Golugula Abhishek

    2011-12-01

    Full Text Available Abstract Background Multimodal data, especially imaging and non-imaging data, is being routinely acquired in the context of disease diagnostics; however, computational challenges have limited the ability to quantitatively integrate imaging and non-imaging data channels with different dimensionalities and scales. To the best of our knowledge relatively few attempts have been made to quantitatively fuse such data to construct classifiers and none have attempted to quantitatively combine histology (imaging and proteomic (non-imaging measurements for making diagnostic and prognostic predictions. The objective of this work is to create a common subspace to simultaneously accommodate both the imaging and non-imaging data (and hence data corresponding to different scales and dimensionalities, called a metaspace. This metaspace can be used to build a meta-classifier that produces better classification results than a classifier that is based on a single modality alone. Canonical Correlation Analysis (CCA and Regularized CCA (RCCA are statistical techniques that extract correlations between two modes of data to construct a homogeneous, uniform representation of heterogeneous data channels. In this paper, we present a novel modification to CCA and RCCA, Supervised Regularized Canonical Correlation Analysis (SRCCA, that (1 enables the quantitative integration of data from multiple modalities using a feature selection scheme, (2 is regularized, and (3 is computationally cheap. We leverage this SRCCA framework towards the fusion of proteomic and histologic image signatures for identifying prostate cancer patients at the risk of 5 year biochemical recurrence following radical prostatectomy. Results A cohort of 19 grade, stage matched prostate cancer patients, all of whom had radical prostatectomy, including 10 of whom had biochemical recurrence within 5 years of surgery and 9 of whom did not, were considered in this study. The aim was to construct a lower

  3. Biorefinery - development of chemical platforms through biomass integrated technologies; Biorefinaria - desenvolvimento de plataformas quimicas atraves de tecnologias integradas de biomassa

    Energy Technology Data Exchange (ETDEWEB)

    Sain, Mohini M.; Pervaiz, Muhammad; Correa, Carlos A.

    2009-07-01

    The sustainable industrial conversion of biomass into products with high aggregate dd value are still needing a partial restructure or even the complete of all economy basing on new research and development methods. A new approach consists of development of technologies for bio refineries and systems which are similar to the petroleum refinery, and involve processes of integrated conversion of biomass and equipment for fuel, energy and bio based biochemical products.

  4. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yafei [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Brott, David [Patient Safety, AstraZeneca R and D Wilmington, DE 19850 (United States); Luo, Wenli [Discovery Statistics, AstraZeneca R and D Waltham, MA 02451 (United States); Gangl, Eric [DMPK, AstraZeneca R and D Waltham, MA 02451 (United States); Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Valentin, Jean-Pierre [Global Safety Assessment, AstraZeneca R and D Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Bialecki, Russell, E-mail: russell.bialecki@astrazeneca.com [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States)

    2013-05-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development.

  5. A MEMS-Based Flow Rate and Flow Direction Sensing Platform with Integrated Temperature Compensation Scheme

    Directory of Open Access Journals (Sweden)

    Chia-Yen Lee

    2009-07-01

    Full Text Available This study develops a MEMS-based low-cost sensing platform for sensing gas flow rate and flow direction comprising four silicon nitride cantilever beams arranged in a cross-form configuration, a circular hot-wire flow meter suspended on a silicon nitride membrane, and an integrated resistive temperature detector (RTD. In the proposed device, the flow rate is inversely derived from the change in the resistance signal of the flow meter when exposed to the sensed air stream. To compensate for the effects of the ambient temperature on the accuracy of the flow rate measurements, the output signal from the flow meter is compensated using the resistance signal generated by the RTD. As air travels over the surface of the cross-form cantilever structure, the upstream cantilevers are deflected in the downward direction, while the downstream cantilevers are deflected in the upward direction. The deflection of the cantilever beams causes a corresponding change in the resistive signals of the piezoresistors patterned on their upper surfaces. The amount by which each beam deflects depends on both the flow rate and the orientation of the beam relative to the direction of the gas flow. Thus, following an appropriate compensation by the temperature-corrected flow rate, the gas flow direction can be determined through a suitable manipulation of the output signals of the four piezoresistors. The experimental results have confirmed that the resulting variation in the output signals of the integrated sensors can be used to determine not only the ambient temperature and the velocity of the air flow, but also its direction relative to the sensor with an accuracy of ± 7.5o error.

  6. A MEMS-Based Flow Rate and Flow Direction Sensing Platform with Integrated Temperature Compensation Scheme.

    Science.gov (United States)

    Ma, Rong-Hua; Wang, Dung-An; Hsueh, Tzu-Han; Lee, Chia-Yen

    2009-01-01

    This study develops a MEMS-based low-cost sensing platform for sensing gas flow rate and flow direction comprising four silicon nitride cantilever beams arranged in a cross-form configuration, a circular hot-wire flow meter suspended on a silicon nitride membrane, and an integrated resistive temperature detector (RTD). In the proposed device, the flow rate is inversely derived from the change in the resistance signal of the flow meter when exposed to the sensed air stream. To compensate for the effects of the ambient temperature on the accuracy of the flow rate measurements, the output signal from the flow meter is compensated using the resistance signal generated by the RTD. As air travels over the surface of the cross-form cantilever structure, the upstream cantilevers are deflected in the downward direction, while the downstream cantilevers are deflected in the upward direction. The deflection of the cantilever beams causes a corresponding change in the resistive signals of the piezoresistors patterned on their upper surfaces. The amount by which each beam deflects depends on both the flow rate and the orientation of the beam relative to the direction of the gas flow. Thus, following an appropriate compensation by the temperature-corrected flow rate, the gas flow direction can be determined through a suitable manipulation of the output signals of the four piezoresistors. The experimental results have confirmed that the resulting variation in the output signals of the integrated sensors can be used to determine not only the ambient temperature and the velocity of the air flow, but also its direction relative to the sensor with an accuracy of ± 7.5° error.

  7. IMPACT_S: integrated multiprogram platform to analyze and combine tests of selection.

    Science.gov (United States)

    Maldonado, Emanuel; Sunagar, Kartik; Almeida, Daniela; Vasconcelos, Vitor; Antunes, Agostinho

    2014-01-01

    Among the major goals of research in evolutionary biology are the identification of genes targeted by natural selection and understanding how various regimes of evolution affect the fitness of an organism. In particular, adaptive evolution enables organisms to adapt to changing ecological factors such as diet, temperature, habitat, predatory pressures and prey abundance. An integrative approach is crucial for the identification of non-synonymous mutations that introduce radical changes in protein biochemistry and thus in turn influence the structure and function of proteins. Performing such analyses manually is often a time-consuming process, due to the large number of statistical files generated from multiple approaches, especially when assessing numerous taxa and/or large datasets. We present IMPACT_S, an easy-to-use Graphical User Interface (GUI) software, which rapidly and effectively integrates, filters and combines results from three widely used programs for assessing the influence of selection: Codeml (PAML package), Datamonkey and TreeSAAP. It enables the identification and tabulation of sites detected by these programs as evolving under the influence of positive, neutral and/or negative selection in protein-coding genes. IMPACT_S further facilitates the automatic mapping of these sites onto the three-dimensional structures of proteins. Other useful tools incorporated in IMPACT_S include Jmol, Archaeopteryx, Gnuplot, PhyML, a built-in Swiss-Model interface and a PDB downloader. The relevance and functionality of IMPACT_S is shown through a case study on the toxicoferan-reptilian Cysteine-rich Secretory Proteins (CRiSPs). IMPACT_S is a platform-independent software released under GPLv3 license, freely available online from http://impact-s.sourceforge.net.

  8. IMPACT_S: integrated multiprogram platform to analyze and combine tests of selection.

    Directory of Open Access Journals (Sweden)

    Emanuel Maldonado

    Full Text Available Among the major goals of research in evolutionary biology are the identification of genes targeted by natural selection and understanding how various regimes of evolution affect the fitness of an organism. In particular, adaptive evolution enables organisms to adapt to changing ecological factors such as diet, temperature, habitat, predatory pressures and prey abundance. An integrative approach is crucial for the identification of non-synonymous mutations that introduce radical changes in protein biochemistry and thus in turn influence the structure and function of proteins. Performing such analyses manually is often a time-consuming process, due to the large number of statistical files generated from multiple approaches, especially when assessing numerous taxa and/or large datasets. We present IMPACT_S, an easy-to-use Graphical User Interface (GUI software, which rapidly and effectively integrates, filters and combines results from three widely used programs for assessing the influence of selection: Codeml (PAML package, Datamonkey and TreeSAAP. It enables the identification and tabulation of sites detected by these programs as evolving under the influence of positive, neutral and/or negative selection in protein-coding genes. IMPACT_S further facilitates the automatic mapping of these sites onto the three-dimensional structures of proteins. Other useful tools incorporated in IMPACT_S include Jmol, Archaeopteryx, Gnuplot, PhyML, a built-in Swiss-Model interface and a PDB downloader. The relevance and functionality of IMPACT_S is shown through a case study on the toxicoferan-reptilian Cysteine-rich Secretory Proteins (CRiSPs. IMPACT_S is a platform-independent software released under GPLv3 license, freely available online from http://impact-s.sourceforge.net.

  9. Integrating the New Generation of Isolde Controls into a Multi-Platform Environment

    CERN Document Server

    Deloose, I

    1996-01-01

    The CERN ISOLDE isotope separator facility has been relocated on the PS Booster machine and commissioned in spring 1992. Since then, the Isolde equipment is controlled by Front End Computers running DOS and desktop PCs, also named consoles, running Windows 3.1 as graphical user interface. Because of the success of the powerful development tools used at Isolde on the Windows platform (Visual Basic, Excel...), the desktop architecture has been extended to access the UNIX based PS control system through an access controlled ³gateway² computer. Linked to the introduction of Windows 95 at CERN, the Console - Equipment (FEC) computer communication model has been redesigned with enhanced performances and new features. The gradual replacement of IPX/SPX by TCP/IP as client-server communication protocol created new perspectives, like equipment access from the World Wide Web or through a wireless telephone connection. This report will explain the evolution from the initial ISOLDE control system up to its integration ...

  10. Systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.

    Science.gov (United States)

    Chen, Bor-Sen; Wu, Chia-Chou

    2013-10-11

    Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived from insight into: (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This review describes current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers. We also discuss challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.

  11. Global transcript structure resolution of high gene density genomes through multi-platform data integration.

    Science.gov (United States)

    O'Grady, Tina; Wang, Xia; Höner Zu Bentrup, Kerstin; Baddoo, Melody; Concha, Monica; Flemington, Erik K

    2016-10-14

    Annotation of herpesvirus genomes has traditionally been undertaken through the detection of open reading frames and other genomic motifs, supplemented with sequencing of individual cDNAs. Second generation sequencing and high-density microarray studies have revealed vastly greater herpesvirus transcriptome complexity than is captured by existing annotation. The pervasive nature of overlapping transcription throughout herpesvirus genomes, however, poses substantial problems in resolving transcript structures using these methods alone. We present an approach that combines the unique attributes of Pacific Biosciences Iso-Seq long-read, Illumina short-read and deepCAGE (Cap Analysis of Gene Expression) sequencing to globally resolve polyadenylated isoform structures in replicating Epstein-Barr virus (EBV). Our method, Transcriptome Resolution through Integration of Multi-platform Data (TRIMD), identifies nearly 300 novel EBV transcripts, quadrupling the size of the annotated viral transcriptome. These findings illustrate an array of mechanisms through which EBV achieves functional diversity in its relatively small, compact genome including programmed alternative splicing (e.g. across the IR1 repeats), alternative promoter usage by LMP2 and other latency-associated transcripts, intergenic splicing at the BZLF2 locus, and antisense transcription and pervasive readthrough transcription throughout the genome.

  12. Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

    Directory of Open Access Journals (Sweden)

    Bor-Sen Chen

    2013-10-01

    Full Text Available Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived from insight into: (i system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This review describes current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers. We also discuss challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.

  13. Integrated cell-based platform to study EGFR activation and transactivation.

    Science.gov (United States)

    Caruso, Marie-Elaine; Clément, Paule; Parent, Stéphane; Dupriez, Vincent; Bossé, Roger; Rouleau, Nathalie

    2013-09-01

    The epidermal growth factor receptor (EGFR) pathway is one of the most deregulated molecular pathways in human epithelial cancers. Many approved drugs were optimized to directly target EGFR but yielded only modest clinical improvement in cancer patients due to low efficacy and drug resistance. Transactivation of EGFR by other cell surface receptors such as G-protein-coupled receptors (GPCRs) was proposed to explain this lack of efficacy. Even if direct EGFR activation and transactivation by GPCR contribute to the activation of the same signaling pathways, they are often studied as independent events resulting in partial investigation of a drug's mechanism of action. We present a novel high-throughput approach that integrates interrogation of direct activation of EGFR and its transactivation via GPCR activation. Using distinct technology platforms, three readouts were used to measure (1) direct activation of GPCR via cyclic adenosine monophosphate (cAMP) detection, (2) direct activation of EGFR through the release of intracellular Ca(2+), and (3) EGFR transactivation by GPCR using the detection of p-extracellular-signal-regulated kinases 1/2 (p-ERK1/2). In addition to being simple, quick, and homogenous, our methods were shown to be more sensitive than those in current use. These enabling tools should improve the knowledge pertaining to GPCRs and receptor tyrosine kinases trans-regulation and facilitate the design of more potent and better targeted new therapeutic strategies.

  14. Functional analysis of OMICs data and small molecule compounds in an integrated "knowledge-based" platform.

    Science.gov (United States)

    Nikolsky, Yuri; Kirillov, Eugene; Zuev, Roman; Rakhmatulin, Eugene; Nikolskaya, Tatiana

    2009-01-01

    Analysis of microarray, SNPs, proteomics, and other high-throughput (OMICs) data is challenging because of its biological complexity and high level of technical and biological noise. One way to deal with both problems is to perform analysis with a high-fidelity annotated knowledge base of protein interactions, pathways, and functional ontologies. This knowledge base has to be structured in a computer-readable format and must include software tools for managing experimental data, analysis, and reporting. Here we present MetaDiscovery, an integrated platform for functional data analysis which is being developed at GeneGo for the past 8 years. On the content side, MetaDiscovery encompasses a comprehensive database of protein interactions of different types, pathways, network models and 10 functional ontologies covering human, mouse, and rat proteins. The analytical toolkit includes tools for gene/protein list enrichment analysis, statistical "interactome" tool for identification of over- and under-connected proteins in the data set, and a network module made up of network generation algorithms and filters. The suite also features MetaSearch, an application for combinatorial search of the database content, as well as a Java-based tool called MapEditor for drawing and editing custom pathway maps. Applications of MetaDiscovery include identification of potential biomarkers and drug targets, pathway hypothesis generation, analysis of biological effects for novel small molecule compounds, and clinical applications (analysis of large cohorts of patients and translational and personalized medicine).

  15. An integrated telemedicine platform for the assessment of affective physiological states.

    Science.gov (United States)

    Katsis, Christos D; Ganiatsas, George; Fotiadis, Dimitrios I

    2006-08-01

    AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a) a multisensorial wearable, (b) a data acquisition and wireless communication module, (c) a feature extraction module, (d) a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e) an intelligent emotion recognition module, and (f) the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face) is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car racing drivers.

  16. An integrated telemedicine platform for the assessment of affective physiological states

    Directory of Open Access Journals (Sweden)

    Ganiatsas George

    2006-08-01

    Full Text Available Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a a multisensorial wearable, (b a data acquisition and wireless communication module, (c a feature extraction module, (d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e an intelligent emotion recognition module, and (f the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car. racing drivers.

  17. A Semantic Big Data Platform for Integrating Heterogeneous Wearable Data in Healthcare.

    Science.gov (United States)

    Mezghani, Emna; Exposito, Ernesto; Drira, Khalil; Da Silveira, Marcos; Pruski, Cédric

    2015-12-01

    Advances supported by emerging wearable technologies in healthcare promise patients a provision of high quality of care. Wearable computing systems represent one of the most thrust areas used to transform traditional healthcare systems into active systems able to continuously monitor and control the patients' health in order to manage their care at an early stage. However, their proliferation creates challenges related to data management and integration. The diversity and variety of wearable data related to healthcare, their huge volume and their distribution make data processing and analytics more difficult. In this paper, we propose a generic semantic big data architecture based on the "Knowledge as a Service" approach to cope with heterogeneity and scalability challenges. Our main contribution focuses on enriching the NIST Big Data model with semantics in order to smartly understand the collected data, and generate more accurate and valuable information by correlating scattered medical data stemming from multiple wearable devices or/and from other distributed data sources. We have implemented and evaluated a Wearable KaaS platform to smartly manage heterogeneous data coming from wearable devices in order to assist the physicians in supervising the patient health evolution and keep the patient up-to-date about his/her status.

  18. Material gain engineering in GeSn/Ge quantum wells integrated with an Si platform

    Science.gov (United States)

    Mączko, H. S.; Kudrawiec, R.; Gladysiewicz, M.

    2016-09-01

    It is shown that compressively strained Ge1‑xSnx/Ge quantum wells (QWs) grown on a Ge substrate with 0.1 ≤ x ≤ 0.2 and width of 8 nm ≤ d ≤ 14 nm are a very promising gain medium for lasers integrated with an Si platform. Such QWs are type-I QWs with a direct bandgap and positive transverse electric mode of material gain, i.e. the modal gain. The electronic band structure near the center of Brillouin zone has been calculated for various Ge1‑xSnx/Ge QWs with use of the 8-band kp Hamiltonian. To calculate the material gain for these QWs, occupation of the L valley in Ge barriers has been taken into account. It is clearly shown that this occupation has a lot of influence on the material gain in the QWs with low Sn concentrations (Sn  15%). However, for QWs with Sn > 20% the critical thickness of a GeSn layer deposited on a Ge substrate starts to play an important role. Reduction in the QW width shifts up the ground electron subband in the QW and increases occupation of the L valley in the barriers instead of the Γ valley in the QW region.

  19. An Integrated Approach to Fatigue Life Prediction of Whole System for Offshore Platforms

    Institute of Scientific and Technical Information of China (English)

    方华灿; 段梦兰; 许发彦; 吴永宁; 樊晓东

    2001-01-01

    The failure of one or even more components usually does not lead to the collapse of the whole structure. Most of theanalysis of fatigue is centered on only a single component which the researchers are interested in or much attentionshould be paid to. However, the collapse of a structure is the result of failure of a series of components in a specific orderor path. This paper proposes an integrated approach to fatigue life prediction of whole structural system for offshoreplatforms, mainly describing the basic principles and prediction method. A method is presented for determining the fail-ure path of the whole structure system and calculating the fatigue life in the determined failure path. The correspondingfinal collapse criteria for the whole structure system are discussed. A simple method of equivalent fatigue stress range cal-culation and a mathematical model of structural component fatigue life estimation in consideration of sea wave and seaice loads are provided. As an application of the proposed approach, a fixed production platform Bohai No. 8 is chosenfor the predication of fatigue life of the whole structure system by means of the software OSFAC developed based on thepresent methods.

  20. Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform

    Science.gov (United States)

    Li, Po-E; Lo, Chien-Chi; Anderson, Joseph J.; Davenport, Karen W.; Bishop-Lilly, Kimberly A.; Xu, Yan; Ahmed, Sanaa; Feng, Shihai; Mokashi, Vishwesh P.; Chain, Patrick S.G.

    2017-01-01

    Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows. These workflows, coupled with the ease of use of the environment, provide even novice next-generation sequencing users with the ability to perform many complex analyses with only a few mouse clicks and, within the context of the same environment, to visualize and further interrogate their results. This bioinformatics platform is an initial attempt at Empowering the Development of Genomics Expertise (EDGE) in a wide range of applications for microbial research. PMID:27899609

  1. Integration of HIV in child survival platforms: a novel programmatic pathway towards the 90–90–90 targets

    Directory of Open Access Journals (Sweden)

    Dick D Chamla

    2015-12-01

    Full Text Available Introduction: Integration of HIV into child survival platforms is an evolving territory with multiple connotations. Most literature on integration of HIV into other health services focuses on adults; however promising practices for children are emerging. These include the Double Dividend (DD framework, a new programming approach with dual goal of improving paediatric HIV care and child survival. In this commentary, the authors discuss why integrating HIV testing, treatment and care into child survival platforms is important, as well as its potential to advance progress towards global targets that call for, by 2020, 90% of children living with HIV to know their status, 90% of those diagnosed to be on treatment and 90% of those on treatment to be virally suppressed (90–90–90. Discussion: Integration is critical in improving health outcomes and efficiency gains. In children, integration of HIV in programmes such as immunization and nutrition has been associated with an increased uptake of HIV infant testing. Integration is increasingly recognized as a case-finding strategy for children missed from prevention of mother-to-child transmission programmes and as a platform for diffusing emerging technologies such as point-of-care diagnostics. These support progress towards the 90–90–90 targets by providing a pathway for early identification of HIV-infected children with co-morbidities, prompt initiation of treatment and improved survival. There are various promising practices that have demonstrated HIV outcomes; however, few have documented the benefits of integration on child survival interventions. The DD framework is well positioned to address the bidirectional impacts for both programmes. Conclusions: Integration provides an important programmatic pathway for accelerated progress towards the 90–90–90 targets. Despite this encouraging information, there are still challenges to be addressed in order to maximize the benefits of integration.

  2. Review of computer simulations of isotope effects on biochemical reactions: From the Bigeleisen equation to Feynman's path integral.

    Science.gov (United States)

    Wong, Kin-Yiu; Xu, Yuqing; Xu, Liang

    2015-11-01

    Enzymatic reactions are integral components in many biological functions and malfunctions. The iconic structure of each reaction path for elucidating the reaction mechanism in details is the molecular structure of the rate-limiting transition state (RLTS). But RLTS is very hard to get caught or to get visualized by experimentalists. In spite of the lack of explicit molecular structure of the RLTS in experiment, we still can trace out the RLTS unique "fingerprints" by measuring the isotope effects on the reaction rate. This set of "fingerprints" is considered as a most direct probe of RLTS. By contrast, for computer simulations, oftentimes molecular structures of a number of TS can be precisely visualized on computer screen, however, theoreticians are not sure which TS is the actual rate-limiting one. As a result, this is an excellent stage setting for a perfect "marriage" between experiment and theory for determining the structure of RLTS, along with the reaction mechanism, i.e., experimentalists are responsible for "fingerprinting", whereas theoreticians are responsible for providing candidates that match the "fingerprints". In this Review, the origin of isotope effects on a chemical reaction is discussed from the perspectives of classical and quantum worlds, respectively (e.g., the origins of the inverse kinetic isotope effects and all the equilibrium isotope effects are purely from quantum). The conventional Bigeleisen equation for isotope effect calculations, as well as its refined version in the framework of Feynman's path integral and Kleinert's variational perturbation (KP) theory for systematically incorporating anharmonicity and (non-parabolic) quantum tunneling, are also presented. In addition, the outstanding interplay between theory and experiment for successfully deducing the RLTS structures and the reaction mechanisms is demonstrated by applications on biochemical reactions, namely models of bacterial squalene-to-hopene polycyclization and RNA 2'-O

  3. The tsunami service bus, an integration platform for heterogeneous sensor systems

    Science.gov (United States)

    Haener, R.; Waechter, J.; Kriegel, U.; Fleischer, J.; Mueller, S.

    2009-04-01

    components remain unchanged, components can be maintained and evolved independently on each other and service functionality as a whole can be reused. In GITEWS the functional integration pattern was adopted by applying the principles of an Enterprise Service Bus (ESB) as a backbone. Four services provided by the so called Tsunami Service Bus (TSB) which are essential for early warning systems are realized compliant to services specified within the Sensor Web Enablement (SWE) initiative of the Open Geospatial Consortium (OGC). 3. ARCHITECTURE The integration platform was developed to access proprietary, heterogeneous sensor data and to provide them in a uniform manner for further use. Its core, the TSB provides both a messaging-backbone and -interfaces on the basis of a Java Messaging Service (JMS). The logical architecture of GITEWS consists of four independent layers: • A resource layer where physical or virtual sensors as well as data or model storages provide relevant measurement-, event- and analysis-data: Utilizable for the TSB are any kind of data. In addition to sensors databases, model data and processing applications are adopted. SWE specifies encoding both to access and to describe these data in a comprehensive way: 1. Sensor Model Language (SensorML): Standardized description of sensors and sensor data 2. Observations and Measurements (O&M): Model and encoding of sensor measurements • A service layer to collect and conduct data from heterogeneous and proprietary resources and provide them via standardized interfaces: The TSB enables interaction with sensors via the following services: 1. Sensor Observation Service (SOS): Standardized access to sensor data 2. Sensor Planning Service (SPS): Controlling of sensors and sensor networks 3. Sensor Alert Service (SAS): Active sending of data if defined events occur 4. Web Notification Service (WNS): Conduction of asynchronous dialogues between services • An orchestration layer where atomic services are composed and

  4. The VIPER project (Visualization Integration Platform for Exploration Research): a biologically inspired autonomous reconfigurable robotic platform for diverse unstructured environments

    Science.gov (United States)

    Schubert, Oliver J.; Tolle, Charles R.

    2004-09-01

    Over the last decade the world has seen numerous autonomous vehicle programs. Wheels and track designs are the basis for many of these vehicles. This is primarily due to four main reasons: a vast preexisting knowledge base for these designs, energy efficiency of power sources, scalability of actuators, and the lack of control systems technologies for handling alternate highly complex distributed systems. Though large efforts seek to improve the mobility of these vehicles, many limitations still exist for these systems within unstructured environments, e.g. limited mobility within industrial and nuclear accident sites where existing plant configurations have been extensively changed. These unstructured operational environments include missions for exploration, reconnaissance, and emergency recovery of objects within reconfigured or collapsed structures, e.g. bombed buildings. More importantly, these environments present a clear and present danger for direct human interactions during the initial phases of recovery operations. Clearly, the current classes of autonomous vehicles are incapable of performing in these environments. Thus the next generation of designs must include highly reconfigurable and flexible autonomous robotic platforms. This new breed of autonomous vehicles will be both highly flexible and environmentally adaptable. Presented in this paper is one of the most successful designs from nature, the snake-eel-worm (SEW). This design implements shape memory alloy (SMA) actuators which allow for scaling of the robotic SEW designs from sub-micron scale to heavy industrial implementations without major conceptual redesigns as required in traditional hydraulic, pneumatic, or motor driven systems. Autonomous vehicles based on the SEW design posses the ability to easily move between air based environments and fluid based environments with limited or no reconfiguration. Under a SEW designed vehicle, one not only achieves vastly improved maneuverability within a

  5. A big data geospatial analytics platform - Physical Analytics Integrated Repository and Services (PAIRS)

    Science.gov (United States)

    Hamann, H.; Jimenez Marianno, F.; Klein, L.; Albrecht, C.; Freitag, M.; Hinds, N.; Lu, S.

    2015-12-01

    A big data geospatial analytics platform:Physical Analytics Information Repository and Services (PAIRS)Fernando Marianno, Levente Klein, Siyuan Lu, Conrad Albrecht, Marcus Freitag, Nigel Hinds, Hendrik HamannIBM TJ Watson Research Center, Yorktown Heights, NY 10598A major challenge in leveraging big geospatial data sets is the ability to quickly integrate multiple data sources into physical and statistical models and be run these models in real time. A geospatial data platform called Physical Analytics Information and Services (PAIRS) is developed on top of open source hardware and software stack to manage Terabyte of data. A new data interpolation and re gridding is implemented where any geospatial data layers can be associated with a set of global grid where the grid resolutions is doubling for consecutive layers. Each pixel on the PAIRS grid have an index that is a combination of locations and time stamp. The indexing allow quick access to data sets that are part of a global data layers and allowing to retrieve only the data of interest. PAIRS takes advantages of parallel processing framework (Hadoop) in a cloud environment to digest, curate, and analyze the data sets while being very robust and stable. The data is stored on a distributed no-SQL database (Hbase) across multiple server, data upload and retrieval is parallelized where the original analytics task is broken up is smaller areas/volume, analyzed independently, and then reassembled for the original geographical area. The differentiating aspect of PAIRS is the ability to accelerate model development across large geographical regions and spatial resolution ranging from 0.1 m up to hundreds of kilometer. System performance is benchmarked on real time automated data ingestion and retrieval of Modis and Landsat data layers. The data layers are curated for sensor error, verified for correctness, and analyzed statistically to detect local anomalies. Multi-layer query enable PAIRS to filter different data

  6. An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks

    Directory of Open Access Journals (Sweden)

    Michael Gormley

    2011-01-01

    Full Text Available Identification of regulatory molecules in signaling pathways is critical for understanding cellular behavior. Given the complexity of the transcriptional gene network, the relationship between molecular expression and phenotype is difficult to determine using reductionist experimental methods. Computational models provide the means to characterize regulatory mechanisms and predict phenotype in the context of gene networks. Integrating gene expression data with phenotypic data in transcriptional network models enables systematic identification of critical molecules in a biological network. We developed an approach based on fuzzy logic to model cell budding in Saccharomyces cerevisiae using time series expression microarray data of the cell cycle. Cell budding is a phenotype of viable cells undergoing division. Predicted interactions between gene expression and phenotype reflected known biological relationships. Dynamic simulation analysis reproduced the behavior of the yeast cell cycle and accurately identified genes and interactions which are essential for cell viability.

  7. Integration of the virtual model of a Stewart platform with the avatar of a vehicle in a virtual reality

    Science.gov (United States)

    Herbuś, K.; Ociepka, P.

    2016-08-01

    The development of methods of computer aided design and engineering allows conducting virtual tests, among others concerning motion simulation of technical means. The paper presents a method of integrating an object in the form of a virtual model of a Stewart platform with an avatar of a vehicle moving in a virtual environment. The area of the problem includes issues related to the problem of fidelity of mapping the work of the analyzed technical mean. The main object of investigations is a 3D model of a Stewart platform, which is a subsystem of the simulator designated for driving learning for disabled persons. The analyzed model of the platform, prepared for motion simulation, was created in the “Motion Simulation” module of a CAD/CAE class system Siemens PLM NX. Whereas the virtual environment, in which the moves the avatar of the passenger car, was elaborated in a VR class system EON Studio. The element integrating both of the mentioned software environments is a developed application that reads information from the virtual reality (VR) concerning the current position of the car avatar. Then, basing on the accepted algorithm, it sends control signals to respective joints of the model of the Stewart platform (CAD).

  8. Integrated Analysis Platform: An Open-Source Information System for High-Throughput Plant Phenotyping.

    Science.gov (United States)

    Klukas, Christian; Chen, Dijun; Pape, Jean-Michel

    2014-06-01

    High-throughput phenotyping is emerging as an important technology to dissect phenotypic components in plants. Efficient image processing and feature extraction are prerequisites to quantify plant growth and performance based on phenotypic traits. Issues include data management, image analysis, and result visualization of large-scale phenotypic data sets. Here, we present Integrated Analysis Platform (IAP), an open-source framework for high-throughput plant phenotyping. IAP provides user-friendly interfaces, and its core functions are highly adaptable. Our system supports image data transfer from different acquisition environments and large-scale image analysis for different plant species based on real-time imaging data obtained from different spectra. Due to the huge amount of data to manage, we utilized a common data structure for efficient storage and organization of data for both input data and result data. We implemented a block-based method for automated image processing to extract a representative list of plant phenotypic traits. We also provide tools for build-in data plotting and result export. For validation of IAP, we performed an example experiment that contains 33 maize (Zea mays 'Fernandez') plants, which were grown for 9 weeks in an automated greenhouse with nondestructive imaging. Subsequently, the image data were subjected to automated analysis with the maize pipeline implemented in our system. We found that the computed digital volume and number of leaves correlate with our manually measured data in high accuracy up to 0.98 and 0.95, respectively. In summary, IAP provides a multiple set of functionalities for import/export, management, and automated analysis of high-throughput plant phenotyping data, and its analysis results are highly reliable.

  9. Pragmatic Metadata Management for Integration into Multiple Spatial Data Infrastructure Systems and Platforms

    Science.gov (United States)

    Benedict, K. K.; Scott, S.

    2013-12-01

    While there has been a convergence towards a limited number of standards for representing knowledge (metadata) about geospatial (and other) data objects and collections, there exist a variety of community conventions around the specific use of those standards and within specific data discovery and access systems. This combination of limited (but multiple) standards and conventions creates a challenge for system developers that aspire to participate in multiple data infrastrucutres, each of which may use a different combination of standards and conventions. While Extensible Markup Language (XML) is a shared standard for encoding most metadata, traditional direct XML transformations (XSLT) from one standard to another often result in an imperfect transfer of information due to incomplete mapping from one standard's content model to another. This paper presents the work at the University of New Mexico's Earth Data Analysis Center (EDAC) in which a unified data and metadata management system has been developed in support of the storage, discovery and access of heterogeneous data products. This system, the Geographic Storage, Transformation and Retrieval Engine (GSTORE) platform has adopted a polyglot database model in which a combination of relational and document-based databases are used to store both data and metadata, with some metadata stored in a custom XML schema designed as a superset of the requirements for multiple target metadata standards: ISO 19115-2/19139/19110/19119, FGCD CSDGM (both with and without remote sensing extensions) and Dublin Core. Metadata stored within this schema is complemented by additional service, format and publisher information that is dynamically "injected" into produced metadata documents when they are requested from the system. While mapping from the underlying common metadata schema is relatively straightforward, the generation of valid metadata within each target standard is necessary but not sufficient for integration into

  10. Power generation on a solar photovoltaic modules integrated Lighter-than-Air Platform at a low altitude

    CERN Document Server

    Ghosh, Kuntal; Duttagupta, Siddharth P

    2016-01-01

    Use of lighter than air platforms (aerostats and airships) for reconnaissance and surveillance over long periods can be facilitated by generation of power on-board through solar photovoltaic arrays. Attempts to integrate solar photovoltaic modules on such contoured surfaces leads to multiple challenges ranging from the choice of solar modules, determination of best method of their integration with the lighter than air platform, and design of the array layout in order to optimize the loss of power due to non-uniform illumination. This paper describes the method of designing such a system and suggests strategies for overcoming these challenges. The issue of non-uniform illumination has been tackled by maximum power point tracking using the scanning window technique for maximizing power generation and an algorithm of distributed maximum power point tracking has been suggested for further improvement. The procedure described in this paper can be used for obtaining the optimum power generation capability of a sola...

  11. Translational research platforms integrating clinical and omics data: a review of publicly available solutions

    OpenAIRE

    2014-01-01

    The rise of personalized medicine and the availability of high-throughput molecular analyses in the context of clinical care have increased the need for adequate tools for translational researchers to manage and explore these data. We reviewed the biomedical literature for translational platforms allowing the management and exploration of clinical and omics data, and identified seven platforms: BRISK, caTRIP, cBio Cancer Portal, G-DOC, iCOD, iDASH and tranSMART. We analyzed these platforms al...

  12. VOLTTRON™: An Agent Platform for Integrating Electric Vehicles and Smart Grid

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Jereme N.; Akyol, Bora A.; Tenney, Nathan D.; Carpenter, Brandon J.; Pratt, Richard M.; Carroll, Thomas E.

    2013-12-06

    The VOLTTRON™ platform provides a secure environment for the deployment of intelligent applications in the smart grid. VOLTTRON design is based on the needs of control applications running on small form factor devices, namely security and resource guarantees. Services such as resource discovery, secure agent mobility, and interacting with smart and legacy devices are provided by the platform to ease the development of control applications and accelerate their deployment. VOLTTRON platform has been demonstrated in several different domains that influenced and enhanced its capabilities. This paper will discuss the features of VOLTTRON and highlight its usage to coordinate electric vehicle charging with home energy usage

  13. Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass.

    Science.gov (United States)

    Wheeldon, Ian; Christopher, Phillip; Blanch, Harvey

    2017-03-30

    The past decade has seen significant government and private investment in fundamental research and process development for the production of biofuels and chemicals from lignocellulosic biomass-derived sugars. This investment has helped create new metabolic engineering and synthetic biology approaches, novel homogeneous and heterogeneous catalysts, and chemical and biological routes that convert sugars, lignin, and waste products such as glycerol into hydrocarbon fuels and valuable chemicals. With the exception of ethanol, economical biofuels processes have yet to be realized. A potentially viable way forward is the integration of biological and chemical catalysis into processes that exploit the inherent advantages of each technology while circumventing their disadvantages. Microbial fermentation excels at converting sugars from low-cost raw materials streams into simple alcohols, acids, and other reactive intermediates that can be condensed into highly reduced, long and branched chain hydrocarbons and other industrially useful compounds. Chemical catalysis most often requires clean feed streams to avoid catalyst deactivation, but the chemical and petroleum industries have developed large scale processes for C-C coupling, hydrogenation, and deoxygenation that are driven by low grade heat and low-cost feeds such as hydrogen derived from natural gas. In this context, we suggest that there is a reasonably clear route to the high yield synthesis of biofuels from biomass- or otherwise derived-fermentable sugars: the microbial production of reactive intermediates that can be extracted or separated into clean feed stream for upgrading by chemical catalysis. When coupled with new metabolic engineering strategies that maximize carbon and energy yields during fermentation, biomass-to-fuels processes may yet be realized.

  14. Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

    Science.gov (United States)

    Riahi, Reza; Shaegh, Seyed Ali Mousavi; Ghaderi, Masoumeh; Zhang, Yu Shrike; Shin, Su Ryon; Aleman, Julio; Massa, Solange; Kim, Duckjin; Dokmeci, Mehmet Remzi; Khademhosseini, Ali

    2016-04-01

    There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such as ELISA and mass spectroscopy cannot satisfy the needs of continual monitoring as they are labor-intensive and not easily integrable with low-volume bioreactors. This paper reports on the development of an automated microfluidic bead-based electrochemical immunosensor for in-line measurement of cell-secreted biomarkers. For the operation of the multi-use immunosensor, disposable magnetic microbeads were used to immobilize biomarker-recognition molecules. Microvalves were further integrated in the microfluidic immunosensor chip to achieve programmable operations of the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing. The platform allowed convenient integration of the immunosensor with liver-on-chips to carry out continual quantification of biomarkers secreted from hepatocytes. Transferrin and albumin productions were monitored during a 5-day hepatotoxicity assessment in which human primary hepatocytes cultured in the bioreactor were treated with acetaminophen. Taken together, our unique microfluidic immunosensor provides a new platform for in-line detection of biomarkers in low volumes and long-term in vitro assessments of cellular functions in microfluidic bioreactors and organs-on-chips.

  15. Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers.

    Science.gov (United States)

    Riahi, Reza; Shaegh, Seyed Ali Mousavi; Ghaderi, Masoumeh; Zhang, Yu Shrike; Shin, Su Ryon; Aleman, Julio; Massa, Solange; Kim, Duckjin; Dokmeci, Mehmet Remzi; Khademhosseini, Ali

    2016-04-21

    There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such as ELISA and mass spectroscopy cannot satisfy the needs of continual monitoring as they are labor-intensive and not easily integrable with low-volume bioreactors. This paper reports on the development of an automated microfluidic bead-based electrochemical immunosensor for in-line measurement of cell-secreted biomarkers. For the operation of the multi-use immunosensor, disposable magnetic microbeads were used to immobilize biomarker-recognition molecules. Microvalves were further integrated in the microfluidic immunosensor chip to achieve programmable operations of the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing. The platform allowed convenient integration of the immunosensor with liver-on-chips to carry out continual quantification of biomarkers secreted from hepatocytes. Transferrin and albumin productions were monitored during a 5-day hepatotoxicity assessment in which human primary hepatocytes cultured in the bioreactor were treated with acetaminophen. Taken together, our unique microfluidic immunosensor provides a new platform for in-line detection of biomarkers in low volumes and long-term in vitro assessments of cellular functions in microfluidic bioreactors and organs-on-chips.

  16. A central continuous integration platform: Agile Infrastructure use case and future plans

    CERN Document Server

    CERN. Geneva; ANDERSEN, Terje; GEORGIOU, Stefanos

    2014-01-01

    We shall describe the use of Jenkins as a CI solution by the Configuration Team and present the requirements and plans for a central CI platform, as well as the associated challenges and possible solutions.

  17. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform.

    Science.gov (United States)

    Moutsatsos, Ioannis K; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J; Jenkins, Jeremy L; Holway, Nicholas; Tallarico, John; Parker, Christian N

    2017-03-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an "off-the-shelf," open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community.

