WorldWideScience

Sample records for biochemical network models

  1. Modeling stochasticity in biochemical reaction networks

    Science.gov (United States)

    Constantino, P. H.; Vlysidis, M.; Smadbeck, P.; Kaznessis, Y. N.

    2016-03-01

    Small biomolecular systems are inherently stochastic. Indeed, fluctuations of molecular species are substantial in living organisms and may result in significant variation in cellular phenotypes. The chemical master equation (CME) is the most detailed mathematical model that can describe stochastic behaviors. However, because of its complexity the CME has been solved for only few, very small reaction networks. As a result, the contribution of CME-based approaches to biology has been very limited. In this review we discuss the approach of solving CME by a set of differential equations of probability moments, called moment equations. We present different approaches to produce and to solve these equations, emphasizing the use of factorial moments and the zero information entropy closure scheme. We also provide information on the stability analysis of stochastic systems. Finally, we speculate on the utility of CME-based modeling formalisms, especially in the context of synthetic biology efforts.

  2. Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices

    DEFF Research Database (Denmark)

    Schmidt, Karsten; Carlsen, Morten; Nielsen, Jens Bredal;

    1997-01-01

    has been implemented that describes label distribution in primary carbon metabolism, i.e., in a metabolic network including the Embden-Meyerhof-Parnas and pentose phosphate pathway, the tricarboxylic acid cycle, and selected anaplerotic reaction sequences. The model calculates the steady state label...

  3. A Geometric Method for Model Reduction of Biochemical Networks with Polynomial Rate Functions.

    Science.gov (United States)

    Samal, Satya Swarup; Grigoriev, Dima; Fröhlich, Holger; Weber, Andreas; Radulescu, Ovidiu

    2015-12-01

    Model reduction of biochemical networks relies on the knowledge of slow and fast variables. We provide a geometric method, based on the Newton polytope, to identify slow variables of a biochemical network with polynomial rate functions. The gist of the method is the notion of tropical equilibration that provides approximate descriptions of slow invariant manifolds. Compared to extant numerical algorithms such as the intrinsic low-dimensional manifold method, our approach is symbolic and utilizes orders of magnitude instead of precise values of the model parameters. Application of this method to a large collection of biochemical network models supports the idea that the number of dynamical variables in minimal models of cell physiology can be small, in spite of the large number of molecular regulatory actors.

  4. A structured approach for the engineering of biochemical network models, illustrated for signalling pathways

    NARCIS (Netherlands)

    Breitling, Rainer; Gilbert, David; Heiner, Monika; Orton, Richard

    2008-01-01

    Quantitative models of biochemical networks (signal transduction cascades, metabolic pathways, gene regulatory circuits) are a central component of modern systems biology. Building and managing these complex models is a major challenge that can benefit from the application of formal methods adopted

  5. CADLIVE toolbox for MATLAB: automatic dynamic modeling of biochemical networks with comprehensive system analysis.

    Science.gov (United States)

    Inoue, Kentaro; Maeda, Kazuhiro; Miyabe, Takaaki; Matsuoka, Yu; Kurata, Hiroyuki

    2014-09-01

    Mathematical modeling has become a standard technique to understand the dynamics of complex biochemical systems. To promote the modeling, we had developed the CADLIVE dynamic simulator that automatically converted a biochemical map into its associated mathematical model, simulated its dynamic behaviors and analyzed its robustness. To enhance the feasibility by CADLIVE and extend its functions, we propose the CADLIVE toolbox available for MATLAB, which implements not only the existing functions of the CADLIVE dynamic simulator, but also the latest tools including global parameter search methods with robustness analysis. The seamless, bottom-up processes consisting of biochemical network construction, automatic construction of its dynamic model, simulation, optimization, and S-system analysis greatly facilitate dynamic modeling, contributing to the research of systems biology and synthetic biology. This application can be freely downloaded from http://www.cadlive.jp/CADLIVE_MATLAB/ together with an instruction.

  6. Modelling biochemical networks with intrinsic time delays: a hybrid semi-parametric approach

    Directory of Open Access Journals (Sweden)

    Oliveira Rui

    2010-09-01

    Full Text Available Abstract Background This paper presents a method for modelling dynamical biochemical networks with intrinsic time delays. Since the fundamental mechanisms leading to such delays are many times unknown, non conventional modelling approaches become necessary. Herein, a hybrid semi-parametric identification methodology is proposed in which discrete time series are incorporated into fundamental material balance models. This integration results in hybrid delay differential equations which can be applied to identify unknown cellular dynamics. Results The proposed hybrid modelling methodology was evaluated using two case studies. The first of these deals with dynamic modelling of transcriptional factor A in mammalian cells. The protein transport from the cytosol to the nucleus introduced a delay that was accounted for by discrete time series formulation. The second case study focused on a simple network with distributed time delays that demonstrated that the discrete time delay formalism has broad applicability to both discrete and distributed delay problems. Conclusions Significantly better prediction qualities of the novel hybrid model were obtained when compared to dynamical structures without time delays, being the more distinctive the more significant the underlying system delay is. The identification of the system delays by studies of different discrete modelling delays was enabled by the proposed structure. Further, it was shown that the hybrid discrete delay methodology is not limited to discrete delay systems. The proposed method is a powerful tool to identify time delays in ill-defined biochemical networks.

  7. Scalable rule-based modelling of allosteric proteins and biochemical networks.

    Directory of Open Access Journals (Sweden)

    Julien F Ollivier

    Full Text Available Much of the complexity of biochemical networks comes from the information-processing abilities of allosteric proteins, be they receptors, ion-channels, signalling molecules or transcription factors. An allosteric protein can be uniquely regulated by each combination of input molecules that it binds. This "regulatory complexity" causes a combinatorial increase in the number of parameters required to fit experimental data as the number of protein interactions increases. It therefore challenges the creation, updating, and re-use of biochemical models. Here, we propose a rule-based modelling framework that exploits the intrinsic modularity of protein structure to address regulatory complexity. Rather than treating proteins as "black boxes", we model their hierarchical structure and, as conformational changes, internal dynamics. By modelling the regulation of allosteric proteins through these conformational changes, we often decrease the number of parameters required to fit data, and so reduce over-fitting and improve the predictive power of a model. Our method is thermodynamically grounded, imposes detailed balance, and also includes molecular cross-talk and the background activity of enzymes. We use our Allosteric Network Compiler to examine how allostery can facilitate macromolecular assembly and how competitive ligands can change the observed cooperativity of an allosteric protein. We also develop a parsimonious model of G protein-coupled receptors that explains functional selectivity and can predict the rank order of potency of agonists acting through a receptor. Our methodology should provide a basis for scalable, modular and executable modelling of biochemical networks in systems and synthetic biology.

  8. Discriminating between rival biochemical network models: three approaches to optimal experiment design

    Directory of Open Access Journals (Sweden)

    August Elias

    2010-04-01

    Full Text Available Abstract Background The success of molecular systems biology hinges on the ability to use computational models to design predictive experiments, and ultimately unravel underlying biological mechanisms. A problem commonly encountered in the computational modelling of biological networks is that alternative, structurally different models of similar complexity fit a set of experimental data equally well. In this case, more than one molecular mechanism can explain available data. In order to rule out the incorrect mechanisms, one needs to invalidate incorrect models. At this point, new experiments maximizing the difference between the measured values of alternative models should be proposed and conducted. Such experiments should be optimally designed to produce data that are most likely to invalidate incorrect model structures. Results In this paper we develop methodologies for the optimal design of experiments with the aim of discriminating between different mathematical models of the same biological system. The first approach determines the 'best' initial condition that maximizes the L2 (energy distance between the outputs of the rival models. In the second approach, we maximize the L2-distance of the outputs by designing the optimal external stimulus (input profile of unit L2-norm. Our third method uses optimized structural changes (corresponding, for example, to parameter value changes reflecting gene knock-outs to achieve the same goal. The numerical implementation of each method is considered in an example, signal processing in starving Dictyostelium amœbæ. Conclusions Model-based design of experiments improves both the reliability and the efficiency of biochemical network model discrimination. This opens the way to model invalidation, which can be used to perfect our understanding of biochemical networks. Our general problem formulation together with the three proposed experiment design methods give the practitioner new tools for a systems

  9. An efficient algorithm for computing fixed length attractors based on bounded model checking in synchronous Boolean networks with biochemical applications.

    Science.gov (United States)

    Li, X Y; Yang, G W; Zheng, D S; Guo, W S; Hung, W N N

    2015-01-01

    Genetic regulatory networks are the key to understanding biochemical systems. One condition of the genetic regulatory network under different living environments can be modeled as a synchronous Boolean network. The attractors of these Boolean networks will help biologists to identify determinant and stable factors. Existing methods identify attractors based on a random initial state or the entire state simultaneously. They cannot identify the fixed length attractors directly. The complexity of including time increases exponentially with respect to the attractor number and length of attractors. This study used the bounded model checking to quickly locate fixed length attractors. Based on the SAT solver, we propose a new algorithm for efficiently computing the fixed length attractors, which is more suitable for large Boolean networks and numerous attractors' networks. After comparison using the tool BooleNet, empirical experiments involving biochemical systems demonstrated the feasibility and efficiency of our approach.

  10. Vector Encoding in Biochemical Networks

    Science.gov (United States)

    Potter, Garrett; Sun, Bo

    Encoding of environmental cues via biochemical signaling pathways is of vital importance in the transmission of information for cells in a network. The current literature assumes a single cell state is used to encode information, however, recent research suggests the optimal strategy utilizes a vector of cell states sampled at various time points. To elucidate the optimal sampling strategy for vector encoding, we take an information theoretic approach and determine the mutual information of the calcium signaling dynamics obtained from fibroblast cells perturbed with different concentrations of ATP. Specifically, we analyze the sampling strategies under the cases of fixed and non-fixed vector dimension as well as the efficiency of these strategies. Our results show that sampling with greater frequency is optimal in the case of non-fixed vector dimension but that, in general, a lower sampling frequency is best from both a fixed vector dimension and efficiency standpoint. Further, we find the use of a simple modified Ornstein-Uhlenbeck process as a model qualitatively captures many of our experimental results suggesting that sampling in biochemical networks is based on a few basic components.

  11. Minimal moment equations for stochastic models of biochemical reaction networks with partially finite state space

    Science.gov (United States)

    Ruess, Jakob

    2015-12-01

    Many stochastic models of biochemical reaction networks contain some chemical species for which the number of molecules that are present in the system can only be finite (for instance due to conservation laws), but also other species that can be present in arbitrarily large amounts. The prime example of such networks are models of gene expression, which typically contain a small and finite number of possible states for the promoter but an infinite number of possible states for the amount of mRNA and protein. One of the main approaches to analyze such models is through the use of equations for the time evolution of moments of the chemical species. Recently, a new approach based on conditional moments of the species with infinite state space given all the different possible states of the finite species has been proposed. It was argued that this approach allows one to capture more details about the full underlying probability distribution with a smaller number of equations. Here, I show that the result that less moments provide more information can only stem from an unnecessarily complicated description of the system in the classical formulation. The foundation of this argument will be the derivation of moment equations that describe the complete probability distribution over the finite state space but only low-order moments over the infinite state space. I will show that the number of equations that is needed is always less than what was previously claimed and always less than the number of conditional moment equations up to the same order. To support these arguments, a symbolic algorithm is provided that can be used to derive minimal systems of unconditional moment equations for models with partially finite state space.

  12. Dynamic analysis of biochemical network using complex network method

    Directory of Open Access Journals (Sweden)

    Wang Shuqiang

    2015-01-01

    Full Text Available In this study, the stochastic biochemical reaction model is proposed based on the law of mass action and complex network theory. The dynamics of biochemical reaction system is presented as a set of non-linear differential equations and analyzed at the molecular-scale. Given the initial state and the evolution rules of the biochemical reaction system, the system can achieve homeostasis. Compared with random graph, the biochemical reaction network has larger information capacity and is more efficient in information transmission. This is consistent with theory of evolution.

  13. Characterizing multistationarity regimes in biochemical reaction networks.

    Directory of Open Access Journals (Sweden)

    Irene Otero-Muras

    Full Text Available Switch like responses appear as common strategies in the regulation of cellular systems. Here we present a method to characterize bistable regimes in biochemical reaction networks that can be of use to both direct and reverse engineering of biological switches. In the design of a synthetic biological switch, it is important to study the capability for bistability of the underlying biochemical network structure. Chemical Reaction Network Theory (CRNT may help at this level to decide whether a given network has the capacity for multiple positive equilibria, based on their structural properties. However, in order to build a working switch, we also need to ensure that the bistability property is robust, by studying the conditions leading to the existence of two different steady states. In the reverse engineering of biological switches, knowledge collected about the bistable regimes of the underlying potential model structures can contribute at the model identification stage to a drastic reduction of the feasible region in the parameter space of search. In this work, we make use and extend previous results of the CRNT, aiming not only to discriminate whether a biochemical reaction network can exhibit multiple steady states, but also to determine the regions within the whole space of parameters capable of producing multistationarity. To that purpose we present and justify a condition on the parameters of biochemical networks for the appearance of multistationarity, and propose an efficient and reliable computational method to check its satisfaction through the parameter space.

  14. Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by Klebsiella Pneumoniae

    Science.gov (United States)

    Ye, Jianxiong; Feng, Enmin; Wang, Lei; Xiu, Zhilong; Sun, Yaqin

    Glycerol bioconversion to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae (K. pneumoniae) can be characterized by an intricate network of interactions among biochemical fluxes, metabolic compounds, key enzymes and genetic regulatory. To date, there still exist some uncertain factors in this complex network because of the limitation in bio-techniques, especially in measuring techniques for intracellular substances. In this paper, among these uncertain factors, we aim to infer the transport mechanisms of glycerol and 1,3-PD across the cell membrane, which have received intensive interest in recent years. On the basis of different inferences of the transport mechanisms, we reconstruct various metabolic networks correspondingly and subsequently develop their dynamical systems (S-systems). To determine the most reasonable metabolic network from all possible ones, we establish a quantitative definition of biological robustness and undertake parameter identification and robustness analysis for each system. Numerical results show that it is most possible that both glycerol and 1,3-PD pass the cell membrane by active transport and passive diffusion.

  15. An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks

    Directory of Open Access Journals (Sweden)

    Michael Gormley

    2011-01-01

    Full Text Available Identification of regulatory molecules in signaling pathways is critical for understanding cellular behavior. Given the complexity of the transcriptional gene network, the relationship between molecular expression and phenotype is difficult to determine using reductionist experimental methods. Computational models provide the means to characterize regulatory mechanisms and predict phenotype in the context of gene networks. Integrating gene expression data with phenotypic data in transcriptional network models enables systematic identification of critical molecules in a biological network. We developed an approach based on fuzzy logic to model cell budding in Saccharomyces cerevisiae using time series expression microarray data of the cell cycle. Cell budding is a phenotype of viable cells undergoing division. Predicted interactions between gene expression and phenotype reflected known biological relationships. Dynamic simulation analysis reproduced the behavior of the yeast cell cycle and accurately identified genes and interactions which are essential for cell viability.

  16. Model reduction and parameter estimation of non-linear dynamical biochemical reaction networks.

    Science.gov (United States)

    Sun, Xiaodian; Medvedovic, Mario

    2016-02-01

    Parameter estimation for high dimension complex dynamic system is a hot topic. However, the current statistical model and inference approach is known as a large p small n problem. How to reduce the dimension of the dynamic model and improve the accuracy of estimation is more important. To address this question, the authors take some known parameters and structure of system as priori knowledge and incorporate it into dynamic model. At the same time, they decompose the whole dynamic model into subset network modules, based on different modules, and then they apply different estimation approaches. This technique is called Rao-Blackwellised particle filters decomposition methods. To evaluate the performance of this method, the authors apply it to synthetic data generated from repressilator model and experimental data of the JAK-STAT pathway, but this method can be easily extended to large-scale cases.

  17. BNDB – The Biochemical Network Database

    Directory of Open Access Journals (Sweden)

    Kaufmann Michael

    2007-10-01

    Full Text Available Abstract Background Technological advances in high-throughput techniques and efficient data acquisition methods have resulted in a massive amount of life science data. The data is stored in numerous databases that have been established over the last decades and are essential resources for scientists nowadays. However, the diversity of the databases and the underlying data models make it difficult to combine this information for solving complex problems in systems biology. Currently, researchers typically have to browse several, often highly focused, databases to obtain the required information. Hence, there is a pressing need for more efficient systems for integrating, analyzing, and interpreting these data. The standardization and virtual consolidation of the databases is a major challenge resulting in a unified access to a variety of data sources. Description We present the Biochemical Network Database (BNDB, a powerful relational database platform, allowing a complete semantic integration of an extensive collection of external databases. BNDB is built upon a comprehensive and extensible object model called BioCore, which is powerful enough to model most known biochemical processes and at the same time easily extensible to be adapted to new biological concepts. Besides a web interface for the search and curation of the data, a Java-based viewer (BiNA provides a powerful platform-independent visualization and navigation of the data. BiNA uses sophisticated graph layout algorithms for an interactive visualization and navigation of BNDB. Conclusion BNDB allows a simple, unified access to a variety of external data sources. Its tight integration with the biochemical network library BN++ offers the possibility for import, integration, analysis, and visualization of the data. BNDB is freely accessible at http://www.bndb.org.

  18. Automatic Verification of Biochemical Network Using Model Checking Method%基于模型校核的生化网络自动辨别方法

    Institute of Scientific and Technical Information of China (English)

    Jinkyung Kim; Younghee Lee; Il Moon

    2008-01-01

    This study focuses on automatic searching and verifying methods for the reachability, transition logics and hierarchical structure in all possible paths of biological processes using model checking. The automatic search and verification for alternative paths within complex and large networks in biological process can provide a consid-erable amount of solutions, which is difficult to handle manually. Model checking is an automatic method for veri-fying if a circuit or a condition, expressed as a concurrent transition system, satisfies a set of properties expressed ina temporal logic, such as computational tree logic (CTL). This article represents that model checking is feasible in biochemical network verification and it shows certain advantages over simulation for querying and searching of special behavioral properties in biochemical processes.

  19. SABRE: A Tool for Stochastic Analysis of Biochemical Reaction Networks

    CERN Document Server

    Didier, Frederic; Mateescu, Maria; Wolf, Verena

    2010-01-01

    The importance of stochasticity within biological systems has been shown repeatedly during the last years and has raised the need for efficient stochastic tools. We present SABRE, a tool for stochastic analysis of biochemical reaction networks. SABRE implements fast adaptive uniformization (FAU), a direct numerical approximation algorithm for computing transient solutions of biochemical reaction networks. Biochemical reactions networks represent biological systems studied at a molecular level and these reactions can be modeled as transitions of a Markov chain. SABRE accepts as input the formalism of guarded commands, which it interprets either as continuous-time or as discrete-time Markov chains. Besides operating in a stochastic mode, SABRE may also perform a deterministic analysis by directly computing a mean-field approximation of the system under study. We illustrate the different functionalities of SABRE by means of biological case studies.

  20. Modeling the Differences in Biochemical Capabilities of Pseudomonas Species by Flux Balance Analysis: How Good Are Genome-Scale Metabolic Networks at Predicting the Differences?

    Directory of Open Access Journals (Sweden)

    Parizad Babaei

    2014-01-01

    Full Text Available To date, several genome-scale metabolic networks have been reconstructed. These models cover a wide range of organisms, from bacteria to human. Such models have provided us with a framework for systematic analysis of metabolism. However, little effort has been put towards comparing biochemical capabilities of closely related species using their metabolic models. The accuracy of a model is highly dependent on the reconstruction process, as some errors may be included in the model during reconstruction. In this study, we investigated the ability of three Pseudomonas metabolic models to predict the biochemical differences, namely, iMO1086, iJP962, and iSB1139, which are related to P. aeruginosa PAO1, P. putida KT2440, and P. fluorescens SBW25, respectively. We did a comprehensive literature search for previous works containing biochemically distinguishable traits over these species. Amongst more than 1700 articles, we chose a subset of them which included experimental results suitable for in silico simulation. By simulating the conditions provided in the actual biological experiment, we performed case-dependent tests to compare the in silico results to the biological ones. We found out that iMO1086 and iJP962 were able to predict the experimental data and were much more accurate than iSB1139.

  1. SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks

    DEFF Research Database (Denmark)

    Draeger, Andreas; Zielinski, Daniel C.; Keller, Roland;

    2015-01-01

    Background: The size and complexity of published biochemical network reconstructions are steadily increasing, expanding the potential scale of derived computational models. However, the construction of large biochemical network models is a laborious and error-prone task. Automated methods have...... during kinetic model construction would thus benefit from automated methods for rate law assignment. Results: We present a high-throughput algorithm to automatically suggest and create suitable rate laws based upon reaction type according to several criteria. The criteria for choices made...

  2. SIMULATING BIOCHEMICAL SIGNALING NETWORKS IN COMPLEX MOVING GEOMETRIES.

    Science.gov (United States)

    Strychalski, Wanda; Adalsteinsson, David; Elston, Timothy C

    2010-01-01

    Signaling networks regulate cellular responses to environmental stimuli through cascades of protein interactions. External signals can trigger cells to polarize and move in a specific direction. During migration, spatially localized activity of proteins is maintained. To investigate the effects of morphological changes on intracellular signaling, we developed a numerical scheme consisting of a cut cell finite volume spatial discretization coupled with level set methods to simulate the resulting advection-reaction-diffusion system. We then apply the method to several biochemical reaction networks in changing geometries. We found that a Turing instability can develop exclusively by cell deformations that maintain constant area. For a Turing system with a geometry-dependent single or double peak solution, simulations in a dynamically changing geometry suggest that a single peak solution is the only stable one, independent of the oscillation frequency. The method is also applied to a model of a signaling network in a migrating fibroblast. PMID:24086102

  3. Turing-Hopf instability in biochemical reaction networks arising from pairs of subnetworks.

    Science.gov (United States)

    Mincheva, Maya; Roussel, Marc R

    2012-11-01

    Network conditions for Turing instability in biochemical systems with two biochemical species are well known and involve autocatalysis or self-activation. On the other hand general network conditions for potential Turing instabilities in large biochemical reaction networks are not well developed. A biochemical reaction network with any number of species where only one species moves is represented by a simple digraph and is modeled by a reaction-diffusion system with non-mass action kinetics. A graph-theoretic condition for potential Turing-Hopf instability that arises when a spatially homogeneous equilibrium loses its stability via a single pair of complex eigenvalues is obtained. This novel graph-theoretic condition is closely related to the negative cycle condition for oscillations in ordinary differential equation models and its generalizations, and requires the existence of a pair of subnetworks, each containing an even number of positive cycles. The technique is illustrated with a double-cycle Goodwin type model. PMID:22698892

  4. The alterations in biochemical signaling of hippocampal network activity in the autism brain The alterations in biochemical signaling of hippocampal network activity in the autism brain The alterations in biochemical signaling of hippocampal network activity in the autism brain

    Institute of Scientific and Technical Information of China (English)

    田允; 黄继云; 王锐; 陶蓉蓉; 卢应梅; 廖美华; 陆楠楠; 李静; 芦博; 韩峰

    2012-01-01

    Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and communication. However, the role of synaptic dysfunction during development of autism remains unclear. In the present study, we address the alterations of biochemical signaling in hippocampal network following induction of the autism in experimental animals. Here, the an- imal disease model and DNA array being used to investigate the differences in transcriptome or- ganization between autistic and normal brain by gene co--expression network analysis.

  5. Insights into the organization of biochemical regulatory networks using graph theory analyses.

    Science.gov (United States)

    Ma'ayan, Avi

    2009-02-27

    Graph theory has been a valuable mathematical modeling tool to gain insights into the topological organization of biochemical networks. There are two types of insights that may be obtained by graph theory analyses. The first provides an overview of the global organization of biochemical networks; the second uses prior knowledge to place results from multivariate experiments, such as microarray data sets, in the context of known pathways and networks to infer regulation. Using graph analyses, biochemical networks are found to be scale-free and small-world, indicating that these networks contain hubs, which are proteins that interact with many other molecules. These hubs may interact with many different types of proteins at the same time and location or at different times and locations, resulting in diverse biological responses. Groups of components in networks are organized in recurring patterns termed network motifs such as feedback and feed-forward loops. Graph analysis revealed that negative feedback loops are less common and are present mostly in proximity to the membrane, whereas positive feedback loops are highly nested in an architecture that promotes dynamical stability. Cell signaling networks have multiple pathways from some input receptors and few from others. Such topology is reminiscent of a classification system. Signaling networks display a bow-tie structure indicative of funneling information from extracellular signals and then dispatching information from a few specific central intracellular signaling nexuses. These insights show that graph theory is a valuable tool for gaining an understanding of global regulatory features of biochemical networks. PMID:18940806

  6. Insights into the organization of biochemical regulatory networks using graph theory analyses.

    Science.gov (United States)

    Ma'ayan, Avi

    2009-02-27

    Graph theory has been a valuable mathematical modeling tool to gain insights into the topological organization of biochemical networks. There are two types of insights that may be obtained by graph theory analyses. The first provides an overview of the global organization of biochemical networks; the second uses prior knowledge to place results from multivariate experiments, such as microarray data sets, in the context of known pathways and networks to infer regulation. Using graph analyses, biochemical networks are found to be scale-free and small-world, indicating that these networks contain hubs, which are proteins that interact with many other molecules. These hubs may interact with many different types of proteins at the same time and location or at different times and locations, resulting in diverse biological responses. Groups of components in networks are organized in recurring patterns termed network motifs such as feedback and feed-forward loops. Graph analysis revealed that negative feedback loops are less common and are present mostly in proximity to the membrane, whereas positive feedback loops are highly nested in an architecture that promotes dynamical stability. Cell signaling networks have multiple pathways from some input receptors and few from others. Such topology is reminiscent of a classification system. Signaling networks display a bow-tie structure indicative of funneling information from extracellular signals and then dispatching information from a few specific central intracellular signaling nexuses. These insights show that graph theory is a valuable tool for gaining an understanding of global regulatory features of biochemical networks.

  7. An effective method for computing the noise in biochemical networks

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; He, Miao; Zhou, Tianshou

    2013-02-01

    We present a simple yet effective method, which is based on power series expansion, for computing exact binomial moments that can be in turn used to compute steady-state probability distributions as well as the noise in linear or nonlinear biochemical reaction networks. When the method is applied to representative reaction networks such as the ON-OFF models of gene expression, gene models of promoter progression, gene auto-regulatory models, and common signaling motifs, the exact formulae for computing the intensities of noise in the species of interest or steady-state distributions are analytically given. Interestingly, we find that positive (negative) feedback does not enlarge (reduce) noise as claimed in previous works but has a counter-intuitive effect and that the multi-OFF (or ON) mechanism always attenuates the noise in contrast to the common ON-OFF mechanism and can modulate the noise to the lowest level independently of the mRNA mean. Except for its power in deriving analytical expressions for distributions and noise, our method is programmable and has apparent advantages in reducing computational cost.

  8. Unveiling the hidden structure of complex stochastic biochemical networks

    Science.gov (United States)

    Valleriani, Angelo; Li, Xin; Kolomeisky, Anatoly B.

    2014-02-01

    Complex Markov models are widely used and powerful predictive tools to analyze stochastic biochemical processes. However, when the network of states is unknown, it is necessary to extract information from the data to partially build the network and estimate the values of the rates. The short-time behavior of the first-passage time distributions between two states in linear chains has been shown recently to behave as a power of time with an exponent equal to the number of intermediate states. For a general Markov model we derive the complete Taylor expansion of the first-passage time distribution between two arbitrary states. By combining algebraic methods and graph theory approaches it is shown that the first term of the Taylor expansion is determined by the shortest path from the initial state to the final state. When this path is unique, we prove that the coefficient of the first term can be written in terms of the product of the transition rates along the path. It is argued that the application of our results to first-return times may be used to estimate the dependence of rates on external parameters in experimentally measured time distributions.

  9. Mean field interaction in biochemical reaction networks

    KAUST Repository

    Tembine, Hamidou

    2011-09-01

    In this paper we establish a relationship between chemical dynamics and mean field game dynamics. We show that chemical reaction networks can be studied using noisy mean field limits. We provide deterministic, noisy and switching mean field limits and illustrate them with numerical examples. © 2011 IEEE.

  10. Trade-Offs in Delayed Information Transmission in Biochemical Networks

    Science.gov (United States)

    Mancini, F.; Marsili, M.; Walczak, A. M.

    2016-03-01

    In order to transmit biochemical signals, biological regulatory systems dissipate energy with concomitant entropy production. Additionally, signaling often takes place in challenging environmental conditions. In a simple model regulatory circuit given by an input and a delayed output, we explore the trade-offs between information transmission and the system's energetic efficiency. We determine the maximally informative network, given a fixed amount of entropy production and a delayed response, exploring both the case with and without feedback. We find that feedback allows the circuit to overcome energy constraints and transmit close to the maximum available information even in the dissipationless limit. Negative feedback loops, characteristic of shock responses, are optimal at high dissipation. Close to equilibrium positive feedback loops, known for their stability, become more informative. Asking how the signaling network should be constructed to best function in the worst possible environment, rather than an optimally tuned one or in steady state, we discover that at large dissipation the same universal motif is optimal in all of these conditions.

  11. Transient amplification limits noise suppression in biochemical networks

    Science.gov (United States)

    Dixon, John; Lindemann, Anika; McCoy, Jonathan H.

    2016-01-01

    Cell physiology is orchestrated, on a molecular level, through complex networks of biochemical reactions. The propagation of random fluctuations through these networks can significantly impact cell behavior, raising challenging questions about how network design shapes the cell's ability to suppress or exploit these fluctuations. Here, drawing on insights from statistical physics, fluid dynamics, and systems biology, we explore how transient amplification phenomena arising from network connectivity naturally limit a biochemical system's ability to suppress small fluctuations around steady-state behaviors. We find that even a simple system consisting of two variables linked by a single interaction is capable of amplifying small fluctuations orders of magnitude beyond the levels predicted by linear stability theory. We also find that adding additional interactions can promote further amplification, even when these interactions implement classic design strategies known to suppress fluctuations. These results establish that transient amplification is an essential factor determining baseline noise levels in stable intracellular networks. Significantly, our analysis is not bound to specific systems or interaction mechanisms: we find that noise amplification is an emergent phenomenon found near steady states in any network containing sufficiently strong interactions, regardless of its form or function.

  12. Signal detection, modularity and the correlation between extrinsic and intrinsic noise in biochemical networks

    OpenAIRE

    Tanase-Nicola, Sorin; Warren, Patrick B.; Wolde, Pieter Rein ten

    2005-01-01

    Understanding cell function requires an accurate description of how noise is transmitted through biochemical networks. We present an analytical result for the power spectrum of the output signal of a biochemical network that takes into account the correlations between the noise in the input signal (the extrinsic noise) and the noise in the reactions that constitute the network (the intrinsic noise). These correlations arise from the fact that the reactions by which biochemical signals are det...

  13. Coarse-graining stochastic biochemical networks: adiabaticity and fast simulations

    Energy Technology Data Exchange (ETDEWEB)

    Nemenman, Ilya [Los Alamos National Laboratory; Sinitsyn, Nikolai [Los Alamos National Laboratory; Hengartner, Nick [Los Alamos National Laboratory

    2008-01-01

    We propose a universal approach for analysis and fast simulations of stiff stochastic biochemical kinetics networks, which rests on elimination of fast chemical species without a loss of information about mesoscoplc, non-Poissonian fluctuations of the slow ones. Our approach, which is similar to the Born-Oppenhelmer approximation in quantum mechanics, follows from the stochastic path Integral representation of the cumulant generating function of reaction events. In applications with a small number of chemIcal reactions, It produces analytical expressions for cumulants of chemical fluxes between the slow variables. This allows for a low-dimensional, Interpretable representation and can be used for coarse-grained numerical simulation schemes with a small computational complexity and yet high accuracy. As an example, we derive the coarse-grained description for a chain of biochemical reactions, and show that the coarse-grained and the microscopic simulations are in an agreement, but the coarse-gralned simulations are three orders of magnitude faster.

  14. Model-Based Design of Biochemical Microreactors.

    Science.gov (United States)

    Elbinger, Tobias; Gahn, Markus; Neuss-Radu, Maria; Hante, Falk M; Voll, Lars M; Leugering, Günter; Knabner, Peter

    2016-01-01

    Mathematical modeling of biochemical pathways is an important resource in Synthetic Biology, as the predictive power of simulating synthetic pathways represents an important step in the design of synthetic metabolons. In this paper, we are concerned with the mathematical modeling, simulation, and optimization of metabolic processes in biochemical microreactors able to carry out enzymatic reactions and to exchange metabolites with their surrounding medium. The results of the reported modeling approach are incorporated in the design of the first microreactor prototypes that are under construction. These microreactors consist of compartments separated by membranes carrying specific transporters for the input of substrates and export of products. Inside the compartments of the reactor multienzyme complexes assembled on nano-beads by peptide adapters are used to carry out metabolic reactions. The spatially resolved mathematical model describing the ongoing processes consists of a system of diffusion equations together with boundary and initial conditions. The boundary conditions model the exchange of metabolites with the neighboring compartments and the reactions at the surface of the nano-beads carrying the multienzyme complexes. Efficient and accurate approaches for numerical simulation of the mathematical model and for optimal design of the microreactor are developed. As a proof-of-concept scenario, a synthetic pathway for the conversion of sucrose to glucose-6-phosphate (G6P) was chosen. In this context, the mathematical model is employed to compute the spatio-temporal distributions of the metabolite concentrations, as well as application relevant quantities like the outflow rate of G6P. These computations are performed for different scenarios, where the number of beads as well as their loading capacity are varied. The computed metabolite distributions show spatial patterns, which differ for different experimental arrangements. Furthermore, the total output of G6P

  15. Collaborative networks: Reference modeling

    NARCIS (Netherlands)

    L.M. Camarinha-Matos; H. Afsarmanesh

    2008-01-01

    Collaborative Networks: Reference Modeling works to establish a theoretical foundation for Collaborative Networks. Particular emphasis is put on modeling multiple facets of collaborative networks and establishing a comprehensive modeling framework that captures and structures diverse perspectives of

  16. Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties.

    Science.gov (United States)

    Tong, Xinming; Yang, Fan

    2014-02-01

    Hydrogels have been widely used as artificial cell niche to mimic extracellular matrix with tunable properties. However, changing biochemical cues in hydrogels developed-to-date would often induce simultaneous changes in mechanical properties, which do not support mechanistic studies on stem cell-niche interactions. Here we report the development of a PEG-based interpenetrating network (IPN), which is composed of two polymer networks that can independently and simultaneously crosslink to form hydrogels in a cell-friendly manner. The resulting IPN hydrogel allows independently tunable biochemical and mechanical properties, as well as stable and more homogeneous presentation of biochemical ligands in 3D than currently available methods. We demonstrate the potential of our IPN platform for elucidating stem cell-niche interactions by modulating osteogenic differentiation of human adipose-derived stem cells. The versatility of such IPN hydrogels is further demonstrated using three distinct and widely used polymers to form the mechanical network while keeping the biochemical network constant.

  17. Efficient Characterization of Parametric Uncertainty of Complex (Biochemical Networks.

    Directory of Open Access Journals (Sweden)

    Claudia Schillings

    2015-08-01

    Full Text Available Parametric uncertainty is a particularly challenging and relevant aspect of systems analysis in domains such as systems biology where, both for inference and for assessing prediction uncertainties, it is essential to characterize the system behavior globally in the parameter space. However, current methods based on local approximations or on Monte-Carlo sampling cope only insufficiently with high-dimensional parameter spaces associated with complex network models. Here, we propose an alternative deterministic methodology that relies on sparse polynomial approximations. We propose a deterministic computational interpolation scheme which identifies most significant expansion coefficients adaptively. We present its performance in kinetic model equations from computational systems biology with several hundred parameters and state variables, leading to numerical approximations of the parametric solution on the entire parameter space. The scheme is based on adaptive Smolyak interpolation of the parametric solution at judiciously and adaptively chosen points in parameter space. As Monte-Carlo sampling, it is "non-intrusive" and well-suited for massively parallel implementation, but affords higher convergence rates. This opens up new avenues for large-scale dynamic network analysis by enabling scaling for many applications, including parameter estimation, uncertainty quantification, and systems design.

  18. A moment-convergence method for stochastic analysis of biochemical reaction networks

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; Zhou, Tianshou

    2016-05-01

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  19. Simplifying biochemical models with intermediate species

    DEFF Research Database (Denmark)

    Feliu, Elisenda; Wiuf, Carsten

    2013-01-01

    canonical model that characterizes crucial dynamical properties, such as mono- and multistationarity and stability of steady states, of all models in the class. We show that if the core model does not have conservation laws, then the introduction of intermediates does not change the steady...

  20. Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs

    LENUS (Irish Health Repository)

    Casey, Fergal

    2011-08-22

    Abstract Background Gene and protein interactions are commonly represented as networks, with the genes or proteins comprising the nodes and the relationship between them as edges. Motifs, or small local configurations of edges and nodes that arise repeatedly, can be used to simplify the interpretation of networks. Results We examined triplet motifs in a network of quantitative epistatic genetic relationships, and found a non-random distribution of particular motif classes. Individual motif classes were found to be associated with different functional properties, suggestive of an underlying biological significance. These associations were apparent not only for motif classes, but for individual positions within the motifs. As expected, NNN (all negative) motifs were strongly associated with previously reported genetic (i.e. synthetic lethal) interactions, while PPP (all positive) motifs were associated with protein complexes. The two other motif classes (NNP: a positive interaction spanned by two negative interactions, and NPP: a negative spanned by two positives) showed very distinct functional associations, with physical interactions dominating for the former but alternative enrichments, typical of biochemical pathways, dominating for the latter. Conclusion We present a model showing how NNP motifs can be used to recognize supportive relationships between protein complexes, while NPP motifs often identify opposing or regulatory behaviour between a gene and an associated pathway. The ability to use motifs to point toward underlying biological organizational themes is likely to be increasingly important as more extensive epistasis mapping projects in higher organisms begin.

  1. A computational model for the identification of biochemical pathways in the krebs cycle.

    Science.gov (United States)

    Oliveira, Joseph S; Bailey, Colin G; Jones-Oliveira, Janet B; Dixon, David A; Gull, Dean W; Chandler, Mary L

    2003-01-01

    We have applied an algorithmic methodology which provably decomposes any complex network into a complete family of principal subcircuits to study the minimal circuits that describe the Krebs cycle. Every operational behavior that the network is capable of exhibiting can be represented by some combination of these principal subcircuits and this computational decomposition is linearly efficient. We have developed a computational model that can be applied to biochemical reaction systems which accurately renders pathways of such reactions via directed hypergraphs (Petri nets). We have applied the model to the citric acid cycle (Krebs cycle). The Krebs cycle, which oxidizes the acetyl group of acetyl CoA to CO(2) and reduces NAD and FAD to NADH and FADH(2), is a complex interacting set of nine subreaction networks. The Krebs cycle was selected because of its familiarity to the biological community and because it exhibits enough complexity to be interesting in order to introduce this novel analytic approach. This study validates the algorithmic methodology for the identification of significant biochemical signaling subcircuits, based solely upon the mathematical model and not upon prior biological knowledge. The utility of the algebraic-combinatorial model for identifying the complete set of biochemical subcircuits as a data set is demonstrated for this important metabolic process.

  2. ADVANCES ON BILINEAR MODELING OF BIOCHEMICAL BATCH PROCESSES

    OpenAIRE

    GONZÁLEZ MARTÍNEZ, JOSÉ MARÍA

    2015-01-01

    [EN] This thesis is aimed to study the implications of the statistical modeling approaches proposed for the bilinear modeling of batch processes, develop new techniques to overcome some of the problems that have not been yet solved and apply them to data of biochemical processes. The study, discussion and development of the new methods revolve around the four steps of the modeling cycle, from the alignment, preprocessing and calibration of batch data to the monitoring of batches trajectories....

  3. Modeling worldwide highway networks

    Science.gov (United States)

    Villas Boas, Paulino R.; Rodrigues, Francisco A.; da F. Costa, Luciano

    2009-12-01

    This Letter addresses the problem of modeling the highway systems of different countries by using complex networks formalism. More specifically, we compare two traditional geographical models with a modified geometrical network model where paths, rather than edges, are incorporated at each step between the origin and the destination vertices. Optimal configurations of parameters are obtained for each model and used for the comparison. The highway networks of Australia, Brazil, India, and Romania are considered and shown to be properly modeled by the modified geographical model.

  4. Brain Network Modelling

    DEFF Research Database (Denmark)

    Andersen, Kasper Winther

    Three main topics are presented in this thesis. The first and largest topic concerns network modelling of functional Magnetic Resonance Imaging (fMRI) and Diffusion Weighted Imaging (DWI). In particular nonparametric Bayesian methods are used to model brain networks derived from resting state f...... for their ability to reproduce node clustering and predict unseen data. Comparing the models on whole brain networks, BCD and IRM showed better reproducibility and predictability than IDM, suggesting that resting state networks exhibit community structure. This also points to the importance of using models, which...... allow for complex interactions between all pairs of clusters. In addition, it is demonstrated how the IRM can be used for segmenting brain structures into functionally coherent clusters. A new nonparametric Bayesian network model is presented. The model builds upon the IRM and can be used to infer...

  5. Modeling Epidemic Network Failures

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Fagertun, Anna Manolova

    2013-01-01

    This paper presents the implementation of a failure propagation model for transport networks when multiple failures occur resulting in an epidemic. We model the Susceptible Infected Disabled (SID) epidemic model and validate it by comparing it to analytical solutions. Furthermore, we evaluate...... the SID model’s behavior and impact on the network performance, as well as the severity of the infection spreading. The simulations are carried out in OPNET Modeler. The model provides an important input to epidemic connection recovery mechanisms, and can due to its flexibility and versatility be used...... to evaluate multiple epidemic scenarios in various network types....

  6. Biochemical correlates in an animal model of depression

    International Nuclear Information System (INIS)

    A valid animal model of depression was used to explore specific adrenergic receptor differences between rats exhibiting aberrant behavior and control groups. Preliminary experiments revealed a distinct upregulation of hippocampal beta-receptors (as compared to other brain regions) in those animals acquiring a response deficit as a result of exposure to inescapable footshock. Concurrent studies using standard receptor binding techniques showed no large changes in the density of alpha-adrenergic, serotonergic, or dopaminergic receptor densities. This led to the hypothesis that the hippocampal beta-receptor in responses deficient animals could be correlated with the behavioral changes seen after exposure to the aversive stimulus. Normalization of the behavior through the administration of antidepressants could be expected to reverse the biochemical changes if these are related to the mechanism of action of antidepressant drugs. This study makes three important points: (1) there is a relevant biochemical change in the hippocampus of response deficient rats which occurs in parallel to a well-defined behavior, (2) the biochemical and behavioral changes are normalized by antidepressant treatments exhibiting both serotonergic and adrenergic mechanisms of action, and (3) the mode of action of antidepressants in this model is probably a combination of serotonergic and adrenergic influences modulating the hippocampal beta-receptor. These results are discussed in relation to anatomical and biochemical aspects of antidepressant action

  7. Artificial neural network modelling

    CERN Document Server

    Samarasinghe, Sandhya

    2016-01-01

    This book covers theoretical aspects as well as recent innovative applications of Artificial Neural networks (ANNs) in natural, environmental, biological, social, industrial and automated systems. It presents recent results of ANNs in modelling small, large and complex systems under three categories, namely, 1) Networks, Structure Optimisation, Robustness and Stochasticity 2) Advances in Modelling Biological and Environmental Systems and 3) Advances in Modelling Social and Economic Systems. The book aims at serving undergraduates, postgraduates and researchers in ANN computational modelling. .

  8. Hysteresis-driven structure formation in biochemical networks

    Science.gov (United States)

    Klein

    1998-09-21

    A mechanism of structure formation, based on hysteresis behaviour is presented. A bisubstrate kinetic system with substrate inhibition, discussed previously in the context of Turing structure formation, may show hysteresis behaviour, when embedded in a metabolic network: the system may possess multiple steady states and may be switched from one stable fixpoint to the other. When cells containing this type of system are diffusively coupled, under certain conditions patterns result, which, as is demonstrated, are not of the Turing type. The main difference to diffusion-driven (Turing) structures is the fact that the hysteresis-driven patterns emerge under diffusive conditions, under which both the homogeneous and the asymmetrical steady state is stable. The resulting special properties and biological implications are discussed.Copyright 1998 Academic Press Limited PMID:9778438

  9. Constrictor: Flux Balance Analysis Constraint Modification Provides Insight for Design of Biochemical Networks

    Science.gov (United States)

    Erickson, Keesha; Chatterjee, Anushree

    2014-03-01

    The use of in silico methods has become standard practice to correlate the structure of a biochemical network to the expression of a desired phenotype. Flux balance analysis (FBA) is one of the most prevalent techniques for modeling metabolism. FBA models have been successfully applied to obtain growth predictions, theoretical product yields from heterologous pathways, and genome engineering targets. We take inspiration from high-throughput recombineering techniques, which show that combinatorial exploration can reveal optimal mutants, and apply the advantages of computational techniques to analyze these combinations. We introduce Constrictor, an in silico tool for FBA that allows gene mutations to be analyzed in a combinatorial fashion, by applying simulated constraints accounting for regulation of gene expression. We apply this algorithm to study ethylene production in E. coli through the addition of the heterologous ethylene-forming enzyme from P. syringae. Targeting individual reactions as well as sets of reactions results in theoretical ethylene yields that are as much 65% greater than yields calculated using typical FBA. Constrictor is an adaptable technique that can be used to generate and analyze disparate populations of in silico mutants & select gene expression levels.

  10. Piecewise linear and Boolean models of chemical reaction networks.

    Science.gov (United States)

    Veliz-Cuba, Alan; Kumar, Ajit; Josić, Krešimir

    2014-12-01

    Models of biochemical networks are frequently complex and high-dimensional. Reduction methods that preserve important dynamical properties are therefore essential for their study. Interactions in biochemical networks are frequently modeled using Hill functions ([Formula: see text]). Reduced ODEs and Boolean approximations of such model networks have been studied extensively when the exponent [Formula: see text] is large. However, while the case of small constant [Formula: see text] appears in practice, it is not well understood. We provide a mathematical analysis of this limit and show that a reduction to a set of piecewise linear ODEs and Boolean networks can be mathematically justified. The piecewise linear systems have closed-form solutions that closely track those of the fully nonlinear model. The simpler, Boolean network can be used to study the qualitative behavior of the original system. We justify the reduction using geometric singular perturbation theory and compact convergence, and illustrate the results in network models of a toggle switch and an oscillator.

  11. Biochemical Models for S-Rnase-Based Self-Incompatibility

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hua Hua; Allison Fields; Teh-hui Kao

    2008-01-01

    S-RNase-based self-incompatibility (SI) is a genetically determined self/non-self-recognition process employed by many flowering plant species to prevent inbreeding and promote outcrosses.For the Plantaginaceae,Rosa-ceae and Solanaceae,it is now known that S-RNase and S-Iocu F-box(two multiple allelic genes at the S-locus)determine the female and male specificity,respectively,during SI interactions.However,how allelic products of these two genes interact inside pollen tubes to result in specific growth inhibition of self-pollen tubes remains to be investigated.Here,we review all the previously proposed biochemical models and discuss whether their predictions are consistent with all SI phenomena,including competitive jnteraction where SI breaks down in pollen that carries two different pollen 5-alleles.We also discuss these models in Iight of the recent findings of compartmentalization of S-RNases in both incompatible and compatible pollen tubes.Lastly,we summarize the results from our recent biochemical studies of PiSLF(Petunia inflata SLF)and S-RNase.and present a new model for the biochemical mechanism of SI in the Solanaceae.The tenet of this model is that a PiSLF preferentially interacts with its non-self S-RNases in the cytoplasm of a pollen tube to result in the assembly of an E3-like complex,which then mediates ubiquitination and degradation of non-self S-RNases through the ubiquitin-26S proteasome pathway.This model can explain all SI phenomena and,at the same time,has raised new questions for further study.

  12. Relationship between cellular response models and biochemical mechanisms

    International Nuclear Information System (INIS)

    In most cellular response experiments, survival reflects the kinetics of a variety of damage and repair processes. Unfortunately, biochemical studies of molecular repair deal with mechanisms which cannot be readily correlated with these kinetic observations. The difference in these approaches sometimes leads to confusion over terms such as potentially-lethal and sublethal damage. These terms were introduced with operation definitions, derived from kinetic studies of cell survival, but some researchers have since attempted to associate them with specific biochemical mechanisms. Consequently, the terms are often used in totally different ways be different investigators. The use of carefully constructed models originating either out of assumptions based on mechanisms, or on kinetics, can be used to design experiments to eliminate some alternative kinetic schemes. In turn, some mechanisms may also be eliminated, resulting in a reduction in the number of mechanisms which must be investigated biochemically. One must take advantage of a wide range of specialized radiation procedures in order to accomplish this. Examples of the use of such specialized experimental designs, which have led to a more detailed understanding of the kinetics of both algal and mammalian cell responses, are discussed

  13. A general method for modeling biochemical and biomedical response

    Science.gov (United States)

    Ortiz, Roberto; Lerd Ng, Jia; Hughes, Tyler; Abou Ghantous, Michel; Bouhali, Othmane; Arredouani, Abdelilah; Allen, Roland

    2012-10-01

    The impressive achievements of biomedical science have come mostly from experimental research with human subjects, animal models, and sophisticated laboratory techniques. Additionally, theoretical chemistry has been a major aid in designing new drugs. Here we introduce a method which is similar to others already well known in theoretical systems biology, but which specifically addresses biochemical changes as the human body responds to medical interventions. It is common in systems biology to use first-order differential equations to model the time evolution of various chemical concentrations, and we as physicists can make a significant impact through designing realistic models and then solving the resulting equations. Biomedical research is rapidly advancing, and the technique presented in this talk can be applied in arbitrarily large models containing tens, hundreds, or even thousands of interacting species, to determine what beneficial effects and side effects may result from pharmaceuticals or other medical interventions.

  14. Combining Flux Balance and Energy Balance Analysis for Large-Scale Metabolic Network: Biochemical Circuit Theory for Analysis of Large-Scale Metabolic Networks

    Science.gov (United States)

    Beard, Daniel A.; Liang, Shou-Dan; Qian, Hong; Biegel, Bryan (Technical Monitor)

    2001-01-01

    Predicting behavior of large-scale biochemical metabolic networks represents one of the greatest challenges of bioinformatics and computational biology. Approaches, such as flux balance analysis (FBA), that account for the known stoichiometry of the reaction network while avoiding implementation of detailed reaction kinetics are perhaps the most promising tools for the analysis of large complex networks. As a step towards building a complete theory of biochemical circuit analysis, we introduce energy balance analysis (EBA), which compliments the FBA approach by introducing fundamental constraints based on the first and second laws of thermodynamics. Fluxes obtained with EBA are thermodynamically feasible and provide valuable insight into the activation and suppression of biochemical pathways.

  15. The Chemical Master Equation Approach to Nonequilibrium Steady-State of Open Biochemical Systems: Linear Single-Molecule Enzyme Kinetics and Nonlinear Biochemical Reaction Networks

    Directory of Open Access Journals (Sweden)

    Lisa M. Bishop

    2010-09-01

    Full Text Available We develop the stochastic, chemical master equation as a unifying approach to the dynamics of biochemical reaction systems in a mesoscopic volume under a living environment. A living environment provides a continuous chemical energy input that sustains the reaction system in a nonequilibrium steady state with concentration fluctuations. We discuss the linear, unimolecular single-molecule enzyme kinetics, phosphorylation-dephosphorylation cycle (PdPC with bistability, and network exhibiting oscillations. Emphasis is paid to the comparison between the stochastic dynamics and the prediction based on the traditional approach based on the Law of Mass Action. We introduce the difference between nonlinear bistability and stochastic bistability, the latter has no deterministic counterpart. For systems with nonlinear bistability, there are three different time scales: (a individual biochemical reactions, (b nonlinear network dynamics approaching to attractors, and (c cellular evolution. For mesoscopic systems with size of a living cell, dynamics in (a and (c are stochastic while that with (b is dominantly deterministic. Both (b and (c are emergent properties of a dynamic biochemical network; We suggest that the (c is most relevant to major cellular biochemical processes such as epi-genetic regulation, apoptosis, and cancer immunoediting. The cellular evolution proceeds with transitions among the attractors of (b in a “punctuated equilibrium” manner.

  16. The chemical master equation approach to nonequilibrium steady-state of open biochemical systems: linear single-molecule enzyme kinetics and nonlinear biochemical reaction networks.

    Science.gov (United States)

    Qian, Hong; Bishop, Lisa M

    2010-01-01

    We develop the stochastic, chemical master equation as a unifying approach to the dynamics of biochemical reaction systems in a mesoscopic volume under a living environment. A living environment provides a continuous chemical energy input that sustains the reaction system in a nonequilibrium steady state with concentration fluctuations. We discuss the linear, unimolecular single-molecule enzyme kinetics, phosphorylation-dephosphorylation cycle (PdPC) with bistability, and network exhibiting oscillations. Emphasis is paid to the comparison between the stochastic dynamics and the prediction based on the traditional approach based on the Law of Mass Action. We introduce the difference between nonlinear bistability and stochastic bistability, the latter has no deterministic counterpart. For systems with nonlinear bistability, there are three different time scales: (a) individual biochemical reactions, (b) nonlinear network dynamics approaching to attractors, and (c) cellular evolution. For mesoscopic systems with size of a living cell, dynamics in (a) and (c) are stochastic while that with (b) is dominantly deterministic. Both (b) and (c) are emergent properties of a dynamic biochemical network; We suggest that the (c) is most relevant to major cellular biochemical processes such as epi-genetic regulation, apoptosis, and cancer immunoediting. The cellular evolution proceeds with transitions among the attractors of (b) in a "punctuated equilibrium" manner. PMID:20957107

  17. A Network-of-Networks Model for Electrical Infrastructure Networks

    CERN Document Server

    Halappanavar, Mahantesh; Hogan, Emilie; Duncan, Daniel; Zhenyu,; Huang,; Hines, Paul D H

    2015-01-01

    Modeling power transmission networks is an important area of research with applications such as vulnerability analysis, study of cascading failures, and location of measurement devices. Graph-theoretic approaches have been widely used to solve these problems, but are subject to several limitations. One of the limitations is the ability to model a heterogeneous system in a consistent manner using the standard graph-theoretic formulation. In this paper, we propose a {\\em network-of-networks} approach for modeling power transmission networks in order to explicitly incorporate heterogeneity in the model. This model distinguishes between different components of the network that operate at different voltage ratings, and also captures the intra and inter-network connectivity patterns. By building the graph in this fashion we present a novel, and fundamentally different, perspective of power transmission networks. Consequently, this novel approach will have a significant impact on the graph-theoretic modeling of powe...

