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Sample records for bioaerosols emis par

  1. Data available for the evaluation of the risks related to the bio-aerosols emitted by the domestic wastes storage; Donnees disponibles pour l'evaluation des risques lies aux bioaerosols emis par les installations de stockage des dechets menagers et assimiles

    Energy Technology Data Exchange (ETDEWEB)

    Delery, L.

    2003-12-15

    The dusts production during exploitation in cells is the main source of bio-aerosols emission in storage centers. This report presents data on biological characterization of domestic wastes and the related atmospheric emissions. It concludes that the sanitary risk for the residents is weak and the 200 m area decided by the regulation is sufficient. Meanwhile it is recommended to control the emission levels during particularly meteorological conditions as humid, windy and not very sunny. (A.L.B.)

  2. Integrating EMIS in CIMS

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Enterprise management information system (EMIS) in Manufacturing CIMS Int egrating Platform (MACIP), refers to a computer system that manages the information for running an enterprise. A typ ical EMIS consists of a group of closely connected functions such as production planning, material management, accounting, quality management, etc. The EMIS exc h anges information with the CAD/CAPP system in the design department, and the sho p floor controller (SFC) in the manufacturing department, while the global infor mation system (GIS) of MACIP supplies the mechanism for information sharing with in the enterprise. This paper introduces the EMIS model for a typical manu facturing enterprise, then analyses the interface of the EMIS with the CAD/CAPP system and the SFC. A technical scheme for integrating the EMIS with the GIS is given. This scheme considers the integration of some MRPII systems in the marke t, and adopts advanced industrial standards to ensure its flexibility and reusab ility.

  3. EMI filter design

    CERN Document Server

    Ozenbaugh, Richard Lee

    2011-01-01

    With today's electrical and electronics systems requiring increased levels of performance and reliability, the design of robust EMI filters plays a critical role in EMC compliance. Using a mix of practical methods and theoretical analysis, EMI Filter Design, Third Edition presents both a hands-on and academic approach to the design of EMI filters and the selection of components values. The design approaches covered include matrix methods using table data and the use of Fourier analysis, Laplace transforms, and transfer function realization of LC structures. This edition has been fully revised

  4. EMI-EDGI Operational Level Agreement

    CERN Document Server

    Di Meglio, Alberto

    2012-01-01

    This document is the Operational Level Agreement signed by EMI and EDGI for the contribution of middleware from EDGI into the EMI distribution and the definition of service levels compatible with the existing EMI SLAs

  5. Remote EMI Field Strength Mapping Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA often must deal with the issue of protecting EMI sensitive payloads and instrumentation from damage due to radiated energy. Many of these EMI sensitive...

  6. EMI-resilient amplifier circuits

    CERN Document Server

    van der Horst, Marcel J; Linnenbank, André C

    2014-01-01

    This book enables circuit designers to reduce the errors introduced by the fundamental limitations and electromagnetic interference (EMI) in negative-feedback amplifiers.  The authors describe a systematic design approach for application specific negative-feedback amplifiers, with specified signal-to-error ratio (SER).  This approach enables designers to calculate noise, bandwidth, EMI, and the required bias parameters of the transistors used in  application specific amplifiers in order to meet the SER requirements.   ·         Describes design methods that incorporate electromagnetic interference (EMI) in the design of application specific negative-feedback amplifiers; ·         Provides designers with a structured methodology to avoid the use of trial and error in meeting signal-to-error ratio (SER) requirements; ·         Equips designers to increase EMI immunity of the amplifier itself, thus avoiding filtering at the input, reducing the number of components and avoiding detr...

  7. Concentration and flux of bioaerosol and environmental factors

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The concentration and flux transportation of bioaerosol are analyzed using the data observed in Nanjing in July 1998. Some results are obtained: (i) the concentration and flux transportation of bioaerosol vary periodically with the cycle of the solar radiation and atmospheric turbulent intensity, (ii) The bioaerosol concentration is affected by both the bioaerosol flux transportation and the environmental factors. The bacterial concentration is obviously affected by the solar radiation while the fungi concentration is significantly affected by temperature.

  8. Radiated EMI from power converters

    OpenAIRE

    Arnautovski-Toševa Vesna; Rousset Yanis; Drissi El Khamlichi Khalil; Grčev Leonid

    2005-01-01

    With the continuous increase of switching frequency together with the ongoing trend to higher complexity and functionality, power converters as a part of electronic systems have raised more and more electromagnetic energy pollution to the local system environment. In the same time, stringent demands are imposed on the designers of new circuits that electromagnetic interference (EMI) has to be suppressed at its source before it is allowed to propagate into other circuits and systems. In this p...

  9. EMI kaob kaubamärgina

    Index Scriptorium Estoniae

    2002-01-01

    Ümberstruktueerimise käigus lõpetab suuruselt maailma kolmas muusikafirma EMI oma nime kasutamise kaubamärgina ega trüki seda enam plaadiümbristele. Plaadid hakkavad ilmuma märkide Capitol ja Virgin all. EMI on lühend nimetusest Electric and Music Industries, see jääb kasutusele firmasiseselt

  10. Workload management in the EMI project

    Science.gov (United States)

    Andreetto, Paolo; Bertocco, Sara; Capannini, Fabio; Cecchi, Marco; Dorigo, Alvise; Frizziero, Eric; Gianelle, Alessio; Kretsis, Aristotelis; Mezzadri, Massimo; Monforte, Salvatore; Prelz, Francesco; Rebatto, David; Sgaravatto, Massimo; Zangrando, Luigi

    2012-12-01

    The EU-funded project EMI, now at its second year, aims at providing a unified, high quality middleware distribution for e-Science communities. Several aspects about workload management over diverse distributed computing environments are being challenged by the EMI roadmap: enabling seamless access to both HTC and HPC computing services, implementing a commonly agreed framework for the execution of parallel computations and supporting interoperability models between Grids and Clouds. Besides, a rigourous requirements collection process, involving the WLCG and various NGIs across Europe, assures that the EMI stack is always committed to serving actual needs. With this background, the gLite Workload Management System (WMS), the meta-scheduler service delivered by EMI, is augmenting its functionality and scheduling models according to the aforementioned project roadmap and the numerous requirements collected over the first project year. This paper is about present and future work of the EMI WMS, reporting on design changes, implementation choices and longterm vision.

  11. Morphological classification of bioaerosols from composting using scanning electron microscopy

    OpenAIRE

    Tamer Vestlund, Asli; Al-Ashaab, R.; Tyrrel, Sean F.; Longhurst, Philip J.; Pollard, Simon J. T.; Drew, Gillian H

    2014-01-01

    This research classifies the physical morphology (form and structure) of bioaerosols emitted from open windrow composting. Aggregation state, shape and size of the particles captured are reported alongside the implications for bioaerosol dispersal after release. Bioaerosol sampling took place at a composting facility using personal air filter samplers. Samples were analysed using scanning electron microscopy. Particles were released mainly as small (1 μm) single cells, with aggregates occurri...

  12. Radiated EMI from power converters

    Directory of Open Access Journals (Sweden)

    Arnautovski-Toševa Vesna

    2005-01-01

    Full Text Available With the continuous increase of switching frequency together with the ongoing trend to higher complexity and functionality, power converters as a part of electronic systems have raised more and more electromagnetic energy pollution to the local system environment. In the same time, stringent demands are imposed on the designers of new circuits that electromagnetic interference (EMI has to be suppressed at its source before it is allowed to propagate into other circuits and systems. In this paper, the authors present a full-wave numerical method for calculation and simulation of electromagnetic field radiated by power converter circuitry. The main objective is to analyze the layout geometry in order to obtain competitive PCB layout that will enable suitably attenuated level of the radiated electric field to safe level. By this it would be possible to ensure reliable operation of the sensitive electronic components in the proximity.

  13. Conducted EMI Evaluation and Reduction in a Forward Switching Converter

    Directory of Open Access Journals (Sweden)

    Mohammad Rouhollah Yazdani

    2012-04-01

    Full Text Available In switching power converters, electromagnetic interference (EMI is produced due to the fast changes of the voltage and current. Among switching topologies used in low and medium powers, forward converter is vastly employed which needs resetting transformer core. In this paper, a forward converter with reset winding is modeled to predict conducted EMI. To evaluate the EMI model, EMI measurement results are presented. To select an optimum reset scheme from EMI viewpoint, three reset techniques are compared using experimental results. After selecting the proper reset scheme, two EMI mitigation methods are proposed and the practical EMI reduction is presented.

  14. Conducted EMI Evaluation and Reduction in a Forward Switching Converter

    OpenAIRE

    Mohammad Rouhollah Yazdani; Nahid Amini Filabadi

    2012-01-01

    In switching power converters, electromagnetic interference (EMI) is produced due to the fast changes of the voltage and current. Among switching topologies used in low and medium powers, forward converter is vastly employed which needs resetting transformer core. In this paper, a forward converter with reset winding is modeled to predict conducted EMI. To evaluate the EMI model, EMI measurement results are presented. To select an optimum reset scheme from EMI viewpoint, three reset technique...

  15. EMI Shields made from intercalated graphite composites

    Science.gov (United States)

    Gaier, James R.; Terry, Jennifer

    1995-01-01

    Electromagnetic interference (EMI) shielding typically makes up about twenty percent of the mass of a spacecraft power system. Graphite fiber/polymer composites have significantly lower densities and higher strengths than aluminum, the present material of choice for EMI shields, but they lack the electrical conductivity that enables acceptable shielding effectiveness. Bromine intercalated pitch-based graphite/epoxy composites have conductivities fifty times higher than conventional structural graphite fibers. Calculations are presented which indicate that EMI shields made from such composites can have sufficient shielding at less than 20% of the mass of conventional aluminum shields. EMI shields provide many functions other than EMI shielding including physical protection, thermal management, and shielding from ionizing radiation. Intercalated graphite composites perform well in these areas also. Mechanically, they have much higher specific strength and modulus than aluminum. They also have shorter half thicknesses for x-rays and gamma radiation than aluminum. Thermally, they distribute infra-red radiation by absorbing and re-radiating it rather than concentrating it by reflection as aluminum does. The prospects for intercalated graphite fiber/polymer composites for EMI shielding are encouraging.

  16. EMIS: Enrichment Management Information System

    International Nuclear Information System (INIS)

    The objective of the effort was the development of a calculational tool which would permit DOE to make realistic projections of the separative work demands of its customers as an aid in planning for the future operation of the enrichment facilities. The calculational methods were to recognize the flexibility in scheduling, etc., available to DOE customers under their enrichment contreacts as well as the ability to pool separative work withdrawn under two or more contracts. It was also to be designed to permit the user to add new customers or delete existing contracts as well as to allow variation of the estimated start-up dates for those reactors currently under construction. The output of the model was to display projections of separative work demand as SWU and in triplet form for several categories of reactors. These included, in addition to the total demand on the enrichment complex, separate totals for domestic and foreign customers, for reactors with Requirements and Adjustable Fixed Commitment contracts and for reactors in operation, under construction and projected new reactors designated by the user. The foundations upon which the system is based are described in this report. This includes a discussion of the available alternatives for customer management of separative work and the assumptions and guidelines established for development of the model. The report also contains a description of the computational procedures used in the model, and a description of the EMIS system itself, which also serves as a users' manual for the code. Finally, samples demonstrating the use of the system and indicating the form of the input and output are included

  17. Study on Bioagents or Bioaerosols standoff detection by lidar

    Directory of Open Access Journals (Sweden)

    Yang Hui

    2016-01-01

    Full Text Available Scattering, fluorescence and polarization are the important data source for bioagent or bioaerosol time-space observation and identification. This paper stated and discussed the theory and data inversion principles for Mie scattering, laser induced fluorescence and polarization sensing Lidar. The sensing and data inversion results for bioagent/bioaerosol extinction coefficient, horizontal linear depolarization ratio were also demonstrated. The signal and SNR simulation of fluorescence lidar were also demonstrated. The sensing results revealed that the three kinds of detecting technology approaches are reasonable and potential for bioagent/bioaerosol characterization and recognition.

  18. EMI filter techniques in power electronic converters

    Directory of Open Access Journals (Sweden)

    Fredy Edimer Hoyos Velasco

    2012-04-01

    Full Text Available This paper presents the results of EMI reduction techniques applied to power electronic converters. The techniques applied included shielding control and power signals, separating power system references regarding reference for instrumentation and measurement signals, implementing analog filters and configuring an appropriate switch trigger system for electronic power to decrease shifting EMI emissions to the maximum. This paper presents the results before and after applying the techniques to reduce interference. The results were also veryfied by using two real time control strategies rapid control prototyping (RCP.

  19. EMI/RFI ampersand Digital I ampersand C upgrades - workshop

    International Nuclear Information System (INIS)

    This collection of figures from the EPRI EMI/RFI Workshop for Nuclear Power Plants, held in Baltimore, MD, September 10-11, 1992 describes EMI/RFI issues, the basis for these issues, immediate EMI/RFI research and development actions, and future EMI/RFI research and development projects. The EMI/RFI issues which are addressed include the unpredictability of EMI/RFI effects on the digital safety I ampersand C system, the need for models to prove sufficient EMI/RFI immunity for digital safety systems inside a nuclear power plant, differences between responses of digital and analog I ampersand C systems, variations in standards for addressing problems, and the problem that licensing of digital safety systems for nuclear power plants requires proof of EMI/RFI immunity

  20. Simple optimization method for EMI mesh pattern design

    Science.gov (United States)

    Alpman, Mehmet Erhan; Senger, Tolga

    2014-05-01

    Metallic mesh coatings are used on visible and infrared windows and domes widely to provide shielding from EMI (Electromagnetic Interference). In this paper, different EMI mesh geometries are compared with each other regarding various performance parameters. But to decide the best fitting EMI mesh geometry to particular optic system is a little bit complicated issue. Therefore, we try to find a simple optimization methodology to decide best EMI mesh geometry design that fits our particular high performance ISR (Intelligence, Surveillance and Reconnaissance) systems.

  1. Bioaerosol sampling: sampling mechanisms, bioefficiency and field studies.

    Science.gov (United States)

    Haig, C W; Mackay, W G; Walker, J T; Williams, C

    2016-07-01

    Investigations into the suspected airborne transmission of pathogens in healthcare environments have posed a challenge to researchers for more than a century. With each pathogen demonstrating a unique response to environmental conditions and the mechanical stresses it experiences, the choice of sampling device is not obvious. Our aim was to review bioaerosol sampling, sampling equipment, and methodology. A comprehensive literature search was performed, using electronic databases to retrieve English language papers on bioaerosol sampling. The review describes the mechanisms of popular bioaerosol sampling devices such as impingers, cyclones, impactors, and filters, explaining both their strengths and weaknesses, and the consequences for microbial bioefficiency. Numerous successful studies are described that point to best practice in bioaerosol sampling, from the use of small personal samplers to monitor workers' pathogen exposure through to large static samplers collecting airborne microbes in various healthcare settings. Of primary importance is the requirement that studies should commence by determining the bioefficiency of the chosen sampler and the pathogen under investigation within laboratory conditions. From such foundations, sampling for bioaerosol material in the complexity of the field holds greater certainty of successful capture of low-concentration airborne pathogens. From the laboratory to use in the field, this review enables the investigator to make informed decisions about the choice of bioaerosol sampler and its application. PMID:27112048

  2. Effects of bioaerosol polluted outdoor air on airways of residents: a cross sectional study

    OpenAIRE

    Herr, C; Zur Nieden, A.; Jankofsky, M; Stilianakis, N.; Boedeker, R; Eikmann, T

    2003-01-01

    Background: Bioaerosol pollution of workplace and home environments mainly affects airways and mucous membranes. The effect of environmental outdoor residential bioaerosol pollution, for example, livestock holdings, farming, and waste disposal plants, is unclear.

  3. Vehicle drive module having improved EMI shielding

    Science.gov (United States)

    Beihoff, Bruce C.; Kehl, Dennis L.; Gettelfinger, Lee A.; Kaishian, Steven C.; Phillips, Mark G.; Radosevich, Lawrence D.

    2006-11-28

    EMI shielding in an electric vehicle drive is provided for power electronics circuits and the like via a direct-mount reference plane support and shielding structure. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support forms a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  4. Smart EMI monitoring of thin composite structures

    OpenAIRE

    Selva, Pierre; Cherrier, Olivier; Pommier-Budinger, Valérie; Lachaud, Frédéric; MORLIER, Joseph

    2011-01-01

    This paper presents a structural health monitoring (SHM) method for in-situ damage detection and localization in carbon fibre reinforced plates (CFRP). The detection is achieved using the electromechanical impedance (EMI) technique employing piezoelectric transducers as high-frequency modal sensors. Numerical simulations based on the finite element method are carried out so as to simulate more than a hundred damage scenarios. Damage metrics are then used to quantify and detect changes betw...

  5. Foamed Nanocomposites for EMI Shielding Applications

    OpenAIRE

    Molenberg, Isabel; Huynen, Isabelle; Baudouin, Anne-Christine; Bailly, Christian; Thomassin, Jean-Michel; Detrembleur, Christophe

    2010-01-01

    Throughout this chapter, we have seen that foamed polymer/CNTs nanocomposites make very good EMI shielding materials. They exhibit a high conductivity and a relatively low dielectric constant, leading to a high Shielding Effectiveness and a relatively low Reflectivity, although a compromise in CNT content must be found between a high SE and a low R. This was confirmed by measurement results and rheological measurements but also using a simple electrical equivalent model.

  6. Engineering lecturers’ views on CLIL and EMI

    OpenAIRE

    Aguilar Pérez, Marta

    2015-01-01

    The present study aims to shed some light on how engineering lecturers teaching in English at a Spanish university view their work (teaching goals) within the current European internationalisation trend of offering courses and master programmes in English. A questionnaire where content and language integrated learning (CLIL) and English-medium instruction (EMI) were differentiated and with questions on their self-attributed duties, training preferences, assessment and internationalisation iss...

  7. Seasonal Distribution of Bioaerosols in the Coastal Region of Qingdao

    Institute of Scientific and Technical Information of China (English)

    QI Jianhua; SHAO Qian; XU Wenbing; GAO Dongmei; JIN Chuan

    2014-01-01

    Bioaerosols were collected by using a six-stage bioaerosols sampler from September 2007 to August 2008 in the coastal region of Qingdao, China. The terrestrial and marine microbes (including bacteria and fungi) were analyzed in order to understand the distribution features of bioaerosols. The results show that the average monthly concentrations of terrestrial bacteria, marine bacte-ria, terrestrial fungi and marine fungi are in the ranges of 80-615 CFU m-3, 91-468 CFU m-3, 76-647 CFU m-3 and 231-1959 CFU m-3, respectively. The concentrations of terrestrial bacteria, marine bacteria, terrestrial fungi, marine fungi and total microbes are the highest in each microbial category during fall, high in spring, and the lowest in the summer and winter. The bacterial particles are coarse in spring, autumn and winter. The sizes of fungal particle present the log-normal distribution in all the seasons.

  8. LIF bio-aerosol threat triggers: then and now

    Science.gov (United States)

    DeFreez, Richard

    2009-09-01

    Bio-aerosol terrorist attacks have been carried out against civilians in the United States and elsewhere. Unfortunately, recurrence appears inevitable. A fast, reliable, and inexpensive bioaerosol threat detection trigger can be an important tool for detect-to-protect and detect-to-treat countermeasure scenarios. Bio-aerosol threat detection triggers employing light, historically laser light but recently LED light, for induced native- or auto-fluorescence (LIF) have been developed for well over a decade without a generally accepted solution being found. This paper presents a brief history of LIF triggers and reviews many vendor efforts, past and current. Various technical approaches and design considerations are discussed. Triggers from ICx technology, currently available or in development, are also discussed.

  9. Design and performance of an EMI filter to reduce conducted EMI in an isolated full bridge buck converter power supply

    Institute of Scientific and Technical Information of China (English)

    Abdolreza Esmaeli; SUN Li; ZHAO Ke; JIANG Bao-jun

    2005-01-01

    EMI Filter Design and Performance for isolated full bridge buck converter is developed in this paper.In order to design a high performance EMI filter, many issues need to be considered beforehand. Some important issues including accurate model of converter components, parasitic elements, its effect on EMI noise and impedance mismatch are included in this paper. A numerical prediction of EMI/EMC has the potential to evaluate EMI performances at the design stage and before prototyping. It can also help reduce the post-prototype EMC cost by minimizing late redesign and modifications of a design implementation. Saber simulator is used to analyze the EMI noises and EMI filter's performance. Conducted EMI noise measurement and EMI filter design of isolated full bridge buck converter has been achieved while successfully satisfying the FCC class B limits in the frequency range from 150 kHz to 30 MHz. Simulation results are compared with experimental data and the effectiveness of the EMI simulation approach is demonstrated.

  10. Precise methods for conducted EMI modeling,analysis,and prediction

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Focusing on the state-of-the-art conducted EMI prediction, this paper presents a noise source lumped circuit modeling and identification method, an EMI modeling method based on multiple slope approximation of switching transitions, and dou-ble Fourier integral method modeling PWM conversion units to achieve an accurate modeling of EMI noise source. Meanwhile, a new sensitivity analysis method, a general coupling model for steel ground loops, and a partial element equivalent circuit method are proposed to identify and characterize conducted EMI coupling paths. The EMI noise and propagation modeling provide an accurate prediction of conducted EMI in the entire frequency range (0―10 MHz) with good practicability and generality. Finally a new measurement approach is presented to identify the surface current of large dimensional metal shell. The proposed analytical modeling methodology is verified by experimental results.

  11. Children recognize emotions of EmI companion robot

    OpenAIRE

    Saint-Aimé, Sébastien; Le Pevedic, Brigitte; Duhaut, Dominique

    2011-01-01

    This article presents the evaluation of the emotional expressiveness of EmI companion robot in the EmotiRob project. We describe iGrace emotional computational model of emotion to generate an emotional response based on the speech of the interlocutor, the mechanical design and implementation of EmI, and experimentation to evaluate the expressiveness of EmI with 52 school children aged 7 to 9 years.

  12. Improving EMI Attenuation in Frequency Modulated Power Converters

    OpenAIRE

    Stepins, D.

    2009-01-01

    The effect of frequency modulation on a power switching converter electromagnetic interference (EMI) attenuation is examined in this paper. A method known as “modified sawtooth” is applied for EMI attenuation in a boost converter and it is optimized in such a way to reduce EMI more effectively. The method is also verified experimentally by the use of a low power boost converter controlled via an arbitrary waveform generator. EMI attenuation up to 15 dB is achieved after using modified sawtoot...

  13. Conducted EMI Suppression in Plasma Cutting Power Supply

    Institute of Scientific and Technical Information of China (English)

    Abdolreza Esmaeli; Sun Li; Zhao Ke

    2005-01-01

    A systematic approach to the design of the conducted electromagnetic interference (EMI) filter of high-density plasma cutting power supply has been developed. Converter components have been accurately modeled, with parasitic elements extracted to reveal their impacts on the EMI noises. Circuit simulations have been used to analyze and minimize the EMI noises.Conducted EMI noise measurement and filter design of this power supply have been achieved which successfully satisfy the FCC class B limits in the frequency range from 150 kHz to 30 MHz.The analyses and experimental results show that the designed filter guarantees that the required attenuation will be achieved.

  14. Zzaap! taming ESD, FRI, and EMI

    CERN Document Server

    Corp, M Bruce

    1990-01-01

    A ""zzap""! is the mortal enemy of today's sophisticated electronics designs. A ""zzaap!"" can cause a circuit to ""lock up"" or ""hang"" -delete bits form a data stream or mysteriously insert bits that aren't supposed to be there or, worst of all, cause the sudden failure of critical integrated circuits. M. Bruce Corp takes you inside the often mysterious world of electrostatic discharge (ESD), radio frequency interference (RFI, and electromagnetic interference (EMI) to show how these can cause a bewildering array of transient problems or catastrophic failures.

  15. Urban enhancement of PM10 bioaerosol tracers relative to background locations in the Midwestern United States

    Science.gov (United States)

    Rathnayake, Chathurika M.; Metwali, Nervana; Baker, Zach; Jayarathne, Thilina; Kostle, Pamela A.; Thorne, Peter S.; O'Shaughnessy, Patrick T.; Stone, Elizabeth A.

    2016-05-01

    Bioaerosols are well-known immune-active particles that exacerbate respiratory diseases. Human exposures to bioaerosols and their resultant health impacts depend on their ambient concentrations, seasonal and spatial variation, and copollutants, which are not yet widely characterized. In this study, chemical and biological tracers of bioaerosols were quantified in respirable particulate matter (PM10) collected at three urban and three background sites in the Midwestern United States across four seasons in 2012. Endotoxins from Gram-negative bacteria (and a few Gram-positive bacteria), water-soluble proteins, and tracers for fungal spores (fungal glucans, arabitol, and mannitol) were ubiquitous and showed significant seasonal variation and dependence on temperature. Fungal spores were elevated in spring and peaked in summer, following the seasonal growing cycle, while endotoxins peaked in autumn during the row crop harvesting season. Paired comparisons of bioaerosols in urban and background sites revealed significant urban enhancements in PM10, fungal glucans, endotoxins, and water-soluble proteins relative to background locations, such that urban populations have a greater outdoor exposure to bioaerosols. These bioaerosols contribute, in part, to the urban excesses in PM10. Higher bioaerosol mass fractions in urban areas relative to background sites indicate that urban areas serve as a source of bioaerosols. Similar urban enhancements in water-soluble calcium and its correlation with bioaerosol tracers point toward windblown soil as an important source of bioaerosols in urban areas.

  16. Evaluation of EMP/EMI requirements versus corrosion prevention methods

    Science.gov (United States)

    Gooch, Jan W.; Hawley, Paul M.; Daher, John K.; Lagesse, Daniel M.

    1992-10-01

    Final report covers the application of conductive sealants on an E-3 aircraft for nine months and evaluating the Electromagnetic Pulse (EMP) / Electromagnetic Interference (EMI) Requirements and corrosion damage. Also, additional testing was performed on three conductive sealants for corrosion protection via the salt fog chambers. Using conductive sealants will meet both EMP/EMI and corrosion requirements.

  17. Conducted EMI in Inverters with SiC Transistors

    NARCIS (Netherlands)

    Gong, X.

    2013-01-01

    Conducted EMI in Inverters with SiC Transistors Electromagnetic Interference (EMI) is the main side effect accompanied with the fast voltage and current switching transients in power electronics applications. Compliance of the Electromagnetic Compatibility (EMC) standard is prescribed for any power

  18. Robustness of a TETRA base station receiver against intentional EMI

    NARCIS (Netherlands)

    Beek, van de Stefan; Leferink, Frank

    2015-01-01

    Terrestrial trunked radio (TETRA) is a digital radio standard that was developed to meet the needs of professional mobile radio systems. TETRA is vulnerable to intentional electromagnetic interference (EMI) because of the wireless link. The EMI can easily be front door coupled to the base station vi

  19. Bioaerosol sampling for the detection of aerosolized influenza virus

    Science.gov (United States)

    Blachere, Francoise M.; Lindsley, William G.; Slaven, James E.; Green, Brett J.; Anderson, Stacey E.; Chen, Bean T.; Beezhold, Don H.

    2007-01-01

    Background Influenza virus was used to characterize the efficacy of a cyclone‐based, two‐stage personal bioaerosol sampler for the collection and size fractionation of aerosolized viral particles. Methods A Collison single‐jet nebulizer was used to aerosolize the attenuated FluMist® vaccine into a calm‐air settling chamber. Viral particles were captured with bioaerosol samplers that utilize 2 microcentrifuge tubes to collect airborne particulates. The first tube (T1) collects particles greater than 1.8 μm in diameter, while the second tube (T2) collects particles between 1.0 and 1.8 μm, and the back‐up filter (F) collects submicron particles. Following aerosolization, quantitative PCR was used to detect and quantify H1N1 and H3N2 influenza strains. Results Based on qPCR results, we demonstrate that aerosolized viral particles were efficiently collected and separated according to aerodynamic size using the two‐stage bioaerosol sampler. Most viral particles were collected in T2 (1‐1.8 μm) and on the back‐up filter (< 1 μm) of the bioaerosol sampler. Furthermore, we found that the detection of viral particles with the two‐stage sampler was directly proportional to the collection time. Consequently, viral particle counts were significantly greater at 40 minutes in comparison to 5, 10 and 20 minute aerosol collection points. Conclusions Due to a lack of empirical data, aerosol transmission of influenza is often questioned. Using FluMist®, we demonstrated that a newly developed bioaerosol sampler is able to recover and size fractionate aerosolized viral particles. This sampler should be an important tool for studying viral transmission in clinical settings and may significantly contribute towards understanding the modes of influenza virus transmission. PMID:19453416

  20. CHARACTERIZATIONS AND RELATIONSHIPS BETWEEN OUTDOOR AND INDOOR BIOAEROSOLS IN AN OFFICE BUILDING

    Institute of Scientific and Technical Information of China (English)

    Hong Zhu; Patrick Phelan; Tianhua Duan; Gregory Raupp; H. J. S. Fernando

    2003-01-01

    Characterizations and relationships between indoor and outdoor bioaerosols were examined in an occupied office building, equipped with an air conditioning (HVAC) system, in Tempe, Arizona, USA. A two-stage microbial air sampler was used to collect bioaerosols both inside and outside the office at fixed locations in space and at regular time intervals from August to December, 2000. Simultaneous measurements of bioaerosol, temperature, relative humidity,light intensity and wind speed were performed to explore the effects of environmental factors on bioaerosol levels.Twenty species of airborne bacteria and four genera of airborne fungi were found in our samples. The particle sizes of most outdoor and indoor bioaerosols were larger than 8.0 μm. According to the measurements of sampling days, the concentrations of outdoor bioaerosols were highest in the morning, but declined in the afternoon and reached the lowest point in the evening. The concentration peak of indoor bioaerosol (especially at the lower level) occurred in the evening,suggesting that the concentration of indoor bioaerosols follows that of outdoors, but with a time delay due to the lag associated with indoor-outdoor air exchange. With regard to the effects of four environmental factors - temperature, relative humidity, light intensity, and wind speed, the relative humidity had the most pronounced influence on the outdoor bioaerosol concentrations with the number of bacteria and fungi increasing sharply on a day of high relative humidity in the desert area.

