WorldWideScience

Sample records for biochemical platform integration

  1. National Bioenergy Center, Biochemical Platform Integration Project: Quarterly Update, Summer 2011 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2011-09-01

    Summer 2011 issue of the National Bioenergy Center Biochemical Platform Integration Project quarterly update. Issue topics: evaluating new analytical techniques for measuring soluble sugars in the liquid portion of biomass hydrolysates, and measurement of the fraction of insoluble solids in biomass slurries.

  2. National Bioenergy Center - Biochemical Platform Integration Project: Quarterly Update, Winter 2010

    Energy Technology Data Exchange (ETDEWEB)

    Schell, D.

    2011-02-01

    Winter 2011 edition of the National Bioenergy Center's Biochemical Platform Integration Project quarterly newsletter. Issue topics: 33rd Symposium on Biotechnology for Fuels and Chemicals program topic areas; results from reactive membrane extraction of inhibitors from dilute-acid pretreated corn stover; list of 2010 task publications.

  3. Optical Biochemical Platforms for Nanoparticles Detection

    CERN Document Server

    Campanella, Clarissa Martina

    2014-01-01

    In the biochemical sensing field, a fervent research activity related to the development of real time, low cost, compact and high throughput devices for the detection and characterization of natural or synthetic nanoparticles NPs actually exists. In this research scenario, different platforms for biosensing purposes have been developed according to the huge amount of physical effects involved in the transduction of the biochemical-signal into a measurable output signal. In the present work two different optical platforms for NP detection have been investigated, one based on integrated optics and the other based on microscopy. Both the approaches rely on the study of the interaction of an electromagnetic wave with a small particle in the hypothesis of dealing with a Rayleigh scatterer, i.e. a nanoparticle having a size really smaller than the one of the wavelength of the incident light and scattering light elastically.

  4. 2009 Biochemical Conversion Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program’s Biochemical Conversion platform review meeting, held on April 14-16, 2009, at the Sheraton Denver Downtown, Denver, Colorado.

  5. 2011 Biomass Program Platform Peer Review: Biochemical Conversion

    Energy Technology Data Exchange (ETDEWEB)

    Pezzullo, Leslie [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Biochemical Conversion Platform Review meeting.

  6. Integrated chemical/biochemical sample collection, pre-concentration, and analysis on a digital microfluidic lab-on-a-chip platform

    Science.gov (United States)

    Fair, Richard B.; Khlystov, A.; Srinivasan, Vijay; Pamula, Vamsee K.; Weaver, Kathryn N.

    2004-12-01

    An ideal on-site chemical/biochemical analysis system must be inexpensive, sensitive, fully automated and integrated, reliable, and compatible with a broad range of samples. The advent of digital microfluidic lab-on-a-chip (LoC) technology offers such a detection system due to the advantages in portability, reduction of the volumes of the sample and reagents, faster analysis times, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. We describe progress towards integrating sample collection onto a digital microfluidic LoC that is a component of a cascade impactor device. The sample collection is performed by impacting airborne particles directly onto the surface of the chip. After the collection phase, the surface of the chip is washed with a micro-droplet of solvent. The droplet will be digitally directed across the impaction surface, dissolving sample constituents. Because of the very small droplet volume used for extraction of the sample from a wide colection area, the resulting solution is realatively concentrated and the analytes can be detected after a very short sampling time (1 min) due to such pre-concentration. After the washing phase, the droplet is mixed with specific reagents that produce colored reaction products. The concentration of the analyte is quantitatively determined by measuring absorption at target wavelengths using a simple light emitting diode and photodiode setup. Specific applications include automatic measurements of major inorganic ions in aerosols, such as sulfate, nitrate and ammonium, with a time resolution of 1 min and a detection limit of 30 nm/m3. We have already demonstrated the detection and quantification of nitroaromatic explosives without integrating the sample collection. Other applications being developed include airborne bioagent detection.

  7. Quantum photonics hybrid integration platform

    OpenAIRE

    Murray, E.; Ellis, D. J. P.; Meany, T.; Floether, F.F.; Lee, J P; Griffiths, J. P.; Jones, G.A.C.; Farrer, I.; Ritchie, D. A.; Bennett, A J; Shields, A.J.

    2015-01-01

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO2 cladding. A tuneable Mach Zehnder interferometer (MZI) modulat...

  8. CORBA Based Information Integration Platform for CIMS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new information integration platform for computer integrated manufacturing system(CIMS) is presented, which is based on agent and CORBA. CORBA enhances the system integration be-cause it is an industry-standard for interoperable, distributed objects across heterogeneous hardware andsoftware platform. Agent technology is used to improve intelligence of integration system. In order to im-plement the information integration platform, we use network integration server to integrate network, de-sign a generic database agent to integrate database, adopt multi-agent based architecture to integrate appli-cation, and utilize wrapper as CORBA object to integrate legacy code.

  9. Quantum photonics hybrid integration platform

    International Nuclear Information System (INIS)

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO2 cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement

  10. Quantum photonics hybrid integration platform

    Energy Technology Data Exchange (ETDEWEB)

    Murray, E.; Floether, F. F. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Ellis, D. J. P.; Meany, T.; Bennett, A. J., E-mail: anthony.bennet@crl.toshiba.co.uk; Shields, A. J. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Lee, J. P. [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge CB4 0GZ (United Kingdom); Engineering Department, University of Cambridge, 9 J. J. Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A. [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2015-10-26

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO{sub 2} cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  11. Integrating data from heterogeneous DNA microarray platforms

    OpenAIRE

    Valente, Eduardo; Rocha, Miguel

    2015-01-01

    DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data dimensionality problem. The integration of heterogeneous DNA microarray platforms comprehends a set...

  12. Hybrid Photonic Integration on a Polymer Platform

    OpenAIRE

    Ziyang Zhang; David Felipe; Vasilis Katopodis; Panos Groumas; Christos Kouloumentas; Hercules Avramopoulos; Jean-Yves Dupuy; Agnieszka Konczykowska; Alberto Dede; Antonio Beretta; Antonello Vannucci; Giulio Cangini; Raluca Dinu; Detlef Schmidt; Martin Moehrle

    2015-01-01

    To fulfill the functionality demands from the fast developing optical networks, a hybrid integration approach allows for combining the advantages of various material platforms. We have established a polymer-based hybrid integration platform (polyboard), which provides flexible optical input/ouptut interfaces (I/Os) that allow robust coupling of indium phosphide (InP)-based active components, passive insertion of thin-film-based optical elements, and on-chip attachment of optical fibers. This ...

  13. VA's Integrated Imaging System on three platforms.

    Science.gov (United States)

    Dayhoff, R E; Maloney, D L; Majurski, W J

    1992-01-01

    The DHCP Integrated Imaging System provides users with integrated patient data including text, image and graphics data. This system has been transferred from its original two screen DOS-based MUMPS platform to an X window workstation and a Microsoft Windows-based workstation. There are differences between these various platforms that impact on software design and on software development strategy. Data structures and conventions were used to isolate hardware, operating system, imaging software, and user-interface differences between platforms in the implementation of functionality for text and image display and interaction. The use of an object-oriented approach greatly increased system portability. PMID:1482983

  14. Architectural view model for an integration platform

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2012-03-01

    Full Text Available The most common architectural view model is "4+1" by Philipe Kruchten. This model presents the views required for a full description of computer system architecture. By contrast, this model seems to be insufficient to describe architecture of integration platform. Definitely lacks the view of integrated business processes. In the serviceoriented approach, one of the basic elements is a contract. It should also be included in the description of the architecture. Moreover, very important are integration mechanisms and mediation flows that should be presented in the description of architecture. Hence the need for integrated services view, and manner of their integration on the enterprise service bus. Use case view should also be extended by stereotypes required for presenting functionality exposed for other computer systems. It is therefore proposed architectural view model “1+5” for an integration platform. This model has following architectural views: Integrated processes, Use Cases, Logical, Integrated Services, Contracts, Deployment. Furthermore, in article was presented new UML profile "UML Profile for Integration Flows". In the profile were placed stereotypes corresponding to integration patterns and mediation mechanisms. It is important, that UML activity diagram was extended and its special form was obtained to model mediation flows on integration platform. Thus was proposed a new UML diagram: mediation flows diagram.

  15. Cross-platform continuous integration

    OpenAIRE

    Ferjančič, Klemen

    2016-01-01

    This thesis describes planning and implementation of a system, which allows us to perform continuous integration of source code on several operating systems at once, with compiled languages such as C or C++ in mind. The main goals of the system are a publicly available service for developers, scalability as the quantity of added projects grows and isolation of the projects to avoid build and test conflicts. Scalability is achieved with cloud integration, which allows us to buy new servers ...

  16. Emerging heterogeneous integrated photonic platforms on silicon

    Science.gov (United States)

    Fathpour, Sasan

    2015-05-01

    Silicon photonics has been established as a mature and promising technology for optoelectronic integrated circuits, mostly based on the silicon-on-insulator (SOI) waveguide platform. However, not all optical functionalities can be satisfactorily achieved merely based on silicon, in general, and on the SOI platform, in particular. Long-known shortcomings of silicon-based integrated photonics are optical absorption (in the telecommunication wavelengths) and feasibility of electrically-injected lasers (at least at room temperature). More recently, high two-photon and free-carrier absorptions required at high optical intensities for third-order optical nonlinear effects, inherent lack of second-order optical nonlinearity, low extinction ratio of modulators based on the free-carrier plasma effect, and the loss of the buried oxide layer of the SOI waveguides at mid-infrared wavelengths have been recognized as other shortcomings. Accordingly, several novel waveguide platforms have been developing to address these shortcomings of the SOI platform. Most of these emerging platforms are based on heterogeneous integration of other material systems on silicon substrates, and in some cases silicon is integrated on other substrates. Germanium and its binary alloys with silicon, III-V compound semiconductors, silicon nitride, tantalum pentoxide and other high-index dielectric or glass materials, as well as lithium niobate are some of the materials heterogeneously integrated on silicon substrates. The materials are typically integrated by a variety of epitaxial growth, bonding, ion implantation and slicing, etch back, spin-on-glass or other techniques. These wide range of efforts are reviewed here holistically to stress that there is no pure silicon or even group IV photonics per se. Rather, the future of the field of integrated photonics appears to be one of heterogenization, where a variety of different materials and waveguide platforms will be used for different purposes with

  17. Emerging heterogeneous integrated photonic platforms on silicon

    Directory of Open Access Journals (Sweden)

    Fathpour Sasan

    2015-05-01

    Full Text Available Silicon photonics has been established as a mature and promising technology for optoelectronic integrated circuits, mostly based on the silicon-on-insulator (SOI waveguide platform. However, not all optical functionalities can be satisfactorily achieved merely based on silicon, in general, and on the SOI platform, in particular. Long-known shortcomings of silicon-based integrated photonics are optical absorption (in the telecommunication wavelengths and feasibility of electrically-injected lasers (at least at room temperature. More recently, high two-photon and free-carrier absorptions required at high optical intensities for third-order optical nonlinear effects, inherent lack of second-order optical nonlinearity, low extinction ratio of modulators based on the free-carrier plasma effect, and the loss of the buried oxide layer of the SOI waveguides at mid-infrared wavelengths have been recognized as other shortcomings. Accordingly, several novel waveguide platforms have been developing to address these shortcomings of the SOI platform. Most of these emerging platforms are based on heterogeneous integration of other material systems on silicon substrates, and in some cases silicon is integrated on other substrates. Germanium and its binary alloys with silicon, III–V compound semiconductors, silicon nitride, tantalum pentoxide and other high-index dielectric or glass materials, as well as lithium niobate are some of the materials heterogeneously integrated on silicon substrates. The materials are typically integrated by a variety of epitaxial growth, bonding, ion implantation and slicing, etch back, spin-on-glass or other techniques. These wide range of efforts are reviewed here holistically to stress that there is no pure silicon or even group IV photonics per se. Rather, the future of the field of integrated photonics appears to be one of heterogenization, where a variety of different materials and waveguide platforms will be used for

  18. Hybrid integrated platforms for silicon photonics

    OpenAIRE

    Bowers, John E; Roel Baets; Gunther Roelkens; Di Liang

    2010-01-01

    A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon phot...

  19. 2009 Integrated Biorefinery Platform Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2009-12-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the U.S. Department of Energy Biomass Program‘s Integrated Biorefinery (IBR) platform review meeting, held on February 18–19, 2009, at the Westin National Harbor, National Harbor, Maryland.

  20. Integrating data from heterogeneous DNA microarray platforms.

    Science.gov (United States)

    Valente, Eduardo; Rocha, Miguel

    2015-01-01

    DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data dimensionality problem. The integration of heterogeneous DNA microarray platforms comprehends a set of tasks that range from the re-annotation of the features used on gene expression, to data normalization and batch effect elimination. In this work, a complete methodology for gene expression data integration and application is proposed, which comprehends a transcript-based re-annotation process and several methods for batch effect attenuation. The integrated data will be used to select the best feature set and learning algorithm for a brain tumor classification case study. The integration will consider data from heterogeneous Agilent and Affymetrix platforms, collected from public gene expression databases, such as The Cancer Genome Atlas and Gene Expression Omnibus. PMID:26673932

  1. Integrated Spintronic Platforms for Biomolecular Recognition Detection

    Science.gov (United States)

    Martins, V. C.; Cardoso, F. A.; Loureiro, J.; Mercier, M.; Germano, J.; Cardoso, S.; Ferreira, R.; Fonseca, L. P.; Sousa, L.; Piedade, M. S.; Freitas, P. P.

    2008-06-01

    This paper covers recent developments in magnetoresistive based biochip platforms fabricated at INESC-MN, and their application to the detection and quantification of pathogenic waterborn microorganisms in water samples for human consumption. Such platforms are intended to give response to the increasing concern related to microbial contaminated water sources. The presented results concern the development of biological active DNA chips and protein chips and the demonstration of the detection capability of the present platforms. Two platforms are described, one including spintronic sensors only (spin-valve based or magnetic tunnel junction based), and the other, a fully scalable platform where each probe site consists of a MTJ in series with a thin film diode (TFD). Two microfluidic systems are described, for cell separation and concentration, and finally, the read out and control integrated electronics are described, allowing the realization of bioassays with a portable point of care unit. The present platforms already allow the detection of complementary biomolecular target recognition with 1 pM concentration.

  2. Snap: An Integrated SNP Annotation Platform

    DEFF Research Database (Denmark)

    Li, S.; Ma, L.; Li, H.;

    2007-01-01

    Snap (Single Nucleotide Polymorphism Annotation Platform) is a server designed to comprehensively analyze single genes and relationships between genes basing on SNPs in the human genome. The aim of the platform is to facilitate the study of SNP finding and analysis within the framework of medical...... research. Using a user-friendly web interface, genes can be searched by name, description, position, SNP ID or clone name. Several public databases are integrated, including gene information from Ensembl, protein features from Uniprot/SWISS-PROT, Pfam and DAS-CBS. Gene relationships are fetched from BIND...

  3. Hybrid Integrated Platforms for Silicon Photonics

    Directory of Open Access Journals (Sweden)

    John E. Bowers

    2010-03-01

    Full Text Available A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

  4. Communication System for CIMS Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    CIMS has seen the growth of multiple incompatible hardware architectur es, each architecture supporting several incompatible operating systems, and eac h platform operating with various incompatible development tools (e.g., programm ing language compilers, DBMS, etc.) and one or more incompatible graphic user in terfaces. Also, the growth of the Internet, the World-Wide Web, has introduced new dimensio ns of complexity into the development process. All of these must be dealt with a s the application is made workable in a distributed client-server environment. This paper outlines the architecture of a communication system for the CIMS appl ication integration platform. The communication system makes possible the reque st for service across heterogeneous platforms and networks, and provides some co mmon solutions to issues common to CIMS applications.

  5. Hybrid Photonic Integration on a Polymer Platform

    Directory of Open Access Journals (Sweden)

    Ziyang Zhang

    2015-09-01

    Full Text Available To fulfill the functionality demands from the fast developing optical networks, a hybrid integration approach allows for combining the advantages of various material platforms. We have established a polymer-based hybrid integration platform (polyboard, which provides flexible optical input/ouptut interfaces (I/Os that allow robust coupling of indium phosphide (InP-based active components, passive insertion of thin-film-based optical elements, and on-chip attachment of optical fibers. This work reviews the recent progress of our polyboard platform. On the fundamental level, multi-core waveguides and polymer/silicon nitride heterogeneous waveguides have been fabricated, broadening device design possibilities and enabling 3D photonic integration. Furthermore, 40-channel optical line terminals and compact, bi-directional optical network units have been developed as highly functional, low-cost devices for the wavelength division multiplexed passive optical network. On a larger scale, thermo-optic elements, thin-film elements and an InP gain chip have been integrated on the polyboard to realize a colorless, dual-polarization optical 90° hybrid as the frontend of a coherent receiver. For high-end applications, a wavelength tunable 100Gbaud transmitter module has been demonstrated, manifesting the joint contribution from the polyboard technology, high speed polymer electro-optic modulator, InP driver electronics and ceramic electronic interconnects.

  6. Biomass Program 2007 Program Peer Review - Biochemical and Products Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Biochemical and Products Platform Review held on August 7-9, 2007 in Denver, Colorado.

  7. Biochemical composition of zooplankton of Bombay High (oil platform) area in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Bhat, K.L.; Wagh, A.B.

    Variations in the biochemical constituents and calorific values of zooplankton from an off-shore oil processing platform were estimated. Mean value of biomass was 0.35 ml.m/3 with relatively higher values during post-monsoon period. Copepods formed...

  8. Fully integrated biochip platforms for advanced healthcare.

    Science.gov (United States)

    Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

    2012-01-01

    Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications. PMID:23112644

  9. Fully Integrated Biochip Platforms for Advanced Healthcare

    Science.gov (United States)

    Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

    2012-01-01

    Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications. PMID:23112644

  10. Integrated platform and API for electrophysiological data.

    Science.gov (United States)

    Sobolev, Andrey; Stoewer, Adrian; Leonhardt, Aljoscha; Rautenberg, Philipp L; Kellner, Christian J; Garbers, Christian; Wachtler, Thomas

    2014-01-01

    Recent advancements in technology and methodology have led to growing amounts of increasingly complex neuroscience data recorded from various species, modalities, and levels of study. The rapid data growth has made efficient data access and flexible, machine-readable data annotation a crucial requisite for neuroscientists. Clear and consistent annotation and organization of data is not only an important ingredient for reproducibility of results and re-use of data, but also essential for collaborative research and data sharing. In particular, efficient data management and interoperability requires a unified approach that integrates data and metadata and provides a common way of accessing this information. In this paper we describe GNData, a data management platform for neurophysiological data. GNData provides a storage system based on a data representation that is suitable to organize data and metadata from any electrophysiological experiment, with a functionality exposed via a common application programming interface (API). Data representation and API structure are compatible with existing approaches for data and metadata representation in neurophysiology. The API implementation is based on the Representational State Transfer (REST) pattern, which enables data access integration in software applications and facilitates the development of tools that communicate with the service. Client libraries that interact with the API provide direct data access from computing environments like Matlab or Python, enabling integration of data management into the scientist's experimental or analysis routines. PMID:24795616

  11. Integrating Carbon Nanotubes into Microfluidic Chip for Separating Biochemical Compounds

    DEFF Research Database (Denmark)

    Chen, Miaoxiang Max; Mogensen, Klaus Bo; Bøggild, Peter;

    2012-01-01

    We present a new type of device to separate biochemical compounds wherein carbon nanotubes (CNTs) are integrated as chromatographic stationary phase. The CNTs were directly grown on the bottom of microfluidic channels on Si/SiO2 substrates by chemical vapor deposition (CVD). Acetylene was used as...

  12. Integrated Microreactor for Chemical and Biochemical Applications

    Science.gov (United States)

    Schwesinger, N.; Dressler, L.; Frank, Th.; Wurmus, H.

    1995-01-01

    A completely integrated microreactor was developed that allows for the processing of very small amounts of chemical solutions. The entire system comprises several pumps and valves arranged in different branches as well as a mixing unit and a reaction chamber. The streaming path of each branch contains two valves and one pump each. The pumps are driven by piezoelectric elements mounted on thin glass membranes. Each pump is about 3.5 mm x 3.5 mm x 0.7 mm. A pumping rate up to 25 microliters per hour can be achieved. The operational voltage ranges between 40 and 200 V. A volume stroke up to 1.5 millimeter is achievable from the membrane structures. The valves are designed as passive valves. Sealing is by thin metal films. The dimension of a valve unit is 0.8 x 0.8. 07 mm. The ends of the separate streaming branches are arranged to meet in one point. This point acts as the beginning of a mixer unit which contains several fork-shaped channels. The arrangement of these channels allows for the division of the whole liquid stream into partial streams and their reuniting. A homogeneous mixing of solutions and/or gases can be observed after having passed about 10 of the fork elements. A reaction chamber is arranged behind the mixing unit to support the chemical reaction of special fluids. This unit contains heating elements placed outside of the chamber. The complete system is arranged in a modular structure and is built up of silicon. It comprises three silicon wafers bonded together by applying the silicon direct bonding technology. The silicon structures are made only by wet chemical etching processes. The fluid connections to the outside are realized using standard injection needles glued into v-shaped structures on the silicon wafers. It is possible to integrate other components, like sensors or electronic circuits using silicon as the basic material.

  13. Integrated chemiresistor array for small sensor platforms

    Energy Technology Data Exchange (ETDEWEB)

    HUGHES,ROBERT C.; CASALNUOVO,STEPHEN A.; WESSENDORF,KURT O.; SAVIGNON,DANIEL J.; HIETALA,SUSAN LESLIE; PATEL,SANJAY V.

    2000-04-13

    Chemiresistors are fabricated from materials that change their electrical resistance when exposed to certain chemical species. Composites of soluble polymers with metallic particles have shown remarkable sensitivity to many volatile organic chemicals, depending on the ability of the analyte molecules to swell the polymer matrix. These sensors can be made extremely small (< 100 square microns), operate at ambient temperatures, and require almost no power to read-out. However, the chemiresistor itself is only a part of a more complex sensor system that delivers chemical information to a user who can act on the information. The authors present the design, fabrication and performance of a chemiresistor array chip with four different chemiresistor materials, heaters and a temperature sensor. They also show the design and fabrication of an integrated chemiresistor array, where the electronics to read-out the chemiresistors is on the same chip with the electrodes for the chemiresistors. The circuit was designed to perform several functions to make the sensor data more useful. This low-power, integrated chemiresistor array is small enough to be deployed on a Sandia-developed microrobot platform.

  14. Structural Integrity Analysis of CEA Change Platform

    International Nuclear Information System (INIS)

    The Control Element Assembly Change Platform (CEA CP) is similar to a gantry crane. The CEA CP for Shin-Kori units 3 and 4 (SKN 3 and 4) consists of a bridge, which spans the reactor cavity pool and a gantry superstructure mounted on the bridge. The structure is approximately 8.8 m wide, 4.9 m long and 10.6 m high. The gantry superstructure supports one ton capacity hoist trolley and the bridge supports the In Core Instrumentation (ICI) retrieval cart which moves along the bridge. This paper presents the dynamic and structural analysis of CEA CP which is greater than that of the previous nuclear power plants to verify the structural integrity under the application of the earthquake spectrum. The analysis have been performed using the three orthogonal SSE response spectrum for SKN 3 and 4 which shows much higher acceleration value than OPR- 1000 Plants. In addition, the analyses are performed by 3-dimensional finite element analysis using ANSYS software

  15. HAMMLAB 2000 integration platform - overall design

    International Nuclear Information System (INIS)

    This document contains the top-level requirements and design specification for the HAMMLAB 2000 Integration Platform (H2k IP). The system architecture for the IP is described, and the various modules are identified. The tasks of each module are described from an overall perspective, details are left for the various unit design documents. The document clearly identifies the boundary of the H2k IP, what modules are regarded to be part of the IP and what modules are regarded as external units. It is stressed that the IP will be a set of general modules that are reused for each simulator system implemented in HAMMLAB. External units must interface to the IP in order to retrieve simulator data or issue simulator actions. The document describes how the IP will arrange for external units to interface. A separate chapter discuss how the general IP modules will be configured in order to operate correctly and efficiently for a given simulator system. Finally the document presents an overview of the H2k IP development process until the implementation phase (author) (ml)

  16. Hybrid laser integration for silicon photonics platform

    Science.gov (United States)

    Yang, Shuyu

    Silicon photonics has attracted extensive attention in both academia and industry in recent years, as an enabling technology to address the exponentially increasing demands for communication bandwidth. It brings state-of-the-art complementary metal-oxide-semiconductor (CMOS) processing technology to the field of photonic integration. The high yield and uniformity of silicon devices make it possible to build complex photonic systems-on-chip in large production volumes. Cutting-edge device performance has been demonstrated on this platform, including high-speed modulators, photodetectors, and passive devices such as the Y-junction, waveguide crossing, and arrayed waveguide gratings. As the device library quickly matures, an integrated laser source for a transmitter remains missing from the design kit. I demonstrated hybrid external cavity lasers by integrating reflective optical semiconductor amplifiers and silicon photonics chips. The gain chip and silicon chip can be designed and optimized independently, which is a significant advantage compared to bonding an III-V film on top of the silicon chip. Advanced optoelectronics packaging processes can be leveraged for chip alignment. Tunable C-Band (near 1550 nm) lasers with 10 mW on-chip power and less than 220 kHz bandwidth are demonstrated. O-Band lasers (operating near 1310 nm) as well as successful data transmission at 10 Gb/s and 40 Gb/s using the hybrid laser as the light source are also demonstrated. I designed a single cavity, multi wavelength laser by utilizing a quantum dot SOA, Sagnac loop and micro-ring based silicon photonics half cavity. Four lasing peaks with less than 3 dB power non-uniformity were measured, as well as 4 x 10 Gb/s error free data transmission. In addition to my main focus on RSOA/Silicon external cavity lasers, I propose and demonstrate a novel germanium-assisted grating coupler with low loss on-and-off chip fiber coupling. A coupling efficiency of 76% at 1.55 microm and 40 nm 1 d

  17. A hybrid approach to device integration on a genetic analysis platform

    International Nuclear Information System (INIS)

    Point-of-care (POC) systems require significant component integration to implement biochemical protocols associated with molecular diagnostic assays. Hybrid platforms where discrete components are combined in a single platform are a suitable approach to integration, where combining multiple device fabrication steps on a single substrate is not possible due to incompatible or costly fabrication steps. We integrate three devices each with a specific system functionality: (i) a silicon electro-wetting-on-dielectric (EWOD) device to move and mix sample and reagent droplets in an oil phase, (ii) a polymer microfluidic chip containing channels and reservoirs and (iii) an aqueous phase glass microarray for fluorescence microarray hybridization detection. The EWOD device offers the possibility of fully integrating on-chip sample preparation using nanolitre sample and reagent volumes. A key challenge is sample transfer from the oil phase EWOD device to the aqueous phase microarray for hybridization detection. The EWOD device, waveguide performance and functionality are maintained during the integration process. An on-chip biochemical protocol for arrayed primer extension (APEX) was implemented for single nucleotide polymorphism (SNiP) analysis. The prepared sample is aspirated from the EWOD oil phase to the aqueous phase microarray for hybridization. A bench-top instrumentation system was also developed around the integrated platform to drive the EWOD electrodes, implement APEX sample heating and image the microarray after hybridization. (paper)

  18. Integrating Carbon Nanotubes into Microfluidic Chip for Separating Biochemical Compounds

    OpenAIRE

    Chen, Miaoxiang Max; Mogensen, Klaus Bo; BØGGILD, Peter; Kutter, Jörg Peter

    2012-01-01

    We present a new type of device to separate biochemical compounds wherein carbon nanotubes (CNTs) are integrated as chromatographic stationary phase. The CNTs were directly grown on the bottom of microfluidic channels on Si/SiO2 substrates by chemical vapor deposition (CVD). Acetylene was used as carbon source and Ni was employed as catalyst. For electrokinetic separations, higher electrical field strength is usually required; therefore, the CNTs were constructed in pillar-array-form by patte...

  19. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications.

    Science.gov (United States)

    Cennamo, Nunzio; Chiavaioli, Francesco; Trono, Cosimo; Tombelli, Sara; Giannetti, Ambra; Baldini, Francesco; Zeni, Luigi

    2016-01-01

    An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay. PMID:26861328

  20. KinomeXplorer: an integrated platform for kinome biology studies

    DEFF Research Database (Denmark)

    Horn, Heiko; Schoof, Erwin; Kim, Jinho; Robin, Xavier; Miller, Martin Lee; Diella, Francesca; Palma, Anita; Cesareni, Gianni; Jensen, Lars Juhl; Linding, Rune

    2014-01-01

    A letter to the editor is presented related to the KinomeXplorer, an integrated platform providing workflows to efficiently analyze phosphorylation dependent interaction networks or kinase signaling networks....

  1. Microfluidic Technology Platforms for Synthesizing, Labeling and Measuring the Kinetics of Transport and Biochemical Reactions for Developing Molecular Imaging Probes

    Energy Technology Data Exchange (ETDEWEB)

    Phelps, Michael E.

    2009-09-01

    Radiotracer techniques are used in environmental sciences, geology, biology and medicine. Radiotracers with Positron Emission Tomography (PET) provided biological examinations of ~3 million patients 2008. Despite the success of positron labeled tracers in many sciences, there is limited access in an affordable and convenient manner to develop and use new tracers. Integrated microfluidic chips are a new technology well matched to the concentrations of tracers. Our goal is to develop microfluidic chips and new synthesis approaches to enable wide dissemination of diverse types of tracers at low cost, and to produce new generations of radiochemists for which there are many unfilled jobs. The program objectives are to: 1. Develop an integrated microfluidic platform technology for synthesizing and 18F-labeling diverse arrays of different classes of molecules. 2. Incorporate microfluidic chips into small PC controlled devices (“Synthesizer”) with a platform interfaced to PC for electronic and fluid input/out control. 3. Establish a de-centralized model with Synthesizers for discovering and producing molecular imaging probes, only requiring delivery of inexpensive [18F]fluoride ion from commercial PET radiopharmacies vs the centralized approach of cyclotron facilities synthesizing and shipping a few different types of 18F-probes. 4. Develop a position sensitive avalanche photo diode (PSAPD) camera for beta particles embedded in a microfluidic chip for imaging and measuring transport and biochemical reaction rates to valid new 18F-labeled probes in an array of cell cultures. These objectives are met within a research and educational program integrating radio-chemistry, synthetic chemistry, biochemistry, engineering and biology in the Crump Institute for Molecular Imaging. The Radiochemistry Training Program exposes PhD and post doctoral students to molecular imaging in vitro in cells and microorganisms in microfluidic chips and in vivo with PET, from new technologies

  2. From the Sugar Platform to biofuels and biochemicals : Final report for the European Commission Directorate-General Energy

    OpenAIRE

    Taylor, R.; Nattrass, L.; Alberts, G.; Robson, P; Chudziak, C.; Bauen, A.; Libelli, I.M.; Lotti, G; Prussi, M.; Nistri, R; Chiaramonti, D.; López-Contreras, A.M.; Bos, H.H.; Eggink, G; Springer, J

    2015-01-01

    Numerous potential pathways to biofuels and biochemicals exist via the sugar platform1. This study uses literature surveys, market data and stakeholder input to provide a comprehensive evidence base for policymakers and industry – identifying the key benefits and development needs for the sugar platform. The study created a company database for 94 sugar-based products, with some already commercial, the majority at research/pilot stage, and only a few demonstration plants crossing the “valley ...

  3. Development of integrated platform for computational material design

    Energy Technology Data Exchange (ETDEWEB)

    Kiyoshi, Matsubara; Kumi, Itai; Nobutaka, Nishikawa; Akifumi, Kato [Center for Computational Science and Engineering, Fuji Research Institute Corporation (Japan); Hideaki, Koike [Advance Soft Corporation (Japan)

    2003-07-01

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned.

  4. Development of integrated platform for computational material design

    International Nuclear Information System (INIS)

    The goal of our project is to design and develop a problem-solving environment (PSE) that will help computational scientists and engineers develop large complicated application software and simulate complex phenomena by using networking and parallel computing. The integrated platform, which is designed for PSE in the Japanese national project of Frontier Simulation Software for Industrial Science, is defined by supporting the entire range of problem solving activity from program formulation and data setup to numerical simulation, data management, and visualization. A special feature of our integrated platform is based on a new architecture called TASK FLOW. It integrates the computational resources such as hardware and software on the network and supports complex and large-scale simulation. This concept is applied to computational material design and the project 'comprehensive research for modeling, analysis, control, and design of large-scale complex system considering properties of human being'. Moreover this system will provide the best solution for developing large and complicated software and simulating complex and large-scaled phenomena in computational science and engineering. A prototype has already been developed and the validation and verification of an integrated platform will be scheduled by using the prototype in 2003. In the validation and verification, fluid-structure coupling analysis system for designing an industrial machine will be developed on the integrated platform. As other examples of validation and verification, integrated platform for quantum chemistry and bio-mechanical system are planned

  5. Synthesis and design of optimal biorefinery using an expanded network with thermochemical and biochemical biomass conversion platforms

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    2013-01-01

    This study presents the development of an expanded biorefinery processing network for producing biofuels that combines biochemical and thermochemical conversion platforms. The expanded network is coupled to a framework that uses a superstructure based optimization approach to generate and compare...... for identifying at early stage optimal biorefinery concept with respect to technical, economic and environmental criteria....

  6. From the Sugar Platform to biofuels and biochemicals : Final report for the European Commission Directorate-General Energy

    NARCIS (Netherlands)

    Taylor, R.; Nattrass, L.; Alberts, G.; Robson, P.; Chudziak, C.; Bauen, A.; Libelli, I.M.; Lotti, G.; Prussi, M.; Nistri, R.; Chiaramonti, D.; lópez-Contreras, A.M.; Bos, H.H.; Eggink, G.; Springer, J.; Bakker, R.; Ree, van R.

    2015-01-01

    Numerous potential pathways to biofuels and biochemicals exist via the sugar platform1. This study uses literature surveys, market data and stakeholder input to provide a comprehensive evidence base for policymakers and industry – identifying the key benefits and development needs for the sugar plat

  7. Current State and Development Trends for Integration Platforms

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The integration platform (IP) is an advanced support tool for application softwa re development and integration. This paper analyzes the shortcomings of traditio nal software programming methods, introduces the background and development of i ntegration platforms and presents the basic functions and system architecture of computer integrated manufacture computing environment (CCE) IP as well as the i ntegration framework. Computer integrated manufacturing system (CIMS) applicatio n IP is defined i n relation to the IP requirements for CIMS implementation within a company. The CIMS application IP is not only a support tool for application software developm ent, but also a support tool for software integration and system operation. Ther efore, the behavior and functions of a CIMS application IP must also include sof tware integration and system operation. The development trend for CIMS applicati on IPs is discussed in view of software technology development trends.

  8. ENTERPRISE INTEGRATION PLATFORM BASED ON SERVICE- ORIENTED ARCHITECTURE

    Institute of Scientific and Technical Information of China (English)

    MENG Xiaojun; ZHANG Xu; NING Ruxin; SONG Yu

    2008-01-01

    To achieve information integration, process integration and application integration of enterprise, an enterprise integration platform (EIP) based on service-oriented architecture (SOA) is built. The enterprise integration model depending on encapsulating the business processes as well as the enterprise applications by the neutral and standard web services is presented. The problem how to discover the existed enterprise resources and share them was resolved depending on the mechanism of publishing and discovering the services. The EIP is integrated closely with product lifecycle management (PLM) system so that the process integration as well as orchestration of the business process services is implemented by encapsulating the workflow engine of PLM system. Not only process integration and application integration, but also information integration based on the bill of material (BOM) conversion driven by process are achieved. Finally, an interpretive, qualitative case study on EIP is conducted for this research.

  9. Booly: a new data integration platform

    Directory of Open Access Journals (Sweden)

    Karten Harvey J

    2010-10-01

    Full Text Available Abstract Background Data integration is an escalating problem in bioinformatics. We have developed a web tool and warehousing system, Booly, that features a simple yet flexible data model coupled with the ability to perform powerful comparative analysis, including the use of Boolean logic to merge datasets together, and an integrated aliasing system to decipher differing names of the same gene or protein. Furthermore, Booly features a collaborative sharing system and a public repository so that users can retrieve new datasets while contributors can easily disseminate new content. Results We illustrate the uses of Booly with several examples including: the versatile creation of homebrew datasets, the integration of heterogeneous data to identify genes useful for comparing avian and mammalian brain architecture, and generation of a list of Food and Drug Administration (FDA approved drugs with possible alternative disease targets. Conclusions The Booly paradigm for data storage and analysis should facilitate integration between disparate biological and medical fields and result in novel discoveries that can then be validated experimentally. Booly can be accessed at http://booly.ucsd.edu.

  10. Platforms for integrated nonlinear optics compatible with silicon integrated circuits

    CERN Document Server

    Moss, David J

    2014-01-01

    Nonlinear photonic chips are capable of generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. We review recent progress in CMOS-compatible platforms for nonlinear optics, focusing on Hydex glass and silicon nitride and briefly discuss the promising new platform of amorphous silicon. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation, ultrafast optical pulse generation and measurement. We highlight their potential future impact as well as the challenges to achieving practical solutions for many key applications.

  11. INTEGRATING FACEBOOK AND ALUMNI INTO THE SOCIAL NETWORK MOBILE PLATFORM

    Directory of Open Access Journals (Sweden)

    Tzuo-Ming Chen

    2014-06-01

    Full Text Available Social network systems have become one of the most popular Internet applications in recent years. Mobile devices such as smartphones and tablets make Internet access easier than ever before. They have also brought new opportunities for the social platforms of universities and their alumni. This paper proposes a mobile platform integrating the public social network site, facebook (FB, and universities' alumni. Before the users in this platform can contact the alumni, they must know their latest status from FB. Users can also gain alumni’s personal information with their authorization from the universities’ database. In addition, the mobile platform utilizes the Google Sync feature, which provides users of the system with ubiquitous information retrieval in any location and from any device.

  12. Aneka Cloud Application Platform and Its Integration with Windows Azure

    CERN Document Server

    Wei, Yi; Vecchiola, Christian; Karunamoorthy, Dileban; Buyya, Rajkumar

    2011-01-01

    Aneka is an Application Platform-as-a-Service (Aneka PaaS) for Cloud Computing. It acts as a framework for building customized applications and deploying them on either public or private Clouds. One of the key features of Aneka is its support for provisioning resources on different public Cloud providers such as Amazon EC2, Windows Azure and GoGrid. In this chapter, we will present Aneka platform and its integration with one of the public Cloud infrastructures, Windows Azure, which enables the usage of Windows Azure Compute Service as a resource provider of Aneka PaaS. The integration of the two platforms will allow users to leverage the power of Windows Azure Platform for Aneka Cloud Computing, employing a large number of compute instances to run their applications in parallel. Furthermore, customers of the Windows Azure platform can benefit from the integration with Aneka PaaS by embracing the advanced features of Aneka in terms of multiple programming models, scheduling and management services, application...

  13. Fundamentals of power integrity for computer platforms and systems

    CERN Document Server

    DiBene, Joseph T

    2014-01-01

    An all-encompassing text that focuses on the fundamentals of power integrity Power integrity is the study of power distribution from the source to the load and the system level issues that can occur across it. For computer systems, these issues can range from inside the silicon to across the board and may egress into other parts of the platform, including thermal, EMI, and mechanical. With a focus on computer systems and silicon level power delivery, this book sheds light on the fundamentals of power integrity, utilizing the author's extensive background in the power integrity industry and un

  14. Practical assessment of Biba integrity for TCG-enabled platforms

    OpenAIRE

    Lioy, Antonio; Ramunno, Gianluca; Sassu, Roberto

    2014-01-01

    Checking the integrity of an application is necessary to determine if the latter will behave as expected. The method defined by the Trusted Computing Group consists in evaluating the fingerprints of the platform hardware and software components required for the proper functioning of the application to be assessed. However, this only ensures that a process was working correctly at load-time but not for its whole life-cycle. Policy-Reduced Integrity Measurement Architecture (PRIMA) addresses th...

  15. WiBasin: basin management through an integrated platform

    OpenAIRE

    Llort Pavon, Xavier; Sánchez-Diezma Guijarro, Rafael; Sancho, David; Rodríguez, Álvaro; Berenguer Ferrer, Marc; Sempere Torres, Daniel

    2014-01-01

    In this work we present WiBasin, a cloud platform for basin and dam management. It includes different sources of precipitation (both observed and forecasted), integration over the catchment domain (to provide an aggregated value of potential rainfall accumulated over the basin) , and a complete dissemination environment (web-viewer, capability of issuing hazard warnings with configurable thresholds, SMS, mails, etc.)

  16. Biomass Program 2007 Peer Review - Integrated Biorefinery Platform Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Integrated Biorefinery Platform Review held on August 13-15, 2007 in Golden, Colorado.

  17. Integration of the TNXYZ computer program inside the platform Salome

    International Nuclear Information System (INIS)

    The present work shows the procedure carried out to integrate the code TNXYZ as a calculation tool at the graphical simulation platform Salome. The TNXYZ code propose a numerical solution of the neutron transport equation, in several groups of energy, steady-state and three-dimensional geometry. In order to discretized the variables of the transport equation, the code uses the method of discrete ordinates for the angular variable, and a nodal method for the spatial dependence. The Salome platform is a graphical environment designed for building, editing and simulating mechanical models mainly focused on the industry and unlike other software, in order to form a complete scheme of pre and post processing of information, to integrate and control an external source code. Before the integration the in the Salome platform TNXYZ code was upgraded. TNXYZ was programmed in the 90s using Fortran 77 compiler; for this reason the code was adapted to the characteristics of the current Fortran compilers; in addition, with the intention of extracting partial results over the process sequence, the original structure of the program underwent a modularization process, i.e. the main program was divided into sections where the code performs major operations. This procedure is controlled by the information module (YACS) on Salome platform, and it could be useful for a subsequent coupling with thermal-hydraulics codes. Finally, with the help of the Monte Carlo code Serpent several study cases were defined in order to check the process of integration; the verification process consisted in performing a comparison of the results obtained with the code executed as stand-alone and after modernized, integrated and controlled by the Salome platform. (Author)

  18. Health Knowledge Effects: An Integrated Community Health Promotion Platform.

    Science.gov (United States)

    Chang, I-Chiu; Lin, Chih-Yu; Tseng, Hsiao-Ting; Ho, Wen-Yu

    2016-03-01

    The Taiwanese government subsidizes healthcare providers offering preventive medicine to patients to help reduce the threats of chronic sickness and halt skyrocketing medical expenditures. Usually, nurses are the primary workers who perform community health promotion; however, because of the chronic shortage of working nurses, many Taiwan hospitals have closed wards and deferred the responsibility of promoting primary prevention. With a community health promotion platform integrating interactive response features and Web sites for community patients and hospital staff, a case hospital efficiently sustained the community health services. The objective of this study was to assess the impact of the integrated community health promotion platform for conducting education. Fifty-four patients/residents were invited to join a quasi-experiment of health education, and a follow-up survey was conducted to assess the acceptance of the community health promotion platform from both the experimental group of learners/users and the hospital staff. The results showed that the community health promotion platform was effective in improving participant health awareness. The experimental group outperformed the control group, with higher posttest scores and longer knowledge retention. Furthermore, users indicated a high acceptance of the community health promotion platform. PMID:26657621

  19. Bio-chemical integrated recycling of hog manure

    Energy Technology Data Exchange (ETDEWEB)

    Levy, T.; Champagne, P.; Tudoret, M.J.; Dinel, H. [Carleton Univ., Ottawa, ON (Canada). Dept. of Civil and Environmental Engineering

    2003-07-01

    This paper presents a process by which hog manure can be used to generate agricultural products and chemical commodities. Excessive quantities of hog manure are generated with little acreage left for spreading the manure and nutrient recycling, which might result in pollution of surface and groundwater. The new proposed process is called bio-chemical integrated recycling (BCIR). The two main products generated are a non-hydrolyzed (NHP) and a hydrolyzed (HP) product. These products were assessed in batch, laboratory scale experiments, and were evaluated for total solids, volatile solids, percentage of carbon, percentage of nitrogen, and used spectral data from Fourier Transform Infrared Spectroscopy and Carbon 13-Nuclear Magnetic Resonance Spectroscopy. The results suggested that the NHP may be used as a substrate for ethanol production or organic acids, as it was mainly composed of carbohydrates, with sugar, starch and cellulose-like characteristics. The nature of HP was more complex. The percentage of volatile solids and nitrogen was higher than that of NHP. It appears that it might be used as an organic soil conditioner or fertilizer additive. An economic feasibility study is required before a final conclusion is made. 12 refs., 6 tabs.

  20. The Implementation of an Enterprise Application Integration Platform

    Institute of Scientific and Technical Information of China (English)

    XUJungang; WANGHongan; DAIGuozhong

    2004-01-01

    With the driving of rapid reaction to the changes of business rules, enterprises realize that they need to transfer their applications from single function to management of the whole processing flow. This transfer requires the enterprises to integrate the existing individual systems and re-configure its business systems. To meet this challenge, we have designed and implemented an Application integration platform for process industry (AIP/PI),which is model-driven and component-based, and composed of six main components: application configuration and execution platform, data accessing middleware, data collecting middleware, enterprise core database for production management, enterprise real-time database for production process, data integration and material balancing system. Our work has been applied to one refinery plant.

  1. Integrated instrument platform for in situ characterization of tank wastes

    International Nuclear Information System (INIS)

    An integrated instrument platform will support robotic characterization of radioactive chemical waste materials in the underground storage tanks at the Department of Energy's Hanford Site in Richland, Washington. The support platform supplies the basic support infrastructure needed to perform remotely controlled robotic deployment of sensors. A trailer serves as a field operations center, providing power and utilities, data acquisition and control equipment, common instrumentation, and test equipment. As part of the platform development effort, information on operational requirements and interface specifications is being compiled and distributed to potential suppliers of instrumentation. An overall characterization strategy has been developed, incorporating the currently identified characterization missions. This strategy will evolve over time and should provide a baseline to assist in planning for future deployment of characterization technology

  2. Wolfram technologies as an integrated scalable platform for interactive learning

    Science.gov (United States)

    Kaurov, Vitaliy

    2012-02-01

    We rely on technology profoundly with the prospect of even greater integration in the future. Well known challenges in education are a technology-inadequate curriculum and many software platforms that are difficult to scale or interconnect. We'll review an integrated technology, much of it free, that addresses these issues for individuals and small schools as well as for universities. Topics include: Mathematica, a programming environment that offers a diverse range of functionality; natural language programming for getting started quickly and accessing data from Wolfram|Alpha; quick and easy construction of interactive courseware and scientific applications; partnering with publishers to create interactive e-textbooks; course assistant apps for mobile platforms; the computable document format (CDF); teacher-student and student-student collaboration on interactive projects and web publishing at the Wolfram Demonstrations site.

  3. Voltage margin control for offshore multi-use platform integration

    OpenAIRE

    Mier, V.; Casielles, P.G.; Koto, J.; Zeni, Lorenzo

    2012-01-01

    This paper discusses a multiterminal direct current (MTDC) connection proposed for integration of offshore multi-use platforms into continental grids. Voltage source converters (VSC) were selected for their suitability for multiterminal dc systems and for their flexibility in control. A five terminal VSC-MTDC which includes offshore generation, storage, loads and ac connection, was modeled and simulated in DigSILENT Power Factory software. Voltage margin method has been used for reliable oper...

  4. Genomics Portals: integrative web-platform for mining genomics data

    Directory of Open Access Journals (Sweden)

    Ghosh Krishnendu

    2010-01-01

    Full Text Available Abstract Background A large amount of experimental data generated by modern high-throughput technologies is available through various public repositories. Our knowledge about molecular interaction networks, functional biological pathways and transcriptional regulatory modules is rapidly expanding, and is being organized in lists of functionally related genes. Jointly, these two sources of information hold a tremendous potential for gaining new insights into functioning of living systems. Results Genomics Portals platform integrates access to an extensive knowledge base and a large database of human, mouse, and rat genomics data with basic analytical visualization tools. It provides the context for analyzing and interpreting new experimental data and the tool for effective mining of a large number of publicly available genomics datasets stored in the back-end databases. The uniqueness of this platform lies in the volume and the diversity of genomics data that can be accessed and analyzed (gene expression, ChIP-chip, ChIP-seq, epigenomics, computationally predicted binding sites, etc, and the integration with an extensive knowledge base that can be used in such analysis. Conclusion The integrated access to primary genomics data, functional knowledge and analytical tools makes Genomics Portals platform a unique tool for interpreting results of new genomics experiments and for mining the vast amount of data stored in the Genomics Portals backend databases. Genomics Portals can be accessed and used freely at http://GenomicsPortals.org.

  5. Microarray Meta-Analysis and Cross-Platform Normalization: Integrative Genomics for Robust Biomarker Discovery

    OpenAIRE

    Walsh, Christopher J.; Pingzhao Hu; Jane Batt; dos Santos, Claudia C.

    2015-01-01

    The diagnostic and prognostic potential of the vast quantity of publicly-available microarray data has driven the development of methods for integrating the data from different microarray platforms. Cross-platform integration, when appropriately implemented, has been shown to improve reproducibility and robustness of gene signature biomarkers. Microarray platform integration can be conceptually divided into approaches that perform early stage integration (cross-platform normalization) versus ...

  6. REopt: A Platform for Energy System Integration and Optimization: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Simpkins, T.; Cutler, D.; Anderson, K.; Olis, D.; Elgqvist, E.; Callahan, M.; Walker, A.

    2014-08-01

    REopt is NREL's energy planning platform offering concurrent, multi-technology integration and optimization capabilities to help clients meet their cost savings and energy performance goals. The REopt platform provides techno-economic decision-support analysis throughout the energy planning process, from agency-level screening and macro planning to project development to energy asset operation. REopt employs an integrated approach to optimizing a site?s energy costs by considering electricity and thermal consumption, resource availability, complex tariff structures including time-of-use, demand and sell-back rates, incentives, net-metering, and interconnection limits. Formulated as a mixed integer linear program, REopt recommends an optimally-sized mix of conventional and renewable energy, and energy storage technologies; estimates the net present value associated with implementing those technologies; and provides the cost-optimal dispatch strategy for operating them at maximum economic efficiency. The REopt platform can be customized to address a variety of energy optimization scenarios including policy, microgrid, and operational energy applications. This paper presents the REopt techno-economic model along with two examples of recently completed analysis projects.

  7. Ultra-low temperature silicon nitride photonic integration platform.

    Science.gov (United States)

    Shao, Zengkai; Chen, Yujie; Chen, Hui; Zhang, Yanfeng; Zhang, Fangxing; Jian, Jian; Fan, Zeming; Liu, Lin; Yang, Chunchuan; Zhou, Lidan; Yu, Siyuan

    2016-02-01

    High-quality SiNx films with controllable low stress and low optical loss are deposited at ultra-low temperature (75 °C) using inductively coupled plasma chemical vapor deposition (ICP-CVD). Two kinds of integrated photonic structures have been demonstrated that exemplify its viability as a photonic integration platform. A microcavity consists of two distributed Bragg reflectors (DBR) formed by alternating a total of 49 layers of SiNx and SiO2 with a total thickness of about 11.5 μm is grown without any cracks, confirming the excellent stress control in the process. Microring resonators are also fabricated in as-deposited planar SiNx waveguide layer using electron-beam lithography (EBL) and plasma etching. Average waveguide loss of 0.79 ± 0.22 dB/cm has been achieved in the range of 1550-1600 nm for ring radii larger than 40 μm. The ultra-low temperature grown SiNx with properties of low loss and low stress is therefore a promising photonic integration platform for various photonic integration applications. PMID:26906765

  8. Integration of the program TNXYZ in the platform SALOME

    International Nuclear Information System (INIS)

    This work presents the procedure realized to integrate the code TNXYZ like a processing tool to the graphic simulation platform SALOME. The code TNXYZ solves the neutron transport equation in stationary state, for several energy groups, quantizing the angular variable by the discrete ordinates method and the space variable by nodal methods. The platform SALOME is a graphic surrounding designed for the construction, edition and simulation of mechanical models focused to the industry and contrary to other software, it allows to integrate external source codes to the surrounding, to form a complete scheme of execution, supervision, pre and post information processing. The code TNXYZ was programmed in the 90s in a Fortran compiler, but to be used at the present time the code should be actualized to the current compiler characteristics; also, in the original scheme was carried out a modularization process, that is to say, the main program was divided in sections where the code carries out important operations, with the intention of flexibility the data extraction process along its processing sequence and that can be useful in a later development of coupling. Finally, to verify the integration a fuel assembly BWR was modeled, as well as a control cell. The cross sections were obtained with the Monte Carlo Serpent code. Some results obtained with Serpent were used to verify and to begin with the validation of the code, being obtained an acceptable comparison in the infinite multiplication factor. The validation process should extend and one has planned to present in a future work. This work is part of the development of the research group formed between the Escuela Superior de Fisica y Matematicas del Instituto Politecnico Nacional (IPN) and the Instituto Nacional de Investigaciones Nucleares (ININ) in which a simulation Mexican platform of nuclear reactors is developed. (Author)

  9. Voltage margin control for offshore multi-use platform integration

    DEFF Research Database (Denmark)

    Mier, V.; Casielles, P.G.; Koto, J.;

    This paper discusses a multiterminal direct current (MTDC) connection proposed for integration of offshore multi-use platforms into continental grids. Voltage source converters (VSC) were selected for their suitability for multiterminal dc systems and for their flexibility in control. A five...... terminal VSC-MTDC which includes offshore generation, storage, loads and ac connection, was modeled and simulated in DigSILENT Power Factory software. Voltage margin method has been used for reliable operation of the MTDC system without the need of fast communication. Simulation results show that the......, sell or store energy attending to the price in the electricity market....

  10. Integration of fractal biosensor in a digital microfluidic platform

    KAUST Repository

    Mashraei, Yousof

    2015-11-01

    Fractal capacitive electrodes have been successfully integrated into a digital microfluidic open-platform. These electrodes perform actuation and withstand voltages up to 300V without insulation-layer breakdown. They were used to quantify the concentration levels of C-reactive protein (CRP) to determine the risk of cardiovascular disease. The capacitance increased sevenfold and stabilized in less than 5 minutes. The sensor shows a decreasing trend of capacitance readouts with the increase of concentrations. The same immunoassay was tested with untreated electrodes and showed no significant response, which suggests that immobilization was necessary. This configuration allows the electrodes to be used as biosensors.

  11. MeDICi: An Open Platform for Sensor Integration

    Energy Technology Data Exchange (ETDEWEB)

    Wynne, Adam S.; Gorton, Ian; Chase, Jared M.; Stephan, Eric G.

    2009-09-04

    MeDICi (Middleware for Data Intensive Computing) is a platform for developing high performance, distributed streaming analytic and scientific applications. Developed at Pacific Northwest National Laboratory (PNNL), MeDICi has been released under an open source license and is based on enterprise-proven middleware technologies including a widely used Enterprise Service Bus (ESB), the standard Business Process Execution Language (BPEL), and open source message brokers. Wherever possible, we have built on existing open source, standards-based systems and integrated them into a coherent whole by creating simplified graphical programming tools such as a Workflow Designer and an easy to use and well-documented integration API. This software development approach allows us to: avoid re-creating complex service integration and orchestration systems, reap the benefits of continual improvements to the technology base, and focus on creating tools and APIs which allow for the creation of re-usable component-based software components applications and workflows. These aspects have facilitated rapid adoption of the platform within PNNL for demonstration and operational applications. In fact, MeDICi has been used for a wide range of integration projects including two sensor integration applications described later on in this paper. The remainder of this article white paper is organized as follows: Section 2 provides a high-level description of the MeDICi architecture. In Section 3, the open aspects of the API and tool development are highlighted. Section 4 explains system readiness by presenting relevant demonstrations and deployments. Finally documentation and licensing details are provided in Section 5

  12. Lightweight Integrated Optical Sensor for Atmospheric Measurements on Mobile Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Parameswaran, Krishnan R. [Physical Sciences Inc.

    2013-12-02

    The goal of the Phase I program was to develop a novel open path sensor platform technology based on integration of semiconductor waveguides with efficient optoelectronic components on a monolithic platform. The successful Phase I effort resulted in demonstration of a novel optical resonator structure based on semiconductor high contrast gratings (HCGs) that will enable implementation of an ultra-compact, low-power gas sensor suitable for use on mobile platforms. Extensive numerical modeling was performed to design a device optimized for measuring CO2 at a wavelength for which a laser was available for proof of concept. Devices were fabricated and tested to match the target wavelength, angle, and operating temperature. This demonstration is the first implementation of HCGs at the wavelengths of interest and shows the flexibility of the proposed architecture for gas sensing applications. The measured cavity Q was lower than anticipated due to fabrication process challenges. The PSI and UC Berkeley team has identified solutions to these challenges and will produce optimized devices in a Phase II program where a prototype sensor will be fabricated and tested.

  13. Photonic Integration on the Hybrid Silicon Evanescent Device Platform

    Directory of Open Access Journals (Sweden)

    John E. Bowers

    2008-06-01

    Full Text Available This paper reviews the recent progress of hybrid silicon evanescent devices. The hybrid silicon evanescent device structure consists of III-V epitaxial layers transferred to silicon waveguides through a low-temperature wafer bonding process to achieve optical gain, absorption, and modulation efficiently on a silicon photonics platform. The low-temperature wafer bonding process enables fusion of two different material systems without degradation of material quality and is scalable to wafer-level bonding. Lasers, amplifiers, photodetectors, and modulators have been demonstrated with this hybrid structure and integration of these individual components for improved optical functionality is also presented. This approach provides a unique way to build photonic active devices on silicon and should allow application of silicon photonic integrated circuits to optical telecommunication and optical interconnects.

  14. Integration of Fractal Biosensor in a Digital Microfluidic Platform

    KAUST Repository

    Mashraei, Yousof

    2016-06-08

    The digital microfluidic (DMF) platform introduces many applications in biomedical assays. If it is to be commercially available to the public, it needs to have the essential features of smart sensing and a compact size. In this work, we report on a fractal electrode biosensor that is used for both droplet actuation and sensing C-reactive protein (CRP) concentration levels to assess cardiac disease risk. Our proposed electrode is the first two-terminal electrode design to be integrated into DMF platforms. A simulation of the electrical field distribution shows reduced peak intensities and uniform distribution of the field. When compared to a V-notch square electrode, the fractal electrode shows a superior performance in both aspects, i.e. field uniformity and intensity. These improvements are translated into a successful and responsive actuation of a water droplet with 100V. Likewise, the effective dielectric strength is improved by a 33% increase in the fractal electrode breakdown voltage. Additionally, the capability of the fractal electrode to work as a capacitive biosensor is evaluated with CRP quantification test. Selected fractal electrodes undergo a surface treatment to immobilize anti-CRP antibodies on their surface. The measurement shows a response to the added CRP in capacitance within three minutes. When the untreated electrodes were used for quantification, there was no significant change in capacitance, and this suggested that immobilization was necessary. The electrodes configuration in the fabricated DMF platform allows the fractal electrodes to be selectively used as biosensors, which means the device could be integrated into point-of-care applications.

  15. Electronic-photonic integrated circuits on the CMOS platform

    Science.gov (United States)

    Kimerling, L. C.; Ahn, D.; Apsel, A. B.; Beals, M.; Carothers, D.; Chen, Y.-K.; Conway, T.; Gill, D. M.; Grove, M.; Hong, C.-Y.; Lipson, M.; Liu, J.; Michel, J.; Pan, D.; Patel, S. S.; Pomerene, A. T.; Rasras, M.; Sparacin, D. K.; Tu, K.-Y.; White, A. E.; Wong, C. W.

    2006-02-01

    The optical components industry stands at the threshold of a major expansion that will restructure its business processes and sustain its profitability for the next three decades. This growth will establish a cost effective platform for the partitioning of electronic and photonic functionality to extend the processing power of integrated circuits. BAE Systems, Lucent Technologies, Massachusetts Institute of Technology, and Applied Wave Research are participating in a high payoff research and development program for the Microsystems Technology Office (MTO) of DARPA. The goal of the program is the development of technologies and design tools necessary to fabricate an application-specific, electronicphotonic integrated circuit (AS-EPIC). As part of the development of this demonstration platform we are exploring selected functions normally associated with the front end of mixed signal receivers such as modulation, detection, and filtering. The chip will be fabricated in the BAE Systems CMOS foundry and at MIT's Microphotonics Center. We will present the latest results on the performance of multi-layer deposited High Index Contrast Waveguides, CMOS compatible modulators and detectors, and optical filter slices. These advances will be discussed in the context of the Communications Technology Roadmap that was recently released by the MIT Microphotonics Center Industry Consortium.

  16. An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities.

    Science.gov (United States)

    Choi, Jin-Woo; Oh, Kwang W; Thomas, Jennifer H; Heineman, William R; Halsall, H Brian; Nevin, Joseph H; Helmicki, Arthur J; Henderson, H Thurman; Ahn, Chong H

    2002-02-01

    This paper presents the development and characterization of an integrated microfluidic biochemical detection system for fast and low-volume immunoassays using magnetic beads, which are used as both immobilization surfaces and bio-molecule carriers. Microfluidic components have been developed and integrated to construct a microfluidic biochemical detection system. Magnetic bead-based immunoassay, as a typical example of biochemical detection and analysis, has been successfully performed on the integrated microfluidic biochemical analysis system that includes a surface-mounted biofilter and electrochemical sensor on a glass microfluidic motherboard. Total time required for an immunoassay was less than 20 min including sample incubation time, and sample volume wasted was less than 50 microl during five repeated assays. Fast and low-volume biochemical analysis has been successfully achieved with the developed biofilter and immunosensor, which is integrated to the microfluidic system. Such a magnetic bead-based biochemical detection system, described in this paper, can be applied to protein analysis systems. PMID:15100857

  17. The Cytochrome P450 Engineering Database: integration of biochemical properties

    Directory of Open Access Journals (Sweden)

    Lisitsa Andrey

    2009-11-01

    Full Text Available Abstract Background Cytochrome P450 monooxygenases (CYPs form a vast and diverse enzyme class of particular interest in drug development and a high biotechnological potential. Although very diverse in sequence, they share a common structural fold. For the comprehensive and systematic comparison of protein sequences and structures the Cytochrome P450 Engineering Database (CYPED was established. It was built up based on an extensible data model that enables its functions readily enhanced. Description The new version of the CYPED contains information on sequences and structures of 8613 and 47 proteins, respectively, which strictly follow Nelson's classification rules for homologous families and superfamilies. To gain biochemical information on substrates and inhibitors, the CYPED was linked to the Cytochrome P450 Knowledgebase (CPK. To overcome differences in the data model and inconsistencies in the content of CYPED and CPK, a metric was established based on sequence similarity to link protein sequences as primary keys. In addition, the annotation of structurally and functionally relevant residues was extended by a reliable prediction of conserved secondary structure elements and by information on the effect of single nucleotide polymorphisms. Conclusion The online accessible version of the CYPED at http://www.cyped.uni-stuttgart.de provides a valuable tool for the analysis of sequences, structures and their relationships to biochemical properties.