  18. The slow-scale linear noise approximation: an accurate, reduced stochastic description of biochemical networks under timescale separation conditions

    Directory of Open Access Journals (Sweden)

    Thomas Philipp

    2012-05-01

    Full Text Available Abstract Background It is well known that the deterministic dynamics of biochemical reaction networks can be more easily studied if timescale separation conditions are invoked (the quasi-steady-state assumption. In this case the deterministic dynamics of a large network of elementary reactions are well described by the dynamics of a smaller network of effective reactions. Each of the latter represents a group of elementary reactions in the large network and has associated with it an effective macroscopic rate law. A popular method to achieve model reduction in the presence of intrinsic noise consists of using the effective macroscopic rate laws to heuristically deduce effective probabilities for the effective reactions which then enables simulation via the stochastic simulation algorithm (SSA. The validity of this heuristic SSA method is a priori doubtful because the reaction probabilities for the SSA have only been rigorously derived from microscopic physics arguments for elementary reactions. Results We here obtain, by rigorous means and in closed-form, a reduced linear Langevin equation description of the stochastic dynamics of monostable biochemical networks in conditions characterized by small intrinsic noise and timescale separation. The slow-scale linear noise approximation (ssLNA, as the new method is called, is used to calculate the intrinsic noise statistics of enzyme and gene networks. The results agree very well with SSA simulations of the non-reduced network of elementary reactions. In contrast the conventional heuristic SSA is shown to overestimate the size of noise for Michaelis-Menten kinetics, considerably under-estimate the size of noise for Hill-type kinetics and in some cases even miss the prediction of noise-induced oscillations. Conclusions A new general method, the ssLNA, is derived and shown to correctly describe the statistics of intrinsic noise about the macroscopic concentrations under timescale separation conditions

  19. Extracting protein regulatory networks with graphical models.

    Science.gov (United States)

    Grzegorczyk, Marco

    2007-09-01

    During the last decade the development of high-throughput biotechnologies has resulted in the production of exponentially expanding quantities of biological data, such as genomic and proteomic expression data. One fundamental problem in systems biology is to learn the architecture of biochemical pathways and regulatory networks in an inferential way from such postgenomic data. Along with the increasing amount of available data, a lot of novel statistical methods have been developed and proposed in the literature. This article gives a non-mathematical overview of three widely used reverse engineering methods, namely relevance networks, graphical Gaussian models, and Bayesian networks, whereby the focus is on their relative merits and shortcomings. In addition the reverse engineering results of these graphical methods on cytometric protein data from the RAF-signalling network are cross-compared via AUROC scatter plots. PMID:17893851

  20. Biochemical physics modeling of biological nano-motors

    Energy Technology Data Exchange (ETDEWEB)

    Santamaría-Holek, I.; López-Alamilla, N. J. [UMDI-Facultad de Ciencias, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, 76230 Querétaro (Mexico)

    2014-01-14

    We present a biochemical physics model accounting for the dynamics and energetics of both translational and rotational protein motors. A modified version of the hand-over-hand mechanism considering competitive inhibition by ADP is presented. Transition state-like theory is used to reconstruct the time dependent free-energy landscape of the cycle catalyst process that allows to predicting the number of steps or rotations that a single motor can perform. In addition, following the usual approach of chemical kinetics, we calculate the average translational velocity and also the stopping time of processes involving a collectivity of motors, such as exocytosis and endocytosis processes. Finally, we formulate a stochastic model reproducing very well single realizations of kinesin and rotary ATPases.

  1. Inverse fracture network modelling

    International Nuclear Information System (INIS)

    The basic problem in analyzing flow and transport in fractured rock is that the flow may be largely governed by a poorly connected network of fractures. Flow in such a system cannot be modeled with traditional modelling techniques. Fracture network models also have a limitation, in that they are based on geological data on fracture geometry even though it is known that only a small portion of fractures observed is hydraulically active. This paper discusses a new technique developed for treating the problem as well as presents a modelling example carried out to apply it. The approach is developed in Lawrence Berkeley Laboratory and it treats the fracture zone as an 'equivalent discontinuum'. The discontinuous nature of the problem is represented through flow on a partially filled lattice. An equivalent discontinuum model is constructed by adding and removing conductive elements through a statistical inverse technique called 'simulated annealing'. The fracture network model is 'annealed' until the modified systems behaves like the observed. The further development of the approach continues at LBL and in a joint LBL/VTT collaboration project the possibilities to apply the technique in Finnish conditions are investigated

  2. Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling.

    Science.gov (United States)

    Brown, Sherry-Ann; Moraru, Ion I; Schaff, James C; Loew, Leslie M

    2011-10-01

    Because of its highly branched dendrite, the Purkinje neuron requires significant computational resources if coupled electrical and biochemical activity are to be simulated. To address this challenge, we developed a scheme for reducing the geometric complexity; while preserving the essential features of activity in both the soma and a remote dendritic spine. We merged our previously published biochemical model of calcium dynamics and lipid signaling in the Purkinje neuron, developed in the Virtual Cell modeling and simulation environment, with an electrophysiological model based on a Purkinje neuron model available in NEURON. A novel reduction method was applied to the Purkinje neuron geometry to obtain a model with fewer compartments that is tractable in Virtual Cell. Most of the dendritic tree was subject to reduction, but we retained the neuron's explicit electrical and geometric features along a specified path from spine to soma. Further, unlike previous simplification methods, the dendrites that branch off along the preserved explicit path are retained as reduced branches. We conserved axial resistivity and adjusted passive properties and active channel conductances for the reduction in surface area, and cytosolic calcium for the reduction in volume. Rallpacks are used to validate the reduction algorithm and show that it can be generalized to other complex neuronal geometries. For the Purkinje cell, we found that current injections at the soma were able to produce similar trains of action potentials and membrane potential propagation in the full and reduced models in NEURON; the reduced model produces identical spiking patterns in NEURON and Virtual Cell. Importantly, our reduced model can simulate communication between the soma and a distal spine; an alpha function applied at the spine to represent synaptic stimulation gave similar results in the full and reduced models for potential changes associated with both the spine and the soma. Finally, we combined

  3. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks.

    Science.gov (United States)

    Biffi, Emilia; Piraino, Francesco; Pedrocchi, Alessandra; Fiore, Gianfranco B; Ferrigno, Giancarlo; Redaelli, Alberto; Menegon, Andrea; Rasponi, Marco

    2012-06-01

    Spatially and temporally resolved delivery of soluble factors is a key feature for pharmacological applications. In this framework, microfluidics coupled to multisite electrophysiology offers great advantages in neuropharmacology and toxicology. In this work, a microfluidic device for biochemical stimulation of neuronal networks was developed. A micro-chamber for cell culturing, previously developed and tested for long term neuronal growth by our group, was provided with a thin wall, which partially divided the cell culture region in two sub-compartments. The device was reversibly coupled to a flat micro electrode array and used to culture primary neurons in the same microenvironment. We demonstrated that the two fluidically connected compartments were able to originate two parallel neuronal networks with similar electrophysiological activity but functionally independent. Furthermore, the device allowed to connect the outlet port to a syringe pump and to transform the static culture chamber in a perfused one. At 14 days invitro, sub-networks were independently stimulated with a test molecule, tetrodotoxin, a neurotoxin known to block action potentials, by means of continuous delivery. Electrical activity recordings proved the ability of the device configuration to selectively stimulate each neuronal network individually. The proposed microfluidic approach represents an innovative methodology to perform biological, pharmacological, and electrophysiological experiments on neuronal networks. Indeed, it allows for controlled delivery of substances to cells, and it overcomes the limitations due to standard drug stimulation techniques. Finally, the twin network configuration reduces biological variability, which has important outcomes on pharmacological and drug screening. PMID:22655017

  4. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks.

    Science.gov (United States)

    Biffi, Emilia; Piraino, Francesco; Pedrocchi, Alessandra; Fiore, Gianfranco B; Ferrigno, Giancarlo; Redaelli, Alberto; Menegon, Andrea; Rasponi, Marco

    2012-06-01

    Spatially and temporally resolved delivery of soluble factors is a key feature for pharmacological applications. In this framework, microfluidics coupled to multisite electrophysiology offers great advantages in neuropharmacology and toxicology. In this work, a microfluidic device for biochemical stimulation of neuronal networks was developed. A micro-chamber for cell culturing, previously developed and tested for long term neuronal growth by our group, was provided with a thin wall, which partially divided the cell culture region in two sub-compartments. The device was reversibly coupled to a flat micro electrode array and used to culture primary neurons in the same microenvironment. We demonstrated that the two fluidically connected compartments were able to originate two parallel neuronal networks with similar electrophysiological activity but functionally independent. Furthermore, the device allowed to connect the outlet port to a syringe pump and to transform the static culture chamber in a perfused one. At 14 days invitro, sub-networks were independently stimulated with a test molecule, tetrodotoxin, a neurotoxin known to block action potentials, by means of continuous delivery. Electrical activity recordings proved the ability of the device configuration to selectively stimulate each neuronal network individually. The proposed microfluidic approach represents an innovative methodology to perform biological, pharmacological, and electrophysiological experiments on neuronal networks. Indeed, it allows for controlled delivery of substances to cells, and it overcomes the limitations due to standard drug stimulation techniques. Finally, the twin network configuration reduces biological variability, which has important outcomes on pharmacological and drug screening.

  5. Exact hybrid particle/population simulation of rule-based models of biochemical systems.

    Science.gov (United States)

    Hogg, Justin S; Harris, Leonard A; Stover, Lori J; Nair, Niketh S; Faeder, James R

    2014-04-01

    Detailed modeling and simulation of biochemical systems is complicated by the problem of combinatorial complexity, an explosion in the number of species and reactions due to myriad protein-protein interactions and post-translational modifications. Rule-based modeling overcomes this problem by representing molecules as structured objects and encoding their interactions as pattern-based rules. This greatly simplifies the process of model specification, avoiding the tedious and error prone task of manually enumerating all species and reactions that can potentially exist in a system. From a simulation perspective, rule-based models can be expanded algorithmically into fully-enumerated reaction networks and simulated using a variety of network-based simulation methods, such as ordinary differential equations or Gillespie's algorithm, provided that the network is not exceedingly large. Alternatively, rule-based models can be simulated directly using particle-based kinetic Monte Carlo methods. This "network-free" approach produces exact stochastic trajectories with a computational cost that is independent of network size. However, memory and run time costs increase with the number of particles, limiting the size of system that can be feasibly simulated. Here, we present a hybrid particle/population simulation method that combines the best attributes of both the network-based and network-free approaches. The method takes as input a rule-based model and a user-specified subset of species to treat as population variables rather than as particles. The model is then transformed by a process of "partial network expansion" into a dynamically equivalent form that can be simulated using a population-adapted network-free simulator. The transformation method has been implemented within the open-source rule-based modeling platform BioNetGen, and resulting hybrid models can be simulated using the particle-based simulator NFsim. Performance tests show that significant memory savings

  6. Exact hybrid particle/population simulation of rule-based models of biochemical systems.

    Directory of Open Access Journals (Sweden)

    Justin S Hogg

    2014-04-01

    Full Text Available Detailed modeling and simulation of biochemical systems is complicated by the problem of combinatorial complexity, an explosion in the number of species and reactions due to myriad protein-protein interactions and post-translational modifications. Rule-based modeling overcomes this problem by representing molecules as structured objects and encoding their interactions as pattern-based rules. This greatly simplifies the process of model specification, avoiding the tedious and error prone task of manually enumerating all species and reactions that can potentially exist in a system. From a simulation perspective, rule-based models can be expanded algorithmically into fully-enumerated reaction networks and simulated using a variety of network-based simulation methods, such as ordinary differential equations or Gillespie's algorithm, provided that the network is not exceedingly large. Alternatively, rule-based models can be simulated directly using particle-based kinetic Monte Carlo methods. This "network-free" approach produces exact stochastic trajectories with a computational cost that is independent of network size. However, memory and run time costs increase with the number of particles, limiting the size of system that can be feasibly simulated. Here, we present a hybrid particle/population simulation method that combines the best attributes of both the network-based and network-free approaches. The method takes as input a rule-based model and a user-specified subset of species to treat as population variables rather than as particles. The model is then transformed by a process of "partial network expansion" into a dynamically equivalent form that can be simulated using a population-adapted network-free simulator. The transformation method has been implemented within the open-source rule-based modeling platform BioNetGen, and resulting hybrid models can be simulated using the particle-based simulator NFsim. Performance tests show that

  7. SBMLsqueezer: A CellDesigner plug-in to generate kinetic rate equations for biochemical networks

    Directory of Open Access Journals (Sweden)

    Schröder Adrian

    2008-04-01

    Full Text Available Abstract Background The development of complex biochemical models has been facilitated through the standardization of machine-readable representations like SBML (Systems Biology Markup Language. This effort is accompanied by the ongoing development of the human-readable diagrammatic representation SBGN (Systems Biology Graphical Notation. The graphical SBML editor CellDesigner allows direct translation of SBGN into SBML, and vice versa. For the assignment of kinetic rate laws, however, this process is not straightforward, as it often requires manual assembly and specific knowledge of kinetic equations. Results SBMLsqueezer facilitates exactly this modeling step via automated equation generation, overcoming the highly error-prone and cumbersome process of manually assigning kinetic equations. For each reaction the kinetic equation is derived from the stoichiometry, the participating species (e.g., proteins, mRNA or simple molecules as well as the regulatory relations (activation, inhibition or other modulations of the SBGN diagram. Such information allows distinctions between, for example, translation, phosphorylation or state transitions. The types of kinetics considered are numerous, for instance generalized mass-action, Hill, convenience and several Michaelis-Menten-based kinetics, each including activation and inhibition. These kinetics allow SBMLsqueezer to cover metabolic, gene regulatory, signal transduction and mixed networks. Whenever multiple kinetics are applicable to one reaction, parameter settings allow for user-defined specifications. After invoking SBMLsqueezer, the kinetic formulas are generated and assigned to the model, which can then be simulated in CellDesigner or with external ODE solvers. Furthermore, the equations can be exported to SBML, LaTeX or plain text format. Conclusion SBMLsqueezer considers the annotation of all participating reactants, products and regulators when generating rate laws for reactions. Thus, for

  8. Synthesis and design of optimal biorefinery using an expanded network with thermochemical and biochemical biomass conversion platforms

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    2013-01-01

    This study presents the development of an expanded biorefinery processing network for producing biofuels that combines biochemical and thermochemical conversion platforms. The expanded network is coupled to a framework that uses a superstructure based optimization approach to generate and compare...... of 72 processing intervals . This superstructure was integrated with an earlier developed superstructure for biochemical conversion routes thereby forming a formidable number of biorefinery alternatives. The expanded network was demonstrated to be versatile and useful as a decision support tool...... for identifying at early stage optimal biorefinery concept with respect to technical, economic and environmental criteria....

  9. Connecting Biochemical Photosynthesis Models with Crop Models to Support Crop Improvement

    Science.gov (United States)

    Wu, Alex; Song, Youhong; van Oosterom, Erik J.; Hammer, Graeme L.

    2016-01-01

    The next advance in field crop productivity will likely need to come from improving crop use efficiency of resources (e.g., light, water, and nitrogen), aspects of which are closely linked with overall crop photosynthetic efficiency. Progress in genetic manipulation of photosynthesis is confounded by uncertainties of consequences at crop level because of difficulties connecting across scales. Crop growth and development simulation models that integrate across biological levels of organization and use a gene-to-phenotype modeling approach may present a way forward. There has been a long history of development of crop models capable of simulating dynamics of crop physiological attributes. Many crop models incorporate canopy photosynthesis (source) as a key driver for crop growth, while others derive crop growth from the balance between source- and sink-limitations. Modeling leaf photosynthesis has progressed from empirical modeling via light response curves to a more mechanistic basis, having clearer links to the underlying biochemical processes of photosynthesis. Cross-scale modeling that connects models at the biochemical and crop levels and utilizes developments in upscaling leaf-level models to canopy models has the potential to bridge the gap between photosynthetic manipulation at the biochemical level and its consequences on crop productivity. Here we review approaches to this emerging cross-scale modeling framework and reinforce the need for connections across levels of modeling. Further, we propose strategies for connecting biochemical models of photosynthesis into the cross-scale modeling framework to support crop improvement through photosynthetic manipulation.

  10. Coevolutionary modeling in network formation

    KAUST Repository

    Al-Shyoukh, Ibrahim

    2014-12-03

    Network coevolution, the process of network topology evolution in feedback with dynamical processes over the network nodes, is a common feature of many engineered and natural networks. In such settings, the change in network topology occurs at a comparable time scale to nodal dynamics. Coevolutionary modeling offers the possibility to better understand how and why network structures emerge. For example, social networks can exhibit a variety of structures, ranging from almost uniform to scale-free degree distributions. While current models of network formation can reproduce these structures, coevolutionary modeling can offer a better understanding of the underlying dynamics. This paper presents an overview of recent work on coevolutionary models of network formation, with an emphasis on the following three settings: (i) dynamic flow of benefits and costs, (ii) transient link establishment costs, and (iii) latent preferential attachment.

  11. Modelling Citation Networks

    CERN Document Server

    Goldberg, S R; Evans, T S

    2014-01-01

    The distribution of the number of academic publications as a function of citation count for a given year is remarkably similar from year to year. We measure this similarity as a width of the distribution and find it to be approximately constant from year to year. We show that simple citation models fail to capture this behaviour. We then provide a simple three parameter citation network model using a mixture of local and global search processes which can reproduce the correct distribution over time. We use the citation network of papers from the hep-th section of arXiv to test our model. For this data, around 20% of citations use global information to reference recently published papers, while the remaining 80% are found using local searches. We note that this is consistent with other studies though our motivation is very different from previous work. Finally, we also find that the fluctuations in the size of an academic publication's bibliography is important for the model. This is not addressed in most mode...

  12. Cellular automata modelling of biomolecular networks dynamics.

    Science.gov (United States)

    Bonchev, D; Thomas, S; Apte, A; Kier, L B

    2010-01-01

    The modelling of biological systems dynamics is traditionally performed by ordinary differential equations (ODEs). When dealing with intracellular networks of genes, proteins and metabolites, however, this approach is hindered by network complexity and the lack of experimental kinetic parameters. This opened the field for other modelling techniques, such as cellular automata (CA) and agent-based modelling (ABM). This article reviews this emerging field of studies on network dynamics in molecular biology. The basics of the CA technique are discussed along with an extensive list of related software and websites. The application of CA to networks of biochemical reactions is exemplified in detail by the case studies of the mitogen-activated protein kinase (MAPK) signalling pathway, the FAS-ligand (FASL)-induced and Bcl-2-related apoptosis. The potential of the CA method to model basic pathways patterns, to identify ways to control pathway dynamics and to help in generating strategies to fight with cancer is demonstrated. The different line of CA applications presented includes the search for the best-performing network motifs, an analysis of importance for effective intracellular signalling and pathway cross-talk. PMID:20373215

  13. Hierarchical graphs for rule-based modeling of biochemical systems

    Directory of Open Access Journals (Sweden)

    Hu Bin

    2011-02-01

    Full Text Available Abstract Background In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state of a component, and an edge represents a bond between components. Components of a molecule share the same color. Furthermore, graph-rewriting rules are used to represent molecular interactions. A rule that specifies addition (removal of an edge represents a class of association (dissociation reactions, and a rule that specifies a change of a vertex attribute represents a class of reactions that affect the internal state of a molecular component. A set of rules comprises an executable model that can be used to determine, through various means, the system-level dynamics of molecular interactions in a biochemical system. Results For purposes of model annotation, we propose the use of hierarchical graphs to represent structural relationships among components and subcomponents of molecules. We illustrate how hierarchical graphs can be used to naturally document the structural organization of the functional components and subcomponents of two proteins: the protein tyrosine kinase Lck and the T cell receptor (TCR complex. We also show that computational methods developed for regular graphs can be applied to hierarchical graphs. In particular, we describe a generalization of Nauty, a graph isomorphism and canonical labeling algorithm. The generalized version of the Nauty procedure, which we call HNauty, can be used to assign canonical labels to hierarchical graphs or more generally to graphs with multiple edge types. The difference between the Nauty and HNauty procedures is minor, but for completeness, we provide an explanation of the entire HNauty algorithm. Conclusions Hierarchical graphs provide more intuitive formal representations of proteins and other structured molecules with multiple functional components than do the regular graphs of current languages for

  14. A Network Synthesis Model for Generating Protein Interaction Network Families

    OpenAIRE

    Sayed Mohammad Ebrahim Sahraeian; Byung-Jun Yoon

    2012-01-01

    In this work, we introduce a novel network synthesis model that can generate families of evolutionarily related synthetic protein-protein interaction (PPI) networks. Given an ancestral network, the proposed model generates the network family according to a hypothetical phylogenetic tree, where the descendant networks are obtained through duplication and divergence of their ancestors, followed by network growth using network evolution models. We demonstrate that this network synthesis model ca...

  15. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems

    Science.gov (United States)

    Lomnitz, Jason G.; Savageau, Michael A.

    2016-01-01

    An overarching goal in molecular biology is to gain an understanding of the mechanistic basis underlying biochemical systems. Success is critical if we are to predict effectively the outcome of drug treatments and the development of abnormal phenotypes. However, data from most experimental studies is typically noisy and sparse. This allows multiple potential mechanisms to account for experimental observations, and often devising experiments to test each is not feasible. Here, we introduce a novel strategy that discriminates among putative models based on their repertoire of qualitatively distinct phenotypes, without relying on knowledge of specific values for rate constants and binding constants. As an illustration, we apply this strategy to two synthetic gene circuits exhibiting anomalous behaviors. Our results show that the conventional models, based on their well-characterized components, cannot account for the experimental observations. We examine a total of 40 alternative hypotheses and show that only 5 have the potential to reproduce the experimental data, and one can do so with biologically relevant parameter values. PMID:27578053

  16. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems.

    Science.gov (United States)

    Lomnitz, Jason G; Savageau, Michael A

    2016-01-01

    An overarching goal in molecular biology is to gain an understanding of the mechanistic basis underlying biochemical systems. Success is critical if we are to predict effectively the outcome of drug treatments and the development of abnormal phenotypes. However, data from most experimental studies is typically noisy and sparse. This allows multiple potential mechanisms to account for experimental observations, and often devising experiments to test each is not feasible. Here, we introduce a novel strategy that discriminates among putative models based on their repertoire of qualitatively distinct phenotypes, without relying on knowledge of specific values for rate constants and binding constants. As an illustration, we apply this strategy to two synthetic gene circuits exhibiting anomalous behaviors. Our results show that the conventional models, based on their well-characterized components, cannot account for the experimental observations. We examine a total of 40 alternative hypotheses and show that only 5 have the potential to reproduce the experimental data, and one can do so with biologically relevant parameter values. PMID:27578053

  17. A new computational method to split large biochemical networks into coherent subnets

    Directory of Open Access Journals (Sweden)

    Verwoerd Wynand S

    2011-02-01

    Full Text Available Abstract Background Compared to more general networks, biochemical networks have some special features: while generally sparse, there are a small number of highly connected metabolite nodes; and metabolite nodes can also be divided into two classes: internal nodes with associated mass balance constraints and external ones without. Based on these features, reclassifying selected internal nodes (separators to external ones can be used to divide a large complex metabolic network into simpler subnetworks. Selection of separators based on node connectivity is commonly used but affords little detailed control and tends to produce excessive fragmentation. The method proposed here (Netsplitter allows the user to control separator selection. It combines local connection degree partitioning with global connectivity derived from random walks on the network, to produce a more even distribution of subnetwork sizes. Partitioning is performed progressively and the interactive visual matrix presentation used allows the user considerable control over the process, while incorporating special strategies to maintain the network integrity and minimise the information loss due to partitioning. Results Partitioning of a genome scale network of 1348 metabolites and 1468 reactions for Arabidopsis thaliana encapsulates 66% of the network into 10 medium sized subnets. Applied to the flavonoid subnetwork extracted in this way, it is shown that Netsplitter separates this naturally into four subnets with recognisable functionality, namely synthesis of lignin precursors, flavonoids, coumarin and benzenoids. A quantitative quality measure called efficacy is constructed and shows that the new method gives improved partitioning for several metabolic networks, including bacterial, plant and mammal species. Conclusions For the examples studied the Netsplitter method is a considerable improvement on the performance of connection degree partitioning, giving a better balance of

  18. A neighbourhood evolving network model

    International Nuclear Information System (INIS)

    Many social, technological, biological and economical systems are best described by evolved network models. In this short Letter, we propose and study a new evolving network model. The model is based on the new concept of neighbourhood connectivity, which exists in many physical complex networks. The statistical properties and dynamics of the proposed model is analytically studied and compared with those of Barabasi-Albert scale-free model. Numerical simulations indicate that this network model yields a transition between power-law and exponential scaling, while the Barabasi-Albert scale-free model is only one of its special (limiting) cases. Particularly, this model can be used to enhance the evolving mechanism of complex networks in the real world, such as some social networks development

  19. Modeling biochemical transformation processes and information processing with Narrator

    Directory of Open Access Journals (Sweden)

    Palfreyman Niall M

    2007-03-01

    Full Text Available Abstract Background Software tools that model and simulate the dynamics of biological processes and systems are becoming increasingly important. Some of these tools offer sophisticated graphical user interfaces (GUIs, which greatly enhance their acceptance by users. Such GUIs are based on symbolic or graphical notations used to describe, interact and communicate the developed models. Typically, these graphical notations are geared towards conventional biochemical pathway diagrams. They permit the user to represent the transport and transformation of chemical species and to define inhibitory and stimulatory dependencies. A critical weakness of existing tools is their lack of supporting an integrative representation of transport, transformation as well as biological information processing. Results Narrator is a software tool facilitating the development and simulation of biological systems as Co-dependence models. The Co-dependence Methodology complements the representation of species transport and transformation together with an explicit mechanism to express biological information processing. Thus, Co-dependence models explicitly capture, for instance, signal processing structures and the influence of exogenous factors or events affecting certain parts of a biological system or process. This combined set of features provides the system biologist with a powerful tool to describe and explore the dynamics of life phenomena. Narrator's GUI is based on an expressive graphical notation which forms an integral part of the Co-dependence Methodology. Behind the user-friendly GUI, Narrator hides a flexible feature which makes it relatively easy to map models defined via the graphical notation to mathematical formalisms and languages such as ordinary differential equations, the Systems Biology Markup Language or Gillespie's direct method. This powerful feature facilitates reuse, interoperability and conceptual model development. Conclusion Narrator is a

  20. Mining and modeling character networks

    CERN Document Server

    Bonato, Anthony; Elenberg, Ethan R; Gleich, David F; Hou, Yangyang

    2016-01-01

    We investigate social networks of characters found in cultural works such as novels and films. These character networks exhibit many of the properties of complex networks such as skewed degree distribution and community structure, but may be of relatively small order with a high multiplicity of edges. Building on recent work of beveridge, we consider graph extraction, visualization, and network statistics for three novels: Twilight by Stephanie Meyer, Steven King's The Stand, and J.K. Rowling's Harry Potter and the Goblet of Fire. Coupling with 800 character networks from films found in the http://moviegalaxies.com/ database, we compare the data sets to simulations from various stochastic complex networks models including random graphs with given expected degrees (also known as the Chung-Lu model), the configuration model, and the preferential attachment model. Using machine learning techniques based on motif (or small subgraph) counts, we determine that the Chung-Lu model best fits character networks and we ...

  1. HRSSA - Efficient hybrid stochastic simulation for spatially homogeneous biochemical reaction networks

    Science.gov (United States)

    Marchetti, Luca; Priami, Corrado; Thanh, Vo Hong

    2016-07-01

    This paper introduces HRSSA (Hybrid Rejection-based Stochastic Simulation Algorithm), a new efficient hybrid stochastic simulation algorithm for spatially homogeneous biochemical reaction networks. HRSSA is built on top of RSSA, an exact stochastic simulation algorithm which relies on propensity bounds to select next reaction firings and to reduce the average number of reaction propensity updates needed during the simulation. HRSSA exploits the computational advantage of propensity bounds to manage time-varying transition propensities and to apply dynamic partitioning of reactions, which constitute the two most significant bottlenecks of hybrid simulation. A comprehensive set of simulation benchmarks is provided for evaluating performance and accuracy of HRSSA against other state of the art algorithms.

  2. Modeling Dynamics of Information Networks

    OpenAIRE

    Rosvall, Martin; Sneppen, Kim

    2003-01-01

    We propose an information-based model for network dynamics in which imperfect information leads to networks where the different vertices have widely different number of edges to other vertices, and where the topology has hierarchical features. The possibility to observe scale free networks is linked to a minimally connected system where hubs remain dynamic.

  3. Application of approximate pattern matching in two dimensional spaces to grid layout for biochemical network maps.

    Directory of Open Access Journals (Sweden)

    Kentaro Inoue

    Full Text Available BACKGROUND: For visualizing large-scale biochemical network maps, it is important to calculate the coordinates of molecular nodes quickly and to enhance the understanding or traceability of them. The grid layout is effective in drawing compact, orderly, balanced network maps with node label spaces, but existing grid layout algorithms often require a high computational cost because they have to consider complicated positional constraints through the entire optimization process. RESULTS: We propose a hybrid grid layout algorithm that consists of a non-grid, fast layout (preprocessor algorithm and an approximate pattern matching algorithm that distributes the resultant preprocessed nodes on square grid points. To demonstrate the feasibility of the hybrid layout algorithm, it is characterized in terms of the calculation time, numbers of edge-edge and node-edge crossings, relative edge lengths, and F-measures. The proposed algorithm achieves outstanding performances compared with other existing grid layouts. CONCLUSIONS: Use of an approximate pattern matching algorithm quickly redistributes the laid-out nodes by fast, non-grid algorithms on the square grid points, while preserving the topological relationships among the nodes. The proposed algorithm is a novel use of the pattern matching, thereby providing a breakthrough for grid layout. This application program can be freely downloaded from http://www.cadlive.jp/hybridlayout/hybridlayout.html.

  4. Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space

    Directory of Open Access Journals (Sweden)

    St Laurent Georges

    2010-03-01

    Full Text Available Abstract Background Signal transduction networks represent the information processing systems that dictate which dynamical regimes of biochemical activity can be accessible to a cell under certain circumstances. One of the major concerns in molecular systems biology is centered on the elucidation of the robustness properties and information processing capabilities of signal transduction networks. Achieving this goal requires the establishment of causal relations between the design principle of biochemical reaction systems and their emergent dynamical behaviors. Methods In this study, efforts were focused in the construction of a relatively well informed, deterministic, non-linear dynamic model, accounting for reaction mechanisms grounded on standard mass action and Hill saturation kinetics, of the canonical reaction topology underlying Toll-like receptor 4 (TLR4-mediated signaling events. This signaling mechanism has been shown to be deployed in macrophages during a relatively short time window in response to lypopolysaccharyde (LPS stimulation, which leads to a rapidly mounted innate immune response. An extensive computational exploration of the biochemical reaction space inhabited by this signal transduction network was performed via local and global perturbation strategies. Importantly, a broad spectrum of biologically plausible dynamical regimes accessible to the network in widely scattered regions of parameter space was reconstructed computationally. Additionally, experimentally reported transcriptional readouts of target pro-inflammatory genes, which are actively modulated by the network in response to LPS stimulation, were also simulated. This was done with the main goal of carrying out an unbiased statistical assessment of the intrinsic robustness properties of this canonical reaction topology. Results Our simulation results provide convincing numerical evidence supporting the idea that a canonical reaction mechanism of the TLR4

  5. Complex Networks in Psychological Models

    Science.gov (United States)

    Wedemann, R. S.; Carvalho, L. S. A. V. D.; Donangelo, R.

    We develop schematic, self-organizing, neural-network models to describe mechanisms associated with mental processes, by a neurocomputational substrate. These models are examples of real world complex networks with interesting general topological structures. Considering dopaminergic signal-to-noise neuronal modulation in the central nervous system, we propose neural network models to explain development of cortical map structure and dynamics of memory access, and unify different mental processes into a single neurocomputational substrate. Based on our neural network models, neurotic behavior may be understood as an associative memory process in the brain, and the linguistic, symbolic associative process involved in psychoanalytic working-through can be mapped onto a corresponding process of reconfiguration of the neural network. The models are illustrated through computer simulations, where we varied dopaminergic modulation and observed the self-organizing emergent patterns at the resulting semantic map, interpreting them as different manifestations of mental functioning, from psychotic through to normal and neurotic behavior, and creativity.

  6. Internet Network Resource Information Model

    Institute of Scientific and Technical Information of China (English)

    陈传峰; 李增智; 唐亚哲; 刘康平

    2002-01-01

    The foundation of any network management systens is a database that con-tains information about the network resources relevant to the management tasks. A networkinformation model is an abstraction of network resources, including both managed resources andmanaging resources. In the SNMP-based management framework, management information isdefined almost exclusively from a "device" viewpoint, namely, managing a network is equiva-lent to managing a collection of individual nodes. Aiming at making use of recent advances indistributed computing and in object-oriented analysis and design, the Internet management ar-chitecture can also be based on the Open Distributed Processing Reference Model (RM-ODP).The purpose of this article is to provide an Internet Network Resource Information Model.First, a layered management information architecture will be discussed. Then the Internetnetwork resource information model is presented. The information model is specified usingObject-Z.

  7. Development of a biochemical switching device: mathematical model.

    Science.gov (United States)

    Okamoto, M

    1990-01-01

    There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) and the applicability for a switching circuit in a biocomputer. The switching time was inevitably determined in accordance with the difference in amount between two inputs of the system. A unique switching mechanism of cyclic enzyme systems (basic switching element) and the effects of excitatory stimuli on switching properties of the integrated biochemical switching system are demonstrated. PMID:2082931

  8. Developing Personal Network Business Models

    DEFF Research Database (Denmark)

    Saugstrup, Dan; Henten, Anders

    2006-01-01

    The aim of the paper is to examine the issue of business modeling in relation to personal networks, PNs. The paper builds on research performed on business models in the EU 1ST MAGNET1 project (My personal Adaptive Global NET). The paper presents the Personal Network concept and briefly reports...... on the 'state of the art' in the field of business modeling. Furthermore, the paper suggests three generic business models for PNs: a service oriented model, a self-organized model, and a combination model. Finally, examples of relevant services and applications in relation to three different cases...... are presented and analyzed in light of business modeling of PN....

  9. Telecommunications network modelling, planning and design

    CERN Document Server

    Evans, Sharon

    2003-01-01

    Telecommunication Network Modelling, Planning and Design addresses sophisticated modelling techniques from the perspective of the communications industry and covers some of the major issues facing telecommunications network engineers and managers today. Topics covered include network planning for transmission systems, modelling of SDH transport network structures and telecommunications network design and performance modelling, as well as network costs and ROI modelling and QoS in 3G networks.

  10. Patterns of Stochastic Behavior in Dynamically Unstable High-Dimensional Biochemical Networks

    Directory of Open Access Journals (Sweden)

    Simon Rosenfeld

    2009-01-01

    Full Text Available The question of dynamical stability and stochastic behavior of large biochemical networks is discussed. It is argued that stringent conditions of asymptotic stability have very little chance to materialize in a multidimensional system described by the differential equations of chemical kinetics. The reason is that the criteria of asymptotic stability (Routh- Hurwitz, Lyapunov criteria, Feinberg’s Deficiency Zero theorem would impose the limitations of very high algebraic order on the kinetic rates and stoichiometric coefficients, and there are no natural laws that would guarantee their unconditional validity. Highly nonlinear, dynamically unstable systems, however, are not necessarily doomed to collapse, as a simple Jacobian analysis would suggest. It is possible that their dynamics may assume the form of pseudo-random fluctuations quite similar to a shot noise, and, therefore, their behavior may be described in terms of Langevin and Fokker-Plank equations. We have shown by simulation that the resulting pseudo-stochastic processes obey the heavy-tailed Generalized Pareto Distribution with temporal sequence of pulses forming the set of constituent-specific Poisson processes. Being applied to intracellular dynamics, these properties are naturally associated with burstiness, a well documented phenomenon in the biology of gene expression.

  11. Patterns of stochastic behavior in dynamically unstable high-dimensional biochemical networks.

    Science.gov (United States)

    Rosenfeld, Simon

    2009-01-29

    The question of dynamical stability and stochastic behavior of large biochemical networks is discussed. It is argued that stringent conditions of asymptotic stability have very little chance to materialize in a multidimensional system described by the differential equations of chemical kinetics. The reason is that the criteria of asymptotic stability (Routh-Hurwitz, Lyapunov criteria, Feinberg's Deficiency Zero theorem) would impose the limitations of very high algebraic order on the kinetic rates and stoichiometric coefficients, and there are no natural laws that would guarantee their unconditional validity. Highly nonlinear, dynamically unstable systems, however, are not necessarily doomed to collapse, as a simple Jacobian analysis would suggest. It is possible that their dynamics may assume the form of pseudo-random fluctuations quite similar to a shot noise, and, therefore, their behavior may be described in terms of Langevin and Fokker-Plank equations. We have shown by simulation that the resulting pseudo-stochastic processes obey the heavy-tailed Generalized Pareto Distribution with temporal sequence of pulses forming the set of constituent-specific Poisson processes. Being applied to intracellular dynamics, these properties are naturally associated with burstiness, a well documented phenomenon in the biology of gene expression.

  12. Modeling of some biochemical mechanisms of development of manganese hypermicroelementosis

    Directory of Open Access Journals (Sweden)

    O. V. Goncharenko

    2013-04-01

    , muscles, liver and spleen. It was accompanied by increasing calcium content in liver, heart, muscle, kidneys and bones as well as by disorders of Ca/Mg ratios. MnCl2causes significant redistribution of the microelements in the rats’ organs. It is characterized by a decrease of copper, zinc and nickel contents in almost all studied tissues. The most antagonistic effect of manganese manifested in relation to nickel and copper in heart and spleen. A reduction of zinc content was most pronounced in spleen, while its contents in bones and kidneys almost don’t change. The study of the impact of manganese on biochemical parameters of membranes proved for the first time the malfunction of erythrocytes’ membranes. It results in increasing sorption capacity of the red blood cells glycocalyx to alcian blue. Using the erythrocyte model we established that manganese cations cause a significant increase in sorption capacity of the red blood cells (53.4 ± 1.8% and their osmotic fragility, as evidenced by an increase of spontaneous hemolysis to 42%. The other evidence is the change of surface properties (glycocalyx, which indicated by an increase in the sialic acid content by 60% as compared with the control. The obtained data of the model study of the dynamics of the sorption capacity of erythrocytes glycocalyx to alcian blue, osmotic resistance of erythrocytes, activation of lipid peroxidation and increased level of sialic acid may be a signal that the primary mechanism of manganese intoxication is a damage of cell (plasma membranes. The data obtained on a mitochondrial model suggests that MnCl2, acting as an antagonist of magnesium, has the ability to disturb respiration and oxidative phosphorylation that inhibits the energy metabolism of a cell. Mitochondrial oxidation of malate+glutamate was affected by MnCl2 in narrow range concentrations 3–4.5 mM that cause disengagement (3 mM and complete inhibition (4.5 mM. The effectiveness of manganese intoxicated rats treatment

  13. Neural network modeling of emotion

    Science.gov (United States)

    Levine, Daniel S.

    2007-03-01

    This article reviews the history and development of computational neural network modeling of cognitive and behavioral processes that involve emotion. The exposition starts with models of classical conditioning dating from the early 1970s. Then it proceeds toward models of interactions between emotion and attention. Then models of emotional influences on decision making are reviewed, including some speculative (not and not yet simulated) models of the evolution of decision rules. Through the late 1980s, the neural networks developed to model emotional processes were mainly embodiments of significant functional principles motivated by psychological data. In the last two decades, network models of these processes have become much more detailed in their incorporation of known physiological properties of specific brain regions, while preserving many of the psychological principles from the earlier models. Most network models of emotional processes so far have dealt with positive and negative emotion in general, rather than specific emotions such as fear, joy, sadness, and anger. But a later section of this article reviews a few models relevant to specific emotions: one family of models of auditory fear conditioning in rats, and one model of induced pleasure enhancing creativity in humans. Then models of emotional disorders are reviewed. The article concludes with philosophical statements about the essential contributions of emotion to intelligent behavior and the importance of quantitative theories and models to the interdisciplinary enterprise of understanding the interactions of emotion, cognition, and behavior.

  14. Efficient Characterization of Parametric Uncertainty of Complex (Bio)chemical Networks.

    OpenAIRE

    Claudia Schillings; Mikael Sunnåker; Jörg Stelling; Christoph Schwab

    2015-01-01

    Parametric uncertainty is a particularly challenging and relevant aspect of systems analysis in domains such as systems biology where, both for inference and for assessing prediction uncertainties, it is essential to characterize the system behavior globally in the parameter space. However, current methods based on local approximations or on Monte-Carlo sampling cope only insufficiently with high-dimensional parameter spaces associated with complex network models. Here, we propose an alternat...

  15. Efficient Characterization of Parametric Uncertainty of Complex (Bio)chemical Networks

    OpenAIRE

    Claudia Schillings; Mikael Sunnåker; Jörg Stelling; Christoph Schwab

    2015-01-01

    Parametric uncertainty is a particularly challenging and relevant aspect of systems analysis in domains such as systems biology where, both for inference and for assessing prediction uncertainties, it is essential to characterize the system behavior globally in the parameter space. However, current methods based on local approximations or on Monte-Carlo sampling cope only insufficiently with high-dimensional parameter spaces associated with complex network models. Here, we propose an alternat...

  16. Investigating modularity in the analysis of process algebra models of biochemical systems

    CERN Document Server

    Ciocchetta, Federica; Hillston, Jane; 10.4204/EPTCS.19.4

    2010-01-01

    Compositionality is a key feature of process algebras which is often cited as one of their advantages as a modelling technique. It is certainly true that in biochemical systems, as in many other systems, model construction is made easier in a formalism which allows the problem to be tackled compositionally. In this paper we consider the extent to which the compositional structure which is inherent in process algebra models of biochemical systems can be exploited during model solution. In essence this means using the compositional structure to guide decomposed solution and analysis. Unfortunately the dynamic behaviour of biochemical systems exhibits strong interdependencies between the components of the model making decomposed solution a difficult task. Nevertheless we believe that if such decomposition based on process algebras could be established it would demonstrate substantial benefits for systems biology modelling. In this paper we present our preliminary investigations based on a case study of the phero...

  17. Simplified models of biological networks.

    Science.gov (United States)

    Sneppen, Kim; Krishna, Sandeep; Semsey, Szabolcs

    2010-01-01

    The function of living cells is controlled by complex regulatory networks that are built of a wide diversity of interacting molecular components. The sheer size and intricacy of molecular networks of even the simplest organisms are obstacles toward understanding network functionality. This review discusses the achievements and promise of a bottom-up approach that uses well-characterized subnetworks as model systems for understanding larger networks. It highlights the interplay between the structure, logic, and function of various types of small regulatory circuits. The bottom-up approach advocates understanding regulatory networks as a collection of entangled motifs. We therefore emphasize the potential of negative and positive feedback, as well as their combinations, to generate robust homeostasis, epigenetics, and oscillations. PMID:20192769

  18. Advances in theoretical models of network science

    Institute of Scientific and Technical Information of China (English)

    FANG Jin-qing; BI Qiao; LI Yong

    2007-01-01

    In this review article, we will summarize the main advances in network science investigated by the CIAE Group of Complex Network in this field. Several theoretical models of network science were proposed and their topological and dynamical properties are reviewed and compared with the other models. Our models mainly include a harmonious unifying hybrid preferential model, a large unifying hybrid network model, a quantum interference network, a hexagonal nanowire network, and a small-world network with the same degree. The models above reveal some new phenomena and findings, which are useful for deeply understanding and investigating complex networks and their applications.

  19. Current approaches to gene regulatory network modelling

    Directory of Open Access Journals (Sweden)

    Brazma Alvis

    2007-09-01

    Full Text Available Abstract Many different approaches have been developed to model and simulate gene regulatory networks. We proposed the following categories for gene regulatory network models: network parts lists, network topology models, network control logic models, and dynamic models. Here we will describe some examples for each of these categories. We will study the topology of gene regulatory networks in yeast in more detail, comparing a direct network derived from transcription factor binding data and an indirect network derived from genome-wide expression data in mutants. Regarding the network dynamics we briefly describe discrete and continuous approaches to network modelling, then describe a hybrid model called Finite State Linear Model and demonstrate that some simple network dynamics can be simulated in this model.

  20. River water quality model no. 1 (RWQM1): II. Biochemical process equations

    DEFF Research Database (Denmark)

    Reichert, P.; Borchardt, D.; Henze, Mogens;

    2001-01-01

    In this paper, biochemical process equations are presented as a basis for water quality modelling in rivers under aerobic and anoxic conditions. These equations are not new, but they summarise parts of the development over the past 75 years. The primary goals of the presentation are to stimulate...... communication among modellers and field-oriented researchers of river water quality and of wastewater treatment, to facilitate practical application of river water quality modelling, and to encourage the use of elemental mass balances for the derivation of stoichiometric coefficients of biochemical...

  1. A Multilayer Model of Computer Networks

    OpenAIRE

    Shchurov, Andrey A.

    2015-01-01

    The fundamental concept of applying the system methodology to network analysis declares that network architecture should take into account services and applications which this network provides and supports. This work introduces a formal model of computer networks on the basis of the hierarchical multilayer networks. In turn, individual layers are represented as multiplex networks. The concept of layered networks provides conditions of top-down consistency of the model. Next, we determined the...

  2. Target-Centric Network Modeling

    DEFF Research Database (Denmark)

    Mitchell, Dr. William L.; Clark, Dr. Robert M.

    In Target-Centric Network Modeling: Case Studies in Analyzing Complex Intelligence Issues, authors Robert Clark and William Mitchell take an entirely new approach to teaching intelligence analysis. Unlike any other book on the market, it offers case study scenarios using actual intelligence...... reporting formats, along with a tested process that facilitates the production of a wide range of analytical products for civilian, military, and hybrid intelligence environments. Readers will learn how to perform the specific actions of problem definition modeling, target network modeling......, and collaborative sharing in the process of creating a high-quality, actionable intelligence product. The case studies reflect the complexity of twenty-first century intelligence issues by dealing with multi-layered target networks that cut across political, economic, social, technological, and military issues...

  3. Network analysis of biochemical logic for noise reduction and stability: a system of three coupled enzymatic and gates.

    Science.gov (United States)

    Privman, Vladimir; Arugula, Mary A; Halámek, Jan; Pita, Marcos; Katz, Evgeny

    2009-04-16

    We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymatic AND gates are reported, illustrating our procedure. Specifically, starch, one of the controlled network inputs, is converted to maltose by beta-amylase. With the use of phosphate (another controlled input), maltose phosphorylase then produces glucose. Finally, nicotinamide adenine dinucleotide (NAD(+)), the third controlled input, is reduced under the action of glucose dehydrogenase to yield the optically detected signal. Network functioning is analyzed by varying selective inputs and fitting standardized few-parameters "response-surface" functions assumed for each gate. This allows a certain probe of the individual gate quality, but primarily yields information on the relative contribution of the gates to noise amplification. The derived information is then used to modify our experimental system to put it in a regime of a less noisy operation.

  4. Hydraulic Modeling: Pipe Network Analysis

    OpenAIRE

    Datwyler, Trevor T.

    2012-01-01

    Water modeling is becoming an increasingly important part of hydraulic engineering. One application of hydraulic modeling is pipe network analysis. Using programmed algorithms to repeatedly solve continuity and energy equations, computer software can greatly reduce the amount of time required to analyze a closed conduit system. Such hydraulic models can become a valuable tool for cities to maintain their water systems and plan for future growth. The Utah Division of Drinking Water regulations...

  5. Efficient Characterization of Parametric Uncertainty of Complex (Bio)chemical Networks.

    Science.gov (United States)

    Schillings, Claudia; Sunnåker, Mikael; Stelling, Jörg; Schwab, Christoph

    2015-08-01

    Parametric uncertainty is a particularly challenging and relevant aspect of systems analysis in domains such as systems biology where, both for inference and for assessing prediction uncertainties, it is essential to characterize the system behavior globally in the parameter space. However, current methods based on local approximations or on Monte-Carlo sampling cope only insufficiently with high-dimensional parameter spaces associated with complex network models. Here, we propose an alternative deterministic methodology that relies on sparse polynomial approximations. We propose a deterministic computational interpolation scheme which identifies most significant expansion coefficients adaptively. We present its performance in kinetic model equations from computational systems biology with several hundred parameters and state variables, leading to numerical approximations of the parametric solution on the entire parameter space. The scheme is based on adaptive Smolyak interpolation of the parametric solution at judiciously and adaptively chosen points in parameter space. As Monte-Carlo sampling, it is "non-intrusive" and well-suited for massively parallel implementation, but affords higher convergence rates. This opens up new avenues for large-scale dynamic network analysis by enabling scaling for many applications, including parameter estimation, uncertainty quantification, and systems design. PMID:26317784

  6. Efficient Characterization of Parametric Uncertainty of Complex (Bio)chemical Networks.

    Science.gov (United States)

    Schillings, Claudia; Sunnåker, Mikael; Stelling, Jörg; Schwab, Christoph

    2015-08-01

    Parametric uncertainty is a particularly challenging and relevant aspect of systems analysis in domains such as systems biology where, both for inference and for assessing prediction uncertainties, it is essential to characterize the system behavior globally in the parameter space. However, current methods based on local approximations or on Monte-Carlo sampling cope only insufficiently with high-dimensional parameter spaces associated with complex network models. Here, we propose an alternative deterministic methodology that relies on sparse polynomial approximations. We propose a deterministic computational interpolation scheme which identifies most significant expansion coefficients adaptively. We present its performance in kinetic model equations from computational systems biology with several hundred parameters and state variables, leading to numerical approximations of the parametric solution on the entire parameter space. The scheme is based on adaptive Smolyak interpolation of the parametric solution at judiciously and adaptively chosen points in parameter space. As Monte-Carlo sampling, it is "non-intrusive" and well-suited for massively parallel implementation, but affords higher convergence rates. This opens up new avenues for large-scale dynamic network analysis by enabling scaling for many applications, including parameter estimation, uncertainty quantification, and systems design.

  7. Thermal Network Modelling Handbook

    Science.gov (United States)

    1972-01-01

    Thermal mathematical modelling is discussed in detail. A three-fold purpose was established: (1) to acquaint the new user with the terminology and concepts used in thermal mathematical modelling, (2) to present the more experienced and occasional user with quick formulas and methods for solving everyday problems, coupled with study cases which lend insight into the relationships that exist among the various solution techniques and parameters, and (3) to begin to catalog in an orderly fashion the common formulas which may be applied to automated conversational language techniques.

  8. Stochastic focusing coupled with negative feedback enables robust regulation in biochemical reaction networks.

    Science.gov (United States)

    Milias-Argeitis, Andreas; Engblom, Stefan; Bauer, Pavol; Khammash, Mustafa

    2015-12-01

    Nature presents multiple intriguing examples of processes that proceed with high precision and regularity. This remarkable stability is frequently counter to modellers' experience with the inherent stochasticity of chemical reactions in the regime of low-copy numbers. Moreover, the effects of noise and nonlinearities can lead to 'counterintuitive' behaviour, as demonstrated for a basic enzymatic reaction scheme that can display stochastic focusing (SF). Under the assumption of rapid signal fluctuations, SF has been shown to convert a graded response into a threshold mechanism, thus attenuating the detrimental effects of signal noise. However, when the rapid fluctuation assumption is violated, this gain in sensitivity is generally obtained at the cost of very large product variance, and this unpredictable behaviour may be one possible explanation of why, more than a decade after its introduction, SF has still not been observed in real biochemical systems. In this work, we explore the noise properties of a simple enzymatic reaction mechanism with a small and fluctuating number of active enzymes that behaves as a high-gain, noisy amplifier due to SF caused by slow enzyme fluctuations. We then show that the inclusion of a plausible negative feedback mechanism turns the system from a noisy signal detector to a strong homeostatic mechanism by exchanging high gain with strong attenuation in output noise and robustness to parameter variations. Moreover, we observe that the discrepancy between deterministic and stochastic descriptions of stochastically focused systems in the evolution of the means almost completely disappears, despite very low molecule counts and the additional nonlinearity due to feedback. The reaction mechanism considered here can provide a possible resolution to the apparent conflict between intrinsic noise and high precision in critical intracellular processes. PMID:26609065

  9. Modeling photosynthesis of discontinuous plant canopies by linking Geometric Optical Radiative Transfer model with biochemical processes

    Science.gov (United States)

    Xin, Q.; Gong, P.; Li, W.

    2015-02-01

    Modeling vegetation photosynthesis is essential for understanding carbon exchanges between terrestrial ecosystems and the atmosphere. The radiative transfer process within plant canopies is one of the key drivers that regulate canopy photosynthesis. Most vegetation cover consists of discrete plant crowns, of which the physical observation departs from the underlying assumption of a homogenous and uniform medium in classic radiative transfer theory. Here we advance the Geometric Optical Radiative Transfer (GORT) model to simulate photosynthesis activities for discontinuous plant canopies. We separate radiation absorption into two components that are absorbed by sunlit and shaded leaves, and derive analytical solutions by integrating over the canopy layer. To model leaf-level and canopy-level photosynthesis, leaf light absorption is then linked to the biochemical process of gas diffusion through leaf stomata. The canopy gap probability derived from GORT differs from classic radiative transfer theory, especially when the leaf area index is high, due to leaf clumping effects. Tree characteristics such as tree density, crown shape, and canopy length affect leaf clumping and regulate radiation interception. Modeled gross primary production (GPP) for two deciduous forest stands could explain more than 80% of the variance of flux tower measurements at both near hourly and daily time scales. We also demonstrate that the ambient CO2 concentration influences daytime vegetation photosynthesis, which needs to be considered in state-of-the-art biogeochemical models. The proposed model is complementary to classic radiative transfer theory and shows promise in modeling the radiative transfer process and photosynthetic activities over discontinuous forest canopies.

  10. Influence of site and age on biochemical characteristics of the collagen network of equine articular cartilage

    NARCIS (Netherlands)

    Brama, P.A.J.; TeKoppele, J.M.; Bank, R.A.; Weeren, P.R. van; Barneveld, A.