  1. DNA-based nanoparticle composite materials for EMI shielding

    Science.gov (United States)

    Zang, De Yu; Grote, James

    2012-03-01

    Composite materials, such as polymer-matrix containing conductive fillers, are very attractive for shielding electromagnetic interference (EMI) due to their high shielding efficiency and seamlessness, processability, flexibility, light-weight and low-cost. Here, we report a development of novel, DNA-based EMI-shielding materials (DESM), consisting of DNA and metal nanoparticles. It has been shown that a thin DESM layer (typically ~30 - 50 μm) could block EMI radiations up to 60 dB effectively over an RF frequency range from KHz to tens GHz, exhibiting excellent EMI shielding efficiency. A wide selection of metal nanoparticle fillers for DESM has been tested for their performance in EMI shielding efficiency. Among them, silver and carbon-based nanoparticles have demonstrated the best performance and were selected for further investigation. The silver-doped DESM films could be also non-conductive while their EMI shielding efficiency is still well-preserved. The nonconductive DESM could have a great potential in the microelectronics industries for EMI shielding on electronic devices and circuit boards.

  2. Mielenterveyskuntoutujien ruokailutottumusten ‎kartoitus EMY ry:ssä

    OpenAIRE

    Luukkonen, Anni; Isokangas, Anna-Liisa

    2010-01-01

    Opinnäytetyömme tarkoituksena on kartoittaa mielenterveyskuntoutujien näkemyksiä terveellisestä ‎ruoasta, heidän omia ruokailutottumuksiaan ja näkemyksiä talkooruokailusta Espoon ‎mielenterveysyhdistys ry:ssä (EMY ry). EMY ry tekee töitä mielenterveyden edistämiseksi Espoon ‎seudulla. EMY ry on esittänyt Laurea-ammattikorkeakoulun hankefoorumipäivillä tutkimusideansa ‎talkooruokailunsa kehittämisestä. Toteutimme opinnäytetyön osana Työn rajalla- hanketta, joka ‎on osa Laurea-ammattikorkeakoul...

  3. Chamber catalogues of optical and fluorescent signatures distinguish bioaerosol classes

    Science.gov (United States)

    Hernandez, Mark; Perring, Anne E.; McCabe, Kevin; Kok, Greg; Granger, Gary; Baumgardner, Darrel

    2016-07-01

    Rapid bioaerosol characterization has immediate applications in the military, environmental and public health sectors. Recent technological advances have facilitated single-particle detection of fluorescent aerosol in near real time; this leverages controlled ultraviolet exposures with single or multiple wavelengths, followed by the characterization of associated fluorescence. This type of ultraviolet induced fluorescence has been used to detect airborne microorganisms and their fragments in laboratory studies, and it has been extended to field studies that implicate bioaerosol to compose a substantial fraction of supermicron atmospheric particles. To enhance the information yield that new-generation fluorescence instruments can provide, we report the compilation of a referential aerobiological catalogue including more than 50 pure cultures of common airborne bacteria, fungi and pollens, recovered at water activity equilibrium in a mesoscale chamber (1 m3). This catalogue juxtaposes intrinsic optical properties and select bandwidths of fluorescence emissions, which manifest to clearly distinguish between major classes of airborne microbes and pollens.

  4. Gaseous and bioaerosol emissions from municipal wastewater treatment plants.

    Science.gov (United States)

    Seetha, N; Bhargava, Renu; Gurjar, B R

    2013-10-01

    Wastewater treatment plants (WWTPs) are identified as potential emission sources of greenhouse gases (GHGs) and bioaerosols. This paper reviews and analyse the potential sources of GHGs and bioaerosols from different unit operations and processes of WWTPs. Aeration tanks of activated sludge process (ASP) are found to be the most important sources of GHGs as well as bioaerosol emissions. Nitrification and denitrification processes are found to be important sources of nitrous oxide (N2O) emissions. To minimize the N2O emissions from WWTPs, dissolved oxygen (DO) concentration should be kept greater than 2 mg/L in nitrification process, whereas purely anoxic condition (0 mg/L DO) is required in denitrification process. Diffused aeration emits fewer microbes into the air than surface aerators. It is observed that fixed-film processes emit microbes by two orders of magnitude less than aeration tanks. The various WWTPs discussed in this study used different methods of treatment sample collection and species of microorganisms studied. It is realised that the standardisation of the microorganisms to be analysed and methods of sample collection needs to be done. It is also found that from the microbiological point of view, there is no clean air in the vicinity of a WWTP. PMID:25906597

  5. Intercalated graphite fiber composites as EMI shields in aerospace structures

    Science.gov (United States)

    Gaier, James R.

    1992-01-01

    The requirements for electromagnetic interference (EMI) shielding in aerospace structures are more complicated than those for ground structures because of their weight limitations. As a result, the best EMI shielding materials must combine low density, high strength, and high elastic modulus with high shielding ability. EMI shielding characteristics were calculated for shields formed from pristine and intercalated graphite fiber/epoxy composites and compare to preliminary experimental results for these materials and to the characteristics of shields made from aluminum. Calculations indicate that effective EMI shields could be fabricated from intercalated graphite composites which would have less than 12 percent of the mass of conventional aluminum shields, based on mechanical properties and shielding characteristics alone.

  6. Systematic Design of EMI-Resilient Negative-Feedback Amplifiers

    OpenAIRE

    van der Horst, M. J.

    2012-01-01

    The information transfer capacity of negative-feedback amplifiers, and electronic circuits in general, is limited by three fundamental limitations being noise, bandwidth, and signal power. Electromagnetic Interference (EMI) is not a fundamental limitation, but it also hampers the information transfer. EMI may have such detrimental effects that malfunctioning of the electronic circuit occurs. This may result in loss of information, or worse, possibly dangerous situations. That is a reason why ...

  7. Integrated EMI/Thermal Design for Switching Power Supplies

    OpenAIRE

    Zhang, Wei

    1998-01-01

    This work presents the modeling and analysis of EMI and thermal performance for switch power supply by using the CAD tools. The methodology and design guidelines are developed. By using a boost PFC circuit as an example, an equivalent circuit model is built for EMI noise prediction and analysis. The parasitic elements of circuit layout and components are extracted analytically or by using CAD tools. Based on the model, circuit layout and magnetic component design are modified to minimize...

  8. Following the Biochemical and Morphological Changes of Bacillus atrophaeus during Sporulation using Bioaerosol Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Tobias, H J; Pitesky, M E; Fergenson, D P; Horn, J; Frank, M; Gard, E E

    2006-05-03

    The overall objective of this report is to develop a real-time single-particle mass spectrometry technique called Bio-Aerosol Mass Spectrometry (BAMS) in order to efficiently screen and identify bioaerosols and single cells of national security and public health concern.

  9. Epiphytic cryptogams as a source of bioaerosols and trace gases

    Science.gov (United States)

    Ruckteschler, Nina; Hrabe de Angelis, Isabella; Zartman, Charles E.; Araùjo, Alessandro; Pöschl, Ulrich; Manzi, Antonio O.; Andreae, Meinrat O.; Pöhlker, Christopher; Weber, Bettina

    2016-04-01

    Cryptogamic covers comprise (cyano-)bacteria, algae, lichens, bryophytes, fungi, and archaea in varying proportions. These organisms do not form flowers, but reproduce by spores or cell cleavage with these reproductive units being dispersed via the atmosphere. As so-called poikilohydric organisms they are unable to regulate their water content, and their physiological activity pattern mainly follows the external water conditions. We hypothesize, that both spore dispersal and the release of trace gases are governed by the moisture patterns of these organisms and thus they could have a greater impact on the atmosphere than previously thought. In order to test this hypothesis, we initiated experiments at the study site Amazonian Tall Tower Observatory (ATTO) in September 2014. We installed microclimate sensors in epiphytic cryptogams at four different heights of a tree to monitor the activity patterns of these organisms. Self-developed moisture probes are used to analyze the water status of the organisms accompanied by light and temperature sensors. The continuously logged data are linked to ongoing measurements of trace gases and particulate bioaerosols to analyze these for the relevance of cryptogams. Here, we are particularly interested in diurnal cycles of coarse mode particles and the atmospheric abundance of fine potassium-rich particles from a currently unknown biogenic source. Based upon the results of this field study we also investigate the bioaerosol and trace gas release patterns of cryptogamic covers under controlled conditions. With this combined approach of field and laboratory experiments we aim to disclose the role of cryptogamic covers in bioaerosol and trace gas release patterns in the Amazonian rainforest.

  10. Evaluation of the potential for bioaerosols from land applied biosolids

    Energy Technology Data Exchange (ETDEWEB)

    Tanner, Benjamin; Brooks, John; Josephseon, Karen; Gerba, Charles; Pepper, Ian

    2003-07-01

    The overall objective of this study was to quantitatively and qualitatively document the potential hazards of biological aerosols derived from land applied biosolids, and ultimately develop risk assessment models and land-management strategies for safe, effective use of biosolids. The specific objectives were: i) Quantify bacterial and viral microorganisms emitted as bioaerosols from point sources of biosolids, and area (land-applied) sources of biosolids; ii) Develop risk assessment models based on a) hazard identification, b) dose response, c) exposure assessment; d) risk characterization. Research has consisted of laboratory studies at the University of Arizona and field studies at several regional U.S. locations. Bioaerosol samples have been collected via ''Impingement'' using SKC biosamplers. The biologicals monitored for included: i) viruses: enteroviruses, calciviruses; ii) phage e.g, MS2; iii) E. coil; iv) Salmonella; v) total coliforms; vi) Clostridium perfringens; vii) Aspergillus spp.; viii) Endotoxin. Air samples were collected at discrete distances torn both biosolid piles (point sources), or land applied biosolids (area sources). (author)

  11. Development of a New Sampling Medium for Bioaerosols

    Institute of Scientific and Technical Information of China (English)

    JUN-HUI ZHAI; MEI-LING CHEN; XIU-ZHI XU; ZHEN-HAI SUN; YU ZHOU; FENG-XIANG CHE; RUI-FU YANG

    2005-01-01

    Objective To develop a new sampling medium for detecting of bioaerosols. Methods The sampling media were tested by using Escherichia coli, Staphylococcus aureus and Serratia marcescens under static and active conditions, preliminary applications were performed using AGI-10 and high volume sampler. Results The average recovery rates were raised to 24.7%, 58.2%, 40.5%, 44.1%, 20.5%, and 15.4%, respectively in six consecutive experiments under static condition for 60 min at room temperature. Four kinds of sampling media were singled out after static experiments, which were referred to as "samplutions" PD1, PX2, TD1, and TX2, respectively. Under the active condition, the protective efficacy of PD1, PX2, TD1, and TX2 was 226% (153/47), 553% (111/17), 150% (120/48), and 268% (419/114), respectively. Conclusion The samplutions have some effects on the subsequent nucleic acid detection, which could be avoided by employing standard nucleic acid extraction procedure. The newly developed samplution can be applied to the detection of bioaerosols.

  12. Education Management Information Systems (EMIS) in Latin America and the Caribbean: Lessons and Challenges

    OpenAIRE

    Thomas Cassidy

    2006-01-01

    This paper provides a review of the status of Education Management Information Systems (EMIS) in Latin American and the Caribbean. It includes a history of EMIS development efforts in the region; an outline of practical lessons learned from earlier EMIS development efforts; the identification of current and emerging challenges for developing EMIS; and the identification of promising examples of the use of better data and information to inform education policy and planning. The study was prepa...

  13. Efficiency of Airborne Sample Analysis Platform (ASAP Bioaerosol Sampler for Pathogen Detection

    Directory of Open Access Journals (Sweden)

    Anurag eSharma

    2015-05-01

    Full Text Available The threat of bioterrorism and pandemics has highlighted the urgency for rapid and reliable bioaerosol detection in different environments. Safeguarding against such threats requires continuous sampling of the ambient air for pathogen detection. In this study we investigated the efficacy of the Airborne Sample Analysis Platform (ASAP 2800 bioaerosol sampler to collect representative samples of air and identify specific viruses suspended as bioaerosols. To test this concept, we aerosolized an innocuous replication-defective bovine adenovirus serotype 3 (BAdV3 in a controlled laboratory environment. The ASAP efficiently trapped the surrogate virus at 5×10E3 plaque-forming units (p.f.u. [2×10E5 genome copy equivalent] concentrations or more resulting in the successful detection of the virus using quantitative PCR. These results support the further development of ASAP for bioaerosol pathogen detection.

  14. EMI Quality Assurance Processes (PS06-4-499)

    Science.gov (United States)

    Aimar, A.; Alandes-Pradillo, M.; Cernak, J.; Dini, L.; Dongiovanni, D.; Kenny, E.

    2011-12-01

    The European Middleware Initiative (EMI) is the collaboration of the major European middleware providers, ARC, gLite, UNICORE, and dCache. It aims to deliver a consolidated set of middleware components for deployment in EGI and PRACE, extend the interoperability and integration between grids and other computing infrastructures, strengthen the reliability and manageability of the services and establish a sustainable model to support, harmonise and evolve the middleware, ensuring it responds to the requirements of the scientific communities relying on it. EMI will carry out the collective task of supporting and maintaining the middleware for their user communities. In order to enable the infrastructures to achieve this task, the middleware services must play an important role and mark a clear transition to more sustainable models by adopting best-practice service provision methods such as the ITIL processes or the ISO guidelines for software quality and validation. Repositories of packages, status reports, quality metrics and test and compliance programs are created and maintained to support the project software engineering activities and other providers of applications and services based on the EMI middleware. This article reports on the initial work of the EMI project and the solutions adopted for the software releases, development processes, quality compliance metrics and distribution repositories.

  15. EMI Quality Assurance Processes (PS06-4-499)

    International Nuclear Information System (INIS)

    The European Middleware Initiative (EMI) is the collaboration of the major European middleware providers, ARC, gLite, UNICORE, and dCache. It aims to deliver a consolidated set of middleware components for deployment in EGI and PRACE, extend the interoperability and integration between grids and other computing infrastructures, strengthen the reliability and manageability of the services and establish a sustainable model to support, harmonise and evolve the middleware, ensuring it responds to the requirements of the scientific communities relying on it. EMI will carry out the collective task of supporting and maintaining the middleware for their user communities. In order to enable the infrastructures to achieve this task, the middleware services must play an important role and mark a clear transition to more sustainable models by adopting best-practice service provision methods such as the ITIL processes or the ISO guidelines for software quality and validation. Repositories of packages, status reports, quality metrics and test and compliance programs are created and maintained to support the project software engineering activities and other providers of applications and services based on the EMI middleware. This article reports on the initial work of the EMI project and the solutions adopted for the software releases, development processes, quality compliance metrics and distribution repositories.

  16. Systematic Design of EMI-Resilient Negative-Feedback Amplifiers

    NARCIS (Netherlands)

    Van der Horst, M.J.

    2012-01-01

    The information transfer capacity of negative-feedback amplifiers, and electronic circuits in general, is limited by three fundamental limitations being noise, bandwidth, and signal power. Electromagnetic Interference (EMI) is not a fundamental limitation, but it also hampers the information transf

  17. Bioaerosol Analysis by Online Fluorescence Detection and Fluorescence Microscopy

    Science.gov (United States)

    Huffman, Alex; Pöhlker, Christopher; Treutlein, Bärbel; Pöschl, Ulrich

    2010-05-01

    Primary biological aerosol particles (PBAPs), including bacteria, spores and pollen, are essential for the spread of organisms and disease in the biosphere, and numerous studies have suggested that they may be important for atmospheric processes, including the formation of clouds and precipitation. The atmospheric abundance and size distribution of PBAPs, however, are largely unknown. At a semi-urban site in Mainz, Germany, we used an ultraviolet aerodynamic particle sizer (UV-APS) to measure fluorescent biological aerosol particles (FBAPs), which can be regarded as viable bioaerosol particles representing a lower limit for the actual abundance of PBAPs. Fluorescence of non-biological aerosol components are likely to influence the measurement results obtained for fine particles (pollen grains, respectively. The observed number concentrations and characteristic sizes of FBAPs are consistent with microscopic, biological and chemical analyses of PBAPs in aerosol filter samples. To our knowledge, however, this is the first study reporting continuous online measurements of bioaerosol particles over several months, a range of characteristic size distribution patterns, and a persistent bioaerosol peak at 3 μm. The measurement results confirm that PBAPs account for a substantial proportion of coarse aerosol particle number and mass in continental boundary layer air. Moreover, they suggest that the number concentration of viable bioparticles is dominated by fungal spores or agglomerated bacteria with aerodynamic diameters around 3 μm rather than single bacterial cells with diameters around 1 μm. Filter samples were later collected at the same sampling location and analyzed with a fluorescence microscope. By observing collected particles both with transmitted white light and with fluorescent emission from near-UV excitation, the technique provides information about whether individual particles are biological and regarding their viability. Characteristic images of FBAPs

  18. Investigating Density and Type of Bioaerosols in a Petrochemical Wastewater Treatment Plant: Mahshar - Iran, 2013

    OpenAIRE

    Mahdi Jahangiri; Masoud Neghab; Vahid Kahdemain; Reza Rostami; Ali Karimi; Mandana Aghabeigi; Abasali Kasayee Nasab

    2013-01-01

    Background and Objectives: Wastewater contains various pathogens including viruses, bacteria, fungi, etc. These microorganisms can easily become airborne during normal operations of wastewater treatment plant and contaminate the neighborhood environment. The aim of this study was to investigate the type and density of bioaerosols in a petrochemical wastewater treatment plant in Iran. Materials and Methods: In this cross sectional study, bioaerosols density was measured in different units o...

  19. Review of bioaerosols in indoor environment with special reference to sampling, analysis and control mechanisms.

    Science.gov (United States)

    Ghosh, Bipasha; Lal, Himanshu; Srivastava, Arun

    2015-12-01

    Several tiny organisms of various size ranges present in air are called airborne particles or bioaerosol which mainly includes live or dead fungi and bacteria, their secondary metabolites, viruses, pollens, etc. which have been related to health issues of human beings and other life stocks. Bio-terror attacks in 2001 as well as pandemic outbreak of flue due to influenza A H1N1 virus in 2009 have alarmed us about the importance of bioaerosol research. Hence characterization i.e. identification and quantification of different airborne microorganisms in various indoor environments is necessary to identify the associated risks and to establish exposure threshold. Along with the bioaerosol sampling and their analytical techniques, various literatures revealing the concentration levels of bioaerosol have been mentioned in this review thereby contributing to the knowledge of identification and quantification of bioaerosols and their different constituents in various indoor environments (both occupational and non-occupational sections). Apart from recognition of bioaerosol, developments of their control mechanisms also play an important role. Hence several control methods have also been briefly reviewed. However, several individual levels of efforts such as periodic cleaning operations, maintenance activities and proper ventilation system also serve in their best way to improve indoor air quality. PMID:26436919

  20. Theoretical studies on bioaerosol particle size and shape measurement from spatial scattering profiles

    Institute of Scientific and Technical Information of China (English)

    Chunxia Feng; Lihua Huang; Jianbo Wang; Yongkai Zhao; Huijie Huang

    2011-01-01

    @@ A method of clarifying bioaerosol particles is proposed based on T-matrix.Size and shape characterizations are simultaneously acquired for individual bioaerosol particles by analyzing the spatial distribution of scattered light.The particle size can be determined according to the scattering intensity,while shape information can be obtained through asymmetry factor(AF).The azimuthal distribution of the scattered light for spherical particles is symmetrical,whereas it is asymmetrical for non-spherical ones,and the asymmetry becomes intense with increasing asphericity.The calculated results denote that the 50-100 scattering angle is an effective range to classify the bioaerosol particles that we axe concerned of.The method is very useful in real-time environmental monitoring of particle sizes and shapes.%A method of clarifying bioaerosol particles is proposed based on T-matrix. Size and shape characterizations are simultaneously acquired for individual bioaerosol particles by analyzing the spatial distribution of scattered light. The particle size can be determined according to the scattering intensity, while shape information can be obtained through asymmetry factor (AF). The azimuthal distribution of the scattered light for spherical particles is symmetrical, whereas it is asymmetrical for non-spherical ones, and the asymmetry becomes intense with increasing asphericity. The calculated results denote that the 5°-10° scattering angle is an effective range to classify the bioaerosol particles that we are concerned of. The method is very useful in real-time environmental monitoring of particle sizes and shapes.

  1. Morphological characteristics of bioaerosols from contrasting locations in southern tropical India - A case study

    Science.gov (United States)

    Valsan, Aswathy E.; Priyamvada, Hema; Ravikrishna, R.; Després, Viviane R.; Biju, C. V.; Sahu, Lokesh K.; Kumar, Ashwini; Verma, R. S.; Philip, L.; Gunthe, Sachin S.

    2015-12-01

    Bioaerosols, which are ubiquitous in the earth's atmosphere, are poorly characterized in terms of their physical and chemical properties. Improved knowledge of their physical and chemical properties is essential to have a better understanding of their dispersion and long-range transport in the atmosphere and at the same time to assess their role as potential Ice Nuclei (IN). In the present work, possibly for the first time we report the morphological characteristics of bioaerosols from marine urban and high altitude continental regions in Southern India. The samples were collected using polycarbonate filter paper and analyzed using Scanning Electron Microscope (SEM) coupled with Energy-dispersive Spectra Detector (EDX/EDS). The observed bioaerosols exhibited great variability in their morphological features over this region of the world. At these contrasting environments, we found that fungal spores constituted the major fraction of the total observed bioaerosols. Pollen grains, plant and insect fragments, and lot of other non-identified bio-particles were also observed constituting the remaining fraction. Further, the classification of fungal spores exhibited strong variability over this region. For example, fungal spores of both Ascomycota and Basidiomycota class were seen in abundance in marine environment, while Ascomycota especially Cladosporium were seen in abundance in high altitude continental environment. Our findings also suggest that increase in diversity of bioaerosol particles at marine site appeared to coincide with precipitation. It appears that vast diversity in the morphological features of bioaerosols exists over this region, which should further be studied using advanced online techniques for better quantification under contrasting environments. However, the diversity observed in morphological characteristics of bioaerosols at these two contrasting locations is limited and restricted to these two sites and season of the year, and should therefore

  2. Prospects for using carbon-carbon composites for EMI shielding

    Science.gov (United States)

    Gaier, James R.

    1990-01-01

    Since pyrolyzed carbon has a higher electrical conductivity than most polymers, carbon-carbon composites would be expected to have higher electromagnetic interference (EMI) shielding ability than polymeric resin composites. A rule of mixtures model of composite conductivity was used to calculate the effect on EMI shielding of substituting a pyrolyzed carbon matrix for a polymeric matrix. It was found that the improvements were small, no more than about 2 percent for the lowest conductivity fibers (ex-rayon) and less than 0.2 percent for the highest conductivity fibers (vapor grown carbon fibers). The structure of the rule of mixtures is such that the matrix conductivity would only be important in those cases where it is much higher than the fiber conductivity, as in metal matrix composites.

  3. Consolidation and development roadmap of the EMI middleware

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Scientific research communities have benefited recently from the increasing availability of computing and data infrastructures with unprecedented capabilities for large scale distributed initiatives. These infrastructures are largely defined and enabled by the middleware they deploy. One of the major issues in the current usage of research infrastructures is the need to use similar but often incompatible middleware solutions. The European Middleware Initiative (EMI) is a collaboration of the major European middleware providers ARC, dCache, gLite and UNICORE. EMI aims to: deliver a consolidated set of middleware components for deployment in EGI, PRACE and other Distributed Computing Infrastructures; extend the interoperability between grids and other computing infrastructures; strengthen the reliability of the services; establish a sustainable model to maintain and evolve the middleware; fulfill the requirements of the user communities. This paper presents the consolidation and development objectives of the ...

  4. EMC Part Ⅲ :Sources of EMI

    Institute of Scientific and Technical Information of China (English)

    JohnWong

    2005-01-01

    1 Introduction The sources of EMI are both natural and human-made. Natural sources include sun and stars,as well as phenomena such as atmospherics,lightning,thunderstorms,and ESD(electrostatic discharge).On the other hand,any electrical orelectronics equipment qualifies as a potential human-made resource of EMI.Part I has listed most of common sources of EMI.This Part will detail a few of sources that we are concerned the most.

  5. Results of an EMI/RFI plant survey

    International Nuclear Information System (INIS)

    This paper summarizes the results of a telephone survey to collect information concerning electromagnetic interference/radio frequency interference (EMI/RFI) problems primarily at nuclear power plants. The survey found that problem sources such as two-way radios and welding have been largely resolved by procedural control and use of sound-power phone systems. Additional investigation and testing appear appropriate for noise interference related to grounding of electrical equipment and instrumentation

  6. Consolidation and development roadmap of the EMI middleware

    Science.gov (United States)

    Kónya, B.; Aiftimiei, C.; Cecchi, M.; Field, L.; Fuhrmann, P.; Nilsen, J. K.; White, J.

    2012-12-01

    Scientific research communities have benefited recently from the increasing availability of computing and data infrastructures with unprecedented capabilities for large scale distributed initiatives. These infrastructures are largely defined and enabled by the middleware they deploy. One of the major issues in the current usage of research infrastructures is the need to use similar but often incompatible middleware solutions. The European Middleware Initiative (EMI) is a collaboration of the major European middleware providers ARC, dCache, gLite and UNICORE. EMI aims to: deliver a consolidated set of middleware components for deployment in EGI, PRACE and other Distributed Computing Infrastructures; extend the interoperability between grids and other computing infrastructures; strengthen the reliability of the services; establish a sustainable model to maintain and evolve the middleware; fulfil the requirements of the user communities. This paper presents the consolidation and development objectives of the EMI software stack covering the last two years. The EMI development roadmap is introduced along the four technical areas of compute, data, security and infrastructure. The compute area plan focuses on consolidation of standards and agreements through a unified interface for job submission and management, a common format for accounting, the wide adoption of GLUE schema version 2.0 and the provision of a common framework for the execution of parallel jobs. The security area is working towards a unified security model and lowering the barriers to Grid usage by allowing users to gain access with their own credentials. The data area is focusing on implementing standards to ensure interoperability with other grids and industry components and to reuse already existing clients in operating systems and open source distributions. One of the highlights of the infrastructure area is the consolidation of the information system services via the creation of a common information

  7. EMI shielding composites based on magnetic nanoparticles and nanocarbons

    OpenAIRE

    Crespo Ribadeneyra, María

    2014-01-01

    The response of nanocomposites towards electromagnetic (EM) radiation can be tailored through the electrical conductivity, permittivity and magnetic permeability. Several composites with singular microstructures and containing either conductive nanoinclusions, magnetic nanoparticles or the combination of both, have been prepared and characterized. The performance of our materials as EM interference (EMI) shields, has been determined from 1 to 18 GHz and elucidated in terms of their electric a...

  8. Foams of polycaprolactone/MWNT nanocomposites for efficient EMI reduction

    OpenAIRE

    Thomassin, Jean-Michel; Pagnoulle, Christophe; Bednarz, Lukasz; Huynen, Isabelle; Jérôme, Robert; Detrembleur, Christophe

    2008-01-01

    Nanocomposites of polycaprolactone (PCL) filled with multi-walled carbon nanotubes (MWNTs) were foamed by supercritical CO2 in order to prepare materials with reduced electromagnetic interference (EMI). Two mixing techniques were used, i.e., melt blending and co-precipitation. Shielding efficiency as high as 60 to 80 dB together with a low reflectivity was observed at a very low vol% of MWNTs (0.25 vol%). The reflectivity of the nanocomposites was advantageously decreased upon foaming. The un...