  18. Microarray Meta-Analysis and Cross-Platform Normalization: Integrative Genomics for Robust Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    Christopher J. Walsh

    2015-08-01

    Full Text Available The diagnostic and prognostic potential of the vast quantity of publicly-available microarray data has driven the development of methods for integrating the data from different microarray platforms. Cross-platform integration, when appropriately implemented, has been shown to improve reproducibility and robustness of gene signature biomarkers. Microarray platform integration can be conceptually divided into approaches that perform early stage integration (cross-platform normalization versus late stage data integration (meta-analysis. A growing number of statistical methods and associated software for platform integration are available to the user, however an understanding of their comparative performance and potential pitfalls is critical for best implementation. In this review we provide evidence-based, practical guidance to researchers performing cross-platform integration, particularly with an objective to discover biomarkers.

  19. INsPeCT: INtegrative Platform for Cancer Transcriptomics.

    Science.gov (United States)

    Madhamshettiwar, Piyush B; Maetschke, Stefan R; Davis, Melissa J; Reverter, Antonio; Ragan, Mark A

    2014-01-01

    The emergence of transcriptomics, fuelled by high-throughput sequencing technologies, has changed the nature of cancer research and resulted in a massive accumulation of data. Computational analysis, integration, and data visualization are now major bottlenecks in cancer biology and translational research. Although many tools have been brought to bear on these problems, their use remains unnecessarily restricted to computational biologists, as many tools require scripting skills, data infrastructure, and powerful computational facilities. New user-friendly, integrative, and automated analytical approaches are required to make computational methods more generally useful to the research community. Here we present INsPeCT (INtegrative Platform for Cancer Transcriptomics), which allows users with basic computer skills to perform comprehensive in-silico analyses of microarray, ChIP-seq, and RNA-seq data. INsPeCT supports the selection of interesting genes for advanced functional analysis. Included in its automated workflows are (i) a novel analytical framework, RMaNI (regulatory module network inference), which supports the inference of cancer subtype-specific transcriptional module networks and the analysis of modules; and (ii) WGCNA (weighted gene co-expression network analysis), which infers modules of highly correlated genes across microarray samples, associated with sample traits, eg survival time. INsPeCT is available free of cost from Bioinformatics Resource Australia-EMBL and can be accessed at http://inspect.braembl.org.au. PMID:24653643

  20. TECHNOLOGY SUPPORTED LEARNING PLATFORM: Moodle Integrated Academic Course

    Directory of Open Access Journals (Sweden)

    Saziye YAMAN

    2010-04-01

    Full Text Available It is substantially accepted that constructivism proposes knowledge as “not a fixed object”; constructed by an individual through her own experiences. As a learning theory, constructivism in education emphasizes collaborative learning, such as authentic challenging projects involving in students, teachers and experts in the learning community. Its goal is to create learning communities that are more closely related to the collaborative practice of the real world as strongly reflected in social constructivist idea. The technologies used in the filed of education will support learning through collaborative practices, using learners’ experiences for “meaning making”. The challenge now is to extend the educational networks so that it offers access to learning resources, online storage and tools for communication and management not just within the limitation of school and time. Through learning platforms, such as Moodle, teachers and administrators may bring hardware, software and supporting services together to enable more effective conditions among teachers and students. In this study, Moodle was used to support the 4th grade pre-service language teachers’ (student teachers one of the academic courses, named as “Field Experience”. The student teachers were expected to prepare graduation theses in the field of English language teaching. Moodle was integrated as a technological learning aid and used as online support throughout a semester course. So, we will discuss how Moodle was integrated as a learning platform, while discussing, the use of Moodle as a “course supporter” process, steps and the sample activities will be presented as well.

  1. Turbine blade and non-integral platform with pin attachment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Christian Xavier; Eng, Darryl; Marra, John J.

    2016-08-02

    Platforms (36, 38) span between turbine blades (23, 24, 25) on a disk (32). Each platform may be individually mounted to the disk by a pin attachment (42). Each platform (36) may have a rotationally rearward edge portion (50) that underlies a forward portion (45) of the adjacent platform (38). This limits centrifugal bending of the rearward portion of the platform, and provides coolant sealing. The rotationally forward edge (44A, 44B) of the platform overlies a seal element (51) on the pressure side (28) of the forwardly adjacent blade, and does not underlie a shelf on that blade. The pin attachment allows radial mounting of each platform onto the disk via tilting (60) of the platform during mounting to provide mounting clearance for the rotationally rearward edge portion (50). This facilitates quick platform replacement without blade removal.

  2. Integrase and integration: biochemical activities of HIV-1 integrase

    Directory of Open Access Journals (Sweden)

    Deprez Eric

    2008-12-01

    Full Text Available Abstract Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration. The process of integration can be divided into two sequential reactions. The first one, named 3'-processing, corresponds to a specific endonucleolytic reaction which prepares the viral DNA extremities to be competent for the subsequent covalent insertion, named strand transfer, into the host cell genome by a trans-esterification reaction. Recently, a novel specific activity of the full length integrase was reported, in vitro, by our group for two retroviral integrases (HIV-1 and PFV-1. This activity of internal cleavage occurs at a specific palindromic sequence mimicking the LTR-LTR junction described into the 2-LTR circles which are peculiar viral DNA forms found during viral infection. Moreover, recent studies demonstrated the existence of a weak palindromic consensus found at the integration sites. Taken together, these data underline the propensity of retroviral integrases for binding symmetrical sequences and give perspectives for targeting specific sequences used for gene therapy.

  3. TB database: an integrated platform for tuberculosis research.

    Science.gov (United States)

    Reddy, T B K; Riley, Robert; Wymore, Farrell; Montgomery, Phillip; DeCaprio, Dave; Engels, Reinhard; Gellesch, Marcel; Hubble, Jeremy; Jen, Dennis; Jin, Heng; Koehrsen, Michael; Larson, Lisa; Mao, Maria; Nitzberg, Michael; Sisk, Peter; Stolte, Christian; Weiner, Brian; White, Jared; Zachariah, Zachariah K; Sherlock, Gavin; Galagan, James E; Ball, Catherine A; Schoolnik, Gary K

    2009-01-01

    The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers. The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M. tuberculosis and its close relatives. TBDB currently hosts data for nearly 1500 public tuberculosis microarrays and 260 arrays for Streptomyces. In addition, TBDB provides access to a suite of comparative genomics and microarray analysis software. By bringing together M. tuberculosis genome annotation and gene-expression data with a suite of analysis tools, TBDB (http://www.tbdb.org/) provides a unique discovery platform for TB research. PMID:18835847

  4. Hybrid integrated photonic components based on a polymer platform

    Science.gov (United States)

    Eldada, Louay A.

    2003-06-01

    We report on a polymer-on-silicon optical bench platform that enables the hybrid integration of elemental passive and active optical functions. Planar polymer circuits are produced photolithographically, and slots are formed in them for the insertion of chips and films of a variety of materials. The polymer circuits provide interconnects, static routing elements such as couplers, taps, and multi/demultiplexers, as well as thermo-optically dynamic elements such as switches, variable optical attenuators, and tunable notch filters. Crystal-ion-sliced thin films of lithium niobate are inserted in the polymer circuit for polarization control or for electro-optic modulation. Films of yttrium iron garnet and neodymium iron boron magnets are inserted in order to magneto-optically achieve non-reciprocal operation for isolation and circulation. Indium phosphide and gallium arsenide chips are inserted for light generation, amplification, and detection, as well as wavelength conversion. The functions enabled by this multi-material platform span the range of the building blocks needed in optical circuits, while using the highest-performance material system for each function. We demonstrated complex-functionality photonic components based on this technology, including a metro ring node module and a tunable optical transmitter. The metro ring node chip includes switches, variable optical attenuators, taps, and detectors; it enables optical add/drop multiplexing, power monitoring, and automatic load balancing, and it supports shared and dedicated protection protocols in two-fiber metro ring optical networks. The tunable optical transmitter chip includes a tunable external cavity laser, an isolator, and a high-speed modulator.

  5. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks.

    Science.gov (United States)

    Biffi, Emilia; Piraino, Francesco; Pedrocchi, Alessandra; Fiore, Gianfranco B; Ferrigno, Giancarlo; Redaelli, Alberto; Menegon, Andrea; Rasponi, Marco

    2012-06-01

    Spatially and temporally resolved delivery of soluble factors is a key feature for pharmacological applications. In this framework, microfluidics coupled to multisite electrophysiology offers great advantages in neuropharmacology and toxicology. In this work, a microfluidic device for biochemical stimulation of neuronal networks was developed. A micro-chamber for cell culturing, previously developed and tested for long term neuronal growth by our group, was provided with a thin wall, which partially divided the cell culture region in two sub-compartments. The device was reversibly coupled to a flat micro electrode array and used to culture primary neurons in the same microenvironment. We demonstrated that the two fluidically connected compartments were able to originate two parallel neuronal networks with similar electrophysiological activity but functionally independent. Furthermore, the device allowed to connect the outlet port to a syringe pump and to transform the static culture chamber in a perfused one. At 14 days invitro, sub-networks were independently stimulated with a test molecule, tetrodotoxin, a neurotoxin known to block action potentials, by means of continuous delivery. Electrical activity recordings proved the ability of the device configuration to selectively stimulate each neuronal network individually. The proposed microfluidic approach represents an innovative methodology to perform biological, pharmacological, and electrophysiological experiments on neuronal networks. Indeed, it allows for controlled delivery of substances to cells, and it overcomes the limitations due to standard drug stimulation techniques. Finally, the twin network configuration reduces biological variability, which has important outcomes on pharmacological and drug screening. PMID:22655017

  6. To design and construct an embedded knowledge integration service platform:Taking ISCAS subject group platform as an example

    Institute of Scientific and Technical Information of China (English)

    Yajing; LIU; Jinhui; ZHOU; Yanxi; WANG; Dan; HAO

    2014-01-01

    Purpose:As scientific resources are widely distributed,researchers often have difficulties in acquiring information from different individual sources.This paper intends to present a new approach to construct a subject-knowledge-based integration platform which was carried out by the Institute of Software,Chinese Academy of Sciences(ISCAS).Our aim is to use technique tools to strengthen the library service by combining a variety of information service resources with knowledge tools.Design/methodology/approach:Based on the analysis of users’ needs,we established a collaborative team across ISCAS Library,National Science Library of CAS(NSL CAS),and ISCAS’ research groups or research labs.With the service tools developed by ISCAS Library,we embedded other multipurpose utility tools of knowledge integration into the platform as to make full use of software tools in knowledge integration,knowledge fusion,and intelligent push of library services to end users.Findings:With a hard effort of the construction team,the ISCAS subject group platform(hereinafter as ISCAS Platform) has integrated such information resources as institutional repository(IR) of ISCAS,open resources from websites and subject resources of computer sciences.Up to date,ISCAS platform can provide integrated information services including data collection for computer science and intelligent generation of citation reports,by means of embedding self-developed discovering tools for domain experts and subject content,and generation tools for scientific citation reports.Research limitations:Knowledge organization need be further improved in the ISCAS subject group platform.In addition,functions for academic exchanges need be maximized as to meet the individual demands of researchers for library services at the Platform.Practical implications:Since we Platform has been put into use through the Library website of the ISCAS in June 2012,many academic libraries from both domestic universities and CAS institutes

  7. VOLTTRON Lite: Integration Platform for the Transactional Network

    Energy Technology Data Exchange (ETDEWEB)

    Haack, Jereme N.; Katipamula, Srinivas; Akyol, Bora A.; Lutes, Robert G.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform. The platform is intended to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop units (RTUs) and the electric grid using applications or “agents” that reside on the platform, on the equipment, on local building controller or in the Cloud. This document describes the core of the transactional network platform, the Volttron Lite™ software and associated services hosted on the platform. Future enhancements are also discussed. The appendix of the document provides examples of how to use the various services hosted on the platform.

  8. An integrated platform for assessing biologics (Conference Presentation)

    Science.gov (United States)

    Schein, Perry; O'Dell, Dakota; Erickson, David

    2016-04-01

    Protein therapeutics are a rapidly growing portion of the pharmaceuticals market and have many significant advantages over traditional small molecule drugs. As this market expands, however, critical regulatory and quality control issues remain, most notably the problem of protein aggregation. Individual target proteins often aggregate into larger masses which trigger an immune response in the body, which can reduce the efficacy of the drug for its intended purpose, or cause serious anaphylactic side-effects. Although detecting and minimizing aggregate formation is critical to ensure an effective product, aggregation dynamics are often highly complicated and there is little hope of reliable prediction and prevention from first principles. This problem is compounded for aggregates in the subvisible range of 100 nm to 10 micrometers where traditional techniques for detecting aggregates have significant limitations. Here, we present an integrated optofluidic platform for detecting nanoscale protein aggregates and characterizing interactions between these aggregates and a reference surface. By delivering light to a solution of proteins with an optical waveguide, scattered light from individual protein aggregates can be detected and analyzed to determine the force profile between each particle and the waveguide surface. Unlike existing methods which only determine size or charge, our label-free screening technique can directly measure the surface interaction forces between single aggregates and the glass substrate. This direct measurement capability may allow for better empirical predictions of the stability of protein aggregates during drug manufacturing and storage.

  9. a Workflow for UAV's Integration Into a Geodesign Platform

    Science.gov (United States)

    Anca, P.; Calugaru, A.; Alixandroae, I.; Nazarie, R.

    2016-06-01

    This paper presents a workflow for the development of various Geodesign scenarios. The subject is important in the context of identifying patterns and designing solutions for a Smart City with optimized public transportation, efficient buildings, efficient utilities, recreational facilities a.s.o.. The workflow describes the procedures starting with acquiring data in the field, data processing, orthophoto generation, DTM generation, integration into a GIS platform and analyzing for a better support for Geodesign. Esri's City Engine is used mostly for 3D modeling capabilities that enable the user to obtain 3D realistic models. The workflow uses as inputs information extracted from images acquired using UAVs technologies, namely eBee, existing 2D GIS geodatabases, and a set of CGA rules. The method that we used further, is called procedural modeling, and uses rules in order to extrude buildings, the street network, parcel zoning and side details, based on the initial attributes from the geodatabase. The resulted products are various scenarios for redesigning, for analyzing new exploitation sites. Finally, these scenarios can be published as interactive web scenes for internal, groups or pubic consultation. In this way, problems like the impact of new constructions being build, re-arranging green spaces or changing routes for public transportation, etc. are revealed through impact and visibility analysis or shadowing analysis and are brought to the citizen's attention. This leads to better decisions.

  10. Future of Hydroinformatics: Towards Open, Integrated and Interactive Online Platforms

    Science.gov (United States)

    Demir, I.; Krajewski, W. F.

    2012-12-01

    Hydroinformatics is a domain of science and technology dealing with the management of information in the field of hydrology (IWA, 2011). There is the need for innovative solutions to the challenges towards open information, integration, and communication in the Internet. This presentation provides an overview of the trends and challenges in the future of hydroinformatics, and demonstrates an information system, Iowa Flood Information System (IFIS), developed within the light of these challenges. The IFIS is a web-based platform developed by the Iowa Flood Center (IFC) to provide access to flood inundation maps, real-time flood conditions, flood forecasts both short-term and seasonal, flood-related data, information and interactive visualizations for communities in Iowa. The key element of the system's architecture is the notion of community. Locations of the communities, those near streams and rivers, define basin boundaries. The IFIS provides community-centric watershed and river characteristics, weather (rainfall) conditions, and streamflow data and visualization tools. Interactive interfaces allow access to inundation maps for different stage and return period values, and flooding scenarios with contributions from multiple rivers. Real-time and historical data of water levels, gauge heights, and rainfall conditions are available in the IFIS by streaming data from automated IFC bridge sensors, USGS stream gauges, NEXRAD radars, and NWS forecasts. 2D and 3D interactive visualizations in the IFIS make the data more understandable to general public. Users are able to filter data sources for their communities and selected rivers. The data and information on IFIS is also accessible through web services and mobile applications. The IFIS is optimized for various browsers and screen sizes to provide access through multiple platforms including tablets and mobile devices. The IFIS includes a rainfall-runoff forecast model to provide a five-day flood risk estimate for more

  11. Mars Science Laboratory: An Integrated Platform for Exploration and Sampling

    Science.gov (United States)

    Vasavada, A. R.; Mars Science Laboratory Science Team

    2011-12-01

    The Mars Science Laboratory mission delivers the Curiosity rover to the surface of Mars in August 2012 to assess whether its Gale Crater field site ever was capable of supporting microbial life and preserving a record of life and past environmental conditions. The 150-km crater is one of many near Mars' dichotomy boundary in various states of exhumation as a result of massive regional deposition and erosion. The primary target for Curiosity is the 5-km high mound of stratified materials in the crater's center. Systematic variations in mineralogy and morphology through the section indicate that the sediments have witnessed major changes in regional, if not planetary processes, as far back as the Noachian. The Curiosity rover was conceived as both a robotic field geologist, as previous rovers, and a mobile geochemical laboratory. It is an integrated platform for exploration (via landing site accessibility and mobility), for monitoring (via meteorological and high-energy radiation sensors), for survey (via panoramic cameras and remote elemental analysis), for close inspection (via a hand-lens imager and contact spectrometer), and for geochemical sample analysis. The latter capability drives the size and complexity of the rover by requiring a sample acquisition, processing, and analysis system consisting of a 2-m robot arm, rotary percussion drill, sieves and portioning tools, and the analytical instruments themselves. Upon acquisition and processing, samples of powdered rock are delivered to instruments located inside the rover body for mineralogical identification using X-ray diffraction, and analysis of elemental, molecular, and isotopic composition (including organic compounds) using a combined mass spectrometer, gas chromatograph, and tunable-laser spectrometer suite. To ensure the quality and accuracy of measurements from these instruments, and their interpretation, the mission has met many challenges in areas such as organic cleanliness, control blanks, tool and

  12. 2011 Biomass Program Platform Peer Review. Integrated Biorefineries

    Energy Technology Data Exchange (ETDEWEB)

    Rossmeissl, Neil [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s IBR Platform Review meeting.

  13. Mobile device platforms and servitization: towards an integrative model

    OpenAIRE

    Jaría Chacón, Natalia; Arias Aranda, Daniel

    2014-01-01

    Together with the rapid development of new platforms for mobile devices, the servitization process is constantly evolving in the design and development of products and services that respond almost instantly to customers' changing needs and desires. In the field of mobile devices this process has been attached to the development of specific applications for both open and closed platforms. However, the advance of technology currently allows for the provision of broader services through open pla...

  14. Integration of wireless communications in a GIS platform

    OpenAIRE

    Casademont Serra, Jordi; López Aguilera, M. Elena; Paradells Aspas, Josep

    2002-01-01

    This paper presents a new developed platform for the Commercialisation of Advanced Services of Geographical Information, focussed in portables devices, and that makes use of the telecommunication networks available today: Internet as the backbone and cellular networks (GSM + GPRS) as access networks. The platform implements a system for commercialising cartographic information in form of vectorial maps for different amount of time, guarantying property rights of the provided informat...

  15. A CORBA-Based Integration Platform of Product Development Process Management for Concurrent Engineering

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and inte gration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is de signed and developed. The design principles for IP-PDPM are described. The system architecture and func tions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.

  16. Reference model for the integration of infrastructure- and platform-level clouds

    OpenAIRE

    Dukarić, Robert

    2014-01-01

    Cloud computing is revolutionizing the IT industry by enabling access to infrastructure, platform and applications as services. Due to the vast diversity of existing IaaS (Infrastructure as a Service) and PaaS (Platform as a Service) clouds, the development and execution of contemporary cloud-based applications is significantly hindered. Therefore, the goal of this thesis is to design a reference model for the integration of infrastructure- and platform-level clouds, which we structure into t...

  17. Design and Analysis of a Compact Precision Positioning Platform Integrating Strain Gauges and the Piezoactuator

    OpenAIRE

    Shunguang Wan; Zhichao Ma; Chengli Shi; Zunqiang Fan; Zhaojun Yang; Hongwei Zhao; Hu Huang

    2012-01-01

    Miniaturization precision positioning platforms are needed for in situ nanomechanical test applications. This paper proposes a compact precision positioning platform integrating strain gauges and the piezoactuator. Effects of geometric parameters of two parallel plates on Von Mises stress distribution as well as static and dynamic characteristics of the platform were studied by the finite element method. Results of the calibration experiment indicate that the strain gauge...

  18. SOA, SoBI & EDA - Paradigms for Integration Capabilities of BI Platform

    Directory of Open Access Journals (Sweden)

    Bogdan GHILIC-MICU

    2008-01-01

    Full Text Available A Business Intelligence (BI provider may offer a basic solution, a packed application or a comprising BI platform which integrates components from individual technologies in a synergic system. The providers’ tendency is to standardize the instruments offered on a single server platform. The article analyzes the integration capabilities and problems of BI platforms, emphasizes the differences between emergent technologies and suggests integration solutions. The analysis is useful both to the providers of BI solutions - in order to develop some agile platforms, as well as to their users - representing an important factor in selecting the solution. In addition, the conclusions to be drawn will emphasize the tendencies from the BI market and will represent the support in creating some agile platforms.

  19. Vane array with one or more non-integral platforms

    Science.gov (United States)

    Lohaus, Andrew S.; Campbell, Christian Xavier; Miller, Jr, Samuel R.; Marra, John J.

    2016-07-12

    A vane array adapted to be coupled to a vane carrier within a gas turbine engine is provided comprising: a plurality of elongated airfoils comprising at least a first airfoil and a second airfoil located adjacent to one another; a U-ring; first connector structure for coupling a radially inner end section of each of the first and second airfoils to the U-ring; second connector structure for coupling a radially outer end section of each of the first and second airfoils to the vane carrier; a platform extending between the first and second airfoils; and platform connector structure for coupling the platform to one of the U-ring and the vane carrier.

  20. Development and Integration of a Pulsed 2-micron Direct Detection Integrated Path Differential Absorption (IPDA) Lidar for CO2 Column Measurement from Airborne platform Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop, integrate and demonstrate a 2-micron pulsed Integrated Path Differential Absorption Lidar (IPDA) instrument CO2 Column Measurement from Airborne platform...

  1. Integrating Software Architecture Concepts into the MDA Platform with UML Profile

    Directory of Open Access Journals (Sweden)

    Adel Alti

    2007-01-01

    Full Text Available Architecture Description Languages (ADLs provide an abstract representation of software systems. Achieving a concrete mapping of such representation into the implementation is one of the principal aspects of MDA (Model Driven Architecture. Integration of ADLs within MDA confers to the MDA platform a higher level of abstraction and a degree of reuse of ADLs. Indeed they have significantly different platform metamodels which make the definition of mapping rules complex. This complexity is clearly noticeable when some software architecture concepts cannot be easily mapped to MDA platform. In this research, we propose to integrate software architecture within MDA. We define also strategy for direct transformation using a UML profile. It represents both software architecture model (PIM and MDA platform model (PSM in UML meta-model then elaborates transformation rules between results UML meta-models. The goal is to automate the process of deriving implementation platform from software concepts.

  2. Multiple-platform data integration method with application to combined analysis of microarray and proteomic data

    Directory of Open Access Journals (Sweden)

    Wu Shicheng

    2012-12-01

    Full Text Available Abstract Background It is desirable in genomic studies to select biomarkers that differentiate between normal and diseased populations based on related data sets from different platforms, including microarray expression and proteomic data. Most recently developed integration methods focus on correlation analyses between gene and protein expression profiles. The correlation methods select biomarkers with concordant behavior across two platforms but do not directly select differentially expressed biomarkers. Other integration methods have been proposed to combine statistical evidence in terms of ranks and p-values, but they do not account for the dependency relationships among the data across platforms. Results In this paper, we propose an integration method to perform hypothesis testing and biomarkers selection based on multi-platform data sets observed from normal and diseased populations. The types of test statistics can vary across the platforms and their marginal distributions can be different. The observed test statistics are aggregated across different data platforms in a weighted scheme, where the weights take into account different variabilities possessed by test statistics. The overall decision is based on the empirical distribution of the aggregated statistic obtained through random permutations. Conclusion In both simulation studies and real biological data analyses, our proposed method of multi-platform integration has better control over false discovery rates and higher positive selection rates than the uncombined method. The proposed method is also shown to be more powerful than rank aggregation method.

  3. New CMOS Compatible Platforms for Integrated Nonlinear Optical Signal Processing

    CERN Document Server

    Moss, D J

    2014-01-01

    Nonlinear photonic chips have succeeded in generating and processing signals all-optically with performance far superior to that possible electronically - particularly with respect to speed. Although silicon-on-insulator has been the leading platform for nonlinear optics, its high two-photon absorption at telecommunications wavelengths poses a fundamental limitation. This paper reviews some of the recent achievements in CMOS-compatible platforms for nonlinear optics, focusing on amorphous silicon and Hydex glass, highlighting their potential future impact as well as the challenges to achieving practical solutions for many key applications. These material systems have opened up many new capabilities such as on-chip optical frequency comb generation and ultrafast optical pulse generation and measurement.

  4. Third-party Reverse logistics platform and method Based on Bilateral Resource Integration

    Directory of Open Access Journals (Sweden)

    Zheng Hong Zhen

    2016-01-01

    Full Text Available Dispersion of reverse logistics resources makes it difficult to create relationships between demanders and providers, thereby the personalized demand for the construction of enterprise reverse logistics cannot be satisfied and the service quality cannot be guaranteed. Aiming at these problems, this paper presents a platform and method of enterprise reverse logistics based on bilateral resource integration (RLBRI. The method creates a third-party reverse logistics platform to accumulate a mass of reverse logistics demanders and providers together. And the platform integrates bilateral resources and acts as an intermediary to establish relationships between two sides. Through the platform, a complete and high-quality business chain for enterprise reverse logistics will be built efficiently. Finally put forward an effective strategy of non-defective reverse logistics depends on the integrity checking service provided by third-party logistics. By using this strategy it can short the distance of non-defective reverse transportation. Computational tests validate the strategy.

  5. An electrodynamic preconcentrator integrated thermoelectric biosensor chip for continuous monitoring of biochemical process

    International Nuclear Information System (INIS)

    This paper proposes an integrated sensor chip for continuous monitoring of a biochemical process. It is composed of a preconcentrator and a thermoelectric biosensor. In the preconcentrator, the concentration of the injected biochemical sample is electrodynamically condensed. Then, in the downstream thermoelectric biosensor, the preconcentrated target molecules react with sequentially injected capture molecules and generate reaction heat. The reaction heat is detected based on the thermoelectric effect, and an integrated split-flow microchannel improves the sensor stability by providing ability to self-compensate thermal noise. These sequential preconcentration and detection processes are performed in completely label-free and continuous conditions and consequently enhance the sensor sensitivity. The performance of the integrated biosensor chip was evaluated at various flow rates and applied voltages. First, in order to verify characteristics of the fabricated preconcentrator, 10 µm -diameter polystyrene (PS) particles were used. The particles were concentrated by applying ac voltage from 0 to 16 Vpp at 3 MHz at various flow rates. In the experimental result, approximately 92.8% of concentration efficiency was achieved at a voltage over 16 Vpp and at a flow rate below 100 µl h−1. The downstream thermoelectric biosensor was characterized by measuring reaction heat of biotin–streptavidin interaction. The preconcentrated streptavidin-coated PS particles flow into the reaction chamber and react with titrated biotin. The measured output voltage was 288.2 µV at a flow rate of 100 µl h−1 without preconcentration. However, by using proposed preconcentrator, an output voltage of 812.3 µV was achieved with a 16 Vpp-applied preconcentration in the same given sample and flow rate. According to these results, the proposed label-free biomolecular preconcentration and detection technique can be applied in continuous and high-throughput biochemical applications. (paper)

  6. Integration of modelica-based models with the JModelica Platform

    OpenAIRE

    Kraus Cabo, Daniel

    2013-01-01

    In this thesis, an introduction to Nonlinear Model Predictive Control (NMPC) combining both theory and application is presented. The basis of the NMPC is described to give a general idea how this process control strategy works. For this purpose, two test casestudies are implemented. The first one is a simple two tanks in series to get acquainted with open-source platform the JModelica.org and the Optimica extension.Finally, a more complex example, which consists of solving a start-up probl...

  7. Enhancing Mobility: Integrating New Services into Your Library's Mobile Platform to Increase Traffic

    Science.gov (United States)

    Felts, John W., Jr.

    2014-01-01

    Kimbel Library launched its mobile environment and ran it in full production for several months yet usage patterns were quite low and flat. The library only saw a substantial increase in usage when new, value-added services were integrated into this platform. Upon implementing and integrating discovery services, chat and SMS capabilities, and…

  8. Integrated Alignment and Inspection Platform for High Precision Optical Continuous Images

    Directory of Open Access Journals (Sweden)

    Chuen-Horng Lin

    2014-11-01

    Full Text Available This platform is mainly intended to be used as a facility for high precision optical continuous images. Then, with a fixed pattern being selected, this platform can quickly search, with resistance to variation, the mark that corresponds to the pattern in order to achieve the alignment and inspection target. Since the pattern is a minute component with multiple shapes and unstable features, this platform can automatically acquire it through the system or select it by user. The targets searched by the mark include light, intensity, occlusion and rotation. It then, calculates the variances of light, intensity, occlusion and rotation individually with the mark under detection, search and pattern to achieve the inspection function. Therefore, combined with a quick and accurate mark detection and the search method, this platform builds an interface integrated platform that is easy to operate and user-friendly.

  9. An integrated platform for directly widely-targeted quantitative analysis of feces part I: Platform configuration and method validation.

    Science.gov (United States)

    Song, Yuelin; Song, Qingqing; Li, Jun; Zheng, Jiao; Li, Chun; Zhang, Yuan; Zhang, Lingling; Jiang, Yong; Tu, Pengfei

    2016-07-01

    Direct analysis is of great importance to understand the real chemical profile of a given sample, notably biological materials, because either chemical degradation or diverse errors and uncertainties might be resulted from sophisticated protocols. In comparison with biofluids, it is still challenging for direct analysis of solid biological samples using high performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Herein, a new analytical platform was configured by online hyphenating pressurized liquid extraction (PLE), turbulent flow chromatography (TFC), and LC-MS/MS. A facile, but robust PLE module was constructed based on the phenomenon that noticeable back-pressure can be generated during rapid fluid passing through a narrow tube. TFC column that is advantageous at extracting low molecular analytes from rushing fluid was employed to link at the outlet of the PLE module to capture constituents-of-interest. An electronic 6-port/2-position valve was introduced between TFC column and LC-MS/MS to fragment each measurement into extraction and elution phases, whereas LC-MS/MS took the charge of analyte separation and monitoring. As a proof of concept, simultaneous determination of 24 endogenous substances including eighteen steroids, five eicosanoids, and one porphyrin in feces was carried out in this paper. Method validation assays demonstrated the analytical platform to be qualified for directly simultaneous measurement of diverse endogenous analytes in fecal matrices. Application of this integrated platform on homolog-focused profiling of feces is discussed in a companion paper. PMID:27268518

  10. Oil and gas platforms with steam bottoming cycles: System integration and thermoenvironomic evaluation

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter;

    2014-01-01

    The integration of steam bottoming cycles on oil and gas platforms is currently regarded as the most promising option for improving the performance of these energy-intensive systems. In this paper, a North Sea platform is taken as case study, and a systematic analysis of its energy requirements is...... cooling utility, and (iv) the weight limitations on the platform are quantitatively assessed. The results illustrate the benefits of converting the gas turbine process into a combined cycle, since the fuel gas consumption and the total CO2-emissions can be reduced by more than 15 %. Using the cooling...

  11. Framework programmable platform for the advanced software development workstation. Integration mechanism design document

    Science.gov (United States)

    Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Reddy, Uday; Ackley, Keith; Futrell, Mike

    1991-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by this model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated.

  12. An integrated platform for image-guided cardiac resynchronization therapy

    Science.gov (United States)

    Ma, Ying Liang; Shetty, Anoop K.; Duckett, Simon; Etyngier, Patrick; Gijsbers, Geert; Bullens, Roland; Schaeffter, Tobias; Razavi, Reza; Rinaldi, Christopher A.; Rhode, Kawal S.

    2012-05-01

    Cardiac resynchronization therapy (CRT) is an effective procedure for patients with heart failure but 30% of patients do not respond. This may be due to sub-optimal placement of the left ventricular (LV) lead. It is hypothesized that the use of cardiac anatomy, myocardial scar distribution and dyssynchrony information, derived from cardiac magnetic resonance imaging (MRI), may improve outcome by guiding the physician for optimal LV lead positioning. Whole heart MR data can be processed to yield detailed anatomical models including the coronary veins. Cine MR data can be used to measure the motion of the LV to determine which regions are late-activating. Finally, delayed Gadolinium enhancement imaging can be used to detect regions of scarring. This paper presents a complete platform for the guidance of CRT using pre-procedural MR data combined with live x-ray fluoroscopy. The platform was used for 21 patients undergoing CRT in a standard catheterization laboratory. The patients underwent cardiac MRI prior to their procedure. For each patient, a MRI-derived cardiac model, showing the LV lead targets, was registered to x-ray fluoroscopy using multiple views of a catheter looped in the right atrium. Registration was maintained throughout the procedure by a combination of C-arm/x-ray table tracking and respiratory motion compensation. Validation of the registration between the three-dimensional (3D) roadmap and the 2D x-ray images was performed using balloon occlusion coronary venograms. A 2D registration error of 1.2 ± 0.7 mm was achieved. In addition, a novel navigation technique was developed, called Cardiac Unfold, where an entire cardiac chamber is unfolded from 3D to 2D along with all relevant anatomical and functional information and coupled to real-time device detection. This allowed more intuitive navigation as the entire 3D scene was displayed simultaneously on a 2D plot. The accuracy of the unfold navigation was assessed off-line using 13 patient data sets

  13. OpenStudio: An Open Source Integrated Analysis Platform; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Guglielmetti, R.; Macumber, D.; Long, N.

    2011-12-01

    High-performance buildings require an integrated design approach for all systems to work together optimally; systems integration needs to be incorporated in the earliest stages of design for efforts to be cost and energy-use effective. Building designers need a full-featured software framework to support rigorous, multidisciplinary building simulation. An open source framework - the OpenStudio Software Development Kit (SDK) - is being developed to address this need. In this paper, we discuss the needs that drive OpenStudio's system architecture and goals, provide a development status report (the SDK is currently in alpha release), and present a brief case study that illustrates its utility and flexibility.

  14. A chip-scale integrated cavity-electro-optomechanics platform

    CERN Document Server

    Winger, Martin; Alegre, Thiago P Mayer; Safavi-Naeini, Amir H; Meenehan, Seán; Cohen, Justin; Stobbe, Søren; Painter, Oskar

    2011-01-01

    We present an integrated optomechanical and electromechanical nanocavity, in which a common mechanical degree of freedom is coupled to an ultrahigh-Q photonic crystal defect cavity and an electrical circuit. The sys- tem allows for wide-range, fast electrical tuning of the optical nanocavity resonances, and for electrical control of optical radiation pressure back-action effects such as mechanical amplification (phonon lasing), cooling, and stiffening. These sort of integrated devices offer a new means to efficiently interconvert weak microwave and optical signals, and are expected to pave the way for a new class of micro-sensors utilizing optomechanical back-action for thermal noise reduction and low-noise optical read-out.

  15. A chip-scale integrated cavity-electro-optomechanics platform.

    Science.gov (United States)

    Winger, M; Blasius, T D; Mayer Alegre, T P; Safavi-Naeini, A H; Meenehan, S; Cohen, J; Stobbe, S; Painter, O

    2011-12-01

    We present an integrated optomechanical and electromechanical nanocavity, in which a common mechanical degree of freedom is coupled to an ultrahigh-Q photonic crystal defect cavity and an electrical circuit. The system allows for wide-range, fast electrical tuning of the optical nanocavity resonances, and for electrical control of optical radiation pressure back-action effects such as mechanical amplification (phonon lasing), cooling, and stiffening. These sort of integrated devices offer a new means to efficiently interconvert weak microwave and optical signals, and are expected to pave the way for a new class of micro-sensors utilizing optomechanical back-action for thermal noise reduction and low-noise optical read-out. PMID:22273884

  16. ERP Systems - Fully Integrated Solution or a Transactional Platform?

    OpenAIRE

    Sandberg, Johan

    2008-01-01

    This paper addresses the question of how to make use of Enterprise Resource Planning (ERP) systems in companies in the process industry were there is a pervasive need of process standardization. ERP systems have the potential to contribute with standardization and integration of organizational data through an of-the-shelf solution. In practice results of ERP systems implementation has varied greatly. Considering their implications on business processes and the complexity of the systems this s...

  17. TB database: An Integrated Platform for Tuberculosis Research

    OpenAIRE

    Reddy, T. B. K.; Riley, Robert; Wymore, Farrell; Montgomery, Phillip; DeCaprio, Dave; Gellesch, Marcel; Hubble, Jeremy; Jen, Dennis; Jin, Heng; Koehrsen, Michael; Larson, Lisa; Nitzberg, Michael; Sisk, Peter; Stolte, Christian; Weiner, Brian

    2009-01-01

    The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Data...

  18. INsPeCT: INtegrative Platform for Cancer Transcriptomics

    OpenAIRE

    Madhamshettiwar, Piyush B; Maetschke, Stefan R; Davis, Melissa J; Antonio Reverter; Ragan, Mark A

    2014-01-01

    The emergence of transcriptomics, fuelled by high-throughput sequencing technologies, has changed the nature of cancer research and resulted in a massive accumulation of data. Computational analysis, integration, and data visualization are now major bottlenecks in cancer biology and translational research. Although many tools have been brought to bear on these problems, their use remains unnecessarily restricted to computational biologists, as many tools require scripting skills, data infrast...

  19. A chip-scale integrated cavity-electro-optomechanics platform

    DEFF Research Database (Denmark)

    Winger, M.; Blasius, T. D.; Mayer Alegre, T. P.;

    2011-01-01

    resonances, and for electrical control of optical radiation pressure back-action effects such as mechanical amplification (phonon lasing), cooling, and stiffening. These sort of integrated devices offer a new means to efficiently interconvert weak microwave and optical signals, and are expected to pave...... the way for a new class of micro-sensors utilizing optomechanical back-action for thermal noise reduction and low-noise optical read-out....

  20. Thermo-economic assessment of the integration of steam cycles on offshore platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter;

    2014-01-01

    The integration of steam bottoming cycles on oil platforms is often seen as a possible route to mitigate the CO2-emissions offshore. In this paper, a North Sea platform and its energy requirements are systematically analysed. The site-scale integration of steam networks is assessed by using...... thermodynamic and economic performance indicators. The results illustrate the benefits of converting the gas turbines into a combined cycle. Using seawater results in smaller power generation and greater CO2-emissions than using process water, as the additional power generation in the combined cycle is...

  1. Integrated control platform for converged optical and wireless networks

    DEFF Research Database (Denmark)

    Yan, Ying

    . Traffic load and network resources are distributed based on the network states, channel conditions, and QoS requirements. A new aspect in the design of future network is the energy efficiency. An energy management mechanism is proposed and evaluated for the optical network. With regard to power saving, a......The next generation of broadband access networks is expected to be heterogeneous. Multiple wired and wireless systems can be integrated, in order to simultaneously provide seamless access with an appropriate Quality of Service (QoS). Wireless networks support ubiquitous connectivity yet low data...

  2. An integrated photocatalytic microfluidic platform enabling total phosphorus digestion

    International Nuclear Information System (INIS)

    This paper presents an integrated thermally assisted photocatalytic microfluidic chip and its application to the digestion of total phosphorus (TP) in freshwater. A micro heater, a micro temperature sensor, thermal-isolation channels and a polymethylsiloxane (PDMS) reaction chamber were fabricated on the microfluidic chip. Nano-TiO2 film sputtered on the surface of silicon in the reaction area was used as the photocatalyst, and a micro ultraviolet A-ray-light-emitting diode (UVA-LED) array fabricated by MEMS technology were attached to the top of reaction chamber for TP degradation. In this study, sodium tripolyphosphate (Na5P3O10) and sodium glycerophosphate (C3H7Na2O6P) were chosen as the typical components of TP, and these water samples were digested under UVA light irradiation and heating at the same time. Compared with the conventional high-temperature TP digestion which works at 120 °C for 30 min, the thermally assisted UVA digestion method could work at relatively low temperature, and the power consumption is decreased to less than 2 W. Since this digestion method could work without an oxidizing reagent, it is compatible with the electrochemical detection process, which makes it possible to achieve a fully functional detection chip by integrating the digestion unit and electrochemical microelectrode, to realize the on-chip detection of TP, and other water quality parameters such as total nitrogen and chemical oxygen demand. (paper)

  3. Hybrid Integrated Silicon Microfluidic Platform for Fluorescence Based Biodetection

    Directory of Open Access Journals (Sweden)

    André Darveau

    2007-09-01

    Full Text Available The desideratum to develop a fully integrated Lab-on-a-chip device capable ofrapid specimen detection for high throughput in-situ biomedical diagnoses and Point-of-Care testing applications has called for the integration of some of the novel technologiessuch as the microfluidics, microphotonics, immunoproteomics and Micro ElectroMechanical Systems (MEMS. In the present work, a silicon based microfluidic device hasbeen developed for carrying out fluorescence based immunoassay. By hybrid attachment ofthe microfluidic device with a Spectrometer-on-chip, the feasibility of synthesizing anintegrated Lab-on-a-chip type device for fluorescence based biosensing has beendemonstrated. Biodetection using the microfluidic device has been carried out usingantigen sheep IgG and Alexafluor-647 tagged antibody particles and the experimentalresults prove that silicon is a compatible material for the present application given thevarious advantages it offers such as cost-effectiveness, ease of bulk microfabrication,superior surface affinity to biomolecules, ease of disposability of the device etc., and is thussuitable for fabricating Lab-on-a-chip type devices.

  4. OTEC platform configuration and integration. Volume II. Technical concept. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-07-07

    The configuration, integration, and evaluation studies performed in the first phase of this contract resulted in a ranking of the most feasible platform candidates for commercial OTEC applications. On the basis of the results obtained from three individual contractors performing the same study, the Department of Energy made selections of two platform hulls for each contractor for conceptual designs. For Phase-II studies, M. Rosenblatt and Son, Inc. (MR and S) project team was given the SPAR and SPHERE platforms to perform not only conceptual designs for, but also cost and time schedules and sensitivity analyses. This is the second volume of a three-volume MR and S report, and it presents the results of conceptual designs for the two platforms, the facilities and equipment required for construction, deployment, and operation of these platforms, and cost estimates and time schedules. All conceptual design work is performed for the baseline site on West Coast of Florida. The cost differentials and other considerations involved with deploying the platforms in the New Orleans and Puerto Rico sites are also presented. As an end product of the complete study, the costs for the SPAR and the SPHERE platforms are reported both in terms of acquisition costs in 1978 dollars and life cycle costs in dollars per kilowatt.

  5. Agent-Based {\\mu}-Tools Integrated into a Co-Design Platform

    CERN Document Server

    Fougères, Alain-Jérôme

    2012-01-01

    In this paper we present successively the proposition and the design of: 1) {\\mu}-tools adapted to collaborative activity of design, and 2) a multi-agent platform adapted to innovative and distributed design of products or services. This platform called PLACID (innovating and distributed design platform) must support applications of assistance to actors implies in a design process that we have called {\\mu}-tools. {\\mu}-tools are developed with an aim of bringing assistance to Co-design. The use of the paradigm agent as well relates to the modeling and the development of various layers of the platform, that those of the human-computer interfaces. With these objectives, constraints are added to facilitate the integration of new co-operative tools.

  6. Life performance of oil and gas platforms: Site integration and thermodynamic evaluation

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Fülöp, Tamás Gábor; Breuhaus, Peter;

    2014-01-01

    Oil and gas platforms are energy-intensive systems, which operate under changing boundary conditions over time. In this paper, the life performance of an offshore platform is analysed by comparing three representative stages of an oil field (early-life, plateau and end-life productions). The energy...... the exported gas. Multi-objective optimisations are conducted for evaluating the integration of steam and organic Rankine cycles, considering thermodynamic, economic and environmental performance indicators. They indicate that the profitability of a given improvement measure mainly depends on (i) the...... field properties, (ii) the platform operating strategy, and (iii) the production stage of the oil field. The implementation of steam networks appears promising, as it results in a better performance of the offshore platform and in larger economic profits....

  7. OTEC platform configuration and integration study. Volume I. Systems engineering and integration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-04-01

    The economic success of an Ocean Thermal Energy Conversion (OTEC) system is highly dependent on a platform which provides adequate support for the power system, accommodates reliably the cold water pipe, and is most cost effective. The results of a study conducted for the Department of Energy to assess six generic types of platforms to determine the most satisfactory platform for severl potential sites are presented. The six platform configurations are ship, circular barge, semi-submersible, Tuned Sphere, submersible, and spar. These represent directional and symmetric types of platforms which operate on the surface, at the interface, and submerged. The five sites for this study were primarily New Orleans, Keahole Point (Hawaii), Brazil, and secondarily Key West and Puerto Rico. Electrical transmission of energy by submarine cable is the planned form of energy transmission for all sites except Brazil, where chemical conversion is to be the method of transmission. This study is devoted to the platform (or ocean systems) of the OTEC plant which is chiefly comprised of the hull and structure, the seawater system, the position control system, and miscellaneous support/assembly systems. The principal elements in the work breakdown structure for the commercial plants are presented. The assessment of the six platform configurations was conducted utilizing a baseline plan (100-MW(e) (Net)) and site (New Orleans) with variations from the baseline to cover the range of interested platforms and sites.

  8. Integrated silicon photodetector for lab-on-chip sensor platforms

    Science.gov (United States)

    Samusenko, A.; Pucker, G.; Gandolfi, D.; Guider, R.; Ghulinyan, M.; Ficorella, F.; Pavesi, L.

    2015-06-01

    In this paper we demonstrate design, fabrication and characterization of polycrystalline silicon (poly-Si) photodetectors monolithically integrated on top of a silicon oxynitride (SiON) passive photonic circuit. The devices are developed for operation at the wavelength of ~850nm. Interdigitated PIN structures were designed and compared with conventional lateral PIN detectors. The devices, fabricated in standard CMOS technology, exhibit low dark current values of few nanoamperes. The best responsivity of 0.33A/W under a reverse bias of 9V was achieved for lateral PIN detectors with 3-μm interelectrode gap, coupled vertically to the optical waveguide. The applicability of devices for lab-on-chip biosensing has been proved by demonstrating the possibility to reproduce the sensor's spectral response.

  9. Developing a STEP-Compliant Multiagent on an Interoperable and Integrated CAD/CAM Platform

    Directory of Open Access Journals (Sweden)

    Alireza Mokhtar

    2013-01-01

    Full Text Available Practical implementation of a STEP-based architecture to provide a fully integrated and interoperable platform of data exchange has always been an intriguing issue. A variety of CAD/CAM environments are struggling to embed and support STEP standard and its protocols in order to seamlessly operate within global data exchange. However, apparent paucity of efficient and reliable structure for data communication, manipulation, and restoration has remarkably hindered the desired progress. In this paper, taking these shortcomings into account, a practical architecture is introduced and STEP-based agents are implemented and installed on the platform. Moreover, feature recognition, interaction, and machining precedence as crucial issues of CAD/CAM research have been considered in developing the interoperable platform. Seamless integration and interaction of CAD/CAM modules are provided in the proposed system. The prototype is finally verified and discussed through a case study.

  10. GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data

    OpenAIRE

    Rao Kanury; Shapiro Alex; Kumar Dhiraj; Pache Lars; Jäger Stefanie; Mahon Cathal; Bennett Melanie J; Fahey Marie E; Chanda Sumit K; Craik Charles S; Frankel Alan D; Krogan Nevan J

    2011-01-01

    Abstract Background The increasing availability of HIV-host interaction datasets, including both physical and genetic interactions, has created a need for software tools to integrate and visualize the data. Because these host-pathogen interactions are extensive and interactions between human proteins are found within many different databases, it is difficult to generate integrated HIV-human interaction networks. Results We have developed a web-based platform, termed GPS-Prot http://www.gpspro...

  11. U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform

    OpenAIRE

    2014-01-01

    Background In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence-SPECT platform. Next to an optimization in logistics and image fusion, this integration can help improve understanding of the optical imaging (OI) resul...

  12. SITMar Project: an Integrated Platform for Goods Monitoring in Multimodal Transport

    OpenAIRE

    Zappia I.; Cianchi P.; Adembri G.; Gherardelli M.; Giuli D.; Paganelli F.

    2014-01-01

    The SITMar project (Integrated System for Maritime Transport) is an applied research project in the maritime freight providing a set of innovative real-time services for maritime surveillance and goods monitoring. SITMar services are offered on an integrated platform. Specifically, in this paper the system architecture and services for monitoring and tracking of containerized goods during both terrestrial and maritime transport are described. Performance of this system was tested by means of ...

  13. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface

    OpenAIRE

    Sun Yin; Huang Yan; Li Feng; Wang Hong; Fan Cong; Bao Yong; Sun Lu; Ma Zhi; Kong Jun; Li Yu

    2012-01-01

    Abstract Background The virtual screening (VS) of lead compounds using molecular docking and pharmacophore detection is now an important tool in drug discovery. VS tasks typically require a combination of several software tools and a molecular graphics system. Thus, the integration of all the requisite tools in a single operating environment could reduce the complexity of running VS experiments. However, only a few freely available integrated software platforms have been developed. Results A ...

  14. Integrated nanophotonic frequency shifter on the silicon-organic hybrid (SOH) platform for laser vibrometry

    International Nuclear Information System (INIS)

    We demonstrate a waveguide-based frequency shifter on the silicon photonic platform, enabling frequency shifts up to 10 GHz. The device is realized by silicon-organic hybrid (SOH) integration. Temporal shaping of the drive signal allows the suppression of spurious side-modes by more than 23 dB

  15. Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human-Activity Monitoringand Personal Healthcare.

    Science.gov (United States)

    Trung, Tran Quang; Lee, Nae-Eung

    2016-06-01

    Flexible and stretchable physical sensors that can measure and quantify electrical signals generated by human activities are attracting a great deal of attention as they have unique characteristics, such as ultrathinness, low modulus, light weight, high flexibility, and stretchability. These flexible and stretchable physical sensors conformally attached on the surface of organs or skin can provide a new opportunity for human-activity monitoring and personal healthcare. Consequently, in recent years there has been considerable research effort devoted to the development of flexible and stretchable physical sensors to fulfill the requirements of future technology, and much progress has been achieved. Here, the most recent developments of flexible and stretchable physical sensors are described, including temperature, pressure, and strain sensors, and flexible and stretchable sensor-integrated platforms. The latest successful examples of flexible and stretchable physical sensors for the detection of temperature, pressure, and strain, as well as their novel structures, technological innovations, and challenges, are reviewed first. In the next section, recent progress regarding sensor-integrated wearable platforms is overviewed in detail. Some of the latest achievements regarding self-powered sensor-integrated wearable platform technologies are also reviewed. Further research direction and challenges are also proposed to develop a fully sensor-integrated wearable platform for monitoring human activity and personal healthcare in the near future. PMID:26840387

  16. Multi-fields' coordination information integrated platform for nuclear power plant operation preparation

    International Nuclear Information System (INIS)

    To realize the coordination in multi-fields' work and information sharing, by applying the method of Enterprise Architecture (EA), the business architecture, functional flow and application architecture of Nuclear Power Plant's operation preparation information integrated platform are designed, which can realize the information sharing and coordination of multi fields. (authors)

  17. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface

    Directory of Open Access Journals (Sweden)

    Sun Yin

    2012-01-01

    Full Text Available Abstract Background The virtual screening (VS of lead compounds using molecular docking and pharmacophore detection is now an important tool in drug discovery. VS tasks typically require a combination of several software tools and a molecular graphics system. Thus, the integration of all the requisite tools in a single operating environment could reduce the complexity of running VS experiments. However, only a few freely available integrated software platforms have been developed. Results A free open-source platform, IVSPlat 1.0, was developed in this study for the management and automation of VS tasks. We integrated several VS-related programs into a molecular graphics system to provide a comprehensive platform for the solution of VS tasks based on molecular docking, pharmacophore detection, and a combination of both methods. This tool can be used to visualize intermediate and final results of the VS execution, while also providing a clustering tool for the analysis of VS results. A case study was conducted to demonstrate the applicability of this platform. Conclusions IVSPlat 1.0 provides a plug-in-based solution for the management, automation, and visualization of VS tasks. IVSPlat 1.0 is an open framework that allows the integration of extra software to extend its functionality and modified versions can be freely distributed. The open source code and documentation are available at http://kyc.nenu.edu.cn/IVSPlat/.

  18. SysBioCube: A Data Warehouse and Integrative Data Analysis Platform Facilitating Systems Biology Studies of Disorders of Military Relevance.

    Science.gov (United States)

    Chowbina, Sudhir; Hammamieh, Rasha; Kumar, Raina; Chakraborty, Nabarun; Yang, Ruoting; Mudunuri, Uma; Jett, Marti; Palma, Joseph M; Stephens, Robert

    2013-01-01

    SysBioCube is an integrated data warehouse and analysis platform for experimental data relating to diseases of military relevance developed for the US Army Medical Research and Materiel Command Systems Biology Enterprise (SBE). It brings together, under a single database environment, pathophysio-, psychological, molecular and biochemical data from mouse models of post-traumatic stress disorder and (pre-) clinical data from human PTSD patients.. SysBioCube will organize, centralize and normalize this data and provide an access portal for subsequent analysis to the SBE. It provides new or expanded browsing, querying and visualization to provide better understanding of the systems biology of PTSD, all brought about through the integrated environment. We employ Oracle database technology to store the data using an integrated hierarchical database schema design. The web interface provides researchers with systematic information and option to interrogate the profiles of pan-omics component across different data types, experimental designs and other covariates. PMID:24303294

  19. COMMON FRAMEWORK: A HYBRID APPROACH TO INTEGRATE CROSS-PLATFORM COMPONENTS IN MOBILE APPLICATION

    Directory of Open Access Journals (Sweden)

    Joachim Perchat

    2014-01-01

    Full Text Available There is a multitude of mobile OS: iOS android, Windows Phone 8 and each OS provides its own standards and tools. This heterogeneity in the mobile domain forces developers to implement an application for each mobile platform. To achieve that, developers need to master several languages (Java, Objective-C.... They also need to have several devices at their disposal (PC, Mac, many smartphones .... Then, after applications distributions, developers have to maintain several source codes. In this study, we tackle this problematic. Our goal is to soften the differences between each OS in order to simplify the development of cross-platform third-party applications. To achieve that, we have defined a framework called COMMON (Component Oriented programming for Mobile Multi OsiNtegration. This framework allows the integration of cross-platform components in any application (iOS android. To run our components on any OS, we provide an implementation for each platform. However, to make their integrations easier, we also provide a common public interface of each component, which is platform-independent. Besides, we provide a common language, also platform-independent, allowing the integration and use of any component in any native application (iOS android. This language is based on annotations. Finally, we have implemented a cross-compiler, which translates the source code written with our language to native source code: Objective-C for iOS, Java for Android,... In this study, we have shown that our solution offers performance and memory consumption closed to native applications. Finally, with COMMON, mobile developers implement less lines of source code than with a native application. In your test application, we have saved 30%.

  20. An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes

    Science.gov (United States)

    Guldner, Ian H.; Yang, Lin; Cowdrick, Kyle R.; Wang, Qingfei; Alvarez Barrios, Wendy V.; Zellmer, Victoria R.; Zhang, Yizhe; Host, Misha; Liu, Fang; Chen, Danny Z.; Zhang, Siyuan

    2016-04-01

    Metastatic microenvironments are spatially and compositionally heterogeneous. This seemingly stochastic heterogeneity provides researchers great challenges in elucidating factors that determine metastatic outgrowth. Herein, we develop and implement an integrative platform that will enable researchers to obtain novel insights from intricate metastatic landscapes. Our two-segment platform begins with whole tissue clearing, staining, and imaging to globally delineate metastatic landscape heterogeneity with spatial and molecular resolution. The second segment of our platform applies our custom-developed SMART 3D (Spatial filtering-based background removal and Multi-chAnnel forest classifiers-based 3D ReconsTruction), a multi-faceted image analysis pipeline, permitting quantitative interrogation of functional implications of heterogeneous metastatic landscape constituents, from subcellular features to multicellular structures, within our large three-dimensional (3D) image datasets. Coupling whole tissue imaging of brain metastasis animal models with SMART 3D, we demonstrate the capability of our integrative pipeline to reveal and quantify volumetric and spatial aspects of brain metastasis landscapes, including diverse tumor morphology, heterogeneous proliferative indices, metastasis-associated astrogliosis, and vasculature spatial distribution. Collectively, our study demonstrates the utility of our novel integrative platform to reveal and quantify the global spatial and volumetric characteristics of the 3D metastatic landscape with unparalleled accuracy, opening new opportunities for unbiased investigation of novel biological phenomena in situ.

  1. Life performance of oil and gas platforms: Site integration and thermodynamic evaluation

    International Nuclear Information System (INIS)

    Oil and gas platforms are energy-intensive systems, which operate under changing boundary conditions over time. In this paper, the life performance of an offshore platform is analysed by comparing three representative stages of an oil field (early-life, plateau and end-life productions). The energy requirements are assessed by a process integration study, and the system inefficiencies are pinpointed by performing an exergy accounting. The heating and cooling requirements vary significantly over time, and most inefficiencies take place in processes where chemical exergy is consumed (≃50–55%), thermal exergy is transferred (≃15–20%), or mechanical exergy is varied (≃0–15%). These findings are valid for all production periods: this suggests that more attention should be paid on a proper integration of the processing and utility plants, by, for instance, recovering heat from the turbine exhausts and from the exported gas. Multi-objective optimisations are conducted for evaluating the integration of steam and organic Rankine cycles, considering thermodynamic, economic and environmental performance indicators. They indicate that the profitability of a given improvement measure mainly depends on (i) the field properties, (ii) the platform operating strategy, and (iii) the production stage of the oil field. The implementation of steam networks appears promising, as it results in a better performance of the offshore platform and in larger economic profits. - Highlights: • The lifetime performance of an existing oil and gas platform is assessed. • Total site and exergy analyses are performed to pinpoint the plant inefficiencies. • The integration of steam networks and low-temperature cycles is investigated

  2. Heterogeneously integrated optical detection platform for on-chip sensing applications

    Science.gov (United States)

    Chaudhuri, Ritesh Ray; Song, Youngsik; Seo, Sang-Woo

    2015-10-01

    This paper introduces a resonant waveguide grating (RWG) integrated with a photodetector for on-chip sensing applications. An inverted thin film indium gallium arsenide (InGaAs) metal-semiconductor-metal photodetector is heterogeneously integrated on silicon dioxide (SiO2)/ silicon substrate using fluidic self-assembly. The inverted optical waveguide and the RWG structure are subsequently fabricated utilizing layer-by-layer post-processing techniques. Detailed electrical, optical, and optoelectronic characterization were performed to analyze the functionality of the sensing platform. This approach can open new avenues allowing the development of low-cost complementary metal-oxide semiconductor compatible integrated optical sensors.

  3. Nucleic Acid-based Detection of Bacterial Pathogens Using Integrated Microfluidic Platform Systems

    Directory of Open Access Journals (Sweden)

    Carl A. Batt

    2009-05-01

    Full Text Available The advent of nucleic acid-based pathogen detection methods offers increased sensitivity and specificity over traditional microbiological techniques, driving the development of portable, integrated biosensors. The miniaturization and automation of integrated detection systems presents a significant advantage for rapid, portable field-based testing. In this review, we highlight current developments and directions in nucleic acid-based micro total analysis systems for the detection of bacterial pathogens. Recent progress in the miniaturization of microfluidic processing steps for cell capture, DNA extraction and purification, polymerase chain reaction, and product detection are detailed. Discussions include strategies and challenges for implementation of an integrated portable platform.

  4. Integrated Tourism E-Commerce Platform for Scenery Administration Bureau, Travel Agency and Tourist

    Science.gov (United States)

    Liang, Zhixue; Wang, Shui

    Collaboration among multiple travel agencies and with scenery administration bureaus is vital for small or medium sized travel companies to succeed in the fierce competition of the tourism industry; business processes such as regrouping individual travelers between different agencies prove to be difficult and unpleasant user experience; tourists want to be more informed and have more initiative. To address these issues, proposes an integrated tourism e-commerce platform for travel agencies and scenery administration bureaus as well as tourists to interact in a more smooth way; this platform is constructed upon J2EE framework, provides online collaboration & coordination for companies and information services (such as self-navigation using Google Map etc) for tourists. A running implementation of this platform has been put into real business for a small travel company.

  5. Technology assessment for an integrated PC-based platform for three telemedicine applications

    Science.gov (United States)

    Tohme, Walid G.; Hayes, Wendelin S.; Dai, Hailei L.; Komo, Darmadi; Pahira, John J.; Abernethy, Darrell R.; Rennert, Wolfgang; Kuehl, Karen S.; Hauser, Gabriel J.; Mun, Seong K.

    1996-05-01

    This paper investigates the design and technical efficacy of an integrated PC based platform for three different medical applications. The technical efficacy of such a telemedicine platform has not been evaluated in the literature and optimal technical requirements have not been developed. The first application, with the Department of Surgery, Division of Urology, tests the utility of a telemedicine platform including radiology images for a surgical stone disease consultation service from an off site location in West Virginia. The second application, with the Department of Internal Medicine, Division of Clinical Pharmacology, investigates the usefulness of telemedicine when used for a clinical pharmacology consultation service from an off-site location. The third application, with the Department of Pediatrics, will test telemedicine for trauma care triage service first within an off-site location in Virginia and then from there to Georgetown University Medical Center.

  6. GPS-Prot: A web-based visualization platform for integrating host-pathogen interaction data

    Directory of Open Access Journals (Sweden)

    Rao Kanury

    2011-07-01

    Full Text Available Abstract Background The increasing availability of HIV-host interaction datasets, including both physical and genetic interactions, has created a need for software tools to integrate and visualize the data. Because these host-pathogen interactions are extensive and interactions between human proteins are found within many different databases, it is difficult to generate integrated HIV-human interaction networks. Results We have developed a web-based platform, termed GPS-Prot http://www.gpsprot.org, that allows for facile integration of different HIV interaction data types as well as inclusion of interactions between human proteins derived from publicly-available databases, including MINT, BioGRID and HPRD. The software has the ability to group proteins into functional modules or protein complexes, generating more intuitive network representations and also allows for the uploading of user-generated data. Conclusions GPS-Prot is a software tool that allows users to easily create comprehensive and integrated HIV-host networks. A major advantage of this platform compared to other visualization tools is its web-based format, which requires no software installation or data downloads. GPS-Prot allows novice users to quickly generate networks that combine both genetic and protein-protein interactions between HIV and its human host into a single representation. Ultimately, the platform is extendable to other host-pathogen systems.