  18. Development and application of knowledge-based subject group integration platforms:A case study of Shanghai Institute of Ceramics,CAS

    Institute of Scientific and Technical Information of China (English)

    Yu; LIU; Jian; FU; Huijun; ZHENG; Hao; CHEN; Zhiping; YANG

    2014-01-01

    Purpose:According to the different requirements of research group users,we established the knowledge-based subject group integration platforms of Shanghai Institute of Ceramics,the Chinese Academy of Sciences(abbreviated as SIC CAS hereinafter),which were designed and constructed to better meet the needs of CAS research groups for their development,collaboration and communication.Design/methodology/approach:We first identified the requirements of users via preliminary investigation,and then chose CASI1 P,iLibrary and XKE technology,respectively as the building tools compatible with the major demands of users.These steps helped us complete the layout design of SIC CAS integration platforms,as well as its knowledge organization and integration.Findings:According to the need of users,we applied three types of platform construction technologies to five SIC integration platforms,and formulated standard norms for the further construction process,which could provide useful reference for a sustainable development for the extensive construction in CAS institutes.Research limitations:In order to make the SIC integration platforms more intelligent and have more functions,we need to enlarge the scale of the Platforms and upgrade the building tools for the platform construction.Practical implications:The nature of SIC sub-project integration platforms is to construct a content-sensitive environment which can embed knowledge services and knowledge applications seamlessly into scientific activities,so the Platform is expected to be a useful tool to help researchers better understand the recent development of the research field and form collaborations with their peers.Originality/value:SIC integration platforms are the only pilot construction that used 3different platform technologies in the first batch of knowledge-based subject group integration platforms of the Chinese Academy of Sciences.The construction is user-centered throughout the whole process,namely,from the technology

  19. An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin

    Directory of Open Access Journals (Sweden)

    Bo Zhang

    2013-01-01

    Full Text Available The scientific understanding of traditional Chinese medicine (TCM has been hindered by the lack of methods that can explore the complex nature and combinatorial rules of herbal formulae. On the assumption that herbal ingredients mainly target a molecular network to adjust the imbalance of human body, here we present a-self-developed TCM network pharmacology platform for discovering herbal formulae in a systematic manner. This platform integrates a set of network-based methods that we established previously to catch the network regulation mechanism and to identify active ingredients as well as synergistic combinations for a given herbal formula. We then provided a case study on an antirheumatoid arthritis (RA formula, Qing-Luo-Yin (QLY, to demonstrate the usability of the platform. We revealed the target network of QLY against RA-related key processes including angiogenesis, inflammatory response, and immune response, based on which we not only predicted active and synergistic ingredients from QLY but also interpreted the combinatorial rule of this formula. These findings are either verified by the literature evidence or have the potential to guide further experiments. Therefore, such a network pharmacology strategy and platform is expected to make the systematical study of herbal formulae achievable and to make the TCM drug discovery predictable.

  20. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction

    Science.gov (United States)

    Goto, Yusuke; Yanagi, Itaru; Matsui, Kazuma; Yokoi, Takahide; Takeda, Ken-Ichi

    2016-08-01

    The practical use of solid-state nanopores for DNA sequencing requires easy fabrication of the nanopores, reduction of the DNA movement speed and reduction of the ionic current noise. Here, we report an integrated nanopore platform with a nanobead structure that decelerates DNA movement and an insulating polyimide layer that reduces noise. To enable rapid nanopore fabrication, we introduced a controlled dielectric breakdown (CDB) process into our system. DNA translocation experiments revealed that single nanopores were created by the CDB process without sacrificing performance in reducing DNA movement speed by up to 10 μs/base or reducing noise up to 600 pArms at 1 MHz. Our platform provides the essential components for proceeding to the next step in the process of DNA sequencing.

  1. Catalyst-Free Vapor-Phase Method for Direct Integration of Gas Sensing Nanostructures with Polymeric Transducing Platforms

    Directory of Open Access Journals (Sweden)

    Stella Vallejos

    2014-01-01

    Full Text Available Tungsten oxide nanoneedles (NNs are grown and integrated directly with polymeric transducing platforms for gas sensors via aerosol-assisted chemical vapor deposition (AACVD method. Material analysis shows the feasibility to grow highly crystalline nanomaterials in the form of NNs with aspect ratios between 80 and 200 and with high concentration of oxygen vacancies at the surface, whereas gas testing demonstrates moderate sensing responses to hydrogen at concentrations between 10 ppm and 50 ppm, which are comparable with results for tungsten oxide NNs grown on silicon transducing platforms. This method is demonstrated to be an attractive route to fabricate next generation of gas sensors devices, provided with flexibility and functionality, with great potential in a cost effective production for large-scale applications.

  2. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms.

    Science.gov (United States)

    Stathakarou, Natalia; Zary, Nabil; Kononowicz, Andrzej A

    2014-01-01

    Background. Massive Open Online Courses (MOOCs) are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach. Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a "proof-of-concept" prototype. The resulting pilot implementation was subject of verification by two test cases. Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified. Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  3. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms

    Directory of Open Access Journals (Sweden)

    Natalia Stathakarou

    2014-11-01

    Full Text Available Background. Massive Open Online Courses (MOOCs are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation.Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach.Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a “proof-of-concept” prototype. The resulting pilot implementation was subject of verification by two test cases.Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified.Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  4. A Integrated Service Platform for Remote Sensing Image 3D Interpretation and Draughting based on HTML5

    Science.gov (United States)

    LIU, Yiping; XU, Qing; ZhANG, Heng; LV, Liang; LU, Wanjie; WANG, Dandi

    2016-11-01

    The purpose of this paper is to solve the problems of the traditional single system for interpretation and draughting such as inconsistent standards, single function, dependence on plug-ins, closed system and low integration level. On the basis of the comprehensive analysis of the target elements composition, map representation and similar system features, a 3D interpretation and draughting integrated service platform for multi-source, multi-scale and multi-resolution geospatial objects is established based on HTML5 and WebGL, which not only integrates object recognition, access, retrieval, three-dimensional display and test evaluation but also achieves collection, transfer, storage, refreshing and maintenance of data about Geospatial Objects and shows value in certain prospects and potential for growth.

  5. Creation of an Integrated Environment to Supply e-Learning Platforms with Office Automation Features

    Science.gov (United States)

    Palumbo, Emilio; Verga, Francesca

    2015-01-01

    Over the last years great efforts have been made within the University environment to implement e-learning technologies in the standard educational practice. These learning technologies distribute online educational multimedia contents through technological platforms. Even though specific e-learning tools for technical disciplines were already…

  6. An Integrated Library Platform: Wales' Approach to Delivering Digital Information and Resources Nationally

    Science.gov (United States)

    Bevan, Paul; Tyler, Alyson

    2009-01-01

    Purpose: This paper aims to outline the developments and strategies employed to supply online library services in Wales through a national platform: library.wales.org These services include: the "Cat Cymru" cross-catalogue search, centrally procured subscription resources and local library microsites. Design/methodology/approach: The…

  7. More Sustainable Participation? Multi-Stakeholder Platforms for Integrated Catchment Management

    NARCIS (Netherlands)

    Warner, J.F.

    2006-01-01

    This paper argues for realistic expectations of Multi-Stakeholder Platforms (MSPs). MSPs are currently a hot topic in the water policy community, despite voices of disillusionment with participation in development work. Research carried out in Peru, Argentina, India, South Africa and Belgium suggest

  8. Integration of the program TNXYZ in the platform SALOME; Integracion del programa TNXYZ en la plataforma SALOME

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.; Silva A, L.; Del Valle G, E. [IPN, Escuela Superior de Fisica y Matematicas, Av. Instituto Politecnico Nacional s/n, U.P. Adolfo Lopez Mateos, Edificio 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico); Gomez T, A. M.; Vargas E, S., E-mail: javier.paquito@hotmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2013-10-15

    This work presents the procedure realized to integrate the code TNXYZ like a processing tool to the graphic simulation platform SALOME. The code TNXYZ solves the neutron transport equation in stationary state, for several energy groups, quantizing the angular variable by the discrete ordinates method and the space variable by nodal methods. The platform SALOME is a graphic surrounding designed for the construction, edition and simulation of mechanical models focused to the industry and contrary to other software, it allows to integrate external source codes to the surrounding, to form a complete scheme of execution, supervision, pre and post information processing. The code TNXYZ was programmed in the 90s in a Fortran compiler, but to be used at the present time the code should be actualized to the current compiler characteristics; also, in the original scheme was carried out a modularization process, that is to say, the main program was divided in sections where the code carries out important operations, with the intention of flexibility the data extraction process along its processing sequence and that can be useful in a later development of coupling. Finally, to verify the integration a fuel assembly BWR was modeled, as well as a control cell. The cross sections were obtained with the Monte Carlo Serpent code. Some results obtained with Serpent were used to verify and to begin with the validation of the code, being obtained an acceptable comparison in the infinite multiplication factor. The validation process should extend and one has planned to present in a future work. This work is part of the development of the research group formed between the Escuela Superior de Fisica y Matematicas del Instituto Politecnico Nacional (IPN) and the Instituto Nacional de Investigaciones Nucleares (ININ) in which a simulation Mexican platform of nuclear reactors is developed. (Author)

  9. The Western States Water Mission: A Hyper-Resolution Hydrological Modeling and Data Integration Platform

    Science.gov (United States)

    Famiglietti, James; Basilio, Ralph; Trangsrud, Amy; Andreadis, Kostas; Cricthon, Dan; David, Cedric; Farr, Thomas; Malhotra, Shan; Neff, Kirstin; Reager, John

    2016-04-01

    Hydrological remote sensing has advanced significantly over the last decade, and will continue to grow with number of recent and near-future launched. Arguably, a platform for synthesizing remote observations is an important step towards improved modeling, understanding and prediction of terrestrial hydrology. In this presentation we describe the new NASA Western States Water Mission, a high-resolution, catchment-based modeling and data assimilation platform implemented for the western United States. Model structure will be described, as well as early results that include assimilation of satellite snow observations. A key feature of model development has been its treatment as a 'flight project' which enables leveraging of important NASA systems engineering and project management expertise.

  10. Supporting Medical Research on Chronic Diseases using Integrated Health Monitoring Platform

    OpenAIRE

    Krukowski, Artur; Vogiatzaki, Emmanouela; Charalambides, Marios; Chouchoulis, Michalis

    2014-01-01

    This paper describes combined experiences in developing e-Health platforms and services with respect of supporting medical research into the causes and relationships among physiological parameters and health problems concerning different chronic diseases, from cardiovascular to stroke, epilepsy, and others. The Personal Health Records (PHR) is presented as new technological approaches aimed at standardizing electronic management of medical information between the patient and its physicians, a...

  11. End-to-end integrated security and performance analysis on the DEGAS Choreographer platform

    DEFF Research Database (Denmark)

    Buchholtz, Mikael; Gilmore, Stephen; Haenel, Valentin

    2005-01-01

    with the analysers of the calculi, and the results of the analysis are reflected back into a modified version of the input UML model. The design platform supporting the methodology, Choreographer, interoperates with state-of-the-art UML modelling tools. We illustrate the approach with a well known protocol...... and report on the experience of industrial users who have applied Choreographer in their development work....

  12. Modeling platform for integrated assessment of intervention propolsals in localities : case study, Medellin Metropolitan Area (Colombia)

    OpenAIRE

    2011-01-01

    This dissertation proposes a comprehensive framework for conceptual, methodological and instrumental contribution to urban intervention planning and public policy design. For a Latin American case study, a prospective multi-methodology modeling platform was developed to support the novel proposed approaches for intervention assessment, as well as to establish a knowledge building dynamic for planners using multidisciplinary discussion and, most importantly, paradigm confrontation and change. ...

  13. p-medicine: a medical informatics platform for integrated large scale heterogeneous patient data

    OpenAIRE

    Marés, J.; Shamardin, L.; Weiler, G.; Anguita Sanchez, Alberto; Sfakianakis, S.; Neri, E.; Zasada, S. J.; Graf, Norbert; Coveney, P. V.

    2014-01-01

    Secure access to patient data is becoming of increasing importance, as medical informatics grows in significance, to both assist with population health studies, and patient specific medicine in support of treatment. However, assembling the many different types of data emanating from the clinic is in itself a difficulty, and doing so across national borders compounds the problem. In this paper we present our solution: an easy to use distributed informatics platform embedding a state of the art...

  14. Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform.

    Directory of Open Access Journals (Sweden)

    Yanli Liu

    Full Text Available Heterogeneity in responses of cells to a stimulus, such as a pathogen or allergen, can potentially play an important role in deciding the fate of the responding cell population and the overall systemic response. Measuring heterogeneous responses requires tools capable of interrogating individual cells. Cell signaling studies commonly do not have single-cell resolution because of the limitations of techniques used such as Westerns, ELISAs, mass spectrometry, and DNA microarrays. Microfluidics devices are increasingly being used to overcome these limitations. Here, we report on a microfluidic platform for cell signaling analysis that combines two orthogonal single-cell measurement technologies: on-chip flow cytometry and optical imaging. The device seamlessly integrates cell culture, stimulation, and preparation with downstream measurements permitting hands-free, automated analysis to minimize experimental variability. The platform was used to interrogate IgE receptor (FcεRI signaling, which is responsible for triggering allergic reactions, in RBL-2H3 cells. Following on-chip crosslinking of IgE-FcεRI complexes by multivalent antigen, we monitored signaling events including protein phosphorylation, calcium mobilization and the release of inflammatory mediators. The results demonstrate the ability of our platform to produce quantitative measurements on a cell-by-cell basis from just a few hundred cells. Model-based analysis of the Syk phosphorylation data suggests that heterogeneity in Syk phosphorylation can be attributed to protein copy number variations, with the level of Syk phosphorylation being particularly sensitive to the copy number of Lyn.

  15. A CMOS-compatible silicon photonic platform for high-speed integrated opto-electronics

    Science.gov (United States)

    Galland, Christophe; Novack, Ari; Liu, Yang; Ding, Ran; Gould, Michael; Baehr-Jones, Tom; Li, Qi; Yang, Yisu; Ma, Yangjin; Zhang, Yi; Padmaraju, Kishore; Bergmen, Keren; Lim, Andy Eu-Jin; Lo, Guo-Qiang; Hochberg, Michael

    2013-05-01

    We have developed a CMOS-compatible Silicon-on-Insulator photonic platform featuring active components such as pi- n and photoconductive (MIM) Ge-on-Si detectors, p-i-n ring and Mach-Zehnder modulators, and traveling-wave modulators based on a p-n junction driven by an RF transmission line. We have characterized the yield and uniformity of the performance through automated cross-wafer testing, demonstrating that our process is reliable and scalable. The entire platform is capable of more than 40 GB/s data rate. Fabricated at the IME/A-STAR foundry in Singapore, it is available to the worldwide community through OpSIS, a successful multi-project wafer service based at the University of Delaware. After exposing the design, fabrication and performance of the most advanced platform components, we present our newest results obtained after the first public run. These include low loss passives (Y-junctions: 0.28 dB; waveguide crossings: 0.18 dB and cross-talk -41+/-2 dB; non-uniform grating couplers: 3.2+/-0.2 dB). All these components were tested across full 8" wafers and exhibited remarkable uniformity. The active devices were improved from the previous design kit to exhibit 3dB bandwidths ranging from 30 GHz (modulators) to 58 GHz (detectors). We also present new packaging services available to OpSIS users: vertical fiber coupling and edge coupling.

  16. Ocean Thermal Energy Conversion (OTEC) platform configuration and integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Scott, R. J.

    1978-07-01

    Studies leading to the development of conceptual designs for two 400 MW Offshore Thermal Energy Conversion (OTEC) Commercial Plants are summarized. A detailed overview of the study Final Report which was completed in Jun 1978 is presented. The successful deployment of a Commercial OTEC Plant in the near term is dependent upon the optimization of the platform configuration and power plant output level. The optimization procedure is based on both technical and economic factors and is used to evaluate a relatively large number of alternatives; i.e., six hullforms, five plant outputs ranging from 50 to 500 megawatts (MW), and three deployment sites. The hullforms under consideration include the ship (barge), cylinder (disc), spar, submersible, semi-submersible, and sphere; while the deployment sites are Hawaii, New Orleans, and Key West. The second part of the Summary describes the development of the two platforms selected by DOE to be carried through the Conceptual Design level: a 400 MW ship and semi-submersible. These studies include platform and cold water pipe (CWP) optimization trade-offs, arrangements, structure, position control, seawater systems, and auxiliary systems. Deployment concepts are also discussed, followed by definition of costs and schedules for both alternatives. A development plan to bring both Commercial Plant alternatives to fruition via an intermediate 100 MW Demonstration Plant which will reduce technical risks to an acceptable level is presented.

  17. Design of the Hospital Integrated Information Management System Based on Cloud Platform

    OpenAIRE

    Aijing, L; Jin, Y.

    2015-01-01

    At present, the outdated information management style cannot meet the needs of hospital management, and has become the bottleneck of hospital's management and development. In order to improve the integrated management of information, hospitals have increased their investment in integrated information management systems. On account of the lack of reasonable and scientific design, some hospital integrated information management systems have common problems, such as unfriendly interface, poor po...

  18. A heterogeneous III-V/silicon integration platform for on-chip quantum photonic circuits with single quantum dot devices

    CERN Document Server

    Davanco, Marcelo; Sapienza, Luca; Zhang, Chen-Zhao; Cardoso, Jose Vinicius De Miranda; Verma, Varun; Mirin, Richard; Nam, Sae Woo; Liu, Liu; Srinivasan, Kartik

    2016-01-01

    Photonic integration is an enabling technology for photonic quantum science, offering greater scalability, stability, and functionality than traditional bulk optics. Here, we describe a scalable, heterogeneous III-V/silicon integration platform to produce Si$_3$N$_4$ photonic circuits incorporating GaAs-based nanophotonic devices containing self-assembled InAs/GaAs quantum dots. We demonstrate pure singlephoton emission from individual quantum dots in GaAs waveguides and cavities - where strong control of spontaneous emission rate is observed - directly launched into Si$_3$N$_4$ waveguides with > 90 % efficiency through evanescent coupling. To date, InAs/GaAs quantum dots constitute the most promising solidstate triggered single-photon sources, offering bright, pure and indistinguishable emission that can be electrically and optically controlled. Si$_3$N$_4$ waveguides offer low-loss propagation, tailorable dispersion and high Kerr nonlinearities, desirable for linear and nonlinear optical signal processing d...

  19. Thermo-Economic Modelling and Process Integration of CO2-Mitigation Options on Oil and Gas Platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter

    2014-01-01

    The offshore extraction of oil and gas is an energy-intensive process associated with large CO2 and CH4 emissions to the atmosphere and chemicals to the sea. The taxation of these emissions has encouraged the development of more energy-efficient and environmental-friendly solutions, of which three...... are assessed in this paper. The integration of steam bottoming cycles on the gas turbines or of lowtemperature power cycles on the export gas compression can result either in an additional power output, or in a greater export of natural gas. Another possibility is to implement a CO2-capture unit, which allows...... recovering CO2 that can be used for enhanced oil recovery. In this paper, a North Sea platform is considered as case study, and the site-scale retrofit integration of these three options is analysed, considering thermodynamic, economic and environmental performance indicators. The results illustrate...

  20. Arsenic removal from contaminated groundwater by membrane-integrated hybrid plant: optimization and control using Visual Basic platform.

    Science.gov (United States)

    Chakrabortty, S; Sen, M; Pal, P

    2014-03-01

    A simulation software (ARRPA) has been developed in Microsoft Visual Basic platform for optimization and control of a novel membrane-integrated arsenic separation plant in the backdrop of absence of such software. The user-friendly, menu-driven software is based on a dynamic linearized mathematical model, developed for the hybrid treatment scheme. The model captures the chemical kinetics in the pre-treating chemical reactor and the separation and transport phenomena involved in nanofiltration. The software has been validated through extensive experimental investigations. The agreement between the outputs from computer simulation program and the experimental findings are excellent and consistent under varying operating conditions reflecting high degree of accuracy and reliability of the software. High values of the overall correlation coefficient (R (2) = 0.989) and Willmott d-index (0.989) are indicators of the capability of the software in analyzing performance of the plant. The software permits pre-analysis, manipulation of input data, helps in optimization and exhibits performance of an integrated plant visually on a graphical platform. Performance analysis of the whole system as well as the individual units is possible using the tool. The software first of its kind in its domain and in the well-known Microsoft Excel environment is likely to be very useful in successful design, optimization and operation of an advanced hybrid treatment plant for removal of arsenic from contaminated groundwater.

  1. An Integrated Platform for Dynamic Software Updating and its Application in Self-* systems

    DEFF Research Database (Denmark)

    Gregersen, Allan Raundahl; Jørgensen, Bo Nørregaard; Hadaytullah;

    2012-01-01

    Practical dynamic updating of modern Java applications requires tool support to become an integral part of the software development and maintenance lifecycle. In this paper we present Javeleon, an easy-to-use tool for dynamic updates of Java applications. To support integration with specific...

  2. BNDB – The Biochemical Network Database

    Directory of Open Access Journals (Sweden)

    Kaufmann Michael

    2007-10-01

    Full Text Available Abstract Background Technological advances in high-throughput techniques and efficient data acquisition methods have resulted in a massive amount of life science data. The data is stored in numerous databases that have been established over the last decades and are essential resources for scientists nowadays. However, the diversity of the databases and the underlying data models make it difficult to combine this information for solving complex problems in systems biology. Currently, researchers typically have to browse several, often highly focused, databases to obtain the required information. Hence, there is a pressing need for more efficient systems for integrating, analyzing, and interpreting these data. The standardization and virtual consolidation of the databases is a major challenge resulting in a unified access to a variety of data sources. Description We present the Biochemical Network Database (BNDB, a powerful relational database platform, allowing a complete semantic integration of an extensive collection of external databases. BNDB is built upon a comprehensive and extensible object model called BioCore, which is powerful enough to model most known biochemical processes and at the same time easily extensible to be adapted to new biological concepts. Besides a web interface for the search and curation of the data, a Java-based viewer (BiNA provides a powerful platform-independent visualization and navigation of the data. BiNA uses sophisticated graph layout algorithms for an interactive visualization and navigation of BNDB. Conclusion BNDB allows a simple, unified access to a variety of external data sources. Its tight integration with the biochemical network library BN++ offers the possibility for import, integration, analysis, and visualization of the data. BNDB is freely accessible at http://www.bndb.org.

  3. WormBase as an Integrated Platform for the C. elegans ORFeome

    OpenAIRE

    Chen, Nansheng; Lawson, Daniel; Bradnam, Keith; Harris, Todd W.; Stein, Lincoln D.

    2004-01-01

    The ORFeome project has validated and corrected a large number of predicted gene models in the nematode C. elegans, and has provided an enormous resource for proteome-scale studies. To make the resource useful to the research and teaching community, it needs to be integrated with other large-scale data sets, including the C. elegans genome, cell lineage, neurological wiring diagram, transcriptome, and gene expression map. This integration is also critical because the ORFeome data sets, like o...

  4. Integration Between SCORM Learning Objects and the CIEMAT Virtual Elearning Platform; Integracion de Objetos de Aprendizaje SCORM con la Plataforma de Ensenanza Virtual del CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Bailador Ferreras, M. A.; Troiani, S.; Gonzalez Giralda, C.; Llorente Herranz, C.; Marco Arboli, M. L.

    2010-08-06

    New information and communications technologies have made a major contribution in the way of understanding the training needs, which have been involved in the change from the traditional teaching to the use of virtual learning platforms. Thus, Ciemat, has installed a virtual platform for education, in particular MOODLE in which have been installed some virtual contents developed with Flash. The next necessary step has been how to integrate the contents with the MOODLE virtual platform, following the aim to know the assessment for learning tracking of the learners. This document provides the technological facts for the integration of the flash virtual contents and the virtual platform in order to achieve the training process is efficiently evaluated. (Author) 5 refs.

  5. Integrated Cu-based TM-pass polarizer using CMOS technology platform

    KAUST Repository

    Ng, Tien Khee

    2010-01-01

    A transverse-magnetic-pass (TM-pass) copper (Cu) polarizer is proposed and analyzed using the previously published two-dimensional Method-of-Lines beam-propagation model. The proposed polarizer exhibits a simulated high-pass filter characteristics, with TM0 and TE0 mode transmissivity of >70% and <5%, respectively, in the wavelength regime of 1.2-1.6 μm. The polarization extinction ratio (PER) given by 10 log10 (PTM0)/(PTE0) is +11.5 dB across the high-pass wavelength regime. To the best of the authors\\' knowledge, we report here the smallest footprint CMOS-platform compatible TM-polarizer.

  6. Fabrication of an infrared emitter using a generic integration platform based on wire bonding

    Science.gov (United States)

    Schröder, S.; Rödjegård, H.; Fischer, A. C.; Stemme, G.; Niklaus, F.

    2016-11-01

    This paper reports a novel approach for the fabrication of infrared (IR) emitters for non-dispersive IR gas sensing. The proposed concept enables the integration of superior resistive heater materials with microelectromechanical system structures. In this study, non-bondable filaments made of nickel chromium are attached to mechanical attachment structures using a fully automated state-of-the-art wire bonder. Formation of electrical contact between the integrated filaments and the electrical contact pattern on the substrate is performed using conventional gold stud bumping technology. The placement accuracy of the integrated filaments is evaluated using white-light interferometry, while the contact formation using stud bumping to embed the filaments is investigated using focused ion beam milled cross-sections. A proof-of-concept IR emitter has been successfully operated and heated up to {{960}\\circ}\\text{C} in continuous mode for 3 h.

  7. Giant enhancement of light emission from Au nanocrystals into a porous matrix integrated with silicon platform.

    Science.gov (United States)

    Kisner, Alexandre; de Aguiar, Marina Rodrigues; Kubota, Lauro T

    2009-04-01

    Integration of metal nanoparticle-dielectric films with silicon technology is emerging as a promising candidate for sub-wavelength optoelectronics and correlated devices. A giant enhancement of the luminescence intensity of gold nanocrystals directly prepared on a nanoporous template of anodized aluminium oxide is evaluated herewith, for the first time in literature, as a favourable substrate for integrating silicon-based optoelectronics. The size and lateral separation between adjacent particles are controlled by the geometry of the dielectric matrix and on-chip-integration is achieved during the nanoparticle growth, requiring no further steps. A more pronounced photoresponse is observed with embedded nanocrystals as small as 12 nm and the high emission is attributed to the light confinement associated to the increase of the local field effect on the surface plasmon hybridization waves. The demonstrated ability to control the assemble of the nanocrystals and the intense light emission indicate that the embedded gold nanostructures have a high potential for plasmonic device applications.

  8. Life performance of oil and gas platforms: Site integration and thermodynamic evaluation

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Fülöp, Tamás Gábor; Breuhaus, Peter

    2014-01-01

    requirements are assessed by a process integration study, and the system inefficiencies are pinpointed by performing an exergy accounting. The heating and cooling requirements vary significantly over time, and most inefficiencies take place in processes where chemical exergy is consumed (50-55%), thermal...... exergy is transferred (15-20%), or mechanical exergy is varied (10-15%). These findings are valid for all production periods: this suggests that more attention should be paid on a proper integration of the processing and utility plants, by, for instance, recovering heat from the turbine exhausts and from...

  9. Electro pneumatic trainer embedded with programmable integrated circuit (PIC) microcontroller and graphical user interface platform for aviation industries training purposes

    Science.gov (United States)

    Burhan, I.; Azman, A. A.; Othman, R.

    2016-10-01

    An electro pneumatic trainer embedded with programmable integrated circuit (PIC) microcontroller and Visual Basic (VB) platform is fabricated as a supporting tool to existing teaching and learning process, and to achieve the objectives and learning outcomes towards enhancing the student's knowledge and hands-on skill, especially in electro pneumatic devices. The existing learning process for electro pneumatic courses conducted in the classroom does not emphasize on simulation and complex practical aspects. VB is used as the platform for graphical user interface (GUI) while PIC as the interface circuit between the GUI and hardware of electro pneumatic apparatus. Fabrication of electro pneumatic trainer interfacing between PIC and VB has been designed and improved by involving multiple types of electro pneumatic apparatus such as linear drive, air motor, semi rotary motor, double acting cylinder and single acting cylinder. Newly fabricated electro pneumatic trainer microcontroller interface can be programmed and re-programmed for numerous combination of tasks. Based on the survey to 175 student participants, 97% of the respondents agreed that the newly fabricated trainer is user friendly, safe and attractive, and 96.8% of the respondents strongly agreed that there is improvement in knowledge development and also hands-on skill in their learning process. Furthermore, the Lab Practical Evaluation record has indicated that the respondents have improved their academic performance (hands-on skills) by an average of 23.5%.

  10. WELCOME – innovative integrated care platform using wearable sensing and smart cloud computing for COPD patients with comorbidities.

    Science.gov (United States)

    Chouvarda, Ioanna; Philip, Nada Y; Natsiavas, Pantelis; Kilintzis, Vasilis; Sobnath, Drishty; Kayyali, Reem; Henriques, Jorge; Paiva, Rui Pedro; Raptopoulos, Andreas; Chételat, Olivier; Maglaveras, Nicos

    2014-01-01

    We propose WELCOME, an innovative integrated care platform using wearable sensors and smart cloud computing for Chronic Obstructive Pulmonary Disease (COPD) patients with co-morbidities. WELCOME aims to bring about a change in the reactive nature of the management of chronic diseases and its comorbidities, in particular through the development of a patient centred and proactive approach to COPD management. The aim of WELCOME is to support healthcare services to give early detection of complications (potentially reducing hospitalisations) and the prevention and mitigation of comorbidities (Heart Failure, Diabetes, Anxiety and Depression). The system incorporates patient hub, where it interacts with the patient via a light vest including a large number of non-invasive chest sensors for monitoring various relevant parameters. In addition, interactive applications to monitor and manage diabetes, anxiety and lifestyle issues will be provided to the patient. Informal carers will also be supported in dealing with their patients. On the other hand, welcome smart cloud platform is the heart of the proposed system where all the medical records and the monitoring data are managed and processed via the decision support system. Healthcare professionals will be able to securely access the WELCOME applications to monitor and manage the patient's conditions and respond to alerts on personalized level.

  11. Integration proposal through standard-based design of an end-to-end platform for p-Health environments.

    Science.gov (United States)

    Martíínez, I; Trigo, J D; Martínez-Espronceda, M; Escayola, J; Muñoz, P; Serrano, L; García, J

    2009-01-01

    Interoperability among medical devices and compute engines in the personal environment of the patient, and with healthcare information systems in the remote monitoring and management process is a key need that requires developments supported on standard-based design. Even though there have been some international initiatives to combine different standards, the vision of an entire end-to-end standard-based system is the next challenge. This paper presents the implementation guidelines of a ubiquitous platform for Personal Health (p-Health). It is standard-based using the two main medical norms in this context: ISO/IEEE11073 in the patient environment for medical device interoperability, and EN13606 to allow the interoperable communication of the Electronic Healthcare Record of the patient. Furthermore, the proposal of a new protocol for End-to-End Standard Harmonization (E2ESHP) is presented in order to make possible the end-to-end standard integration. The platform has been designed to comply with the last ISO/IEEE11073 and EN13606 available versions, and tested in a laboratory environment as a proof-of-concept to illustrate its feasibility as an end-to-end standard-based solution.

  12. SenSyF Experience on Integration of EO Services in a Generic, Cloud-Based EO Exploitation Platform

    Science.gov (United States)

    Almeida, Nuno; Catarino, Nuno; Gutierrez, Antonio; Grosso, Nuno; Andrade, Joao; Caumont, Herve; Goncalves, Pedro; Villa, Guillermo; Mangin, Antoine; Serra, Romain; Johnsen, Harald; Grydeland, Tom; Emsley, Stephen; Jauch, Eduardo; Moreno, Jose; Ruiz, Antonio

    2016-08-01

    SenSyF is a cloud-based data processing framework for EO- based services. It has been pioneer in addressing Big Data issues from the Earth Observation point of view, and is a precursor of several of the technologies and methodologies that will be deployed in ESA's Thematic Exploitation Platforms and other related systems.The SenSyF system focuses on developing fully automated data management, together with access to a processing and exploitation framework, including Earth Observation specific tools. SenSyF is both a development and validation platform for data intensive applications using Earth Observation data. With SenSyF, scientific, institutional or commercial institutions developing EO- based applications and services can take advantage of distributed computational and storage resources, tailored for applications dependent on big Earth Observation data, and without resorting to deep infrastructure and technological investments.This paper describes the integration process and the experience gathered from different EO Service providers during the project.

  13. The integration of 3D carbon-electrode dielectrophoresis on a CD-like centrifugal microfluidic platform.

    Science.gov (United States)

    Martinez-Duarte, Rodrigo; Gorkin, Robert A; Abi-Samra, Kameel; Madou, Marc J

    2010-04-21

    We introduce the integration of a novel dielectrophoresis (DEP)-assisted filter with a compact disk (CD)-based centrifugal platform. Carbon-electrode dielectrophoresis (carbon-DEP) refers to the use of carbon electrodes to induce DEP. In this work, 3D carbon electrodes are fabricated using the C-MEMS technique and are used to implement a DEP-enabled active filter to trap particles of interest. Compared to traditional planar metal electrodes, 3D carbon electrodes allow for superior filtering efficiency. The system includes mounting modular 3D carbon-DEP chips on an electrically interfaced rotating disk. This allows simple centrifugal pumping to replace the large footprint syringe pump approaches commonly used in DEP systems. The advantages of the CD setup include not only a reduced footprint, but also complexity and cost reduction by eliminating expensive precision pumps and fluidic interconnects. To demonstrate the viability of this system we quantified the filter efficiency in the DEP trapping of yeast cells from a mix of latex and yeast cells. Results demonstrate selective filtering at flow rates up to 35 microl min(-1). The impact of electrode height, DEP chip misalignment and particle sedimentation on filter efficiency and the advantages this system represents are analyzed. The ultimate goal is to obtain an automated platform for bioparticle sorting with application in different fields such as point-of-care diagnostics and cell-based therapies.

  14. The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services and the challenge of integrating social sciences and humanities

    Directory of Open Access Journals (Sweden)

    Stenseke Marie

    2016-09-01

    Full Text Available For the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES, established in 2012, under the auspices of four United Nations entities (FAO, UNDP, UNEP and UNESCO, there is an urgent need to engage scholars in social sciences and humanities in assessing the state of the planet’s biodiversity. This article addresses the fundaments for involving scientists from these fields of science in IPBES, and reflects on the existing barriers. It builds on previous research on IPBES from various perspectives, as well as on the author’s insights from work in the organization. A fundamental condition recognized is that there needs to be a qualified understanding of what it means to integrate natural sciences and social sciences/humanities, and also that the latter have to be accepted on their own terms. Other barriers are related to the contextualisation of biodiversity issues and the more politically sensitive character of research carried out in social sciences and humanities. In the conclusions it is emphasized that the deliverables of the first round of IPBES assessments have to be solid enough from the perspectives of social sciences and humanities, in order to attract more of these scholars to work for the platform in the future.

  15. Integrated Biological Warfare Technology Platform (IBWTP). Intelligent Software Supporting Situation Awareness, Response, and Operations

    Science.gov (United States)

    2007-01-01

    21 4.3.1. Existing Biosurveillance Systems .............................................................. 22 4.3.2. Automatic Integration...Expert Team Risk Assessment Emergency Plans Command Centers IPE – Intelligent Portal - IPE Interactive Knowledge Wall Presentation Collaboration...such as existing biosurveillance systems, information produced via technological approaches can be incorporated into IBWTP in a fairly transparent

  16. Perfusion-based three dimensional (3D) tissue engineering platform with integrated bioimpedance sensing

    DEFF Research Database (Denmark)

    Muhammad, Haseena Bashir; Canali, Chiara; Heiskanen, Arto

    2014-01-01

    We present an 8-channel bioreactor array with integrated bioimpedance sensors, which enables perfusion culture of cells seeded onto porous 3D scaffolds. Results show the capability of the system for monitoring cell proliferation within the scaffolds through a culture period of 19 days....

  17. BiGG Models: A platform for integrating, standardizing and sharing genome-scale models

    DEFF Research Database (Denmark)

    2016-01-01

    Genome-scale metabolic models are mathematically-structured knowledge bases that can be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can generate and test hypotheses when integrated with experimental data. To maximize the value of these models, centralized...

  18. Integrated microfluidic platform for bilayer studies and experimentation on single pore-forming species

    NARCIS (Netherlands)

    Stimberg, V.C.; Berg, van den A.; Le Gac, S.

    2011-01-01

    The combination of microfluidics with BLMs (bilayer lipid membranes) consists of a powerful tool for multiplexed and high-throughput studies on membrane properties and membrane proteins. Here, we report an integrated device for BLM ex-perimentation using both optical and electrical measurements. Thi

  19. Integrative platform based on the mechatronics model for educational technologies focused on competence

    Science.gov (United States)

    Vlaşin, I.; Greta, S.; Dache, L.; Mătieş, V.

    2016-08-01

    Mechatronics is a model of transdisciplinary integration, entirely functional, with remarkable results for mankind. The incredible progress that the global economy has taken in the last decades is based on this new approach, the integrative type, which is present at the foundation of mechatronics. This kind of integrative approach is necessary for building a quality education focused on competence. The requirements from the social and economic environment, the needs of the young people who prepare themselves for an active life and the offers of the education providers are still not too interconnected to offer a satisfying education. This is the reason why the efforts to balance the demand, the needs and the offer are essential to ensure a better integration of students into society. Using a transcultural perspective, we can achieve a constructive approach. The education providers, together with the socio-economic environment, establish a clear structure of competence in multiple domains and of the instruments which can assure it. The scientific demarche, in the spirit of this paper approach the, answers the natural questions from the educational process: „Why, How and What do I learn?”.

  20. 一种基于SOA的企业集成平台%SOA-based Enterprise Integration Platform

    Institute of Scientific and Technical Information of China (English)

    张朝晖; 徐立臻; 董逸生; 徐宏炳

    2011-01-01

    An SOA-based enterprise integration platform called JSSOA is presented.Cored on Enterprise Service Integration(ESI) middleware,JSSOA supports transparent integration of heterogeneous systems and services, MDA-based and business user oriented process modeling and service composition, semantic and QoS based service finding and service oriented UI creating.JSSOA simplifies the creation, running and maintenance of SOA-based applications by encapsulating the complicate details of SOA technology.%提出一种基于SOA的企业集成平台--JSSOA,以企业服务集成中间件为核心,实现异构系统和多种类型服务的透明集成,支持基于MDA方法面向最终用户的流程建模和服务组合、基于语义及QoS的服务查找、基于服务的个性化应用系统用户界面创制.该平台封装了复杂的SOA技术细节,使基于SOA的应用系统的构建、运行和维护更简单、高效.

  1. Investigating the Nexus of Climate, Energy, Water, and Land at Decision-Relevant Scales: The Platform for Regional Integrated Modeling and Analysis (PRIMA)

    Energy Technology Data Exchange (ETDEWEB)

    Kraucunas, Ian P.; Clarke, Leon E.; Dirks, James A.; Hathaway, John E.; Hejazi, Mohamad I.; Hibbard, Kathleen A.; Huang, Maoyi; Jin, Chunlian; Kintner-Meyer, Michael C.W.; Kleese van Dam, Kerstin; Leung, Lai-Yung R.; Li, Hongyi; Moss, Richard H.; Peterson, Marty J.; Rice, Jennie S.; Scott, Michael J.; Thomson, Allison M.; Voisin, Nathalie; West, Tristram O.

    2015-04-01

    The Platform for Regional Integrated Modeling and Analysis (PRIMA) is an innovative modeling system developed at Pacific Northwest National Laboratory (PNNL) to simulate interactions among natural and human systems at scales relevant to regional decision making. PRIMA brings together state-of-the-art models of regional climate, hydrology, agriculture, socioeconomics, and energy systems using a flexible coupling approach. The platform can be customized to inform a variety of complex questions and decisions, such as the integrated evaluation of mitigation and adaptation options across a range of sectors. Research into stakeholder decision support needs underpins the platform's application to regional issues, including uncertainty characterization. Ongoing numerical experiments are yielding new insights into the interactions among human and natural systems on regional scales with an initial focus on the energy-land-water nexus in the upper U.S. Midwest. This paper focuses on PRIMA’s functional capabilities and describes some lessons learned to date about integrated regional modeling.

  2. Human health impacts for renewable energy scenarios from the EnerGEO Platform of Integrated Assessment (PIA)

    Energy Technology Data Exchange (ETDEWEB)

    Lefevre, Mireille; Gschwind, Benoit; Blanc, Isabelle; Ranchin, Thierry [MINES ParisTech, Sophia Antipolis (France). Observation, Impacts, Energy Center; Wyrwa, Artur; Drebszok, Kamila [AGH Univ. of Science and Technology, Krakow (Poland); Cofala, Janusz; Fuss, Sabine [International Institute for Applied Systems Analysis (IIASA), Laxenburg (Austria)

    2013-07-01

    This article reports impact results from running the EnerGEO Platform of Integrated Assessment (PIA) related to human health for different scenarios in Europe. The scenarios were prepared within the EnerGEO project. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable energy, affect concentrations of air pollutants and as a consequence affect human health. PM{sub 2.5} concentrations were estimated with the IIASA Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model on a time horizon up to the year 2050 for different scenarios. We analyse here the estimation of the Loss of Life Expectancy due to PM{sub 2.5} concentrations for the Baseline scenario taken as a reference and the Maximum renewable power scenario. (orig.)

  3. An integrated platform for large-scale data collection and precise perturbation of live Drosophila embryos

    Science.gov (United States)

    Levario, Thomas J.; Zhao, Charles; Rouse, Tel; Shvartsman, Stanislav Y.; Lu, Hang

    2016-02-01

    Understanding the fundamental principles governing embryogenesis is a key goal of developmental biology. Direct observation of embryogenesis via in vivo live imaging is vital to understanding embryogenesis; yet, tedious sample preparation makes it difficult to acquire large-scale imaging data that is often required to overcome experimental and biological noises for quantitative studies. Furthermore, it is often difficult, and sometimes impossible, to incorporate environmental perturbation for understanding developmental responses to external stimuli. To address this issue, we have developed a method for high-throughput imaging of live embryos, delivering precise environmental perturbations, and unbiased data extraction. This platform includes an optimized microfluidic device specifically for live embryos and also for precise perturbations in the microenvironment of the developing embryos. In addition, we developed software for simple, yet accurate, automated segmentation of fluorescent images, and automated data extraction. Using a quantitative assessment we find that embryos develop normally within the microfluidic device. Finally, we show an application of the high-throughput assay for monitoring developmental responses to external stimuli: anoxia-induced developmental arrest in Drosophila embryos. With slight modifications, the method developed in this work can be applied to many other models of development and other stimulus-response behaviors during development.