  9. Determination of cerebral blood flow with the EMI CT scanner

    International Nuclear Information System (INIS)

    Cerebral blood flow (CBF) determinations were made in seven baboons and two patients with the EMI CT dedicated head scanner. The method for determining the CBF was tested and measurements were made during physiological states elicited by changes in pCO2 and depth of anaesthesia. The method has a number of advantages, particularly for assessing CBF responses to pCO2 changes. (author)

  10. Consolidation and development roadmap of the EMI middleware

    International Nuclear Information System (INIS)

    Scientific research communities have benefited recently from the increasing availability of computing and data infrastructures with unprecedented capabilities for large scale distributed initiatives. These infrastructures are largely defined and enabled by the middleware they deploy. One of the major issues in the current usage of research infrastructures is the need to use similar but often incompatible middleware solutions. The European Middleware Initiative (EMI) is a collaboration of the major European middleware providers ARC, dCache, gLite and UNICORE. EMI aims to: deliver a consolidated set of middleware components for deployment in EGI, PRACE and other Distributed Computing Infrastructures; extend the interoperability between grids and other computing infrastructures; strengthen the reliability of the services; establish a sustainable model to maintain and evolve the middleware; fulfil the requirements of the user communities. This paper presents the consolidation and development objectives of the EMI software stack covering the last two years. The EMI development roadmap is introduced along the four technical areas of compute, data, security and infrastructure. The compute area plan focuses on consolidation of standards and agreements through a unified interface for job submission and management, a common format for accounting, the wide adoption of GLUE schema version 2.0 and the provision of a common framework for the execution of parallel jobs. The security area is working towards a unified security model and lowering the barriers to Grid usage by allowing users to gain access with their own credentials. The data area is focusing on implementing standards to ensure interoperability with other grids and industry components and to reuse already existing clients in operating systems and open source distributions. One of the highlights of the infrastructure area is the consolidation of the information system services via the creation of a common information

  11. Monitoring of bone healing by piezoelectric-EMI method

    Science.gov (United States)

    Mazlina, M. H.; Sarpinah, Bibi; Tawie, Rudy; Daho, Claira Dalislone; Annuar, Ishak

    2016-02-01

    Smart Piezoelectric devices which have excellent piezoelectric properties have been employed for various sensor and actuators applications. The work presented here is an attempt to demonstrate the feasibility of bone healing monitoring by using piezoelectric-electromechanical impedance (EMI) method that have several advantages such as low cost, portable, light weight and simplicity in measurement. A Piezoelectric sensor (PZT) has been widely used in damage detection of various structures including concrete, pipes and bones due to their unique sensing and actuating properties. The EMI technique has emerged as a universal Structural Health Monitoring (SHM) tool suitable for almost all engineering materials and structures. The method used for this proposed study consists of put healing agent in the host structure in particular cracks bone to be monitored by PZT-needle sensor which is embedded to the host structure. The measurements were taken in the frequency range between 0.04 to 100 kHz at 1 kHz interval using AD5933 evaluation board. The signals retrieved from the AD5933 evaluation board, were quantify and analyse to obtain Root Mean Square Deviation (RMSD) percentage value. Measurements were taken every hour for 12 hours. The result from the study shows the feasibility of the piezoelectric-EMI method to effectively detect changes during bone-cracks healing process until the cracks bone is fully recovered.

  12. Mixed Mode EMI Noise Level Measurement in SMPS

    Directory of Open Access Journals (Sweden)

    R. Dhanasekaran

    2006-01-01

    Full Text Available Fast switching in SMPS generate large amount of Electromagnetic Interference (EMI.The proposed method to determine Common Mode (CM and Differential Mode (DM noise of a low power Switched Mode Power Supply (SMPS using two-probe approach i.e. using one current probe as an injecting probe and other current probe as receiving probe Common Mode (CM noise is measured between power line and ground. Differential Mode (DM noise is measured between each power lines. EMI radiated emissions occur in the range of 150 KHz-30MHz. EMI filter is usually needed in the input of the Switch Mode Power Supply (SMPS to attenuate the noise. The proposed approach allows measurement of noise level in Switched Mode Power Supply without interleaving its normal operation. With proper set up calibration, the proposed approach can be used to measure the noise level with reasonable accuracy. The noise level is measure from the frequency of 1MHz-3MHz using signal generator the signal is induced in the injected probe and using receiving probe noise level is measured in db using spectrum analyser.

  13. Autofluorescence of atmospheric bioaerosols – fluorescent biomolecules and potential interferences

    Directory of Open Access Journals (Sweden)

    C. Pöhlker

    2012-01-01

    Full Text Available Primary biological aerosol particles (PBAP are an important subset of air particulate matter with a substantial contribution to the organic aerosol fraction and potentially strong effects on public health and climate. Recent progress has been made in PBAP quantification by utilizing real-time bioaerosol detectors based on the principle that specific organic molecules of biological origin such as proteins, coenzymes, cell wall compounds and pigments exhibit intrinsic fluorescence. The properties of many fluorophores have been well documented, but it is unclear which are most relevant for detection of atmospheric PBAP. The present study provides a systematic synthesis of literature data on potentially relevant biological fluorophores. We analyze and discuss their relative importance for the detection of fluorescent biological aerosol particles (FBAP by online instrumentation for atmospheric measurements such as the ultraviolet aerodynamic particle sizer (UV-APS or the wide issue bioaerosol sensor (WIBS.

    In addition, we provide new laboratory measurement data for selected compounds using bench-top fluorescence spectroscopy. Relevant biological materials were chosen for comparison with existing literature data and to fill in gaps of understanding. The excitation-emission matrices (EEM exhibit pronounced peaks at excitation wavelengths of ~280 nm and ~360 nm, confirming the suitability of light sources used for online detection of FBAP. They also show, however, that valuable information is missed by instruments that do not record full emission spectra at multiple wavelengths of excitation, and co-occurrence of multiple fluorophores within a detected sample will likely confound detailed molecular analysis. Selected non-biological materials were also analyzed to assess their possible influence on FBAP detection and generally exhibit only low levels of background-corrected fluorescent emission. This study strengthens the hypothesis that ambient

  14. Autofluorescence of atmospheric bioaerosols – fluorescent biomolecules and potential interferences

    Directory of Open Access Journals (Sweden)

    C. Pöhlker

    2011-09-01

    Full Text Available Primary biological aerosol particles (PBAP are an important subset of air particulate matter with a substantial contribution to the organic aerosol fraction and potentially strong effects on public health and climate. Recent progress has been made in PBAP quantification by utilizing real-time bioaerosol detectors based on the principle that specific organic molecules of biological origin such as proteins, coenzymes, cell wall compounds and pigments exhibit intrinsic fluorescence. The properties of many fluorophores have been well documented, but it is unclear which are most relevant for detection of atmospheric PBAP. The present study provides a systematic synthesis of literature data on potentially relevant biological fluorophores. We analyze and discuss their relative importance for the detection of fluorescent biological aerosol particles (FBAP by online instrumentation for atmospheric measurements such as the ultraviolet aerodynamic particle sizer (UV-APS or the wide issue bioaerosol sensor (WIBS.

    In addition, we provide new laboratory measurement data for selected compounds using bench-top fluorescence spectroscopy. Relevant biological materials were chosen for comparison with existing literature data and to fill in gaps of understanding. The excitation-emission matrices (EEM exhibit pronounced peaks at excitation wavelengths of ~280 nm and ~360 nm, confirming the suitability of light sources used for online detection of FBAP. They also show, however, that valuable information is missed by instruments that do not record full emission spectra at multiple wavelengths of excitation, and co-occurrence of multiple fluorophores within a detected sample will likely confound detailed molecular analysis. Selected non-biological materials were also analyzed to assess their possible influence on FBAP detection and generally exhibit only low levels of background-corrected fluorescent emission. This study strengthens the hypothesis that ambient

  15. Electromagnetic interference (EMI) shielding of single-walled carbon nanotube epoxy composites.

    Science.gov (United States)

    Li, Ning; Huang, Yi; Du, Feng; He, Xiaobo; Lin, Xiao; Gao, Hongjun; Ma, Yanfeng; Li, Feifei; Chen, Yongsheng; Eklund, Peter C

    2006-06-01

    Single-walled carbon nanotube (SWNT)-polymer composites have been fabricated to evaluate the electromagnetic interference (EMI) shielding effectiveness (SE) of SWNTs. Our results indicate that SWNTs can be used as effective lightweight EMI shielding materials. Composites with greater than 20 dB shielding efficiency were obtained easily. EMI SE was tested in the frequency range of 10 MHz to 1.5 GHz, and the highest EMI shielding efficiency (SE) was obtained for 15 wt % SWNT, reaching 49 dB at 10 MHz and exhibiting 15-20 dB in the 500 MHz to 1.5 GHz range. The EMI SE was found to correlate with the dc conductivity, and this frequency range is found to be dominated by reflection. The effects of SWNT wall defects and aspect ratio on the EMI SE were also studied. PMID:16771569

  16. Bio-Aerosol Detection Using Mass Spectrometry: Public Health Applications

    Energy Technology Data Exchange (ETDEWEB)

    Ludvigson, Laura D. [Univ. of California, Berkeley, CA (United States)

    2004-01-01

    I recently spent a summer as an intern at the Lawrence Livermore National Laboratory. I worked on a project involving the real-time, reagentless, single cell detection of aerosolized pathogens using a novel mass spectrometry approach called Bio-Aerosol Mass Spectrometry (BAMS). Based upon preliminary results showing the differentiation capabilities of BAMS, I would like to explore the development and use of this novel detection system in the context of both environmental and clinical sample pathogen detection. I would also like to explore the broader public health applications that a system such as BAMS might have in terms of infectious disease prevention and control. In order to appreciate the potential of this instrument, I will demonstrate the need for better pathogen detection methods, and outline the instrumentation, data analysis and preliminary results that lead me toward a desire to explore this technology further. I will also discuss potential experiments for the future along with possible problems that may be encountered along the way.

  17. Bio-Aerosol Detection Using Mass Spectrometry: Public Health Applications

    Energy Technology Data Exchange (ETDEWEB)

    Ludvigson, L D

    2004-03-05

    I recently spent a summer as an intern at the Lawrence Livermore National Laboratory. I worked on a project involving the real-time, reagentless, single cell detection of aerosolized pathogens using a novel mass spectrometry approach called Bio-Aerosol Mass Spectrometry (BAMS). Based upon preliminary results showing the differentiation capabilities of BAMS, I would like to explore the development and use of this novel detection system in the context of both environmental and clinical sample pathogen detection. I would also like to explore the broader public health applications that a system such as BAMS might have in terms of infectious disease prevention and control. In order to appreciate the potential of this instrument, I will demonstrate the need for better pathogen detection methods, and outline the instrumentation, data analysis and preliminary results that lead me toward a desire to explore this technology further. I will also discuss potential experiments for the future along with possible problems that may be encountered along the way.

  18. Single particle multichannel bio-aerosol fluorescence sensor

    Science.gov (United States)

    Kaye, P. H.; Stanley, W. R.; Hirst, E.; Foot, E. V.; Baxter, K. L.; Barrington, S. J.

    2005-05-01

    We describe a prototype low-cost multi-channel aerosol fluorescence sensor designed for unattended deployment in medium to large area bio-aerosol detection networks. Individual airborne particles down to ~1μm in size are detected and sized by measurement of light scattered from a continuous-wave diode laser (660nm). This scatter signal is then used to trigger the sequential firing of two xenon sources which irradiate the particle with UV pulses at ~280 nm and ~370 nm, optimal for excitation of bio-fluorophores tryptophan and NADH (nicotinamide adenine dinucleotide) respectively. For each excitation wavelength, fluorescence is detected across two bands embracing the peak emissions of the same bio-fluorophores. Current measurement rates are up to ~125 particles/s, corresponding to all particles for concentrations up to 1.3 x 104 particles/l. Developments to increase this to ~500 particles/s are in hand. Device sensitivity is illustrated in preliminary data recorded from aerosols of E.coli, BG spores, and a variety of non-biological materials.

  19. Cluster analysis of WIBS single particle bioaerosol data

    Directory of Open Access Journals (Sweden)

    N. H. Robinson

    2012-09-01

    Full Text Available Hierarchical agglomerative cluster analysis was performed on single-particle multi-spatial datasets comprising optical diameter, asymmetry and three different fluorescence measurements, gathered using two dual Waveband Integrated Bioaerosol Sensor (WIBS. The technique is demonstrated on measurements of various fluorescent and non-fluorescent polystyrene latex spheres (PSL before being applied to two separate contemporaneous ambient WIBS datasets recorded in a forest site in Colorado, USA as part of the BEACHON-RoMBAS project. Cluster analysis results between both datasets are consistent. Clusters are tentatively interpreted by comparison of concentration time series and cluster average measurement values to the published literature (of which there is a paucity to represent: non-fluorescent accumulation mode aerosol; bacterial agglomerates; and fungal spores. To our knowledge, this is the first time cluster analysis has been applied to long term online PBAP measurements. The novel application of this clustering technique provides a means for routinely reducing WIBS data to discrete concentration time series which are more easily interpretable, without the need for any a priori assumptions concerning the expected aerosol types. It can reduce the level of subjectivity compared to the more standard analysis approaches, which are typically performed by simple inspection of various ensemble data products. It also has the advantage of potentially resolving less populous or subtly different particle types. This technique is likely to become more robust in the future as fluorescence-based aerosol instrumentation measurement precision, dynamic range and the number of available metrics is improved.

  20. SSCG methods of EMI emissions reduction applied to switching power converters

    OpenAIRE

    Santolaria Lorenzo, José Alfonso

    2004-01-01

    Many methods for EMI suppression have been developed in the last fifty years, most of them, showing a hardly change in its implementation. Traditional tools for EMI suppression are related to the use of filters, shielding techniques and new methods for layout improvement. These hardware techniques are normally supported with waveform shapes having themselves a lower spectral content. This kind of signals makes part of a different concept of EMI suppression that consists of limiting the spectr...

  1. Factors Affecting Vegetable Growers’ Exposure to Fungal Bioaerosols and Airborne Dust

    DEFF Research Database (Denmark)

    Hansen, V. M.; Meyling, Nicolai; Winding, Anne;

    2012-01-01

    with personal and stationary filter samplers. Selected fungal species (Beauveria spp., Trichoderma spp., Penicillium olsonii, and Penicillium brevicompactum) were identified using different polymerase chain reaction-based methods and sequencing. We found that the factors (i) work task, (ii) crop, including......We have quantified vegetable growers’ exposure to fungal bioaerosol components including (1/3)-b-d-glucan (b-glucan), total fungal spores, and culturable fungal units. Furthermore, we have evaluated factors that might affect vegetable growers’ exposure to fungal bioaerosols and airborne dust....... Investigated environments included greenhouses producing cucumbers and tomatoes, open fields producing cabbage, broccoli, and celery, and packing facilities. Measurements were performed at different times during the growth season and during execution of different work tasks. Bioaerosols were collected...

  2. Evaluation of exposure-response relationships for health effects of microbial bioaerosols - A systematic review.

    Science.gov (United States)

    Walser, Sandra M; Gerstner, Doris G; Brenner, Bernhard; Bünger, Jürgen; Eikmann, Thomas; Janssen, Barbara; Kolb, Stefanie; Kolk, Annette; Nowak, Dennis; Raulf, Monika; Sagunski, Helmut; Sedlmaier, Nadja; Suchenwirth, Roland; Wiesmüller, Gerhard; Wollin, Klaus-Michael; Tesseraux, Irene; Herr, Caroline E W

    2015-10-01

    Studies suggest adverse health effects following exposure to bioaerosols in the environment and in particular at workplaces. However, there is still a lack of health-related exposure limits based on toxicological or epidemiological studies from environmental health or from the working environment. The aim of this study was to derive health-based exposure limits for bioaerosols that can protect the general population as group "at risk" via environmental exposure using analysis of peer-reviewed studies related to occupational medicine, indoor air and environmental health. The derivation of exposure limits should be conducted by the members of a bioaerosol expert panel according to established toxicological criteria. A systematic review was performed in Medline (PubMed) including studies containing both data on exposure measurements and observed health outcomes. In addition, literature recommended by the experts was considered. A comprehensive search strategy was generated and resulted in a total of n=1569 studies in combination with the literature recommendations. Subsequently, abstracts were screened using defined exclusion criteria yielding a final number of n=44 studies. A standardized extraction sheet was used to combine data on health effects and exposure to different bioaerosols. After full-text screening and extraction according to the defined exclusion criteria n=20 studies were selected all related to occupational exposures comprising the working areas wood processing, farming, waste processing and others. These studies were analyzed in collaboration with the bioaerosol expert network in terms of suitability for derivation of health-related exposure limits. The bioaerosol expert network concluded that none of the analyzed studies provided suitable dose-response relationships for derivation of exposure limits. The main reasons were: (1) lack of studies with valid dose-response data; (2) diversity of employed measuring methods for microorganisms and bioaerosol

  3. [The microbiological characterization of the bioaerosol and leachate from an urban solid refuse dump: preliminary data].

    Science.gov (United States)

    Borrello, P; Gucci, P M; Musmeci, L; Pirrera, A

    1999-01-01

    The present paper shows the results of an experimental study aimed at arranging a microbiological characterization of bioaerosol and leachate resulting from a sanitary landfill for solid urban waste situated near Rome. Bioaerosol sampling was performed by using the active sampling method referred to as surface air system, that is extensively used during indoor environmental monitoring. The microorganisms (bacteria and fungi) believed to be of relevance on bioaerosol and leachate with a view to hygienic risks, were investigated in order to estimate the potential risks to which the population and the workers can be exposed and consequently to allow corrective measures by monitoring campaigns of the examined matrices and by models of low environmental impact landfill. PMID:10721214

  4. Lightweight graphene nanoplatelet/boron carbide composite with high EMI shielding effectiveness

    OpenAIRE

    Yongqiang Tan; Heng Luo; Haibin Zhang; Xiaosong Zhou; Shuming Peng

    2016-01-01

    Lightweight graphene nanoplatelet (GNP)/boron carbide (B4C) composites were prepared and the effect of GNPs loading on the electromagnetic interference (EMI) shielding effectiveness (SE) has been evaluated in the X-band frequency range. Results have shown that the EMI SE of GNP/B4C composite increases with increasing the GNPs loading. An EMI SE as high as 37 ∼ 39 dB has been achieved in composite with 5 vol% GNPs. The high EMI SE is mainly attributed to the high electrical conductivity, high ...

  5. Standoff detection of natural bioaerosol by range-gated laser-induced fluorescence spectroscopy

    Science.gov (United States)

    Buteau, Sylvie; Simard, Jean-Robert; Roy, Gilles

    2005-11-01

    The biological threat has emerged as one of today's primary security challenges due to the increased accessibility to biological warfare technology and the limited efficiency of detection and protection measures against such menace. Defence Research and Development Canada (DRDC) has investigated various methods, including the improvement of atmospheric bioaerosol monitoring, to increase the readiness against such threat. By the end of the 90s, DRDC developed a standoff bioaerosol sensor based on intensified range-gated spectrometric detection of Laser Induced Fluorescence (LIF). This work has showed an important potential of detecting and discriminating in real-time several bioaerosols. The LIDAR system that monitors atmosphere cells from a standoff position induces specific spectrally wide fluorescence signals originating from inelastic interactions with complex molecules forming the building blocks of the bioaerosols. This LIF signal is spectrally collected by a combination of a dispersive element and a range-gated ICCD that records the spectral information within a range-selected atmospheric volume. To assess further the potential of discrimination of such technique, this innovative sensor was used to obtain spectral data of various natural bioaerosols. In order to evaluate the discrimination of biological agent simulants from naturally occurring background fluorescing materials, the obtained results were compared with the ones of bioaerosol simulants (Bacillius subtilis var globiggi (BG) and Erwinia herbicola (EH)) acquired in 2001. The robustness of the spectral data with time was also investigated. From our results, most of the studied natural materials showed a spectral shift of various degrees, and up to 10 nm, to the longer wavelength one year later.

  6. Bioaerosols from a Food Waste Composting Plant Affect Human Airway Epithelial Cell Remodeling Genes

    Directory of Open Access Journals (Sweden)

    Ming-Wei Chang

    2013-12-01

    Full Text Available The composting procedure in food waste plants generates airborne bioaerosols that have the potential to damage human airway epithelial cells. Persistent inflammation and repair responses induce airway remodeling and damage to the respiratory system. This study elucidated the expression changes of airway remodeling genes in human lung mucoepidermoid NCI-H292 cells exposed to bioaerosols from a composting plant. Different types of microorganisms were detectable in the composting plant, using the agar culture method. Real-time polymerase chain reaction was used to quantify the level of Aspergillus fumigatus and the profile of remodeling genes. The real-time PCR results indicated that the amount of A. fumigatus in the composting hall was less than 102 conidia. The endotoxins in the field bioaerosols were determined using a limulus amebocyte lysate test. The endotoxin levels depended on the type of particulate matter (PM, with coarse particles (2.5–10 μm having higher endotoxin levels than did fine particles (0.5–2.5 μm. After exposure to the conditioned medium of field bioaerosol samples, NCI-H292 cells showed increased pro-inflammatory interleukin (IL-6 release and activated epidermal growth factor receptor (EGFR, transforming growth factor (TGF-β1 and cyclin-dependent kinase inhibitor 1 (p21WAF1/CIP1 gene expression, but not of matrix metallopeptidase (MMP-9. Airborne endotoxin levels were higher inside the composting hall than they were in other areas, and they were associated with PM. This suggested that airborne bioaerosols in the composting plant contained endotoxins and microorganisms besides A. fumigatus that cause the inflammatory cytokine secretion and augment the expression of remodeling genes in NCI-H292 cells. It is thus necessary to monitor potentially hazardous materials from bioaerosols in food composting plants, which could affect the health of workers.

  7. EMI investigation and modeling of a flat panel display

    Science.gov (United States)

    Shinde, Satyajeet

    It is often important to carry out EMI analysis in the design phase of an electronic product to predict the radiated emissions. An EMI analysis is important to predict if the product complies with the FCC regulations as well as to gain an understanding of the noise coupling and radiation mechanisms. EMI analysis and prediction of radiated emissions in electronic products that have an electrically large chassis, pose a challenge due to the presence of multiple resonant structures and noise-coupling mechanisms. The study focusses on the investigation of the main noise coupling mechanisms, the approach and methods used for the modeling of a flat panel display. Full-wave simulation models are a powerful tool for the prediction of radiated emissions and the visualization of coupling paths within the product. The first part deals with the measurement of radiated emissions from the display under standard test conditions and the identification of the main noise sources using near-field scanning. The contribution of the chassis components - frame, back cover and the back panel, to the radiated emission is analyzed using shielding measurements. Noise coupling from the main board, flex cables, display driver boards and the display is analyzed from measurements. The second part deals with the full-wave modeling of the components - main board, flex cables, chassis and the display driver boards. The modeling approach is demonstrated by highlighting some of the challenges in modeling larger structures having many details. The simulation model contains the main components of the TV that contribute to far-field radiation. The full-wave modeling is done using the CST Microwave Studio. Two sets of simulation models are described - the common mode models and the complete models. The use of the common mode models for the identification of the resonant structures is demonstrated. The far-field radiated emissions along with the coupling mechanism within the flat panel display can be

  8. Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed.

    Science.gov (United States)

    Lanier, Caroline; André, Véronique; Séguin, Virginie; Heutte, Natacha; El Kaddoumi, Anne; Bouchart, Valérie; Picquet, Rachel; Garon, David

    2012-01-01

    Agricultural occupations associated with animal breeding and the processing of animal materials in confinement systems could potentially lead to bioaerosol exposures. Moulds and mycotoxins could be constituents of bioaerosols and should be studied because of their possible involvement in respiratory diseases and cancers. In order to characterize the fungal contamination of the indoor air in a dairy barn, bioaerosols were collected during 20 days in a cattle farm located in Normandy (France). Mycobiota, mycotoxins and the mutagenicity of bioaerosols were studied. The toxigenic ability of Aspergillus flavus group and Aspergillus fumigatus isolates was also evaluated in vitro. The prevalent airborne moulds were from the following potentially toxigenic species: Aspergillus flavus group, Aspergillus fumigatus, Penicillium chrysogenum, Stachybotrys chartarum, and the allergenic species Ulocladium chartarum, Cladosporium cladosporioides. In comparison with harvesting, grain handling or broiler breeding, the concentrations of viable moulds were lower in the cattle shed. Seasonal variations in levels of several species were also observed. This study revealed that aflatoxins were detected in bioaerosols and, for the first time, showed that farmers are possibly exposed to Stachybotrys chartarum during routine barn work. Moreover, the finding of mutagenicity from bioaerosols needs further investigations on bioaerosol composition. PMID:22462447

  9. De Par en Par (Wide Open), 1993.

    Science.gov (United States)

    De Par en Par, 1993

    1993-01-01

    This document consists of the four issues of the serial "De Par en Par" published during 1993. This serial provides lessons in Spanish for elementary school children. It is written by bilingual education teachers for use in the bilingual classroom. The magazine bases itself on the K-6 curriculum and offers a variety of activities for classroom…

  10. FTG扩展频谱降低EMI%EMI reduction technique employs spread spectrum in the FTGs

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ 电磁干扰(EMI)是设计人员在制造产品时必须处理的一个问题.随着器件速度的增加和封装尺寸的减小,使得产生EMI的可能性显著增加.除了机箱内的干扰外,保证各系统不互相干扰是至关重要的.现在有一系列的政府管理的EMI测试,要求产品必须无干扰.

  11. Design Of EMI Filter For Flash Lamp Power Supply

    Directory of Open Access Journals (Sweden)

    Amrita Bhatt

    2015-08-01

    Full Text Available Abstract Conducted and radiated electromagnetic interference in embedded and VLSI systems have become important in recent years with increase in clock frequency and reduction in physical dimensions of interconnects. It is important to understand the noise components in terms of current paths and the mitigation techniques. Although the common mode and differential mode components of conducted noise are analyzed in the context of a power electronics system the analytical and theoretical techniques hold good for other domains as well such as embedded systems and VLSI. This paper deals with modelling design and development of an EMI filter for conducted mode noise in flash lamp power supply. Also a design procedure of EMI filters sustaining to the military standard 461E is presented and it is based on practical measurement of conducted emissions. Design procedure in this paper considers common mode and differential mode separately. The paper also consists of considerations for magnetic core material integrated common mode CM common mode choke size optimization and differential mode DM choke etc. Design examples are given and are experimentally verified.

  12. Prediction of shipboard electromagnetic interference (EMI) problems using artificial intelligence (AI) technology

    Science.gov (United States)

    Swanson, David J.

    1990-01-01

    The electromagnetic interference prediction problem is characteristically ill-defined and complicated. Severe EMI problems are prevalent throughout the U.S. Navy, causing both expected and unexpected impacts on the operational performance of electronic combat systems onboard ships. This paper focuses on applying artificial intelligence (AI) technology to the prediction of ship related electromagnetic interference (EMI) problems.

  13. Research on EMI Reduction of Interleaved Bridgeless Power Factor Corrector using Frequency Dithering

    DEFF Research Database (Denmark)

    Li, Qingnan; Thomsen, Ole Cornelius; Andersen, Michael A. E.

    2012-01-01

    W universal line 2-stage IBPFC for class-D amplifiers. Detailed evaluations of impacts on EMI reduction from frequency dithering are carried out through both of the theoretical and experimental analysis. Furthermore, the impact on EMI filter's performances under frequency dithering condition is also...

  14. Research on EMI Reduction of Multi-stage Interleaved Bridgeless Power Factor Corrector

    DEFF Research Database (Denmark)

    Li, Qingnan; Thomsen, Ole Cornelius; Andersen, Michael A. E.

    2012-01-01

    Working as an electronic pollution eliminator, the Power Factor Corrector's (PFC) own Electromagnetic Interference (EMI) problems have been blocking its performance improvement for long. In this paper, a systematic research on EMI generation of a multi-stage Two-Boost-Circuit Interleaved Bridgeless...

  15. Estimated occupational risk from bioaerosols generated during land application of Class B biosolids

    Science.gov (United States)

    It has been speculated that bioaerosols generated during land application of biosolids pose a serious occupational risk, but few scientific studies have been performed to assess levels of aerosolization of microorganisms from biosolids and to estimate the occupational risks of infection. This study ...