  7. Passive active resonant coupler (PARC): A new platform for monolithic integration of photonic devices

    Science.gov (United States)

    Saini, Simarjeet

    The explosive growth of telecommunications and data traffic in recent years has hastened the emergence of optical communication networks. As the volume and complexity of network traffic increases, efficient methods are required for routing and distributing the associated optical signals. This in turn has put pressure on optical device technologies. Not only are new and more complex devices required, but they must also be manufactured and packaged in a cost-efficient way. Soon, there will be a shift in the paradigm from using discrete packaged devices in a module to monolithically integrated photonic circuits where multiple functions are achieved in a single chip. This offers a considerable challenge and a great opportunity for device engineers. It is the goal of this work to continue and expand the sphere of knowledge and applicability of Photonic Integrated circuits (PIC's) by proposing and demonstrating a new platform technology for monolithically integrating various active and passive optical devices. The platform, which has been named the ``Passive Active Resonant Coupler (PARC)'', utilizes single epitaxial growth and conventional fabrication schemes. PARC devices rely on coupling between vertical waveguides where each waveguide is optimized for its specific functionality. The coupling is achieved by using a new proposed scheme of resonance over some specially designed tapers. It has been shown experimentally for the first time that very high coupling efficiencies (less than 1 dB loss) can be achieved over very short lengths, typically less than 100 μm. Coupling between different kinds of active and passive waveguides has been experimentally demonstrated. A few basic PIC's such as the 1 × 2 optical switch and the 2 × 2 cross-point switch have been demonstrated by integrating active and passive waveguides using the PARC platform. The demonstrated integration work is in the 1.55 μm wavelength range using InP as a substrate. However, the PARC platform is

  8. Integrated method to optimize well connection and platform placement on a multi-reservoir scenario

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, Sergio Henrique Guerra de; Madeira, Marcelo Gomes; Franca, Martha Salles [Halliburton, Rio de Janeiro, RJ (Brazil); Mota, Rosane Oliveira; Silva, Edilon Ribeiro da; King, Vanessa Pereira Spear [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    This paper describes a workflow created to optimize the platform placement and well-platform connections on a multi reservoir scenario using an integrated reservoir simulator paired with an optimization engine. The proposed methodology describes how a new platform, being incorporated into a pre-existing asset, can be better used to develop newly-discovered fields, while helping increase the production of existing fields by sharing their production load. The sharing of production facilities is highly important in Brazilian offshore assets because of their high price (a few billion dollars per facility) and the fact that total production is usually limited to the installed capacity of liquid processing, which is an important constraint on high water-cut well production rates typical to this region. The case study asset used to present the workflow consists of two deep water oil fields, each one developed by its own production platform, and a newly-discovered field with strong aquifer support that will be entirely developed with a new production platform. Because this new field should not include injector wells owing to the strong aquifer presence, the idea is to consider reconnecting existing wells from the two pre-existing fields to better use the production resources. In this scenario, the platform location is an important optimization issue, as a balance between supporting the production of the planned wells on the new field and the production of re-routed wells from the existing fields must be reached to achieve improved overall asset production. If the new platform is too far away from any interconnected production well, pressure-drop issues along the pipeline might actually decrease production from the existing fields rather than augment it. The main contribution of this work is giving the reader insights on how to model and optimize these complex decisions to generate high-quality scenarios. (author)

  9. The business impact of an integrated continuous biomanufacturing platform for recombinant protein production.

    Science.gov (United States)

    Walther, Jason; Godawat, Rahul; Hwang, Chris; Abe, Yuki; Sinclair, Andrew; Konstantinov, Konstantin

    2015-11-10

    The biotechnology industry primarily uses batch technologies to manufacture recombinant proteins. The natural evolution of other industries has shown that transitioning from batch to continuous processing can yield significant benefits. A quantitative understanding of these benefits is critical to guide the implementation of continuous processing. In this manuscript, we use process economic modeling and Monte Carlo simulations to evaluate an integrated continuous biomanufacturing (ICB) platform and conduct risk-based valuation to generate a probabilistic range of net-present values (NPVs). For a specific ten-year product portfolio, the ICB platform reduces average cost by 55% compared to conventional batch processing, considering both capital and operating expenses. The model predicts that these savings can further increase by an additional 25% in situations with higher-than-expected product demand showing the upward potential of the ICB platform. The ICB platform achieves these savings and corresponding flexibility mainly due to process intensification in both upstream and downstream unit operations. This study demonstrates the promise of continuous bioprocessing while also establishing a novel framework to quantify financial benefits of other platform process technologies. PMID:26014522

  10. Design and Analysis of a Compact Precision Positioning Platform Integrating Strain Gauges and the Piezoactuator

    Directory of Open Access Journals (Sweden)

    Shunguang Wan

    2012-07-01

    Full Text Available Miniaturization precision positioning platforms are needed for in situ nanomechanical test applications. This paper proposes a compact precision positioning platform integrating strain gauges and the piezoactuator. Effects of geometric parameters of two parallel plates on Von Mises stress distribution as well as static and dynamic characteristics of the platform were studied by the finite element method. Results of the calibration experiment indicate that the strain gauge sensor has good linearity and its sensitivity is about 0.0468 mV/μm. A closed-loop control system was established to solve the problem of nonlinearity of the platform. Experimental results demonstrate that for the displacement control process, both the displacement increasing portion and the decreasing portion have good linearity, verifying that the control system is available. The developed platform has a compact structure but can realize displacement measurement with the embedded strain gauges, which is useful for the closed-loop control and structure miniaturization of piezo devices. It has potential applications in nanoindentation and nanoscratch tests, especially in the field of in situ nanomechanical testing which requires compact structures.

  11. Oil and gas platforms with steam bottoming cycles: System integration and thermoenvironomic evaluation

    International Nuclear Information System (INIS)

    Highlights: • The energy demand of a North Sea platform is systematically analysed. • The integration of steam bottoming cycles is investigated, considering energy, economic and environmental criteria. • The fuel gas consumption and total CO2-emissions can be reduced by more than 15%. - Abstract: The integration of steam bottoming cycles on oil and gas platforms is currently regarded as the most promising option for improving the performance of these energy-intensive systems. In this paper, a North Sea platform is taken as case study, and a systematic analysis of its energy requirements is conducted. The site-scale integration of steam networks is evaluated, based on thermodynamic, economic and environmental performance indicators. The penalties induced by operational restrictions such as (i) the use of a heat transfer loop, (ii) the demand for a heat buffer, (iii) the selection of a specific cooling utility, and (iv) the weight limitations on the platform are quantitatively assessed. The results illustrate the benefits of converting the gas turbine process into a combined cycle, since the fuel gas consumption and the total CO2-emissions can be reduced by more than 15%. Using the cooling water from the processing plant reveals to be more profitable than using seawater, as the additional pumping power outweighs the benefit of using a cooling medium at a temperature of about 8 °C lower. This study highlights thereby the importance of analysing energy savings and recovery options at the scale of the entire platform, rather than at the level of the utility plant solely

  12. A generalized CMOS-MEMS platform for micromechanical resonators monolithically integrated with circuits

    International Nuclear Information System (INIS)

    A generalized foundry-oriented CMOS-MEMS platform well suited for integrated micromechanical resonators alongside IC amplifiers has been developed for commercial multi-user purpose and demonstrated with a fast turnaround time of only 3 months and a variety of design flexibilities for resonator applications. With this platform, different configurations of capacitively-transduced resonators monolithically integrated with their amplifier circuits, spanning frequencies from 500 kHz to 14.5 MHz, have been realized with resonator Q's ranging between 700 and 3500. This platform, specifically featured with various configurations of structural materials, multi-dimensional displacements, different arrangements of mechanical boundary conditions, tiny supports of resonators, large transduction areas, well-defined anchors and performance enhancement scaling with IC fabrication technology, offers a variety of flexible design options targeted for sensor, timing reference, and RF applications. In addition, resonators consisting of metal-oxide composite structures fabricated by this platform offer an effective temperature compensation scheme for the first time in CMOS-MEMS resonators, showing TCf six times better than that of resonators merely made by CMOS metals

  13. Media integration platform on superhigh-definition images: parallel digital signal processor approach

    Science.gov (United States)

    Ono, Sadayasu; Ohta, Naohisa; Fujii, Tetsuro

    1993-11-01

    This paper presents a new media integration platform based on super high definition (SHD) digital images and a high performance image processing system that adopts parallel digital processing. The new platform will encourage the integration of all existing media to realize rich and realistic visual communication over B-ISDN. SHD images have a resolution of more than 2048 X 2048 pixels and the frame rate is more than 60 frames/sec. To achieve the real-time compression of SHD moving images, parallel signal processing systems with a peak performance of 0.5 Tera Flops will be necessary. The specification requirements, focusing on the digital signal processing systems needed to achieve SHD image communication, are discussed.

  14. Unified Electronic Currency Based on the Fourth Party Platform Integrated Payment Service

    Science.gov (United States)

    Yong, Xu; Qiqi, Hu

    This paper presents a solution of unified e-currency based on the fourth party platform integrated payment service. The purpose of the paper is to solve the problem of distribution and resource-wasting caused by the lack of unified electronic currency, and to solve regulatory difficulties due to regulation size caused by a wide variety of e-currency. Methods: This article first analyzes the problems in the development of electronic money, and then proposes the concept of a unified electronic currency based on the fourth party platform integrated payment service. Besides, it proposes a unified mechanism and transaction procedures for unified e-currency, and analyzes the liquidation process, security and regulatory requirements, which are involved in using unified electronic currency.

  15. AN ENHANCED REMOTE AUTHENTICATION SCHEME USING SECURE KEY EXCHANGE PROTOCOL WITH PLATFORM INTEGRITY ATTESTATION

    Directory of Open Access Journals (Sweden)

    Fazli Bin Mat Nor

    2011-01-01

    Full Text Available Most remote authentication schemes use key exchange protocol to provide secure communication over an untrusted network. The protocol enables remote client and host to authenticate each other and communicate securely with prearranged shared secret key or server secret key. Many remote services environment such as online banking and electronic commerce are dependent on remote authentication schemes to validate user legitimacy in order to fulfill the authentication process. Unfortunately, these schemes are not able to provide trust or evidence of claimed platform identity. Therefore, these schemes are vulnerable to malicious software attacks that could compromise the integrity of the platform used for the communication. As a result, user identity or shared secret key potentially can be exposed. In this paper, we present a remote authentication scheme using secure key exchange protocol with hardware based attestation to resist malicious software attack. In addition, a pseudonym identity enhancement is integrated into the scheme in order to improve user identity privacy.

  16. Integrative modeling of multi-platform genomic data under the framework of mediation analysis

    OpenAIRE

    Huang, Yen-Tsung

    2014-01-01

    Given the availability of genomic data, there have been emerging interests in integrating multi-platform data. Here, we propose to model genetics (single nucleotide polymorphism (SNP)), epigenetics (DNA methylation), and gene expression data as a biological process to delineate phenotypic traits under the framework of causal mediation modeling. We propose a regression model for the joint effect of SNPs, methylation, gene expression, and their nonlinear interactions on the outcome and develop ...

  17. seqMINER: an integrated ChIP-seq data interpretation platform

    OpenAIRE

    Ye, T; Krebs, A. R.; Choukrallah, M.-A.; Keime, C.; Plewniak, F.; Davidson, I; Tora, L

    2011-01-01

    In a single experiment, chromatin immunoprecipitation combined with high throughput sequencing (ChIP-seq) provides genome-wide information about a given covalent histone modification or transcription factor occupancy. However, time efficient bioinformatics resources for extracting biological meaning out of these gigabyte-scale datasets are often a limiting factor for data interpretation by biologists. We created an integrated portable ChIP-seq data interpretation platform called seqMINER, wit...

  18. An Integrated Platform Supporting Intangible Cultural Heritage Learning and Transmission: Definition of Requirements and Evaluation Criteria

    OpenAIRE

    Dagnino, Francesca M.; Hadjileontiadis, Leontios J.; Ott, Michela; Pozzi, Francesca

    2014-01-01

    The paper offers an experience-based viewpoint on two key phases of the development of an Information and Communication Technologies (ICTs)-based system: the definition of requirements and identification of related criteria and methodology for its evaluation. In doing so, it refers to the unique context of the i-Treasures EU project, which deals with the development of an innovative integrated platform to support the learning and transmission of Intangible Cultural Heritage (ICH). The i-Treas...

  19. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

    OpenAIRE

    Hosoya, Hitomi; Andrey S Dobroff; Driessen, Wouter H. P.; Cristini, Vittorio; Brinker, Lina M.; Staquicini, Fernanda I.; Cardó-Vila, Marina; D’Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; Lin, Yu-Shen; Dunphy, Darren R.; Dogra, Prashant; Melancon, Marites P.; Stafford, R. Jason

    2016-01-01

    The main goal in the emerging field of cancer nanomedicine is to generate, standardize, and produce multifunctional carriers designed to improve the response of drugs against tumors. Here we report the design, development, and preclinical validation of a ligand-directed bioinorganic platform that integrates tumor targeting, receptor-mediated cell internalization, photon-to-heat conversion, and drug delivery. This enabling hydrogel-based technology can accommodate a broad variety of ligands, n...

  20. An integrated telemedicine platform for the assessment of affective physiological states

    OpenAIRE

    Ganiatsas George; Katsis Christos D; Fotiadis Dimitrios I

    2006-01-01

    Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a) a multisensorial wearable, (b) a data acquisition and wireless communication module, (c) a feature extraction module, (d) a 3D facial animation module which is used for the projectio...

  1. Portable integrated micro-fluidic platform for the monitoring and detection of nitrite

    OpenAIRE

    Czugala, Monika; Fay, Cormac; O'Connor, Noel E.; Corcoran, Brian; Benito-Lopez, Fernando; Diamond, Dermot

    2013-01-01

    A wireless, portable integrated micro-fluidic platform is proposed and applied for the determination of nitrite anions in water. The colourimetric analysis of nitrite is based on the Griess reagent, and the colour intensity of nitrite Griess reagent complex is detected using a low cost Paired Emitter Detector Diode technique. The micro-fluidic device employed a photoswitchable micro-valve, controlled by white light and generated using a light emitting diode. This low-cost and low-power detect...

  2. Developing a STEP-Compliant Multiagent on an Interoperable and Integrated CAD/CAM Platform

    OpenAIRE

    Alireza Mokhtar; Omid Fatahi Valilai

    2013-01-01

    Practical implementation of a STEP-based architecture to provide a fully integrated and interoperable platform of data exchange has always been an intriguing issue. A variety of CAD/CAM environments are struggling to embed and support STEP standard and its protocols in order to seamlessly operate within global data exchange. However, apparent paucity of efficient and reliable structure for data communication, manipulation, and restoration has remarkably hindered the desired progress. In this ...

  3. An Integrated System for Disabled People Developed with the Agent Platform PANGEA

    Directory of Open Access Journals (Sweden)

    Carolina ZATO

    2013-11-01

    Full Text Available New trends in multi-agent systems call for self-adaptation and high dynamics, hence the new model of open MAS or virtual organization of agents. However, as existing agent platforms are not yet equipped to support this behavior, it is necessary to create new systems and mechanisms to facilitate the development of these new architectures. This article presents PANGEA, an agent platform to develop open multi-agent systems, specifically those including organizational aspects such as virtual agent organizations. The platform allows the integral management of organizations and offers tools to the end user. Additionally, it includes a communication protocol based on the IRC standard, which facilitates implementation and remains robust even with a large number of connections. The introduction of a CommunicationAgent and a Sniffer make it possible to offer Web Services for the distributed control of interaction. In order to test PANGEA, an integral system was developed to help the disabled, gathering a set of easily deployable and integrated services under a single architecture.

  4. The Role of Semantics in Open-World, Integrative, Collaborative Science Data Platforms

    Science.gov (United States)

    Fox, Peter; Chen, Yanning; Wang, Han; West, Patrick; Erickson, John; Ma, Marshall

    2014-05-01

    As collaborative science spreads into more and more Earth and space science fields, both participants and funders are expressing stronger needs for highly functional data and information capabilities. Characteristics include a) easy to use, b) highly integrated, c) leverage investments, d) accommodate rapid technical change, and e) do not incur undue expense or time to build or maintain - these are not a small set of requirements. Based on our accumulated experience over the last ~ decade and several key technical approaches, we adapt, extend, and integrate several open source applications and frameworks to handle major portions of functionality for these platforms. This includes: an object-type repository, collaboration tools, identity management, all within a portal managing diverse content and applications. In this contribution, we present our methods and results of information models, adaptation, integration and evolution of a networked data science architecture based on several open source technologies (Drupal, VIVO, the Comprehensive Knowledge Archive Network; CKAN, and the Global Handle System; GHS). In particular we present the Deep Carbon Observatory - a platform for international science collaboration. We present and discuss key functional and non-functional attributes, and discuss the general applicability of the platform.

  5. Solution to the problem of the close integration of satellite and inertial platform navigation systems

    Science.gov (United States)

    Pogorelov, V. A.; Sokolov, S. V.

    2015-11-01

    The problem of the close integration of a satellite and inertial navigation system (NA) constructed on the basis of a gyro-stabilized platform is solved. The features of the synthesis of an algorithm for nonlinear estimation of the NS state vector in view of the continuous character for the autonomous measurements and the discrete character for satellite measurements are studied. The developed algorithm for solving the navigation problem on the basis of the integrated NS allows one to provide a stable high-precision estimation of the parameters of motion for a movable object, including in the absence of satellite signals.

  6. Design of A Development Platform for HW/SW Codesign ofWireless Integrated Sensor Nodes

    DEFF Research Database (Denmark)

    Virk, Kashif; Madsen, Jan; Lorentzen, Andreas;

    2005-01-01

    parameters which is only possible by making system-level design decisions about its hardware and software (operating system and applications) architecture. In this paper, we present the design of a sensor node development platform in relation to an application of wireless integrated sensor networks for sow......Wireless integrated sensor networks are a new class of embedded computer systems which have been made possible mainly by the recent advances in the micro and the nano technology. In order to efficiently utilize the limited resources available on a sensor node, we need to optimize its key design...

  7. SERVIR-Africa: Developing an Integrated Platform for Floods Disaster Management in Africa

    Science.gov (United States)

    Macharia, Daniel; Korme, Tesfaye; Policelli, Fritz; Irwin, Dan; Adler, Bob; Hong, Yang

    2010-01-01

    SERVIR-Africa is an ambitious regional visualization and monitoring system that integrates remotely sensed data with predictive models and field-based data to monitor ecological processes and respond to natural disasters. It aims addressing societal benefits including floods and turning data into actionable information for decision-makers. Floods are exogenous disasters that affect many parts of Africa, probably second only to drought in terms of social-economic losses. This paper looks at SERVIR-Africa's approach to floods disaster management through establishment of an integrated platform, floods prediction models, post-event flood mapping and monitoring as well as flood maps dissemination in support of flood disaster management.

  8. Insight: An ontology-based integrated database and analysis platform for epilepsy self-management research.

    Science.gov (United States)

    Sahoo, Satya S; Ramesh, Priya; Welter, Elisabeth; Bukach, Ashley; Valdez, Joshua; Tatsuoka, Curtis; Bamps, Yvan; Stoll, Shelley; Jobst, Barbara C; Sajatovic, Martha

    2016-10-01

    We present Insight as an integrated database and analysis platform for epilepsy self-management research as part of the national Managing Epilepsy Well Network. Insight is the only available informatics platform for accessing and analyzing integrated data from multiple epilepsy self-management research studies with several new data management features and user-friendly functionalities. The features of Insight include, (1) use of Common Data Elements defined by members of the research community and an epilepsy domain ontology for data integration and querying, (2) visualization tools to support real time exploration of data distribution across research studies, and (3) an interactive visual query interface for provenance-enabled research cohort identification. The Insight platform contains data from five completed epilepsy self-management research studies covering various categories of data, including depression, quality of life, seizure frequency, and socioeconomic information. The data represents over 400 participants with 7552 data points. The Insight data exploration and cohort identification query interface has been developed using Ruby on Rails Web technology and open source Web Ontology Language Application Programming Interface to support ontology-based reasoning. We have developed an efficient ontology management module that automatically updates the ontology mappings each time a new version of the Epilepsy and Seizure Ontology is released. The Insight platform features a Role-based Access Control module to authenticate and effectively manage user access to different research studies. User access to Insight is managed by the Managing Epilepsy Well Network database steering committee consisting of representatives of all current collaborating centers of the Managing Epilepsy Well Network. New research studies are being continuously added to the Insight database and the size as well as the unique coverage of the dataset allows investigators to conduct

  9. Integrative Data Analysis of Multi-Platform Cancer Data with a Multimodal Deep Learning Approach.

    Science.gov (United States)

    Liang, Muxuan; Li, Zhizhong; Chen, Ting; Zeng, Jianyang

    2015-01-01

    Identification of cancer subtypes plays an important role in revealing useful insights into disease pathogenesis and advancing personalized therapy. The recent development of high-throughput sequencing technologies has enabled the rapid collection of multi-platform genomic data (e.g., gene expression, miRNA expression, and DNA methylation) for the same set of tumor samples. Although numerous integrative clustering approaches have been developed to analyze cancer data, few of them are particularly designed to exploit both deep intrinsic statistical properties of each input modality and complex cross-modality correlations among multi-platform input data. In this paper, we propose a new machine learning model, called multimodal deep belief network (DBN), to cluster cancer patients from multi-platform observation data. In our integrative clustering framework, relationships among inherent features of each single modality are first encoded into multiple layers of hidden variables, and then a joint latent model is employed to fuse common features derived from multiple input modalities. A practical learning algorithm, called contrastive divergence (CD), is applied to infer the parameters of our multimodal DBN model in an unsupervised manner. Tests on two available cancer datasets show that our integrative data analysis approach can effectively extract a unified representation of latent features to capture both intra- and cross-modality correlations, and identify meaningful disease subtypes from multi-platform cancer data. In addition, our approach can identify key genes and miRNAs that may play distinct roles in the pathogenesis of different cancer subtypes. Among those key miRNAs, we found that the expression level of miR-29a is highly correlated with survival time in ovarian cancer patients. These results indicate that our multimodal DBN based data analysis approach may have practical applications in cancer pathogenesis studies and provide useful guidelines for

  10. A platform for analysis of nanoscale liquids with an integrated sensor array based on 2-d material

    CERN Document Server

    Engel, M; Neumann, R F; Giro, R; Feger, C; Avouris, P; Steiner, M

    2016-01-01

    Analysis of nanoscale liquids, including wetting and flow phenomena, is a scientific challenge with far reaching implications for industrial technologies. We report the conception, development, and application of an integrated platform for the experimental characterization of liquids at the nanometer scale. The platform combines the sensing functionalities of an integrated, two-dimensional electronic device array with in situ application of highly sensitive optical micro-spectroscopy and atomic force microscopy. We demonstrate the performance capabilities of the platform with an embodiment based on an array of integrated, optically transparent graphene sensors. The application of electronic and optical sensing in the platform allows for differentiating between liquids electronically, for determining a liquid's molecular fingerprint, and for monitoring surface wetting dynamics in real time. In order to explore the platform's sensitivity limits, we record topographies and optical spectra of individual, spatiall...

  11. A Ubiquitous Sensor Network Platform for Integrating Smart Devices into the Semantic Sensor Web

    Directory of Open Access Journals (Sweden)

    David Díaz Pardo de Vera

    2014-06-01

    Full Text Available Ongoing Sensor Web developments make a growing amount of heterogeneous sensor data available to smart devices. This is generating an increasing demand for homogeneous mechanisms to access, publish and share real-world information. This paper discusses, first, an architectural solution based on Next Generation Networks: a pilot Telco Ubiquitous Sensor Network (USN Platform that embeds several OGC® Sensor Web services. This platform has already been deployed in large scale projects. Second, the USN-Platform is extended to explore a first approach to Semantic Sensor Web principles and technologies, so that smart devices can access Sensor Web data, allowing them also to share richer (semantically interpreted information. An experimental scenario is presented: a smart car that consumes and produces real-world information which is integrated into the Semantic Sensor Web through a Telco USN-Platform. Performance tests revealed that observation publishing times with our experimental system were well within limits compatible with the adequate operation of smart safety assistance systems in vehicles. On the other hand, response times for complex queries on large repositories may be inappropriate for rapid reaction needs.

  12. Model Driven Architecture (MDA: Integration and Model Reuse for Open Source eLearning Platforms

    Directory of Open Access Journals (Sweden)

    Blasius Lofi Dewanto

    2005-02-01

    Full Text Available Open Source (OS community offers numerous eLearning platforms of both types: Learning Management Systems (LMS and Learning Content Systems (LCS. General purpose OS intermediaries such as SourceForge, ObjectWeb, Apache or specialized intermediaries like CampusSource reduce the cost to locate such eLearning platforms. Still, it is impossible to directly compare the functionalities of those OS software products without performing detailed testing on each product. Some articles available from eLearning Wikipedia show comparisons between eLearning platforms which can help, but at the end they barely serve as documentation which are becoming out of date quickly (1. The absence of integration activities between OS eLearning platforms - which are sometimes quite similar in terms of functionalities and implementation technologies - is sometimes critical since most of the OS projects possess small financial and human resources. This paper shows a possible solution for these barriers of OS eLearning platforms. We propose the Model Driven Architecture (MDA concept to capture functionalities and to identify similarities between available OS eLearning platforms. This contribution evolved from a fruitful discussion at the 2nd CampusSource Developer Conference at the University of Muenster (27th August 2004.Die Open Source-Community bietet zahlreiche eLearning-Plattformen an: Learning Management-Systeme (LMS sowie Learning Content-Systeme (LCS. Allgemeine Open-Source-Mediatoren, wie SourceForge, ObjectWeb, Apache und der eLearning-spezifische Mediator CampusSource ermöglichen eine einfache Suche nach eLearning-Softwareprodukten. Ein Vergleich unterschiedlicher Plattformen in Bezug auf ihre Funktionalitäten ist jedoch aufwändig. Beiträge aus der “eLearning Wikipedia” können kaum als Entscheidungsgrundlage genutzt werden, da sie schnell veraltet sind (1. Zudem fehlen derzeit Aktivitäten zur Integration von Open Source-eLearning-Plattformen, die oft

  13. Information Integration Platform for Patient-Centric Healthcare Services: Design, Prototype and Dependability Aspects

    Directory of Open Access Journals (Sweden)

    Yohanes Baptista Dafferianto Trinugroho

    2014-03-01

    Full Text Available Technology innovations have pushed today’s healthcare sector to an unprecedented new level. Various portable and wearable medical and fitness devices are being sold in the consumer market to provide the self-empowerment of a healthier lifestyle to society. Many vendors provide additional cloud-based services for devices they manufacture, enabling the users to visualize, store and share the gathered information through the Internet. However, most of these services are integrated with the devices in a closed “silo” manner, where the devices can only be used with the provided services. To tackle this issue, an information integration platform (IIP has been developed to support communications between devices and Internet-based services in an event-driven fashion by adopting service-oriented architecture (SOA principles and a publish/subscribe messaging pattern. It follows the “Internet of Things” (IoT idea of connecting everyday objects to various networks and to enable the dissemination of the gathered information to the global information space through the Internet. A patient-centric healthcare service environment is chosen as the target scenario for the deployment of the platform, as this is a domain where IoT can have a direct positive impact on quality of life enhancement. This paper describes the developed platform, with emphasis on dependability aspects, including availability, scalability and security.

  14. Nickel has biochemical, physiological, and structural effects on the green microalga Ankistrodesmus falcatus: An integrative study.

    Science.gov (United States)

    Martínez-Ruiz, Erika Berenice; Martínez-Jerónimo, Fernando

    2015-12-01

    In recent years, the release of chemical pollutants to water bodies has increased due to anthropogenic activities. Ni(2+) is an essential metal that causes damage to aquatic biota at high concentrations. Phytoplankton are photosynthesizing microscopic organisms that constitute a fundamental community in aquatic environments because they are primary producers that sustain the aquatic food web. Nickel toxicity has not been characterized in all of the affected levels of biological organization. For this reason, the present study evaluated the toxic effects of nickel on the growth of a primary producer, the green microalga Ankistrodesmus falcatus, and on its biochemical, enzymatic, and structural levels. The IC50 (96h) was determined for Ni(2+). Based on this result, five concentrations were determined for additional tests, in which cell density was evaluated daily. At the end of the assay, pigments and six biomarkers, including antioxidant enzymes (catalase [CAT], glutathione peroxidase [GPx], superoxide dismutase [SOD]), and macromolecules (proteins, carbohydrates and lipids), were quantified; the integrated biomarker response (IBR) was determined also. The microalgae were observed by SEM and TEM. Population growth was affected starting at 7.5 μg L(-1) (0.028 μM), and at 120 μg L(-1) (0.450 μM), growth was inhibited completely; the determined IC50 was 17 μg L(-1). Exposure to nickel reduced the concentration of pigments, decreased the content of all of the macromolecules, inhibited of SOD activity, and increased CAT and GPx activities. The IBR revealed that Ni(2+) increased the antioxidant response and diminished the macromolecules concentration. A. falcatus was affected by nickel at very low concentrations; negative effects were observed at the macromolecular, enzymatic, cytoplasmic, and morphological levels, as well as in population growth. Ni(2+) toxicity could result in environmental impacts with consequences on the entire aquatic community. Current

  15. An Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits.

    Science.gov (United States)

    Kim, So W; Gupta, Ravi; Lee, Seo H; Min, Cheol W; Agrawal, Ganesh K; Rakwal, Randeep; Kim, Jong B; Jo, Ick H; Park, Soo-Yun; Kim, Jae K; Kim, Young-Chang; Bang, Kyong H; Kim, Sun T

    2016-01-01

    Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. In this study, we used an integrated biochemical, proteomics, and metabolomics approach to look into the medicinal properties of ginseng fruits. DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] assays showed higher antioxidant activities in ginseng fruits than leaves or roots. Two-dimensional gel electrophoresis (2-DE) profiling of ginseng fruit proteins (cv. Cheongsun) showed more than 400 spots wherein a total of 81 protein spots were identified by mass spectrometry using NCBInr, UniRef, and an in-house developed RNAseq (59,251 protein sequences)-based databases. Gene ontology analysis showed that most of the identified proteins were related to the hydrolase (18%), oxidoreductase (16%), and ATP binding (15%) activities. Further, a comparative proteome analysis of four cultivars of ginseng fruits (cvs. Yunpoong, Gumpoong, Chunpoong, and Cheongsun) led to the identification of 22 differentially modulated protein spots. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 66 metabolites including amino acids, sugars, organic acids, phenolic acids, phytosterols, tocopherols, and policosanols were identified and quantified. Some of these are well known medicinal compounds and were not previously identified in ginseng. Interestingly, the concentration of almost all metabolites was higher in the Chunpoong and Gumpoong cultivars. Parallel comparison of the four cultivars also revealed higher amounts of the medicinal metabolites in Chunpoong and Gumpoong cultivars. Taken together, our results demonstrate that ginseng fruits are a rich source of medicinal compounds with potential beneficial health effects. PMID:27458475

  16. An Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits

    Science.gov (United States)

    Kim, So W.; Gupta, Ravi; Lee, Seo H.; Min, Cheol W.; Agrawal, Ganesh K.; Rakwal, Randeep; Kim, Jong B.; Jo, Ick H.; Park, Soo-Yun; Kim, Jae K.; Kim, Young-Chang; Bang, Kyong H.; Kim, Sun T.

    2016-01-01

    Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. In this study, we used an integrated biochemical, proteomics, and metabolomics approach to look into the medicinal properties of ginseng fruits. DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] assays showed higher antioxidant activities in ginseng fruits than leaves or roots. Two-dimensional gel electrophoresis (2-DE) profiling of ginseng fruit proteins (cv. Cheongsun) showed more than 400 spots wherein a total of 81 protein spots were identified by mass spectrometry using NCBInr, UniRef, and an in-house developed RNAseq (59,251 protein sequences)-based databases. Gene ontology analysis showed that most of the identified proteins were related to the hydrolase (18%), oxidoreductase (16%), and ATP binding (15%) activities. Further, a comparative proteome analysis of four cultivars of ginseng fruits (cvs. Yunpoong, Gumpoong, Chunpoong, and Cheongsun) led to the identification of 22 differentially modulated protein spots. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 66 metabolites including amino acids, sugars, organic acids, phenolic acids, phytosterols, tocopherols, and policosanols were identified and quantified. Some of these are well known medicinal compounds and were not previously identified in ginseng. Interestingly, the concentration of almost all metabolites was higher in the Chunpoong and Gumpoong cultivars. Parallel comparison of the four cultivars also revealed higher amounts of the medicinal metabolites in Chunpoong and Gumpoong cultivars. Taken together, our results demonstrate that ginseng fruits are a rich source of medicinal compounds with potential beneficial health effects. PMID:27458475

  17. An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures

    Directory of Open Access Journals (Sweden)

    Sherwin Ting

    2014-09-01

    In conclusion, we have developed a simple robust and scalable platform that integrates both hESC expansion and CM differentiation in one unit process which is capable of meeting the need for large amounts of CMs.

  18. Tile-in-ONE: A web platform which integrates Tile Calorimeter data quality and calibration assessment

    Science.gov (United States)

    Sivolella, A.; Ferreira, F.; Maidantchik, C.; Solans, C.; Solodkov, A.; Burghgrave, B.; Smirnov, Y.

    2015-12-01

    The ATLAS Tile Calorimeter collaboration assesses the quality of calibration data in order to ensure its proper operation. A number of tasks is then performed by executing several tools and accessing web systems, which were independently developed to meet distinct collaboration's requirements and do not necessarily are connected with each other. Thus, to attend the collaboration needs, several programs are usually implemented without a global perspective of the detector, requiring basic software features. In addition, functionalities may overlap in their objectives and frequently replicate resources retrieval mechanisms. Tile-in-ONE is a designed and implemented platform that assembles various web systems used by the calorimeter community through a single framework and a standard technology. It provides an infrastructure to support the code implementation, avoiding duplication of work while integrating with an overall view of the detector status. Database connectors smooth the process of information access since developers do not need to be aware of where records are placed and how to extract them. Within the environment, a dashboard stands for a particular Tile operation aspect and gets together plug-ins, i.e. software components that add specific features to an existing application. A server contains the platform core, which represents the basic environment to deal with the configuration, manage user settings and load plug-ins at runtime. A web middleware assists users to develop their own plug-ins, perform tests and integrate them into the platform as a whole. Backends are employed to allow that any type of application is interpreted and displayed in a uniform way. This paper describes Tile-in-ONE web platform.

  19. Supporting Building Portfolio Investment and Policy Decision Making through an Integrated Building Utility Data Platform

    Energy Technology Data Exchange (ETDEWEB)

    Aziz, Azizan [Carnegie Mellon Univ., Pittsburgh, PA (United States); Lasternas, Bertrand [Carnegie Mellon Univ., Pittsburgh, PA (United States); Alschuler, Elena [US DOE; View Inc; Loftness, Vivian [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Haopeng [Carnegie Mellon Univ., Pittsburgh, PA (United States); Mo, Yunjeong [Carnegie Mellon Univ., Pittsburgh, PA (United States); Wang, Ting [Carnegie Mellon Univ., Pittsburgh, PA (United States); Zhang, Chenlu [Carnegie Mellon Univ., Pittsburgh, PA (United States); Sharma, Shilpi [Carnegie Mellon; Stevens, Ivana [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-03-18

    The American Recovery and Reinvestment Act stimulus funding of 2009 for smart grid projects resulted in the tripling of smart meters deployment. In 2012, the Green Button initiative provided utility customers with access to their real-time1 energy usage. The availability of finely granular data provides an enormous potential for energy data analytics and energy benchmarking. The sheer volume of time-series utility data from a large number of buildings also poses challenges in data collection, quality control, and database management for rigorous and meaningful analyses. In this paper, we will describe a building portfolio-level data analytics tool for operational optimization, business investment and policy assessment using 15-minute to monthly intervals utility data. The analytics tool is developed on top of the U.S. Department of Energy’s Standard Energy Efficiency Data (SEED) platform, an open source software application that manages energy performance data of large groups of buildings. To support the significantly large volume of granular interval data, we integrated a parallel time-series database to the existing relational database. The time-series database improves on the current utility data input, focusing on real-time data collection, storage, analytics and data quality control. The fully integrated data platform supports APIs for utility apps development by third party software developers. These apps will provide actionable intelligence for building owners and facilities managers. Unlike a commercial system, this platform is an open source platform funded by the U.S. Government, accessible to the public, researchers and other developers, to support initiatives in reducing building energy consumption.

  20. Integrated opto-microfluidics platforms in lithium niobate crystals for sensing applications

    Science.gov (United States)

    Bettella, G.; Pozza, G.; Zaltron, A.; Ciampolillo, M. V.; Argiolas, N.; Sada, C.; Chauvet, M.; Guichardaz, B.

    2015-02-01

    In micro-analytical chemistry and biology applications, droplet microfluidic technology holds great promise for efficient lab-on-chip systems where higher levels of integration of different stages on the same platform is constantly addressed. The possibility of integration of opto-microfluidic functionalities in lithium niobate (LiNbO3) crystals is presented. Microfluidic channels were directly engraved in a LiNbO3 substrate by precision saw cutting, and illuminated by optical waveguides integrated on the same substrate. The morphological characterization of the microfluidic channel and the optical response of the coupled optical waveguide were tested. In particular, the results indicate that the optical properties of the constituents dispersed in the fluid flowing in the microfluidic channel can be monitored in situ, opening to new compact optical sensor prototypes based on droplets generation and optical analysis of the relative constituents.

  1. MAID : An effect size based model for microarray data integration across laboratories and platforms

    Directory of Open Access Journals (Sweden)

    Edwards Aled M

    2008-07-01

    Full Text Available Abstract Background Gene expression profiling has the potential to unravel molecular mechanisms behind gene regulation and identify gene targets for therapeutic interventions. As microarray technology matures, the number of microarray studies has increased, resulting in many different datasets available for any given disease. The increase in sensitivity and reliability of measurements of gene expression changes can be improved through a systematic integration of different microarray datasets that address the same or similar biological questions. Results Traditional effect size models can not be used to integrate array data that directly compare treatment to control samples expressed as log ratios of gene expressions. Here we extend the traditional effect size model to integrate as many array datasets as possible. The extended effect size model (MAID can integrate any array datatype generated with either single or two channel arrays using either direct or indirect designs across different laboratories and platforms. The model uses two standardized indices, the standard effect size score for experiments with two groups of data, and a new standardized index that measures the difference in gene expression between treatment and control groups for one sample data with replicate arrays. The statistical significance of treatment effect across studies for each gene is determined by appropriate permutation methods depending on the type of data integrated. We apply our method to three different expression datasets from two different laboratories generated using three different array platforms and two different experimental designs. Our results indicate that the proposed integration model produces an increase in statistical power for identifying differentially expressed genes when integrating data across experiments and when compared to other integration models. We also show that genes found to be significant using our data integration method are of direct

  2. Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling.

    Science.gov (United States)

    Shang, Yuqin; Zeng, Yun; Zeng, Yong

    2016-01-01

    Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges in analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and speed of lectin microarray. Moreover, we established an on-chip lectin assay which employs a very simple blocking method to effectively suppress the undesired background due to lectin binding of antibodies. Using this technology, we demonstrated focused differential profiling of tissue-specific glycosylation changes of a biomarker, CA125 protein purified from ovarian cancer cell line and different tissues from ovarian cancer patients in a fast, reproducible, and high-throughput fashion. Highly sensitive CA125 detection was also demonstrated with a detection limit much lower than the clinical cutoff value for cancer diagnosis. This microfluidic platform holds the potential to integrate with sample preparation functions to construct a fully integrated "sample-to-answer" microsystem for focused differential glycomic analysis. Thus, our technology should present a powerful tool in support of rapid advance in glycobiology and glyco-biomarker development. PMID:26831207

  3. Relationship between changes in rat behavior and integral biochemical indexes determined by laser correlation spectroscopy after photothrombosis of the prefrontal cortex.

    Science.gov (United States)

    Romanova, G A; Shakova, F M; Kovaleva, O I; Pivovarov, V V; Khlebnikova, N N; Karganov, M Yu

    2004-02-01

    Experiments on rats showed that Noopept improved retention and retrieval of conditioned passive avoidance response after phototrombosis of the prefrontal cortex (a procedure impairing retention of memory traces). The impairment of mnesic functions was accompanied by changes in integral biochemical indexes of the plasma determined by laser correlation spectroscopy. Treatment of behavioral disorders with Noopepet normalized biochemical indexes. PMID:15273757

  4. Bio-jETI: a service integration, design, and provisioning platform for orchestrated bioinformatics processes

    OpenAIRE

    Margaria, Tiziana; Kubczak, Christian; Steffen, Bernhard

    2008-01-01

    Background With Bio-jETI, we introduce a service platform for interdisciplinary work on biological application domains and illustrate its use in a concrete application concerning statistical data processing in R and xcms for an LC/MS analysis of FAAH gene knockout. Methods Bio-jETI uses the jABC environment for service-oriented modeling and design as a graphical process modeling tool and the jETI service integration technology for remote tool execution. Conclusions As a service definition and...

  5. CoreFlow: A computational platform for integration, analysis and modeling of complex biological data

    OpenAIRE

    Pasculescu, Adrian; Schoof, Erwin; Creixell, Pau; Zheng, Yong; Olhovsky, Marina; Tian, Ruijun; So, Jonathan; Vanderlaan, Rachel D.; Pawson, Tony; Linding, Rune; Colwill, Karen

    2014-01-01

    A major challenge in mass spectrometry and other large-scale applications is how to handle, integrate, and model the data that is produced. Given the speed at which technology advances and the need to keep pace with biological experiments, we designed a computational platform, CoreFlow, which provides programmers with a framework to manage data in real-time. It allows users to upload data into a relational database (MySQL), and to create custom scripts in high-level languages such as R, Pytho...

  6. Integrated Modelling Platform for Dynamic Performance Assessment of Floating Wind Turbines

    OpenAIRE

    Endegnanew, Atsede Gualu; Satertro, Kristian; Gjerde, Sverre Skalleberg; Svendsen, Harald Georg; Anaya-Lara, Olimpo; Tande, John Olav Giæver; Uhlen, Kjetil; Gjolmesli, Svein

    2015-01-01

    The paper presents an integrated modelling platform that can be used to assess the dynamic performance of an offshore wind turbine mounted on a spar-buoy type floater. Sub-models of generator and converter controllers and the power network are combined with a state-of-the-art numerical simulation of the hydro-, aero- and structural dynamic behavior of the floating wind turbine, using FEDEM Windpower software. The aim is to provide a tool that allows analyzing response of floating turbines to ...

  7. Integrated micro-optofluidic platform for real-time detection of airborne microorganisms

    Science.gov (United States)

    Choi, Jeongan; Kang, Miran; Jung, Jae Hee

    2015-11-01

    We demonstrate an integrated micro-optofluidic platform for real-time, continuous detection and quantification of airborne microorganisms. Measurements of the fluorescence and light scattering from single particles in a microfluidic channel are used to determine the total particle number concentration and the microorganism number concentration in real-time. The system performance is examined by evaluating standard particle measurements with various sample flow rates and the ratios of fluorescent to non-fluorescent particles. To apply this method to real-time detection of airborne microorganisms, airborne Escherichia coli, Bacillus subtilis, and Staphylococcus epidermidis cells were introduced into the micro-optofluidic platform via bioaerosol generation, and a liquid-type particle collection setup was used. We demonstrate successful discrimination of SYTO82-dyed fluorescent bacterial cells from other residue particles in a continuous and real-time manner. In comparison with traditional microscopy cell counting and colony culture methods, this micro-optofluidic platform is not only more accurate in terms of the detection efficiency for airborne microorganisms but it also provides additional information on the total particle number concentration.

  8. Miniaturized Integrated Platform for Electrical and Optical Monitoring of Cell Cultures

    Directory of Open Access Journals (Sweden)

    Costin Brasoveanu

    2012-08-01

    Full Text Available The following paper describes the design and functions of a miniaturized integrated platform for optical and electrical monitoring of cell cultures and the necessary steps in the fabrication and testing of a silicon microchip Micro ElectroMechanical Systems (MEMS-based technology for cell data recording, monitoring and stimulation. The silicon microchip consists of a MEMS machined device containing a shank of 240 μm width, 3 mm long and 50 μm thick and an enlarged area of 5 mm × 5 mm hosting the pads for electrical connections. Ten platinum electrodes and five sensors are placed on the shank and are connected with the external electronics through the pads. The sensors aim to monitor the pH, the temperature and the impedance of the cell culture. The electrodes are bidirectional and can be used both for electrical potential recording and stimulation of cells. The fabrication steps are presented, along with the electrical and optical characterization of the system. The target of the research is to develop a new and reconfigurable platform according to the particular applications needs, as a tool for the biologist, chemists and medical doctors working is the field of cell culture monitoring in terms of growth, maintenance conditions, reaction to electrical or chemical stimulation (drugs, toxicants, etc.. HaCaT (Immortalised Human Keratinocyte cell culture has been used for demonstration purposes in order to provide information on the platform electrical and optical functions.

  9. Using a blog as an integrated eLearning tool and platform.

    Science.gov (United States)

    Goh, Poh Sun

    2016-06-01

    Technology enhanced learning or eLearning allows educators to expand access to educational content, promotes engagement with students and makes it easier for students to access educational material at a time, place and pace which suits them. The challenge for educators beginning their eLearning journey is to decide where to start, which includes the choice of an eLearning tool and platform. This article will share one educator's decision making process, and experience using blogs as a flexible and versatile integrated eLearning tool and platform. Apart from being a cost effective/free tool and platform, blogs offer the possibility of creating a hyperlinked indexed content repository, for both created and curated educational material; as well as a distribution and engagement tool and platform. Incorporating pedagogically sound activities and educational practices into a blog promote a structured templated teaching process, which can be reproduced. Moving from undergraduate to postgraduate training, educational blogs supported by a comprehensive online case-based repository offer the possibility of training beyond competency towards proficiency and expert level performance through a process of deliberate practice. By documenting educational content and the student engagement and learning process, as well as feedback and personal reflection of educational sessions, blogs can also form the basis for a teaching portfolio, and provide evidence and data of scholarly teaching and educational scholarship. Looking into the future, having a collection of readily accessible indexed hyperlinked teaching material offers the potential to do on the spot teaching with illustrative material called up onto smart surfaces, and displayed on holographic interfaces. PMID:26558420

  10. Integrated FBG sensors interrogator in silicon photonic platform using active interferometer monitoring

    Science.gov (United States)

    Marin, Y. E.; Nannipieri, T.; Di Pasquale, F.; Oton, C. J.

    2016-05-01

    We experimentally demonstrate the feasibility of Fiber Bragg Grating sensors interrogation using integrated unbalanced Mach-Zehnder Interferometers (MZI) and phase sensitive detection in silicon-on-insulator (SOI) platform. The Phase- Generated Carrier (PGC) demodulation technique is used to detect phase changes, avoiding signal fading. Signal processing allows us to extract the wavelength shift from the signal patterns, allowing accurate dynamic FBG interrogation. High resolution and low cost chips with multiple interrogators and photodetectors on board can be realized by exploiting the advantages of large scale fabrication capabilities of well-established silicon based industrial infrastructures. Simultaneous dynamic reading of a large number of FBG sensors can lead to large volume market applications of the technology in several strategic industrial fields. The performance of the proposed integrated FBG interrogator is validated by comparing with a commercial FBG readout based on a spectrometer and used as a reference.

  11. Integrated III-V Photonic Crystal - Si waveguide platform with tailored optomechanical coupling

    Science.gov (United States)

    Tsvirkun, Viktor; Surrente, Alessandro; Raineri, Fabrice; Beaudoin, Grégoire; Raj, Rama; Sagnes, Isabelle; Robert-Philip, Isabelle; Braive, Rémy

    2015-11-01

    Optomechanical systems, in which the vibrations of a mechanical resonator are coupled to an electromagnetic radiation, have permitted the investigation of a wealth of novel physical effects. To fully exploit these phenomena in realistic circuits and to achieve different functionalities on a single chip, the integration of optomechanical resonators is mandatory. Here, we propose a novel approach to heterogeneously integrate arrays of two-dimensional photonic crystal defect cavities on top of silicon-on-insulator waveguides. The optomechanical response of these devices is investigated and evidences an optomechanical coupling involving both dispersive and dissipative mechanisms. By controlling the optical coupling between the waveguide and the photonic crystal, we were able to vary and understand the relative strength of these couplings. This scalable platform allows for an unprecedented control on the optomechanical coupling mechanisms, with a potential benefit in cooling experiments, and for the development of multi-element optomechanical circuits in the framework of optomechanically-driven signal-processing applications.

  12. An integrated optical platform for micromanipulation of cells and tissue in live animals

    Science.gov (United States)

    Turcotte, Raphael

    The hematopoietic stem cell niche is a specialized bone marrow (BM) microenvironment where blood-forming cells reside. Interactions between these rare cells and their niche need to be studied at the single-cell level. While live animal cell tracking with optical microscopy has proven useful for this purpose, a more thorough characterization requires novel approaches. This can be accomplished by using an integrated optical platform for cell and tissue manipulations (cell transplantation and extraction) in the skull bone of live mice. The platform integrates a non-damaging laser ablation microbeam for bone removal and tissue cutting, optical tweezers for single cell trapping, and a video-rate scanning microscope. For single cell delivery, a narrow channel is ablated through bone under imaging guidance. Cells are then transferred from a micropipette into an optical trap, which brings cells into the BM through the channel. The survival and proliferation of implanted cells can be tracked in vivo by imaging. For cell extraction after laser bone thinning, different approaches can be implemented and three of them are presented.

  13. BiGG Models: A platform for integrating, standardizing and sharing genome-scale models

    DEFF Research Database (Denmark)

    2016-01-01

    Genome-scale metabolic models are mathematically-structured knowledge bases that can be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can generate and test hypotheses when integrated with experimental data. To maximize the value of these models, centralized...... repositories of high-quality models must be established, models must adhere to established standards and model components must be linked to relevant databases. Tools for model visualization further enhance their utility. To meet these needs, we present BiGG Models (http://bigg.ucsd.edu), a completely...... redesigned Biochemical, Genetic and Genomic knowledge base. BiGG Models contains more than 75 high-quality, manually-curated genome-scale metabolic models. On the website, users can browse, search and visualize models. BiGG Models connects genome-scale models to genome annotations and external databases...

  14. An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

    International Nuclear Information System (INIS)

    Highlights: • Integrated platform was developed to determine ethanol in fermentation broths. • The designed system integrates gas diffusion separation with voltammetric detection. • Detector relied on Ni(OH)2-modified electrode stabilized by Co2+ and Cd2+ insertion. • Separation was made by PTFE membrane separating sample from electrolyte (receptor). • Despite the sample complexity, accurate tests were achieved by direct interpolation. - Abstract: An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module. The detector relied on a Ni(OH)2-modified electrode. It was stabilized by uniformly depositing cobalt and cadmium hydroxides as shown by XPS measurements. Such tests were in accordance with the hypothesis related to stabilization of the Ni(OH)2 structure by insertion of Co2+ and Cd2+ ions in this structure. The separation step, in turn, was based on a hydrophobic PTFE membrane, which separates the sample from receptor solution (electrolyte) where the electrodes were placed. Parameters of limit of detection and analytical sensitivity were estimated to be 0.2% v/v and 2.90 μA % (v/v)−1, respectively. Samples of fermentation broth were analyzed by both standard addition method and direct interpolation in saline medium based-analytical curve. In this case, the saline solution exhibited ionic strength similar to those of the samples intended to surpass the tonometry colligative effect of the samples over analyte concentration data by attributing the reduction in quantity of diffused ethanol vapor majorly to the electrolyte. The approach of analytical curve provided rapid, simple and accurate analysis, thus contributing for deployment of point

  15. An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Gabriela Furlan [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Vieira, Luis Carlos Silveira; Gobbi, Angelo Luiz [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Lima, Renato Sousa [Microfabrication Laboratory, Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970 (Brazil); Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); Kubota, Lauro Tatsuo, E-mail: kubota@iqm.unicamp.br [Department of Analytical Chemistry, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil); National Institute of Science and Technology of Bioanalytics, Institute of Chemistry – UNICAMP, Campinas, SP 13083-970 (Brazil)

    2015-05-22

    Highlights: • Integrated platform was developed to determine ethanol in fermentation broths. • The designed system integrates gas diffusion separation with voltammetric detection. • Detector relied on Ni(OH){sub 2}-modified electrode stabilized by Co{sup 2+} and Cd{sup 2+} insertion. • Separation was made by PTFE membrane separating sample from electrolyte (receptor). • Despite the sample complexity, accurate tests were achieved by direct interpolation. - Abstract: An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module. The detector relied on a Ni(OH){sub 2}-modified electrode. It was stabilized by uniformly depositing cobalt and cadmium hydroxides as shown by XPS measurements. Such tests were in accordance with the hypothesis related to stabilization of the Ni(OH){sub 2} structure by insertion of Co{sup 2+} and Cd{sup 2+} ions in this structure. The separation step, in turn, was based on a hydrophobic PTFE membrane, which separates the sample from receptor solution (electrolyte) where the electrodes were placed. Parameters of limit of detection and analytical sensitivity were estimated to be 0.2% v/v and 2.90 μA % (v/v){sup −1}, respectively. Samples of fermentation broth were analyzed by both standard addition method and direct interpolation in saline medium based-analytical curve. In this case, the saline solution exhibited ionic strength similar to those of the samples intended to surpass the tonometry colligative effect of the samples over analyte concentration data by attributing the reduction in quantity of diffused ethanol vapor majorly to the electrolyte. The approach of analytical curve provided rapid, simple and accurate

  16. Integrated semantics service platform for the Internet of Things: a case study of a smart office.

    Science.gov (United States)

    Ryu, Minwoo; Kim, Jaeho; Yun, Jaeseok

    2015-01-01

    The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability. PMID:25608216

  17. Correlation of serum arylesterase activity on phenylacetate estimated by the integrated method to common classical biochemical indexes of liver damage

    Institute of Scientific and Technical Information of China (English)

    LIAO Fei; ZHU Xiao-yun; WANG Yong-mei; ZHAO Yun-sheng; ZHU Lian-ping; ZUO Yu-ping

    2007-01-01

    The correlation of serum arylesterase (PON1) activity on phenylacetate determined by an integrated method to classical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate liver damage. PON1 reaction curve as absorbance at 270 nm for 0.20 mmol/L phenylacetate hydrolysis was analyzed by the integrated method to determine maximal PON1 reaction rate. Classical biochemical indexes of liver damage were determined routinely. The 95% confidence threshold of PON1 activity in sera from healthy individuals was 2.12 mkat/L [(4.73±1.31) mkat/L, n=105]. PON1 activity in clinical sera was closely correlated to serum albumin, total protein and the ratio of albumin to globulins, but was weakly correlated to both direct and total bilirubin in serum. There were no correlations of PON1 activity to γ-glutamyltransferase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. Among 127 clinical sera with PON1 activity>2.12 mkat/L, there were 92% healthy individuals examined by albumin, 90% healthy individuals examined by total protein, 88% healthy individuals examined by total bilirubin, 86% healthy individuals examined by direct bilirubin and 64% healthy individuals examined by the ratio of albumin to globulins, respectively. In each group of healthy individuals judged by classical biochemical indexes of close correlation to PON1 activity, percentage of healthy individuals examined by PON1 activity was always >80%. These results suggested PON1 activity on phenylacetate estimated by the integrated method was also suitable for the evaluation of liver damage.

  18. An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.

    Directory of Open Access Journals (Sweden)

    Timothy Kassis

    2014-11-01

    Full Text Available Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for years, often resulting in lymphedema, elephantiasis or hydrocele. The mechanisms driving worm migration and retention within the lymphatics are currently unknown. We have developed an integrated in vitro imaging platform capable of quantifying B. malayi migration and behavior in a multicellular microenvironment relevant to the initial site of worm injection by incorporating the worm in a Polydimethylsiloxane (PDMS microchannel in the presence of human dermal lymphatic endothelial cells (LECs and human dermal fibroblasts (HDFs. The platform utilizes a motorized controllable microscope with CO2 and temperature regulation to allow for worm tracking experiments with high resolution over large length and time scales. Using post-acquisition algorithms, we quantified four parameters: 1 speed, 2 thrashing intensity, 3 percentage of time spent in a given cell region and 4 persistence ratio. We demonstrated the utility of our system by quantifying these parameters for L3 B. malayi in the presence of LECs and HDFs. Speed and thrashing increased in the presence of both cell types and were altered within minutes upon exposure to the anthelmintic drug, tetramisole. The worms displayed no targeted migration towards either cell type for the time course of this study (3 hours. When cells were not present in the chamber, worm thrashing correlated directly with worm speed. However, this correlation was lost in the presence of cells. The described platform provides the ability to further study B. malayi migration and behavior.

  19. Integrated experimental platforms to study blast injuries: a bottom-up approach

    Science.gov (United States)

    Bo, C.; Williams, A.; Rankin, S.; Proud, W. G.; Brown, K. A.

    2014-05-01

    We are developing experimental models of blast injury using data from live biological samples. An integrated research strategy is followed to study material and biological properties of cells, tissues and organs, that are subjected to dynamic and static pressures, relevant to those of battlefield blast. We have developed a confined Split Hopkinson Pressure Bar (SHPB) system, which allows cells, either in suspension or as a monolayer, to be subjected to compression waves with pressures on the order of a few MPa and durations of hundreds of microseconds. The chamber design enables recovery of biological samples for cellular and molecular analysis. The SHPB platform, coupled with Quasi-Static experiments, is used to determine stress-strain curves of soft biological tissues under compression at low, medium and high strain rates. Tissue samples are examined, using histological techniques, to study macro- and microscopic changes induced by compression waves. In addition, a shock tube enables application of single or multiple air blasts with pressures on the order of kPa and a few milliseconds duration; this platform was used for initial studies on mesenchymal stem cells responses to blast pressures.

  20. Integrated plasmonic circuitry on a vertical-cavity surface-emitting semiconductor laser platform

    Science.gov (United States)

    McPolin, Cillian P. T.; Bouillard, Jean-Sebastien; Vilain, Sebastien; Krasavin, Alexey V.; Dickson, Wayne; O'Connor, Daniel; Wurtz, Gregory A.; Justice, John; Corbett, Brian; Zayats, Anatoly V.

    2016-08-01

    Integrated plasmonic sources and detectors are imperative in the practical development of plasmonic circuitry for bio- and chemical sensing, nanoscale optical information processing, as well as transducers for high-density optical data storage. Here we show that vertical-cavity surface-emitting lasers (VCSELs) can be employed as an on-chip, electrically pumped source or detector of plasmonic signals, when operated in forward or reverse bias, respectively. To this end, we experimentally demonstrate surface plasmon polariton excitation, waveguiding, frequency conversion and detection on a VCSEL-based plasmonic platform. The coupling efficiency of the VCSEL emission to waveguided surface plasmon polariton modes has been optimized using asymmetric plasmonic nanostructures. The plasmonic VCSEL platform validated here is a viable solution for practical realizations of plasmonic functionalities for various applications, such as those requiring sub-wavelength field confinement, refractive index sensitivity or optical near-field transduction with electrically driven sources, thus enabling the realization of on-chip optical communication and lab-on-a-chip devices.

  1. An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology.

    Science.gov (United States)

    Taylor, Donald P

    2007-01-01

    High content screening (HCS) requires time-consuming and often complex iterative information retrieval and assessment approaches to optimally conduct drug discovery programs and biomedical research. Pre- and post-HCS experimentation both require the retrieval of information from public as well as proprietary literature in addition to structured information assets such as compound libraries and projects databases. Unfortunately, this information is typically scattered across a plethora of proprietary bioinformatics tools and databases and public domain sources. Consequently, single search requests must be presented to each information repository, forcing the results to be manually integrated for a meaningful result set. Furthermore, these bioinformatics tools and data repositories are becoming increasingly complex to use; typically they fail to allow for more natural query interfaces. Vivisimo has developed an enterprise software platform to bridge disparate silos of information. The platform automatically categorizes search results into descriptive folders without the use of taxonomies to drive the categorization. A new approach to information retrieval for HCS experimentation is proposed. PMID:16988412

  2. Integrated plasmonic circuitry on a vertical-cavity surface-emitting semiconductor laser platform

    Science.gov (United States)

    McPolin, Cillian P. T.; Bouillard, Jean-Sebastien; Vilain, Sebastien; Krasavin, Alexey V.; Dickson, Wayne; O'Connor, Daniel; Wurtz, Gregory A.; Justice, John; Corbett, Brian; Zayats, Anatoly V.

    2016-01-01

    Integrated plasmonic sources and detectors are imperative in the practical development of plasmonic circuitry for bio- and chemical sensing, nanoscale optical information processing, as well as transducers for high-density optical data storage. Here we show that vertical-cavity surface-emitting lasers (VCSELs) can be employed as an on-chip, electrically pumped source or detector of plasmonic signals, when operated in forward or reverse bias, respectively. To this end, we experimentally demonstrate surface plasmon polariton excitation, waveguiding, frequency conversion and detection on a VCSEL-based plasmonic platform. The coupling efficiency of the VCSEL emission to waveguided surface plasmon polariton modes has been optimized using asymmetric plasmonic nanostructures. The plasmonic VCSEL platform validated here is a viable solution for practical realizations of plasmonic functionalities for various applications, such as those requiring sub-wavelength field confinement, refractive index sensitivity or optical near-field transduction with electrically driven sources, thus enabling the realization of on-chip optical communication and lab-on-a-chip devices. PMID:27491686

  3. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

    Science.gov (United States)

    Hosoya, Hitomi; Dobroff, Andrey S; Driessen, Wouter H P; Cristini, Vittorio; Brinker, Lina M; Staquicini, Fernanda I; Cardó-Vila, Marina; D'Angelo, Sara; Ferrara, Fortunato; Proneth, Bettina; Lin, Yu-Shen; Dunphy, Darren R; Dogra, Prashant; Melancon, Marites P; Stafford, R Jason; Miyazono, Kohei; Gelovani, Juri G; Kataoka, Kazunori; Brinker, C Jeffrey; Sidman, Richard L; Arap, Wadih; Pasqualini, Renata

    2016-02-16

    A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications. PMID:26839407

  4. Tile-in-ONE: A web platform which integrates Tile Calorimeter data quality and calibration assessment

    CERN Document Server

    Sivolella Gomes, Andressa; The ATLAS collaboration; Maidantchik, Carmen; Solans, Carlos; Burghgrave, Blake; Solodkov, Alexander

    2015-01-01

    The ATLAS Tile Calorimeter assesses the quality of data in order to ensure its proper operation. A number of tasks are then performed by running several tools and systems, which were independently developed to meet distinct collaboration’s requirements and do not necessarily builds an effective connection among them. Thus, a program is usually implemented without a global perspective of the detector, requiring basic software features. In addition, functionalities may overlap in their objectives and frequently replicate resources retrieval mechanisms. Tile-in-ONE is a unique platform that assembles various web systems used by the calorimeter community through a single framework and a standard technology. It provides an infrastructure to support the code implementation, avoiding duplication of work while integrating with an overall view of the detector status. Database connectors smooth the process of information access since developers do not need to be aware of where records are placed and how to extract th...

  5. Applications integration in a hybrid cloud computing environment: modelling and platform

    Science.gov (United States)

    Li, Qing; Wang, Ze-yuan; Li, Wei-hua; Li, Jun; Wang, Cheng; Du, Rui-yang

    2013-08-01

    With the development of application services providers and cloud computing, more and more small- and medium-sized business enterprises use software services and even infrastructure services provided by professional information service companies to replace all or part of their information systems (ISs). These information service companies provide applications, such as data storage, computing processes, document sharing and even management information system services as public resources to support the business process management of their customers. However, no cloud computing service vendor can satisfy the full functional IS requirements of an enterprise. As a result, enterprises often have to simultaneously use systems distributed in different clouds and their intra enterprise ISs. Thus, this article presents a framework to integrate applications deployed in public clouds and intra ISs. A run-time platform is developed and a cross-computing environment process modelling technique is also developed to improve the feasibility of ISs under hybrid cloud computing environments.