  4. The development of an integrated platform to identify breast cancer glycoproteome changes in human serum.

    Science.gov (United States)

    Zeng, Zhi; Hincapie, Marina; Haab, Brian B; Hanash, Samir; Pitteri, Sharon J; Kluck, Steven; Hogan, Jason M; Kennedy, Jacob; Hancock, William S

    2010-05-07

    Protein glycosylation represents one of the major post-translational modifications and can have significant effects on protein function. Moreover, changes in the carbohydrate structure are increasingly being recognized as an important modification associated with cancer etiology. In this report, we describe the development of a proteomics approach to identify breast cancer related changes in either concentration and/or the carbohydrate structures of glycoprotein(s) present in blood samples. Diseased and healthy serum samples were processed by an optimized sample preparation protocol using multiple lectin affinity chromatography (M-LAC) that partitions serum proteins based on glycan characteristics. Subsequently, three separate procedures, 1D SDS-PAGE, isoelectric focusing and an antibody microarray, were applied to identify potential candidate markers for future study. The combination of these three platforms is illustrated in this report with the analysis of control and cancer glycoproteomic fractions. Firstly, a molecular weight based separation of glycoproteins by 1D SDS-PAGE was performed, followed by protein, glycoprotein staining, lectin blotting and LC-MS analysis. To refine or confirm the list of interesting glycoproteins, isoelectric focusing (targeting sialic acid changes) and an antibody microarray (used to detect neutral glycan shifts) were selected as the orthogonal methods. As a result, several glycoproteins including alpha-1B-glycoprotein, complement C3, alpha-1-antitrypsin and transferrin were identified as potential candidates for further study.

  5. Integrated microfluidics platforms for investigating injury and regeneration of CNS axons.

    Science.gov (United States)

    Kim, Hyung Joon; Park, Jeong Won; Byun, Jae Hwan; Vahidi, Behrad; Rhee, Seog Woo; Jeon, Noo Li

    2012-06-01

    We describe the development of experimental platforms to quantify the regeneration of injured central nervous system (CNS) neurons by combining engineering technologies and primary neuronal cultures. Although the regeneration of CNS neurons is an important area of research, there are no currently available methods to screen for drugs. Conventional tissue culture based on Petri dish does not provide controlled microenvironment for the neurons and only provide qualitative information. In this review, we introduced the recent advances to generate in vitro model system that is capable of mimicking the niche of CNS injury and regeneration and also of testing candidate drugs. We reconstructed the microenvironment of the regeneration of CNS neurons after injury to provide as in vivo like model system where the soluble and surface bounded inhibitors for regeneration are presented in physiologically relevant manner using microfluidics and surface patterning methods. The ability to control factors and also to monitor them using live cell imaging allowed us to develop quantitative assays that can be used to compare various drug candidates and also to understand the basic mechanism behind nerve regeneration after injury.

  6. SIM-DSP: A DSP-Enhanced CAD Platform for Signal Integrity Macromodeling and Simulation

    Directory of Open Access Journals (Sweden)

    Chi-Un Lei

    2014-12-01

    Full Text Available Macromodeling-Simulation process for signal integrity verifications has become necessary for the high speed circuit system design. This paper aims to introduce a “VLSI Signal Integrity Macromodeling and Simulation via Digital Signal Processing Techniques” framework (known as SIM-DSP framework, which applies digital signal processing techniques to facilitate the SI verification process in the pre-layout design phase. Core identification modules and peripheral (pre-/post-processing modules have been developed and assembled to form a verification flow. In particular, a single-step discrete cosine transform truncation (DCTT module has been developed for modeling-simulation process. In DCTT, the response modeling problem is classified as a signal compression problem, wherein the system response can be represented by a truncated set of non-pole based DCT bases, and error can be analyzed through Parseval’s theorem. Practical examples are given to show the applicability of our proposed framework.

  7. Simulation platform for application development on a vision-system-on-chip with integrated signal processing

    Science.gov (United States)

    Reichel, Peter; Döge, Jens; Hoppe, Christoph; Peter, Nico; Reichel, Andreas; Schneider, Peter

    2016-07-01

    Image sensors with integrated, programmable signal processing execute computationally intensive processing steps during or immediately after image acquisition, thereby allowing for reducing output data to relevant features only. In contrast to conventional image processing systems, the tasks of image acquisition and actual image processing in such a "vision chip" cannot be viewed independently of each other. Both for validating the architecture and supporting programming in the course of application development, modeling on the system level has been performed as part of the design process of the vision-system-on-chip. Apart from the implementation of all essential components of the integrated control unit as well as digital and analog signal processing, special attention has been paid to the integration into the development environment. Being able to purposefully insert parameter deviations and/or defects at different points of the analog processing enables investigations with respect to their influence on image processing algorithms performed on the image sensor. Due to its high simulation speed and compatibility to the real system, especially regarding the to-be-executed programs, the resulting simulation model is very well suited for use in application development.

  8. The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

    Science.gov (United States)

    Mungall, Christopher J.; McMurry, Julie A.; Köhler, Sebastian; Balhoff, James P.; Borromeo, Charles; Brush, Matthew; Carbon, Seth; Conlin, Tom; Dunn, Nathan; Engelstad, Mark; Foster, Erin; Gourdine, J.P.; Jacobsen, Julius O.B.; Keith, Dan; Laraway, Bryan; Lewis, Suzanna E.; NguyenXuan, Jeremy; Shefchek, Kent; Vasilevsky, Nicole; Yuan, Zhou; Washington, Nicole; Hochheiser, Harry; Groza, Tudor; Smedley, Damian; Robinson, Peter N.; Haendel, Melissa A.

    2017-01-01

    The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype–phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms. Advanced informatics tools can identify phenotypically relevant disease models in research and diagnostic contexts. Large-scale integration of model organism and clinical research data can provide a breadth of knowledge not available from individual sources and can provide contextualization of data back to these sources. The Monarch Initiative (monarchinitiative.org) is a collaborative, open science effort that aims to semantically integrate genotype–phenotype data from many species and sources in order to support precision medicine, disease modeling, and mechanistic exploration. Our integrated knowledge graph, analytic tools, and web services enable diverse users to explore relationships between phenotypes and genotypes across species. PMID:27899636

  9. The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species.

    Science.gov (United States)

    Mungall, Christopher J; McMurry, Julie A; Köhler, Sebastian; Balhoff, James P; Borromeo, Charles; Brush, Matthew; Carbon, Seth; Conlin, Tom; Dunn, Nathan; Engelstad, Mark; Foster, Erin; Gourdine, J P; Jacobsen, Julius O B; Keith, Dan; Laraway, Bryan; Lewis, Suzanna E; NguyenXuan, Jeremy; Shefchek, Kent; Vasilevsky, Nicole; Yuan, Zhou; Washington, Nicole; Hochheiser, Harry; Groza, Tudor; Smedley, Damian; Robinson, Peter N; Haendel, Melissa A

    2017-01-04

    The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype-phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms. Advanced informatics tools can identify phenotypically relevant disease models in research and diagnostic contexts. Large-scale integration of model organism and clinical research data can provide a breadth of knowledge not available from individual sources and can provide contextualization of data back to these sources. The Monarch Initiative (monarchinitiative.org) is a collaborative, open science effort that aims to semantically integrate genotype-phenotype data from many species and sources in order to support precision medicine, disease modeling, and mechanistic exploration. Our integrated knowledge graph, analytic tools, and web services enable diverse users to explore relationships between phenotypes and genotypes across species.

  10. Two-dimensional hydrodynamic flow focusing in a microfluidic platform featuring a monolithic integrated glass micronozzle

    Science.gov (United States)

    Liu, Yifan; Shen, Yusheng; Duan, Lian; Yobas, Levent

    2016-10-01

    Two-dimensional hydrodynamic flow focusing is demonstrated through a microfluidic device featuring a monolithic integrated glass micronozzle inside a flow-focusing geometry. Such a coaxial configuration allows simple one-step focusing of a sample fluid stream, jetted from the micronozzle tip, in both in-plane and out-of-plane directions. The width of the focused filament can be precisely controlled and further scaled down to the submicrometer regime to facilitate rapid hydrodynamic mixing. Fluorescence quenching experiments reveal ultra-fast microsecond mixing of the denaturant into the focused filament. This device offers new possibilities to a set of applications such as the study of protein folding kinetics.

  11. Integrated programmable photonic filter on the silicon-on-insulator platform.

    Science.gov (United States)

    Liao, Shasha; Ding, Yunhong; Peucheret, Christophe; Yang, Ting; Dong, Jianji; Zhang, Xinliang

    2014-12-29

    We propose and demonstrate a silicon-on-insulator (SOI) on-chip programmable filter based on a four-tap finite impulse response structure. The photonic filter is programmable thanks to amplitude and phase modulation of each tap controlled by thermal heaters. We further demonstrate the tunability of the filter central wavelength, bandwidth and variable passband shape. The tuning range of the central wavelength is at least 42% of the free spectral range. The bandwidth tuning range is at least half of the free spectral range. Our scheme has distinct advantages of compactness, capability for integrating with electronics.

  12. Saccharomyces cerevisiae–Based Platform for Rapid Production and Evaluation of Eukaryotic Nutrient Transporters and Transceptors for Biochemical Studies and Crystallography

    DEFF Research Database (Denmark)

    Scharff-Poulsen, Peter; Pedersen, Per Amstrup

    2013-01-01

    localization, quantification, quality control, and purification. Using this expression system we examined the production of a human glucose transceptor and 11 nutrient transporters and transceptors from S. cerevisiae that have not previously been overexpressed in S. cerevisiae and purified. Whole...... transporter pr. liter cell culture. A detergent screen showed that n-dodecyl-ß-D-maltopyranoside (DDM) is acceptable for solubilization of the membrane-integrated fusions. Extracts of solubilized membranes were prepared with this detergent and used for purifications by Ni-NTA affinity chromatography, which...... yielded partially purified full-length fusions. Most of the fusions were readily cleaved at a TEV protease site between the membrane protein and the GFP-8His tag. Using the yeast oligopeptide transporter Ptr2 as an example, we further demonstrate that almost pure transporters, free of the GFP-8His tag...

  13. Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.

    Science.gov (United States)

    Chopda, Viki R; Gomes, James; Rathore, Anurag S

    2016-01-01

    Bioreactor control significantly impacts both the amount and quality of the product being manufactured. The complexity of the control strategy that is implemented increases with reactor size, which may vary from thousands to tens of thousands of litres in commercial manufacturing. The Process Analytical Technology (PAT) initiative has highlighted the need for having robust monitoring tools and effective control schemes that are capable of taking real time information about the critical quality attributes (CQA) and the critical process parameters (CPP) and executing immediate response as soon as a deviation occurs. However, the limited flexibility that present commercial software packages offer creates a hurdle. Visual programming environments have gradually emerged as potential alternatives to the available text based languages. This paper showcases development of an integrated programme using a visual programming environment for a Sartorius BIOSTAT® B Plus 5L bioreactor through which various peripheral devices are interfaced. The proposed programme facilitates real-time access to data and allows for execution of control actions to follow the desired trajectory. Major benefits of such integrated software system include: (i) improved real time monitoring and control; (ii) reduced variability; (iii) improved performance; (iv) reduced operator-training time; (v) enhanced knowledge management; and (vi) easier PAT implementation.

  14. Functional integrity of flexible n-channel metal–oxide–semiconductor field-effect transistors on a reversibly bistable platform

    KAUST Repository

    Alfaraj, Nasir

    2015-10-26

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal–oxide–semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  15. Functional integrity of flexible n-channel metal-oxide-semiconductor field-effect transistors on a reversibly bistable platform

    Science.gov (United States)

    Alfaraj, Nasir; Hussain, Aftab M.; Torres Sevilla, Galo A.; Ghoneim, Mohamed T.; Rojas, Jhonathan P.; Aljedaani, Abdulrahman B.; Hussain, Muhammad M.

    2015-10-01

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal-oxide-semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  16. Integrated reconfigurable multiple-input–multiple-output antenna system with an ultra-wideband sensing antenna for cognitive radio platforms

    KAUST Repository

    Hussain, Rifaqat

    2015-06-18

    © The Institution of Engineering and Technology 2015. A compact, novel multi-mode, multi-band frequency reconfigurable multiple-input-multiple-output (MIMO) antenna system, integrated with ultra-wideband (UWB) sensing antenna, is presented. The developed model can be used as a complete antenna platform for cognitive radio applications. The antenna system is developed on a single substrate area of dimensions 65 × 120 mm2. The proposed sensing antenna is used to cover a wide range of frequency bands from 710 to 3600 MHz. The frequency reconfigurable dual-element MIMO antenna is integrated with P-type, intrinsic, N-type (PIN) diodes for frequency agility. Different modes of selection are used for the MIMO antenna system reconfigurability to support different wireless system standards. The proposed MIMO antenna configuration is used to cover various frequency bands from 755 to 3450 MHz. The complete system comprising the multi-band reconfigurable MIMO antennas and UWB sensing antenna for cognitive radio applications is proposed with a compact form factor.

  17. Discussion on Manufacturing and Services Integration Based on E-Commerce Platform

    Directory of Open Access Journals (Sweden)

    Li Jinfa

    2017-01-01

    Full Text Available The integration of manufacturing and services is the key to adapt to the inevitable requirement of the revolution of the development of a new round of mobile Internet industry. They are also the key and trend of the next period to enhance the quality and efficiency of Chinese’s manufacturing industry to release potential services development fully, and cultivate new economic growth point.Meanwhile it makes it more effective than before.The enterprises can publicize their own values as well as collect and deal with consumer feedback of the product experience more effectively.And then,it can grasp the market trends and adapt to developping world more quickly.

  18. DNA - An integrated open-source optimization platform for thermo-fluid systems

    DEFF Research Database (Denmark)

    Pierobon, Leonardo; Wronski, Jorrit; Elmegaard, Brian

    2014-01-01

    dynamic and steady-state energy systems and is now available for the most common operating systems (Windows, Mac OS and Linux). Emerging interest in novel plant technologies, high-temperature heat pumps, refrigeration absorption modules, and in energy system optimization has stressed the necessity...... 110 fluids by interfacing CoolProp, a high-accuracy open-source property package for pure and pseudo-pure fluids, as well as humid air. Furthermore, the use as time integrator for other tools is demonstrated. The new features are unveiled in two case studies. The first example covers the optimization...... of an air bottoming cycle unit recuperating the exhaust heat from an offshore power system. Subsequently, the control of a compressed air energy storage plant is modelled by interfacing with Matlab. Both cases take advantage of CoolProp’s table-based property interpolation scheme...

  19. SYSTEM FOR TORQUE CONVERTER DESIGN AND ANALYSIS BASED ON CAD/CFD INTEGRATED PLATFORM

    Institute of Scientific and Technical Information of China (English)

    WU Guangqiang; YAN Peng

    2008-01-01

    A 3D torque converter design system is developed based on numerical investigation into flow field and CAD technology. The 3D steady-state flow field simulation is undertaken by using time averaged Reynolds equation and k-epsilon turbulence model, with mixing-plane boundary conditions at three section interfaces. The blades are designed according to the flow field characteristics by using a reverse design method in the system. The accurateness of numerical analysis and the validity of design system are verified by the fluid field experiment of desingn example of the torque converter. This kind of design and analysis system for torque converter based on integration of comput ationol fluid dynamics (CFD) and CAD is a powerful tool for torque converter manufacturing, but also a prettg important significance for research and development.

  20. Research and Design on Information Service and Management Platform based on Work Integrated Learning Mode

    Directory of Open Access Journals (Sweden)

    Gao Qi Yuan

    2016-01-01

    Full Text Available The work integrated learning mode is the world’s more advanced kind of teaching mode, which in many countries have achieved success, but also the rapid development in China. This paper is conscientiously sum of basic school vocational college engineering student management, aimed at the exchange of services and management schools as well as schools, businesses, students communicate among emerging issues were discussed ,proposed information technology services and management, consciously to promote student learning through the application, to improve learning efficiency, can strong the service awareness of schools, businesses for the students , promote school students and the school’s teaching, management form a whole, to facilitate the strengthening of students management and strengthen the contact of schools, businesses, students.

  1. A purge and trap integrated microGC platform for chemical identification in aqueous samples.

    Science.gov (United States)

    Akbar, Muhammad; Narayanan, Shree; Restaino, Michael; Agah, Masoud

    2014-07-07

    The majority of current micro-scale gas chromatography (μGC) systems focus on air sampling to detect volatile organic compounds (VOCs). However, purging the VOCs from a water sample using microsystems is an unchartered territory. Various organic compounds used in everyday life find their way to water bodies. Some of these water organic compounds (WOCs) persist or degrade slowly, threatening not just human existence but also aquatic life. This article reports the first micro-purge extractor (μPE) chip and its integration with a micro-scale gas chromatography (μGC) system for the extraction and analysis of water organic compounds (WOCs) from aqueous samples. The 2 cm × 3 cm μPE chip contains two inlet and outlet ports and an etched cavity sealed with a Pyrex cover. The aqueous sample is introduced from the top inlet port while a pure inert gas is supplied from the side inlet to purge WOCs from the μPE chip. The outlets are assigned for draining water from the chip and for directing purged WOCs to the micro-thermal preconcentrator (μTPC). The trapped compounds are desorbed from the μTPC by resistive heating using the on-chip heater and temperature sensor, are separated by a 2 m long, 80 μm wide, and 250 μm deep polydimethylsiloxane (OV-1) coated μGC separation column, and are identified using a micro-thermal conductivity detector (μTCD) monolithically integrated with the column. Our experiments indicate that the combined system is capable of providing rapid chromatographic separation (<1.5 min) for quaternary WOCs namely toluene, tetrachloroethylene (PCE), chlorobenzene and ethylbenzene with a minimum detection concentration of 500 parts-per-billion (ppb) in aqueous samples. The proposed method is a promising development towards the future realization of a miniaturized system for sensitive, on-site and real-time field analysis of organic contaminants in water.

  2. T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Sriram S

    2008-07-01

    Full Text Available Abstract Background Type 2 Diabetes Mellitus (T2DM is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors. The advanced stage in type 2 diabetes mellitus leads to several micro and macro vascular complications like nephropathy, neuropathy, retinopathy, heart related problems etc. Studies performed on the genetics, biochemistry and molecular biology of this disease to understand the pathophysiology of type 2 diabetes mellitus has led to the generation of a surfeit of data on candidate genes and related aspects. The research is highly progressive towards defining the exact etiology of this disease. Results T2D-Db (Type 2 diabetes Database is a comprehensive web resource, which provides integrated and curated information on almost all known molecular components involved in the pathogenesis of type 2 diabetes mellitus in the three widely studied mammals namely human, mouse and rat. Information on candidate genes, SNPs (Single Nucleotide Polymorphism in candidate genes or candidate regions, genome wide association studies (GWA, tissue specific gene expression patterns, EST (Expressed Sequence Tag data, expression information from microarray data, pathways, protein-protein interactions and disease associated risk factors or complications have been structured in this on line resource. Conclusion Information available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. Importantly, the resource facilitates graphical presentation of the gene/genome wide map of SNP markers and protein-protein interaction networks, besides providing the heat map diagram of the selected gene(s in an organism across microarray expression experiments from either single or multiple studies. These features aid to the data interpretation in an integrative way. T2D-Db is to our knowledge the first publicly available resource that

  3. Event-triggered logical flow control for comprehensive process integration of multi-step assays on centrifugal microfluidic platforms.

    Science.gov (United States)

    Kinahan, David J; Kearney, Sinéad M; Dimov, Nikolay; Glynn, Macdara T; Ducrée, Jens

    2014-07-01

    The centrifugal "lab-on-a-disc" concept has proven to have great potential for process integration of bioanalytical assays, in particular where ease-of-use, ruggedness, portability, fast turn-around time and cost efficiency are of paramount importance. Yet, as all liquids residing on the disc are exposed to the same centrifugal field, an inherent challenge of these systems remains the automation of multi-step, multi-liquid sample processing and subsequent detection. In order to orchestrate the underlying bioanalytical protocols, an ample palette of rotationally and externally actuated valving schemes has been developed. While excelling with the level of flow control, externally actuated valves require interaction with peripheral instrumentation, thus compromising the conceptual simplicity of the centrifugal platform. In turn, for rotationally controlled schemes, such as common capillary burst valves, typical manufacturing tolerances tend to limit the number of consecutive laboratory unit operations (LUOs) that can be automated on a single disc. In this paper, a major advancement on recently established dissolvable film (DF) valving is presented; for the very first time, a liquid handling sequence can be controlled in response to completion of preceding liquid transfer event, i.e. completely independent of external stimulus or changes in speed of disc rotation. The basic, event-triggered valve configuration is further adapted to leverage conditional, large-scale process integration. First, we demonstrate a fluidic network on a disc encompassing 10 discrete valving steps including logical relationships such as an AND-conditional as well as serial and parallel flow control. Then we present a disc which is capable of implementing common laboratory unit operations such as metering and selective routing of flows. Finally, as a pilot study, these functions are integrated on a single disc to automate a common, multi-step lab protocol for the extraction of total RNA from

  4. Development of an Integrated Process, Modeling and Simulation Platform for Performance-Based Design of Low-Energy and High IEQ Buildings

    Science.gov (United States)

    Chen, Yixing

    2013-01-01

    The objective of this study was to develop a "Virtual Design Studio (VDS)": a software platform for integrated, coordinated and optimized design of green building systems with low energy consumption, high indoor environmental quality (IEQ), and high level of sustainability. The VDS is intended to assist collaborating architects,…

  5. Human Disease Insight: An integrated knowledge-based platform for disease-gene-drug information.

    Science.gov (United States)

    Tasleem, Munazzah; Ishrat, Romana; Islam, Asimul; Ahmad, Faizan; Hassan, Md Imtaiyaz

    2016-01-01

    The scope of the Human Disease Insight (HDI) database is not limited to researchers or physicians as it also provides basic information to non-professionals and creates disease awareness, thereby reducing the chances of patient suffering due to ignorance. HDI is a knowledge-based resource providing information on human diseases to both scientists and the general public. Here, our mission is to provide a comprehensive human disease database containing most of the available useful information, with extensive cross-referencing. HDI is a knowledge management system that acts as a central hub to access information about human diseases and associated drugs and genes. In addition, HDI contains well-classified bioinformatics tools with helpful descriptions. These integrated bioinformatics tools enable researchers to annotate disease-specific genes and perform protein analysis, search for biomarkers and identify potential vaccine candidates. Eventually, these tools will facilitate the analysis of disease-associated data. The HDI provides two types of search capabilities and includes provisions for downloading, uploading and searching disease/gene/drug-related information. The logistical design of the HDI allows for regular updating. The database is designed to work best with Mozilla Firefox and Google Chrome and is freely accessible at http://humandiseaseinsight.com.

  6. REAL TIME INTEGRATION OF FIELD DATA INTO A GIS PLATFORM FOR THE MANAGEMENT OF HYDROLOGICAL EMERGENCIES

    Directory of Open Access Journals (Sweden)

    M. Mangiameli

    2014-01-01

    Full Text Available A wide series of events requires immediate availability of information and field data to be provided to decision-makers. An example is the necessity of quickly transferring the information acquired from monitoring and alerting sensors or the data of the reconnaissance of damage after a disastrous event to an Emergency Operations Center. To this purpose, we developed an integrated GIS and WebGIS system to dynamically create and populate via Web a database with spatial features. In particular, this work concerns the gathering and transmission of spatial data and related information to the desktop GIS so that they can be displayed and analyzed in real time to characterize the operational scenario and to decide the rescue interventions. As basic software, we used only free and open source: QuantumGIS and Grass as Desktop GIS, Map Server with PMapper application for the Web-Gis functionality and PostGreSQL/PostGIS as Data Base Management System (DBMS. The approach has been designed, developed and successfully tested in the management of GIS-based navigation of an autonomous robot, both to map its trajectories and to assign optimal paths. This paper presents the application of our system to a simulated hydrological event that could interest the province of Catania, in Sicily. In particular, assuming that more teams draw up an inventory of the damage, we highlight the benefits of real-time transmission of the information collected from the field to headquarters.

  7. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform.

    Science.gov (United States)

    Tandon, Vishal; Kang, Woo Seok; Spencer, Abigail J; Kim, Ernest S; Pararas, Erin E L; McKenna, Michael J; Kujawa, Sharon G; Mescher, Mark J; Fiering, Jason; Sewell, William F; Borenstein, Jeffrey T

    2015-04-01

    One of the major challenges in treatment of auditory disorders is that many therapeutic compounds are toxic when delivered systemically. Local intracochlear delivery methods are becoming critical in emerging treatments and in drug discovery. Direct infusion via cochleostomy, in particular, is attractive from a pharmacokinetics standpoint, as there is potential for the kinetics of delivery to be well-controlled. Direct infusion is compatible with a large number of drug types, including large, complex molecules such as proteins and unstable molecules such as siRNA. In addition, hair-cell regeneration therapy will likely require long-term delivery of a timed series of agents. This presents unknown risks associated with increasing the volume of fluid within the cochlea and mechanical damage caused during delivery. There are three key requirements for an intracochlear drug delivery system: (1) a high degree of miniaturization (2) a method for pumping precise and small volumes of fluid into the cochlea in a highly controlled manner, and (3) a method for removing excess fluid from the limited cochlear fluid space. To that end, our group is developing a head-mounted microfluidics-based system for long-term intracochlear drug delivery. We utilize guinea pig animal models for development and demonstration of the device. Central to the system is an infuse-withdraw micropump component that, unlike previous micropump-based systems, has fully integrated drug and fluid storage compartments. Here we characterize the infuse-withdraw capabilities of our micropump, and show experimental results that demonstrate direct drug infusion via cochleostomy in animal models. We utilized DNQX, a glutamate receptor antagonist that suppresses CAPs, as a test drug. We monitored the frequency-dependent changes in auditory nerve CAPs during drug infusion, and observed CAP suppression consistent with the expected drug transport path based on the geometry and tonotopic organization of the cochlea.

  8. Integration of the TNXYZ computer program inside the platform Salome; Integracion del programa de computo TNXYZ dentro de la plataforma Salome

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.

    2014-07-01

    The present work shows the procedure carried out to integrate the code TNXYZ as a calculation tool at the graphical simulation platform Salome. The TNXYZ code propose a numerical solution of the neutron transport equation, in several groups of energy, steady-state and three-dimensional geometry. In order to discretized the variables of the transport equation, the code uses the method of discrete ordinates for the angular variable, and a nodal method for the spatial dependence. The Salome platform is a graphical environment designed for building, editing and simulating mechanical models mainly focused on the industry and unlike other software, in order to form a complete scheme of pre and post processing of information, to integrate and control an external source code. Before the integration the in the Salome platform TNXYZ code was upgraded. TNXYZ was programmed in the 90s using Fortran 77 compiler; for this reason the code was adapted to the characteristics of the current Fortran compilers; in addition, with the intention of extracting partial results over the process sequence, the original structure of the program underwent a modularization process, i.e. the main program was divided into sections where the code performs major operations. This procedure is controlled by the information module (YACS) on Salome platform, and it could be useful for a subsequent coupling with thermal-hydraulics codes. Finally, with the help of the Monte Carlo code Serpent several study cases were defined in order to check the process of integration; the verification process consisted in performing a comparison of the results obtained with the code executed as stand-alone and after modernized, integrated and controlled by the Salome platform. (Author)

  9. MALDI-TOF-MS Platform for Integrated Proteomic and Peptidomic Profiling of Milk Samples Allows Rapid Detection of Food Adulterations.

    Science.gov (United States)

    Sassi, Mauro; Arena, Simona; Scaloni, Andrea

    2015-07-15

    Adulteration of ovine, caprine, and buffalo milks with more common bovine material occurs for economic reasons and seasonal availability. Frauds are also associated with the use of powdered milk instead of declared, fresh material. In this context, various analytical methods have been adapted to dairy science applications with the aim to evaluate adulteration of milk samples, although time-consuming, suitable only for speciation or thermal treatment analysis, or useful for a specific fraud type. An integrated MALDI-TOF-MS platform for the combined peptidomic and proteomic profiling of milk samples is here presented, which allows rapid detection of illegal adulterations due to the addition of either nondeclared bovine material to water buffalo, goat, and ovine milks or of powdered bovine milk to the fresh counterpart. Peptide and protein markers of each animal milk were identified after direct analysis of a large number of diluted skimmed and/or enriched diluted skimmed filtrate samples. In parallel, markers of thermal treatment were characterized in different types of commercial milks. Principal components scores of ad hoc prepared species- or thermal treatment-associated adulterated milk samples were subjected to partial least-squares regression, permitting a fast accurate estimate of the fraud extents in test samples at either protein and peptide level. With respect to previous reports on MALDI-TOF-MS protein profiling methodologies for milk speciation, this study extends that approach to the analysis of the thermal treatment and introduces an independent, complementary peptide profiling measurement, which integrates protein data with additional information on peptides, validating final results and ultimately broadening the method applicability.

  10. An integrated platform enabling optogenetic illumination of Caenorhabditis elegans neurons and muscular force measurement in microstructured environments.

    Science.gov (United States)

    Qiu, Zhichang; Tu, Long; Huang, Liang; Zhu, Taoyuanmin; Nock, Volker; Yu, Enchao; Liu, Xiao; Wang, Wenhui

    2015-01-01

    Optogenetics has been recently applied to manipulate the neural circuits of Caenorhabditis elegans (C. elegans) to investigate its mechanosensation and locomotive behavior, which is a fundamental topic in model biology. In most neuron-related research, free C. elegans moves on an open area such as agar surface. However, this simple environment is different from the soil, in which C. elegans naturally dwells. To bridge up the gap, this paper presents integration of optogenetic illumination of C. elegans neural circuits and muscular force measurement in a structured microfluidic chip mimicking the C. elegans soil habitat. The microfluidic chip is essentially a ∼1 × 1 cm(2) elastomeric polydimethylsiloxane micro-pillar array, configured in either form of lattice (LC) or honeycomb (HC) to mimic the environment in which the worm dwells. The integrated system has four key modules for illumination pattern generation, pattern projection, automatic tracking of the worm, and force measurement. Specifically, two optical pathways co-exist in an inverted microscope, including built-in bright-field illumination for worm tracking and pattern generation, and added-in optogenetic illumination for pattern projection onto the worm body segment. The behavior of a freely moving worm in the chip under optogenetic manipulation can be recorded for off-line force measurements. Using wild-type N2 C. elegans, we demonstrated optical illumination of C. elegans neurons by projecting light onto its head/tail segment at 14 Hz refresh frequency. We also measured the force and observed three representative locomotion patterns of forward movement, reversal, and omega turn for LC and HC configurations. Being capable of stimulating or inhibiting worm neurons and simultaneously measuring the thrust force, this enabling platform would offer new insights into the correlation between neurons and locomotive behaviors of the nematode under a complex environment.

  11. ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings.

    Science.gov (United States)

    Pelletier, D; Wiegers, T C; Enayetallah, A; Kibbey, C; Gosink, M; Koza-Taylor, P; Mattingly, C J; Lawton, M

    2016-01-01

    Attempts are frequently made to investigate adverse findings from preclinical toxicology studies in order to better understand underlying toxicity mechanisms. These efforts often begin with limited information, including a description of the adverse finding, knowledge of the structure of the chemical associated with its cause and the intended pharmacological target. ToxEvaluator was developed jointly by Pfizer and the Comparative Toxicogenomics Database (http://ctdbase.org) team at North Carolina State University as an in silico platform to facilitate interpretation of toxicity findings in light of prior knowledge. Through the integration of a diverse set of in silico tools that leverage a number of public and proprietary databases, ToxEvaluator streamlines the process of aggregating and interrogating diverse sources of information. The user enters compound and target identifiers, and selects adverse event descriptors from a safety lexicon and mapped MeSH disease terms. ToxEvaluator provides a summary report with multiple distinct areas organized according to what target or structural aspects have been linked to the adverse finding, including primary pharmacology, structurally similar proprietary compounds, structurally similar public domain compounds, predicted secondary (i.e. off-target) pharmacology and known secondary pharmacology. Similar proprietary compounds and their associated in vivo toxicity findings are reported, along with a link to relevant supporting documents. For similar public domain compounds and interacting targets, ToxEvaluator integrates relationships curated in Comparative Toxicogenomics Database, returning all direct and inferred linkages between them. As an example of its utility, we demonstrate how ToxEvaluator rapidly identified direct (primary pharmacology) and indirect (secondary pharmacology) linkages between cerivastatin and myopathy.

  12. The Qatar National Historic Environment Record: a Platform for the Development of a Fully-Integrated Cultural Heritage Management Application

    Science.gov (United States)

    Cuttler, R. T. H.; Tonner, T. W. W.; Al-Naimi, F. A.; Dingwall, L. M.; Al-Hemaidi, N.

    2013-07-01

    The development of the Qatar National Historic Environment Record (QNHER) by the Qatar Museums Authority and the University of Birmingham in 2008 was based on a customised, bilingual Access database and ArcGIS. While both platforms are stable and well supported, neither was designed for the documentation and retrieval of cultural heritage data. As a result it was decided to develop a custom application using Open Source code. The core module of this application is now completed and is orientated towards the storage and retrieval of geospatial heritage data for the curation of heritage assets. Based on MIDAS Heritage data standards and regionally relevant thesauri, it is a truly bilingual system. Significant attention has been paid to the user interface, which is userfriendly and intuitive. Based on a suite of web services and accessed through a web browser, the system makes full use of internet resources such as Google Maps and Bing Maps. The application avoids long term vendor ''tie-ins'' and as a fully integrated data management system, is now an important tool for both cultural resource managers and heritage researchers in Qatar.

  13. Laser-induced heating integrated with a microfluidic platform for real-time DNA replication and detection

    Science.gov (United States)

    Hung, Min-Sheng; Ho, Chia-Chin; Chen, Chih-Pin

    2016-08-01

    This study developed a microfluidic platform for replicating and detecting DNA in real time by integrating a laser and a microfluidic device composed of polydimethylsiloxane. The design of the microchannels consisted of a laser-heating area and a detection area. An infrared laser was used as the heating source for DNA replication, and the laser power was adjusted to heat the solutions directly. In addition, strong biotin-avidin binding was used to capture and detect the replicated products. The biotin on one end was bound to avidin and anchored to the surface of the microchannels, whereas the biotin on the other end was bound to the quantum dots (Qdots). The results showed that the fluorescent intensity of the Qdots bound to the replicated products in the detection area increased with the number of thermal cycles created by the laser. When the number of thermal cycles was ≥10, the fluorescent intensity of the Qdots was directly detectable on the surface of the microchannels. The proposed method is more sensitive than detection methods entailing gel electrophoresis.

  14. PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.

    Science.gov (United States)

    Chang, Fiona T M; McGhie, James D; Chan, F Lyn; Tang, Michelle C; Anderson, Melissa A; Mann, Jeffrey R; Andy Choo, K H; Wong, Lee H

    2013-04-01

    We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric chromatin in mouse embryonic stem cells. The function of ATRX and H3.3 in the maintenance of telomere chromatin integrity is further demonstrated by recent studies that show the strong association of ATRX/H3.3 mutations with alternative lengthening of telomeres in telomerase-negative human cancer cells. Here, we demonstrate that ATRX and H3.3 co-localize with the telomeric DNA and associated proteins within the promyelocytic leukemia (PML) bodies in mouse ES cells. The assembly of these telomere-associated PML bodies is most prominent at S phase. RNA interference (RNAi)-mediated knockdown of PML expression induces the disassembly of these nuclear bodies and a telomere dysfunction phenotype in mouse ES cells. Loss of function of PML bodies in mouse ES cells also disrupts binding of ATRX/H3.3 and proper establishment of histone methylation pattern at the telomere. Our study demonstrates that PML bodies act as epigenetic regulators by serving as platforms for the assembly of the telomeric chromatin to ensure a faithful inheritance of epigenetic information at the telomere.

  15. Independent Evaluation of the integrated Community Case Management of Childhood Illness Strategy in Malawi Using a National Evaluation Platform Design.

    Science.gov (United States)

    Amouzou, Agbessi; Kanyuka, Mercy; Hazel, Elizabeth; Heidkamp, Rebecca; Marsh, Andrew; Mleme, Tiope; Munthali, Spy; Park, Lois; Banda, Benjamin; Moulton, Lawrence H; Black, Robert E; Hill, Kenneth; Perin, Jamie; Victora, Cesar G; Bryce, Jennifer

    2016-03-01

    We evaluated the impact of integrated community case management of childhood illness (iCCM) on careseeking for childhood illness and child mortality in Malawi, using a National Evaluation Platform dose-response design with 27 districts as units of analysis. "Dose" variables included density of iCCM providers, drug availability, and supervision, measured through a cross-sectional cellular telephone survey of all iCCM-trained providers. "Response" variables were changes between 2010 and 2014 in careseeking and mortality in children aged 2-59 months, measured through household surveys. iCCM implementation strength was not associated with changes in careseeking or mortality. There were fewer than one iCCM-ready provider per 1,000 under-five children per district. About 70% of sick children were taken outside the home for care in both 2010 and 2014. Careseeking from iCCM providers increased over time from about 2% to 10%; careseeking from other providers fell by a similar amount. Likely contributors to the failure to find impact include low density of iCCM providers, geographic targeting of iCCM to "hard-to-reach" areas although women did not identify distance from a provider as a barrier to health care, and displacement of facility careseeking by iCCM careseeking. This suggests that targeting iCCM solely based on geographic barriers may need to be reconsidered.

  16. The road map towards providing a robust Raman spectroscopy-based cancer diagnostic platform and integration into clinic

    Science.gov (United States)

    Lau, Katherine; Isabelle, Martin; Lloyd, Gavin R.; Old, Oliver; Shepherd, Neil; Bell, Ian M.; Dorney, Jennifer; Lewis, Aaran; Gaifulina, Riana; Rodriguez-Justo, Manuel; Kendall, Catherine; Stone, Nicolas; Thomas, Geraint; Reece, David

    2016-03-01

    Despite the demonstrated potential as an accurate cancer diagnostic tool, Raman spectroscopy (RS) is yet to be adopted by the clinic for histopathology reviews. The Stratified Medicine through Advanced Raman Technologies (SMART) consortium has begun to address some of the hurdles in its adoption for cancer diagnosis. These hurdles include awareness and acceptance of the technology, practicality of integration into the histopathology workflow, data reproducibility and availability of transferrable models. We have formed a consortium, in joint efforts, to develop optimised protocols for tissue sample preparation, data collection and analysis. These protocols will be supported by provision of suitable hardware and software tools to allow statistically sound classification models to be built and transferred for use on different systems. In addition, we are building a validated gastrointestinal (GI) cancers model, which can be trialled as part of the histopathology workflow at hospitals, and a classification tool. At the end of the project, we aim to deliver a robust Raman based diagnostic platform to enable clinical researchers to stage cancer, define tumour margin, build cancer diagnostic models and discover novel disease bio markers.

  17. Ensembles of indium phosphide nanowires: physical properties and functional devices integrated on non-single crystal platforms

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Nobuhiko P.; Lohn, Andrew; Onishi, Takehiro [University of California, Santa Cruz (United States). Baskin School of Engineering; NASA Ames Research Center, Nanostructured Energy Conversion Technology and Research (NECTAR), Advanced Studies Laboratories, Univ. of California Santa Cruz, Moffett Field, CA (United States); Mathai, Sagi; Li, Xuema; Straznicky, Joseph; Wang, Shih-Yuan; Williams, R.S. [Hewlett-Packard Laboratories, Information and Quantum Systems Laboratory, Palo Alto, CA (United States); Logeeswaran, V.J.; Islam, M.S. [University of California Davis, Electrical and Computer Engineering, Davis, CA (United States)

    2009-06-15

    A new route to grow an ensemble of indium phosphide single-crystal semiconductor nanowires is described. Unlike conventional epitaxial growth of single-crystal semiconductor films, the proposed route for growing semiconductor nanowires does not require a single-crystal semiconductor substrate. In the proposed route, instead of using single-crystal semiconductor substrates that are characterized by their long-range atomic ordering, a template layer that possesses short-range atomic ordering prepared on a non-single-crystal substrate is employed. On the template layer, epitaxial information associated with its short-range atomic ordering is available within an area that is comparable to that of a nanowire root. Thus the template layer locally provides epitaxial information required for the growth of semiconductor nanowires. In the particular demonstration described in this paper, hydrogenated silicon was used as a template layer for epitaxial growth of indium phosphide nanowires. The indium phosphide nanowires grown on the hydrogenerated silicon template layer were found to be single crystal and optically active. Simple photoconductors and pin-diodes were fabricated and tested with the view towards various optoelectronic device applications where group III-V compound semiconductors are functionally integrated onto non-single-crystal platforms. (orig.)

  18. A cylinder based calibration method for integrating a line structured light sensor with a rotation-translation platform

    Science.gov (United States)

    Zhou, Jingbo; Li, Yuehua; Liu, Lijian

    2016-09-01

    As a non-contact measuring apparatus, line structured light sensor (LSLS) can only get one profile of an object without the combination with other motional axes. To achieve the complete 3D measurement, a rotation-translation platform was integrated with the LSLS, and a cylinder based calibration method was also brought out. Firstly, the calibration model was proposed to determine the transformation matrix between the measuring coordinate frame (MCF) and the sensor coordinate frame (SCF). This model relies on the fact that the projection of an arbitrary intersection profile between the laser plane and the cylinder in its axis direction lies on a circle with a radius equal to the cylinder. Then, for a specified rotated angle and translated position of the object, the measured data from the SCF could all be transformed into the MCF, and the complete surface data could be obtained. Finally, a cylinder and a rectangular block were inspected by the proposed method. The surface data was successfully obtained and their intersection profiles indicate a high measuring accuracy of the proposed method. The method was further verified by the measured results of a screw surface.