  16. Seasonal distribution of microbial activity in bioaerosols in the outdoor environment of the Qingdao coastal region

    Science.gov (United States)

    Zhong, Xi; Qi, Jianhua; Li, Hongtao; Dong, Lijie; Gao, Dongmei

    2016-09-01

    Microbial activities in the atmosphere can indicate the physiological processes of microorganisms and can indirectly affect cloud formation and environmental health. In this study, the microbial activity in bioaerosols collected in the Qingdao coastal region was investigated using the fluorescein diacetate (FDA) hydrolysis method to detect the enzyme activity of microorganisms. The results showed that the microbial activity ranged from 5.49 to 102 ng/m3 sodium fluorescein from March 2013 to February 2014; the average value was 34.4 ng/m3. Microbial activity has no statistical correlation with total microbial quantity. Multiple linear regression analysis showed that meteorological factors such as atmospheric temperature, relative humidity and wind speed accounted for approximately 35.7% of the variation of the microbial activity, although their individual impacts on microbial activity varied. According to the correlation analysis, atmospheric temperature and wind speed had a significant positive and negative influence on microbial activity, respectively, whereas relative humidity and wind direction had no significant influence. The seasonal distribution of microbial activity in bioaerosols was in the order of summer > autumn > winter > spring, with high fluctuations in the summer and autumn. Microbial activity in bioaerosols differed in different weather conditions such as the sunny, foggy, and hazy days of different seasons. Further in situ observations in different weather conditions at different times and places are needed to understand the seasonal distribution characteristics of microbial activity in bioaerosols and the influence factors of microbial activity.

  17. Exposure to Airborne Noroviruses and Other Bioaerosol Components at a Wastewater Treatment Plant in Denmark

    DEFF Research Database (Denmark)

    Uhrbrand, Katrine; Schultz, Anna Charlotte; Madsen, Anne Mette

    2011-01-01

    Exposure to bioaerosols associated with wastewater treatment processes may represent an occupational health risk for workers at wastewater treatment plants (WWTPs). A high frequency of acute symptoms in the gastrointestinal tract among the wastewater workers at a Danish WWTP has been reported...

  18. Lightweight graphene nanoplatelet/boron carbide composite with high EMI shielding effectiveness

    Science.gov (United States)

    Tan, Yongqiang; Luo, Heng; Zhang, Haibin; Zhou, Xiaosong; Peng, Shuming

    2016-03-01

    Lightweight graphene nanoplatelet (GNP)/boron carbide (B4C) composites were prepared and the effect of GNPs loading on the electromagnetic interference (EMI) shielding effectiveness (SE) has been evaluated in the X-band frequency range. Results have shown that the EMI SE of GNP/B4C composite increases with increasing the GNPs loading. An EMI SE as high as 37 ˜ 39 dB has been achieved in composite with 5 vol% GNPs. The high EMI SE is mainly attributed to the high electrical conductivity, high dielectric loss as well as multiple reflections by aligned GNPs inside the composite. The GNP/B4C composite is demonstrated to be promising candidate of high-temperature microwave EMI shielding material.

  19. Lightweight graphene nanoplatelet/boron carbide composite with high EMI shielding effectiveness

    Directory of Open Access Journals (Sweden)

    Yongqiang Tan

    2016-03-01

    Full Text Available Lightweight graphene nanoplatelet (GNP/boron carbide (B4C composites were prepared and the effect of GNPs loading on the electromagnetic interference (EMI shielding effectiveness (SE has been evaluated in the X-band frequency range. Results have shown that the EMI SE of GNP/B4C composite increases with increasing the GNPs loading. An EMI SE as high as 37 ∼ 39 dB has been achieved in composite with 5 vol% GNPs. The high EMI SE is mainly attributed to the high electrical conductivity, high dielectric loss as well as multiple reflections by aligned GNPs inside the composite. The GNP/B4C composite is demonstrated to be promising candidate of high-temperature microwave EMI shielding material.

  20. Par-tjek Manualen

    DEFF Research Database (Denmark)

    Trillingsgaard, Tea; Due, Mattias Stølen; Nørr Fentz, Hanne;

    Par-tjek er et tilbud til par, der ønsker at styrke forholdet og forebygge vanskeligheder. Et Par-tjek består af et indledende online spørgeskema efterfulgt at to samtaler med en psykolog eller lignende vejleder. Ved den sidste samtale modtager parret en personlig feedback-rapport, som de kan...

  1. Presence of Legionella and free-living Amoebae in composts and bioaerosols from composting facilities.

    Science.gov (United States)

    Conza, Lisa; Pagani, Simona Casati; Gaia, Valeria

    2013-01-01

    Several species of Legionella cause Legionnaires' disease (LD). Infection may occur through inhalation of Legionella or amoebal vesicles. The reservoirs of Legionella are water, soil, potting soil and compost. Some species of free-living amoebae (FLA) that are naturally present in water and soil were described as hosts for Legionella. This study aimed to understand whether or not the composting facilities could be sources of community-acquired Legionella infections after development of bioaerosols containing Legionella or FLA. We looked for the presence of Legionella (by co-culture) and FLA (by culture) in composts and bioaerosols collected at four composting facilities located in southern Switzerland. We investigated the association between the presence of Legionella and compost and air parameters and presence of FLA. Legionella spp. (including L. pneumophila) were detected in 69.3% (61/88) of the composts and FLA (mainly Acanthamoeba, Vermamoeba, Naegleria and Stenamoeba) in 92.0% (81/88). L. pneumophila and L. bozemanii were most frequently isolated. FLA as potential host for Legionella spp. were isolated from 40.9% (36/88) of the composts in all facilities. In Legionella-positive samples the temperature of compost was significantly lower (P = 0.012) than in Legionella-negative samples. Of 47 bioaerosol samples, 19.1% (9/47) were positive for FLA and 10.6% (5/47) for L. pneumophila. Composts (62.8%) were positive for Legionella and FLA contemporaneously, but both microorganisms were never detected simultaneously in bioaerosols. Compost can release bioaerosol containing FLA or Legionella and could represent a source of infection of community-acquired Legionella infections for workers and nearby residents.

  2. Presence of Legionella and free-living Amoebae in composts and bioaerosols from composting facilities.

    Directory of Open Access Journals (Sweden)

    Lisa Conza

    Full Text Available Several species of Legionella cause Legionnaires' disease (LD. Infection may occur through inhalation of Legionella or amoebal vesicles. The reservoirs of Legionella are water, soil, potting soil and compost. Some species of free-living amoebae (FLA that are naturally present in water and soil were described as hosts for Legionella. This study aimed to understand whether or not the composting facilities could be sources of community-acquired Legionella infections after development of bioaerosols containing Legionella or FLA. We looked for the presence of Legionella (by co-culture and FLA (by culture in composts and bioaerosols collected at four composting facilities located in southern Switzerland. We investigated the association between the presence of Legionella and compost and air parameters and presence of FLA. Legionella spp. (including L. pneumophila were detected in 69.3% (61/88 of the composts and FLA (mainly Acanthamoeba, Vermamoeba, Naegleria and Stenamoeba in 92.0% (81/88. L. pneumophila and L. bozemanii were most frequently isolated. FLA as potential host for Legionella spp. were isolated from 40.9% (36/88 of the composts in all facilities. In Legionella-positive samples the temperature of compost was significantly lower (P = 0.012 than in Legionella-negative samples. Of 47 bioaerosol samples, 19.1% (9/47 were positive for FLA and 10.6% (5/47 for L. pneumophila. Composts (62.8% were positive for Legionella and FLA contemporaneously, but both microorganisms were never detected simultaneously in bioaerosols. Compost can release bioaerosol containing FLA or Legionella and could represent a source of infection of community-acquired Legionella infections for workers and nearby residents.

  3. Enhancing bioaerosol sampling by Andersen impactors using mineral-oil-spread agar plate.

    Directory of Open Access Journals (Sweden)

    Zhenqiang Xu

    Full Text Available As a bioaerosol sampling standard, Andersen type impactor is widely used since its invention in 1950s, including the investigation of the anthrax attacks in the United States in 2001. However, its related problems such as impaction and desiccation stress as well as particle bounce have not been solved. Here, we improved its biological collection efficiencies by plating a mineral oil layer (100 µL onto the agar plate. An Andersen six-stage sampler and a BioStage impactor were tested with mineral-oil-spread agar plates in collecting indoor and outdoor bacterial and fungal aerosols. The effects of sampling times (5, 10 and 20 min were also studied using the BioStage impactor when sampling environmental bioaerosols as well as aerosolized Bacillus subtilis (G+ and Escherichia coli (G-. In addition, particle bounce reduction by mineral-oil-plate was also investigated using an optical particle counter (OPC. Experimental results revealed that use of mineral-oil-spread agar plate can substantially enhance culturable bioaerosol recoveries by Andersen type impactors (p-values<0.05. The recovery enhancement was shown to depend on bioaerosol size, type, sampling time and environment. In general, more enhancements (extra 20% were observed for last stage of the Andersen six-stage samplers compared to the BioStage impactor for 10 min sampling. When sampling aerosolized B. subtilis, E. coli and environmental aerosols, the enhancement was shown to increase with increasing sampling time, ranging from 50% increase at 5 min to ∼100% at 20 min. OPC results indicated that use of mineral oil can effectively reduce the particle bounce with an average of 66% for 10 min sampling. Our work suggests that enhancements for fungal aerosols were primarily attributed to the reduced impaction stress, while for bacterial aerosols reduced impaction, desiccation and particle bounce played major roles. The developed technology can readily enhance the agar-based techniques

  4. Emission of bacterial bioaerosols from a composting facility in Maharashtra, India.

    Science.gov (United States)

    Pahari, Arnab Kumar; Dasgupta, Debdeep; Patil, Rashmi S; Mukherji, Suparna

    2016-07-01

    This study was undertaken to quantify and characterize size-segregated bacterial bioaerosols both on-site and off-site of a waste treatment facility (WTF) in Maharashtra employing windrow composting. Viable bacterial bioaerosols on nutrient agar (NA) and actinomycetes isolation agar (AIA) were quantified after sampling using Anderson-six stage impactor. Viable bacterial bioaerosols were identified based on 16S rDNA sequencing. Approximately, 16-34% of the total viable bacteria collected at the WTF were in the size range 0.65-2.1μm that can penetrate deep into the respiratory tract and also represents bacteria present in free form. Thus, 66-84% of bacterial bioaerosols were associated with coarse airborne particles greater than 2.1μm. A total of 24 bacterial species were isolated and characterized through gram staining. Among these 25% were gram negative and 75% were gram positive. The predominant bacterial genera were Bacillus, Streptococcus, Staphylococcus, Acinetobacter and Kocuria. The mean on-site concentration of total viable bacteria on NA and AIA and airborne particles (PM2.5 and PM10) were higher than the corresponding off-site values. The mean on-site concentration of viable bacteria on NA and AIA were in the range of 3.8×10(3) to 5.4×10(4)CFU/m(3) and 9.8×10(3) to 1.2×10(5)CFU/m(3), respectively, during activity period. Good correlation (R(2)=0.999) was observed between total bioaerosols and aerosols (PM10) collected using Anderson impactor and High volume sampler, respectively. Sampling size segregated aerosols using the Siotus personal cascade impactor indicated higher association of bacteria with the coarse fraction (greater than 2.5μm). PMID:27155946

  5. Bioaerosols laser-induced fluorescence provides specific robust signatures for standoff detection

    Science.gov (United States)

    Buteau, Sylvie; Simard, Jean-Robert; Déry, Bernard; Roy, Gilles; Lahaie, Pierre; Mathieu, Pierre; Ho, Jim; McFee, John

    2006-10-01

    One of today's primary security challenges is the emerging biological threat due to the increased accessibility to biological warfare technology and the limited efficiency of detection against such menace. At the end of the 90s, Defence R&D Canada developed a standoff bioaerosol sensor, SINBAHD, based on intensified range-gated spectrometric detection of Laser Induced Fluorescence (LIF) with an excitation at 351 nm. This LIDAR system generates specific spectrally wide fluorescence signals originating from inelastic interactions with complex molecules forming the building blocks of most bioaerosols. This LIF signal is spectrally collected by a combination of a dispersive element and a range-gated ICCD that limits the spectral information within a selected atmospheric cell. The system can detect and classify bioaerosols in real-time, with the help of a data exploitation process based on a least-square fit of the acquired fluorescence signal by a linear combination of normalized spectral signatures. The detection and classification processes are hence directly dependant on the accuracy of these signatures to represent the intrinsic fluorescence of bioaerosols and their discrepancy. Comparisons of spectral signatures acquired at Suffield in 2001 and at Dugway in 2005 of bioaerosol simulants, Bacillius subtilis var globiggi (BG) and Erwinia herbicola (EH), having different origin, preparation protocol and/or dissemination modes, has been made and demonstrates the robustness of the obtained spectral signatures in these particular cases. Specific spectral signatures and their minimum detectable concentrations for different simulants/interferents obtained at the Joint Biological Standoff Detection System (JBSDS) increment II field demonstration trial, Dugway Proving Ground (DPG) in June 2005, are also presented.

  6. EMI Standards for Wireless Voice and Data on Board Aircraft

    Science.gov (United States)

    Ely, Jay J.; Nguyen, Truong X.

    2002-01-01

    The use of portable electronic devices (PEDs) on board aircraft continues to be an increasing source of misunderstanding between passengers and flight-crews, and consequently, an issue of controversy between wireless product manufacturers and air transport regulatory authorities. This conflict arises primarily because of the vastly different regulatory objectives between commercial product and airborne equipment standards for avoiding electromagnetic interference (EMI). This paper summarizes international regulatory limits and test processes for measuring spurious radiated emissions from commercially available PEDs, and compares them to international standards for airborne equipment. The goal is to provide insight for wireless product developers desiring to extend the freedom of their customers to use wireless products on-board aircraft, and to identify future product characteristics, test methods and technologies that may facilitate improved wireless freedom for airline passengers.

  7. Effect of hybrid UV-thermal energy stimuli on inactivation of S. epidermidis andB. subtilis bacterial bioaerosols

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Gi Byoung; Jung, Jae Hee; Jeong, Tae Gun; Lee, Byung Uk, E-mail: leebu@konkuk.ac.kr [Aerosol and Bioengineering Laboratory, Department of Mechanical Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-Gu, Seoul, 143-701(Korea, Republic of)

    2010-11-01

    Bioaerosols have become an increasingly important issue due to their harmful effects on human health. As the concern over airborne microorganisms grows, so does the need to develop and study efficient methods of controlling them. In this study, we designed a hybrid system involving ultraviolet (UV) irradiation and thermal energy and investigated its effects on bacterial bioaerosols, followed by a comparison with thermal energy alone and UV irradiation alone. The results show that the hybrid effect caused no variation in the shape of the normalized particle size distributions of S. epidermidis and B. subtilis bioaerosols. However, a physical transport loss of bacterial bioaerosols developed as the temperature inside the glass quartz tube increased. When bacterial bioaerosols were simultaneously exposed to UV irradiation and thermal energy for less than 1.05 s, more than 99% of S. epidermidis bioaerosols were inactivated at 120 {sup o}C with exposure to one UV lamp and at 80 {sup o}C with exposure to two UV lamps; and 93.5% and 98.5% of B. subtilis bioaerosols were inactivated at 280 {sup o}C with exposure to one and two UV lamps, respectively. Moreover, the hybrid UV-thermal stimuli significantly reduced the concentration of ozone, which is a secondary UV-induced pollutant. Our results show that to obtain the same inactivation efficiency, the hybrid UV-thermal stimuli were more efficient than thermal energy alone in terms of energy consumption and produced significantly less ozone than UV irradiation alone. The hybrid stimuli also had higher inactivation efficiency than UV alone. Therefore, these results provide valuable information for the development of new methods for controlling bioaerosols.

  8. Fast monitoring of indoor bioaerosol concentrations with ATP bioluminescence assay using an electrostatic rod-type sampler.

    Directory of Open Access Journals (Sweden)

    Ji-Woon Park

    Full Text Available A culture-based colony counting method is the most widely used analytical technique for monitoring bioaerosols in both indoor and outdoor environments. However, this method requires several days for colony formation. In this study, our goal was fast monitoring (Sampling: 3 min, Detection: < 1 min of indoor bioaerosol concentrations with ATP bioluminescence assay using a bioaerosol sampler. For this purpose, a novel hand-held electrostatic rod-type sampler (110 mm wide, 115 mm long, and 200 mm tall was developed and used with a commercial luminometer, which employs the Adenosine triphosphate (ATP bioluminescence method. The sampler consisted of a wire-rod type charger and a cylindrical collector, and was operated with an applied voltage of 4.5 kV and a sampling flow rate of 150.7 lpm. Its performance was tested using Staphylococcus epidermidis which was aerosolized with an atomizer. Bioaerosol concentrations were measured using ATP bioluminescence method with our sampler and compared with the culture-based method using Andersen cascade impactor under controlled laboratory conditions. Indoor bioaerosol concentrations were also measured using both methods in various indoor environments. A linear correlation was obtained between both methods in lab-tests and field-tests. Our proposed sampler with ATP bioluminescence method may be effective for fast monitoring of indoor bioaerosol concentrations.

  9. Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

    Directory of Open Access Journals (Sweden)

    Mara E Robu

    Full Text Available Disruption of early mitotic inhibitor 1 (Emi1 interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling the accumulation of Cyclins A and B so they can regulate replication and promote the transition from G2 phase to mitosis, respectively. Depletion of Emi1 prevents mitotic entry and causes rereplication and an increase in cell size. In this study, we show that the developmental and cell cycle defects caused by inactivation of zebrafish emi1 are due to inappropriate activation of APC/C through its cofactor Cdh1. Inhibiting/slowing progression into S-phase by depleting Cdt1, an essential replication licensing factor, partially rescued emi1 deficiency-induced rereplication and the increased cell size. The cell size effect was enhanced by co-depletion of cell survival regulator p53. These data suggest that the increased size of emi1-deficient cells is either directly or indirectly caused by the rereplication defects. Moreover, enforced expression of Cyclin A partially ablated the rereplicating population in emi1-deficient zebrafish embryos, consistent with the role of Cyclin A in origin licensing. Forced expression of Cyclin B partially restored the G1 population, in agreement with the established role of Cyclin B in mitotic progression and exit. However, expression of Cyclin B also partially inhibited rereplication in emi1-deficient embryos, suggesting a role for Cyclin B in regulating replication in this cellular context. As Cyclin A and B are substrates for APC/C-Cdh1 - mediated degradation, and Cdt1 is under control of Cyclin A, these data indicate that emi1 deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.

  10. Differential Mode EMI Filter Design for Isolated DC-DC Boost Converter

    DEFF Research Database (Denmark)

    Makda, Ishtiyaq Ahmed; Nymand, Morten

    2014-01-01

    A Differential Mode EMI filter for a low input voltage high-current isolated dc-dc boost converter is designed and presented in this paper. The primary side Differential Mode noise voltage is low due to the high transformer turn ratio, however, the input current is very high and since the EMI limit...... is identified first. The DM noise model is then established and based on the harmonic analysis of the noise source voltage waveform, the complete Differential Mode EMI filter, including the filter resonance damping branch, is designed for a 3kW isolated dc-dc boost converter. The noise model and its theoretical...

  11. Report of the EMI Testing of the Johnson Noise Thermometry System

    Energy Technology Data Exchange (ETDEWEB)

    Britton Jr., Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Roberts, Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-06-01

    This report summarizes the Electromagnetic Interference (EMI) testing of the Johnson Noise Thermometry System developed at ORNL. The EMI performance is very important for Johnson Noise Thermometry because it requires accurate measurement of a very small noise signal that is amplified 10,000 times. Any interference in the form on pickup from external signal sources from such as fluorescent lighting ballasts, motors, etc. can skew the measurement. Testing is therefore very important in determining the effects of these external noise sources. Results from testing in several environments with various sources of EMI are presented here.

  12. Pars Injuries in Athletes.

    Science.gov (United States)

    Oren, Jonathan H; Gallina, Jason M

    2016-03-01

    Pars injuries are common causes of low back pain in adolescent athletes. Workup traditionally has included lumbar radiographs with oblique views and single-photon emission computed tomography (SPECT). However, recent literature has demonstrated the accuracy of MRI as a diagnostic modality. Acute injuries may be amenable to bracing with the goal of a healed lesion. Most cases of spondylolysis will result in asymptomatic non-union, though pars repair is an option for symptomatic pars defects without spondylolisthesis. PMID:26977552

  13. Characterization of ambient aerosols at the San Francisco International Airport using BioAerosol Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Steele, P T; McJimpsey, E L; Coffee, K R; Fergenson, D P; Riot, V J; Tobias, H J; Woods, B W; Gard, E E; Frank, M

    2006-03-16

    The BioAerosol Mass Spectrometry (BAMS) system is a rapidly fieldable, fully autonomous instrument that can perform correlated measurements of multiple orthogonal properties of individual aerosol particles. The BAMS front end uses optical techniques to nondestructively measure a particle's aerodynamic diameter and fluorescence properties. Fluorescence can be excited at 266nm or 355nm and is detected in two broad wavelength bands. Individual particles with appropriate size and fluorescence properties can then be analyzed more thoroughly in a dual-polarity time-of-flight mass spectrometer. Over the course of two deployments to the San Francisco International Airport, more than 6.5 million individual aerosol particles were fully analyzed by the system. Analysis of the resulting data has provided a number of important insights relevant to rapid bioaerosol detection, which are described here.

  14. Internet of Vehicles for E-Health Applications in View of EMI on Medical Sensors

    Directory of Open Access Journals (Sweden)

    Di Lin

    2015-01-01

    Full Text Available Wireless technologies are pervasive to support ubiquitous healthcare applications. However, RF transmission in wireless technologies can lead to electromagnetic interference (EMI on medical sensors under a healthcare scenario, and a high level of EMI may lead to a critical malfunction of medical sensors. In view of EMI to medical sensors, we propose a joint power and rate control algorithm under game theoretic framework to schedule data transmission at each of wireless sensors. The objective of such a game is to maximize the utility of each wireless user subject to the EMI constraints for medical sensors. We show that the proposed game has a unique Nash equilibrium and our joint power and rate control algorithm would converge to the Nash equilibrium. Numerical results illustrate that the proposed algorithm can achieve robust performance against the variations of mobile hospital environments.

  15. Respiratory Disorders Associated with Occupational Inhalational Exposure to Bioaerosols among Wastewater Treatment Workers of Petrochemical Complexes

    OpenAIRE

    Jahangiri, M; Neghab, M; G Nasiri; M Aghabeigi; V Khademian; Rostami, R.; V Kargar; J Rasooli

    2015-01-01

    Background: Workers in wastewater treatment plants are exposed to a wide range of chemicals as well as biological contaminants.Objective: To ascertain whether exposure to bio-aerosols under the normal working conditions in wastewater treatment plants is associated with any significant changes in the prevalence of respiratory symptoms and lung function capacities.Methods: 198 employees of wastewater treatment plants and 99 unexposed persons were studied. American thoracic society (ATS) standar...

  16. Bioaerosol DNA Extraction Technique from Air Filters Collected from Marine and Freshwater Locations

    Science.gov (United States)

    Beckwith, M.; Crandall, S. G.; Barnes, A.; Paytan, A.

    2015-12-01

    Bioaerosols are composed of microorganisms suspended in air. Among these organisms include bacteria, fungi, virus, and protists. Microbes introduced into the atmosphere can drift, primarily by wind, into natural environments different from their point of origin. Although bioaerosols can impact atmospheric dynamics as well as the ecology and biogeochemistry of terrestrial systems, very little is known about the composition of bioaerosols collected from marine and freshwater environments. The first step to determine composition of airborne microbes is to successfully extract environmental DNA from air filters. We asked 1) can DNA be extracted from quartz (SiO2) air filters? and 2) how can we optimize the DNA yield for downstream metagenomic sequencing? Aerosol filters were collected and archived on a weekly basis from aquatic sites (USA, Bermuda, Israel) over the course of 10 years. We successfully extracted DNA from a subsample of ~ 20 filters. We modified a DNA extraction protocol (Qiagen) by adding a beadbeating step to mechanically shear cell walls in order to optimize our DNA product. We quantified our DNA yield using a spectrophotometer (Nanodrop 1000). Results indicate that DNA can indeed be extracted from quartz filters. The additional beadbeating step helped increase our yield - up to twice as much DNA product was obtained compared to when this step was omitted. Moreover, bioaerosol DNA content does vary across time. For instance, the DNA extracted from filters from Lake Tahoe, USA collected near the end of June decreased from 9.9 ng/μL in 2007 to 3.8 ng/μL in 2008. Further next-generation sequencing analysis of our extracted DNA will be performed to determine the composition of these microbes. We will also model the meteorological and chemical factors that are good predictors for microbial composition for our samples over time and space.

  17. The contribution of bioaerosols to the organic carbon mass of the atmosphere

    Science.gov (United States)

    Myriokefalitakis, Stelios; Fanourgakis, George; Kanakidou, Maria

    2016-04-01

    The atmospheric cycle of Primary Biogenic Aerosol Particles (PBAPs) is here parameterized in a state-of-the-art global 3-D chemistry-transport model (TM4-ECPL) by taking into account their primary emissions as well as their chemical aging during the long-range transport in the atmosphere. PBAPs, commonly known also as bioaerosols, are airborne particles that can carry micro-organisms and they dominate the aerosol mass over remote forest regions. Bioaerosols include mainly bacteria, fungi spores and pollen, as well as viruses, other microorganisms, or even leaf debris. For the present study, we explicitly account for emissions of bacteria, fungi spores and pollen to the atmosphere, using different ecosystems to parameterize their respective flux rates as well as meteorological parameters to account for their seasonal variation. Changes in the solubility of bioaerosols via atmospheric oxidation during their atmospheric cycle as parameterized in the model affect their physical properties and substantially their atmospheric lifetime. Model results are compared with available observations to constrain the PBAPs contribution to the aerosol organic mass. Uncertainties are further discussed based on model simulations. This work has been supported by the European FP7 collaborative project BACCHUS (Impact of Biogenic versus Anthropogenic emissions on Clouds and Climate: towards a Holistic UnderStanding).

  18. Fully Automated Field-Deployable Bioaerosol Monitoring System Using Carbon Nanotube-Based Biosensors.

    Science.gov (United States)

    Kim, Junhyup; Jin, Joon-Hyung; Kim, Hyun Soo; Song, Wonbin; Shin, Su-Kyoung; Yi, Hana; Jang, Dae-Ho; Shin, Sehyun; Lee, Byung Yang

    2016-05-17

    Much progress has been made in the field of automated monitoring systems of airborne pathogens. However, they still lack the robustness and stability necessary for field deployment. Here, we demonstrate a bioaerosol automonitoring instrument (BAMI) specifically designed for the in situ capturing and continuous monitoring of airborne fungal particles. This was possible by developing highly sensitive and selective fungi sensors based on two-channel carbon nanotube field-effect transistors (CNT-FETs), followed by integration with a bioaerosol sampler, a Peltier cooler for receptor lifetime enhancement, and a pumping assembly for fluidic control. These four main components collectively cooperated with each other to enable the real-time monitoring of fungi. The two-channel CNT-FETs can detect two different fungal species simultaneously. The Peltier cooler effectively lowers the working temperature of the sensor device, resulting in extended sensor lifetime and receptor stability. The system performance was verified in both laboratory conditions and real residential areas. The system response was in accordance with reported fungal species distribution in the environment. Our system is versatile enough that it can be easily modified for the monitoring of other airborne pathogens. We expect that our system will expedite the development of hand-held and portable systems for airborne bioaerosol monitoring. PMID:27070239

  19. Role of preprocedural rinse and high volume evacuator in reducing bacterial contamination in bioaerosols

    Directory of Open Access Journals (Sweden)

    T V Narayana

    2016-01-01

    Methods: About 45 individuals were divided into three Groups A, B and C. These groups underwent ultrasonic scaling before and after the use of CHX (0.12%, HVE and combination of CHX (0.12% and HVE. Bioaerosols were collected on blood agar plates which were incubated at 37°C for 48 h, and the CFUs were counted with manual colony counting device. A comparison was also done between A versus B, B versus C and A versus C groups. Statistical Analysis Used: Student′s t-test. Results: We found a significant reduction in the CFUs when CHX (0.12% preprocedural rinse (P < 0, or HVE (P < 0.001 or combination of both CHX (0.12% and HVE were employed (P < 0.001. Maximum reduction in CFUs was observed when CHX (0.12% and HVE were used in combination as compared to their individual use. A moderate significance was seen between A versus C groups but not with B versus C groups and A versus B groups. Conclusion: From our study, we conclude that individual methods such as CHX (0.12% and HVE were useful to reduce the dental bioaerosols; however, combination of both CHX (0.12% and HVE is more efficient to reduce dental bioaerosols than individual method.

  20. Overwintered Hatchlings of Emys orbicularis from Lake Sülüklü (Western Anatolia, Turkey

    Directory of Open Access Journals (Sweden)

    Dinçer Ayaz

    2011-07-01

    Full Text Available During our monitoring survey of amphibians and Emys orbicularis in Lake Sülüklü (Western Anatolia, Turkey, we observed four overwintered hatchlings of European pond turtle on May 4 and 10, 2010. The average straightline maximum carapace length of the neonates captured was 26.48 mm and their average weight was 4.18 g. This observation is the second record for the Turkish population of Emys orbicularis.