  6. Integrating a Federated Healthcare Data Query Platform With Electronic IRB Information Systems.

    Science.gov (United States)

    He, Shan; Hurdle, John F; Botkin, Jeffrey R; Narus, Scott P

    2010-01-01

    Human subjects are indispensable for clinical and translational research. Federal and local agencies issue regulations governing the conduct of research involving human subjects in order to properly protect study participants. Institutional Review Boards (IRBs) have the authority to review human subject research to ensure concordance with these regulations. One of the primary goals of the IRB oversight is to protect research participants' privacy by carefully reviewing the data used and disclosed during a study. However, there are major challenges for IRBs in the typical research process. Due to the information disconnect between the data providers (e.g., a clinical data warehouse) and the IRB, it is often impossible to tell exactly what data has been disclosed to investigators. This causes time-consuming, inefficient, and often ineffective monitoring of clinical studies. This paper proposes an integrated architecture that interconnects a federated healthcare data query platform with an electronic IRB system. PMID:21346987

  7. Integrated numerical platforms for environmental dose assessments of large tritium inventory facilities

    International Nuclear Information System (INIS)

    Related with a prospected new scenario of large inventory tritium facilities [KATRIN at TLK, CANDUs, ITER, EAST, other coming] the prescribed dosimetric limits by ICRP-60 for tritium committed-doses are under discussion requiring, in parallel, to surmount the highly conservative assessments by increasing the refinement of dosimetric-assessments in many aspects. Precise Lagrangian-computations of dosimetric cloud-evolution after standardized (normal/incidental/SBO) tritium cloud emissions are today numerically open to the perfect match of real-time meteorological-data, and patterns data at diverse scales for prompt/early and chronic tritium dose assessments. The trends towards integrated-numerical-platforms for environmental-dose assessments of large tritium inventory facilities under development.

  8. Sparse canonical methods for biological data integration: application to a cross-platform study

    Directory of Open Access Journals (Sweden)

    Robert-Granié Christèle

    2009-01-01

    Full Text Available Abstract Background In the context of systems biology, few sparse approaches have been proposed so far to integrate several data sets. It is however an important and fundamental issue that will be widely encountered in post genomic studies, when simultaneously analyzing transcriptomics, proteomics and metabolomics data using different platforms, so as to understand the mutual interactions between the different data sets. In this high dimensional setting, variable selection is crucial to give interpretable results. We focus on a sparse Partial Least Squares approach (sPLS to handle two-block data sets, where the relationship between the two types of variables is known to be symmetric. Sparse PLS has been developed either for a regression or a canonical correlation framework and includes a built-in procedure to select variables while integrating data. To illustrate the canonical mode approach, we analyzed the NCI60 data sets, where two different platforms (cDNA and Affymetrix chips were used to study the transcriptome of sixty cancer cell lines. Results We compare the results obtained with two other sparse or related canonical correlation approaches: CCA with Elastic Net penalization (CCA-EN and Co-Inertia Analysis (CIA. The latter does not include a built-in procedure for variable selection and requires a two-step analysis. We stress the lack of statistical criteria to evaluate canonical correlation methods, which makes biological interpretation absolutely necessary to compare the different gene selections. We also propose comprehensive graphical representations of both samples and variables to facilitate the interpretation of the results. Conclusion sPLS and CCA-EN selected highly relevant genes and complementary findings from the two data sets, which enabled a detailed understanding of the molecular characteristics of several groups of cell lines. These two approaches were found to bring similar results, although they highlighted the same

  9. Purdue Ionomics Information Management System. An Integrated Functional Genomics Platform1[C][W][OA

    Science.gov (United States)

    Baxter, Ivan; Ouzzani, Mourad; Orcun, Seza; Kennedy, Brad; Jandhyala, Shrinivas S.; Salt, David E.

    2007-01-01

    The advent of high-throughput phenotyping technologies has created a deluge of information that is difficult to deal with without the appropriate data management tools. These data management tools should integrate defined workflow controls for genomic-scale data acquisition and validation, data storage and retrieval, and data analysis, indexed around the genomic information of the organism of interest. To maximize the impact of these large datasets, it is critical that they are rapidly disseminated to the broader research community, allowing open access for data mining and discovery. We describe here a system that incorporates such functionalities developed around the Purdue University high-throughput ionomics phenotyping platform. The Purdue Ionomics Information Management System (PiiMS) provides integrated workflow control, data storage, and analysis to facilitate high-throughput data acquisition, along with integrated tools for data search, retrieval, and visualization for hypothesis development. PiiMS is deployed as a World Wide Web-enabled system, allowing for integration of distributed workflow processes and open access to raw data for analysis by numerous laboratories. PiiMS currently contains data on shoot concentrations of P, Ca, K, Mg, Cu, Fe, Zn, Mn, Co, Ni, B, Se, Mo, Na, As, and Cd in over 60,000 shoot tissue samples of Arabidopsis (Arabidopsis thaliana), including ethyl methanesulfonate, fast-neutron and defined T-DNA mutants, and natural accession and populations of recombinant inbred lines from over 800 separate experiments, representing over 1,000,000 fully quantitative elemental concentrations. PiiMS is accessible at www.purdue.edu/dp/ionomics. PMID:17189337

  10. On-Chip Magnetic Platform for Single-Particle Manipulation with Integrated Electrical Feedback.

    Science.gov (United States)

    Monticelli, Marco; Torti, Andrea; Cantoni, Matteo; Petti, Daniela; Albisetti, Edoardo; Manzin, Alessandra; Guerriero, Erica; Sordan, Roman; Gervasoni, Giacomo; Carminati, Marco; Ferrari, Giorgio; Sampietro, Marco; Bertacco, Riccardo

    2016-02-17

    Methods for the manipulation of single magnetic particles have become very interesting, in particular for in vitro biological studies. Most of these studies require an external microscope to provide the operator with feedback for controlling the particle motion, thus preventing the use of magnetic particles in high-throughput experiments. In this paper, a simple and compact system with integrated electrical feedback is presented, implementing in the very same device both the manipulation and detection of the transit of single particles. The proposed platform is based on zig-zag shaped magnetic nanostructures, where transverse magnetic domain walls are pinned at the corners and attract magnetic particles in suspension. By applying suitable external magnetic fields, the domain walls move to the nearest corner, thus causing the step by step displacement of the particles along the nanostructure. The very same structure is also employed for detecting the bead transit. Indeed, the presence of the magnetic particle in suspension over the domain wall affects the depinning field required for its displacement. This characteristic field can be monitored through anisotropic magnetoresistance measurements, thus implementing an integrated electrical feedback of the bead transit. In particular, the individual manipulation and detection of single 1-μm sized beads is demonstrated. PMID:26707363

  11. An integrated microfluidic platform for negative selection and enrichment of cancer cells

    Science.gov (United States)

    Luo, Wen-Yi; Tsai, Sung-Chi; Hsieh, Kuangwen; Lee, Gwo-Bin

    2015-08-01

    Circulating tumor cells (CTCs), tumor cells that disseminate from primary tumors to the bloodstream, have recently emerged as promising indicators for cancer diagnosis and prognosis. However, the technical difficulties in isolating and detecting rare CTCs have limited the widespread applicability of this method to date. In this work, a new integrated microfluidic system integrating micromixers and micropumps capable of performing ‘negative selection and enrichment’ of CTCs was developed. By using anti-human CD45 antibodies-coated magnetic beads, leukocytes were effectively removed by applying an external magnetic force, leaving behind an enriched target cell population. The on-chip CTC recovery rate was experimentally found to be 70   ±   5% after a single round of negative selection and enrichment. Meanwhile, CD45 depletion efficiency was 83.99   ±   1.00% and could be improved to 99.84   ±   0.04% after three consecutive rounds of depletion. Notably, on-chip negative selection and enrichment was 58% faster and the repeated depletion could be processed automatically. These promising results suggested the developed microfluidic chip is potentiated for a standardized CTC isolation platform. Preliminary results of the current paper were presented at Micro TAS 2014, San Antonio, Texas, USA, October 26-30, 2014.

  12. Integrated III-V Photonic Crystal--Si waveguide platform with tailored optomechanical coupling.

    Science.gov (United States)

    Tsvirkun, Viktor; Surrente, Alessandro; Raineri, Fabrice; Beaudoin, Grégoire; Raj, Rama; Sagnes, Isabelle; Robert-Philip, Isabelle; Braive, Rémy

    2015-01-01

    Optomechanical systems, in which the vibrations of a mechanical resonator are coupled to an electromagnetic radiation, have permitted the investigation of a wealth of novel physical effects. To fully exploit these phenomena in realistic circuits and to achieve different functionalities on a single chip, the integration of optomechanical resonators is mandatory. Here, we propose a novel approach to heterogeneously integrate arrays of two-dimensional photonic crystal defect cavities on top of silicon-on-insulator waveguides. The optomechanical response of these devices is investigated and evidences an optomechanical coupling involving both dispersive and dissipative mechanisms. By controlling the optical coupling between the waveguide and the photonic crystal, we were able to vary and understand the relative strength of these couplings. This scalable platform allows for an unprecedented control on the optomechanical coupling mechanisms, with a potential benefit in cooling experiments, and for the development of multi-element optomechanical circuits in the framework of optomechanically-driven signal-processing applications. PMID:26567535

  13. A platform to integrate climate information and rural telemedicine in Malawi

    Science.gov (United States)

    Lowe, R.; Chadza, T.; Chirombo, J.; Fonda, C.; Muyepa, A.; Nkoloma, M.; Pietrosemoli, E.; Radicella, S. M.; Tompkins, A. M.; Zennaro, M.

    2012-04-01

    It is commonly accepted that climate plays a role in the transmission of many infectious diseases, particularly those transmitted by mosquitoes such as malaria, which is one of the most important causes of mortality and morbidity in developing countries. Due to time lags involved in the climate-disease transmission system, lagged observed climate variables could provide some predictive lead for forecasting disease epidemics. This lead time could be extended by using forecasts of the climate in disease prediction models. This project aims to implement a platform for the dissemination of climate-driven disease risk forecasts, using a telemedicine approach. A pilot project has been established in Malawi, where a 162 km wireless link has been installed, spanning from Blantyre City to remote health facilities in the district of Mangochi in the Southern region, bordering Lake Malawi. This long Wi-Fi technology allows rural health facilities to upload real-time disease cases as they occur to an online health information system (DHIS2); a national medical database repository administered by the Ministry of Health. This technology provides a real-time data logging system for disease incidence monitoring and facilitates the flow of information between local and national levels. This platform allows statistical and dynamical disease prediction models to be rapidly updated with real-time climate and epidemiological information. This permits health authorities to target timely interventions ahead of an imminent increase in malaria incidence. By integrating meteorological and health information systems in a statistical-dynamical prediction model, we show that a long-distance Wi-Fi link is a practical and inexpensive means to enable the rapid analysis of real-time information in order to target disease prevention and control measures and mobilise resources at the local level.

  14. A web platform for integrated surface water - groundwater modeling and data management

    Science.gov (United States)

    Fatkhutdinov, Aybulat; Stefan, Catalin; Junghanns, Ralf

    2016-04-01

    Model-based decision support systems are considered to be reliable and time-efficient tools for resources management in various hydrology related fields. However, searching and acquisition of the required data, preparation of the data sets for simulations as well as post-processing, visualization and publishing of the simulations results often requires significantly more work and time than performing the modeling itself. The purpose of the developed software is to combine data storage facilities, data processing instruments and modeling tools in a single platform which potentially can reduce time required for performing simulations, hence decision making. The system is developed within the INOWAS (Innovative Web Based Decision Support System for Water Sustainability under a Changing Climate) project. The platform integrates spatially distributed catchment scale rainfall - runoff, infiltration and groundwater flow models with data storage, processing and visualization tools. The concept is implemented in a form of a web-GIS application and is build based on free and open source components, including the PostgreSQL database management system, Python programming language for modeling purposes, Mapserver for visualization and publishing the data, Openlayers for building the user interface and others. Configuration of the system allows performing data input, storage, pre- and post-processing and visualization in a single not disturbed workflow. In addition, realization of the decision support system in the form of a web service provides an opportunity to easily retrieve and share data sets as well as results of simulations over the internet, which gives significant advantages for collaborative work on the projects and is able to significantly increase usability of the decision support system.

  15. Miniaturized devices towards an integrated lab-on-a-chip platform for DNA diagnostics

    Science.gov (United States)

    Kaprou, G.; Papadakis, G.; Kokkoris, G.; Papadopoulos, V.; Kefala, I.; Papageorgiou, D.; Gizeli, E.; Tserepi, A.

    2015-06-01

    Microfluidics is an emerging technology enabling the development of Lab-on-a-chip (LOC) systems for clinical diagnostics, drug discovery and screening, food safety and environmental analysis. LOC systems integrate and scale down one or several laboratory functions on a single chip of a few mm2 to cm2 in size, and account for many advantages on biochemical analyses, such as low sample and reagent consumption, low cost, reduced analysis time, portability and point-of-need compatibility. Currently, available nucleic acid diagnostic tests take advantage of Polymerase Chain Reaction (PCR) that allows exponential amplification of portions of nucleic acid sequences that can be used as indicators for the identification of various diseases. Here, we present a comparison between static chamber and continuous flow miniaturized PCR devices, in terms of energy consumption for devices fabricated on the same material stack, with identical sample volume and channel dimensions. The comparison is implemented by a computational study coupling heat transfer in both solid and fluid, mass conservation of species, and joule heating. Based on the conclusions of this study, we develop low-cost and fast DNA amplification devices for both PCR and isothermal amplification, and we implement them in the detection of mutations related to breast cancer. The devices are fabricated by mass production amenable technologies on printed circuit board (PCB) substrates, where copper facilitates the incorporation of on-chip microheaters, defining the thermal zones necessary for PCR or isothermal amplification methods.

  16. BiGG Models: A platform for integrating, standardizing and sharing genome-scale models.

    Science.gov (United States)

    King, Zachary A; Lu, Justin; Dräger, Andreas; Miller, Philip; Federowicz, Stephen; Lerman, Joshua A; Ebrahim, Ali; Palsson, Bernhard O; Lewis, Nathan E

    2016-01-01

    Genome-scale metabolic models are mathematically-structured knowledge bases that can be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can generate and test hypotheses when integrated with experimental data. To maximize the value of these models, centralized repositories of high-quality models must be established, models must adhere to established standards and model components must be linked to relevant databases. Tools for model visualization further enhance their utility. To meet these needs, we present BiGG Models (http://bigg.ucsd.edu), a completely redesigned Biochemical, Genetic and Genomic knowledge base. BiGG Models contains more than 75 high-quality, manually-curated genome-scale metabolic models. On the website, users can browse, search and visualize models. BiGG Models connects genome-scale models to genome annotations and external databases. Reaction and metabolite identifiers have been standardized across models to conform to community standards and enable rapid comparison across models. Furthermore, BiGG Models provides a comprehensive application programming interface for accessing BiGG Models with modeling and analysis tools. As a resource for highly curated, standardized and accessible models of metabolism, BiGG Models will facilitate diverse systems biology studies and support knowledge-based analysis of diverse experimental data. PMID:26476456

  17. SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum

    Directory of Open Access Journals (Sweden)

    Wang Zhi-Qin

    2008-06-01

    Full Text Available Abstract Background Schistosoma japonicum is one of the three major blood fluke species, the etiological agents of schistosomiasis which remains a serious public health problem with an estimated 200 million people infected in 76 countries. In recent years, enormous amounts of both transcriptomic and proteomic data of schistosomes have become available, providing information on gene expression profiles for developmental stages and tissues of S. japonicum. Here, we establish a public searchable database, termed SjTPdb, with integrated transcriptomic and proteomic data of S. japonicum, to enable more efficient access and utility of these data and to facilitate the study of schistosome biology, physiology and evolution. Description All the available ESTs, EST clusters, and the proteomic dataset of S. japonicum are deposited in SjTPdb. The core of the database is the 8,420 S. japonicum proteins translated from the EST clusters, which are well annotated for sequence similarity, structural features, functional ontology, genomic variations and expression patterns across developmental stages and tissues including the tegument and eggshell of this flatworm. The data can be queried by simple text search, BLAST search, search based on developmental stage of the life cycle, and an integrated search for more specific information. A PHP-based web interface allows users to browse and query SjTPdb, and moreover to switch to external databases by the following embedded links. Conclusion SjTPdb is the first schistosome database with detailed annotations for schistosome proteins. It is also the first integrated database of both transcriptome and proteome of S. japonicum, providing a comprehensive data resource and research platform to facilitate functional genomics of schistosome. SjTPdb is available from URL: http://function.chgc.sh.cn/sj-proteome/index.htm.

  18. Development of an Electronic Claim System Based on an Integrated Electronic Health Record Platform to Guarantee Interoperability

    OpenAIRE

    Kim, Hwa Sun; Cho, Hune; Lee, In Keun

    2011-01-01

    Objectives We design and develop an electronic claim system based on an integrated electronic health record (EHR) platform. This system is designed to be used for ambulatory care by office-based physicians in the United States. This is achieved by integrating various medical standard technologies for interoperability between heterogeneous information systems. Methods The developed system serves as a simple clinical data repository, it automatically fills out the Centers for Medicare and Medic...

  19. Effects of polyhalogenated hydrocarbons and related contaminants on common tern reproduction: Integration of (bio)chemical and ecological responses

    Energy Technology Data Exchange (ETDEWEB)

    Murk, A.J. [Agricultural Univ., Wageningen (Netherlands); Boudewijn, T.J.; Dirksen, S. [Bureau Waardenburg, Culemborg (Netherlands); Bosveld, A.T.C. [Univ. of Utrecht (Netherlands); Rossaert, G.; Ysebaert, T.; Meire, P. [Inst. for Nature Management, Hasselt (Belgium); Meininger, P.L.

    1995-12-31

    An integrated ecotoxicological study was made to establish the possible effects of polyhalogenated hydrocarbons (PHAHs) on common tern (Stema hirundo) reproduction. In eight Dutch or Belgian colonies, breeding biology and food choice were determined. In all colonies 15 second eggs from three-egg clutches were collected for artificial incubation and (bio)chemical analysis. Results from these analyses were combined with biological data from the remaining eggs of the clutches. A relationship was found between yolksac mono-ortho PCB levels and main food species (fish or insects) of the adult terns before egg-laying. Colony average breeding data differed only slightly, and were difficult to relate to PHAH levels. When the colonies were grouped after yolksac PHAH-patterns and main food species, significant differences in average egg laying date, egg laying period, incubation period, egg volume and chick weight could be related to differences in yolksac PHAH and retinoid levels, and hepatic EROD activity. The data from all colonies also were used as one dataset and correlated with the (bio)chemical parameters. In summary there were significant correlations or clear trends between yolksac PHAHs or hepatic EROD-activity and prolonged egg laying and incubation period, and smaller eggs and chicks. Lower yolksac retinoid and plasma thyroid hormone levels, and a higher ratio of plasma retinol over yolksac retinoids correlated with longer egg laying and incubation periods, and smaller chicks and eggs (only with thyroid hormone).

  20. LabKey Server: An open source platform for scientific data integration, analysis and collaboration

    Directory of Open Access Journals (Sweden)

    Lum Karl

    2011-03-01

    Full Text Available Abstract Background Broad-based collaborations are becoming increasingly common among disease researchers. For example, the Global HIV Enterprise has united cross-disciplinary consortia to speed progress towards HIV vaccines through coordinated research across the boundaries of institutions, continents and specialties. New, end-to-end software tools for data and specimen management are necessary to achieve the ambitious goals of such alliances. These tools must enable researchers to organize and integrate heterogeneous data early in the discovery process, standardize processes, gain new insights into pooled data and collaborate securely. Results To meet these needs, we enhanced the LabKey Server platform, formerly known as CPAS. This freely available, open source software is maintained by professional engineers who use commercially proven practices for software development and maintenance. Recent enhancements support: (i Submitting specimens requests across collaborating organizations (ii Graphically defining new experimental data types, metadata and wizards for data collection (iii Transitioning experimental results from a multiplicity of spreadsheets to custom tables in a shared database (iv Securely organizing, integrating, analyzing, visualizing and sharing diverse data types, from clinical records to specimens to complex assays (v Interacting dynamically with external data sources (vi Tracking study participants and cohorts over time (vii Developing custom interfaces using client libraries (viii Authoring custom visualizations in a built-in R scripting environment. Diverse research organizations have adopted and adapted LabKey Server, including consortia within the Global HIV Enterprise. Atlas is an installation of LabKey Server that has been tailored to serve these consortia. It is in production use and demonstrates the core capabilities of LabKey Server. Atlas now has over 2,800 active user accounts originating from approximately 36

  1. Supervised Regularized Canonical Correlation Analysis: integrating histologic and proteomic measurements for predicting biochemical recurrence following prostate surgery

    Directory of Open Access Journals (Sweden)

    Golugula Abhishek

    2011-12-01

    Full Text Available Abstract Background Multimodal data, especially imaging and non-imaging data, is being routinely acquired in the context of disease diagnostics; however, computational challenges have limited the ability to quantitatively integrate imaging and non-imaging data channels with different dimensionalities and scales. To the best of our knowledge relatively few attempts have been made to quantitatively fuse such data to construct classifiers and none have attempted to quantitatively combine histology (imaging and proteomic (non-imaging measurements for making diagnostic and prognostic predictions. The objective of this work is to create a common subspace to simultaneously accommodate both the imaging and non-imaging data (and hence data corresponding to different scales and dimensionalities, called a metaspace. This metaspace can be used to build a meta-classifier that produces better classification results than a classifier that is based on a single modality alone. Canonical Correlation Analysis (CCA and Regularized CCA (RCCA are statistical techniques that extract correlations between two modes of data to construct a homogeneous, uniform representation of heterogeneous data channels. In this paper, we present a novel modification to CCA and RCCA, Supervised Regularized Canonical Correlation Analysis (SRCCA, that (1 enables the quantitative integration of data from multiple modalities using a feature selection scheme, (2 is regularized, and (3 is computationally cheap. We leverage this SRCCA framework towards the fusion of proteomic and histologic image signatures for identifying prostate cancer patients at the risk of 5 year biochemical recurrence following radical prostatectomy. Results A cohort of 19 grade, stage matched prostate cancer patients, all of whom had radical prostatectomy, including 10 of whom had biochemical recurrence within 5 years of surgery and 9 of whom did not, were considered in this study. The aim was to construct a lower

  2. The VIPER project (Visualization Integration Platform for Exploration Research): a biologically inspired autonomous reconfigurable robotic platform for diverse unstructured environments

    Science.gov (United States)

    Schubert, Oliver J.; Tolle, Charles R.

    2004-09-01

    Over the last decade the world has seen numerous autonomous vehicle programs. Wheels and track designs are the basis for many of these vehicles. This is primarily due to four main reasons: a vast preexisting knowledge base for these designs, energy efficiency of power sources, scalability of actuators, and the lack of control systems technologies for handling alternate highly complex distributed systems. Though large efforts seek to improve the mobility of these vehicles, many limitations still exist for these systems within unstructured environments, e.g. limited mobility within industrial and nuclear accident sites where existing plant configurations have been extensively changed. These unstructured operational environments include missions for exploration, reconnaissance, and emergency recovery of objects within reconfigured or collapsed structures, e.g. bombed buildings. More importantly, these environments present a clear and present danger for direct human interactions during the initial phases of recovery operations. Clearly, the current classes of autonomous vehicles are incapable of performing in these environments. Thus the next generation of designs must include highly reconfigurable and flexible autonomous robotic platforms. This new breed of autonomous vehicles will be both highly flexible and environmentally adaptable. Presented in this paper is one of the most successful designs from nature, the snake-eel-worm (SEW). This design implements shape memory alloy (SMA) actuators which allow for scaling of the robotic SEW designs from sub-micron scale to heavy industrial implementations without major conceptual redesigns as required in traditional hydraulic, pneumatic, or motor driven systems. Autonomous vehicles based on the SEW design posses the ability to easily move between air based environments and fluid based environments with limited or no reconfiguration. Under a SEW designed vehicle, one not only achieves vastly improved maneuverability within a

  3. IMPACT_S: integrated multiprogram platform to analyze and combine tests of selection.

    Directory of Open Access Journals (Sweden)

    Emanuel Maldonado

    Full Text Available Among the major goals of research in evolutionary biology are the identification of genes targeted by natural selection and understanding how various regimes of evolution affect the fitness of an organism. In particular, adaptive evolution enables organisms to adapt to changing ecological factors such as diet, temperature, habitat, predatory pressures and prey abundance. An integrative approach is crucial for the identification of non-synonymous mutations that introduce radical changes in protein biochemistry and thus in turn influence the structure and function of proteins. Performing such analyses manually is often a time-consuming process, due to the large number of statistical files generated from multiple approaches, especially when assessing numerous taxa and/or large datasets. We present IMPACT_S, an easy-to-use Graphical User Interface (GUI software, which rapidly and effectively integrates, filters and combines results from three widely used programs for assessing the influence of selection: Codeml (PAML package, Datamonkey and TreeSAAP. It enables the identification and tabulation of sites detected by these programs as evolving under the influence of positive, neutral and/or negative selection in protein-coding genes. IMPACT_S further facilitates the automatic mapping of these sites onto the three-dimensional structures of proteins. Other useful tools incorporated in IMPACT_S include Jmol, Archaeopteryx, Gnuplot, PhyML, a built-in Swiss-Model interface and a PDB downloader. The relevance and functionality of IMPACT_S is shown through a case study on the toxicoferan-reptilian Cysteine-rich Secretory Proteins (CRiSPs. IMPACT_S is a platform-independent software released under GPLv3 license, freely available online from http://impact-s.sourceforge.net.

  4. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yafei [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Brott, David [Patient Safety, AstraZeneca R and D Wilmington, DE 19850 (United States); Luo, Wenli [Discovery Statistics, AstraZeneca R and D Waltham, MA 02451 (United States); Gangl, Eric [DMPK, AstraZeneca R and D Waltham, MA 02451 (United States); Kamendi, Harriet; Barthlow, Herbert; Lengel, David; Fikes, James; Kinter, Lewis [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States); Valentin, Jean-Pierre [Global Safety Assessment, AstraZeneca R and D Alderley Park, Macclesfield, SK10 4TG (United Kingdom); Bialecki, Russell, E-mail: russell.bialecki@astrazeneca.com [Global Safety Assessment, AstraZeneca R and D Waltham, MA 02451 (United States)

    2013-05-01

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development.

  5. Assessment of cisplatin-induced kidney injury using an integrated rodent platform

    International Nuclear Information System (INIS)

    Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of overall kidney function and changes are delayed with respect to onset of nephron injury. Our aim was to investigate whether early changes in new urinary DIKI biomarkers predict plasma Cr, BUN, renal hemodynamic and kidney morphological changes associated with kidney injury following a single dose of cisplatin (CDDP) using an integrated platform in rodent. Conscious surgically prepared male Han Wistar rats were given a single intraperitoneal dose of CDDP (15 mg/kg). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), urinalysis, DIKI biomarkers, CDDP pharmacokinetics, blood pressures, heart rate, body temperature and electroencephalogram (EEG) were measured in the same vehicle- or CDDP-treated animals over 72 h. Plasma chemistry (including Cr and BUN) and renal tissues were examined at study termination. Cisplatin caused progressive reductions of GFR, ERPF, heart rate and body temperature from day 1 (0–24 h). DIKI biomarkers including alpha-glutathione S-transferase (α-GST) significantly increased as early as 6 h post-dose, which preceded significant declines of GFR and ERPF (24 h), increased plasma Cr and BUN (72 h), and associated with renal acute tubular necrosis at 72 h post-dose. The present study adds to the current understanding of CDDP action by demonstrating that early increases in urinary excretion of α-GST predict DIKI risk following acute exposure to CDDP in rats, before changes in traditional DIKI markers are evident. - Highlights: ► CDDP causes direct damage to kidneys without affecting EEG or CVS function. ► α-GST and albumin detect DIKI earlier when compared with traditional indices. ► Integrated “cardiovascular-EEG-renal” model to better understand DIKI mechanisms ► Promotes 3R's principles in drug discovery and development

  6. An Integrated Approach to Fatigue Life Prediction of Whole System for Offshore Platforms

    Institute of Scientific and Technical Information of China (English)

    方华灿; 段梦兰; 许发彦; 吴永宁; 樊晓东

    2001-01-01

    The failure of one or even more components usually does not lead to the collapse of the whole structure. Most of theanalysis of fatigue is centered on only a single component which the researchers are interested in or much attentionshould be paid to. However, the collapse of a structure is the result of failure of a series of components in a specific orderor path. This paper proposes an integrated approach to fatigue life prediction of whole structural system for offshoreplatforms, mainly describing the basic principles and prediction method. A method is presented for determining the fail-ure path of the whole structure system and calculating the fatigue life in the determined failure path. The correspondingfinal collapse criteria for the whole structure system are discussed. A simple method of equivalent fatigue stress range cal-culation and a mathematical model of structural component fatigue life estimation in consideration of sea wave and seaice loads are provided. As an application of the proposed approach, a fixed production platform Bohai No. 8 is chosenfor the predication of fatigue life of the whole structure system by means of the software OSFAC developed based on thepresent methods.

  7. An integrated micro-manipulation and biosensing platform built in glass-based LTPS TFT technology

    International Nuclear Information System (INIS)

    The glass-based low-temperature polycrystalline-silicon (LTPS) thin-film transistor (TFT) process, widely known for making liquid crystal displays, is utilized in this work to realize a fully integrated, microbead-based micro-manipulation and biosensing platform. The operation utilizes arrays of microelectrodes made of transparent iridium tin oxide (ITO) to move the immobilized polystyrene microbeads to the sensor surface by dielectrophoresis (DEP). Detection of remaining microbeads after a specific antigen/antibody reaction is accomplished by photo-detectors under the transparent electrodes. It was found that microbeads can be driven successfully by the 30 × 30 µm2 microelectrodes separated by 10 µm with no more than 6 Vp–p, which is compatible with the operating range of thin-film transistors. Microbeads immobilized with antimouse immunoglobulin (IgG) and prostate-specific antigen (PSA) antibody were successfully detected after specific binding, illustrating the potential of LTPS TFT microarrays for more versatile biosensing applications. (paper)

  8. A Semantic Big Data Platform for Integrating Heterogeneous Wearable Data in Healthcare.

    Science.gov (United States)

    Mezghani, Emna; Exposito, Ernesto; Drira, Khalil; Da Silveira, Marcos; Pruski, Cédric

    2015-12-01

    Advances supported by emerging wearable technologies in healthcare promise patients a provision of high quality of care. Wearable computing systems represent one of the most thrust areas used to transform traditional healthcare systems into active systems able to continuously monitor and control the patients' health in order to manage their care at an early stage. However, their proliferation creates challenges related to data management and integration. The diversity and variety of wearable data related to healthcare, their huge volume and their distribution make data processing and analytics more difficult. In this paper, we propose a generic semantic big data architecture based on the "Knowledge as a Service" approach to cope with heterogeneity and scalability challenges. Our main contribution focuses on enriching the NIST Big Data model with semantics in order to smartly understand the collected data, and generate more accurate and valuable information by correlating scattered medical data stemming from multiple wearable devices or/and from other distributed data sources. We have implemented and evaluated a Wearable KaaS platform to smartly manage heterogeneous data coming from wearable devices in order to assist the physicians in supervising the patient health evolution and keep the patient up-to-date about his/her status. PMID:26490143

  9. An Architecture for the Integration of Clinical Data from a PEHR in a Regional Research Platform.

    Science.gov (United States)

    Schreiweis, Björn; Bronsch, Tobias; Stein, Katharina E; Nöst, Stefan; Aguduri, Lakshmi S; Brandner, Antje; Pensold, Peter; Weiss, Nicolas; Yüksekogul, Nilay; Bergh, Björn; Heinze, Oliver

    2016-01-01

    Making clinical information available for research is not only relevant for healthcare institutions, but also for regional EHRs, as cross-sectorial information can be made accessible. In the INFOPAT (INFOrmation technology for PATient-oriented health care in the Rhine-Neckar metropolitan region) project we are thus implementing both, a regional personal cross-enterprise electronic health record (PEHR) and a regional research platform (RRP) based on information from the PEHR. IHE profiles are implemented to achieve interoperability between healthcare institutions electronic medical records (EMR) and PEHR on the one hand, as well as PEHR and RRP on the other hand. The use case for the RRP is cross-sectorial quality assessment and improvement for colorectal cancer based on a quality indicator (QI) approach including patients' perspectives. For semantic interoperability the responses are transferred in the form of HL7 CDA L2 documents. The resulting architecture for a RRP shows that implementing a PEHR in combination with a RRP based on international communication standards is possible. Also IHE XDS can be used for integration of patient care and biomedical research infrastructures. PMID:27577386

  10. An integrated telemedicine platform for the assessment of affective physiological states

    Directory of Open Access Journals (Sweden)

    Ganiatsas George

    2006-08-01

    Full Text Available Abstract AUBADE is an integrated platform built for the affective assessment of individuals. The system performs evaluation of the emotional state by classifying vectors of features extracted from: facial Electromyogram, Respiration, Electrodermal Activity and Electrocardiogram. The AUBADE system consists of: (a a multisensorial wearable, (b a data acquisition and wireless communication module, (c a feature extraction module, (d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model; whereas the end-user will be able to view the facial expression of the subject in real time, (e an intelligent emotion recognition module, and (f the AUBADE databases where the acquired signals along with the subject's animation videos are saved. The system is designed to be applied to human subjects operating under extreme stress conditions, in particular car racing drivers, and also to patients suffering from neurological and psychological disorders. AUBADE's classification accuracy into five predefined emotional classes (high stress, low stress, disappointment, euphoria and neutral face is 86.0%. The pilot system applications and components are being tested and evaluated on Maserati's car. racing drivers.

  11. Integrated Alignment and Inspection Platform for High Precision Optical Continuous Images

    OpenAIRE

    Chuen-Horng Lin; Muh-Don Hsiao; Chun-Chi Lo

    2014-01-01

    This platform is mainly intended to be used as a facility for high precision optical continuous images. Then, with a fixed pattern being selected, this platform can quickly search, with resistance to variation, the mark that corresponds to the pattern in order to achieve the alignment and inspection target. Since the pattern is a minute component with multiple shapes and unstable features, this platform can automatically acquire it through the system or select it by user. The targets searched...

  12. Sinian-Cambrian stratigraphic framework for shallow- to deep-water environments of the Yangtze Platform: an integrated approach

    Institute of Scientific and Technical Information of China (English)

    ZHU Maoyan; ZHANG Junming; Michael STEINER; YANG Aihua; LI Guoxiang; Bernd D. ERDTMANN

    2003-01-01

    The Sinian (Terminal Proterozoic) and Early Cambrian shallow- to deep-water sequences of the Yangtze Platform were investigated. Based on integrated lithostratigraphic, biostratigraphic, and other approaches, the shallow-water sequence from the base of the Sinian (base of the Doushantuo Formation) to the top of the Qiongzhusian (top of the Yu'anshan Formation) was subdivided into 12 stratigraphic intervals. These 12 intervals were applied in turn to the subdivision and correlation of the sequences present in various facies of the Yangtze Platform. The high-resolution stratigraphic framework here developed can serve as a time frame for ongoing multidisciplinary analyses of the "Cambrian explosion".

  13. The tsunami service bus, an integration platform for heterogeneous sensor systems

    Science.gov (United States)

    Haener, R.; Waechter, J.; Kriegel, U.; Fleischer, J.; Mueller, S.

    2009-04-01

    components remain unchanged, components can be maintained and evolved independently on each other and service functionality as a whole can be reused. In GITEWS the functional integration pattern was adopted by applying the principles of an Enterprise Service Bus (ESB) as a backbone. Four services provided by the so called Tsunami Service Bus (TSB) which are essential for early warning systems are realized compliant to services specified within the Sensor Web Enablement (SWE) initiative of the Open Geospatial Consortium (OGC). 3. ARCHITECTURE The integration platform was developed to access proprietary, heterogeneous sensor data and to provide them in a uniform manner for further use. Its core, the TSB provides both a messaging-backbone and -interfaces on the basis of a Java Messaging Service (JMS). The logical architecture of GITEWS consists of four independent layers: • A resource layer where physical or virtual sensors as well as data or model storages provide relevant measurement-, event- and analysis-data: Utilizable for the TSB are any kind of data. In addition to sensors databases, model data and processing applications are adopted. SWE specifies encoding both to access and to describe these data in a comprehensive way: 1. Sensor Model Language (SensorML): Standardized description of sensors and sensor data 2. Observations and Measurements (O&M): Model and encoding of sensor measurements • A service layer to collect and conduct data from heterogeneous and proprietary resources and provide them via standardized interfaces: The TSB enables interaction with sensors via the following services: 1. Sensor Observation Service (SOS): Standardized access to sensor data 2. Sensor Planning Service (SPS): Controlling of sensors and sensor networks 3. Sensor Alert Service (SAS): Active sending of data if defined events occur 4. Web Notification Service (WNS): Conduction of asynchronous dialogues between services • An orchestration layer where atomic services are composed and

  14. Integration of HIV in child survival platforms: a novel programmatic pathway towards the 90–90–90 targets

    Directory of Open Access Journals (Sweden)

    Dick D Chamla

    2015-12-01

    Full Text Available Introduction: Integration of HIV into child survival platforms is an evolving territory with multiple connotations. Most literature on integration of HIV into other health services focuses on adults; however promising practices for children are emerging. These include the Double Dividend (DD framework, a new programming approach with dual goal of improving paediatric HIV care and child survival. In this commentary, the authors discuss why integrating HIV testing, treatment and care into child survival platforms is important, as well as its potential to advance progress towards global targets that call for, by 2020, 90% of children living with HIV to know their status, 90% of those diagnosed to be on treatment and 90% of those on treatment to be virally suppressed (90–90–90. Discussion: Integration is critical in improving health outcomes and efficiency gains. In children, integration of HIV in programmes such as immunization and nutrition has been associated with an increased uptake of HIV infant testing. Integration is increasingly recognized as a case-finding strategy for children missed from prevention of mother-to-child transmission programmes and as a platform for diffusing emerging technologies such as point-of-care diagnostics. These support progress towards the 90–90–90 targets by providing a pathway for early identification of HIV-infected children with co-morbidities, prompt initiation of treatment and improved survival. There are various promising practices that have demonstrated HIV outcomes; however, few have documented the benefits of integration on child survival interventions. The DD framework is well positioned to address the bidirectional impacts for both programmes. Conclusions: Integration provides an important programmatic pathway for accelerated progress towards the 90–90–90 targets. Despite this encouraging information, there are still challenges to be addressed in order to maximize the benefits of integration.

  15. Biochemical parameters in Tubifex tubifex as an integral part of complex sediment toxicity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Smutna, M.; Hilscherova, K.; Paskova, V. [Masaryk Univ., Brno (CZ). RECETOX (Research Centre for Environmental Chemistry and Ecotoxicology); Marsalek, B [Czech Academy of Science, Brno (Czech Republic). Centre for Cyanobacteria and their Toxins

    2008-06-15

    Background, aim, and scope Restoration of lakes and reservoirs with extensive cyanobacterial water bloom often requires evaluation of the sediment quality. Next to the chemical analysis of known pollutants, sediment bioassays should be employed to assess toxicity of the present contaminants and to make predictions of associated risk. Brno reservoir in the Czech Republic is a typical example of water bodies with long-term problems concerning cyanobacterial water blooms. Comprehensive assessment of reservoir sediment quality was conducted since successful reservoir restoration might require sediment removal. An important part of this survey focused on an examination of the utility of Tubifex tubifex and its sublethal biochemical markers for the assessment of direct sediment toxicity. Materials and methods This complex study included chemical analysis of contaminants (heavy metals, organic pollutants), ecotoxicity testing of sediment elutriates (tests with Daphnia magna, Pseudomonas putida, Sinapis alba, Scenedesmus subspicatus), and other parameters. We have tested in more detail the applicability of T. tubifex as a test organism for direct evaluation of contact sediment toxicity. Survival tests after 14 days of exposure were complemented by an assessment of parameters serving as biomarkers for sublethal effects [such as total glutathione content (GSH), activities of the enzymes glutathione transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GR)]. The data matrix was subjected to multivariate analysis to interpret relationships between different parameters and possible differences among locations. Results The multivariate statistical techniques helped to clearly identify the more contaminated upstream sites and separate them from the less contaminated and reference samples. The data document closer relationships of the detected sediment contamination with results of direct sediment exposure in the T. tubifex test regarding mortality but namely

  16. A big data geospatial analytics platform - Physical Analytics Integrated Repository and Services (PAIRS)

    Science.gov (United States)

    Hamann, H.; Jimenez Marianno, F.; Klein, L.; Albrecht, C.; Freitag, M.; Hinds, N.; Lu, S.

    2015-12-01

    A big data geospatial analytics platform:Physical Analytics Information Repository and Services (PAIRS)Fernando Marianno, Levente Klein, Siyuan Lu, Conrad Albrecht, Marcus Freitag, Nigel Hinds, Hendrik HamannIBM TJ Watson Research Center, Yorktown Heights, NY 10598A major challenge in leveraging big geospatial data sets is the ability to quickly integrate multiple data sources into physical and statistical models and be run these models in real time. A geospatial data platform called Physical Analytics Information and Services (PAIRS) is developed on top of open source hardware and software stack to manage Terabyte of data. A new data interpolation and re gridding is implemented where any geospatial data layers can be associated with a set of global grid where the grid resolutions is doubling for consecutive layers. Each pixel on the PAIRS grid have an index that is a combination of locations and time stamp. The indexing allow quick access to data sets that are part of a global data layers and allowing to retrieve only the data of interest. PAIRS takes advantages of parallel processing framework (Hadoop) in a cloud environment to digest, curate, and analyze the data sets while being very robust and stable. The data is stored on a distributed no-SQL database (Hbase) across multiple server, data upload and retrieval is parallelized where the original analytics task is broken up is smaller areas/volume, analyzed independently, and then reassembled for the original geographical area. The differentiating aspect of PAIRS is the ability to accelerate model development across large geographical regions and spatial resolution ranging from 0.1 m up to hundreds of kilometer. System performance is benchmarked on real time automated data ingestion and retrieval of Modis and Landsat data layers. The data layers are curated for sensor error, verified for correctness, and analyzed statistically to detect local anomalies. Multi-layer query enable PAIRS to filter different data

  17. Integrated micro-biochemical approach for phytoremediation of cadmium and zinc contaminated soils.

    Science.gov (United States)

    Mani, Dinesh; Kumar, Chitranjan; Patel, Niraj Kumar

    2015-01-01

    The integrated potential of oilcake manure (OM), elemental sulphur (S(0)), Glomus fasciculatum and Pseudomonas putida by growing Helianthus annuus L for phytoremediation of cadmium and zinc contaminated soils was investigated under pot experiment. The integrated treatment (2.5 g kg(-1) OM, 0.8 g kg(-1) S(0) and co-inoculation with G. fasciculatum and P. putida promoted the dry biomass of the plant. The treatment was feasible for enhanced cadmium accumulation up to 6.56 and 5.25 mg kg(-1) and zinc accumulation up to 45.46 and 32.56 mg kg(-1) in root and shoot, respectively, which caused maximum remediation efficiency (0.73 percent and 0.25 percent) and bioaccumulation factor (2.39 and 0.83) for Cd and Zn, respectively showing feasible uptake (in mg kg(-1) dry biomass) of Cd (5.55) and Zn (35.51) at the contaminated site. Thus, authors conclude to integrate oilcake manure, S(0) and microbial co-inoculation for enhanced clean-up of cadmium and zinc-contaminated soils. PMID:25450919

  18. End-to-end integrated security and performance analysis on the DEGAS Choreographer platform

    DEFF Research Database (Denmark)

    Buchholtz, Mikael; Gilmore, Stephen; Haenel, Valentin;

    2005-01-01

    We present a software tool platform which facilitates security and performance analysis of systems which starts and ends with UML model descriptions. A UML project is presented to the platform for analysis, formal content is extracted in the form of process calculi descriptions, analysed with the...... report on the experience of industrial users who have applied Choreographer in their development work....

  19. Lab-on-a-chip systems with integrated optics for biochemical applications

    DEFF Research Database (Denmark)

    Mogensen, Klaus Bo; Gustafsson, O; Nunes, Pedro;

    2008-01-01

    microfabricated pillars, while the optical part consists of ultraviolet transparent planar waveguides for absorbance detection in the plane of the chip and fiber couplers for easy connection to an external light source and a photodetector. Electrochromatographic separations have been performed using hydrophobic......Two different applications that take advantage of integrated planar waveguides will be shown. The first example is a silicon chips for capillary electrochromatography (CEC), where the fluidic part contains electrically insulated channels with an injection cross and a chromatography column of...

  20. Integrated platform with a combination of online digestion and (18)O labeling for proteome quantification via an immobilized trypsin microreactor.

    Science.gov (United States)

    Zhang, Shen; Yuan, Huiming; Zhao, Baofeng; Zhou, Yuan; Jiang, Hao; Zhang, Lihua; Liang, Zhen; Zhang, Yukui

    2015-08-01

    A novel automated integrated platform for quantitative proteome analysis was established with a combination of online digestion of proteins and in situ(18)O labeling by an immobilized enzyme reactor (IMER); digests were captured and desalted by a C18 trap column, and peptides were analyzed by nanoRPLC-ESI-MS/MS. Bovine serum albumin (BSA) was used to evaluate the performance of the developed platform. Compared with traditional offline methods, not only the digestion and labeling time was shortened from 36 h to just 1 h, but also the labeling efficiency was improved from 95% to 99%. Furthermore, the back-exchange from (18)O to (16)O could also be efficiently avoided by the use of IMER. The platform was further evaluated by the quantitative analysis of 100 ng (18)O and (16)O online labeled yeast sample with a mixing ratio of 1 : 1, and the results showed significantly improved sensitivity and reproducibility, as well as improved quantitative accuracy than offline method. With these advantages, the integrated platform was finally applied to the quantitative profiling of 100 ng proteins extracted from two mouse hepatocarcinoma ascites syngeneic cell lines with high and low lymph node metastases rates, and ten differentially expressed proteins were successfully found, most of which were related to tumorigenesis and tumor metastasis. All these results demonstrate that the developed integrated platform can provide a new way for high efficiency (18)O labeling and the quantitative analysis of trace amounts of sample with high accuracy and high reproducibility. PMID:26063120

  1. Cantilever-based bio-chemical sensor integrated in a microliquid handling system

    DEFF Research Database (Denmark)

    Thaysen, Jacob; Marie, Rodolphe; Boisen, Anja

    2001-01-01

    The cantilevers have integrated piezoresistive readout which, compared to optical readout, enables simple measurements on even non-transparent liquids, such as blood. First, we introduce a simple theory for using piezoresistive cantilevers as surface stress sensors. Then, the sensor fabrication...... based on conventional microfabrication is described and the sensor characterization is discussed. During the characterization we found a stress sensitivity of (ΔR/R)=4.6:10 -4 (N/m)-1 and a minimum detectable surface stress change of 2.6 mN/m. Aqua regia etch of gold on top of the cantilevers has been...... monitored, and immobilization of single-stranded thiol modified DNA-oligos has been detected by the sensor. Finally, it is demonstrated that it is possible to analyze two samples simultaneously by utilizing the laminar flow in the microliquid handling system....

  2. Pragmatic Metadata Management for Integration into Multiple Spatial Data Infrastructure Systems and Platforms

    Science.gov (United States)

    Benedict, K. K.; Scott, S.

    2013-12-01

    While there has been a convergence towards a limited number of standards for representing knowledge (metadata) about geospatial (and other) data objects and collections, there exist a variety of community conventions around the specific use of those standards and within specific data discovery and access systems. This combination of limited (but multiple) standards and conventions creates a challenge for system developers that aspire to participate in multiple data infrastrucutres, each of which may use a different combination of standards and conventions. While Extensible Markup Language (XML) is a shared standard for encoding most metadata, traditional direct XML transformations (XSLT) from one standard to another often result in an imperfect transfer of information due to incomplete mapping from one standard's content model to another. This paper presents the work at the University of New Mexico's Earth Data Analysis Center (EDAC) in which a unified data and metadata management system has been developed in support of the storage, discovery and access of heterogeneous data products. This system, the Geographic Storage, Transformation and Retrieval Engine (GSTORE) platform has adopted a polyglot database model in which a combination of relational and document-based databases are used to store both data and metadata, with some metadata stored in a custom XML schema designed as a superset of the requirements for multiple target metadata standards: ISO 19115-2/19139/19110/19119, FGCD CSDGM (both with and without remote sensing extensions) and Dublin Core. Metadata stored within this schema is complemented by additional service, format and publisher information that is dynamically "injected" into produced metadata documents when they are requested from the system. While mapping from the underlying common metadata schema is relatively straightforward, the generation of valid metadata within each target standard is necessary but not sufficient for integration into

  3. The open source GIS, an ideal framework for the development of an integrated modelling platform devoted to sustainable urban planning

    OpenAIRE

    Hegron, Gérard; Bocher, Erwan; Petit, Gwendall

    2012-01-01

    Sustainable urban planning needs the development of a systemic approach involving environmental, social and economic dimensions where the evaluation of public policies is of paramount importance for decision making. This approach requires to set up an integrated modelling platform for the computation of indicators and spatial analysis tools at different scales. In this presentation we will demonstrate first that the GIS is an ideal framework to fulfil this objective, second, that the open sou...

  4. Identification and Confirmation of biomarkers using an integrated platform for quantitative analysis of glycoproteins and their glycosylations

    OpenAIRE

    Liu, Yashu; He, Jintang; Li, Chen; Benitez, Ricardo; Fu, Sherry; Marrero, Jorge; Lubman, David M

    2010-01-01

    Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. However, accurate diagnosis can be difficult as most of the patients who develop this tumor have symptoms similar to those caused by longstanding liver disease. Herein we developed an integrated platform to discover the glycoprotein biomarkers in early HCC. At first, lectin arrays were applied to investigate the differences in glycan structures on serum glycoproteins from HCC and cirrhosis patients. The in...

  5. Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

    OpenAIRE

    Medina, Ignacio; Carbonell, José; Pulido, Luis; Madeira, Sara C; Goetz, Stefan; Conesa, Ana; Tárraga, Joaquín; Pascual-Montano, Alberto; Nogales-Cadenas, Ruben; Santoyo, Javier; García, Francisco; Marbà, Martina; Montaner, David; Dopazo, Joaquín

    2010-01-01

    Babelomics is a response to the growing necessity of integrating and analyzing different types of genomic data in an environment that allows an easy functional interpretation of the results. Babelomics includes a complete suite of methods for the analysis of gene expression data that include normalization (covering most commercial platforms), pre-processing, differential gene expression (case-controls, multiclass, survival or continuous values), predictors, clustering; large-scale genotyping ...

  6. Integration of COMPSs programming model with a new generation of Object Storage Platforms

    OpenAIRE

    Díaz Suárez, Carlos

    2016-01-01

    This master thesis shows that the marriage of Programming Models and the new emarging Object Storage Platforms is a powerful framework to deal with the Exascale and Big-Data issues in scientific applications for the next 2020 horizon.

  7. Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

    Science.gov (United States)

    Riahi, Reza; Shaegh, Seyed Ali Mousavi; Ghaderi, Masoumeh; Zhang, Yu Shrike; Shin, Su Ryon; Aleman, Julio; Massa, Solange; Kim, Duckjin; Dokmeci, Mehmet Remzi; Khademhosseini, Ali

    2016-04-01

    There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such as ELISA and mass spectroscopy cannot satisfy the needs of continual monitoring as they are labor-intensive and not easily integrable with low-volume bioreactors. This paper reports on the development of an automated microfluidic bead-based electrochemical immunosensor for in-line measurement of cell-secreted biomarkers. For the operation of the multi-use immunosensor, disposable magnetic microbeads were used to immobilize biomarker-recognition molecules. Microvalves were further integrated in the microfluidic immunosensor chip to achieve programmable operations of the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing. The platform allowed convenient integration of the immunosensor with liver-on-chips to carry out continual quantification of biomarkers secreted from hepatocytes. Transferrin and albumin productions were monitored during a 5-day hepatotoxicity assessment in which human primary hepatocytes cultured in the bioreactor were treated with acetaminophen. Taken together, our unique microfluidic immunosensor provides a new platform for in-line detection of biomarkers in low volumes and long-term in vitro assessments of cellular functions in microfluidic bioreactors and organs-on-chips.

  8. Flight Control System Simulation Platform for UAV Based on Integrating Simulink With Stateflow

    OpenAIRE

    Xiao Qiangui; Ju Xiao; Hu Shousong; Gao Yanhui

    2012-01-01

    Aiming at rapidly analyzing and validating control strategy, control law and flight mode of the Unmanned Aerial Vehicle (UAV), a digital simulation test platform for flight control system (FCS) of UAV is presented in this paper. The platform is built on principles of hierarchy and modularity, its core is composed of flight mode management and control module, and the two components are implemented by using Matlab/Stateflow and embedded Simulink Function respectively. Simulation test for a cert...

  9. Development and application of knowledge-based subject group integration platforms:A case study of Shanghai Institute of Ceramics,CAS

    Institute of Scientific and Technical Information of China (English)

    Yu; LIU; Jian; FU; Huijun; ZHENG; Hao; CHEN; Zhiping; YANG

    2014-01-01

    Purpose:According to the different requirements of research group users,we established the knowledge-based subject group integration platforms of Shanghai Institute of Ceramics,the Chinese Academy of Sciences(abbreviated as SIC CAS hereinafter),which were designed and constructed to better meet the needs of CAS research groups for their development,collaboration and communication.Design/methodology/approach:We first identified the requirements of users via preliminary investigation,and then chose CASI1 P,iLibrary and XKE technology,respectively as the building tools compatible with the major demands of users.These steps helped us complete the layout design of SIC CAS integration platforms,as well as its knowledge organization and integration.Findings:According to the need of users,we applied three types of platform construction technologies to five SIC integration platforms,and formulated standard norms for the further construction process,which could provide useful reference for a sustainable development for the extensive construction in CAS institutes.Research limitations:In order to make the SIC integration platforms more intelligent and have more functions,we need to enlarge the scale of the Platforms and upgrade the building tools for the platform construction.Practical implications:The nature of SIC sub-project integration platforms is to construct a content-sensitive environment which can embed knowledge services and knowledge applications seamlessly into scientific activities,so the Platform is expected to be a useful tool to help researchers better understand the recent development of the research field and form collaborations with their peers.Originality/value:SIC integration platforms are the only pilot construction that used 3different platform technologies in the first batch of knowledge-based subject group integration platforms of the Chinese Academy of Sciences.The construction is user-centered throughout the whole process,namely,from the technology

  10. Resonant-cantilever bio/chemical sensors with an integrated heater for both resonance exciting optimization and sensing repeatability enhancement

    International Nuclear Information System (INIS)

    With an integrated resonance exciting heater and a self-sensing piezoresistor, resonant micro-cantilever bio/chemical sensors are optimally designed and fabricated by micromachining techniques. This study is emphasized on the optimization of the integrated heating resistor. Previous research has put the heater at either the cantilever clamp end, the midpoint or the free end. Aiming at sufficiently high and stable resonant amplitude, our research indicates that the optimized location of the thermal-electric exciting resistor is the clamp end instead of other positions. By both theoretical analysis and resonance experiments where three heating resistors are placed at the three locations of the fabricated cantilever, it is clarified that the clamp end heating provides the most efficient resonance excitation in terms of resonant amplitude, Q-factor and resonance stability. Besides, the optimized combination of dc bias and ac voltage is determined by both analysis and experimental verification. With the optimized heating excitation, the resonant cantilever is used for biotin–avidin-specific detection, resulting in a ±0.1 Hz ultra-low noise floor of the frequency signal and a 130 fg mass resolution. In addition to resonance excitation, the heater is used to heat up the cantilever for speed-up desorption after detection that helps rapid and repeated sensing to chemical vapor. The clamp end is determined (by simulation) as the optimal heating location for uniform temperature distribution on the cantilever. Using the resonant cantilever, a rapid and repeated sensing experiment on dimethyl methylphosphonate (DMMP) vapor shows that a short-period heating at the detection interval significantly quickens the signal recovery and enhances the sensing repeatability

  11. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction

    Science.gov (United States)

    Goto, Yusuke; Yanagi, Itaru; Matsui, Kazuma; Yokoi, Takahide; Takeda, Ken-Ichi

    2016-08-01

    The practical use of solid-state nanopores for DNA sequencing requires easy fabrication of the nanopores, reduction of the DNA movement speed and reduction of the ionic current noise. Here, we report an integrated nanopore platform with a nanobead structure that decelerates DNA movement and an insulating polyimide layer that reduces noise. To enable rapid nanopore fabrication, we introduced a controlled dielectric breakdown (CDB) process into our system. DNA translocation experiments revealed that single nanopores were created by the CDB process without sacrificing performance in reducing DNA movement speed by up to 10 μs/base or reducing noise up to 600 pArms at 1 MHz. Our platform provides the essential components for proceeding to the next step in the process of DNA sequencing.

  12. Polarization rotator-splitters and controllers in a Si3N4-on-SOI integrated photonics platform.

    Science.gov (United States)

    Sacher, Wesley D; Huang, Ying; Ding, Liang; Barwicz, Tymon; Mikkelsen, Jared C; Taylor, Benjamin J F; Lo, Guo-Qiang; Poon, Joyce K S

    2014-05-01

    We demonstrate novel polarization management devices in a custom-designed silicon nitride (Si(3)N(4)) on silicon-on-insulator (SOI) integrated photonics platform. In the platform, Si(3)N(4) waveguides are defined atop silicon waveguides. A broadband polarization rotator-splitter using a TM0-TE1 mode converter in a composite Si(3)N(4)-silicon waveguide is demonstrated. The polarization crosstalk, insertion loss, and polarization dependent loss are less than -19 dB, 1.5 dB, and 1.0 dB, respectively, over a bandwidth of 80 nm. A polarization controller composed of polarization rotator-splitters, multimode interference couplers, and thin film heaters is also demonstrated. PMID:24921814

  13. The integrated platform of controlling and digital video processing for underwater range-gated laser imaging system

    Science.gov (United States)

    Shi, Yan; Qiu, Su; Jin, Wei-qi; Yu, Bing; Li, Li; Tian, Dong-kang

    2015-04-01

    Laser range-gated imaging is one of the effective techniques of underwater optical imaging. It could make the viewing distance up to 4 to 7 times with the video image processing technology. Accordingly, the control and image processing technologies come to be the key technologies for the underwater laser range-gated imaging system. In this article, the integrated platform of controlling and digital video processing for the underwater range-gated laser imaging system based on FPGA has been introduced. It accomplishes both the communication for remote control system as the role of lower computer and the task of high-speed images grabbing and video enhance processing as the role of high-speed image processing platform. The host computer can send commands composed to the FPGA, vectoring the underwater range-gated laser imaging system to executive operation.

  14. Catalyst-Free Vapor-Phase Method for Direct Integration of Gas Sensing Nanostructures with Polymeric Transducing Platforms

    Directory of Open Access Journals (Sweden)

    Stella Vallejos

    2014-01-01

    Full Text Available Tungsten oxide nanoneedles (NNs are grown and integrated directly with polymeric transducing platforms for gas sensors via aerosol-assisted chemical vapor deposition (AACVD method. Material analysis shows the feasibility to grow highly crystalline nanomaterials in the form of NNs with aspect ratios between 80 and 200 and with high concentration of oxygen vacancies at the surface, whereas gas testing demonstrates moderate sensing responses to hydrogen at concentrations between 10 ppm and 50 ppm, which are comparable with results for tungsten oxide NNs grown on silicon transducing platforms. This method is demonstrated to be an attractive route to fabricate next generation of gas sensors devices, provided with flexibility and functionality, with great potential in a cost effective production for large-scale applications.

  15. Integration of a CAD/CAE/CAM operation using various software and platforms

    Energy Technology Data Exchange (ETDEWEB)

    Millaud, J.E.; Goulding, F.S.; Obegi, G.; Whichard, A.

    1988-01-01

    This paper describes how the Lawrence Berkeley Laboratory Electronic Engineering Department responded to a variety of CAD/CAE needs in the changing environment of platforms, operating systems, CAD/CAE software and in the absence of usable exchange standards. 1 ref., 6 figs.

  16. Strategic Industrial Alliances in Paper Industry: XML- vs Ontology-Based Integration Platforms

    Science.gov (United States)

    Naumenko, Anton; Nikitin, Sergiy; Terziyan, Vagan; Zharko, Andriy

    2005-01-01

    Purpose: To identify cases related to design of ICT platforms for industrial alliances, where the use of Ontology-driven architectures based on Semantic web standards is more advantageous than application of conventional modeling together with XML standards. Design/methodology/approach: A comparative analysis of the two latest and the most obvious…

  17. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms.

    Science.gov (United States)

    Stathakarou, Natalia; Zary, Nabil; Kononowicz, Andrzej A

    2014-01-01

    Background. Massive Open Online Courses (MOOCs) are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach. Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a "proof-of-concept" prototype. The resulting pilot implementation was subject of verification by two test cases. Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified. Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale. PMID:25405078

  18. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms

    Directory of Open Access Journals (Sweden)

    Natalia Stathakarou

    2014-11-01

    Full Text Available Background. Massive Open Online Courses (MOOCs are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose of enabling further research into the potential pedagogical benefits of this approach. Methods. We selected OpenEdx and Open Labyrinth as representative constituents of a MOOC platform and Virtual Patient system integration. Based upon our prior experience we selected the most fundamental technical requirement to address. Grounded in the available literature we identified an e-learning standard to guide the integration. We attempted to demonstrate the feasibility of the integration by designing a “proof-of-concept” prototype. The resulting pilot implementation was subject of verification by two test cases. Results. A Single Sign-On mechanism connecting Open Labyrinth with OpenEdx and based on the IMS LTI standard was successfully implemented and verified. Conclusion. We investigated the technical perspective of integrating Virtual Patients with MOOCs. By addressing this crucial technical requirement we set a base for future research on the educational benefits of using virtual patients in MOOCs. This provides new opportunities for integrating specialized software in healthcare education at massive scale.

  19. A Health-IoT Platform Based on the Integration of Intelligent Packaging, Unobtrusive Bio-Sensor and Intelligent Medicine Box

    OpenAIRE

    Yang, Geng; Li, Xie; Mäntysalo, Matti; Zhou, Xiaolin; Pang, Zhibo; Xu, Li Da; Kao-Walter, Sharon; Chen, Qiang; Zheng, Lirong

    2014-01-01

    In-home healthcare services based on the Internet-of-Things (IoT) have great business potential; however, a comprehensive platform is still missing. In this paper, an intelligent home-based platform, the iHome Health-IoT, is proposed and implemented. In particular, the platform involves 1) an open-platform-based intelligent medicine box (iMedBox) with enhanced connectivity and interchangeability for the integration of devices and services, 2) intelligent pharmaceutical packaging (iMedPack) wi...