  19. Towards a fully functional integrated photonic-electronic platform via a single SiGe growth step

    Science.gov (United States)

    Littlejohns, Callum G.; Dominguez Bucio, Thalia; Nedeljkovic, Milos; Wang, Hong; Mashanovich, Goran Z.; Reed, Graham T.; Gardes, Frederic Y.

    2016-01-01

    Silicon-germanium (Si1-xGex) has become a material of great interest to the photonics and electronics industries due to its numerous interesting properties including higher carrier mobilities than Si, a tuneable lattice constant, and a tuneable bandgap. In previous work, we have demonstrated the ability to form localised areas of single crystal, uniform composition SiGe-on-insulator. Here we present a method of simultaneously growing several areas of SiGe-on-insulator on a single wafer, with the ability to tune the composition of each localised SiGe area, whilst retaining a uniform composition in that area. We use a rapid melt growth technique that comprises of only a single Ge growth step and a single anneal step. This innovative method is key in working towards a fully integrated photonic-electronic platform, enabling the simultaneous growth of multiple compositions of device grade SiGe for electro-absorption optical modulators operating at a range of wavelengths, photodetectors, and bipolar transistors, on the same wafer. This is achieved by modifying the structural design of the SiGe strips, without the need to modify the growth conditions, and by using low cost, low thermal-budget methods.

  20. 基于SOA的舰船安全平台集成架构%Integrated Architecture of Ship Security Platform Based on SOA

    Institute of Scientific and Technical Information of China (English)

    郭文刚

    2014-01-01

    舰船安全信息化集成的不断深入发展使舰船安全平台需求也发生了一些变化,舰船的安全设施和安全系统的服务化集成成为舰船安全建设的一个亟待解决的问题。针对这种情况,本文提出基于 SOA 的舰船安全平台集成架构进行设计研究,通过采用EJB组件进行开发,利用WSDL来描述架构集成接口,各个流程的服务设计采用聚类算法,最终设计并实现了一个基于 SOA 的舰船安全平台集成框架,并给出了舰船安全管理平台服务化集成的算法实现,研究结果表明,数字化舰船中的舰船安全设备与其他舰船安全信息系统可以实现无缝集成,较好的解决舰船安全平台信息资源不能有效共享问题,可以在武器平台舰船信息安全系统里进行实际应用。%The deep development of information-integration of ship security changes the need of ship security platform. The integration of ship security equipment and security system becomes a problem urgently to be solved in ship safety construction. In view of this, this paper proposes the design of integrated architecture of ship security platform based on SOA. EJB components will be used to develop the system and WSDL will be applied to describe the architecture integration interface. Added that each process of service designs is using the clustering algorithm, it aims to achieve an integrated architecture of ship security platform based on SOA, and also shows the algorithm implementation of service integration of ship safety management platform. The research proves that it can realize a seamless integration of ship safety equipment and other ship safety information system in digital ship. It effectively solved the problem that ship security platform information resources cannot be shared each other, and can be applied in the weapon platform ship information security system practically.

  1. Improvement in shelf life of minimally processed cilantro leaves through integration of kinetin pretreatment and packaging interventions: Studies on microbial population dynamics, biochemical characteristics and flavour retention.

    Science.gov (United States)

    Ranjitha, K; Shivashankara, K S; Sudhakar Rao, D V; Oberoi, Harinder Singh; Roy, T K; Bharathamma, H

    2017-04-15

    Effect of integrating optimized combination of pretreatment with packaging on shelf life of minimally processed cilantro leaves (MPCL) was appraised through analysis of their sensory attributes, biochemical characteristics, microbial population and flavour profile during storage. Minimally pretreated cilantro leaves pretreated with 50ppm kinetin and packed in 25μ polypropylene bags showed a shelf life of 21days. Optimized combination helped in efficiently maintaining sensory parameters, flavour profile, and retention of antioxidants in MPCL until 21days. Studies conducted on the effect of optimized combination on microbial population and flavour profile revealed that among different microorganisms, pectinolysers had a significant effect on spoilage of MPCL and their population of ⩽3.59logcfu/g was found to be acceptable. Principal component analysis of headspace volatiles revealed that (E)-2-undecenal, (E)-2-hexadecenal, (E)-2-tetradecenal & (E)-2-tetradecen-1-ol in stored samples clustered with fresh samples and therefore, could be considered as freshness indicators for MPCL.

  2. Integrated micro-biochemical approach for phytoremediation of cadmium and lead contaminated soils using Gladiolus grandiflorus L cut flower.

    Science.gov (United States)

    Mani, Dinesh; Kumar, Chitranjan; Patel, Niraj Kumar

    2016-02-01

    The potential of vermicompost, elemental sulphur, Thiobacillus thiooxidans and Pseudomonas putida for phytoremediation is well known individually but their integrated approach has not been discovered so far. The present work highlights the consideration of so far overlooked aspects of their integrated treatment by growing the ornamental plant, Gladiolus grandiflorus L in uncontaminated and sewage-contaminated soils (sulphur-deficient alluvial Entisols, pH 7.6-7.8) for phytoremediation of cadmium and lead under pot experiment. Between vermicompost and elemental sulphur, the response of vermicompost was higher towards improvement in the biometric parameters of plants, whereas the response of elemental sulphur was higher towards enhanced bioaccumulation of heavy metals under soils. The integrated treatment (T7: vermicompost 6g and elemental sulphur 0.5gkg(-1) soil and co-inoculation of the plant with T. thiooxidans and P. putida) was found superior in promoting root length, plant height and dry biomass of the plant. The treatment T7 caused enhanced accumulation of Cd up to 6.96 and 6.45mgkg(-1) and Pb up to 22.6 and 19.9mgkg(-1) in corm and shoot, respectively at the contaminated soil. T7 showed maximum remediation efficiency of 0.46% and 0.19% and bioaccumulation factor of 2.92 and 1.21 and uptake of 6.75 and 21.4mgkg(-1) dry biomass for Cd and Pb respectively in the contaminated soil. The integrated treatment T7 was found significant over the individual treatments to promote plant growth and enhance phytoremediation. Hence, authors conclude to integrate vermicompost, elemental sulphur and microbial co-inoculation for the enhanced clean-up of Cd and Pb-contaminated soils.

  3. AnyExpress: Integrated toolkit for analysis of cross-platform gene expression data using a fast interval matching algorithm

    Directory of Open Access Journals (Sweden)

    Jung Hyunchul

    2011-03-01

    Full Text Available Abstract Background Cross-platform analysis of gene express data requires multiple, intricate processes at different layers with various platforms. However, existing tools handle only a single platform and are not flexible enough to support custom changes, which arise from the new statistical methods, updated versions of reference data, and better platforms released every month or year. Current tools are so tightly coupled with reference information, such as reference genome, transcriptome database, and SNP, which are often erroneous or outdated, that the output results are incorrect and misleading. Results We developed AnyExpress, a software package that combines cross-platform gene expression data using a fast interval-matching algorithm. Supported platforms include next-generation-sequencing technology, microarray, SAGE, MPSS, and more. Users can define custom target transcriptome database references for probe/read mapping in any species, as well as criteria to remove undesirable probes/reads. AnyExpress offers scalable processing features such as binding, normalization, and summarization that are not present in existing software tools. As a case study, we applied AnyExpress to published Affymetrix microarray and Illumina NGS RNA-Seq data from human kidney and liver. The mean of within-platform correlation coefficient was 0.98 for within-platform samples in kidney and liver, respectively. The mean of cross-platform correlation coefficients was 0.73. These results confirmed those of the original and secondary studies. Applying filtering produced higher agreement between microarray and NGS, according to an agreement index calculated from differentially expressed genes. Conclusion AnyExpress can combine cross-platform gene expression data, process data from both open- and closed-platforms, select a custom target reference, filter out undesirable probes or reads based on custom-defined biological features, and perform quantile-normalization with

  4. Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors

    Directory of Open Access Journals (Sweden)

    Chenjie Fei

    2016-03-01

    as unique biochemical signaling networks.

  5. 微博与图书馆网站互动平台的整合%Integration of Micro-blog with the Interactive Platform of Library Website

    Institute of Scientific and Technical Information of China (English)

    赵文金

    2012-01-01

    微博作为一种新兴的信息互动交流平台,已被越来越多的图书馆所使用;而网站作为图书馆传统的宣传与互动交流主平台,应与微博进行有效的整合,以期取得效益的最大化。文章讨论了微博与图书馆网站互动平台整合的需求性与可行性,以实例形式阐述了实现整合的方式、方法,并提出了整合配置过程中需要注意的一些问题。%As a new type of interactive platform, Micro-blog has been increasingly applied in libraries. In order to obtain the maximized benefits, the library website, as a traditional publicity and interaction platform, should be well integrated with the Microblog. This article discusses the demands and the feasibility of the integration mentioned a- bove. Then it explains how to achieve the integrated interactive platform in the form of case study, Finally it lists a number of potential problems that occur in the process of integration.

  6. An integrated sample pretreatment platform for quantitative N-glycoproteome analysis with combination of on-line glycopeptide enrichment, deglycosylation and dimethyl labeling

    Energy Technology Data Exchange (ETDEWEB)

    Weng, Yejing; Qu, Yanyan; Jiang, Hao; Wu, Qi [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Zhang, Lihua, E-mail: lihuazhang@dicp.ac.cn [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Yuan, Huiming [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); Zhou, Yuan [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China); University of the Chinese Academy of Sciences, Beijing 100039 (China); Zhang, Xiaodan; Zhang, Yukui [National Chromatographic Research and Analysis Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)

    2014-06-23

    Highlights: • An integrated platform for quantitative N-glycoproteome analysis was established. • On-line enrichment, deglycosylation and labeling could be achieved within 160 min. • A N{sub 2}-assisted interface was applied to improve the compatibility of the platform. • The platform exhibited improved quantification accuracy, precision and throughput. - Abstract: Relative quantification of N-glycoproteomes shows great promise for the discovery of candidate biomarkers and therapeutic targets. The traditional protocol for quantitative analysis of glycoproteomes is usually off-line performed, and suffers from long sample preparation time, and the risk of sample loss or contamination due to manual manipulation. In this study, a novel integrated sample preparation platform for quantitative N-glycoproteome analysis was established, with combination of online N-glycopeptide capture by a HILIC column, sample buffer exchange by a N{sub 2}-assisted HILIC–RPLC interface, deglycosylation by a hydrophilic PNGase F immobilized enzymatic reactor (hIMER) and solid dimethyl labeling on a C18 precolumn. To evaluate the performance of such a platform, two equal aliquots of immunoglobulin G (IgG) digests were sequentially pretreated, followed by MALDI-TOF MS analysis. The signal intensity ratio of heavy/light (H/L) labeled deglycosylated peptides with the equal aliquots was 1.00 (RSD = 6.2%, n = 3), much better than those obtained by the offline protocol, with H/L ratio as 0.76 (RSD = 11.6%, n = 3). Additionally, the total on-line sample preparation time was greatly shortened to 160 min, much faster than that of offline approach (24 h). Furthermore, such an integrated pretreatment platform was successfully applied to analyze the two kinds of hepatocarcinoma ascites syngeneic cell lines with high (Hca-F) and low (Hca-P) lymph node metastasis rates. For H/L labeled Hca-P lysates with the equal aliquots, 99.6% of log 2 ratios (H/L) of quantified glycopeptides ranged from −1

  7. Vertical One-Dimensional Photonic Crystal Platforms for Label-Free (Bio)Sensing: Towards Drop-And- Measure Applications

    CERN Document Server

    Barillaro, Giuseppe

    2015-01-01

    In this work, all-silicon, integrated optofluidic platforms, fabricated by electrochemical micromachining technology, making use of vertical, one-dimensional high-aspect- ratio photonic crystals for flow-through (bio)sensing applications are reviewed. The potential of such platforms for point-of-care applications is discussed for both pressure-driven and capillarity- driven operations with reference to refractometry and biochemical sensing.

  8. Cost-effective improvements of a rotating platform by integration of a high-accuracy inclinometer and encoders for attitude evaluation

    Science.gov (United States)

    Wen, Chenyang; He, Shengyang; Bu, Changgen; Hu, Peida

    2017-01-01

    Attitude heading reference systems (AHRSs) based on micro-electromechanical system (MEMS) inertial sensors are widely used because of their low cost, light weight, and low power. However, low-cost AHRSs suffer from large inertial sensor errors. Therefore, experimental performance evaluation of MEMS-based AHRSs after system implementation is necessary. High-accuracy turntables can be used to verify the performance of MEMS-based AHRSs indoors, but they are expensive and unsuitable for outdoor tests. This study developed a low-cost two-axis rotating platform for indoor and outdoor attitude determination. A high-accuracy inclinometer and encoders were integrated into the platform to improve the achievable attitude test accuracy. An attitude error compensation method was proposed to calibrate the initial attitude errors caused by the movements and misalignment angles of the platform. The proposed attitude error determination method was examined through rotating experiments, which showed that the standard deviations of the pitch and roll errors were 0.050° and 0.090°, respectively. The pitch and roll errors both decreased to 0.024° when the proposed attitude error determination method was used. This decrease validates the effectiveness of the compensation method. Experimental results demonstrated that the integration of the inclinometer and encoders improved the performance of the low-cost, two-axis, rotating platform in terms of attitude accuracy.

  9. Research on Integrated Platform System of Electric Propulsion Ship%电力推进船舶综合平台系统研究

    Institute of Scientific and Technical Information of China (English)

    陈颖; 王征; 赵党军; 郜世杰

    2011-01-01

    介绍了船舶电力推进系统的发展及其应用,提出了电力推进船舶综合平台系统,分析了该系统的组成及功能,研究了综合平台系统的关键技术,展望了电力推进船舶的未来发展趋势。%The development and applications of ship electric propulsion system are introduced.The integrated platform system of electric propulsion ship is presented.The components and functions of the system are analyzed.The techniques of integrated platform system

  10. 一个化工过程运行系统的多层信息集成平台%A Multi-layer Information Integration Platform for Chemical Process Operation Systems

    Institute of Scientific and Technical Information of China (English)

    钱宇; 李荷华; 李秀喜

    2004-01-01

    In the process industry, automation and process control systems are widely implemented, information integration is however far away from satisfactory. It remains a hard job for senior managers to make decisions based on the plant-wide real-time integrated information. This paper proposes a multi-layer information integration platform. In the data integration level, the standard for the exchange of product (STEP) and the extensible markup language (XML) are used to unify these data of the chemical process. In the model integration level, the models are integrated by using the neutral model repository and CAPE-OPEN. In the integration of process task, the common object request broker architecture (CORBA) is used as the communication mediator. The XML is taken as the data standard. A uniform information platform is thus constructed and realized. The proposed information integration platform is satisfactorily implemented to solve the Tennessee Eastman (TE) problem.

  11. 基于SOA和BPM的集成整合平台研究%Research on the Integration Platform Based on SOA and BPM

    Institute of Scientific and Technical Information of China (English)

    蔡颖嘉

    2013-01-01

    集成整合是当前企业信息化建设的重要内容。从企业信息化集成整合技术的发展趋势出发,分析目前主流的两种集成整合技术---面向服务架构(SOA)和业务流程管理(BPM)的技术特点和优势,探讨两者结合的集成整合平台方案及关键技术,并提出集成整合平台实施的路径和方法。%Integration is the essential content of current informatization of enterprise. Discusses the devel-opment trends of integration technology in enterprise informatization, and analyzes the features and advantages of two mainstream integration technologies:Service-Oriented Architecture (SOA) Technology and Business Process Management (BPM) Technology. Proposes a solution to design an integration platform with a combination of both technology, and finally elaborates the imple-mentation methods and steps in details to construct enterprise application integration platform.

  12. A Practical Perspective on the Design and Implementation of Enterprise Integration Solution to improve QoS using SAP NetWeaver Platform

    Directory of Open Access Journals (Sweden)

    K.Krishna Mohan

    2010-06-01

    Full Text Available Most of the enterprise operations require information from several systems within and outside the enterprise(s. The past few years have seen explosive growth in direct program to program interaction for application integration, removing manual steps yielding tremendous improvements in reliability and efficiency. This paper addresses the practical approach for the design and implementation of Enterprise Application Integration in a heterogeneous environment with SAP NetWeaver Platform (i.e. Exchange Infrastructure (XI/Process Integration (PI using a Customizable Tool named TEmplate based Functional Requirements for Integration Design (TEFRID developed by the author(s to improve the Quality of Service (QoS and reduce the development time and cost with the end-to-end scenario development.

  13. Radio-metabolite analysis of carbon-11 biochemical partitioning to non-structural carbohydrates for integrated metabolism and transport studies.

    Science.gov (United States)

    Babst, Benjamin A; Karve, Abhijit A; Judt, Tatjana

    2013-06-01

    Metabolism and phloem transport of carbohydrates are interactive processes, yet each is often studied in isolation from the other. Carbon-11 ((11)C) has been successfully used to study transport and allocation processes dynamically over time. There is a need for techniques to determine metabolic partitioning of newly fixed carbon that are compatible with existing non-invasive (11)C-based methodologies for the study of phloem transport. In this report, we present methods using (11)C-labeled CO2 to trace carbon partitioning to the major non-structural carbohydrates in leaves-sucrose, glucose, fructose and starch. High-performance thin-layer chromatography (HPTLC) was adapted to provide multisample throughput, raising the possibility of measuring different tissues of the same individual plant, or for screening multiple plants. An additional advantage of HPTLC was that phosphor plate imaging of radioactivity had a much higher sensitivity and broader range of sensitivity than radio-HPLC detection, allowing measurement of (11)C partitioning to starch, which was previously not possible. Because of the high specific activity of (11)C and high sensitivity of detection, our method may have additional applications in the study of rapid metabolic responses to environmental changes that occur on a time scale of minutes. The use of this method in tandem with other (11)C assays for transport dynamics and whole-plant partitioning makes a powerful combination of tools to study carbohydrate metabolism and whole-plant transport as integrated processes.

  14. A Novel Laser Direct Writing System Integrated with A&F XXY Alignment Platform for Rapid Fabrication of Flexible Electronics

    Directory of Open Access Journals (Sweden)

    Yi-Kai Liu

    2015-05-01

    Full Text Available In this study, a novel laser direct synthesis and pattering technology is applied in conjunction with an A&F XXY alignment platform to rapidly fabricate flexible conductors on a polymer substrate (polyimide film with designated patterns. In the process, a focused continuous wave green laser was focused onto the polymer substrate that is mounted and directed using the XXY alignment platform. The focused laser energy absorbed by the polymer substrate is used to heat the transparent and particle-free reactive silver ink on the polymer substrate surface. With appropriate programing of the XXY alignment platform motion to control the laser scanning parameters, silver patterns with good electrical conductivity were successfully obtained. This technology can be operated directly at atmospheric pressure and room temperature. It does not require the use of vacuum chamber, oven and photo-mask, etc. Therefore, this novel technology and system offers a new approach to the cost-effective and green fabrication for flexible electronics. The compact size and excellent stability of the XXY alignment platform make the fabrication system even more competitive. In particular, the programmable small radius plane rotation function of the XXY alignment platform provides flexibility in the pattern design with turnings while keeps the uniformity of the resulted micro metal lines.

  15. Simulating biochemical physics with computers: 1. Enzyme catalysis by phosphotriesterase and phosphodiesterase; 2. Integration-free path-integral method for quantum-statistical calculations

    Science.gov (United States)

    Wong, Kin-Yiu

    We have simulated two enzymatic reactions with molecular dynamics (MD) and combined quantum mechanical/molecular mechanical (QM/MM) techniques. One reaction is the hydrolysis of the insecticide paraoxon catalyzed by phosphotriesterase (PTE). PTE is a bioremediation candidate for environments contaminated by toxic nerve gases (e.g., sarin) or pesticides. Based on the potential of mean force (PMF) and the structural changes of the active site during the catalysis, we propose a revised reaction mechanism for PTE. Another reaction is the hydrolysis of the second-messenger cyclic adenosine 3'-5'-monophosphate (cAMP) catalyzed by phosphodiesterase (PDE). Cyclicnucleotide PDE is a vital protein in signal-transduction pathways and thus a popular target for inhibition by drugs (e.g., ViagraRTM). A two-dimensional (2-D) free-energy profile has been generated showing that the catalysis by PDE proceeds in a two-step SN2-type mechanism. Furthermore, to characterize a chemical reaction mechanism in experiment, a direct probe is measuring kinetic isotope effects (KIEs). KIEs primarily arise from internuclear quantum-statistical effects, e.g., quantum tunneling and quantization of vibration. To systematically incorporate the quantum-statistical effects during MD simulations, we have developed an automated integration-free path-integral (AIF-PI) method based on Kleinert's variational perturbation theory for the centroid density of Feynman's path integral. Using this analytic method, we have performed ab initio pathintegral calculations to study the origin of KIEs on several series of proton-transfer reactions from carboxylic acids to aryl substituted alpha-methoxystyrenes in water. In addition, we also demonstrate that the AIF-PI method can be used to systematically compute the exact value of zero-point energy (beyond the harmonic approximation) by simply minimizing the centroid effective potential.

  16. Temperature and salinity profiles from CTD casts from the VALKIRIYA and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 January 1991 to 31 January 1991 (NODC Accession 9100035)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VALKIRIYA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  17. Temperature and salinity profiles from CTD casts from the PARIZEAU and other PLATFORMS from a World-Wide distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 October 1988 to 31 October 1988 (NODC Accession 8800296)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the PARIZEAU and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  18. Temperature and salinity profiles from CTD casts from the ARGOS and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 November 1989 to 30 November 1989 (NODC Accession 8900297)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the ARGOS and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  19. Temperature and salinity profiles from CTD casts from the VALDIVIA and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 April 1991 to 30 April 1991 (NODC Accession 9100087)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VALDIVIA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  20. Temperature profiles from expendable bathythermograph (XBT) casts from the BARTLETT and Other Platforms in the North Pacific Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 14 March 1974 to 04 May 1974 (NODC Accession 7400432)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the BARTLETT and Other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected by the...

  1. A New Approach of Electronics and Photonics Convergence on Si CMOS Platform: How to Reduce Device Diversity of Photonics for Integration

    Directory of Open Access Journals (Sweden)

    Kazumi Wada

    2008-01-01

    Full Text Available Integrated photonics via Si CMOS technology has been a strategic area since electronics and photonics convergence should be the next platform for information technology. The platform is recently referred to as “Si photonics” that attracts much interest of researchers in industries as well as academia in the world. The main goal of Si Photonics is currently to reduce material diversity of photonic devices to pursuing CMOS-compatibility. In contrast, the present paper proposes another route of Si Photonics, reducing diversity of photonic devices. The proposed device unifying functionality of photonics is a microresonator with a pin diode structure that enables the Purcell effect and Franz-Keldysh effect to emit and to modulate light from SiGe alloys.

  2. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  3. National platform electromobility. Interim report of the working group 3 Load infrastructure and rid integration; Nationale Plattform Elektromobilitaet. Zwischenbericht der Arbeitsgruppe 3 Lade-Infrastruktur und Netzintegration

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Stefan [E.ON AG, Duesseldorf (Germany). Political Affairs and Communications Energy Mix, Environment, Efficiency; Ledwon, Martin (comps.) [Siemens AG, Berlin (Germany). Government Affairs

    2010-07-01

    The contribution under consideration reports on the first intermediate results of the working group 3 ''Load infrastructure and grid integration'' of the national platform electromobility. Next to the representation of the general objective of this working group, the following aspects are considered: (a) Electromobility in the field of tension between the power supply system and renewable production; (b) Possible network loads due to the integration of electrically powered vehicles; (c) Requirements concerning the load infrastructure; (d) Technology development of the load point; (e) Potentials by the integration of electrical mobiles into the Smart Grid; (f) Research and Development roadmap. This contribution finishes with a presentation of a concrete conversion plan for the demand of infrastructure.

  4. Systematic Integration of Innovation in Process Improvement Projects Using the Enhanced Sigma-TRIZ Algorithm and Its Effective Use by Means of a Knowledge Management Software Platform

    Directory of Open Access Journals (Sweden)

    Mircea FULEA

    2009-01-01

    Full Text Available In an evolving, highly turbulent and uncertain socio-economic environment, organizations must consider strategies of systematic and continuous integration of innovation within their business systems, as a fundamental condition for sustainable development. Adequate methodologies are required in this respect. A mature framework for integrating innovative problem solving approaches within business process improvement methodologies is proposed in this paper. It considers a TRIZ-centred algorithm in the improvement phase of the DMAIC methodology. The new tool is called enhanced sigma-TRIZ. A case study reveals the practical application of the proposed methodology. The integration of enhanced sigma-TRIZ within a knowledge management software platform (KMSP is further described. Specific developments to support processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application in a friendly and effective way within the KMSP are also highlighted.

  5. Development on integrated simulation platform for opto-electrical tracking system%光电跟踪系统集成仿真系统的开发

    Institute of Scientific and Technical Information of China (English)

    史建亮; 任戈; 谭毅

    2012-01-01

    In order to estimate the performance of opto-electrical tracking system, the integrated simu-lation platform should be developed, which is comprised of structure, control and optics. Based on the object track modeling, the tracking strategy for system is analyzed, and tracking optics principle and con-trol principle are studied separately. Finally, virtual reality is introduced. Integrated simulation platform is implemented in Matlab/Simulink. Using the platform, an example is analyzed, and the results accord with the fact. So the platform can be used in design and performance estimation in future.%为了评估光电跟踪系统的性能,需要开发一套集结构、控制和光学于一体的集成仿真平台.为此从目标运动轨迹模型的建立出发,分析了系统对目标的跟踪策略,并对系统的跟踪光学原理和控制原理分别进行了研究,并引入虚拟现实技术.以此为基础在Matlab/Simulink环境中搭建了集成仿真平台,并对一实例进行了仿真分析,其仿真结果符合实际情况,可应用于今后的系统设计与性能评估工作.

  6. On-chip generation and demultiplexing of quantum correlated photons using a silicon-silica monolithic photonic integration platform.

    Science.gov (United States)

    Matsuda, Nobuyuki; Karkus, Peter; Nishi, Hidetaka; Tsuchizawa, Tai; Munro, William J; Takesue, Hiroki; Yamada, Koji

    2014-09-22

    We demonstrate the generation and demultiplexing of quantum correlated photons on a monolithic photonic chip composed of silicon and silica-based waveguides. Photon pairs generated in a nonlinear silicon waveguide are successfully separated into two optical channels of an arrayed-waveguide grating fabricated on a silica-based waveguide platform.

  7. A Bacterial Analysis Platform: An Integrated System for Analysing Bacterial Whole Genome Sequencing Data for Clinical Diagnostics and Surveillance

    DEFF Research Database (Denmark)

    Thomsen, Martin Christen Frølund; Ahrenfeldt, Johanne; Bellod Cisneros, Jose Luis;

    2016-01-01

    web-based tools we developed a single pipeline for batch uploading of whole genome sequencing data from multiple bacterial isolates. The pipeline will automatically identify the bacterial species and, if applicable, assemble the genome, identify the multilocus sequence type, plasmids, virulence genes...... and made publicly available, providing easy-to-use automated analysis of bacterial whole genome sequencing data. The platform may be of immediate relevance as a guide for investigators using whole genome sequencing for clinical diagnostics and surveillance. The platform is freely available at: https......Recent advances in whole genome sequencing have made the technology available for routine use in microbiological laboratories. However, a major obstacle for using this technology is the availability of simple and automatic bioinformatics tools. Based on previously published and already available...

  8. Integrating syngas fermentation with the carboxylate platform and yeast fermentation to reduce medium cost and improve biofuel productivity.

    Science.gov (United States)

    Richter, Hanno; Loftus, Sarah E; Angenent, Largus T

    2013-01-01

    To ensure economic implementation of syngas fermentation as a fuel-producing platform, engineers and scientists must both lower operating costs and increase product value. A considerable part of the operating costs is spent to procure chemicals for fermentation medium that can sustain sufficient growth of carboxydotrophic bacteria to convert synthesis gas (syngas: carbon monoxide, hydrogen, and carbon dioxide) into products such as ethanol. Recently, we have observed that wildtype carboxydotrophic bacteria (including Clostridium ljungdahlii) can produce alcohols with a longer carbon chain than ethanol via syngas fermentation when supplied with the corresponding carboxylic acid precursors, resulting in possibilities of increasing product value. Here, we evaluated a proof-of-concept system to couple syngas fermentation with the carboxylate platform to both lower medium costs and increase product value. Our carboxylate platform concept consists of an open culture, anaerobic fermentor that is fed with corn beer from conventional yeast fermentation in the corn kernel-to-ethanol industry. The mixed-culture anaerobic fermentor produces a mixture ofcarboxylic acids at dilute concentrations within the carboxylate platform effluent (CPE). Besides providing carboxylic acid precursors, this effluent may represent an inexpensive growth medium. An elemental analysis demonstrated that the CPE lacked certain essential trace metals, but contained ammonium, phosphate, sodium, chloride, potassium, magnesium, calcium, and sulphate at required concentrations. CPE medium with the addition of a trace metal solution supported growth and alcohol production of C. ljungdahlii at similar or better levels compared with an optimized synthetic medium (modified ATCC 1754 medium). Other expensive supplements, such as yeast extract or macro minerals (ammonium, phosphate), were not required. Finally, n-butyric acid and n-caproic acid within the CPE were converted into their corresponding medium

  9. 煤炭信息化网络融合传输平台的构建%Coal information network integration transmission platform construction

    Institute of Scientific and Technical Information of China (English)

    牛立新

    2012-01-01

    The Research of mine automation and management information network convergence platform and software application platform, which is the main direction of mining information technology and the active demand of mining information technology in the future. Meanwhile enterprise constructs 10 Gbit / s or even 40 Gbit / s private converged network which is the inevitable trend. Based on the construction project of Zhengzhou coal industry group integrated information network transmission platform, this paper which discusses the project in the construction process of coal private network, points out that the key technologies and matters needing attention.%矿井自动化和管理信息化网络融合平台及软件应用平台建设研究是煤炭信息化的主攻方向和煤炭信息化发展的迫切需求,专网企业建设10Gbit/s甚至40Gbit/s融合网络是必然趋势.以郑煤集团信息化网络融合传输平台建设项目为背景,论述了该项目在煤炭专网中的建设过程并指出了关键技术和注意事项.

  10. Design and Simulation of Material-Integrated Distributed Sensor Processing with a Code-Based Agent Platform and Mobile Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Stefan Bosse

    2015-02-01

    Full Text Available Multi-agent systems (MAS can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  11. Design and simulation of material-integrated distributed sensor processing with a code-based agent platform and mobile multi-agent systems.

    Science.gov (United States)

    Bosse, Stefan

    2015-02-16

    Multi-agent systems (MAS) can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG) model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container) and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  12. Integrative assessment of potential effects of dioxins and related compounds in wild Baikal seals (Pusa sibirica): application of microarray and biochemical analyses.

    Science.gov (United States)

    Hirakawa, Shusaku; Imaeda, Daisuke; Nakayama, Kei; Udaka, Masayuki; Kim, Eun-Young; Kunisue, Tatsuya; Ogawa, Masako; Matsuda, Tomonari; Matsui, Saburo; Petrov, Evgeny A; Batoev, Valeriy B; Tanabe, Shinsuke; Iwata, Hisato

    2011-09-01

    We have previously indicated that accumulation of chlorinated dioxins and related compounds (DRCs) induced cytochrome P450 (CYP) 1A1, 1A2 and 1B1 isozymes in the liver of wild Baikal seals (Pusa sibirica). Here we attempt to assess the potential effects of DRCs triggered by the induction of these CYP1 isozymes in this species, using an integrative approach, combining gene expression monitoring and biochemical assays. To screen genes that may potentially respond to the exposure of DRCs, we constructed a custom cDNA oligo array that can target mRNAs in Baikal seals, and monitored hepatic mRNA expression levels in the wild population. Correlation analyses between the hepatic total 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (TEQs) and mRNA levels supported our previous findings that high accumulation of DRCs induces the transcription of CYP1A1, CYP1A2 and CYP1B1 genes. In addition, our integrative assessment indicated that the chronic exposure to DRCs may alter the hepatic transcript levels of genes related to oxidative stress, Fe ion homeostasis, and inflammatory responses. The expression levels of CYP1A2 showed significant positive correlations with levels of malondialdehyde, a biomarker of lipid peroxidation, and of etheno-dA, a DNA adduct, suggesting that the lipid peroxidation may be enhanced through the production of reactive oxygen species (ROS) triggered by CYP1A2 induction. Moreover, there was a positive correlation between heme oxygenase activities and malondialdehyde levels, suggesting the prompted heme degradation by ROS. Fetuin-A levels, which are suppressed by inflammation, showed a significant negative correlation with TEQ levels, and hepcidin levels, which are conversely increased by inflammation, had significant positive correlations with malondialdehyde and etheno-dA levels, implying the progression of inflammation by DRC-induced oxidative stress. Taken together, we propose here that wild Baikal seals may suffer from effects of chronic

  13. Integration of the DRAGON5/DONJON5 codes in the SALOME platform for performing multi-physics calculations in nuclear engineering

    Science.gov (United States)

    Hébert, Alain

    2014-06-01

    We are presenting the computer science techniques involved in the integration of codes DRAGON5 and DONJON5 in the SALOME platform. This integration brings new capabilities in designing multi-physics computational schemes, with the possibility to couple our reactor physics codes with thermal-hydraulics or thermo-mechanics codes from other organizations. A demonstration is presented where two code components are coupled using the YACS module of SALOME, based on the CORBA protocol. The first component is a full-core 3D steady-state neuronic calculation in a PWR performed using DONJON5. The second component implement a set of 1D thermal-hydraulics calculations, each performed over a single assembly.

  14. Application Integration Platform Applied in the Shenhua Informatization%应用集成平台在神华信息化中的应用

    Institute of Scientific and Technical Information of China (English)

    李文慧; 李晓蕴

    2013-01-01

    Dozens of application system have been planned and constructed in the process of SH217 information construction. Based on SAP PI, it severs as an application integration platform to be implemented for basic software technology of SH217 project. This paper introduces the general structure, technological architecture, application scene and implemented specification of application integration platform. Besides, it also represents the general protocol adapter that is provided by SAP PI to connect each business system, reducing the coupling degree between the systems. Through the configuration message routing and data mapping realize smooth connection between heterogeneous system, and horizontal integration between ERP applications system in group headquarters and application system, vertical integration between group headquarters and subordinate company, avoid point to point information interaction of a great deal of heterogeneous platform, reduce the integrated complex degree and save the enterprise cost, realizing the information sharing and business synergy.%  在神华集团 SH217信息化建设过程中,规划和建设了数十个应用系统。作为 SH217工程中基础软件技术平台的应用集成平台基于 SAP PI 进行实施,本文介绍了应用集成平台的总体架构和技术架构、应用场景以及实施规范,描述了如何通过 SAP PI 提供的业界通用协议适配器连接各业务系统,降低各系统之间的耦合程度,通过配置消息路由、数据映射实现异构系统间顺畅连接,实现集团总部 ERP 等应用系统之间的横向集成及集团总部应用系统与下属公司应用系统之间的纵向集成,避免了大量异构平台之间点对点的信息交互,降低了集成的复杂程度,节省了企业成本,实现了信息共享和业务协同。

  15. Intrant ELISA: A Novel Approach to Fabrication of Electrospun Fiber Mat-Assisted Biosensor Platforms and Their Integration within Standard Analytical Well Plates

    Directory of Open Access Journals (Sweden)

    Samira Hosseini

    2016-11-01

    Full Text Available A combination of far-field electrospinning (FFES and free-radical polymerization has been used to fabricate coated electrospun polymer fiber mats as a new type of biosensor platform. Poly (3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV electrospun fibers were dip-coated with different compositions of poly methyl methacrylate-co-methacrylic acid (poly(MMA-co-MAA. This synergistic approach utilizes large specific surface area of PHBV fibers and co-polymer coatings that feature an optimum concentration of surface carboxyl (–COOH groups. The platform surface morphology, porosity and tunable hydrophobicity enhance biomolecular interactions via plurality of molecular forces. These customized fiber mats have been integrated into a newly designed 96-well plate called an “intrant enzyme-linked immunosorbent assay” or i-ELISA. I-ELISA allows colorimetric sandwich assay to be carried out without any modifications or additional steps in ELISA methodology. By introducing the fiber mats in fabrication of i-ELISA via extensions on the lid, we address some of the limitations of the previous designs while demonstrating an enhanced signal intensity up to 12 times higher than that of conventional assays. With improved sensitivity, specificity and accuracy in the detection of dengue virus, i-ELISA has proven to be a reliable platform for biomolecular recognition. The proposed fiber mat-assisted well plate in this study holds great potential as a universal approach for integration of different types of fiber mats with pre-designed specific properties in order to enhance the detection sensitivity of the assay.

  16. A computational systems biology software platform for multiscale modeling and simulation: Integrating whole-body physiology, disease biology, and molecular reaction networks

    Directory of Open Access Journals (Sweden)

    Thomas eEissing

    2011-02-01

    Full Text Available Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multi-scale by nature, project work and software tools usually focus on isolated aspects of drug action, such as pharmacokinetics at the organism scale or pharmacodynamic interaction on the molecular level. We present a modeling and simulation software platform consisting of PK-Sim® and MoBi® capable of building and simulating models that integrate across biological scales. A prototypical multiscale model for the progression of a pancreatic tumor and its response to pharmacotherapy is constructed and virtual patients are treated with a prodrug activated by hepatic metabolization. Tumor growth is driven by signal transduction leading to cell cycle transition and proliferation. Free tumor concentrations of the active metabolite inhibit Raf kinase in the signaling cascade and thereby cell cycle progression. In a virtual clinical study, the individual therapeutic outcome of the chemotherapeutic intervention is simulated for a large population with heterogeneous genomic background. Thereby, the platform allows efficient model building and integration of biological knowledge and prior data from all biological scales. Experimental in vitro model systems can be linked with observations in animal experiments and clinical trials. The interplay between patients, diseases, and drugs and topics with high clinical relevance such as the role of pharmacogenomics, drug-drug or drug-metabolite interactions can be addressed using this mechanistic, insight driven multiscale modeling approach.

  17. Integrating medicinal chemistry, organic/combinatorial chemistry, and computational chemistry for the discovery of selective estrogen receptor modulators with Forecaster, a novel platform for drug discovery.

    Science.gov (United States)

    Therrien, Eric; Englebienne, Pablo; Arrowsmith, Andrew G; Mendoza-Sanchez, Rodrigo; Corbeil, Christopher R; Weill, Nathanael; Campagna-Slater, Valérie; Moitessier, Nicolas

    2012-01-23

    As part of a large medicinal chemistry program, we wish to develop novel selective estrogen receptor modulators (SERMs) as potential breast cancer treatments using a combination of experimental and computational approaches. However, one of the remaining difficulties nowadays is to fully integrate computational (i.e., virtual, theoretical) and medicinal (i.e., experimental, intuitive) chemistry to take advantage of the full potential of both. For this purpose, we have developed a Web-based platform, Forecaster, and a number of programs (e.g., Prepare, React, Select) with the aim of combining computational chemistry and medicinal chemistry expertise to facilitate drug discovery and development and more specifically to integrate synthesis into computer-aided drug design. In our quest for potent SERMs, this platform was used to build virtual combinatorial libraries, filter and extract a highly diverse library from the NCI database, and dock them to the estrogen receptor (ER), with all of these steps being fully automated by computational chemists for use by medicinal chemists. As a result, virtual screening of a diverse library seeded with active compounds followed by a search for analogs yielded an enrichment factor of 129, with 98% of the seeded active compounds recovered, while the screening of a designed virtual combinatorial library including known actives yielded an area under the receiver operating characteristic (AU-ROC) of 0.78. The lead optimization proved less successful, further demonstrating the challenge to simulate structure activity relationship studies.

  18. A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

    Science.gov (United States)

    Eissing, Thomas; Kuepfer, Lars; Becker, Corina; Block, Michael; Coboeken, Katrin; Gaub, Thomas; Goerlitz, Linus; Jaeger, Juergen; Loosen, Roland; Ludewig, Bernd; Meyer, Michaela; Niederalt, Christoph; Sevestre, Michael; Siegmund, Hans-Ulrich; Solodenko, Juri; Thelen, Kirstin; Telle, Ulrich; Weiss, Wolfgang; Wendl, Thomas; Willmann, Stefan; Lippert, Joerg

    2011-01-01

    Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multiscale by nature, project work, and software tools usually focus on isolated aspects of drug action, such as pharmacokinetics at the organism scale or pharmacodynamic interaction on the molecular level. We present a modeling and simulation software platform consisting of PK-Sim(®) and MoBi(®) capable of building and simulating models that integrate across biological scales. A prototypical multiscale model for the progression of a pancreatic tumor and its response to pharmacotherapy is constructed and virtual patients are treated with a prodrug activated by hepatic metabolization. Tumor growth is driven by signal transduction leading to cell cycle transition and proliferation. Free tumor concentrations of the active metabolite inhibit Raf kinase in the signaling cascade and thereby cell cycle progression. In a virtual clinical study, the individual therapeutic outcome of the chemotherapeutic intervention is simulated for a large population with heterogeneous genomic background. Thereby, the platform allows efficient model building and integration of biological knowledge and prior data from all biological scales. Experimental in vitro model systems can be linked with observations in animal experiments and clinical trials. The interplay between patients, diseases, and drugs and topics with high clinical relevance such as the role of pharmacogenomics, drug-drug, or drug-metabolite interactions can be addressed using this mechanistic, insight driven multiscale modeling approach.

  19. Integration of spore-based genetically engineered whole-cell sensing systems into portable centrifugal microfluidic platforms.