  1. ABB combustion engineering's experience in EMI/RFI qualification of digital systems for safety system applications

    International Nuclear Information System (INIS)

    The presented group of diagrams outlines ABB Combustion Engineering's experience with minicomputer, PLC and microcomputer based instrumentation EMI/RFI qualification. Qualified systems include a core protection calculator system (CPCS), a diverse auxiliary FW actuation system (DAFAS), and a RPS and control system upgrade. The EMI/RFI qualification testing procedure is described. Lessons learned during the qualification of digital equipment for safety systems are listed

  2. Volatile particles formation during PartEmis: a modelling study

    Directory of Open Access Journals (Sweden)

    X. Vancassel

    2004-01-01

    Full Text Available A modelling study of the formation of volatile particles in a combustor exhaust has been carried out in the frame of the PartEmis European project. A kinetic model has been used in order to investigate nucleation efficiency of the H2O-H2SO4 binary mixture in the sampling system. A value for the fraction of the fuel sulphur S(IV converted into S(VI has been indirectly deduced from comparisons between model results and measurements. In the present study, ranges between roughly 2.5% and 6%, depending on the combustor settings and on the value assumed for the parameter describing sulphuric acid wall losses. Soot particles hygroscopicity has also been investigated as their activation is a key parameter for contrail formation. Growth factors of monodisperse particles exposed to high relative humidity (95% have been calculated and compared with experimental results. The modelling study confirms that the growth factor increases as the soot particle size decreases.

  3. Measurement of EMI at nuclear power plants during wireless communications

    International Nuclear Information System (INIS)

    Until now, we normally use communication through wire for maintenance in a nuclear power plant during a planned overhaul period or an unexpected plant stop period. But the use of wireless communication reduces working time required for maintenance than the case to use communication through wire in a power plant, so there are many advantage such as work efficiency and electric power production. And the utility has implemented digital technology into the design of the plant protection system in new nuclear power plants and also replaced existing analog instrumentation and control (I and C) systems with computer based digital I and C systems as the analog systems become obsolete. On the other hand, digital I and C systems, which provide more operating capabilities than analog systems, operate wireless communication at conditions that are more vulnerable to electromagnetic interference (EMI) than existing analog systems. This paper deals with measurement and analysis of the electric field intensity for the operation of a wireless phone at the frequency range of 2.4 GHz in the area of the main control room at Uljin nuclear power plants. Also, the results of immunity test about the equipment were installed in under condition to generate high output in a wireless phone are presented

  4. Fast monitoring of indoor bioaerosol concentrations with ATP bioluminescence assay using an electrostatic rod-type sampler.

    Science.gov (United States)

    Park, Ji-Woon; Park, Chul Woo; Lee, Sung Hwa; Hwang, Jungho

    2015-01-01

    A culture-based colony counting method is the most widely used analytical technique for monitoring bioaerosols in both indoor and outdoor environments. However, this method requires several days for colony formation. In this study, our goal was fast monitoring (Sampling: 3 min, Detection: bioluminescence assay using a bioaerosol sampler. For this purpose, a novel hand-held electrostatic rod-type sampler (110 mm wide, 115 mm long, and 200 mm tall) was developed and used with a commercial luminometer, which employs the Adenosine triphosphate (ATP) bioluminescence method. The sampler consisted of a wire-rod type charger and a cylindrical collector, and was operated with an applied voltage of 4.5 kV and a sampling flow rate of 150.7 lpm. Its performance was tested using Staphylococcus epidermidis which was aerosolized with an atomizer. Bioaerosol concentrations were measured using ATP bioluminescence method with our sampler and compared with the culture-based method using Andersen cascade impactor under controlled laboratory conditions. Indoor bioaerosol concentrations were also measured using both methods in various indoor environments. A linear correlation was obtained between both methods in lab-tests and field-tests. Our proposed sampler with ATP bioluminescence method may be effective for fast monitoring of indoor bioaerosol concentrations.

  5. Real-time monitoring of bioaerosols via cell-lysis by air ion and ATP bioluminescence detection.

    Science.gov (United States)

    Park, Chul Woo; Park, Ji-Woon; Lee, Sung Hwa; Hwang, Jungho

    2014-02-15

    In this study, we introduce a methodology for disrupting cell membranes with air ions coupled with ATP bioluminescence detection for real-time monitoring of bioaerosol concentrations. A carbon fiber ionizer was used to extract ATP from bacterial cells for generating ATP bioluminescence. Our methodology was tested using Staphylococcus epidermidis and Escherichia coli, which were aerosolized with an atomizer, and then indoor bioaerosols were also used for testing the methodology. Bioaerosol concentrations were estimated without culturing which requires several days for colony formation. Correlation equations were obtained for results acquired using our methodology (Relative Luminescent Unit (RLU)/m(3)) and a culture-based (Colony Forming Unit (CFU)/m(3)) method; CFU/m(3)=1.8 × measured RLU/m(3) for S. epidermidis and E. coli, and CFU/m(3)=1.1 × measured RLU/m(3) for indoor bioaerosols under the experimental conditions. Our methodology is an affordable solution for rapidly monitoring bioaerosols due to rapid detection time (cell-lysis time: 3 min; bioluminescence detection time: <1 min) and easy operation.

  6. [Concentration and Size Distribution of Bioaerosols in Indoor Environment of University Dormitory During the Plum Rain Period].

    Science.gov (United States)

    Liu, Ting; Li, Lu; Zhang, Jia-quan; Zhan, Chang-lin; Liu, Hong-xia; Zheng, Jing-ru; Yao, Rui-zhen; Cao, Jun-ji

    2016-04-15

    Bioaerosols of university dormitory can spread through air and cause a potential health risk for student staying in indoor environment. To quantify the characteristics of bioaerosols in indoor environment of university dormitory, concentration and size distribution of culturable bioaerosols were detected during the plum rain period, the correlations of culturable bioaerosol with concentration of particulate matter, the ambient temperature and relative humidity were analyzed using Spearman's correlation coefficient and finally the changes of size distribution of culturable bioaerosol caused by activities of students were detected. The results showed that the mean concentrations of culturable airborne bacteria and fungi were (2133 +/- 1617) CFUm' and (3111 +/- 2202) CFU x m(-3). The concentrations of culturable airborne bacteria and fungi exhibited negative correlation with PM1, PM2.5, and PM10, respectively. The respirable fractions of bacteria exhibited positive correlation with PM2.5, and the respirable fractions of fungi exhibited significant positive correlation with PM10. Ambient temperature had positive correlation with culturable airborne bacteria and fungi, and relative humidity had negative correlation with culturable airborne bacteria and fungi. In the afternoon, concentrations of culturable airborne fungi in indoor environment of university dormitory significantly increased, and the size distribution of culturable hioaerosols was different in the morning and afternoon. PMID:27548944

  7. Par Pond water balance

    International Nuclear Information System (INIS)

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  8. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian;

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...

  9. Active implantable medical device EMI assessment for wireless power transfer operating in LF and HF bands

    Science.gov (United States)

    Hikage, Takashi; Nojima, Toshio; Fujimoto, Hiroshi

    2016-06-01

    The electromagnetic interference (EMI) imposed on active implantable medical devices by wireless power transfer systems (WPTSs) is discussed based upon results of in vitro experiments. The purpose of this study is to present comprehensive EMI test results gathered from implantable-cardiac pacemakers and implantable cardioverter defibrillators exposed to the electromagnetic field generated by several WPTSs operating in low-frequency (70 kHz–460 kHz) and high-frequency (6.78 MHz) bands. The constructed in vitro experimental test system based upon an Irnich’s flat torso phantom was applied. EMI test experiments are conducted on 14 types of WPTSs including Qi-compliant system and EV-charging WPT system mounted on current production EVs. In addition, a numerical simulation model for active implantable medical device (AIMD) EMI estimation based on the experimental test system is newly proposed. The experimental results demonstrate the risk of WPTSs emitting intermittent signal to affect the correct behavior of AIMDs when operating at very short distances. The proposed numerical simulation model is applicable to obtain basically the EMI characteristics of various types of WPTSs.

  10. Active implantable medical device EMI assessment for wireless power transfer operating in LF and HF bands.

    Science.gov (United States)

    Hikage, Takashi; Nojima, Toshio; Fujimoto, Hiroshi

    2016-06-21

    The electromagnetic interference (EMI) imposed on active implantable medical devices by wireless power transfer systems (WPTSs) is discussed based upon results of in vitro experiments. The purpose of this study is to present comprehensive EMI test results gathered from implantable-cardiac pacemakers and implantable cardioverter defibrillators exposed to the electromagnetic field generated by several WPTSs operating in low-frequency (70 kHz-460 kHz) and high-frequency (6.78 MHz) bands. The constructed in vitro experimental test system based upon an Irnich's flat torso phantom was applied. EMI test experiments are conducted on 14 types of WPTSs including Qi-compliant system and EV-charging WPT system mounted on current production EVs. In addition, a numerical simulation model for active implantable medical device (AIMD) EMI estimation based on the experimental test system is newly proposed. The experimental results demonstrate the risk of WPTSs emitting intermittent signal to affect the correct behavior of AIMDs when operating at very short distances. The proposed numerical simulation model is applicable to obtain basically the EMI characteristics of various types of WPTSs. PMID:27224201

  11. Toxicity of effluents emitted by the diesel engines vehicles; Toxicite des effluents emis par les vehicules a moteur diesel

    Energy Technology Data Exchange (ETDEWEB)

    Alcon, St.

    1998-04-29

    The exhaust gases of diesel engine vehicles are atmospheric pollutants. They are characterised by a gaseous phase and a particulate phase. The diesel particulates are composed of a nucleus formed with elementary carbon, forming aggregates that absorb the organic by-products at their surface. A first part treats the effluents of diesel engine vehicles: their characteristics, the factors influencing the diesel emissions, the noxiousness of the gaseous phase, the kinetics and the metabolism of the particulate phase and analysis methods. A second part tackles the experimental toxicity of diesel effluents on insisting on the nature of exposures, the mutagenicity, the carcinogenicity, the effects on the reproduction function and immuno-toxicity. A third part is devoted to the toxicity for man with epidemiology data and some studies under controlled exposures. Then, a fourth part, explains the toxicity mechanisms and the action modes of diesel effluents on the carcinogen effects and on respiratory diseases. (N.C.)

  12. Indoor and outdoor bioaerosol levels at recreation facilities, elementary schools, and homes.

    Science.gov (United States)

    Jo, Wan-Kuen; Seo, Young-Jun

    2005-12-01

    One major deficiency in linking environmental exposure to health effects is the current lack of data on environmental exposure. Therefore, to address this issue, the present study measured the bacterial and fungal concentrations in the indoor and outdoor air from two types of recreation facility (42 bars and 41 Internet cafes), 44 classrooms at 11 elementary schools, and 20 homes under uncontrolled environmental conditions during both summer and winter. No major environmental problems were reported at the four microenvironments being investigated during the entire study period. Bacteria and fungi were found in all the air samples, and the environmental occurrence of individual fungi was in the order of Cladosprium, Penicillium, Aspergillus, and Alternaria. The six parameters surveyed in the present study were all found to influence the indoor and outdoor bioaerosol levels: microenvironment type, sampling time in elementary school classrooms, agar type for measuring the fungal species, seasonal variation, facility location, and summer survey periods. The indoor and outdoor air concentrations of bacteria and fungi found in this study were comparable to those in other reports, with GM values for the total bacteria and total fungi between 10 and 10(3) colony-forming units per cubic meter of air (CFU m(-3)). The fungal concentrations found at most of the indoor environments fell within the specified guidelines of the American Conference of Government Industrial Hygienists (ACGIH), between 100 and 1000 CFU m(-3) for the total fungi. However, the indoor bioaerosol concentrations at most of the surveyed environments exceeded the Korean indoor bioaerosol guideline (800 CFU m(-3)). Consequently, the current findings suggest the need for reducing strategy for indoor microorganisms at the surveyed microenvironments. PMID:15982704

  13. Ambient bioaerosol particle dynamics observed during haze and sunny days in Beijing.

    Science.gov (United States)

    Wei, Kai; Zou, Zhuanglei; Zheng, Yunhao; Li, Jing; Shen, Fangxia; Wu, Chang-Yu; Wu, Yusheng; Hu, Min; Yao, Maosheng

    2016-04-15

    The chemical characteristics of airborne particulate matter (PM) have been extensively studied; however, little information exists for its biological components (bioaerosol) especially during a haze event in mega cities. Herein, we studied the bioaerosol (fluorescent particle) dynamics on both haze and sunny days in Beijing from Dec. 2013 to March 2014 by employing a widely used real-time bioaerosol sensor-ultraviolet aerodynamic particle spectrometer (UV-APS). Firstly, we studied the fluorescent particle (BioPM) concentration and size distributions during three independent haze and three independent sunny days. Secondly, we investigated BioPM dynamics over a two-week long monitoring period which included consecutive haze days and alternated sunny days. In addition, we analyzed bacterial community structures and endotoxin levels in the air samples using pyrosequencing and Limulus amebocyte lysate (LAL) method, respectively. More than 6-fold higher fluorescent particle concentrations up to 5×10(5)/m(3) with peaks at night or early dawn were detected at the time of haze occurrences than those observed on sunny days. When the haze episode progressed for 3-5days, the BioPM concentrations were observed to decrease to the levels that were typically observed on sunny days. In general, ozone levels were found to be elevated at noon, while BioPM, NOx and relative humidity were reduced. Gene sequence analysis revealed no significant difference in abundances and community structures for top 13 bacterial genera between haze and sunny days, yet about twice higher endotoxin levels (12.4EU/m(3)) were detected on haze days than on sunny days. The results here facilitate a better understanding of atmospheric fluorescent particle dynamics including those under haze events. PMID:26849339

  14. Ambient bioaerosol particle dynamics observed during haze and sunny days in Beijing.

    Science.gov (United States)

    Wei, Kai; Zou, Zhuanglei; Zheng, Yunhao; Li, Jing; Shen, Fangxia; Wu, Chang-Yu; Wu, Yusheng; Hu, Min; Yao, Maosheng

    2016-04-15

    The chemical characteristics of airborne particulate matter (PM) have been extensively studied; however, little information exists for its biological components (bioaerosol) especially during a haze event in mega cities. Herein, we studied the bioaerosol (fluorescent particle) dynamics on both haze and sunny days in Beijing from Dec. 2013 to March 2014 by employing a widely used real-time bioaerosol sensor-ultraviolet aerodynamic particle spectrometer (UV-APS). Firstly, we studied the fluorescent particle (BioPM) concentration and size distributions during three independent haze and three independent sunny days. Secondly, we investigated BioPM dynamics over a two-week long monitoring period which included consecutive haze days and alternated sunny days. In addition, we analyzed bacterial community structures and endotoxin levels in the air samples using pyrosequencing and Limulus amebocyte lysate (LAL) method, respectively. More than 6-fold higher fluorescent particle concentrations up to 5×10(5)/m(3) with peaks at night or early dawn were detected at the time of haze occurrences than those observed on sunny days. When the haze episode progressed for 3-5days, the BioPM concentrations were observed to decrease to the levels that were typically observed on sunny days. In general, ozone levels were found to be elevated at noon, while BioPM, NOx and relative humidity were reduced. Gene sequence analysis revealed no significant difference in abundances and community structures for top 13 bacterial genera between haze and sunny days, yet about twice higher endotoxin levels (12.4EU/m(3)) were detected on haze days than on sunny days. The results here facilitate a better understanding of atmospheric fluorescent particle dynamics including those under haze events.

  15. Bioaerosol emission rate and plume characteristics during land application of liquid class B biosolids.

    Science.gov (United States)

    Tanner, Benjamin D; Brooks, John P; Haas, Charles N; Gerba, Charles P; Pepper, Ian L

    2005-03-15

    This study investigated bioaerosol emission rates and plume characteristics of bioaerosols generated during land application of liquid Class B biosolids. In addition, it compared the rate of aerosolization of coliphages and total coliform bacteria during land application of liquid Class B biosolids to the rate of aerosolization during land application of groundwater inoculated with similar concentrations of Escherichia coli and coliphage MS2. Air samples were taken immediately downwind of a spray applicator as it applied liquid (approximately 8% solids) biosolids to farmland near Tucson, Arizona. Air samples were also collected immediately downwind of groundwater seeded with MS2 and E. coli applied to land in an identical manner. Air samples, collected with liquid impingers, were taken in horizontal and vertical alignment with respect to the passing spray applicator. Vertical and horizontal sample arrays made it possible to calculate the flux of microorganisms through a virtual plane of air samplers, located 2 m downwind of the passing spray applicator. Neither coliphages nor coliform bacteria were detected in air downwind of spray application of liquid Class B biosolids. Based on limits of detection for the methodology, the rate of aerosolization during land application of liquid biosolids was calculated to be less than 33 plaque forming units (PFU) of coliphage and 10 colony forming units (CFU) of coliform bacteria per meter traveled by the spray applicator. The rate of aerosolization during land application of seeded groundwater was found to be, on average, 2.02 x 10(3) CFU E. coli and 3.86 x 10(3) PFU MS2 aerosolized per meter traveled by the spray applicator. This is greater aerosolization than was observed during land application of biosolids. Because concentrations of coliphages and coliforms were similar in the liquid biosolids and the seeded water, itwas concluded that some property of biosolids reduces aerosolization of microorganisms relative to

  16. Sampling of high amounts of bioaerosols using a high-volume electrostatic field sampler

    DEFF Research Database (Denmark)

    Madsen, A. M.; Sharma, Anoop Kumar

    2008-01-01

    sampler for collection of fine particles has been described. The aim of this study was to investigate whether this sampler can be used for collection of high amounts of authentic bioaerosols that can subsequently be used for biological analysis. The investigation was carried out at a biofuel plant...... the same season by a factor smaller than four. The quantities of some microbial components were higher in the dust collected with all samplers in March than in August. In conclusion, by using the electrostatic field sampler, it was possible to sample replicas of large authentic aerosol samples that can...

  17. An emission inventory of livestock-related bioaerosols for Lower Saxony, Germany

    Science.gov (United States)

    Seedorf, Jens

    Detailed livestock-related emission inventories are now available for gases but not for bioaerosols, which are emitted in significant amounts and in varying compositions. In view of the environmental importance of bioaerosols, a model for their calculation is proposed here. The basic formula multiplies emission factors by the number of farm animals, but the model is extended by a factor which considers provisionally the influence of production cycles of various types of livestock on the estimated emissions. Despite several uncertainty factors, emissions factors are calculated for dust (inhalable, respirable), endotoxins (inhalable, respirable) and microorganisms (total mesophilic bacteria, Enterobacteriaceae, fungi) from ventilated livestock buildings. The calculation model and the emission factors are the basis for a simple geographical information system designed to display the calculated emission potencies of livestock-related bioaerosols for the year 1999 in the 46 districts and autonomous cities in Lower Saxony, Germany. The three highest emissions of inhalable dust were determined for the three animal-dense districts of Grafschaft Bentheim (485.3 kg a -1 km -2), Cloppenburg (648.8 kg a -1 km -2) and Vechta (1203.4 kg a -1 km -2). On the other hand, the lowest bioaerosol emissions were found for the cities of Salzgitter (9.6 kg a -1 km -2), Braunschweig (10.6 kg a -1 km -2) and Wolfenbüttel (12.2 kg a -1 km -2) due to their more urban, non-agricultural setting. With the aid of the agricultural census data, the percentages of temporal emission variations were assessed between 1996 and 1999, and found to have changed distinctly due to fluctuations in animal numbers in the districts. The following changes were noted in the three districts with the greatest increase or decrease of emitted particulate matter from 1996 to 1999: more inhalable dust was emitted in the rural districts of Stade (+9.6%), Cloppenburg (+14.9%) and Emsland (+18.2%), while there were clear

  18. Controlling DC-DC converters by chaos-based pulse width modulation to reduce EMI

    Energy Technology Data Exchange (ETDEWEB)

    Li Hong [Department of Mathematics and Computer Science, FernUniversitaet in Hagen, 58084 Hagen (Germany)], E-mail: hong.li@FernUni-Hagen.de; Zhang Bo [School of Electric Power, South China University of Technology, Guangzhou (China); Li Zhong; Halang, Wolfgang A. [Department of Mathematics and Computer Science, FernUniversitaet in Hagen, 58084 Hagen (Germany); Chen Guanrong [Department of Electronic Engineering, City University of Hong Kong, Hong Kong (China)

    2009-11-15

    In this paper, periodic and chaotic behaviors of DC-DC converters under certain parametric conditions are simulated, experimentally verified, and analyzed. Motivated by the work of J.H.B. Deane and D.C. Hamill in 1996, where chaotic phenomena are useful in suppressing electromagnetic interference (EMI) by adjusting the parameters of the DC-DC converter and making it operate in chaos, a chaos-based pulse width modulation (CPWM) is proposed to distribute the harmonics of the DC-DC converters continuously and evenly over a wide frequency range, thereby reducing the EMI. The output waves and spectral properties of the EMI are simulated and analyzed as the carrier frequency or amplitude changes with regard to different chaotic maps. Simulation and experimental results are given to illustrate the effectiveness of the proposed CPWM, which provides a good example of applying chaos theory in engineering practice.

  19. Electromagnetic interference (EMI) shielding of ordered mesoporous carbon (OMC)/paraffin composites.

    Science.gov (United States)

    Wu, Hongjing; Wang, Liuding; Zhang, Jiangdong; Wei, Gao; Guo, Shaoli; Shen, Zhongyuan

    2014-08-01

    The ordered mesoporous carbon (OMC)/paraffin composites were successfully prepared by a facile physical mixing method and an EMI SE of 21-23 dB was achieved at the OMC loading of 5.69 wt.% in the X band. This indicates that the composites are very suitable for an application as effective and lightweight EMI shielding materials. The EMI shielding of the composite shows an absorption-dominant mechanism, i.e., a contribution shift from reflection to absorption is observed with the increase in OMC loading and frequency. This could be explained by the intrinsic properties (electrical conductivity, complex permittivity and potential large defects) and novel structure of the composites. PMID:25936048

  20. Polyaniline-lead titanate composites for humidity sensing and EMI shielding applications

    Science.gov (United States)

    Manocha, Aarushi; Thomas, Jocelyn T.; Fathima, Hana; V, Suveetha; Faisal, Muhammad

    2015-06-01

    The present paper reports the humidity sensing and electromagnetic interference (EMI) shielding properties of synthesized polyaniline-lead titanate (PANi/PbTiO3) composites. The humidity sensing of the PAni/PbTiO3 composites was discussed in terms of change in direct current (DC) resistance with respect to percentage relative humidity (% RH) ranging from 20% to 90%. The EMI shielding properties of the composites were measured in the frequency range of 8-12 GHz (X-band), relevant for practical applications. The composites showed shielding effectiveness (SE) in the range -29 dB to -34 dB and the variations in the shielding effectiveness with the frequency was minimal at a fixed composition. The observed effective humidity sensing and EMI shielding properties highlights the prospects of multifunctional applications of these composites.

  1. Performance Study of CM/DM Discrimination Network for Conducted EMI Diagnosis

    Institute of Scientific and Technical Information of China (English)

    ZHAOYang; SEEKyeYak

    2003-01-01

    This paper compares the discrimination capability for four different types of Common-mode and Differential-mode Discrimination networks (CM/DM DN). The insertion losses and mode rejection performances for the four CM/DM DNs are measured. Based on the measured results, the CM/DM DN with the best discrimination capability is chosen for the purpose of conducted EMI diagnosis. A practical example is shown to demonstrate the ease of EMI diagnosis, with the aid of the chosen CM/DM DN.

  2. Copper plating on the polyimide film by electroless plating techniques for EMI shielding.

    Science.gov (United States)

    Ji, Eun Sun; Cha, Hyun Gil; Kim, Chang Woo; Kang, Dong In; Kang, Young Soo

    2009-12-01

    In this work, the metal plated film was prepared by electroless plating techniques. The film was prepared for the fabrication of EMI shielding. Polyimide film was treated by base solution for etching and then activated by silver. The modified polyimide film was immersed into the electroless copper plating solution which has different molar ratios of nickel in the solution. The thickness and surface morphology of copper layer on the polyimide films were characterized with scanning electron microscopy (SEM). Furthermore, EMI shielding ability of the film was calculated by measuring reflectivity of EM wave on the film surface using the equation of Schelkunoff theory. PMID:19908729

  3. EMI suppression of klystron pulse power supply for XFEL/SPring-8

    International Nuclear Information System (INIS)

    The klystron modulator power source of XFEL/SPring-8 is requested the low electro-magnetic interference (EMI), in order to realize the high stable beam by the feedback loops of high-precision beam monitors. We suppressed the EMI-noise by monocoque structure of the solid iron chassis, the eliminating the DC core bias circuit for the pulse transformer, and the co-axial pare noise filter. To estimate the effect of the noise filter, we measured the conducted noise on the heater power line. The thyratron noise was suppressed to about 10Vpk-pk, and would not interfere to the beam monitor. (author)

  4. A Simple Differential Mode EMI Suppressor for the LLCL-Filter-Based Single-Phase Grid-Tied Transformerless Inverter

    DEFF Research Database (Denmark)

    Ji, Junhao; Wu, Weimin; He, Yuanbin;

    2015-01-01

    to achieve a small value of capacitor as well as to minimize the additional reactive power, a novel simple DM EMI suppressor for the LLCL-filter-based system is proposed. The characters of two kinds of DM EMI suppressor are analyzed and compared in detail. Simulations and experiments on a 0.5-kW 110-V/50-Hz...

  5. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  6. Assessment of electrical charge on airborne microorganisms by a new bioaerosol sampling method.

    Science.gov (United States)

    Lee, Shu-An; Willeke, Klaus; Mainelis, Gediminas; Adhikari, Atin; Wang, Hongxia; Reponen, Tiina; Grinshpun, Sergey A

    2004-03-01

    Bioaerosol sampling is necessary to monitor and control human exposure to harmful airborne microorganisms. An important parameter affecting the collection of airborne microorganisms is the electrical charge on the microorganisms. Using a new design of an electrostatic precipitator (ESP) for bioaerosol sampling, the polarity and relative strength of the electrical charges on airborne microorganisms were determined in several laboratory and field environments by measuring the overall physical collection efficiency and the biological collection efficiency at specific precipitation voltages and polarities. First, bacteria, fungal spores, and dust dispersed from soiled carpets were sampled in a walk-in test chamber. Second, a simulant of anthrax-causing Bacillus anthracis spores was dispersed and sampled in the same chamber. Third, bacteria were sampled in a small office while four adults were engaged in lively discussions. Fourth, bacteria and fungal spores released from hay and horse manure were sampled in a horse barn during cleanup operations. Fifth, bacteria in metalworking fluid droplets were sampled in a metalworking simulator. It was found that the new ESP differentiates between positively and negatively charged microorganisms, and that in most of the tested environments the airborne microorganisms had a net negative charge. This adds a signature to the sampled microorganisms that may assist in their identification or differentiation, for example, in an anti-bioterrorism network.

  7. Detection and phylogenetic analysis of coastal bioaerosols using culture dependent and independent techniques

    Science.gov (United States)

    Urbano, R.; Palenik, B.; Gaston, C. J.; Prather, K. A.

    2011-02-01

    Bioaerosols are emerging as important yet poorly understood players in atmospheric processes. Microorganisms can impact atmospheric chemistry through metabolic reactions and can potentially influence physical processes by participating in ice nucleation and cloud droplet formation. Microbial roles in atmospheric processes are thought to be species-specific and potentially dependent on cell viability. Using a coastal pier monitoring site as a sampling platform, culture-dependent (i.e. agar plates) and culture-independent (i.e. DNA clone libraries from filters) approaches were combined with 18S rRNA and 16S rRNA gene targeting to obtain insight into the local atmospheric microbial composition. From 13 microbial isolates and 42 DNA library clones, a total of 55 sequences were obtained representing four independent sampling events. Sequence analysis revealed that in these coastal samples two fungal phyla, Ascomycota and Basidiomycota, predominate among eukaryotes while Firmicutes and Proteobacteria predominate among bacteria. Furthermore, our culture-dependent study verifies the viability of microbes from all four phyla detected through our culture-independent study. Contrary to our expectations and despite oceanic air mass sources, common marine planktonic bacteria and phytoplankton were not typically found. The abundance of terrestrial and marine sediment-associated microorganisms suggests a potential importance for bioaerosols derived from beaches and/or coastal erosion processes.

  8. Statistical characterisation of bio-aerosol background in an urban environment

    CERN Document Server

    Jamriska, Milan; Skvortsov, Alex

    2011-01-01

    In this paper we statistically characterise the bio-aerosol background in an urban environment. To do this we measure concentration levels of naturally occurring microbiological material in the atmosphere over a two month period. Naturally occurring bioaerosols can be considered as noise, as they mask the presence of signals coming from biological material of interest (such as an intentionally released biological agent). Analysis of this 'biobackground' was undertaken in the 1-10 um size range and a 3-9% contribution was found to be biological in origin - values which are in good agreement with other studies reported in the literature. A model based on the physics of turbulent mixing and dispersion was developed and validated against this analysis. The Gamma distribution (the basis of our model) is shown to comply with the scaling laws of the concentration moments of our data, which enables us to universally characterise both biological and non-biological material in the atmosphere. An application of this mod...