    1999-01-01

    Objective - To determine variations in biochemical characteristics of equine articular cartilage in relation to age and the degree of predisposition for osteochondral disease at a specific site. Sample Population - Articular cartilage specimens from 53 horses 4 to 30 years old. Procedure - Healthy s

  11. CNEM: Cluster Based Network Evolution Model

    Directory of Open Access Journals (Sweden)

    Sarwat Nizamani

    2015-01-01

    Full Text Available This paper presents a network evolution model, which is based on the clustering approach. The proposed approach depicts the network evolution, which demonstrates the network formation from individual nodes to fully evolved network. An agglomerative hierarchical clustering method is applied for the evolution of network. In the paper, we present three case studies which show the evolution of the networks from the scratch. These case studies include: terrorist network of 9/11 incidents, terrorist network of WMD (Weapons Mass Destruction plot against France and a network of tweets discussing a topic. The network of 9/11 is also used for evaluation, using other social network analysis methods which show that the clusters created using the proposed model of network evolution are of good quality, thus the proposed method can be used by law enforcement agencies in order to further investigate the criminal networks

  12. Modelling and Analysis of Biochemical Signalling Pathway Cross-talk

    CERN Document Server

    Donaldson, Robin; 10.4204/EPTCS.19.3

    2010-01-01

    Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing the correct signal-response relationship. Formal models of signalling pathways and cross-talk in particular can aid understanding and drive experimentation. We define an approach to modelling based on the concept that a pathway is the (synchronising) parallel composition of instances of generic modules (with internal and external labels). Pathways are then composed by (synchronising) parallel composition and renaming; different types of cross-talk result from different combinations of synchronisation and renaming. We define a number of generic modules in PRISM and five types of cross-talk: signal flow, substrate availability, receptor function, gene expression and intracellular communication. We show that Continuous Stochastic Logic properties can both detect an...

  13. Gray box modeling of MSW degradation: Revealing its dominant (bio)chemical mechanism

    NARCIS (Netherlands)

    Van Turnhout, A.G.; Heimovaara, T.J.; Kleerebezem, R.

    2013-01-01

    In this paper we present an approach to describe organic degradation within immobile water regions of Municipal Solid Waste (MSW) landfills which is best described by the term “gray box” model. We use a simplified set of dominant (bio)chemical and physical reactions and realistic environmental condi

  14. Biochemical Production of Ethanol from Corn Stover: 2007 State of Technology Model

    Energy Technology Data Exchange (ETDEWEB)

    Aden, Andy [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2008-05-01

    Since 2001, NREL has kept track of technical research progress in the biochemical process through what are known as “State of Technology” (SOT) assessments. The purpose of this report is to update the FY 2005 SOT model with the latest research results from the past two years.

  15. Molecular paleontology: a biochemical model of the ancestral ribosome

    OpenAIRE

    Hsiao, Chiaolong; Lenz, Timothy K.; Peters, Jessica K; Fang, Po-Yu; Schneider, Dana M.; Anderson, Eric J.; Preeprem, Thanawadee; Bowman, Jessica C.; O'Neill, Eric B.; Lie, Lively; Athavale, Shreyas S.; Gossett, J. Jared; Trippe, Catherine; Murray, Jason; Anton S. Petrov

    2013-01-01

    Ancient components of the ribosome, inferred from a consensus of previous work, were constructed in silico, in vitro and in vivo. The resulting model of the ancestral ribosome presented here incorporates ∼20% of the extant 23S rRNA and fragments of five ribosomal proteins. We test hypotheses that ancestral rRNA can: (i) assume canonical 23S rRNA-like secondary structure, (ii) assume canonical tertiary structure and (iii) form native complexes with ribosomal protein fragments. Footprinting exp...

  16. A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase

    OpenAIRE

    Senkevitch, Emilee; Cabrera-Luque, Juan; Morizono, Hiroki; Caldovic, Ljubica; Tuchman, Mendel

    2012-01-01

    All knockout mouse models of urea cycle disorders die in the neonatal period or shortly thereafter. Since N-acetylglutamate synthase (NAGS) deficiency in humans can be effectively treated with N-carbamyl-L-glutamate (NCG), we sought to develop a mouse model of this disorder that could be rescued by biochemical intervention, reared to adulthood, reproduce, and become a novel animal model for hyperammonemia. Founder NAGS knockout heterozygous mice were obtained from the trans-NIH Knock-Out Mous...

  17. Osseointegration of biochemically modified implants in an osteoporosis rodent model

    Directory of Open Access Journals (Sweden)

    B Stadlinger

    2013-07-01

    Full Text Available The present study examined the impact of implant surface modifications on osseointegration in an osteoporotic rodent model. Sandblasted, acid-etched titanium implants were either used directly (control or were further modified by surface conditioning with NaOH or by coating with one of the following active agents: collagen/chondroitin sulphate, simvastatin, or zoledronic acid. Control and modified implants were inserted into the proximal tibia of aged ovariectomised (OVX osteoporotic rats (n = 32/group. In addition, aged oestrogen competent animals received either control or NaOH conditioned implants. Animals were sacrificed 2 and 4 weeks post-implantation. The excised tibiae were utilised for biomechanical and morphometric readouts (n = 8/group/readout. Biomechanical testing revealed at both time points dramatically reduced osseointegration in the tibia of oestrogen deprived osteoporotic animals compared to intact controls irrespective of NaOH exposure. Consistently, histomorphometric and microCT analyses demonstrated diminished bone-implant contact (BIC, peri-implant bone area (BA, bone volume/tissue volume (BV/TV and bone-mineral density (BMD in OVX animals. Surface coating with collagen/chondroitin sulphate had no detectable impact on osseointegration. Interestingly, statin coating resulted in a transient increase in BIC 2 weeks post-implantation; which, however, did not correspond to improvement of biomechanical readouts. Local exposure to zoledronic acid increased BIC, BA, BV/TV and BMD at 4 weeks. Yet this translated only into a non-significant improvement of biomechanical properties. In conclusion, this study presents a rodent model mimicking severely osteoporotic bone. Contrary to the other bioactive agents, locally released zoledronic acid had a positive impact on osseointegration albeit to a lesser extent than reported in less challenging models.

  18. Boolean network model predicts cell cycle sequence of fission yeast.

    Directory of Open Access Journals (Sweden)

    Maria I Davidich

    Full Text Available A Boolean network model of the cell-cycle regulatory network of fission yeast (Schizosaccharomyces Pombe is constructed solely on the basis of the known biochemical interaction topology. Simulating the model in the computer faithfully reproduces the known activity sequence of regulatory proteins along the cell cycle of the living cell. Contrary to existing differential equation models, no parameters enter the model except the structure of the regulatory circuitry. The dynamical properties of the model indicate that the biological dynamical sequence is robustly implemented in the regulatory network, with the biological stationary state G1 corresponding to the dominant attractor in state space, and with the biological regulatory sequence being a strongly attractive trajectory. Comparing the fission yeast cell-cycle model to a similar model of the corresponding network in S. cerevisiae, a remarkable difference in circuitry, as well as dynamics is observed. While the latter operates in a strongly damped mode, driven by external excitation, the S. pombe network represents an auto-excited system with external damping.

  19. Modelling and Analysis of Biochemical Signalling Pathway Cross-talk

    Directory of Open Access Journals (Sweden)

    Robin Donaldson

    2010-02-01

    Full Text Available Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing the correct signal-response relationship. Formal models of signalling pathways and cross-talk in particular can aid understanding and drive experimentation. We define an approach to modelling based on the concept that a pathway is the (synchronising parallel composition of instances of generic modules (with internal and external labels. Pathways are then composed by (synchronising parallel composition and renaming; different types of cross-talk result from different combinations of synchronisation and renaming. We define a number of generic modules in PRISM and five types of cross-talk: signal flow, substrate availability, receptor function, gene expression and intracellular communication. We show that Continuous Stochastic Logic properties can both detect and distinguish the types of cross-talk. The approach is illustrated with small examples and an analysis of the cross-talk between the TGF-b/BMP, WNT and MAPK pathways.

  20. Research on the model of home networking

    Science.gov (United States)

    Yun, Xiang; Feng, Xiancheng

    2007-11-01

    It is the research hotspot of current broadband network to combine voice service, data service and broadband audio-video service by IP protocol to transport various real time and mutual services to terminal users (home). Home Networking is a new kind of network and application technology which can provide various services. Home networking is called as Digital Home Network. It means that PC, home entertainment equipment, home appliances, Home wirings, security, illumination system were communicated with each other by some composing network technology, constitute a networking internal home, and connect with WAN by home gateway. It is a new network technology and application technology, and can provide many kinds of services inside home or between homes. Currently, home networking can be divided into three kinds: Information equipment, Home appliances, Communication equipment. Equipment inside home networking can exchange information with outer networking by home gateway, this information communication is bidirectional, user can get information and service which provided by public networking by using home networking internal equipment through home gateway connecting public network, meantime, also can get information and resource to control the internal equipment which provided by home networking internal equipment. Based on the general network model of home networking, there are four functional entities inside home networking: HA, HB, HC, and HD. (1) HA (Home Access) - home networking connects function entity; (2) HB (Home Bridge) Home networking bridge connects function entity; (3) HC (Home Client) - Home networking client function entity; (4) HD (Home Device) - decoder function entity. There are many physical ways to implement four function entities. Based on theses four functional entities, there are reference model of physical layer, reference model of link layer, reference model of IP layer and application reference model of high layer. In the future home network

  1. Modeling integrated cellular machinery using hybrid Petri-Boolean networks.

    Directory of Open Access Journals (Sweden)

    Natalie Berestovsky

    Full Text Available The behavior and phenotypic changes of cells are governed by a cellular circuitry that represents a set of biochemical reactions. Based on biological functions, this circuitry is divided into three types of networks, each encoding for a major biological process: signal transduction, transcription regulation, and metabolism. This division has generally enabled taming computational complexity dealing with the entire system, allowed for using modeling techniques that are specific to each of the components, and achieved separation of the different time scales at which reactions in each of the three networks occur. Nonetheless, with this division comes loss of information and power needed to elucidate certain cellular phenomena. Within the cell, these three types of networks work in tandem, and each produces signals and/or substances that are used by the others to process information and operate normally. Therefore, computational techniques for modeling integrated cellular machinery are needed. In this work, we propose an integrated hybrid model (IHM that combines Petri nets and Boolean networks to model integrated cellular networks. Coupled with a stochastic simulation mechanism, the model simulates the dynamics of the integrated network, and can be perturbed to generate testable hypotheses. Our model is qualitative and is mostly built upon knowledge from the literature and requires fine-tuning of very few parameters. We validated our model on two systems: the transcriptional regulation of glucose metabolism in human cells, and cellular osmoregulation in S. cerevisiae. The model produced results that are in very good agreement with experimental data, and produces valid hypotheses. The abstract nature of our model and the ease of its construction makes it a very good candidate for modeling integrated networks from qualitative data. The results it produces can guide the practitioner to zoom into components and interconnections and investigate them

  2. Mathematical Modelling Plant Signalling Networks

    KAUST Repository

    Muraro, D.

    2013-01-01

    During the last two decades, molecular genetic studies and the completion of the sequencing of the Arabidopsis thaliana genome have increased knowledge of hormonal regulation in plants. These signal transduction pathways act in concert through gene regulatory and signalling networks whose main components have begun to be elucidated. Our understanding of the resulting cellular processes is hindered by the complex, and sometimes counter-intuitive, dynamics of the networks, which may be interconnected through feedback controls and cross-regulation. Mathematical modelling provides a valuable tool to investigate such dynamics and to perform in silico experiments that may not be easily carried out in a laboratory. In this article, we firstly review general methods for modelling gene and signalling networks and their application in plants. We then describe specific models of hormonal perception and cross-talk in plants. This mathematical analysis of sub-cellular molecular mechanisms paves the way for more comprehensive modelling studies of hormonal transport and signalling in a multi-scale setting. © EDP Sciences, 2013.

  3. Biochemical switching device: biomimetic approach and application to neural network study.

    Science.gov (United States)

    Okamoto, M

    1992-06-01

    There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) capable of storing short-memory, and the applicability for a switching circuit in a biocomputer. This paper introduces a unique switching mechanism of cyclic enzyme system (basic switching element), and next, building the integrated biochemical switching system being composed of the basic switching element, shows the physiological phenomenon termed 'selective elimination of synapses' generally produced as a result of low-frequency train of electrical stimuli to the synapses (Kuroda, Y. 1989) Neurochem. Int. 14, 309-319). PMID:1368350

  4. Generalization performance of regularized neural network models

    DEFF Research Database (Denmark)

    Larsen, Jan; Hansen, Lars Kai

    1994-01-01

    Architecture optimization is a fundamental problem of neural network modeling. The optimal architecture is defined as the one which minimizes the generalization error. This paper addresses estimation of the generalization performance of regularized, complete neural network models. Regularization...

  5. Probabilistic logic modeling of network reliability for hybrid network architectures

    Energy Technology Data Exchange (ETDEWEB)

    Wyss, G.D.; Schriner, H.K.; Gaylor, T.R.

    1996-10-01

    Sandia National Laboratories has found that the reliability and failure modes of current-generation network technologies can be effectively modeled using fault tree-based probabilistic logic modeling (PLM) techniques. We have developed fault tree models that include various hierarchical networking technologies and classes of components interconnected in a wide variety of typical and atypical configurations. In this paper we discuss the types of results that can be obtained from PLMs and why these results are of great practical value to network designers and analysts. After providing some mathematical background, we describe the `plug-and-play` fault tree analysis methodology that we have developed for modeling connectivity and the provision of network services in several current- generation network architectures. Finally, we demonstrate the flexibility of the method by modeling the reliability of a hybrid example network that contains several interconnected ethernet, FDDI, and token ring segments. 11 refs., 3 figs., 1 tab.

  6. An evolving network model with community structure

    International Nuclear Information System (INIS)

    Many social and biological networks consist of communities-groups of nodes within which connections are dense, but between which connections are sparser. Recently, there has been considerable interest in designing algorithms for detecting community structures in real-world complex networks. In this paper, we propose an evolving network model which exhibits community structure. The network model is based on the inner-community preferential attachment and inter-community preferential attachment mechanisms. The degree distributions of this network model are analysed based on a mean-field method. Theoretical results and numerical simulations indicate that this network model has community structure and scale-free properties

  7. Brand Marketing Model on Social Networks

    Directory of Open Access Journals (Sweden)

    Jolita Jezukevičiūtė

    2014-04-01

    Full Text Available The paper analyzes the brand and its marketing solutions onsocial networks. This analysis led to the creation of improvedbrand marketing model on social networks, which will contributeto the rapid and cheap organization brand recognition, increasecompetitive advantage and enhance consumer loyalty. Therefore,the brand and a variety of social networks are becoming a hotresearch area for brand marketing model on social networks.The world‘s most successful brand marketing models exploratoryanalysis of a single case study revealed a brand marketingsocial networking tools that affect consumers the most. Basedon information analysis and methodological studies, develop abrand marketing model on social networks.

  8. Modeling the Dynamics of Compromised Networks

    Energy Technology Data Exchange (ETDEWEB)

    Soper, B; Merl, D M

    2011-09-12

    Accurate predictive models of compromised networks would contribute greatly to improving the effectiveness and efficiency of the detection and control of network attacks. Compartmental epidemiological models have been applied to modeling attack vectors such as viruses and worms. We extend the application of these models to capture a wider class of dynamics applicable to cyber security. By making basic assumptions regarding network topology we use multi-group epidemiological models and reaction rate kinetics to model the stochastic evolution of a compromised network. The Gillespie Algorithm is used to run simulations under a worst case scenario in which the intruder follows the basic connection rates of network traffic as a method of obfuscation.

  9. Assimilation of ocean colour data into a Biochemical Flux Model of the Eastern Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    G. Triantafyllou

    2006-09-01

    Full Text Available Within the framework of the European MFSTEP project, an advanced multivariate sequential data assimilation system has been implemented to assimilate real chlorophyll data from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS into a three-dimensional biochemical model of the Eastern Mediterranean. The physical ocean is described through the Princeton Ocean Model (POM while the biochemistry of the ecosystem is tackled with the Biochemical Flux Model (BFM. The assimilation scheme is based on the Singular Evolutive Extended Kalman (SEEK filter, in which the error statistics were parameterized by means of a suitable set of Empirical Orthogonal Functions (EOFs. A radius of influence was further selected around every data point to limit the range of the EOFs spatial correlations. The assimilation experiment was performed for one year over 1999 and forced with ECMWF 6 hour atmospheric fields. The accuracy of the ecological state identification by the assimilation system is assessed by the relevance of the system in fitting the data, and through the impact of the assimilation on non-observed biochemical processes. Assimilation of SeaWiFS data significantly improves the forecasting capability of the BFM model. Results, however, indicate the necessity of subsurface data to enhance the controllability of the ecosystem model in the deep layers.

  10. Information Network Model Query Processing

    Science.gov (United States)

    Song, Xiaopu

    Information Networking Model (INM) [31] is a novel database model for real world objects and relationships management. It naturally and directly supports various kinds of static and dynamic relationships between objects. In INM, objects are networked through various natural and complex relationships. INM Query Language (INM-QL) [30] is designed to explore such information network, retrieve information about schema, instance, their attributes, relationships, and context-dependent information, and process query results in the user specified form. INM database management system has been implemented using Berkeley DB, and it supports INM-QL. This thesis is mainly focused on the implementation of the subsystem that is able to effectively and efficiently process INM-QL. The subsystem provides a lexical and syntactical analyzer of INM-QL, and it is able to choose appropriate evaluation strategies and index mechanism to process queries in INM-QL without the user's intervention. It also uses intermediate result structure to hold intermediate query result and other helping structures to reduce complexity of query processing.

  11. Multilayer weighted social network model

    Science.gov (United States)

    Murase, Yohsuke; Török, János; Jo, Hang-Hyun; Kaski, Kimmo; Kertész, János

    2014-11-01

    Recent empirical studies using large-scale data sets have validated the Granovetter hypothesis on the structure of the society in that there are strongly wired communities connected by weak ties. However, as interaction between individuals takes place in diverse contexts, these communities turn out to be overlapping. This implies that the society has a multilayered structure, where the layers represent the different contexts. To model this structure we begin with a single-layer weighted social network (WSN) model showing the Granovetterian structure. We find that when merging such WSN models, a sufficient amount of interlayer correlation is needed to maintain the relationship between topology and link weights, while these correlations destroy the enhancement in the community overlap due to multiple layers. To resolve this, we devise a geographic multilayer WSN model, where the indirect interlayer correlations due to the geographic constraints of individuals enhance the overlaps between the communities and, at the same time, the Granovetterian structure is preserved.

  12. Brand Marketing Model on Social Networks

    OpenAIRE

    Jolita Jezukevičiūtė; Vida Davidavičienė

    2014-01-01

    The paper analyzes the brand and its marketing solutions onsocial networks. This analysis led to the creation of improvedbrand marketing model on social networks, which will contributeto the rapid and cheap organization brand recognition, increasecompetitive advantage and enhance consumer loyalty. Therefore,the brand and a variety of social networks are becoming a hotresearch area for brand marketing model on social networks.The world‘s most successful brand marketing models exploratoryanalys...

  13. Network Bandwidth Utilization Forecast Model on High Bandwidth Network

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Wucherl; Sim, Alex

    2014-07-07

    With the increasing number of geographically distributed scientific collaborations and the scale of the data size growth, it has become more challenging for users to achieve the best possible network performance on a shared network. We have developed a forecast model to predict expected bandwidth utilization for high-bandwidth wide area network. The forecast model can improve the efficiency of resource utilization and scheduling data movements on high-bandwidth network to accommodate ever increasing data volume for large-scale scientific data applications. Univariate model is developed with STL and ARIMA on SNMP path utilization data. Compared with traditional approach such as Box-Jenkins methodology, our forecast model reduces computation time by 83.2percent. It also shows resilience against abrupt network usage change. The accuracy of the forecast model is within the standard deviation of the monitored measurements.

  14. Modified Step Variational Iteration Method for Solving Fractional Biochemical Reaction Model

    Directory of Open Access Journals (Sweden)

    R. Yulita Molliq

    2011-01-01

    Full Text Available A new method called the modification of step variational iteration method (MoSVIM is introduced and used to solve the fractional biochemical reaction model. The MoSVIM uses general Lagrange multipliers for construction of the correction functional for the problems, and it runs by step approach, which is to divide the interval into subintervals with time step, and the solutions are obtained at each subinterval as well adopting a nonzero auxiliary parameter ℏ to control the convergence region of series' solutions. The MoSVIM yields an analytical solution of a rapidly convergent infinite power series with easily computable terms and produces a good approximate solution on enlarged intervals for solving the fractional biochemical reaction model. The accuracy of the results obtained is in a excellent agreement with the Adam Bashforth Moulton method (ABMM.

  15. Modelling of Mass Transfer Phenomena in Chemical and Biochemical Reactor Systems using Computational Fluid Dynamics

    DEFF Research Database (Denmark)

    Larsson, Hilde Kristina

    , mixing, and other mass transfer phenomena in chemical and biochemical reactor systems. In this project, four selected case studies are investigated in order to explore the capabilities of CFD. The selected cases are a 1 ml stirred microbioreactor, an 8 ml magnetically stirred reactor, a Rushton impeller...... in chemical and biochemical reactors but that the user must be well aware of the shortcomings with the applied models....... the velocity and pressure distributions in a fluid. CFD also enables the modelling of several fluids simultaneously, e.g. gas bubbles in a liquid, as well as the presence of turbulence and dissolved chemicals in a fluid, and many other phenomena. This makes CFD an appreciated tool for studying flow structures...

  16. Distributed Combat System of Systems Network Modeling

    Directory of Open Access Journals (Sweden)

    Yanbo Qi

    2013-08-01

    Full Text Available How to generate the topology model of Distributed combat System of Systems network is an important issue in combat analysis. A combat network construction algorithm was proposed to solve the problem. The improved hierarchy network evolving method was used to construct the command and control network, and the combat network generation algorithm was developed by the growth and local priority connections of new node joining into the command network. And then the analytical expression of the degree distribution of the network model was deduced via the mean-field theory method. Finally, the network model was analyzed according to the topology statistical parameters. The analyzing results show that under the same command span, though the command network topology doesn’t change when command level was increased, but the topology performance of the combat network is improved. This is in line with actual combat network; the comparison of degree distribution of analytical results and simulation results indicated that the degree distribution of network model we proposed follows a power law distribution, with exponential value depending on the initial number of command and control network and the number of nodes connected to the rest of the network , verifying the validity of the algorithm model.

  17. Gray box modeling of MSW degradation: Revealing its dominant (bio)chemical mechanism

    OpenAIRE

    Van Turnhout, A.G.; Heimovaara, T.J.; Kleerebezem, R.

    2013-01-01

    In this paper we present an approach to describe organic degradation within immobile water regions of Municipal Solid Waste (MSW) landfills which is best described by the term “gray box” model. We use a simplified set of dominant (bio)chemical and physical reactions and realistic environmental conditions. All equations, relationships and inhibitions are based on semi-empirical or fundamental relationships which have proven to be applicable in the peer reviewed literature. As much as possible ...

  18. Analysis by fracture network modelling

    International Nuclear Information System (INIS)

    This report describes the Fracture Network Modelling and Performance Assessment Support performed by Golder Associates Inc. during the Heisei-11 (1999-2000) fiscal year. The primary objective of the Golder Associates work scope during HY-11 was to provide theoretical and review support to the JNC HY-12 Performance assessment effort. In addition, Golder Associates provided technical support to JNC for the Aespoe Project. Major efforts for performance assessment support included analysis of PAWorks pathways and software documentation, verification, and performance assessment visualization. Support for the Aespoe project including 'Task 4' predictive modelling of sorbing tracer transport in TRUE-1 rock block, and integrated hydrogeological and geochemical modelling of Aespoe island for 'Task 5'. Technical information about Golder Associates HY-11 support to JNC is provided in the appendices to this report. (author)

  19. Modelling delay propagation within an airport network

    NARCIS (Netherlands)

    Pyrgiotis, N.; Malone, K.M.; Odoni, A.

    2013-01-01

    We describe an analytical queuing and network decomposition model developed to study the complex phenomenon of the propagation of delays within a large network of major airports. The Approximate Network Delays (AND) model computes the delays due to local congestion at individual airports and capture

  20. An acoustical model based monitoring network

    NARCIS (Netherlands)

    Wessels, P.W.; Basten, T.G.H.; Eerden, F.J.M. van der

    2010-01-01

    In this paper the approach for an acoustical model based monitoring network is demonstrated. This network is capable of reconstructing a noise map, based on the combination of measured sound levels and an acoustic model of the area. By pre-calculating the sound attenuation within the network the noi

  1. Eight challenges for network epidemic models

    Directory of Open Access Journals (Sweden)

    Lorenzo Pellis

    2015-03-01

    Full Text Available Networks offer a fertile framework for studying the spread of infection in human and animal populations. However, owing to the inherent high-dimensionality of networks themselves, modelling transmission through networks is mathematically and computationally challenging. Even the simplest network epidemic models present unanswered questions. Attempts to improve the practical usefulness of network models by including realistic features of contact networks and of host–pathogen biology (e.g. waning immunity have made some progress, but robust analytical results remain scarce. A more general theory is needed to understand the impact of network structure on the dynamics and control of infection. Here we identify a set of challenges that provide scope for active research in the field of network epidemic models.

  2. Modeling the relationships between quality and biochemical composition of fatty liver in mule ducks.

    Science.gov (United States)

    Theron, L; Cullere, M; Bouillier-Oudot, M; Manse, H; Dalle Zotte, A; Molette, C; Fernandez, X; Vitezica, Z G

    2012-09-01

    The fatty liver of mule ducks (i.e., French "foie gras") is the most valuable product in duck production systems. Its quality is measured by the technological yield, which is the opposite of the fat loss during cooking. The purpose of this study was to determine whether biochemical measures of fatty liver could be used to accurately predict the technological yield (TY). Ninety-one male mule ducks were bred, overfed, and slaughtered under commercial conditions. Fatty liver weight (FLW) and biochemical variables, such as DM, lipid (LIP), and protein content (PROT), were collected. To evaluate evidence for nonlinear fat loss during cooking, we compared regression models describing linear and nonlinear relations between biochemical measures and TY. We detected significantly greater (P = 0.02) linear relation between DM and TY. Our results indicate that LIP and PROT follow a different pattern (linear) than DM and showed that LIP and PROT are nonexclusive contributing factors to TY. Other components, such as carbohydrates, other than those measured in this study, could contribute to DM. Stepwise regression for TY was performed. The traditional model with FLW was tested. The results showed that the weight of the liver is of limited value in the determination of fat loss during cooking (R(2) = 0.14). The most accurate TY prediction equation included DM (in linear and quadratic terms), FLW, and PROT (R(2) = 0.43). Biochemical measures in the fatty liver were more accurate predictors of TY than FLW. The model is useful in commercial conditions because DM, PROT, and FLW are noninvasive measures.

  3. An evolutionary model of social networks

    Science.gov (United States)

    Ludwig, M.; Abell, P.

    2007-07-01

    Social networks in communities, markets, and societies self-organise through the interactions of many individuals. In this paper we use a well-known mechanism of social interactions — the balance of sentiment in triadic relations — to describe the development of social networks. Our model contrasts with many existing network models, in that people not only establish but also break up relations whilst the network evolves. The procedure generates several interesting network features such as a variety of degree distributions and degree correlations. The resulting network converges under certain conditions to a steady critical state where temporal disruptions in triangles follow a power-law distribution.

  4. Modeling Diagnostic Assessments with Bayesian Networks

    Science.gov (United States)

    Almond, Russell G.; DiBello, Louis V.; Moulder, Brad; Zapata-Rivera, Juan-Diego

    2007-01-01

    This paper defines Bayesian network models and examines their applications to IRT-based cognitive diagnostic modeling. These models are especially suited to building inference engines designed to be synchronous with the finer grained student models that arise in skills diagnostic assessment. Aspects of the theory and use of Bayesian network models…

  5. Multiplexing oscillatory biochemical signals.

    Science.gov (United States)

    de Ronde, Wiet; ten Wolde, Pieter Rein

    2014-04-01

    In recent years it has been increasingly recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier. Moreover, it is now well established that the protein signaling network of living cells has a bow-tie structure and that components are often shared between different signaling pathways. Here we show by mathematical modeling that living cells can multiplex a constant and an oscillatory signal: they can transmit these two signals simultaneously through a common signaling pathway, and yet respond to them specifically and reliably. We find that information transmission is reduced not only by noise arising from the intrinsic stochasticity of biochemical reactions, but also by crosstalk between the different channels. Yet, under biologically relevant conditions more than 2 bits of information can be transmitted per channel, even when the two signals are transmitted simultaneously. These observations suggest that oscillatory signals are ideal for multiplexing signals. PMID:24685537

  6. Graph Annotations in Modeling Complex Network Topologies

    CERN Document Server

    Dimitropoulos, Xenofontas; Vahdat, Amin; Riley, George

    2007-01-01

    The coarsest approximation of the structure of a complex network, such as the Internet, is a simple undirected unweighted graph. This approximation, however, loses too much detail. In reality, objects represented by vertices and edges in such a graph possess some non-trivial internal structure that varies across and differentiates among distinct types of links or nodes. In this work, we abstract such additional information as network annotations. We introduce a network topology modeling framework that treats annotations as an extended correlation profile of a network. Assuming we have this profile measured for a given network, we present an algorithm to rescale it in order to construct networks of varying size that still reproduce the original measured annotation profile. Using this methodology, we accurately capture the network properties essential for realistic simulations of network applications and protocols, or any other simulations involving complex network topologies, including modeling and simulation ...

  7. A Computational Model of Cell Migration in Response to Biochemical Diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Dexter, Nicholas C [ORNL; Kruse, Kara L [ORNL; Nutaro, James J [ORNL; Ward, Richard C [ORNL

    2009-01-01

    The Computational Sciences and Engineering Division of the Oak Ridge National Laboratory is partnering with the University of Tennessee Graduate School of Medicine to design a computational model describing various factors related to the development of intimal hyperplasia (IH) in response to arterial injury. This research focuses on modeling the chemotactic and haptotactic processes that stimulate vascular smooth muscle cell migration into the intima. A hybrid discrete-continuous mathematical model of cell migration in response to biochemical diffusion was developed in C++. Chemoattractant diffusion is modeled as a continuous partial differential equation, whereas migration of the cells is modeled as a series of discrete events. Results obtained from the discrete state model for cell migration agree with those obtained from Boyden chamber experiments.

  8. How to model wireless mesh networks topology

    International Nuclear Information System (INIS)

    The specification of network connectivity model or topology is the beginning of design and analysis in Computer Network researches. Wireless Mesh Networks is an autonomic network that is dynamically self-organised, self-configured while the mesh nodes establish automatic connectivity with the adjacent nodes in the relay network of wireless backbone routers. Researches in Wireless Mesh Networks range from node deployment to internetworking issues with sensor, Internet and cellular networks. These researches require modelling of relationships and interactions among nodes including technical characteristics of the links while satisfying the architectural requirements of the physical network. However, the existing topology generators model geographic topologies which constitute different architectures, thus may not be suitable in Wireless Mesh Networks scenarios. The existing methods of topology generation are explored, analysed and parameters for their characterisation are identified. Furthermore, an algorithm for the design of Wireless Mesh Networks topology based on square grid model is proposed in this paper. The performance of the topology generated is also evaluated. This research is particularly important in the generation of a close-to-real topology for ensuring relevance of design to the intended network and validity of results obtained in Wireless Mesh Networks researches

  9. Model Of Neural Network With Creative Dynamics

    Science.gov (United States)

    Zak, Michail; Barhen, Jacob

    1993-01-01

    Paper presents analysis of mathematical model of one-neuron/one-synapse neural network featuring coupled activation and learning dynamics and parametrical periodic excitation. Demonstrates self-programming, partly random behavior of suitable designed neural network; believed to be related to spontaneity and creativity of biological neural networks.

  10. Magneto-electric network models in electromagnetism

    OpenAIRE

    Demenko, A.; Sykulski, J. K.

    2006-01-01

    Purpose – The aim of this paper is to develop network models of an electromagnetic field containing both eddy and displacement currents. The proposed network models provide good physical insight, help understanding of complicated electromagnetic phenomena and aid explanation of methods of analysis of electromagnetic systems. Design/methodology/approach – The models consist of magnetic and electric networks coupled via sources. The analogy between the finite element method and the loop and nod...

  11. CIMS Network Protocol and Its Net Models

    Institute of Scientific and Technical Information of China (English)

    罗军舟; 顾冠群

    1997-01-01

    Computer communication network architectures for cims are based on the OSI Reference Model.In this paper,CIMS network protocol model is set up on the basis of the corresqonding service model.Then the authors present a formal specification of transport protocols by using an extended Predicate/Transition net system that is briefly introduced in the third part.Finally,the general methods for the Petri nets based formal specification of CIMS network protocols are outlined.

  12. Agent-based modeling and network dynamics

    CERN Document Server

    Namatame, Akira

    2016-01-01

    The book integrates agent-based modeling and network science. It is divided into three parts, namely, foundations, primary dynamics on and of social networks, and applications. The book begins with the network origin of agent-based models, known as cellular automata, and introduce a number of classic models, such as Schelling’s segregation model and Axelrod’s spatial game. The essence of the foundation part is the network-based agent-based models in which agents follow network-based decision rules. Under the influence of the substantial progress in network science in late 1990s, these models have been extended from using lattices into using small-world networks, scale-free networks, etc. The book also shows that the modern network science mainly driven by game-theorists and sociophysicists has inspired agent-based social scientists to develop alternative formation algorithms, known as agent-based social networks. The book reviews a number of pioneering and representative models in this family. Upon the gi...

  13. Localized Modeling of Biochemical and Flow Interactions during Cancer Cell Adhesion.

    Directory of Open Access Journals (Sweden)

    Julie Behr

    Full Text Available This work focuses on one component of a larger research effort to develop a simulation tool to model populations of flowing cells. Specifically, in this study a local model of the biochemical interactions between circulating melanoma tumor cells (TC and substrate adherent polymorphonuclear neutrophils (PMN is developed. This model provides realistic three-dimensional distributions of bond formation and attendant attraction and repulsion forces that are consistent with the time dependent Computational Fluid Dynamics (CFD framework of the full system model which accounts local pressure, shear and repulsion forces. The resulting full dynamics model enables exploration of TC adhesion to adherent PMNs, which is a known participating mechanism in melanoma cell metastasis. The model defines the adhesion molecules present on the TC and PMN cell surfaces, and calculates their interactions as the melanoma cell flows past the PMN. Biochemical rates of reactions between individual molecules are determined based on their local properties. The melanoma cell in the model expresses ICAM-1 molecules on its surface, and the PMN expresses the β-2 integrins LFA-1 and Mac-1. In this work the PMN is fixed to the substrate and is assumed fully rigid and of a prescribed shear-rate dependent shape obtained from micro-PIV experiments. The melanoma cell is transported with full six-degrees-of-freedom dynamics. Adhesion models, which represent the ability of molecules to bond and adhere the cells to each other, and repulsion models, which represent the various physical mechanisms of cellular repulsion, are incorporated with the CFD solver. All models are general enough to allow for future extensions, including arbitrary adhesion molecule types, and the ability to redefine the values of parameters to represent various cell types. The model presented in this study will be part of a clinical tool for development of personalized medical treatment programs.

  14. Edge exchangeable models for network data

    CERN Document Server

    Crane, Harry

    2016-01-01

    Exchangeable models for vertex labeled graphs cannot replicate the large sample behaviors of sparsity and power law degree distributions observed in many network datasets. Out of this mathematical impossibility emerges the question of how network data can be modeled in a way that reflects known empirical behaviors and respects basic statistical principles. We address this question by observing that edges, not vertices, act as the statistical units in most network datasets, making a theory of edge labeled networks more natural for most applications. Within this context we introduce the new invariance principle of {\\em edge exchangeability}, which unlike its vertex exchangeable counterpart can produce networks with sparse and/or power law structure. We characterize the class of all edge exchangeable network models and identify a particular two parameter family of models with suitable theoretical properties for statistical inference. We discuss issues of estimation from edge exchangeable models and compare our a...

  15. Modeling Network Evolution Using Graph Motifs

    CERN Document Server

    Conway, Drew

    2011-01-01

    Network structures are extremely important to the study of political science. Much of the data in its subfields are naturally represented as networks. This includes trade, diplomatic and conflict relationships. The social structure of several organization is also of interest to many researchers, such as the affiliations of legislators or the relationships among terrorist. A key aspect of studying social networks is understanding the evolutionary dynamics and the mechanism by which these structures grow and change over time. While current methods are well suited to describe static features of networks, they are less capable of specifying models of change and simulating network evolution. In the following paper I present a new method for modeling network growth and evolution. This method relies on graph motifs to generate simulated network data with particular structural characteristic. This technique departs notably from current methods both in form and function. Rather than a closed-form model, or stochastic ...

  16. Modeling data throughput on communication networks

    Energy Technology Data Exchange (ETDEWEB)

    Eldridge, J.M.

    1993-11-01

    New challenges in high performance computing and communications are driving the need for fast, geographically distributed networks. Applications such as modeling physical phenomena, interactive visualization, large data set transfers, and distributed supercomputing require high performance networking [St89][Ra92][Ca92]. One measure of a communication network`s performance is the time it takes to complete a task -- such as transferring a data file or displaying a graphics image on a remote monitor. Throughput, defined as the ratio of the number of useful data bits transmitted per the time required to transmit those bits, is a useful gauge of how well a communication system meets this performance measure. This paper develops and describes an analytical model of throughput. The model is a tool network designers can use to predict network throughput. It also provides insight into those parts of the network that act as a performance bottleneck.

  17. Queuing theory models for computer networks

    Science.gov (United States)

    Galant, David C.

    1989-01-01

    A set of simple queuing theory models which can model the average response of a network of computers to a given traffic load has been implemented using a spreadsheet. The impact of variations in traffic patterns and intensities, channel capacities, and message protocols can be assessed using them because of the lack of fine detail in the network traffic rates, traffic patterns, and the hardware used to implement the networks. A sample use of the models applied to a realistic problem is included in appendix A. Appendix B provides a glossary of terms used in this paper. This Ames Research Center computer communication network is an evolving network of local area networks (LANs) connected via gateways and high-speed backbone communication channels. Intelligent planning of expansion and improvement requires understanding the behavior of the individual LANs as well as the collection of networks as a whole.

  18. A Conceptual Model of Learning Networks

    Science.gov (United States)

    Koper, Rob

    In the TENCompetence project a set of UML models (Booch et al. 1999) have been developed to specify the core concepts for Learning Networks Services that support professional competence development. The three most important, high-level models are (a) the use case model, (b) the conceptual model, and (c) the domain model. The first model identifies the primary use cases we need in order to support professional competence development. The second model describes the concept of competence and competence development from a theoretical point of view. What is a competence? How does it relate to the cognitive system of an actor? How are competences developed? The third model is a UML Domain Model that defines, among other things, the components of a Learning Network, defines the concepts and relationships between the concepts in a Learning Network and provides a starting point for the design of the overall architecture for Learning Network Services, including the data model.

  19. Landauer in the Age of Synthetic Biology: Energy Consumption and Information Processing in Biochemical Networks

    Science.gov (United States)

    Mehta, Pankaj; Lang, Alex H.; Schwab, David J.

    2016-03-01

    A central goal of synthetic biology is to design sophisticated synthetic cellular circuits that can perform complex computations and information processing tasks in response to specific inputs. The tremendous advances in our ability to understand and manipulate cellular information processing networks raises several fundamental physics questions: How do the molecular components of cellular circuits exploit energy consumption to improve information processing? Can one utilize ideas from thermodynamics to improve the design of synthetic cellular circuits and modules? Here, we summarize recent theoretical work addressing these questions. Energy consumption in cellular circuits serves five basic purposes: (1) increasing specificity, (2) manipulating dynamics, (3) reducing variability, (4) amplifying signal, and (5) erasing memory. We demonstrate these ideas using several simple examples and discuss the implications of these theoretical ideas for the emerging field of synthetic biology. We conclude by discussing how it may be possible to overcome these limitations using "post-translational" synthetic biology that exploits reversible protein modification.

  20. Noise transmission and delay-induced stochasticoscillations in biochemical network motifs

    Institute of Scientific and Technical Information of China (English)

    Liu Sheng-Jun; Wang Qi; Liu Bo; Yan Shi-Wei; Fumihiko Sakata

    2011-01-01

    With the aid of stochastic delayed-feedback differential equations,we derive an analytic expression for the power spectra of reacting molecules included in a generic biological network motif that is incorporated with a feedback mechanism and time delays in gene regulation.We systematically analyse the effects of time delays,the feedback mechanism,and biological stochasticity on the power spectra.It has been clarified that the time delays together with the feedback mechanism can induce stochastic oscillations at the molecular level and invalidate the noise addition rule for a modular description of the noise propagator.Delay-induced stochastic resonance can be expected,which is related to the stability loss of the reaction systems and Hopf bifurcation occurring for solutions of the corresponding deterministic reaction equations.Through the analysis of the power spectrum,a new approach is proposed to estimate the oscillation period.

  1. Random graph models for dynamic networks

    CERN Document Server

    Zhang, Xiao; Newman, M E J

    2016-01-01

    We propose generalizations of a number of standard network models, including the classic random graph, the configuration model, and the stochastic block model, to the case of time-varying networks. We assume that the presence and absence of edges are governed by continuous-time Markov processes with rate parameters that can depend on properties of the nodes. In addition to computing equilibrium properties of these models, we demonstrate their use in data analysis and statistical inference, giving efficient algorithms for fitting them to observed network data. This allows us, for instance, to estimate the time constants of network evolution or infer community structure from temporal network data using cues embedded both in the probabilities over time that node pairs are connected by edges and in the characteristic dynamics of edge appearance and disappearance. We illustrate our methods with a selection of applications, both to computer-generated test networks and real-world examples.

  2. Exponential-family Random Network Models

    OpenAIRE

    Fellows, I; Handcock, MS

    2012-01-01

    Random graphs, where the connections between nodes are considered random variables, have wide applicability in the social sciences. Exponential-family Random Graph Models (ERGM) have shown themselves to be a useful class of models for representing com- plex social phenomena. We generalize ERGM by also modeling nodal attributes as random variates, thus creating a random model of the full network, which we call Exponential-family Random Network Models (ERNM). We demonstrate how this framework a...

  3. Modelling the structure of complex networks

    DEFF Research Database (Denmark)

    Herlau, Tue

    networks has been independently studied as mathematical objects in their own right. As such, there has been both an increased demand for statistical methods for complex networks as well as a quickly growing mathematical literature on the subject. In this dissertation we explore aspects of modelling complex....... The next chapters will treat some of the various symmetries, representer theorems and probabilistic structures often deployed in the modelling complex networks, the construction of sampling methods and various network models. The introductory chapters will serve to provide context for the included written...

  4. Monochromaticity in Neutral Evolutionary Network Models

    OpenAIRE

    Halu, Arda; Bianconi, Ginestra

    2012-01-01

    Recent studies on epistatic networks of model organisms have unveiled a certain type of modular property called monochromaticity in which the networks are clusterable into functional modules that interact with each other through the same type of epistasis. Here we propose and study three epistatic network models that are inspired by the Duplication-Divergence mechanism to gain insight into the evolutionary basis of monochromaticity and to test if it can be explained as the outcome of a neutra...

  5. Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score

    Directory of Open Access Journals (Sweden)

    Xin-Hai Hu

    2014-12-01

    Full Text Available Many computer models for predicting the risk of prostate cancer have been developed including for prediction of biochemical recurrence (BCR. However, models for individual BCR free probability at individual time-points after a BCR free period are rare. Follow-up data from 1656 patients who underwent laparoscopic radical prostatectomy (LRP were used to develop an artificial neural network (ANN to predict BCR and to compare it with a logistic regression (LR model using clinical and pathologic parameters, prostate-specific antigen (PSA, margin status (R0/1, pathological stage (pT, and Gleason Score (GS. For individual BCR prediction at any given time after operation, additional ANN, and LR models were calculated every 6 months for up to 7.5 years of follow-up. The areas under the receiver operating characteristic (ROC curve (AUC for the ANN (0.754 and LR models (0.755 calculated immediately following LRP, were larger than that for GS (AUC: 0.715; P = 0.0015 and 0.001, pT or PSA (AUC: 0.619; P always <0.0001 alone. The GS predicted the BCR better than PSA (P = 0.0001, but there was no difference between the ANN and LR models (P = 0.39. Our ANN and LR models predicted individual BCR risk from radical prostatectomy for up to 10 years postoperative. ANN and LR models equally and significantly improved the prediction of BCR compared with PSA and GS alone. When the GS and ANN output values are combined, a more accurate BCR prediction is possible, especially in high-risk patients with GS ≥7.

  6. Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score.

    Science.gov (United States)

    Hu, Xin-Hai; Cammann, Henning; Meyer, Hellmuth-A; Jung, Klaus; Lu, Hong-Biao; Leva, Natalia; Magheli, Ahmed; Stephan, Carsten; Busch, Jonas

    2014-01-01

    Many computer models for predicting the risk of prostate cancer have been developed including for prediction of biochemical recurrence (BCR). However, models for individual BCR free probability at individual time-points after a BCR free period are rare. Follow-up data from 1656 patients who underwent laparoscopic radical prostatectomy (LRP) were used to develop an artificial neural network (ANN) to predict BCR and to compare it with a logistic regression (LR) model using clinical and pathologic parameters, prostate-specific antigen (PSA), margin status (R0/1), pathological stage (pT), and Gleason Score (GS). For individual BCR prediction at any given time after operation, additional ANN, and LR models were calculated every 6 months for up to 7.5 years of follow-up. The areas under the receiver operating characteristic (ROC) curve (AUC) for the ANN (0.754) and LR models (0.755) calculated immediately following LRP, were larger than that for GS (AUC: 0.715; P = 0.0015 and 0.001), pT or PSA (AUC: 0.619; P always <0.0001) alone. The GS predicted the BCR better than PSA (P = 0.0001), but there was no difference between the ANN and LR models (P = 0.39). Our ANN and LR models predicted individual BCR risk from radical prostatectomy for up to 10 years postoperative. ANN and LR models equally and significantly improved the prediction of BCR compared with PSA and GS alone. When the GS and ANN output values are combined, a more accurate BCR prediction is possible, especially in high-risk patients with GS ≥7. PMID:25130472

  7. Nonconsensus opinion model on directed networks

    NARCIS (Netherlands)

    Qu, B.; Li, Q.; Havlin, S.; Stanley, E.; Wang, H.

    2014-01-01

    Dynamic social opinion models have been widely studied on undirected networks, and most of them are based on spin interaction models that produce a consensus. In reality, however, many networks such as Twitter and the World Wide Web are directed and are composed of both unidirectional and bidirectio

  8. Different biochemical mechanisms ensure network-wide balancing of reducing equivalents in microbial metabolism.

    Science.gov (United States)

    Fuhrer, Tobias; Sauer, Uwe

    2009-04-01

    To sustain growth, the catabolic formation of the redox equivalent NADPH must be balanced with the anabolic demand. The mechanisms that ensure such network-wide balancing, however, are presently not understood. Based on 13C-detected intracellular fluxes, metabolite concentrations, and cofactor specificities for all relevant central metabolic enzymes, we have quantified catabolic NADPH production in Agrobacterium tumefaciens, Bacillus subtilis, Escherichia coli, Paracoccus versutus, Pseudomonas fluorescens, Rhodobacter sphaeroides, Sinorhizobium meliloti, and Zymomonas mobilis. For six species, the estimated NADPH production from glucose catabolism exceeded the requirements for biomass synthesis. Exceptions were P. fluorescens, with balanced rates, and E. coli, with insufficient catabolic production, in which about one-third of the NADPH is supplied via the membrane-bound transhydrogenase PntAB. P. versutus and B. subtilis were the only species that appear to rely on transhydrogenases for balancing NADPH overproduction during growth on glucose. In the other four species, the main but not exclusive redox-balancing mechanism appears to be the dual cofactor specificities of several catabolic enzymes and/or the existence of isoenzymes with distinct cofactor specificities, in particular glucose 6-phosphate dehydrogenase. An unexpected key finding for all species, except E. coli and B. subtilis, was the lack of cofactor specificity in the oxidative pentose phosphate pathway, which contrasts with the textbook view of the pentose phosphate pathway dehydrogenases as being NADP+ dependent.

  9. Performance modeling of network data services

    Energy Technology Data Exchange (ETDEWEB)

    Haynes, R.A.; Pierson, L.G.

    1997-01-01

    Networks at major computational organizations are becoming increasingly complex. The introduction of large massively parallel computers and supercomputers with gigabyte memories are requiring greater and greater bandwidth for network data transfers to widely dispersed clients. For networks to provide adequate data transfer services to high performance computers and remote users connected to them, the networking components must be optimized from a combination of internal and external performance criteria. This paper describes research done at Sandia National Laboratories to model network data services and to visualize the flow of data from source to sink when using the data services.

  10. Unified Hybrid Network Theoretical Model Trilogy

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The first of the unified hybrid network theoretical model trilogy (UHNTF) is the harmonious unification hybrid preferential model (HUHPM), seen in the inner loop of Fig. 1, the unified hybrid ratio is defined.

  11. Network models in economics and finance

    CERN Document Server

    Pardalos, Panos; Rassias, Themistocles

    2014-01-01

    Using network models to investigate the interconnectivity in modern economic systems allows researchers to better understand and explain some economic phenomena. This volume presents contributions by known experts and active researchers in economic and financial network modeling. Readers are provided with an understanding of the latest advances in network analysis as applied to economics, finance, corporate governance, and investments. Moreover, recent advances in market network analysis  that focus on influential techniques for market graph analysis are also examined. Young researchers will find this volume particularly useful in facilitating their introduction to this new and fascinating field. Professionals in economics, financial management, various technologies, and network analysis, will find the network models presented in this book beneficial in analyzing the interconnectivity in modern economic systems.

  12. Incorporation of leaf nitrogen observations for biochemical and environmental modeling of photosynthesis and evapotranspiration

    DEFF Research Database (Denmark)

    Boegh, E; Gjetterman, B; Abrahamsen, P;

    2007-01-01

    relation to photosynthetic (Rubisco) capacity should also be known to quantify leaf N impacts on canopy photosynthesis. In this study, impacts of the amount and vertical distribution of leaf N contents on canopy photosynthesis were investigated by combining field measurements and photosynthesis modelling....... While most canopy photosynthesis models assume an exponential vertical profile of leaf N contents in the canopy, the field measurements showed that well-fertilized fields may have a uniform or exponential profile, and senescent canopies have reduced levels of N contents in upper leaves. The sensitivity...... of simulated canopy photosynthesis to the different (observed) N profiles was examined using a multi-layer sun/shade biochemically based photosynthesis model and found to be important; ie. for a well-fertilized barley field, the use of exponential instead of uniform vertical N profiles increased the annual...

  13. [Simulation of vegetation indices optimizing under retrieval of vegetation biochemical parameters based on PROSPECT + SAIL model].

    Science.gov (United States)

    Wu, Ling; Liu, Xiang-Nan; Zhou, Bo-Tian; Liu, Chuan-Hao; Li, Lu-Feng

    2012-12-01

    This study analyzed the sensitivities of three vegetation biochemical parameters [chlorophyll content (Cab), leaf water content (Cw), and leaf area index (LAI)] to the changes of canopy reflectance, with the effects of each parameter on the wavelength regions of canopy reflectance considered, and selected three vegetation indices as the optimization comparison targets of cost function. Then, the Cab, Cw, and LAI were estimated, based on the particle swarm optimization algorithm and PROSPECT + SAIL model. The results showed that retrieval efficiency with vegetation indices as the optimization comparison targets of cost function was better than that with all spectral reflectance. The correlation coefficients (R2) between the measured and estimated values of Cab, Cw, and LAI were 90.8%, 95.7%, and 99.7%, and the root mean square errors of Cab, Cw, and LAI were 4.73 microg x cm(-2), 0.001 g x cm(-2), and 0.08, respectively. It was suggested that to adopt vegetation indices as the optimization comparison targets of cost function could effectively improve the efficiency and precision of the retrieval of biochemical parameters based on PROSPECT + SAIL model.

  14. A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase.

    Science.gov (United States)

    Senkevitch, Emilee; Cabrera-Luque, Juan; Morizono, Hiroki; Caldovic, Ljubica; Tuchman, Mendel

    2012-06-01

    All knockout mouse models of urea cycle disorders die in the neonatal period or shortly thereafter. Since N-acetylglutamate synthase (NAGS) deficiency in humans can be effectively treated with N-carbamyl-l-glutamate (NCG), we sought to develop a mouse model of this disorder that could be rescued by biochemical intervention, reared to adulthood, reproduce, and become a novel animal model for hyperammonemia. Founder NAGS knockout heterozygous mice were obtained from the trans-NIH Knock-Out Mouse Project. Genotyping of the mice was performed by PCR and confirmed by Western blotting of liver and intestine. NCG and L-citrulline (Cit) were used to rescue the NAGS knockout homozygous (Nags(-/-)) pups and the rescued animals were characterized. We observed an 85% survival rate of Nags(-/-) mice when they were given intraperitoneal injections with NCG and Cit during the newborn period until weaning and supplemented subsequently with both compounds in their drinking water. This regimen has allowed for normal development, apparent health, and reproduction. Interruption of this rescue intervention resulted in the development of severe hyperammonemia and death within 48 h. In addition to hyperammonemia, interruption of rescue supplementation was associated with elevated plasma glutamine, glutamate, and lysine, and reduced citrulline, arginine, ornithine and proline levels. We conclude that NAGS deprived mouse model has been developed which can be rescued by NCG and Cit and reared to reproduction and beyond. This biochemically salvageable mouse model recapitulates the clinical phenotype of proximal urea cycle disorders and can be used as a reliable model of induced hyperammonemia by manipulating the administration of the rescue compounds. PMID:22503289

  15. Strategic games on a hierarchical network model

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Among complex network models, the hierarchical network model is the one most close to such real networks as world trade web, metabolic network, WWW, actor network, and so on. It has not only the property of power-law degree distribution, but growth based on growth and preferential attachment, showing the scale-free degree distribution property. In this paper, we study the evolution of cooperation on a hierarchical network model, adopting the prisoner's dilemma (PD) game and snowdrift game (SG) as metaphors of the interplay between connected nodes. BA model provides a unifying framework for the emergence of cooperation. But interestingly, we found that on hierarchical model, there is no sign of cooperation for PD game, while the frequency of cooperation decreases as the common benefit decreases for SG. By comparing the scaling clustering coefficient properties of the hierarchical network model with that of BA model, we found that the former amplifies the effect of hubs. Considering different performances of PD game and SG on complex network, we also found that common benefit leads to cooperation in the evolution. Thus our study may shed light on the emergence of cooperation in both natural and social environments.

  16. Towards reproducible descriptions of neuronal network models.

    Directory of Open Access Journals (Sweden)

    Eilen Nordlie

    2009-08-01

    Full Text Available Progress in science depends on the effective exchange of ideas among scientists. New ideas can be assessed and criticized in a meaningful manner only if they are formulated precisely. This applies to simulation studies as well as to experiments and theories. But after more than 50 years of neuronal network simulations, we still lack a clear and common understanding of the role of computational models in neuroscience as well as established practices for describing network models in publications. This hinders the critical evaluation of network models as well as their re-use. We analyze here 14 research papers proposing neuronal network models of different complexity and find widely varying approaches to model descriptions, with regard to both the means of description and the ordering and placement of material. We further observe great variation in the graphical representation of networks and the notation used in equations. Based on our observations, we propose a good model description practice, composed of guidelines for the organization of publications, a checklist for model descriptions, templates for tables presenting model structure, and guidelines for diagrams of networks. The main purpose of this good practice is to trigger a debate about the communication of neuronal network models in a manner comprehensible to humans, as opposed to machine-readable model description languages. We believe that the good model description practice proposed here, together with a number of other recent initiatives on data-, model-, and software-sharing, may lead to a deeper and more fruitful exchange of ideas among computational neuroscientists in years to come. We further hope that work on standardized ways of describing--and thinking about--complex neuronal networks will lead the scientific community to a clearer understanding of high-level concepts in network dynamics, and will thus lead to deeper insights into the function of the brain.