    Science.gov (United States)

    Date, Amol; Pasini, Patrizia; Daunert, Sylvia

    2010-09-01

    Bacterial whole-cell biosensing systems provide important information about the bioavailable amount of target analytes. They are characterized by high sensitivity and specificity/selectivity along with rapid response times and amenability to miniaturization as well as high-throughput analysis. Accordingly, they have been employed in various environmental and clinical applications. The use of spore-based sensing systems offers the unique advantage of long-term preservation of the sensing cells by taking advantage of the environmental resistance and ruggedness of bacterial spores. In this work, we have incorporated spore-based whole-cell sensing systems into centrifugal compact disk (CD) microfluidic platforms in order to develop a portable sensing system, which should enable the use of these hardy sensors for fast on-field analysis of compounds of interest. For that, we have employed two spore-based sensing systems for the detection of arsenite and zinc, respectively, and evaluated their analytical performance in the miniaturized microfluidic format. Furthermore, we have tested environmental and clinical samples on the CD microfluidic platforms using the spore-based sensors. Germination of spores and quantitative response to the analyte could be obtained in 2.5-3 h, depending on the sensing system, with detection limits of 1 x 10(-7) M for arsenite and 1 x 10(-6) M for zinc in both serum and fresh water samples. Incorporation of spore-based whole-cell biosensing systems on microfluidic platforms enabled the rapid and sensitive detection of the analytes and is expected to facilitate the on-site use of such sensing systems.

  20. CBS: an open platform that integrates predictive methods and epigenetics information to characterize conserved regulatory features in multiple Drosophila genomes

    Directory of Open Access Journals (Sweden)

    Blanco Enrique

    2012-12-01

    Full Text Available Abstract Background Information about the composition of regulatory regions is of great value for designing experiments to functionally characterize gene expression. The multiplicity of available applications to predict transcription factor binding sites in a particular locus contrasts with the substantial computational expertise that is demanded to manipulate them, which may constitute a potential barrier for the experimental community. Results CBS (Conserved regulatory Binding Sites, http://compfly.bio.ub.es/CBS is a public platform of evolutionarily conserved binding sites and enhancers predicted in multiple Drosophila genomes that is furnished with published chromatin signatures associated to transcriptionally active regions and other experimental sources of information. The rapid access to this novel body of knowledge through a user-friendly web interface enables non-expert users to identify the binding sequences available for any particular gene, transcription factor, or genome region. Conclusions The CBS platform is a powerful resource that provides tools for data mining individual sequences and groups of co-expressed genes with epigenomics information to conduct regulatory screenings in Drosophila.

  1. 企业一体化信息平台的研究与实现%Research and Implementation of the Enterprise Integration Platform

    Institute of Scientific and Technical Information of China (English)

    朱永虎; 赵志勤; 李洁珊; 张晨曼

    2013-01-01

    Enterprise informatization is the integrated of s oftware systems and business data, data is the fundamental of enterprise informatization, we must pay attention to the quality of the data of the business data. Carries out the analysis of business data from two categories: structured and un-structured, through the information integration idea: "one platform, two centers, multi-applica-tion" to establish an application integration platform, completion the management of these two types of data, builds the enterprise data center and enterprise knowledge center, and provides a variety of applications for the upper user, so as to enhance the practical level of enterprise in-formatization. Proposes the way to improve the quality of the data.%  提出企业信息化是软件系统与业务数据的统一体,数据是企业信息化的根本,必须重视业务数据的数据质量。从结构化与非结构化两类对业务数据进行剖析,通过“一平台、二中心、多应用”的信息化集成思路建立一体化应用集成平台,完成了对这两类数据的管理,搭建企业数据中心和企业知识中心,并为上层用户提供各种应用,从而提升企业信息化的实用化水平。提出改善数据质量的途径。

  2. All-optical SR flip-flop based on SOA-MZI switches monolithically integrated on a generic InP platform

    Science.gov (United States)

    Pitris, St.; Vagionas, Ch.; Kanellos, G. T.; Kisacik, R.; Tekin, T.; Broeke, R.; Pleros, N.

    2016-03-01

    At the dawning of the exaflop era, High Performance Computers are foreseen to exploit integrated all-optical elements, to overcome the speed limitations imposed by electronic counterparts. Drawing from the well-known Memory Wall limitation, imposing a performance gap between processor and memory speeds, research has focused on developing ultra-fast latching devices and all-optical memory elements capable of delivering buffering and switching functionalities at unprecedented bit-rates. Following the master-slave configuration of electronic Flip-Flops, coupled SOA-MZI based switches have been theoretically investigated to exceed 40 Gb/s operation, provided a short coupling waveguide. However, this flip-flop architecture has been only hybridly integrated with silica-on-silicon integration technology exhibiting a total footprint of 45x12 mm2 and intra-Flip-Flop coupling waveguide of 2.5cm, limited at 5 Gb/s operation. Monolithic integration offers the possibility to fabricate multiple active and passive photonic components on a single chip at a close proximity towards, bearing promises for fast all-optical memories. Here, we present for the first time a monolithically integrated all-optical SR Flip-Flop with coupled master-slave SOA-MZI switches. The photonic chip is integrated on a 6x2 mm2 die as a part of a multi-project wafer run using library based components of a generic InP platform, fiber-pigtailed and fully packaged on a temperature controlled ceramic submount module with electrical contacts. The intra Flip-Flop coupling waveguide is 5 mm long, reducing the total footprint by two orders of magnitude. Successful flip flop functionality is evaluated at 10 Gb/s with clear open eye diagram, achieving error free operation with a power penalty of 4dB.

  3. Case Study of Integrating an Offshore Wind Farm with Offshore Oil and Gas Platforms and with an Onshore Electrical Grid

    Directory of Open Access Journals (Sweden)

    Wei He

    2013-01-01

    Full Text Available This research project explored the technical feasibility of utilizing an offshore wind farm as a supplementary power source to several electrical grids of offshore oil and gas platforms and providing surplus power to an onshore grid. Three case studies comprising wind farms rated at 20 MW, 100 MW, and 1000 MW have been studied with the focus on (i the operation benefits of CO2/NOx emission reduction, (ii the electrical grid stability, and (iii the technical implementation feasibility. The proposed 20 MW, 100 MW, and 1000 MW wind farm cases are theoretically feasible in terms of the selected technical criteria, although further detailed design operational studies, and economical analysis are required.

  4. Integrated platform for home services using new products and services for senior citizens Call CNAV-CARSAT 2015.

    Science.gov (United States)

    Noguès, Michel; Laune, Daniel; Paccard, Delphine; Coupet, Anne-Laure; Millot-Keurinck, Justine; Bototo, Narjis; Bertrand, Marine; Bousquet, Jean

    2017-03-01

    This project is part of: i) the risks of ageing prevention policy of the French retirement and occupational health insurance agency of Languedoc Roussillon (Carsat-LR) and ii) the European innovation partnership on active and healthy ageing (EIP on AHA). It aims to support senior citizens who live independently and have been identified at risk of frailty on a social or health level. The purpose is to increase legibility as well as technical and financial access to innovations for vulnerable seniors who are remote from the digital era, through a multiservice user-friendly platform. Launched at the end of 2015, the project rallies over 10 actors of the silver economy currently developing personalised ICT tools to improve the safety and comfort of seniors and the coordination between health and social care. The objective is threefold: i) developing new adapted technologies, ii) having them evaluated by retirees and professionals and iii) making them accessible to the ICT web platform which will provide tutorials and prices and collect opinions from users and professionals. 500 retirees selected by CARSAT-LR will be testing these new devices and solutions which will be provided without charge. The following will be evaluated: i) feedback from users; ii) benefits gained through accessing comprehensive and appropriate information; iii) coordination of caregivers and professionals; iv) enjoyment from using the products (access to games, social links, customer confidence, sense of safety). This is a unique opportunity to mobilise solutions in a structured manner, bringing together competing businesses under a consortium agreement. Advantages for these businesses include acceleration of development and availability of their adapted solutions as well as the possibility to test their products on a significant panel of people. Professional caregiver's data follow-up will identify seniors at risk of frailty, proposing preventive actions and local services tailored to their

  5. High-efficiency and wideband interlayer grating couplers in multilayer Si/SiO2/SiN platform for 3D integration of optical functionalities.

    Science.gov (United States)

    Sodagar, Majid; Pourabolghasem, Reza; Eftekhar, Ali A; Adibi, Ali

    2014-07-14

    We have designed interlayer grating couplers with single/double metallic reflectors for Si/SiO(2)/SiN multilayer material platform. Out-of-plane diffractive grating couplers separated by 1.6 μm thick buffer SiO(2) layer are vertically stacked against each other in Si and SiN layers. Geometrical optimization using genetic algorithm coupled with electromagnetic simulations using two-dimensional (2D) finite element method (FEM) results in coupler designs with high peak coupling efficiency of up to 89% for double- mirror and 64% for single-mirror structures at telecom wavelength. Also, 3-dB bandwidths of 40 nm and 50 nm are theoretically predicted for the two designs, respectively. We have fabricated the grating coupler structure with single mirror. Measured values for insertion loss and 3-dB bandwidth in the fabricated single-mirror coupler confirms the theoretical results. This opens up the possibility of low-loss 3D dense integration of optical functionalities in hybrid material platforms.

  6. 基层电大在线平台资源整合研究%Research of the Resources Integration on Grass- roots TV University Online Platform

    Institute of Scientific and Technical Information of China (English)

    吉云辉

    2012-01-01

    The online teaching platform of grass- roots TV University is the main place of open education students to learn. Teaching resources on the platform play an important role in the teaching process. However, the reality is that the teaching resources on grass - roots plaffoml are far unable to meet the requirements of student learning. There- fore, only the online eurrieulum resources are reasonably integrated and continuously enriched, will the resource ad- vantages of TV University system be brought into full play to train the students'good habits of learning by using the In- temet, in order to improve the quality of education.%基层电大在线教学平台是开放教育学生学习的主要场所,平台上的教学资源在教学过程中起着举足轻重的作用。然而,现实情况是基层平台的教学资源远远无法满足学生学习的要求。因此,只有合理地整合和不断充实网上课程资源,才能发挥电大系统资源优势,培养学生利用网络开展学习的良好习惯,使开放教育教学质量得以提升。

  7. 光电综合搜索平台集成化设计%Research on the Integrated Design of Electro-optical Search Platform

    Institute of Scientific and Technical Information of China (English)

    游小嘉; 朱元武; 解志红; 王玉华

    2014-01-01

    Fast target recognition is the premise to weapon attack. Electro-optical search platform is an important reconnaissance equipment under the information condition. Aiming at improving the fast and autonomous target recognition of weapon system,we research on visible camera,IR imager and MMV radar integrated technology. Combing with autonomous recognition and high stability accuracy,detector selection,general design of platform and high stability accuracy control were discussed.%目标的快速捕获是作战武器实施打击的前提,光电综合搜索平台是信息化条件下的重要侦察设备。以提高武器系统快速、自主目标搜索为目标,对可见光摄像机、红外热像仪、毫米波雷达探测综合集成技术进行研究。结合光电综合搜索平台的自主搜索、高精度稳定的要求,从探测器选型、平台总体设计、高精度稳定控制等方面进行了论述。

  8. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing

    DEFF Research Database (Denmark)

    Oprea, Tudor; Nielsen, Sonny Kim; Ursu, Oleg

    2011-01-01

    benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based...

  9. Ricebase: a breeding and genetics platform for rice, integrating individual molecular markers, pedigrees, and whole-genome-based data

    Science.gov (United States)

    Ricebase (http://ricebase.org) is an integrative genomic database for rice (Oryza sativa) with an emphasis on combining data sets in a way that maintains the key links between past and current genetic studies. Ricebase includes DNA sequence data, gene annotations, nucleotide variation data, and mol...

  10. The Requirement Analysis of the Provincial IPTV Integrated Broadcast Control Platform%省级广电IPTV集成播控平台的需求分析

    Institute of Scientific and Technical Information of China (English)

    李文皓

    2013-01-01

    The main features of Internet Protocol Television ( IPTV ) in its interactive capabilities and real-time , select IPTV service , allows users to get high-quality digital media services , real interaction between con-sumers and carriers .In recent years , with the development of IPTV industry , integrated broadcast control plat-form system came into being .The system will use radio and television is responsible for broadcast control , tele-com operators responsible for the transmission of mode , the control and management functions of the provincial radio and television operators to complete the broadcast content , specifically responsible for program manage-ment, authorization control, cost-recovery, user management.The project is part of the complete structure of China triple play content broadcast control , integrated broadcast control platform is the only IPTV content in the provincial areas .Above it connected to the national IPTV central integrated broadcast control total platform integration of all levels of media units and other content providers in the area of this province , the bottom con-nected to the provincial company of China Telecom IPTV content distribution platform and transmission net -work to provide live with Taiwanese characteristics , Carousel , on-demand video program content and network services.%IPTV的主要特点在于其交互能力和实时性,选择IPTV业务,可以让用户得到高品质的数字媒体服务,实现消费者和运营商之间真正的互动。近年来随着IPTV产业的大发展,集成播控平台系统应运而生。该系统采用广电负责播控、电信负责传输的运营模式,各省级广电机构完成内容播出的控制和管理功能,具体负责节目管理、授权控制、费用收取、用户管理等工作。该项目是我国三网融合内容播控完整结构的组成部分,是各省级地区唯一的IPTV内容集成播控平台。它上方连接国家IPTV中央集成播控总平

  11. INTEGRACIÓN DE TECNOLOGÍAS EN UNA PLATAFORMA J2EE DIRIGIDA POR MODELOS TECHNOLOGIES INTEGRATION IN A MODEL DRIVEN J2EE PLATFORM

    Directory of Open Access Journals (Sweden)

    David Colque C

    2006-12-01

    Full Text Available Este documento presenta una propuesta de cómo integrar adecuadamente diversas tecnologías de persistencia, de negocios y web en una plataforma J2EE. Esto involucra una arquitectura de múltiples capas, que considera para cada capa el uso de soluciones prácticas efectivas en el desarrollo de software, también se considera el uso del paradigma de desarrollo dirigido por modelos (MDA para facilitar su integración, implementado en el Framework Open Source AndroMDA, y el proceso de desarrollo propuesto por Larman. De este modo se pretende fortalecer el desarrollo orientado a objetos al incorporar una herramienta MDA que genera código a partir de los modelos de cada plataforma específica e incentivar el uso de modelos en el proceso de desarrollo del software, mejorando así la calidad del software, la portabilidad, la interoperabilidad y la reusabilidad, como también la independencia de las tecnologías usadas en cada capa.This work presents a proposal for integrating properly diverse technologies of persistence of business and Web in a J2EE platform. This involves an architecture of diverse layers, which considers the use of effective practical solutions for each layer in the development of the software. Also are considered the use of the Model Driven Architecture Paradigm, for facilitating integration performed in the Open Source AndroMDA Framework, and the development process proposed by Larman. This process is aimed at strengthening the development oriented to objects, when incorporating a MDA tool, which generates codes from the models of every specific platform; encouraging the use of models in the process of software development, improving the quality, the portability, the interoperability, as well as reusing the software, and also the self sufficiency of the technologies used in every layer.

  12. Research on the Integration Technologies of Aerospace Products Lean Assembly Platform%航天产品精益装配平台集成技术研究

    Institute of Scientific and Technical Information of China (English)

    黄鸣; 薛善良; 马继红; 李建平; 杨年宝

    2012-01-01

    It researches a technology of lean assembly platform integration base on Web service, reviews the engineering application of the lean production method in aerospace product process. On the basis of analyzing the situation of manufacture management for assembly integration, it designs a functional model of lean assembly platform, presents the basic data management, assembly process design management, just in time assembly management and so on. It builds a four - layer structure with the application of SOA, describes the client layer, operation layer, service layer and data layer, develops a supporting environment for the full implementation of Lean assembly.%以实施航天产品装配精益生产为工程应用背景,研究了基于Web Service的精益装配平台集成技术.基于对航天产品装配生产管理现状的讨论,分析了精益装配平台集成需求.设计了包括基础数据管理、装配工艺设计管理、准时装配管理等模块的精益装配平台功能模型.应用SOA设计思想,搭建了含有客户层、业务层、服务层和数据层的精益装配平台4层架构.讨论了精益装配平台实现技术,为航天产品精益装配的全面实施提供支撑环境.

  13. An integrated platform for directly widely-targeted quantitative analysis of feces part II: An application for steroids, eicosanoids, and porphyrins profiling.

    Science.gov (United States)

    Song, Yuelin; Song, Qingqing; Li, Jun; Zheng, Jiao; Li, Chun; Zhang, Yuan; Zhang, Lingling; Jiang, Yong; Tu, Pengfei

    2016-08-19

    Steroids, especially bile acids, along with eicosanoids and porphyrins in feces play pivotal roles for the clinical diagnosis of various diseases. However, their reliable measurement is extensively obstructed by poor stability, structural diversity, broad content ranges, and tedious sample preparation protocols that account for a majority of the measurement errors. In current study, in-depth component screening was initially carried out by flexibly integrating diverse modes, such as predefined multiple reaction monitoring, stepped multiple ion monitoring, neutral loss scan, and precursor ion scan on a hybrid triple quadrupole-linear ion trap mass spectrometer, which also provided MS(2) spectra via enhanced product ion experiments. Meanwhile, a hybrid ion trap-time of flight mass spectrometer served as a complementary tool by providing accurate mass spectral information. Afterwards, because authentic compounds were unavailable for most analytes, an online optimization strategy was then proposed to optimize parameters, including precursor-to-product ion transitions and spectrometric parameters, notably collision energy. Finally, direct analysis of all detected components in feces was carried out by employing a platform integrating online pressurized liquid extraction, turbulent flow chromatography, and LC-MS/MS, and applying those optimized parameters. Seventy-one compounds, including 52 steroids and 13 eicosanoids, together with 6 porphyrins, were found and annotated in a fecal pool, and then relatively quantified in various fecal matrices. The quantitative dataset was subjected for multivariate statistical analysis and significant differences were observed among the quantitative chemome profiles of the fecal matrices from different groups. The findings obtained in the two parts demonstrated that the analytical platform in combination with the work-flow is qualified for not only directly simultaneous measurement of diverse endogenous substances, but widely targeted

  14. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

    Science.gov (United States)

    Bielecka, Magdalena K.; Tezera, Liku B.; Zmijan, Robert; Drobniewski, Francis; Zhang, Xunli; Jayasinghe, Suwan

    2017-01-01

    ABSTRACT Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance. PMID:28174307

  15. A 3D porous polymer monolith-based platform integrated in poly(dimethylsiloxane) microchips for immunoassay.

    Science.gov (United States)

    Kang, Qin-Shu; Shen, Xiao-Fan; Hu, Na-Na; Hu, Meng-Jia; Liao, Hui; Wang, Han-Zhong; He, Zhi-Ke; Huang, Wei-Hua

    2013-05-01

    In this work, we demonstrate the immunocapture and on-line fluorescence immunoassay of protein and virus based on porous polymer monoliths (PPM) in microfluidic devices. Poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) [poly(GMA-co-EGDMA)] monoliths were successfully synthesized in the polydimethylsiloxane (PDMS) microfluidic channels by in situ UV-initiated free radical polymerization. After surface modification, PPM provides a high-surface area and specific affinity 3D substrate for immunoassays. Combining with well controlled microfluidic devices, the direct immunoassay of IgG and sandwich immunoassay of inactivated H1N1 influenza virus using 5 μL sample has been accomplished, with detection limits of 4 ng mL(-1) and less than 10 pg mL(-1), respectively. The enhanced detection sensitivity is due to both high surface area of PPM and flow-through design. The detection time was obviously decreased mainly due to the shortened diffusion distance and improved convective mass transfer inside the monolith, which accelerates the reaction kinetics between antigen and antibody. This work provides a novel microfluidic immunoassay platform with high efficiency thereby enabling fast and sensitive immunoassay.

  16. Integrated Observations From Fixed and AUV Platforms in the Littoral Zone at the SFOMC Coastal Ocean Observatory

    Science.gov (United States)

    Dhanak, M. R.

    2001-12-01

    A 12-hour survey of the coastal waters off the east coast of Florida at the South Florida Ocean Measurement Center (SFOMC) coastal ocean observatory, during summer 1999, is described to illustrate the observatory's capabilities for ocean observation. The facility is located close to the Gulf Stream, the continental shelf break being only 3 miles from shore and is therefore influenced by the Gulf Stream meanders and the instability of the horizontal shear layer at its edge. As a result, both cross-shelf and along-shelf components of currents in the littoral zone can undergo dramatic +/- 0.5 m/s oscillations. Observations of surface currents from an OSCR, and of subsurface structure from an autonomous underwater vehicle (AUV) platform, a bottom-mounted ADCP and CT-chain arrays during the survey will be described and compared. The AUV on-board sensors included upward and downward looking 1200kHz ADCP, a CTD package and a small-scale turbulence package, consisting of two shear probes and a fast-response thermistor. Prevailing atmospheric conditions were recorded at an on-site buoy. The combined observations depict flows over a range of scales. Acknowledgements: The observations from the OSCR are due to Nick Shay and Tom Cook (University of Miami), and from the bottom-mounted ADCP, CT chain arrays and the surface buoy are due to Alex Soloviev (Nova Southeastern University) and Mark Luther and Bob Weisberg (University of South Florida).

  17. Novel Ge waveguide platform on Ge-on-insulator wafer for mid-infrared photonic integrated circuits.

    Science.gov (United States)

    Kang, Jian; Takenaka, Mitsuru; Takagi, Shinichi

    2016-05-30

    We present Ge rib waveguide devices fabricated on a Ge-on-insulator (GeOI) wafer as a proof-of-concept Ge mid-infrared photonics platform. Numerical analysis revealed that the driving current for a given optical attenuation in a carrier-injection Ge waveguide device at a 1.95 μm wavelength can be approximately five times smaller than that in a Si device, enabling in-line carrier-injection Ge optical modulators based on free-carrier absorption. We prepared a GeOI wafer with a 2-μm-thick buried oxide layer (BOX) by wafer bonding. By using the GeOI wafer, we fabricated Ge rib waveguides. The Ge rib waveguides were transparent to 2 μm wavelengths and the propagation loss was found to be 1.4 dB/mm, which may have been caused by sidewall scattering. We achieved a negligible bend loss in the Ge rib waveguide, even with a 5 μm bend radius, owing to the strong optical confinement in the GeOI structure. We also formed a lateral p-i-n junction along the Ge rib waveguide to explore the capability of absorption modulation by carrier injection. By injecting current through the lateral p-i-n junction, we achieved optical intensity modulation in the 2 μm band based on the free-carrier absorption in Ge.

  18. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis.

    Science.gov (United States)

    Bielecka, Magdalena K; Tezera, Liku B; Zmijan, Robert; Drobniewski, Francis; Zhang, Xunli; Jayasinghe, Suwan; Elkington, Paul

    2017-02-07

    Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance.

  19. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

    Directory of Open Access Journals (Sweden)

    Magdalena K. Bielecka

    2017-02-01

    Full Text Available Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional culture or Middlebrook 7H9 broth, demonstrating that antibiotic sensitivity within microspheres reflects conditions in patients. We then performed pharmacokinetic modeling by combining the microsphere system with a microfluidic plate and demonstrated that we can model the effect of dynamic antibiotic concentrations on mycobacterial killing. The microsphere system is highly tractable, permitting variation of cell content, the extracellular matrix, sphere size, the infectious dose, and the surrounding medium with the potential to address a wide array of human infections and the threat of antimicrobial resistance.

  20. Advances in integrated and sustainable supply chain planning concepts, methods, tools and solution approaches toward a platform for industrial practice

    CERN Document Server

    Laínez-Aguirre, José Miguel

    2015-01-01

    Decision making at the enterprise level often encompass not only production operations and  product R&D, but other strategic functions such as financial planning and marketing. With the aim of maximizing growth and a firm’s value, companies often focus on co-ordinating these functional components as well as traditional hierarchical decision levels. Understanding this interplay can enhance enterprise capabilities of adaptation and response to uncertainties arising from internal processes as well as the external environment. This book presents concepts, methods, tools and solutions based on mathematical programming, which provides the quantitative support needed for integrated decision-making and ultimately for improving the allocation of overall corporate resources (e.g., materials, cash and personnel). Through a systems perspective, the integrated planning of the supply chain also promotes activities of reuse, reduction and recycling for achieving more sustainable environmental impacts of production/di...

  1. OncDRS: An integrative clinical and genomic data platform for enabling translational research and precision medicine

    Directory of Open Access Journals (Sweden)

    John Orechia

    2015-09-01

    Full Text Available We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS and a suite of tools called Oncology Data Retrieval Systems (OncDRS. OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has delivered data for more than 50 research studies.

  2. Quantification, challenges and outlook of PV integration in the power system: a review by the European PV Technology Platform

    DEFF Research Database (Denmark)

    Alet, Pierre-Jean; Baccaro, Federica; De Felice, Matteo;

    2015-01-01

    Integration in the power system has become a limiting factor to the further development of photovoltaics. Proper quantification is needed to evaluate both issues and solutions; the share of annual electricity demand is widely used but we found that some of the metrics which are related to power...... rather than energy better reflect the impact on networks. Barriers to wider deployment of PV into power grids can be split between local technical issues (voltage levels, harmonics distortion, reverse power flows and transformer loading) and system-wide issues (intermittency, reduction of system...... networks. Forecasting, storage, and combination with other renewable sources are interdependent solutions to solve the intermittency issue. Finally, we found that PV is also an opportunity to reduce some investment required to upgrade existing power networks. Through integration with micro-grids and hybrid...

  3. Quantification, challenges and outlook of PV integration in the power system: a review by the European PV Technology Platform

    DEFF Research Database (Denmark)

    Alet, Pierre-Jean; Baccaro, Federica; De Felice, Matteo;

    2015-01-01

    rather than energy better reflect the impact on networks. Barriers to wider deployment of PV into power grids can be split between local technical issues (voltage levels, harmonics distortion, reverse power flows and transformer loading) and system-wide issues (intermittency, reduction of system......Integration in the power system has become a limiting factor to the further development of photovoltaics. Proper quantification is needed to evaluate both issues and solutions; the share of annual electricity demand is widely used but we found that some of the metrics which are related to power...... networks. Forecasting, storage, and combination with other renewable sources are interdependent solutions to solve the intermittency issue. Finally, we found that PV is also an opportunity to reduce some investment required to upgrade existing power networks. Through integration with micro-grids and hybrid...

  4. De novo genome assembly of the economically important weed horseweed using integrated data from multiple sequencing platforms.

    Science.gov (United States)

    Peng, Yanhui; Lai, Zhao; Lane, Thomas; Nageswara-Rao, Madhugiri; Okada, Miki; Jasieniuk, Marie; O'Geen, Henriette; Kim, Ryan W; Sammons, R Douglas; Rieseberg, Loren H; Stewart, C Neal

    2014-11-01

    Horseweed (Conyza canadensis), a member of the Compositae (Asteraceae) family, was the first broadleaf weed to evolve resistance to glyphosate. Horseweed, one of the most problematic weeds in the world, is a true diploid (2n = 2x = 18), with the smallest genome of any known agricultural weed (335 Mb). Thus, it is an appropriate candidate to help us understand the genetic and genomic bases of weediness. We undertook a draft de novo genome assembly of horseweed by combining data from multiple sequencing platforms (454 GS-FLX, Illumina HiSeq 2000, and PacBio RS) using various libraries with different insertion sizes (approximately 350 bp, 600 bp, 3 kb, and 10 kb) of a Tennessee-accessed, glyphosate-resistant horseweed biotype. From 116.3 Gb (approximately 350× coverage) of data, the genome was assembled into 13,966 scaffolds with 50% of the assembly = 33,561 bp. The assembly covered 92.3% of the genome, including the complete chloroplast genome (approximately 153 kb) and a nearly complete mitochondrial genome (approximately 450 kb in 120 scaffolds). The nuclear genome is composed of 44,592 protein-coding genes. Genome resequencing of seven additional horseweed biotypes was performed. These sequence data were assembled and used to analyze genome variation. Simple sequence repeat and single-nucleotide polymorphisms were surveyed. Genomic patterns were detected that associated with glyphosate-resistant or -susceptible biotypes. The draft genome will be useful to better understand weediness and the evolution of herbicide resistance and to devise new management strategies. The genome will also be useful as another reference genome in the Compositae. To our knowledge, this article represents the first published draft genome of an agricultural weed.

  5. On-chip hybrid photonic-plasmonic light concentrator for nanofocusing in an integrated silicon photonics platform.

    Science.gov (United States)

    Luo, Ye; Chamanzar, Maysamreza; Apuzzo, Aniello; Salas-Montiel, Rafael; Nguyen, Kim Ngoc; Blaize, Sylvain; Adibi, Ali

    2015-02-11

    The enhancement and confinement of electromagnetic radiation to nanometer scale have improved the performances and decreased the dimensions of optical sources and detectors for several applications including spectroscopy, medical applications, and quantum information. Realization of on-chip nanofocusing devices compatible with silicon photonics platform adds a key functionality and provides opportunities for sensing, trapping, on-chip signal processing, and communications. Here, we discuss the design, fabrication, and experimental demonstration of light nanofocusing in a hybrid plasmonic-photonic nanotaper structure. We discuss the physical mechanisms behind the operation of this device, the coupling mechanisms, and how to engineer the energy transfer from a propagating guided mode to a trapped plasmonic mode at the apex of the plasmonic nanotaper with minimal radiation loss. Optical near-field measurements and Fourier modal analysis carried out using a near-field scanning optical microscope (NSOM) show a tight nanofocusing of light in this structure to an extremely small spot of 0.00563(λ/(2n(rmax)))(3) confined in 3D and an exquisite power input conversion of 92%. Our experiments also verify the mode selectivity of the device (low transmission of a TM-like input mode and high transmission of a TE-like input mode). A large field concentration factor (FCF) of about 4.9 is estimated from our NSOM measurement with a radius of curvature of about 20 nm at the apex of the nanotaper. The agreement between our theory and experimental results reveals helpful insights about the operation mechanism of the device, the interplay of the modes, and the gradual power transfer to the nanotaper apex.

  6. National Community Solar Platform

    Energy Technology Data Exchange (ETDEWEB)

    Rupert, Bart [Clean Energy Collective, Louisville, CO (United States)

    2016-06-30

    This project was created to provide a National Community Solar Platform (NCSP) portal known as Community Solar Hub, that is available to any entity or individual who wants to develop community solar. This has been done by providing a comprehensive portal to make CEC’s solutions, and other proven community solar solutions, externally available for everyone to access – making the process easy through proven platforms to protect subscribers, developers and utilities. The successful completion of this project provides these tools via a web platform and integration APIs, a wide spectrum of community solar projects included in the platform, multiple groups of customers (utilities, EPCs, and advocates) using the platform to develop community solar, and open access to anyone interested in community solar. CEC’s Incubator project includes web-based informational resources, integrated systems for project information and billing systems, and engagement with customers and users by community solar experts. The combined effort externalizes much of Clean Energy Collective’s industry-leading expertise, allowing third parties to develop community solar without duplicating expensive start-up efforts. The availability of this platform creates community solar projects that are cheaper to build and cheaper to participate in, furthering the goals of DOE’s SunShot Initiative. Final SF 425 Final SF 428 Final DOE F 2050.11 Final Report Narrative

  7. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

    Science.gov (United States)

    Oprea, Tudor I; Nielsen, Sonny Kim; Ursu, Oleg; Yang, Jeremy J; Taboureau, Olivier; Mathias, Stephen L; Kouskoumvekaki, Lrene; Sklar, Larry A; Bologa, Cristian G

    2011-03-14

    Finding new uses for old drugs is a strategy embraced by the pharmaceutical industry, with increasing participation from the academic sector. Drug repurposing efforts focus on identifying novel modes of action, but not in a systematic manner. With intensive data mining and curation, we aim to apply bio- and cheminformatics tools using the DRUGS database, containing 3,837 unique small molecules annotated on 1,750 proteins. These are likely to serve as drug targets and antitargets (i.e., associated with side effects, SE). The academic community, the pharmaceutical sector and clinicians alike could benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based on 7,684 approved drug labels, ADL (Dailymed) via text mining. From the ADL corresponding to 988 unique drugs, the "adverse reactions" section was mapped onto 174 SE, then clustered via principal component analysis into a 5x5 self-organizing map that was integrated into a Cytoscape network of SE-D-T-CO. This type of data can be used to streamline drug repurposing and may result in novel insights that can lead to the identification of novel drug actions.

  8. Application of Cloud Computing in the Intelligent Medical Integration Platform%云计算在智慧医疗集成平台中的应用

    Institute of Scientific and Technical Information of China (English)

    王琳华

    2014-01-01

    Digital hospital information integration requires fusion of medical information of a variety of intelligent devices, and professional medical services facing to regional healthcare and users. Using cloud computing technology, through the server virtualization, the data collection is realized. This method is high-efficiency, easy to maintain and easy to manage. The information security is improved. Cloud computing technology can solve the problems of intelligent healthcare integration platform, such as high operational cost and big information security risks. Mobile medical healthcare is realized, and it can better promote the development of intelligent healthcare.%数字化医院信息集成需要融合多种智能设备医疗信息,提供面向区域医疗及用户的专业化医疗服务。利用云计算技术,通过服务器虚拟化来实现数据的集合,这种方式高效,易维护,易管理,全面提升信息安全。云计算技术能够解决智慧医疗集成平台中运维成本高,信息安全风险大等问题,实现移动医疗,更好地促进智慧医疗的发展。

  9. Integrated TLWP-FPSO (Tension Leg Wellhead Platform-Floating Production, Storage and Offloading Vessel) solution for deep water field development offshore Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Neil; Heidari, Homayoun; Large, Sean [SBM Atlantia, Houston, TX (United States)

    2008-07-01

    A development strategy for some deep water fields offshore Brazil consists of a TLWP (Tension-Leg Wellhead Platform) connected by a fluid transfer line to a nearby FPSO. The TLWP provides dry tree riser support, drilling capability, manifolding, test separation, and multiphase pumping, while all other functions including full processing, accommodations, gas compression, power generation, water and chemical injection, storage and offloading, and gas export are provided by the FPSO. In one such scenario, the TLWP and FPSO could be connected using SBM's GAP mid-water fluid transfer line technology, with SBM Atlantia's FourStar{sup TM} hull concept for the TLWP. The FourStar{sup TM} is designed to be quayside- or float over-integrable, thus eliminating the need for a heavy lift installation vessel; while being structurally and hydrodynamically superior to other TLP alternatives. This paper presents a description of the technical development of the FourStar{sup TM} TLP and an overview of the GAP technology, and discusses the characteristics of an integrated TLWP-GAP-FPSO field development solution for a typical application offshore Brazil (author)

  10. Label-free Detection of Influenza Viruses using a Reduced Graphene Oxide-based Electrochemical Immunosensor Integrated with a Microfluidic Platform

    Science.gov (United States)

    Singh, Renu; Hong, Seongkyeol; Jang, Jaesung

    2017-02-01

    Reduced graphene oxide (RGO) has recently gained considerable attention for use in electrochemical biosensing applications due to its outstanding conducting properties and large surface area. This report presents a novel microfluidic chip integrated with an RGO-based electrochemical immunosensor for label-free detection of an influenza virus, H1N1. Three microelectrodes were fabricated on a glass substrate using the photolithographic technique, and the working electrode was functionalized using RGO and monoclonal antibodies specific to the virus. These chips were integrated with polydimethylsiloxane microchannels. Structural and morphological characterizations were performed using X-ray photoelectron spectroscopy and scanning electron microscopy. Electrochemical studies revealed good selectivity and an enhanced detection limit of 0.5 PFU mL‑1, where the chronoamperometric current increased linearly with H1N1 virus concentration within the range of 1 to 104 PFU mL‑1 (R2 = 0.99). This microfluidic immunosensor can provide a promising platform for effective detection of biomolecules using minute samples.

  11. Label-free Detection of Influenza Viruses using a Reduced Graphene Oxide-based Electrochemical Immunosensor Integrated with a Microfluidic Platform

    Science.gov (United States)

    Singh, Renu; Hong, Seongkyeol; Jang, Jaesung

    2017-01-01

    Reduced graphene oxide (RGO) has recently gained considerable attention for use in electrochemical biosensing applications due to its outstanding conducting properties and large surface area. This report presents a novel microfluidic chip integrated with an RGO-based electrochemical immunosensor for label-free detection of an influenza virus, H1N1. Three microelectrodes were fabricated on a glass substrate using the photolithographic technique, and the working electrode was functionalized using RGO and monoclonal antibodies specific to the virus. These chips were integrated with polydimethylsiloxane microchannels. Structural and morphological characterizations were performed using X-ray photoelectron spectroscopy and scanning electron microscopy. Electrochemical studies revealed good selectivity and an enhanced detection limit of 0.5 PFU mL−1, where the chronoamperometric current increased linearly with H1N1 virus concentration within the range of 1 to 104 PFU mL−1 (R2 = 0.99). This microfluidic immunosensor can provide a promising platform for effective detection of biomolecules using minute samples. PMID:28198459

  12. OMIA (Online Mendelian Inheritance in Animals): an enhanced platform and integration into the Entrez search interface at NCBI.

    Science.gov (United States)

    Lenffer, Johann; Nicholas, Frank W; Castle, Kao; Rao, Arjun; Gregory, Stefan; Poidinger, Michael; Mailman, Matthew D; Ranganathan, Shoba

    2006-01-01

    Online Mendelian Inheritance in Animals (OMIA) is a comprehensive, annotated catalogue of inherited disorders and other familial traits in animals other than humans and mice. Structured as a comparative biology resource, OMIA is a comprehensive resource of phenotypic information on heritable animal traits and genes in a strongly comparative context, relating traits to genes where possible. OMIA is modelled on and is complementary to Online Mendelian Inheritance in Man (OMIM). OMIA has been moved to a MySQL database at the Australian National Genomic Information Service (ANGIS) and can be accessed at http://omia.angis.org.au/. It has also been integrated into the Entrez search interface at the National Center for Biotechnology Information (NCBI; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=omia). Curation of OMIA data by researchers working on particular species and disorders has also been enabled.

  13. Hierarchical DSE for multi-ASIP platforms

    DEFF Research Database (Denmark)

    Micconi, Laura; Corvino, Rosilde; Gangadharan, Deepak;

    2013-01-01

    This work proposes a hierarchical Design Space Exploration (DSE) for the design of multi-processor platforms targeted to specific applications with strict timing and area constraints. In particular, it considers platforms integrating multiple Application Specific Instruction Set Processors (ASIPs...

  14. Universal visualization platform

    Science.gov (United States)

    Gee, Alexander G.; Li, Hongli; Yu, Min; Smrtic, Mary Beth; Cvek, Urska; Goodell, Howie; Gupta, Vivek; Lawrence, Christine; Zhou, Jainping; Chiang, Chih-Hung; Grinstein, Georges G.

    2005-03-01

    Although there are a number of visualization systems to choose from when analyzing data, only a few of these allow for the integration of other visualization and analysis techniques. There are even fewer visualization toolkits and frameworks from which one can develop ones own visualization applications. Even within the research community, scientists either use what they can from the available tools or start from scratch to define a program in which they are able to develop new or modified visualization techniques and analysis algorithms. Presented here is a new general-purpose platform for constructing numerous visualization and analysis applications. The focus of this system is the design and experimentation of new techniques, and where the sharing of and integration with other tools becomes second nature. Moreover, this platform supports multiple large data sets, and the recording and visualizing of user sessions. Here we introduce the Universal Visualization Platform (UVP) as a modern data visualization and analysis system.

  15. An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework.

    Science.gov (United States)

    Chen, Yi-An; Tripathi, Lokesh P; Mizuguchi, Kenji

    2016-01-01

    Data analysis is one of the most critical and challenging steps in drug discovery and disease biology. A user-friendly resource to visualize and analyse high-throughput data provides a powerful medium for both experimental and computational biologists to understand vastly different biological data types and obtain a concise, simplified and meaningful output for better knowledge discovery. We have previously developed TargetMine, an integrated data warehouse optimized for target prioritization. Here we describe how upgraded and newly modelled data types in TargetMine can now survey the wider biological and chemical data space, relevant to drug discovery and development. To enhance the scope of TargetMine from target prioritization to broad-based knowledge discovery, we have also developed a new auxiliary toolkit to assist with data analysis and visualization in TargetMine. This toolkit features interactive data analysis tools to query and analyse the biological data compiled within the TargetMine data warehouse. The enhanced system enables users to discover new hypotheses interactively by performing complicated searches with no programming and obtaining the results in an easy to comprehend output format. Database URL: http://targetmine.mizuguchilab.org.

  16. Plants in silico: why, why now and what?--an integrative platform for plant systems biology research.

    Science.gov (United States)

    Zhu, Xin-Guang; Lynch, Jonathan P; LeBauer, David S; Millar, Andrew J; Stitt, Mark; Long, Stephen P

    2016-05-01

    A paradigm shift is needed and timely in moving plant modelling from largely isolated efforts to a connected community endeavour that can take full advantage of advances in computer science and in mechanistic understanding of plant processes. Plants in silico (Psi) envisions a digital representation of layered dynamic modules, linking from gene networks and metabolic pathways through to cellular organization, tissue, organ and whole plant development, together with resource capture and use efficiency in dynamic competitive environments, ultimately allowing a mechanistically rich simulation of the plant or of a community of plants in silico. The concept is to integrate models or modules from different layers of organization spanning from genome to phenome to ecosystem in a modular framework allowing the use of modules of varying mechanistic detail representing the same biological process. Developments in high-performance computing, functional knowledge of plants, the internet and open-source version controlled software make achieving the concept realistic. Open source will enhance collaboration and move towards testing and consensus on quantitative theoretical frameworks. Importantly, Psi provides a quantitative knowledge framework where the implications of a discovery at one level, for example, single gene function or developmental response, can be examined at the whole plant or even crop and natural ecosystem levels.