  9. Bioaerosol standoff detection and correlation assessment with concentration and viability point sensors

    Science.gov (United States)

    Buteau, Sylvie; Simard, Jean-Robert; Rowsell, Susan; Roy, Gilles

    2010-10-01

    A standoff bioaerosol sensor based on intensified range-gated spectrometric detection of Laser Induced Fluorescence was used to spectrally characterize bioaerosol simulants during in-chamber and open-air releases at Suffield, Canada, in August 2008 from a standoff position. In total, 42 in-chamber Bacillus atrophaeus (formerly Bacillus subtilis var globigii; BG) cloud and 27 open-air releases of either BG, Pantoea agglomerans (formerly Erwinia herbicola; EH), MS2 and ovalbumin (OV) were generated. The clouds were refereed by different point sensors including Aerodynamic Particle Sizer (APS) and slit or impingers samplers. The APS monitored the particle size distribution and concentration and the samplers characterized the viable portion of the cloud. The extracted spectral signatures show robustness to different degree. The correlation assessment showed good results in most cases where the LIF signal to noise ratio was significant. The sensor 4σ sensitivity was evaluated to 1 300, 600, 100 and 30 ppl for BG, OV, MS2 and EH respectively. Correlation results are presented by plotting the SINBAHD metric versus the corresponding particle concentration, in which case, the obtained slope is proportional to the material fluorescence cross-section. The different acquired signal is hence compared in terms of their fluorescence cross-section additionally to their spectral characteristics.

  10. Detection and phylogenetic analysis of coastal bioaerosols using culture dependent and independent techniques

    Directory of Open Access Journals (Sweden)

    R. Urbano

    2011-02-01

    Full Text Available Bioaerosols are emerging as important yet poorly understood players in atmospheric processes. Microorganisms can impact atmospheric chemistry through metabolic reactions and can potentially influence physical processes by participating in ice nucleation and cloud droplet formation. Microbial roles in atmospheric processes are thought to be species-specific and potentially dependent on cell viability. Using a coastal pier monitoring site as a sampling platform, culture-dependent (i.e. agar plates and culture-independent (i.e. DNA clone libraries from filters approaches were combined with 18S rRNA and 16S rRNA gene targeting to obtain insight into the local atmospheric microbial composition. From 13 microbial isolates and 42 DNA library clones, a total of 55 sequences were obtained representing four independent sampling events. Sequence analysis revealed that in these coastal samples two fungal phyla, Ascomycota and Basidiomycota, predominate among eukaryotes while Firmicutes and Proteobacteria predominate among bacteria. Furthermore, our culture-dependent study verifies the viability of microbes from all four phyla detected through our culture-independent study. Contrary to our expectations and despite oceanic air mass sources, common marine planktonic bacteria and phytoplankton were not typically found. The abundance of terrestrial and marine sediment-associated microorganisms suggests a potential importance for bioaerosols derived from beaches and/or coastal erosion processes.

  11. Understanding and mitigating the challenge of bioaerosol emissions from urban community composting

    Science.gov (United States)

    Pankhurst, L. J.; Akeel, U.; Hewson, C.; Maduka, I.; Pham, P.; Saragossi, J.; Taylor, J.; Lai, K. M.

    2011-01-01

    Within the UK, local and regional government drives to reduce the quantity of waste being sent to landfill have led to an increase in small-scale composting schemes, instigated by local councils and not-for-profit organisations. The composting process relies upon the proliferation of microorganisms, leading to their emission into the ambient environment. In this investigative study, total bacteria and Aspergillus fumigatus emitted from a small-scale composting facility in central London were measured in different spatial and temporal dimensions. Bioaerosols did not disperse in concentrations significantly higher than those measured at 'background' locations, where maximum geometric mean was 55 × 10 2 Colony Forming Units (CFU) per m -3. Concentrations on-site and at the nearest potential receptor were comparable to those found at commercial facilities, reaching 25 × 10 4 and 29 × 10 3 CFU m -3 for total bacteria and A. fumigatus respectively. The room housing the facility was contaminated by moulds; likely to result from high relative humidity of the air (consistently above 80% during this study), building material, and the generation of organic dust. The complex diurnal meteorological variations of urban environments are likely to influence bioaerosol dispersal, and consequent exposure risk for sensitive receptors. Site planning tools including Geographical Information Systems (GIS) mapping with buffer zones around schools and hospitals, and use of computerised models for the design of rooms housing urban composting facilities are proposed as methods for reducing the risk of occupational and off-site receptor exposure.

  12. Molecular characterization of microbial communities in bioaerosols of a coal mine by 454 pyrosequencing and real-time PCR.

    Science.gov (United States)

    Wei, Min; Yu, Zhisheng; Zhang, Hongxun

    2015-04-01

    Microbial diversity and abundance in bioaerosols of a coal mine were analyzed based on 454 pyrosequencing and real-time polymerase chain reaction (PCR). A total of 37,191 high quality sequences were obtained and could be classified into 531, 1730 and 448 operational taxonomic units respectively for archaea, bacteria and fungi at 97% sequence similarity. The Shannon diversity index for archaea, bacteria and fungi was respectively 4.71, 6.29 and 3.86, indicating a high diversity in coal mine bioaerosols. Crenarchaeota, Proteobacteria and Ascomycota were the dominant phyla for archaea, bacteria and fungi, respectively. The concentrations of total archaea, bacteria and fungi were 1.44×10(8), 1.02×10(8) and 9.60×10(4) cells/m3, respectively. Methanotrophs observed in bioaerosols suggested possible methane oxidation in the coal mine. The identified potential pathogens to coal miners, such as Acinetobacter schindleri, Aeromonas cavernicola, Alternaria alternata, Aspergillus penicillioides, Cladosporium cladosporioides, and Penicillium brevicompactum were also observed. This was the first investigation of microbial diversity and abundance in coal mine bioaerosols. The investigation of microbial communities would be favorable in promoting the progress of methane control based on microbial technique and concern on coal miners' health. PMID:25872733

  13. Effects of waste treatment technique and quality of waste on bioaerosols in Finnish waste treatment plants

    Energy Technology Data Exchange (ETDEWEB)

    Tolvanen, O.

    2004-07-01

    The last fifteen years have seen immense changes in waste treatment in Finland. The number of landfill sites has been reduced and new waste treatment plants have been constructed; source separation of the various waste fractions has been become increasingly effective. At the same time, considerable attention has been paid to environmental factors such as odour problems. Another important factor at waste treatment plants is the working conditions of employees. Earlier, there were numerous problems with occupational hygiene in sewage treatment plants and landfills. The present study was undertaken to determine whether serious problems with bioaerosols still exist now that there are new waste treatment techniques and waste is sorted. The concentrations of dust, microbes and endotoxins were investigated at one windrow composting site in 1993-1994 and at eight waste treatment plants in 1998-2003. The best environment in regard to occupational hygiene was the combined drum and tunnel composting plant in Heinola. The most problematic area in the plant was the storage room (tunnel) for compost, but the concentrations of bioaerosols were low even there. At the composting plant in Hyvinkaeae, where the same kind of technique was in use, there were problems with bioaerosols in all working areas investigated. The same problems were encountered in dirty working areas in a drum composting plant in Oulu; in the control room number of bioaerosols was low. Conditions were worst in the dry waste treatment plant in Tampere, where viable microbes were a particular problem in the processing hall. As well, the concentrations of dust and endotoxin were occasionally increased to a level harmful to human health. The dry waste was most affected with microbes, while the treatment of wood waste caused problems with dust. In the other plants of the study, sorting and crushing of waste caused the highest concentrations of bioaerosols. The two most common air-borne fungi at every plant were

  14. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    , results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  15. Foam injection molding of polypropylene/stainless steel fiber composites for efficient EMI shielding

    Science.gov (United States)

    Ameli, A.; Nofar, M.; Saniei, M.; Wang, S.; Park, C. B.

    2016-03-01

    Lightweight polypropylene/stainless-steel fiber (PP-SSF) composites with 15-35% density reduction were fabricated using foam injection molding and supercritical carbon dioxide (CO2). The electrical percolation threshold, through-plane electrical conductivity, and electromagnetic interference (EMI) shielding effectiveness (SE) of the PP-SSF composite foams were characterized and compared against the solid samples. The effects of the plasticizing gas and the void fraction on fiber breakage and orientation were also investigated. Microstructure characterization showed that the presence of dissolved CO2 decreased fiber breakage by about 30%, and together with foaming action, contributed to less preferential orientation of fibers. Consequently, the percolation threshold decreased up to four folds from 0.85 to 0.21 vol.% as the void fraction increased from 0 to 35%. The specific EMI SE was also significantly enhanced. A maximum specific EMI SE of 75 dB.g-1cm3 was achieved in PP-1.1 vol.% SSF composite foams, which was highly superior to 38 dB.g-1cm3 of the solid PP-1.0 vol.% SSF composites. The results reveal that light and efficient products with a lower fiber content can be developed by foam for EMI shielding applications.

  16. Comparison of three different Modulators for Power Converters with Respect to EMI Optimization

    DEFF Research Database (Denmark)

    Knott, Arnold; Pfaffinger, Gerhard; Andersen, Michael Andreas E.

    2008-01-01

    Switch-mode Power Converters are well known for emissions in the band of electromagnetic interference (EMI) interest. The spectrum shape depends on the type of modulator and its purpose. This paper gives design guidelines to choose the optimum topology depending on requirements of different appli...

  17. Conduction Losses and Common Mode EMI Analysis on Bridgeless Power Factor Correction

    DEFF Research Database (Denmark)

    Li, Qingnan; Andersen, Michael Andreas E.; Thomsen, Ole Cornelius

    2009-01-01

    In this paper, a review of Bridgeless Boost power factor correction (PFC) converters is presented at first. Performance comparison on conduction losses and common mode electromagnetic interference (EMI) are analyzed between conventional Boost PFC converter and members of Bridgeless PFC family...

  18. A confirmatory research approach to the measurement of EMI/RFI in commercial nuclear power plants

    International Nuclear Information System (INIS)

    The Oak Ridge National Laboratory (ORNL) is conducting confirmatory research on the measurement of electromagnetic/radio frequency interference (EMI/RFI) in nuclear power plants. While it makes a good beginning, the currently available research data are not sufficient to characterize the EMI/RFI environment of the typical nuclear plant. Data collected over several weeks at each of several observation points are required to meet this need. To collect the required data, several approaches are examined, the most promising of which is the relatively new technology of application specific spectral receivers. While several spectral receiver designs have been described in the literature, none is well suited for nuclear power plant EMI/RFI surveys. This paper describes the development of two receivers specifically designed for nuclear power plant EMI/RFI surveys. One receiver surveys electric fields between 5 MHz and 8 GHz, while the other surveys magnetic fields between 305 Hz and 5 MHz. The results of field tests at TVA's Bull Run Fossil Plant are reported

  19. A confirmatory research approach to the measurement of EMI/RFI in commercial nuclear power plants

    International Nuclear Information System (INIS)

    The Oak Ridge National Laboratory (ORNL) is conducting confirmatory research on the measurement of electromagnetic/radio frequency interference (EMI/RFI) in nuclear power plants while it makes a good beginning, the currently available research data are not sufficient to characterize the EMI/RFI environment of the typical nuclear plant. Data collected over several weeks at each of several observation points are required to meet this need. To collect the required data, several approaches are examined, the most promising of which is the relatively new technology of application specific spectral receivers. While several spectral receiver designs have been described in the literature, none is well suited for nuclear power plant EMI/RFI surveys. This paper describes the development of two receivers specifically designed for nuclear power plant EMI/RFI surveys. One receiver surveys electric fields between 5 MHz and 8 GHz, while the other surveys magnetic fields between 305 Hz and 5 MHz. The results of field tests at TVA's Bull Run Fossil Plant are reported

  20. Compressible Graphene-Coated Polymer Foams with Ultralow Density for Adjustable Electromagnetic Interference (EMI) Shielding.

    Science.gov (United States)

    Shen, Bin; Li, Yang; Zhai, Wentao; Zheng, Wenge

    2016-03-01

    The fabrication of low-density and compressible polymer/graphene composite (PGC) foams for adjustable electromagnetic interference (EMI) shielding remains a daunting challenge. Herein, ultralightweight and compressible PGC foams have been developed by simple solution dip-coating of graphene on commercial polyurethane (PU) sponges with highly porous network structure. The resultant PU/graphene (PUG) foams had a density as low as ∼0.027-0.030 g/cm(3) and possessed good comprehensive EMI shielding performance together with an absorption-dominant mechanism, possibly due to both conductive dissipation and multiple reflections and scattering of EM waves by the inside 3D conductive graphene network. Moreover, by taking advantage of their remarkable compressibility, the shielding performance of the PUG foams could be simply adjusted through a simple mechanical compression, showing promise for adjustable EMI shielding. We believe that the strategy for fabricating PGC foams through a simple dip-coating method could potentially promote the large-scale production of lightweight foam materials for EMI shielding. PMID:26974443

  1. A confirmatory research approach to the measurement of EMI/RFI in commercial nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kercel, S.W. [Oak Ridge National Lab., TN (United States)

    1995-04-01

    The Oak Ridge National Laboratory (ORNL) is conducting confirmatory research on the measurement of electromagnetic/radio frequency interference (EMI/RFI) in nuclear power plants. While it makes a good beginning, the currently available research data are not sufficient to characterize the EMI/RFI environment of the typical nuclear plant. Data collected over several weeks at each of several observation points are required to meet this need. To collect the required data, several approaches are examined, the most promising of which is the relatively new technology of application specific spectral receivers. While several spectral receiver designs have been described in the literature, none is well suited for nuclear power plant EMI/RFI surveys. This paper describes the development of two receivers specifically designed for nuclear power plant EMI/RFI surveys. One receiver surveys electric fields between 5 MHz and 8 GHz, while the other surveys magnetic fields between 305 Hz and 5 MHz. The results of field tests at TVA`s Bull Run Fossil Plant are reported.

  2. A modified LLCL-filter with the reduced conducted EMI noise

    DEFF Research Database (Denmark)

    Wu, Weimin; Sun, Yunjie; Lin, Zhe;

    2013-01-01

    For a transformerless grid-tied converter using Pulse Width Modulation (PWM), the harmonics of grid-injected current, the leakage current and the Electromagnetic Interference (EMI) noise are three important issues during design of the output filter. In this paper, the Common-Mode (CM) and the Dif...... V / 50 Hz single-phase full-bridge grid-tied inverter prototype....

  3. Elektromagnetiline ühildatavus - probleemide jada aastast 1930 : EMC = EMI + EMS / Peeter Lamster

    Index Scriptorium Estoniae

    Lamster, Peeter

    2007-01-01

    Elektrisüsteemist lähtuvast seadmete tööd häirivast elektromagnetilisest inferentsist (EMI), elektromagnetilise haavatavuse (EMS) vähendamisest ja elektromagnetilise ühildatavuse (EMC) tagamisest. Elektromagnetilise ühildatavuse tähtsusest sõjanduses

  4. EMI-Sensor Data to Identify Areas of Manure Accumulation on a Feedlot Surface

    Science.gov (United States)

    A study was initiated to test the validity of using electromagnetic induction (EMI) survey data, a prediction-based sampling strategy and ordinary linear regression modeling to predict spatially variable feedlot surface manure accumulation. A 30 m × 60 m feedlot pen with a central mound was selecte...

  5. Common mode EMI prediction and research in induction motor for electric vehicles

    Science.gov (United States)

    Gao, Yinhan; Wang, Juxian; Yang, Kaiyu; Wang, Tianhao; An, Zhanyang

    2015-02-01

    This paper presents an equivalent circuit of high frequency voltage-controlled switch model of IGBT, and a surge voltage absorption circuit as well. This model can not only significantly reduce the surge voltage, decrease EMI noise, but also obviously inhibit common mode voltage towards the DC power mains.

  6. Evaluation of cable tension sensors of FAST reflector from the perspective of EMI

    Science.gov (United States)

    Zhu, Ming; Wang, Qiming; Egan, Dennis; Wu, Mingchang; Sun, Xiao

    2016-06-01

    The active reflector of FAST (five-hundred-meter aperture spherical radio telescope) is supported by a ring beam and a cable-net structure, in which nodes are actively controlled to form series of real-time paraboloids. To ensure the security and stability of the supporting structure, tension must be monitored for some typical cables. Considering the stringent requirements in accuracy and long-term stability, magnetic flux sensor, vibrating wire strain gauge and fiber bragg grating strain gauge are screened for the cable tension monitoring of the supporting cable-net. Specifically, receivers of radio telescopes have strict restriction on electro magnetic interference (EMI) or radio frequency interference (RFI). These three types of sensors are evaluated from the view of EMI/RFI. Firstly, these fundamentals are theoretically analyzed. Secondly, typical sensor signals are collected in the time and analyzed in the frequency domain, which shows the characteristic in the frequency domain. Finally, typical sensors are tested in an anechoic chamber to get the EMI levels. Theoretical analysis shows that Fiber Bragg Grating strain gauge itself will not lead to EMI/RFI. According to GJB151A, frequency domain analysis and test results show that for the vibrating wire strain gauge and magnetic flux sensor themselves, testable EMI/RFI levels are typically below the background noise of the anechoic chamber. FAST finally choses these three sensors as the monitoring sensors of its cable tension. The proposed study is also a reference to the monitoring equipment selection of other radio telescopes and large structures.

  7. Bioaerosols from the land application of biosolids in the desert southwest USA.

    Science.gov (United States)

    Brooks, J P; Tanner, B D; Josephson, K L; Gerba, C P; Pepper, I L

    2004-01-01

    This study evaluated bioaerosol emissions during land application of Class B biosolids in and around Tucson, Arizona, to aid in developing models of the fate and transport of bioaerosols generated from the land application of biosolids. Samples were collected for 20 min at distances between 2 m and 20 m downwind of point sources, using an SKC BioSampler impinger. A total of six samples were collected per sampling event, which consisted of a biosolid spray applicator applying liquid biosolids to a cotton field. Each application represented one exposure. Samples were collected in deionised water amended with peptone and antifoam agent. Ambient weather conditions were also monitored every 10 min following initiation of sampling. Concurrently with downwind samples, background (ambient) air samples were collected to compensate for any ambient airborne microorganisms. In addition, biosolids samples were collected for analysis of target indicator and pathogenic organisms. Soil samples were also collected and analysed. Significant numbers of heterotrophic plate count (HPC) bacteria were found in air samples collected during the biosolid application process. These could have arisen from soil particles being aerosolised during the land application process. Aerosolised soil may contribute significantly to the amount of aerosolised microorganisms. Soil particles may be able to more readily aerosolise, due to their low density, small particle size and low mass. Aerosolised HPC bacteria found during biosolids land application were similar to those found during normal tractor operation on non-biosolids applied fields. Coliforms and coliphages were not routinely detected even though they were found to be present in the biosolids at relatively high concentrations, 10(6) and 10(4)/g (dry weight) of biosolids respectively. This could be due to the die-off rate of aerosolised Gram-negative bacteria or sorption to the solid portion of the biosolids. Low numbers of aerosolised

  8. Assessment of workers' exposure to bioaerosols in a French cheese factory.

    Science.gov (United States)

    Simon, Xavier; Duquenne, Philippe

    2014-07-01

    Hundreds of different cheeses are produced in France, where 23.9kg of cheese were consumed per inhabitant in 2009, when it was ranked the second cheese-consuming nation. To meet this considerable demand, a large number of cheese factories exist where many workers, especially cheese washers, may be exposed to fungal bioaerosols that can lead to adverse toxinic and allergic effects. Airborne bacteria, fragments, or microbial by-products (endotoxins) are also found and contribute to total worker exposure. However, there is almost no published data concerning worker exposure or characteristics of bioaerosols emitted during these activities. Here, we measured the parameters (concentrations, species present, and size distribution) of the culturable fungal bioaerosol emitted in a French natural-rind cheese-maturing cellar. Concentrations of airborne bacteria and endotoxins were also measured. The main tasks were investigated using stationary or personal sampling over three consecutive days. Depending on the work area, high concentrations of culturable mesophilic microorganisms were measured (using closed-face cassettes): from 10(4) to 2×10(8) CFU m(-3) for fungi and from 10(3) to 10(6) CFU m(-3) for bacteria. These concentrations are 10- to 100000-fold higher than those measured at two reference points (indoor and outdoor) that are assumed not to be contaminated by the plant's activities. Endotoxin concentrations were between 10 and 300 EU m(-3) in the plant. Exposure was further assessed by identifying the predominant culturable fungi (allergenic Mucor fuscus and Penicillium sp.) and by measuring particle size distributions (cascade impactor). Airborne fungal entities (spores, mycelium strands and fragments, agglomerates, etc.) were found with aerodynamic diameters from 3 to over 20 µm. A metrological approach was used to fully characterize the culturable fungal aerosols generated during cheese maturing in this plant. The results show that workers are exposed to

  9. Type and Concentration of Bioaerosols in the Operating Room of Educational Hospitals of Hamadan University of Medical Sciences and Effectiveness of Ventilation Systems, in Year 2004

    Directory of Open Access Journals (Sweden)

    F. Ghorbani Shahna

    2006-07-01

    Full Text Available Introduction & Objective: The bioaerosol is one of the operating room(OR hazards that can be threaten of personel health and capable to creating of postoperetive infection in the patients. Because of the hospital infection rate has correleted to bioaerosol concentration, therefore, it is important to determine of type and concentration of these microorganisms as the main goal of this study. Materials and Methods: In this research, 23 operation rooms in the 4 educational hospitals of the Hamadan City were studied. 115 air samples were collected in the various locations and conditions according to filtration method suggested by bioaerosol committee of ACGIH. The samples were transported to blood agar and cultivated immediatedly. The type and number of colonies were determined in the laberatory then, the bioaerosol concentration were calculated in terms of cfu/m3. The data of physical conditions of ORs , ventilation specifications and other environmental parameters have been recorded in the work sheet.Results: The results have demonstrated that the mean of total bioaerosol and pathogen bioaerosol concentration were 136 cfu/m3 and 4.01 cfu/m3 respectively. The concentration of 25.3% of the total pathogen samples be exceeded of recommended limit. It is apeared that have been correlation between concentration of bioaerosols and duration of surgry (P<0.05, also the concentration of morninig shift were higher than the other shifts(P<0.05.Conclusion: According to the detected bioaerosols pathogens in the samples, high cleaning class in the operating rooms is necessary. It is necessary to design and administrate the ventilation systems according to standards because of the absence of appropriate ventilation system in the three hospitals of four investigated hospitals.

  10. Material particulado y bioaerosoles en el aire de granjas de aves y conejos: cuantificación, caracterización y medidas de reducción

    OpenAIRE

    Adell Sales, Elisa

    2014-01-01

    Los alojamientos ganaderos son una fuente importante de material particulado (“particulate matter”, PM) y bioaerosoles. Estas sustancias tienen un efecto perjudicial tanto para la salud humana y animal como para el medio ambiente. Para reducir los niveles de PM y bioaerosoles en alojamientos ganaderos es necesario conocer el origen de los mismos y los factores que afectan a su generación y suspensión en el aire. Esta Tesis Doctoral aborda aspectos relacionados con la concentrac...

  11. THE EFFECT OF EMI EHF ON ELECTRO - KINETIC POTENTIAL OF CELL NUCLEAR MEMBRANES OF WHEAT SEEDLINGS TREATED WITH HYBBERELLIC ACID

    Directory of Open Access Journals (Sweden)

    Vardevanyan Poghos O

    2013-09-01

    Full Text Available The effect of hybberellic acid and EMI EHF on electro kinetic potential changes of cell nuclear membrane of wheat seedlings has been investigated. It was revealed that electro kinetic potential value depends on functional state of plant organism. It was reported that the treatment of wheat germs with hybberellic acid and EMI EHF induces a change of nuclear membrane surface charge. It was revealed that the combined influence of chemical as well as physical factors induces more pronounced response on biological systems as compared to separately. It was also observed that the effect of EMI EHF has significant effect on water resonant frequencies as compared to water non- resonant frequencies.

  12. Investigation of Fungal Bioaerosols and Particulate Matter in the Teaching-Medical Hospitals of Khorramabad City, Iran During 2015

    Directory of Open Access Journals (Sweden)

    A Sepahvand

    2016-06-01

    Full Text Available Background and Objective: The presence of fungal bioaerosols in hospitals indoor environments have affected the health of patients with the defect in immunity system. Therefore, determination of the rate and species of these agents is essential. This study aimed to investigate association between fungi contamination and particulate matter (PM10, PM2.5 and PM1 concentrations in the main indoor wards and outdoor environment and to determine I/O ratio in two educational-medical hospitals of Khorramabad City. Materials and Methods: In this description-analytical study, the concentration of fungal bioaerosols and particulate matter was measured in 10 indoor parts and 2 outdoor stations over 6 mounts. The sampling was conducted using Quick Take-30 at an airflow rate of 28.3 L/min and sampling period of 2.5 min onto Sabouraud dextrose agar medium containing chloramphenicol. The particulate matters were measured using Monitor Dust-Trak 8520. Moreover, the relative humidity and temperature were recorded using digital TES-1360. Results: Analysis of 288 fungi samples and 864 particulate matter samples showed that the average of fungi accumulation was 59.75 CFU/m3 and the mean concentrations of PM10, PM2.5 and PM1 in the indoor environment was  27.3, 23, and 20.2 µg/m3 respectively. In addition, in ambient air the mean concentration was 135.3 CFU/m3 for fungal bioaerosols and 40.2, 35.7, and 29.8 µg/m3 for PM10, PM2.5 and PM1 respectively. At the total of fungi samples, 12.5% were negative and 87.5% were positive. Having 101.7%, Infection ward was the most contaminated ward. The operation ward in both hospitals showed the minimum fungal contamination. Conclusions: The results of the present study showed that at all of the samplings the ratio of I/O was lower than one. It was noticed the dominancy of fungal bioaerosols and particulate matter of outdoor source on the indoor environment. In addition, a significant correlation (P < 0.001( was found between

  13. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. ...

  14. The seasonal distribution of bioaerosols in municipal landfill sites: a 3-yr study

    Science.gov (United States)

    Huang, Chu-Yun; Lee, Ching-Chang; Li, Fang-Chun; Ma, Yu-Pei; Su, Huey-Jen Jenny

    Landfill is the most common way to dispose waste in many countries, and most landfill sites after closure are often considered for public recreation purposes. It is important that the pollutant levels of closed landfill areas are free of adverse health concerns. However, only limited studies have investigated the airborne biological contamination in closed landfill sites. The objective of this study was to document the bioaerosol levels in a closed landfill site while the temporal, seasonal, and meteorological effects were also taken into accounts. Study site was at one sanitary landfill, taking mostly municipal wastes, in southern Taiwan. Airborne bacteria and fungi were collected on tryptic soy agar (Difco) and malt extract agar (Difco) by a Burkard impactor (Burkard Manufacturing Co. Ltd.) operating at about 10 l m -3 for 30 s. Air samples were collected sequentially in winter, spring, summer and fall in 1998, winter, spring, summer in 1999, as well as summer and fall in 2000. In addition, sampling was conducted in the morning, at noon, in the evening and the following morning during each field assessment. Levels of airborne bacteria and fungi were all far above 10 3 CFU m -3. The concentrations of culturable bacteria and fungi were higher in winter than in other seasons. The difference of bioaerosol level and fungal percentages between the undergoing-closure and closed areas was obvious, and the concentrations were higher in closed area. We therefore recommend that before any complete investigation can be conducted to assure the safety, the closed area of landfill site is probably not ready for immediate public use.

  15. 电磁干扰(EMI)和射频干扰(RFI)及其抑制措施研究%THE STUDY OF EMI/RFI AND ITS REJECTION

    Institute of Scientific and Technical Information of China (English)

    李贵山; 杨建平; 黄晓峰

    2002-01-01

    在电子系统中,强电与弱电交叉耦合的应用环境,干扰错综复杂,严重影响系统的稳定性和可靠性.本文介绍EMI/RFI产生的原因和导入途径,分析并提出了一些行之有效的EMI/RFI抑制方法.

  16. 导电工程塑料在抗EMI/RFI中的设计与应用%Designing and Application of Conductive Engineering Plastics in Resisting EMI/RFI

    Institute of Scientific and Technical Information of China (English)

    方鲲; 曹传宝; 朱鹤孙

    2006-01-01

    高导电性工程塑料是一种抗电磁干扰(EMI/RFI)的高分子复合材料,在电子及微电子工业中的应用越来越广泛和重要.介绍了导电工程塑料的优点及在国内外电子产品和通讯设备中的抗EMI/RFI设计与应用.