  20. Status of miniature integrated UV resonance fluorescence and Raman sensors for detection and identification of biochemical warfare agents

    Science.gov (United States)

    Hug, William F.; Bhartia, Rohit; Taspin, Alexandre; Lane, Arthur; Conrad, Pamela; Sijapati, Kripa; Reid, Ray D.

    2005-11-01

    Laser induced native fluorescence (LINF) is the most sensitive method of detection of biological material including microorganisms, virus', and cellular residues. LINF is also a sensitive method of detection for many non-biological materials as well. The specificity with which these materials can be classified depends on the excitation wavelength and the number and location of observation wavelengths. Higher levels of specificity can be obtained using Raman spectroscopy but a much lower levels of sensitivity. Raman spectroscopy has traditionally been employed in the IR to avoid fluorescence. Fluorescence rarely occurs at wavelength below about 270nm. Therefore, when excitation occurs at a wavelength below 250nm, no fluorescence background occurs within the Raman fingerprint region for biological materials. When excitation occurs within electronic resonance bands of the biological target materials, Raman signal enhancement over one million typically occurs. Raman sensitivity within several hundred times fluorescence are possible in the deep UV where most biological materials have strong absorption. Since the Raman and fluorescence emissions occur at different wavelength, both spectra can be observed simultaneously, thereby providing a sensor with unique sensitivity and specificity capability. We will present data on our integrated, deep ultraviolet, LINF/Raman instruments that are being developed for several applications including life detection on Mars as well as biochemical warfare agents on Earth. We will demonstrate the ability to discriminate organic materials based on LINF alone. Together with UV resonance Raman, higher levels of specificity will be demonstrated. In addition, these instruments are being developed as on-line chemical sensors for industrial and municipal waste streams and product quality applications.

  1. Phytochemical composition of Potentilla anserina L. analyzed by an integrative GC-MS and LC-MS metabolomics platform.

    Science.gov (United States)

    Mari, Angela; Lyon, David; Fragner, Lena; Montoro, Paola; Piacente, Sonia; Wienkoop, Stefanie; Egelhofer, Volker; Weckwerth, Wolfram

    2013-06-01

    Potentilla anserina L. (Rosaceae) is known for its beneficial effects of prevention of pre-menstrual syndrome (PMS). For this reason P. anserina is processed into many food supplements and pharmaceutical preparations. Here we analyzed hydroalcoholic reference extracts and compared them with various extracts of different pharmacies using an integrative metabolomics platform comprising GC-MS and LC-MS analysis and software toolboxes for data alignment (MetMAX Beta 1.0) and multivariate statistical analysis (COVAIN 1.0). Multivariate statistics of the integrated GC-MS and LC-MS data showed strong differences between the different plant extract formulations. Different groups of compounds such as chlorogenic acid, kaempferol 3-O-rutinoside, acacetin 7-O-rutinoside, and genistein were reported for the first time in this species. The typical fragmentation pathway of the isoflavone genistein confirmed the identification of this active compound that was present with different abundances in all the extracts analyzed. As a result we have revealed that different extraction procedures from different vendors produce different chemical compositions, e.g. different genistein concentrations. Consequently, the treatment may have different effects. The integrative metabolomics platform provides the highest resolution of the phytochemical composition and a mean to define subtle differences in plant extract formulations. PMID:23678344

  2. Optical MEMS platform for low-cost on-chip integration of planar light circuits and optical switching

    Science.gov (United States)

    German, Kristine A.; Kubby, Joel; Chen, Jingkuang; Diehl, James; Feinberg, Kathleen; Gulvin, Peter; Herko, Larry; Jia, Nancy; Lin, Pinyen; Liu, Xueyuan; Ma, Jun; Meyers, John; Nystrom, Peter; Wang, Yao Rong

    2004-07-01

    Xerox Corporation has developed a technology platform for on-chip integration of latching MEMS optical waveguide switches and Planar Light Circuit (PLC) components using a Silicon On Insulator (SOI) based process. To illustrate the current state of this new technology platform, working prototypes of a Reconfigurable Optical Add/Drop Multiplexer (ROADM) and a l-router will be presented along with details of the integrated latching MEMS optical switches. On-chip integration of optical switches and PLCs can greatly reduce the size, manufacturing cost and operating cost of multi-component optical equipment. It is anticipated that low-cost, low-overhead optical network products will accelerate the migration of functions and services from high-cost long-haul markets to price sensitive markets, including networks for metropolitan areas and fiber to the home. Compared to the more common silica-on-silicon PLC technology, the high index of refraction of silicon waveguides created in the SOI device layer enables miniaturization of optical components, thereby increasing yield and decreasing cost projections. The latching SOI MEMS switches feature moving waveguides, and are advantaged across multiple attributes relative to alternative switching technologies, such as thermal optical switches and polymer switches. The SOI process employed was jointly developed under the auspice of the NIST APT program in partnership with Coventor, Corning IntelliSense Corp., and MicroScan Systems to enable fabrication of a broad range of free space and guided wave MicroOptoElectroMechanical Systems (MOEMS).

  3. Integration of the program TNXYZ in the platform SALOME; Integracion del programa TNXYZ en la plataforma SALOME

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.; Silva A, L.; Del Valle G, E. [IPN, Escuela Superior de Fisica y Matematicas, Av. Instituto Politecnico Nacional s/n, U.P. Adolfo Lopez Mateos, Edificio 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico); Gomez T, A. M.; Vargas E, S., E-mail: javier.paquito@hotmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2013-10-15

    This work presents the procedure realized to integrate the code TNXYZ like a processing tool to the graphic simulation platform SALOME. The code TNXYZ solves the neutron transport equation in stationary state, for several energy groups, quantizing the angular variable by the discrete ordinates method and the space variable by nodal methods. The platform SALOME is a graphic surrounding designed for the construction, edition and simulation of mechanical models focused to the industry and contrary to other software, it allows to integrate external source codes to the surrounding, to form a complete scheme of execution, supervision, pre and post information processing. The code TNXYZ was programmed in the 90s in a Fortran compiler, but to be used at the present time the code should be actualized to the current compiler characteristics; also, in the original scheme was carried out a modularization process, that is to say, the main program was divided in sections where the code carries out important operations, with the intention of flexibility the data extraction process along its processing sequence and that can be useful in a later development of coupling. Finally, to verify the integration a fuel assembly BWR was modeled, as well as a control cell. The cross sections were obtained with the Monte Carlo Serpent code. Some results obtained with Serpent were used to verify and to begin with the validation of the code, being obtained an acceptable comparison in the infinite multiplication factor. The validation process should extend and one has planned to present in a future work. This work is part of the development of the research group formed between the Escuela Superior de Fisica y Matematicas del Instituto Politecnico Nacional (IPN) and the Instituto Nacional de Investigaciones Nucleares (ININ) in which a simulation Mexican platform of nuclear reactors is developed. (Author)

  4. Integration of Personalized Healthcare Pathways in an ICT Platform for Diabetes Managements: A Small-Scale Exploratory Study.

    Science.gov (United States)

    Fico, Giuseppe; Fioravanti, Alessio; Arredondo, Maria Teresa; Gorman, Joe; Diazzi, Chiara; Arcuri, Giovanni; Conti, Claudio; Pirini, Giampiero

    2016-01-01

    The availability of new tools able to support patient monitoring and personalized care may substantially improve the quality of chronic disease management. A personalized healthcare pathway (PHP) has been developed for diabetes disease management and integrated into an information and communication technology system to accomplish a shift from organization-centered care to patient-centered care. A small-scale exploratory study was conducted to test the platform. Preliminary results are presented that shed light on how the PHP influences system usage and performance outcomes. PMID:25389246

  5. Neutron CSI: Integrated platform for non-destructive composition and stress imaging with neutrons

    International Nuclear Information System (INIS)

    We propose to build an interdisciplinary platform for non-destructive analysis and imaging with neutrons. The project regroups an instrument already available at ILL (Laue-Langevin Institute), SALSA, with a new one for Neutron Tomography coupled to Prompt-Gamma Neutron Activation (PGNA) as well as partial usage of another proposed instrument, FIPPS. The focus of the proposition is the versatility of high spatial resolution and energy-selective neutron tomography to provide a rapid and precise 3D morphological map of an object as well as indirect information on its 3D elemental and structural composition through the scan of Bragg-edges in transmission. Coupled to PGNA imaging and the strain analysis power of SALSA, the aim of the platform is to answer key questions occurring in geological, metallurgical, engineering and medical fields, material research and cultural heritage. (authors)

  6. O-miner: an integrative platform for automated analysis and mining of -omics data

    OpenAIRE

    Cutts, Rosalind J.; Dayem Ullah, Abu Z; Sangaralingam, Ajanthah; Gadaleta, Emanuela; Lemoine, Nicholas R.; Chelala, Claude

    2012-01-01

    High-throughput profiling has generated massive amounts of data across basic, clinical and translational research fields. However, open source comprehensive web tools for analysing data obtained from different platforms and technologies are still lacking. To fill this gap and the unmet computational needs of ongoing research projects, we developed O-miner, a rapid, comprehensive, efficient web tool that covers all the steps required for the analysis of both transcriptomic and genomic data sta...

  7. THE ROLE OF AN INTEGRATED E-LEARNING PLATFORM IN INCREASING THE PROCESSMANAGEMENT EFFICIENCY

    OpenAIRE

    Ph. D Student Mihai Logofatu Alexandru Constantin

    2010-01-01

    This paper aims to present the steps taken and solutions implemented at the Cisco Networking Academy of the University of Bucharest in order to increase the process-management efficiency and the student satisfaction degree, mainly via the implementation of an own e-learning learning platform.The results are a significant improvement of work relationships, due to the fact that everyone's responsibilities are clearly defined together with the expectations for each employee. Furthermore, product...

  8. The Naval Postgraduate School's Small Robotics Technology initiative initial platform integration and testing

    OpenAIRE

    Chicoine, Andrew G.

    2001-01-01

    The Naval Postgraduate Schoolαs Small Robotic Technology (SMART) Initiative is an ongoing research effort within the Combat Systems Science and Technology Curriculum that engages in forward-looking applications of small robotic technology for military employment. The goal of the program is to develop a multipurpose robotic platform that is capable of hosting varied sensor packages for military research. This thesis successfully modified a Foster Miller Lemming tracked vehicle: Payload volume...

  9. Analysis of cloud platforms for the purpose of integration with mobile applications

    OpenAIRE

    Mohorčič, David

    2015-01-01

    The main purpose of this diploma dissertation is to compare connections of mobile application with different cloud service providers. At the beginning there are represented six providers of cloud platforms. For each of them we could read what is included within free licence and which sources could be used in payable licence. To make a comparison easier there are also two tables. What is common to all providers is that their service could be connected to the application that is made for Androi...

  10. Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform.

    Directory of Open Access Journals (Sweden)

    Yanli Liu

    Full Text Available Heterogeneity in responses of cells to a stimulus, such as a pathogen or allergen, can potentially play an important role in deciding the fate of the responding cell population and the overall systemic response. Measuring heterogeneous responses requires tools capable of interrogating individual cells. Cell signaling studies commonly do not have single-cell resolution because of the limitations of techniques used such as Westerns, ELISAs, mass spectrometry, and DNA microarrays. Microfluidics devices are increasingly being used to overcome these limitations. Here, we report on a microfluidic platform for cell signaling analysis that combines two orthogonal single-cell measurement technologies: on-chip flow cytometry and optical imaging. The device seamlessly integrates cell culture, stimulation, and preparation with downstream measurements permitting hands-free, automated analysis to minimize experimental variability. The platform was used to interrogate IgE receptor (FcεRI signaling, which is responsible for triggering allergic reactions, in RBL-2H3 cells. Following on-chip crosslinking of IgE-FcεRI complexes by multivalent antigen, we monitored signaling events including protein phosphorylation, calcium mobilization and the release of inflammatory mediators. The results demonstrate the ability of our platform to produce quantitative measurements on a cell-by-cell basis from just a few hundred cells. Model-based analysis of the Syk phosphorylation data suggests that heterogeneity in Syk phosphorylation can be attributed to protein copy number variations, with the level of Syk phosphorylation being particularly sensitive to the copy number of Lyn.

  11. A versatile polypeptide platform for integrated recognition and reporting: affinity arrays for protein-ligand interaction analysis.

    Science.gov (United States)

    Enander, Karin; Dolphin, Gunnar T; Liedberg, Bo; Lundström, Ingemar; Baltzer, Lars

    2004-05-17

    A molecular platform for protein detection and quantification is reported in which recognition has been integrated with direct monitoring of target-protein binding. The platform is based on a versatile 42-residue helix-loop-helix polypeptide that dimerizes to form four-helix bundles and allows site-selective modification with recognition and reporter elements on the side chains of individually addressable lysine residues. The well-characterized interaction between the model target-protein carbonic anhydrase and its inhibitor benzenesulfonamide was used for a proof-of-concept demonstration. An affinity array was designed where benzenesulfonamide derivatives with aliphatic or oligoglycine spacers and a fluorescent dansyl reporter group were introduced into the scaffold. The affinities of the array members for human carbonic anhydrase II (HCAII) were determined by titration with the target protein and were found to be highly affected by the properties of the spacers (dissociation constant Kd=0.02-3 microM). The affinity of HCAII for acetazolamide (Kd=4 nM) was determined in a competition experiment with one of the benzenesulfonamide array members to address the possibility of screening substance libraries for new target-protein binders. Also, successful affinity discrimination between different carbonic anhydrase isozymes highlighted the possibility of performing future isoform-expression profiling. Our platform is predicted to become a flexible tool for a variety of biosensor and protein-microarray applications within biochemistry, diagnostics and pharmaceutical chemistry. PMID:15146511

  12. Quantum dot lasers and integrated optoelectronics on silicon platform Invited Paper

    Institute of Scientific and Technical Information of China (English)

    Jun Yang; Pallab Bhattacharya; Zetian Mi; Guoxuan Qin; Zhenqiang Ma

    2008-01-01

    @@ Chip-scale integration of optoelectronic devices such as lasers, waveguides, and modulators on silicon is prevailing as a promising approach to realize future ultrahigh speed optical interconnects. We review recent progress of the direct epitaxy and fabrication of quantum dot (QD) lasers and integrated guided-wave devices on silicon. This approach involves the development of molecular beam epitaxial growth of selforganized QD lasers directly on silicon substrates and their monolithic integration with amorphous silicon waveguides and quantum well electroabsorption modulators. Additionally, we report a preliminary study of long-wavelength (> 1.3 μm) QD lasers grown on silicon and integrated crystalline silicon waveguides using membrane transfer technology.

  13. Integrating clinical and biological information in a shanghai biobank: an introduction to the sample repository and information sharing platform project.

    Science.gov (United States)

    Cui, Wenbin; Zheng, Peiyong; Yang, Jiahong; Zhao, Rong; Gao, Jiechun; Yu, Guangjun

    2015-02-01

    Biobanks are important resources and central tools for translational medicine, which brings scientific research outcomes to clinical practice. The key purpose of biobanking in translational medicine and other medical research is to provide biological samples that are integrated with clinical information. In 2008, the Shanghai Municipal Government launched the "Shanghai Tissue Bank" in an effort to promote research in translational medicine. Now a sharing service platform has been constructed to integrate clinical practice and biological information that can be used in diverse medical and pharmaceutical research studies. The platform collects two kinds of data: sample data and clinical data. The sample data are obtained from the hospital biobank management system, and mainly include the donors' age, gender, marital status, sample source, sample type, collection time, deposit time, and storage method. The clinical data are collected from the "Hospital-Link" system (a medical information sharing system that connects 23 tertiary hospitals in Shanghai). The main contents include donors' corresponding medication information, test reports, inspection reports, and hospital information. As of the end of September 2014, the project has a collection of 16,020 donors and 148,282 samples, which were obtained from 12 medical institutions, and automatically acquired donors' corresponding clinical data from the "Hospital-Link" system for 6830 occurrences. This project will contribute to scientific research at medical institutions in Shanghai, and will also support the development of the biopharmaceutical industry. In this article, we will describe the significance, the construction phases, the application prospects, and benefits of the sample repository and information sharing service platform. PMID:25686046

  14. OTEC platform configuration and integration. Volume III. Project Plan. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-07-07

    The Spar and Sphere offshore platforms are feasible concepts for the demonstration of a near full size OTEC plant to determine its validity and to gather data for use in the construction, design and operation of commercial OTEC plants. A hull size suitable to support a 100 MWe net output plant was chosen. Either 50, 25 or 12.5 MWe power modules could be used. Selection of 50 MWe modules would permit the testing of equipment recommended for the commercial plant. The use of 25 MWe modules would permit optimal hull volume utilization. The size hull selected for both platforms represents a reasonable increase above the pilot plant, providing design and construction problems similar to those that may be found in a hull size commercial plant. Since the hull size is substantially smaller than the projected commercial plant size, the possiblity of constructing the vessel of steel was presented. However, it is already determined that the full size hull shall be constructed principally of reinforced concrete and thus to fully demonstrate the feasibility of both construction techniques and operation, concrete was chosen for the demonstration plant. The superstructure of the sphere is all steel and for the spar, concrete with a steel deckhouse. The cold water pipe for both platforms is fiberglass. Construction of the hull and installation of all equipment are proposed to take place in three separate phases at three different sites. The overall plan proposes: (1) a shoreside construction site; (2) an offshore site in sufficient water depth to complete the hull erection; and (3) installation of the cold water pipe at the demonstration site.

  15. Nanowaveguides integrated with a mirror as a scalable platform for collective atom-light interaction

    CERN Document Server

    Meng, Y; Dagenais, M; Rolston, S L

    2014-01-01

    We have demonstrated a silicon nitride nanowaveguide that has high fiber-to-waveguide coupling efficiencies for both near-infrared wavelengths of 760nm and 1064nm. A carefully designed inverse taper improves the coupling efficiency from around 1% to more than 60%, and is estimated by a propagation loss measurement with multiple waveguides of different lengths. Such dual-color waveguides may be used to confine laser-cooled atoms in the evanescent field, creating a potentially scalable nanophotonic platform for atomic sensor and quantum information applications.

  16. An integrated software platform for best estimate safety analyses of nuclear power plants

    International Nuclear Information System (INIS)

    Full text of publication follows. Nuclear power plant safety is granted through the demonstration that regulatory acceptance criteria are fulfilled by the provided (calculated) analyses of the NPP performances and sufficient safety margins are respected during normal operation, anticipated transients and postulated accident conditions. Safety margins are very hard to determine in absolute terms, numerical calculations are used to assess their values. Over the last 30 years an extensive effort has been carried out aiming to improve the knowledge of the nuclear power plant behaviour under transient scenarios. The development of Best Estimate (BE) computer codes are the direct consequence of these noteworthy efforts. The availability of more sophisticated and specialized computer codes gives the analyst the possibility to perform very detailed analysis in all the fields involved in the safety of a NPP: thermal-hydraulics, CFD, 3D neutron kinetics etc. The possibility to create a software environment where a multidisciplinary problem can be solved adopting different specialized codes able to exchange data among them is a fruitful approach to the problem aiming to improve the results. The computational tools, adopted in best-estimate approach in licensing, include a) the best estimate computer codes; b) the nodalization together with the procedures for the development and the qualification; c) the uncertainty methodology. The Nuclear Research Group of San Piero a Grado of the University of Pisa has developed a software platform with 15 interacting computer codes. Such platform covers the reactor simulation multidisciplinary problem from generation of neutron cross-sections, through system thermal-hydraulic analyses, up to detailed structural and fuel mechanics studies and it embeds software procedures for automatized data transfer between codes. Together with methodological procedures for nodalization development and qualification the platform leads to a great decrease

  17. Slithering towards autonomy: a self-contained soft robotic snake platform with integrated curvature sensing.

    Science.gov (United States)

    Luo, Ming; Pan, Yixiao; Skorina, Erik H; Tao, Weijia; Chen, Fuchen; Ozel, Selim; Onal, Cagdas D

    2015-10-01

    Soft robotic snakes promise significant advantages in achieving traveling curvature waves with a reduced number of active segments as well as allowing for safe and adaptive interaction with the environment and human users. However, current soft robot platforms suffer from a lack of accurate theoretical dynamic models and proprioceptive measurements, which impede advancements toward full autonomy. To address this gap, this paper details our recent results on the design, fabrication, and experimental evaluation of a new-generation pressure-operated soft robotic snake platform we call the WPI SRS, which employs custom magnetic sensors embedded in a flexible backbone to continuously monitor the curvature of each of its four bidirectional bending segments. In addition, we present a complete and accurate dynamic undulatory locomotion model that accounts for the propagation of frictional moments to describe linear and rotational motions of the SRS. Experimental studies indicate that on-board sensory measurements provide accurate real-time curvature feedback, and numerical simulations offer a level of abstraction for lateral undulation under ideal conditions. PMID:26335857

  18. BNDB – The Biochemical Network Database

    Directory of Open Access Journals (Sweden)

    Kaufmann Michael

    2007-10-01

    Full Text Available Abstract Background Technological advances in high-throughput techniques and efficient data acquisition methods have resulted in a massive amount of life science data. The data is stored in numerous databases that have been established over the last decades and are essential resources for scientists nowadays. However, the diversity of the databases and the underlying data models make it difficult to combine this information for solving complex problems in systems biology. Currently, researchers typically have to browse several, often highly focused, databases to obtain the required information. Hence, there is a pressing need for more efficient systems for integrating, analyzing, and interpreting these data. The standardization and virtual consolidation of the databases is a major challenge resulting in a unified access to a variety of data sources. Description We present the Biochemical Network Database (BNDB, a powerful relational database platform, allowing a complete semantic integration of an extensive collection of external databases. BNDB is built upon a comprehensive and extensible object model called BioCore, which is powerful enough to model most known biochemical processes and at the same time easily extensible to be adapted to new biological concepts. Besides a web interface for the search and curation of the data, a Java-based viewer (BiNA provides a powerful platform-independent visualization and navigation of the data. BiNA uses sophisticated graph layout algorithms for an interactive visualization and navigation of BNDB. Conclusion BNDB allows a simple, unified access to a variety of external data sources. Its tight integration with the biochemical network library BN++ offers the possibility for import, integration, analysis, and visualization of the data. BNDB is freely accessible at http://www.bndb.org.

  19. Sovereign bond market integration: the euro, trading platforms and financial crises

    OpenAIRE

    Schulz, Alexander; Wolff , Guntram B.

    2009-01-01

    We disentangle different driving factors of sovereign bond market integration by studying yield co-movements of EMU countries, the UK, the US and 16 German states (Länder) since 1992. At a low frequency bond market integration has increased gradually in the course of the last 15 years in EMU countries, as well as the UK, the US and the German Länder. The current financial turmoil has abated low frequency euroarea sovereign bond bond market integration, while it has had little effect on the ...

  20. Integrated III-V Photonic Crystal – Si waveguide platform with tailored optomechanical coupling

    OpenAIRE

    Viktor Tsvirkun; Alessandro Surrente; Fabrice Raineri; Grégoire Beaudoin; Rama Raj; Isabelle Sagnes; Isabelle Robert-Philip; Rémy Braive

    2015-01-01

    Optomechanical systems, in which the vibrations of a mechanical resonator are coupled to an electromagnetic radiation, have permitted the investigation of a wealth of novel physical effects. To fully exploit these phenomena in realistic circuits and to achieve different functionalities on a single chip, the integration of optomechanical resonators is mandatory. Here, we propose a novel approach to heterogeneously integrate arrays of two-dimensional photonic crystal defect cavities on top of s...

  1. Integrated management platform of nuclear fuel storage and transportation based on RFID

    International Nuclear Information System (INIS)

    This paper describes integrated system model to improve work efficiency and optimize control measures of nuclear fuel storage and transportation, RFID and information integration technology is introduced, traditional management processes are innovated in data acquisition and monitoring fields as well, system solutions and design model are given by emphasizing on the following key technologies: cascade protection of information system, security protocol of RFID information, algorithm of collision. (authors)

  2. Integration Between SCORM Learning Objects and the CIEMAT Virtual Elearning Platform; Integracion de Objetos de Aprendizaje SCORM con la Plataforma de Ensenanza Virtual del CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Bailador Ferreras, M. A.; Troiani, S.; Gonzalez Giralda, C.; Llorente Herranz, C.; Marco Arboli, M. L.

    2010-08-06

    New information and communications technologies have made a major contribution in the way of understanding the training needs, which have been involved in the change from the traditional teaching to the use of virtual learning platforms. Thus, Ciemat, has installed a virtual platform for education, in particular MOODLE in which have been installed some virtual contents developed with Flash. The next necessary step has been how to integrate the contents with the MOODLE virtual platform, following the aim to know the assessment for learning tracking of the learners. This document provides the technological facts for the integration of the flash virtual contents and the virtual platform in order to achieve the training process is efficiently evaluated. (Author) 5 refs.

  3. Integrated Cu-based TM-pass polarizer using CMOS technology platform

    KAUST Repository

    Ng, Tien Khee

    2010-01-01

    A transverse-magnetic-pass (TM-pass) copper (Cu) polarizer is proposed and analyzed using the previously published two-dimensional Method-of-Lines beam-propagation model. The proposed polarizer exhibits a simulated high-pass filter characteristics, with TM0 and TE0 mode transmissivity of >70% and <5%, respectively, in the wavelength regime of 1.2-1.6 μm. The polarization extinction ratio (PER) given by 10 log10 (PTM0)/(PTE0) is +11.5 dB across the high-pass wavelength regime. To the best of the authors\\' knowledge, we report here the smallest footprint CMOS-platform compatible TM-polarizer.

  4. A Framework to Integrate Public, Dynamic Metrics Into an OER Platform

    Directory of Open Access Journals (Sweden)

    Jaclyn Zetta Cohen

    2014-04-01

    Full Text Available The usage metrics for open educational resources (OER are often either hidden behind an authentication system or shared intermittently in static, aggregated format at the repository level. This paper discusses the first year of University of Michigan’s project to share its OER usage data dynamically, publicly, to synthesize it across different levels within the repository hierarchies, and to aggregate in a method inclusive of content hosted on third-party platforms. The authors analyze their user research with a target audience of faculty authors, multimedia specialists, librarians, and communications specialists. Next, they explore a stratified technical design that allows the dynamic sharing of metrics down to the level of individual resources. The authors conclude that this framework enables sustainable feedback to OER creators, helps to build positive relationships with creators of OER, and allows the institution to move toward sharing OER on a larger scale.

  5. Supplementary immunization activities (SIAs in South Africa: comprehensive economic evaluation of an integrated child health delivery platform

    Directory of Open Access Journals (Sweden)

    Stéphane Verguet

    2013-03-01

    Full Text Available Background: Supplementary immunization activity (SIA campaigns provide children with an additional dose of measles vaccine and deliver other interventions, including vitamin A supplements, deworming medications, and oral polio vaccines. Objective: To assess the cost-effectiveness of the full SIA delivery platform in South Africa (SA. Design: We used an epidemiologic cost model to estimate the cost-effectiveness of the 2010 SIA campaign. We used province-level campaign data sourced from the District Health Information System, SA, and from planning records of provincial coordinators of the Expanded Programme on Immunization. The data included the number of children immunized with measles and polio vaccines, the number of children given vitamin A supplements and Albendazole tablets, and costs. Results: The campaign cost $37 million and averted a total of 1,150 deaths (95% uncertainty range: 990–1,360. This ranged from 380 deaths averted in KwaZulu-Natal to 20 deaths averted in the Northern Cape. Vitamin A supplementation alone averted 820 deaths (95% UR: 670–1,040; measles vaccination alone averted 330 deaths (95% UR: 280–370. Incremental cost-effectiveness was $27,100 (95% UR: $18,500–34,400 per death averted nationally, ranging from $11,300 per death averted in the Free State to $91,300 per death averted in the Eastern Cape. Conclusions: Cost-effectiveness of the SIA child health delivery platform varies substantially across SA provinces, and it is substantially more cost-effective when vitamin A supplementation is included in the interventions administered. Cost-effectiveness assessments should consider health system delivery platforms that integrate multiple interventions, and they should be conducted at the sub-national level.

  6. Virtual Integration Platforms (VIP) –A Concept for Integrated and Interdisciplinary Air Transportation Research and Assessment

    OpenAIRE

    Gollnick, Volker; Stumpf, Eike; Lehner, Stephan; Szodruch, Joachim

    2011-01-01

    The paper descibes a new methodology for a holistic development of air transportation concepts. The Virtual Integration Plattform (VIP) concept is based on an IT tool chain as well as human collaborative methods to deal with complex systems. As a result the definitions of future air transportation concepts for short range "Quiet and Clean", long range "Comfortable and Clean" and individual transport "Fast and Flexible" are presented

  7. Hydro-Quebec adoption and deployment of the integrated Zetec technology platform

    International Nuclear Information System (INIS)

    Steam Generator inspection systems can be integrated using individual technologies from multiple sources or from a single developer. Faced with a significant reduction of the inspection window in 2008, Hydro Quebec required a doubling of its inspection equipment fleet. This paper describes the evaluation of new technologies that led to the decision by Hydro Quebec to set aside their traditional multiple source inspection system in favour of a fully integrated single source inspection system. The paper also describes the qualification and first deployment results as well as performance improvement metrics. (author)

  8. An Integrated Platform for Dynamic Software Updating and its Application in Self-* systems

    DEFF Research Database (Denmark)

    Gregersen, Allan Raundahl; Jørgensen, Bo Nørregaard; Hadaytullah;

    2012-01-01

    Practical dynamic updating of modern Java applications requires tool support to become an integral part of the software development and maintenance lifecycle. In this paper we present Javeleon, an easy-to-use tool for dynamic updates of Java applications. To support integration with specific...... including dynamic changes to the type hierarchy of classes without modifying a JVM and without utilizing new language constructs. In addition to the obvious benefits of using Javeleon during development, we argue that Javeleon is a strong candidate for being useful in other research fields. In order to...... substantiate this argument, we present an overview of an ongoing research that applies Javeleon in the development of Self-* systems....

  9. Integrating Global Learning into a Psychology Course Using an Online Platform

    Science.gov (United States)

    Forden, Carie L.; Carrillo, Amy M.

    2014-01-01

    There is a demand for the integration of global learning/diversity across the curriculum. A series of cross-cultural assignments was created to facilitate global learning in two social psychology classes, one in Egypt, and one in the USA. In these assignments, students collected data and applied course concepts to real-life problems, then…

  10. Perfusion-based three dimensional (3D) tissue engineering platform with integrated bioimpedance sensing

    OpenAIRE

    Muhammad, Haseena Bashir; Canali, Chiara; Heiskanen, Arto; Hemmingsen, Mette; Wolff, Anders; Dufva, Martin; Emnéus, Jenny

    2014-01-01

    We present an 8-channel bioreactor array with integrated bioimpedance sensors, which enables perfusion culture of cells seeded onto porous 3D scaffolds. Results show the capability of the system for monitoring cell proliferation within the scaffolds through a culture period of 19 days.

  11. Perfusion-based three dimensional (3D) tissue engineering platform with integrated bioimpedance sensing

    DEFF Research Database (Denmark)

    Muhammad, Haseena Bashir; Canali, Chiara; Heiskanen, Arto;

    2014-01-01

    We present an 8-channel bioreactor array with integrated bioimpedance sensors, which enables perfusion culture of cells seeded onto porous 3D scaffolds. Results show the capability of the system for monitoring cell proliferation within the scaffolds through a culture period of 19 days....

  12. Oleaginous crops as integrated production platforms for food, feed, fuel and renewable industrial feedstock

    Directory of Open Access Journals (Sweden)

    Beaudoin Frédéric

    2014-11-01

    Full Text Available The world faces considerable challenges including how to produce more biomass for food, feed, fuel and industrial feedstock without significantly impacting on our environment or increasing our consumption of limited resources such as water or petroleum-derived carbon. This has been described as sustainable intensification. Oleaginous crops have the potential to provide renewable resources for all these commodities, provided they can be engineered to meet end-use requirements, and that they can be produced on sufficient scale to meet current growing world population and industrial demand. Although traditional breeding methods have been used successfully to modify the fatty acid composition of oils, metabolic engineering provides a more rapid and direct method for manipulating plant lipid composition. Recent advances in our understanding of the biochemical mechanisms of seed oil biogenesis and the cloning of genes involved in fatty acid and oil metabolic pathways, have allowed the generation of oilseed crops that produce ‘designer oils’ tailored for specific applications and the conversion of high biomass crops into novel oleaginous crops. However, improvement of complex quantitative traits in oilseed crops remains more challenging as the underlying genetic determinants are still poorly understood. Technological advances in sequencing and computing have allowed the development of an association genetics method applicable to crops with complex genomes. Associative transcriptomics approaches and high throughput lipidomic profiling can be used to identify the genetic components controlling quantitative variation for lipid related traits in polyploid crops like oilseed rape and provide molecular tools for marker assisted breeding. In this review we are citing examples of traits with potential for bio-refining that can be harvested as co-products in seeds, but also in non-harvested biomass.

  13. PREPARE: innovative integrated tools and platforms for radiological emergency preparedness and post-accident response in Europe.

    Science.gov (United States)

    Raskob, Wolfgang; Schneider, Thierry; Gering, Florian; Charron, Sylvie; Zhelezniak, Mark; Andronopoulos, Spyros; Heriard-Dubreuil, Gilles; Camps, Johan

    2015-04-01

    The PREPARE project that started in February 2013 and will end at the beginning of 2016 aims to close gaps that have been identified in nuclear and radiological preparedness in Europe following the first evaluation of the Fukushima disaster. Among others, the project will address the review of existing operational procedures for dealing with long-lasting releases and cross-border problems in radiation monitoring and food safety and further develop missing functionalities in decision support systems (DSS) ranging from improved source-term estimation and dispersion modelling to the inclusion of hydrological pathways for European water bodies. In addition, a so-called Analytical Platform will be developed exploring the scientific and operational means to improve information collection, information exchange and the evaluation of such types of disasters. The tools developed within the project will be partly integrated into the two DSS ARGOS and RODOS. PMID:25227442

  14. PREPARE: innovative integrated tools and platforms for radiological emergency preparedness and post-accident response in Europe

    International Nuclear Information System (INIS)

    The PREPARE project that started in February 2013 and will end at the beginning of 2016 aims to close gaps that have been identified in nuclear and radiological preparedness in Europe following the first evaluation of the Fukushima disaster. Among others, the project will address the review of existing operational procedures for dealing with long-lasting releases and cross-border problems in radiation monitoring and food safety and further develop missing functionalities in decision support systems (DSS) ranging from improved source-term estimation and dispersion modelling to the inclusion of hydrological pathways for European water bodies. In addition, a so-called Analytical Platform will be developed exploring the scientific and operational means to improve information collection, information exchange and the evaluation of such types of disasters. The tools developed within the project will be partly integrated into the two DSS ARGOS and RODOS. (authors)

  15. Human health impacts for renewable energy scenarios from the EnerGEO Platform of Integrated Assessment (PIA)

    International Nuclear Information System (INIS)

    This article reports impact results from running the EnerGEO Platform of Integrated Assessment (PIA) related to human health for different scenarios in Europe. The scenarios were prepared within the EnerGEO project. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable energy, affect concentrations of air pollutants and as a consequence affect human health. PM2.5 concentrations were estimated with the IIASA Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) model on a time horizon up to the year 2050 for different scenarios. We analyse here the estimation of the Loss of Life Expectancy due to PM2.5 concentrations for the Baseline scenario taken as a reference and the Maximum renewable power scenario. (orig.)

  16. Investigating the Nexus of Climate, Energy, Water, and Land at Decision-Relevant Scales: The Platform for Regional Integrated Modeling and Analysis (PRIMA)

    Energy Technology Data Exchange (ETDEWEB)

    Kraucunas, Ian P.; Clarke, Leon E.; Dirks, James A.; Hathaway, John E.; Hejazi, Mohamad I.; Hibbard, Kathleen A.; Huang, Maoyi; Jin, Chunlian; Kintner-Meyer, Michael C.W.; Kleese van Dam, Kerstin; Leung, Lai-Yung R.; Li, Hongyi; Moss, Richard H.; Peterson, Marty J.; Rice, Jennie S.; Scott, Michael J.; Thomson, Allison M.; Voisin, Nathalie; West, Tristram O.

    2015-04-01

    The Platform for Regional Integrated Modeling and Analysis (PRIMA) is an innovative modeling system developed at Pacific Northwest National Laboratory (PNNL) to simulate interactions among natural and human systems at scales relevant to regional decision making. PRIMA brings together state-of-the-art models of regional climate, hydrology, agriculture, socioeconomics, and energy systems using a flexible coupling approach. The platform can be customized to inform a variety of complex questions and decisions, such as the integrated evaluation of mitigation and adaptation options across a range of sectors. Research into stakeholder decision support needs underpins the platform's application to regional issues, including uncertainty characterization. Ongoing numerical experiments are yielding new insights into the interactions among human and natural systems on regional scales with an initial focus on the energy-land-water nexus in the upper U.S. Midwest. This paper focuses on PRIMA’s functional capabilities and describes some lessons learned to date about integrated regional modeling.

  17. An integrated platform for large-scale data collection and precise perturbation of live Drosophila embryos

    Science.gov (United States)

    Levario, Thomas J.; Zhao, Charles; Rouse, Tel; Shvartsman, Stanislav Y.; Lu, Hang

    2016-02-01

    Understanding the fundamental principles governing embryogenesis is a key goal of developmental biology. Direct observation of embryogenesis via in vivo live imaging is vital to understanding embryogenesis; yet, tedious sample preparation makes it difficult to acquire large-scale imaging data that is often required to overcome experimental and biological noises for quantitative studies. Furthermore, it is often difficult, and sometimes impossible, to incorporate environmental perturbation for understanding developmental responses to external stimuli. To address this issue, we have developed a method for high-throughput imaging of live embryos, delivering precise environmental perturbations, and unbiased data extraction. This platform includes an optimized microfluidic device specifically for live embryos and also for precise perturbations in the microenvironment of the developing embryos. In addition, we developed software for simple, yet accurate, automated segmentation of fluorescent images, and automated data extraction. Using a quantitative assessment we find that embryos develop normally within the microfluidic device. Finally, we show an application of the high-throughput assay for monitoring developmental responses to external stimuli: anoxia-induced developmental arrest in Drosophila embryos. With slight modifications, the method developed in this work can be applied to many other models of development and other stimulus-response behaviors during development.

  18. The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.

    Science.gov (United States)

    Alva, Vikram; Nam, Seung-Zin; Söding, Johannes; Lupas, Andrei N

    2016-07-01

    The MPI Bioinformatics Toolkit (http://toolkit.tuebingen.mpg.de) is an open, interactive web service for comprehensive and collaborative protein bioinformatic analysis. It offers a wide array of interconnected, state-of-the-art bioinformatics tools to experts and non-experts alike, developed both externally (e.g. BLAST+, HMMER3, MUSCLE) and internally (e.g. HHpred, HHblits, PCOILS). While a beta version of the Toolkit was released 10 years ago, the current production-level release has been available since 2008 and has serviced more than 1.6 million external user queries. The usage of the Toolkit has continued to increase linearly over the years, reaching more than 400 000 queries in 2015. In fact, through the breadth of its tools and their tight interconnection, the Toolkit has become an excellent platform for experimental scientists as well as a useful resource for teaching bioinformatic inquiry to students in the life sciences. In this article, we report on the evolution of the Toolkit over the last ten years, focusing on the expansion of the tool repertoire (e.g. CS-BLAST, HHblits) and on infrastructural work needed to remain operative in a changing web environment. PMID:27131380

  19. SIM-DSP: A DSP-Enhanced CAD Platform for Signal Integrity Macromodeling and Simulation

    Directory of Open Access Journals (Sweden)

    Chi-Un Lei

    2014-12-01

    Full Text Available Macromodeling-Simulation process for signal integrity verifications has become necessary for the high speed circuit system design. This paper aims to introduce a “VLSI Signal Integrity Macromodeling and Simulation via Digital Signal Processing Techniques” framework (known as SIM-DSP framework, which applies digital signal processing techniques to facilitate the SI verification process in the pre-layout design phase. Core identification modules and peripheral (pre-/post-processing modules have been developed and assembled to form a verification flow. In particular, a single-step discrete cosine transform truncation (DCTT module has been developed for modeling-simulation process. In DCTT, the response modeling problem is classified as a signal compression problem, wherein the system response can be represented by a truncated set of non-pole based DCT bases, and error can be analyzed through Parseval’s theorem. Practical examples are given to show the applicability of our proposed framework.

  20. PRISE: An Integrated Platform for Research and Teaching of Critical Embedded Systems

    OpenAIRE

    Hugues, Jérôme; Siron, Pierre; Hamez, Alexandre

    2012-01-01

    In this paper, we present PRISE, an integrated workbench for Research and Teaching of critical embedded systems at ISAE, the French Institute for Space and Aeronautics Engineering. PRISE is built around state-of-the-art technologies for the engineering of space and avionics systems used in Space and Avionics domain. It aims at demonstrating key aspects of critical, real-time, embedded systems used in the transport industry, but also validating new scientific contributions for the engineering ...

  1. Information integration platform for patient-centric healthcare services: design, prototype and dependability aspects

    OpenAIRE

    Yohanes Baptista Dafferianto Trinugroho

    2014-01-01

    Technology innovations have pushed today’s healthcare sector to an unprecedented new level. Various portable and wearable medical and fitness devices are being sold in the consumer market to provide the self-empowerment of a healthier lifestyle to society. Many vendors provide additional cloud-based services for devices they manufacture, enabling the users to visualize, store and share the gathered information through the Internet. However, most of these services are integrated with the devic...

  2. Integrated Quantum Key Distribution sender unit for hand-held platforms

    OpenAIRE

    Mélen, Gwenaelle

    2016-01-01

    Mastering the generation, propagation and detection of electro-magnetic waves has enabled a technological breakthrough that has changed our entire society. World-wide communication through the telephone and the internet has become an integral part of our daily-life, which is expected to grow even further with the emergence of the internet of things. While secure communication was of concern mostly for governmental and financial institutions, digital security has now caught the att...

  3. The design and application of integrated management information platform for nuclear power construction enterprise

    International Nuclear Information System (INIS)

    After the rapid development of information management of nuclear power construction enterprise at the end of last century, a large number of application management information systems were completed. But most of them were confined to a single project management, which formed separated information islands, and was lack of effective communication. As nuclear power construction has been actively promoted in China, enterprises make full use of information technology for effective integration of management at all levels to achieve the indepth development in human, financial, and material resources and to steadily promote the organizational reform, so that enterprises can constantly improve their management concepts to adapt to the new competitive environment. (authors)

  4. Experiences from the formal specification of the integration platform and the synthesis of SDT with the software bus

    International Nuclear Information System (INIS)

    The three year programme 1997-1999 for the OECD Halden Reactor Project (HRP) identifies the need to gain experience from applying formal techniques in real-life system developments. This motivated the initiation of the HRP research activity Integration of Formal Specification in the Development of HAMMLAB 2000 (INT-FS). The principal objective was to experiment with formal techniques in system developments at the HRP; in particular, system developments connected to HAMMLAB 2000 - the computerised laboratory for man-machine-interaction experiments currently under construction. It was hoped that this experimentation with formal techniques should result in a better understanding of how such techniques should be utilised in a more industrial setting. To obtain more knowledge with respect to the practical effects and consequences of an increased level of formalization was another objective. This report summarises experiences, results and conclusions from a pre-study addressing INT-FS related issues connected to the development of the HAMMLAB 2000 Integration Platform (IP). The report starts by giving a brief overview of the IP. Then it describes and summarises experiences from the formalization of a top-level requirements specification for the IP. Finally, it discusses various approaches for the integration of applications generated automatically through the CASE-tool SDT and the Software Bus on which the communication within HAMMLAB 2000 will be based. The report concludes that the selected formalisms and tools are well-suited to describe IP-like systems. The report also concludes that the integration of SDT applications with the Software Bus will not be a major obstacle, and finally that a monitoring component for the IP is well-suited for development within INT-FS (author) (ml)

  5. Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.

    Science.gov (United States)

    Chopda, Viki R; Gomes, James; Rathore, Anurag S

    2016-01-01

    Bioreactor control significantly impacts both the amount and quality of the product being manufactured. The complexity of the control strategy that is implemented increases with reactor size, which may vary from thousands to tens of thousands of litres in commercial manufacturing. The Process Analytical Technology (PAT) initiative has highlighted the need for having robust monitoring tools and effective control schemes that are capable of taking real time information about the critical quality attributes (CQA) and the critical process parameters (CPP) and executing immediate response as soon as a deviation occurs. However, the limited flexibility that present commercial software packages offer creates a hurdle. Visual programming environments have gradually emerged as potential alternatives to the available text based languages. This paper showcases development of an integrated programme using a visual programming environment for a Sartorius BIOSTAT® B Plus 5L bioreactor through which various peripheral devices are interfaced. The proposed programme facilitates real-time access to data and allows for execution of control actions to follow the desired trajectory. Major benefits of such integrated software system include: (i) improved real time monitoring and control; (ii) reduced variability; (iii) improved performance; (iv) reduced operator-training time; (v) enhanced knowledge management; and (vi) easier PAT implementation. PMID:26647285

  6. An integrated assessment of the catchment-scale energy and water balance using a terrestrial systems modeling platform and observations

    Science.gov (United States)

    Sulis, Mauro; Shrestha, Prabhakar; Keune, Jessica; Steinke, Sandra; Diederich, Malte; Schween, Jan; Crewell, Susanne; Simmer, Clemens; Kollet, Stefan

    2016-04-01

    Fully coupled hydrological models close the water and energy cycles while accounting for the dynamic feedbacks between the subsurface, land surface, and atmosphere compartments of terrestrial systems. Diagnoses of their predictive capabilities require spatio-temporal coherent data sets including states and fluxes across the soil-vegetation-atmosphere continuum. This study presents an extensive comparison between numerical simulations carried out using a novel integrated hydrological modeling platform (TerrSysMP) and a suite of cross-compartmental observations obtained from intensive field campaigns and continuous monitoring over the Rur catchment in western Germany during the HOPE experiment (April-May 2013). The observations encompass amongst others rainfall estimates from several X-band radars, atmospheric integrated water vapor estimates from microwave radiometers, radiation and turbulent fluxes at the land surface, and soil moisture retrieval from cosmic-ray probes. A detailed analysis of the radiation components indicates that TerrSysMP systematically overestimates incoming shortwave due to a cloudiness effect, but underestimates incoming longwave due to a lower simulated atmospheric water vapor content. Screening of observed and simulated data for clear sky conditions also reveals mismatches between surface albedo at certain locations within the catchment. Moreover, a preliminary cross-comparison of precipitation and soil moisture suggests that overall the model is able to reproduce catchment dynamics reasonably well while pronounced discrepancies between model and observations were observed in the mountainous region due to the lack of detailed soil parameterization (i.e., soil organic content) and the underestimation of some rainfall events.

  7. Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

    Science.gov (United States)

    Medina, Ignacio; Carbonell, José; Pulido, Luis; Madeira, Sara C.; Goetz, Stefan; Conesa, Ana; Tárraga, Joaquín; Pascual-Montano, Alberto; Nogales-Cadenas, Ruben; Santoyo, Javier; García, Francisco; Marbà, Martina; Montaner, David; Dopazo, Joaquín

    2010-01-01

    Babelomics is a response to the growing necessity of integrating and analyzing different types of genomic data in an environment that allows an easy functional interpretation of the results. Babelomics includes a complete suite of methods for the analysis of gene expression data that include normalization (covering most commercial platforms), pre-processing, differential gene expression (case-controls, multiclass, survival or continuous values), predictors, clustering; large-scale genotyping assays (case controls and TDTs, and allows population stratification analysis and correction). All these genomic data analysis facilities are integrated and connected to multiple options for the functional interpretation of the experiments. Different methods of functional enrichment or gene set enrichment can be used to understand the functional basis of the experiment analyzed. Many sources of biological information, which include functional (GO, KEGG, Biocarta, Reactome, etc.), regulatory (Transfac, Jaspar, ORegAnno, miRNAs, etc.), text-mining or protein–protein interaction modules can be used for this purpose. Finally a tool for the de novo functional annotation of sequences has been included in the system. This provides support for the functional analysis of non-model species. Mirrors of Babelomics or command line execution of their individual components are now possible. Babelomics is available at http://www.babelomics.org. PMID:20478823

  8. Functional integrity of flexible n-channel metal-oxide-semiconductor field-effect transistors on a reversibly bistable platform

    Science.gov (United States)

    Alfaraj, Nasir; Hussain, Aftab M.; Torres Sevilla, Galo A.; Ghoneim, Mohamed T.; Rojas, Jhonathan P.; Aljedaani, Abdulrahman B.; Hussain, Muhammad M.

    2015-10-01

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal-oxide-semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  9. Integrated reconfigurable multiple-input–multiple-output antenna system with an ultra-wideband sensing antenna for cognitive radio platforms

    KAUST Repository

    Hussain, Rifaqat

    2015-06-18

    © The Institution of Engineering and Technology 2015. A compact, novel multi-mode, multi-band frequency reconfigurable multiple-input-multiple-output (MIMO) antenna system, integrated with ultra-wideband (UWB) sensing antenna, is presented. The developed model can be used as a complete antenna platform for cognitive radio applications. The antenna system is developed on a single substrate area of dimensions 65 × 120 mm2. The proposed sensing antenna is used to cover a wide range of frequency bands from 710 to 3600 MHz. The frequency reconfigurable dual-element MIMO antenna is integrated with P-type, intrinsic, N-type (PIN) diodes for frequency agility. Different modes of selection are used for the MIMO antenna system reconfigurability to support different wireless system standards. The proposed MIMO antenna configuration is used to cover various frequency bands from 755 to 3450 MHz. The complete system comprising the multi-band reconfigurable MIMO antennas and UWB sensing antenna for cognitive radio applications is proposed with a compact form factor.

  10. Functional integrity of flexible n-channel metal–oxide–semiconductor field-effect transistors on a reversibly bistable platform

    International Nuclear Information System (INIS)

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal–oxide–semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties

  11. Functional integrity of flexible n-channel metal–oxide–semiconductor field-effect transistors on a reversibly bistable platform

    KAUST Repository

    Alfaraj, Nasir

    2015-10-26

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal–oxide–semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  12. Synthetic Biology Platform for Sensing and Integrating Endogenous Transcriptional Inputs in Mammalian Cells.

    Science.gov (United States)

    Angelici, Bartolomeo; Mailand, Erik; Haefliger, Benjamin; Benenson, Yaakov

    2016-08-30

    One of the goals of synthetic biology is to develop programmable artificial gene networks that can transduce multiple endogenous molecular cues to precisely control cell behavior. Realizing this vision requires interfacing natural molecular inputs with synthetic components that generate functional molecular outputs. Interfacing synthetic circuits with endogenous mammalian transcription factors has been particularly difficult. Here, we describe a systematic approach that enables integration and transduction of multiple mammalian transcription factor inputs by a synthetic network. The approach is facilitated by a proportional amplifier sensor based on synergistic positive autoregulation. The circuits efficiently transduce endogenous transcription factor levels into RNAi, transcriptional transactivation, and site-specific recombination. They also enable AND logic between pairs of arbitrary transcription factors. The results establish a framework for developing synthetic gene networks that interface with cellular processes through transcriptional regulators. PMID:27545896

  13. Requirements for data integration platforms in biomedical research networks: a reference model

    Directory of Open Access Journals (Sweden)

    Matthias Ganzinger

    2015-02-01

    Full Text Available Biomedical research networks need to integrate research data among their members and with external partners. To support such data sharing activities, an adequate information technology infrastructure is necessary. To facilitate the establishment of such an infrastructure, we developed a reference model for the requirements. The reference model consists of five reference goals and 15 reference requirements. Using the Unified Modeling Language, the goals and requirements are set into relation to each other. In addition, all goals and requirements are described textually in tables. This reference model can be used by research networks as a basis for a resource efficient acquisition of their project specific requirements. Furthermore, a concrete instance of the reference model is described for a research network on liver cancer. The reference model is transferred into a requirements model of the specific network. Based on this concrete requirements model, a service-oriented information technology architecture is derived and also described in this paper.

  14. SYSTEM FOR TORQUE CONVERTER DESIGN AND ANALYSIS BASED ON CAD/CFD INTEGRATED PLATFORM

    Institute of Scientific and Technical Information of China (English)

    WU Guangqiang; YAN Peng

    2008-01-01

    A 3D torque converter design system is developed based on numerical investigation into flow field and CAD technology. The 3D steady-state flow field simulation is undertaken by using time averaged Reynolds equation and k-epsilon turbulence model, with mixing-plane boundary conditions at three section interfaces. The blades are designed according to the flow field characteristics by using a reverse design method in the system. The accurateness of numerical analysis and the validity of design system are verified by the fluid field experiment of desingn example of the torque converter. This kind of design and analysis system for torque converter based on integration of comput ationol fluid dynamics (CFD) and CAD is a powerful tool for torque converter manufacturing, but also a prettg important significance for research and development.

  15. Platform of integrated tools to support environmental studies and management of dredging activities.

    Science.gov (United States)

    Feola, Alessandra; Lisi, Iolanda; Salmeri, Andrea; Venti, Francesco; Pedroncini, Andrea; Gabellini, Massimo; Romano, Elena

    2016-01-15

    Dredging activities can cause environmental impacts due to, among other, the increase of the Suspended Solid Concentration (SSC) and their subsequent dispersion and deposition (DEP) far from the dredging point. The dynamics of the resulting dredging plume can strongly differ in spatial and temporal evolution. This evolution, for both conventional mechanical and hydraulic dredges, depends on the different mechanisms of sediment release in water column and the site-specific environmental conditions. Several numerical models are currently in use to simulate the dredging plume dynamics. Model results can be analysed to study dispersion and advection processes at different depths and distances from the dredging source. Usually, scenarios with frequent and extreme meteomarine conditions are chosen and extreme values of parameters (i.e. maximum intensity or total duration) are evaluated for environmental assessment. This paper presents a flexible, consistent and integrated methodological approach. Statistical parameters and indexes are derived from the analysis of SSC and DEP simulated time-series to numerically estimate their spatial (vertical and horizontal) and seasonal variability, thereby allowing a comparison of the effects of hydraulic and mechanical dredges. Events that exceed defined thresholds are described in term of magnitude, duration and frequency. A new integrated index combining these parameters, SSCnum, is proposed for environmental assessment. Maps representing the proposed parameters allow direct comparison of effects due to different (mechanical and hydraulic) dredges at progressive distances from the dredging zone. Results can contribute towards identification and assessment of the potential environmental effects of a proposed dredging project. A suitable evaluation of alternative technical choices, appropriate mitigation, management and monitoring measure is allowed in this framework. Environmental Risk Assessment and Decision Support Systems (DSS

  16. Development of a data assimilation system for the integrated terrestrial system modelling platform TerrSysMP

    Science.gov (United States)

    Kurtz, Wolfgang; He, Guowei; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Integrated hydrological models are increasingly applied in hydrological studies because they allow a better physical representation of processes and feedbacks across compartments and a more integrated view of the hydrological cycle. An example of such an integrated modeling approach is the recently established integrated modeling platform TerrSysMP consisting of individual component models for variably saturated subsurface flow (ParFlow), land surface processes (CLM3.5) and weather forecast (COSMO). The component models are dynamically linked by the exchange of state variables and fluxes with the coupling software OASIS-MCT in a scale-consistent, modular manner. While integrated models may provide better estimates of state and flux variables, model predictions remain to be impacted by a considerable degree of uncertainty due to uncertain initial conditions and forcings, and the poorly known subsurface and vegetation properties. Data assimilation methods allow to better constrain the model predictions and parameters and the associated uncertainties. In a first step, we constructed a data assimilation framework for the land surface-subsurface part of TerrSysMP (CLM and ParFlow) by linking TerrSysMP with the PDAF (Parallel Data Assimilation Framework) software which is specifically designed for parallel simulation models and provides several global and local filter algorithms (e.g., EnKF, LETKF). The data assimilation framework uses a memory based communication between model and data assimilation routines and avoids frequent re-initializations of the model and is thus highly scalable and applicable to large scale hydrological systems. Currently, data assimilation is restricted to the subsurface part of TerrSysMP (i.e. ParFlow) in which pressure (or soil moisture) data can be assimilated. The feasibility of this approach is demonstrated with a synthetic model setup where groundwater levels and soil moisture data are assimilated with the ensemble Kalman filter into a

  17. T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Sriram S

    2008-07-01

    Full Text Available Abstract Background Type 2 Diabetes Mellitus (T2DM is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors. The advanced stage in type 2 diabetes mellitus leads to several micro and macro vascular complications like nephropathy, neuropathy, retinopathy, heart related problems etc. Studies performed on the genetics, biochemistry and molecular biology of this disease to understand the pathophysiology of type 2 diabetes mellitus has led to the generation of a surfeit of data on candidate genes and related aspects. The research is highly progressive towards defining the exact etiology of this disease. Results T2D-Db (Type 2 diabetes Database is a comprehensive web resource, which provides integrated and curated information on almost all known molecular components involved in the pathogenesis of type 2 diabetes mellitus in the three widely studied mammals namely human, mouse and rat. Information on candidate genes, SNPs (Single Nucleotide Polymorphism in candidate genes or candidate regions, genome wide association studies (GWA, tissue specific gene expression patterns, EST (Expressed Sequence Tag data, expression information from microarray data, pathways, protein-protein interactions and disease associated risk factors or complications have been structured in this on line resource. Conclusion Information available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. Importantly, the resource facilitates graphical presentation of the gene/genome wide map of SNP markers and protein-protein interaction networks, besides providing the heat map diagram of the selected gene(s in an organism across microarray expression experiments from either single or multiple studies. These features aid to the data interpretation in an integrative way. T2D-Db is to our knowledge the first publicly available resource that

  18. An ultrahigh-accuracy Miniature Dew Point Sensor based on an Integrated Photonics Platform

    Science.gov (United States)

    Tao, Jifang; Luo, Yu; Wang, Li; Cai, Hong; Sun, Tao; Song, Junfeng; Liu, Hui; Gu, Yuandong

    2016-01-01

    The dew point is the temperature at which vapour begins to condense out of the gaseous phase. The deterministic relationship between the dew point and humidity is the basis for the industry-standard “chilled-mirror” dew point hygrometers used for highly accurate humidity measurements, which are essential for a broad range of industrial and metrological applications. However, these instruments have several limitations, such as high cost, large size and slow response. In this report, we demonstrate a compact, integrated photonic dew point sensor (DPS) that features high accuracy, a small footprint, and fast response. The fundamental component of this DPS is a partially exposed photonic micro-ring resonator, which serves two functions simultaneously: 1) sensing the condensed water droplets via evanescent fields and 2) functioning as a highly accurate, in situ temperature sensor based on the thermo-optic effect (TOE). This device virtually eliminates most of the temperature-related errors that affect conventional “chilled-mirror” hygrometers. Moreover, this DPS outperforms conventional “chilled-mirror” hygrometers with respect to size, cost and response time, paving the way for on-chip dew point detection and extension to applications for which the conventional technology is unsuitable because of size, cost, and other constraints. PMID:27417734

  19. An ultrahigh-accuracy Miniature Dew Point Sensor based on an Integrated Photonics Platform.

    Science.gov (United States)

    Tao, Jifang; Luo, Yu; Wang, Li; Cai, Hong; Sun, Tao; Song, Junfeng; Liu, Hui; Gu, Yuandong

    2016-01-01

    The dew point is the temperature at which vapour begins to condense out of the gaseous phase. The deterministic relationship between the dew point and humidity is the basis for the industry-standard "chilled-mirror" dew point hygrometers used for highly accurate humidity measurements, which are essential for a broad range of industrial and metrological applications. However, these instruments have several limitations, such as high cost, large size and slow response. In this report, we demonstrate a compact, integrated photonic dew point sensor (DPS) that features high accuracy, a small footprint, and fast response. The fundamental component of this DPS is a partially exposed photonic micro-ring resonator, which serves two functions simultaneously: 1) sensing the condensed water droplets via evanescent fields and 2) functioning as a highly accurate, in situ temperature sensor based on the thermo-optic effect (TOE). This device virtually eliminates most of the temperature-related errors that affect conventional "chilled-mirror" hygrometers. Moreover, this DPS outperforms conventional "chilled-mirror" hygrometers with respect to size, cost and response time, paving the way for on-chip dew point detection and extension to applications for which the conventional technology is unsuitable because of size, cost, and other constraints. PMID:27417734

  20. Human Disease Insight: An integrated knowledge-based platform for disease-gene-drug information.

    Science.gov (United States)

    Tasleem, Munazzah; Ishrat, Romana; Islam, Asimul; Ahmad, Faizan; Hassan, Md Imtaiyaz

    2016-01-01

    The scope of the Human Disease Insight (HDI) database is not limited to researchers or physicians as it also provides basic information to non-professionals and creates disease awareness, thereby reducing the chances of patient suffering due to ignorance. HDI is a knowledge-based resource providing information on human diseases to both scientists and the general public. Here, our mission is to provide a comprehensive human disease database containing most of the available useful information, with extensive cross-referencing. HDI is a knowledge management system that acts as a central hub to access information about human diseases and associated drugs and genes. In addition, HDI contains well-classified bioinformatics tools with helpful descriptions. These integrated bioinformatics tools enable researchers to annotate disease-specific genes and perform protein analysis, search for biomarkers and identify potential vaccine candidates. Eventually, these tools will facilitate the analysis of disease-associated data. The HDI provides two types of search capabilities and includes provisions for downloading, uploading and searching disease/gene/drug-related information. The logistical design of the HDI allows for regular updating. The database is designed to work best with Mozilla Firefox and Google Chrome and is freely accessible at http://humandiseaseinsight.com. PMID:26631432

  1. Microfabrication of a digital microfluidic platform integrated with an on-chip electrochemical cell

    International Nuclear Information System (INIS)

    We report on an IC compatible microfabrication process proposed for a novel monolithic lab-on-a-chip (LOC) with an electrochemical cell embedded in an electrowetting on dielectric (EWOD) digital microfluidic device. The optimized process focused on the surface modification of Teflon, selective exposure for the electrochemical module and recovery of surface properties by one-step annealing at low temperature. The optimum modification time and annealing temperature were 20 s and 210 °C, respectively. The experimental results from atomic force microscope and contact angle (CA) measurement revealed the effects of surface roughness and apparent CA on the wettability for different etch times. The multifunctionality of droplet creation, merger and transportation in the EWOD microfluidic module and sensitive electrochemical detection for the redox probe were realized simultaneously. The proposed microfabrication process has many advantages of remarkable simplicity, prominent repeatability, low cost and compatibility with standard IC processes. It shows great promise for the microsystem of the microfluidic unit and detecting cell, and gives a brilliant conception for the future fabrication of monolithic LOC integrated with functional detection. (paper)

  2. An integrated approach for gas dispersion, gas explosion and structural impact analysis for an offshore production platform on the Dutch continental shelf

    OpenAIRE

    Korndörffer, W.; Schaap, D.; Van der Heijden, A.M.A.; Versloot, N.H.A.

    2004-01-01

    The design of an offshore gas production platform has been subjected to an extensive quantitative risk analysis in particular with regard to its resistance to gas explosions loads. It was demonstrated that integration of the physical and structural effects of a gas explosion in an early stage of the design results in a safe and economical design. Copyright 2004, Offshore Technology Conference.