  17. Characterization and Modeling of Network Traffic

    DEFF Research Database (Denmark)

    Shawky, Ahmed; Bergheim, Hans; Ragnarsson, Olafur;

    2011-01-01

    This paper attempts to characterize and model backbone network traffic, using a small number of statistics. In order to reduce cost and processing power associated with traffic analysis. The parameters affecting the behaviour of network traffic are investigated and the choice is that inter......-arrival time, IP addresses, port numbers and transport protocol are the only necessary parameters to model network traffic behaviour. In order to recreate this behaviour, a complex model is needed which is able to recreate traffic behaviour based on a set of statistics calculated from the parameters values....... The model investigates the traffic generation mechanisms, and grouping traffic into flows and applications....

  18. Complex networks analysis in socioeconomic models

    CERN Document Server

    Varela, Luis M; Ausloos, Marcel; Carrete, Jesus

    2014-01-01

    This chapter aims at reviewing complex networks models and methods that were either developed for or applied to socioeconomic issues, and pertinent to the theme of New Economic Geography. After an introduction to the foundations of the field of complex networks, the present summary adds insights on the statistical mechanical approach, and on the most relevant computational aspects for the treatment of these systems. As the most frequently used model for interacting agent-based systems, a brief description of the statistical mechanics of the classical Ising model on regular lattices, together with recent extensions of the same model on small-world Watts-Strogatz and scale-free Albert-Barabasi complex networks is included. Other sections of the chapter are devoted to applications of complex networks to economics, finance, spreading of innovations, and regional trade and developments. The chapter also reviews results involving applications of complex networks to other relevant socioeconomic issues, including res...

  19. Boolean networks as modelling framework

    Directory of Open Access Journals (Sweden)

    Florian eGreil

    2012-08-01

    Full Text Available In a network, the components of a given system are represented as nodes, the interactions are abstracted as links between the nodes. Boolean networks refer to a class of dynamics on networks, in fact it is the simplest possible dynamics where each node has a value 0 or 1. This allows to investigate extensively the dynamics both analytically and by numerical experiments. The present article focuses on the theoretical concept of relevant components and the immediate application in plant biology, references for more in-depths treatment of the mathematical details are also given.

  20. Implementing network constraints in the EMPS model

    Energy Technology Data Exchange (ETDEWEB)

    Helseth, Arild; Warland, Geir; Mo, Birger; Fosso, Olav B.

    2010-02-15

    This report concerns the coupling of detailed market and network models for long-term hydro-thermal scheduling. Currently, the EPF model (Samlast) is the only tool available for this task for actors in the Nordic market. A new prototype for solving the coupled market and network problem has been developed. The prototype is based on the EMPS model (Samkjoeringsmodellen). Results from the market model are distributed to a detailed network model, where a DC load flow detects if there are overloads on monitored lines or intersections. In case of overloads, network constraints are generated and added to the market problem. Theoretical and implementation details for the new prototype are elaborated in this report. The performance of the prototype is tested against the EPF model on a 20-area Nordic dataset. (Author)

  1. Modelling and control of road traffic networks

    OpenAIRE

    Haut, Bertrand

    2007-01-01

    Road traffic networks offer a particularly challenging research subject to the control community. The traffic congestion around big cities is constantly increasing and is now becoming a major problem. However, the dynamics of a road network exhibit some complex behaviours such as nonlinearities, delays and saturation effects that prevent the use of some classical control algorithms. This thesis presents different models and control algorithms used for road traffic networks. The dynamics ar...

  2. Delivery Time Reliability Model of Logistics Network

    OpenAIRE

    Liusan Wu; Qingmei Tan; Yuehui Zhang

    2013-01-01

    Natural disasters like earthquake and flood will surely destroy the existing traffic network, usually accompanied by delivery delay or even network collapse. A logistics-network-related delivery time reliability model defined by a shortest-time entropy is proposed as a means to estimate the actual delivery time reliability. The less the entropy is, the stronger the delivery time reliability remains, and vice versa. The shortest delivery time is computed separately based on two different assum...

  3. Modelling of virtual production networks

    Directory of Open Access Journals (Sweden)

    2011-03-01

    Full Text Available Nowadays many companies, especially small and medium-sized enterprises (SMEs, specialize in a limited field of production. It requires forming virtual production networks of cooperating enterprises to manufacture better, faster and cheaper. Apart from that, some production orders cannot be realized, because there is not a company of sufficient production potential. In this case the virtual production networks of cooperating companies can realize these production orders. These networks have larger production capacity and many different resources. Therefore it can realize many more production orders together than each of them separately. Such organization allows for executing high quality product. The maintenance costs of production capacity and used resources are not so high. In this paper a methodology of rapid prototyping of virtual production networks is proposed. It allows to execute production orders on time considered existing logistic constraints.

  4. Introducing Synchronisation in Deterministic Network Models

    DEFF Research Database (Denmark)

    Schiøler, Henrik; Jessen, Jan Jakob; Nielsen, Jens Frederik D.;

    2006-01-01

    The paper addresses performance analysis for distributed real time systems through deterministic network modelling. Its main contribution is the introduction and analysis of models for synchronisation between tasks and/or network elements. Typical patterns of synchronisation are presented leading....... The suggested models are intended for incorporation into an existing analysis tool a.k.a. CyNC based on the MATLAB/SimuLink framework for graphical system analysis and design....

  5. Homophyly/Kinship Model: Naturally Evolving Networks

    Science.gov (United States)

    Li, Angsheng; Li, Jiankou; Pan, Yicheng; Yin, Xianchen; Yong, Xi

    2015-10-01

    It has been a challenge to understand the formation and roles of social groups or natural communities in the evolution of species, societies and real world networks. Here, we propose the hypothesis that homophyly/kinship is the intrinsic mechanism of natural communities, introduce the notion of the affinity exponent and propose the homophyly/kinship model of networks. We demonstrate that the networks of our model satisfy a number of topological, probabilistic and combinatorial properties and, in particular, that the robustness and stability of natural communities increase as the affinity exponent increases and that the reciprocity of the networks in our model decreases as the affinity exponent increases. We show that both homophyly/kinship and reciprocity are essential to the emergence of cooperation in evolutionary games and that the homophyly/kinship and reciprocity determined by the appropriate affinity exponent guarantee the emergence of cooperation in evolutionary games, verifying Darwin’s proposal that kinship and reciprocity are the means of individual fitness. We propose the new principle of structure entropy minimisation for detecting natural communities of networks and verify the functional module property and characteristic properties by a healthy tissue cell network, a citation network, some metabolic networks and a protein interaction network.

  6. Evaluating Network Models: A Likelihood Analysis

    CERN Document Server

    Wang, Wen-Qiang; Zhou, Tao

    2011-01-01

    Many models are put forward to mimic the evolution of real networked systems. A well-accepted way to judge the validity is to compare the modeling results with real networks subject to several structural features. Even for a specific real network, we cannot fairly evaluate the goodness of different models since there are too many structural features while there is no criterion to select and assign weights on them. Motivated by the studies on link prediction algorithms, we propose a unified method to evaluate the network models via the comparison of the likelihoods of the currently observed network driven by different models, with an assumption that the higher the likelihood is, the better the model is. We test our method on the real Internet at the Autonomous System (AS) level, and the results suggest that the Generalized Linear Preferential (GLP) model outperforms the Tel Aviv Network Generator (Tang), while both two models are better than the Barab\\'asi-Albert (BA) and Erd\\"os-R\\'enyi (ER) models. Our metho...

  7. Modelling and designing electric energy networks

    International Nuclear Information System (INIS)

    The author gives an overview of his research works in the field of electric network modelling. After a brief overview of technological evolutions from the telegraph to the all-electric fly-by-wire aircraft, he reports and describes various works dealing with a simplified modelling of electric systems and with fractal simulation. Then, he outlines the challenges for the design of electric networks, proposes a design process, gives an overview of various design models, methods and tools, and reports an application in the design of electric networks for future jumbo jets

  8. Stochastic discrete model of karstic networks

    Science.gov (United States)

    Jaquet, O.; Siegel, P.; Klubertanz, G.; Benabderrhamane, H.

    Karst aquifers are characterised by an extreme spatial heterogeneity that strongly influences their hydraulic behaviour and the transport of pollutants. These aquifers are particularly vulnerable to contamination because of their highly permeable networks of conduits. A stochastic model is proposed for the simulation of the geometry of karstic networks at a regional scale. The model integrates the relevant physical processes governing the formation of karstic networks. The discrete simulation of karstic networks is performed with a modified lattice-gas cellular automaton for a representative description of the karstic aquifer geometry. Consequently, more reliable modelling results can be obtained for the management and the protection of karst aquifers. The stochastic model was applied jointly with groundwater modelling techniques to a regional karst aquifer in France for the purpose of resolving surface pollution issues.

  9. Modeling GMPLS and Optical MPLS Networks

    DEFF Research Database (Denmark)

    Christiansen, Henrik Lehrmann; Wessing, Henrik

    2003-01-01

    . The MPLS concept is attractive because it can work as a unifying control structure. covering all technologies. This paper describes how a novel scheme for optical MPLS and circuit switched GMPLS based networks can incorporated in such multi-domain, MPLS-based scenarios and how it could be modeled. Network...

  10. Simple models of human brain functional networks.

    Science.gov (United States)

    Vértes, Petra E; Alexander-Bloch, Aaron F; Gogtay, Nitin; Giedd, Jay N; Rapoport, Judith L; Bullmore, Edward T

    2012-04-10

    Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selection pressures that drive their formation remain largely unknown. Here we consider generative models for the probability of a functional connection (an edge) between two cortical regions (nodes) separated by some Euclidean distance in anatomical space. In particular, we propose a model in which the embedded topology of brain networks emerges from two competing factors: a distance penalty based on the cost of maintaining long-range connections; and a topological term that favors links between regions sharing similar input. We show that, together, these two biologically plausible factors are sufficient to capture an impressive range of topological properties of functional brain networks. Model parameters estimated in one set of functional MRI (fMRI) data on normal volunteers provided a good fit to networks estimated in a second independent sample of fMRI data. Furthermore, slightly detuned model parameters also generated a reasonable simulation of the abnormal properties of brain functional networks in people with schizophrenia. We therefore anticipate that many aspects of brain network organization, in health and disease, may be parsimoniously explained by an economical clustering rule for the probability of functional connectivity between different brain areas.

  11. Network Design Models for Container Shipping

    DEFF Research Database (Denmark)

    Reinhardt, Line Blander; Kallehauge, Brian; Nielsen, Anders Nørrelund;

    This paper presents a study of the network design problem in container shipping. The paper combines the network design and fleet assignment problem into a mixed integer linear programming model minimizing the overall cost. The major contributions of this paper is that the time of a vessel route...

  12. Queueing models for mobile ad hoc networks

    NARCIS (Netherlands)

    Haan, de Roland

    2009-01-01

    This thesis presents models for the performance analysis of a recent communication paradigm: mobile ad hoc networking. The objective of mobile ad hoc networking is to provide wireless connectivity between stations in a highly dynamic environment. These dynamics are driven by the mobility of stations

  13. Cyber threat model for tactical radio networks

    Science.gov (United States)

    Kurdziel, Michael T.

    2014-05-01

    The shift to a full information-centric paradigm in the battlefield has allowed ConOps to be developed that are only possible using modern network communications systems. Securing these Tactical Networks without impacting their capabilities has been a challenge. Tactical networks with fixed infrastructure have similar vulnerabilities to their commercial counterparts (although they need to be secure against adversaries with greater capabilities, resources and motivation). However, networks with mobile infrastructure components and Mobile Ad hoc Networks (MANets) have additional unique vulnerabilities that must be considered. It is useful to examine Tactical Network based ConOps and use them to construct a threat model and baseline cyber security requirements for Tactical Networks with fixed infrastructure, mobile infrastructure and/or ad hoc modes of operation. This paper will present an introduction to threat model assessment. A definition and detailed discussion of a Tactical Network threat model is also presented. Finally, the model is used to derive baseline requirements that can be used to design or evaluate a cyber security solution that can be scaled and adapted to the needs of specific deployments.

  14. A Graphical User Interface for Parameterizing Biochemical Models of Photosynthesis and Chlorophyll Fluorescence

    Science.gov (United States)

    Kornfeld, A.; Van der Tol, C.; Berry, J. A.

    2015-12-01

    Recent advances in optical remote sensing of photosynthesis offer great promise for estimating gross primary productivity (GPP) at leaf, canopy and even global scale. These methods -including solar-induced chlorophyll fluorescence (SIF) emission, fluorescence spectra, and hyperspectral features such as the red edge and the photochemical reflectance index (PRI) - can be used to greatly enhance the predictive power of global circulation models (GCMs) by providing better constraints on GPP. The way to use measured optical data to parameterize existing models such as SCOPE (Soil Canopy Observation, Photochemistry and Energy fluxes) is not trivial, however. We have therefore extended a biochemical model to include fluorescence and other parameters in a coupled treatment. To help parameterize the model, we then use nonlinear curve-fitting routines to determine the parameter set that enables model results to best fit leaf-level gas exchange and optical data measurements. To make the tool more accessible to all practitioners, we have further designed a graphical user interface (GUI) based front-end to allow researchers to analyze data with a minimum of effort while, at the same time, allowing them to change parameters interactively to visualize how variation in model parameters affect predicted outcomes such as photosynthetic rates, electron transport, and chlorophyll fluorescence. Here we discuss the tool and its effectiveness, using recently-gathered leaf-level data.

  15. Model-based control of networked systems

    CERN Document Server

    Garcia, Eloy; Montestruque, Luis A

    2014-01-01

    This monograph introduces a class of networked control systems (NCS) called model-based networked control systems (MB-NCS) and presents various architectures and control strategies designed to improve the performance of NCS. The overall performance of NCS considers the appropriate use of network resources, particularly network bandwidth, in conjunction with the desired response of the system being controlled.   The book begins with a detailed description of the basic MB-NCS architecture that provides stability conditions in terms of state feedback updates . It also covers typical problems in NCS such as network delays, network scheduling, and data quantization, as well as more general control problems such as output feedback control, nonlinear systems stabilization, and tracking control.   Key features and topics include: Time-triggered and event-triggered feedback updates Stabilization of uncertain systems subject to time delays, quantization, and extended absence of feedback Optimal control analysis and ...

  16. Modeling trust context in networks

    CERN Document Server

    Adali, Sibel

    2013-01-01

    We make complex decisions every day, requiring trust in many different entities for different reasons. These decisions are not made by combining many isolated trust evaluations. Many interlocking factors play a role, each dynamically impacting the others.? In this brief, 'trust context' is defined as the system level description of how the trust evaluation process unfolds.Networks today are part of almost all human activity, supporting and shaping it. Applications increasingly incorporate new interdependencies and new trust contexts. Social networks connect people and organizations throughout

  17. New systematic methodology for incorporating dynamic heat transfer modelling in multi-phase biochemical reactors.

    Science.gov (United States)

    Fernández-Arévalo, T; Lizarralde, I; Grau, P; Ayesa, E

    2014-09-01

    This paper presents a new modelling methodology for dynamically predicting the heat produced or consumed in the transformations of any biological reactor using Hess's law. Starting from a complete description of model components stoichiometry and formation enthalpies, the proposed modelling methodology has integrated successfully the simultaneous calculation of both the conventional mass balances and the enthalpy change of reaction in an expandable multi-phase matrix structure, which facilitates a detailed prediction of the main heat fluxes in the biochemical reactors. The methodology has been implemented in a plant-wide modelling methodology in order to facilitate the dynamic description of mass and heat throughout the plant. After validation with literature data, as illustrative examples of the capability of the methodology, two case studies have been described. In the first one, a predenitrification-nitrification dynamic process has been analysed, with the aim of demonstrating the easy integration of the methodology in any system. In the second case study, the simulation of a thermal model for an ATAD has shown the potential of the proposed methodology for analysing the effect of ventilation and influent characterization.

  18. Watershed modeling of dissolved oxygen and biochemical oxygen demand using a hydrological simulation Fortran program.

    Science.gov (United States)

    Liu, Zhijun; Kieffer, Janna M; Kingery, William L; Huddleston, David H; Hossain, Faisal

    2007-11-01

    Several inland water bodies in the St. Louis Bay watershed have been identified as being potentially impaired due to low level of dissolved oxygen (DO). In order to calculate the total maximum daily loads (TMDL), a standard watershed model supported by U.S. Environmental Protection Agency, Hydrological Simulation Program Fortran (HSPF), was used to simulate water temperature, DO, and bio-chemical oxygen demand (BOD). Both point and non-point sources of BOD were included in watershed modeling. The developed model was calibrated at two time periods: 1978 to 1986 and 2000 to 2001 with simulated DO closely matched the observed data and captured the seasonal variations. The model represented the general trend and average condition of observed BOD. Water temperature and BOD decay are the major factors that affect DO simulation, whereas nutrient processes, including nitrification, denitrification, and phytoplankton cycle, have slight impacts. The calibrated water quality model provides a representative linkage between the sources of BOD and in-stream DO\\BOD concentrations. The developed input parameters in this research could be extended to similar coastal watersheds for TMDL determination and Best Management Practice (BMP) evaluation.

  19. Modeling Network Traffic in Wavelet Domain

    Directory of Open Access Journals (Sweden)

    Sheng Ma

    2004-12-01

    Full Text Available This work discovers that although network traffic has the complicated short- and long-range temporal dependence, the corresponding wavelet coefficients are no longer long-range dependent. Therefore, a "short-range" dependent process can be used to model network traffic in the wavelet domain. Both independent and Markov models are investigated. Theoretical analysis shows that the independent wavelet model is sufficiently accurate in terms of the buffer overflow probability for Fractional Gaussian Noise traffic. Any model, which captures additional correlations in the wavelet domain, only improves the performance marginally. The independent wavelet model is then used as a unified approach to model network traffic including VBR MPEG video and Ethernet data. The computational complexity is O(N for developing such wavelet models and generating synthesized traffic of length N, which is among the lowest attained.

  20. Graphical Model Theory for Wireless Sensor Networks

    Energy Technology Data Exchange (ETDEWEB)

    Davis, William B.

    2002-12-08

    Information processing in sensor networks, with many small processors, demands a theory of computation that allows the minimization of processing effort, and the distribution of this effort throughout the network. Graphical model theory provides a probabilistic theory of computation that explicitly addresses complexity and decentralization for optimizing network computation. The junction tree algorithm, for decentralized inference on graphical probability models, can be instantiated in a variety of applications useful for wireless sensor networks, including: sensor validation and fusion; data compression and channel coding; expert systems, with decentralized data structures, and efficient local queries; pattern classification, and machine learning. Graphical models for these applications are sketched, and a model of dynamic sensor validation and fusion is presented in more depth, to illustrate the junction tree algorithm.

  1. Monochromaticity in neutral evolutionary network models.

    Science.gov (United States)

    Halu, Arda; Bianconi, Ginestra

    2012-12-01

    Recent studies on epistatic networks of model organisms have unveiled a certain type of modular property called monochromaticity in which the networks are clustered into functional modules that interact with each other through the same type of epistasis. Here, we propose and study three epistatic network models that are inspired by the duplication-divergence mechanism to gain insight into the evolutionary basis of monochromaticity and to test if it can be explained as the outcome of a neutral evolutionary hypothesis. We show that the epistatic networks formed by these stochastic evolutionary models have monochromaticity conflict distributions that are centered close to zero and are statistically significantly different from their randomized counterparts. In particular, the last model we propose yields a strictly monochromatic solution. Our results agree with the monochromaticity findings in real organisms and point toward the possible role of a neutral mechanism in the evolution of this phenomenon. PMID:23367998

  2. Graphical Model Theory for Wireless Sensor Networks

    International Nuclear Information System (INIS)

    Information processing in sensor networks, with many small processors, demands a theory of computation that allows the minimization of processing effort, and the distribution of this effort throughout the network. Graphical model theory provides a probabilistic theory of computation that explicitly addresses complexity and decentralization for optimizing network computation. The junction tree algorithm, for decentralized inference on graphical probability models, can be instantiated in a variety of applications useful for wireless sensor networks, including: sensor validation and fusion; data compression and channel coding; expert systems, with decentralized data structures, and efficient local queries; pattern classification, and machine learning. Graphical models for these applications are sketched, and a model of dynamic sensor validation and fusion is presented in more depth, to illustrate the junction tree algorithm

  3. Modelling subtle growth of linguistic networks

    CERN Document Server

    Kulig, Andrzej; Kwapien, Jaroslaw; Oswiecimka, Pawel

    2014-01-01

    We investigate properties of evolving linguistic networks defined by the word-adjacency relation. Such networks belong to the category of networks with accelerated growth but their shortest path length appears to reveal the network size dependence of different functional form than the ones known so far. We thus compare the networks created from literary texts with their artificial substitutes based on different variants of the Dorogovtsev-Mendes model and observe that none of them is able to properly simulate the novel asymptotics of the shortest path length. Then, we identify grammar induced local chain-like linear growth as a missing element in this model and extend it by incorporating such effects. It is in this way that a satisfactory agreement with the empirical result is obtained.

  4. Development of Computer Aided Modelling Templates for Model Re-use in Chemical and Biochemical Process and Product Design: Importand export of models

    DEFF Research Database (Denmark)

    Fedorova, Marina; Tolksdorf, Gregor; Fillinger, Sandra;

    2015-01-01

    been established, in order to provide a wider range of modelling capabilities. Through this link, developed models can be exported/imported to/from other modelling-simulation software environments to allow model reusability in chemical and biochemical product and process design. The use of this link......This paper focuses on the challenges in model development related to model reuse and compatibility and integration of different tools that are used in modelling. A link between two modelling tools, the computer-aided modelling framework of the ICAS system and the modelling environment, MOSAIC, has...

  5. Survey of propagation Model in wireless Network

    OpenAIRE

    Hemant Kumar Sharma; Sanjeev Sharma; Krishna Kumar Pandey

    2011-01-01

    To implementation of mobile ad hoc network wave propagation models are necessary to determine propagation characteristic through a medium. Wireless mobile ad hoc networks are self creating and self organizing entity. Propagation study provides an estimation of signal characteristics. Accurate prediction of radio propagation behaviour for MANET is becoming a difficult task. This paper presents investigation of propagation model. Radio wave propagation mechanisms are absorption, reflection, ref...

  6. IP Network Management Model Based on NGOSS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jin-yu; LI Hong-hui; LIU Feng

    2004-01-01

    This paper addresses a management model for IP network based on Next Generation Operation Support System (NGOSS). It makes the network management on the base of all the operation actions of ISP, It provides QoS to user service through the whole path by providing end-to-end Service Level Agreements (SLA) management through whole path. Based on web and coordination technology, this paper gives an implement architecture of this model.

  7. Energy-oriented models for WDM networks

    OpenAIRE

    Ricciardi, Sergio; Careglio, Davide; Palmieri, Francesco; Fiore, Ugo; Santos Boada, Germán; Solé Pareta, Josep

    2010-01-01

    A realistic energy-oriented model is necessary to formally characterize the energy consumption and the consequent carbon footprint of actual and future high-capacity WDM networks. The energy model describes the energy consumption of the various network elements (NE) and predicts their energy consumption behavior under different traffic loads and for the diverse traffic types, including all optical and electronic traffic, O/E/O conversions, 3R regenerations, add/drop multiplexing, etc. Besi...

  8. Model-Based Clustering of Large Networks

    CERN Document Server

    Vu, Duy Quang; Schweinberger, Michael

    2012-01-01

    We describe a network clustering framework, based on finite mixture models, that can be applied to discrete-valued networks with hundreds of thousands of nodes and billions of edge variables. Relative to other recent model-based clustering work for networks, we introduce a more flexible modeling framework, improve the variational-approximation estimation algorithm, discuss and implement standard error estimation via a parametric bootstrap approach, and apply these methods to much larger datasets than those seen elsewhere in the literature. The more flexible modeling framework is achieved through introducing novel parameterizations of the model, giving varying degrees of parsimony, using exponential family models whose structure may be exploited in various theoretical and algorithmic ways. The algorithms, which we show how to adapt to the more complicated optimization requirements introduced by the constraints imposed by the novel parameterizations we propose, are based on variational generalized EM algorithms...

  9. A survey of statistical network models

    CERN Document Server

    Goldenberg, Anna; Fienberg, Stephen E; Airoldi, Edoardo M

    2009-01-01

    Networks are ubiquitous in science and have become a focal point for discussion in everyday life. Formal statistical models for the analysis of network data have emerged as a major topic of interest in diverse areas of study, and most of these involve a form of graphical representation. Probability models on graphs date back to 1959. Along with empirical studies in social psychology and sociology from the 1960s, these early works generated an active network community and a substantial literature in the 1970s. This effort moved into the statistical literature in the late 1970s and 1980s, and the past decade has seen a burgeoning network literature in statistical physics and computer science. The growth of the World Wide Web and the emergence of online networking communities such as Facebook, MySpace, and LinkedIn, and a host of more specialized professional network communities has intensified interest in the study of networks and network data. Our goal in this review is to provide the reader with an entry poin...

  10. Designing Network-based Business Model Ontology

    DEFF Research Database (Denmark)

    Hashemi Nekoo, Ali Reza; Ashourizadeh, Shayegheh; Zarei, Behrouz

    2015-01-01

    Survival on dynamic environment is not achieved without a map. Scanning and monitoring of the market show business models as a fruitful tool. But scholars believe that old-fashioned business models are dead; as they are not included the effect of internet and network in themselves. This paper...... such as shared-mental model and trust. However, it mostly covers previous business model elements. To confirm the applicability of this ontology, it has been implemented in business angel network and showed how it works....

  11. Network Modeling and Simulation A Practical Perspective

    CERN Document Server

    Guizani, Mohsen; Khan, Bilal

    2010-01-01

    Network Modeling and Simulation is a practical guide to using modeling and simulation to solve real-life problems. The authors give a comprehensive exposition of the core concepts in modeling and simulation, and then systematically address the many practical considerations faced by developers in modeling complex large-scale systems. The authors provide examples from computer and telecommunication networks and use these to illustrate the process of mapping generic simulation concepts to domain-specific problems in different industries and disciplines. Key features: Provides the tools and strate

  12. Modeling, Optimization & Control of Hydraulic Networks

    DEFF Research Database (Denmark)

    Tahavori, Maryamsadat

    2014-01-01

    . The nonlinear network model is derived based on the circuit theory. A suitable projection is used to reduce the state vector and to express the model in standard state-space form. Then, the controllability of nonlinear nonaffine hydraulic networks is studied. The Lie algebra-based controllability matrix is used...... to solve nonlinear optimal control problems. In the water supply system model, the hydraulic resistance of the valve is estimated by real data and it is considered to be a disturbance. The disturbance in our system is updated every 24 hours based on the amount of water usage by consumers every day. Model...

  13. Performance modeling, stochastic networks, and statistical multiplexing

    CERN Document Server

    Mazumdar, Ravi R

    2013-01-01

    This monograph presents a concise mathematical approach for modeling and analyzing the performance of communication networks with the aim of introducing an appropriate mathematical framework for modeling and analysis as well as understanding the phenomenon of statistical multiplexing. The models, techniques, and results presented form the core of traffic engineering methods used to design, control and allocate resources in communication networks.The novelty of the monograph is the fresh approach and insights provided by a sample-path methodology for queueing models that highlights the importan

  14. MODEL FOR NETWORKED BUSINESS: Case study of Application Service Provider's network

    OpenAIRE

    Pesonen, Tero

    2011-01-01

    MODEL FOR NETWORKED BUSINESS Case study of Application Service Provider's network The aim of the research was to create a network business model to optimise benefits for a business network in the area of software industry. The main research questions were: ? What kind of network business models can be found? ? What are the value creation mechanisms as well as advantages and disadvantages of different models? ? How to use former frameworks to develop a network business mode...

  15. Modeling Emergence in Neuroprotective Regulatory Networks

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Haack, Jereme N.; McDermott, Jason E.; Stevens, S.L.; Stenzel-Poore, Mary

    2013-01-05

    The use of predictive modeling in the analysis of gene expression data can greatly accelerate the pace of scientific discovery in biomedical research by enabling in silico experimentation to test disease triggers and potential drug therapies. Techniques that focus on modeling emergence, such as agent-based modeling and multi-agent simulations, are of particular interest as they support the discovery of pathways that may have never been observed in the past. Thus far, these techniques have been primarily applied at the multi-cellular level, or have focused on signaling and metabolic networks. We present an approach where emergence modeling is extended to regulatory networks and demonstrate its application to the discovery of neuroprotective pathways. An initial evaluation of the approach indicates that emergence modeling provides novel insights for the analysis of regulatory networks that can advance the discovery of acute treatments for stroke and other diseases.

  16. Optimal transportation networks models and theory

    CERN Document Server

    Bernot, Marc; Morel, Jean-Michel

    2009-01-01

    The transportation problem can be formalized as the problem of finding the optimal way to transport a given measure into another with the same mass. In contrast to the Monge-Kantorovitch problem, recent approaches model the branched structure of such supply networks as minima of an energy functional whose essential feature is to favour wide roads. Such a branched structure is observable in ground transportation networks, in draining and irrigation systems, in electrical power supply systems and in natural counterparts such as blood vessels or the branches of trees. These lectures provide mathematical proof of several existence, structure and regularity properties empirically observed in transportation networks. The link with previous discrete physical models of irrigation and erosion models in geomorphology and with discrete telecommunication and transportation models is discussed. It will be mathematically proven that the majority fit in the simple model sketched in this volume.

  17. Reconstruction and Use of Microbial Metabolic Networks: the Core Escherichia coli Metabolic Model as an Educational Guide.

    Science.gov (United States)

    Orth, Jeffrey D; Fleming, R M T; Palsson, Bernhard Ø

    2010-09-01

    Biochemical network reconstructions have become popular tools in systems biology. Metabolicnetwork reconstructions are biochemically, genetically, and genomically (BiGG) structured databases of biochemical reactions and metabolites. They contain information such as exact reaction stoichiometry, reaction reversibility, and the relationships between genes, proteins, and reactions. Network reconstructions have been used extensively to study the phenotypic behavior of wild-type and mutant stains under a variety of conditions, linking genotypes with phenotypes. Such phenotypic simulations have allowed for the prediction of growth after genetic manipulations, prediction of growth phenotypes after adaptive evolution, and prediction of essential genes. Additionally, because network reconstructions are organism specific, they can be used to understand differences between organisms of species in a functional context.There are different types of reconstructions representing various types of biological networks (metabolic, regulatory, transcription/translation). This chapter serves as an introduction to metabolic and regulatory network reconstructions and models and gives a complete description of the core Escherichia coli metabolic model. This model can be analyzed in any computational format (such as MATLAB or Mathematica) based on the information given in this chapter. The core E. coli model is a small-scale model that can be used for educational purposes. It is meant to be used by senior undergraduate and first-year graduate students learning about constraint-based modeling and systems biology. This model has enough reactions and pathways to enable interesting and insightful calculations, but it is also simple enough that the results of such calculations can be understoodeasily.

  18. Modeling of urban traffic networks with lattice Boltzmann model

    Science.gov (United States)

    Meng, Jian-ping; Qian, Yue-hong; Dai, Shi-qiang

    2008-02-01

    It is of great importance to uncover the characteristics of traffic networks. However, there have been few researches concerning kinetics models for urban traffic networks. In this work, a lattice Boltzmann model (LBM) for urban traffic networks is proposed by incorporating the ideas of the Biham-Middleton-Levine (BML) model into the LBM for road traffic. In the present model, situations at intersections with the red and green traffic signals are treated as a kind of boundary conditions varying with time. Thus, the urban traffic network could be described in the mesoscopic level. By performing numerical simulations under the periodic boundary conditions, the behavior of average velocity is investigated in detail. The numerical results agree quite well with those given by the Chowdhury-Schadschneider (ChSch) model (Chowdhury D. and Schadschneider A., Phys. Rev. E, 59 (1999) R1311). Furthermore, the statistical noise is reduced in this discrete kinetics model, thus, the present model has considerably high computational efficiency.

  19. Enhanced Gravity Model of trade: reconciling macroeconomic and network models

    CERN Document Server

    Almog, Assaf; Garlaschelli, Diego

    2015-01-01

    The bilateral trade relations between world countries form a complex network, the International Trade Network (ITN), which is involved in an increasing number of worldwide economic processes, including globalization, integration, industrial production, and the propagation of shocks and instabilities. Characterizing the ITN via a simple yet accurate model is an open problem. The classical Gravity Model of trade successfully reproduces the volume of trade between two connected countries using known macroeconomic properties such as GDP and geographic distance. However, it generates a network with an unrealistically homogeneous topology, thus failing to reproduce the highly heterogeneous structure of the real ITN. On the other hand, network models successfully reproduce the complex topology of the ITN, but provide no information about trade volumes. Therefore macroeconomic and network models of trade suffer from complementary limitations but are still largely incompatible. Here, we make an important step forward ...

  20. An evolving network model with modular growth

    Institute of Scientific and Technical Information of China (English)

    Zou Zhi-Yun; Liu Peng; Lei Li; Gao Jian-Zhi

    2012-01-01

    In this paper,we propose an evolving network model growing fast in units of module,according to the analysis of the evolution characteristics in real complex networks.Each module is a small-world network containing several interconnected nodes and the nodes between the modules are linked by preferential attachment on degree of nodes.We study the modularity measure of the proposed model,which can be adjusted by changing the ratio of the number of innermodule edges and the number of inter-module edges.In view of the mean-field theory,we develop an analytical function of the degree distribution,which is verified by a numerical example and indicates that the degree distribution shows characteristics of the small-world network and the scale-free network distinctly at different segments.The clustering coefficient and the average path length of the network are simulated numerically,indicating that the network shows the small-world property and is affected little by the randomness of the new module.

  1. Modelling complex networks by random hierarchical graphs

    Directory of Open Access Journals (Sweden)

    M.Wróbel

    2008-06-01

    Full Text Available Numerous complex networks contain special patterns, called network motifs. These are specific subgraphs, which occur oftener than in randomized networks of Erdős-Rényi type. We choose one of them, the triangle, and build a family of random hierarchical graphs, being Sierpiński gasket-based graphs with random "decorations". We calculate the important characteristics of these graphs - average degree, average shortest path length, small-world graph family characteristics. They depend on probability of decorations. We analyze the Ising model on our graphs and describe its critical properties using a renormalization-group technique.

  2. A Network Model of Credit Risk Contagion

    Directory of Open Access Journals (Sweden)

    Ting-Qiang Chen

    2012-01-01

    Full Text Available A network model of credit risk contagion is presented, in which the effect of behaviors of credit risk holders and the financial market regulators and the network structure are considered. By introducing the stochastic dominance theory, we discussed, respectively, the effect mechanisms of the degree of individual relationship, individual attitude to credit risk contagion, the individual ability to resist credit risk contagion, the monitoring strength of the financial market regulators, and the network structure on credit risk contagion. Then some derived and proofed propositions were verified through numerical simulations.

  3. Grid architecture model of network centric warfare

    Institute of Scientific and Technical Information of China (English)

    Yan Tihua; Wang Baoshu

    2006-01-01

    NCW(network centric warfare) is an information warfare concentrating on network. A global network-centric warfare architecture with OGSA grid technology is put forward, which is a four levels system including the user level, the application level, the grid middleware layer and the resource level. In grid middleware layer, based on virtual hosting environment, a BEPL4WS grid service composition method is introduced. In addition, the NCW grid service model is built with the help of Eclipse-SDK-3.0.1 and Bpws4j.

  4. Spatial Models and Networks of Living Systems

    DEFF Research Database (Denmark)

    Juul, Jeppe Søgaard

    variables of the system. However, this approach disregards any spatial structure of the system, which may potentially change the behaviour drastically. An alternative approach is to construct a cellular automaton with nearest neighbour interactions, or even to model the system as a complex network....... Such systems are known to be stabilized by spatial structure. Finally, I analyse data from a large mobile phone network and show that people who are topologically close in the network have similar communication patterns. This main part of the thesis is based on six different articles, which I have co...

  5. Toward an Animal Model of the Human Tear Film: Biochemical Comparison of the Mouse, Canine, Rabbit, and Human Meibomian Lipidomes

    OpenAIRE

    Butovich, Igor A.; Lu, Hua; McMahon, Anne; Eule, J Corinna

    2012-01-01

    A side by side comparison of the rabbit and the human meibum demonstrated their vast biochemical differences. Thus, the rabbit seems to be a poor animal model of the human tear film studies. Mice and canines, on the other hand, were found to be very similar to humans and should be considered instead.

  6. Knowledge Transposition from Tropical Fish Serum Proteins to Fundamental Education Students Through Biochemical Models

    Directory of Open Access Journals (Sweden)

    E.V.M. Maciel de Carvalho

    2010-05-01

    Full Text Available The subject was represented and discussed at The National Week of Science and Technology, UFPE, an initiative from The Ministry of Science and Technology to encourage children and people in science and technology activities. The work aimed to renew the importance to transmit knowledge from simple, imaginative, biochemical models and interactive teaching. The stand tool contained an aquarium with fishes, five scale models showing peptide bond, carbohydrate inhibited lectin molecule, hemagglutination reaction, lectin-bacterium surface interaction and enzyme-substract-inhibitor. Posters described tropical fish importance and methods applied to obtain fish serum and organs to purify lectins and protein inhibitors as well as to extract tissue DNA; notions were transmitted on fish immunology and diseases. The students were attracted and impressed with the exotic fishes most cultivated in Brazil; they asked if it is necessary to kill the fish to extract lectin and about lectin importance. Students were also interested to know if all fish enzyme/inhibitors are favorable to the own fish organism. The work succeeded to inform and stimulate future scientists in the field and to awake their scientific curiosity.

  7. Modeling Computations in a Semantic Network

    CERN Document Server

    Rodriguez, Marko A

    2007-01-01

    Semantic network research has seen a resurgence from its early history in the cognitive sciences with the inception of the Semantic Web initiative. The Semantic Web effort has brought forth an array of technologies that support the encoding, storage, and querying of the semantic network data structure at the world stage. Currently, the popular conception of the Semantic Web is that of a data modeling medium where real and conceptual entities are related in semantically meaningful ways. However, new models have emerged that explicitly encode procedural information within the semantic network substrate. With these new technologies, the Semantic Web has evolved from a data modeling medium to a computational medium. This article provides a classification of existing computational modeling efforts and the requirements of supporting technologies that will aid in the further growth of this burgeoning domain.

  8. Dynamic Modeling of the Electric Transportation Network

    CERN Document Server

    Scir`e, A; Eguiluz, V M; Scir\\`{e}, Alessandro; Tuval, Id\\'an

    2005-01-01

    We introduce a model for the dynamic self-organization of the electric grid. The model is characterized by a conserved magnitude, energy, that can travel following the links of the network to satisfy nodes' load. The load fluctuates in time causing local overloads that drive the dynamic evolution of the network topology. Our model displays a transition from a fully connected network to a configuration with a non-trivial topology and where global failures are suppressed. The most efficient topology is characterized by an exponential degree distribution, in agreement with the topology of the real electric grid. The model intrinsically presents self-induced break-down events, which can be thought as representative of real black-outs.

  9. Keystone Business Models for Network Security Processors

    OpenAIRE

    Arthur Low; Steven Muegge

    2013-01-01

    Network security processors are critical components of high-performance systems built for cybersecurity. Development of a network security processor requires multi-domain experience in semiconductors and complex software security applications, and multiple iterations of both software and hardware implementations. Limited by the business models in use today, such an arduous task can be undertaken only by large incumbent companies and government organizations. Neither the “fabless semiconductor...

  10. Decomposed Implicit Models of Piecewise - Linear Networks

    Directory of Open Access Journals (Sweden)

    J. Brzobohaty

    1992-05-01

    Full Text Available The general matrix form of the implicit description of a piecewise-linear (PWL network and the symbolic block diagram of the corresponding circuit model are proposed. Their decomposed forms enable us to determine quite separately the existence of the individual breakpoints of the resultant PWL characteristic and their coordinates using independent network parameters. For the two-diode and three-diode cases all the attainable types of the PWL characteristic are introduced.

  11. Stochastic modeling and analysis of telecoms networks

    CERN Document Server

    Decreusefond, Laurent

    2012-01-01

    This book addresses the stochastic modeling of telecommunication networks, introducing the main mathematical tools for that purpose, such as Markov processes, real and spatial point processes and stochastic recursions, and presenting a wide list of results on stability, performances and comparison of systems.The authors propose a comprehensive mathematical construction of the foundations of stochastic network theory: Markov chains, continuous time Markov chains are extensively studied using an original martingale-based approach. A complete presentation of stochastic recursions from an

  12. Non-nequilibrium model on Apollonian networks

    CERN Document Server

    Lima, F W S; Araújo, Ascânio D

    2012-01-01

    We investigate the Majority-Vote Model with two states ($-1,+1$) and a noise $q$ on Apollonian networks. The main result found here is the presence of the phase transition as a function of the noise parameter $q$. We also studies de effect of redirecting a fraction $p$ of the links of the network. By means of Monte Carlo simulations, we obtained the exponent ratio $\\gamma/\

  13. Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia.

    Directory of Open Access Journals (Sweden)

    Ignat Drozdov

    Full Text Available Small intestinal (SI neuroendocrine tumors (NET are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments can objectively define signaling machinery in this disease. Genome-wide co-expression analysis was used to infer gene relevance network in SI-NETs. The network was confirmed to be non-random, scale-free, and highly modular. Functional analysis of gene co-expression modules revealed processes including 'Nervous system development', 'Immune response', and 'Cell-cycle'. Importantly, gene network topology and differential expression analysis identified over-expression of the GPCR signaling regulators, the cAMP synthetase, ADCY2, and the protein kinase A, PRKAR1A. Seven CREB response element (CRE transcripts associated with proliferation and secretion: BEX1, BICD1, CHGB, CPE, GABRB3, SCG2 and SCG3 as well as ADCY2 and PRKAR1A were measured in an independent SI dataset (n = 10 NETs; n = 8 normal preparations. All were up-regulated (p<0.035 with the exception of SCG3 which was not differently expressed. Forskolin (a direct cAMP activator, 10(-5 M significantly stimulated transcription of pCREB and 3/7 CREB targets, isoproterenol (a selective ß-adrenergic receptor agonist and cAMP activator, 10(-5 M stimulated pCREB and 4/7 targets while BIM-53061 (a dopamine D(2 and Serotonin [5-HT(2] receptor agonist, 10(-6 M stimulated 100% of targets as well as pCREB; CRE transcription correlated with the levels of cAMP accumulation and PKA activity; BIM-53061 stimulated the highest levels of cAMP and PKA (2.8-fold and 2.5-fold vs. 1.8-2-fold for isoproterenol and forskolin. Gene network inference and graph topology analysis in SI NETs suggests that SI NETs express neural GPCRs that activate different CRE targets associated with proliferation and secretion. In vitro studies, in a model NET cell system, confirmed that transcriptional

  14. Evaluation of EOR Processes Using Network Models

    DEFF Research Database (Denmark)

    Larsen, Jens Kjell; Krogsbøll, Anette

    1998-01-01

    The report consists of the following parts: 1) Studies of wetting properties of model fluids and fluid mixtures aimed at an optimal selection of candidates for micromodel experiments. 2) Experimental studies of multiphase transport properties using physical models of porous networks (micromodels)...

  15. Modelling cooperative agents in infrastructure networks

    NARCIS (Netherlands)

    Ligtvoet, A.; Chappin, E.J.L.; Stikkelman, R.M.

    2010-01-01

    This paper describes the translation of concepts of cooperation into an agent-based model of an industrial network. It first addresses the concept of cooperation and how this could be captured as heuristical rules within agents. Then it describes tests using these heuristics in an abstract model of

  16. Empirical generalization assessment of neural network models

    DEFF Research Database (Denmark)

    Larsen, Jan; Hansen, Lars Kai

    1995-01-01

    This paper addresses the assessment of generalization performance of neural network models by use of empirical techniques. We suggest to use the cross-validation scheme combined with a resampling technique to obtain an estimate of the generalization performance distribution of a specific model...

  17. Nonconsensus opinion model on directed networks.

    Science.gov (United States)

    Qu, Bo; Li, Qian; Havlin, Shlomo; Stanley, H Eugene; Wang, Huijuan

    2014-11-01

    Dynamic social opinion models have been widely studied on undirected networks, and most of them are based on spin interaction models that produce a consensus. In reality, however, many networks such as Twitter and the World Wide Web are directed and are composed of both unidirectional and bidirectional links. Moreover, from choosing a coffee brand to deciding who to vote for in an election, two or more competing opinions often coexist. In response to this ubiquity of directed networks and the coexistence of two or more opinions in decision-making situations, we study a nonconsensus opinion model introduced by Shao et al. [Phys. Rev. Lett. 103, 018701 (2009)PRLTAO0031-900710.1103/PhysRevLett.103.018701] on directed networks. We define directionality ξ as the percentage of unidirectional links in a network, and we use the linear correlation coefficient ρ between the in-degree and out-degree of a node to quantify the relation between the in-degree and out-degree. We introduce two degree-preserving rewiring approaches which allow us to construct directed networks that can have a broad range of possible combinations of directionality ξ and linear correlation coefficient ρ and to study how ξ and ρ impact opinion competitions. We find that, as the directionality ξ or the in-degree and out-degree correlation ρ increases, the majority opinion becomes more dominant and the minority opinion's ability to survive is lowered. PMID:25493838

  18. Nonconsensus opinion model on directed networks

    Science.gov (United States)

    Qu, Bo; Li, Qian; Havlin, Shlomo; Stanley, H. Eugene; Wang, Huijuan

    2014-11-01

    Dynamic social opinion models have been widely studied on undirected networks, and most of them are based on spin interaction models that produce a consensus. In reality, however, many networks such as Twitter and the World Wide Web are directed and are composed of both unidirectional and bidirectional links. Moreover, from choosing a coffee brand to deciding who to vote for in an election, two or more competing opinions often coexist. In response to this ubiquity of directed networks and the coexistence of two or more opinions in decision-making situations, we study a nonconsensus opinion model introduced by Shao et al. [Phys. Rev. Lett. 103, 018701 (2009), 10.1103/PhysRevLett.103.018701] on directed networks. We define directionality ξ as the percentage of unidirectional links in a network, and we use the linear correlation coefficient ρ between the in-degree and out-degree of a node to quantify the relation between the in-degree and out-degree. We introduce two degree-preserving rewiring approaches which allow us to construct directed networks that can have a broad range of possible combinations of directionality ξ and linear correlation coefficient ρ and to study how ξ and ρ impact opinion competitions. We find that, as the directionality ξ or the in-degree and out-degree correlation ρ increases, the majority opinion becomes more dominant and the minority opinion's ability to survive is lowered.

  19. Dual modeling of political opinion networks

    Science.gov (United States)

    Wang, R.; A. Wang, Q.

    2011-09-01

    We present the result of a dual modeling of opinion networks. The model complements the agent-based opinion models by attaching to the social agent (voters) network a political opinion (party) network having its own intrinsic mechanisms of evolution. These two subnetworks form a global network, which can be either isolated from, or dependent on, the external influence. Basically, the evolution of the agent network includes link adding and deleting, with the opinion changes influenced by social validation, the political climate, the attractivity of the parties, and the interaction between them. The opinion network is initially composed of numerous nodes representing opinions or parties that are located on a one dimensional axis according to their political positions. The mechanism of evolution includes union, splitting, change of position, and attractivity, taking into account the pairwise node interaction decaying with node distance in power law. The global evolution ends in a stable distribution of the social agents over a quasistable and fluctuating stationary number of remaining parties. Empirical study on the lifetime distribution of numerous parties and vote results is carried out to verify numerical results.

  20. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.

    Science.gov (United States)

    Saez-Rodriguez, Julio; Alexopoulos, Leonidas G; Zhang, Mingsheng; Morris, Melody K; Lauffenburger, Douglas A; Sorger, Peter K

    2011-08-15

    Substantial effort in recent years has been devoted to constructing and analyzing large-scale gene and protein networks on the basis of "omic" data and literature mining. These interaction graphs provide valuable insight into the topologies of complex biological networks but are rarely context specific and cannot be used to predict the responses of cell signaling proteins to specific ligands or drugs. Conversely, traditional approaches to analyzing cell signaling are narrow in scope and cannot easily make use of network-level data. Here, we combine network analysis and functional experimentation by using a hybrid approach in which graphs are converted into simple mathematical models that can be trained against biochemical data. Specifically, we created Boolean logic models of immediate-early signaling in liver cells by training a literature-based prior knowledge network against biochemical data obtained from primary human hepatocytes and 4 hepatocellular carcinoma cell lines exposed to combinations of cytokines and small-molecule kinase inhibitors. Distinct families of models were recovered for each cell type, and these families clustered topologically into normal and diseased sets.

  1. Delay and Disruption Tolerant Networking MACHETE Model

    Science.gov (United States)

    Segui, John S.; Jennings, Esther H.; Gao, Jay L.

    2011-01-01

    To verify satisfaction of communication requirements imposed by unique missions, as early as 2000, the Communications Networking Group at the Jet Propulsion Laboratory (JPL) saw the need for an environment to support interplanetary communication protocol design, validation, and characterization. JPL's Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE), described in Simulator of Space Communication Networks (NPO-41373) NASA Tech Briefs, Vol. 29, No. 8 (August 2005), p. 44, combines various commercial, non-commercial, and in-house custom tools for simulation and performance analysis of space networks. The MACHETE environment supports orbital analysis, link budget analysis, communications network simulations, and hardware-in-the-loop testing. As NASA is expanding its Space Communications and Navigation (SCaN) capabilities to support planned and future missions, building infrastructure to maintain services and developing enabling technologies, an important and broader role is seen for MACHETE in design-phase evaluation of future SCaN architectures. To support evaluation of the developing Delay Tolerant Networking (DTN) field and its applicability for space networks, JPL developed MACHETE models for DTN Bundle Protocol (BP) and Licklider/Long-haul Transmission Protocol (LTP). DTN is an Internet Research Task Force (IRTF) architecture providing communication in and/or through highly stressed networking environments such as space exploration and battlefield networks. Stressed networking environments include those with intermittent (predictable and unknown) connectivity, large and/or variable delays, and high bit error rates. To provide its services over existing domain specific protocols, the DTN protocols reside at the application layer of the TCP/IP stack, forming a store-and-forward overlay network. The key capabilities of the Bundle Protocol include custody-based reliability, the ability to cope with intermittent connectivity

  2. Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease

    Institute of Scientific and Technical Information of China (English)

    Eduardo Vilar Gomez; Luis Calzadilla Bertot; Bienvenido Gra Oramas; Enrique Arus Soler; Raimundo Llanio Navarro; Javier Diaz Elias; Oscar Villa Jiménez; Maria del Rosario Abreu Vazquez

    2009-01-01

    AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical (ascites,encephalopathy and variceal bleeding) and biochemical (serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52- and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups (low risk ≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fit,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values (c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease (MELD) and Child-Pugh (CP) scores for 12-,52- and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow (H-L) statistic revealed that the biochemical and clinical model (H-L,4.69) is better calibrated than MELD (H-L,17.06) and CP (H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups (low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.

  3. Modeling photosynthesis of discontinuous plant canopies by linking the Geometric Optical Radiative Transfer model with biochemical processes

    Science.gov (United States)

    Xin, Q.; Gong, P.; Li, W.

    2015-06-01

    Modeling vegetation photosynthesis is essential for understanding carbon exchanges between terrestrial ecosystems and the atmosphere. The radiative transfer process within plant canopies is one of the key drivers that regulate canopy photosynthesis. Most vegetation cover consists of discrete plant crowns, of which the physical observation departs from the underlying assumption of a homogenous and uniform medium in classic radiative transfer theory. Here we advance the Geometric Optical Radiative Transfer (GORT) model to simulate photosynthesis activities for discontinuous plant canopies. We separate radiation absorption into two components that are absorbed by sunlit and shaded leaves, and derive analytical solutions by integrating over the canopy layer. To model leaf-level and canopy-level photosynthesis, leaf light absorption is then linked to the biochemical process of gas diffusion through leaf stomata. The canopy gap probability derived from GORT differs from classic radiative transfer theory, especially when the leaf area index is high, due to leaf clumping effects. Tree characteristics such as tree density, crown shape, and canopy length affect leaf clumping and regulate radiation interception. Modeled gross primary production (GPP) for two deciduous forest stands could explain more than 80% of the variance of flux tower measurements at both near hourly and daily timescales. We demonstrate that ambient CO2 concentrations influence daytime vegetation photosynthesis, which needs to be considered in biogeochemical models. The proposed model is complementary to classic radiative transfer theory and shows promise in modeling the radiative transfer process and photosynthetic activities over discontinuous forest canopies.

  4. An integrated network model of psychotic symptoms.

    Science.gov (United States)

    Looijestijn, Jasper; Blom, Jan Dirk; Aleman, André; Hoek, Hans W; Goekoop, Rutger

    2015-12-01

    The full body of research on the nature of psychosis and its determinants indicates that a considerable number of factors are relevant to the development of hallucinations, delusions, and other positive symptoms, ranging from neurodevelopmental parameters and altered connectivity of brain regions to impaired cognitive functioning and social factors. We aimed to integrate these factors in a single mathematical model based on network theory. At the microscopic level this model explains positive symptoms of psychosis in terms of experiential equivalents of robust, high-frequency attractor states of neural networks. At the mesoscopic level it explains them in relation to global brain states, and at the macroscopic level in relation to social-network structures and dynamics. Due to the scale-free nature of biological networks, all three levels are governed by the same general laws, thereby allowing for an integrated model of biological, psychological, and social phenomena involved in the mediation of positive symptoms of psychosis. This integrated network model of psychotic symptoms (INMOPS) is described together with various possibilities for application in clinical practice. PMID:26432501

  5. An integrated network model of psychotic symptoms.

    Science.gov (United States)

    Looijestijn, Jasper; Blom, Jan Dirk; Aleman, André; Hoek, Hans W; Goekoop, Rutger

    2015-12-01

    The full body of research on the nature of psychosis and its determinants indicates that a considerable number of factors are relevant to the development of hallucinations, delusions, and other positive symptoms, ranging from neurodevelopmental parameters and altered connectivity of brain regions to impaired cognitive functioning and social factors. We aimed to integrate these factors in a single mathematical model based on network theory. At the microscopic level this model explains positive symptoms of psychosis in terms of experiential equivalents of robust, high-frequency attractor states of neural networks. At the mesoscopic level it explains them in relation to global brain states, and at the macroscopic level in relation to social-network structures and dynamics. Due to the scale-free nature of biological networks, all three levels are governed by the same general laws, thereby allowing for an integrated model of biological, psychological, and social phenomena involved in the mediation of positive symptoms of psychosis. This integrated network model of psychotic symptoms (INMOPS) is described together with various possibilities for application in clinical practice.