  17. Conducted EMI Mitigation Schemes in Isolated Switching Mode Power Supply without the Need of a Y-capacitor

    DEFF Research Database (Denmark)

    Bai, Yongjiang; Yang, Xu; Zhang, Dan;

    2016-01-01

    In order to construct a low impedance loop for common mode electromagnetic interference (EMI) signals, traditional method is to use Y-capacitors as filtering components. However, in the commonly used isolated AC-DC switching mode power supplies (SMPS), the Y-capacitors branch also behaves as a....... The goal of this paper is try to meet these two demands at the same time. In this paper, a novel non-Y-capacitor EMI design concept for SMPS is proposed for the first time. By getting rid of traditional EMI filtering component---the Y-capacitors, the leakage current can be eliminated entirely....... Meanwhile, to face with EMI design challenge, optimized transformer architecture is presented. Analysis of the transformer architecture as well as the auxiliary winding has been carried out. Then a novel topology suitable for non-Y-capacitors converter is proposed and the design procedure of the proposed...

  18. Modeling the deposition of bioaerosols with variable size and shape in the human respiratory tract – A review

    Directory of Open Access Journals (Sweden)

    R. Sturm

    2012-10-01

    Full Text Available The behavior of bioaerosol particles with various size and shape in the human respiratory tract was simulated by using a probabilistic model of the lung and an almost realistic mathematical approach to particle deposition. Results obtained from the theoretical computations clearly show that biogenic particle deposition in different lung compartments does not only depend on physical particle properties, but also on breathing mode (nose or mouth breathing and inhalative flow rate (=tidal volume × breathing frequency/30. Whilst ultrafine (5 μm particles tend to accumulate in the extrathoracic region and the uppermost airways of the tracheobronchial tree, particles with intermediate size are characterized by higher penetration depth, leading to their possible accumulation in the lung alveoli. Due to their deposition in deep lung regions and insufficient clearance, some bioaerosol particles may induce severe lung diseases ranging from infections, allergies, and toxic reactions to cancer.

  19. Assessment of bioaerosol contamination (bacteria and fungi) in the largest urban wastewater treatment plant in the Middle East.

    Science.gov (United States)

    Niazi, Sadegh; Hassanvand, Mohammad Sadegh; Mahvi, Amir Hossein; Nabizadeh, Ramin; Alimohammadi, Mahmood; Nabavi, Samira; Faridi, Sasan; Dehghani, Asghar; Hoseini, Mohammad; Moradi-Joo, Mohammad; Mokamel, Adel; Kashani, Homa; Yarali, Navid; Yunesian, Masud

    2015-10-01

    Bioaerosol concentration was measured in wastewater treatment units in south of Tehran, the largest wastewater treatment plant in the Middle East. Active sampling was carried out around four operational units and a point as background. The results showed that the aeration tank with an average of 1016 CFU/m(3) in winter and 1973 CFU/m(3) in summer had the greatest effect on emission of bacterial bioaerosols. In addition, primary treatment had the highest impact on fungal emission. Among the bacteria, Micrococcus spp. showed the widest emission in the winter, and Bacillus spp. was dominant in summer. Furthermore, fungi such as Penicillium spp. and Cladosporium spp. were the dominant types in the seasons. Overall, significant relationship was observed between meteorological parameters and the concentration of bacterial and fungal aerosols.

  20. EMI-Specific Performance Integrity of OS Migration (Teleportation Over a Wireless Channel Such as WLAN

    Directory of Open Access Journals (Sweden)

    Perambur S. Neelakanta

    2012-08-01

    Full Text Available The performance aspects of OS migration implemented in a wireless LAN (WLAN environment is investigated taking into account of underlying physical-layer based constraints due to EMI/RFI implications in the indoor operations. Specifically, the interfering effects of coexisting IEEE 802.11 devices on OS migration are analyzed {it via} spectrum spill-over effects and host-to-interferer separation. Basic models are presented thereof and computed results are furnished and discussed. While generic studies, for example, on wireless coexistence between IEEE 802.11 and IEEE 802.15.4 devices prevail, no such efforts {it per se} exist on the topic of WLAN supporting OS migration {it vis-à-vis} associated EMI/RFI related impairments in the teleportation. As such, this study can be regarded as a novel attempt.

  1. Novel poly (vinyl butyral) (PVB)/polyaniline-cenosphere composite film for EMI shielding

    Science.gov (United States)

    Bora, Pritom J.; Shahidsha, N.; Madras, Giridhar; Kishore, Ramamurthy, Praveen C.

    2016-05-01

    in-situ synthesis of polyaniline (PANI)/fly ash cenosphere (hollow microspheres) composite was carried out under nitrogen atmosphere at -30±2 °C. Investigated electromagnetic shielding effectiveness (EMI SE) of free standing PVB/PANI-cenosphere (PVBPC) composite films prepared by solution casting indicates an ap preciable shielding. The most effective EMI SE of 30.3 dB was obtained for 197±3 µm thicker flexible film over the frequency range 8.2-12.4 GHz. Mechanistically, absorption was found to be dominant. The obtained shielding effectiveness due to absorbance (SEA) of PVBPC film is more than two times higher than PVB/PANI composite film. In the presence of hollow PANI-cenospheres in PVB matrix the time average power of incident electromagnetic wave decreases resulting in an increase of absorbance.

  2. UWB EMI To Aircraft Radios: Field Evaluation on Operational Commercial Transport Airplanes. Volume 1

    Science.gov (United States)

    Oria, A. J. (Editor); Ely, Jay J.; Martin, Warren L.; Shaver, Timothy W.; Fuller, Gerald L.; Zimmerman, John; Fuschino, Robert L.; Larsen, William E.

    2005-01-01

    Ultrawideband (UWB) transmitters may soon be integrated into a wide variety of portable electronic devices (PEDs) that passengers routinely carry on board commercial airplanes. Airlines and the FAA will have difficulty controlling passenger use of UWB transmitters during flights with current airline policies and existing wireless product standards. The aeronautical community is concerned as to whether evolving FCC UWB rules are adequate to protect legacy and emerging aeronautical radio systems from electromagnetic interference (EMI) from emerging UWB products. To address these concerns, the NASA Office of Space Communications and Chief Spectrum Managers assembled a multidisciplinary team from NASA LaRC, NASA JPL, NASA ARC, FAA, United Airlines, Sky West Airlines, and Eagles Wings Inc. to carry out a comprehensive series of tests aimed at determining the nature and extent of any EMI to aeronautical communication and navigation systems from UWB devices meeting FCCapproved and proposed levels for unlicensed handheld transmitters.

  3. Deoxyribonucleic acid-Ag nanoparticles for EMI Shielding: the effect of nanoparticle size, shape and distribution on the shielding effectiveness

    Science.gov (United States)

    Ouchen, Fahima; Wilson, Benjamin G.; Yaney, Perry P.; Salour, Michael M.; Grote, James G.

    2014-09-01

    This study focuses on the use of silver based nanoparticle as fillers in DNA host materials to form nancomposites for applications in Electro-Magnetic Interferences (EMI) shielding. For relatively low-conductivity EMI shielding nanocomposites, silver-oxide coated cenospheres are investigated as fillers. The filler loadings are varied to determine a percolation threshold for the desired low conductivity and shielding effectiveness. Microwave absorption as well as DC surface resistivity measurements are undertaken to characterize the obtained films.

  4. Crackle template based metallic mesh with highly homogeneous light transmission for high-performance transparent EMI shielding

    OpenAIRE

    Yu Han; Jie Lin; Yuxuan Liu; Hao Fu; Yuan Ma; Peng Jin; Jiubin Tan

    2016-01-01

    Our daily electromagnetic environment is becoming increasingly complex with the rapid development of consumer electronics and wireless communication technologies, which in turn necessitates the development of electromagnetic interference (EMI) shielding, especially for transparent components. We engineered a transparent EMI shielding film with crack-template based metallic mesh (CT-MM) that shows highly homogeneous light transmission and strong microwave shielding efficacy. The CT-MM film is ...

  5. THE IMPLEMENTATION OF EMI (ENGLISH MEDIUM INSTRUCTION IN INDONESIAN UNIVERSITIES: ITS OPPORTUNITIES, ITS THREATS, ITS PROBLEMS, AND ITS POSSIBLE SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Jusuf Ibrahim

    2001-01-01

    Full Text Available In this paper, I attempt to find out whether EMI (English Medium Instruction can be an effective means of enhancing students' and teachers' language proficiency at university (bilingualism and whether bilingualism necessarily leads to biliteracy. In addition, I would like to propose a model on which a smooth transition to a full EMI implementation can be achieved, should it be adopted. From literature reviews, I conclude that EMI (using English to teach content subjects can be a better means of solving learners' language problems than teaching English as a subject, because it allows learners more exposure to the language (comprehensible input and more opportunity to use it (comprehensible output. However, due to its classroom-based nature, EMI is not likely to develop the four language skills (listening, reading, speaking, & writing equally for both students and teachers. On the other hand, the assumption that EMI will automatically result in biliteracy is unsupported, because only bilinguals competent in both languages can take a full advantage of their bilingualism. Students or teachers who are not adequately developed in the language are likely to suffer academically, socially, and psychologically instead. Since research has found that total/full immersion is not the right method for language-incompetent students, the writer believes that both a bridging program and a partial EMI program are necessary at least at the initial stage of EMI implementation. The bridging program should be based on students' and teachers' academic and linguistic needs (EAP; the partial EMI program may be based on limitations on three factors: the participants, the scope of use, and the settings. Finally, in order for the program to run smoothly, mixed-mode teaching in the classroom should be discouraged and a conducive atmosphere for second language acquisition should be established both in the classroom and outside the classroom

  6. Impact of dielectric deterioration on the conducted EMI emissions in the DC-DC boost converter

    OpenAIRE

    Musznicki, Piotr; Schanen, Jean-Luc; Granjon, Pierre; Јuszcz, Jarosław

    2011-01-01

    International audience The magnitude of emitted noise generated by DC-DC converters depends on their electrical behavior and parameters. Some of these can change during the converter life time, especially due to some deterioration process. In this paper the impact of the dielectric materials aging is presented using both circuit simulation and a digital signal processing method based on Wiener filtering. The change of the total EMI spectrum as a function of the dielectric property has been...

  7. ELECTROLESS NICKEL DEPOSITION ON FRAXINUS MANDSHURICA VENEER MODIFIED WITH APTHS FOR EMI SHIELDING

    OpenAIRE

    Haibing Liu; Lijuan Wang

    2010-01-01

    Electroless nickel deposition was carried out on Fraxinus mandshurica veneers for EMI shielding under a new activation process. In the process, Pd(II) was absorbed on the surface of veneers modified with γ-aminopropyltrihydroxysilane (APTHS) obtained from the hydrolysis of γ-aminopropyltriethoxysilane (APTES). After the reduction, electroless plating was successfully initiated, and Ni-P coating was deposited on the veneers. The activation process and resulting coating were characterized by XP...

  8. A Review on the Production Methods and Testing of Textiles for Electro Magnetic Interference (EMI) shielding

    OpenAIRE

    Bagavathi M,; Dr.-Ing. Priyadarshini R

    2015-01-01

    The need of the present generation to protect themselves from electromagnetic radiation due the various technological developments has paved way to the birth of EMI shielding of textiles. The shielding effectiveness of the developed fabric will vary depending upon the fabric or the coating constituents. The shielding requirements for different applications vary widely which has resulted in the development of wide variety of shielding mechanisms and materials which can be used in t...

  9. EMI StAR – Definition of a Storage Accounting Record

    CERN Document Server

    Nilsen, J.K.; Müller-Pfefferkorn, R.; Molnar, Z.; Zappi, R.

    2011-01-01

    In this document the EU-project European Middleware Initiative (EMI) describes a storage accounting record (StAR), defined to reflect practical, financial and legal requirements of storage location, usage and space and data flow. The defined record might be the base for a standardized schema or an extension of an existing record like the OGF UR and this document is intended as information to be taken as input for incorporating storage resources into the OGF UR.

  10. Flexible EMI shielding materials derived by melt blending PVDF and ionic liquid modified MWNTs

    Science.gov (United States)

    Sharma, Maya; Sharma, Sukanya; Abraham, Jiji; Thomas, Sabu; Madras, Giridhar; Bose, Suryasarathi

    2014-09-01

    Nano composites of PVDF with ionic liquid [EMIM][TF2N] (IL) modified MWNTs were prepared by melt blending to design materials for EMI shielding applications. MWNTs and IL were mixed in two different ratios (1:1 and 1:5) to facilitate better dispersion of MWNTs in PVDF. It was observed that non-covalent interactions between IL and PVDF resulted in a better dispersion of CNTs and was consistent with increasing concentration of IL. Interestingly, IL modified MWNTs induced the formation of γ-phase crystals in PVDF, which was further confirmed by XRD, FTIR and DSC. Melt rheological measurements and DSC analysis revealed the plasticization effect of IL in PVDF composites further manifesting in a decrease in the storage modulus and the glass transition temperature. This phenomenal effect presumably led to better dispersion of IL modified MWNTs in PVDF further resulting in a significant improvement in electrical conductivity and structural properties. More interestingly, the elongational properties in the composites improved with IL modified MWNTs in striking contrast to MWNT filled PVDF composites. The ac conductivity of the composites reached about 10-3 S cm-1 with the addition of 2 wt% IL modified MWNTs (1:1). This further led to a high electro-magnetic interference (EMI) shielding effectiveness of about 20 dB at 2 wt% IL modified MWNTs. Such materials can further be explored for flexible, lightweight EMI shielding materials for a wide range of operating frequency.

  11. Natural fiber composites with EMI shielding function fabricated using VARTM and Cu film magnetron sputtering

    Science.gov (United States)

    Xia, Changlei; Ren, Han; Shi, Sheldon Q.; Zhang, Hualiang; Cheng, Jiangtao; Cai, Liping; Chen, Kathleen; Tan, Hwa-Shen

    2016-01-01

    To fabricate kenaf fiber composites with electromagnetic interference (EMI) shielding function, the technique of vacuum-assisted resin transfer molding (VARTM) and Cu film magnetron sputtering were employed. The EMI shielding effectiveness (SE) and composite surface characteristics were examined with PNA Network Analyzer, Quanta 200 environmental scanning electron microscope and OCA20 contact angle meter. After being Cu-sputter coated for 0.5 h, 1 h, 2 h, and 3 h, the EMI SE values were increased to be 23.8 dB, 32.5 dB, 43.3 dB, and 48.3 dB, which denoted 99.5799%, 99.9437%, 99.9953%, or 99.9985% incident signal was blocked, respectively. The SEM observations revealed that the smoother surface of the composites was obtained by longer time sputtering, resulting in the SE improvement. The contact angle increased from 49.6° to 129.5° after 0.5 h sputtering, which indicated that the coated Cu film dramatically improved the hydrophobic property of composite. When the coating time increased to 3 h, the contact angle decreased to 51.0° because the composite surface roughness decreased with the increase in coating time.

  12. Superhydrophobic and conductive carbon nanofiber/PTFE composite coatings for EMI shielding.

    Science.gov (United States)

    Das, Arindam; Hayvaci, Harun T; Tiwari, Manish K; Bayer, Ilker S; Erricolo, Danilo; Megaridis, Constantine M

    2011-01-01

    This paper presents a solvent-based, mild method to prepare superhydrophobic, carbon nanofiber/PTFE-filled polymer composite coatings with high electrical conductivity and reports the first data on the effectiveness of such coatings as electromagnetic interference (EMI) shielding materials. The coatings are fabricated by spraying dispersions of carbon nanofibers and sub-micron PTFE particles in a polymer blend solution of poly(vinyledene fluoride) and poly(methyl methacrylate) on cellulosic substrates. Upon drying, coatings display static water contact angles as high as 158° (superhydrophobic) and droplet roll-off angles of 10° indicating self-cleaning ability along with high electrical conductivities (up to 309 S/m). 100 μm-thick coatings are characterized in terms of their EMI shielding effectiveness in the X-band (8.2-12.4 GHz). Results show up to 25 dB of shielding effectiveness, which changed little with frequency at a fixed composition, thus indicating the potential of these coatings for EMI shielding applications and other technologies requiring both extreme liquid repellency and high electrical conductivity. PMID:20889160

  13. Thickness mode EMIS of constrained proof-mass piezoelectric wafer active sensors

    Science.gov (United States)

    Kamas, Tuncay; Giurgiutiu, Victor; Lin, Bin

    2015-11-01

    This paper addresses theoretical and experimental work on thickness-mode electromechanical (E/M) impedance spectroscopy (EMIS) of proof-mass piezoelectric wafer active sensors (PMPWAS). The proof-mass (PM) concept was used to develop a new method for tuning the ultrasonic wave modes and for relatively high frequency local modal sensing by the PM affixed on PWAS. In order to develop the theoretical basis of the PMPWAS tuning concept, analytical analyses were conducted by applying the resonator theory to derive the EMIS of a PWAS constrained on one and both surfaces by isotropic elastic materials. The normalized thickness-mode shapes were obtained for the normal mode expansion (NME) method to eventually predict the thickness-mode EMIS using the correlation between PMPWAS and the structural dynamic properties of the substrate. Proof-masses of different sizes and materials were used to tune the system resonance towards an optimal frequency point. The results were verified by coupled-field finite element analyses (CF-FEA) and experimental results. An application of the tuning effect of PM on the standing wave modes was discussed as the increase in PM thickness shifts the excitation frequency of the wave mode toward the surface acoustic wave (SAW) mode.

  14. Eduquer par la musique

    OpenAIRE

    Zhe, Ji

    2011-01-01

    La politique et l’éducation sont indissociables dans les tentatives de promouvoir le confucianisme en Chine contemporaine. L’union alors célébrée du sacré, du pouvoir et du savoir s’inscrit en tension avec une modernité d’abord caractérisée par la différenciation des institutions et des valeurs. Partant de ce constat, l’article étudie le cas particulier d’une société engagée depuis 2000 dans l’initiation des enfants à la musique classique et dans la promotion de la « culture de soi » chez les...

  15. ParB spreading requires DNA bridging

    NARCIS (Netherlands)

    Graham, Thomas G. W.; Wang, Xindan; Song, Dan; Etson, Candice M.; van Oijen, Antoine M.; Rudner, David Z.; Loparo, Joseph J.

    2014-01-01

    The parABS system is a widely employed mechanism for plasmid partitioning and chromosome segregation in bacteria. ParB binds to parS sites on plasmids and chromosomes and associates with broad regions of adjacent DNA, a phenomenon known as spreading. Although essential for ParB function, the mechani

  16. Time-Based Measurement of Personal Mite Allergen Bioaerosol Exposure over 24 Hour Periods.

    Science.gov (United States)

    Tovey, Euan R; Liu-Brennan, Damien; Garden, Frances L; Oliver, Brian G; Perzanowski, Matthew S; Marks, Guy B

    2016-01-01

    Allergic diseases such as asthma and rhinitis are common in many countries. Globally the most common allergen associated with symptoms is produced by house dust mites. Although the bed has often been cited as the main site of exposure to mite allergens, surprisingly this has not yet been directly established by measurement due to a lack of suitable methods. Here we report on the development of novel methods to determine the pattern of personal exposure to mite allergen bioaerosols over 24-hour periods and applied this in a small field study using 10 normal adults. Air was sampled using a miniature time-based air-sampler of in-house design located close to the breathing zone of the participants, co-located with a miniature time-lapse camera. Airborne particles, drawn into the sampler at 2L/min via a narrow slot, were impacted onto the peripheral surface of a disk mounted on the hour-hand of either a 12 or 24 hour clock motor. The impaction surface was either an electret cloth, or an adhesive film; both novel for these purposes. Following a review of the time-lapse images, disks were post-hoc cut into subsamples corresponding to eight predetermined categories of indoor or outdoor location, extracted and analysed for mite allergen Der p 1 by an amplified ELISA. Allergen was detected in 57.2% of the total of 353 subsamples collected during 20 days of sampling. Exposure patterns varied over time. Higher concentrations of airborne mite allergen were typically measured in samples collected from domestic locations in the day and evening. Indoor domestic Der p 1 exposures accounted for 59.5% of total exposure, whereas total in-bed-asleep exposure, which varied 80 fold between individuals, accounted overall for 9.85% of total exposure, suggesting beds are not often the main site of exposure. This study establishes the feasibility of novel methods for determining the time-geography of personal exposure to many bioaerosols and identifies new areas for future technical

  17. EMI/RFI电缆屏蔽导电热缩管%Conductive Heat-shrink Tubing for EMI/RFI Cable Shielding

    Institute of Scientific and Technical Information of China (English)

    张世麟; 安俊娥; 李建平

    2004-01-01

    随着高速计算机和数据通讯设备的快速增长和需求,这些设备对电磁干扰(EMI)和射频干扰(RFI)的敏感度已成为日益突出的问题和挑战。在如今拥有高级电子系统的世界,敏感度表现为两种方式:系统内部传导的EMI/RFI引发自身功能紊乱;辐射的EMI/RFI引起相邻设备功能紊乱。

  18. Bayesian optimal classification of metallic objects: a comparison of time-domain and frequency-domain EMI performance

    Science.gov (United States)

    Gao, Ping; Collins, Leslie M.; Carin, Lawrence

    2000-08-01

    Traditionally, field EMI sensors are operated in the time- domain. The time-domain (TD) EMI sensor usually is a pulsed system. It contains both a transmitting coil and a receiving coil. After transmitting an excitation pulse, which generates the primary field, the receiving coil records the secondary field in the late time. Since a TD EMI sensor measures only the late-time responses, the information contained in the early time response is lost thus limiting the types of objects that can be discriminated. Alternatively, EMI sensors can be operated in the frequency- domain (FD). In this case, the excitations are sinusoidal signals and the sensor measures the static response. The advantages and disadvantages of TD and FD EMI sensors are reviewed in this paper. For landmine and UXO detection, discrimination of targets of interest from clutter is required, since the cost of large false alarm rates is substantial amounts of money, labor and time. In order to discriminate targets from clutter, Bayesian optimal classifiers are derived. Traditional detectors for these applications only utilize the energy of the signal at the position under test or the output of a matched world scenario, the depth of the underground objects is uncertain. The optimal classifier that we utilize takes these uncertainties into account also. In this paper, we present classification performance for four metal objects using TD and FD EMI data. Experimental data were taken with the PSS- 12, a standard army issued metal detector, and the GEM-3, a prototype frequency-domain EMI sensor. Although the optimal classifier improves performance for both TD and FD data, FD classification rate are higher than those for TD systems. The theoretical basis for this result is explored.

  19. Reducing bioaerosol dispersion from wastewater treatment and its land application: a review and analysis.

    Science.gov (United States)

    O'Hara, Richard E; Rubin, Robert

    2005-09-01

    Wastewater treatment systems and spray irrigation of treated water may spread microorganisms such as bacteria and viruses through dispersion of aerosol particles. A recent review (Brooks, Josephson, Gerba, & Pepper, 2004) identifies appropriate reports. Teltsch and co-authors report findings that suggest effective management controls involve providing buffer zones, irrigating in the daytime and in times of low humidity, reducing microorganism levels in water used for spraying, and testing for multiple types of viruses and bacteria (Teltsch & Katzenelson, 1978; Teltsch, Shuval, & Tadmor, 1980; Teltsch, Kedmi, Bonnet, Borenzstajn-Rotem, & Katzenelson, 1980). Camann, Moore, Harding, and Sorber support these findings. They also note that fecal streptococci are hardier than fecal coliform and appear frequently in background samples, suggesting that this bacterium is a better indicator of background and downwind conditions than are fecal coliform bacteria. In their study, storage prior to spray irrigation reduced microorganism concentrations by 99 percent. Downwind concentrations of sprayed reservoir water were often comparable to background values (Camann, Moore, Harding, & Sorber, 1988). Italian researchers (Brandi, Sisti, & Amagliani, 2000; Carducci, Gemelli, Cantiani, Casini, & Rovini, 1999; Carducci et al., 2000) confirm variable die-away rates of microorganisms, observe a positive association between fecal streptococci and the presence of viruses, and recommend consideration of submerged aeration for sludge digestion at sewage treatment plants. No reports are available that measure dispersion of bioaerosols from wastewater consistently treated to meet contemporary disinfection standards. PMID:16220719

  20. Reducing bioaerosol dispersion from wastewater treatment and its land application: a review and analysis.

    Science.gov (United States)

    O'Hara, Richard E; Rubin, Robert

    2005-09-01

    Wastewater treatment systems and spray irrigation of treated water may spread microorganisms such as bacteria and viruses through dispersion of aerosol particles. A recent review (Brooks, Josephson, Gerba, & Pepper, 2004) identifies appropriate reports. Teltsch and co-authors report findings that suggest effective management controls involve providing buffer zones, irrigating in the daytime and in times of low humidity, reducing microorganism levels in water used for spraying, and testing for multiple types of viruses and bacteria (Teltsch & Katzenelson, 1978; Teltsch, Shuval, & Tadmor, 1980; Teltsch, Kedmi, Bonnet, Borenzstajn-Rotem, & Katzenelson, 1980). Camann, Moore, Harding, and Sorber support these findings. They also note that fecal streptococci are hardier than fecal coliform and appear frequently in background samples, suggesting that this bacterium is a better indicator of background and downwind conditions than are fecal coliform bacteria. In their study, storage prior to spray irrigation reduced microorganism concentrations by 99 percent. Downwind concentrations of sprayed reservoir water were often comparable to background values (Camann, Moore, Harding, & Sorber, 1988). Italian researchers (Brandi, Sisti, & Amagliani, 2000; Carducci, Gemelli, Cantiani, Casini, & Rovini, 1999; Carducci et al., 2000) confirm variable die-away rates of microorganisms, observe a positive association between fecal streptococci and the presence of viruses, and recommend consideration of submerged aeration for sludge digestion at sewage treatment plants. No reports are available that measure dispersion of bioaerosols from wastewater consistently treated to meet contemporary disinfection standards.

  1. Detection of biological particles in ambient air using Bio-Aerosol Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    McJimpsey, E L; Steele, P T; Coffee, K R; Fergenson, D P; Riot, V J; Woods, B W; Gard, E E; Frank, M; Tobias, H J; Lebrilla, C

    2006-03-16

    The Bio-Aerosol Mass Spectrometry (BAMS) system is an instrument used for the real time detection and identification of biological aerosols. Particles are drawn from the atmosphere directly into vacuum and tracked as they scatter light from several continuous wave lasers. After tracking, the fluorescence of individual particles is excited by a pulsed 266nm or 355nm laser. Molecules from those particles with appropriate fluorescence properties are subsequently desorbed and ionized using a pulsed 266nm laser. Resulting ions are analyzed in a dual polarity mass spectrometer. During two field deployments at the San Francisco International Airport, millions of ambient particles were analyzed and a small but significant fraction were found to have fluorescent properties similar to Bacillus spores and vegetative cells. Further separation of non-biological background particles from potential biological particles was accomplished using laser desorption/ionization mass spectrometry. This has been shown to enable some level of species differentiation in specific cases, but the creation and observation of higher mass ions is needed to enable a higher level of specificity across more species. A soft ionization technique, matrix-assisted laser desorption/ionization (MALDI) is being investigated for this purpose. MALDI is particularly well suited for mass analysis of biomolecules since it allows for the generation of molecular ions from large mass compounds that would fragment under normal irradiation. Some of the initial results from a modified BAMS system utilizing this technique are described.

  2. Assessment of soil electromagnetic parameters and their variation with soil water, salts: a comparison among EMI and TDR measuring methods

    Science.gov (United States)

    Chaali, Nesrine; Coppola, Antonio; Comegna, Alessandro; Dragonetti, Giovanna

    2015-04-01

    Numerous studies have analyzed the possibility of the extension of Electromagnetic Induction EMI calibration coefficients determined at field scale, to predict the depth distribution of bulk electrical conductivity ECb within unmonitored sites and/or times, in order to appraise the effect of salts dynamics on soils and plants. However, in the literature, it has been determined that the extension of those EMI calibration coefficients can be awkward since the calibration parameters are highly site-specific because of changes in water content, temperature, root development, soil physical properties, etc... So they can only be used in sites having similar characteristics in terms of EMI. Furthermore there is a difference in the observation windows of EMI sensors and of sensors (Time Domain Reflectometry TDR, Electrical Resistance Tomography ERT, ect...) used for measuring the ECb to be then used for the calibration and validation of the EMI. By consequence the actual variability of the soil salinity will be hidden due to the fact that data coming from EMI and other sensors have different variability patterns and structure, and are then influenced by different noises. The main objectives of this work were: 1) develop a practical and cost-effective technique that uses TDR data as ground-truth data for calibrating and validating of the EMI larger scale sensor, 2) using a Fourier transform FT analysis by applying a specific noise filter to the original data, to find the correlations between the TDR and the EMI data. An experiment was designed by irrigating three transects of green beans, 30 m long each, with three irrigation salinity inputs (1dSm-1, 3dSm-1, 6dSm-1). The irrigation volumes were estimated by measuring soil water content at different depths by using a Diviner 2000. During the experiment, the EM in both the vertical (EMV) and horizontal (EMH) configurations were regularly measured by a Geonics EM38 device. TDR probes were inserted vertically at the soil

  3. Adapting physically complete models to vehicle-based EMI array sensor data: data inversion and discrimination studies

    Science.gov (United States)

    Shubitidze, Fridon; Miller, Jonathan S.; Schultz, Gregory M.; Marble, Jay A.