  3. Leveraging HIV platforms to work toward comprehensive primary care in rural Malawi: the Integrated Chronic Care Clinic.

    Science.gov (United States)

    Wroe, Emily B; Kalanga, Noel; Mailosi, Bright; Mwalwanda, Stanley; Kachimanga, Chiyembekezo; Nyangulu, Kondwani; Dunbar, Elizabeth; Kerr, Lila; Nazimera, Lawrence; Dullie, Luckson

    2015-12-01

    This case study describes an integrated chronic care clinic that utilizes a robust HIV program as a platform for NCD screening and treatment. A unique model, the integrated chronic care clinic provides longitudinal care for patients with an array of chronic diseases including HIV and common NCDs, allowing for a single visit for all of a patient's conditions. Set in Malawi's remote Neno District, this clinic structure aims to (1) increase access to care for NCD patients, (2) maximize efficiency given the severe human resource shortages, and (3) replicate strong HIV outcomes for patients with other chronic conditions. The goal is to increase the number of health facilities in Neno capable of fully delivering Malawi's Essential Health Package, the set of cost-effective interventions endorsed by Malawi MOH to reduce burden of disease and leading causes of death. While implementation is ongoing and processes are evolving, this model of healthcare delivery has already improved the accessibility of NCD care by allowing patients to have all of their chronic conditions treated on the same day at their nearest health facility, notably without additional investment of human and financial resources. Currently, 6781 patients on antiretroviral therapy and 721 patients with NCDs are benefitting, including 379 with hypertension, 187 with asthma, 144 with epilepsy, and 76 with diabetes. Among the NCD patient population, 15.1% are HIV-positive. Success hinged largely on several factors, including clear leadership and staff ownership of their specific duties, and a well-defined and uniform patient flow process. Furthermore, deliberate and regular conversations about challenges allowed for constant iteration and improvement of processes. Moving forward, several tasks remain. We are refining the data management process to further consolidate medical records, along with integrating our tracking processes for clients who miss appointments. Additionally, we are exploring opportunities for

  4. MiMiR – an integrated platform for microarray data sharing, mining and analysis

    Directory of Open Access Journals (Sweden)

    Maratou Klio

    2008-09-01

    Full Text Available Abstract Background Despite considerable efforts within the microarray community for standardising data format, content and description, microarray technologies present major challenges in managing, sharing, analysing and re-using the large amount of data generated locally or internationally. Additionally, it is recognised that inconsistent and low quality experimental annotation in public data repositories significantly compromises the re-use of microarray data for meta-analysis. MiMiR, the Microarray data Mining Resource was designed to tackle some of these limitations and challenges. Here we present new software components and enhancements to the original infrastructure that increase accessibility, utility and opportunities for large scale mining of experimental and clinical data. Results A user friendly Online Annotation Tool allows researchers to submit detailed experimental information via the web at the time of data generation rather than at the time of publication. This ensures the easy access and high accuracy of meta-data collected. Experiments are programmatically built in the MiMiR database from the submitted information and details are systematically curated and further annotated by a team of trained annotators using a new Curation and Annotation Tool. Clinical information can be annotated and coded with a clinical Data Mapping Tool within an appropriate ethical framework. Users can visualise experimental annotation, assess data quality, download and share data via a web-based experiment browser called MiMiR Online. All requests to access data in MiMiR are routed through a sophisticated middleware security layer thereby allowing secure data access and sharing amongst MiMiR registered users prior to publication. Data in MiMiR can be mined and analysed using the integrated EMAAS open source analysis web portal or via export of data and meta-data into Rosetta Resolver data analysis package. Conclusion The new MiMiR suite of software

  5. Integration of the TNXYZ computer program inside the platform Salome; Integracion del programa de computo TNXYZ dentro de la plataforma Salome

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro V, F. J.

    2014-07-01

    The present work shows the procedure carried out to integrate the code TNXYZ as a calculation tool at the graphical simulation platform Salome. The TNXYZ code propose a numerical solution of the neutron transport equation, in several groups of energy, steady-state and three-dimensional geometry. In order to discretized the variables of the transport equation, the code uses the method of discrete ordinates for the angular variable, and a nodal method for the spatial dependence. The Salome platform is a graphical environment designed for building, editing and simulating mechanical models mainly focused on the industry and unlike other software, in order to form a complete scheme of pre and post processing of information, to integrate and control an external source code. Before the integration the in the Salome platform TNXYZ code was upgraded. TNXYZ was programmed in the 90s using Fortran 77 compiler; for this reason the code was adapted to the characteristics of the current Fortran compilers; in addition, with the intention of extracting partial results over the process sequence, the original structure of the program underwent a modularization process, i.e. the main program was divided into sections where the code performs major operations. This procedure is controlled by the information module (YACS) on Salome platform, and it could be useful for a subsequent coupling with thermal-hydraulics codes. Finally, with the help of the Monte Carlo code Serpent several study cases were defined in order to check the process of integration; the verification process consisted in performing a comparison of the results obtained with the code executed as stand-alone and after modernized, integrated and controlled by the Salome platform. (Author)

  6. MALDI-TOF-MS Platform for Integrated Proteomic and Peptidomic Profiling of Milk Samples Allows Rapid Detection of Food Adulterations.

    Science.gov (United States)

    Sassi, Mauro; Arena, Simona; Scaloni, Andrea

    2015-07-15

    Adulteration of ovine, caprine, and buffalo milks with more common bovine material occurs for economic reasons and seasonal availability. Frauds are also associated with the use of powdered milk instead of declared, fresh material. In this context, various analytical methods have been adapted to dairy science applications with the aim to evaluate adulteration of milk samples, although time-consuming, suitable only for speciation or thermal treatment analysis, or useful for a specific fraud type. An integrated MALDI-TOF-MS platform for the combined peptidomic and proteomic profiling of milk samples is here presented, which allows rapid detection of illegal adulterations due to the addition of either nondeclared bovine material to water buffalo, goat, and ovine milks or of powdered bovine milk to the fresh counterpart. Peptide and protein markers of each animal milk were identified after direct analysis of a large number of diluted skimmed and/or enriched diluted skimmed filtrate samples. In parallel, markers of thermal treatment were characterized in different types of commercial milks. Principal components scores of ad hoc prepared species- or thermal treatment-associated adulterated milk samples were subjected to partial least-squares regression, permitting a fast accurate estimate of the fraud extents in test samples at either protein and peptide level. With respect to previous reports on MALDI-TOF-MS protein profiling methodologies for milk speciation, this study extends that approach to the analysis of the thermal treatment and introduces an independent, complementary peptide profiling measurement, which integrates protein data with additional information on peptides, validating final results and ultimately broadening the method applicability. PMID:26098723

  7. ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings.

    Science.gov (United States)

    Pelletier, D; Wiegers, T C; Enayetallah, A; Kibbey, C; Gosink, M; Koza-Taylor, P; Mattingly, C J; Lawton, M

    2016-01-01

    Attempts are frequently made to investigate adverse findings from preclinical toxicology studies in order to better understand underlying toxicity mechanisms. These efforts often begin with limited information, including a description of the adverse finding, knowledge of the structure of the chemical associated with its cause and the intended pharmacological target. ToxEvaluator was developed jointly by Pfizer and the Comparative Toxicogenomics Database (http://ctdbase.org) team at North Carolina State University as an in silico platform to facilitate interpretation of toxicity findings in light of prior knowledge. Through the integration of a diverse set of in silico tools that leverage a number of public and proprietary databases, ToxEvaluator streamlines the process of aggregating and interrogating diverse sources of information. The user enters compound and target identifiers, and selects adverse event descriptors from a safety lexicon and mapped MeSH disease terms. ToxEvaluator provides a summary report with multiple distinct areas organized according to what target or structural aspects have been linked to the adverse finding, including primary pharmacology, structurally similar proprietary compounds, structurally similar public domain compounds, predicted secondary (i.e. off-target) pharmacology and known secondary pharmacology. Similar proprietary compounds and their associated in vivo toxicity findings are reported, along with a link to relevant supporting documents. For similar public domain compounds and interacting targets, ToxEvaluator integrates relationships curated in Comparative Toxicogenomics Database, returning all direct and inferred linkages between them. As an example of its utility, we demonstrate how ToxEvaluator rapidly identified direct (primary pharmacology) and indirect (secondary pharmacology) linkages between cerivastatin and myopathy. PMID:27161010

  8. The road map towards providing a robust Raman spectroscopy-based cancer diagnostic platform and integration into clinic

    Science.gov (United States)

    Lau, Katherine; Isabelle, Martin; Lloyd, Gavin R.; Old, Oliver; Shepherd, Neil; Bell, Ian M.; Dorney, Jennifer; Lewis, Aaran; Gaifulina, Riana; Rodriguez-Justo, Manuel; Kendall, Catherine; Stone, Nicolas; Thomas, Geraint; Reece, David

    2016-03-01

    Despite the demonstrated potential as an accurate cancer diagnostic tool, Raman spectroscopy (RS) is yet to be adopted by the clinic for histopathology reviews. The Stratified Medicine through Advanced Raman Technologies (SMART) consortium has begun to address some of the hurdles in its adoption for cancer diagnosis. These hurdles include awareness and acceptance of the technology, practicality of integration into the histopathology workflow, data reproducibility and availability of transferrable models. We have formed a consortium, in joint efforts, to develop optimised protocols for tissue sample preparation, data collection and analysis. These protocols will be supported by provision of suitable hardware and software tools to allow statistically sound classification models to be built and transferred for use on different systems. In addition, we are building a validated gastrointestinal (GI) cancers model, which can be trialled as part of the histopathology workflow at hospitals, and a classification tool. At the end of the project, we aim to deliver a robust Raman based diagnostic platform to enable clinical researchers to stage cancer, define tumour margin, build cancer diagnostic models and discover novel disease bio markers.

  9. Identification and confirmation of biomarkers using an integrated platform for quantitative analysis of glycoproteins and their glycosylations.

    Science.gov (United States)

    Liu, Yashu; He, Jintang; Li, Chen; Benitez, Ricardo; Fu, Sherry; Marrero, Jorge; Lubman, David M

    2010-02-01

    Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. However, accurate diagnosis can be difficult as most of the patients who develop this tumor have symptoms similar to those caused by longstanding liver disease. Herein we developed an integrated platform to discover the glycoprotein biomarkers in early HCC. At first, lectin arrays were applied to investigate the differences in glycan structures on serum glycoproteins from HCC and cirrhosis patients. The intensity for AAL and LCA was significantly higher in HCC, indicating an elevation of fucosylation level. Then serum from 10 HCC samples and 10 cirrhosis samples were used to screen the altered fucosylated proteins by a combination of Exactag labeling, lectin extraction and LC-MS/MS. Finally, 27 HCC and 27 cirrhosis serum samples were used for lectin-antibody arrays to confirm the change of these fucosylated proteins. C3, CE, HRG, CD14 and HGF were found to be biomarker candidates for distinguishing early HCC from cirrhosis, with a sensitivity of 72% and specificity of 79%. Our work gives insight to the detection of early HCC, and the application of this comprehensive strategy has the potential to facilitate biomarker discovery on a large scale. PMID:19961239

  10. Ensembles of indium phosphide nanowires: physical properties and functional devices integrated on non-single crystal platforms

    International Nuclear Information System (INIS)

    A new route to grow an ensemble of indium phosphide single-crystal semiconductor nanowires is described. Unlike conventional epitaxial growth of single-crystal semiconductor films, the proposed route for growing semiconductor nanowires does not require a single-crystal semiconductor substrate. In the proposed route, instead of using single-crystal semiconductor substrates that are characterized by their long-range atomic ordering, a template layer that possesses short-range atomic ordering prepared on a non-single-crystal substrate is employed. On the template layer, epitaxial information associated with its short-range atomic ordering is available within an area that is comparable to that of a nanowire root. Thus the template layer locally provides epitaxial information required for the growth of semiconductor nanowires. In the particular demonstration described in this paper, hydrogenated silicon was used as a template layer for epitaxial growth of indium phosphide nanowires. The indium phosphide nanowires grown on the hydrogenerated silicon template layer were found to be single crystal and optically active. Simple photoconductors and pin-diodes were fabricated and tested with the view towards various optoelectronic device applications where group III-V compound semiconductors are functionally integrated onto non-single-crystal platforms. (orig.)

  11. Towards a fully functional integrated photonic-electronic platform via a single SiGe growth step.

    Science.gov (United States)

    Littlejohns, Callum G; Dominguez Bucio, Thalia; Nedeljkovic, Milos; Wang, Hong; Mashanovich, Goran Z; Reed, Graham T; Gardes, Frederic Y

    2016-01-01

    Silicon-germanium (Si(1-x)Ge(x)) has become a material of great interest to the photonics and electronics industries due to its numerous interesting properties including higher carrier mobilities than Si, a tuneable lattice constant, and a tuneable bandgap. In previous work, we have demonstrated the ability to form localised areas of single crystal, uniform composition SiGe-on-insulator. Here we present a method of simultaneously growing several areas of SiGe-on-insulator on a single wafer, with the ability to tune the composition of each localised SiGe area, whilst retaining a uniform composition in that area. We use a rapid melt growth technique that comprises of only a single Ge growth step and a single anneal step. This innovative method is key in working towards a fully integrated photonic-electronic platform, enabling the simultaneous growth of multiple compositions of device grade SiGe for electro-absorption optical modulators operating at a range of wavelengths, photodetectors, and bipolar transistors, on the same wafer. This is achieved by modifying the structural design of the SiGe strips, without the need to modify the growth conditions, and by using low cost, low thermal-budget methods. PMID:26783267

  12. Towards a fully functional integrated photonic-electronic platform via a single SiGe growth step

    Science.gov (United States)

    Littlejohns, Callum G.; Dominguez Bucio, Thalia; Nedeljkovic, Milos; Wang, Hong; Mashanovich, Goran Z.; Reed, Graham T.; Gardes, Frederic Y.

    2016-01-01

    Silicon-germanium (Si1-xGex) has become a material of great interest to the photonics and electronics industries due to its numerous interesting properties including higher carrier mobilities than Si, a tuneable lattice constant, and a tuneable bandgap. In previous work, we have demonstrated the ability to form localised areas of single crystal, uniform composition SiGe-on-insulator. Here we present a method of simultaneously growing several areas of SiGe-on-insulator on a single wafer, with the ability to tune the composition of each localised SiGe area, whilst retaining a uniform composition in that area. We use a rapid melt growth technique that comprises of only a single Ge growth step and a single anneal step. This innovative method is key in working towards a fully integrated photonic-electronic platform, enabling the simultaneous growth of multiple compositions of device grade SiGe for electro-absorption optical modulators operating at a range of wavelengths, photodetectors, and bipolar transistors, on the same wafer. This is achieved by modifying the structural design of the SiGe strips, without the need to modify the growth conditions, and by using low cost, low thermal-budget methods.

  13. A flexible home monitoring platform for patients affected by chronic heart failure directly integrated with the remote Hospital Information System

    Science.gov (United States)

    Donati, Massimiliano; Bacchillone, Tony; Saponara, Sergio; Fanucci, Luca

    2011-05-01

    Today Chronic Heart Failure (CHF) represents one of leading cause of hospitalization among chronic disease, especially for elderly citizens, with a consequent considerable impact on patient quality of life, resources congestion and healthcare costs for the National Sanitary System. The current healthcare model is mostly in-hospital based and consists of periodic visits, but unfortunately it does not allow to promptly detect exacerbations resulting in a large number of rehospitalization. Recently physicians and administrators identify telemonitoring systems as a strategy able to provide effective and cost efficient healthcare services for CHF patients, ensuring early diagnosis and treatments in case of necessity. This work presents a complete and integrated ICT solution to improve the management of chronic heart failure through the remote monitoring of vital signs at patient home, able to connect in-hospital care of acute syndrome with out-of-hospital follow-up. The proposed platform represents the patient's interface, acting as link between biomedical sensors and the data collection point at the Hospital Information System (HIS) in order to handle in transparent way the reception, analysis and forwarding of the main physiological parameters.

  14. The EnerGEO Platform of Integrated Assessment (PIA). Environmental assessment of scenarios as a web service

    International Nuclear Information System (INIS)

    With the International Energy Agency estimating that global energy demand will increase between 40 and 50 percent by 2030 (compared to 2003), scientists and policymakers are concerned about the sustainability of the current energy system and what environmental pressures might result from the development of future energy systems. EnerGEO is an ongoing FP7 Project (2009-2013) which assesses the current and future impact of energy use on the environment by linking environmental observation systems with the processes involved in exploiting energy resources. The idea of this European project is to determine how low carbon scenarios, and in particular scenarios with a high share of renewable electricity, affect emissions of air pollutants and greenhouse gases (GHG) and contribute to mitigation of negative energy system impacts on human health and ecosystems. A Platform of Integrated Assessment (PIA) has been elaborated to provide impact results for a selection of scenarios via a set of models (large-scale energy models, Life Cycle Assessment models,..). This PIA is currently available through a web service. The concept of the PIA is detailed and to illustrate its interest, a set of results is given with the use of the simulation mode of the European version of GAINS for a selection of scenarios. (orig.)

  15. Integrating candidate metabolites and biochemical factors to elucidate the action mechanism of Xue-sai-tong injection based on (1)H NMR metabolomics.

    Science.gov (United States)

    Jiang, Miaomiao; Zhao, Xiaoping; Wang, Linli; Xu, Lei; Zhang, Yan; Li, Zheng

    2016-07-15

    A strategy of integrating candidate metabolites with crucial biochemical factors was proposed in this study to discover relevant biological functions for interpreting the action mechanism of Traditional Chinese Medicines (TCM). This approach was applied to Xue-Sai-Tong injection (XST) to reveal the action mechanism based on the metabolic response in an ischemia/reperfusion (I/R) rat model by analyzing NMR profile. Partial least squares discriminate analysis (PLS-DA) was used to compare metabolic profiles of serum samples and revealed nine metabolites altered by I/R injury could be restored to normal status (sham-operated group) under the therapy of XST. The pathway enrichment analysis suggested the metabolic changes were mainly involved in pyruvate metabolism, glycolysis, and citrate cycle. The functional roles of the candidate metabolites were further identified by Pearson correlation analysis with the key biochemical factors in serum. The results indicated pyruvate, succinate, acetate and lysine showed significant associations with the oxidative stress factors. Elevated level of pyruvate was found as an essential metabolic response for the major effect of XST against I/R injury by enhancing glycolysis and overcoming the induced reactive oxygen species (ROS). This metabolomics approach provides a better understanding of the mechanisms of TCM and helps to develop a holistic view of TCM efficacy. PMID:26862062

  16. A New Approach of Electronics and Photonics Convergence on Si CMOS Platform: How to Reduce Device Diversity of Photonics for Integration

    OpenAIRE

    Kazumi Wada

    2008-01-01

    Integrated photonics via Si CMOS technology has been a strategic area since electronics and photonics convergence should be the next platform for information technology. The platform is recently referred to as “Si photonics†that attracts much interest of researchers in industries as well as academia in the world. The main goal of Si Photonics is currently to reduce material diversity of photonic devices to pursuing CMOS-compatibility. In contrast, the present paper proposes another ...

  17. AnyExpress: Integrated toolkit for analysis of cross-platform gene expression data using a fast interval matching algorithm

    Directory of Open Access Journals (Sweden)

    Jung Hyunchul

    2011-03-01

    Full Text Available Abstract Background Cross-platform analysis of gene express data requires multiple, intricate processes at different layers with various platforms. However, existing tools handle only a single platform and are not flexible enough to support custom changes, which arise from the new statistical methods, updated versions of reference data, and better platforms released every month or year. Current tools are so tightly coupled with reference information, such as reference genome, transcriptome database, and SNP, which are often erroneous or outdated, that the output results are incorrect and misleading. Results We developed AnyExpress, a software package that combines cross-platform gene expression data using a fast interval-matching algorithm. Supported platforms include next-generation-sequencing technology, microarray, SAGE, MPSS, and more. Users can define custom target transcriptome database references for probe/read mapping in any species, as well as criteria to remove undesirable probes/reads. AnyExpress offers scalable processing features such as binding, normalization, and summarization that are not present in existing software tools. As a case study, we applied AnyExpress to published Affymetrix microarray and Illumina NGS RNA-Seq data from human kidney and liver. The mean of within-platform correlation coefficient was 0.98 for within-platform samples in kidney and liver, respectively. The mean of cross-platform correlation coefficients was 0.73. These results confirmed those of the original and secondary studies. Applying filtering produced higher agreement between microarray and NGS, according to an agreement index calculated from differentially expressed genes. Conclusion AnyExpress can combine cross-platform gene expression data, process data from both open- and closed-platforms, select a custom target reference, filter out undesirable probes or reads based on custom-defined biological features, and perform quantile-normalization with

  18. Vertical One-Dimensional Photonic Crystal Platforms for Label-Free (Bio)Sensing: Towards Drop-And- Measure Applications

    CERN Document Server

    Barillaro, Giuseppe

    2015-01-01

    In this work, all-silicon, integrated optofluidic platforms, fabricated by electrochemical micromachining technology, making use of vertical, one-dimensional high-aspect- ratio photonic crystals for flow-through (bio)sensing applications are reviewed. The potential of such platforms for point-of-care applications is discussed for both pressure-driven and capillarity- driven operations with reference to refractometry and biochemical sensing.

  19. Multi-level stressor analysis from the DNA/biochemical level to community levels in an urban stream and integrative health response (IHR) assessments.

    Science.gov (United States)

    Lee, Jae Hoon; Kim, Joon Ha; Oh, Hee-Mock; An, Kwang-Guk

    2013-01-01

    The objectives of this study were to identify multi-level stressors at the DNA/biochemical level to the community level in fish in an urban stream and to develop an integrative health response (IHR) model for ecological health diagnosis. A pristine control site (S (c) ) and an impacted site (S (i) ) were selected from among seven pre-screened sites studied over seven years. Various chemical analyses indicated that nutrient enrichment (Nitrogen, Phosphorus) and organic pollution were significantly greater (t > 8.783, p platypus showed that the regression coefficient (b) was 3.012 for the S (i) site and 2.915 for the S (c) site, indicating population skewness in the downstream reach. Community-level health was impaired at the S (i) site based on an index of biological integrity (IBI), and physical habitat modifications were identified by a qualitative habitat evaluation index (QHEI). Overall, the model values for the integrative health response (IHR), developed using the star plot approach, were 3.22 (80.5%) at the S (c) site and 0.74 (18.5%) at the S (i) site, indicating that, overall, ecological health impairments were evident in the urban reach. Our study was based on multi-level approaches using biological organization and the results suggest that there is a pivotal point of linkage between mechanistic understanding and real ecological consequences of environmental stressors. PMID:23043344

  20. Integrated micro-biochemical approach for phytoremediation of cadmium and lead contaminated soils using Gladiolus grandiflorus L cut flower.

    Science.gov (United States)

    Mani, Dinesh; Kumar, Chitranjan; Patel, Niraj Kumar

    2016-02-01

    The potential of vermicompost, elemental sulphur, Thiobacillus thiooxidans and Pseudomonas putida for phytoremediation is well known individually but their integrated approach has not been discovered so far. The present work highlights the consideration of so far overlooked aspects of their integrated treatment by growing the ornamental plant, Gladiolus grandiflorus L in uncontaminated and sewage-contaminated soils (sulphur-deficient alluvial Entisols, pH 7.6-7.8) for phytoremediation of cadmium and lead under pot experiment. Between vermicompost and elemental sulphur, the response of vermicompost was higher towards improvement in the biometric parameters of plants, whereas the response of elemental sulphur was higher towards enhanced bioaccumulation of heavy metals under soils. The integrated treatment (T7: vermicompost 6g and elemental sulphur 0.5gkg(-1) soil and co-inoculation of the plant with T. thiooxidans and P. putida) was found superior in promoting root length, plant height and dry biomass of the plant. The treatment T7 caused enhanced accumulation of Cd up to 6.96 and 6.45mgkg(-1) and Pb up to 22.6 and 19.9mgkg(-1) in corm and shoot, respectively at the contaminated soil. T7 showed maximum remediation efficiency of 0.46% and 0.19% and bioaccumulation factor of 2.92 and 1.21 and uptake of 6.75 and 21.4mgkg(-1) dry biomass for Cd and Pb respectively in the contaminated soil. The integrated treatment T7 was found significant over the individual treatments to promote plant growth and enhance phytoremediation. Hence, authors conclude to integrate vermicompost, elemental sulphur and microbial co-inoculation for the enhanced clean-up of Cd and Pb-contaminated soils. PMID:26615479

  1. Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors

    Directory of Open Access Journals (Sweden)

    Chenjie Fei

    2016-03-01

    as unique biochemical signaling networks.

  2. Monolithically Integrated InGaAs Nanowires on 3D Structured Silicon-on-Insulator as a New Platform for Full Optical Links.

    Science.gov (United States)

    Kim, Hyunseok; Farrell, Alan C; Senanayake, Pradeep; Lee, Wook-Jae; Huffaker, Diana L

    2016-03-01

    Monolithically integrated III-V semiconductors on a silicon-on-insulator (SOI) platform can be used as a building block for energy-efficient on-chip optical links. Epitaxial growth of III-V semiconductors on silicon, however, has been challenged by the large mismatches in lattice constants and thermal expansion coefficients between epitaxial layers and silicon substrates. Here, we demonstrate for the first time the monolithic integration of InGaAs nanowires on the SOI platform and its feasibility for photonics and optoelectronic applications. InGaAs nanowires are grown not only on a planar SOI layer but also on a 3D structured SOI layer by catalyst-free metal-organic chemical vapor deposition. The precise positioning of nanowires on 3D structures, including waveguides and gratings, reveals the versatility and practicality of the proposed platform. Photoluminescence measurements exhibit that the composition of ternary InGaAs nanowires grown on the SOI layer has wide tunability covering all telecommunication wavelengths from 1.2 to 1.8 μm. We also show that the emission from an optically pumped single nanowire is effectively coupled and transmitted through an SOI waveguide, explicitly showing that this work lays the foundation for a new platform toward energy-efficient optical links. PMID:26901448

  3. Abitare Mediterraneo. Integrated approach of a sustainable building management in Mediterranean context: think tanks network sharing an open platform to integrate technological and architectural innovation for low energy building

    OpenAIRE

    Trombadore, Antonella

    2014-01-01

    Abitare Mediterraneo proposes an integrated management action to stimulate the participation of major stakeholders in the built environment revitalization process, fostering the objectives of sustainable project. As open platform of knowledge, the continuous updating of technologies and procedures will redefine a quality-based methodology for integrated conservation of existing buildings: new models and standards of indoor comfort in hot/cold season and a more aware management of the availabl...

  4. Integration of a vision-based tracking platform, visual instruction, and error analysis models for an efficient billiard training system

    Science.gov (United States)

    Shih, Chihhsiong; Hsiung, Pao-Ann; Wan, Chieh-Hao; Koong, Chorng-Shiuh; Liu, Tang-Kun; Yang, Yuanfan; Lin, Chu-Hsing; Chu, William Cheng-Chung

    2009-02-01

    A billiard ball tracking system is designed to combine with a visual guide interface to instruct users for a reliable strike. The integrated system runs on a PC platform. The system makes use of a vision system for cue ball, object ball and cue stick tracking. A least-squares error calibration process correlates the real-world and the virtual-world pool ball coordinates for a precise guidance line calculation. Users are able to adjust the cue stick on the pool table according to a visual guidance line instruction displayed on a PC monitor. The ideal visual guidance line extended from the cue ball is calculated based on a collision motion analysis. In addition to calculating the ideal visual guide, the factors influencing selection of the best shot among different object balls and pockets are explored. It is found that a tolerance angle around the ideal line for the object ball to roll into a pocket determines the difficulty of a strike. This angle depends in turn on the distance from the pocket to the object, the distance from the object to the cue ball, and the angle between these two vectors. Simulation results for tolerance angles as a function of these quantities are given. A selected object ball was tested extensively with respect to various geometrical parameters with and without using our integrated system. Players with different proficiency levels were selected for the experiment. The results indicate that all players benefit from our proposed visual guidance system in enhancing their skills, while low-skill players show the maximum enhancement in skill with the help of our system. All exhibit enhanced maximum and average hit-in rates. Experimental results on hit-in rates have shown a pattern consistent with that of the analysis. The hit-in rate is thus tightly connected with the analyzed tolerance angles for sinking object balls into a target pocket. These results prove the efficiency of our system, and the analysis results can be used to attain an

  5. Integration of the OpenIGTLink Network Protocol for Image-Guided Therapy with the Medical Platform MeVisLab

    OpenAIRE

    Egger, Jan; Tokuda, Junichi; Chauvin, Laurent; Freisleben, Bernd; Nimsky, Christopher; Kapur, Tina; Wells, William

    2013-01-01

    We present the integration of the OpenIGTLink network protocol for image-guided therapy (IGT) with the medical prototyping platform MeVisLab. OpenIGTLink is a new, open, simple and extensible network communication protocol for IGT. The protocol provides a standardized mechanism to connect hardware and software by the transfer of coordinate transforms, images, and status messages. MeVisLab is a framework for the development of image processing algorithms and visualization and interaction metho...

  6. Eclipse Platform Technical Overview

    OpenAIRE

    ALS-NSCORT,

    2003-01-01

    The Eclipse Platform is designed for building integrated development environments (IDEs) that can be used to create applications as diverse as web sites, embedded JavaTM programs, C++ programs, and Enterprise JavaBeansTM. This paper is a general technical introduction to the Eclipse Platform. Part I presents a technical overview of its architecture. Part II is a case study of how the Eclipse Platform was used to build a full-featured Java development environment. 20 pages Provider Notes...

  7. Constructing HSOC data platform

    International Nuclear Information System (INIS)

    HXMT is the only independent space astronomic secondary planet during 2006-2010 in China. Also it is the first independent astronomic secondary planet of China. HSOC, which is the data management sub-system, is the fundamental infrastructure of HXMT's scientific administration center. The data platform is the object of data management sub-system, which is an integrated platform supporting storage, share, exchange, query, statistics and management of data. The paper introduces the meaning and construction of HSOC data platform. (authors)

  8. Multi-Analyte Biosensing -- The Integration of Sensing Elements into a Photolithographically Constructed Hydrogel Based Biosensor Platform

    Science.gov (United States)

    Schmid, Matthew John

    The genome sequencing programs have identified hundreds of thousands of genetic and proteomic targets for which there are presently no ascribed functions. The challenge for researchers now is to characterize them, as well as identify and characterize their natural variants. Historically, this has meant studying each individual target separately. However, due to the recent development of multi-analyte microarray devices, these characterizations can be performed in a combinatorial manner in which a single experiment provides information on thousands of targets at a time. In the past decade, microarray technology has settled in on two major designs. The first entails spotting individual receptor types onto a functionalized glass substrate. This is a simple and inexpensive process; however, due to the limited resolution of the mechanical devices used to do the spotting, the densities of these arrays are relatively low. Moreover, receptor preparation requires substantial time and effort. The second variety of microarray uses photolithographic techniques adapted from the semi-conductor industry to chemically synthesize the receptor elements in situ on the sensing surface. Because lithographic patterning is spatially very precise, these arrays achieve very high densities, with as many as one million features per square centimeter. Although these arrays obviate the necessity for laborious "off chip" probe preparation, they are expensive to produce and are limited to two types of receptors (oligonucleotides and peptides). This dissertation presents the development work performed on a hydrogel-based biosensor platform which provides a high density and low cost alternative to the two aforementioned designs. The array features are fabricated lithographically from a liquid pre-polymer doped with biologically active sensing elements at sizes as small as 50microm. Each of the feature types is uniquely shaped, which enables the features to be mass-produced in batches, pooled

  9. Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment.

    Science.gov (United States)

    Yang, Fu-Chun; Chen, Yi-Lung; Tang, Sen-Lin; Yu, Chang-Ping; Wang, Po-Hsiang; Ismail, Wael; Wang, Chia-Hsiang; Ding, Jiun-Yan; Yang, Cheng-Yu; Yang, Chia-Ying; Chiang, Yin-Ru

    2016-08-01

    Steroid hormones, such as androgens, are common surface-water contaminants. However, literature on the ecophysiological relevance of steroid-degrading organisms in the environment, particularly in anoxic ecosystems, is extremely limited. We previously reported that Steroidobacter denitrificans anaerobically degrades androgens through the 2,3-seco pathway. In this study, the genome of Sdo. denitrificans was completely sequenced. Transcriptomic data revealed gene clusters that were distinctly expressed during anaerobic growth on testosterone. We isolated and characterized the bifunctional 1-testosterone hydratase/dehydrogenase, which is essential for anaerobic degradation of steroid A-ring. Because of apparent substrate preference of this molybdoenzyme, corresponding genes, along with the signature metabolites of the 2,3-seco pathway, were used as biomarkers to investigate androgen biodegradation in the largest sewage treatment plant in Taipei, Taiwan. Androgen metabolite analysis indicated that denitrifying bacteria in anoxic sewage use the 2,3-seco pathway to degrade androgens. Metagenomic analysis and PCR-based functional assays showed androgen degradation in anoxic sewage by Thauera spp. through the action of 1-testosterone hydratase/dehydrogenase. Our integrative 'omics' approach can be used for culture-independent investigations of the microbial degradation of structurally complex compounds where isotope-labeled substrates are not easily available. PMID:26872041

  10. A Novel Laser Direct Writing System Integrated with A&F XXY Alignment Platform for Rapid Fabrication of Flexible Electronics

    Directory of Open Access Journals (Sweden)

    Yi-Kai Liu

    2015-05-01

    Full Text Available In this study, a novel laser direct synthesis and pattering technology is applied in conjunction with an A&F XXY alignment platform to rapidly fabricate flexible conductors on a polymer substrate (polyimide film with designated patterns. In the process, a focused continuous wave green laser was focused onto the polymer substrate that is mounted and directed using the XXY alignment platform. The focused laser energy absorbed by the polymer substrate is used to heat the transparent and particle-free reactive silver ink on the polymer substrate surface. With appropriate programing of the XXY alignment platform motion to control the laser scanning parameters, silver patterns with good electrical conductivity were successfully obtained. This technology can be operated directly at atmospheric pressure and room temperature. It does not require the use of vacuum chamber, oven and photo-mask, etc. Therefore, this novel technology and system offers a new approach to the cost-effective and green fabrication for flexible electronics. The compact size and excellent stability of the XXY alignment platform make the fabrication system even more competitive. In particular, the programmable small radius plane rotation function of the XXY alignment platform provides flexibility in the pattern design with turnings while keeps the uniformity of the resulted micro metal lines.

  11. A Bacterial Analysis Platform: An Integrated System for Analysing Bacterial Whole Genome Sequencing Data for Clinical Diagnostics and Surveillance

    DEFF Research Database (Denmark)

    Thomsen, Martin Christen Frølund; Ahrenfeldt, Johanne; Bellod Cisneros, Jose Luis;

    2016-01-01

    and antimicrobial resistance genes. A short printable report for each sample will be provided and an Excel spreadsheet containing all the metadata and a summary of the results for all submitted samples can be downloaded. The pipeline was benchmarked using datasets previously used to test the...... web-based tools we developed a single pipeline for batch uploading of whole genome sequencing data from multiple bacterial isolates. The pipeline will automatically identify the bacterial species and, if applicable, assemble the genome, identify the multilocus sequence type, plasmids, virulence genes...... platform was developed and made publicly available, providing easy-to-use automated analysis of bacterial whole genome sequencing data. The platform may be of immediate relevance as a guide for investigators using whole genome sequencing for clinical diagnostics and surveillance. The platform is freely...

  12. Clinical Data Center Based on Integration Platform%基于集成平台的临床数据中心

    Institute of Scientific and Technical Information of China (English)

    李玉杰

    2014-01-01

    基于集成平台的完整一体化医院信息系统是目前医院建设和发展的基础工程,医院各系统之间的整合,建立患者主索引、标准字典库和临床数据中心、数据交换平台和数据共享平台,是优化业务流程,提高工作效率,充分体现医院管理和业务特色的重要工作。%The hospital information system established on a complete integration platform is currently the basic project in the hospital information system construction and development. To embody the outstanding characteristics in hospital business management, the important work in information system construction is to optimize business processes and improve work efficiency. This includes integrating different administrative departments and establishing the prime patient index, standardized dictionary database, clinical data center, data exchange platform and data sharing platform.

  13. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  14. Simulating biochemical physics with computers: 1. Enzyme catalysis by phosphotriesterase and phosphodiesterase; 2. Integration-free path-integral method for quantum-statistical calculations

    Science.gov (United States)

    Wong, Kin-Yiu

    We have simulated two enzymatic reactions with molecular dynamics (MD) and combined quantum mechanical/molecular mechanical (QM/MM) techniques. One reaction is the hydrolysis of the insecticide paraoxon catalyzed by phosphotriesterase (PTE). PTE is a bioremediation candidate for environments contaminated by toxic nerve gases (e.g., sarin) or pesticides. Based on the potential of mean force (PMF) and the structural changes of the active site during the catalysis, we propose a revised reaction mechanism for PTE. Another reaction is the hydrolysis of the second-messenger cyclic adenosine 3'-5'-monophosphate (cAMP) catalyzed by phosphodiesterase (PDE). Cyclicnucleotide PDE is a vital protein in signal-transduction pathways and thus a popular target for inhibition by drugs (e.g., ViagraRTM). A two-dimensional (2-D) free-energy profile has been generated showing that the catalysis by PDE proceeds in a two-step SN2-type mechanism. Furthermore, to characterize a chemical reaction mechanism in experiment, a direct probe is measuring kinetic isotope effects (KIEs). KIEs primarily arise from internuclear quantum-statistical effects, e.g., quantum tunneling and quantization of vibration. To systematically incorporate the quantum-statistical effects during MD simulations, we have developed an automated integration-free path-integral (AIF-PI) method based on Kleinert's variational perturbation theory for the centroid density of Feynman's path integral. Using this analytic method, we have performed ab initio pathintegral calculations to study the origin of KIEs on several series of proton-transfer reactions from carboxylic acids to aryl substituted alpha-methoxystyrenes in water. In addition, we also demonstrate that the AIF-PI method can be used to systematically compute the exact value of zero-point energy (beyond the harmonic approximation) by simply minimizing the centroid effective potential.

  15. 平台式惯性/星光组合系统斜置对准方法%The Inclined Aiming Scheme of Inertial-Stellar Integrated Platform

    Institute of Scientific and Technical Information of China (English)

    王常虹; 夏刚; 孟倩

    2011-01-01

    It is a necessary step to align the built-in star sensor of an Inertial-Stellar integrated platform to the selected navigation star. In this paper, an inclined aiming scheme through platform rotation control is provided to realize the pre-launch aiming and error analysis is conducted correspondingly. Finally, effectiveness of the scheme is proved through tests.%采用星敏感器内置于惯性平台方案的惯性/星光组合系统需要在发射时将星敏感器对准目标恒星.提出一种通过控制平台转位实现恒星射前对准的平台斜置对准方案,并开展相应的误差分析,最后通过试验验证了方案的有效性.

  16. A New Approach of Electronics and Photonics Convergence on Si CMOS Platform: How to Reduce Device Diversity of Photonics for Integration

    Directory of Open Access Journals (Sweden)

    Kazumi Wada

    2008-01-01

    Full Text Available Integrated photonics via Si CMOS technology has been a strategic area since electronics and photonics convergence should be the next platform for information technology. The platform is recently referred to as “Si photonics” that attracts much interest of researchers in industries as well as academia in the world. The main goal of Si Photonics is currently to reduce material diversity of photonic devices to pursuing CMOS-compatibility. In contrast, the present paper proposes another route of Si Photonics, reducing diversity of photonic devices. The proposed device unifying functionality of photonics is a microresonator with a pin diode structure that enables the Purcell effect and Franz-Keldysh effect to emit and to modulate light from SiGe alloys.

  17. The GLOBE 3D Genome Platform - towards a novel system-biological paper tool to integrate the huge complexity of genome organization and function.

    Science.gov (United States)

    Knoch, Tobias A; Lesnussa, Michael; Kepper, Nick; Eussen, Hubert B; Grosveld, Frank G

    2009-01-01

    Genomes are tremendous co-evolutionary holistic systems for molecular storage, processing and fabrication of information. Their system-biological complexity remains, however, still largely mysterious, despite immense sequencing achievements and huge advances in the understanding of the general sequential, three-dimensional and regulatory organization. Here, we present the GLOBE 3D Genome Platform a completely novel grid based virtual "paper" tool and in fact the first system-biological genome browser integrating the holistic complexity of genomes in a single easy comprehensible platform: Based on a detailed study of biophysical and IT requirements, every architectural level from sequence to morphology of one or several genomes can be approached in a real and in a symbolic representation simultaneously and navigated by continuous scale-free zooming within a unique three-dimensional OpenGL and grid driven environment. In principle an unlimited number of multi-dimensional data sets can be visualized, customized in terms of arrangement, shape, colour, and texture etc. as well as accessed and annotated individually or in groups using internal or external data bases/facilities. Any information can be searched and correlated by importing or calculating simple relations in real-time using grid resources. A general correlation and application platform for more complex correlative analysis and a front-end for system-biological simulations both using again the huge capabilities of grid infrastructures is currently under development. Hence, the GLOBE 3D Genome Platform is an example of a grid based approach towards a virtual desktop for genomic work combining the three fundamental distributed resources: i) visual data representation, ii) data access and management, and iii) data analysis and creation. Thus, the GLOBE 3D Genome Platform is the novel system-biology oriented information system urgently needed to access, present, annotate, and to simulate the holistic genome

  18. Temperature profiles from expendable bathythermograph (XBT) casts from the BARTLETT and Other Platforms in the North Pacific Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 14 March 1974 to 04 May 1974 (NODC Accession 7400432)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the BARTLETT and Other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data were collected by the...

  19. Systematic Integration of Innovation in Process Improvement Projects Using the Enhanced Sigma-TRIZ Algorithm and Its Effective Use by Means of a Knowledge Management Software Platform

    Directory of Open Access Journals (Sweden)

    Mircea FULEA

    2009-01-01

    Full Text Available In an evolving, highly turbulent and uncertain socio-economic environment, organizations must consider strategies of systematic and continuous integration of innovation within their business systems, as a fundamental condition for sustainable development. Adequate methodologies are required in this respect. A mature framework for integrating innovative problem solving approaches within business process improvement methodologies is proposed in this paper. It considers a TRIZ-centred algorithm in the improvement phase of the DMAIC methodology. The new tool is called enhanced sigma-TRIZ. A case study reveals the practical application of the proposed methodology. The integration of enhanced sigma-TRIZ within a knowledge management software platform (KMSP is further described. Specific developments to support processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application in a friendly and effective way within the KMSP are also highlighted.

  20. Light coupling between vertical III-As nanowires and planar Si photonic waveguides for the monolithic integration of active optoelectronic devices on a Si platform.

    Science.gov (United States)

    Giuntoni, Ivano; Geelhaar, Lutz; Bruns, Jürgen; Riechert, Henning

    2016-08-01

    We present a new concept for the optical interfacing between vertical III-As nanowires and planar Si waveguides. The nanowires are arranged in a two-dimensional array which forms a grating structure on top of the waveguide. This grating enables light coupling in both directions between the components made from the two different material classes. Numerical simulations show that this concept permits a light extraction efficiency from the waveguide larger than 45% and a light insertion efficiency larger than 35%. This new approach would allow the monolithic integration of nanowire-based active optoelectronics devices, like photodetectors and light sources, on the Si photonics platform. PMID:27505805

  1. Contribution to global computation infrastructure: inter-platform delegation, integration of standard services and application to high-energy physics

    International Nuclear Information System (INIS)

    The generalization and implementation of the current information resources, particularly the large storing capacities and the networks allow conceiving new methods of work and ways of entertainment. Centralized stand-alone, monolithic computing stations have been gradually replaced by distributed client-tailored architectures which in turn are challenged by the new distributed systems called 'pair-by pair' systems. This migration is no longer with the specialists' realm but users of more modest skills get used with this new techniques for e-mailing commercial information and exchanging various sorts of files on a 'equal-to-equal' basis. Trade, industry and research as well make profits largely of the new technique called 'grid', this new technique of handling information at a global scale. The present work concerns the grid utilisation for computation. A synergy was created with Paris-Sud University at Orsay, between the Information Research Laboratory (LRI) and the Linear Accelerator Laboratory (LAL) in order to foster the works on grid infrastructure of high research interest for LRI and offering new working methods for LAL. The results of the work developed within this inter-disciplinary-collaboration are based on XtremWeb, the research and production platform for global computation elaborated at LRI. First one presents the current status of the large-scale distributed systems, their basic principles and user-oriented architecture. The XtremWeb is then described focusing the modifications which were effected upon both architecture and implementation in order to fulfill optimally the requirements imposed to such a platform. Then one presents studies with the platform allowing a generalization of the inter-grid resources and development of a user-oriented grid adapted to special services, as well,. Finally one presents the operation modes, the problems to solve and the advantages of this new platform for the high-energy research community, the most demanding

  2. Supplementary immunization activities (SIAs) in South Africa: comprehensive economic evaluation of an integrated child health delivery platform

    OpenAIRE

    Verguet, Stéphane; Jassat, Waasila; Bertram, Melanie Y.; Tollman, Stephen M; Murray, Christopher J. L; Jamison, Dean T.; Hofman, Karen J.

    2013-01-01

    Background: Supplementary immunization activity (SIA) campaigns provide children with an additional dose of measles vaccine and deliver other interventions, including vitamin A supplements, deworming medications, and oral polio vaccines.Objective: To assess the cost-effectiveness of the full SIA delivery platform in South Africa (SA). Design: We used an epidemiologic cost model to estimate the cost-effectiveness of the 2010 SIA campaign. We used province-level campaign data sourced from the D...

  3. Closing the treatment gap for mental, neurological and substance use disorders by strengthening existing health care platforms: strategies for delivery and integration of evidence-based interventions.

    Science.gov (United States)

    Shidhaye, Rahul; Lund, Crick; Chisholm, Dan

    2015-01-01

    This paper outlines the main elements and features of a mental health care delivery platform and its delivery channels. These include evidence-based interventions that can be delivered via this platform as well as broader health system strengthening strategies for more effective and efficient delivery of services. The focus is broadly on health systems perspective rather than strictly disorder-oriented intervention analysis. A set of evidence-based interventions within the WHO pyramid framework of self-care, primary care, and specialist care have been identified; the main challenge lies in the translation of that evidence into practice. The delivery of these interventions requires an approach that puts into practice key principles of public health, adopts systems thinking, promotes whole-of-government involvement and is focused on quality improvement. Key strategies for effective translation of evidence into action include collaborative stepped care, strengthening human resources, and integrating mental health into general health care. In order to pursue these principles and strategies using a platform-wide approach, policy makers need to engage with a wide range of stakeholders and make use of the best available evidence in a transparent manner. PMID:26719762

  4. Organochlorines and metals induce changes in the mitochondria-rich cells of fish gills: an integrative field study involving chemical, biochemical and morphological analyses.

    Science.gov (United States)

    Fernandes, M N; Paulino, M G; Sakuragui, M M; Ramos, C A; Pereira, C D S; Sadauskas-Henrique, H

    2013-01-15

    Through integrating chemical, biochemical and morphological analyses, this study investigated the effects of multiple pollutants on the gill mitochondria-rich cells (MRCs) in two fish species, Astyanax fasciatus and Pimelodus maculatus, collected from five sites (FU10, FU20, FU30, FU40 and FU50) in the Furnas Hydroelectric Power Station reservoir. Water analyses revealed aluminum, iron and zinc as well as organochlorine (aldrin/dieldrin, endosulfan, heptachlor/heptachlor epoxide and metolachlor) contamination at all of the sites, with the exception of FU10. Copper, chrome, iron and zinc were detected in the gills of both species, and aldrin/dieldrin, endosulfan and heptachlor/heptachlor epoxide were detected in the gills of fish from all of the sites, with the exception of FU10. Fish collected at FU20, FU30 and FU50 exhibited numerous alterations in the surface architecture of their pavement cells and MRCs. The surface MRC density and MRC fractional area were lower in fish from FU20, FU30, FU40 and FU50 than in those from the reference site (FU10) in the winter, and some variability between the sites was observed in the summer. The organochlorine contamination at FU20 and FU50 was associated with variable changes in the MRCs and inhibition of Na(+)/K(+)-ATPase (NKA) activity, especially in P. maculatus. At FU30, the alterations in the MRCs were associated with the contaminants present, especially metals. A multivariate analysis demonstrated a positive association between the biological responses of both species and environmental contamination, indicating that under realistic conditions, a mixture of organochlorines and metals affected the MRCs by inhibiting NKA activity and inducing morphological changes, which may cause an ionic imbalance. PMID:23220410

  5. Design and Simulation of Material-Integrated Distributed Sensor Processing with a Code-Based Agent Platform and Mobile Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Stefan Bosse

    2015-02-01

    Full Text Available Multi-agent systems (MAS can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  6. Process integration and economic analysis of bio-oil platform for the production of methanol and combined heat and power

    OpenAIRE

    Ng, KS; Sadhukhan, J

    2011-01-01

    Process to process material and heat integration strategies for bio-oil integrated gasification and methanol synthesis (BOIG-MeOH) systems were developed to assess their technological and economic feasibility. Distributed bio-oil generations and centralised processing enhance resource flexibility and technological feasibility. Economic performance depends on the integration of centralised BOIG-MeOH processes, investigated for cryogenic air separation unit (ASU) and water electrolyser configur...

  7. Integrated Physiological, Biochemical, and Molecular Analysis Identifies Important Traits and Mechanisms Associated with Differential Response of Rice Genotypes to Elevated Temperature

    OpenAIRE

    Sailaja, Boghireddy; Subrahmanyam, Desiraju; Neelamraju, Sarla; Vishnukiran, Turaga; Rao, Yadavalli Venkateswara; Vijayalakshmi, Pujarula; Voleti, Sitapati R.; Bhadana, Vijai P.; Mangrauthia, Satendra K.

    2015-01-01

    In changing climatic conditions, heat stress caused by high temperature poses a serious threat to rice cultivation. A multiple organizational analysis at physiological, biochemical, and molecular levels is required to fully understand the impact of elevated temperature in rice. This study was aimed at deciphering the elevated temperature response in 11 popular and mega rice cultivars widely grown in India. Physiological and biochemical traits specifically membrane thermostability (MTS), antio...

  8. Thermo-Economic Modelling and Process Integration of CO2-Mitigation Options on Oil and Gas Platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Tock, Laurence; Breuhaus, Peter;

    2014-01-01

    The offshore extraction of oil and gas is an energy-intensive process associated with large CO2 and CH4 emissions to the atmosphere and chemicals to the sea. The taxation of these emissions has encouraged the development of more energy-efficient and environmental-friendly solutions, of which three...... are assessed in this paper. The integration of steam bottoming cycles on the gas turbines or of lowtemperature power cycles on the export gas compression can result either in an additional power output, or in a greater export of natural gas. Another possibility is to implement a CO2-capture unit......, which allows recovering CO2 that can be used for enhanced oil recovery. In this paper, a North Sea platform is considered as case study, and the site-scale retrofit integration of these three options is analysed, considering thermodynamic, economic and environmental performance indicators. The results...

  9. X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection

    International Nuclear Information System (INIS)

    The X-CHIP (X-ray Crystallography High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The X-CHIP (X-ray Crystallization High-throughput Integrated Platform) is a novel microchip that has been developed to combine multiple steps of the crystallographic pipeline from crystallization to diffraction data collection on a single device to streamline the entire process. The system has been designed for crystallization condition screening, visual crystal inspection, initial X-ray screening and data collection in a high-throughput fashion. X-ray diffraction data acquisition can be performed directly on-the-chip at room temperature using an in situ approach. The capabilities of the chip eliminate the necessity for manual crystal handling and cryoprotection of crystal samples, while allowing data collection from multiple crystals in the same drop. This technology would be especially beneficial for projects with large volumes of data, such as protein-complex studies and fragment-based screening. The platform employs hydrophilic and hydrophobic concentric ring surfaces on a miniature plate transparent to visible light and X-rays to create a well defined and stable microbatch crystallization environment. The results of crystallization and data-collection experiments demonstrate that high-quality well diffracting crystals can be grown and high-resolution diffraction data sets can be collected using this technology. Furthermore, the quality of a single-wavelength anomalous dispersion data set collected with the X-CHIP at room temperature was sufficient to generate interpretable electron-density maps. This technology is highly resource-efficient owing to the use of nanolitre-scale drop volumes. It does not require any modification for most in-house and synchrotron beamline systems and offers

  10. A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

    Science.gov (United States)

    Eissing, Thomas; Kuepfer, Lars; Becker, Corina; Block, Michael; Coboeken, Katrin; Gaub, Thomas; Goerlitz, Linus; Jaeger, Juergen; Loosen, Roland; Ludewig, Bernd; Meyer, Michaela; Niederalt, Christoph; Sevestre, Michael; Siegmund, Hans-Ulrich; Solodenko, Juri; Thelen, Kirstin; Telle, Ulrich; Weiss, Wolfgang; Wendl, Thomas; Willmann, Stefan; Lippert, Joerg

    2011-01-01

    Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multiscale by nature, project work, and software tools usually focus on isolated aspects of drug action, such as pharmacokinetics at the organism scale or pharmacodynamic interaction on the molecular level. We present a modeling and simulation software platform consisting of PK-Sim® and MoBi® capable of building and simulating models that integrate across biological scales. A prototypical multiscale model for the progression of a pancreatic tumor and its response to pharmacotherapy is constructed and virtual patients are treated with a prodrug activated by hepatic metabolization. Tumor growth is driven by signal transduction leading to cell cycle transition and proliferation. Free tumor concentrations of the active metabolite inhibit Raf kinase in the signaling cascade and thereby cell cycle progression. In a virtual clinical study, the individual therapeutic outcome of the chemotherapeutic intervention is simulated for a large population with heterogeneous genomic background. Thereby, the platform allows efficient model building and integration of biological knowledge and prior data from all biological scales. Experimental in vitro model systems can be linked with observations in animal experiments and clinical trials. The interplay between patients, diseases, and drugs and topics with high clinical relevance such as the role of pharmacogenomics, drug–drug, or drug–metabolite interactions can be addressed using this mechanistic, insight driven multiscale modeling approach. PMID:21483730

  11. A computational systems biology software platform for multiscale modeling and simulation: Integrating whole-body physiology, disease biology, and molecular reaction networks

    Directory of Open Access Journals (Sweden)

    Thomas eEissing

    2011-02-01

    Full Text Available Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multi-scale by nature, project work and software tools usually focus on isolated aspects of drug action, such as pharmacokinetics at the organism scale or pharmacodynamic interaction on the molecular level. We present a modeling and simulation software platform consisting of PK-Sim® and MoBi® capable of building and simulating models that integrate across biological scales. A prototypical multiscale model for the progression of a pancreatic tumor and its response to pharmacotherapy is constructed and virtual patients are treated with a prodrug activated by hepatic metabolization. Tumor growth is driven by signal transduction leading to cell cycle transition and proliferation. Free tumor concentrations of the active metabolite inhibit Raf kinase in the signaling cascade and thereby cell cycle progression. In a virtual clinical study, the individual therapeutic outcome of the chemotherapeutic intervention is simulated for a large population with heterogeneous genomic background. Thereby, the platform allows efficient model building and integration of biological knowledge and prior data from all biological scales. Experimental in vitro model systems can be linked with observations in animal experiments and clinical trials. The interplay between patients, diseases, and drugs and topics with high clinical relevance such as the role of pharmacogenomics, drug-drug or drug-metabolite interactions can be addressed using this mechanistic, insight driven multiscale modeling approach.

  12. Transition to a novel advanced integrated vitrectomy platform: comparison of the surgical impact of moving from the Accurus vitrectomy platform to the Constellation Vision System for microincisional vitrectomy surgery

    Directory of Open Access Journals (Sweden)

    Murray TG

    2013-02-01

    underwent MIVS during the 2-year study windows, with 281 patients undergoing surgery with the Accurus system and 233 patients undergoing surgery with the Constellation system. Combined MIVS and phacoemulsification with IOL implantation was performed 141 times during this period with the Accurus and 158 times during the second study period with the Constellation. Total number of patients operated per day increased from 7.55 with Accurus to 8.53 with Constellation. Surgical room time decreased from 56 minutes with Accurus to 52 minutes with Constellation, and procedure time decreased from 35 minutes with Accurus to 31 minutes with Constellation (P < 0.004. Combined MIVS/phacoemulsification surgery saw similar declines in surgical room time and procedure time (P < 0.001. Subset analysis of procedures limited by case number per day (eg, four cases/day, five cases/day, six cases/day, and seven or more cases/day showed similar outcomes with a decrease in surgical room time and procedure time. No increases in surgery-related complications were noted by quality assurance review during these time periods.Discussion: Transitioning to advanced surgical technology is a complex issue for the surgeon, the hospital team, and the hospital administration. This study documents improvement in three significant measures of surgical efficiency: operative number of patients per day, operative room time, and surgical procedure time that reflect the positive impact of the novel, combined, integrated, posterior and anterior, ophthalmologic surgical platform of the Constellation Vision System. These data are imperative to evaluate the impact of transition from one surgical platform to another. During this transition, hospital quality assurance review and surgeon evaluation of operative complications showed no increased concerns for the shift from the Accurus to the Constellation Vision System surgical platform. Further, both operative staff and surgeons felt that the transition to the Constellation

  13. 集成VISSIM、Excel VBA和MATLAB的仿真平台研究%Integrated Simulation Platform of VISSIM, Excel VBA, MATLAB

    Institute of Scientific and Technical Information of China (English)

    卢守峰; 韦钦平; 沈文; 刘喜敏

    2012-01-01

    The paper puts forward an integration method of Excel VBA, VISSIM and MATLAB for traffic simulation platform, which indeed solve the problem of programming difficulty and time consuming if the high-level programming language is used to re-program. The Excel VBA is the master control program. Excel VBA has the easy interface programming with VISSIM and MATLAB. The MATLAB has the powerful toolbox, library function and the advantages of analyzing the matrix. The VISSIM and MATLAB are the called objects of Excel VBA.VISSIM usually simulates traffic flow and outputs the performance index.MATLAB is programmed for the proposed traffic control model.The integration of VISSIM and Excel is realized by the COM data commumication interface.The integration of Excel and MATLAB is realized by the Excel Link extension interface.The proposed integration method for traffic control simulatio platform provides an effective solution to validate the traffic control model.The paper also presents an example of Q-learning signal timing optimization based on the proposed traffic control simulation platform.%本文提出了利用Excel VBA作为主控程序将VISSIM与MATLAB进行集成构建仿真平台的方法,解决了直接对VISSIM二次开发编程难度大、耗时长的问题.该方法综合Excel VBA与VISSIM、MATLAB的接口编程容易,且MATLAB具有强大的工具箱、库函数和擅长处理矩阵的优点,其中VISSIM和MATLAB作为Excel VBA的调用对象,利用MATLAB编制新建交通控制模型的代码,利用VISSIM模拟车流运行和提取各种交通运行性能指标.具体地,VISSIM与Excel之间采用COM数据通讯接口进行集成,Excel与MATLAB之间采用Excel Link扩展接口进行集成.采用这种方法建立的交通控制仿真平台为研究验证新型的交通控制模型提供了有效途径,最后给出了一个基于该控制仿真平台建立的Q学习配时优化模型的实例.

  14. Beyond xMOOCs in healthcare education: study of the feasibility in integrating virtual patient systems and MOOC platforms

    OpenAIRE

    Natalia Stathakarou; Nabil Zary; Kononowicz, Andrzej A.

    2014-01-01

    Background. Massive Open Online Courses (MOOCs) are an emerging trend in online learning. However, their technology is not yet completely adjusted to the needs of healthcare education. Integration of Virtual Patients within MOOCs to increase interactivity and foster clinical reasoning skills training, has been discussed in the past, but not verified by a practical implementation. Objective. To investigate the technical feasibility of integrating MOOCs with Virtual Patients for the purpose...

  15. Case Study of Integrating an Offshore Wind Farm with Offshore Oil and Gas Platforms and with an Onshore Electrical Grid

    Directory of Open Access Journals (Sweden)

    Wei He

    2013-01-01

    Full Text Available This research project explored the technical feasibility of utilizing an offshore wind farm as a supplementary power source to several electrical grids of offshore oil and gas platforms and providing surplus power to an onshore grid. Three case studies comprising wind farms rated at 20 MW, 100 MW, and 1000 MW have been studied with the focus on (i the operation benefits of CO2/NOx emission reduction, (ii the electrical grid stability, and (iii the technical implementation feasibility. The proposed 20 MW, 100 MW, and 1000 MW wind farm cases are theoretically feasible in terms of the selected technical criteria, although further detailed design operational studies, and economical analysis are required.

  16. All-optical SR flip-flop based on SOA-MZI switches monolithically integrated on a generic InP platform

    Science.gov (United States)

    Pitris, St.; Vagionas, Ch.; Kanellos, G. T.; Kisacik, R.; Tekin, T.; Broeke, R.; Pleros, N.

    2016-03-01

    At the dawning of the exaflop era, High Performance Computers are foreseen to exploit integrated all-optical elements, to overcome the speed limitations imposed by electronic counterparts. Drawing from the well-known Memory Wall limitation, imposing a performance gap between processor and memory speeds, research has focused on developing ultra-fast latching devices and all-optical memory elements capable of delivering buffering and switching functionalities at unprecedented bit-rates. Following the master-slave configuration of electronic Flip-Flops, coupled SOA-MZI based switches have been theoretically investigated to exceed 40 Gb/s operation, provided a short coupling waveguide. However, this flip-flop architecture has been only hybridly integrated with silica-on-silicon integration technology exhibiting a total footprint of 45x12 mm2 and intra-Flip-Flop coupling waveguide of 2.5cm, limited at 5 Gb/s operation. Monolithic integration offers the possibility to fabricate multiple active and passive photonic components on a single chip at a close proximity towards, bearing promises for fast all-optical memories. Here, we present for the first time a monolithically integrated all-optical SR Flip-Flop with coupled master-slave SOA-MZI switches. The photonic chip is integrated on a 6x2 mm2 die as a part of a multi-project wafer run using library based components of a generic InP platform, fiber-pigtailed and fully packaged on a temperature controlled ceramic submount module with electrical contacts. The intra Flip-Flop coupling waveguide is 5 mm long, reducing the total footprint by two orders of magnitude. Successful flip flop functionality is evaluated at 10 Gb/s with clear open eye diagram, achieving error free operation with a power penalty of 4dB.

  17. Exploration on Building the Resource Integration Platforms of College Students' Entrepreneurship Service%搭建大学生创业服务的资源整合平台的探索

    Institute of Scientific and Technical Information of China (English)

    李凯

    2014-01-01

    This paper analyzes the main problems existing in the resource integration of the college students' entrepreneurship service, such as lack of policy effectiveness, lack of resources coordination. Guided by the demands of college students "users", this paper explores to build the six resource integration platforms of the college students' dntrepreneurship, such as policy service platform, course platform, project cultivation platform, human resources platform, financing platform, consulting service platform, to promote college students' entrepreneurship.%本文分析了当前大学生创业服务的资源整合方面存在的政策实效不足,资源协调不够等问题。以大学生“用户”需求为导向,探索搭建大学生创业服务资源整合的政策服务平台、课程平台、项目培育平台、人力资源平台、融资平台、服务咨询平台等六大平台,促进大学生创业。

  18. An extensible web interface for databases and its application to storing biochemical data

    CERN Document Server

    Angelopoulos, Nicos

    2010-01-01

    This paper presents a generic web-based database interface implemented in Prolog. We discuss the advantages of the implementation platform and demonstrate the system's applicability in providing access to integrated biochemical data. Our system exploits two libraries of SWI-Prolog to create a schema-transparent interface within a relational setting. As is expected in declarative programming, the interface was written with minimal programming effort due to the high level of the language and its suitability to the task. We highlight two of Prolog's features that are well suited to the task at hand: term representation of structured documents and relational nature of Prolog which facilitates transparent integration of relational databases. Although we developed the system for accessing in-house biochemical and genomic data the interface is generic and provides a number of extensible features. We describe some of these features with references to our research databases. Finally we outline an in-house library that...