  6. Modelling Users` Trust in Online Social Networks

    Directory of Open Access Journals (Sweden)

    Iacob Cătoiu

    2014-02-01

    Full Text Available Previous studies (McKnight, Lankton and Tripp, 2011; Liao, Lui and Chen, 2011 have shown the crucial role of trust when choosing to disclose sensitive information online. This is the case of online social networks users, who must disclose a certain amount of personal data in order to gain access to these online services. Taking into account privacy calculus model and the risk/benefit ratio, we propose a model of users’ trust in online social networks with four variables. We have adapted metrics for the purpose of our study and we have assessed their reliability and validity. We use a Partial Least Squares (PLS based structural equation modelling analysis, which validated all our initial assumptions, indicating that our three predictors (privacy concerns, perceived benefits and perceived risks explain 48% of the variation of users’ trust in online social networks, the resulting variable of our study. We also discuss the implications and further research opportunities of our study.

  7. The Kuramoto model in complex networks

    CERN Document Server

    Rodrigues, Francisco A; Ji, Peng; Kurths, Jürgen

    2016-01-01

    Synchronization of an ensemble of oscillators is an emergent phenomenon present in several complex systems, ranging from social and physical to biological and technological systems. The most successful approach to describe how coherent behavior emerges in these complex systems is given by the paradigmatic Kuramoto model. This model has been traditionally studied in complete graphs. However, besides being intrinsically dynamical, complex systems present very heterogeneous structure, which can be represented as complex networks. This report is dedicated to review main contributions in the field of synchronization in networks of Kuramoto oscillators. In particular, we provide an overview of the impact of network patterns on the local and global dynamics of coupled phase oscillators. We cover many relevant topics, which encompass a description of the most used analytical approaches and the analysis of several numerical results. Furthermore, we discuss recent developments on variations of the Kuramoto model in net...

  8. Research on Modeling of Genetic Networks Based on Information Measurement

    Institute of Scientific and Technical Information of China (English)

    ZHANG Guo-wei; SHAO Shi-huang; ZHANG Ying; LI Hai-ying

    2006-01-01

    As the basis of network of biology organism, the genetic network is concerned by many researchers.Current modeling methods to genetic network, especially the Boolean networks modeling method are analyzed. For modeling the genetic network, the information theory is proposed to mining the relations between elements in network. Through calculating the values of information entropy and mutual entropy in a case, the effectiveness of the method is verified.

  9. Features and heterogeneities in growing network models

    Science.gov (United States)

    Ferretti, Luca; Cortelezzi, Michele; Yang, Bin; Marmorini, Giacomo; Bianconi, Ginestra

    2012-06-01

    Many complex networks from the World Wide Web to biological networks grow taking into account the heterogeneous features of the nodes. The feature of a node might be a discrete quantity such as a classification of a URL document such as personal page, thematic website, news, blog, search engine, social network, etc., or the classification of a gene in a functional module. Moreover the feature of a node can be a continuous variable such as the position of a node in the embedding space. In order to account for these properties, in this paper we provide a generalization of growing network models with preferential attachment that includes the effect of heterogeneous features of the nodes. The main effect of heterogeneity is the emergence of an “effective fitness” for each class of nodes, determining the rate at which nodes acquire new links. The degree distribution exhibits a multiscaling behavior analogous to the the fitness model. This property is robust with respect to variations in the model, as long as links are assigned through effective preferential attachment. Beyond the degree distribution, in this paper we give a full characterization of the other relevant properties of the model. We evaluate the clustering coefficient and show that it disappears for large network size, a property shared with the Barabási-Albert model. Negative degree correlations are also present in this class of models, along with nontrivial mixing patterns among features. We therefore conclude that both small clustering coefficients and disassortative mixing are outcomes of the preferential attachment mechanism in general growing networks.

  10. String networks with junctions in competition models

    CERN Document Server

    Avelino, P P; Losano, L; Menezes, J; de Oliveira, B F

    2016-01-01

    In this work we give specific examples of competition models, with six and eight species, whose three-dimensional dynamics naturally leads to the formation of string networks with junctions, associated with regions that have a high concentration of enemy species. We study the two- and three-dimensional evolution of such networks, both using stochastic network and mean field theory simulations. If the predation, reproduction and mobility probabilities do not vary in space and time, we find that the networks attain scaling regimes with a characteristic length roughly proportional to $t^{1/2}$, where $t$ is the physical time, thus showing that the presence of junctions, on its own, does not have a significant impact on their scaling properties.

  11. Modeling the emergence of circadian rhythms in a clock neuron network.

    Directory of Open Access Journals (Sweden)

    Luis Diambra

    Full Text Available Circadian rhythms in pacemaker cells persist for weeks in constant darkness, while in other types of cells the molecular oscillations that underlie circadian rhythms damp rapidly under the same conditions. Although much progress has been made in understanding the biochemical and cellular basis of circadian rhythms, the mechanisms leading to damped or self-sustained oscillations remain largely unknown. There exist many mathematical models that reproduce the circadian rhythms in the case of a single cell of the Drosophila fly. However, not much is known about the mechanisms leading to coherent circadian oscillation in clock neuron networks. In this work we have implemented a model for a network of interacting clock neurons to describe the emergence (or damping of circadian rhythms in Drosophila fly, in the absence of zeitgebers. Our model consists of an array of pacemakers that interact through the modulation of some parameters by a network feedback. The individual pacemakers are described by a well-known biochemical model for circadian oscillation, to which we have added degradation of PER protein by light and multiplicative noise. The network feedback is the PER protein level averaged over the whole network. In particular, we have investigated the effect of modulation of the parameters associated with (i the control of net entrance of PER into the nucleus and (ii the non-photic degradation of PER. Our results indicate that the modulation of PER entrance into the nucleus allows the synchronization of clock neurons, leading to coherent circadian oscillations under constant dark condition. On the other hand, the modulation of non-photic degradation cannot reset the phases of individual clocks subjected to intrinsic biochemical noise.

  12. Unsupervised model compression for multilayer bootstrap networks

    OpenAIRE

    ZHANG, XIAO-LEI

    2015-01-01

    Recently, multilayer bootstrap network (MBN) has demonstrated promising performance in unsupervised dimensionality reduction. It can learn compact representations in standard data sets, i.e. MNIST and RCV1. However, as a bootstrap method, the prediction complexity of MBN is high. In this paper, we propose an unsupervised model compression framework for this general problem of unsupervised bootstrap methods. The framework compresses a large unsupervised bootstrap model into a small model by ta...

  13. A Model for Telestrok Network Evaluation

    DEFF Research Database (Denmark)

    Storm, Anna; Günzel, Franziska; Theiss, Stephan

    2011-01-01

    was developed from the third-party payer perspective. In principle, it enables telestroke networks to conduct cost-effectiveness studies, because the majority of the required data can be extracted from health insurance companies’ databases and the telestroke network itself. The model presents a basis...... analysis lacking, current telestroke reimbursement by third-party payers is limited to special contracts and not included in the regular billing system. Based on a systematic literature review and expert interviews with health care economists, third-party payers and neurologists, a Markov model...

  14. A network biology model of micronutrient related health

    NARCIS (Netherlands)

    Ommen, B. van; Fairweather-Tait, S.; Freidig, A.; Kardinaal, A.; Scalbert, A.; Wopereis, S.

    2008-01-01

    Micronutrients are involved in specific biochemical pathways and have dedicated functions in the body, but they are also interconnected in complex metabolic networks, such as oxidative-reductive and inflammatory pathways and hormonal regulation, in which the overarching function is to optimise healt

  15. Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

    CERN Document Server

    Santi, Paolo

    2012-01-01

    Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

  16. Security Modeling on the Supply Chain Networks

    Directory of Open Access Journals (Sweden)

    Marn-Ling Shing

    2007-10-01

    Full Text Available In order to keep the price down, a purchaser sends out the request for quotation to a group of suppliers in a supply chain network. The purchaser will then choose a supplier with the best combination of price and quality. A potential supplier will try to collect the related information about other suppliers so he/she can offer the best bid to the purchaser. Therefore, confidentiality becomes an important consideration for the design of a supply chain network. Chen et al. have proposed the application of the Bell-LaPadula model in the design of a secured supply chain network. In the Bell-LaPadula model, a subject can be in one of different security clearances and an object can be in one of various security classifications. All the possible combinations of (Security Clearance, Classification pair in the Bell-LaPadula model can be thought as different states in the Markov Chain model. This paper extends the work done by Chen et al., provides more details on the Markov Chain model and illustrates how to use it to monitor the security state transition in the supply chain network.

  17. An evolving model of online bipartite networks

    Science.gov (United States)

    Zhang, Chu-Xu; Zhang, Zi-Ke; Liu, Chuang

    2013-12-01

    Understanding the structure and evolution of online bipartite networks is a significant task since they play a crucial role in various e-commerce services nowadays. Recently, various attempts have been tried to propose different models, resulting in either power-law or exponential degree distributions. However, many empirical results show that the user degree distribution actually follows a shifted power-law distribution, the so-called Mandelbrot’s law, which cannot be fully described by previous models. In this paper, we propose an evolving model, considering two different user behaviors: random and preferential attachment. Extensive empirical results on two real bipartite networks, Delicious and CiteULike, show that the theoretical model can well characterize the structure of real networks for both user and object degree distributions. In addition, we introduce a structural parameter p, to demonstrate that the hybrid user behavior leads to the shifted power-law degree distribution, and the region of power-law tail will increase with the increment of p. The proposed model might shed some lights in understanding the underlying laws governing the structure of real online bipartite networks.

  18. Distributed Bayesian Networks for User Modeling

    DEFF Research Database (Denmark)

    Tedesco, Roberto; Dolog, Peter; Nejdl, Wolfgang;

    2006-01-01

    The World Wide Web is a popular platform for providing eLearning applications to a wide spectrum of users. However – as users differ in their preferences, background, requirements, and goals – applications should provide personalization mechanisms. In the Web context, user models used...... by such adaptive applications are often partial fragments of an overall user model. The fragments have then to be collected and merged into a global user profile. In this paper we investigate and present algorithms able to cope with distributed, fragmented user models – based on Bayesian Networks – in the context...... of Web-based eLearning platforms. The scenario we are tackling assumes learners who use several systems over time, which are able to create partial Bayesian Networks for user models based on the local system context. In particular, we focus on how to merge these partial user models. Our merge mechanism...

  19. Network Reconstruction with Realistic Models

    OpenAIRE

    Grzegorczyk, Marco; Aderhold, Andrej; Husmeier, Dirk

    2015-01-01

    We extend a recently proposed gradient-matching method for inferring interactions in complex systems described by differential equations in various respects: improved gradient inference, evaluation of the influence of the prior on kinetic parameters, comparative evaluation of two model selection paradigms: marginal likelihood versus DIC (divergence information criterion), comparative evaluation of different numerical procedures for computing the marginal likelihood, extension of the methodolo...

  20. An autocatalytic network model for stock markets

    Science.gov (United States)

    Caetano, Marco Antonio Leonel; Yoneyama, Takashi

    2015-02-01

    The stock prices of companies with businesses that are closely related within a specific sector of economy might exhibit movement patterns and correlations in their dynamics. The idea in this work is to use the concept of autocatalytic network to model such correlations and patterns in the trends exhibited by the expected returns. The trends are expressed in terms of positive or negative returns within each fixed time interval. The time series derived from these trends is then used to represent the movement patterns by a probabilistic boolean network with transitions modeled as an autocatalytic network. The proposed method might be of value in short term forecasting and identification of dependencies. The method is illustrated with a case study based on four stocks of companies in the field of natural resource and technology.

  1. Delivery Time Reliability Model of Logistics Network

    Directory of Open Access Journals (Sweden)

    Liusan Wu

    2013-01-01

    Full Text Available Natural disasters like earthquake and flood will surely destroy the existing traffic network, usually accompanied by delivery delay or even network collapse. A logistics-network-related delivery time reliability model defined by a shortest-time entropy is proposed as a means to estimate the actual delivery time reliability. The less the entropy is, the stronger the delivery time reliability remains, and vice versa. The shortest delivery time is computed separately based on two different assumptions. If a path is concerned without capacity restriction, the shortest delivery time is positively related to the length of the shortest path, and if a path is concerned with capacity restriction, a minimax programming model is built to figure up the shortest delivery time. Finally, an example is utilized to confirm the validity and practicality of the proposed approach.

  2. International Trade: a Reinforced Urn Network Model

    CERN Document Server

    Peluso, Stefano; Muliere, Pietro; Lomi, Alessandro

    2016-01-01

    We propose a unified modelling framework that theoretically justifies the main empirical regularities characterizing the international trade network. Each country is associated to a Polya urn whose composition controls the propensity of the country to trade with other countries. The urn composition is updated through the walk of the Reinforced Urn Process of Muliere et al. (2000). The model implies a local preferential attachment scheme and a power law right tail behaviour of bilateral trade flows. Different assumptions on the urns' reinforcement parameters account for local clustering, path-shortening and sparsity. Likelihood-based estimation approaches are facilitated by feasible likelihood analytical derivation in various network settings. A simulated example and the empirical results on the international trade network are discussed.

  3. Bayesian Network Based XP Process Modelling

    Directory of Open Access Journals (Sweden)

    Mohamed Abouelela

    2010-07-01

    Full Text Available A Bayesian Network based mathematical model has been used for modelling Extreme Programmingsoftware development process. The model is capable of predicting the expected finish time and theexpected defect rate for each XP release. Therefore, it can be used to determine the success/failure of anyXP Project. The model takes into account the effect of three XP practices, namely: Pair Programming,Test Driven Development and Onsite Customer practices. The model’s predictions were validated againsttwo case studies. Results show the precision of our model especially in predicting the project finish time.

  4. Validation of MIKE 11 Model Simulated Data for Biochemical and Chemical Oxygen Demands Transport

    Directory of Open Access Journals (Sweden)

    Mahdieh Eisakhani

    2012-01-01

    Full Text Available Problem statement: The aim of the study was to model the discharge, biochemical and chemical oxygen demands (BOD and COD loads in each cross section of Bertam River in Cameron Highlands, Malaysia. Cameron Highlands form the headwater catchment for two major rivers of the lowlands; Pahang River and Perak River. On the other hand, Cameron Highlands is undergoing rapid development as a popular tourist destination and an area exploited for growing of temperature vegetables, fruits and flowers. It is also a mountainous area subjected to torrential tropical showers. The condition of Bertam River as one of the main rivers in Cameron Highlands has degraded over the years in terms of water pollution and river environment. Approach: Therefore, MIKE 11 a one-dimensional hydrodynamic simulation program was utilized to model stream flow transport and water quality processing in the river system. The model was used to generate the river outflow and simulate BOD and COD concentrations in each cross section of Bertam River. Hydrodynamic Module (HD which uses an implicit, finite difference solver was applied to calculate water level and flow for the river. Next, Rainfall-Runoff Module (RR which is include unit hydrograph method and lumped conceptual continuous hydrological model was used to combine the meteorological data of the study area to MIKE 11 simulation system. Finally, Advection-Dispersion Module (AD was used for transported BOD and COD concentrations calculation. Results: Water quality results show the BOD5 varies from 1-2 mg L-1 during pre-monsoon and from 4-10 mg L-1 during post-monsoon. The COD between 39-49 mg L-1 was observed during High Water Flow (HWF. Much lower concentration was detected during Average Water Flow (AWF which was between 10-14 mg L-1. The comparative analysis between measured and simulated data showed that MIKE 11 is able to predict sufficiently accurate BOD and COD loads at the catchment outlet especially during AWF. Conclusion

  5. Assessing seasonality of biochemical CO2 exchange model parameters from micrometeorological flux observations at boreal coniferous forest

    Directory of Open Access Journals (Sweden)

    T. Vesala

    2008-12-01

    Full Text Available The seasonality of the NEE of the northern boreal coniferous forests was investigated by means of inversion modelling using eddy covariance data. Eddy covariance data was used to optimize the biochemical model parameters. Our study sites consisted of three Scots pine (l. Pinus sylvestris forests and one Norway spruce (l. Picea abies forest that were located in Finland and Sweden. We obtained temperature and seasonal dependence for the biochemical model parameters: the maximum rate of carboxylation (Vc(max and the maximum rate of electron transport (Jmax. Both of the parameters were optimized without assumptions about their mutual magnitude. The values obtained for the biochemical model parameters were similar at all the sites during summer time. To describe seasonality, different temperature fits were made for the spring, summer and autumn periods. During summer, average Jmax across the sites was 54.0 μmol m−2 s−1 (variance 31.2 μmol m−2 s−1 and Vc(max was 12.0 μmol m−2 s−1 (variance 6.6 μmol m−2 s−1 at 17°C. The sensitivity of the model to LAI and atmospheric soil water stress was also studied. The impact of seasonality on annual GPP was 17% when only summertime parameterization was used throughout the year compared to seasonally changing parameterizations.

  6. Keystone Business Models for Network Security Processors

    Directory of Open Access Journals (Sweden)

    Arthur Low

    2013-07-01

    Full Text Available Network security processors are critical components of high-performance systems built for cybersecurity. Development of a network security processor requires multi-domain experience in semiconductors and complex software security applications, and multiple iterations of both software and hardware implementations. Limited by the business models in use today, such an arduous task can be undertaken only by large incumbent companies and government organizations. Neither the “fabless semiconductor” models nor the silicon intellectual-property licensing (“IP-licensing” models allow small technology companies to successfully compete. This article describes an alternative approach that produces an ongoing stream of novel network security processors for niche markets through continuous innovation by both large and small companies. This approach, referred to here as the "business ecosystem model for network security processors", includes a flexible and reconfigurable technology platform, a “keystone” business model for the company that maintains the platform architecture, and an extended ecosystem of companies that both contribute and share in the value created by innovation. New opportunities for business model innovation by participating companies are made possible by the ecosystem model. This ecosystem model builds on: i the lessons learned from the experience of the first author as a senior integrated circuit architect for providers of public-key cryptography solutions and as the owner of a semiconductor startup, and ii the latest scholarly research on technology entrepreneurship, business models, platforms, and business ecosystems. This article will be of interest to all technology entrepreneurs, but it will be of particular interest to owners of small companies that provide security solutions and to specialized security professionals seeking to launch their own companies.

  7. A Model of Mental State Transition Network

    Science.gov (United States)

    Xiang, Hua; Jiang, Peilin; Xiao, Shuang; Ren, Fuji; Kuroiwa, Shingo

    Emotion is one of the most essential and basic attributes of human intelligence. Current AI (Artificial Intelligence) research is concentrating on physical components of emotion, rarely is it carried out from the view of psychology directly(1). Study on the model of artificial psychology is the first step in the development of human-computer interaction. As affective computing remains unpredictable, creating a reasonable mental model becomes the primary task for building a hybrid system. A pragmatic mental model is also the fundament of some key topics such as recognition and synthesis of emotions. In this paper a Mental State Transition Network Model(2) is proposed to detect human emotions. By a series of psychological experiments, we present a new way to predict coming human's emotions depending on the various current emotional states under various stimuli. Besides, people in different genders and characters are taken into consideration in our investigation. According to the psychological experiments data derived from 200 questionnaires, a Mental State Transition Network Model for describing the transitions in distribution among the emotions and relationships between internal mental situations and external are concluded. Further more the coefficients of the mental transition network model were achieved. Comparing seven relative evaluating experiments, an average precision rate of 0.843 is achieved using a set of samples for the proposed model.

  8. The Kuramoto model in complex networks

    Science.gov (United States)

    Rodrigues, Francisco A.; Peron, Thomas K. DM.; Ji, Peng; Kurths, Jürgen

    2016-01-01

    Synchronization of an ensemble of oscillators is an emergent phenomenon present in several complex systems, ranging from social and physical to biological and technological systems. The most successful approach to describe how coherent behavior emerges in these complex systems is given by the paradigmatic Kuramoto model. This model has been traditionally studied in complete graphs. However, besides being intrinsically dynamical, complex systems present very heterogeneous structure, which can be represented as complex networks. This report is dedicated to review main contributions in the field of synchronization in networks of Kuramoto oscillators. In particular, we provide an overview of the impact of network patterns on the local and global dynamics of coupled phase oscillators. We cover many relevant topics, which encompass a description of the most used analytical approaches and the analysis of several numerical results. Furthermore, we discuss recent developments on variations of the Kuramoto model in networks, including the presence of noise and inertia. The rich potential for applications is discussed for special fields in engineering, neuroscience, physics and Earth science. Finally, we conclude by discussing problems that remain open after the last decade of intensive research on the Kuramoto model and point out some promising directions for future research.

  9. Neural Network Model of Memory Retrieval.

    Science.gov (United States)

    Recanatesi, Stefano; Katkov, Mikhail; Romani, Sandro; Tsodyks, Misha

    2015-01-01

    Human memory can store large amount of information. Nevertheless, recalling is often a challenging task. In a classical free recall paradigm, where participants are asked to repeat a briefly presented list of words, people make mistakes for lists as short as 5 words. We present a model for memory retrieval based on a Hopfield neural network where transition between items are determined by similarities in their long-term memory representations. Meanfield analysis of the model reveals stable states of the network corresponding (1) to single memory representations and (2) intersection between memory representations. We show that oscillating feedback inhibition in the presence of noise induces transitions between these states triggering the retrieval of different memories. The network dynamics qualitatively predicts the distribution of time intervals required to recall new memory items observed in experiments. It shows that items having larger number of neurons in their representation are statistically easier to recall and reveals possible bottlenecks in our ability of retrieving memories. Overall, we propose a neural network model of information retrieval broadly compatible with experimental observations and is consistent with our recent graphical model (Romani et al., 2013). PMID:26732491

  10. Modelling crime linkage with Bayesian networks

    NARCIS (Netherlands)

    J. de Zoete; M. Sjerps; D. Lagnado; N. Fenton

    2015-01-01

    When two or more crimes show specific similarities, such as a very distinct modus operandi, the probability that they were committed by the same offender becomes of interest. This probability depends on the degree of similarity and distinctiveness. We show how Bayesian networks can be used to model

  11. In vivo diagnosis of colonic precancer and cancer using near-infrared autofluorescence spectroscopy and biochemical modeling

    Science.gov (United States)

    Shao, Xiaozhuo; Zheng, Wei; Huang, Zhiwei

    2011-06-01

    The aim of this study is to evaluate the biochemical foundation and clinical capability of an image-guided near-infrared (NIR) autofluorescence (AF) spectroscopy technique for in vivo diagnosis of colonic malignancies during clinical colonoscopy. A novel endoscopic fiber-optic AF system was utilized for in vivo NIR AF measurements at 785 nm excitation. A total of 263 in vivo NIR AF spectra of colonic tissues were measured from 100 patients, in which 164 spectra were from benign tissue (116 normal and 48 hyperplastic polyps), 34 spectra were from precancer (adenomatous polyps), and 65 spectra were from cancer. The non-negativity constrained least squares minimization biochemical modeling was explored to estimate the biochemical compositions of colonic tissue using nine basis reference spectra from the representative biochemicals (i.e., collagen I, elastin, β-nicotinamide adenine dinucleotide, flavin adenine dinucleotide, L-tryptophan, hematoporphyrin, 4-pyridoxic acid, pyridoxal 5'-phosphate, and water) associated with structural or cellular metabolic progression in colonic precancer and cancer. High-quality in vivo NIR AF spectra in the spectral range of 810 to 1000 nm were acquired from colonic benign, precancerous, and cancerous mucosa under white-light reflectance endoscopic imaging guidance. Partial least squares discriminant analysis, together with the leave-one tissue site-out, cross validation on in vivo NIR AF spectra yields diagnostic sensitivities of 85.4%, 76.5%, and 84.6%, and specificities of 89.9%, 93.4%, and 91.4%, respectively, for classification of benign, precancer, and cancer in the colon. This work demonstrates that image-guided NIR AF spectroscopy in conjunction with biochemical modeling has promising potential for improving in vivo detection and diagnosis of colonic precancer and cancer during clinical colonoscopic screening.

  12. Unified Model for Generation Complex Networks with Utility Preferential Attachment

    Institute of Scientific and Technical Information of China (English)

    WU Jian-Jun; GAO Zi-You; SUN Hui-Jun

    2006-01-01

    In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics ofthis new network are given.

  13. Hybrid simulation models of production networks

    CERN Document Server

    Kouikoglou, Vassilis S

    2001-01-01

    This book is concerned with a most important area of industrial production, that of analysis and optimization of production lines and networks using discrete-event models and simulation. The book introduces a novel approach that combines analytic models and discrete-event simulation. Unlike conventional piece-by-piece simulation, this method observes a reduced number of events between which the evolution of the system is tracked analytically. Using this hybrid approach, several models are developed for the analysis of production lines and networks. The hybrid approach combines speed and accuracy for exceptional analysis of most practical situations. A number of optimization problems, involving buffer design, workforce planning, and production control, are solved through the use of hybrid models.

  14. Network Coding Capacity of Random Wireless Networks under a SINR Model

    OpenAIRE

    Kong, Zhenning; Aly, Salah A.; Soljanin, Emina; Yeh, Edmund M.; Klappenecker, Andreas

    2008-01-01

    Previous work on network coding capacity for random wired and wireless networks have focused on the case where the capacities of links in the network are independent. In this paper, we consider a more realistic model, where wireless networks are modelled by random geometric graphs with interference and noise. In this model, the capacities of links are not independent. By employing coupling and martingale methods, we show that, under mild conditions, the network coding capacity for random wire...

  15. Modeling Multistandard Wireless Networks in OPNET

    DEFF Research Database (Denmark)

    Zakrzewska, Anna; Berger, Michael Stübert; Ruepp, Sarah Renée

    2011-01-01

    Future wireless communication is emerging towards one heterogeneous platform. In this new environment wireless access will be provided by multiple radio technologies that are cooperating and complementing one another. The paper investigates the possibilities of developing such a multistandard sys...... system using OPNET Modeler. A network model consisting of LTE interworking with WLAN and WiMAX is considered from the radio resource management perspective. In particular, implementing a joint packet scheduler across multiple systems is discussed more in detail....

  16. XY model in small-world networks

    OpenAIRE

    Kim, Beom Jun; Hong, H.; Holme, Petter; Jeon, Gun Sang; Minnhagen, Petter; Choi, M. Y.

    2001-01-01

    The phase transition in the XY model on one-dimensional small-world networks is investigated by means of Monte-Carlo simulations. It is found that long-range order is present at finite temperatures, even for very small values of the rewiring probability, suggesting a finite-temperature transition for any nonzero rewiring probability. Nature of the phase transition is discussed in comparison with the globally-coupled XY model.

  17. Constructing a fish metabolic network model

    OpenAIRE

    Li, S.; Pozhitkov, A.; R. Ryan; Manning, C; Brown-Peterson, N.; Brouwer, M

    2010-01-01

    We report the construction of a genome-wide fish metabolic network model, MetaFishNet, and its application to analyzing high throughput gene expression data. This model is a stepping stone to broader applications of fish systems biology, for example by guiding study design through comparison with human metabolism and the integration of multiple data types. MetaFishNet resources, including a pathway enrichment analysis tool, are accessible at http://metafishnet.appspot.com.

  18. Neuroprotective effect of edaravone in experimental glaucoma model in rats: a immunofluorescence and biochemical analysis

    Institute of Scientific and Technical Information of China (English)

    Arzu; Toruk; Aksar; Nursen; Yuksel; Mustafa; Gok; Mustafa; Cekmen; Yusuf; Caglar

    2015-01-01

    AIM: To evaluate the neuroprotective activity of systemically administered edaravone in early and late stage of experimental glaucoma in rats.METHODS: In this study, 60 Wistar albino rats were used. Experimental glaucoma model was created by injecting hyaluronic acid to the anterior chamber once a week for 6wk in 46 of 60 subjects. Fourteen subjects without any medication were included as control group.Edaravone administered intraperitoneally 3 mg/kg/d to the 15 of 30 subjects starting at the onset of glaucoma induction and also administered intraperitoneally3 mg/kg/d to the other 15 subjects starting at three weeks after the onset of glaucoma induction. The other16 subjects who underwent glaucoma induction was administered any therapy. Retinal ganglion cells(RGCs)have been marked with dextran tetramethylrhodamine(DTMR) retrograde at the end of the sixth week and after48 h, subjects were sacrificed by the method of cardiac perfusion. Alive RGC density was assessed in the wholemount retina. Whole-mount retinal tissues homogenized and nitric oxide(NO), malondialdehyde(MDA) and total antioxidant capacity(TAC) values were measured biochemically.RESULTS: RGCs counted with Image-Pro Plus program, in the treatment group were found to be statistically significantly protected, compared to the glaucoma group(Bonferroni,P <0.05). The neuroprotective activity of edaravone was found to be more influential byadministration at the start of the glaucoma process.Statistically significant lower NO levels were determined in the glaucoma group comparing treatment groups(Bonferroni, P <0.05). MDA levels were found to be highest in untreated glaucoma group, TAC levels were found to be lower in the glaucoma induction groups than the control group(Bonferroni, P <0.05).CONCLUSION: Systemic administration of edaravone in experimental glaucoma showed potent neuroprotective activity. The role of oxidative stress causing RGC damage in glaucoma was supported by this study results.

  19. Modelling dendritic ecological networks in space: anintegrated network perspective

    Science.gov (United States)

    Peterson, Erin E.; Ver Hoef, Jay M.; Isaak, Dan J.; Falke, Jeffrey A.; Fortin, Marie-Josée; Jordon, Chris E.; McNyset, Kristina; Monestiez, Pascal; Ruesch, Aaron S.; Sengupta, Aritra; Som, Nicholas; Steel, E. Ashley; Theobald, David M.; Torgersen, Christian E.; Wenger, Seth J.

    2013-01-01

    Dendritic ecological networks (DENs) are a unique form of ecological networks that exhibit a dendritic network topology (e.g. stream and cave networks or plant architecture). DENs have a dual spatial representation; as points within the network and as points in geographical space. Consequently, some analytical methods used to quantify relationships in other types of ecological networks, or in 2-D space, may be inadequate for studying the influence of structure and connectivity on ecological processes within DENs. We propose a conceptual taxonomy of network analysis methods that account for DEN characteristics to varying degrees and provide a synthesis of the different approaches within

  20. On traffic modelling in GPRS networks

    DEFF Research Database (Denmark)

    Madsen, Tatiana Kozlova; Schwefel, Hans-Peter; Prasad, Ramjee;

    2005-01-01

    Optimal design and dimensioning of wireless data networks, such as GPRS, requires the knowledge of traffic characteristics of different data services. This paper presents an in-detail analysis of an IP-level traffic measurements taken in an operational GPRS network. The data measurements reported...... here are done at the Gi interface. The aim of this paper is to reveal some key statistics of GPRS data applications and to validate if the existing traffic models can adequately describe traffic volume and inter-arrival time distribution for different services. Additionally, we present a method of user...

  1. Dynamical modeling of the cholesterol regulatory pathway with Boolean networks

    Directory of Open Access Journals (Sweden)

    Corcos Laurent

    2008-11-01

    Full Text Available Abstract Background Qualitative dynamics of small gene regulatory networks have been studied in quite some details both with synchronous and asynchronous analysis. However, both methods have their drawbacks: synchronous analysis leads to spurious attractors and asynchronous analysis lacks computational efficiency, which is a problem to simulate large networks. We addressed this question through the analysis of a major biosynthesis pathway. Indeed the cholesterol synthesis pathway plays a pivotal role in dislypidemia and, ultimately, in cancer through intermediates such as mevalonate, farnesyl pyrophosphate and geranyl geranyl pyrophosphate, but no dynamic model of this pathway has been proposed until now. Results We set up a computational framework to dynamically analyze large biological networks. This framework associates a classical and computationally efficient synchronous Boolean analysis with a newly introduced method based on Markov chains, which identifies spurious cycles among the results of the synchronous simulation. Based on this method, we present here the results of the analysis of the cholesterol biosynthesis pathway and its physiological regulation by the Sterol Response Element Binding Proteins (SREBPs, as well as the modeling of the action of statins, inhibitor drugs, on this pathway. The in silico experiments show the blockade of the cholesterol endogenous synthesis by statins and its regulation by SREPBs, in full agreement with the known biochemical features of the pathway. Conclusion We believe that the method described here to identify spurious cycles opens new routes to compute large and biologically relevant models, thanks to the computational efficiency of synchronous simulation. Furthermore, to the best of our knowledge, we present here the first dynamic systems biology model of the human cholesterol pathway and several of its key regulatory control elements, hoping it would provide a good basis to perform in silico

  2. Neural Network Model of memory retrieval

    Directory of Open Access Journals (Sweden)

    Stefano eRecanatesi

    2015-12-01

    Full Text Available Human memory can store large amount of information. Nevertheless, recalling is often achallenging task. In a classical free recall paradigm, where participants are asked to repeat abriefly presented list of words, people make mistakes for lists as short as 5 words. We present amodel for memory retrieval based on a Hopfield neural network where transition between itemsare determined by similarities in their long-term memory representations. Meanfield analysis ofthe model reveals stable states of the network corresponding (1 to single memory representationsand (2 intersection between memory representations. We show that oscillating feedback inhibitionin the presence of noise induces transitions between these states triggering the retrieval ofdifferent memories. The network dynamics qualitatively predicts the distribution of time intervalsrequired to recall new memory items observed in experiments. It shows that items having largernumber of neurons in their representation are statistically easier to recall and reveals possiblebottlenecks in our ability of retrieving memories. Overall, we propose a neural network model ofinformation retrieval broadly compatible with experimental observations and is consistent with ourrecent graphical model (Romani et al., 2013.

  3. Comparison of two different stochastic models for extracting protein regulatory pathways using Bayesian networks.

    Science.gov (United States)

    Grzegorczyk, Marco

    2008-01-01

    Toxicoproteomics integrates traditional toxicology and systems biology and seeks to infer the architecture of biochemical pathways in biological systems that are affected by and respond to chemical and environmental exposures. Different reverse engineering methods for extracting biochemical regulatory networks from data have been proposed and it is important to understand their relative strengths and weaknesses. To shed some light onto this problem, Werhli et al. (2006) cross-compared three widely used methodologies, relevance networks, graphical Gaussian models, and Bayesian networks (BN), on real cytometric and synthetic expression data. This study continues with the evaluation and compares the learning performances of two different stochastic models (BGe and BDe) for BN. Cytometric protein expression data from the RAF-signaling pathway were used for the cross-method comparison. Understanding this pathway is an important task, as it is known that RAF is a critical signaling protein whose deregulation leads to carcinogenesis. When the more flexible BDe model is employed, a data discretization, which usually incurs an inevitable information loss, is needed. However, the results of the study reveal that the BDe model is preferable to the BGe model when a sufficiently large number of observations from the pathway are available. PMID:18569581

  4. A Networks Approach to Modeling Enzymatic Reactions.

    Science.gov (United States)

    Imhof, P

    2016-01-01

    Modeling enzymatic reactions is a demanding task due to the complexity of the system, the many degrees of freedom involved and the complex, chemical, and conformational transitions associated with the reaction. Consequently, enzymatic reactions are not determined by precisely one reaction pathway. Hence, it is beneficial to obtain a comprehensive picture of possible reaction paths and competing mechanisms. By combining individually generated intermediate states and chemical transition steps a network of such pathways can be constructed. Transition networks are a discretized representation of a potential energy landscape consisting of a multitude of reaction pathways connecting the end states of the reaction. The graph structure of the network allows an easy identification of the energetically most favorable pathways as well as a number of alternative routes.

  5. Models for the Generation of Heterogeneous Complex Networks

    OpenAIRE

    Youssef, Bassant El Sayed

    2015-01-01

    Complex networks are composed of a large number of interacting nodes. Examples of complex networks include the topology of the Internet, connections between websites or web pages in the World Wide Web (WWW), and connections between participants in social networks.Due to their ubiquity, modeling complex networks is importantfor answering many research questions that cannot be answered without a mathematical model. For example, mathematical models of complex networks can be used to find the mo...

  6. KSC Centralized Index Model in Complex Network

    Directory of Open Access Journals (Sweden)

    Jian Xu

    2014-05-01

    Full Text Available To dig potential spread nodes in a complex network mainly relies on using centralized indicators such as the node degree, closeness, betweenness and K-shell to evaluate spread node, which causes that the excavation accuracy is not high and adaptability not strong and induces other shortcomings, therefore this paper proposes KSC of centering indicator model. This model not only considers the internal attributes of nodes, but also takes the external attributes of nodes into account, and it finally conducts simulation experiments on propagation through the use of SIR model. The experimental results show that: The proposed algorithm is suitable for a variety of complex networks and it finds better, more promising and more influential dissemination nodes.

  7. The noisy voter model on complex networks

    CERN Document Server

    Carro, Adrián; Miguel, Maxi San

    2016-01-01

    We propose a new analytical method to study stochastic, binary-state models on complex networks. Moving beyond the usual mean-field theories, this alternative approach is based on the introduction of an uncorrelated network approximation, allowing to deal with the network structure as parametric heterogeneity. As an illustration, we study the noisy voter model, a modification of the original voter model including random changes of state. The proposed method is able to unfold the dependence of the model not only on the mean degree (the mean-field prediction) but also on more complex averages over the degree distribution. In particular, we find that the degree heterogeneity ---variance of the underlying degree distribution--- has a strong influence on the location of the critical point of a noise-induced, finite-size transition occurring in the model, on the local ordering of the system, and on the functional form of its temporal correlations. Finally, we show how this latter point opens the possibility of infe...

  8. Discriminating model for diagnosis of basal cell carcinoma and melanoma in vitro based on the Raman spectra of selected biochemicals

    Science.gov (United States)

    Silveira, Landulfo; Silveira, Fabrício Luiz; Bodanese, Benito; Zângaro, Renato Amaro; Pacheco, Marcos Tadeu T.

    2012-07-01

    Raman spectroscopy has been employed to identify differences in the biochemical constitution of malignant [basal cell carcinoma (BCC) and melanoma (MEL)] cells compared to normal skin tissues, with the goal of skin cancer diagnosis. We collected Raman spectra from compounds such as proteins, lipids, and nucleic acids, which are expected to be represented in human skin spectra, and developed a linear least-squares fitting model to estimate the contributions of these compounds to the tissue spectra. We used a set of 145 spectra from biopsy fragments of normal (30 spectra), BCC (96 spectra), and MEL (19 spectra) skin tissues, collected using a near-infrared Raman spectrometer (830 nm, 50 to 200 mW, and 20 s exposure time) coupled to a Raman probe. We applied the best-fitting model to the spectra of biochemicals and tissues, hypothesizing that the relative spectral contribution of each compound to the tissue Raman spectrum changes according to the disease. We verified that actin, collagen, elastin, and triolein were the most important biochemicals representing the spectral features of skin tissues. A classification model applied to the relative contribution of collagen III, elastin, and melanin using Euclidean distance as a discriminator could differentiate normal from BCC and MEL.

  9. Modeling the two-hybrid detector: experimental bias on protein interaction networks.

    Science.gov (United States)

    Stibius, Karin B; Sneppen, Kim

    2007-10-01

    This work was done to investigate the two-hybrid experiment for finding protein-protein interactions to explain the asymmetry found in the experimental data, and to help screen the data for high confidence interactions. By looking at the bait-prey experimental setup the resulting protein interaction network can be examined as a directed network (bait --> prey). We have investigated two possible scenarios for the asymmetry in the directed network by developing a biochemical model for the protein-DNA and protein-protein bindings inside the living yeast. One scenario assumes a background activity of bait proteins acting even without the prey, the other scenario explores the asymmetry in the chemistry associated with the bait being automatically located in the right position on the DNA. We conclude that the latter model gives the best description of the observed asymmetry. PMID:17557786

  10. Approaches to Chemical and Biochemical Information and Signal Processing

    Science.gov (United States)

    Privman, Vladimir

    2012-02-01

    We outline models and approaches for error control required to prevent buildup of noise when ``gates'' and other ``network elements'' based on (bio)chemical reaction processes are utilized to realize stable, scalable networks for information and signal processing. We also survey challenges and possible future research. [4pt] [1] Control of Noise in Chemical and Biochemical Information Processing, V. Privman, Israel J. Chem. 51, 118-131 (2010).[0pt] [2] Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic, V. Privman, J. Halamek, M. A. Arugula, D. Melnikov, V. Bocharova and E. Katz, J. Phys. Chem. B 114, 14103-14109 (2010).[0pt] [3] Towards Biosensing Strategies Based on Biochemical Logic Systems, E. Katz, V. Privman and J. Wang, in: Proc. Conf. ICQNM 2010 (IEEE Comp. Soc. Conf. Publ. Serv., Los Alamitos, California, 2010), pages 1-9.

  11. Evaluation and modeling of biochemical methane potential (BMP) of landfilled solid waste: a pilot scale study

    DEFF Research Database (Denmark)

    Bilgili, M Sinan; Demir, Ahmet; Varank, Gamze

    2009-01-01

    The main goal of this study was to present a comparison of landfill performance with respect to solids decomposition. Biochemical methane potential (BMP) test was used to determine the initial and the remaining CH(4) potentials of solid wastes during 27 months of landfilling operation in two pilot...

  12. Cultured neurons as model systems for biochemical and pharmacological studies on receptors for neurotransmitter amino acids

    DEFF Research Database (Denmark)

    Schousboe, A; Drejer, J; Hansen, Gert Helge;

    1985-01-01

    By the use of primary cultures of neurons consisting of cerebral cortex interneurons or cerebellar granule cells it is possible to study biochemical and pharmacological aspects of receptors for GABA and glutamate. Cerebellar granule cells have been shown to express both high- and low-affinity GAB...

  13. Models and Algorithm for Stochastic Network Designs

    Institute of Scientific and Technical Information of China (English)

    Anthony Chen; Juyoung Kim; Seungjae Lee; Jaisung Choi

    2009-01-01

    The network design problem (NDP) is one of the most difficult and challenging problems in trans-portation. Traditional NDP models are often posed as a deterministic bilevel program assuming that all rele-vant inputs are known with certainty. This paper presents three stochastic models for designing transporta-tion networks with demand uncertainty. These three stochastic NDP models were formulated as the ex-pected value model, chance-constrained model, and dependent-chance model in a bilevel programming framework using different criteria to hedge against demand uncertainty. Solution procedures based on the traffic assignment algorithm, genetic algorithm, and Monte-Cado simulations were developed to solve these stochastic NDP models. The nonlinear and nonconvex nature of the bilevel program was handled by the genetic algorithm and traffic assignment algorithm, whereas the stochastic nature was addressed through simulations. Numerical experiments were conducted to evaluate the applicability of the stochastic NDP models and the solution procedure. Results from the three experiments show that the solution procedures are quite robust to different parameter settings.

  14. Network Strategies in the Voter Model

    CERN Document Server

    Javarone, Marco Alberto

    2013-01-01

    We study a simple voter model with two competing parties. In particular, we represent the case of political elections, where people can choose to support one of the two competitors or to remain neutral. People interact in a social network and their opinion depends on those of their neighbors. Therefore, people may change opinion over time, i.e., they can support one competitor or none. The two competitors try to gain the people's consensus by interacting with their neighbors and also with other people. In particular, competitors define temporal connections, following a strategy, to interact with people they do not know, i.e., with all the people that are not their neighbors. We analyze the proposed model to investigate which network strategies are more advantageous, for the competitors, in order to gain the popular consensus. As result, we found that the best network strategy depends on the topology of the social network. Finally, we investigate how the charisma of competitors affects the outcomes of the prop...

  15. Modelling conflicts with cluster dynamics on networks

    CERN Document Server

    Tadic, Bosiljka

    2010-01-01

    We introduce cluster dynamical models of conflicts in which only the largest cluster can be involved in an action. This mimics the situations in which an attack is planned by a central body, and the largest attack force is used. We study the model in its annealed random graph version, on a fixed network, and on a network evolving through the actions. The sizes of actions are distributed with a power-law tail, however, the exponent is non-universal and depends on the frequency of actions and sparseness of the available connections between units. Allowing the network reconstruction over time in a self-organized manner, e.g., by adding the links based on previous liaisons between units, we find that the power-law exponent depends on the evolution time of the network. Its lower limit is given by the universal value 5/2, derived analytically for the case of random fragmentation processes. In the temporal patterns behind the size of actions we find long-range correlations in the time series of number of clusters an...

  16. Modeling Dynamic Evolution of Online Friendship Network

    Institute of Scientific and Technical Information of China (English)

    吴联仁; 闫强

    2012-01-01

    In this paper,we study the dynamic evolution of friendship network in SNS (Social Networking Site).Our analysis suggests that an individual joining a community depends not only on the number of friends he or she has within the community,but also on the friendship network generated by those friends.In addition,we propose a model which is based on two processes:first,connecting nearest neighbors;second,strength driven attachment mechanism.The model reflects two facts:first,in the social network it is a universal phenomenon that two nodes are connected when they have at least one common neighbor;second,new nodes connect more likely to nodes which have larger weights and interactions,a phenomenon called strength driven attachment (also called weight driven attachment).From the simulation results,we find that degree distribution P(k),strength distribution P(s),and degree-strength correlation are all consistent with empirical data.

  17. Features and heterogeneities in growing network models

    CERN Document Server

    Ferretti, Luca; Yang, Bin; Marmorini, Giacomo; Bianconi, Ginestra

    2011-01-01

    Many complex networks from the World-Wide-Web to biological networks are growing taking into account the heterogeneous features of the nodes. The feature of a node might be a discrete quantity such as a classification of a URL document as personal page, thematic website, news, blog, search engine, social network, ect. or the classification of a gene in a functional module. Moreover the feature of a node can be a continuous variable such as the position of a node in the embedding space. In order to account for these properties, in this paper we provide a generalization of growing network models with preferential attachment that includes the effect of heterogeneous features of the nodes. The main effect of heterogeneity is the emergence of an "effective fitness" for each class of nodes, determining the rate at which nodes acquire new links. Beyond the degree distribution, in this paper we give a full characterization of the other relevant properties of the model. We evaluate the clustering coefficient and show ...

  18. Performance modeling, loss networks, and statistical multiplexing

    CERN Document Server

    Mazumdar, Ravi

    2009-01-01

    This monograph presents a concise mathematical approach for modeling and analyzing the performance of communication networks with the aim of understanding the phenomenon of statistical multiplexing. The novelty of the monograph is the fresh approach and insights provided by a sample-path methodology for queueing models that highlights the important ideas of Palm distributions associated with traffic models and their role in performance measures. Also presented are recent ideas of large buffer, and many sources asymptotics that play an important role in understanding statistical multiplexing. I

  19. Artificial Neural Network Model for Predicting Compressive

    Directory of Open Access Journals (Sweden)

    Salim T. Yousif

    2013-05-01

    Full Text Available   Compressive strength of concrete is a commonly used criterion in evaluating concrete. Although testing of the compressive strength of concrete specimens is done routinely, it is performed on the 28th day after concrete placement. Therefore, strength estimation of concrete at early time is highly desirable. This study presents the effort in applying neural network-based system identification techniques to predict the compressive strength of concrete based on concrete mix proportions, maximum aggregate size (MAS, and slump of fresh concrete. Back-propagation neural networks model is successively developed, trained, and tested using actual data sets of concrete mix proportions gathered from literature.    The test of the model by un-used data within the range of input parameters shows that the maximum absolute error for model is about 20% and 88% of the output results has absolute errors less than 10%. The parametric study shows that water/cement ratio (w/c is the most significant factor  affecting the output of the model.     The results showed that neural networks has strong potential as a feasible tool for predicting compressive strength of concrete.

  20. Networks in Cell Biology = Modelling cell biology with networks

    OpenAIRE

    Buchanan, Mark; Caldarelli, Guido; De Los Rios, Paolo; Rao, Francesco; Vendruscolo, M.

    2010-01-01

    The science of complex biological networks is transforming research in areas ranging from evolutionary biology to medicine. This is the first book on the subject, providing a comprehensive introduction to complex network science and its biological applications. With contributions from key leaders in both network theory and modern cell biology, this book discusses the network science that is increasingly foundational for systems biology and the quantitative understanding of living systems. It ...

  1. New Federated Collaborative Networked Organization Model (FCNOM

    Directory of Open Access Journals (Sweden)

    Morcous M. Yassa

    2012-01-01

    Full Text Available Formation of Collaborative Networked Organization (CNO usually comes upon expected business opportunities and needs huge of negotiation during its lifecycle, especially to increase the Dynamic Virtual Organization (DVO configuration automation. Decision makers need more comprehensive information about CNO system to support their decisions. Unfortunately, there is no single formal modeling, tool, approach or any comprehensive methodology that covers all perspectives. In spite of there are some approaches to model CNO have been existed, these approaches model the CNO either with respect to the technology, or business without considering organizational behavior, federation modeling, and external environments. The aim of this paper is to propose an integrated framework that combines the existed modeling perspectives, as well as, proposes new ones. Also, it provides clear CNO boundaries. By using this approach the view of CNO environment becomes clear and unified. Also, it minimizes the negotiations within CNO components during its life cycle, supports DVO configuration automation, as well as, helps decision making for DVO, and achieves harmonization between CNO partners. The proposed FCNOM utilizes CommonKADS methodology organization model for describing CNO components. Insurance Collaborative Network has been used as an example to proof the proposed FCNOM model.

  2. Influence of Deterministic Attachments for Large Unifying Hybrid Network Model

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Large unifying hybrid network model (LUHPM) introduced the deterministic mixing ratio fd on the basis of the harmonious unification hybrid preferential model, to describe the influence of deterministic attachment to the network topology characteristics,

  3. Modelling the influence of land-use changes on biophysical and biochemical interactions at regional and global scales.

    Science.gov (United States)

    Devaraju, N; Bala, G; Nemani, R

    2015-09-01

    Land-use changes since the start of the industrial era account for nearly one-third of the cumulative anthropogenic CO2 emissions. In addition to the greenhouse effect of CO2 emissions, changes in land use also affect climate via changes in surface physical properties such as albedo, evapotranspiration and roughness length. Recent modelling studies suggest that these biophysical components may be comparable with biochemical effects. In regard to climate change, the effects of these two distinct processes may counterbalance one another both regionally and, possibly, globally. In this article, through hypothetical large-scale deforestation simulations using a global climate model, we contrast the implications of afforestation on ameliorating or enhancing anthropogenic contributions from previously converted (agricultural) land surfaces. Based on our review of past studies on this subject, we conclude that the sum of both biophysical and biochemical effects should be assessed when large-scale afforestation is used for countering global warming, and the net effect on global mean temperature change depends on the location of deforestation/afforestation. Further, although biochemical effects trigger global climate change, biophysical effects often cause strong local and regional climate change. The implication of the biophysical effects for adaptation and mitigation of climate change in agriculture and agroforestry sectors is discussed.

  4. Modeling In-Network Aggregation in VANETs

    NARCIS (Netherlands)

    Dietzel, Stefan; Kargl, Frank; Heijenk, Geert; Schaub, Florian

    2011-01-01

    The multitude of applications envisioned for vehicular ad hoc networks requires efficient communication and dissemination mechanisms to prevent network congestion. In-network data aggregation promises to reduce bandwidth requirements and enable scalability in large vehicular networks. However, most

  5. Reliable Communication Models in Interdependent Critical Infrastructure Networks

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sangkeun (Matt) [ORNL; Chinthavali, Supriya [ORNL; Shankar, Mallikarjun [ORNL

    2016-01-01

    Modern critical infrastructure networks are becoming increasingly interdependent where the failures in one network may cascade to other dependent networks, causing severe widespread national-scale failures. A number of previous efforts have been made to analyze the resiliency and robustness of interdependent networks based on different models. However, communication network, which plays an important role in today's infrastructures to detect and handle failures, has attracted little attention in the interdependency studies, and no previous models have captured enough practical features in the critical infrastructure networks. In this paper, we study the interdependencies between communication network and other kinds of critical infrastructure networks with an aim to identify vulnerable components and design resilient communication networks. We propose several interdependency models that systematically capture various features and dynamics of failures spreading in critical infrastructure networks. We also discuss several research challenges in building reliable communication solutions to handle failures in these models.

  6. Arthrofibrotic remodeling after knee replacement surgery, a stress-related disease? - Clinic, biochemical model, therapy, research -

    Science.gov (United States)

    Traut, Philip; Faust, Isabel

    2016-01-01

    Aims and Objectives: The predicted incidence of arthrofibrosis after knee replacement surgery is 5 - 10%. Arthrofibrosis is defined as painful impairment of joint flexibility occurring postoperatively. To counteract symptoms and to accomplish quality standards (E/F 0-0-90) several therapeutic strategies as for instance physiotherapy or mobilization under anaesthesia are applied. Although it is known that mechanical and emotional stress induce myofibroblast differentiation, extracellular matrix (ECM) synthesis and xylosyltransferase (XT) activity, biochemical processes of fibrotic diseases receive little attention in orthopaedics. Until today, neither an adequate disease model nor a diagnostic marker for arthrofibrosis has been described. Materials and Methods: Surgical procedures (e.g. endoprosthesis, cruciate ligament replacement) initiate physiological wound healing and the release of inflammatory mediators from platelets, damaged tissue and other cells of the immune system. Secreted cytokines such as transforming growth factor (TGF-beta 1) or platelet derived growth factor (PDGF) promote myofibroblast proliferation and differentiation. Mechanical strain (stretching exercises with pain inhibition) leads to activation of latent TGF-beta 1, which triggers scarring via ECM/XT synthesis and prevents myofibroblast apoptosis. Our recent study carried out a decreased platelet count in arthrofibrosis patients compared to healthy controls. Thus, an elevated platelet consumption might take place. Analogous to TGF-beta 1, PDGF also inhibits myofibroblast apoptosis and expression of matrix metalloproteinase expression, which degrade ECM. Emotional stress might not only matter in other fibrotic diseases e.g. tako-tsubo cardiomyopathy (TTC) but also in arthrofibrosis. Sympathicotonic destabilization (due to pain, frustration or social burden) results in increased catecholamine synthesis and sympathetic activity. These effects are recognizable by vegetative symptoms (e

  7. Nonequilibrium Zaklan model on Apollonian Networks

    CERN Document Server

    Lima, F W S

    2012-01-01

    The Zaklan model had been proposed and studied recently using the equilibrium Ising model on Square Lattices (SL) by Zaklan et al (2008), near the critical temperature of the Ising model presenting a well-defined phase transition; but on normal and modified Apollonian networks (ANs), Andrade et al. (2005, 2009) studied the equilibrium Ising model. They showed the equilibrium Ising model not to present on ANs a phase transition of the type for the 2D Ising model. Here, within the context of agent-based Monte-Carlo simulations, we study the Zaklan model using the well-known majority-vote model (MVM) with noise and apply it to tax evasion on ANs, to show that differently from the Ising model the MVM on ANs presents a well defined phase transition. To control the tax evasion in the economics model proposed by Zaklan et al, MVM is applied in the neighborhood of the critical noise $q_{c}$ to the Zaklan model. Here we show that the Zaklan model is robust because this can be studied besides using equilibrium dynamics...