  17. Design of an Integrated Sensor Platform for Vital Sign Monitoring of Newborn Infants at Neonatal Intensive Care Units

    Directory of Open Access Journals (Sweden)

    Wei Chen

    2010-01-01

    Full Text Available Continuous health status monitoring and advances in medical treatments have resulted in a significant increase of survival rate in critically ill infants admitted into Neonatal Intensive Care Units (NICUs. The quality of life and long-term health prospects of the neonates depend increasingly on the reliability and comfort of the monitoring systems. In this paper, we present the design work of a smart jacket for vital sign monitoring of neonates at a NICU. The design represents a unique integration of sensor technology, user focus and design aspects. Textile sensors, a reflectance pulse oximeter and a wearable temperature sensor were proposed to be embedded into the smart jacket. Location of the sensor, materials and appearance were designed to optimize the functionality, patient comfort and the possibilities for aesthetic features. Prototypes were built for demonstrating the design concept and experimental results were obtained from tests on premature babies at the NICU of M�xima Medical Centre (MMC in Veldhoven, the Netherlands.

  18. Ocean thermal energy conversion (OTEC) platform configuration and integration. Final report. Volume I. Systems requirements and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    Studies leading to the development of two 400 MW Offshore Thermal Energy Conversion Commercial Plants are presented. This volume includes a summary of three tasks: task IIA--systems evaluation and requirements; task IIB--evaluation plan; task III--technology review; and task IV--systems integration evaluation. Task IIA includes the definition of top level requirements and an assessment of factors critical to the selection of hull configuration and size, quantification of payload requirements and characteristics, and sensitivity of system characteristics to site selection. Task IIB includes development of a methodology for systematically evaluating the candidate hullforms, based on interrelationships and priorities developed during task IIA. Task III includes the assessment of current technology and identification of deficiencies in relation to OTEC requirements and the development of plans to correct such deficiencies. Task IV involves the formal evaluation of the six candidate hullforms in relation to sit and plant capacity to quantify cost/size/capability relationships, leading to selection of an optimum commercial plant. (WHK)

  19. Microalgal-biotechnology as a platform for an integral biogas upgrading and nutrient removal from anaerobic effluents.

    Science.gov (United States)

    Bahr, Melanie; Díaz, Ignacio; Dominguez, Antonio; González Sánchez, Armando; Muñoz, Raul

    2014-01-01

    The potential of a pilot high rate algal pond (HRAP) interconnected via liquid recirculation with an external absorption column for the simultaneous removal of H2S and CO2 from biogas using an alkaliphilic microalgal-bacterial consortium was evaluated. A bubble column was preferred as external absorption unit to a packed bed column based on its ease of operation, despite showing a comparable CO2 mass transfer capacity. When the combined HRAP-bubble column system was operated under continuous mode with mineral salt medium at a biogas residence time of 30 min in the absorption column, the system removed 100% of the H2S (up to 5000 ppmv) and 90% of the CO2 supplied, with O2 concentrations in the upgraded biogas below 0.2%. The use of diluted centrates as a free nutrient source resulted in a gradual decrease in CO2 removal to steady values of 40%, while H2S removal remained at 100%. The anaerobic digestion of the algal-bacterial biomass produced during biogas upgrading resulted in a CH4 yield of 0.21-0.27 L/gVS, which could satisfy up to 60% of the overall energy demand for biogas upgrading. This proof of concept study confirmed that algal-bacterial photobioreactors can support an integral upgrading without biogas contamination, with a net negative CO2 footprint, energy production, and a reduction of the eutrophication potential of the residual anaerobic effluents.

  20. The Perigeo Project: Inertial and Imaging Sensors Processing, Integration and Validation on Uav Platforms for Space Navigation

    Science.gov (United States)

    Molina, P.; Angelats, E.; Colomina, I.; Latorre, A.; Montaño, J.; Wis, M.

    2014-03-01

    The PERIGEO R&D project aims at developing, testing and validating algorithms and/or methods for space missions in various field of research. This paper focuses in one of the scenarios considered in PERIGEO: navigation for atmospheric flights. Space missions heavily rely on navigation to reach success, and autonomy of on-board navigation systems and sensors is desired to reach new frontiers of space exploration. From the technology side, optical frame cameras, LiDAR and inertial technologies are selected to cover the requirements of such missions. From the processing side, image processing techniques are developed for vision-based relative and absolute navigation, based on point extraction and matching from camera images, and crater detection and matching in camera and LiDAR images. The current paper addresses the challenges of space navigation, presents the current developments and preliminary results, and describes payload elements to be integrated in an Unmanned Aerial Vehicle (UAV) for in-flight testing of systems and algorithms. Again, UAVs are key enablers of scientific capabilities, in this case, to bridge the gap between laboratory simulation and expensive, real space missions.

  1. THE PERIGEO PROJECT: INERTIAL AND IMAGING SENSORS PROCESSING, INTEGRATION AND VALIDATION ON UAV PLATFORMS FOR SPACE NAVIGATION

    Directory of Open Access Journals (Sweden)

    P. Molina

    2014-03-01

    Full Text Available The PERIGEO R&D project aims at developing, testing and validating algorithms and/or methods for space missions in various field of research. This paper focuses in one of the scenarios considered in PERIGEO: navigation for atmospheric flights. Space missions heavily rely on navigation to reach success, and autonomy of on-board navigation systems and sensors is desired to reach new frontiers of space exploration. From the technology side, optical frame cameras, LiDAR and inertial technologies are selected to cover the requirements of such missions. From the processing side, image processing techniques are developed for vision-based relative and absolute navigation, based on point extraction and matching from camera images, and crater detection and matching in camera and LiDAR images. The current paper addresses the challenges of space navigation, presents the current developments and preliminary results, and describes payload elements to be integrated in an Unmanned Aerial Vehicle (UAV for in-flight testing of systems and algorithms. Again, UAVs are key enablers of scientific capabilities, in this case, to bridge the gap between laboratory simulation and expensive, real space missions.

  2. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  3. Solid-state probe based electrochemical aptasensor for cocaine: a potentially convenient, sensitive, repeatable, and integrated sensing platform for drugs.

    Science.gov (United States)

    Du, Yan; Chen, Chaogui; Yin, Jianyuan; Li, Bingling; Zhou, Ming; Dong, Shaojun; Wang, Erkang

    2010-02-15

    Aptamers, which are artificial oligonucleotides selected in vitro, have been employed to design novel biosensors (i.e., aptasensors). In this work, we first constructed a label-free electrochemical aptasensor introducing a probe immobilization technique by the use of a layer-by-layer (LBL) self-assembled multilayer with ferrocene-appended poly(ethyleneimine) (Fc-PEI) on an indium tin oxide (ITO) array electrode for detection of cocaine. The Fc-PEI and gold nanoparticles (AuNPs) were LBL assembled on the electrode surface via electrostatic interaction. Then, cocaine aptamer fragments, SH-C2, were covalently labeled onto the outermost AuNP layer. When the target cocaine and cocaine aptamer C1 were present simultaneously, the SH-C2 layer hybridized partly with C1 to bind the cocaine, which led to a decreased differential pulse voltammetry (DPV) signal of Fc-PEI. This DPV signal change could be used to sensitively detect cocaine with the lowest detectable concentration down to 0.1 microM and the detection range up to 38.8 microM, which falls in the the expected range for medical use of detecting drug abuse involving cocaine. Meanwhile, the sensor was specific to cocaine in complex biologic fluids such as human plasma, human saliva, etc. The sensing strategy had general applicability, and the detection of thrombin could also be realized, displayed a low detection limit, and exhibited worthiness to other analytes. The aptasensor based on the array electrode held promising potential for integration of the sensing ability in multianalysis for simultaneous detection.

  4. 基于SOA架构的农村信息资源集成平台设计%Design of Rural Information Resource Integration Platform Based on SOA

    Institute of Scientific and Technical Information of China (English)

    段延娥

    2012-01-01

    The rural informatization refers to the widespread application and promotion of communication technology and computer technology in rural production, life and social management, and is a very important part of social informatization. The information resource construction as the core content of rural informatization construction, has the direct impact on the level of rural informatization construction. On the basis of sufficient analyzing the current situation of our country rural information resources construction, the existing problems of the rural information resources construction were discussed in detail, and the concept, basic theory and implementation technique of service-oriented architecture (SOA) aredescribed. Using the designing theory of SOA, a comprehensive information resource integration platform based on SOA was presented, and the basic principle and model of design, and SSO design of the integration platform was discussed in details.%农村信息化是指通讯技术和计算机技术在农村生产、生活和社会管理中实现普遍应用和推广的过程,是社会信息化的重要组成部分。农村信息资源建设作为农村信息化建设的核心内容,直接影响着农村信息化建设的水平。在充分分析我国农村信息资源建设现状和发展瓶颈的基础上,详细探讨了农村信息资源建设中存在的问题,阐述了面向服务的体系架构SOA的基本内涵、工作原理、实现技术。利用面向服务架构的设计思想,提出了基于SOA架构的农村信息资源集成平台建设,重点讨论了集成平台的设计原则、设计模型及SSO安全性设计。

  5. Research and Design of Medical Data Integration Platform%医疗数据集成平台的研究与设计

    Institute of Scientific and Technical Information of China (English)

    胡芳; 沈绍武

    2015-01-01

    In this paper, through in-depth study on characteristics of hospital information system (HIS) construction and requirements of medical data integration, and combined with the medical data straits of heterogeneity, multi-source, complexity, dynamic growth, etc., the problem of information exchange in different systems was aimed to solved, in order to realize medical data sharing among internal systems in hospital.Based on Extensible Markup Language (XML), public data model was described by XML Schema technology. Global and local medical data were queried using XQuery technology. The results showed that a medical data integration platform based on HL7 standard and the middleware technologies were proposed. It was concluded that the platform shielded the heterogeneity of underlying medical data by middleware technology. It finally realized the global query and transparent access of medical data in HIS for users.%目的:本文通过深入分析医院信息系统建设的特点和医疗数据集成的需求,结合医疗数据的异构多源、庞大复杂、动态增长等特点,旨在解决医院各个系统之间的信息互通,实现医院内部系统之间的数据共享.方法:该集成平台以XML技术为基础,采用XML Schema技术来描述集成平台的公共数据模型;利用统一查询语言XQuery进行全局和局部医疗数据查询.结果:提出了一种以HL7标准为基础的基于中间件技术的医疗数据集成平台架构.结论:该平台利用中间件屏蔽底层医疗数据的异构性,最终实现用户对全院医疗数据的全局查询和透明访问.

  6. Design of photonic phased array switches using nano electromechanical systems on silicon-on-insulator integration platform

    Science.gov (United States)

    Hussein, Ali Abdulsattar

    This thesis presents an introduction to the design and simulation of a novel class of integrated photonic phased array switch elements. The main objective is to use nano-electromechanical (NEMS) based phase shifters of cascaded under-etched slot nanowires that are compact in size and require a small amount of power to operate them. The structure of the switch elements is organized such that it brings the phase shifting elements to the exterior sides of the photonic circuits. The transition slot couplers, used to interconnect the phase shifters, are designed to enable biasing one of the silicon beams of each phase shifter from an electrode located at the side of the phase shifter. The other silicon beam of each phase shifter is biased through the rest of the silicon structure of the switch element, which is taken as a ground. Phased array switch elements ranging from 2x2 up to 8x8 multiple-inputs/multiple-outputs (MIMO) are conveniently designed within reasonable footprints native to the current fabrication technologies. Chapter one presents the general layout of the various designs of the switch elements and demonstrates their novel features. This demonstration will show how waveguide disturbances in the interconnecting network from conventional switch elements can be avoided by adopting an innovative design. Some possible applications for the designed switch elements of different sizes and topologies are indicated throughout the chapter. Chapter two presents the design of the multimode interference (MMI) couplers used in the switch elements as splitters, combiners and waveguide crossovers. Simulation data and design methodologies for the multimode couplers of interest are detailed in this chapter. Chapter three presents the design and analysis of the NEMS-operated phase shifters. Both simulations and numerical analysis are utilized in the design of a 0°-180° capable NEMS-operated phase shifter. Additionally, the response of some of the designed photonic phased

  7. Construction of a Practice Teaching Platform by the Integration of Government, Production, Training, Research and Application%校政企互动构建“政产学研用”实践教育平台

    Institute of Scientific and Technical Information of China (English)

    代显华

    2013-01-01

    基于“卓越计划”对本科实践教学提出的新要求,理清实践教育平台构建思路,以基础实践、专业实践、行业综合实践平台,创新创业实践平台和国际合作教育实践平台构建“政产学研用”实践平台,通过完善“校政企”合作机制和实践教学系列改革措施,取得较好的实践效果和良好的社会回报.%The traditional training pattern in practice education is challenged by the "undergraduate excellent engineer training program".In this paper,the construction of a practice teaching platform was introduced which includes a basic platform,a professional practice platform,an industry comprehensive practice platform,an innovation practice platform and an international cooperative education platform,by the integration of government,production,training,research and application.Practice indicates that better practical effect and good social returns are obtained by the improvement of the cooperation between the government,the university and the enterprise,and by the reform of a series of practice teaching measures.

  8. Platform contents

    OpenAIRE

    Renault, Régis

    2014-01-01

    A monopoly platform hosts advertisers who compete on a market for horizontally differentiated products. These products may be either mass market products that appeal broadly to the entire consumer population or niche products that are tailored to the tastes of some particular group. Consumers search sequentially through ads incurring a surfing cost of moving to the next ad. They may click on an ad at some cost, which provides all relevant information and the opportunity to buy. The platform c...

  9. [Lens platform].

    Science.gov (United States)

    Łukaszewska-Smyk, Agnieszka; Kałuzny, Józef

    2010-01-01

    The lens platform defines lens structure and lens material. Evolution of lens comprises change in their shape, angulation of haptens and transition of three-piece lens into one-piece lens. The lens fall into two categories: rigid (PMMA) and soft (siliconic, acrylic, colameric). The main lens maaterials are polymers (hydrophilic and hydrophobic). The lens platform has an effect on biocompatibility, bioadhesion, stability of lens in capsule, degree of PCO evolution and sensitiveness to laser damages.

  10. Structure and genetic mechanisms of the Precambrian rifts of the East-European Platform in Russia by integrated study of seismic, gravity, and magnetic data

    Science.gov (United States)

    Kostyuchenko, S. L.; Egorkin, A. V.; Solodilov, L. N.

    1999-11-01

    Integrated models of the deep structure and origin of rifts located within the Russian portion of the East-European Platform have been developed from recent DSS results, new gravity and magnetic modelling, and geological and older geophysical data acquired over the last 50 years. The Mezen rift province, the Middle-Russian rift, the Valday rift, the Pachelma rift, and the rifts within the Pre-Caspian depression were studied. All of these rifts were affected by extension and filled with syn-rift sediments at different times through the Riphean (1650-650 Ma). Post-rift sedimentary basins developed from the end of the Neoproterozoic until the Cenozoic. The models indicate that the crustal structure and genesis of the individual rifts are different. The Mezen rift province was formed under a condition of limited extension of the continental crust. The McKenzie pure strain mechanism is acceptable for lithosphere extension in the Middle-Russian rift. The Wernicke model best expresses the Valday and Pachelma rifts. The rift process in the Pre-Caspian area is explained in terms of large-scale sliding apart of lithospheric plates, and approached the stage of development of oceanic crust.

  11. Centrifugal LabTube platform for fully automated DNA purification and LAMP amplification based on an integrated, low-cost heating system.

    Science.gov (United States)

    Hoehl, Melanie M; Weißert, Michael; Dannenberg, Arne; Nesch, Thomas; Paust, Nils; von Stetten, Felix; Zengerle, Roland; Slocum, Alexander H; Steigert, Juergen

    2014-06-01

    This paper introduces a disposable battery-driven heating system for loop-mediated isothermal DNA amplification (LAMP) inside a centrifugally-driven DNA purification platform (LabTube). We demonstrate LabTube-based fully automated DNA purification of as low as 100 cell-equivalents of verotoxin-producing Escherichia coli (VTEC) in water, milk and apple juice in a laboratory centrifuge, followed by integrated and automated LAMP amplification with a reduction of hands-on time from 45 to 1 min. The heating system consists of two parallel SMD thick film resistors and a NTC as heating and temperature sensing elements. They are driven by a 3 V battery and controlled by a microcontroller. The LAMP reagents are stored in the elution chamber and the amplification starts immediately after the eluate is purged into the chamber. The LabTube, including a microcontroller-based heating system, demonstrates contamination-free and automated sample-to-answer nucleic acid testing within a laboratory centrifuge. The heating system can be easily parallelized within one LabTube and it is deployable for a variety of heating and electrical applications.

  12. Tutorial: Digital microfluidic biochips: Towards hardware/software co-design and cyber-physical system integration

    DEFF Research Database (Denmark)

    Ho, Tsung-Yi; Huang, Juinn-Dar; Pop, Paul

    2013-01-01

    operations to functional units, and the layout and droplet-flow paths for the biochip. The role of the digital microfluidic platform as a “programmable and reconfigurable processor” for biochemical applications will be highlighted. Cyber-physical integration using low-cost sensors and adaptive control...

  13. Linking human health and livestock health: a "one-health" platform for integrated analysis of human health, livestock health, and economic welfare in livestock dependent communities.

    Directory of Open Access Journals (Sweden)

    S M Thumbi

    Full Text Available For most rural households in sub-Saharan Africa, healthy livestock play a key role in averting the burden associated with zoonotic diseases, and in meeting household nutritional and socio-economic needs. However, there is limited understanding of the complex nutritional, socio-economic, and zoonotic pathways that link livestock health to human health and welfare. Here we describe a platform for integrated human health, animal health and economic welfare analysis designed to address this challenge. We provide baseline epidemiological data on disease syndromes in humans and the animals they keep, and provide examples of relationships between human health, animal health and household socio-economic status.We designed a study to obtain syndromic disease data in animals along with economic and behavioral information for 1500 rural households in Western Kenya already participating in a human syndromic disease surveillance study. Data collection started in February 2013, and each household is visited bi-weekly and data on four human syndromes (fever, jaundice, diarrhea and respiratory illness and nine animal syndromes (death, respiratory, reproductive, musculoskeletal, nervous, urogenital, digestive, udder disorders, and skin disorders in cattle, sheep, goats and chickens are collected. Additionally, data from a comprehensive socio-economic survey is collected every 3 months in each of the study households.Data from the first year of study showed 93% of the households owned at least one form of livestock (55%, 19%, 41% and 88% own cattle, sheep, goats and chickens respectively. Digestive disorders, mainly diarrhea episodes, were the most common syndromes observed in cattle, goats and sheep, accounting for 56% of all livestock syndromes, followed by respiratory illnesses (18%. In humans, respiratory illnesses accounted for 54% of all illnesses reported, followed by acute febrile illnesses (40% and diarrhea illnesses (5%. While controlling for household

  14. GITEWS, an extensible and open integration platform for manifold sensor systems and processing components based on Sensor Web Enablement and the principles of Service Oriented Architectures

    Science.gov (United States)

    Haener, Rainer; Waechter, Joachim; Fleischer, Jens; Herrnkind, Stefan; Schwarting, Herrmann

    2010-05-01

    The German Indonesian Tsunami Early Warning System (GITEWS) is a multifaceted system consisting of various sensor types like seismometers, sea level sensors or GPS stations, and processing components, all with their own system behavior and proprietary data structure. To operate a warning chain, beginning from measurements scaling up to warning products, all components have to interact in a correct way, both syntactically and semantically. Designing the system great emphasis was laid on conformity to the Sensor Web Enablement (SWE) specification by the Open Geospatial Consortium (OGC). The technical infrastructure, the so called Tsunami Service Bus (TSB) follows the blueprint of Service Oriented Architectures (SOA). The TSB is an integration concept (SWE) where functionality (observe, task, notify, alert, and process) is grouped around business processes (Monitoring, Decision Support, Sensor Management) and packaged as interoperable services (SAS, SOS, SPS, WNS). The benefits of using a flexible architecture together with SWE lead to an open integration platform: • accessing and controlling heterogeneous sensors in a uniform way (Functional Integration) • assigns functionality to distinct services (Separation of Concerns) • allows resilient relationship between systems (Loose Coupling) • integrates services so that they can be accessed from everywhere (Location Transparency) • enables infrastructures which integrate heterogeneous applications (Encapsulation) • allows combination of services (Orchestration) and data exchange within business processes Warning systems will evolve over time: New sensor types might be added, old sensors will be replaced and processing components will be improved. From a collection of few basic services it shall be possible to compose more complex functionality essential for specific warning systems. Given these requirements a flexible infrastructure is a prerequisite for sustainable systems and their architecture must be

  15. Architecture of a high-performance surgical guidance system based on C-arm cone-beam CT: software platform for technical integration and clinical translation

    Science.gov (United States)

    Uneri, Ali; Schafer, Sebastian; Mirota, Daniel; Nithiananthan, Sajendra; Otake, Yoshito; Reaungamornrat, Sureerat; Yoo, Jongheun; Stayman, J. Webster; Reh, Douglas; Gallia, Gary L.; Khanna, A. Jay; Hager, Gregory; Taylor, Russell H.; Kleinszig, Gerhard; Siewerdsen, Jeffrey H.

    2011-03-01

    Intraoperative imaging modalities are becoming more prevalent in recent years, and the need for integration of these modalities with surgical guidance is rising, creating new possibilities as well as challenges. In the context of such emerging technologies and new clinical applications, a software architecture for cone-beam CT (CBCT) guided surgery has been developed with emphasis on binding open-source surgical navigation libraries and integrating intraoperative CBCT with novel, application-specific registration and guidance technologies. The architecture design is focused on accelerating translation of task-specific technical development in a wide range of applications, including orthopaedic, head-and-neck, and thoracic surgeries. The surgical guidance system is interfaced with a prototype mobile C-arm for high-quality CBCT and through a modular software architecture, integration of different tools and devices consistent with surgical workflow in each of these applications is realized. Specific modules are developed according to the surgical task, such as: 3D-3D rigid or deformable registration of preoperative images, surgical planning data, and up-to-date CBCT images; 3D-2D registration of planning and image data in real-time fluoroscopy and/or digitally reconstructed radiographs (DRRs); compatibility with infrared, electromagnetic, and video-based trackers used individually or in hybrid arrangements; augmented overlay of image and planning data in endoscopic or in-room video; real-time "virtual fluoroscopy" computed from GPU-accelerated DRRs; and multi-modality image display. The platform aims to minimize offline data processing by exposing quantitative tools that analyze and communicate factors of geometric precision. The system was translated to preclinical phantom and cadaver studies for assessment of fiducial (FRE) and target registration error (TRE) showing sub-mm accuracy in targeting and video overlay within intraoperative CBCT. The work culminates in

  16. 区域性国际物流综合服务平台构建研究%Study On Constructing the Internationally-faced Regional Logistics Integrated Service Platform

    Institute of Scientific and Technical Information of China (English)

    王成林; 蒲锋; 田雪; 杨丽; 王克金

    2011-01-01

    The paper first analyzes the background characteristics of international logistics operations and concludes on the attributes of the international logistics agents. Then it briefly overviews the current status of the construction of international logistics service platforms, on the basis of which, requirements on the construction of the internationally-faced regional logistics integrated service platform are analyzed and the service mode of such platform is proposed.%分析了国际物流的背景特征,得出了国际物流参与主体属性,并对国际物流服务平台建设现状进行了简要分析,在此基础上分析了区域性国际物流综合服务平台构建的构建需求,提出了区域性国际物流综合服务平台的服务模式.

  17. 基于HL7标准的医院信息集成平台建设探索%Exploration of Hospital Information Integration Platform Construction Based on HL7 Standard

    Institute of Scientific and Technical Information of China (English)

    葛小玲; 薛颜波; 宓林晖; 徐虹

    2014-01-01

    目的:优化医院现有业务应用系统间的集成模式,探索建设支持业务系统快速集成的医院信息集成平台。方法:参照国际医疗信息交换标准--HL7,对原有业务系统接口进行标准化改造,建设医院信息集成平台,并通过集成平台实现业务系统之间数据的交换与共享。结果:以HL7作为数据交换标准,利用医院信息集成平台实现了医疗服务资源的最优化整合和业务协同。结论:基于HL7标准建设医院信息集成平台,可以大大降低业务系统间的耦合性,使业务系统易于升级、维护和扩展,增强了医院整体信息系统的柔性。%Objective: To optimize the integration pattern among existing business application systems of hospital, and explore the construction of hospital information integration platform which supports the rapid integration of business system. Method: With reference to HL7, the international medical information exchange standard, the standardization transformation of the original business system interface is carried out, hospital information integration platform is constructed, and data exchange and sharing among business systems is realized through the integration platform. Results: With HL7 as the data exchange standard, using the hospital information integration platform, optimized integration and business synergy of medical service resources are realized. Conclusion: The construction of hospital information integration platform based on HL7 standard can greatly reduce the coupling between the business systems, make the system easy to upgrade, maintain and expand, and improve the flexibility of the hospital's overall information system.

  18. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden ...... not have to be very intelligent. This is gradually taken over by applications on smart phones. The ITS Platform with 425 test drivers is now completely developed and can be used for technological testing of e.g. payment systems.......Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...

  19. Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.

    Science.gov (United States)

    Lakatos, Anita; Goldberg, Natalie R S; Blurton-Jones, Mathew

    2017-03-10

    We previously demonstrated that transplantation of murine neural stem cells (NSCs) can improve motor and cognitive function in a transgenic model of Dementia with Lewy Bodies (DLB). These benefits occurred without changes in human α-synuclein pathology and were mediated in part by stem cell-induced elevation of brain-derived neurotrophic factor (BDNF). However, instrastriatal NSC transplantation likely alters the brain microenvironment via multiple mechanisms that may synergize to promote cognitive and motor recovery. The underlying neurobiology that mediates such restoration no doubt involves numerous genes acting in concert to modulate signaling within and between host brain cells and transplanted NSCs. In order to identify functionally connected gene networks and additional mechanisms that may contribute to stem cell-induced benefits, we performed weighted gene co-expression network analysis (WGCNA) on striatal tissue isolated from NSC- and vehicle-injected wild-type and DLB mice. Combining continuous behavioral and biochemical data with genome wide expression via network analysis proved to be a powerful approach; revealing significant alterations in immune response, neurotransmission, and mitochondria function. Taken together, these data shed further light on the gene network and biological processes that underlie the therapeutic effects of NSC transplantation on α-synuclein induced cognitive and motor impairments, thereby highlighting additional therapeutic targets for synucleinopathies.

  20. Application Practice of Integrated Platform of Software System%软件系统集成平台的应用实践

    Institute of Scientific and Technical Information of China (English)

    张书娟

    2015-01-01

    Tianjin Iron and Steel Group Company Limited (TISC) integrated information platform and daily cost accounting and analysis information system is comprised of five aspects of purchasing and storage, production planning, quality control, sales and financial cost. The paper introduces the process that Tianjin Iron and Steel Group Co., Ltd. utilized SAPNetWeaver PI to realize the interconnection and intercommunication of the data flow and information flow of each business function from TISC production and manufacturing system, ERP system and other sectors with that of the said system, including information communication configuration and business interface design. The new system features good flexibility, powerful message detecting and measuring function, standard interface technique and easy interface contain adding, erasing and changing.%天钢一体化信息平台与日成本核算和分析信息系统包括采购仓储、生产计划、质量控制、销售、财务成本五大部分。介绍了天津钢铁集团公司采用SAPNetWeaver PI,实现该系统与公司的生产制造系统、ERP系统和其它专业系统的各个业务功能的数据流、信息流的互通互联的过程,包括信息通讯配置和业务接口设计等。新系统具有灵活性较好、消息检测功能强大、采用了标准接口技术和增删改接口内容简便易行的特点。

  1. A novel, integrated forensic microdevice on a rotation-driven platform: Buccal swab to STR product in less than 2 h.

    Science.gov (United States)

    Cox, Jordan O; DeCarmen, Teresa Sikes; Ouyang, Yiwen; Strachan, Briony; Sloane, Hillary; Connon, Cathey; Gibson, Kemper; Jackson, Kimberly; Landers, James P; Cruz, Tracey Dawson

    2016-12-01

    This work describes the development of a novel microdevice for forensic DNA processing of reference swabs. This microdevice incorporates an enzyme-based assay for DNA preparation, which allows for faster processing times and reduced sample handling. Infrared-mediated PCR (IR-PCR) is used for STR amplification using a custom reaction mixture, allowing for amplification of STR loci in 45 min while circumventing the limitations of traditional block thermocyclers. Uniquely positioned valves coupled with a simple rotational platform are used to exert fluidic control, eliminating the need for bulky external equipment. All microdevices were fabricated using laser ablation and thermal bonding of PMMA layers. Using this microdevice, the enzyme-mediated DNA liberation module produced DNA yields similar to or higher than those produced using the traditional (tube-based) protocol. Initial microdevice IR-PCR experiments to test the amplification module and reaction (using Phusion Flash/SpeedSTAR) generated near-full profiles that suffered from interlocus peak imbalance and poor adenylation (significant -A). However, subsequent attempts using KAPA 2G and Pfu Ultra polymerases generated full STR profiles with improved interlocus balance and the expected adenylated product. A fully integrated run designed to test microfluidic control successfully generated CE-ready STR amplicons in less than 2 h (STR profiles were developed that were consistent with those produced using conventional DNA purification and STR amplification methods. This method is a smaller, more elegant solution than current microdevice methods and offers a cheaper, hands-free, closed-system alternative to traditional forensic methods.

  2. A 9 MHz-2.4 GHz Fully Integrated Transceiver IC for a Microfluidic-CMOS Platform Dedicated to Miniaturized Dielectric Spectroscopy.

    Science.gov (United States)

    Bakhshiani, Mehran; Suster, Michael A; Mohseni, Pedram

    2015-12-01

    This paper presents a fully integrated transceiver IC as part of a self-sustained, microfluidic-CMOS platform for miniaturized dielectric spectroscopy (DS) from MHz to GHz. Fabricated in AMS 0.35 μm 2P/4M RF CMOS, the transmitter (TX) part of the IC generates a single-tone sinusoidal signal with frequency tunability in the range of ~ 9 MHz-2.4 GHz to excite a three-dimensional (3D), parallel-plate, capacitive sensor with a floating electrode and 9 μL microfluidic channel for sample delivery. With a material-under-test (MUT) loaded into the sensor, the receiver (RX) part of the IC employs broadband frequency response analysis (bFRA) methodology to measure the amplitude and phase of the RF excitation signal after transmission through the sensor. A one-time, 6-point sensor calibration algorithm then extracts both the real and imaginary parts of the MUT complex permittivity, ϵr, from IC measurements of the sensor transmission characteristics in the voltage domain. The "sensor + IC" is fully capable of differentiating among de-ionized (DI) water, phosphate-buffered saline (PBS), and alcoholic beverages in tests conducted at four excitation frequencies of ∼ 50 MHz , 500 MHz, 1.5 GHz, and 2.4 GHz generated by the TX. Moreover, permittivity readings of PBS by the sensor interfaced with the IC at six excitation frequencies in the range of ~ 50 MHz-2.4 GHz are in excellent agreement (rms error of 1.7% (real) and 7.2% (imaginary)) with those from bulk-solution reference measurements by commercial benchtop equipment. The total power consumption of the IC is with 1.5 V (analog) and 3.3 V (digital) supplies.

  3. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  4. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies tho...

  5. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports......This study presents a model for studying the innovative capabilities of digital payment platforms in regards to open innovation integration and commercialization. We perceive digital platforms as layered modular IT artifacts, where platform governance and the configuration of platform layers impact...... the intended conjoint commercialization efforts. Furthermore, the architectural design of digital platforms impacts the access to commercialization, resulting to an exclusion or inclusion strategy in accessing value opportunities. Our findings contribute to the open innovation and digital platform literature...

  6. Improved thermal isolation of silicon suspended platforms for an all-silicon thermoelectric microgenerator based on large scale integration of Si nanowires as thermoelectric material

    Science.gov (United States)

    Fonseca, L.; Donmez, I.; Salleras, M.; Calaza, C.; Gadea, G.; Santos, J. D.; Morata, A.; Tarancon, A.

    2015-12-01

    Special suspended micro-platforms have been designed as a part of silicon compatible planar thermoelectric microgenerators. Bottom-up grown silicon nanowires are going to bridge in the future such platforms to the surrounding silicon bulk rim. They will act as thermoelectric material thus configuring an all-silicon thermoelectric device. In the new platform design other additional bridging elements (usually auxiliary support silicon beams) are substituted by low conductance thin film dielectric membranes in order to maximize the temperature difference developed between both areas. These membranes follow a sieve-like design that allows fabricating them with a short additional wet anisotropic etch step.

  7. Electrorheological fluid-actuated flexible platform

    Science.gov (United States)

    Liu, Liyu; Niu, Xize; Wen, Weijia; Sheng, Ping

    2006-04-01

    The design, fabrication, and performance of an electrorheological (ER) fluid-actuated flexible platform integrated on a microfluidic chip are reported in this letter. The digitally regulated ER microvalves control the four diaphragms on which a platform is sustained. With electrical input signals, the platform can perform vibrations at tunable frequencies as well as generate complex leveling modes. The flexible platform can potentially act as a microdamper when its inputs are generated from a sensor, in combination with a feedback control system.

  8. Design and Implementation of Distributed Management Platform for Integrated Systems%校园分布式系统集成管理平台的设计与实现

    Institute of Scientific and Technical Information of China (English)

    李丹

    2013-01-01

      为解决目前高校多层级的分布式系统集成平台导致的管理问题,提出一种集中式和分布式管理机制相结合的管理平台,引入资源、域和工作组等相关概念,分别从物理层和业务层对集成系统进行管理,提高了集成平台的适应性。管理平台采用J2EE、Streams、web服务等开发技术实现。%In order to solve the problem of college,which caused by the distributed,multi-level management platform for integrated system,a management plaform combinated of a centralized and distributed management mechanism is proposed.The introduction of related concepts such as resources,domain and workgroup lead to the integrated system management from the phycal layer and the business layer which improve the adaptability of the integration platform.The development of management platform use J2EE,Streams and web services and so on.

  9. Towards a Framework of Digital Platform Competition

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2016-01-01

    between monopolistic (i.e., Pingit) and federated (i.e., Paym) mobile payment platforms to illustrate its applicability and yield principles on the nature and impact of competition among platform-driven ubiquitous systems. Preliminary findings indicate that monopolistic mobile digital platforms attempt......This paper advances a framework for examining the competitive principles of mobile payment platforms. We postulate that the strategic interplay of platform layers will drive the competitive dynamics of platform-driven ubiquitous systems. This framework has been employed in a comparative case study...... and integration among platform layers give rise to commodity and value platform layers that translate into competitive battlegrounds among mobile payment services. This paper therefore represents a concrete step in unraveling the competitive dynamics of platform-driven ubiquitous systems from an architectural...

  10. Platform Constellations

    DEFF Research Database (Denmark)

    Staykova, Kalina Stefanova; Damsgaard, Jan

    2016-01-01

    messaging apps KakaoTalk and LINE, we are able to gain valuable insights about the nature of these new constructions and to capture and synthesize their main characteristics in a framework. Our results show that platform constellations possess unique innovative capabilities, which can improve users......’ acquisition and users’ engagement rates as well as unlock new sources of value creation and diversify revenue streams....

  11. Contamination assessment of a coastal lagoon (Ria de Aveiro, Portugal) using defence and damage biochemical indicators in gill of Liza aurata - An integrated biomarker approach

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, M. [CESAM and Department of Biology, University of Aveiro, 3810-193 Aveiro (Portugal)], E-mail: migueloliveira@ua.pt; Maria, V.L. [CIMA and Faculty of Marine and Environmental Sciences, University of Algarve, Campus Gambelas, 8005-139 Faro (Portugal); Ahmad, I. [CESAM and Department of Biology, University of Aveiro, 3810-193 Aveiro (Portugal); Serafim, A.; Bebianno, M.J. [CIMA and Faculty of Marine and Environmental Sciences, University of Algarve, Campus Gambelas, 8005-139 Faro (Portugal); Pacheco, M.; Santos, M.A. [CESAM and Department of Biology, University of Aveiro, 3810-193 Aveiro (Portugal)

    2009-03-15

    Fish gill importance in toxicants uptake, bioconcentration and excretion allied to meagre knowledge on branchial damage/protection responses substantiate this study. Five critical sites in Ria de Aveiro (Portugal) were assessed in comparison with a reference site (Torreira), focusing on Liza aurata gill antioxidant defences versus damage (oxidative and genetic). Only in Barra fish displayed damage (lipid peroxidation) though no differences were found in antioxidants. In all other sites, except Rio, antioxidant alterations were found. Thus, fish from Gafanha, Laranjo and Vagos showed higher total glutathione, glutathione peroxidase and catalase. Higher glutathione reductase and glutathione S-transferase activity was also found in the first and the last sites, respectively. In Laranjo, metallothionein levels were higher though lower in Gafanha and Vagos. In general, damage was not accompanied by defences weakening confirming that predicting damage based on antioxidants depletion is not straightforward. The integrated biomarker response index ranked sites as: Gafanha > Barra > Laranjo > Vagos > Rio > Torreira. - The integration of antioxidant defence and damage responses in fish, using gill as a key organ, can improve the aquatic contamination assessment.

  12. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  13. Integrating ASCAT surface soil moisture and GEOV1 leaf area index into the SURFEX modelling platform: a land data assimilation application over France

    Directory of Open Access Journals (Sweden)

    A. L. Barbu

    2014-01-01

    Full Text Available The land monitoring service of the European Copernicus programme has developed a set of satellite-based biogeophysical products, including surface soil moisture (SSM and leaf area index (LAI. This study investigates the impact of joint assimilation of remotely sensed SSM derived from Advanced Scatterometer (ASCAT backscatter data and the Copernicus Global Land GEOV1 satellite-based LAI product into the the vegetation growth version of the Interactions between Soil Biosphere Atmosphere (ISBA-A-gs land surface model within the the externalised surface model (SURFEX modelling platform of Météo-France. The ASCAT data were bias corrected with respect to the model climatology by using a seasonal-based CDF (Cumulative Distribution Function matching technique. A multivariate multi-scale land data assimilation system (LDAS based on the extended Kalman Filter (EKF is used for monitoring the soil moisture, terrestrial vegetation, surface carbon and energy fluxes across the domain of France at a spatial resolution of 8 km. Each model grid box is divided into a number of land covers, each having its own set of prognostic variables. The filter algorithm is designed to provide a distinct analysis for each land cover while using one observation per grid box. The updated values are aggregated by computing a weighted average. In this study, it is demonstrated that the assimilation scheme works effectively within the ISBA-A-gs model over a four-year period (2008–2011. The EKF is able to extract useful information from the data signal at the grid scale and distribute the root-zone soil moisture and LAI increments throughout the mosaic structure of the model. The impact of the assimilation on the vegetation phenology and on the water and carbon fluxes varies from one season to another. The spring drought of 2011 is an interesting case study of the potential of the assimilation to improve drought monitoring. A comparison between simulated and in situ soil

  14. Design of Integrated Automation System Platform of Coal Mine Based on Wonderware IAS and Its Application%基于Wonderware IAS的煤矿综合自动化系统平台的设计和应用

    Institute of Scientific and Technical Information of China (English)

    顾对芳; 王为广; 李红霞; 丁继存

    2012-01-01

    根据济宁三号煤矿的实际情况,提出了一种基于Wonderware IAS的煤矿综合自动化系统平台设计方案,介绍了该平台的结构、IAS的开发、与煤矿其他子系统接口协议的通信方法、基于InTouch组态软件的HMI的设计方法等.实际应用表明,该平台运行稳定,有效提高了煤矿的信息化程度,解决了以往各系统各自运行、各自管理的弊端,达到了减员增效的目的.%According to actual situation of Jining No. 3 Coal Mine, a design scheme of integrated automation system platform of coal mine based on Wonderware IAS was proposed. Platform structure, IAS development, communication between the platform and interface protocol of other subsystem, HMI design method based on InTouch configuration software were introduced. The practical application showed that the platform is stable in operation, and improves coal mine informatization degree effectively, solves problems of self running and self management, which achieves goal of increasing efficiency by downsizing staff.

  15. The "Vsoil Platform" : a tool to integrate the various physical, chemical and biological processes contributing to the soil functioning at the local scale.

    Science.gov (United States)

    Lafolie, François; Cousin, Isabelle; Mollier, Alain; Pot, Valérie; Moitrier, Nicolas; Balesdent, Jérome; bruckler, Laurent; Moitrier, Nathalie; Nouguier, Cédric; Richard, Guy

    2014-05-01

    Models describing the soil functioning are valuable tools for addressing challenging issues related to agricultural production, soil protection or biogeochemical cycles. Coupling models that address different scientific fields is actually required in order to develop numerical tools able to simulate the complex interactions and feed-backs occurring within a soil profile in interaction with climate and human activities. We present here a component-based modelling platform named "VSoil", that aims at designing, developing, implementing and coupling numerical representation of biogeochemical and physical processes in soil, from the aggregate to the profile scales. The platform consists of four softwares, i) Vsoil_Processes dedicated to the conceptual description of processes and of their inputs and outputs, ii) Vsoil_Modules devoted to the development of numerical representation of elementary processes as modules, iii) Vsoil_Models which permits the coupling of modules to create models, iv) Vsoil_Player for the run of the model and the primary analysis of results. The platform is designed to be a collaborative tool, helping scientists to share not only their models, but also the scientific knowledge on which the models are built. The platform is based on the idea that processes of any kind can be described and characterized by their inputs (state variables required) and their outputs. The links between the processes are automatically detected by the platform softwares. For any process, several numerical representations (modules) can be developed and made available to platform users. When developing modules, the platform takes care of many aspects of the development task so that the user can focus on numerical calculations. Fortran2008 and C++ are the supported languages and existing codes can be easily incorporated into platform modules. Building a model from available modules simply requires selecting the processes being accounted for and for each process a module

  16. A case study for integrated STEM outreach in an urban setting using a do-it-yourself vertical jump measurement platform.