  19. EarthScope's Plate Boundary Observatory in Alaska: Building on Existing Infrastructure to Provide a Platform for Integrated Research and Hazard-monitoring Efforts

    Science.gov (United States)

    Boyce, E. S.; Bierma, R. M.; Willoughby, H.; Feaux, K.; Mattioli, G. S.; Enders, M.; Busby, R. W.

    2014-12-01

    EarthScope's geodetic component in Alaska, the UNAVCO-operated Plate Boundary Observatory (PBO) network, includes 139 continuous GPS sites and 41 supporting telemetry relays. These are spread across a vast area, from northern AK to the Aleutians. Forty-five of these stations were installed or have been upgraded in cooperation with various partner agencies and currently provide data collection and transmission for more than one group. Leveraging existing infrastructure normally has multiple benefits, such as easier permitting requirements and costs savings through reduced overall construction and maintenance expenses. At some sites, PBO-AK power and communications systems have additional capacity beyond that which is needed for reliable acquisition of GPS data. Where permits allow, such stations could serve as platforms for additional instrumentation or real-time observing needs. With the expansion of the Transportable Array (TA) into Alaska, there is increased interest to leverage existing EarthScope resources for station co-location and telemetry integration. Because of the complexity and difficulty of long-term O&M at PBO sites, however, actual integration of GPS and seismic equipment must be considered on a case-by-case basis. UNAVCO currently operates two integrated GPS/seismic stations in collaboration with the Alaska Earthquake Center, and three with the Alaska Volcano Observatory. By the end of 2014, PBO and TA plan to install another four integrated and/or co-located geodetic and seismic systems. While three of these are designed around existing PBO stations, one will be a completely new TA installation, providing PBO with an opportunity to expand geodetic data collection in Alaska within the limited operations and maintenance phase of the project. We will present some of the design considerations, outcomes, and lessons learned from past and ongoing projects to integrate seismometers and other instrumentation at PBO-Alaska stations. Developing the PBO

  20. MathWorks Simulink and C++ integration with the new VLT PLC-based standard development platform for instrument control systems

    Science.gov (United States)

    Kiekebusch, Mario J.; Di Lieto, Nicola; Sandrock, Stefan; Popovic, Dan; Chiozzi, Gianluca

    2014-07-01

    ESO is in the process of implementing a new development platform, based on PLCs, for upcoming VLT control systems (new instruments and refurbishing of existing systems to manage obsolescence issues). In this context, we have evaluated the integration and reuse of existing C++ libraries and Simulink models into the real-time environment of BECKHOFF Embedded PCs using the capabilities of the latest version of TwinCAT software and MathWorks Embedded Coder. While doing so the aim was to minimize the impact of the new platform by adopting fully tested solutions implemented in C++. This allows us to reuse the in house expertise, as well as extending the normal capabilities of the traditional PLC programming environments. We present the progress of this work and its application in two concrete cases: 1) field rotation compensation for instrument tracking devices like derotators, 2) the ESO standard axis controller (ESTAC), a generic model-based controller implemented in Simulink and used for the control of telescope main axes.

  1. Research on marketing-distribution-dispatching integration platform and its key technologies%营配调一体化平台及其关键技术研究

    Institute of Scientific and Technical Information of China (English)

    郝思鹏; 楚成彪; 方泉; 胡瑞梅; 张俊

    2014-01-01

    针对配电网信息共享和应用集成需要,构建了营配调一体化平台。将平台分为基础层、支撑平台层、应用层,基础层基于公共信息模型和接口规范提供统一的数据基础;支撑平台层根据业务需求进行对象聚合,建立共享融合平台和实时数据平台,为其它平台提供信息;应用层基于跨平台的数据开发高级应用。在此基础上,对一体化平台的聚合对象技术、实时数据接入技术、空间信息技术进行研究。最后,在营配调一体化平台上进行了高级应用的开发,并在示范工程中取得了良好的运行效果。%Aiming at the demand of information sharing and application integration of power distribution network, a marketing-distribution-dispatching integration platform is established, which is composed by base layer, supportting platform layer, and application layer.The base layer provides uniform data based on common information model and uniform interface specification.The supporting platform layer aggregates objects according to the needs of the busi-ness, as well as establishes shared integration platform and real time data platform.It provides information for other platforms.The application layer develops advanced applications based on the data from cross-layer platform.The ag-gregate object technology, real-time-data access technology and geographic information technology of integrated plat-form are researched to support integration platform.Finally, advanced application based on integration platform is de-veloped.It achieves good operating effect in the demonstration project.

  2. Ricebase: a breeding and genetics platform for rice, integrating individual molecular markers, pedigrees, and whole-genome-based data

    Science.gov (United States)

    Ricebase (http://ricebase.org) is an integrative genomic database for rice (Oryza sativa) with an emphasis on combining data sets in a way that maintains the key links between past and current genetic studies. Ricebase includes DNA sequence data, gene annotations, nucleotide variation data, and mol...

  3. The Requirement Analysis of the Provincial IPTV Integrated Broadcast Control Platform%省级广电IPTV集成播控平台的需求分析

    Institute of Scientific and Technical Information of China (English)

    李文皓

    2013-01-01

    The main features of Internet Protocol Television ( IPTV ) in its interactive capabilities and real-time , select IPTV service , allows users to get high-quality digital media services , real interaction between con-sumers and carriers .In recent years , with the development of IPTV industry , integrated broadcast control plat-form system came into being .The system will use radio and television is responsible for broadcast control , tele-com operators responsible for the transmission of mode , the control and management functions of the provincial radio and television operators to complete the broadcast content , specifically responsible for program manage-ment, authorization control, cost-recovery, user management.The project is part of the complete structure of China triple play content broadcast control , integrated broadcast control platform is the only IPTV content in the provincial areas .Above it connected to the national IPTV central integrated broadcast control total platform integration of all levels of media units and other content providers in the area of this province , the bottom con-nected to the provincial company of China Telecom IPTV content distribution platform and transmission net -work to provide live with Taiwanese characteristics , Carousel , on-demand video program content and network services.%IPTV的主要特点在于其交互能力和实时性,选择IPTV业务,可以让用户得到高品质的数字媒体服务,实现消费者和运营商之间真正的互动。近年来随着IPTV产业的大发展,集成播控平台系统应运而生。该系统采用广电负责播控、电信负责传输的运营模式,各省级广电机构完成内容播出的控制和管理功能,具体负责节目管理、授权控制、费用收取、用户管理等工作。该项目是我国三网融合内容播控完整结构的组成部分,是各省级地区唯一的IPTV内容集成播控平台。它上方连接国家IPTV中央集成播控总平

  4. An integrated approach for enhanced protein conjugation and capture with viral nanotemplates and hydrogel microparticle platforms via rapid bioorthogonal reactions.

    Science.gov (United States)

    Jung, Sukwon; Yi, Hyunmin

    2014-07-01

    We demonstrate significantly enhanced protein conjugation and target protein capture capacity by exploiting tobacco mosaic virus (TMV) templates assembled with hydrogel microparticles. Protein conjugation results with a red fluorescent protein R-Phycoerythrin (R-PE) show significantly enhanced protein conjugation capacity of TMV-assembled particles (TMV-particles) compared to planar substrates or hydrogel microparticles. In-depth examination of protein conjugation kinetics via tetrazine (Tz)-trans-cyclooctene (TCO) cycloaddition and strain-promoted alkyne-azide cycloaddition (SPAAC) reaction demonstrates that TMV-particles provide a less hindered environment for protein conjugation. Target protein capture results using an anti-R-PE antibody (R-Ab)-R-PE pair also show substantially improved capture capacity of R-Ab conjugated TMV-particles over R-Ab conjugated hydrogel microparticles. We further demonstrate readily controlled protein and antibody conjugation capacity by simply varying TMV concentrations, which show negligible negative impact of densely assembled TMVs on protein conjugation and capture capacity. Combined, these results illustrate a facile postfabrication protein conjugation approach with TMV templates assembled onto hydrogel microparticles for improved and controlled protein conjugation and sensing platforms. We anticipate that our approach can be readily applied to various protein sensing applications. PMID:24937661

  5. Operating Protocol and Networking Issues of a Telemedicine Platform Integrating from Wireless Home Sensors to the Hospital Information System

    Directory of Open Access Journals (Sweden)

    Massimiliano Donati

    2013-01-01

    Full Text Available Chronic heart failure (CHF is among the major causes of hospitalization for elderly citizens. Its considerable impact on patient quality of life, the resources congestion, and the related costs can be efficiently mitigated using remote wireless biosensors networks placed at patient home, able to communicate in secure way over the public Internet with the cardiology departmental Hospital Information System (HIS. In this way, physicians can monitor the situation of several patients at distance and quickly realize and act alterations in vital parameters. In this scenario, the Health@Home (H@H platform is conceived. The pool of Bluetooth sensors enables patients to daily collect vital signs at home in noninvasive fashion. A home gateway receives and processes all signals before sending them to a server node in charge of interfacing with the usual HIS. The novel concept of operating protocol (OP represents a list of actions, remotely configurable, that the domestic network has to follow (required measurements, transmissions, comparisons with personalized thresholds, etc.. The first medical tests on 30 patients (1 month allowed to verify the model, both from the patient and the medical perspective. The main evaluation metrics were usability, flexibility, and reliability of the communication from sensors to HIS.

  6. An integrated platform for directly widely-targeted quantitative analysis of feces part II: An application for steroids, eicosanoids, and porphyrins profiling.

    Science.gov (United States)

    Song, Yuelin; Song, Qingqing; Li, Jun; Zheng, Jiao; Li, Chun; Zhang, Yuan; Zhang, Lingling; Jiang, Yong; Tu, Pengfei

    2016-08-19

    Steroids, especially bile acids, along with eicosanoids and porphyrins in feces play pivotal roles for the clinical diagnosis of various diseases. However, their reliable measurement is extensively obstructed by poor stability, structural diversity, broad content ranges, and tedious sample preparation protocols that account for a majority of the measurement errors. In current study, in-depth component screening was initially carried out by flexibly integrating diverse modes, such as predefined multiple reaction monitoring, stepped multiple ion monitoring, neutral loss scan, and precursor ion scan on a hybrid triple quadrupole-linear ion trap mass spectrometer, which also provided MS(2) spectra via enhanced product ion experiments. Meanwhile, a hybrid ion trap-time of flight mass spectrometer served as a complementary tool by providing accurate mass spectral information. Afterwards, because authentic compounds were unavailable for most analytes, an online optimization strategy was then proposed to optimize parameters, including precursor-to-product ion transitions and spectrometric parameters, notably collision energy. Finally, direct analysis of all detected components in feces was carried out by employing a platform integrating online pressurized liquid extraction, turbulent flow chromatography, and LC-MS/MS, and applying those optimized parameters. Seventy-one compounds, including 52 steroids and 13 eicosanoids, together with 6 porphyrins, were found and annotated in a fecal pool, and then relatively quantified in various fecal matrices. The quantitative dataset was subjected for multivariate statistical analysis and significant differences were observed among the quantitative chemome profiles of the fecal matrices from different groups. The findings obtained in the two parts demonstrated that the analytical platform in combination with the work-flow is qualified for not only directly simultaneous measurement of diverse endogenous substances, but widely targeted

  7. Pressure-driven mesofluidic platform integrating automated on-chip renewable micro-solid-phase extraction for ultrasensitive determination of waterborne inorganic mercury.

    Science.gov (United States)

    Portugal, Lindomar A; Laglera, Luis M; Anthemidis, Aristidis N; Ferreira, Sérgio L C; Miró, Manuel

    2013-06-15

    A dedicated pressure-driven mesofluidic platform incorporating on-chip sample clean-up and analyte preconcentration is herein reported for expedient determination of trace level concentrations of waterborne inorganic mercury. Capitalizing upon the Lab-on-a-Valve (LOV) concept, the mesofluidic device integrates on-chip micro-solid phase extraction (μSPE) in automatic disposable mode followed by chemical vapor generation and gas-liquid separation prior to in-line atomic fluorescence spectrometric detection. In contrast to prevailing chelating sorbents for Hg(II), bare poly(divinylbenzene-N-vinylpyrrolidone) copolymer sorptive beads were resorted to efficient uptake of Hg(II) in hydrochloric acid milieu (pH=2.3) without the need for metal derivatization nor pH adjustment of prior acidified water samples for preservation to near-neutral conditions. Experimental variables influencing the sorptive uptake and retrieval of target species and the evolvement of elemental mercury within the miniaturized integrated reaction chamber/gas-liquid separator were investigated in detail. Using merely <10 mg of sorbent, the limits of detection and quantification at the 3s(blank) and 10s(blank) levels, respectively, for a sample volume of 3 mL were 12 and 42 ng L(-1) Hg(II) with a dynamic range extending up to 5.0 μg L(-1). The proposed mesofluidic platform copes with the requirements of regulatory bodies (US-EPA, WHO, EU-Commission) for drinking water quality and surface waters that endorse maximum allowed concentrations of mercury spanning from 0.07 to 6.0 μg L(-1). Demonstrated with the analysis of aqueous samples of varying matrix complexity, the LOV approach afforded reliable results with relative recoveries of 86-107% and intermediate precision down to 9% in the renewable μSPE format. PMID:23618176

  8. INTEGRACIÓN DE TECNOLOGÍAS EN UNA PLATAFORMA J2EE DIRIGIDA POR MODELOS TECHNOLOGIES INTEGRATION IN A MODEL DRIVEN J2EE PLATFORM

    Directory of Open Access Journals (Sweden)

    David Colque C

    2006-12-01

    Full Text Available Este documento presenta una propuesta de cómo integrar adecuadamente diversas tecnologías de persistencia, de negocios y web en una plataforma J2EE. Esto involucra una arquitectura de múltiples capas, que considera para cada capa el uso de soluciones prácticas efectivas en el desarrollo de software, también se considera el uso del paradigma de desarrollo dirigido por modelos (MDA para facilitar su integración, implementado en el Framework Open Source AndroMDA, y el proceso de desarrollo propuesto por Larman. De este modo se pretende fortalecer el desarrollo orientado a objetos al incorporar una herramienta MDA que genera código a partir de los modelos de cada plataforma específica e incentivar el uso de modelos en el proceso de desarrollo del software, mejorando así la calidad del software, la portabilidad, la interoperabilidad y la reusabilidad, como también la independencia de las tecnologías usadas en cada capa.This work presents a proposal for integrating properly diverse technologies of persistence of business and Web in a J2EE platform. This involves an architecture of diverse layers, which considers the use of effective practical solutions for each layer in the development of the software. Also are considered the use of the Model Driven Architecture Paradigm, for facilitating integration performed in the Open Source AndroMDA Framework, and the development process proposed by Larman. This process is aimed at strengthening the development oriented to objects, when incorporating a MDA tool, which generates codes from the models of every specific platform; encouraging the use of models in the process of software development, improving the quality, the portability, the interoperability, as well as reusing the software, and also the self sufficiency of the technologies used in every layer.

  9. OncDRS: An integrative clinical and genomic data platform for enabling translational research and precision medicine

    Directory of Open Access Journals (Sweden)

    John Orechia

    2015-09-01

    Full Text Available We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS and a suite of tools called Oncology Data Retrieval Systems (OncDRS. OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has delivered data for more than 50 research studies.

  10. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing

    DEFF Research Database (Denmark)

    Oprea, Tudor; Nielsen, Sonny Kim; Ursu, Oleg;

    2011-01-01

    benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based...... on 7684 approved drug labels, ADL (Dailymed) via text mining. From the ADL corresponding to 988 unique drugs, the "adverse reactions" section was mapped onto 174 SE, then clustered via principal component analysis into a 5 x 5 self-organizing map that was integrated into a Cytoscape network of SE......Finding new uses for old drugs is a strategy embraced by the pharmaceutical industry, with increasing participation from the academic sector. Drug repurposing efforts focus on identifying novel modes of action, but not in a systematic manner. With intensive data mining and curation, we aim to apply...

  11. Advances in integrated and sustainable supply chain planning concepts, methods, tools and solution approaches toward a platform for industrial practice

    CERN Document Server

    Laínez-Aguirre, José Miguel

    2015-01-01

    Decision making at the enterprise level often encompass not only production operations and  product R&D, but other strategic functions such as financial planning and marketing. With the aim of maximizing growth and a firm’s value, companies often focus on co-ordinating these functional components as well as traditional hierarchical decision levels. Understanding this interplay can enhance enterprise capabilities of adaptation and response to uncertainties arising from internal processes as well as the external environment. This book presents concepts, methods, tools and solutions based on mathematical programming, which provides the quantitative support needed for integrated decision-making and ultimately for improving the allocation of overall corporate resources (e.g., materials, cash and personnel). Through a systems perspective, the integrated planning of the supply chain also promotes activities of reuse, reduction and recycling for achieving more sustainable environmental impacts of production/di...

  12. Process integration and economic analysis of bio-oil platform for the production of methanol and combined heat and power

    International Nuclear Information System (INIS)

    Process to process material and heat integration strategies for bio-oil integrated gasification and methanol synthesis (BOIG-MeOH) systems were developed to assess their technological and economic feasibility. Distributed bio-oil generations and centralised processing enhance resource flexibility and technological feasibility. Economic performance depends on the integration of centralised BOIG-MeOH processes, investigated for cryogenic air separation unit (ASU) and water electrolyser configurations. Design and operating variables of gasification, heat recovery from gases, water and carbon dioxide removal units, water-gas shift and methanol synthesis reactors and CHP network were analysed to improve the overall efficiency and economics. The efficiency of BOIG-MeOH system using bio-oil from various feedstocks was investigated. The system efficiency primarily attributed by the moisture content of the raw material decreases from oilseed rape through miscanthus to poplar wood. Increasing capacity and recycle enhances feasibility, e.g.1350 MW BOIG-MeOH with ASU and 90% recycle configuration achieves an efficiency of 61.5% (methanol, low grade heat and electricity contributions by 89%, 7.9% and 3% respectively) based on poplar wood and the cost of production (COP) of methanol of 318.1 Euro/t for the prices of bio-oil of 75 Euro/t and electricity of 80.12 Euro/MWh, respectively. An additional transportation cost of 4.28-8.89 Euro/t based on 100 km distance between distributed and centralised plants reduces the netback of bio-oil to 40.9-36.3 Euro/t.

  13. Quantification, challenges and outlook of PV integration in the power system: a review by the European PV Technology Platform

    DEFF Research Database (Denmark)

    Alet, Pierre-Jean; Baccaro, Federica; De Felice, Matteo;

    2015-01-01

    Integration in the power system has become a limiting factor to the further development of photovoltaics. Proper quantification is needed to evaluate both issues and solutions; the share of annual electricity demand is widely used but we found that some of the metrics which are related to power...... resilience). Many of the technical solutions to these issues rely on the inverters as actuators (e.g., for control of active and reactive power) or as interfaces (e.g., for local storage). This role requires further technical standardisation and needs to be taken into account in the planning of power...

  14. Integrated physiological, biochemical and molecular analysis identifies important traits and mechanisms associated with differential response of rice genotypes to elevated temperature

    Directory of Open Access Journals (Sweden)

    Boghireddy eSailaja

    2015-11-01

    Full Text Available In changing climate, heat stress caused by high temperature poses a serious threat to rice cultivation. A multiple organizational analysis at physiological, biochemical and molecular level is required to fully understand the impact of elevated temperature in rice. This study was aimed at deciphering the elevated temperature response in eleven popular and mega rice cultivars widely grown in India. Physiological and biochemical traits specifically membrane thermostability (MTS, antioxidants, and photosynthesis were studied at vegetative and reproductive phases which were used to establish a correlation with grain yield under stress. Several useful traits in different genotypes were identified which will be important resource to develop high temperature tolerant rice cultivars. Interestingly, Nagina22 emerged as best performer in terms of yield as well as expression of physiological and biochemical traits at elevated temperature. It showed lesser relative injury, lesser reduction in chlorophyll content, increased super oxide dismutase, catalase and peroxidase activity, lesser reduction in net photosynthetic rate (PN, high transpiration rate (E and other photosynthetic/ fluorescence parameters contributing to least reduction in spikelet fertility and grain yield at elevated temperature. Further, expression of 14 genes including heat shock transcription factors and heat shock proteins was analyzed in Nagina22 (tolerant and Vandana (susceptible at flowering phase, strengthening the fact that N22 performs better at molecular level also during elevated temperature. This study shows that elevated temperature response is complex and involves multiple biological processes which are needed to be characterized to address the challenges of future climate extreme conditions.

  15. Development and Application of Integrated Test Platform for Pure Electric Bus Power System%纯电动客车动力系统集成试验台的研发与应用

    Institute of Scientific and Technical Information of China (English)

    陶银鹏; 张晓玉; 徐贤亚

    2014-01-01

    介绍一种纯电动客车动力系统集成试验台的研发及应用。该试验台采用动力电池包作为动力源,将整车控制策略集成到试验台控制系统中,实现整车控制策略的标定和验证,增加驾驶员实际操作作为系统输入,用于纯电动客车车载动力系统的试验、开发、匹配、标定以及整车控制策略验证。%The authors introduce the development and application of an integrated test platform's for the pure elec-tric bus power system. The test platform uses battery pack as the power supply. The vehicle control strategy is inte-grated into the test platform control system. The calibration and validation of the vehicle's control strategy is also in-tegrated. The platform uses the driver's operation as the system input. So this test platform can be used for test, de-velopment, matching, calibration and validation of vehicle control strategy of the pure electric bus power system.

  16. Integrated TLWP-FPSO (Tension Leg Wellhead Platform-Floating Production, Storage and Offloading Vessel) solution for deep water field development offshore Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Neil; Heidari, Homayoun; Large, Sean [SBM Atlantia, Houston, TX (United States)

    2008-07-01

    A development strategy for some deep water fields offshore Brazil consists of a TLWP (Tension-Leg Wellhead Platform) connected by a fluid transfer line to a nearby FPSO. The TLWP provides dry tree riser support, drilling capability, manifolding, test separation, and multiphase pumping, while all other functions including full processing, accommodations, gas compression, power generation, water and chemical injection, storage and offloading, and gas export are provided by the FPSO. In one such scenario, the TLWP and FPSO could be connected using SBM's GAP mid-water fluid transfer line technology, with SBM Atlantia's FourStar{sup TM} hull concept for the TLWP. The FourStar{sup TM} is designed to be quayside- or float over-integrable, thus eliminating the need for a heavy lift installation vessel; while being structurally and hydrodynamically superior to other TLP alternatives. This paper presents a description of the technical development of the FourStar{sup TM} TLP and an overview of the GAP technology, and discusses the characteristics of an integrated TLWP-GAP-FPSO field development solution for a typical application offshore Brazil (author)

  17. Universal visualization platform

    Science.gov (United States)

    Gee, Alexander G.; Li, Hongli; Yu, Min; Smrtic, Mary Beth; Cvek, Urska; Goodell, Howie; Gupta, Vivek; Lawrence, Christine; Zhou, Jainping; Chiang, Chih-Hung; Grinstein, Georges G.

    2005-03-01

    Although there are a number of visualization systems to choose from when analyzing data, only a few of these allow for the integration of other visualization and analysis techniques. There are even fewer visualization toolkits and frameworks from which one can develop ones own visualization applications. Even within the research community, scientists either use what they can from the available tools or start from scratch to define a program in which they are able to develop new or modified visualization techniques and analysis algorithms. Presented here is a new general-purpose platform for constructing numerous visualization and analysis applications. The focus of this system is the design and experimentation of new techniques, and where the sharing of and integration with other tools becomes second nature. Moreover, this platform supports multiple large data sets, and the recording and visualizing of user sessions. Here we introduce the Universal Visualization Platform (UVP) as a modern data visualization and analysis system.

  18. Lab-on-a-robot: integrated microchip CE, power supply, electrochemical detector, wireless unit, and mobile platform.

    Science.gov (United States)

    Berg, Christopher; Valdez, David C; Bergeron, Phillip; Mora, Maria F; Garcia, Carlos D; Ayon, Arturo

    2008-12-01

    In this paper, the fabrication of a wireless mobile unit containing an electrochemical detection module and a 3-channel high-voltage power supply (HVPS) designed for microchip CE is described. The presented device consists of wireless global positioning system controlled robotics, an electrochemical detector utilizing signal conditioning analog circuitry and a digital feedback range controller, a HVPS, an air pump, and a CE microchip. A graphical user interface (LabVIEW) was also designed to communicate wirelessly with the device, from a distant personal computer communication port. The entire device is integrated and controlled by digital hardware implemented on a field programmable gate array development board. This lab-on-a-robot is able to navigate to a global position location, acquire an air sample, perform the analysis (injection, separation, and detection), and send the data (electropherogram) to a remote station without exposing the analyst to the testing environment. PMID:19130571

  19. Hierarchical DSE for multi-ASIP platforms

    DEFF Research Database (Denmark)

    Micconi, Laura; Corvino, Rosilde; Gangadharan, Deepak; Madsen, Jan; Pop, Paul; Jozwiak, Lech

    This work proposes a hierarchical Design Space Exploration (DSE) for the design of multi-processor platforms targeted to specific applications with strict timing and area constraints. In particular, it considers platforms integrating multiple Application Specific Instruction Set Processors (ASIPs...

  20. ARCHITECTURE OF INTEGRATION CLOUD PLATFORM Архитектура интеграционной облачной платформы

    Directory of Open Access Journals (Sweden)

    Elovikov A. E.

    2013-05-01

    Full Text Available This article presents the elements of the integration cloud platform, the tasks it solves, the components of the platform and the relationships between them. The types of applications of the platform are defined and the interactions between them are described

  1. Payment Platform

    DEFF Research Database (Denmark)

    Hjelholt, Morten; Damsgaard, Jan

    2012-01-01

    Payment transactions through the use of physical coins, bank notes or credit cards have for centuries been the standard formats of exchanging money. Recently online and mobile digital payment platforms has entered the stage as contenders to this position and possibly could penetrate societies...... applies a co-evolutionary multilevel perspective to model the interplay and processes between technology and society wherein digital payment platforms potentially will substitute other payment platforms just like the credit card negated the check. On this basis this paper formulate a multilevel conceptual...

  2. HPC - Platforms Penta Chart

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo, Angelina Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-08

    Strategy, Planning, Acquiring- very large scale computing platforms come and go and planning for immensely scalable machines often precedes actual procurement by 3 years. Procurement can be another year or more. Integration- After Acquisition, machines must be integrated into the computing environments at LANL. Connection to scalable storage via large scale storage networking, assuring correct and secure operations. Management and Utilization – Ongoing operations, maintenance, and trouble shooting of the hardware and systems software at massive scale is required.

  3. Study on Contemporary Management Integrated Platform in Chengdu East Railway Station%成都东客站现代管理集成平台研究

    Institute of Scientific and Technical Information of China (English)

    杨捷

    2012-01-01

    To change status quo that information system is separated with other electromechanical systems in large railway stations, contemporary management integrated platform in Chengdu East Railway Station is quoted as the research exam- ple. Information system and electromechanical systems are brought into unified management by integrating station BAS, FAS, drinking water system, building environment monitoring system, passenger service information system and booking system. Interfaces for connecting other traffic systems like metro, bus, long distance coach and airline are provided so as to realize system integration, data sharing, coordinated manipulation, accomplish the objective of energy - saving, cut- ting payroll to improve efficiency, unified management and chain reaction in emergency.%为改变大型客站旅客服务信息系统与其它机电系统各自独立控制的现状,以成都东客站为例研究设置大型客站现代管理集成平台,集约利用车站相关信息系统和机电设备系统,将车站BAS、FAS、直饮水系统、机房环境监测系统、旅客服务信息系统等纳入平台统一管理,与客票系统互联,并提供与地铁、公交、长途、航空等其它交通信息系统的接口,实现系统融合、数据共享、联合操控,从而达到节能减排、减员增效、统一管理、应急联动的目的。

  4. Plants in silico: why, why now and what?--an integrative platform for plant systems biology research.

    Science.gov (United States)

    Zhu, Xin-Guang; Lynch, Jonathan P; LeBauer, David S; Millar, Andrew J; Stitt, Mark; Long, Stephen P

    2016-05-01

    A paradigm shift is needed and timely in moving plant modelling from largely isolated efforts to a connected community endeavour that can take full advantage of advances in computer science and in mechanistic understanding of plant processes. Plants in silico (Psi) envisions a digital representation of layered dynamic modules, linking from gene networks and metabolic pathways through to cellular organization, tissue, organ and whole plant development, together with resource capture and use efficiency in dynamic competitive environments, ultimately allowing a mechanistically rich simulation of the plant or of a community of plants in silico. The concept is to integrate models or modules from different layers of organization spanning from genome to phenome to ecosystem in a modular framework allowing the use of modules of varying mechanistic detail representing the same biological process. Developments in high-performance computing, functional knowledge of plants, the internet and open-source version controlled software make achieving the concept realistic. Open source will enhance collaboration and move towards testing and consensus on quantitative theoretical frameworks. Importantly, Psi provides a quantitative knowledge framework where the implications of a discovery at one level, for example, single gene function or developmental response, can be examined at the whole plant or even crop and natural ecosystem levels. PMID:26523481

  5. Microalgal-biotechnology as a platform for an integral biogas upgrading and nutrient removal from anaerobic effluents.

    Science.gov (United States)

    Bahr, Melanie; Díaz, Ignacio; Dominguez, Antonio; González Sánchez, Armando; Muñoz, Raul

    2014-01-01

    The potential of a pilot high rate algal pond (HRAP) interconnected via liquid recirculation with an external absorption column for the simultaneous removal of H2S and CO2 from biogas using an alkaliphilic microalgal-bacterial consortium was evaluated. A bubble column was preferred as external absorption unit to a packed bed column based on its ease of operation, despite showing a comparable CO2 mass transfer capacity. When the combined HRAP-bubble column system was operated under continuous mode with mineral salt medium at a biogas residence time of 30 min in the absorption column, the system removed 100% of the H2S (up to 5000 ppmv) and 90% of the CO2 supplied, with O2 concentrations in the upgraded biogas below 0.2%. The use of diluted centrates as a free nutrient source resulted in a gradual decrease in CO2 removal to steady values of 40%, while H2S removal remained at 100%. The anaerobic digestion of the algal-bacterial biomass produced during biogas upgrading resulted in a CH4 yield of 0.21-0.27 L/gVS, which could satisfy up to 60% of the overall energy demand for biogas upgrading. This proof of concept study confirmed that algal-bacterial photobioreactors can support an integral upgrading without biogas contamination, with a net negative CO2 footprint, energy production, and a reduction of the eutrophication potential of the residual anaerobic effluents. PMID:24298934

  6. An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework.

    Science.gov (United States)

    Chen, Yi-An; Tripathi, Lokesh P; Mizuguchi, Kenji

    2016-01-01

    Data analysis is one of the most critical and challenging steps in drug discovery and disease biology. A user-friendly resource to visualize and analyse high-throughput data provides a powerful medium for both experimental and computational biologists to understand vastly different biological data types and obtain a concise, simplified and meaningful output for better knowledge discovery. We have previously developed TargetMine, an integrated data warehouse optimized for target prioritization. Here we describe how upgraded and newly modelled data types in TargetMine can now survey the wider biological and chemical data space, relevant to drug discovery and development. To enhance the scope of TargetMine from target prioritization to broad-based knowledge discovery, we have also developed a new auxiliary toolkit to assist with data analysis and visualization in TargetMine. This toolkit features interactive data analysis tools to query and analyse the biological data compiled within the TargetMine data warehouse. The enhanced system enables users to discover new hypotheses interactively by performing complicated searches with no programming and obtaining the results in an easy to comprehend output format. Database URL: http://targetmine.mizuguchilab.org. PMID:26989145

  7. THE PERIGEO PROJECT: INERTIAL AND IMAGING SENSORS PROCESSING, INTEGRATION AND VALIDATION ON UAV PLATFORMS FOR SPACE NAVIGATION

    Directory of Open Access Journals (Sweden)

    P. Molina

    2014-03-01

    Full Text Available The PERIGEO R&D project aims at developing, testing and validating algorithms and/or methods for space missions in various field of research. This paper focuses in one of the scenarios considered in PERIGEO: navigation for atmospheric flights. Space missions heavily rely on navigation to reach success, and autonomy of on-board navigation systems and sensors is desired to reach new frontiers of space exploration. From the technology side, optical frame cameras, LiDAR and inertial technologies are selected to cover the requirements of such missions. From the processing side, image processing techniques are developed for vision-based relative and absolute navigation, based on point extraction and matching from camera images, and crater detection and matching in camera and LiDAR images. The current paper addresses the challenges of space navigation, presents the current developments and preliminary results, and describes payload elements to be integrated in an Unmanned Aerial Vehicle (UAV for in-flight testing of systems and algorithms. Again, UAVs are key enablers of scientific capabilities, in this case, to bridge the gap between laboratory simulation and expensive, real space missions.

  8. Design of an Integrated Sensor Platform for Vital Sign Monitoring of Newborn Infants at Neonatal Intensive Care Units

    Directory of Open Access Journals (Sweden)

    Wei Chen

    2010-01-01

    Full Text Available Continuous health status monitoring and advances in medical treatments have resulted in a significant increase of survival rate in critically ill infants admitted into Neonatal Intensive Care Units (NICUs. The quality of life and long-term health prospects of the neonates depend increasingly on the reliability and comfort of the monitoring systems. In this paper, we present the design work of a smart jacket for vital sign monitoring of neonates at a NICU. The design represents a unique integration of sensor technology, user focus and design aspects. Textile sensors, a reflectance pulse oximeter and a wearable temperature sensor were proposed to be embedded into the smart jacket. Location of the sensor, materials and appearance were designed to optimize the functionality, patient comfort and the possibilities for aesthetic features. Prototypes were built for demonstrating the design concept and experimental results were obtained from tests on premature babies at the NICU of M�xima Medical Centre (MMC in Veldhoven, the Netherlands.

  9. Ocean thermal energy conversion (OTEC) platform configuration and integration. Final report. Volume I. Systems requirements and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    Studies leading to the development of two 400 MW Offshore Thermal Energy Conversion Commercial Plants are presented. This volume includes a summary of three tasks: task IIA--systems evaluation and requirements; task IIB--evaluation plan; task III--technology review; and task IV--systems integration evaluation. Task IIA includes the definition of top level requirements and an assessment of factors critical to the selection of hull configuration and size, quantification of payload requirements and characteristics, and sensitivity of system characteristics to site selection. Task IIB includes development of a methodology for systematically evaluating the candidate hullforms, based on interrelationships and priorities developed during task IIA. Task III includes the assessment of current technology and identification of deficiencies in relation to OTEC requirements and the development of plans to correct such deficiencies. Task IV involves the formal evaluation of the six candidate hullforms in relation to sit and plant capacity to quantify cost/size/capability relationships, leading to selection of an optimum commercial plant. (WHK)

  10. Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.

    Science.gov (United States)

    Martelli, Claudia; Iavarone, Federica; D'Angelo, Luca; Arba, Morena; Vincenzoni, Federica; Inserra, Ilaria; Delfino, Daniela; Rossetti, Diana Valeria; Caretto, Marta; Massimi, Luca; Tamburrini, Gianpiero; Di Rocco, Concezio; Caldarelli, Massimo; Messana, Irene; Castagnola, Massimo; Sanna, Maria Teresa; Desiderio, Claudia

    2015-06-01

    A top-down/bottom-up integrated proteomic approach based on LC-MS and 2-DE analysis was applied for comparative characterization of medulloblastoma and pilocytic astrocytoma posterior cranial fossa pediatric brain tumor tissues. Although rare, primary brain tumors are the most frequent solid tumors in the pediatric age. Among them the medulloblastoma is the prevalent malignant tumor in childhood while pilocytic astrocytoma is the most common, rarely showing a malignant progression. Due to the limited availability of this kind of sample, the study was applied to pooled tumor tissues for a preliminary investigation. The results showed different proteomic profiles of the two tumors and evidenced interesting differential expression of several proteins and peptides. Top-down proteomics of acid-soluble fractions of brain tumor homogenates ascribed a potential biomarker role of malignancy to β- and α-thymosins and their truncated proteoforms and to C-terminal truncated (des-GG) ubiquitin, resulting exclusively detected or over-expressed in the highly malignant medulloblastoma. The bottom-up proteomics of the acid-soluble fraction identified several proteins, some of them in common with 2-DE analysis of acid-insoluble pellets. Peroxiredoxin-1, peptidyl-prolyl cis-trans isomerase A, triosephosphate isomerase, pyruvate kinase PKM, tubulin beta and alpha chains, heat shock protein HSP-90-beta and different histones characterized the medulloblastoma while the Ig kappa chain C region, serotransferrin, tubulin beta 2A chain and vimentin the pilocytic astrocytoma. The two proteomic strategies, with their pros and cons, well complemented each other in characterizing the proteome of brain tumor tissues and in disclosing potential disease biomarkers to be validated in a future study on individual samples of both tumor histotypes. PMID:25909245

  11. Design of Integrated Software Platform for Log Data Processing and Interpretation%测井处理解释一体化软件平台的设计

    Institute of Scientific and Technical Information of China (English)

    李长文; 余春昊; 周军; 李国军; 刘复屏

    2011-01-01

    According to the requirement of multi-subject integration reservoir evaluation, discussed are some key technologies of software platform for log data processing and interpretation, such as the software architecture, database system, integrated application framework and visualized interaction. These technologies are helpful to data sharing and application integration. The log database system includes document database (log database, core database and interpreting knowledge database) and project database directly used in log interpretation and reservoir evaluation. The interpreting knowledge database can store reservoir characteristics, relations of the characteristics, log interpretation models, oil/gas identification charts, typical curve patterns, etc Proposed is a log data management method for multi-data sources, which can be applied to network data log and stand-alone file systems, so, providing an approved platform for data sharing and coordinated job. Using the integrated application framework and visualized user interface, log interpretation can be carried out easily and interactively, thus, meeting the requirement of multi-level user complex formation in integrated evaluation.%根据油气藏多学科综合评价需要,从数据共享、应用集成等方面探讨了测井处理解释一体化软件的总体架构、数据库系统、集成应用框架及交互可视化等关键技术.测井解释数据库系统包括由测井资料库、数字岩心库、解释知识库等构成的归档数据库和直接用于测井油气层评价的工区项目数据库2个部分,其中解释知识库能够分区块分层系存储储层特征、“四性”关系、解释模型、识别标准、典型图例等资料.提出了一套适应多数据源的测井数据管理解决方案,能够兼顾网络数据库与单机文件系统,为数据共享与协同工作提供良好的工作平台.通过集成化应用框架与可视化用户界面的设计与开发,实现了测

  12. 基于SOA架构的农村信息资源集成平台设计%Design of Rural Information Resource Integration Platform Based on SOA

    Institute of Scientific and Technical Information of China (English)

    段延娥

    2012-01-01

    The rural informatization refers to the widespread application and promotion of communication technology and computer technology in rural production, life and social management, and is a very important part of social informatization. The information resource construction as the core content of rural informatization construction, has the direct impact on the level of rural informatization construction. On the basis of sufficient analyzing the current situation of our country rural information resources construction, the existing problems of the rural information resources construction were discussed in detail, and the concept, basic theory and implementation technique of service-oriented architecture (SOA) aredescribed. Using the designing theory of SOA, a comprehensive information resource integration platform based on SOA was presented, and the basic principle and model of design, and SSO design of the integration platform was discussed in details.%农村信息化是指通讯技术和计算机技术在农村生产、生活和社会管理中实现普遍应用和推广的过程,是社会信息化的重要组成部分。农村信息资源建设作为农村信息化建设的核心内容,直接影响着农村信息化建设的水平。在充分分析我国农村信息资源建设现状和发展瓶颈的基础上,详细探讨了农村信息资源建设中存在的问题,阐述了面向服务的体系架构SOA的基本内涵、工作原理、实现技术。利用面向服务架构的设计思想,提出了基于SOA架构的农村信息资源集成平台建设,重点讨论了集成平台的设计原则、设计模型及SSO安全性设计。

  13. 医疗数据集成平台的研究与设计%Research and Design of Medical Data Integration Platform

    Institute of Scientific and Technical Information of China (English)

    胡芳; 沈绍武

    2015-01-01

    目的:本文通过深入分析医院信息系统建设的特点和医疗数据集成的需求,结合医疗数据的异构多源、庞大复杂、动态增长等特点,旨在解决医院各个系统之间的信息互通,实现医院内部系统之间的数据共享.方法:该集成平台以XML技术为基础,采用XML Schema技术来描述集成平台的公共数据模型;利用统一查询语言XQuery进行全局和局部医疗数据查询.结果:提出了一种以HL7标准为基础的基于中间件技术的医疗数据集成平台架构.结论:该平台利用中间件屏蔽底层医疗数据的异构性,最终实现用户对全院医疗数据的全局查询和透明访问.%In this paper, through in-depth study on characteristics of hospital information system (HIS) construction and requirements of medical data integration, and combined with the medical data straits of heterogeneity, multi-source, complexity, dynamic growth, etc., the problem of information exchange in different systems was aimed to solved, in order to realize medical data sharing among internal systems in hospital.Based on Extensible Markup Language (XML), public data model was described by XML Schema technology. Global and local medical data were queried using XQuery technology. The results showed that a medical data integration platform based on HL7 standard and the middleware technologies were proposed. It was concluded that the platform shielded the heterogeneity of underlying medical data by middleware technology. It finally realized the global query and transparent access of medical data in HIS for users.

  14. A novel sensing platform based on ionic liquid integrated carboxylic-functionalized graphene oxide nanosheets for honokiol determination

    International Nuclear Information System (INIS)

    Highlights: • Piperidinium based ionic liquid bearing pyrrole was synthesized. • Ionic liquid integrated graphene oxide nanocompisite was fabricated. • Polymerized ionic liquid-graphene oxide film electrode was prepared. • The film electrode exhibits high sensitivity towards honokiol and magnolol. • Stimulate determination of honokiol and magnolol was fulfilled. - Abstract: A novel ionic liquid, 4-hydroxy-1-methyl-[1-(3-pyrrolyl-propyl)]-piperidinium bromide, was synthesized and characterized. Carboxylic-functionalized graphene oxide nanosheets were modified with this ionic liquid to fabricate a nanocomposite which was denoted as GrO-COO-IL. Characterizations of FTIR, X-ray photoelectron spectroscopy, Raman spectroscopy and transmission electron microscopy confirmed the successful conjunction of these two components. GrO-COO-IL nanocomposites were homogeneously dispersed with utralpure water, and were then coated onto glassy carbon electrode surface. Followed by cyclic voltammetric scanning, a graphene oxide-polymerized ionic liquid film modified electrode (GrO-COO-Poly-IL/GCE) was prepared, and was studied with electrochemical impedance spectroscopy and scanning electron microscope. It was found that both honokiol and magnolol exhibit sensitive voltammetric response at the GrO-COO-Poly-IL/GCE. Simultaneous assay of honokiol and magnolol was realized with differential pulse voltametry. In the presence of magnolol, the oxidation peak current was linearly related to honokiol concentration in the range of 1.0 × 10−8 ∼ 1.0 × 10−5 mol L−1 with a detection limit of 1.53 × 10−9 mol L−1 (S/N = 3). Meanwhile, in the presence of honokiol, a linear relationship between the oxidation peak current and magnolol concentration was found from 7.0 × 10−8 to 1.0 × 10−5 mol L−1. The detection limit is calculated to be 8.27 × 10 −9 mol L−1 (S/N = 3). In addition, GrO-COO-Poly-IL/GCE was successfully used for determination of honokiol in the

  15. The Real Time Mission Monitor: A Platform for Real Time Environmental Data Integration and Display during NASA Field Campaigns

    Science.gov (United States)

    He, M.; Hardin, D. M.; Goodman, M.; Blakeslee, R.

    2008-05-01

    The Real Time Mission Monitor (RTMM) is an interactive visualization application based on Google Earth, that provides situational awareness and field asset management during NASA field campaigns. The RTMM can integrate data and imagery from numerous sources including GOES-12, GOES-10, and TRMM satellites. Simultaneously, it can display data and imagery from surface observations including Nexrad, NPOL and SMART- R radars. In addition to all these it can display output from models and real-time flight tracks of all aircraft involved in the experiment. In some instances the RTMM can also display measurements from scientific instruments as they are being flown. All data are recorded and archived in an on-line system enabling playback and review of all sorties. This is invaluable in preparing for future deployments and in exercising case studies. The RTMM facilitates pre-flight planning, in-flight monitoring, development of adaptive flight strategies and post- flight data analyses and assessments. Since the RTMM is available via the internet - during the actual experiment - project managers, scientists and mission planners can collaborate no matter where they are located as long as they have a viable internet connection. In addition, the system is open so that the general public can also view the experiment, in-progress, with Google Earth. Predecessors of RTMM were originally deployed in 2002 as part of the Altus Cumulus Electrification Study (ACES) to monitor uninhabited aerial vehicles near thunderstorms. In 2005 an interactive Java-based web prototype supported the airborne Lightning Instrument Package (LIP) during the Tropical Cloud Systems and Processes (TCSP) experiment. In 2006 the technology was adapted to the 3D Google Earth virtual globe and in 2007 its capabilities were extended to support multiple NASA aircraft (ER-2, WB-57, DC-8) during Tropical Composition, Clouds and Climate Coupling (TC4) experiment and 2007 Summer Aerosonde field study. In April 2008

  16. Environmental data for the planning of off-shore wind parks from the EnerGEO Platform of Integrated Assessment (PIA)

    International Nuclear Information System (INIS)

    The EU-sponsored EnerGEO project aims at providing decision makers with a modelling platform to assess the environmental impacts of different sources of renewable energy. One of the pillars of the project is the Wind Energy Pilot, addressing the effects of offshore wind parks on air pollution and energy use. The methods used in the pilot and the underlying environmental databases are integrated into a WebGIS client tool and made available to the public. This paper is dedicated to describing the environmental databases and supporting data incorporated in the client tool. A 27-km resolution, 11-year wind database is created using the WRF model. The wind database is used to assess the wind climate in the north-west Atlantic region and to derive the potential power output from offshore wind parks. Auxiliary data concerning water depth, distance to shore and distance to the nearest suitable port are created to aid the planning and maintenance phases. Seasonal workability conditions are assessed using a 20-year wave database. The distance at which future wind parks should be placed to exhibit different wind climates is investigated. (orig.)

  17. Linking human health and livestock health: a "one-health" platform for integrated analysis of human health, livestock health, and economic welfare in livestock dependent communities.

    Directory of Open Access Journals (Sweden)

    S M Thumbi

    Full Text Available For most rural households in sub-Saharan Africa, healthy livestock play a key role in averting the burden associated with zoonotic diseases, and in meeting household nutritional and socio-economic needs. However, there is limited understanding of the complex nutritional, socio-economic, and zoonotic pathways that link livestock health to human health and welfare. Here we describe a platform for integrated human health, animal health and economic welfare analysis designed to address this challenge. We provide baseline epidemiological data on disease syndromes in humans and the animals they keep, and provide examples of relationships between human health, animal health and household socio-economic status.We designed a study to obtain syndromic disease data in animals along with economic and behavioral information for 1500 rural households in Western Kenya already participating in a human syndromic disease surveillance study. Data collection started in February 2013, and each household is visited bi-weekly and data on four human syndromes (fever, jaundice, diarrhea and respiratory illness and nine animal syndromes (death, respiratory, reproductive, musculoskeletal, nervous, urogenital, digestive, udder disorders, and skin disorders in cattle, sheep, goats and chickens are collected. Additionally, data from a comprehensive socio-economic survey is collected every 3 months in each of the study households.Data from the first year of study showed 93% of the households owned at least one form of livestock (55%, 19%, 41% and 88% own cattle, sheep, goats and chickens respectively. Digestive disorders, mainly diarrhea episodes, were the most common syndromes observed in cattle, goats and sheep, accounting for 56% of all livestock syndromes, followed by respiratory illnesses (18%. In humans, respiratory illnesses accounted for 54% of all illnesses reported, followed by acute febrile illnesses (40% and diarrhea illnesses (5%. While controlling for household

  18. Multiscale Observational Platforms and Bayesian Data Integration to Estimate Snow Depth and Snow-water-equivalent over the Ice-wedge Polygonal Tundra

    Science.gov (United States)

    Wainwright, H. M.; Liljedahl, A. K.; Peterson, J.; Dafflon, B.; Ulrich, C.; Gusmeroli, A.; Hubbard, S. S.

    2015-12-01

    Snow has a profound impact on permafrost and ecosystem functioning in the Arctic tundra. Characterizing snow depths and snow-water-equivalent (SWE) is difficult over a large area, since they are quite heterogeneous, particularly in ice-wedge polygonal ground. In this study, we explore various strategies to characterize snow depths and SWE, using multiscale observational platforms, including a snow probe, ground penetrating radar (GPR), unmanned aerial system (UAS) and ground/airborne LiDAR. In addition, our statistical analysis and data locations are designed such that we can characterize the snow heterogeneity in multiple spatial scales. We demonstrate our approach using the datasets collected in the ice-wedge polygonal tundra near Barrow, AK. We first document the characteristics of each platform. GPR can cover ~100s meters, and also provide depth-averaged snow density. The UAS-based snow-surface elevation is used to estimate the snow depth over a larger area with much less labor than GPR. Snow density analysis, using both cores and GPR, suggests that the depth-averaged snow density is quite uniform over the site. The spatial variability of snow depths is then quantified, and correlated with various topographic measures (e.g., curvature) from the LiDAR digital elevation map as well as the wind direction. We explore different scales of moving average to separate micro and macro-topography. Results show that the wind factor is not significant in our case, except for at the edge of a drained thaw-lake basin. The wind distribution fills microtopographic lows (i.e., troughs and centers of low-centered polygons) and creates a smooth snow surface following the macro-topography, which depends on polygon sizes. Finally, we develop a Bayesian geostatistical method to integrate these multiscale datasets for estimating snow depths and SWE over the study site (~1km by 1km). We compare two strategies: interpolating (1) the residual of the topographic correlations or (2) the

  19. GITEWS, an extensible and open integration platform for manifold sensor systems and processing components based on Sensor Web Enablement and the principles of Service Oriented Architectures

    Science.gov (United States)

    Haener, Rainer; Waechter, Joachim; Fleischer, Jens; Herrnkind, Stefan; Schwarting, Herrmann

    2010-05-01

    The German Indonesian Tsunami Early Warning System (GITEWS) is a multifaceted system consisting of various sensor types like seismometers, sea level sensors or GPS stations, and processing components, all with their own system behavior and proprietary data structure. To operate a warning chain, beginning from measurements scaling up to warning products, all components have to interact in a correct way, both syntactically and semantically. Designing the system great emphasis was laid on conformity to the Sensor Web Enablement (SWE) specification by the Open Geospatial Consortium (OGC). The technical infrastructure, the so called Tsunami Service Bus (TSB) follows the blueprint of Service Oriented Architectures (SOA). The TSB is an integration concept (SWE) where functionality (observe, task, notify, alert, and process) is grouped around business processes (Monitoring, Decision Support, Sensor Management) and packaged as interoperable services (SAS, SOS, SPS, WNS). The benefits of using a flexible architecture together with SWE lead to an open integration platform: • accessing and controlling heterogeneous sensors in a uniform way (Functional Integration) • assigns functionality to distinct services (Separation of Concerns) • allows resilient relationship between systems (Loose Coupling) • integrates services so that they can be accessed from everywhere (Location Transparency) • enables infrastructures which integrate heterogeneous applications (Encapsulation) • allows combination of services (Orchestration) and data exchange within business processes Warning systems will evolve over time: New sensor types might be added, old sensors will be replaced and processing components will be improved. From a collection of few basic services it shall be possible to compose more complex functionality essential for specific warning systems. Given these requirements a flexible infrastructure is a prerequisite for sustainable systems and their architecture must be

  20. Standardized design and implementation of integrated information platform for power dispatch%电力调度综合数据平台的标准化设计与实现

    Institute of Scientific and Technical Information of China (English)

    马强; 荆铭; 延峰; 韩少晓; 管荑

    2011-01-01

    An integrated information platform for power dispatch is established. Its hardware system structure is divided into two parts:internal platform and external platform,while its software system structure into five layers:basic platform,data integration,data management,access interface and application. According to the requirement of dispatch application system for the information description, the standard CIM (Common Information Model) is expanded to form a unified public information model for different businesses of dispatch center. The object coding rules based on the path of information model is proposed,and the CIS(Component Interface Specification) is combined with the data extraction and conversion to integrate the dispatch business data into the integrated information platform. The Construction of integrated information platform realizes the organic combination of different application systems in power dispatch center and the high efficiency of data integration and sharing.%构建了一种新型电力调度综合数据平台.综合数据平台系统从硬件体系结构上分为内平台和外平台两部分;从软件体系结构上分为基础平台层、数据整合层、数据管理层、访问接口层和应用层5个层次.结合调度应用系统的信息描述需求,对标准公共信息模型进行了扩展,形成适合调度中心各类业务的统一公共信息模型,提出了一种基于信息模型路径的对象编码规则,并采用了组件接口规范与数据提取、转换相结合的方法,将调度业务系统数据接入综合数据平台.综合数据平台的建设实现了电力调度中心不同应用系统的有机结合,达到了数据的高度整合和共享.

  1. Platform computing

    CERN Multimedia

    2002-01-01

    "Platform Computing releases first grid-enabled workload management solution for IBM eServer Intel and UNIX high performance computing clusters. This Out-of-the-box solution maximizes the performance and capability of applications on IBM HPC clusters" (1/2 page) .

  2. Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus.

    Science.gov (United States)

    Parmeciano Di Noto, Gisela; Jara, Eugenio; Iriarte, Andrés; Centrón, Daniela; Quiroga, Cecilia

    2016-08-01

    Shewanella spp. are currently considered to be emerging pathogens that can code for a blaOXA carbapenemase in their chromosome. Complete genome analysis of the clinical isolate Shewanella sp. Sh95 revealed that this strain is a novel species, which shares a lineage with marine isolates. Characterization of its resistome showed that it codes for genes drfA15, qacH and blaOXA-48. We propose that Shewanella sp. Sh95 acts as reservoir of blaOXA-48. Moreover, analysis of mobilome showed that it contains a novel integrative and conjugative element (ICE), named ICESh95. Comparative analysis between the close relatives ICESpuPO1 from Shewanella sp. W3-18-1 and ICE SXTMO10 from Vibrio cholerae showed that ICESh95 encompassed two new regions, a type III restriction modification system and a multidrug resistance integron. The integron platform contained a novel arrangement formed by gene cassettes drfA15 and qacH, and a class C-attC group II intron. Furthermore, insertion of ICESh95 occurred at a unique target site, which correlated with the presence of a different xis/int module. Mobility of ICESh95 was assessed and demonstrated its ability to self-transfer with high efficiency to different species of bacteria. Our results show that ICESh95 is a self-transmissible, mobile element, which can contribute to the dissemination of antimicrobial resistance; this is clearly a threat when natural bacteria from water ecosystems, such as Shewanella, act as vectors in its propagation. PMID:27215217

  3. A 9 MHz-2.4 GHz Fully Integrated Transceiver IC for a Microfluidic-CMOS Platform Dedicated to Miniaturized Dielectric Spectroscopy.

    Science.gov (United States)

    Bakhshiani, Mehran; Suster, Michael A; Mohseni, Pedram

    2015-12-01

    This paper presents a fully integrated transceiver IC as part of a self-sustained, microfluidic-CMOS platform for miniaturized dielectric spectroscopy (DS) from MHz to GHz. Fabricated in AMS 0.35 μm 2P/4M RF CMOS, the transmitter (TX) part of the IC generates a single-tone sinusoidal signal with frequency tunability in the range of ~ 9 MHz-2.4 GHz to excite a three-dimensional (3D), parallel-plate, capacitive sensor with a floating electrode and 9 μL microfluidic channel for sample delivery. With a material-under-test (MUT) loaded into the sensor, the receiver (RX) part of the IC employs broadband frequency response analysis (bFRA) methodology to measure the amplitude and phase of the RF excitation signal after transmission through the sensor. A one-time, 6-point sensor calibration algorithm then extracts both the real and imaginary parts of the MUT complex permittivity, ϵr, from IC measurements of the sensor transmission characteristics in the voltage domain. The "sensor + IC" is fully capable of differentiating among de-ionized (DI) water, phosphate-buffered saline (PBS), and alcoholic beverages in tests conducted at four excitation frequencies of ∼ 50 MHz , 500 MHz, 1.5 GHz, and 2.4 GHz generated by the TX. Moreover, permittivity readings of PBS by the sensor interfaced with the IC at six excitation frequencies in the range of ~ 50 MHz-2.4 GHz are in excellent agreement (rms error of 1.7% (real) and 7.2% (imaginary)) with those from bulk-solution reference measurements by commercial benchtop equipment. The total power consumption of the IC is with 1.5 V (analog) and 3.3 V (digital) supplies. PMID:26761883

  4. IIS--Integrated Interactome System: a web-based platform for the annotation, analysis and visualization of protein-metabolite-gene-drug interactions by integrating a variety of data sources and tools.

    Directory of Open Access Journals (Sweden)

    Marcelo Falsarella Carazzolle

    Full Text Available High-throughput screening of physical, genetic and chemical-genetic interactions brings important perspectives in the Systems Biology field, as the analysis of these interactions provides new insights into protein/gene function, cellular metabolic variations and the validation of therapeutic targets and drug design. However, such analysis depends on a pipeline connecting different tools that can automatically integrate data from diverse sources and result in a more comprehensive dataset that can be properly interpreted.We describe here the Integrated Interactome System (IIS, an integrative platform with a web-based interface for the annotation, analysis and visualization of the interaction profiles of proteins/genes, metabolites and drugs of interest. IIS works in four connected modules: (i Submission module, which receives raw data derived from Sanger sequencing (e.g. two-hybrid system; (ii Search module, which enables the user to search for the processed reads to be assembled into contigs/singlets, or for lists of proteins/genes, metabolites and drugs of interest, and add them to the project; (iii Annotation module, which assigns annotations from several databases for the contigs/singlets or lists of proteins/genes, generating tables with automatic annotation that can be manually curated; and (iv Interactome module, which maps the contigs/singlets or the uploaded lists to entries in our integrated database, building networks that gather novel identified interactions, protein and metabolite expression/concentration levels, subcellular localization and computed topological metrics, GO biological processes and KEGG pathways enrichment. This module generates a XGMML file that can be imported into Cytoscape or be visualized directly on the web.We have developed IIS by the integration of diverse databases following the need of appropriate tools for a systematic analysis of physical, genetic and chemical-genetic interactions. IIS was validated with

  5. ITS Platform

    DEFF Research Database (Denmark)

    Tøfting, Svend; Lahrmann, Harry; Agerholm, Niels;

    2014-01-01

    Aalborg University and two local companies have over the past four years developed and tested an ITS Platform, which can be used for communication with cars and for providing a number of services to the drivers. The purpose has been to perform a technological test of the possible use of a hidden...... GPS box with data connection to a backend server. The ITS Platform project has had a budget of DKK 33 million (app € 4.4) and it has demonstrated that boxes which register the position of the cars can be helpful to drivers in many ways. Establishing dynamic traffic information and support systems for...... safer and more economic driving is technologically possible. Big Data from the system can provide traffic authorities with a better basis for decision for their traffic planning. Last, but not least, it is possible to establish payment systems. The project has also shown that the boxes in the cars do...

  6. Closing the treatment gap for mental, neurological and substance use disorders by strengthening existing health care platforms: strategies for delivery and integration of evidence-based interventions

    OpenAIRE

    Shidhaye, Rahul; Lund, Crick; Chisholm, Dan

    2015-01-01

    This paper outlines the main elements and features of a mental health care delivery platform and its delivery channels. These include evidence-based interventions that can be delivered via this platform as well as broader health system strengthening strategies for more effective and efficient delivery of services. The focus is broadly on health systems perspective rather than strictly disorder-oriented intervention analysis. A set of evidence-based interventions within the WHO pyramid framewo...

  7. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  8. Recent abstracts in biochemical technology

    OpenAIRE

    R R Siva Kiran; Brijesh P

    2008-01-01

    “Recent abstracts in biochemical technology” is a collection of interesting research articles published in “List of biochemical technology journals” (Table 1). The abstracts are most likely to report significant results in biochemical technology.

  9. Integrating ASCAT surface soil moisture and GEOV1 leaf area index into the SURFEX modelling platform: a land data assimilation application over France

    Science.gov (United States)

    Barbu, A. L.; Calvet, J.-C.; Mahfouf, J.-F.; Lafont, S.