  8. Electronic circuits modeling using artificial neural networks

    Directory of Open Access Journals (Sweden)

    Andrejević Miona V.

    2003-01-01

    Full Text Available In this paper artificial neural networks (ANN are applied to modeling of electronic circuits. ANNs are used for application of the black-box modeling concept in the time domain. Modeling process is described, so the topology of the ANN, the testing signal used for excitation, together with the complexity of ANN are considered. The procedure is first exemplified in modeling of resistive circuits. MOS transistor, as a four-terminal device, is modeled. Then nonlinear negative resistive characteristic is modeled in order to be used as a piece-wise linear resistor in Chua's circuit. Examples of modeling nonlinear dynamic circuits are given encompassing a variety of modeling problems. A nonlinear circuit containing quartz oscillator is considered for modeling. Verification of the concept is performed by verifying the ability of the model to generalize i.e. to create acceptable responses to excitations not used during training. Implementation of these models within a behavioral simulator is exemplified. Every model is implemented in realistic surrounding in order to show its interaction, and of course, its usage and purpose.

  9. A proposed "osi based" network troubles identification model

    CERN Document Server

    Kayri, Murat; 10.5121/ijngn.2010.2302

    2010-01-01

    The OSI model, developed by ISO in 1984, attempts to summarize complicated network cases on layers. Moreover, network troubles are expressed by taking the model into account. However, there has been no standardization for network troubles up to now. Network troubles have only been expressed by the name of the related layer. In this paper, it is pointed out that possible troubles on the related layer vary and possible troubles on each layer are categorized for functional network administration and they are standardized in an eligible way. The proposed model for network trouble shooting was developed considering the OSI model.

  10. Mathematical model for spreading dynamics of social network worms

    International Nuclear Information System (INIS)

    In this paper, a mathematical model for social network worm spreading is presented from the viewpoint of social engineering. This model consists of two submodels. Firstly, a human behavior model based on game theory is suggested for modeling and predicting the expected behaviors of a network user encountering malicious messages. The game situation models the actions of a user under the condition that the system may be infected at the time of opening a malicious message. Secondly, a social network accessing model is proposed to characterize the dynamics of network users, by which the number of online susceptible users can be determined at each time step. Several simulation experiments are carried out on artificial social networks. The results show that (1) the proposed mathematical model can well describe the spreading dynamics of social network worms; (2) weighted network topology greatly affects the spread of worms; (3) worms spread even faster on hybrid social networks

  11. A network model for Ebola spreading.

    Science.gov (United States)

    Rizzo, Alessandro; Pedalino, Biagio; Porfiri, Maurizio

    2016-04-01

    The availability of accurate models for the spreading of infectious diseases has opened a new era in management and containment of epidemics. Models are extensively used to plan for and execute vaccination campaigns, to evaluate the risk of international spreadings and the feasibility of travel bans, and to inform prophylaxis campaigns. Even when no specific therapeutical protocol is available, as for the Ebola Virus Disease (EVD), models of epidemic spreading can provide useful insight to steer interventions in the field and to forecast the trend of the epidemic. Here, we propose a novel mathematical model to describe EVD spreading based on activity driven networks (ADNs). Our approach overcomes the simplifying assumption of homogeneous mixing, which is central to most of the mathematically tractable models of EVD spreading. In our ADN-based model, each individual is not bound to contact every other, and its network of contacts varies in time as a function of an activity potential. Our model contemplates the possibility of non-ideal and time-varying intervention policies, which are critical to accurately describe EVD spreading in afflicted countries. The model is calibrated from field data of the 2014 April-to-December spreading in Liberia. We use the model as a predictive tool, to emulate the dynamics of EVD in Liberia and offer a one-year projection, until December 2015. Our predictions agree with the current vision expressed by professionals in the field, who consider EVD in Liberia at its final stage. The model is also used to perform a what-if analysis to assess the efficacy of timely intervention policies. In particular, we show that an earlier application of the same intervention policy would have greatly reduced the number of EVD cases, the duration of the outbreak, and the infrastructures needed for the implementation of the intervention. PMID:26804645

  12. A network model for Ebola spreading.

    Science.gov (United States)

    Rizzo, Alessandro; Pedalino, Biagio; Porfiri, Maurizio

    2016-04-01

    The availability of accurate models for the spreading of infectious diseases has opened a new era in management and containment of epidemics. Models are extensively used to plan for and execute vaccination campaigns, to evaluate the risk of international spreadings and the feasibility of travel bans, and to inform prophylaxis campaigns. Even when no specific therapeutical protocol is available, as for the Ebola Virus Disease (EVD), models of epidemic spreading can provide useful insight to steer interventions in the field and to forecast the trend of the epidemic. Here, we propose a novel mathematical model to describe EVD spreading based on activity driven networks (ADNs). Our approach overcomes the simplifying assumption of homogeneous mixing, which is central to most of the mathematically tractable models of EVD spreading. In our ADN-based model, each individual is not bound to contact every other, and its network of contacts varies in time as a function of an activity potential. Our model contemplates the possibility of non-ideal and time-varying intervention policies, which are critical to accurately describe EVD spreading in afflicted countries. The model is calibrated from field data of the 2014 April-to-December spreading in Liberia. We use the model as a predictive tool, to emulate the dynamics of EVD in Liberia and offer a one-year projection, until December 2015. Our predictions agree with the current vision expressed by professionals in the field, who consider EVD in Liberia at its final stage. The model is also used to perform a what-if analysis to assess the efficacy of timely intervention policies. In particular, we show that an earlier application of the same intervention policy would have greatly reduced the number of EVD cases, the duration of the outbreak, and the infrastructures needed for the implementation of the intervention.

  13. Evolutionary algorithms in genetic regulatory networks model

    CERN Document Server

    Raza, Khalid

    2012-01-01

    Genetic Regulatory Networks (GRNs) plays a vital role in the understanding of complex biological processes. Modeling GRNs is significantly important in order to reveal fundamental cellular processes, examine gene functions and understanding their complex relationships. Understanding the interactions between genes gives rise to develop better method for drug discovery and diagnosis of the disease since many diseases are characterized by abnormal behaviour of the genes. In this paper we have reviewed various evolutionary algorithms-based approach for modeling GRNs and discussed various opportunities and challenges.

  14. A Trust Evaluation Model for Industrial Control Ethernet Network

    Directory of Open Access Journals (Sweden)

    ZHOU Sen-xin

    2011-10-01

    Full Text Available Industrial control ethernet networks are more impotant in connecting with equipments each other of enterprise comprehensive automation and integrating information. With the explosive growth of network techniques, the traditional control networks can no longer satisfy the security demands on network connectivity, data storage and information exchanges.New types of networks emerged in recent years in order to provide solutions for the increasing requirements on networked services. We propose a trust evaluation model for industrial control ethernet network . Our study shows the importance and necessity of applying theoretical analyses to understand the complex characteristics of trusted industrial control ethernet networks.

  15. Complex networks-based energy-efficient evolution model for wireless sensor networks

    International Nuclear Information System (INIS)

    Based on complex networks theory, we present two self-organized energy-efficient models for wireless sensor networks in this paper. The first model constructs the wireless sensor networks according to the connectivity and remaining energy of each sensor node, thus it can produce scale-free networks which have a performance of random error tolerance. In the second model, we not only consider the remaining energy, but also introduce the constraint of links to each node. This model can make the energy consumption of the whole network more balanced. Finally, we present the numerical experiments of the two models.

  16. Modeling online social networks based on preferential linking

    Institute of Scientific and Technical Information of China (English)

    Hu Hai-Bo; Guo Jin-Li; Chen Jun

    2012-01-01

    We study the phenomena of preferential linking in a large-scale evolving online social network and find that the linear preference holds for preferential creation,preferential acceptance,and preferential attachment.Based on the linear preference,we propose an analyzable model,which illustrates the mechanism of network growth and reproduces the process of network evolution.Our simulations demonstrate that the degree distribution of the network produced by the model is in good agreement with that of the real network.This work provides a possible bridge between the micro-mechanisms of network growth and the macrostructures of online social networks.

  17. Modeling online social networks based on preferential linking

    International Nuclear Information System (INIS)

    We study the phenomena of preferential linking in a large-scale evolving online social network and find that the linear preference holds for preferential creation, preferential acceptance, and preferential attachment. Based on the linear preference, we propose an analyzable model, which illustrates the mechanism of network growth and reproduces the process of network evolution. Our simulations demonstrate that the degree distribution of the network produced by the model is in good agreement with that of the real network. This work provides a possible bridge between the micro-mechanisms of network growth and the macrostructures of online social networks

  18. Network Modeling of Crohn's Disease Incidence.

    Directory of Open Access Journals (Sweden)

    Jean-Marc Victor

    Full Text Available Numerous genetic and environmental risk factors play a role in human complex genetic disorders (CGD. However, their complex interplay remains to be modelled and explained in terms of disease mechanisms.Crohn's Disease (CD was modeled as a modular network of patho-physiological functions, each summarizing multiple gene-gene and gene-environment interactions. The disease resulted from one or few specific combinations of module functional states. Network aging dynamics was able to reproduce age-specific CD incidence curves as well as their variations over the past century in Western countries. Within the model, we translated the odds ratios (OR associated to at-risk alleles in terms of disease propensities of the functional modules. Finally, the model was successfully applied to other CGD including ulcerative colitis, ankylosing spondylitis, multiple sclerosis and schizophrenia.Modeling disease incidence may help to understand disease causative chains, to delineate the potential of personalized medicine, and to monitor epidemiological changes in CGD.

  19. Decoupling MSW settlement into mechanical and biochemical processes--modelling and validation on large-scale setups.

    Science.gov (United States)

    Gourc, J-P; Staub, M J; Conte, M

    2010-01-01

    Forecasting settlements of non-hazardous waste is essential to ensure the integrity and durability of landfill covers over time. Over a short time span, the survey of settlements may also contribute to the investigation of the biodegradation processes. This paper addresses secondary settlements of Municipal Solid Waste (MSW), a heterogeneous and time-evolving material. An analysis of available experimental data from different pilots and the literature was conducted to quantify the influence of biodegradation on MSW secondary settlements. After making assumptions about the various features of the waste and their constitutive relationships, a one-dimensional biomechanical model to predict the secondary settlement has been developed. The determination of the total secondary settlement was obtained by the addition of two separate parts, the mechanical settlement, due to creep, and the biochemical settlement, due to the degradation of the organic matter. The latter has been evaluated based on the observed biogas production. Using the data from different recent large-scale experiments that provide a monitoring of biogas production, a method for predicting the biochemically-induced settlements is proposed and validated on these tests. The relative contributions of mechanical and biochemical settlements are also calculated and discussed as a function of waste pre-treatment and operation conditions (biological pre-treatment, shredding, leachate injection). Finally, settlement may be considered as a relevant indicator for the state of biodegradation. PMID:20381332

  20. EVALUATION OF THE EXTRACTS OF LEUCAS ASPERA ON BIOCHEMICAL PROFILES IN EXPERIMENTAL MODEL OF DIABETES MELLITUS (TYPE- I IN RATS

    Directory of Open Access Journals (Sweden)

    T.Tukaram

    2011-03-01

    Full Text Available The study was conducted to evaluate the effect of Leucas aspera leaves on experimental diabetes mellitus (type I in rats in terms of alterations in biochemical profiles. Thirty rats were randomly divided into six groups of 5 rats in each. Group-I were fed on basal diet without any treatment, group-II induced diabetic models (type-I (Alloxan monohydrate dissolved in sterile normal saline (150 mg/kgBW, ip, group-III, IV, V and VI were induced diabetics and treated with extract of Leucas aspera (30,100,150 and 300mg/kg BW respectively, PO twice daily in the morning and evening post prandially for thirty days respectively. The blood samples were collected on day 0, 10, 20 and 30 and were used for the analysis of biochemical profiles.The blood glucose (mg% were consistently increased significantly (P<0.01 in groups II,III, IV V and VI till day 20 while in groups V and VI there was a significant (P<0.01 decline in the values on day 30. There was found to have profound effect in lowering the blood glucose levels in dose dependent manner. The study revealed that experimental diabetes mellitus (type-I induced patho-biochemical changes were ameliorated more effectively by ethanolic extract of Leucas aspera in dose dependent manner.

  1. Modeling the Human Genome Maintenance network

    Science.gov (United States)

    Simão, Éder M.; Cabral, Heleno B.; Castro, Mauro A. A.; Sinigaglia, Marialva; Mombach, José C. M.; Librelotto, Giovani R.

    2010-10-01

    We present the Ontocancro Database ( www.ontocancro.org) illustrated with applications to network modeling and pathway functional analysis. The database compiles information on gene pathways involved in Human Genome Maintenance Mechanisms (GMM) whose dysfunction accounts for cancer and several genetic syndromes. Ontocancro is the most complete, manually curated information resource available providing genomics and interatomics data on 120 GMM pathways (comprising a total of 1435 genes) obtained from curated databases and the literature. It was developed to facilitate the GMM network and functional modeling for the integration of genomic, transcriptomic and interatomic data. The database’s main contribution is the Ontocancro pathways that are expanded versions of standard GMM pathways for including additional genes with evidences of functional involvement in GMM. Using these pathways we find the largest cluster of interacting proteins involving GMM and on it we project a microarray study of adenoma to identify the regions of the network that are highly altered. In the last application we present the dynamical alterations of the pathways in a study of the effect of Cadmium, a known carcinogenic substance, on prostate cells to find that it produces a strong decrease of the pathway activity.

  2. Stochastic ecological network occupancy (SENO) models: a new tool for modeling ecological networks across spatial scales

    Science.gov (United States)

    Lafferty, Kevin D.; Dunne, Jennifer A.

    2010-01-01

    Stochastic ecological network occupancy (SENO) models predict the probability that species will occur in a sample of an ecological network. In this review, we introduce SENO models as a means to fill a gap in the theoretical toolkit of ecologists. As input, SENO models use a topological interaction network and rates of colonization and extinction (including consumer effects) for each species. A SENO model then simulates the ecological network over time, resulting in a series of sub-networks that can be used to identify commonly encountered community modules. The proportion of time a species is present in a patch gives its expected probability of occurrence, whose sum across species gives expected species richness. To illustrate their utility, we provide simple examples of how SENO models can be used to investigate how topological complexity, species interactions, species traits, and spatial scale affect communities in space and time. They can categorize species as biodiversity facilitators, contributors, or inhibitors, making this approach promising for ecosystem-based management of invasive, threatened, or exploited species.

  3. Towards a Realistic Model for Failure Propagation in Interdependent Networks

    CERN Document Server

    Sturaro, Agostino; Conti, Mauro; Das, Sajal K

    2015-01-01

    Modern networks are becoming increasingly interdependent. As a prominent example, the smart grid is an electrical grid controlled through a communications network, which in turn is powered by the electrical grid. Such interdependencies create new vulnerabilities and make these networks more susceptible to failures. In particular, failures can easily spread across these networks due to their interdependencies, possibly causing cascade effects with a devastating impact on their functionalities. In this paper we focus on the interdependence between the power grid and the communications network, and propose a novel realistic model, HINT (Heterogeneous Interdependent NeTworks), to study the evolution of cascading failures. Our model takes into account the heterogeneity of such networks as well as their complex interdependencies. We compare HINT with previously proposed models both on synthetic and real network topologies. Experimental results show that existing models oversimplify the failure evolution and network...

  4. A hybrid neural network model for consciousness

    Institute of Scientific and Technical Information of China (English)

    蔺杰; 金小刚; 杨建刚

    2004-01-01

    A new framework for consciousness is introduced based upon traditional artificial neural network models. This framework reflects explicit connections between two parts of the brain: one global working memory and distributed modular cerebral networks relating to specific brain functions. Accordingly this framework is composed of three layers,physical mnemonic layer and abstract thinking layer,which cooperate together through a recognition layer to accomplish information storage and cognition using algorithms of how these interactions contribute to consciousness:(1)the reception process whereby cerebral subsystems group distributed signals into coherent object patterns;(2)the partial recognition process whereby patterns from particular subsystems are compared or stored as knowledge; and(3)the resonant learning process whereby global workspace stably adjusts its structure to adapt to patterns' changes. Using this framework,various sorts of human actions can be explained,leading to a general approach for analyzing brain functions.

  5. Modelling Traffic in IMS Network Nodes

    Directory of Open Access Journals (Sweden)

    BA Alassane

    2013-07-01

    Full Text Available IMS is well integrated with existing voice and data networks, while adopting many of their keycharacteristics.The Call Session Control Functions (CSCFs servers are the key part of the IMS structure. They are themain components responsible for processing and routing signalling messages.When CSCFs servers (P-CSCF, I-CSCF, S-CSCF are running on the same host, the SIP message can beinternally passed between SIP servers using a single operating system mechanism like a queue. It increasesthe reliability of the network [5], [6]. We have proposed in a last work for each type of service (between ICSCFand S-CSCF (call, data, multimedia.[23], to use less than two servers well dimensioned andrunning on the same operating system.Instead dimensioning servers, in order to increase performance, we try to model traffic on IMS nodes,particularly on entries nodes; it will provide results on separation of incoming flows, and then offer moresatisfactory service.

  6. A hybrid neural network model for consciousness

    Institute of Scientific and Technical Information of China (English)

    蔺杰; 金小刚; 杨建刚

    2004-01-01

    A new framework for consciousness is introduced based upon traditional artificial neural network models. This framework reflects explicit connections between two parts of the brain: one global working memory and distributed modular cerebral networks relating to specific brain functions. Accordingly this framework is composed of three layers, physical mnemonic layer and abstract thinking layer, which cooperate together through a recognition layer to accomplish information storage and cognition using algorithms of how these interactions contribute to consciousness: (l) the reception process whereby cerebral subsystems group distributed signals into coherent object patterns; (2) the partial recognition process whereby patterns from particular subsystems are compared or stored as knowledge; and (3) the resonant learning process whereby global workspace stably adjusts its structure to adapt to patterns' changes. Using this framework, various sorts of human actions can be explained, leading to a general approach for analyzing brain functions.

  7. Modeling GSM Based Network Communication in Vehicular Network

    OpenAIRE

    M. Milton Joe; Ramakrishnan, B.; R. S. Shaji

    2014-01-01

    Obviously fair communication establishment in every technology increases the efficiency. As we know well, vehicles are used in day to day life of every human being to move from one location to another location. If network communication is formed between vehicles, mobile phones and home based telephones, it will increase the safety of the passengers by communicating with one another. In this paper, we propose GSM based network communication in vehicles, which will develop reliable network comm...

  8. Optimizing neural network models: motivation and case studies

    OpenAIRE

    Harp, S A; T. Samad

    2012-01-01

    Practical successes have been achieved  with neural network models in a variety of domains, including energy-related industry. The large, complex design space presented by neural networks is only minimally explored in current practice. The satisfactory results that nevertheless have been obtained testify that neural networks are a robust modeling technology; at the same time, however, the lack of a systematic design approach implies that the best neural network models generally  rem...

  9. A Proposed "OSI Based" Network Troubles Identification Model

    Directory of Open Access Journals (Sweden)

    Murat Kayri

    2010-09-01

    Full Text Available The OSI model, developed by ISO in 1984, attempts to summarize complicated network cases on layers.Moreover, network troubles are expressed by taking the model into account. However, there has been nostandardization for network troubles up to now. Network troubles have only been expressed by the name ofthe related layer. In this paper, it is pointed out that possible troubles on the related layer vary and possibletroubles on each layer are categorized for functional network administration and they are standardized inan eligible way. The proposed model for network trouble shooting was developed considering the OSImodel

  10. Bayesian Recurrent Neural Network for Language Modeling.

    Science.gov (United States)

    Chien, Jen-Tzung; Ku, Yuan-Chu

    2016-02-01

    A language model (LM) is calculated as the probability of a word sequence that provides the solution to word prediction for a variety of information systems. A recurrent neural network (RNN) is powerful to learn the large-span dynamics of a word sequence in the continuous space. However, the training of the RNN-LM is an ill-posed problem because of too many parameters from a large dictionary size and a high-dimensional hidden layer. This paper presents a Bayesian approach to regularize the RNN-LM and apply it for continuous speech recognition. We aim to penalize the too complicated RNN-LM by compensating for the uncertainty of the estimated model parameters, which is represented by a Gaussian prior. The objective function in a Bayesian classification network is formed as the regularized cross-entropy error function. The regularized model is constructed not only by calculating the regularized parameters according to the maximum a posteriori criterion but also by estimating the Gaussian hyperparameter by maximizing the marginal likelihood. A rapid approximation to a Hessian matrix is developed to implement the Bayesian RNN-LM (BRNN-LM) by selecting a small set of salient outer-products. The proposed BRNN-LM achieves a sparser model than the RNN-LM. Experiments on different corpora show the robustness of system performance by applying the rapid BRNN-LM under different conditions.

  11. Epidemic model with isolation in multilayer networks

    CERN Document Server

    Zuzek, L G Alvarez; Braunstein, L A

    2014-01-01

    The Susceptible-Infected-Recovered (SIR) model has successfully mimicked the propagation of such airborne diseases as influenza A (H1N1). Although the SIR model has recently been studied in a multilayer networks configuration, in almost all the research the dynamic movement of infected individuals, e.g., how they are often kept in isolation, is disregarded. We study the SIR model in two multilayer networks and use an isolation parameter, indicating time period, to measure the effect of isolating infected individuals from both layers. This isolation reduces the transmission of the disease because the time in which infection can spread is reduced. In this scenario we find that the epidemic threshold increases with the isolation time and the isolation parameter and the impact of the propagation is reduced. We also find that when isolation is total there is a threshold for the isolation parameter above which the disease never becomes an epidemic. We also find that regular epidemic models always overestimate the e...

  12. Inferring gene regression networks with model trees

    Directory of Open Access Journals (Sweden)

    Aguilar-Ruiz Jesus S

    2010-10-01

    Full Text Available Abstract Background Novel strategies are required in order to handle the huge amount of data produced by microarray technologies. To infer gene regulatory networks, the first step is to find direct regulatory relationships between genes building the so-called gene co-expression networks. They are typically generated using correlation statistics as pairwise similarity measures. Correlation-based methods are very useful in order to determine whether two genes have a strong global similarity but do not detect local similarities. Results We propose model trees as a method to identify gene interaction networks. While correlation-based methods analyze each pair of genes, in our approach we generate a single regression tree for each gene from the remaining genes. Finally, a graph from all the relationships among output and input genes is built taking into account whether the pair of genes is statistically significant. For this reason we apply a statistical procedure to control the false discovery rate. The performance of our approach, named REGNET, is experimentally tested on two well-known data sets: Saccharomyces Cerevisiae and E.coli data set. First, the biological coherence of the results are tested. Second the E.coli transcriptional network (in the Regulon database is used as control to compare the results to that of a correlation-based method. This experiment shows that REGNET performs more accurately at detecting true gene associations than the Pearson and Spearman zeroth and first-order correlation-based methods. Conclusions REGNET generates gene association networks from gene expression data, and differs from correlation-based methods in that the relationship between one gene and others is calculated simultaneously. Model trees are very useful techniques to estimate the numerical values for the target genes by linear regression functions. They are very often more precise than linear regression models because they can add just different linear

  13. Design and Implementation of a Network Security Model for Cooperative Network

    Directory of Open Access Journals (Sweden)

    Salah Alabady

    2009-06-01

    Full Text Available In this paper a design and implementation of a network security model was presented, using routers and firewall.Also this paper was conducted the network security weakness in router and firewall network devices, type of threats andresponses to those threats, and the method to prevent the attacks and hackers to access the network. Also this paper provides achecklist to use in evaluating whether a network is adhering to best practices in network security and data confidentiality. Themain aim of this research is to protect the network from vulnerabilities, threats, attacks, configuration weaknesses and securitypolicy weaknesses.

  14. BioJazz: in silico evolution of cellular networks with unbounded complexity using rule-based modeling.

    Science.gov (United States)

    Feng, Song; Ollivier, Julien F; Swain, Peter S; Soyer, Orkun S

    2015-10-30

    Systems biologists aim to decipher the structure and dynamics of signaling and regulatory networks underpinning cellular responses; synthetic biologists can use this insight to alter existing networks or engineer de novo ones. Both tasks will benefit from an understanding of which structural and dynamic features of networks can emerge from evolutionary processes, through which intermediary steps these arise, and whether they embody general design principles. As natural evolution at the level of network dynamics is difficult to study, in silico evolution of network models can provide important insights. However, current tools used for in silico evolution of network dynamics are limited to ad hoc computer simulations and models. Here we introduce BioJazz, an extendable, user-friendly tool for simulating the evolution of dynamic biochemical networks. Unlike previous tools for in silico evolution, BioJazz allows for the evolution of cellular networks with unbounded complexity by combining rule-based modeling with an encoding of networks that is akin to a genome. We show that BioJazz can be used to implement biologically realistic selective pressures and allows exploration of the space of network architectures and dynamics that implement prescribed physiological functions. BioJazz is provided as an open-source tool to facilitate its further development and use. Source code and user manuals are available at: http://oss-lab.github.io/biojazz and http://osslab.lifesci.warwick.ac.uk/BioJazz.aspx.

  15. Social network models predict movement and connectivity in ecological landscapes

    Science.gov (United States)

    Fletcher, Robert J.; Acevedo, M.A.; Reichert, Brian E.; Pias, Kyle E.; Kitchens, Wiley M.

    2011-01-01

    Network analysis is on the rise across scientific disciplines because of its ability to reveal complex, and often emergent, patterns and dynamics. Nonetheless, a growing concern in network analysis is the use of limited data for constructing networks. This concern is strikingly relevant to ecology and conservation biology, where network analysis is used to infer connectivity across landscapes. In this context, movement among patches is the crucial parameter for interpreting connectivity but because of the difficulty of collecting reliable movement data, most network analysis proceeds with only indirect information on movement across landscapes rather than using observed movement to construct networks. Statistical models developed for social networks provide promising alternatives for landscape network construction because they can leverage limited movement information to predict linkages. Using two mark-recapture datasets on individual movement and connectivity across landscapes, we test whether commonly used network constructions for interpreting connectivity can predict actual linkages and network structure, and we contrast these approaches to social network models. We find that currently applied network constructions for assessing connectivity consistently, and substantially, overpredict actual connectivity, resulting in considerable overestimation of metapopulation lifetime. Furthermore, social network models provide accurate predictions of network structure, and can do so with remarkably limited data on movement. Social network models offer a flexible and powerful way for not only understanding the factors influencing connectivity but also for providing more reliable estimates of connectivity and metapopulation persistence in the face of limited data.

  16. Dynamic Pathloss Model for Future Mobile Communication Networks

    DEFF Research Database (Denmark)

    Kumar, Ambuj; Mihovska, Albena Dimitrova; Prasad, Ramjee

    2016-01-01

    — Future mobile communication networks (MCNs) are expected to be more intelligent and proactive based on new capabilities that increase agility and performance. However, for any successful mobile network service, the dexterity in network deployment is a key factor. The efficiency of the network p...... that incorporates the environmental dynamics factor in the propagation model for intelligent and proactively iterative networks...... that are essentially static. Therefore, once the signal level drops beyond the predicted values due to any variance in the environmental conditions, very crowded areas may not be catered well enough by the deployed network that had been designed with the static path loss model. This paper proposes an approach......— Future mobile communication networks (MCNs) are expected to be more intelligent and proactive based on new capabilities that increase agility and performance. However, for any successful mobile network service, the dexterity in network deployment is a key factor. The efficiency of the network...

  17. Communications network design and costing model users manual

    Science.gov (United States)

    Logan, K. P.; Somes, S. S.; Clark, C. A.

    1983-01-01

    The information and procedures needed to exercise the communications network design and costing model for performing network analysis are presented. Specific procedures are included for executing the model on the NASA Lewis Research Center IBM 3033 computer. The concepts, functions, and data bases relating to the model are described. Model parameters and their format specifications for running the model are detailed.

  18. Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia.

    Science.gov (United States)

    Drozdov, Ignat; Svejda, Bernhard; Gustafsson, Bjorn I; Mane, Shrikant; Pfragner, Roswitha; Kidd, Mark; Modlin, Irvin M

    2011-01-01

    Small intestinal (SI) neuroendocrine tumors (NET) are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments can objectively define signaling machinery in this disease. Genome-wide co-expression analysis was used to infer gene relevance network in SI-NETs. The network was confirmed to be non-random, scale-free, and highly modular. Functional analysis of gene co-expression modules revealed processes including 'Nervous system development', 'Immune response', and 'Cell-cycle'. Importantly, gene network topology and differential expression analysis identified over-expression of the GPCR signaling regulators, the cAMP synthetase, ADCY2, and the protein kinase A, PRKAR1A. Seven CREB response element (CRE) transcripts associated with proliferation and secretion: BEX1, BICD1, CHGB, CPE, GABRB3, SCG2 and SCG3 as well as ADCY2 and PRKAR1A were measured in an independent SI dataset (n = 10 NETs; n = 8 normal preparations). All were up-regulated (psystem, confirmed that transcriptional effects are signaled through the cAMP/PKA/pCREB signaling pathway and that a SI NET cell line was most sensitive to a D(2) and 5-HT(2) receptor agonist BIM-53061. PMID:21853033

  19. Neural Networks For Electrohydrodynamic Effect Modelling

    Directory of Open Access Journals (Sweden)

    Wiesław Wajs

    2004-01-01

    Full Text Available This paper presents currently achieved results concerning methods of electrohydrodynamiceffect used in geophysics simulated with feedforward networks trained with backpropagation algorithm, radial basis function networks and generalized regression networks.

  20. Neural Networks for Electrohydrodynamic Effect Modelling

    Directory of Open Access Journals (Sweden)

    Jolanta Gancarz

    2004-01-01

    Full Text Available This paper presents currently achieved results concerning methods of electrohydrodynamic effect used in geophysics simulated with feedforward networks trained with backpropagation algorithm, radial basis function networks and generalized regression networks.

  1. Modeling GSM Based Network Communication in Vehicular Network

    Directory of Open Access Journals (Sweden)

    M. Milton Joe

    2014-02-01

    Full Text Available Obviously fair communication establishment in every technology increases the efficiency. As we know well, vehicles are used in day to day life of every human being to move from one location to another location. If network communication is formed between vehicles, mobile phones and home based telephones, it will increase the safety of the passengers by communicating with one another. In this paper, we propose GSM based network communication in vehicles, which will develop reliable network communication between vehicles, mobile phones and home based telephones. The added advantage GSM based network communication among vehicles will lead to safety of travel by tracking the vehicle's location, since GSM based network communication is established in vehicles.

  2. Modeling and Robustness of Knowledge Network in Supply Chain

    Institute of Scientific and Technical Information of China (English)

    王道平; 沈睿芳

    2014-01-01

    The growth and evolution of the knowledge network in supply chain can be characterized by dynamic growth clustering and non-homogeneous degree distribution. The networks with the above characteristics are also known as scale-free networks. In this paper, the knowledge network model in supply chain is established, in which the preferential attachment mechanism based on the node strength is adopted to simulate the growth and evolution of the network. The nodes in the network have a certain preference in the choice of a knowledge partner. On the basis of the network model, the robustness of the three network models based on different preferential attachment strategies is in-vestigated. The robustness is also referred to as tolerances when the nodes are subjected to random destruction and malicious damage. The simulation results of this study show that the improved network has higher connectivity and stability.

  3. New generation of elastic network models.

    Science.gov (United States)

    López-Blanco, José Ramón; Chacón, Pablo

    2016-04-01

    The intrinsic flexibility of proteins and nucleic acids can be grasped from remarkably simple mechanical models of particles connected by springs. In recent decades, Elastic Network Models (ENMs) combined with Normal Model Analysis widely confirmed their ability to predict biologically relevant motions of biomolecules and soon became a popular methodology to reveal large-scale dynamics in multiple structural biology scenarios. The simplicity, robustness, low computational cost, and relatively high accuracy are the reasons behind the success of ENMs. This review focuses on recent advances in the development and application of ENMs, paying particular attention to combinations with experimental data. Successful application scenarios include large macromolecular machines, structural refinement, docking, and evolutionary conservation. PMID:26716577

  4. Fundamentals of complex networks models, structures and dynamics

    CERN Document Server

    Chen, Guanrong; Li, Xiang

    2014-01-01

    Complex networks such as the Internet, WWW, transportationnetworks, power grids, biological neural networks, and scientificcooperation networks of all kinds provide challenges for futuretechnological development. In particular, advanced societies havebecome dependent on large infrastructural networks to an extentbeyond our capability to plan (modeling) and to operate (control).The recent spate of collapses in power grids and ongoing virusattacks on the Internet illustrate the need for knowledge aboutmodeling, analysis of behaviors, optimized planning and performancecontrol in such networks. F

  5. Pruning Boltzmann networks and hidden Markov models

    DEFF Research Database (Denmark)

    Pedersen, Morten With; Stork, D.

    1996-01-01

    We present sensitivity-based pruning algorithms for general Boltzmann networks. Central to our methods is the efficient calculation of a second-order approximation to the true weight saliencies in a cross-entropy error. Building upon previous work which shows a formal correspondence between linea...... and thus the proper weight is pruned at each pruning step. In all our experiments in small problems, pruning reduces the generalization error; in most cases the pruned networks facilitate interpretation as well......We present sensitivity-based pruning algorithms for general Boltzmann networks. Central to our methods is the efficient calculation of a second-order approximation to the true weight saliencies in a cross-entropy error. Building upon previous work which shows a formal correspondence between linear...... Boltzmann chains and hidden Markov models (HMMs), we argue that our method can be applied to HMMs as well. We illustrate pruning on Boltzmann zippers, which are equivalent to two HMMs with cross-connection links. We verify that our second-order approximation preserves the rank ordering of weight saliencies...

  6. A Search Model with a Quasi-Network

    DEFF Research Database (Denmark)

    Ejarque, Joao Miguel

    This paper adds a quasi-network to a search model of the labor market. Fitting the model to an average unemployment rate and to other moments in the data implies the presence of the network is not noticeable in the basic properties of the unemployment and job finding rates. However, the network c...

  7. Improved simultaneous estimation of tracer kinetic models with artificial immune network based optimization method.

    Science.gov (United States)

    Liu, L; Ding, H; Huang, H B

    2016-01-01

    Tracer kinetic modeling (TKM) is a promising quantitative method for physiological and biochemical processes in vivo. In this paper, we investigated the applications of an immune-inspired method to better address the issues of Simultaneous Estimation (SIME) of TKM with multimodal optimization. Experiments of dynamic FDG PET imaging experiments and simulation studies were carried out. The proposed artificial immune network (TKM_AIN) shows more scalable and effective when compared with the gradient-based Marquardt-Levenberg algorithm and the scholastic-based simulated annealing method. PMID:26433131

  8. Compartmentalization analysis using discrete fracture network models

    Energy Technology Data Exchange (ETDEWEB)

    La Pointe, P.R.; Eiben, T.; Dershowitz, W. [Golder Associates, Redmond, VA (United States); Wadleigh, E. [Marathon Oil Co., Midland, TX (United States)

    1997-08-01

    This paper illustrates how Discrete Fracture Network (DFN) technology can serve as a basis for the calculation of reservoir engineering parameters for the development of fractured reservoirs. It describes the development of quantitative techniques for defining the geometry and volume of structurally controlled compartments. These techniques are based on a combination of stochastic geometry, computational geometry, and graph the theory. The parameters addressed are compartment size, matrix block size and tributary drainage volume. The concept of DFN models is explained and methodologies to compute these parameters are demonstrated.

  9. Networks model of the East Turkistan terrorism

    Science.gov (United States)

    Li, Ben-xian; Zhu, Jun-fang; Wang, Shun-guo

    2015-02-01

    The presence of the East Turkistan terrorist network in China can be traced back to the rebellions on the BAREN region in Xinjiang in April 1990. This article intends to research the East Turkistan networks in China and offer a panoramic view. The events, terrorists and their relationship are described using matrices. Then social network analysis is adopted to reveal the network type and the network structure characteristics. We also find the crucial terrorist leader. Ultimately, some results show that the East Turkistan network has big hub nodes and small shortest path, and that the network follows a pattern of small world network with hierarchical structure.

  10. A model of chlorpyrifos distribution and its biochemical effects on the liver and kidneys of rats.

    Science.gov (United States)

    Tanvir, E M; Afroz, R; Chowdhury, Maz; Gan, S H; Karim, N; Islam, M N; Khalil, M I

    2016-09-01

    This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test group; n = 6 each). The test group received CPF via oral gavage for 21 days at 5 mg/kg daily. The distribution of CPF was determined in various organs (liver, brain, heart, lung, kidney, ovary, adipose tissue, and skeletal muscle), urine and stool samples using GCMS. Approximately 6.18% of CPF was distributed in the body tissues, and the highest CPF concentration (3.80%) was found in adipose tissue. CPF also accumulated in the liver (0.29%), brain (0.22%), kidney (0.10%), and ovary (0.03%). Approximately 83.60% of CPF was detected in the urine. CPF exposure resulted in a significant increase in plasma transaminases, alkaline phosphatase, and total bilirubin levels, a significant reduction in total protein levels and an altered lipid profile. Oxidative stress due to CPF administration was also evidenced by a significant increase in liver malondialdehyde levels. The detrimental effects of CPF on kidney function consisted of a significant increase in plasma urea and creatinine levels. Liver and kidney histology confirmed the observed biochemical changes. In conclusion, CPF bioaccumulates over time and exerts toxic effects on animals. PMID:26519480

  11. A model of chlorpyrifos distribution and its biochemical effects on the liver and kidneys of rats.

    Science.gov (United States)

    Tanvir, E M; Afroz, R; Chowdhury, Maz; Gan, S H; Karim, N; Islam, M N; Khalil, M I

    2016-09-01

    This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test group; n = 6 each). The test group received CPF via oral gavage for 21 days at 5 mg/kg daily. The distribution of CPF was determined in various organs (liver, brain, heart, lung, kidney, ovary, adipose tissue, and skeletal muscle), urine and stool samples using GCMS. Approximately 6.18% of CPF was distributed in the body tissues, and the highest CPF concentration (3.80%) was found in adipose tissue. CPF also accumulated in the liver (0.29%), brain (0.22%), kidney (0.10%), and ovary (0.03%). Approximately 83.60% of CPF was detected in the urine. CPF exposure resulted in a significant increase in plasma transaminases, alkaline phosphatase, and total bilirubin levels, a significant reduction in total protein levels and an altered lipid profile. Oxidative stress due to CPF administration was also evidenced by a significant increase in liver malondialdehyde levels. The detrimental effects of CPF on kidney function consisted of a significant increase in plasma urea and creatinine levels. Liver and kidney histology confirmed the observed biochemical changes. In conclusion, CPF bioaccumulates over time and exerts toxic effects on animals.

  12. Artificial neural network models for image understanding

    Science.gov (United States)

    Kulkarni, Arun D.; Byars, P.

    1991-06-01

    In this paper we introduce a new class of artificial neural network (ANN) models based on transformed domain feature extraction. Many optical and/or digital recognition systems based on transformed domain feature extraction are available in practice. Optical systems are inherently parallel in nature and are preferred for real time applications, whereas digital systems are more suitable for nonlinear operations. In our ANN models we combine advantages of both digital and optical systems. Many transformed domain feature extraction techniques have been developed during the last three decades. They include: the Fourier transform (FT), the Walsh Hadamard transform (WHT), the discrete cosine transform (DCT), etc. As an example, we have developed ANN models using the FT and WHT domain features. The models consist of two stages, the feature extraction stage and the recognition stage. We have used back-propagation and competitive learning algorithms in the recognition stage. We have used these ANN models for invariant object recognition. The models have been used successfully to recognize various types of aircraft, and also have been tested with test patterns. ANN models based on other transforms can be developed in a similar fashion.

  13. Traffic chaotic dynamics modeling and analysis of deterministic network

    Science.gov (United States)

    Wu, Weiqiang; Huang, Ning; Wu, Zhitao

    2016-07-01

    Network traffic is an important and direct acting factor of network reliability and performance. To understand the behaviors of network traffic, chaotic dynamics models were proposed and helped to analyze nondeterministic network a lot. The previous research thought that the chaotic dynamics behavior was caused by random factors, and the deterministic networks would not exhibit chaotic dynamics behavior because of lacking of random factors. In this paper, we first adopted chaos theory to analyze traffic data collected from a typical deterministic network testbed — avionics full duplex switched Ethernet (AFDX, a typical deterministic network) testbed, and found that the chaotic dynamics behavior also existed in deterministic network. Then in order to explore the chaos generating mechanism, we applied the mean field theory to construct the traffic dynamics equation (TDE) for deterministic network traffic modeling without any network random factors. Through studying the derived TDE, we proposed that chaotic dynamics was one of the nature properties of network traffic, and it also could be looked as the action effect of TDE control parameters. A network simulation was performed and the results verified that the network congestion resulted in the chaotic dynamics for a deterministic network, which was identical with expectation of TDE. Our research will be helpful to analyze the traffic complicated dynamics behavior for deterministic network and contribute to network reliability designing and analysis.

  14. A Model of Genetic Variation in Human Social Networks

    CERN Document Server

    Fowler, James H; Christakis, Nicholas A

    2008-01-01

    Social networks influence the evolution of cooperation and they exhibit strikingly systematic patterns across a wide range of human contexts. Both of these facts suggest that variation in the topological attributes of human social networks might have a genetic basis. While genetic variation accounts for a significant portion of the variation in many complex social behaviors, the heritability of egocentric social network attributes is unknown. Here we show that three of these attributes (in-degree, transitivity, and centrality) are heritable. We then develop a "mirror network" method to test extant network models and show that none accounts for observed genetic variation in human social networks. We propose an alternative "attract and introduce" model that generates significant heritability as well as other important network features, and we show that this model with two simple forms of heterogeneity is well suited to the modeling of real social networks in humans. These results suggest that natural selection ...

  15. A Time Series Modeling and Prediction of Wireless Network Traffic

    Directory of Open Access Journals (Sweden)

    S. Gowrishankar

    2009-01-01

    Full Text Available The number of users and their network utilization will enumerate the traffic of the network. The accurate and timely estimation of network traffic is increasingly becoming important in achieving guaranteed Quality of Service (QoS in a wireless network. The better QoS can be maintained in the network by admission control, inter or intra network handovers by knowing the network traffic in advance. Here wireless network traffic is modeled as a nonlinear and nonstationary time series. In this framework, network traffic is predicted using neural network and statistical methods. The results of both the methods are compared on different time scales or time granularity. The Neural Network(NN architectures used in this study are Recurrent Radial Basis Function Network (RRBFN and Echo state network (ESN.The statistical model used here in this work is Fractional Auto Regressive Integrated Moving Average (FARIMA model. The traffic prediction accuracy of neural network and statistical models are in the range of 96.4% to 98.3% and 78.5% to 80.2% respectively.

  16. A hybrid routing model for mitigating congestion in networks

    Science.gov (United States)

    He, Kun; Xu, Zhongzhi; Wang, Pu

    2015-08-01

    Imbalance between fast-growing transport demand and limited network supply has resulted in severe congestion in many transport networks. Increasing network supply or reducing transport demand could mitigate congestion, but these remedies are usually associated with high implementation cost. Combining shortest path (SP) routing and minimum cost (MC) routing, we developed a hybrid routing model to alleviate congestion in networks. This model requires only a small fraction of the total number of agents to use MC routes, and effectively mitigates congestion in networks under homogeneous or heterogeneous transport demand, offering new insights for improving the efficiency of practical transport networks.

  17. A novel mathematical model for coverage in wireless sensor network

    Institute of Scientific and Technical Information of China (English)

    YAN Zhen-ya; ZHENG Bao-yu

    2006-01-01

    Coverage problem is one of the fundamental issues in the design of wireless sensor network, which has a great impact on the performance of sensor network. In this article,coverage problem was investigated using a mathematical model named Birth-death process. In this model, sensor nodes joining into networks at every period of time is considered as the rebirth of network and the quitting of sensor nodes from the networks is considered as the death of the network. In the end, an analytical solution is used to investigate the appropriate rate to meet the coverage requirement.

  18. Echo state networks as an alternative to traditional artificial neural networks in rainfall–runoff modelling

    Directory of Open Access Journals (Sweden)

    N. J. de Vos

    2013-01-01

    Full Text Available Despite theoretical benefits of recurrent artificial neural networks over their feedforward counterparts, it is still unclear whether the former offer practical advantages as rainfall–runoff models. The main drawback of recurrent networks is the increased complexity of the training procedure due to their architecture. This work uses the recently introduced and conceptually simple echo state networks for streamflow forecasts on twelve river basins in the Eastern United States, and compares them to a variety of traditional feedforward and recurrent approaches. Two modifications on the echo state network models are made that increase the hydrologically relevant information content of their internal state. The results show that the echo state networks outperform feedforward networks and are competitive with state-of-the-art recurrent networks, across a range of performance measures. This, along with their simplicity and ease of training, suggests that they can be considered promising alternatives to traditional artificial neural networks in rainfall–runoff modelling.

  19. Echo state networks as an alternative to traditional artificial neural networks in rainfall-runoff modelling

    Science.gov (United States)

    de Vos, N. J.

    2013-01-01

    Despite theoretical benefits of recurrent artificial neural networks over their feedforward counterparts, it is still unclear whether the former offer practical advantages as rainfall-runoff models. The main drawback of recurrent networks is the increased complexity of the training procedure due to their architecture. This work uses the recently introduced and conceptually simple echo state networks for streamflow forecasts on twelve river basins in the Eastern United States, and compares them to a variety of traditional feedforward and recurrent approaches. Two modifications on the echo state network models are made that increase the hydrologically relevant information content of their internal state. The results show that the echo state networks outperform feedforward networks and are competitive with state-of-the-art recurrent networks, across a range of performance measures. This, along with their simplicity and ease of training, suggests that they can be considered promising alternatives to traditional artificial neural networks in rainfall-runoff modelling.

  20. An Improved Car-Following Model in Vehicle Networking Based on Network Control

    Directory of Open Access Journals (Sweden)

    D. Y. Kong

    2014-01-01

    Full Text Available Vehicle networking is a system to realize information interoperability between vehicles and people, vehicles and roads, vehicles and vehicles, and cars and transport facilities, through the network information exchange, in order to achieve the effective monitoring of the vehicle and traffic flow. Realizing information interoperability between vehicles and vehicles, which can affect the traffic flow, is an important application of network control system (NCS. In this paper, a car-following model using vehicle networking theory is established, based on network control principle. The car-following model, which is an improvement of the traditional traffic model, describes the traffic in vehicle networking condition. The impact that vehicle networking has on the traffic flow is quantitatively assessed in a particular scene of one-way, no lane changing highway. The examples show that the capacity of the road is effectively enhanced by using vehicle networking.

  1. Performance of an integrated network model

    Science.gov (United States)

    Lehmann, François; Dunn, David; Beaulieu, Marie-Dominique; Brophy, James

    2016-01-01

    Objective To evaluate the changes in accessibility, patients’ care experiences, and quality-of-care indicators following a clinic’s transformation into a fully integrated network clinic. Design Mixed-methods study. Setting Verdun, Que. Participants Data on all patient visits were used, in addition to 2 distinct patient cohorts: 134 patients with chronic illness (ie, diabetes, arteriosclerotic heart disease, or both); and 450 women between the ages of 20 and 70 years. Main outcome measures Accessibility was measured by the number of walk-in visits, scheduled visits, and new patient enrolments. With the first cohort, patients’ care experiences were measured using validated serial questionnaires; and quality-of-care indicators were measured using biologic data. With the second cohort, quality of preventive care was measured using the number of Papanicolaou tests performed as a surrogate marker. Results Despite a negligible increase in the number of physicians, there was an increase in accessibility after the clinic’s transition to an integrated network model. During the first 4 years of operation, the number of scheduled visits more than doubled, nonscheduled visits (walk-in visits) increased by 29%, and enrolment of vulnerable patients (those with chronic illnesses) at the clinic remained high. Patient satisfaction with doctors was rated very highly at all points of time that were evaluated. While the number of Pap tests done did not increase with time, the proportion of patients meeting hemoglobin A1c and low-density lipoprotein guideline target levels increased, as did the number of patients tested for microalbuminuria. Conclusion Transformation to an integrated network model of care led to increased efficiency and enhanced accessibility with no negative effects on the doctor-patient relationship. Improvements in biologic data also suggested better quality of care. PMID:27521410

  2. An Adaptive Complex Network Model for Brain Functional Networks

    OpenAIRE

    Gomez Portillo, Ignacio J.; Gleiser, Pablo M.

    2009-01-01

    Brain functional networks are graph representations of activity in the brain, where the vertices represent anatomical regions and the edges their functional connectivity. These networks present a robust small world topological structure, characterized by highly integrated modules connected sparsely by long range links. Recent studies showed that other topological properties such as the degree distribution and the presence (or absence) of a hierarchical structure are not robust, and show diffe...

  3. A graph model for opportunistic network coding

    KAUST Repository

    Sorour, Sameh

    2015-08-12

    © 2015 IEEE. Recent advancements in graph-based analysis and solutions of instantly decodable network coding (IDNC) trigger the interest to extend them to more complicated opportunistic network coding (ONC) scenarios, with limited increase in complexity. In this paper, we design a simple IDNC-like graph model for a specific subclass of ONC, by introducing a more generalized definition of its vertices and the notion of vertex aggregation in order to represent the storage of non-instantly-decodable packets in ONC. Based on this representation, we determine the set of pairwise vertex adjacency conditions that can populate this graph with edges so as to guarantee decodability or aggregation for the vertices of each clique in this graph. We then develop the algorithmic procedures that can be applied on the designed graph model to optimize any performance metric for this ONC subclass. A case study on reducing the completion time shows that the proposed framework improves on the performance of IDNC and gets very close to the optimal performance.

  4. Determining Application Runtimes Using Queueing Network Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Michael L. [Univ. of San Francisco, CA (United States)

    2006-12-14

    Determination of application times-to-solution for large-scale clustered computers continues to be a difficult problem in high-end computing, which will only become more challenging as multi-core consumer machines become more prevalent in the market. Both researchers and consumers of these multi-core systems desire reasonable estimates of how long their programs will take to run (time-to-solution, or TTS), and how many resources will be consumed in the execution. Currently there are few methods of determining these values, and those that do exist are either overly simplistic in their assumptions or require great amounts of effort to parameterize and understand. One previously untried method is queuing network modeling (QNM), which is easy to parameterize and solve, and produces results that typically fall within 10 to 30% of the actual TTS for our test cases. Using characteristics of the computer network (bandwidth, latency) and communication patterns (number of messages, message length, time spent in communication), the QNM model of the NAS-PB CG application was applied to MCR and ALC, supercomputers at LLNL, and the Keck Cluster at USF, with average errors of 2.41%, 3.61%, and -10.73%, respectively, compared to the actual TTS observed. While additional work is necessary to improve the predictive capabilities of QNM, current results show that QNM has a great deal of promise for determining application TTS for multi-processor computer systems.

  5. Marketing communications model for innovation networks

    Directory of Open Access Journals (Sweden)

    Tiago João Freitas Correia

    2015-10-01

    Full Text Available Innovation is an increasingly relevant concept for the success of any organization, but it also represents a set of internal and external considerations, barriers and challenges to overcome. Along the concept of innovation, new paradigms emerge such as open innovation and co-creation that are simultaneously innovation modifiers and intensifiers in organizations, promoting organizational openness and stakeholder integration within the value creation process. Innovation networks composed by a multiplicity of agents in co-creative work perform as innovation mechanisms to face the increasingly complexity of products, services and markets. Technology, especially the Internet, is an enabler of all process among organizations supported by co-creative platforms for innovation. The definition of marketing communication strategies that promote motivation and involvement of all stakeholders in synergic creation and external promotion is the central aspect of this research. The implementation of the projects is performed by participative workshops with stakeholders from Madan Parque through IDEAS(REVOLUTION methodology and the operational model LinkUp parameterized for the project. The project is divided into the first part, the theoretical framework, and the second part where a model is developed for the marketing communication strategies that appeal to the Madan Parque case study. Keywords: Marketing Communication; Open Innovation, Technology; Innovation Networks; Incubator; Co-Creation.

  6. Modeling management of research and education networks

    NARCIS (Netherlands)

    Galagan, D.V.

    2004-01-01

    Computer networks and their services have become an essential part of research and education. Nowadays every modern R&E institution must have a computer network and provide network services to its students and staff. In addition to its internal computer network, every R&E institution must have a con

  7. Random Network Models and Quantum Phase Transitions in Two Dimensions

    OpenAIRE

    Kramer, B.; Ohtsuki, T.; Kettemann, S.

    2004-01-01

    An overview of the random network model invented by Chalker and Coddington, and its generalizations, is provided. After a short introduction into the physics of the Integer Quantum Hall Effect, which historically has been the motivation for introducing the network model, the percolation model for electrons in spatial dimension 2 in a strong perpendicular magnetic field and a spatially correlated random potential is described. Based on this, the network model is established, using the concepts...

  8. Neural Networks in Economic Modelling: An Empirical Study.

    OpenAIRE

    Verkooijen, W.J.H.

    1996-01-01

    Abstract: This dissertation addresses the statistical aspects of neural networks and their usability for solving problems in economics and finance. Neural networks are discussed in a framework of modelling which is generally accepted in econometrics. Within this framework a neural network is regarded as a statistical technique that implements a model-free regression strategy. Model-free regression seems particularly useful in situations where economic theory cannot provide sensible model spec...

  9. Importance of realistic mobility models for vanet network simulation

    OpenAIRE

    Boukenadil, Bahidja

    2014-01-01

    In the performance evaluation of a protocol for a vehicular ad hoc network, the protocol should be tested under a realistic conditions including, representative data traffic models, and realistic movements of the mobile nodes which are the vehicles (i.e., a mobility model). This work is a comparative study between two mobility models that are used in the simulations of vehicular networks, i.e., MOVE (MObility model generator for VEhicular networks) and CityMob, a mobility pattern generator fo...