    Science.gov (United States)

    Drazan, John F; Danielsen, Heather; Vercelletto, Matthew; Loya, Amy; Davis, James; Eglash, Ron

    2016-08-01

    The purpose of this study was to develop and deploy a low cost vertical jump platform using readily available materials for Science, Technology, Engineering, and Mathematics (STEM) education and outreach in the inner city. The platform was used to measure the jumping ability of participants to introduce students to the collection and analysis of scientific data in an engaging, accessible manner. This system was designed and fabricated by a student team of engineers as part of a socially informed engineering and design class. The vertical jump platform has been utilized in 10 classroom lectures in physics and biology. The system was also used in an after school program in which high school volunteers prepared a basketball based STEM outreach program, and at a community outreach events with over 100 participants. At present, the same group of high school students are now building their own set of vertical jump platform under the mentorship of engineering undergraduates. The construction and usage of the vertical jump platform provides an accessible introduction to the STEM fields within the urban community.

  17. Integrated Monitoring Technology of Dynamic Positioning in Semi-submersible Drilling Platform%半潜式钻井平台动力定位集成监控技术

    Institute of Scientific and Technical Information of China (English)

    高文; 陈红卫

    2011-01-01

    针对目前海洋钻井信息管理平台中集成能力、可操作性和可扩展性存在的问题,研究了半潜式钻井平台动力定位集成监控技术;介绍了钻井平台动力定位系统组成和信息集成技术;设计了监控系统网络结构和软件结构;应用OPC技术设计客户端解决了网络异构问题,实现了钻井平台动力定位集成监控;最后利用PLC模拟了吊舱和柴油发电机数据环境,对OPC客户端进行了测试;测试结果表明,客户端能够与不同服务器建立连接,实现对不同系统、设备数据的读写.%Specifically for solving the problems of offshore drilling information management platform such as integrated ability, operabili-ty and extensibility, the integrated monitoring technology of dynamic positioning in semi -submersible drilling platform is studied. Not only integrated technology and dynamic positioning system are introduced, but also network architecture and software architecture are designed. Designing client based on OPC technology solves the problem of heterogeneous networks to achieve integrated monitoring for dynamic positioning system of Semi - submersible drilling platform. Finally using PLC simulates data environment of pod and diesel generator to test client. The results show that the client can connect with different servers and exchange data with different systems and equipments.

  18. Temperature and salinity profiles from expendable bathythermograph (XBT) and CTD casts from NOAA Ship MILLER FREEMAN and other Platforms from Coastal Waters of Washington/Oregon and other locations in support of the Integrated Global Ocean Services System (IGOSS) from 1977-07-12 to 1983-07-26 (NCEI Accession 8300102)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT and CTD data were collected from NOAA Ship MILLER FREEMAN and other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data...

  19. Temperature profiles from expendable bathythermograph (XBT) casts DIAMANTINA and other Platforms from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) and the Pacific Acoustic Research Kaneohe-Alaska (PARKA) from 12 December 1966 to 29 September 1974 (NODC Accession 7500700)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the DIAMANTINA and other Platforms in support of the Integrated Global Ocean Services System (IGOSS) and the Pacific Acoustic Research...

  20. Temperature profiles from expendable bathythermograph (XBT) casts from the BJARNI SAEMUNDSSON and Other Platforms in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 02 February 1974 to 05 April 1974 (NODC Accession 7400351)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the BJARNI SAEMUNDSSON and Other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data were...

  1. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other platforms in the North Pacific Ocean, Atlantic Ocean and other seas in support of the Integrated Global Ocean Services System (IGOSS) from 1992-04-01 to 1992-04-30 (NCEI Accession 9200107)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  2. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other PLATFORMS from the North Pacific Ocean and North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 1991-05-01 to 1991-05-31 (NCEI Accession 9100108)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  3. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other PLATFORMS from the North Pacific Ocean and North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 1991-08-01 to 1991-08-31 (NCEI Accession 9100174)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  4. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other PLATFORMS from the North Pacific Ocean and North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 1991-10-01 to 1991-10-31 (NCEI Accession 9100209)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  5. Temperature and salinity profiles from CTD casts from the VOLNA and other PLATFORMS from the North/South Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 February 1989 to 27 February 1989 (NODC Accession 8900053)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VOLNA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  6. Temperature and salinity profiles from CTD casts from the OKEAN and other PLATFORMS from the North/South Atlantic Ocean and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 October 1989 to 31 October 1989 (NODC Accession 8900296)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the OKEAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  7. Temperature and salinity profiles from CTD casts from the OKEAN and other PLATFORMS from the North Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 July 1989 to 31 July 1989 (NODC Accession 8900256)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the OKEAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  8. Temperature and salinity profiles from CTD casts from NOAA Ship MILLER FREEMAN and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 1991-07-01 to 1991-07-31 (NCEI Accession 9100146)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  9. Temperature and salinity profiles from CTD casts from NOAA Ship THOMAS JEFFERSON and other PLATFORMS from the North/South Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 1991-11-01 to 1991-11-30 (NCEI Accession 9100243)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship THOMAS JEFFERSON and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  10. Temperature and salinity profiles from CTD casts from the OKEAN and other PLATFORMS from the North Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 December 1988 to 31 December 1988 (NODC Accession 8900007)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the OKEAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  11. 主配网调控一体化图形平台设计%Design of Graphics Platform for Scheduling and Control Integration of Main and Distribution Network

    Institute of Scientific and Technical Information of China (English)

    汪磊; 魏丽芳; 王克谦; 黄志勇

    2012-01-01

    For the integrated scheduling-control construction of main and distribution network in the operation and management of power grid, the paper has proposed a designing scheme of integrated operation- management graphics platform. Common information model and scalable vector graphics format are used to complete docking between main network graphic and distribution network graphic of power gird, and then to import them to the same graphic platform. By using the technology of integrated modeling of power gird topology, graph-database integration, data transmission integration and misoperation-proof lockout integration, the platform implements the function including integrated graph management,operation mode real-time monitoring and management, dispatching daily management, security correction based on operation simulations and operation mode aid-analysis. Therefore, the previous drawbacks of mutual independence in the management of main and distribution networks can be resolved, which will provide the guarantee for the integration management of main and distribution network.%针对电网运行管理主配网调控一体化建设的需要,文中提出了一体化运行管理图形平台的设计方案.采用公共信息模型和可缩放矢量图形文件格式将电网主网图形和配网图形对接并导入同一电网图形平台,利用电网一体化建模、图库一体化、数据传输一体化和五防一体化技术实现了一体化图形管理、运行方式实时监控与管理、调度日常管理、系统操作模拟的安全校核、运行方式辅助分析等五大功能模块,解决了以往主配网管理相互独立的弊端,为主配网调控一体化管理提供了保障.

  12. M ulti-source dynamic integration for SaaS collaborative platform of industrial chain%面向产业链协同SaaS平台的多源信息动态集成技术

    Institute of Scientific and Technical Information of China (English)

    潘华; 王淑营; 孙林夫; 吕瑞

    2015-01-01

    针对产业链协同平台多源信息集成的需求,提出面向SaaS平台的多源信息动态集成解决方案。以平台上多数据源信息集成模型的设计与实现为核心,建立以平台为核心的多源信息集成规则,设计并实现基于SaaS平台的多源信息集成体系架构,基于XM L和Web Service技术建立面向客户端的多源信息安装向导,实现多源信息数据格式的智能化转换,通过W eb数据集成接口,实现企业与平台间数据的动态集成。其在汽车零部件产业链协同平台查询经销商社会库存的应用验证了该技术的可行性和有效性。%A multi‐source dynamic integration solution was proposed for the requirements of SaaS collaborative platform of indus‐trial chain .Taking the design and implementation of multi‐source message integration model as the core concept ,the protocol of multi‐source message integration was proposed and the framework of multi‐source message integration was designed .Based on XML and Web Service ,the integration pilot for client was the created ,the intelligent configuration of multi‐source message inte‐gration was realized .According to the integration interface of Web data ,the dynamic integration between platform and corpora‐tion was realized .The results of research were applied in querying social stock of the cooperative platform of auto industrial sup‐ply‐chain ,and the integration technology was verified to be feasible and effective .

  13. Development of Distributed General Integrated Navigation Simulation Platform for Spacecraft%空间飞行器分布式通用组合导航仿真平台方案研究

    Institute of Scientific and Technical Information of China (English)

    周姜滨; 袁建平; 罗建军; 岳晓奎

    2008-01-01

    在研制空间飞行器导航系统的过程中,搭建导航仿真平台能够有效地节约成本并缩短研发周期.在模块化、通用化和标准化设计原则的指导下,利用多台计算机和相应的数据总线开发了空间飞行器分布式通用组合导航仿真平台.在空间飞行器导航系统特性分析的基础上,提出了捷联惯性导航系统、GPS、脉冲星导航系统、磁强计和星敏感器组合导航方案,设计了仿真平台的结构,论述了仿真平台的硬件设计、软件开发和算法,并探讨了仿真平台的扩展性能.试验表明该仿真平台能够逼真地模拟空间飞行器导航系统,并为设计者提供有益的建议.%Navigation system, which supplies high precision navigation information, is a crucial part of a spacecraft. Space flight tests, to demonstrate the performance of a spacecraft navigation system, are usually very expensive and high risk. In order to reduce cost and shorten period of development during designing a spacecraft navigation system, building a navigation simulation platform becomes an efficient method. A distributed general integrated navigation simulation platform was developed using multiple computers and data bus under the design principle of modularization universalization and standardization. Based on the characteristic analysis of a spacecraft navigation system, an integrated navigation scheme combining strap-down inertial navigation system (SINS), global positioning system (GPS), x-ray pulsar navigation system (XPNS), magnetometer and star sensor was proposed. The scheme used the federated Kalman filter algorithm as its information fusion algorithm. The configuration of the distributed simulation platform was designed to realize integrated navigation function including Trajectory Creator Subsystem, Inertial Measurement Unit (IMU) Subsystem, SINS Subsystem, GPS Subsystem, XPNS Subsystem, Magnetometer Subsystem, Star Sensor Subsystem and Integrated Navigation

  14. Design of development platform for hosted applications in integrated module avionics system%面向综合模块化航电系统的驻留应用开发平台设计

    Institute of Scientific and Technical Information of China (English)

    王运盛; 雷航

    2012-01-01

    The common computing resources in the Integrated Modular Avionics (IMA) system provide the hosted applications with temporal and spatial partitioning platform. The platform for applications development should comply with the ARINC 653 specification which defines the application executive interfaces for partitioning operation system. By porting and developing the Board Support Package (BSP) and AFDX network driver, for the first time, an IMA platform solution for hosted application development was achieved based on the C2K, a Commercial Off-The-Shelf (COTS) single board computer. The functionality and performance of the COTS based platform are similar to the popular common computing resources in IMA of modern civil transportation aircraft, offering a development platform for hosted applications development and debug at a pretty lower costs.%综合模块化航电系统采用时间和空间分区技术隔离不同的应用程序,驻留在分区中应用程序的开发依赖于符合ARINC 653及相关接口和通信规范的开发平台.通过移植传统操作系统的板级支持包和开发驱动程序,使得商业单板计算机C2K支持符合ARINC 653规范的VxWorks 653分区操作系统并提供AFDX网络接口,首次实现了基于商业单板计算机C2K的驻留应用开发平台,其主要功能和性能与目前主流的大型客机综合模块化航电系统相当,可用来支持驻留应用的开发和调试,大幅度降低了成本.

  15. Study on Simulation and Experiment Platform of Integrated High-speed Railway Traffic Control%高速铁路行车调度指挥一体化仿真实验平台设计与研究

    Institute of Scientific and Technical Information of China (English)

    周妍; 周磊山

    2012-01-01

    研究高速铁路行车调度指挥仿真验证与人员培训实验平台设计.依据管控一体化思想,在分析高速铁路行车特点的基础上,设计高速铁路行车调度指挥一体化仿真实验平台的结构和功能.该平台可实现列车运行计划编制一列车运行计划调整一半实物沙盘列车实时运行仿真全过程的科研验证和实践教学模拟操作的相关功能,并将铁路行车仿真技术领域直接延伸到列控层,能够满足半实物仿真环境下,高速铁路行车调度新理论的实践验证和调度员及学生业务培训需求.%The paper studied design of the simulation and experiment platform which aimed at simulation verification and personnel training for high-speed railway traffic control. On the basis of the theory of integrated management and control and the analysis on traffic operating characteristics of high-speed railways, the structure and functions of the simulation and experiment platform were designed. The platform verifies the whole process of simulating train diagram formulation,train diagram adjustment and sand table train real-time operation, and realizes functions of teaching simulation. The platform integrates train control into the dispatching simulation system, greatly improves the experiment effect and meets the need of new train organization method verification and dispatching skill training.

  16. 基于专家医院的远程医疗管理平台整合方案研究%Integrated Solution Research of the Telemedicine Management Platform Based on Expert Hospital

    Institute of Scientific and Technical Information of China (English)

    李汉民; 商建国; 肖辉; 李志强

    2015-01-01

    Objective: Design a normal operation and management platform to adapt to the development of telemedicine business. Method:On the basis of analyzing the existing problems of remote medical building, this paper proposes remote medical management platform architecture of normalization operations, analyzes remote medical business applications and supervision under the architecture. Results: Scheme helps integrate telemedicine information system within the province, achieve high-quality medical resources sink, innovative remote medical service model. Conclusion: The unified data architecture and management standards will help promote the integration of provincial telemedicine platform, promote national telemedicine management platform construction, and achieve nationwide telemedicine business cooperative applications.%目的:设计一套适应远程医疗业务发展的常态化运营管理平台。方法:在分析远程医疗建设现存问题的基础上,提出了常态化运营的远程医疗管理平台架构,并分析了该架构下的远程医疗业务应用及业务监管。结果:方案有助于整合省域内远程医疗信息系统,实现优质医疗资源下沉,创新远程医疗服务模式。结论:统一的数据架构和管理规范有利于推进各省远程医疗平台融合,推动国家级远程医疗管理平台建设,实现全国范围的远程医疗业务协同应用。

  17. The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

    Science.gov (United States)

    Tanino, Motohiko; Debily, Marie-Anne; Tamura, Takuro; Hishiki, Teruyoshi; Ogasawara, Osamu; Murakawa, Katsuji; Kawamoto, Shoko; Itoh, Kouichi; Watanabe, Shinya; de Souza, Sandro José; Imbeaud, Sandrine; Graudens, Esther; Eveno, Eric; Hilton, Phillip; Sudo, Yukio; Kelso, Janet; Ikeo, Kazuho; Imanishi, Tadashi; Gojobori, Takashi; Auffray, Charles; Hide, Winston; Okubo, Kousaku

    2005-01-01

    The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein expression data from multiple platforms that has been associated with both manually annotated full-length cDNAs from H-InvDB and RefSeq sequences. Of the H-Inv predicted genes, 18 897 have associated expression data generated by at least one platform. H-ANGEL utilizes categorized mRNA expression data from both publicly available and proprietary sources. It incorporates data generated by three types of methods from seven different platforms. The data are provided to the user in the form of a web-based viewer with numerous query options. H-ANGEL is updated with each new release of cDNA and genome sequence build. In future editions, we will incorporate the capability for expression data updates from existing and new platforms. H-ANGEL is accessible at http://www.jbirc.aist.go.jp/hinv/h-angel/. PMID:15608263

  18. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  19. Metal enhanced fluorescence of flavin mononucleotide using new plasmonic platform

    Science.gov (United States)

    Synak, Anna; Grobelna, Beata; Raut, Sangram; Bojarski, Piotr; Gryczyński, Ignacy; Karczewski, Jakub; Shtoyko, Tanya

    2016-09-01

    New plasmonic platform was successfully obtained to investigate the increase of fluorescence intensity of a fluorophore in the presence of silver nanoparticles. A flavin mononucleotide, was selected by us as a fluorophore for this study as a very important biological compound playing a key role in many biochemical process. Plasmonic platforms were characterized by means of luminescence spectroscopy. Flavin mononucleotide deposited on plasmonic platform exhibits dramatic emission enhancements in presence of silver nanoparticles deposited on gold mirror.

  20. The Management Platform Based on MVC in the Meteorology Sensor Network with Multi-Component Integration%基于MVC的多组件融合的气象传感网管理平台

    Institute of Scientific and Technical Information of China (English)

    朱兴宇; 杜景林; 沈晓燕

    2016-01-01

    使用WebForm架构开发的信息管理系统和插件式的数据图形显示不利于后期系统拓展和维护。针对这种情况,气象传感网管理平台采用MVC设计模式和组建融合的多组件图形库进行开发。首先研究分析MVC设计模式,其次分析气象传感网需求以及平台开发需要的技术,然后利用工具对平台进行设计,最后通过集成开发工具使用Razor视图引擎,Linq to Sql数据查询技术,融合MATLAB工具实现气象传感网信息管理系统。系统的整体运行情况表明,MVC设计模式和多组件图形库极大方便了平台的设计与开发,平台实现了气象信息管理系统的业务需求和管理功能。%The information management system using architecture WebForm and plug-dispersed data graphic display are not conducive to the latter part of the system development and maintenance. Weather sensor network management platform uses MVC design pattern and the multi-component integration graphics library. First,we analysis the MVC design pattern, then we make clear the needs of meteorological sensor networks and the technology used in the platform, and then use tools to design the platform, and finally we make the program coding by using Razor view engine , Linq to Sql data query technology and MATLAB in the integrated development tool to complete the platform. The working of the system shows that, the MVC design pattern and the multi-component integration graphics library greatly facilitate the design and development of the platform and it can well meet basic business requirements and management functions.

  1. 煤矿安全监测综合信息联网平台的设计及应用%Design of Integrated Information Networking Platform for Coal Mine Safety Monitoring and Its Application

    Institute of Scientific and Technical Information of China (English)

    杜建平

    2011-01-01

    阐述了山西离柳焦煤集团有限公司安全监测综合信息联网平台的设计与应用情况.通过该平台,煤矿企业集团公司可对下属矿井所涉及的安全、生产、人员数据进行有效集成,达到在集团公司指挥中心实现远程监测、统一管理、集中调度的目标.文章对煤矿行业集团公司的信息化建设有很好的借鉴作用.%The paper described design and application status of integrated information networking platform for coal mine safety monitoring of Shanxi Liliu Coking Coal Group Co., Ltd.. Through the platform, coal enterprise group can effectively integrate data of mine security, production and personnel of affiliated mine and achieve the aim of remote monitoring, unitive management and integrated scheduling in command center of coal enterprise group. The paper provides some guidance for informatization construction of coal enterprise enterprise.

  2. A Study and Development of Chemical Process Integrated Operation System Platform%化工过程集成运行系统平台的研究与开发

    Institute of Scientific and Technical Information of China (English)

    李秀喜; 江燕斌; 钱宇

    2001-01-01

    采用人工智能辅助的研究方法,对于CIPS中工程技术的集成——计算机集成过程运行系统(CIPOS)的体系结构以及信息集成、知识/模型集成、工具集成的策略与技术等问题进行研究。介绍了CIPOS实验平台的结构和开发出的CIPOS原型系统,在Gensym的G2上开发了该原型系统的中央平台,初步实现了系统信息、方法集成和实时故障诊断功能。%Computer Integrated Process Operation System(CIPOS)is the major component of CIPS.In this paper,the strategy and technique of CIPOS is studied using artificial method,including the integration of system structure,information,knowledge/model,and tools.And the structure and prototype system of CIPOS experiment platform is introduced.The center platform of this prototype is developed on G2;the function of system information,integrated method and real-time fault diagnosis is basically implemented.

  3. Construction and Implementation of Rural Information Integrated Service Platform in Luohe%漯河市农村信息化综合服务平台构建与实施

    Institute of Scientific and Technical Information of China (English)

    高坡; 张冰; 宁松艳; 田晓远; 董高峰; 刘源源; 梁卜允

    2016-01-01

    农村信息化服务平台是建设社会主义新农村的重要手段,对农业技术的推广与应用有显著的叠加效应。通过构建与优化农村信息化综合服务平台,研究开发农业科技信息技术产品和多媒体信息系统,综合运用广播、电视及报刊杂志等传统信息传递方式,以及计算机、网络及卫星通讯等现代发达的信息技术,对现有信息传播体系进行集成整合,建立和完善农村科技信息化综合服务平台。%Rural information service platform is an important means to build socialist new countryside, which has significant superimposed effect on the popularization and application of agricultural technology. Through the establishment and optimization of rural information integrated service platform, this paper studied and developed a batch of agricultural science and technology information technology products and multimedia information system, and comprehensively applied traditional information transmission mode such as radio, television, newspapers, magazines and modern advanced information technology such as computer, network and satellite communications, to integrate the existing information dissemination system, establish and perfect rural information integrated service platform.

  4. Construction and Research on Construction of Jiangx Security Operation Integrated Provincial Local Taxation Information Systems Management Platform%江西地税安全运维管理平台的建设研究

    Institute of Scientific and Technical Information of China (English)

    周文星

    2012-01-01

    this article has mainly analyzed JiangXi Provincial Local Taxation information management problems that exist in Network security,and introduced Research and Practice on construction of Jiangxi Provincial Local Taxation Information Systems Security Operation Integrated Management Platform%文章主要分析了江西地税网络安全管理过程中存在的问题,就这些问题介绍了江西地税安全运维管理平台建设过程中的研究和实践。

  5. Pretreatment Engineering Platform (PEP) Integrated Test B Run Report--Caustic and Oxidative Leaching in UFP-VSL-T02A

    Energy Technology Data Exchange (ETDEWEB)

    Geeting, John GH; Bredt, Ofelia P.; Burns, Carolyn A.; Golovich, Elizabeth C.; Guzman-Leong, Consuelo E.; Josephson, Gary B.; Kurath, Dean E.; Sevigny, Gary J.; Aaberg, Rosanne L.

    2009-12-10

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed and operated as part of a plan to respond to issue M12, “Undemonstrated Leaching Processes” of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. The PEP also includes non-prototypic ancillary equipment to support the core processing.

  6. Application of an integrated LC-UV-MS-NMR platform to the identification of secondary metabolites from cell cultures: benzophenanthridine alkaloids from elicited Eschscholzia californica (california poppy) cell cultures().

    Science.gov (United States)

    Gathungu, Rose M; Oldham, John T; Bird, Susan S; Lee-Parsons, Carolyn W T; Vouros, Paul; Kautz, Roger

    2012-01-01

    Plant cell and tissue cultures are a scalable and controllable alternative to whole plants for obtaining natural products of medical relevance. Cultures can be optimized for high yields of desired metabolites using rapid profiling assays such as HPLC. We describe an approach to establishing a rapid assay for profiling cell culture expression systems using a novel microscale LC-UV-MS-NMR platform, designed to acquire both MS and NMR each at their optimal sensitivity, by using nanosplitter MS from 4 mm analytical HPLC columns, and offline microdroplet NMR. The approach is demonstrated in the analysis of elicited Eschscholzia californica cell cultures induced with purified yeast extract to produce benzophenanthridine alkaloids. Preliminary HPLC-UV provides an overview of the changes in the production of alkaloids with time after elicitation. At the time point corresponding to the production of the most alkaloids, the integrated LC-MS-microcoil NMR platform is used for structural identification of extracted alkaloids. Eight benzophenanthridine alkaloids were identified at the sub-microgram level. This paper demonstrates the utility of the nanosplitter LC-MS/microdroplet NMR platform when establishing cell culture expression systems.

  7. Integration of a platform based in field bus (profibus), for the development of process control systems; Integracion de una plataforma basada en bus de campo PROFIBUS, para el desarrollo de sistemas de control de procesos

    Energy Technology Data Exchange (ETDEWEB)

    Islas Perez, Eduardo; Arroyo Figueroa, Gustavo; Villavicencio Ramirez, Alejandro [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1994-03-01

    The integration of a computer platform for the process sequential control system development and validation of some processes of thermoelectric generation, which are constituted by operations of the logic-sequential type. The platform is composed of a process simulator, a sequence tester, a logic programmable controller, and an operational computer. All these elements are interconnected through a field bus type PROFIBUS (Process Field Bus) (Standard DIN 19245). This platform has been used for the elaboration and evaluation of the operational sequence and control of demineralization, reverse osmosis, and condensate polishing water treatment plants, which are simulated in a personal computer. [Espanol] Se presenta la integracion de una plataforma de computo para el desarrollo y validacion de sistemas de control secuencial de algunos procesos de generacion termoelectrica, los cuales estan constituidos por operaciones de tipo logico-secuencial. La plataforma esta compuesta por un simulador del proceso, un probador de secuencias, un controlador logico programable y una computadora de operacion. Todos estos elementos estan interconectados a traves de un bus de campo tipo PROFIBUS (Process Field Bus), (Estandar DIN 19245). Esta plataforma se ha utilizado para elaborar y validar la programacion de las secuencias de operacion y control de plantas de tratamiento de agua por desmineralizacion, osmosis inversa y pulidores de condensados, las cuales se tienen simuladas en una computadora personal

  8. Integrated Solution Research of Military Health Consultation Aiding Xinjiang and Local Telemedicine Platform%军队卫生援疆与地方远程医疗平台整合方案研究

    Institute of Scientific and Technical Information of China (English)

    王武化; 高山

    2016-01-01

    Objective: Integrate military and local telemedicine resources to design a normal operation and management platform for military and local hospitals. Method: On the basis of analyzing the military and locality telemedicine resources, this paper proposes remote medical management platform architecture of normalization operations, extend the function of existing locality telemedicine platform. Result: Design a telemedicine consultation system sharing for military hospital and 86 county hospitals in Xinjiang. Conclusion: Achieve the design and application of Military health consultation aiding Xinjiang platform, discuss the related issue.%目的:整合军地远程医疗资源,设计一套军民融合的远程医疗常态化运营管理平台。方法:在分析军地医疗机构远程医疗资源特点的基础上,提出了常态化运营的远程医疗管理平台架构,利用地方现有远程医疗平台进行功能扩展。结果:设计开发出军民共用部队医院卫生援疆86所县医院远程医疗会诊系统。结论:实现了军队医院开展卫生援疆远程医疗管理平台的设计应用,探讨了军民融合下军队医院对地方医疗机构开展医疗远程会诊的相关问题。

  9. Construction and application of information platform of saline soil improvement technology integration%盐渍化土壤改良技术集成信息化平台的建设及应用

    Institute of Scientific and Technical Information of China (English)

    冯琛; 解建仓; 孙博; 朱记伟; 汪妮

    2011-01-01

    【目的】建立盐渍化土壤改良技术集成信息化平台,为盐渍化土壤改良提供信息服务和决策依据。【方法】以渭南地区为研究对象,综合采用Java2平台企业版(J2EE)技术、遥感技术和地理信息系统与全球定位系统(3S)集成技术、高级应用框架(AAF)技术、数据库技术以及无线通讯技术,构建盐渍化土壤改良技术集成信息化平台,并对其主要功能进行分析。【结果】设计并构建了盐渍化土壤改良技术集成信息化平台,该平台不仅能够对盐渍化土壤的盐分分布及运移进行实时监控,而且可以针对该区域盐渍化的变化、分布和特点,筛选推荐对应的改良技术;同时,该平台具有无线应用系统——WAP移动门户的信息化服务功能,可通过无线手持设备访问应用数据和信息;此外,该平台还具有能反映不同地区盐渍化土壤时空演变的功能。【结论】构建的盐渍化土壤改良技术集成信息化平台,具有较强的操作性和适用性,提高了对盐渍化土壤改良技术集成应用的信息化、可视化、科学化和现代化,实现了土壤盐渍化监控和集成技术对盐渍化土壤改良的直接指导。%【Objective】 The information platform of saline soil improvement technology integration was constructed,aiming to improve saline soil to provide for information services and decision.【Method】 Taking Weinan region for study object,Java2 Platform-Enterprise Edition(J2EE) technology,Remote Sensing,Geographical information System,Global Positioning System(3S) integrated technology,Adcanced Application Framework(AAF) technology,database technology and wireless communication technology were used to construct,the information platform of saline soil improvement technology integration was built,and its main functions were analyzed.【Result】 The information platform of saline soil improvement technology integration was designed and

  10. Design of a numeric simulation platform for integrated turbo-shaft engine/helicopter control system%涡轴发动机/直升机综合控制仿真平台设计

    Institute of Scientific and Technical Information of China (English)

    张海波; 姚文荣; 陈国强

    2011-01-01

    A control simulation platform is designed for UH-60 helicopter /T700 turbo-shaft engine integrated system numeric simulation. The simulation platform includes two parts; host computer program and slave computer program, and they are both developed by VC ++ programming language. Host computer program is composed by UH-60 helicopter and T700 turbo-shaft engine real-time mathematical model, and the slave computer program simulates the embedded engine model and main rotor dynamic model,and carries out a variety of online optimization modes. The two programs above communicate with each other in real time based on TCP/IP protocol, so the transient and state process can be simulated for the integrated helicopter and engine system subjecting to surrounding and control parameters. Simulation results in some optimization control modes are also given throughout the simulation platform, respectively, including those which improve the helicopter traditional performance. The main rotor speed are kept constant or not, and the fast power-tracking mode can improve the helicopter maneuverability. All the simulation results show clearly that the simulation platform can provide an feasible validation in the early stage to implement an new integrated engine /helicopter control system.%建立了UH-60直升机/T700涡轴发动机综合控制数字仿真平台.基于VC++环境开发了包含UH-60直升机/T700涡轴发动机综合实时模型的上位机程序,与运行机载涡轴发动机+旋翼实时模型及在线优化控制模式的下位机程序.两者基于TCP/IP协议实时通讯,可进行模拟实际直/发综合优化控制的数字仿真实验.在该数字仿真环境下,分别给出了提高直升机常规飞行性能的多种优化控制模式仿真、变旋翼转速优化控制以及快速功率跟随控制模式仿真,充分表明该平台可为新一代直/发综合系统的开发研制提供一个可靠的前期数字仿真验证.

  11. Design and implementation of general integration platform based on structured P2P networks%通用的结构化P2P网络支撑平台的设计及实现

    Institute of Scientific and Technical Information of China (English)

    刘业; 刘林峰

    2013-01-01

    针对结构化P2P网络所拥有的可缩放特性,对基于结构化P2P网络技术在广域网范围内实现海量规模的资源整合和共享机制进行了研究.提出了一种通用的结构化P2P网络支撑平台,给出了结构化P2P网络支撑平台参考模型,并在该参考模型的指导下,设计出一种通用的结构化P2P网络支撑平台实现框架的模块划分图,同时介绍了通用平台的具体设计及实现,详细阐述了可提供给第三方进行新型应用开发的开放API接口函数,并给出了通用平台的相关测试结果.该文的工作对推动结构化P2P网络技术的实用化进程将提供有益的参考.%Considering that scalability is a fundamental property of structured P2P networks, the mechanism based on structured P2P networks is studied to make huge numbers of resources in the range of Internet integrate and share. A general integration platform based on structured P2P networks is proposed. Firstly, a layered reference model is given, in the guide of which an implementation framework of integration platform in constructed. Modules' functions in the frameworks are described individually. Detail design and implementation of the platform are discussed. Open API interface functions are elaborated in detail, which is provided to the third party to develop the new applications. Simulations are verified the platform's feature. These works have great reference value to the farther research.

  12. SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips

    Science.gov (United States)

    Vo-Dinh, Tuan

    2007-09-11

    A Raman integrated sensor system for the detection of targets including biotargets includes at least one sampling platform, at least one receptor probe disposed on the sampling platform, and an integrated circuit detector system communicably connected to the receptor. The sampling platform is preferably a Raman active surface-enhanced scattering (SERS) platform, wherein the Raman sensor is a SERS sensor. The receptors can include at least one protein receptor and at least one nucleic acid receptor.

  13. Overall Design of Integrated Information Management Platform Based on EIP System of SMS Enterprises%基于中小企业EIP系统的集成信息管理平台总体设计

    Institute of Scientific and Technical Information of China (English)

    方成民

    2012-01-01

    随着中小企业业务的发展及企业实际状况,构建起适合中小企业的基于EIP系统和统一认证中心、中心数据库的集成当今企业需要的如基础信息系统、ERP、OA、HR、CRM、DRP、SCM、DSS等功能于一身的多功能企业信息平台.企业通过平台还可实现对企业电子商务的整合,提高企业竞争力.%In this paper, we established the enterprise information platform based on the integration of the EIP system, unified authentication center and central database. Such platform had integrated the much-needed functions of fundamental information system, ERP, OA, HR, CRM, DRP, SCM, DSS, etc. and could help improve the competitiveness of the enterprise.

  14. 基于B/S模式的无纸化考试系统整合平台%The Paperless Examination System Integration Platform Based on B/S Mode

    Institute of Scientific and Technical Information of China (English)

    周卫忠

    2014-01-01

    随着现代化教育的高速发展、信息技术以及计算机网络技术在教育领域的不断推广和应用,无纸化考试系统应运而生。在考试系统越来越多的情况下一个自动化的整合性平台是非常必要的。该文简单介绍了如何基于B/S结构以ASP技术设计一个简易的整合性的平台。%With the rapid development of modern education, information technology and the further promotion of computer network technology in the field of education and application of paperless examination system arises at the historic moment. Un⁃der the condition of the examination system more and more an automated integration platform is very necessary. This article sim⁃ply introduces how to based on B/S structure with ASP technology to design a simple integrated platform.

  15. Measures of Biochemical Sociology

    Science.gov (United States)

    Snell, Joel; Marsh, Mitchell

    2008-01-01

    In a previous article, the authors introduced a new sub field in sociology that we labeled "biochemical sociology." We introduced the definition of a sociology that encompasses sociological measures, psychological measures, and biological indicators Snell & Marsh (2003). In this article, we want to demonstrate a research strategy that would assess…

  16. Biochemical Education in Brazil.

    Science.gov (United States)

    Vella, F.

    1988-01-01

    Described are discussions held concerning the problems of biochemical education in Brazil at a meeting of the Sociedade Brazileira de Bioquimica in April 1988. Also discussed are other visits that were made to universities in Brazil. Three major recommendations to improve the state of biochemistry education in Brazil are presented. (CW)

  17. Cots Correlator Platform

    Science.gov (United States)

    Schaaf, Kjeld; Overeem, Ruud

    2004-06-01

    Moore’s law is best exploited by using consumer market hardware. In particular, the gaming industry pushes the limit of processor performance thus reducing the cost per raw flop even faster than Moore’s law predicts. Next to the cost benefits of Common-Of-The-Shelf (COTS) processing resources, there is a rapidly growing experience pool in cluster based processing. The typical Beowulf cluster of PC’s supercomputers are well known. Multiple examples exists of specialised cluster computers based on more advanced server nodes or even gaming stations. All these cluster machines build upon the same knowledge about cluster software management, scheduling, middleware libraries and mathematical libraries. In this study, we have integrated COTS processing resources and cluster nodes into a very high performance processing platform suitable for streaming data applications, in particular to implement a correlator. The required processing power for the correlator in modern radio telescopes is in the range of the larger supercomputers, which motivates the usage of supercomputer technology. Raw processing power is provided by graphical processors and is combined with an Infiniband host bus adapter with integrated data stream handling logic. With this processing platform a scalable correlator can be built with continuously growing processing power at consumer market prices.

  18. The Research and Exploration of the Integration Platform of Hospital Information System Based on Ensemble%基于Ensemble的医院信息系统集成平台的研究与探索

    Institute of Scientific and Technical Information of China (English)

    曹茂诚; 陈旭; 何及夫; 牛启润

    2012-01-01

    目的:在医院内部信息系统集成方面,传统点对点接口通信模式存在系统耦合度高,系统整体稳定性和安全性难以预测和控制等隐患.不同业务系统之间难以实现数据交换与资源共享.如何打造一个稳定、高效、安全、可管理的集成平台,以满足不断变化的应用需求是一个亟待解决的问题.方法:将Ensemble集成平台技术引入到医院信息化建设中进行研究是一项非常有意义的工作,在分析传统点对点接口通信模式不足的基础上,文章结合Ensemble集成平台技术,建立了以病人为中心的统一视图,实现了跨平台的数据交换与共享.结果:通过Ensemble集成平台技术建立了以患者就诊流程为核心的内部信息共享交互平台,实现了全院数据交换与共享,消除了“信息孤岛”,实现了新业务应用的快速部署.结论:Ensemble集成平台技术为医院业务变革提供了灵活的、快速实施和部署的系统架构,实现了医疗信息的交换与共享,优化了服务流程,提高了医院运营效率,满足了医院信息化可持续发展.%Objective: In the integration of hospital internal information system, the traditional point to point interface of communication mode exist high coupling of systems, also have many hidden trouble in the stability and safety of global system that are hard to foresee and control. It is difficult to exchange data and share resource in different business systems. How to build a stable, efficient, safety and control integration to meet the changing application requirements is a problem to be solved imperatively. Methods: Introducing integration platform of ensemble into hospital information construction is a significant and valuable work, based on the deficiency of traditional point to point interface of communication mode, combined with integration platform of ensemble, contribute to build "patient-centered" unified view, realize the data exchange and resource

  19. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...

  20. A novel lab-on-chip platform with integrated solid phase PCR and Supercritical Angle Fluorescence (SAF) microlens array for highly sensitive and multiplexed pathogen detection.

    Science.gov (United States)

    Hung, Tran Quang; Chin, Wai Hoe; Sun, Yi; Wolff, Anders; Bang, Dang Duong

    2017-04-15

    Solid-phase PCR (SP-PCR) has become increasingly popular for molecular diagnosis and there have been a few attempts to incorporate SP-PCR into lab-on-a-chip (LOC) devices. However, their applicability for on-line diagnosis is hindered by the lack of sensitive and portable on-chip optical detection technology. In this paper, we addressed this challenge by combining the SP-PCR with super critical angle fluorescence (SAF) microlens array embedded in a microchip. We fabricated miniaturized SAF microlens array as part of a microfluidic chamber in thermoplastic material and performed multiplexed SP-PCR directly on top of the SAF microlens array. Attribute to the high fluorescence collection efficiency of the SAF microlens array, the SP-PCR assay on the LOC platform demonstrated a high sensitivity of 1.6 copies/µL, comparable to off-chip detection using conventional laser scanner. The combination of SP-PCR and SAF microlens array allows for on-chip highly sensitive and multiplexed pathogen detection with low-cost and compact optical components. The LOC platform would be widely used as a high-throughput biosensor to analyze food, clinical and environmental samples.

  1. Microfluidic Integration of a Cloth-Based Hybridization Array System (CHAS) for Rapid, Colorimetric Detection of Enterohemorrhagic Escherichia coli (EHEC) Using an Articulated, Centrifugal Platform.

    Science.gov (United States)

    Geissler, Matthias; Clime, Liviu; Hoa, Xuyen D; Morton, Keith J; Hébert, Harold; Poncelet, Lucas; Mounier, Maxence; Deschênes, Mylène; Gauthier, Martine E; Huszczynski, George; Corneau, Nathalie; Blais, Burton W; Veres, Teodor

    2015-10-20

    We describe the translation of a cloth-based hybridization array system (CHAS), a colorimetric DNA detection method that is used by food inspection laboratories for colony screening of pathogenic agents, onto a microfluidic chip format. We also introduce an articulated centrifugal platform with a novel fluid manipulation concept based on changes in the orientation of the chip with respect to the centrifugal force field to time the passage of multiple components required for the process. The platform features two movable and motorized carriers that can be reoriented on demand between 0 and 360° during stage rotation. Articulation of the chip can be used to trigger on-the-fly fluid dispensing through independently addressable siphon structures or to relocate solutions against the centrifugal force field, making them newly accessible for downstream transfer. With the microfluidic CHAS, we achieved significant reduction in the size of the cloth substrate as well as the volume of reagents and wash solutions. Both the chip design and the operational protocol were optimized to perform the entire process in a reliable, fully automated fashion. A demonstration with PCR-amplified genomic DNA confirms on-chip detection and identification of Escherichia coli O157:H7 from colony isolates in a colorimetric multiplex assay using rfbO157, fliCH7, vt1, and vt2 genes.

  2. DockBench: An Integrated Informatic Platform Bridging the Gap between the Robust Validation of Docking Protocols and Virtual Screening Simulations

    Directory of Open Access Journals (Sweden)

    Alberto Cuzzolin

    2015-05-01

    Full Text Available Virtual screening (VS is a computational methodology that streamlines the drug discovery process by reducing costs and required resources through the in silico identification of potential drug candidates. Structure-based VS (SBVS exploits knowledge about the three-dimensional (3D structure of protein targets and uses the docking methodology as search engine for novel hits. The success of a SBVS campaign strongly depends upon the accuracy of the docking protocol used to select the candidates from large chemical libraries. The identification of suitable protocols is therefore a crucial step in the setup of SBVS experiments. Carrying out extensive benchmark studies, however, is usually a tangled task that requires users’ proficiency in handling different file formats and philosophies at the basis of the plethora of existing software packages. We present here DockBench 1.0, a platform available free of charge that eases the pipeline by automating the entire procedure, from docking benchmark to VS setups. In its current implementation, DockBench 1.0 handles seven docking software packages and offers the possibility to test up to seventeen different protocols. The main features of our platform are presented here and the results of the benchmark study of human Checkpoint kinase 1 (hChk1 are discussed as validation test.