    2014-01-01

    The land monitoring service of the European Copernicus programme has developed a set of satellite-based biogeophysical products, including surface soil moisture (SSM) and leaf area index (LAI). This study investigates the impact of joint assimilation of remotely sensed SSM derived from Advanced Scatterometer (ASCAT) backscatter data and the Copernicus Global Land GEOV1 satellite-based LAI product into the the vegetation growth version of the Interactions between Soil Biosphere Atmosphere (ISBA-A-gs) land surface model within the the externalised surface model (SURFEX) modelling platform of Météo-France. The ASCAT data were bias corrected with respect to the model climatology by using a seasonal-based CDF (Cumulative Distribution Function) matching technique. A multivariate multi-scale land data assimilation system (LDAS) based on the extended Kalman Filter (EKF) is used for monitoring the soil moisture, terrestrial vegetation, surface carbon and energy fluxes across the domain of France at a spatial resolution of 8 km. Each model grid box is divided into a number of land covers, each having its own set of prognostic variables. The filter algorithm is designed to provide a distinct analysis for each land cover while using one observation per grid box. The updated values are aggregated by computing a weighted average. In this study, it is demonstrated that the assimilation scheme works effectively within the ISBA-A-gs model over a four-year period (2008-2011). The EKF is able to extract useful information from the data signal at the grid scale and distribute the root-zone soil moisture and LAI increments throughout the mosaic structure of the model. The impact of the assimilation on the vegetation phenology and on the water and carbon fluxes varies from one season to another. The spring drought of 2011 is an interesting case study of the potential of the assimilation to improve drought monitoring. A comparison between simulated and in situ soil moisture gathered at

  10. Integrating ASCAT surface soil moisture and GEOV1 leaf area index into the SURFEX modelling platform: a land data assimilation application over France

    Directory of Open Access Journals (Sweden)

    A. L. Barbu

    2014-01-01

    Full Text Available The land monitoring service of the European Copernicus programme has developed a set of satellite-based biogeophysical products, including surface soil moisture (SSM and leaf area index (LAI. This study investigates the impact of joint assimilation of remotely sensed SSM derived from Advanced Scatterometer (ASCAT backscatter data and the Copernicus Global Land GEOV1 satellite-based LAI product into the the vegetation growth version of the Interactions between Soil Biosphere Atmosphere (ISBA-A-gs land surface model within the the externalised surface model (SURFEX modelling platform of Météo-France. The ASCAT data were bias corrected with respect to the model climatology by using a seasonal-based CDF (Cumulative Distribution Function matching technique. A multivariate multi-scale land data assimilation system (LDAS based on the extended Kalman Filter (EKF is used for monitoring the soil moisture, terrestrial vegetation, surface carbon and energy fluxes across the domain of France at a spatial resolution of 8 km. Each model grid box is divided into a number of land covers, each having its own set of prognostic variables. The filter algorithm is designed to provide a distinct analysis for each land cover while using one observation per grid box. The updated values are aggregated by computing a weighted average. In this study, it is demonstrated that the assimilation scheme works effectively within the ISBA-A-gs model over a four-year period (2008–2011. The EKF is able to extract useful information from the data signal at the grid scale and distribute the root-zone soil moisture and LAI increments throughout the mosaic structure of the model. The impact of the assimilation on the vegetation phenology and on the water and carbon fluxes varies from one season to another. The spring drought of 2011 is an interesting case study of the potential of the assimilation to improve drought monitoring. A comparison between simulated and in situ soil

  11. Translation of neurological biomarkers to clinically relevant platforms.

    Science.gov (United States)

    Hayes, Ronald L; Robinson, Gillian; Muller, Uwe; Wang, Kevin K W

    2009-01-01

    Like proteomics more generally, neuroproteomics has recently been linked to the discovery of biochemical markers of central nervous system (CNS) injury and disease. Although neuroproteomics has enjoyed considerable success in discovery of candidate biomarkers, there are a number of challenges facing investigators interested in developing clinically useful platforms to assess biomarkers for damage to the CNS. These challenges include intrinsic physiological complications such as the blood-brain barrier. Effective translation of biomarkers to clinical practice also requires development of entirely novel pathways and product development strategies. Drawing from lessons learned from applications of biomarkers to traumatic brain injury, this study outlines major elements of such a pathway. As with other indications, biomarkers can have three major areas of application: (1) drug development; (2) diagnosis and prognosis; (3) patient management. Translation of CNS biomarkers to practical clinical platforms raises a number of integrated elements. Biomarker discovery and initial selection needs to be integrated at the earliest stages with components that will allow systematic prioritization and triage of biomarker candidates. A number of important criteria need to be considered in selecting clinical biomarker candidates. Development of proof of concept assays and their optimization and validation represent an often overlooked feature of biomarker translational research. Initial assay optimization should confirm that assays can detect biomarkers in relevant clinical samples. Since access to human clinical samples is critical to identification of biomarkers relevant to injury and disease as well as for assay development, design of human clinical validation studies is an important component of translational biomarker research platforms. Although these clinical studies share much in common with clinical trials for assessment of drug therapeutic efficacy, there are a number of

  12. Platform christened

    International Nuclear Information System (INIS)

    On Friday May 9, 1997, a ceremony took place in which the Hibernia platform was officially christened by Aline Chretien, the wife of the Prime Minister of Canada. The ceremony highlighted the successful completion of Hibernia and the tremendous accomplishment of this offshore structure which will be towed out of Bull Arm, Newfoundland, in June 1997 to its offshore location. Drilling for the first well will begin in August with first oil expected by December 1997. Other guests at the ceremony included Hibernia owner companies Mobil Oil, Chevron, Petro-Canada, Canada Hibernia Holding Corp., Murphy Oil and Norsk Hydro. The Hibernia project paves the way for other offshore ventures and employment opportunities in Newfoundland

  13. Temperature profiles from expendable bathythermograph (XBT) casts from the BJARNI SAEMUNDSSON and Other Platforms in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) project from 02 February 1974 to 05 April 1974 (NODC Accession 7400351)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the BJARNI SAEMUNDSSON and Other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project. Data were...

  14. Temperature and salinity profiles from CTD casts from the VALERIAN URYVAYEK and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 November 1990 to 31 December 1990 (NODC Accession 9100006)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VALERIAN URYVAYEK and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  15. Temperature and salinity profiles from expendable bathythermograph (XBT) and CTD casts from the NOAA Ship MILLER FREEMAN and other Platforms from Coastal Waters of Washington/Oregon and other locations in support of the Integrated Global Ocean Services System (IGOSS) from 12 July 1977 to 26 July 1983 (NODC Accession 8300102)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT and CTD data were collected from the NOAA Ship MILLER FREEMAN and other Platforms in support of the Integrated Global Ocean Services System (IGOSS) project....

  16. Temperature profiles from expendable bathythermograph (XBT) casts from the ANTON DOHRN II and Other Platforms in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 30 July 1976 to 23 May 1978 (NODC Accession 7800533)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the ANTON DOHRN II and Other Platforms in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by the...

  17. Temperature and salinity profiles from CTD casts from the NOAA Ship MILLER FREEMAN and other PLATFORMS from a World-Wide Distribution in support of the Integrated Global Ocean Services System (IGOSS) from 01 July 1991 to 31 July 1991 (NODC Accession 9100146)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the NOAA Ship MILLER FREEMAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were...

  18. Temperature and salinity profiles from CTD casts from the VOLNA and other PLATFORMS from the North/South Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 February 1989 to 27 February 1989 (NODC Accession 8900053)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the VOLNA and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  19. Temperature and salinity profiles from CTD casts from the OKEAN and other PLATFORMS from the North/South Atlantic Ocean and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 October 1989 to 31 October 1989 (NODC Accession 8900296)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the OKEAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  20. Temperature and salinity profiles from CTD casts from the OKEAN and other PLATFORMS from the North Pacific Ocean, North Atlantic Ocean, and other sea areas in support of the Integrated Global Ocean Services System (IGOSS) from 01 May 1988 to 31 May 1988 (NODC Accession 8800164)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from the OKEAN and other PLATFORMS in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by US...

  1. Integrated assessment of biochemical markers in premetamorphic tadpoles of three amphibian species exposed to glyphosate- and methidathion-based pesticides in single and combination forms.

    Science.gov (United States)

    Güngördü, Abbas; Uçkun, Miraç; Yoloğlu, Ertan

    2016-02-01

    In this study, we evaluated the toxic effects of a glyphosate-based herbicide (GBH) and a methidathion-based insecticide (MBI), individually and in combination, on premetamorphic tadpoles of three anuran species: Pelophylax ridibundus, Xenopus laevis, and Bufotes viridis. Based on the determined 96-h LC50 values of each species, the effects of a series of sublethal concentrations of single pesticides and their mixtures after 96-h exposure and also the time-related effects of a high sublethal concentration of each pesticide were evaluated, with determination of changes in selected biomarkers: glutathione S-transferase (GST), glutathione reductase (GR), acetylcholinesterase (AChE), carboxylesterase (CaE), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Also, the integrated biomarker response (IBR) was used to assess biomarker responses and quantitatively evaluate toxicological effects. Isozyme differences in CaE inhibition were assessed using native page electrophoresis; results showed that GBH to cause structural changes in the enzyme but not CaE inhibition in P. ridibundus. In general, single MBI and pesticide mixture exposures increased GST activity, while single GBH exposures decreased GST activity in exposed tadpoles. The AChE and CaE activities were inhibited after exposure to all single MBI and pesticide mixtures. Also, higher IBR values and GST, GR, AST, and LDH activities were determined for pesticide mixtures compared with single-pesticide exposure. This situation may be indicative of a synergistic interaction between pesticides and a sign of a more stressful condition. PMID:26595308

  2. Process-Based Cost Modeling of Photonics Manufacture: The Cost Competitiveness of Monolithic Integration of a 1550-nm DFB Laser and an Electroabsorptive Modulator on an InP Platform

    Science.gov (United States)

    Fuchs, Erica R. H.; Bruce, E. J.; Ram, R. J.; Kirchain, Randolph E.

    2006-08-01

    The monolithic integration of components holds promise to increase network functionality and reduce packaging expense. Integration also drives down yield due to manufacturing complexity and the compounding of failures across devices. Consensus is lacking on the economically preferred extent of integration. Previous studies on the cost feasibility of integration have used high-level estimation methods. This study instead focuses on accurate-to-industry detail, basing a process-based cost model of device manufacture on data collected from 20 firms across the optoelectronics supply chain. The model presented allows for the definition of process organization, including testing, as well as processing conditions, operational characteristics, and level of automation at each step. This study focuses on the cost implications of integration of a 1550-nm DFB laser with an electroabsorptive modulator on an InP platform. Results show the monolithically integrated design to be more cost competitive over discrete component options regardless of production scale. Dominant cost drivers are packaging, testing, and assembly. Leveraging the technical detail underlying model projections, component alignment, bonding, and metal-organic chemical vapor deposition (MOCVD) are identified as processes where technical improvements are most critical to lowering costs. Such results should encourage exploration of the cost advantages of further integration and focus cost-driven technology development.

  3. Pretreatment Engineering Platform (PEP) Integrated Test B Run Report--Caustic and Oxidative Leaching in UFP-VSL-T02A

    Energy Technology Data Exchange (ETDEWEB)

    Geeting, John GH; Bredt, Ofelia P.; Burns, Carolyn A.; Golovich, Elizabeth C.; Guzman-Leong, Consuelo E.; Josephson, Gary B.; Kurath, Dean E.; Sevigny, Gary J.; Aaberg, Rosanne L.

    2009-12-10

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed and operated as part of a plan to respond to issue M12, “Undemonstrated Leaching Processes” of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. The PEP also includes non-prototypic ancillary equipment to support the core processing.

  4. Pretreatment Engineering Platform (PEP) Integrated Test B Run Report--Caustic and Oxidative Leaching in UFP-VSL-T02A

    International Nuclear Information System (INIS)

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed and operated as part of a plan to respond to issue M12, 'Undemonstrated Leaching Processes' of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. The PEP also includes non-prototypic ancillary equipment to support the core processing.

  5. A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment.

    Science.gov (United States)

    Li, Yu-Jung; Lu, Chih-Cheng

    2015-01-01

    A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through maxillary bone marrow becomes achievable through the dental implant platform. The new pathway of biological sensing is for the first time presented to realize an accurate and painless approach without injections. The dental implant system mainly consists of an implant fixture and a prosthetic abutment, a biosensor module, a bluetooth 4.0 wireless module and a dc button cell battery. The electrochemical biosensor possesses three electrodes, including working, reference and counter ones, which are arranged to pass through the titanium implant fixture below the biosensor module. The electrodes are exposed to the blood pool inside the maxillary bone marrow and perform oxidation/reduction reactions with the coating of biosensing enzyme. To prove the proposed platform, the immobilization process of glucose oxidase (GOD) enzyme and in vitro detections of glucose levels are successfully carried out, and proven sensitivity, linearity and repeatability of the glucose biosensor system are obtained. Moreover, a preliminary canine animal model adopting the new pathway shows significant consistency with the traditional method through dermal pricks for blood sugar detection. Despite the prospective results, further challenges in engineering implementation and clinical practices are addressed and discussed. In brief, the novel biosensing pathway and intra-oral biosensor platform may increasingly reveal their promising value and feasibilities in current bio-medical analysis, diagnosis, drug

  6. A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment

    Directory of Open Access Journals (Sweden)

    Yu-Jung Li

    2015-09-01

    Full Text Available A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through maxillary bone marrow becomes achievable through the dental implant platform. The new pathway of biological sensing is for the first time presented to realize an accurate and painless approach without injections. The dental implant system mainly consists of an implant fixture and a prosthetic abutment, a biosensor module, a bluetooth 4.0 wireless module and a dc button cell battery. The electrochemical biosensor possesses three electrodes, including working, reference and counter ones, which are arranged to pass through the titanium implant fixture below the biosensor module. The electrodes are exposed to the blood pool inside the maxillary bone marrow and perform oxidation/reduction reactions with the coating of biosensing enzyme. To prove the proposed platform, the immobilization process of glucose oxidase (GOD enzyme and in vitro detections of glucose levels are successfully carried out, and proven sensitivity, linearity and repeatability of the glucose biosensor system are obtained. Moreover, a preliminary canine animal model adopting the new pathway shows significant consistency with the traditional method through dermal pricks for blood sugar detection. Despite the prospective results, further challenges in engineering implementation and clinical practices are addressed and discussed. In brief, the novel biosensing pathway and intra-oral biosensor platform may increasingly reveal their promising value and feasibilities in current bio-medical analysis

  7. A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

    OpenAIRE

    ThomasEissing

    2011-01-01

    Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multi-scale by nature, project work and software tools usually focus on isolated aspects of drug action, such as pharmacokinetics at the organism scale or pharmacodynamic interaction on the molecular level. We present a modeling and simulation software platform co...

  8. Development of an integrated Information Technology System for management of laboratory data and next-generation sequencing workflows within a cancer genomics research platform

    OpenAIRE

    Voegele, Catherine

    2015-01-01

    The aim of my thesis work was to develop bioinformatics tools to improve the traditional scientific information management within a large research centre and especially within a genomics platform. Three tools have been developed: an electronic laboratory notebook, a laboratory information management system for genomics applications including next generation sequencing, as well as a sample management system for large biobanks. This work has been conducted in close collaboration with biologists...

  9. Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration

    OpenAIRE

    Sohal, Davendra; Yeatts, Andrew; Ye, Kenny; Pellagatti, Andrea; Zhou, Li; Pahanish, Perry; Mo, Yongkai; Bhagat, Tushar; Mariadason, John; Boultwood, Jacqueline; Melnick, Ari; Greally, John; Verma, Amit

    2008-01-01

    Microarray-based studies of global gene expression (GE) have resulted in a large amount of data that can be mined for further insights into disease and physiology. Meta-analysis of these data is hampered by technical limitations due to many different platforms, gene annotations and probes used in different studies. We tested the feasibility of conducting a meta-analysis of GE studies to determine a transcriptional signature of hematopoietic progenitor and stem cells. Data from studies that us...

  10. A Novel Scheme and Evaluations on a Long-Term and Continuous Biosensor Platform Integrated with a Dental Implant Fixture and Its Prosthetic Abutment

    OpenAIRE

    Yu-Jung Li; Chih-Cheng Lu

    2015-01-01

    A miniature intra-oral dental implant system including a built-in biosensor device is proposed in this article. The dental implant system, or platform, is replaced over maxilla and allows relatively non-invasive procedures for a novel biosensing scheme for human blood analysis. Due to placement of the implant fixture, periodontal ligaments and the pulp structure, which are regarded as the main origin of pain, are thus removed, and long-term, continuous blood analysis and management through ma...

  11. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  12. SNMP management of MASIF platforms

    OpenAIRE

    Lopes, Rui Pedro; Oliveira, José Luís

    2001-01-01

    In this paper we describe the architecture, the development and the assessment results of an SNMP agent that allows MASIF compliant platforms to be managed through SNMP. The major outcome of this work is a simple integration of mobile agent technology with any well-established commercial network management system.

  13. Measures of Biochemical Sociology

    Science.gov (United States)

    Snell, Joel; Marsh, Mitchell

    2008-01-01

    In a previous article, the authors introduced a new sub field in sociology that we labeled "biochemical sociology." We introduced the definition of a sociology that encompasses sociological measures, psychological measures, and biological indicators Snell & Marsh (2003). In this article, we want to demonstrate a research strategy that would assess…

  14. Biochemical Education in Brazil.

    Science.gov (United States)

    Vella, F.

    1988-01-01

    Described are discussions held concerning the problems of biochemical education in Brazil at a meeting of the Sociedade Brazileira de Bioquimica in April 1988. Also discussed are other visits that were made to universities in Brazil. Three major recommendations to improve the state of biochemistry education in Brazil are presented. (CW)

  15. Product Platform Performance

    DEFF Research Database (Denmark)

    Munk, Lone

    experienced representatives from the different life systems phase systems of the platform products. The effects are estimated and modeled within different scenarios, taking into account financial and real option aspects. The model illustrates and supports estimation and quantification of internal platform....... These reasons are mentioned in literature, but only the two latter are addressed in platform assessment criteria. Hence a new platform assessment criterion is introduced, the platform user incentive criterion. Alongside with the introduction and recommendation of a platform user incentive criterion...

  16. 小型船舶综合全电力推进实验平台的研制%Development of Experimental Platform for the Small Marine Integrated Electric Propulsion System

    Institute of Scientific and Technical Information of China (English)

    李俊科; 俞万能; 严华

    2012-01-01

    介绍了小型船舶综合电力推进实验平台的机械和电气设计方案及相应的系统控制模型.平台主要由推进、模拟负载和测量三个子系统组成.推进系统主要由变频驱动装置、操作监控台、推进电机构成;模拟负载系统由交流电动机、四象限变频驱动装置、监控系统及负载模型软件组成;测量系统由转速传感器、转矩传感器以及PLC组成.%The mechanical and electrical design proposal and the corresponding system control madel of a small experiment platform for the marine integrated electric propulsion system were introduced in this paper.The platform was mainly composed of three subsystems including propulsion system,simulated load system and measuringe system.The propulsion system was composed mainly of a variable-frequency driving device,an operating and monitor console and a propulsion motor;The simulated load system was mainly composed of an AC motor,a four quadrant variable-frequency driving device,a monitoring system and a load model software;The measuring system was composed of a speed sensor,a torque sensor and PLC controllers.The successful development of the experimental platform will provide a good tool for teaching and research of the integrated electric propulsion system.

  17. The Innovative Capabilities Of Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol

    2015-01-01

    the support for open innovation. The proposed model has been employed in a comparative case study between two digital payment platforms: Apple Pay and Google Wallet. The findings suggest that digital payment platforms make use of boundary resources to be highly integrative or integratable, which supports...

  18. The Geohazards Exploitation Platform

    Science.gov (United States)

    Laur, Henri; Casu, Francesco; Bally, Philippe; Caumont, Hervé; Pinto, Salvatore

    2016-04-01

    The Geohazards Exploitation Platform, or Geohazards TEP (GEP), is an ESA originated R&D activity of the EO ground segment to demonstrate the benefit of new technologies for large scale processing of EO data. This encompasses on-demand processing for specific user needs, systematic processing to address common information needs of the geohazards community, and integration of newly developed processors for scientists and other expert users. The platform supports the geohazards community's objectives as defined in the context of the International Forum on Satellite EO and Geohazards organised by ESA and GEO in Santorini in 2012. The GEP is a follow on to the Supersites Exploitation Platform (SSEP) an ESA initiative to support the Geohazards Supersites & Natural Laboratories initiative (GSNL). Today the GEP allows to exploit 70+ Terabyte of ERS and ENVISAT archive and the Copernicus Sentinel-1 data available on line. The platform has already engaged 22 European early adopters in a validation activity initiated in March 2015. Since September, this validation has reached 29 single user projects. Each project is concerned with either integrating an application, running on demand processing or systematically generating a product collection using an application available in the platform. The users primarily include 15 geoscience centres and universities based in Europe: British Geological Survey (UK), University of Leeds (UK), University College London (UK), ETH University of Zurich (CH), INGV (IT), CNR-IREA and CNR-IRPI (IT), University of L'Aquila (IT), NOA (GR), Univ. Blaise Pascal & CNRS (FR), Ecole Normale Supérieure (FR), ISTERRE / University of Grenoble-Alpes (FR). In addition, there are users from Africa and North America with the University of Rabat (MA) and the University of Miami (US). Furthermore two space agencies and four private companies are involved: the German Space Research Centre DLR (DE), the European Space Agency (ESA), Altamira Information (ES

  19. DockBench: An Integrated Informatic Platform Bridging the Gap between the Robust Validation of Docking Protocols and Virtual Screening Simulations

    Directory of Open Access Journals (Sweden)

    Alberto Cuzzolin

    2015-05-01

    Full Text Available Virtual screening (VS is a computational methodology that streamlines the drug discovery process by reducing costs and required resources through the in silico identification of potential drug candidates. Structure-based VS (SBVS exploits knowledge about the three-dimensional (3D structure of protein targets and uses the docking methodology as search engine for novel hits. The success of a SBVS campaign strongly depends upon the accuracy of the docking protocol used to select the candidates from large chemical libraries. The identification of suitable protocols is therefore a crucial step in the setup of SBVS experiments. Carrying out extensive benchmark studies, however, is usually a tangled task that requires users’ proficiency in handling different file formats and philosophies at the basis of the plethora of existing software packages. We present here DockBench 1.0, a platform available free of charge that eases the pipeline by automating the entire procedure, from docking benchmark to VS setups. In its current implementation, DockBench 1.0 handles seven docking software packages and offers the possibility to test up to seventeen different protocols. The main features of our platform are presented here and the results of the benchmark study of human Checkpoint kinase 1 (hChk1 are discussed as validation test.

  20. Multiplexing oscillatory biochemical signals.

    Science.gov (United States)

    de Ronde, Wiet; ten Wolde, Pieter Rein

    2014-04-01

    In recent years it has been increasingly recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier. Moreover, it is now well established that the protein signaling network of living cells has a bow-tie structure and that components are often shared between different signaling pathways. Here we show by mathematical modeling that living cells can multiplex a constant and an oscillatory signal: they can transmit these two signals simultaneously through a common signaling pathway, and yet respond to them specifically and reliably. We find that information transmission is reduced not only by noise arising from the intrinsic stochasticity of biochemical reactions, but also by crosstalk between the different channels. Yet, under biologically relevant conditions more than 2 bits of information can be transmitted per channel, even when the two signals are transmitted simultaneously. These observations suggest that oscillatory signals are ideal for multiplexing signals. PMID:24685537

  1. UNIVERSITY TECHNOLOGY PLATFORM OF ANTICIPATORY LEARNING

    OpenAIRE

    GITELMAN LEONID DAVIDOVICH; SANDLER DANIIL GENNADYEVICH; KOZHEVNIKOV MIKHAIL VIKTOROVICH

    2016-01-01

    The innovative development sets large-scale and challenging tasks, which need to be addressed in the lack-of-knowledge conditions and require the coordination and integration of numerous expert structures, which are scattered around the world and have different status and competencies. One of the mechanisms of integrating the partners’ intellectual and financial resources is provided by the technology platforms. The article discusses the nature and functions of technology platforms and analyz...

  2. SU-E-J-04: Integration of Interstitial High Intensity Therapeutic Ultrasound Applicators On a Clinical MRI-Guided High Intensity Focused Ultrasound Treatment Planning Software Platform

    International Nuclear Information System (INIS)

    Purpose: Interstitial high intensity therapeutic ultrasound (HITU) applicators can be used to ablate tissue percutaneously, allowing for minimally-invasive treatment without ionizing radiation [1,2]. The purpose of this study was to evaluate the feasibility and usability of combining multielement interstitial HITU applicators with a clinical magnetic resonance imaging (MRI)-guided focused ultrasound software platform. Methods: The Sonalleve software platform (Philips Healthcare, Vantaa, Finland) combines anatomical MRI for target selection and multi-planar MRI thermometry to provide real-time temperature information. The MRI-compatible interstitial US applicators (Acoustic MedSystems, Savoy, IL, USA) had 1–4 cylindrical US elements, each 1 cm long with either 180° or 360° of active surface. Each applicator (4 Fr diameter, enclosed within a 13 Fr flexible catheter) was inserted into a tissue-mimicking agar-silica phantom. Degassed water was circulated around the transducers for cooling and coupling. Based on the location of the applicator, a virtual transducer overlay was added to the software to assist targeting and to allow automatic thermometry slice placement. The phantom was sonicated at 7 MHz for 5 minutes with 6–8 W of acoustic power for each element. MR thermometry data were collected during and after sonication. Results: Preliminary testing indicated that the applicator location could be identified in the planning images and the transducer locations predicted within 1 mm accuracy using the overlay. Ablation zones (thermal dose ≥ 240 CEM43) for 2 active, adjacent US elements ranged from 18 mm × 24 mm (width × length) to 25 mm × 25 mm for the 6 W and 8 W sonications, respectively. Conclusion: The combination of interstitial HITU applicators and this software platform holds promise for novel approaches in minimally-invasive MRI-guided therapy, especially when bony structures or air-filled cavities may preclude extracorporeal HIFU.[1] Diederich et al

  3. SU-E-J-04: Integration of Interstitial High Intensity Therapeutic Ultrasound Applicators On a Clinical MRI-Guided High Intensity Focused Ultrasound Treatment Planning Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, N [Johns Hopkins University, Baltimore, Maryland (United States); Partanen, A [Philips Healthcare, Andover, Massachusetts (United States); Ghoshal, G; Burdette, E [Acoustic MedSystems Inc., Savoy, IL (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: Interstitial high intensity therapeutic ultrasound (HITU) applicators can be used to ablate tissue percutaneously, allowing for minimally-invasive treatment without ionizing radiation [1,2]. The purpose of this study was to evaluate the feasibility and usability of combining multielement interstitial HITU applicators with a clinical magnetic resonance imaging (MRI)-guided focused ultrasound software platform. Methods: The Sonalleve software platform (Philips Healthcare, Vantaa, Finland) combines anatomical MRI for target selection and multi-planar MRI thermometry to provide real-time temperature information. The MRI-compatible interstitial US applicators (Acoustic MedSystems, Savoy, IL, USA) had 1–4 cylindrical US elements, each 1 cm long with either 180° or 360° of active surface. Each applicator (4 Fr diameter, enclosed within a 13 Fr flexible catheter) was inserted into a tissue-mimicking agar-silica phantom. Degassed water was circulated around the transducers for cooling and coupling. Based on the location of the applicator, a virtual transducer overlay was added to the software to assist targeting and to allow automatic thermometry slice placement. The phantom was sonicated at 7 MHz for 5 minutes with 6–8 W of acoustic power for each element. MR thermometry data were collected during and after sonication. Results: Preliminary testing indicated that the applicator location could be identified in the planning images and the transducer locations predicted within 1 mm accuracy using the overlay. Ablation zones (thermal dose ≥ 240 CEM43) for 2 active, adjacent US elements ranged from 18 mm × 24 mm (width × length) to 25 mm × 25 mm for the 6 W and 8 W sonications, respectively. Conclusion: The combination of interstitial HITU applicators and this software platform holds promise for novel approaches in minimally-invasive MRI-guided therapy, especially when bony structures or air-filled cavities may preclude extracorporeal HIFU.[1] Diederich et al

  4. 计算机集成激光三维增材成形制造平台%Laser Three-dimensional Additive Forming Manufacturing Platform by Computer Integrating for LCD-SLM-SLS

    Institute of Scientific and Technical Information of China (English)

    颜永年; 荆红; 张定军; 陈振东

    2014-01-01

    将激光熔覆沉积(LCD)和选择性激光熔化/烧结(SLM/S)两类最重要的金属增材成形技术中的CAD模型、分层与路径规划、工艺参数和激光使能系统等相关信息和异构数据,通过采用CIMS的技术原理和系统集成方法,构建了L-SS(LCD-SLM/S)激光增材成形平台,实现了在计算机管控下,将信息数据资源与多台3D打印设备、激光器的优化配置,大大提高了信息共享度、资源利用率和节能效率。%LCD (laser cladding deposition) and SLM/S (selective laser melting/sintering) are two kinds of the most important metal addictive forming technologies. In the paper ,it was proposed that the Laser addictive forming platform was built based on all information and heterogeneous data about the CAD model,layering,path planning,parameters of process and Laser System by using the technology principle and system integration methods of CIMS (computer integrated manufacturing system). The L-SS (LCD-SLM/S) platform integrates all data ,optimizes 3D-printer and laser devices under the control of computer and greatly improves the degree of information sharing ,the ratio of information utilization and energy efficiency.

  5. Reinventing the Platform Core Through Acquisition

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan; Eaton, Ben

    2016-01-01

    acquisition and integration of companies presenting innovative technologies of relevance to the platform core. Using a revelatory case study of Cisco Systems, we develop the explanatory notion of ‘coring acquisition’. In this type of acquisition value is created through the acquisition of companies that......Digital platform leaders need to continuously innovate the platform core to drive the technological trajectory of the overall architecture and business system, of which the platform is a core element. This papers analyses the potential of and challenges to completing this task through the...... provide products external to the acquirer that can be assimilated into the platform core. This creates value through the transformational process that we term ‘coring’. We also analyze how the benefits of coring acquisitions are contingent on challenges concerning the integration of acquisitions offering...

  6. Design and Implementation of Principal and Subordinate Model Institution Group Integration Knowledge Platform%主从模式研究所群组集成知识平台设计与实现

    Institute of Scientific and Technical Information of China (English)

    刘毅; 王峰; 周子健

    2012-01-01

    This paper puts forward a solution of the institution group integration knowledge platform based on principal and subordinate model after analyzing the open source project Liferay. Several independent group platforms are harmoniously in- tegrated into an institutional knowledge service network using such technologies as information extraction, customized push, RSS aggregation and interface acquisition. Finally, the main method of secondary development is introduced.%在分析开源项目Liferay基础上,提出主从模式研究所群组集成知识平台设计方案,利用信息抽取、定制推送、RSS聚合、接口获取等方式整合多个独立的课题组平台信息,形成新的研究所知识服务网络,最后介绍系统二次开发的主要方法。

  7. High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining

    International Nuclear Information System (INIS)

    Circulating tumor cells (CTCs) are malignant cells that have migrated from solid cancers into the blood, where they are typically present in rare numbers. There is great interest in using CTCs to monitor response to therapies, to identify clinically actionable biomarkers, and to provide a non-invasive window on the molecular state of a tumor. Here we characterize the performance of the AccuCyte® – CyteFinder® system, a comprehensive, reproducible and highly sensitive platform for collecting, identifying and retrieving individual CTCs from microscopic slides for molecular analysis after automated immunofluorescence staining for epithelial markers. All experiments employed a density-based cell separation apparatus (AccuCyte) to separate nucleated cells from the blood and transfer them to microscopic slides. After staining, the slides were imaged using a digital scanning microscope (CyteFinder). Precisely counted model CTCs (mCTCs) from four cancer cell lines were spiked into whole blood to determine recovery rates. Individual mCTCs were removed from slides using a single-cell retrieval device (CytePicker™) for whole genome amplification and subsequent analysis by PCR and Sanger sequencing, whole exome sequencing, or array-based comparative genomic hybridization. Clinical CTCs were evaluated in blood samples from patients with different cancers in comparison with the CellSearch® system. AccuCyte – CyteFinder presented high-resolution images that allowed identification of mCTCs by morphologic and phenotypic features. Spike-in mCTC recoveries were between 90 and 91%. More than 80% of single-digit spike-in mCTCs were identified and even a single cell in 7.5 mL could be found. Analysis of single SKBR3 mCTCs identified presence of a known TP53 mutation by both PCR and whole exome sequencing, and confirmed the reported karyotype of this cell line. Patient sample CTC counts matched or exceeded CellSearch CTC counts in a small feasibility cohort. The AccuCyte

  8. Towards a Service-Oriented Enterprise: The Design of a Cloud Business Integration Platform in a Medium-Sized Manufacturing Enterprise

    Science.gov (United States)

    Stamas, Paul J.

    2013-01-01

    This case study research followed the two-year transition of a medium-sized manufacturing firm towards a service-oriented enterprise. A service-oriented enterprise is an emerging architecture of the firm that leverages the paradigm of services computing to integrate the capabilities of the firm with the complementary competencies of business…

  9. 引供水工程自动监测系统集成平台的通信与控制%Communication and Remote Control of Integration Platform for Automatic Monitoring System on Water Diversion Project

    Institute of Scientific and Technical Information of China (English)

    高磊; 郑健兵; 徐骏; 陈意

    2011-01-01

    介绍了引供水工程自动化以及其测量子系统,提出了基于统一信息分析查询集成平台的设备监控集成方案,论述了通信与控制集成的原理、结构及流程,分析了该设计的特点与控制机理,为引供水工程的子系统操控集成提供了一套可行的设计与架构.%An automation of water diversion project and its measurement subsystem is mainly introduced. And integration platform based on the unity information query and analysis for the scheme of device monitoring and control is presented. The principle, structure and process of the integration for communication and control are discussed. Besides, the features and control mechanism of the design pattern are analyzed. It offers a feasible design and architecture for integration and monitoring subsystem of water diversion project.

  10. Optimization of a Common Buffer Platform for Monolithic Integration of InGaN/GaN Light-Emitting Diodes and AlGaN/GaN High-Electron-Mobility Transistors

    Science.gov (United States)

    Liu, Chao; Cai, Yuefei; Jiang, Huaxing; Lau, Kei May

    2016-04-01

    For the development of a metal-interconnection-free integration scheme for monolithic integration of InGaN/GaN light-emitting diodes (LEDs) and AlGaN/GaN high-electron-mobility transistors (HEMTs), a common buffer to achieve high brightness, low leakage current, and high breakdown in the integrated HEMT-LED device is essential. Different buffer structures have been investigated, and their impacts upon both the LED and HEMT parts of the HEMT-LED device have been analyzed. Results indicated that a GaN/AlN buffer structure is the most ideal to serve as a common buffer platform, offering both the excellent crystalline quality and superior buffer resistivity required by the HEMT-LED device. Growth of the AlN layer was particularly crucial for engineering the dislocation density, surface morphology, as well as resistivity of the buffer layer. Using the optimized GaN/AlN buffer structure, the LED part of the HEMT-LED device was improved, showing greatly enhanced light output power and suppressed reverse leakage current, while the breakdown characteristics of the HEMT part were also improved.

  11. The Research of Internet-based Robot Design Platform

    OpenAIRE

    Zhenhua Liu; Jinjie Chen

    2011-01-01

    A robot design platform is built to integrate human resources and projects resources. It can achieve cooperative and parallel development. The platform includes project management, human resource management, requirement management and other modules. Framework proposed in this paper is that the foundation for the development platform.

  12. Three-dimensional system integration for HUD placement on a new tactical airlift platform: design eye point vs. HUD eye box with accommodation and perceptual implications

    Science.gov (United States)

    Harbour, Steven D.; Hudson, Jeffery A.; Zehner, Gregory F.

    2012-06-01

    The retrofitting of a cockpit with a Head-Up-Display (HUD) raises potential accommodation and perceptual issues for pilots that must be addressed. For maximum optical efficiency, the goal is to be able to place every pilot's eye into the HUD Eye Motion Box (EMB) given a seat adjustment range. Initially, the Eye Reference Point (ERP) of the EMB should theoretically be located on the aircraft's original cockpit Design Eye Point (DEP), but human postures vary, and HUD systems may not be optimally placed. In reality, there is a distribution of pilot eyes around the DEP (which is dominant eye dependent); therefore, this must be accounted for in order to obtain appropriate visibility of all of the symbology based on photonic characteristics of the HUD. Pilot size and postural variation need to be taken into consideration when positioning the HUD system to ensure proper vision of all HUD symbology in addition to meeting the basic physical accommodation requirements of the cockpit. The innovative process and data collection methods for maximizing accommodation and pilot perception on a new "tactical airlift" platform are discussed as well as the related neurocognitive factors and the effects of information display design on cognitive phenomena.

  13. 基于BIM平台的集成化可持续建筑设计教学研究%A Study of the Teaching of Integrated Sustainable Building Design Based on the BIM Platform

    Institute of Scientific and Technical Information of China (English)

    解明镜; 石磊; 罗明

    2012-01-01

    通过对我国建筑设计教育现状的分析,指出基于线性设计模式和单一学科平台的教育模式已不能满足可持续建筑设计需求,基于集成化设计模式和跨学科设计平台的教学方式更适应社会的需求和学生设计能力的培养,而BIM平台能够为集成化设计模式提供软件平台,满足教学要求。通过在教学团队、教学方法、教学内容和教学时间上的改进与实践,教学改革收到良好效果,学生设计能力与专业内认可程度都有较大提高,在全国学科竞赛中成绩优异。%Based on the analysis of the status of architectural education, the liner design model and the singleness disciplinary educational model are founded unsuitable for the requirements of sustainable building design. The new teaching pattern, based on the integrated design model and multi-disciplinary design platform, is more effective for the design capacity training of undergraduates. BIM (Building information model) can afford the software platform for the integrated design model and meet the requirements of the society. By the improvements and practices on the teaching methodology, contents, teaching team and teaching time, the teaching reformation is successful. The design capacity of the undergraduates is improved, and many students win the awards from the national course contests.

  14. Ship 3D Collaborative Design Workflow Research Based on Integrated Platform%基于集成平台的船舶三维协同设计流程研究

    Institute of Scientific and Technical Information of China (English)

    苏绍娟; 刘寅东; 刘晓明

    2011-01-01

    At first, the characteristics of modern ship design and manufacture and the existing limitations with information technology development is analyzed.On the base the need for parallel and collaborative design is put forward.At the same time collaborative design management software Windchill is in-depth studied and application, Integrated platform with 3D design software Solidworks and management software Windchill through middleware software is constructed and its key technologies is aralyzed.3D design workflow combining example of ship design is carried out.The integrated platform can create conditions for further implementation of the design process in parallel, dynamic, realtime control.%分析了现代船舶设计制造的特点及随着信息化的发展而存在的一些局限性,在此基础上分析了进行并行协同设计的必要性.同时对协同设计管理软件windchill进行了深入的研究和应用,通过中间件构建了三维设计软件SolidWorks与windchill的集成平台,并分析了其关键技术.结合船舶设计实例实现了三维协同设计的工作流程,为进一步对设计过程实施并行、动态、实时控制创造了条件.

  15. Segway robotic mobility platform

    Science.gov (United States)

    Nguyen, Hoa G.; Morrell, John; Mullens, Katherine D.; Burmeister, Aaron B.; Miles, Susan; Farrington, Nathan; Thomas, Kari M.; Gage, Douglas W.

    2004-12-01

    The Segway Robotic Mobility Platform (RMP) is a new mobile robotic platform based on the self-balancing Segway Human Transporter (HT). The Segway RMP is faster, cheaper, and more agile than existing comparable platforms. It is also rugged, has a small footprint, a zero turning radius, and yet can carry a greater payload. The new geometry of the platform presents researchers with an opportunity to examine novel topics, including people-height sensing and actuation modalities. This paper describes the history and development of the platform, its characteristics, and a summary of current research projects involving the platform at various institutions across the United States.

  16. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    , while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions of...

  17. Biochemical Hypermedia: Galactose Metabolism.

    Directory of Open Access Journals (Sweden)

    J.K. Sugai

    2013-05-01

    Full Text Available Introduction: Animations of biochemical processes and virtual laboratory environments lead to true molecular simulations. The use of interactive software’s in education can improve cognitive capacity, better learning and, mainly, it makes information acquisition easier. Material and Methods: This work presents the development of a biochemical hypermedia to understanding of the galactose metabolism. It was developed with the help of concept maps, ISIS Draw, ADOBE Photoshop and FLASH MX Program. Results and Discussion: A step by step animation process shows the enzymatic reactions of galactose conversion to glucose-1-phosphate (to glycogen synthesis, glucose-6-phosphate (glycolysis intermediary, UDP-galactose (substrate to mucopolysaccharides synthesis and collagen’s glycosylation. There are navigation guide that allow scrolling the mouse over the names of the components of enzymatic reactions of via the metabolism of galactose. Thus, explanatory text box, chemical structures and animation of the actions of enzymes appear to navigator. Upon completion of the module, the user’s response to the proposed exercise can be checked immediately through text box with interactive content of the answer. Conclusion: This hypermedia was presented for undergraduate students (UFSC who revealed that it was extremely effective in promoting the understanding of the theme.

  18. A micro-chip initiator with controlled combustion reactivity realized by integrating Al/CuO nanothermite composites on a microhotplate platform

    International Nuclear Information System (INIS)

    The interfacial contact area between the fuel and oxidizer components plays an important role in determining the combustion reactivity of nanothermite composites. In addition, the development of compact and reliable ignition methods can extend the applicability of nanothermite composites to various thermal engineering fields. In this study we report the development of a micro-chip initiator with controlled combustion reactivity using concepts usually applied to microelectromechanical systems (MEMS) and simple nanofabrication processes. The nanothermite composites fabricated in this study consisted of aluminum nanoparticles (Al NPs) as the fuel and copper oxide nanoparticles (CuO NPs) as the oxidizer accumulated on a silicon oxide substrate with a serpentine-shaped gold (Au) electrode. The micro-chip initiator rapidly ignited and exploded when minimal current was supplied. The effects of stacking structures of Al and CuO-based multilayers on the combustion properties were systematically investigated in terms of the pressurization rate, peak explosion time, and heat flow. Pressurization rates of 0.004–0.025 MPa μs−1 and heat flows of 2.0–3.8 kJ g−1 with a commonly fast response time of less than 20 ms could be achieved by simply changing the interfacial structures of the Al and CuO multilayers. The controllability of combustion reactivity of micro-chip initiator can be made for general nanothermite composites composed of Al and various metal oxides (e.g. Fe2O3, CuO, KMnO4, etc). The micro-chip initiator fabricated in this study was reliable, compact, and proved to be a versatile platform, exhibiting controlled combustion reactivity and fast response time, which could be used for various civilian and military thermal engineering applications, such as in initiators and propulsion, welding, and ordinance systems. (paper)

  19. A micro-chip initiator with controlled combustion reactivity realized by integrating Al/CuO nanothermite composites on a microhotplate platform

    Science.gov (United States)

    Ahn, Ji Young; Kim, Sang Beom; Kim, Ji Hoon; Jang, Nam Su; Kim, Dae Hyun; Lee, Hyung Woo; Kim, Jong Man; Kim, Soo Hyung

    2016-01-01

    The interfacial contact area between the fuel and oxidizer components plays an important role in determining the combustion reactivity of nanothermite composites. In addition, the development of compact and reliable ignition methods can extend the applicability of nanothermite composites to various thermal engineering fields. In this study we report the development of a micro-chip initiator with controlled combustion reactivity using concepts usually applied to microelectromechanical systems (MEMS) and simple nanofabrication processes. The nanothermite composites fabricated in this study consisted of aluminum nanoparticles (Al NPs) as the fuel and copper oxide nanoparticles (CuO NPs) as the oxidizer accumulated on a silicon oxide substrate with a serpentine-shaped gold (Au) electrode. The micro-chip initiator rapidly ignited and exploded when minimal current was supplied. The effects of stacking structures of Al and CuO-based multilayers on the combustion properties were systematically investigated in terms of the pressurization rate, peak explosion time, and heat flow. Pressurization rates of 0.004-0.025 MPa μs-1 and heat flows of 2.0-3.8 kJ g-1 with a commonly fast response time of less than 20 ms could be achieved by simply changing the interfacial structures of the Al and CuO multilayers. The controllability of combustion reactivity of micro-chip initiator can be made for general nanothermite composites composed of Al and various metal oxides (e.g. Fe2O3, CuO, KMnO4, etc). The micro-chip initiator fabricated in this study was reliable, compact, and proved to be a versatile platform, exhibiting controlled combustion reactivity and fast response time, which could be used for various civilian and military thermal engineering applications, such as in initiators and propulsion, welding, and ordinance systems.

  20. GPS Tracker Data Analysis Platform

    OpenAIRE

    Belay, Tinbit

    2015-01-01

    This thesis work offers GPS tracking solutions which provides detailed reporting on the tracked assets while significantly reducing costs. Despite the fact that GPS trackers are used as a security mechanism. The objective of this thesis was to develop a web platform for gathering the be-havioral aspects of the tracked assets. The thesis work was designed and imple-mented using Groovy-based web application framework, which integrates smooth-ly with the JVM. The user interface was implement...

  1. The Study of Target Tracking Based on ARM Embedded Platform

    Directory of Open Access Journals (Sweden)

    Xiaoming Liu

    2012-08-01

    Full Text Available This article explored a solution of target tracking based on the ARM embedded platform, which gave a design and realization of removable image processing equipment to detect and track the pedestrian in the video. The integration level of embedded platform is very high, embedded platform supports real-time multitasking operating system, and comply with the requirements of real-time and miniaturization. Studying how to combine embedded platform with target tracking, it has instructional significance for robot development applications.

  2. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  3. Platform development supportedby gaming

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan; Hansen, Poul H. Kyvsgård

    2007-01-01

    The challenge of implementing industrial platforms in practice can be described as a configuration problem caused by high number of variables, which often have contradictory influences on the total performance of the firm. Consequently, the specific platform decisions become extremely complex......, based on the portfolio management thinking, to measure the degree of modularity embedded in a given platform and to what extent it is aligned with other platforms....

  4. Research and Implementation of Sodium-Cooled Fast Reactor Engineering SOA Integration Platform Based Upon Information System%基于SOA的钠冷快堆工程信息系统集成平台的研究和实现

    Institute of Scientific and Technical Information of China (English)

    李健

    2014-01-01

    This paper analyzes the implementation of integrated technology and its limitations exist in the current construction of nuclear power construction management system, and for the sodium cooled fast reactor construction management features, proposed to build SOA-based cold sodium fast reactor engineering information system integration platform (hereinafter referred to as "integration Platform") design ideas. System integration platform for business functions, and system integration theory, the concepts of SOA, analysis and design in-depth study on the basis of the design of the overall structure of the sodium cooled fast reactor engineering information system integration platform, and discusses in detail the integrated platform-specific implementation process.%本文主要分析了当前核电建造施工管理系统集成的实现技术及其存在的局限性,并针对钠冷快堆的施工管理特点,提出了构建基于SOA的钠冷快堆工程信息系统集成平台(以下简称“集成平台”)的设计思想。对集成平台的业务功能体系、系统集成的理论、SOA的相关概念、分析与设计进行了深入研究,在此基础上设计了钠冷快堆工程信息系统集成平台的总体架构,并详细论述了集成平台的具体实现过程。

  5. ITS Platform North Denmark

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Agerholm, Niels; Juhl, Jens;

    2012-01-01

    designed digital road map for ITS applications. The platform is freely accessible, which means that third party applications could be run on the platform. It is estimated that using this platform enables the ITS applications to be developed for 20% of the normal cost, hence third party are invited to test...

  6. Analysis of Building a Powerful Integrated Monitoring Platform of Radio and Television%建设综合强大的广播电视监管平台浅析

    Institute of Scientific and Technical Information of China (English)

    崔杰辉

    2011-01-01

    建设综合强大的广播电视监管平台,具有重要的作用和现实的意义,同时也是我国广播电视生产力发展水平的客观现实和要求。应建立类别清晰、内容广泛、技术先进的广播电视综合监测系统,为依法科学管理广播电视奠定坚实的基础。%The construction of an integrated monitoring platform for radio and television not only has an important role but a great significance,as well as objective realities and requirements of China's radio and television productivity development.To provide a solid foundation for the scientific management according to law,we should construct a classifying,wide-ranging and technical advanced integrated monitoring system for radio and television.

  7. Efficient extraction of zero-phonon-line photons from single nitrogen-vacancy centers in an integrated GaP-on-diamond platform

    CERN Document Server

    Gould, Michael; Dadgostar, Shabnam; Hatami, Fariba; Fu, Kai-Mei C

    2016-01-01

    Scaling beyond two-node quantum networks using nitrogen vacancy (NV) centers in diamond is limited by the low probability of collecting zero phonon line (ZPL) photons from single centers. Here, we demonstrate GaP-on-diamond disk resonators which resonantly couple ZPL photons from single NV centers to single-mode waveguides. In these devices, the probability of a single NV center emitting a ZPL photon into the guided waveguide mode after optical excitation can reach 9%, due to a combination of resonant enhancement of the ZPL emission and efficient coupling between the resonator and waveguide. We verify the single-photon nature of the emission and experimentally demonstrate both high in-waveguide photon numbers and substantial Purcell enhancement for a set of devices. These devices may enable scalable integrated quantum networks based on NV centers.

  8. TH-C-17A-12: Integrated CBCT and Optical Tomography System On-Board a Small Animal Radiation Research Platform (SARRP)

    International Nuclear Information System (INIS)

    Purpose: We present a newly developed on-board optical tomography system for SARRP. Innovative features include the compact design and fast acquisition optical method to perform 3D soft tissue radiation guidance. Because of the on-board feature and the combination of the CBCT, diffusive optical tomography (DOT), bioluminescence and fluorescence tomography (BLT and FT), this integrated system is expected to provide more accurate soft tissue guidance than an off-line system as well as highly sensitive functional imaging in preclinical research. Methods: Images are acquired in the order of CBCT, DOT and then BLT/FT, where the SARRP CBCT and DOT are used to provide the anatomical and optical properties information to enhance the subsequent BLT/FT optical reconstruction. The SARRP stage is redesigned to include 9 imbedded optical fibers in contact with the animal's skin. These fibers, connected to a white light lamp or laser, serve as the light sources for the DOT or FT, respectively. A CCD camera with f/1.4 lens and multi-spectral filter set is used as the optical detector and is mounted on a portable cart ready to dock into the SARRP. No radiation is delivered during optical image acquisition. A 3-way mirror system capable of 180 degree rotation around the animal reflects the optical signal to the camera at multiple projection angles. A special black-painted dome covers the stage and provides the light shielding. Results: Spontaneous metastatic bioluminescent liver and lung tumor models will be used to validate the 3D BLT reconstruction. To demonstrate the capability of our FT system, GastroSense750 fluorescence agent will be used to imaging the mouse stomach and intestinal region in 3D. Conclusion: We expect that this integrated CBCT and optical tomography on-board a SARRP will present new research opportunities for pre-clinical radiation research. Supported by NCI RO1-CA 158100

  9. TH-C-17A-12: Integrated CBCT and Optical Tomography System On-Board a Small Animal Radiation Research Platform (SARRP)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, K; Zhang, B; Eslami, S; Iordachita, I; Wong, J [Johns Hopkins University, Baltimore, MD (United States); Patterson, M [Hamilton Regional Cancer Ctr., Hamilton, ON (Canada)

    2014-06-15

    Purpose: We present a newly developed on-board optical tomography system for SARRP. Innovative features include the compact design and fast acquisition optical method to perform 3D soft tissue radiation guidance. Because of the on-board feature and the combination of the CBCT, diffusive optical tomography (DOT), bioluminescence and fluorescence tomography (BLT and FT), this integrated system is expected to provide more accurate soft tissue guidance than an off-line system as well as highly sensitive functional imaging in preclinical research. Methods: Images are acquired in the order of CBCT, DOT and then BLT/FT, where the SARRP CBCT and DOT are used to provide the anatomical and optical properties information to enhance the subsequent BLT/FT optical reconstruction. The SARRP stage is redesigned to include 9 imbedded optical fibers in contact with the animal's skin. These fibers, connected to a white light lamp or laser, serve as the light sources for the DOT or FT, respectively. A CCD camera with f/1.4 lens and multi-spectral filter set is used as the optical detector and is mounted on a portable cart ready to dock into the SARRP. No radiation is delivered during optical image acquisition. A 3-way mirror system capable of 180 degree rotation around the animal reflects the optical signal to the camera at multiple projection angles. A special black-painted dome covers the stage and provides the light shielding. Results: Spontaneous metastatic bioluminescent liver and lung tumor models will be used to validate the 3D BLT reconstruction. To demonstrate the capability of our FT system, GastroSense750 fluorescence agent will be used to imaging the mouse stomach and intestinal region in 3D. Conclusion: We expect that this integrated CBCT and optical tomography on-board a SARRP will present new research opportunities for pre-clinical radiation research. Supported by NCI RO1-CA 158100.

  10. Study on Agricultural Distance Monitoring and Diagnosing Integration Platform Based on XMPP%基于XMPP的农业远程监测和诊断平台的研究

    Institute of Scientific and Technical Information of China (English)

    张卫; 于金莹; 于峰; 栾汝朋

    2011-01-01

    In order to solve distance monitoring and distance diagnosing in the process of agricultural production, this author used XMPP and Jingle which were XMPP expand protocol as transmission carrier to realize integration of agricultural environment factors monitoring, field distance-vision surveillance and expert distance-vision consultation. Platform used client/server structure. Plant environment factors depended on concentrator to transform data to XMPP format. Field distance-vision surveillance and expert distance-vision consultation transform instructions and text data relied on XMPP parsing module. Then these XMPP data were used to communicate with servers. Audio data and video data used Jingle protocol to communicate. Platform had been used in production safety of agricultural products. Agricultural environment factors monitoring, field distance-vision surveillance and expert distance-vision consultation in platform ensured production and quality of agricultural products.%为解决农业生产远程监测和远程咨询诊断问题,采用XMPP及其扩展协议Jingle,研发农业远程监测和咨询诊断于一体的综合平台,实现农业生产环境因子远程监测、生产现场远程视频监视和远程双向视频咨询诊断功能.平台采用客户端和服务器结构,农业生产环境因子远程监测依靠集中器把各指令和数据转换成XMPP格式,生产现场远程视频监视和远程双向视频咨询诊断通过XMPP解析模块把各指令和文本数据转换成XMPP格式,然后与服务器端进行通讯,音频和视频数据采用XMPP的扩展协议Jingle进行传输.平台在农产品安全生产中进行了试用,农业生产远程监测和专家咨询诊断在同一平台完成,保证了农作物生产的产量和品质.

  11. 基于医疗信息整合的超声科工作运行平台的构建与应用%Construction and application of the platform based on integrating the healthcare enterprise in ultrasonography department

    Institute of Scientific and Technical Information of China (English)

    谭易芬; 朱向明; 赵峰; 赵富江; 江峰; 李国杰; 刘表虎; 张青陵

    2012-01-01

    To realize the transmission and exchange of information among ultrasound information system (UIS), hospital information system (HIS) and PACS, and to build the platform of ultrasound department based on the three-lever structure: The client, the middle service layer and the serving end. Methods The design of the workflow was according to the integrating the healthcare enterprise (1HE) workflow patterns, information interaction and sharing was a-chieved using extensible markup language (XML) technology. The collection, transmission, storage of image information were followed by Digital Imaging and Communications in Medicine 3. 0 (DICOM 3. 0) standards, and communication among the models was followed by Health Level 7 (HL7) standards. Results The platform could achieve information exchange a-mong UIS, HIS and PACS and reduce the time in examination appointment, waiting in line and sending report. Further more it could optimize and standardize the workflow of ultrasonic medical department. Conclusion This platform is worthy for popularization and application.%目的 实现超声影像信息系统(UIS),医院信息系统(HIS)、PACS之间的信息传递与交互,构建客户端-中间服务层-服务端的3层架构的超声医学科工作运行平台.方法 参照医疗信息整合(IHE)工作流模式设计工作流程,采用XML技术实现信息交互和共享,遵循DICOM 3.0标准完成影像信息的采集、传输、存储,遵循HL7标准完成模型之间的通讯.结果 该平台可实现检查预约、排队叫号、结构化报告书写及发布等功能,并与Full PACS、EMR进行信息交互,缩短检查预约、排队等候和发送报告的时间,进一步优化和规范了超声科工作流程.结论 该平台具有较高的推广应用价值.

  12. Patent Platform, Innovative Integration and the Principle of Core Competence Formation%企业专利平台、创新整合与核心能力形成机理

    Institute of Scientific and Technical Information of China (English)

    朱国军; 杨晨

    2012-01-01

    The paper researches the enterprise patent platform based on the theoretical research framework of school of capacity and the practices of high-tech enterprise (the changhong group, for example). From the aspect of value chain, this paper proposes the nature and construction of enterprise patent platform, and the innovative integration from three level of innovation strategic, innovation organize and innovation technology. The paper promotes to formate core competence of enviroment element, market element, orgnizaiton element, and technology element. In the process, enterprise can combinate the cost leadership and differentiation strategy, gain sustainable competitive advantages. The paper provides new perspective for the formation mechanism of core competence of high-tech enterprise, gives a breakthrough in the patent platform and some inspiration in the core competence training and industrial upgrading.%本文基于能力学派的理论研究框架,结合部分高新技术企业发展实践,开展相关研究.从价值链视角,提出了高新技术企业专利平台内涵、构成及发展层次;指出基于企业专利平台,从战略、组织、技术三个层次开展创新整合,能够推动企业核心能力的环境元、变革元、管理元、技术元的形成与不断升级.在这一过程中,能够实现成本领先与差异化战略的有机结合,从而获得持久竞争优势.本研究成果对高新技术企业核心能力形成机理研究提供了新的研究视角,相关研究结论对我国高新技术企业以专利平台为突破口,制定核心能力培育策略、实现产业升级提供了重要理论启发.

  13. 三峡库区综合信息空间集成平台框架设计与实现%Design and Application of the Three Gorges Comprehensive Information Spatial Integration Platform Framework

    Institute of Scientific and Technical Information of China (English)

    郑丽娜; 邱儒琼; 赵薇; 何保国; 李兵

    2011-01-01

    在举世瞩目的三峡工程建设和百万移民的浩大工程即将结束之际,三峡工程建设的重点必然转移到库区建设和管理维护上来.库区建设的成败维系三峡工程的成败,维系库区安全和经济社会协调发展.从分析三峡库区信息资源现状情况入手,从体制、标准、空间技术手段等多层次地对三峡库区综合信息空间集成平台项目的集成框架进行了设计和实现.%When the world-renowned Three Gorges Project and millions of immigrants project draws to the end, the focus of the Three Gorges Project reservoir area must transfer to the construction and management of maintenance up. The success of the Three Gorges Reservoir Area construction relates to the Three Gorges project and to the safety and economic & social development in reservoir. By analyzing the situation of the Three Gorges Reservoir Area Information Resources to start, from the structure, standards, space technologies and other means of multi-level integrated information space of the Three Gorges reservoir area integration platform integrated framework for project design and implementation.

  14. Virtual health platform for medical tourism purposes.

    Science.gov (United States)

    Martinez, Debora; Ferriol, Pedro; Tous, Xisco; Cabrer, Miguel; Prats, Mercedes

    2008-01-01

    This paper introduces an overview of the Virtual Health Platform (VHP), an alternative approach to create a functional PHR system in a medical tourism environment. The proposed platform has been designed in order to be integrated with EHR infrastructures and in this way it expects to be useful and more advantageous to the patient or tourist. Use cases of the VHP and its potential benefits summarize the analysis. PMID:18560088

  15. Biochemical synthesis with stable isotopes

    International Nuclear Information System (INIS)

    Descriptions of the biochemical synthesis of glucose-13C6 from Agmenellum quadruplication; the biochemical labelling of [13C, 15N] Chlorella and [13C] E. coli, [15N] E. coli, and the production of lactic-13C3 acid utilizing Lactobacillus casei are discussed

  16. NASA's Integrated Instrument Simulator Suite for Atmospheric Remote Sensing from Spaceborne Platforms (ISSARS) and Its Role for the ACE and GPM Missions

    Science.gov (United States)

    Tanelli, Simone; Tao, Wei-Kuo; Hostetler, Chris; Kuo, Kwo-Sen; Matsui, Toshihisa; Jacob, Joseph C.; Niamsuwam, Noppasin; Johnson, Michael P.; Hair, John; Butler, Carolyn; Sy, Ousmane; Clune, Thomas; Diner, David J.; Durden, Stephen L.; Stephens, Graeme L.; Ackermann, Andy; Bowman, Kevin; Davis, Anthony B.; Fridlind, Ann; Kalashnikova, Olga V.; Kumar, Sujay; Liao, Liang; Martonchik, John V.; Turk, Joe

    2011-01-01

    Forward simulation is an indispensable tool for evaluation of precipitation retrieval algorithms as well as for studying snow/ice microphysics and their radiative properties. The main challenge of the implementation arises due to the size of the problem domain. To overcome this hurdle, assumptions need to be made to simplify compiles cloud microphysics. It is important that these assumptions are applied consistently throughout the simulation process. ISSARS addresses this issue by providing a computationally efficient and modular framework that can integrate currently existing models and is also capable of expanding for future development. ISSARS is designed to accommodate the simulation needs of the Aerosol/Clouds/Ecosystems (ACE) mission and the Global Precipitation Measurement (GPM) mission: radars, microwave radiometers, and optical instruments such as lidars and polarimeter. ISSARS's computation is performed in three stages: input reconditioning (IRM), electromagnetic properties (scattering/emission/absorption) calculation (SEAM), and instrument simulation (ISM). The computation is implemented as a web service while its configuration can be accessed through a web-based interface.

  17. The Implementation of Integrating e-Procurment, e-Contracting and e-Invoice Platforms for the B2B E-Market Place Web-Based System

    Directory of Open Access Journals (Sweden)

    Hsien-Yu Lee, Nai-Jian Wang

    2013-08-01

    Full Text Available —Corporations encounter several challenges when they adopt global logistic system in their producing and selling model. One of the most common concerns is how to efficiently share information among members in supply chain. The key solution for this problem is to ensure the accuracy of the purchasing, trading and supply data and to be able to integrate them.Nowadays, business competition has became more globally and been reaching its climax. The development of information technology and management techniques is also in a tremendous pace. Under the circumstances, business are provided as many opportunities as they have never seen before, but at the same time, they also face unprecedented challenges. In order to be more competitive, corporations must not only be able to coordinate with upstream providers, but also have to adequately allocate their internal resources.In the development of B2B market, Supply Chain Management (SCM, Enterprise Resource Planning (ERP and E-Commerce have been hot topics for a long time. However, there are some issues de

  18. Permeability-controlled optical modulator with Tri-gate metamaterial: control of permeability on InP-based photonic integration platform.

    Science.gov (United States)

    Amemiya, Tomohiro; Ishikawa, Atsushi; Kanazawa, Toru; Kang, JoonHyung; Nishiyama, Nobuhiko; Miyamoto, Yasuyuki; Tanaka, Takuo; Arai, Shigehisa

    2015-01-01

    Metamaterials are artificially structured materials that can produce innovative optical functionalities such as negative refractive index, invisibility cloaking, and super-resolution imaging. Combining metamaterials with semiconductors enables us to develop novel optoelectronic devices based on the new concept of operation. Here we report the first experimental demonstration of a permeability-controlled waveguide optical modulator consisting of an InGaAsP/InP Mach-Zehnder interferometer with 'tri-gate' metamaterial attached on its arms. The tri-gate metamaterial consists of metal resonator arrays and triple-gate field effect elements. It changes its permeability with a change in the controlling gate voltage, thereby changing the refractive index of the interferometer arm to switch the modulator with an extinction ratio of 6.9 dB at a wavelength of 1.55 μm. The result shows the feasibility of InP-based photonic integrated devices that can produce new functions by controlling their permeability as well as their permittivity. PMID:25797041

  19. mlearn: Designing a Platform for Mobile Learning

    OpenAIRE

    Samaka, Mohammed; Impagliazzo, John

    2013-01-01

    This chapter presents the findings of the first phase of a four-phase research study that involves the design and development of an integrated architecture for a mobile learning platform. During this phase, a high-level architecture was designed for a mobile learning platform called mLearn. The architecture of the mLearn platform allows XML multimedia content delivery over a HTTP protocol. It also uses J2ME on the client side in support of computer-aided learning approaches used in mobile lea...

  20. Fluidics platform and method for sample preparation

    Energy Technology Data Exchange (ETDEWEB)

    Benner, Henry W.; Dzenitis, John M.

    2016-06-21

    Provided herein are fluidics platforms and related methods for performing integrated sample collection and solid-phase extraction of a target component of the sample all in one tube. The fluidics platform comprises a pump, particles for solid-phase extraction and a particle-holding means. The method comprises contacting the sample with one or more reagents in a pump, coupling a particle-holding means to the pump and expelling the waste out of the pump while the particle-holding means retains the particles inside the pump. The fluidics platform and methods herein described allow solid-phase extraction without pipetting and centrifugation.