  10. Multilevel method for modeling large-scale networks.

    Energy Technology Data Exchange (ETDEWEB)

    Safro, I. M. (Mathematics and Computer Science)

    2012-02-24

    Understanding the behavior of real complex networks is of great theoretical and practical significance. It includes developing accurate artificial models whose topological properties are similar to the real networks, generating the artificial networks at different scales under special conditions, investigating a network dynamics, reconstructing missing data, predicting network response, detecting anomalies and other tasks. Network generation, reconstruction, and prediction of its future topology are central issues of this field. In this project, we address the questions related to the understanding of the network modeling, investigating its structure and properties, and generating artificial networks. Most of the modern network generation methods are based either on various random graph models (reinforced by a set of properties such as power law distribution of node degrees, graph diameter, and number of triangles) or on the principle of replicating an existing model with elements of randomization such as R-MAT generator and Kronecker product modeling. Hierarchical models operate at different levels of network hierarchy but with the same finest elements of the network. However, in many cases the methods that include randomization and replication elements on the finest relationships between network nodes and modeling that addresses the problem of preserving a set of simplified properties do not fit accurately enough the real networks. Among the unsatisfactory features are numerically inadequate results, non-stability of algorithms on real (artificial) data, that have been tested on artificial (real) data, and incorrect behavior at different scales. One reason is that randomization and replication of existing structures can create conflicts between fine and coarse scales of the real network geometry. Moreover, the randomization and satisfying of some attribute at the same time can abolish those topological attributes that have been undefined or hidden from

  11. Topological evolution of virtual social networks by modeling social activities

    Science.gov (United States)

    Sun, Xin; Dong, Junyu; Tang, Ruichun; Xu, Mantao; Qi, Lin; Cai, Yang

    2015-09-01

    With the development of Internet and wireless communication, virtual social networks are becoming increasingly important in the formation of nowadays' social communities. Topological evolution model is foundational and critical for social network related researches. Up to present most of the related research experiments are carried out on artificial networks, however, a study of incorporating the actual social activities into the network topology model is ignored. This paper first formalizes two mathematical abstract concepts of hobbies search and friend recommendation to model the social actions people exhibit. Then a social activities based topology evolution simulation model is developed to satisfy some well-known properties that have been discovered in real-world social networks. Empirical results show that the proposed topology evolution model has embraced several key network topological properties of concern, which can be envisioned as signatures of real social networks.

  12. Infinite multiple membership relational modeling for complex networks

    DEFF Research Database (Denmark)

    Mørup, Morten; Schmidt, Mikkel Nørgaard; Hansen, Lars Kai

    2011-01-01

    Learning latent structure in complex networks has become an important problem fueled by many types of networked data originating from practically all fields of science. In this paper, we propose a new non-parametric Bayesian multiple-membership latent feature model for networks. Contrary to exist......Learning latent structure in complex networks has become an important problem fueled by many types of networked data originating from practically all fields of science. In this paper, we propose a new non-parametric Bayesian multiple-membership latent feature model for networks. Contrary...... to existing multiplemembership models that scale quadratically in the number of vertices the proposed model scales linearly in the number of links admitting multiple-membership analysis in large scale networks. We demonstrate a connection between the single membership relational model and multiple membership...

  13. Free energetics of rigid body association of ubiquitin binding domains: a biochemical model for binding mediated by hydrophobic interaction.

    Science.gov (United States)

    Cui, Di; Ou, Shuching; Patel, Sandeep

    2014-07-01

    Weak intermolecular interactions, such as hydrophobic associations, underlie numerous biomolecular recognition processes. Ubiquitin is a small protein that represents a biochemical model for exploring thermodynamic signatures of hydrophobic association as it is widely held that a major component of ubiquitin's binding to numerous partners is mediated by hydrophobic regions on both partners. Here, we use atomistic molecular dynamics simulations in conjunction with the Adaptive Biasing Force sampling method to compute potentials of mean force (the reversible work, or free energy, associated with the binding process) to investigate the thermodynamic signature of complexation in this well-studied biochemical model of hydrophobic association. We observe that much like in the case of a purely hydrophobic solute (i.e., graphene, carbon nanotubes), association is favored by entropic contributions from release of water from the interprotein regions. Moreover, association is disfavored by loss of enthalpic interactions, but unlike in the case of purely hydrophobic solutes, in this case protein-water interactions are lost and not compensated for by additional water-water interactions generated upon release of interprotein and moreso, hydration, water. We further find that relative orientations of the proteins that mutually present hydrophobic regions of each protein to its partner are favored over those that do not. In fact, the free energy minimum as predicted by a force field based method recapitulates the experimental NMR solution structure of the complex.

  14. A fusion networking model for smart grid power distribution backbone communication network based on PTN

    Directory of Open Access Journals (Sweden)

    Wang Hao

    2016-01-01

    Full Text Available In current communication network for distribution in Chinese power grid systems, the fiber communication backbone network for distribution and TD-LTE power private wireless backhaul network of power grid are both bearing by the SDH optical transmission network, which also carries the communication network of transformer substation and main electric. As the data traffic of the distribution communication and TD-LTE power private wireless network grow rapidly in recent years, it will have a big impact with the SDH network’s bearing capacity which is mainly used for main electric communication in high security level. This paper presents a fusion networking model which use a multiple-layer PTN network as the unified bearing of the TD-LTE power private wireless backhaul network and fiber communication backbone network for distribution. Network dataflow analysis shows that this model can greatly reduce the capacity pressure of the traditional SDH network as well as ensure the reliability of the transmission of the communication network for distribution and TD-LTE power private wireless network.

  15. Road network safety evaluation using Bayesian hierarchical joint model.

    Science.gov (United States)

    Wang, Jie; Huang, Helai

    2016-05-01

    Safety and efficiency are commonly regarded as two significant performance indicators of transportation systems. In practice, road network planning has focused on road capacity and transport efficiency whereas the safety level of a road network has received little attention in the planning stage. This study develops a Bayesian hierarchical joint model for road network safety evaluation to help planners take traffic safety into account when planning a road network. The proposed model establishes relationships between road network risk and micro-level variables related to road entities and traffic volume, as well as socioeconomic, trip generation and network density variables at macro level which are generally used for long term transportation plans. In addition, network spatial correlation between intersections and their connected road segments is also considered in the model. A road network is elaborately selected in order to compare the proposed hierarchical joint model with a previous joint model and a negative binomial model. According to the results of the model comparison, the hierarchical joint model outperforms the joint model and negative binomial model in terms of the goodness-of-fit and predictive performance, which indicates the reasonableness of considering the hierarchical data structure in crash prediction and analysis. Moreover, both random effects at the TAZ level and the spatial correlation between intersections and their adjacent segments are found to be significant, supporting the employment of the hierarchical joint model as an alternative in road-network-level safety modeling as well.

  16. Models as Tools of Analysis of a Network Organisation

    Directory of Open Access Journals (Sweden)

    Wojciech Pająk

    2013-06-01

    Full Text Available The paper presents models which may be applied as tools of analysis of a network organisation. The starting point of the discussion is defining the following terms: supply chain and network organisation. Further parts of the paper present basic assumptions analysis of a network organisation. Then the study characterises the best known models utilised in analysis of a network organisation. The purpose of the article is to define the notion and the essence of network organizations and to present the models used for their analysis.

  17. Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Chinmaya; López, José Manuel; Azencott, Robert; Ott, William [Department of Mathematics, University of Houston, Houston, Texas 77004 (United States); Bennett, Matthew R. [Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77204, USA and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77005 (United States); Josić, Krešimir [Department of Mathematics, University of Houston, Houston, Texas 77004 (United States); Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 (United States)

    2014-05-28

    Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein. Genetic regulatory networks are therefore frequently modeled as stochastic birth-death processes with delay. Here, we examine the relationship between delay birth-death processes and their appropriate approximating delay chemical Langevin equations. We prove a quantitative bound on the error between the pathwise realizations of these two processes. Our results hold for both fixed delay and distributed delay. Simulations demonstrate that the delay chemical Langevin approximation is accurate even at moderate system sizes. It captures dynamical features such as the oscillatory behavior in negative feedback circuits, cross-correlations between nodes in a network, and spatial and temporal information in two commonly studied motifs of metastability in biochemical systems. Overall, these results provide a foundation for using delay stochastic differential equations to approximate the dynamics of birth-death processes with delay.

  18. Resolving structural variability in network models and the brain.

    Directory of Open Access Journals (Sweden)

    Florian Klimm

    2014-03-01

    Full Text Available Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little is known in general about mechanistic drivers of structured networks. Here we contrast network properties derived from diffusion spectrum imaging data of the human brain with 13 synthetic network models chosen to probe the roles of physical network embedding and temporal network growth. We characterize both the empirical and synthetic networks using familiar graph metrics, but presented here in a more complete statistical form, as scatter plots and distributions, to reveal the full range of variability of each measure across scales in the network. We focus specifically on the degree distribution, degree assortativity, hierarchy, topological Rentian scaling, and topological fractal scaling--in addition to several summary statistics, including the mean clustering coefficient, the shortest path-length, and the network diameter. The models are investigated in a progressive, branching sequence, aimed at capturing different elements thought to be important in the brain, and range from simple random and regular networks, to models that incorporate specific growth rules and constraints. We find that synthetic models that constrain the network nodes to be physically embedded in anatomical brain regions tend to produce distributions that are most similar to the corresponding measurements for the brain. We also find that network models hardcoded to display one network property (e.g., assortativity do not in general simultaneously display a second (e.g., hierarchy. This relative independence of network properties suggests that multiple neurobiological mechanisms might be at play in the development of human brain network architecture. Together, the network models that we develop and employ provide a potentially useful

  19. A last updating evolution model for online social networks

    Science.gov (United States)

    Bu, Zhan; Xia, Zhengyou; Wang, Jiandong; Zhang, Chengcui

    2013-05-01

    As information technology has advanced, people are turning to electronic media more frequently for communication, and social relationships are increasingly found on online channels. However, there is very limited knowledge about the actual evolution of the online social networks. In this paper, we propose and study a novel evolution network model with the new concept of “last updating time”, which exists in many real-life online social networks. The last updating evolution network model can maintain the robustness of scale-free networks and can improve the network reliance against intentional attacks. What is more, we also found that it has the “small-world effect”, which is the inherent property of most social networks. Simulation experiment based on this model show that the results and the real-life data are consistent, which means that our model is valid.

  20. Multi-agent Based Modeling of Manufacturing Network

    Institute of Scientific and Technical Information of China (English)

    GUO Yuming; SUN Yanming; ZHENG Shixiong

    2006-01-01

    An intelligent manufacturing system is modeled currently from the viewpoint of manufacturing applications, and the network platform's influence to manufacturing applications is not considered adequately. However any bottleneck in service oriented architecture (SOA) for the manufacturing network can affect the agility of the IT environment. In this paper, to achieve a trade-off between manufacturing resources and network resources, the manufacturing network is modeled with multi-agent, in which two kinds of basic elements, the manufacturing application unit and the network carrier of manufacturing information, are presented. And their main characters are described by colored petri net. The manufacturing application model drives the network platform that inversely provides this application model technology supports. The proposed multi-agent system is demonstrated through an example integration scenario involving production plan, resources management and execution subsystems. And the result suggests that analyzing and designing the system architecture of networked manufacturing should give due attention to the operation system as well as manufacturing applications.

  1. Natural Models for Evolution on Networks

    CERN Document Server

    Mertzios, George B; Raptopoulos, Christoforos; Spirakis, Paul G

    2011-01-01

    Evolutionary dynamics have been traditionally studied in the context of homogeneous populations, mainly described my the Moran process. Recently, this approach has been generalized in \\cite{LHN} by arranging individuals on the nodes of a network. Undirected networks seem to have a smoother behavior than directed ones, and thus it is more challenging to find suppressors/amplifiers of selection. In this paper we present the first class of undirected graphs which act as suppressors of selection, by achieving a fixation probability that is at most one half of that of the complete graph, as the number of vertices increases. Moreover, we provide some generic upper and lower bounds for the fixation probability of general undirected graphs. As our main contribution, we introduce the natural alternative of the model proposed in \\cite{LHN}, where all individuals interact simultaneously and the result is a compromise between aggressive and non-aggressive individuals. That is, the behavior of the individuals in our new m...

  2. Supplier Selection in Virtual Enterprise Model of Manufacturing Supply Network

    Science.gov (United States)

    Kaihara, Toshiya; Opadiji, Jayeola F.

    The market-based approach to manufacturing supply network planning focuses on the competitive attitudes of various enterprises in the network to generate plans that seek to maximize the throughput of the network. It is this competitive behaviour of the member units that we explore in proposing a solution model for a supplier selection problem in convergent manufacturing supply networks. We present a formulation of autonomous units of the network as trading agents in a virtual enterprise network interacting to deliver value to market consumers and discuss the effect of internal and external trading parameters on the selection of suppliers by enterprise units.

  3. Research on Remote Network Bidirectional Detect and Control Model

    Directory of Open Access Journals (Sweden)

    Hongyao Ju

    2013-09-01

    Full Text Available Remote network bidirectional detect and control technologies are the key factors to solve local network allopatry expansibility and management. With studying gateway integration technology, bidirectional VPN technology, identity authentication technology and dynamic host management technology can be integrated into gateway. Thus, bidirectional connect and control among allopatry local networks based on Internet can be solved. Whole area expansibility of local network is realized. With experiment, the model is proved to finish remote bidirectional interconnection of local network automatically and to obtain allopatry local users authority. The equipment detecting and controlling in remote local networks are realized.  

  4. Modeling community structure and topics in dynamic text networks

    CERN Document Server

    Henry, Teague; Chai, Christine; Owens-Oas, Derek

    2016-01-01

    The last decade has seen great progress in both dynamic network modeling and topic modeling. This paper draws upon both areas to create a Bayesian method that allows topic discovery to inform the latent network model and the network structure to facilitate topic identification. We apply this method to the 467 top political blogs of 2012. Our results find complex community structure within this set of blogs, where community membership depends strongly upon the set of topics in which the blogger is interested.

  5. Agent Based Modeling on Organizational Dynamics of Terrorist Network

    OpenAIRE

    Bo Li; Duoyong Sun; Renqi Zhu; Ze Li

    2015-01-01

    Modeling organizational dynamics of terrorist network is a critical issue in computational analysis of terrorism research. The first step for effective counterterrorism and strategic intervention is to investigate how the terrorists operate with the relational network and what affects the performance. In this paper, we investigate the organizational dynamics by employing a computational experimentation methodology. The hierarchical cellular network model and the organizational dynamics model ...

  6. A dynamic epidemic control model on uncorrelated complex networks

    Institute of Scientific and Technical Information of China (English)

    Pei Wei-Dong; Chen Zeng-Qiang; Yuan Zhu-Zhi

    2008-01-01

    In this paper,a dynamic epidemic control model on the uncorrelated complex networks is proposed.By means of theoretical analysis,we found that the new model has a similar epidemic threshold as that of the susceptible-infectedrecovered (SIR) model on the above networks,but it can reduce the prevalence of the infected individuals remarkably.This result may help us understand epidemic spreading phenomena on real networks and design appropriate strategies to control infections.

  7. Model for the growth of the World Airline Network

    CERN Document Server

    Verma, T; Nagler, J; Andrade, J S; Herrmann, H J

    2016-01-01

    We propose a probabilistic growth model for transport networks which employs a balance between popularity of nodes and the physical distance between nodes. By comparing the degree of each node in the model network and the WAN, we observe that the difference between the two is minimized for $\\alpha\\approx 2$. Interestingly, this is the value obtained for the node-node correlation function in the WAN. This suggests that our model explains quite well the growth of airline networks.

  8. Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study

    Directory of Open Access Journals (Sweden)

    Wadén Johan

    2009-10-01

    Full Text Available Background Cardiovascular disease is the main cause of premature death in patients with type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack or stroke. Accurate knowledge of the complex inter-dependencies between the risk factors is critical for pinpointing the best targets for research and treatment. Therefore, the aim of this study was to describe the association patterns between clinical and biochemical features of diabetic complications. Methods Medical records and serum and urine samples of 4,197 patients with type 1 diabetes were collected from health care centers in Finland. At baseline, the mean diabetes duration was 22 years, 52% were male, 23% had kidney disease (urine albumin excretion over 300 mg/24 h or end-stage renal disease and 8% had a history of macrovascular events. All-cause mortality was evaluated after an average of 6.5 years of follow-up (25,714 patient years. The dataset comprised 28 clinical and 25 biochemical variables that were regarded as the nodes of a network to assess their mutual relationships. Results The networks contained cliques that were densely inter-connected (r > 0.6, including cliques for high-density lipoprotein (HDL markers, for triglycerides and cholesterol, for urinary excretion and for indices of body mass. The links between the cliques showed biologically relevant interactions: an inverse relationship between HDL cholesterol and the triglyceride clique (r P -16, a connection between triglycerides and body mass via C-reactive protein (r > 0.3, P -16 and intermediate-density cholesterol as the connector between lipoprotein metabolism and albuminuria (r > 0.3, P -16. Aging and macrovascular disease were linked to death via working ability and retinopathy. Diabetic kidney disease, serum creatinine and potassium, retinopathy and blood pressure were inter-connected. Blood pressure correlations indicated accelerated vascular aging in individuals with kidney disease

  9. Modeling of polymer networks for application to solid propellant formulating

    Science.gov (United States)

    Marsh, H. E.

    1979-01-01

    Methods for predicting the network structural characteristics formed by the curing of pourable elastomers were presented; as well as the logic which was applied in the development of mathematical models. A universal approach for modeling was developed and verified by comparison with other methods in application to a complex system. Several applications of network models to practical problems are described.

  10. Structural equation models from paths to networks

    CERN Document Server

    Westland, J Christopher

    2015-01-01

    This compact reference surveys the full range of available structural equation modeling (SEM) methodologies.  It reviews applications in a broad range of disciplines, particularly in the social sciences where many key concepts are not directly observable.  This is the first book to present SEM’s development in its proper historical context–essential to understanding the application, strengths and weaknesses of each particular method.  This book also surveys the emerging path and network approaches that complement and enhance SEM, and that will grow in importance in the near future.  SEM’s ability to accommodate unobservable theory constructs through latent variables is of significant importance to social scientists.  Latent variable theory and application are comprehensively explained, and methods are presented for extending their power, including guidelines for data preparation, sample size calculation, and the special treatment of Likert scale data.  Tables of software, methodologies and fit st...

  11. Adaptive Networks Theory, Models and Applications

    CERN Document Server

    Gross, Thilo

    2009-01-01

    With adaptive, complex networks, the evolution of the network topology and the dynamical processes on the network are equally important and often fundamentally entangled. Recent research has shown that such networks can exhibit a plethora of new phenomena which are ultimately required to describe many real-world networks. Some of those phenomena include robust self-organization towards dynamical criticality, formation of complex global topologies based on simple, local rules, and the spontaneous division of "labor" in which an initially homogenous population of network nodes self-organizes into functionally distinct classes. These are just a few. This book is a state-of-the-art survey of those unique networks. In it, leading researchers set out to define the future scope and direction of some of the most advanced developments in the vast field of complex network science and its applications.

  12. An Improved Walk Model for Train Movement on Railway Network

    International Nuclear Information System (INIS)

    In this paper, we propose an improved walk model for simulating the train movement on railway network. In the proposed method, walkers represent trains. The improved walk model is a kind of the network-based simulation analysis model. Using some management rules for walker movement, walker can dynamically determine its departure and arrival times at stations. In order to test the proposed method, we simulate the train movement on a part of railway network. The numerical simulation and analytical results demonstrate that the improved model is an effective tool for simulating the train movement on railway network. Moreover, it can well capture the characteristic behaviors of train scheduling in railway traffic. (general)

  13. An Improved Walk Model for Train Movement on Railway Network

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; MAO Bo-Hua; GAO Zi-You

    2009-01-01

    In this paper, we propose an improved walk model for simulating the train movement on railway network. In the proposed method, walkers represent trains. The improved walk model is a kind of the network-based simulation analysis model. Using some management rules for walker movement, walker can dynamically determine its departure and arrival times at stations. In order to test the proposed method, we simulate the train movement on a part of railway network. The numerical simulation and analytical results demonstrate that the improved model is an effective tool for simulating the train movement on railway network. Moreover, it can well capture the characteristic behaviors of train scheduling in railway traffic.

  14. Infinite Multiple Membership Relational Modeling for Complex Networks

    DEFF Research Database (Denmark)

    Mørup, Morten; Schmidt, Mikkel Nørgaard; Hansen, Lars Kai

    Learning latent structure in complex networks has become an important problem fueled by many types of networked data originating from practically all fields of science. In this paper, we propose a new non-parametric Bayesian multiplemembership latent feature model for networks. Contrary to existing...... multiplemembership models that scale quadratically in the number of vertices the proposedmodel scales linearly in the number of links admittingmultiple-membership analysis in large scale networks. We demonstrate a connection between the single membership relational model and multiple membership models and show...

  15. Image-Based Structural Modeling of the Cardiac Purkinje Network

    Directory of Open Access Journals (Sweden)

    Benjamin R. Liu

    2015-01-01

    Full Text Available The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the genesis and maintenance of ventricular arrhythmias. Despite its importance, few structural models of the Purkinje network have been developed, primarily because current physical limitations prevent examination of the intact Purkinje network. In previous modeling efforts Purkinje-like structures have been developed through either automated or hand-drawn procedures, but these networks have been created according to general principles rather than based on real networks. To allow for greater realism in Purkinje structural models, we present a method for creating three-dimensional Purkinje networks based directly on imaging data. Our approach uses Purkinje network structures extracted from photographs of dissected ventricles and projects these flat networks onto realistic endocardial surfaces. Using this method, we create models for the combined ventricle-Purkinje system that can fully activate the ventricles through a stimulus delivered to the Purkinje network and can produce simulated activation sequences that match experimental observations. The combined models have the potential to help elucidate Purkinje network contributions during ventricular arrhythmias.

  16. A new local-world evolving network model

    Institute of Scientific and Technical Information of China (English)

    Qin Sen; Dai Guan-Zhong

    2009-01-01

    In some real complex networks, only a few nodes can obtain the global information about the entire networks, but most of the nodes own only local connections therefore own only local information of the networks. A new local-world evolving network model is proposed in this paper. In the model, not all the nodes obtain local network information, which is different from the local world network model proposed by Li and Chen (LC model). In the LC model, each node has only the local connections therefore owns only local information about the entire networks. Theoretical analysis and numerical simulation show that adjusting the ratio of the number of nodes obtaining the global information of the network to the total number of nodes can effectively control the valuing range for the power-law exponent of the new network. Therefore, if the topological structure of a complex network, especially its exponent of power-law degree distribution, needs controlling, we just add or take away a few nodes which own the global information of the network.

  17. Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.

    Directory of Open Access Journals (Sweden)

    Anna Kubesova

    Full Text Available Perinatal immune challenge leads to neurodevelopmental dysfunction, permanent immune dysregulation and abnormal behaviour, which have been shown to have translational validity to findings in human neuropsychiatric disorders (e.g. schizophrenia, mood and anxiety disorders, autism, Parkinson's disease and Alzheimer's disease. The aim of this animal study was to elucidate the influence of early immune stimulation triggered by systemic postnatal lipopolysaccharide administration on biochemical, histopathological and morphological measures, which may be relevant to the neurobiology of human psychopathology. In the present study of adult male Wistar rats we examined the brain and plasma levels of monoamines (dopamine, serotonin, their metabolites, the levels of the main excitatory and inhibitory neurotransmitters glutamate and γ-aminobutyric acid and the levels of tryptophan and its metabolites from the kynurenine catabolic pathway. Further, we focused on histopathological and morphological markers related to pathogenesis of brain diseases--glial cell activation, neurodegeneration, hippocampal volume reduction and dopaminergic synthesis in the substantia nigra. Our results show that early immune stimulation in adult animals alters the levels of neurotransmitters and their metabolites, activates the kynurenine pathway of tryptophan metabolism and leads to astrogliosis, hippocampal volume reduction and a decrease of tyrosine hydroxylase immunoreactivity in the substantia nigra. These findings support the crucial pathophysiological role of early immune stimulation in the above mentioned neuropsychiatric disorders.

  18. A Gaussian Mixed Model for Learning Discrete Bayesian Networks.

    Science.gov (United States)

    Balov, Nikolay

    2011-02-01

    In this paper we address the problem of learning discrete Bayesian networks from noisy data. Considered is a graphical model based on mixture of Gaussian distributions with categorical mixing structure coming from a discrete Bayesian network. The network learning is formulated as a Maximum Likelihood estimation problem and performed by employing an EM algorithm. The proposed approach is relevant to a variety of statistical problems for which Bayesian network models are suitable - from simple regression analysis to learning gene/protein regulatory networks from microarray data.

  19. Performance Modeling for Heterogeneous Wireless Networks with Multiservice Overflow Traffic

    DEFF Research Database (Denmark)

    Huang, Qian; Ko, King-Tim; Iversen, Villy Bæk

    2009-01-01

    Performance modeling is important for the purpose of developing efficient dimensioning tools for large complicated networks. But it is difficult to achieve in heterogeneous wireless networks, where different networks have different statistical characteristics in service and traffic models....... Multiservice loss analysis based on multi-dimensional Markov chain becomes intractable in these networks due to intensive computations required. This paper focuses on performance modeling for heterogeneous wireless networks based on a hierarchical overlay infrastructure. A method based on decomposition...... of the correlated traffic is used to achieve an approximate performance modeling for multiservice in hierarchical heterogeneous wireless networks with overflow traffic. The accuracy of the approximate performance obtained by our proposed modeling is verified by simulations....

  20. Turing instability in reaction-diffusion models on complex networks

    Science.gov (United States)

    Ide, Yusuke; Izuhara, Hirofumi; Machida, Takuya

    2016-09-01

    In this paper, the Turing instability in reaction-diffusion models defined on complex networks is studied. Here, we focus on three types of models which generate complex networks, i.e. the Erdős-Rényi, the Watts-Strogatz, and the threshold network models. From analysis of the Laplacian matrices of graphs generated by these models, we numerically reveal that stable and unstable regions of a homogeneous steady state on the parameter space of two diffusion coefficients completely differ, depending on the network architecture. In addition, we theoretically discuss the stable and unstable regions in the cases of regular enhanced ring lattices which include regular circles, and networks generated by the threshold network model when the number of vertices is large enough.

  1. Extended master equation models for molecular communication networks

    CERN Document Server

    Chou, Chun Tung

    2012-01-01

    We consider molecular communication networks consisting of transmitters and receivers distributed in a fluidic medium. In such networks, a transmitter sends one or more signalling molecules, which are diffused over the medium, to the receiver to realise the communication. In order to be able to engineer synthetic molecular communication networks, mathematical models for these networks are required. This paper proposes a new stochastic model for molecular communication networks called reaction-diffusion master equation with exogenous input (RDMEX). The key idea behind RDMEX is to model the transmitters as time sequences specify the emission patterns of signalling molecules, while diffusion in the medium and chemical reactions at the receivers are modelled as Markov processes using master equation. An advantage of RDMEX is that it can readily be used to model molecular communication networks with multiple transmitters and receivers. For the case where the reaction kinetics at the receivers is linear, we show ho...

  2. Network structure, topology, and dynamics in generalized models of synchronization

    Science.gov (United States)

    Lerman, Kristina; Ghosh, Rumi

    2012-08-01

    Network structure is a product of both its topology and interactions between its nodes. We explore this claim using the paradigm of distributed synchronization in a network of coupled oscillators. As the network evolves to a global steady state, nodes synchronize in stages, revealing the network's underlying community structure. Traditional models of synchronization assume that interactions between nodes are mediated by a conservative process similar to diffusion. However, social and biological processes are often nonconservative. We propose a model of synchronization in a network of oscillators coupled via nonconservative processes. We study the dynamics of synchronization of a synthetic and real-world networks and show that the traditional and nonconservative models of synchronization reveal different structures within the same network.

  3. Model of Controlling the Hubs in P2P Networks

    Directory of Open Access Journals (Sweden)

    Yuhua Liu

    2009-06-01

    Full Text Available Research into the hubs in Peer-to-Peer (P2P networks, and present a new method to avoid generating the hubs in the networks by controlling the logical topology structure of P2P networks. We firstly introduce the controlling ideas about hierarchizing the hubs. Then, we disclose and interpret the controlling model, and give out the concrete method to carry it out. Finally, we validate our controlling model via simulations and the simulation results demonstrate that our work is effective to control the hubs in P2P networks. Thus, this model can improve the network competence to defend against coordinated attacks, promote the network robustness, and ensure the network would develop continually and healthily.

  4. A dual modelling of evolving political opinion networks

    CERN Document Server

    Wang, Ru

    2012-01-01

    We present the result of a dual modeling of opinion network. The model complements the agent-based opinion models by attaching to the social agent (voters) network a political opinion (party) network having its own intrinsic mechanisms of evolution. These two sub-networks form a global network which can be either isolated from or dependent on the external influence. Basically, the evolution of the agent network includes link adding and deleting, the opinion changes influenced by social validation, the political climate, the attractivity of the parties and the interaction between them. The opinion network is initially composed of numerous nodes representing opinions or parties which are located on a one dimensional axis according to their political positions. The mechanism of evolution includes union, splitting, change of position and of attractivity, taken into account the pairwise node interaction decaying with node distance in power law. The global evolution ends in a stable distribution of the social agent...

  5. Identification of efflux proteins using efficient radial basis function networks with position-specific scoring matrices and biochemical properties.

    Science.gov (United States)

    Ou, Yu-Yen; Chen, Shu-An; Chang, Yun-Min; Velmurugan, Devadasan; Fukui, Kazuhiko; Michael Gromiha, M

    2013-09-01

    Efflux proteins are membrane proteins, which are involved in the transportation of multidrugs. The annotation of efflux proteins in genomic sequences would aid to understand the function. Although the percentage of membrane proteins in genomes is estimated to be 25-30%, there is no information about the content of efflux proteins. For annotating such class of proteins it is necessary to develop a reliable method to identify efflux proteins from amino acid sequence information. In this work, we have developed a method based on radial basis function networks using position specific scoring matrices (PSSM) and amino acid properties. We noticed that the C-terminal domain of efflux proteins contain vital information for discrimination. Our method showed an accuracy of 78 and 92% in discriminating efflux proteins from transporters and membrane proteins, respectively using fivefold cross-validation. We utilized our method for annotating the genomes E. coli and P. aeruginosa and it predicted 8.7 and 9.2% of proteins as efflux proteins in these genomes, respectively. The predicted efflux proteins have been compared with available experimental data and we observed a very good agreement between them. Further, we developed a web server for classifying efflux proteins and it is freely available at http://rbf.bioinfo.tw/∼sachen/EFFLUXpredict/Efflux-RBF.php. We suggest that our method could be an effective tool for annotating efflux proteins in genomic sequences.

  6. Classification of transporters using efficient radial basis function networks with position-specific scoring matrices and biochemical properties.

    Science.gov (United States)

    Ou, Yu-Yen; Chen, Shu-An; Gromiha, M Michael

    2010-05-15

    Transporters are proteins that are involved in the movement of ions or molecules across biological membranes. Transporters are generally classified into channels/pores, electrochemical transporters, and active transporters. Discriminating the specific class of transporters and their subfamilies are essential tasks in computational biology for the advancement of structural and functional genomics. We have systematically analyzed the amino acid composition, residue pair preference and amino acid properties in six different families of transporters. Utilizing the information, we have developed a radial basis function (RBF) network method based on profiles obtained with position specific scoring matrices for discriminating transporters belonging to three different classes and six families. Our method showed a fivefold cross validation accuracy of 76%, 73%, and 69% for discriminating transporters and nontransporters, three different classes and six different families of transporters, respectively. Further, the method was tested with independent datasets, which showed similar level of accuracy. A web server has been developed for discriminating transporters based on three classes and six families, and it is available at http://rbf.bioinfo.tw/ approximately sachen/tcrbf.html. We suggest that our method could be effectively used to identify transporters and discriminating them into different classes and families.

  7. Numerical modeling of gas mixing and bio-chemical transformations during underground hydrogen storage within the project H2STORE

    Science.gov (United States)

    Hagemann, B.; Feldmann, F.; Panfilov, M.; Ganzer, L.

    2015-12-01

    The change from fossil to renewable energy sources is demanding an increasing amount of storage capacities for electrical energy. A promising technological solution is the storage of hydrogen in the subsurface. Hydrogen can be produced by electrolysis using excessive electrical energy and subsequently converted back into electricity by fuel cells or engine generators. The development of this technology starts with adding small amounts of hydrogen to the high pressure natural gas grid and continues with the creation of pure underground hydrogen storages. The feasibility of hydrogen storage in depleted gas reservoirs is investigated in the lighthouse project H2STORE financed by the German Ministry for Education and Research. The joint research project has project members from the University of Jena, the Clausthal University of Technology, the GFZ Potsdam and the French National Center for Scientic Research in Nancy. The six sub projects are based on laboratory experiments, numerical simulations and analytical work which cover the investigation of mineralogical, geochemical, physio-chemical, sedimentological, microbiological and gas mixing processes in reservoir and cap rocks. The focus in this presentation is on the numerical modeling of underground hydrogen storage. A mathematical model was developed which describes the involved coupled hydrodynamic and microbiological effects. Thereby, the bio-chemical reaction rates depend on the kinetics of microbial growth which is induced by the injection of hydrogen. The model has been numerically implemented on the basis of the open source code DuMuX. A field case study based on a real German gas reservoir was performed to investigate the mixing of hydrogen with residual gases and to discover the consequences of bio-chemical reactions.

  8. Network games theory, models, and dynamics

    CERN Document Server

    Ozdaglar, Asu

    2011-01-01

    Traditional network optimization focuses on a single control objective in a network populated by obedient users and limited dispersion of information. However, most of today's networks are large-scale with lack of access to centralized information, consist of users with diverse requirements, and are subject to dynamic changes. These factors naturally motivate a new distributed control paradigm, where the network infrastructure is kept simple and the network control functions are delegated to individual agents which make their decisions independently (""selfishly""). The interaction of multiple

  9. Hybrid Modeling and Simulation of Automotive Supply Chain Network

    Directory of Open Access Journals (Sweden)

    Wen Wang

    2013-07-01

    Full Text Available According to the operation of automotive supply chain and the features of various simulation methods, we create and simulate a automotive supply chain network model with the core enterprise of two vehicle manufacturers, consisting of several parts suppliers, vehicle distributors and logistics service providers. On this basis of a conceptual model including the establishment of enterprise layer, business layer and operation layer, we establish a detailed model of the network system according to the network structure of automotive supply chain, the operation process and the internal business process of core enterprises; then we use System Dynamics (SD, Discrete Event Simulation (DES and Agent Based Modeling (ABM to describe the operating state of each node in the network model. We execute and analyze the simulation model of the whole network system described by Anylogic, using the results of the distributors’ inventory, inventory cost and customer’s satisfaction to prove the effectiveness of the model.

  10. Mixed-Membership Stochastic Block-Models for Transactional Networks

    CERN Document Server

    Shafiei, Mahdi

    2010-01-01

    Transactional network data can be thought of as a list of one-to-many communications(e.g., email) between nodes in a social network. Most social network models convert this type of data into binary relations between pairs of nodes. We develop a latent mixed membership model capable of modeling richer forms of transactional network data, including relations between more than two nodes. The model can cluster nodes and predict transactions. The block-model nature of the model implies that groups can be characterized in very general ways. This flexible notion of group structure enables discovery of rich structure in transactional networks. Estimation and inference are accomplished via a variational EM algorithm. Simulations indicate that the learning algorithm can recover the correct generative model. Interesting structure is discovered in the Enron email dataset and another dataset extracted from the Reddit website. Analysis of the Reddit data is facilitated by a novel performance measure for comparing two soft ...

  11. Northern emporia and maritime networks. Modelling past communication using archaeological network analysis

    DEFF Research Database (Denmark)

    Sindbæk, Søren Michael

    2015-01-01

    Long-distance communication has emerged as a particular focus for archaeologicalexploration using network theory, analysis, and modelling. The promise is apparentlyobvious: communication in the past doubtlessly had properties of complex, dynamicnetworks, and archaeological datasets almost certainly...... this is not a problem of network analysis, but network synthesis: theclassic problem of cracking codes or reconstructing black-box circuits. It is proposedthat archaeological approaches to network synthesis must involve a contextualreading of network data: observations arising from individual contexts, morphologies...... preserve patterns of thisinteraction. Formal network analysis and modelling holds the potential to identify anddemonstrate such patterns, where traditional methods often prove inadequate. Thearchaeological study of communication networks in the past, however, calls for radically different analytical...

  12. Modeling MAC layer for powerline communications networks

    Science.gov (United States)

    Hrasnica, Halid; Haidine, Abdelfatteh

    2001-02-01

    The usage of electrical power distribution networks for voice and data transmission, called Powerline Communications, becomes nowadays more and more attractive, particularly in the telecommunication access area. The most important reasons for that are the deregulation of the telecommunication market and a fact that the access networks are still property of former monopolistic companies. In this work, first we analyze a PLC network and system structure as well as a disturbance scenario in powerline networks. After that, we define a logical structure of the powerline MAC layer and propose the reservation MAC protocols for the usage in the PLC network which provides collision free data transmission. This makes possible better network utilization and realization of QoS guarantees which can make PLC networks competitive to other access technologies.

  13. A Survey on the Common Network Traffic Sources Models

    Directory of Open Access Journals (Sweden)

    Ahmed M. Mohammed

    2011-05-01

    Full Text Available Selecting the appropriate traffic model can lead to successful design of computer networks. Themore accurate the traffic model is the better the system quantified in terms of its performance.Successful design leads to enhancement the overall performance of the whole of network. Inliterature, there is innumerous traffic models proposed for understanding and analyzing the trafficcharacteristics of computer networks. Consequently, the study of traffic models to understand thefeatures of the models and identify eventually the best traffic model, for a concerned environmenthas become a crucial and lucrative task. Good traffic modeling is also a basic requirement foraccurate capacity planning. This paper provides an overview of some of the widely used networktraffic models, highlighting the core features of these models and traffic characteristics. Finally wefound that the N_BURST traffic model can capture the traffic characteristics of most types ofcomputer networks.

  14. Assessment of hemato-biochemical parameters on exposure to low level of deltamethrin in mouse model

    Directory of Open Access Journals (Sweden)

    Anita Tewari

    2014-03-01

    Full Text Available Aim: In this study, sub-acute toxicity of deltamethrin on hematological and biochemical blood parameters of male albino Swiss mice was evaluated. Materials and Methods: Generally, the maximum permissible residue level (MRL of deltamethrin for food products lies between 0.01 to 0.5 mg/kg body weight. So the mice were exposed orally with two doses of pesticide i.e. 0.1 and 0.5 mg/kg body weight. The doses were given on a daily basis for a period of 15 days and 30 days respectively. Ground nut oil was used as control treatment. Samples of blood were collected at the end of the treatment. Hepatotoxicity was evaluated by quantitative analysis of the serum enzymes alanine transaminase (ALT, aspartate transaminase (AST, alkaline phosphatase (ALKP, total bilirubin (TBIL and serum urea. Alterations of hematological parameters were analysed by total leukocyte, differential leukocyte count and hemoglobin levels. Results: Significant increase in the levels of hepatic enzymes (ALT, AST, ALKP were observed for both doses, but no considerable differences were found by histological analysis. The hematological parameters showed significant alterations for 0.5 mg/kg body weight dose which is indicated by leukocytosis, lymphocytosis and neutropenia in long duration study. Conclusions: The results indicated that even very low dose of deltamethrin can promote hematological and hepatic alterations. Thus it is imperative to do further studies on the detrimental effect of the low levels of pyrethroid commonly present in our food, which further necessitate the reduction of maximum permissible levels of residual synthetic pyrethroid levels in foods and feed.

  15. Communications network design and costing model technical manual

    Science.gov (United States)

    Logan, K. P.; Somes, S. S.; Clark, C. A.

    1983-01-01

    This computer model provides the capability for analyzing long-haul trunking networks comprising a set of user-defined cities, traffic conditions, and tariff rates. Networks may consist of all terrestrial connectivity, all satellite connectivity, or a combination of terrestrial and satellite connectivity. Network solutions provide the least-cost routes between all cities, the least-cost network routing configuration, and terrestrial and satellite service cost totals. The CNDC model allows analyses involving three specific FCC-approved tariffs, which are uniquely structured and representative of most existing service connectivity and pricing philosophies. User-defined tariffs that can be variations of these three tariffs are accepted as input to the model and allow considerable flexibility in network problem specification. The resulting model extends the domain of network analysis from traditional fixed link cost (distance-sensitive) problems to more complex problems involving combinations of distance and traffic-sensitive tariffs.

  16. Modeling of Magneto-Rheological Damper with Neural Network

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    With the revival of magnetorheological technology research in the 1980's, its application in vehicles is increasingly focused on vibration suppression. Based on the importance of magnetorheological damper modeling, nonparametric modeling with neural network, which is a promising development in semi-active online control of vehicles with MR suspension, has been carried out in this study. A two layer neural network with 7 neurons in a hidden layer and 3 inputs and 1 output was established to simulate the behavior of MR damper at different excitation currents. In the neural network modeling, the damping force is a function of displacement, velocity and the applied current. A MR damper for vehicles is fabricated and tested by MTS; the data acquired are utilized for neural network training and validation. The application and validation show that the predicted forces of the neural network match well with the forces tested with a small variance, which demonstrates the effectiveness and precision of neural network modeling.

  17. Network Modeling and Energy-Efficiency Optimization for Advanced Machine-to-Machine Sensor Networks

    Directory of Open Access Journals (Sweden)

    Seoksoo Kim

    2012-11-01

    Full Text Available Wireless machine-to-machine sensor networks with multiple radio interfaces are expected to have several advantages, including high spatial scalability, low event detection latency, and low energy consumption. Here, we propose a network model design method involving network approximation and an optimized multi-tiered clustering algorithm that maximizes node lifespan by minimizing energy consumption in a non-uniformly distributed network. Simulation results show that the cluster scales and network parameters determined with the proposed method facilitate a more efficient performance compared to existing methods.

  18. EURASIAN MINERAL WATER: MATHEMATICAL MODELING, CLASSIFICATION AND ASSESSMENT OF THEIR IMPACT ON THE BIOCHEMICAL COMPOSITION OF HUMAN BLOOD

    Directory of Open Access Journals (Sweden)

    Nikolay Kornilov

    2014-06-01

    Full Text Available In the article the results of comparative analysis of the composition of the Eurasian hydromineral resources and the assessment of their impact on the physiological condition of a human organism according to biochemical studies of venous blood are presented. Processing of initial data on the composition and properties of mineral waters chloride-hydrocarbonate, sulphate- hydrocarbonate and chloride-sulphate types and venous blood are made using the method of mathematical modeling, developed by the authors of this article. It is shown that in the balneological impact of hydromineral resources on the body in the blood increases the hemoglobin and oxygen, decreases glucose, and acid-base pH shifted to high alkalinity.

  19. Network models of frugivory and seed dispersal: Challenges and opportunities

    Science.gov (United States)

    Carlo, Tomás A.; Yang, Suann

    2011-11-01

    Network analyses have emerged as a new tool to study frugivory and seed dispersal (FSD) mutualisms because networks can model and simplify the complexity of multiple community-wide species interactions. Moreover, network theory suggests that structural properties, such as the presence of highly generalist species, are linked to the stability of mutualistic communities. However, we still lack empirical validation of network model predictions. Here we outline new research avenues to connect network models to FSD processes, and illustrate the challenges and opportunities of this tool with a field study. We hypothesized that generalist frugivores would be important for forest stability by dispersing seeds into deforested areas and initiating reforestation. We then constructed a network of plant-frugivore interactions using published data and identified the most generalist frugivores. To test the importance of generalists we measured: 1) the frequency with which frugivores moved between pasture and forest, 2) the bird-generated seed rain under perches in the pasture, and 3) the perching frequency of birds above seed traps. The generalist frugivores in the forest network were not important for seed dispersal into pastures, and thus for forest recovery, because the forest network excluded habitat heterogeneities, frugivore behavior, and movements. More research is needed to develop ways to incorporate relevant FSD processes into network models in order for these models to be more useful to community ecology and conservation. The network framework can serve to spark and renew interest in FSD and further our understanding of plant-animal communities.

  20. Hybrid neural network bushing model for vehicle dynamics simulation

    International Nuclear Information System (INIS)

    Although the linear model was widely used for the bushing model in vehicle suspension systems, it could not express the nonlinear characteristics of bushing in terms of the amplitude and the frequency. An artificial neural network model was suggested to consider the hysteretic responses of bushings. This model, however, often diverges due to the uncertainties of the neural network under the unexpected excitation inputs. In this paper, a hybrid neural network bushing model combining linear and neural network is suggested. A linear model was employed to represent linear stiffness and damping effects, and the artificial neural network algorithm was adopted to take into account the hysteretic responses. A rubber test was performed to capture bushing characteristics, where sine excitation with different frequencies and amplitudes is applied. Random test results were used to update the weighting factors of the neural network model. It is proven that the proposed model has more robust characteristics than a simple neural network model under step excitation input. A full car simulation was carried out to verify the proposed bushing models. It was shown that the hybrid model results are almost identical to the linear model under several maneuvers

  1. A unified constructive network model for problem-solving.

    Science.gov (United States)

    Takahashi, Y

    1996-01-01

    We develop a neural network model that relieves time-consuming trial-and-error computer experiments usually performed in problem-solving with networks where problems, including the traveling salesman problem, pattern matching and pattern classification/learning, are formulated as optimization problems with constraint. First, we specify and uniquely distinguish the model as a set of constituent functions that should comply with restrictive conditions. Next, we demonstrate that it is unified, i.e., it yields most current networks. Finally, we verify that it is constructive, that is, we show a standard method that systematically constructs from a given optimization problem a particular network in that model to solve it.

  2. Analytical Modeling of Uplink Cellular Networks

    CERN Document Server

    Novlan, Thomas D; Andrews, Jeffrey G

    2012-01-01

    Cellular uplink analysis has typically been undertaken by either a simple approach that lumps all interference into a single deterministic or random parameter in a Wyner-type model, or via complex system level simulations that often do not provide insight into why various trends are observed. This paper proposes a novel middle way that is both accurate and also results in easy-to-evaluate integral expressions based on the Laplace transform of the interference. We assume mobiles and base stations are randomly placed in the network with each mobile pairing up to its closest base station. The model requires two important changes compared to related recent work on the downlink. First, dependence is introduced between the user and base station point processes to make sure each base station serves a single mobile in the given resource block. Second, per-mobile power control is included, which further couples the locations of the mobiles and their receiving base stations. Nevertheless, we succeed in deriving the cov...

  3. Small is beautiful: models of small neuronal networks

    Science.gov (United States)

    Lamb, Damon G; Calabrese, Ronald L

    2013-01-01

    Modeling has contributed a great deal to our understanding of how individual neurons and neuronal networks function. In this review, we focus on models of the small neuronal networks of invertebrates, especially rhythmically active CPG networks. Models have elucidated many aspects of these networks, from identifying key interacting membrane properties to pointing out gaps in our understanding, for example missing neurons. Even the complex CPGs of vertebrates, such as those that underlie respiration, have been reduced to small network models to great effect. Modeling of these networks spans from simplified models, which are amenable to mathematical analyses, to very complicated biophysical models. Some researchers have now adopted a population approach, where they generate and analyze many related models that differ in a few to several judiciously chosen free parameters; often these parameters show variability across animals and thus justify the approach. Models of small neuronal networks will continue to expand and refine our understanding of how neuronal networks in all animals program motor output, process sensory information and learn. PMID:22364687

  4. Small is beautiful: models of small neuronal networks.

    Science.gov (United States)

    Lamb, Damon G; Calabrese, Ronald L

    2012-08-01

    Modeling has contributed a great deal to our understanding of how individual neurons and neuronal networks function. In this review, we focus on models of the small neuronal networks of invertebrates, especially rhythmically active CPG networks. Models have elucidated many aspects of these networks, from identifying key interacting membrane properties to pointing out gaps in our understanding, for example missing neurons. Even the complex CPGs of vertebrates, such as those that underlie respiration, have been reduced to small network models to great effect. Modeling of these networks spans from simplified models, which are amenable to mathematical analyses, to very complicated biophysical models. Some researchers have now adopted a population approach, where they generate and analyze many related models that differ in a few to several judiciously chosen free parameters; often these parameters show variability across animals and thus justify the approach. Models of small neuronal networks will continue to expand and refine our understanding of how neuronal networks in all animals program motor output, process sensory information and learn.

  5. Impact of chemically-modified tetracycline 3 on intertwined physiological, biochemical, and inflammatory networks in porcine sepsis/ARDS

    OpenAIRE

    Sadowsky, David; Nieman, Gary; Barclay, Derek; Mi, Qi; Zamora, Ruben; Constantine, Gregory; Golub, Lorne; Lee, Hsi-Ming; Roy, Shreyas; Gatto, Louis A; Vodovotz, Yoram

    2015-01-01

    Sepsis can lead to multiple organ dysfunction, including the Acute Respiratory Distress Syndrome (ARDS), due to intertwined, dynamic changes in inflammation and organ physiology. We have demonstrated the efficacy of Chemically-Modified Tetracycline 3 (CMT-3) at reducing inflammation and ameliorating pathophysiology in the setting of a clinically realistic porcine model of ARDS. Here, we sought to gain insights into the derangements that characterize sepsis/ARDS and the possible impact of CMT-...

  6. Performance Modeling and Evaluation for Information-Driven Networks

    CERN Document Server

    Wu, Kui; Hu, Guoqiang

    2008-01-01

    Information-driven networks include a large category of networking systems, where network nodes are aware of information delivered and thus can not only forward data packets but may also perform information processing. In many situations, the quality of service (QoS) in information-driven networks is provisioned with the redundancy in information. Traditional performance models generally adopt evaluation measures suitable for packet-oriented service guarantee, such as packet delay, throughput, and packet loss rate. These performance measures, however, do not align well with the actual need of information-driven networks. New performance measures and models for information-driven networks, despite their importance, have been mainly blank, largely because information processing is clearly application dependent and cannot be easily captured within a generic framework. To fill the vacancy, we present a new performance evaluation framework particularly tailored for information-driven networks, based on the recent ...

  7. Runoff Modelling in Urban Storm Drainage by Neural Networks

    DEFF Research Database (Denmark)

    Rasmussen, Michael R.; Brorsen, Michael; Schaarup-Jensen, Kjeld

    1995-01-01

    A neural network is used to simulate folw and water levels in a sewer system. The calibration of th neural network is based on a few measured events and the network is validated against measureed events as well as flow simulated with the MOUSE model (Lindberg and Joergensen, 1986). The neural...... network is used to compute flow or water level at selected points in the sewer system, and to forecast the flow from a small residential area. The main advantages of the neural network are the build-in self calibration procedure and high speed performance, but the neural network cannot be used to extract...... knowledge of the runoff process. The neural network was found to simulate 150 times faster than e.g. the MOUSE model....

  8. Agent-based model of information spread in social networks

    CERN Document Server

    Lande, D V; Berezin, B O

    2016-01-01

    We propose evolution rules of the multiagent network and determine statistical patterns in life cycle of agents - information messages. The main discussed statistical pattern is connected with the number of likes and reposts for a message. This distribution corresponds to Weibull distribution according to modeling results. We examine proposed model using the data from Twitter, an online social networking service.

  9. Optimization model for the design of distributed wastewater treatment networks

    OpenAIRE

    Ibrić Nidret; Ahmetović Elvis; Suljkanović Midhat

    2012-01-01

    In this paper we address the synthesis problem of distributed wastewater networks using mathematical programming approach based on the superstructure optimization. We present a generalized superstructure and optimization model for the design of the distributed wastewater treatment networks. The superstructure includes splitters, treatment units, mixers, with all feasible interconnections including water recirculation. Based on the superstructure the optimization model is presented. The ...

  10. Majority-vote model on Opinion-Dependent Networks

    CERN Document Server

    Lima, F W S

    2013-01-01

    We study a nonequilibrium model with up-down symmetry and a noise parameter $q$ known as majority-vote model of M.J. Oliveira $1992$ on opinion-dependent network or Stauffer-Hohnisch-Pittnauer networks. By Monte Carlo simulations and finite-size scaling relations the critical exponents $\\beta/\

  11. A Versatile Dependent Model for Heterogeneous Cellular Networks

    OpenAIRE

    Haenggi, Martin

    2013-01-01

    We propose a new model for heterogeneous cellular networks that incorporates dependencies between the layers. In particular, it places lower-tier base stations at locations that are poorly covered by the macrocells, and it includes a small-cell model for the case where the goal is to enhance network capacity.

  12. A control model for district heating networks with storage

    NARCIS (Netherlands)

    Scholten, Tjeert; De Persis, Claudio; Tesi, Pietro

    2014-01-01

    In [1] pressure control of hydraulic networks is investigated. We extend this work to district heating systems with storage capabilities and derive a model taking the topology of the network into account. The goal for the derived model is that it should allow for control of the storage level and tem

  13. Communications network design and costing model programmers manual

    Science.gov (United States)

    Logan, K. P.; Somes, S. S.; Clark, C. A.

    1983-01-01

    Otpimization algorithms and techniques used in the communications network design and costing model for least cost route and least cost network problems are examined from the programmer's point of view. All system program modules, the data structures within the model, and the files which make up the data base are described.

  14. A small-world network model of facial emotion recognition.

    Science.gov (United States)

    Takehara, Takuma; Ochiai, Fumio; Suzuki, Naoto

    2016-01-01

    Various models have been proposed to increase understanding of the cognitive basis of facial emotions. Despite those efforts, interactions between facial emotions have received minimal attention. If collective behaviours relating to each facial emotion in the comprehensive cognitive system could be assumed, specific facial emotion relationship patterns might emerge. In this study, we demonstrate that the frameworks of complex networks can effectively capture those patterns. We generate 81 facial emotion images (6 prototypes and 75 morphs) and then ask participants to rate degrees of similarity in 3240 facial emotion pairs in a paired comparison task. A facial emotion network constructed on the basis of similarity clearly forms a small-world network, which features an extremely short average network distance and close connectivity. Further, even if two facial emotions have opposing valences, they are connected within only two steps. In addition, we show that intermediary morphs are crucial for maintaining full network integration, whereas prototypes are not at all important. These results suggest the existence of collective behaviours in the cognitive systems of facial emotions and also describe why people can efficiently recognize facial emotions in terms of information transmission and propagation. For comparison, we construct three simulated networks--one based on the categorical model, one based on the dimensional model, and one random network. The results reveal that small-world connectivity in facial emotion networks is apparently different from those networks, suggesting that a small-world network is the most suitable model for capturing the cognitive basis of facial emotions. PMID:26315136

  15. Mathematical modelling of complex contagion on clustered networks

    Science.gov (United States)

    O'sullivan, David J.; O'Keeffe, Gary; Fennell, Peter; Gleeson, James

    2015-09-01

    The spreading of behavior, such as the adoption of a new innovation, is influenced bythe structure of social networks that interconnect the population. In the experiments of Centola (Science, 2010), adoption of new behavior was shown to spread further and faster across clustered-lattice networks than across corresponding random networks. This implies that the “complex contagion” effects of social reinforcement are important in such diffusion, in contrast to “simple” contagion models of disease-spread which predict that epidemics would grow more efficiently on random networks than on clustered networks. To accurately model complex contagion on clustered networks remains a challenge because the usual assumptions (e.g. of mean-field theory) regarding tree-like networks are invalidated by the presence of triangles in the network; the triangles are, however, crucial to the social reinforcement mechanism, which posits an increased probability of a person adopting behavior that has been adopted by two or more neighbors. In this paper we modify the analytical approach that was introduced by Hebert-Dufresne et al. (Phys. Rev. E, 2010), to study disease-spread on clustered networks. We show how the approximation method can be adapted to a complex contagion model, and confirm the accuracy of the method with numerical simulations. The analytical results of the model enable us to quantify the level of social reinforcement that is required to observe—as in Centola’s experiments—faster diffusion on clustered topologies than on random networks.