  3. Long-Term Outdoor Reliability Assessment of a Wireless Unit for Air-Quality Monitoring Based on Nanostructured Films Integrated on Micromachined Platforms

    Directory of Open Access Journals (Sweden)

    Massimiliano Decarli

    2012-06-01

    Full Text Available We have fabricated and tested in long-term field operating conditions a wireless unit for outdoor air quality monitoring. The unit is equipped with two multiparametric sensors, one miniaturized thermo-hygrometer, front-end analogical and digital electronics, and an IEEE 802.15.4 based module for wireless data transmission. Micromachined platforms were functionalized with nanoporous metal-oxides to obtain multiparametric sensors, hosting gas-sensitive, anemometric and temperature transducers. Nanoporous metal-oxide layer was directly deposited on gas sensing regions of micromachined platform batches by hard-mask patterned supersonic cluster beam deposition. An outdoor, roadside experiment was arranged in downtown Milan (Italy, where one wireless sensing unit was continuously operated side by side with standard gas chromatographic instrumentation for air quality measurements. By means of a router PC, data from sensing unit and other instrumentation were collected, merged, and sent to a remote data storage server, through an UMTS device. The whole-system robustness as well as sensor dataset characteristics were continuously characterized over a run-time period of 18 months.

  4. The Geohazards Exploitation Platform

    Science.gov (United States)

    Laur, Henri; Casu, Francesco; Bally, Philippe; Caumont, Hervé; Pinto, Salvatore

    2016-04-01

    The Geohazards Exploitation Platform, or Geohazards TEP (GEP), is an ESA originated R&D activity of the EO ground segment to demonstrate the benefit of new technologies for large scale processing of EO data. This encompasses on-demand processing for specific user needs, systematic processing to address common information needs of the geohazards community, and integration of newly developed processors for scientists and other expert users. The platform supports the geohazards community's objectives as defined in the context of the International Forum on Satellite EO and Geohazards organised by ESA and GEO in Santorini in 2012. The GEP is a follow on to the Supersites Exploitation Platform (SSEP) an ESA initiative to support the Geohazards Supersites & Natural Laboratories initiative (GSNL). Today the GEP allows to exploit 70+ Terabyte of ERS and ENVISAT archive and the Copernicus Sentinel-1 data available on line. The platform has already engaged 22 European early adopters in a validation activity initiated in March 2015. Since September, this validation has reached 29 single user projects. Each project is concerned with either integrating an application, running on demand processing or systematically generating a product collection using an application available in the platform. The users primarily include 15 geoscience centres and universities based in Europe: British Geological Survey (UK), University of Leeds (UK), University College London (UK), ETH University of Zurich (CH), INGV (IT), CNR-IREA and CNR-IRPI (IT), University of L'Aquila (IT), NOA (GR), Univ. Blaise Pascal & CNRS (FR), Ecole Normale Supérieure (FR), ISTERRE / University of Grenoble-Alpes (FR). In addition, there are users from Africa and North America with the University of Rabat (MA) and the University of Miami (US). Furthermore two space agencies and four private companies are involved: the German Space Research Centre DLR (DE), the European Space Agency (ESA), Altamira Information (ES

  5. 供应链一体化下物流电子商务平台的构建研究%Study on the Construction of Logistics E-commerce Platform under the Integration of Supply Chain

    Institute of Scientific and Technical Information of China (English)

    李国刚; 张萌萌

    2015-01-01

    电子商务的快速发展使得物流服务“瓶颈”束缚问题越加凸显。在此背景下提出基于社会资源整合的供应链一体化的机制,将物流视为一般商品进行电子商务,对供应链一体化下基于社会资源整合的物流电子商务公共服务平台进行了具体分析。%The development of e-commerce makes the "bottleneck" problem of logistics service more highlighted. Under the background, this paper puts forward the mechanism of supply chain integration which is based on social resources integration, takes logistics as general e-commerce merchandise to study the public service platform of logistics e-commerce which is based on social resources integration under the supply chain integration.

  6. 教学产业园是高职教育资源有效整合的平台%Teaching industrial park is the platform for integrating resources of higher vocational education effectively

    Institute of Scientific and Technical Information of China (English)

    顾准

    2014-01-01

    Starting from connotation of higher vocational education resources and effective integration, this paper discusses the practical significances of integration of higher vocational education resources such as solving insufficiency problem of resources,promoting school - enterprise cooperation,accelerating government support and realizing region share.Based on analyzing the advantages of teaching industrial park as the platform for integrating resources of higher vocational education effectively,this paper puts forward strategies such as striving for government resources,integrating college and enterprise re-sources,optimizing manpower resources and constructing teaching resources.%从高职教育资源及有效整合的内涵入手,探讨了高职教育资源整合解决资源不足、推动校企合作、促进政府支持、实现区域共享的现实意义。在分析教学产业园作为高职教育有效整合平台所具备的有利条件基础上,提出了依托教学产业园争取政府资源、整合校企资源、优化人力资源、建设教学资源等策略。

  7. Integrated Management System of Oilfield Exploitation and Development Based on WebGIS Platform%基于 WebGIS 平台的油田勘探开发一体化综合管理系统

    Institute of Scientific and Technical Information of China (English)

    郭杰; 薛欢庆; 徐惠; 苏倩

    2015-01-01

    利用 WebGIS 平台的可扩展性和跨平台的特点,借助专用的3D 展示模块,将油藏开发中地震解释、测井解释、地质建模、油藏数值模拟等成果进行集中的加载与展示,实现了上游多学科研究成果的共享;同时,工程师可以从该系统获取所需资料并提交研究成果与工程数据。在 WebGIS 平台下还实现了井位辅助优化功能,减轻了因剩余油分布“高度分散、局部富集”导致的均匀井网生产效率低下的问题。借助平台的子系统,也实现了多学科在同一平台下工作方案,达到了对油藏从勘探到开发的一体化综合管理。%Through utilizing the properties of ductility and cross-platform of WebGIS software platform, the results of reservoir exploitation, such as seismic interpretation, well logging interpretation, geologic modeling, numerical reservoir simulation, were intensively loaded and displayed by using 3D display module, which could realize the sharing of multi-disciplinary research results. In the meantime, engineers could gain information from this system and submit the study results and engineering data. By using WebGIS software platform, the function of optimizing well's locating could be also realized to solve the problem of low rate of well pattern production caused by the high dispersion and local accumulation distribution of remaining oil. Through using the subsystem of the platform, multidisciplinary work under the same platform could be realized to reach integration management of reservoir exploitation and development.

  8. 计算机集成激光三维增材成形制造平台%Laser Three-dimensional Additive Forming Manufacturing Platform by Computer Integrating for LCD-SLM-SLS

    Institute of Scientific and Technical Information of China (English)

    颜永年; 荆红; 张定军; 陈振东

    2014-01-01

    将激光熔覆沉积(LCD)和选择性激光熔化/烧结(SLM/S)两类最重要的金属增材成形技术中的CAD模型、分层与路径规划、工艺参数和激光使能系统等相关信息和异构数据,通过采用CIMS的技术原理和系统集成方法,构建了L-SS(LCD-SLM/S)激光增材成形平台,实现了在计算机管控下,将信息数据资源与多台3D打印设备、激光器的优化配置,大大提高了信息共享度、资源利用率和节能效率。%LCD (laser cladding deposition) and SLM/S (selective laser melting/sintering) are two kinds of the most important metal addictive forming technologies. In the paper ,it was proposed that the Laser addictive forming platform was built based on all information and heterogeneous data about the CAD model,layering,path planning,parameters of process and Laser System by using the technology principle and system integration methods of CIMS (computer integrated manufacturing system). The L-SS (LCD-SLM/S) platform integrates all data ,optimizes 3D-printer and laser devices under the control of computer and greatly improves the degree of information sharing ,the ratio of information utilization and energy efficiency.

  9. SU-E-J-04: Integration of Interstitial High Intensity Therapeutic Ultrasound Applicators On a Clinical MRI-Guided High Intensity Focused Ultrasound Treatment Planning Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, N [Johns Hopkins University, Baltimore, Maryland (United States); Partanen, A [Philips Healthcare, Andover, Massachusetts (United States); Ghoshal, G; Burdette, E [Acoustic MedSystems Inc., Savoy, IL (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: Interstitial high intensity therapeutic ultrasound (HITU) applicators can be used to ablate tissue percutaneously, allowing for minimally-invasive treatment without ionizing radiation [1,2]. The purpose of this study was to evaluate the feasibility and usability of combining multielement interstitial HITU applicators with a clinical magnetic resonance imaging (MRI)-guided focused ultrasound software platform. Methods: The Sonalleve software platform (Philips Healthcare, Vantaa, Finland) combines anatomical MRI for target selection and multi-planar MRI thermometry to provide real-time temperature information. The MRI-compatible interstitial US applicators (Acoustic MedSystems, Savoy, IL, USA) had 1–4 cylindrical US elements, each 1 cm long with either 180° or 360° of active surface. Each applicator (4 Fr diameter, enclosed within a 13 Fr flexible catheter) was inserted into a tissue-mimicking agar-silica phantom. Degassed water was circulated around the transducers for cooling and coupling. Based on the location of the applicator, a virtual transducer overlay was added to the software to assist targeting and to allow automatic thermometry slice placement. The phantom was sonicated at 7 MHz for 5 minutes with 6–8 W of acoustic power for each element. MR thermometry data were collected during and after sonication. Results: Preliminary testing indicated that the applicator location could be identified in the planning images and the transducer locations predicted within 1 mm accuracy using the overlay. Ablation zones (thermal dose ≥ 240 CEM43) for 2 active, adjacent US elements ranged from 18 mm × 24 mm (width × length) to 25 mm × 25 mm for the 6 W and 8 W sonications, respectively. Conclusion: The combination of interstitial HITU applicators and this software platform holds promise for novel approaches in minimally-invasive MRI-guided therapy, especially when bony structures or air-filled cavities may preclude extracorporeal HIFU.[1] Diederich et al

  10. Multiplexing oscillatory biochemical signals.

    Science.gov (United States)

    de Ronde, Wiet; ten Wolde, Pieter Rein

    2014-04-01

    In recent years it has been increasingly recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier. Moreover, it is now well established that the protein signaling network of living cells has a bow-tie structure and that components are often shared between different signaling pathways. Here we show by mathematical modeling that living cells can multiplex a constant and an oscillatory signal: they can transmit these two signals simultaneously through a common signaling pathway, and yet respond to them specifically and reliably. We find that information transmission is reduced not only by noise arising from the intrinsic stochasticity of biochemical reactions, but also by crosstalk between the different channels. Yet, under biologically relevant conditions more than 2 bits of information can be transmitted per channel, even when the two signals are transmitted simultaneously. These observations suggest that oscillatory signals are ideal for multiplexing signals.

  11. A novel lab-on-chip platform with integrated solid phase PCR and Supercritical Angle Fluorescence (SAF) microlens array for highly sensitive and multiplexed pathogen detection

    DEFF Research Database (Denmark)

    Hung, Tran Quang; Chin, Wai Hoe; Sun, Yi

    2016-01-01

    directly on top of the SAF microlens array. Attribute to the high fluorescence collection efficiency of the SAF microlens array, the SP-PCR assay on the LOC platform demonstrated a high sensitivity of 1.6 copies/µL, comparable to off-chip detection using conventional laser scanner. The combination of SP-PCR......Solid-phase PCR (SP-PCR) has become increasingly popular for molecular diagnosis and there have been a few attempts to incorporate SP-PCR into lab-on-a-chip (LOC) devices. However, their applicability for on-line diagnosis is hindered by the lack of sensitive and portable on-chip optical detection...... technology. In this paper, we addressed this challenge by combining the SP-PCR with super critical angle fluorescence (SAF) microlens array embedded in a microchip. We fabricated miniaturized SAF microlens array as part of a microfluidic chamber in thermoplastic material and performed multiplexed SP-PCR...

  12. An Intelligent Automation Platform for Rapid Bioprocess Design.

    Science.gov (United States)

    Wu, Tianyi; Zhou, Yuhong

    2014-08-01

    Bioprocess development is very labor intensive, requiring many experiments to characterize each unit operation in the process sequence to achieve product safety and process efficiency. Recent advances in microscale biochemical engineering have led to automated experimentation. A process design workflow is implemented sequentially in which (1) a liquid-handling system performs high-throughput wet lab experiments, (2) standalone analysis devices detect the data, and (3) specific software is used for data analysis and experiment design given the user's inputs. We report an intelligent automation platform that integrates these three activities to enhance the efficiency of such a workflow. A multiagent intelligent architecture has been developed incorporating agent communication to perform the tasks automatically. The key contribution of this work is the automation of data analysis and experiment design and also the ability to generate scripts to run the experiments automatically, allowing the elimination of human involvement. A first-generation prototype has been established and demonstrated through lysozyme precipitation process design. All procedures in the case study have been fully automated through an intelligent automation platform. The realization of automated data analysis and experiment design, and automated script programming for experimental procedures has the potential to increase lab productivity.

  13. 基于云计算的煤矿物联网一体化平台体系架构%Integrated Platform System Framework of Mine Internet of Things Based on Cloud Computation

    Institute of Scientific and Technical Information of China (English)

    裴忠民; 李波; 徐硕; 朱华

    2012-01-01

    在总结煤矿安全生产管理信息系统发展历程的基础上,着眼于物联网、云计算等技术在煤矿领域的应用发展,提出了煤矿物联网一体化信息平台的概念,并对其特征进行了详细阐述;基于分层设计理念,给出了包含感知层、通信传输层、信息服务层和应用层4层结构的煤矿物联网一体化信息平台体系架构,介绍了每层结构的功能和组成。在此基础上,重点阐述了构建煤矿物联网一体化信息平台所涉及的现场感知与自组网、短距离无线通信、智能信息处理与服务、防爆设计等关键技术问题。%Based on the summarization of the development experiences in the mine safety production and management information system, looking at the application development of the internet of things, the cloud computation and other technology to the coal mines, an integrat-ed information platform conception of the mine internet of things was provided and the features were stated in detail. Based on the slicing design eonception, the integrated information platform system framework of the mine internet of things including the perception layer, com- munication and transmission layer, information services layer and application layer structures was provided. The paper introduced the function and composition of the each structure. Base the circumstances, the paper stressed the site perception and self organized network, short distance wireless communication, intelligent information processing and services, flame proof design and other key technical prob-lems related to the establishment on the integrated information platform of the mine internet of things.

  14. Optical Slot-Waveguide Based Biochemical Sensors

    Directory of Open Access Journals (Sweden)

    Carlos Angulo Barrios

    2009-06-01

    Full Text Available Slot-waveguides allow light to be guided and strongly confined inside a nanometer-scale region of low refractive index. Thus stronger light-analyte interaction can be obtained as compared to that achievable by a conventional waveguide, in which the propagating beam is confined to the high-refractive-index core of the waveguide. In addition, slot-waveguides can be fabricated by employing CMOS compatible materials and technology, enabling miniaturization, integration with electronic, photonic and fluidic components in a chip, and mass production. These advantages have made the use of slot-waveguides for highly sensitive biochemical optical integrated sensors an emerging field. In this paper, recent achievements in slot-waveguide based biochemical sensing will be reviewed. These include slot-waveguide ring resonator based refractometric label-free biosensors, label-based optical sensing, and nano-opto-mechanical sensors.

  15. Study of interfacial phenomena for bio/chemical sensing applications

    Science.gov (United States)

    Min, Hwall

    This work presents the fundamental study of biological and chemical interfacial phenomena and (bio)chemical sensing applications using high frequency resonator arrays. To realize a versatile (bio)chemical sensing system for the fundamental study as well as their practical applications, the following three distinct components were studied and developed: i) detection platforms with high sensitivity, ii) novel innovative sensing materials with high selectivity, iii) analytical model for data interpretation. 8-pixel micromachined quartz crystal resonator (muQCR) arrays with a fundamental resonance frequency of 60 ¡V 90 MHz have been used to provide a reliable detection platform with high sensitivity. Room temperature ionic liquid (RTIL) has been explored and integrated into the sensing system as a smart chemical sensing material. The use of nanoporous gold (np-Au) enables the combination of the resonator and surface-enhanced Raman spectroscopy for both quantitative and qualitative measurement. A statistical model for the characterization of resonator behavior to study the protein adsorption kinetics is developed by random sequential adsorption (RSA) approach with the integration of an effective surface depletion theory. The investigation of the adsorption kinetics of blood proteins is reported as the fundamental study of biological phenomena using the proposed sensing system. The aim of this work is to study different aspects of protein adsorption and kinetics of adsorption process with blood proteins on different surfaces. We specifically focus on surface depletion effect in conjunction with the RSA model to explain the observed adsorption isotherm characteristics. A number of case studies on protein adsorption conducted using the proposed sensing system has been discussed. Effort is specifically made to understand adsorption kinetics, and the effect of surface on the adsorption process as well as the properties of the adsorbed protein layer. The second half of the

  16. Reinventing the Platform Core Through Acquisition

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan; Eaton, Ben

    2016-01-01

    Digital platform leaders need to continuously innovate the platform core to drive the technological trajectory of the overall architecture and business system, of which the platform is a core element. This papers analyses the potential of and challenges to completing this task through...... the acquisition and integration of companies presenting innovative technologies of relevance to the platform core. Using a revelatory case study of Cisco Systems, we develop the explanatory notion of ‘coring acquisition’. In this type of acquisition value is created through the acquisition of companies...... that provide products external to the acquirer that can be assimilated into the platform core. This creates value through the transformational process that we term ‘coring’. We also analyze how the benefits of coring acquisitions are contingent on challenges concerning the integration of acquisitions offering...

  17. Research on Integration Model Based on Localization 4 PL Platform%基于本土化第四方物流平台的整合模型研究

    Institute of Scientific and Technical Information of China (English)

    黄林山

    2014-01-01

    经济的高速增长推动着物流的快速发展,第四方物流由于缺少本土化平台建设,导致物流成本居高不下,应当对现有物流体系进行整合,构建基于本土化的第四方物流平台,才能从根本上解决当前我国第四方物流运行中的不足,提高物流效率,降低物流成本,保持物流业的可持续发展。%High-speed economic growth promotes the rapid development of logistics .However,the lack of building the 4PL a localization platform,which still leads to a high cost of logistics .Therefore,we shall integrate the existing logistics system and establish the localization platform of 4PL,so that the problems of 4PL operating of our country can be fundamentally solved , as well as the efficiency of logistics will be improved ,the cost of logistics would be reduced and the sustainable development of logistics can be maintained .

  18. 军民融合区域协同医疗信息化平台的建设与应用%Construction and Application of Regional Health Information Platform for Civil-military Integration

    Institute of Scientific and Technical Information of China (English)

    应可满; 王继伟; 许树根

    2011-01-01

    军民融合区域协同医疗信息化平台的主要功能包括公众服务、医疗机构协同、社区卫生保健、妇幼保健、政府管理决策支持及第三方服务等.信息化平台的应用有效缓解了"看病难、看病贵"的矛盾,推动了医疗卫生机构的发展,强化了卫生行政部门的监管职能,促进了军队卫生事业的发展.%Main functions of regional health information platform for civil-military integration are described, which are public service, medical institutes' coordination, health care in community, material and child hygiene, support of government management policy and the third-party service, etc.Meanwhile, the application of information platform easing the contradictions of the “medical treatment is difficult and expensive” promotes the development of health care institutions, strengthens the regulatory functions of the health administration department, and promotes construction and development of the military health.

  19. The Application and Design of the Intelligent Knowledge Integration Platform in the Cable TV Service Window%智能知识融合平台在有线电视服务窗口的应用设计

    Institute of Scientific and Technical Information of China (English)

    招浩勉

    2016-01-01

    The intelligent knowledge integration platform realizes to provide business support services for serv-ice windows and offer intelligent business knowledge for cutomer service staff.At the same time,it supports the display of customers'wechat,text messages,network hall,APP and other service methods in the front end and outputs business information for users.The application of this platform achieves the effective improvement of the service responding effeciency and interactive experience.%通过智能知识融合平台,实现面向服务窗口的业务知识支撑服务,为客服中心座席人员提供智能化的业务知识,同时支持前端客户微信、短信、网厅、APP等服务渠道的展示,也为用户输出业务知识信息。这一平台的应用,实现了服务响应效率与服务交互体验的有效提升。

  20. Towards a Service-Oriented Enterprise: The Design of a Cloud Business Integration Platform in a Medium-Sized Manufacturing Enterprise

    Science.gov (United States)

    Stamas, Paul J.

    2013-01-01

    This case study research followed the two-year transition of a medium-sized manufacturing firm towards a service-oriented enterprise. A service-oriented enterprise is an emerging architecture of the firm that leverages the paradigm of services computing to integrate the capabilities of the firm with the complementary competencies of business…

  1. Optimization of a Common Buffer Platform for Monolithic Integration of InGaN/GaN Light-Emitting Diodes and AlGaN/GaN High-Electron-Mobility Transistors

    Science.gov (United States)

    Liu, Chao; Cai, Yuefei; Jiang, Huaxing; Lau, Kei May

    2016-04-01

    For the development of a metal-interconnection-free integration scheme for monolithic integration of InGaN/GaN light-emitting diodes (LEDs) and AlGaN/GaN high-electron-mobility transistors (HEMTs), a common buffer to achieve high brightness, low leakage current, and high breakdown in the integrated HEMT-LED device is essential. Different buffer structures have been investigated, and their impacts upon both the LED and HEMT parts of the HEMT-LED device have been analyzed. Results indicated that a GaN/AlN buffer structure is the most ideal to serve as a common buffer platform, offering both the excellent crystalline quality and superior buffer resistivity required by the HEMT-LED device. Growth of the AlN layer was particularly crucial for engineering the dislocation density, surface morphology, as well as resistivity of the buffer layer. Using the optimized GaN/AlN buffer structure, the LED part of the HEMT-LED device was improved, showing greatly enhanced light output power and suppressed reverse leakage current, while the breakdown characteristics of the HEMT part were also improved.

  2. 基于Web技术的一体化实践教学平台的设计%Design of Integration Practice Teaching Platform Based on the Web Technology

    Institute of Scientific and Technical Information of China (English)

    于丽梅; 于东敏; 李艳萍

    2012-01-01

    根据实践教学在高等教育中的重要性,研究开发一套基于Web技术的一体化实践教学平台,有效解决了高校实践教学中的实际问题,提高了实践教学质量,同时为培养学生实际应用能力及创新能力奠定了良好的基础。%According to the importance of the practice teaching in higher education, research and develop an integration practice teaching platform based on the Web technology. And it effectively resolves the practical problems in practice teaching, improves teaching quality, and at the same time it lays a good foundation for cultivating students' practical ability and innovation ability.

  3. 省市县一体化有序用电管理平台搭建%Integration Orderly Power Management Platform of Provinces Cities and Counties Building

    Institute of Scientific and Technical Information of China (English)

    仇德贵

    2012-01-01

    This thesis,through building the structure of province,city and county integration orderly power management platform,describes how to achieve order,comprehensive,standardized,auto and scientific management from four aspects: index management,program development,effect evaluation and inquiry,so as to effectively enhance the orderly power consumption levels.%通过搭建省、市、县一体化有序用电管理平台,从指标管理、方案制定、效果评价和综合查询等几个方面阐述了如何实现有序用电全面化、规范化、自动化和科学化的管理,从而有效提升有序用电管理工作水平。

  4. Design and Implementation of Distributed Integration and Data Transmission Platform%分布式一体化及数据交换平台的设计与实现

    Institute of Scientific and Technical Information of China (English)

    房成萍; 马坤; 杨波; 陈贞翔

    2011-01-01

    基于SOA、Web 服务和简单对象传输协议,对山东省学位与研究生教育管理信息系统的数据传输交换方式加以改进,解决了以往系统只能由高校端主动向中心端上报数据的弊端,使得中心端可以更加全面方便地对各高校端进行集中控制,形成一体化.在此基础上,提出一个面向分布式异构环境的数据传输交换平台的系统架构和实现方案,改进了传统数据传输交换平台的扩展性、通用性及数据安全性.%This paper improves on the way of data transmission between the center of education office and schools for the project of degree and postgraduate education management information system of Shandong province based on SOA, Web Service and SOAP protocol,which solves the problems that only school can transmit data to the center of education office actively and forms distributed integration.Furthermore, it brings the education office much more convenience for controlling schools.On the basis of the distributed integration, a platform for heterogeneous environment is also design ed to implement the incremental data transmission which improves the expausibility ,universal property and security of the former information exchange platform.

  5. Research on the Integrated Platform Architecture of Comprehensive Logging Information Gathering in Oil and Gas Fields%油气田综合录井信息采集一体化平台的体系结构研究

    Institute of Scientific and Technical Information of China (English)

    杨力; 廖浩德; 曹谢东; 刘增良

    2012-01-01

    通过分析现代综合录井信息化发展趋势,结合油气勘探开发的实际,针对现有录井远程监控体系的不足,运用现代传感器、自动化、计算机及通信技术,提出了新一代综合录井信息采集一体化平台体系结构.详细阐述了基于RTU的多传感器融合的井场无线局域数据中心,基于IPSTAR卫星及3G+APN+VPN的无线安全传输通道及井场与远程数据中心实时联动平台,详细分析了涉及的四大关键技术,为综合录井信息一体化建设和数字井场的物联网发展提供了新的方法和手段.%By analyzing the development trend of modern comprehensive logging information systems, combined with practical exploration and development of oil and gas, aiming at the shortcomings of the existing remote well-logging monitoring systems and application of modem sensors, automation, computer and communications technologies, a new integrated architecture of the comprehensive logging information collection platform is put forward. First, the wireless local area data center based on multi-sensor fusion RTU, wireless security transmission channel based on the IPSTAR satellite and 3G + VPN and real-time interaction platform between well field and remote data center are discussed in detail. Second,four key technologies are analyzed in detail and finally a new means is provided for the construction of comprehensive logging information integration and application of the Internet of things to digital well field.

  6. 基于BIM平台的集成化可持续建筑设计教学研究%A Study of the Teaching of Integrated Sustainable Building Design Based on the BIM Platform

    Institute of Scientific and Technical Information of China (English)

    解明镜; 石磊; 罗明

    2012-01-01

    通过对我国建筑设计教育现状的分析,指出基于线性设计模式和单一学科平台的教育模式已不能满足可持续建筑设计需求,基于集成化设计模式和跨学科设计平台的教学方式更适应社会的需求和学生设计能力的培养,而BIM平台能够为集成化设计模式提供软件平台,满足教学要求。通过在教学团队、教学方法、教学内容和教学时间上的改进与实践,教学改革收到良好效果,学生设计能力与专业内认可程度都有较大提高,在全国学科竞赛中成绩优异。%Based on the analysis of the status of architectural education, the liner design model and the singleness disciplinary educational model are founded unsuitable for the requirements of sustainable building design. The new teaching pattern, based on the integrated design model and multi-disciplinary design platform, is more effective for the design capacity training of undergraduates. BIM (Building information model) can afford the software platform for the integrated design model and meet the requirements of the society. By the improvements and practices on the teaching methodology, contents, teaching team and teaching time, the teaching reformation is successful. The design capacity of the undergraduates is improved, and many students win the awards from the national course contests.

  7. Three-dimensional system integration for HUD placement on a new tactical airlift platform: design eye point vs. HUD eye box with accommodation and perceptual implications

    Science.gov (United States)

    Harbour, Steven D.; Hudson, Jeffery A.; Zehner, Gregory F.

    2012-06-01

    The retrofitting of a cockpit with a Head-Up-Display (HUD) raises potential accommodation and perceptual issues for pilots that must be addressed. For maximum optical efficiency, the goal is to be able to place every pilot's eye into the HUD Eye Motion Box (EMB) given a seat adjustment range. Initially, the Eye Reference Point (ERP) of the EMB should theoretically be located on the aircraft's original cockpit Design Eye Point (DEP), but human postures vary, and HUD systems may not be optimally placed. In reality, there is a distribution of pilot eyes around the DEP (which is dominant eye dependent); therefore, this must be accounted for in order to obtain appropriate visibility of all of the symbology based on photonic characteristics of the HUD. Pilot size and postural variation need to be taken into consideration when positioning the HUD system to ensure proper vision of all HUD symbology in addition to meeting the basic physical accommodation requirements of the cockpit. The innovative process and data collection methods for maximizing accommodation and pilot perception on a new "tactical airlift" platform are discussed as well as the related neurocognitive factors and the effects of information display design on cognitive phenomena.

  8. Design on Water Industry Automation System Integration Platform in Urumqi%乌鲁木齐市水业自动化系统集成平台设计探讨

    Institute of Scientific and Technical Information of China (English)

    张润杰

    2012-01-01

      为实现乌鲁木齐市水利信息化和现代化,在结合 C/S、B/S 架构的基础上,采用 SOA架构,利用计算机网络自动化技术,将已经、正在和筹备建设的水利自动化系统工程无缝对接,形成包括源水管理、供水管理和安全保障等3个自动化系统的乌鲁木齐市水业自动化系统集成支撑平台。着重阐述安全保障自动化系统的各子系统的构建、实现功能,结合 GIS 地理信息平台进行开发,为洪水灾害预警、大坝安全监测提供几种解决方案,并尝试进行洪水风险图制作和管理。通过集成支撑平台的建设,将提升乌鲁木齐市水业集团对乌鲁木齐的水源和供水等城市水务管理能力,为乌鲁木齐市的经济与城市发展提供保障。%  To realize water resource information and modernization in Urumqi, based on combining with structures of C/S and B/S, water resource automation systems including already built, under construction and preparation for construction are of no-slot joint by SOA frame and computer network automation technology. Water industry automation system integration support platform of Urumqi is formed by three automatic systems: the source water management, water supply management and security control. The paper focuses on structuring and implementing functions of each subsystem in the security automation system. It is developed by combined with GIS geographic information platform. Several solutions are provided for flood disaster warning and dam safety monitoring. And it tries to produce and manage flood risking map. Through integrated support platform construction, urban water affairs management ability of waterhead and water supply management are promoted to ensure economic and urban development in Urumqi.

  9. 供电企业一体化缴费技术管理平台研究%The research of electricity payment technology integration management platform for power supply companies

    Institute of Scientific and Technical Information of China (English)

    房文平

    2015-01-01

    According to the"integrated payment access sys⁃tem" construction standards and multi⁃channel payment services business integration uniform requirements which are promulgated by the China Southern Power Grid Corporation, the integrated pay⁃ment technology management platform has been established that can meet the requirement of"one⁃stop service"marketing business applications. The SOA service⁃oriented layer architecture design scheme, the 95598 online banking, the electricity POS payment ter⁃minals, the power self⁃service payment terminals, online banking and other payment channels have been unified. The platform satis⁃fies the user electricity payment’s network, electronic, and conve⁃nient payment needs. The practice application of integrated pay⁃ment systems, can reduce the power supply enterprise operational services pressure, and improve the power marketing business de⁃velopment and human services levels, which can obtain win⁃win re⁃sults between the power companies and users benefits.%针对南方电网公司“一体化缴费接入系统”建设标准及多渠道缴费服务业务集成统一要求,建立符合“一站妥”营销业务应用需求的缴费技术管理平台。采用面向服务的SOA分层架构设计方案,将95598网上银行、电力POS缴费终端、电力自助缴费终端、网上银行等缴费渠道统一集成,实现用户网络化、电子化、便捷化等缴费需求。一体化缴费系统的运用,减轻了供电企业电力运营服务压力,提高了电力营销业务拓展和人性化服务水平,取得供电企业和用户利益的双赢效果。

  10. Product Platform Modeling

    DEFF Research Database (Denmark)

    Pedersen, Rasmus

    on the notion that reuse and encapsulation of platform elements are fundamental characteristics of a product platform. Reuse covers the desire to reuse and share certain assets across a family of products and/or across generations of products. Product design solutions and principles are often regarded...... as important assets in a product platform, yet activities, working patterns, processes and knowledge can also be reused in a platform approach. Encapsulation is seen as a process in which the different elements of a platform are grouped into well defined and self-contained units which are decoupled from each......This PhD thesis has the title Product Platform Modelling. The thesis is about product platforms and visual product platform modelling. Product platforms have gained an increasing attention in industry and academia in the past decade. The reasons are many, yet the increasing globalisation...

  11. Biochemical Hypermedia: Galactose Metabolism.

    Directory of Open Access Journals (Sweden)

    J.K. Sugai

    2013-05-01

    Full Text Available Introduction: Animations of biochemical processes and virtual laboratory environments lead to true molecular simulations. The use of interactive software’s in education can improve cognitive capacity, better learning and, mainly, it makes information acquisition easier. Material and Methods: This work presents the development of a biochemical hypermedia to understanding of the galactose metabolism. It was developed with the help of concept maps, ISIS Draw, ADOBE Photoshop and FLASH MX Program. Results and Discussion: A step by step animation process shows the enzymatic reactions of galactose conversion to glucose-1-phosphate (to glycogen synthesis, glucose-6-phosphate (glycolysis intermediary, UDP-galactose (substrate to mucopolysaccharides synthesis and collagen’s glycosylation. There are navigation guide that allow scrolling the mouse over the names of the components of enzymatic reactions of via the metabolism of galactose. Thus, explanatory text box, chemical structures and animation of the actions of enzymes appear to navigator. Upon completion of the module, the user’s response to the proposed exercise can be checked immediately through text box with interactive content of the answer. Conclusion: This hypermedia was presented for undergraduate students (UFSC who revealed that it was extremely effective in promoting the understanding of the theme.

  12. Considering on Construction of Information Platform of Military Logistics Integration%对军事物流一体化信息平台建设的思考

    Institute of Scientific and Technical Information of China (English)

    宫志萍; 刘金彪; 张智文

    2011-01-01

    研究了美军在军事物流信息化建设方面的基本做法:强化核心信息系统建设,实现军事物流可视化;坚持标准化和系列化;打造可视化后勤网络,实现军事物流运作信息的实时获取;开发联合决策支持工具。阐述了美军的做法时我军的启示,并就我军开展军事物流一体化信息平台建设的总体目标、总体要求、主要内容、技术实现思路和需要解决的关键技术问题等方面,提出了宏观思路和总体构想。%The basic approaches of US military logistics informationization construction were introduced, which were strengthening core information system construction and realizing military logistics visibility, standardization and serialization, building visible logistics network and real time acquiring of the information of military logistics operation, and developing joint decision support tools. The inspirations of the approaches US army were discussed. Macro ideas and overall visions of carrying out military logistics information platform construction were put forward, including overall goals, overall requirements, main content, technical implementation ideas, and the key technical problems needed to be solved.

  13. Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production.

    Science.gov (United States)

    Chen, Xianzhong; Zhou, Li; Tian, Kangming; Kumar, Ashwani; Singh, Suren; Prior, Bernard A; Wang, Zhengxiang

    2013-12-01

    In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based intensive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.

  14. Enterprise ERP System Platform Integration Framework With FDSS Research and Application%企业ERP与FDSS系统平台集成框架的研究及应用

    Institute of Scientific and Technical Information of China (English)

    何源

    2015-01-01

    EAI system integration technology is widely used and it wil be a trend in the future.However,the integration in the enterprise management and financial decisions stil belongs to the innovative research and development stage.Theses can integrate the required information and resources in the unified architecture of the platform andrealize the seamless connection between ERP and FDDS effectively using the EAI system integration technology.Meanwhile,using the EAI system integration technology can integrate the distributed system technology of large enterprises,provide data synchronization and resource sharing for the enterprise efficiency,security and steadiness,realize the application system integration of large enterprises and the data sharing complementary characteristics between enterprise resource planning management and financial decision support.By using this achievement,the enterprise performance management and business decisions wil step to a new level.%EAI系统集成技术应用广泛,也是未来发展的一种趋势,但在企业经营管理与财务决策方面的集成尚属创新研发阶段。论文通过EAI系统集成技术,将所需信息资源集成于统一的架构平台中,有效地实现了ERP与FDDS两大系统的无缝链接;把大型企业分散的系统技术整合协同起来,为企业高效、安全稳固地提供数据同步与资源共享,实现大型企业应用系统集成,较好地解决了企业资源计划管理与财务决策支持的数据分享与特性互补。该项成果地应用,必定能使企业的绩效管理与经营决策迈上新台阶。

  15. Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring.

    Science.gov (United States)

    Fattori, G; Saito, N; Seregni, M; Kaderka, R; Pella, A; Constantinescu, A; Riboldi, M; Steidl, P; Cerveri, P; Bert, C; Durante, M; Baroni, G

    2014-12-01

    The integrated use of optical technologies for patient monitoring is addressed in the framework of time-resolved treatment delivery for scanned ion beam therapy. A software application has been designed to provide the therapy control system (TCS) with a continuous geometrical feedback by processing the external surrogates tridimensional data, detected in real-time via optical tracking. Conventional procedures for phase-based respiratory phase detection were implemented, as well as the interface to patient specific correlation models, in order to estimate internal tumor motion from surface markers. In this paper, particular attention is dedicated to the quantification of time delays resulting from system integration and its compensation by means of polynomial interpolation in the time domain. Dedicated tests to assess the separate delay contributions due to optical signal processing, digital data transfer to the TCS and passive beam energy modulation actuation have been performed. We report the system technological commissioning activities reporting dose distribution errors in a phantom study, where the treatment of a lung lesion was simulated, with both lateral and range beam position compensation. The zero-delay systems integration with a specific active scanning delivery machine was achieved by tuning the amount of time prediction applied to lateral (14.61 ± 0.98 ms) and depth (34.1 ± 6.29 ms) beam position correction signals, featuring sub-millimeter accuracy in forward estimation. Direct optical target observation and motion phase (MPh) based tumor motion discretization strategies were tested, resulting in 20.3(2.3)% and 21.2(9.3)% median (IQR) percentual relative dose difference with respect to static irradiation, respectively. Results confirm the technical feasibility of the implemented strategy towards 4D treatment delivery, with negligible percentual dose deviations with respect to static irradiation.

  16. Research and Implementation of Sodium-Cooled Fast Reactor Engineering SOA Integration Platform Based Upon Information System%基于SOA的钠冷快堆工程信息系统集成平台的研究和实现

    Institute of Scientific and Technical Information of China (English)

    李健

    2014-01-01

    This paper analyzes the implementation of integrated technology and its limitations exist in the current construction of nuclear power construction management system, and for the sodium cooled fast reactor construction management features, proposed to build SOA-based cold sodium fast reactor engineering information system integration platform (hereinafter referred to as "integration Platform") design ideas. System integration platform for business functions, and system integration theory, the concepts of SOA, analysis and design in-depth study on the basis of the design of the overall structure of the sodium cooled fast reactor engineering information system integration platform, and discusses in detail the integrated platform-specific implementation process.%本文主要分析了当前核电建造施工管理系统集成的实现技术及其存在的局限性,并针对钠冷快堆的施工管理特点,提出了构建基于SOA的钠冷快堆工程信息系统集成平台(以下简称“集成平台”)的设计思想。对集成平台的业务功能体系、系统集成的理论、SOA的相关概念、分析与设计进行了深入研究,在此基础上设计了钠冷快堆工程信息系统集成平台的总体架构,并详细论述了集成平台的具体实现过程。

  17. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    After a long history dominated by out-migration, Denmark, Norway and Sweden have, in the past 50 years, become immigration societies. This article compares how these Scandinavian welfare societies have sought to incorporate immigrants and refugees into their national communities. It suggests that......, while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  18. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...... evolution does not make the platforms irrelevant. This research is based on case studies and applications in the two Danish companies, LEGO and Grundfos, where several platform development projects have been followed. LEGO is exceptional for their long experience with platform development and maintenance...

  19. Integrated microdroplet-based system for enzyme synthesis and sampling

    Science.gov (United States)

    Lapierre, Florian; Best, Michel; Stewart, Robert; Oakeshott, John; Peat, Thomas; Zhu, Yonggang

    2013-12-01

    Microdroplet-based microfluidic devices are emerging as powerful tools for a wide range of biochemical screenings and analyses. Monodispersed aqueous microdroplets from picoliters to nanoliters in volume are generated inside microfluidic channels within an immiscible oil phase. This results in the formation of emulsions which can contain various reagents for chemical reactions and can be considered as discrete bioreactors. In this paper an integrated microfluidic platform for the synthesis, screening and sorting of libraries of an organophosphate degrading enzyme is presented. The variants of the selected enzyme are synthesized from a DNA source using in-vitro transcription and translation method. The synthesis occurs inside water-in-oil emulsion droplets, acting as bioreactors. Through a fluorescence based detection system, only the most efficient enzymes are selected. All the necessary steps from the enzyme synthesis to selection of the best genes (producing the highest enzyme activity) are thus integrated inside a single and unique device. In the second part of the paper, an innovative design of the microfluidic platform is presented, integrating an electronic prototyping board for ensuring the communication between the various components of the platform (camera, syringe pumps and high voltage power supply), resulting in a future handheld, user-friendly, fully automated device for enzyme synthesis, screening and selection. An overview on the capabilities as well as future perspectives of this new microfluidic platform is provided.

  20. Efficient extraction of zero-phonon-line photons from single nitrogen-vacancy centers in an integrated GaP-on-diamond platform

    CERN Document Server

    Gould, Michael; Dadgostar, Shabnam; Hatami, Fariba; Fu, Kai-Mei C

    2016-01-01

    Scaling beyond two-node quantum networks using nitrogen vacancy (NV) centers in diamond is limited by the low probability of collecting zero phonon line (ZPL) photons from single centers. Here, we demonstrate GaP-on-diamond disk resonators which resonantly couple ZPL photons from single NV centers to single-mode waveguides. In these devices, the probability of a single NV center emitting a ZPL photon into the guided waveguide mode after optical excitation can reach 9%, due to a combination of resonant enhancement of the ZPL emission and efficient coupling between the resonator and waveguide. We verify the single-photon nature of the emission and experimentally demonstrate both high in-waveguide photon numbers and substantial Purcell enhancement for a set of devices. These devices may enable scalable integrated quantum networks based on NV centers.