  16. A small-world network model of facial emotion recognition.

    Science.gov (United States)

    Takehara, Takuma; Ochiai, Fumio; Suzuki, Naoto

    2016-01-01

    Various models have been proposed to increase understanding of the cognitive basis of facial emotions. Despite those efforts, interactions between facial emotions have received minimal attention. If collective behaviours relating to each facial emotion in the comprehensive cognitive system could be assumed, specific facial emotion relationship patterns might emerge. In this study, we demonstrate that the frameworks of complex networks can effectively capture those patterns. We generate 81 facial emotion images (6 prototypes and 75 morphs) and then ask participants to rate degrees of similarity in 3240 facial emotion pairs in a paired comparison task. A facial emotion network constructed on the basis of similarity clearly forms a small-world network, which features an extremely short average network distance and close connectivity. Further, even if two facial emotions have opposing valences, they are connected within only two steps. In addition, we show that intermediary morphs are crucial for maintaining full network integration, whereas prototypes are not at all important. These results suggest the existence of collective behaviours in the cognitive systems of facial emotions and also describe why people can efficiently recognize facial emotions in terms of information transmission and propagation. For comparison, we construct three simulated networks--one based on the categorical model, one based on the dimensional model, and one random network. The results reveal that small-world connectivity in facial emotion networks is apparently different from those networks, suggesting that a small-world network is the most suitable model for capturing the cognitive basis of facial emotions.

  17. Neural Network Model for the Constitutive Relations of Soil

    Institute of Scientific and Technical Information of China (English)

    Zeng Jing; Wang Jing-tao

    2003-01-01

    The soil constitutive relation is one of the important issues in soil mechanics. It is very difficult to establish mathematical models because of the complexity of soil mechanical behavior. We propose a new method of neural network analysis for establishing soil constitutive models. Based on triaxial experiments of sand in the laboratory, the nonlinear constitutive models of sand expressed by the neural network were set up. In comparison with Duncan-Chang's model, the neural network method for sand modeling has been proved to be more convenient, accurate and it has a strong fault-tolerance function.

  18. Systems and methods for modeling and analyzing networks

    Science.gov (United States)

    Hill, Colin C; Church, Bruce W; McDonagh, Paul D; Khalil, Iya G; Neyarapally, Thomas A; Pitluk, Zachary W

    2013-10-29

    The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity.

  19. Model framework for describing the dynamics of evolving networks

    Science.gov (United States)

    Tobochnik, Jan; Strandburg, Katherine; Csardi, Gabor; Erdi, Peter

    2007-03-01

    We present a model framework for describing the dynamics of evolving networks. In this framework the addition of edges is stochastically governed by some important intrinsic and structural properties of network vertices through an attractiveness function. We discuss the solution of the inverse problem: determining the attractiveness function from the network evolution data. We also present a number of example applications: the description of the US patent citation network using vertex degree, patent age and patent category variables, and we show how the time-dependent version of the method can be used to find and describe important changes in the internal dynamics. We also compare our results to scientific citation networks.

  20. Ocean wave prediction using numerical and neural network models

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.; Prabaharan, N.

    This paper presents an overview of the development of the numerical wave prediction models and recently used neural networks for ocean wave hindcasting and forecasting. The numerical wave models express the physical concepts of the phenomena...

  1. A Novel Trusted Computing Model for Network Security Authentication

    Directory of Open Access Journals (Sweden)

    Ling Xing

    2014-02-01

    Full Text Available Network information poses great threats from malicious attacks due to the openness and virtuality of network structure. Traditional methods to ensure infor- mation security may fail when both integrity and source authentication for information are required. Based on the security of data broadcast channel, a novel Trusted Com- puting Model (TCM of network security authentication is proposed to enhance the security of network information. In this model, a method of Uniform content locator security Digital Certificate (UDC, which is capable of fully and uniquely index network information, is developed. Standard of MPEG-2 Transport Streams (TS is adopted to pack UDC data. Additionally, a UDC hashing algorithm (UHA512 is designed to compute the integrity and security of data infor- mation . Experimental results show that the proposed model is feasible and effective to network security authentication. 

  2. Impulsive Neural Networks Algorithm Based on the Artificial Genome Model

    Directory of Open Access Journals (Sweden)

    Yuan Gao

    2014-05-01

    Full Text Available To describe gene regulatory networks, this article takes the framework of the artificial genome model and proposes impulsive neural networks algorithm based on the artificial genome model. Firstly, the gene expression and the cell division tree are applied to generate spiking neurons with specific attributes, neural network structure, connection weights and specific learning rules of each neuron. Next, the gene segment duplications and divergence model are applied to design the evolutionary algorithm of impulsive neural networks at the level of the artificial genome. The dynamic changes of developmental gene regulatory networks are controlled during the whole evolutionary process. Finally, the behavior of collecting food for autonomous intelligent agent is simulated, which is driven by nerves. Experimental results demonstrate that the algorithm in this article has the evolutionary ability on large-scale impulsive neural networks

  3. Artificial Immune Danger Theory Based Model for Network Security Evaluation

    Directory of Open Access Journals (Sweden)

    Feixian Sun

    2011-02-01

    Full Text Available Inspired by the principles of immune danger theory, a danger theory based model for network security risk assessment is presented in this paper. Firstly, the principle of the danger theory is introduced. And then, with the improved concepts and formal definitions of antigen, antibody, danger signal, and detection lymphocyte for network security risk assessment presented, the distributed architecture of the proposed model is described. Following that, the principle of network intrusion detection is expounded. Finally, the method of network security risk assessment is given. Theoretical analysis and simulation results show that the proposed model can evaluate the network attack threats in real time. Thus, it provides an effective risk evaluation solution to network security.

  4. Energy Consumption Model in Ad Hoc Mobile Network

    Directory of Open Access Journals (Sweden)

    Maher HENI

    2012-06-01

    Full Text Available The aim of this work is to model the nodes battery discharge in wireless ad hoc networks. Many work focus on the energy consumption in such networks. Even, the research in the highest layers of the ISO model, takes into account the energy consumption and efficiency. Indeed, thenodes that form such network are mobiles, so no instant recharge of battery. Also with special type of ad hoc networks are wireless sensors networks using non-rechargeable batteries. All nodes with an exhausted battery are considered death and left the network. To consider the energy consumption, in this work we model using a Markov chain, the discharge of the battery considering of instant activation and deactivation distribution function of these nodes.

  5. River water quality model no. 1 (RWQM1): III. Biochemical submodel selection

    DEFF Research Database (Denmark)

    Vanrolleghem, P.; Borchardt, D.; Henze, Mogens;

    2001-01-01

    The new River Water Quality Model no.1 introduced in the two accompanying papers by Shanahan et al. and Reichert et al. is comprehensive. Shanahan et al. introduced a six-step decision procedure to select the necessary model features for a certain application. This paper specifically addresses one...

  6. A Mathematical Model to Improve the Performance of Logistics Network

    Directory of Open Access Journals (Sweden)

    Muhammad Izman Herdiansyah

    2012-01-01

    Full Text Available The role of logistics nowadays is expanding from just providing transportation and warehousing to offering total integrated logistics. To remain competitive in the global market environment, business enterprises need to improve their logistics operations performance. The improvement will be achieved when we can provide a comprehensive analysis and optimize its network performances. In this paper, a mixed integer linier model for optimizing logistics network performance is developed. It provides a single-product multi-period multi-facilities model, as well as the multi-product concept. The problem is modeled in form of a network flow problem with the main objective to minimize total logistics cost. The problem can be solved using commercial linear programming package like CPLEX or LINDO. Even in small case, the solver in Excel may also be used to solve such model.Keywords: logistics network, integrated model, mathematical programming, network optimization

  7. Role of neural network models for developing speech systems

    Indian Academy of Sciences (India)

    K Sreenivasa Rao

    2011-10-01

    This paper discusses the application of neural networks for developing different speech systems. Prosodic parameters of speech at syllable level depend on positional, contextual and phonological features of the syllables. In this paper, neural networks are explored to model the prosodic parameters of the syllables from their positional, contextual and phonological features. The prosodic parameters considered in this work are duration and sequence of pitch $(F_0)$ values of the syllables. These prosody models are further examined for applications such as text to speech synthesis, speech recognition, speaker recognition and language identification. Neural network models in voice conversion system are explored for capturing the mapping functions between source and target speakers at source, system and prosodic levels. We have also used neural network models for characterizing the emotions present in speech. For identification of dialects in Hindi, neural network models are used to capture the dialect specific information from spectral and prosodic features of speech.

  8. A Network Contention Model for the Extreme-scale Simulator

    Energy Technology Data Exchange (ETDEWEB)

    Engelmann, Christian [ORNL; Naughton III, Thomas J [ORNL

    2015-01-01

    The Extreme-scale Simulator (xSim) is a performance investigation toolkit for high-performance computing (HPC) hardware/software co-design. It permits running a HPC application with millions of concurrent execution threads, while observing its performance in a simulated extreme-scale system. This paper details a newly developed network modeling feature for xSim, eliminating the shortcomings of the existing network modeling capabilities. The approach takes a different path for implementing network contention and bandwidth capacity modeling using a less synchronous and accurate enough model design. With the new network modeling feature, xSim is able to simulate on-chip and on-node networks with reasonable accuracy and overheads.

  9. Underwater Acoustic Networks: Channel Models and Network Coding based Lower Bound to Transmission Power for Multicast

    CERN Document Server

    Lucani, Daniel E; Stojanovic, Milica

    2008-01-01

    The goal of this paper is two-fold. First, to establish a tractable model for the underwater acoustic channel useful for network optimization in terms of convexity. Second, to propose a network coding based lower bound for transmission power in underwater acoustic networks, and compare this bound to the performance of several network layer schemes. The underwater acoustic channel is characterized by a path loss that depends strongly on transmission distance and signal frequency. The exact relationship among power, transmission band, distance and capacity for the Gaussian noise scenario is a complicated one. We provide a closed-form approximate model for 1) transmission power and 2) optimal frequency band to use, as functions of distance and capacity. The model is obtained through numerical evaluation of analytical results that take into account physical models of acoustic propagation loss and ambient noise. Network coding is applied to determine a lower bound to transmission power for a multicast scenario, fo...

  10. New Model of Network- a Future Aspect of the Computer Networks

    CERN Document Server

    Singh, Ram Kumar

    2009-01-01

    As the number and size of the Network increases, the deficiencies persist, including network security problems. But there is no shortage of technologies offered as universal remedy - EIGRP,BGP, OSPF, VoIP, IPv6, IPTV, MPLS, WiFi, to name a few. There are multiple factors for the current situation. Now a day during emergent and blossoming stages of network development is no longer sufficient when the networks are mature and have become everyday tool for social and business interactions. A new model of network is necessary to find solutions for today's pressing problems, especially those related to network security. In this paper out factors leading to current stagnation discusses critical assumptions behind current networks, how many of them are no longer valid and have become barriers for implementing real solutions. The paper concludes by offering new directions for future needs and solving current challenges.

  11. A comprehensive multi-local-world model for complex networks

    International Nuclear Information System (INIS)

    The nodes in a community within a network are much more connected to each other than to the others outside the community in the same network. This phenomenon has been commonly observed from many real-world networks, ranging from social to biological even to technical networks. Meanwhile, the number of communities in some real-world networks, such as the Internet and most social networks, are evolving with time. To model this kind of networks, the present Letter proposes a multi-local-world (MLW) model to capture and describe their essential topological properties. Based on the mean-field theory, the degree distribution of this model is obtained analytically, showing that the generated network has a novel topological feature as being not completely random nor completely scale-free but behaving somewhere between them. As a typical application, the MLW model is applied to characterize the Internet against some other models such as the BA, GBA, Fitness and HOT models, demonstrating the superiority of the new model.

  12. A comprehensive multi-local-world model for complex networks

    Energy Technology Data Exchange (ETDEWEB)

    Fan Zhengping [Department of Automation, Sun Yat-sen University, Guangzhou 510275 (China); Chen Guanrong [Department of Electronic and Engineering, City University of Hong Kong, Hong Kong (China)], E-mail: eegchen@cityu.edu.hk; Zhang Yunong [Department of Automation, Sun Yat-sen University, Guangzhou 510275 (China)

    2009-04-20

    The nodes in a community within a network are much more connected to each other than to the others outside the community in the same network. This phenomenon has been commonly observed from many real-world networks, ranging from social to biological even to technical networks. Meanwhile, the number of communities in some real-world networks, such as the Internet and most social networks, are evolving with time. To model this kind of networks, the present Letter proposes a multi-local-world (MLW) model to capture and describe their essential topological properties. Based on the mean-field theory, the degree distribution of this model is obtained analytically, showing that the generated network has a novel topological feature as being not completely random nor completely scale-free but behaving somewhere between them. As a typical application, the MLW model is applied to characterize the Internet against some other models such as the BA, GBA, Fitness and HOT models, demonstrating the superiority of the new model.

  13. Programming Sensor Networks Using Remora Component Model

    Science.gov (United States)

    Taherkordi, Amirhosein; Loiret, Frédéric; Abdolrazaghi, Azadeh; Rouvoy, Romain; Le-Trung, Quan; Eliassen, Frank

    The success of high-level programming models in Wireless Sensor Networks (WSNs) is heavily dependent on factors such as ease of programming, code well-structuring, degree of code reusability, and required software development effort. Component-based programming has been recognized as an effective approach to meet such requirements. Most of componentization efforts in WSNs were ineffective due to various reasons, such as high resource demand or limited scope of use. In this paper, we present Remora, a new approach to practical and efficient component-based programming in WSNs. Remora offers a well-structured programming paradigm that fits very well with resource limitations of embedded systems, including WSNs. Furthermore, the special attention to event handling in Remora makes our proposal more practical for WSN applications, which are inherently event-driven. More importantly, the mutualism between Remora and underlying system software promises a new direction towards separation of concerns in WSNs. Our evaluation results show that a well-configured Remora application has an acceptable memory overhead and a negligible CPU cost.

  14. Modelling celullar communication with scale-free networks.

    Science.gov (United States)

    Dobrescu, Radu; Purcărea, Victor

    2008-01-01

    The paper proposes a model that brings to light the characteristics of several complex systems having similar scale-free network architecture. The properties of this kind of network are compared with those of other methods which are specific for studying complex systems: nonlinear dynamics and statistical methods. We place particular emphasis on scale-free network theory and its importance in enhancing the framework for the quantitative study of complex biological systems. The advantages and limits in understanding the structure of cellular signaling networks of this model are finally discussed. PMID:20108462

  15. Reliability Modeling and Analysis of SCI Topological Network

    Directory of Open Access Journals (Sweden)

    Hongzhe Xu

    2012-03-01

    Full Text Available The problem of reliability modeling on the Scalable Coherent Interface (SCI rings and topological network is studied. The reliability models of three SCI rings are developed and the factors which influence the reliability of SCI rings are studied. By calculating the shortest path matrix and the path quantity matrix of different types SCI network topology, the communication characteristics of SCI network are obtained. For the situations of the node-damage and edge-damage, the survivability of SCI topological network is studied.

  16. Simulation Model of Magnetic Levitation Based on NARX Neural Networks

    Directory of Open Access Journals (Sweden)

    Dragan Antić

    2013-04-01

    Full Text Available In this paper, we present analysis of different training types for nonlinear autoregressive neural network, used for simulation of magnetic levitation system. First, the model of this highly nonlinear system is described and after that the Nonlinear Auto Regressive eXogenous (NARX of neural network model is given. Also, numerical optimization techniques for improved network training are described. It is verified that NARX neural network can be successfully used to simulate real magnetic levitation system if suitable training procedure is chosen, and the best two training types, obtained from experimental results, are described in details.

  17. An Extended Hierarchical Trusted Model for Wireless Sensor Networks

    Institute of Scientific and Technical Information of China (English)

    DU Ruiying; XU Mingdi; ZHANG Huanguo

    2006-01-01

    Cryptography and authentication are traditional approach for providing network security. However, they are not sufficient for solving the problems which malicious nodes compromise whole wireless sensor network leading to invalid data transmission and wasting resource by using vicious behaviors. This paper puts forward an extended hierarchical trusted architecture for wireless sensor network, and establishes trusted congregations by three-tier framework. The method combines statistics, economics with encrypt mechanism for developing two trusted models which evaluate cluster head nodes and common sensor nodes respectively. The models form logical trusted-link from command node to common sensor nodes and guarantees the network can run in secure and reliable circumstance.

  18. Synchronization in a Novel Local-World Dynamical Network Model

    Directory of Open Access Journals (Sweden)

    Jianeng Tang

    2014-01-01

    Full Text Available Advances in complex network research have recently stimulated increasing interests in understanding the relationship between the topology and dynamics of complex networks. In the paper, we study the synchronizability of a class of local-world dynamical networks. Then, we have proposed a local-world synchronization-optimal growth topology model. Compared with the local-world evolving network model, it exhibits a stronger synchronizability. We also investigate the robustness of the synchronizability with respect to random failures and the fragility of the synchronizability with specific removal of nodes.

  19. Trust Model Based on P2P Network

    Directory of Open Access Journals (Sweden)

    Guang Ouyang

    2013-09-01

    Full Text Available In order to change the defect of traditional trust model, the research on trust model based on P2P network is proposed in this paper. It is based on the theoretical characteristic of P2P network and analyzes the trust mechanism and application model and set up a kind of new trust model. This kind of trust model is great helpful to improve the success rate of transaction and the trust model was designed. Finally, the simulation experiment is made. The results show that using P2P trust model can be more effectively inhibit and isolate the malicious nodes than the other and improving PZP network environment can make the network gets a benign development.

  20. Network Statistical Models for Language Learning Contexts: Exponential Random Graph Models and Willingness to Communicate

    Science.gov (United States)

    Gallagher, H. Colin; Robins, Garry

    2015-01-01

    As part of the shift within second language acquisition (SLA) research toward complex systems thinking, researchers have called for investigations of social network structure. One strand of social network analysis yet to receive attention in SLA is network statistical models, whereby networks are explained in terms of smaller substructures of…

  1. Transcriptional Network growing Models using Motif-based Preferential Attachment

    Directory of Open Access Journals (Sweden)

    Ahmed Farouk Abdelzaher

    2015-10-01

    Full Text Available Understanding relationships between architectural properties of gene-regulatory networks (GRNs has been one of the major goals in systems biology and bioinformatics, as it can provide insights into, e.g., disease dynamics and drug development. Such GRNs are characterized by their scale-free degree distributions and existence of network motifs--i.e., small-node subgraphs that occur more abundantly in GRNs than expected from chance alone. Because these transcriptional modules represent ``building blocks'' of complex networks and exhibit a wide range of functional and dynamical properties, they may contribute to the remarkable robustness and dynamical stability associated with the whole of GRNs. Here we developed network-construction models to better understand this relationship, which produce randomized GRNs by using transcriptional motifs as the fundamental growth unit in contrast to other methods that construct similar networks on a node-by-node basis. Because this model produces networks with a prescribed lower bound on the number of choice transcriptional motifs (e.g., downlinks, feed-forward loops, its fidelity to the motif distributions observed in model organisms represents an improvement over existing methods, which we validated by contrasting their resultant motif and degree distributions against existing network-growth models and data from the model organism of the bacterium Escherichia coli. These models may therefore serve as novel testbeds for further elucidating relationships between the topology of transcriptional motifs and network-wide dynamical properties.

  2. BP Network Based Users' Interest Model in Mining WWW Cache

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    By analyzing the WWW Cache model, we bring forward a user-interest description method based on the fuzzy theory and user-interest inferential relations based on BP(back propagation) neural network. By this method, the users' interest in the WWW cache can be described and the neural network of users' interest can be constructed by positive spread of interest and the negative spread of errors. This neural network can infer the users' interest. This model is not the simple extension of the simple interest model, but the round improvement of the model and its related algorithm.

  3. Modeling the propagation of mobile malware on complex networks

    Science.gov (United States)

    Liu, Wanping; Liu, Chao; Yang, Zheng; Liu, Xiaoyang; Zhang, Yihao; Wei, Zuxue

    2016-08-01

    In this paper, the spreading behavior of malware across mobile devices is addressed. By introducing complex networks to model mobile networks, which follows the power-law degree distribution, a novel epidemic model for mobile malware propagation is proposed. The spreading threshold that guarantees the dynamics of the model is calculated. Theoretically, the asymptotic stability of the malware-free equilibrium is confirmed when the threshold is below the unity, and the global stability is further proved under some sufficient conditions. The influences of different model parameters as well as the network topology on malware propagation are also analyzed. Our theoretical studies and numerical simulations show that networks with higher heterogeneity conduce to the diffusion of malware, and complex networks with lower power-law exponents benefit malware spreading.

  4. Dissipative electro-elastic network model of protein electrostatics

    CERN Document Server

    Martin, Daniel R; Matyushov, Dmitry V

    2011-01-01

    We propose a dissipative electro-elastic network model (DENM) to describe the dynamics and statistics of electrostatic fluctuations at active sites of proteins. The model combines the harmonic network of residue beads with overdamped dynamics of the normal modes of the network characterized by two friction coefficients. The electrostatic component is introduced to the model through atomic charges of the protein force field. The overall effect of the electrostatic fluctuations of the network is recorded through the frequency-dependent response functions of the electrostatic potential and electric field at the active site. We also consider the dynamics of displacements of individual residues in the network and the dynamics of distances between pairs of residues. The model is tested against loss spectra of residue displacements and the electrostatic potential and electric field at the heme's iron from all-atom molecular dynamics simulations of three hydrated globular proteins.

  5. SPLAI: Computational Finite Element Model for Sensor Networks

    Directory of Open Access Journals (Sweden)

    Ruzana Ishak

    2006-01-01

    Full Text Available Wireless sensor network refers to a group of sensors, linked by a wireless medium to perform distributed sensing task. The primary interest is their capability in monitoring the physical environment through the deployment of numerous tiny, intelligent, wireless networked sensor nodes. Our interest consists of a sensor network, which includes a few specialized nodes called processing elements that can perform some limited computational capabilities. In this paper, we propose a model called SPLAI that allows the network to compute a finite element problem where the processing elements are modeled as the nodes in the linear triangular approximation problem. Our model also considers the case of some failures of the sensors. A simulation model to visualize this network has been developed using C++ on the Windows environment.

  6. Network Inoculation: Heteroclinics and phase transitions in an epidemic model

    CERN Document Server

    Yang, Hui; Gross, Thilo

    2016-01-01

    In epidemiological modelling, dynamics on networks, and in particular adaptive and heterogeneous networks have recently received much interest. Here we present a detailed analysis of a previously proposed model that combines heterogeneity in the individuals with adaptive rewiring of the network structure in response to a disease. We show that in this model qualitative changes in the dynamics occur in two phase transitions. In a macroscopic description one of these corresponds to a local bifurcation whereas the other one corresponds to a non-local heteroclinic bifurcation. This model thus provides a rare example of a system where a phase transition is caused by a non-local bifurcation, while both micro- and macro-level dynamics are accessible to mathematical analysis. The bifurcation points mark the onset of a behaviour that we call network inoculation. In the respective parameter region exposure of the system to a pathogen will lead to an outbreak that collapses, but leaves the network in a configuration wher...

  7. A novel interacting multiple model based network intrusion detection scheme

    Science.gov (United States)

    Xin, Ruichi; Venkatasubramanian, Vijay; Leung, Henry

    2006-04-01

    In today's information age, information and network security are of primary importance to any organization. Network intrusion is a serious threat to security of computers and data networks. In internet protocol (IP) based network, intrusions originate in different kinds of packets/messages contained in the open system interconnection (OSI) layer 3 or higher layers. Network intrusion detection and prevention systems observe the layer 3 packets (or layer 4 to 7 messages) to screen for intrusions and security threats. Signature based methods use a pre-existing database that document intrusion patterns as perceived in the layer 3 to 7 protocol traffics and match the incoming traffic for potential intrusion attacks. Alternately, network traffic data can be modeled and any huge anomaly from the established traffic pattern can be detected as network intrusion. The latter method, also known as anomaly based detection is gaining popularity for its versatility in learning new patterns and discovering new attacks. It is apparent that for a reliable performance, an accurate model of the network data needs to be established. In this paper, we illustrate using collected data that network traffic is seldom stationary. We propose the use of multiple models to accurately represent the traffic data. The improvement in reliability of the proposed model is verified by measuring the detection and false alarm rates on several datasets.

  8. Random field Ising model and community structure in complex networks

    Science.gov (United States)

    Son, S.-W.; Jeong, H.; Noh, J. D.

    2006-04-01

    We propose a method to determine the community structure of a complex network. In this method the ground state problem of a ferromagnetic random field Ising model is considered on the network with the magnetic field Bs = +∞, Bt = -∞, and Bi≠s,t=0 for a node pair s and t. The ground state problem is equivalent to the so-called maximum flow problem, which can be solved exactly numerically with the help of a combinatorial optimization algorithm. The community structure is then identified from the ground state Ising spin domains for all pairs of s and t. Our method provides a criterion for the existence of the community structure, and is applicable equally well to unweighted and weighted networks. We demonstrate the performance of the method by applying it to the Barabási-Albert network, Zachary karate club network, the scientific collaboration network, and the stock price correlation network. (Ising, Potts, etc.)

  9. Wavelet Based Analytical Expressions to Steady State Biofilm Model Arising in Biochemical Engineering.

    Science.gov (United States)

    Padma, S; Hariharan, G

    2016-06-01

    In this paper, we have developed an efficient wavelet based approximation method to biofilm model under steady state arising in enzyme kinetics. Chebyshev wavelet based approximation method is successfully introduced in solving nonlinear steady state biofilm reaction model. To the best of our knowledge, until now there is no rigorous wavelet based solution has been addressed for the proposed model. Analytical solutions for substrate concentration have been derived for all values of the parameters δ and SL. The power of the manageable method is confirmed. Some numerical examples are presented to demonstrate the validity and applicability of the wavelet method. Moreover the use of Chebyshev wavelets is found to be simple, efficient, flexible, convenient, small computation costs and computationally attractive. PMID:26661721

  10. Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis.

    Science.gov (United States)

    Lenka, Sangram K; Carbonaro, Nicole; Park, Rudolph; Miller, Stephen M; Thorpe, Ian; Li, Yantao

    2016-01-01

    Triacylglycerols (TAGs) are highly reduced energy storage molecules ideal for biodiesel production. Microalgal TAG biosynthesis has been studied extensively in recent years, both at the molecular level and systems level through experimental studies and computational modeling. However, discussions of the strategies and products of the experimental and modeling approaches are rarely integrated and summarized together in a way that promotes collaboration among modelers and biologists in this field. In this review, we outline advances toward understanding the cellular and molecular factors regulating TAG biosynthesis in unicellular microalgae with an emphasis on recent studies on rate-limiting steps in fatty acid and TAG synthesis, while also highlighting new insights obtained from the integration of multi-omics datasets with mathematical models. Computational methodologies such as kinetic modeling, metabolic flux analysis, and new variants of flux balance analysis are explained in detail. We discuss how these methods have been used to simulate algae growth and lipid metabolism in response to changing culture conditions and how they have been used in conjunction with experimental validations. Since emerging evidence indicates that TAG synthesis in microalgae operates through coordinated crosstalk between multiple pathways in diverse subcellular destinations including the endoplasmic reticulum and plastids, we discuss new experimental studies and models that incorporate these findings for discovering key regulatory checkpoints. Finally, we describe tools for genetic manipulation of microalgae and their potential for future rational algal strain design. This comprehensive review explores the potential synergistic impact of pathway analysis, computational approaches, and molecular genetic manipulation strategies on improving TAG production in microalgae.

  11. Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis.

    Science.gov (United States)

    Lenka, Sangram K; Carbonaro, Nicole; Park, Rudolph; Miller, Stephen M; Thorpe, Ian; Li, Yantao

    2016-01-01

    Triacylglycerols (TAGs) are highly reduced energy storage molecules ideal for biodiesel production. Microalgal TAG biosynthesis has been studied extensively in recent years, both at the molecular level and systems level through experimental studies and computational modeling. However, discussions of the strategies and products of the experimental and modeling approaches are rarely integrated and summarized together in a way that promotes collaboration among modelers and biologists in this field. In this review, we outline advances toward understanding the cellular and molecular factors regulating TAG biosynthesis in unicellular microalgae with an emphasis on recent studies on rate-limiting steps in fatty acid and TAG synthesis, while also highlighting new insights obtained from the integration of multi-omics datasets with mathematical models. Computational methodologies such as kinetic modeling, metabolic flux analysis, and new variants of flux balance analysis are explained in detail. We discuss how these methods have been used to simulate algae growth and lipid metabolism in response to changing culture conditions and how they have been used in conjunction with experimental validations. Since emerging evidence indicates that TAG synthesis in microalgae operates through coordinated crosstalk between multiple pathways in diverse subcellular destinations including the endoplasmic reticulum and plastids, we discuss new experimental studies and models that incorporate these findings for discovering key regulatory checkpoints. Finally, we describe tools for genetic manipulation of microalgae and their potential for future rational algal strain design. This comprehensive review explores the potential synergistic impact of pathway analysis, computational approaches, and molecular genetic manipulation strategies on improving TAG production in microalgae. PMID:27321475

  12. Neural-networks-based Modelling and a Fuzzy Neural Networks Controller of MCFC

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Molten Carbonate Fuel Cells (MCFC) are produced with a highly efficient and clean power generation technology which will soon be widely utilized. The temperature characters of MCFC stack are briefly analyzed. A radial basis function (RBF) neural networks identification technology is applied to set up the temperature nonlinear model of MCFC stack, and the identification structure, algorithm and modeling training process are given in detail. A fuzzy controller of MCFC stack is designed. In order to improve its online control ability, a neural network trained by the I/O data of a fuzzy controller is designed. The neural networks can memorize and expand the inference rules of the fuzzy controller and substitute for the fuzzy controller to control MCFC stack online. A detailed design of the controller is given. The validity of MCFC stack modelling based on neural networks and the superior performance of the fuzzy neural networks controller are proved by Simulations.

  13. Uniformed model of networked control systems with long time delay

    Institute of Scientific and Technical Information of China (English)

    Zhu Qixin; Liu Hongli; Hu Shousong

    2008-01-01

    Feedback control systems wherein the control loops are closed through a real-time network are called networked control systems (NCS). The defining feature of an NCS is that information is exchanged using a network among control system components. Two new concepts including long time delay and short time delay are proposed.The sensor is almost always clock driven. The controller or the actuator is either clock driven or event driven. Four possible driving modes of networked control systems are presented. The open loop mathematic models of networked control systems with long time delay are developed when the system is driven by anyone of the four different modes.The uniformed modeling method of networked control systems with long time delay is proposed. The simulation results are given in the end.

  14. A mixing evolution model for bidirectional microblog user networks

    Science.gov (United States)

    Yuan, Wei-Guo; Liu, Yun

    2015-08-01

    Microblogs have been widely used as a new form of online social networking. Based on the user profile data collected from Sina Weibo, we find that the number of microblog user bidirectional friends approximately corresponds with the lognormal distribution. We then build two microblog user networks with real bidirectional relationships, both of which have not only small-world and scale-free but also some special properties, such as double power-law degree distribution, disassortative network, hierarchical and rich-club structure. Moreover, by detecting the community structures of the two real networks, we find both of their community scales follow an exponential distribution. Based on the empirical analysis, we present a novel evolution network model with mixed connection rules, including lognormal fitness preferential and random attachment, nearest neighbor interconnected in the same community, and global random associations in different communities. The simulation results show that our model is consistent with real network in many topology features.

  15. Stochastic modeling of biochemical systems with multistep reactions using state-dependent time delay.

    Science.gov (United States)

    Wu, Qianqian; Tian, Tianhai

    2016-01-01

    To deal with the growing scale of molecular systems, sophisticated modelling techniques have been designed in recent years to reduce the complexity of mathematical models. Among them, a widely used approach is delayed reaction for simplifying multistep reactions. However, recent research results suggest that a delayed reaction with constant time delay is unable to describe multistep reactions accurately. To address this issue, we propose a novel approach using state-dependent time delay to approximate multistep reactions. We first use stochastic simulations to calculate time delay arising from multistep reactions exactly. Then we design algorithms to calculate time delay based on system dynamics precisely. To demonstrate the power of proposed method, two processes of mRNA degradation are used to investigate the function of time delay in determining system dynamics. In addition, a multistep pathway of metabolic synthesis is used to explore the potential of the proposed method to simplify multistep reactions with nonlinear reaction rates. Simulation results suggest that the state-dependent time delay is a promising and accurate approach to reduce model complexity and decrease the number of unknown parameters in the models. PMID:27553753

  16. Zymomonas mobilis as a Model System for Production of Biofuels and Biochemicals

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shihui; Fei, Qiang; Zhang, Yaoping; Contreras, Lydia M.; Utturkar, Sagar M.; Brown, Steven D.; Himmel, Michael E.; Zhang, Min

    2016-11-01

    Zymomonas mobilis is a natural ethanologen with many desirable industrial biocatalyst characteristics. In this review, we will discuss work to develop Z. mobilis as a model system for biofuel production from the perspectives of substrate utilization, development for industrial robustness, potential product spectrum, strain evaluation and fermentation strategies. This review also encompasses perspectives related to classical genetic tools and emerging technologies in this context.

  17. Multiscale Gaussian network model (mGNM) and multiscale anisotropic network model (mANM).

    Science.gov (United States)

    Xia, Kelin; Opron, Kristopher; Wei, Guo-Wei

    2015-11-28

    Gaussian network model (GNM) and anisotropic network model (ANM) are some of the most popular methods for the study of protein flexibility and related functions. In this work, we propose generalized GNM (gGNM) and ANM methods and show that the GNM Kirchhoff matrix can be built from the ideal low-pass filter, which is a special case of a wide class of correlation functions underpinning the linear scaling flexibility-rigidity index (FRI) method. Based on the mathematical structure of correlation functions, we propose a unified framework to construct generalized Kirchhoff matrices whose matrix inverse leads to gGNMs, whereas, the direct inverse of its diagonal elements gives rise to FRI method. With this connection, we further introduce two multiscale elastic network models, namely, multiscale GNM (mGNM) and multiscale ANM (mANM), which are able to incorporate different scales into the generalized Kirchhoff matrices or generalized Hessian matrices. We validate our new multiscale methods with extensive numerical experiments. We illustrate that gGNMs outperform the original GNM method in the B-factor prediction of a set of 364 proteins. We demonstrate that for a given correlation function, FRI and gGNM methods provide essentially identical B-factor predictions when the scale value in the correlation function is sufficiently large. More importantly, we reveal intrinsic multiscale behavior in protein structures. The proposed mGNM and mANM are able to capture this multiscale behavior and thus give rise to a significant improvement of more than 11% in B-factor predictions over the original GNM and ANM methods. We further demonstrate the benefits of our mGNM through the B-factor predictions of many proteins that fail the original GNM method. We show that the proposed mGNM can also be used to analyze protein domain separations. Finally, we showcase the ability of our mANM for the analysis of protein collective motions. PMID:26627949

  18. Exponential-Family Random Graph Models for Valued Networks

    CERN Document Server

    Krivitsky, Pavel N

    2011-01-01

    Exponential-family random graph models (ERGMs) provide a principled and flexible way to model and simulate features common in social networks, such as propensities for homophily, mutuality, and friend-of-a-friend triad closure, through choice of model terms (sufficient statistics). However, those ERGMs modeling the more complex features have, to date, been limited to binary data: presence or absence of ties. Thus, analysis of valued networks, such as those where counts, measurements, or ranks are observed, has necessitated dichotomizing them, losing information. In this work, we generalize ERGMs to valued networks. Using the concept of reference measures, we describe a rigorous yet intuitive framework that retains many of the inferential and interpretability properties of the binary case, and discuss additional issues and caveats that emerge. Focusing on modeling counts, we introduce terms that generalize and model common social network features for count data, while avoiding degeneracy. We apply these method...

  19. Analysis and Comparison of Typical Models within Distribution Network Design

    DEFF Research Database (Denmark)

    Jørgensen, Hans Jacob; Larsen, Allan; Madsen, Oli B.G.

    This paper investigates the characteristics of typical optimisation models within Distribution Network Design. During the paper fourteen models known from the literature will be thoroughly analysed. Through this analysis a schematic approach to categorisation of distribution network design models...... for educational purposes. Furthermore, the paper can be seen as a practical introduction to network design modelling as well as a being an art manual or recipe when constructing such a model....... are covered in the categorisation include fixed vs. general networks, specialised vs. general nodes, linear vs. nonlinear costs, single vs. multi commodity, uncapacitated vs. capacitated activities, single vs. multi modal and static vs. dynamic. The models examined address both strategic and tactical planning...

  20. Model of Trust Management in Open Network Environment

    Institute of Scientific and Technical Information of China (English)

    曹元大; 宁宇鹏

    2003-01-01

    To keep open network more efficacious and secure, it is necessary that a nice trust model and method of trust management must be developed. The reason why traditional trust models are incomplete in their function to manage trust is explained, and a general model based on hybrid trust model and introducer protocol is provided. The hybrid model is more flexible and efficacious to manage trust compared with hierarchy model and Web model. The introducer protocol is a better solution to build, maintain and refresh the trust relationship in open network environment.

  1. Linear approximation model network and its formation via evolutionary computation

    Indian Academy of Sciences (India)

    Yun Li; Kay Chen Tan

    2000-04-01

    To overcome the deficiency of `local model network' (LMN) techniques, an alternative `linear approximation model' (LAM) network approach is proposed. Such a network models a nonlinear or practical system with multiple linear models fitted along operating trajectories, where individual models are simply networked through output or parameter interpolation. The linear models are valid for the entire operating trajectory and hence overcome the local validity of LMN models, which impose the predetermination of a scheduling variable that predicts characteristic changes of the nonlinear system. LAMs can be evolved fromsampled step response data directly, eliminating the need forlocal linearisation upon a pre-model using derivatives of the nonlinear system. The structural difference between a LAM network and an LMN isthat the overall model of the latteris a parameter-varying system and hence nonlinear,while the formerremains linear time-invariant (LTI). Hence, existing LTI and transfer function theory applies to a LAM network, which is therefore easy to use for control system design. Validation results show that the proposed method offers a simple, transparent and accurate multivariable modelling technique for nonlinear systems.

  2. A Semantic Model for Enhancing Network Services Management and Auditing

    OpenAIRE

    Rodrigues, Carlos; Carvalho, Paulo; Álvarez-Sabucedo, Luis M.; Lima, Solange

    2011-01-01

    The road toward ubiquity, heterogeneity and virtualization of network services and resources urges for a formal and systematic approach to network management tasks. In particular, the semantic characterization and modeling of services provided to users assume an essential role in fostering autonomic service management, service negotiation and auditing. This paper is centered on the definition of an ontology for multiservice IP networks which intends to address multiple service managemen...

  3. Chimera in a neuronal network model of the cat brain

    OpenAIRE

    Santos, M. S.; Szezech Jr., J. D.; Borges, F. S.; Iarosz, K. C.; Caldas, I. L.; Batista, A. M.; Viana, R. L.; Kurths, J.

    2016-01-01

    Neuronal systems have been modeled by complex networks in different description levels. Recently, it has been verified that networks can simultaneously exhibit one coherent and other incoherent domain, known as chimera states. In this work, we study the existence of chimera states in a network considering the connectivity matrix based on the cat cerebral cortex. The cerebral cortex of the cat can be separated in 65 cortical areas organised into the four cognitive regions: visual, auditory, so...

  4. Network Proactive Defense Model Based on Immune Danger Theory

    OpenAIRE

    Zhenxing Wang; Liancheng Zhang; Yazhou Kong; Yu Wang

    2016-01-01

    Recent investigations into proactive network defense have not produced a systematic methodology and structure; in addition, issues including multi-source information fusion and attacking behavior analysis have not been resolved. Borrowing ideas of danger sensing and immune response from danger theory, a proactive network defense model based on danger theory is proposed. This paper defines the signals and antigens in the network environment as well as attacking behavior analysis algorithm, pro...

  5. Modeling Self-Similar Traffic for Network Simulation

    OpenAIRE

    Bai, Xiaofeng; Shami, Abdallah

    2013-01-01

    In order to closely simulate the real network scenario thereby verify the effectiveness of protocol designs, it is necessary to model the traffic flows carried over realistic networks. Extensive studies [1] showed that the actual traffic in access and local area networks (e.g., those generated by ftp and video streams) exhibits the property of self-similarity and long-range dependency (LRD) [2]. In this appendix we briefly introduce the property of self-similarity and suggest a practical appr...

  6. Ongoing Processes in a Fitness Network Model under Restricted Resources.

    Directory of Open Access Journals (Sweden)

    Takayuki Niizato

    Full Text Available In real networks, the resources that make up the nodes and edges are finite. This constraint poses a serious problem for network modeling, namely, the compatibility between robustness and efficiency. However, these concepts are generally in conflict with each other. In this study, we propose a new fitness-driven network model for finite resources. In our model, each individual has its own fitness, which it tries to increase. The main assumption in fitness-driven networks is that incomplete estimation of fitness results in a dynamical growing network. By taking into account these internal dynamics, nodes and edges emerge as a result of exchanges between finite resources. We show that our network model exhibits exponential distributions in the in- and out-degree distributions and a power law distribution of edge weights. Furthermore, our network model resolves the trade-off relationship between robustness and efficiency. Our result suggests that growing and anti-growing networks are the result of resolving the trade-off problem itself.

  7. TCP-IP Model in Data Communication and Networking

    Directory of Open Access Journals (Sweden)

    Pranab Bandhu Nath

    2015-10-01

    Full Text Available The Internet protocol suite is the computer networking model and set of communications protocols used on the Internet and similar computer networks. It is commonly known as TCP/IP, because it’s most important protocols, the Transmission Control Protocol (TCP and the Internet Protocol (IP, were the first networking protocols defined in this standard. Often also called the Internet model, it was originally also known as the DoD model, because the development of the networking model was funded by DARPA, an agency of the United States Department of Defense. TCP/IP provides end-to-end connectivity specifying how data should be packetized, addressed, transmitted, routed and received at the destination. This functionality is organized into four abstraction layers which are used to sort all related protocols according to the scope of networking involved. From lowest to highest, the layers are the link layer, containing communication technologies for a single network segment (link; the internet layer, connecting hosts across independent networks, thus establishing internetworking; the transport layer handling host-to-host communication; and the application layer, which provides process-to-process application data exchange. Our aim is describe operation & models of TCP-IP suite in data communication networking

  8. Congestion Control Avoidance in ADHOC Network using Queuing Model

    Directory of Open Access Journals (Sweden)

    G.Vijaya Lakshmi

    2011-07-01

    Full Text Available Mobile adhoc network is an emerging standard or wireless communication. Due to the impendence in infrastructure dependencies these networks are rapidly emerging. These networks are since evolving has to develop methodologies for the compatibility of current services in such an environment. Various services compatibilities were studied and methodologies were proposed for the same. One basic problem observed during the incorporation of services in adhoc network is the traffic flow, and its proper modeling. As the demanded service increases the variability in the links increases. Due to the dynamicity of the link factors there are various issues been observed, in which congestion is one of the problem.Congestion is caused when the offered load to the network is more than the available resources. To overcome the congestion problem in mobile adhoc network a queuing model is suggested in the current work. The queuing mechanism is developed based on the probability distribution in different range of communication. The queuing mechanism hence improves the network metrics such as overall network throughput, reduces the route delay, overhead and traffic blockage probability. The approach is generated over a routing scheme in adhoc network. A Matlab simulation is developed for the suggested approach and evaluated for multiple network environments to evaluate the system performance

  9. Multilevel security model for ad hoc networks

    Institute of Scientific and Technical Information of China (English)

    Wang Changda; Ju Shiguang

    2008-01-01

    Modern battlefield doctrine is based on mobility, flexibility, and rapid response to changing situations.As is well known, mobile ad hoc network systems are among the best utilities for battlefield activity. Although much research has been done on secure routing, security issues have largely been ignored in applying mobile ad hoc network theory to computer technology. An ad hoc network is usually assumed to be homogeneous, which is an irrational assumption for armies. It is clear that soldiers, commanders, and commanders-in-chief should have different security levels and computation powers as they have access to asymmetric resources. Imitating basic military rank levels in battlefield situations, how multilevel security can be introduced into ad hoc networks is indicated, thereby controlling restricted classified information flows among nodes that have different security levels.

  10. Renormalization group analysis of the small-world network model

    OpenAIRE

    Newman, M. E. J.; Watts, D. J.

    1999-01-01

    We study the small-world network model, which mimics the transition between regular-lattice and random-lattice behavior in social networks of increasing size. We contend that the model displays a normal continuous phase transition with a divergent correlation length as the degree of randomness tends to zero. We propose a real-space renormalization group transformation for the model and demonstrate that the transformation is exact in the limit of large system size. We use this result to calcul...

  11. ANALYSIS OF ORGANIZATIONAL CULTURE WITH SOCIAL NETWORK MODELS

    OpenAIRE

    Titov, S.

    2015-01-01

    Organizational culture is nowadays an object of numerous scientific papers. However, only marginal part of existing research attempts to use the formal models of organizational cultures. The lack of organizational culture models significantly limits the further research in this area and restricts the application of the theory to practice of organizational culture change projects. The article consists of general views on potential application of network models and social network analysis to th...

  12. Degree distribution of a new model for evolving networks

    Indian Academy of Sciences (India)

    Xuan Zhang; Qinggui Zhao

    2010-03-01

    We propose and study an evolving network model with both preferential and random attachments of new links, incorporating the addition of new nodes, new links, and the removal of links. We first show that the degree evolution of a node follows a nonhomogeneous Markov chain. Based on the concept of Markov chain, we provide the exact solution of the degree distribution of this model and show that the model can generate scale-free evolving network.

  13. Teletraffic Models for Mobile Network Connectivity.

    OpenAIRE

    Venigalla, Thejaswi; Akkapaka, Raj Kiran

    2013-01-01

    We are in an era marked by tremendous global growth in mobile traffic and subscribers due to change in the mobile communication technology from second generation to third and fourth generations. Especially usage of packet-data applications has recorded remarkable growth. The need for mobile communication networks capable of providing an ever increasing spectrum of services calls for efficient techniques for the analysis, monitoring and design of networks. To meet the ever increasing demands o...

  14. A biochemical model of photosynthesis for mango leaves: evidence for the effect of fruit on photosynthetic capacity of nearby leaves.

    Science.gov (United States)

    Urban, L; Le Roux, X; Sinoquet, H; Jaffuel, S; Jannoyer, M

    2003-04-01

    Variations in leaf nitrogen concentration per unit mass (Nm) and per unit area (Na), mass-to-area ratio (Ma), total nonstructural carbohydrates (Ta), and photosynthetic capacity (maximum carboxylation rate, electron transport capacity, rate of phosphate release in triose phosphate utilization and dark respiration rate) were studied within the digitized crowns of two 3-year-old mango trees (Mangifera indica L.) on La Réunion Island. Additional measurements of Nm, Na, Ma, Ta and photosynthetic capacities were performed on young, fully expanded leaves of 11-year-old mango trees. Leaves of similar gap fractions were taken far from and close to developing fruits. Unlike Nm, both Na and Ta were linearly correlated to gap fraction. Similar relationships were found for all leaves whatever their age and origin, except for Ta, for which we found a significant tree effect. Photosynthetic capacity was nonlinearly correlated to Na, and a unique relationship was obtained for all types of leaves. Photosynthetic acclimation to light was mainly driven by changes in Ma, but allocation of total leaf N between the different photosynthetic functions also played a substantial role in acclimation to the lowest irradiances. Leaves close to developing fruits exhibited a higher photosynthetic capacity than other leaves, but similar Ta. Our data suggest that Ta does not control photosynthetic capacity in mango leaves. We used the data to parameterize a biochemically based model of photosynthesis and an empirical stomatal conductance model, allowing accurate predictions of net photosynthesis of leaves in field-grown mango trees.

  15. [Development of Chemical Exposure Prediction Model for Aerobic Sewage Treatment Plant for Biochemical Wastewaters].

    Science.gov (United States)

    Zhou, Lin-jun; Liu, Ji-ning; Shi, Li-li; Feng, Jie; Xu, Yan-hua

    2016-01-15

    Sewage treatment plant (STP) is a key transfer station for chemicals distributed into different environment compartment, and hence models of exposure prediction play a crucial role in the environmental risk assessment and pollution prevention of chemicals. A mass balance model namely Chinese Sewage treatment plant (C-STP(O)) was developed to predict the fate and exposure of chemicals in a conventional sewage treatment plant. The model was expressed as 9 mixed boxes by compartment of air, water, suspended solids, and settled solids. It was based on the minimum input data required on the notification in new chemicals, such as molecular weight, absorption coefficient, vapor pressure, water solubility, ready or inherent biodegradability. The environment conditions ( Temperature = 283 K, wind speed = 2 m x s(-1)) and the classic STP scenario parameters of China, especially the scenario parameters of water quality and sludge properties were adopted in C-STP( 0) model to reflect Chinese characteristics, these parameters were sewage flow of 35 000 m3 x d(-1), influent BOD5 of 0.15 g x L(-1), influent SS of 0.2 kg x m(-3), effluent SS of 0.02 kg x m(-3), BOD5 removal in aerator of 90% sludge density of 1.6 kg x L(3) and organic carbon content of 0.18-0.19. It adopted the fugacity express for mechanism of linear absorption, first-order degradation, Whitman two resistances. An overall interphase transfer constant which was the sum of surface volatilization and stripping was used to assess the volatilization in aerator. The most important and uncertain input value was the biodegradation rate constant, and determination of which required a tier test strategy from ready or inherent biodegradability data to simulate test in STP. An extrapolated criterion of US EPA to derive biodegradation rate constant using the results of ready and inherent biodegradability was compared with that of EU and was recommended. C-STP ( 0 ) was valid to predict the relative emission of volatilization

  16. Two-Population Dynamics in a Growing Network Model

    CERN Document Server

    Ivanova, Kristinka

    2011-01-01

    We introduce a growing network evolution model with nodal attributes. The model describes the interactions between potentially violent V and non-violent N agents who have different affinities in establishing connections within their own population versus between the populations. The model is able to generate all stable triads observed in real social systems. In the framework of rate equations theory, we employ the mean-field approximation to derive analytical expressions of the degree distribution and the local clustering coefficient for each type of nodes. Analytical derivations agree well with numerical simulation results. The assortativity of the potentially violent network qualitatively resembles the connectivity pattern in terrorist networks that was recently reported. The assortativity of the network driven by aggression shows clearly different behavior than the assortativity of the networks with connections of non-aggressive nature in agreement with recent empirical results of an online social system.

  17. Rumor spreading model considering hesitating mechanism in complex social networks

    Science.gov (United States)

    Xia, Ling-Ling; Jiang, Guo-Ping; Song, Bo; Song, Yu-Rong

    2015-11-01

    The study of rumor spreading has become an important issue on complex social networks. On the basis of prior studies, we propose a modified ​susceptible-exposed-infected-removed (SEIR) model with hesitating mechanism by considering the attractiveness and fuzziness of the content of rumors. We derive mean-field equations to characterize the dynamics of SEIR model on both homogeneous and heterogeneous networks. Then a steady-state analysis is conducted to investigate the spreading threshold and the final rumor size. Simulations on both artificial and real networks show that a decrease of fuzziness can effectively increase the spreading threshold of the SEIR model and reduce the maximum rumor influence. In addition, the spreading threshold is independent of the attractiveness of rumor. Simulation results also show that the speed of rumor spreading obeys the relation "BA network > WS network", whereas the final scale of spreading obeys the opposite relation.

  18. Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest

    Directory of Open Access Journals (Sweden)

    Anton Amann

    2001-01-01

    Full Text Available In animal models, immune activation is often difficult to assess because of the limited availability of specific assays to detect cytokine activities. In human monocytes/macrophages, interferon-γ induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase, which degrades tryptophan via the kynurenine pathway. Therefore, monitoring of neopterin concentrations and of tryptophan degradation can serve to detect the extent of T helper cell 1-type immune activation during cellular immune response in humans. In a porcine model of cardiac arrest, we examined the potential use of neopterin measurements and determination of the tryptophan degradation rate as a means of estimating the extent of immune activation. Urinary neopterin concentrations were measured with high-performance liquid chromatography (HPLC and radioimmunoassay (RIA (BRAHMS Diagnostica, Berlin, Germany. Serum and plasma tryptophan and kynurenine concentrations were also determined using HPLC. Serum and urine neopterin concentrations were not detectable with HPLC in these specimens, whereas RIA gave weakly (presumably false positive results. The mean serum tryptophan concentration was 39.0 Ī 6.2 μmol/l, and the mean kynurenine concentration was 0.85 Ī 0.33 μmol/l. The average kynurenine-per-tryptophan quotient in serum was 21.7Ī 8.4 nmol/μmol, and that in plasma was 20.7Ī 9.5 nmol/μmol (n = 7, which corresponds well to normal values in humans. This study provides preliminary data to support the monitoring of tryptophan degradation but not neopterin concentrations as a potential means of detecting immune activation in a porcine model. The kynurenine-per-tryptophan quotient may serve as a short-term measurement of immune activation and hence permit an estimate of the extent of immune activation.

  19. A biochemically structured model for ethanol fermentation by Kluyveromyces marxianus: A batch fermentation and kinetic study

    DEFF Research Database (Denmark)

    Sansonetti, Sascha; Hobley, Timothy John; Calabrò, V.;

    2011-01-01

    Anaerobic batch fermentations of ricotta cheese whey (i.e. containing lactose) were performed under different operating conditions. Ethanol concentrations of ca. 22gL−1 were found from whey containing ca. 44gL−1 lactose, which corresponded to up to 95% of the theoretical ethanol yield within 15h...... ethanol, lactose, biomass and glycerol during batch fermentation could be described within a ca. 6% deviation, as could the yield coefficients for biomass and ethanol produced on lactose. The model structure confirmed that the thermodynamics considerations on the stoichiometry of the system constrain the...... metabolic coefficients within a physically meaningful range thereby providing valuable and reliable insight into fermentation processes....

  20. BILLBOARD ADVERTISING MODELING BY USING NETWORK COUNT LOCATION PROBLEM

    Directory of Open Access Journals (Sweden)

    Hamid Reza Lashgarian Azad

    2014-06-01

    Full Text Available Many applications in engineering and science rely on the optimization of computationally cost functions. A successful approach in such states is to couple an evolutionary algorithm with a mathematical model which replaces the cost function. By considering of importance of advertising in the business declaration, especially billboard advertising, in this paper we have formulated billboard selection decision making, by using network count location approach which determine informative links in a network, to optimize cost of advertising and billboard visiting. Then, opposition based colonial competitive algorithm, which originally inspired by imperialistic competition, is used to solve mathematical model. Also, we implement proposed model on Sioux Falls city network.