    2010-04-01

    This paper reports vehicle based electromagnetic induction (EMI) array sensor data inversion and discrimination results. Recent field studies show that EMI arrays, such as the Minelab Single Transmitter Multiple Receiver (STMR), and the Geophex GEM-5 EMI array, provide a fast and safe way to detect subsurface metallic targets such as landmines, unexploded ordnance (UXO) and buried explosives. The array sensors are flexible and easily adaptable for a variety of ground vehicles and mobile platforms, which makes them very attractive for safe and cost effective detection operations in many applications, including but not limited to explosive ordnance disposal and humanitarian UXO and demining missions. Most state-of-the-art EMI arrays measure the vertical or full vector field, or gradient tensor fields and utilize them for real-time threat detection based on threshold analysis. Real field practice shows that the threshold-level detection has high false alarms. One way to reduce these false alarms is to use EMI numerical techniques that are capable of inverting EMI array data in real time. In this work a physically complete model, known as the normalized volume/surface magnetic sources (NV/SMS) model is adapted to the vehicle-based EMI array, such as STMR and GEM-5, data. The NV/SMS model can be considered as a generalized volume or surface dipole model, which in a special limited case coincides with an infinitesimal dipole model approach. According to the NV/SMS model, an object's response to a sensor's primary field is modeled mathematically by a set of equivalent magnetic dipoles, distributed inside the object (i.e. NVMS) or over a surface surrounding the object (i.e. NSMS). The scattered magnetic field of the NSMS is identical to that produced by a set of interacting magnetic dipoles. The amplitudes of the magnetic dipoles are normalized to the primary magnetic field, relating induced magnetic dipole polarizability and the primary magnetic field. The magnitudes of

  4. 室内生物气溶胶颗粒行为特性研究%Study on Particles Behavioral of Indoor Bioaerosols

    Institute of Scientific and Technical Information of China (English)

    陈小明; 刘迎云; 刘泽华; 刘飞

    2011-01-01

    Bioaerosols, a membership of aerosol category, Its particle pollution characteristics on indoor air quality and human health effects are drawing more and more attention. This paper systematically reviews recent researches of domestic and overseas scholars on particles behavior of bioaerosols, and finally discusses the development direction of indoor bioaerosols particles behavior research.%生物气溶胶隶属气溶胶范畴,其颗粒污染特性对室内空气质量及人体健康的影响越来越受到人们的重视。本文较系统地综述了近年来国内外学者在生物气溶胶颗粒行为特性上的研究进展,并探讨了今后室内生物气溶胶颗粒行为研究的发展方向。

  5. Chaos analysis and chaotic EMI suppression of DC-DC converters

    CERN Document Server

    Zhang, Bo

    2014-01-01

    Introduces chaos theory, its analytical methods and the means to apply chaos to the switching power supply design DC-DC converters are typical switching systems which have plenty of nonlinear behaviors, such as bifurcation and chaos. The nonlinear behaviors of DC-DC converters have been studied heavily over the past 20 years, yet researchers are still unsure of the practical application of bifurcations and chaos in switching converters. The electromagnetic interference (EMI), which resulted from the high rates of changes of voltage and current, has become a major design criterion in DC-DC co

  6. Mitigation of Radiation and EMI Effects on the Vacuum Control System of LHC

    CERN Document Server

    Pigny, G; Krakowski, P; Rio, B

    2014-01-01

    The 26 km of vacuum chambers where circulates the beam of the Large Hadron Collider (LHC) must be maintained under Ultra High Vacuum (UHV) to minimize the beam interactions with residual gases, and allow the operation of specific systems. The vacuum level is measured by several thousands of gauges along the accelerator. Bad vacuum quality may trigger a beam dump and close the associated sector valves. The effects of radiation or Electromagnetic Interferences (EMI) on components that may stop the machine must be evaluated and minimized. We report on the actions implemented to mitigate their impact on the vacuum control system.

  7. A Review on the Production Methods and Testing of Textiles for Electro Magnetic Interference (EMI shielding

    Directory of Open Access Journals (Sweden)

    Bagavathi M,

    2015-02-01

    Full Text Available The need of the present generation to protect themselves from electromagnetic radiation due the various technological developments has paved way to the birth of EMI shielding of textiles. The shielding effectiveness of the developed fabric will vary depending upon the fabric or the coating constituents. The shielding requirements for different applications vary widely which has resulted in the development of wide variety of shielding mechanisms and materials which can be used in the production of shielding equipment and work wear. In addition to their production, testing of shielding gears involves various methods to be adopted depending on the application.

  8. EMI and BER/PER Analysis of Wi-Fi and Bluetooth Communication for CRIP Platform

    DEFF Research Database (Denmark)

    Ravelo, Blaise; Cabral, Jorge; Wagner, Stefan Rahr;

    This paper is devoted to the characterization of the electromagnetic interference (EMI) effects on wireless communication devices for telemedicine healthcare application. The proposed wireless system operates at the 2.4GHz ISM band with a hardware interface communicating by Wi-Fi and BLE (Bluetooth...... path loss model is investigated for the indoor RF link budget. The quality of the EM coverage and SNR and SINR on QoS with transmitted data BER and PER is analysed. It was examined that the QoS can be degraded according to the distance between the Wi-Fi and BLE device sensitivity and also...

  9. A Novel Method and Its Application to Measuring Pathogen Decay in Bioaerosols from Patients with Respiratory Disease.

    Science.gov (United States)

    Johnson, Graham R; Knibbs, Luke D; Kidd, Timothy J; Wainwright, Claire E; Wood, Michelle E; Ramsay, Kay A; Bell, Scott C; Morawska, Lidia

    2016-01-01

    This work aimed to develop an in vivo approach for measuring the duration of human bioaerosol infectivity. To achieve this, techniques designed to target short-term and long-term bioaerosol aging, were combined in a tandem system and optimized for the collection of human respiratory bioaerosols, without contamination. To demonstrate the technique, cough aerosols were sampled from two persons with cystic fibrosis and chronic Pseudomonas aeruginosa infection. Measurements and cultures from aerosol ages of 10, 20, 40, 900 and 2700 seconds were used to determine the optimum droplet nucleus size for pathogen transport and the airborne bacterial biological decay. The droplet nuclei containing the greatest number of colony forming bacteria per unit volume of airborne sputum were between 1.5 and 2.6 μm. Larger nuclei of 3.9 μm, were more likely to produce a colony when impacted onto growth media, because the greater volume of sputum comprising the larger droplet nuclei, compensated for lower concentrations of bacteria within the sputum of larger nuclei. Although more likely to produce a colony, the larger droplet nuclei were small in number, and the greatest numbers of colonies were instead produced by nuclei from 1.5 to 5.7 μm. Very few colonies were produced by smaller droplet nuclei, despite their very large numbers. The concentration of viable bacteria within the dried sputum comprising the droplet nuclei exhibited an orderly dual decay over time with two distinct half-lives. Nuclei exhibiting a rapid biological decay process with a 10 second half-life were quickly exhausted, leaving only a subset characterized by a half-life of greater than 10 minutes. This finding implied that a subset of bacteria present in the aerosol was resistant to rapid biological decay and remained viable in room air long enough to represent an airborne infection risk. PMID:27388489

  10. A Novel Method and Its Application to Measuring Pathogen Decay in Bioaerosols from Patients with Respiratory Disease.

    Directory of Open Access Journals (Sweden)

    Graham R Johnson

    Full Text Available This work aimed to develop an in vivo approach for measuring the duration of human bioaerosol infectivity. To achieve this, techniques designed to target short-term and long-term bioaerosol aging, were combined in a tandem system and optimized for the collection of human respiratory bioaerosols, without contamination. To demonstrate the technique, cough aerosols were sampled from two persons with cystic fibrosis and chronic Pseudomonas aeruginosa infection. Measurements and cultures from aerosol ages of 10, 20, 40, 900 and 2700 seconds were used to determine the optimum droplet nucleus size for pathogen transport and the airborne bacterial biological decay. The droplet nuclei containing the greatest number of colony forming bacteria per unit volume of airborne sputum were between 1.5 and 2.6 μm. Larger nuclei of 3.9 μm, were more likely to produce a colony when impacted onto growth media, because the greater volume of sputum comprising the larger droplet nuclei, compensated for lower concentrations of bacteria within the sputum of larger nuclei. Although more likely to produce a colony, the larger droplet nuclei were small in number, and the greatest numbers of colonies were instead produced by nuclei from 1.5 to 5.7 μm. Very few colonies were produced by smaller droplet nuclei, despite their very large numbers. The concentration of viable bacteria within the dried sputum comprising the droplet nuclei exhibited an orderly dual decay over time with two distinct half-lives. Nuclei exhibiting a rapid biological decay process with a 10 second half-life were quickly exhausted, leaving only a subset characterized by a half-life of greater than 10 minutes. This finding implied that a subset of bacteria present in the aerosol was resistant to rapid biological decay and remained viable in room air long enough to represent an airborne infection risk.

  11. SUPPRESSING CONDUCTED EMI FROM A DC/DC HIGH POWER CONVERTER BASED ON MIXED-MODE FILTER

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Conducted electromagnetic interference (EMI) from a 7.5kVA DC/DC high power converter is investigated to agree with EN class A. Here in some passive methods of suppressing conducted EM Noise, such as mixed-mode (MM) EMI filters, snubbing circuits and other means, are used. Based on measurement, the sources of noise are detected with the characteristics analyzed in detail. The MM EMI filters is valuable means with which low-frequency part and some of the high frequency part of conducted EM Noise can be efficiently reduced. How to lay out the MM filters on both sides of the converter is outlined in detail. In addition, multiple grounding and RDC snubbing circuits are employed to improve the performance in high frequency. The experimental results confirm the methods adopted.

  12. Crackle template based metallic mesh with highly homogeneous light transmission for high-performance transparent EMI shielding

    Science.gov (United States)

    Han, Yu; Lin, Jie; Liu, Yuxuan; Fu, Hao; Ma, Yuan; Jin, Peng; Tan, Jiubin

    2016-05-01

    Our daily electromagnetic environment is becoming increasingly complex with the rapid development of consumer electronics and wireless communication technologies, which in turn necessitates the development of electromagnetic interference (EMI) shielding, especially for transparent components. We engineered a transparent EMI shielding film with crack-template based metallic mesh (CT-MM) that shows highly homogeneous light transmission and strong microwave shielding efficacy. The CT-MM film is fabricated using a cost-effective lift-off method based on a crackle template. It achieves a shielding effectiveness of ~26 dB, optical transmittance of ~91% and negligible impact on optical imaging performance. Moreover, high–quality CT-MM film is demonstrated on a large–calibre spherical surface. These excellent properties of CT-MM film, together with its advantages of facile large-area fabrication and scalability in processing on multi-shaped substrates, make CT-MM a powerful technology for transparent EMI shielding in practical applications.

  13. X-band EMI shielding mechanisms and shielding effectiveness of high structure carbon black/polypropylene composites

    Science.gov (United States)

    Al-Saleh, Mohammed H.; Sundararaj, Uttandaraman

    2013-01-01

    The electromagnetic interference (EMI) shielding effectiveness (SE) and EMI shielding mechanisms of high structure carbon black (HS-CB)/polypropylene (PP) composites in the X-band frequency range were studied. Composite plates with three different thicknesses and five different electrical conductivities were studied. The reflection loss and absorption loss of the composites were quantified based on the electromagnetic radiation power balance. The results showed that for HS-CB/PP composites, absorption loss contribution to the overall attenuation is more than the contribution of the reflection loss. The ability of the theoretical model to predict the EMI shielding by reflection and absorption was found to be a function of the shielding plate thickness and conductivity.

  14. Differential mode EMI filter design for ultra high efficiency partial parallel isolated full-bridge boost converter

    DEFF Research Database (Denmark)

    Makda, Ishtiyaq Ahmed; Nymand, M.

    2013-01-01

    This paper presents a practical method to design a Differential Mode EMI filter for fuel cell powered isolated full bridge dc-dc boost converter. As the input voltage of such converter is inherently low with very high dc and ripple currents and since the EMI limits also does not change...... for such application, it calls for a carefully optimized EMI filter which is designed and implemented in this work. Moreover, the negative input impedance of the regulated converter is extremely low; well-designed filter damping branch is also included. Differential mode noise is analyzed analytically for a 3KW/400V...... boost converter. Simulation and experimental results are recorded and published. © 2013 IEEE....

  15. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  16. On the use of EMI for the assessment of dental implant stability

    Science.gov (United States)

    La Malfa Ribolla, Emma; Rizzo, Piervincenzo; Gulizzi, Vincenzo

    2014-03-01

    The achievement and the maintenance of dental implant stability are prerequisites for the long-term success of the osseointegration process. Since implant stability occurs at different stages, it is clinically required to monitor an implant over time, i.e. between the surgery and the placement of the artificial tooth. In this framework, non-invasive tests able to assess the degree of osseointegration are necessary. In this paper, the electromechanical impedance (EMI) method is proposed to monitor the stability of dental implants. A 3D finite element model of a piezoceramic transducer (PZT) bonded to a dental implant placed into the bone was created, considering the presence of a bone-implant interface subjected to Young's modulus change. The numerical model was validated experimentally by testing bovine bone samples. The EMI response of a PZT, bonded to the abutment screwed to implants inserted to the bone, was measured. To simulate the osseointegration process a pulp canal sealer was used to secure the implant to the bone. It was found that the PZT's admittance is sensitive to the stiffness variation of the bone-implant interface. The results show that EMIbased method is able (i) to evaluate the material properties around the implant, and (ii) to promote a novel non-invasive monitoring of dental implant surgical procedure.

  17. Electromagnetic interference (EMI) transparent shielding of reduced graphene oxide (RGO) interleaved structure fabricated by electrophoretic deposition.

    Science.gov (United States)

    Kim, Sanghoon; Oh, Joon-Suk; Kim, Myeong-Gi; Jang, Woojin; Wang, Mei; Kim, Youngjun; Seo, Hee Won; Kim, Ye Chan; Lee, Jun-Ho; Lee, Youngkwan; Nam, Jae-Do

    2014-10-22

    Here we introduce the electromagnetic shielding effectiveness (SE) of reduced graphene oxide (RGO) sheets interleaved between polyetherimide (PEI) films fabricated by electrophoretic deposition (EPD). Incorporating only 0.66 vol % of RGO, the developed PEI/RGO composite films exhibited an electromagnetic interference shielding effectiveness (EMI SE) at 6.37 dB corresponding to ∼50% shielding of incident waves. Excellent flexibility and optical transparency up to 62% of visible light was demonstrated. It was achieved by placing the RGO sheets in the localized area as a thin film (ca. 20 nm in thickness) between the PEI films (ca. 2 μm) to be an interleaved and alternating structure. This unique interleaved structure without any delamination areas was fabricated by a successive application of cathodic and anodic EPD of both RGO and PEI layers. The EPD fabrication process was ensured by an alternating deposition of the quarternized-PEI drops and RGO, each taking positive and negative charges, respectively, in the water medium. We believe that the developed facile fabrication method of RGO interleaved structure with such low volume fraction has great potential to be used as a transparent EMI shielding material. PMID:25238628

  18. Graphene nanoribbon-PVA composite as EMI shielding material in the X band

    Science.gov (United States)

    Joshi, Anupama; Bajaj, Anil; Singh, Rajvinder; Alegaonkar, P. S.; Balasubramanian, K.; Datar, Suwarna

    2013-11-01

    A very thin graphene nanoribbon/polyvinyl alcohol (GNR/PVA) composite film has been developed which is light weight and requires a very low concentration of filler to achieve electromagnetic interference (EMI) shielding as high as 60 dB in the X band. Atomic force microscope studies show very well conjugated filler concentration in the PVA matrix for varying concentrations of GNR supported by Raman spectroscopy data. The films show 14 orders of increase in conductivity with a GNR concentration of 0.0075 wt% in PVA. This is possible because of the interconnected GNR network providing a very low percolation threshold as observed from the electrical measurements. Local density of states study of GNR using scanning tunnelling spectroscopy shows the presence of localized states near the Fermi energy. There are multiple advantages of GNR as an EMI shielding material in a polymer matrix. It has good dispersion in water, the conductive network in the composite shows very high electrical conductivity for a very low concentration of GNR and the presence of localized density of states near Fermi energy provides the spin states required for the absorbance of radiation energy in the X band.

  19. Research of EMI Rectification for Profibus-DP System%Profibus-DP系统EMI问题研究

    Institute of Scientific and Technical Information of China (English)

    侯金华; 琚长江

    2009-01-01

    The EMI problem of Profibus-DP system was studied.Aimming at an EMI test example of Profibus-DP device,the problem Was proposed and analyzed,and the improvement measure Was given.The improvement scheme is feasible and make Profibus-DP device pass the test.%研究了Profibus-DP系统的EMI问题.针对一个Profibus-DP设备的EMI测试实例,提出问题进行分析,并提出了改进措施.该改进方案经济可行,使Profibus-DP设备顺利通过了试验.

  20. Proceedings of the XVIIth International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS2015), Grand Rapids, MI, U.S.A., 11-15 May 2015

    Science.gov (United States)

    Bollen, Georg; Mittig, Wolfgang; Morrissey, Dave; Schwarz, Stefan; Villari, Antonio

    2016-06-01

    The 17th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS-2015) was held in Grand Rapids, Michigan, in the United States, from May 11th to 15th, 2015. The EMIS-2015 conference was hosted by Michigan State University. The present volume contains the proceedings of the event.

  1. Characterisation of bio-aerosols during dust storm period in N-NW India

    Science.gov (United States)

    Yadav, Sudesh; Chauhan, M. S.; Sharma, Anupam

    Bio-investigations for pollen and spores were performed on dry free-fall dust and PM 10 aerosol samples, collected from three different locations separated by a distance of 600 km, situated in dust storm hit region of N-NW India. Presence of pollen of trees namely Prosopis ( Prosopis juliflora and Prosopis cinearia), Acacia, Syzygium, Pinus, Cedrus, Holoptelea and shrubs namely Ziziphus, Ricinus, Ephedra and members of Fabaceae, Oleaceae families was recorded but with varying proportions in the samples of different locations. Poaceae, Chenopodiaceae/Amaranthaceae, Caryophyllaceae, Brassicaceae and Cyperaceae (sedges) were some of the herb pollen identified in the samples. Among the fungal spores Nigrospora was seen in almost all samples. Nigrospora is a well known allergen and causes health problems. The concentration of trees and shrubs increases in the windward direction just as the climate changes from hot arid to semiarid. The higher frequency of grasses (Poaceae) or herbs could either be a result of the presence of these herbs in the sampling area and hence the higher production of pollen/spores or due to the resuspension from the exposed surface by the high-intensity winds. But we cannot ascertain the exact process at this stage. The overall similarity in the pollen and spore assemblage in our dust samples indicates a common connection or source(s) to the dust in this region. Presence of the pollen of the species of Himalayan origin in our entire samples strongly point towards a Himalayan connection, could be direct or indirect, to the bioaerosols and hence dust in N-NW India. In order to understand the transport path and processes involved therein, present study needs further extension with more number of samples and with reference to meteorological parameters.

  2. Microorganisms in bioaerosol emissions from wastewater treatment plants during summer at a Mediterranean site.

    Science.gov (United States)

    Karra, Styliani; Katsivela, Eleftheria

    2007-03-01

    Measurements were conducted at a Mediterranean site (latitude 35 degrees 31' north and longitude 24 degrees 03' east) during summer, to study the concentration of microorganisms emitted from a wastewater treatment plant under intensive solar radiation (520-840 W/m2) and at elevated air temperatures (25-31 degrees C). Air samples were taken with the Air Sampler MAS 100 (Merck) at each stage of an activated-sludge wastewater treatment (pretreatment, primary settling tanks, aeration tanks, secondary settling tanks, chlorination, and sludge processors). Cultivation methods based on the viable counts of mesophilic heterotrophic bacteria, as well as of indicator microorganisms of faecal contamination (total and faecal coliforms and enterococci), and fungi were performed. During air sampling, temperature, solar radiation, relative humidity and wind speed were measured. The highest concentrations of airborne microorganisms were observed at the aerated grit removal of wastewater at the pretreatment stage. A gradual decrease of bioaerosol emissions was observed during the advanced wastewater treatment from the pretreatment to the primary, secondary and tertiary treatment (97.4% decrease of mesophilic heterotrophic bacteria, and 100% decrease of total coliforms, faecal coliforms and enterococci), 95.8% decrease of fungi. The concentration of the airborne microorganisms at the secondary and tertiary treatment of the wastewater was lower than in the outdoor control. At the same time, the reduction of the microbial load at the waste sludge processors was 19.7% for the mesophilic heterotrophic bacteria, 99.4% for the total coliforms, and 100% for the faecal coliforms and the enterococci, 84.2% for the fungi. The current study concludes that the intensive solar radiation, together with high ambient temperatures, as well as optimal wastewater treatment are the most important factors for low numbers of microbes in the air.

  3. Bioaerosol emissions and detection of airborne antibiotic resistance genes from a wastewater treatment plant

    Science.gov (United States)

    Li, Jing; Zhou, Liantong; Zhang, Xiangyu; Xu, Caijia; Dong, Liming; Yao, Maosheng

    2016-01-01

    Air samples from twelve sampling sites (including seven intra-plant sites, one upwind site and four downwind sites) from a wastewater treatment plant (WWTP) in Beijing were collected using a Reuter Centrifugal Sampler High Flow (RCS); and their microbial fractions were studied using culturing and high throughput gene sequence. In addition, the viable (fluorescent) bioaerosol concentrations for 7 intra-plant sites were also monitored for 30 min each using an ultraviolet aerodynamic particle sizer (UV-APS). Both air and water samples collected from the plant were investigated for possible bacterial antibiotic resistance genes and integrons using polymerase chain reaction (PCR) coupled with gel electrophoresis. The results showed that the air near sludge thickening basin was detected to have the highest level of culturable bacterial aerosols (up to 1697 CFU/m3) and fungal aerosols (up to 930 CFU/m3). For most sampling sites, fluorescent peaks were observed at around 3-4 μm, except the office building with a peak at 1.5 μm, with a number concentration level up to 1233-6533 Particles/m3. About 300 unique bacterial species, including human opportunistic pathogens, such as Comamonas Testosteroni and Moraxella Osloensis, were detected from the air samples collected over the biological reaction basin. In addition, we have detected the sul2 gene resistant to cotrimoxazole (also known as septra, bactrim and TMP-SMX) and class 1 integrase gene from the air samples collected from the screen room and the biological reaction basin. Overall, the screen room, sludge thickening basin and biological reaction basin imposed significant microbial exposure risks, including those from airborne antibiotic resistance genes.

  4. Assessment the Bio-Aerosols Type and Concentration in Various Wards of Valiasr Hospital, Khorramshahr during 2011

    Directory of Open Access Journals (Sweden)

    Zohreh Sadeghi Hasanvand1,

    2013-09-01

    Results: The highest average concentration of pollution occurred in Infectious Ward (238.51 CFU/ M3 in spring and 167.02 CFU/M3 in autumn and the lowest one was related to the CCU, where showed no fungi growth during both seasons. Despite the environment sterilization, the highest percentage of fungi (Aspergillus Niger and yeast observed in the hospital air was 42.45 percent in spring and 44.26 percent in autumn respectively. Moreover, Staphillus Epidermithis (25.93 percentand gram-positive bacillus were the highest percentage of bacteria identified in air samples. Conclusion: From the findings of this study, it can be concluded that the concentration of bio-aerosols in different hospital wards expect in CCU was more than recommended and similar studies and in terms of species was similar to other studies. Therefore, the hospital authority is recommended to reduce the amount of the pathogenic and environmental bio-aerosols through controlling individual traffic, changing the disinfectants and their applying procedure on the wards surface, establishing standard and suitable ventilation systems.

  5. Preventive measures to reduce bioaerosol exposure during refuse collection: results of field studies in the real-life situation.

    Science.gov (United States)

    Neumann, H-D; Becker, G; Lohmeyer, M; Mathys, W

    2005-04-01

    The aim of the present research project was to investigate and evaluate technical and organisational measures targeted at bioaerosol reduction during the refuse collection and to determine the exposure of refuse collectors to dust, fungi and endotoxins in an on-the-job situation with different vehicle technologies and states of hygiene. The following technical factors were found to influence the bioaerosol concentration at the refuse collector's workplace: compaction method, lifting device control, rave rail height, hopper depth, design of intake area and dust interception. For instance, notably higher total fungal counts were recorded with rotating drum compaction than with packer plate compaction. A hinged lid closure at the lifting device in conjunction with a suction unit induced a positive effect. In addition, the automatic lifting system had a positive influence on rear-end loaders, as did loading operation control from the closed driver's cab on side loaders. Regular internal and external high-pressure cleaning of the lifting device at intervals of not more than 14 days is recommended as a basic rule for vehicle hygiene. PMID:15833237

  6. Atmospheric bioaerosols originating from Adélie penguins (Pygoscelis adeliae): Ecological observations of airborne bacteria at Hukuro Cove, Langhovde, Antarctica

    Science.gov (United States)

    Kobayashi, Fumihisa; Maki, Teruya; Kakikawa, Makiko; Noda, Takuji; Mitamura, Hiromichi; Takahashi, Akinori; Imura, Satoshi; Iwasaka, Yasunobu

    2016-03-01

    The relationship between atmospheric bioaerosols and ecosystems is currently of global importance. Antarctica has an extreme climate, meaning that ecosystem behavior in this region is relatively simple. Direct sampling of atmospheric bioaerosols was performed at an Adélie penguin (Pygoscelis adeliae) colony at Hukuro Cove, Langhovde, Antarctica on 22 January 2013. The aim of the sampling was to reveal the effect of the penguins on the Antarctic ecosystem within the atmospheric bioaerosols. Samples were bio-analyzed using a next-generation sequencing method. Biomass concentrations of Bacilli-class bacteria were 19.4 times higher when sampled leeward of the penguin colony compared with windward sampling. The source of these bacteria was the feces of the penguins. Predicted atmospheric trajectories indicate that the bacteria disperse towards the Southern Ocean. The largest biomass concentration in the windward bacteria was of the Gammaproteobacteria class, which decreased markedly with distance through the penguin colony, being deposited on soil, surface water, and ocean. It is concluded that bioaerosols and ecosystems near the penguin colony strongly influence each other.

  7. Biophysical analysis of bacterial and viral systems. A shock tube study of bio-aerosols and a correlated AFM/nanosims investigation of vaccinia virus

    Energy Technology Data Exchange (ETDEWEB)

    Gates, Sean Damien [Stanford Univ., CA (United States)

    2013-05-01

    The work presented herein is concerned with the development of biophysical methodology designed to address pertinent questions regarding the behavior and structure of select pathogenic agents. Two distinct studies are documented: a shock tube analysis of endospore-laden bio-aerosols and a correlated AFM/NanoSIMS study of the structure of vaccinia virus.

  8. ENVIRONMENTAL TECHNOLOGY VERIFICATION, TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS, FILTRATION GROUP, AEROSTAR "C-SERIES" POLYESTER PANEL FILTER

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the AeroStar "C-Series" Polyester Panel Filter air filter for dust and bioaerosol filtration manufactured by Filtration Group. The pressure drop across the filter was 126 Pa clean and 267...

  9. Functionalized polypropylenes as efficient dispersing agents for carbon nanotubes in a polypropylene matrix; application to electromagnetic interference (EMI) absorber materials

    OpenAIRE

    Thomassin, Jean-Michel; Huynen, Isabelle; Jérôme, Robert; Detrembleur, Christophe

    2010-01-01

    Carbon nanotubes (CNTs) have been dispersed within polypropylene with the purpose to prepare electromagnetic interference (EMI) absorbers. In order to limit the reflectivity of the electromagnetic waves at the interface of the materials while achieving good absorbing properties, the CNTs concentration must be kept low (

  10. Dynamic EMI sensor platform for digital geophysical mapping and automated clutter rejection for CONUS and OCONUS applications

    Science.gov (United States)

    Laudato, Stephen J.; Schultz, Gregory; Keranen, Joe; Miller, Jonathan S.

    2016-05-01

    The implementation of new advanced electromagnetic induction (EMI) sensor surveys at sites containing unexploded ordnance (UXO) and explosive remnants of war (ERW) is an effective method for accurate mapping and for discriminating clutter from targets of interest. We present development and integration of a next generation advanced EMI sensor onto a cart-based sensing platform to combine the mapping capability of previous digital geophysical survey instruments with the high-resolution discrimination capability of advanced characterization arrays. The EMI sensor employs a multi-axis receiver configuration to produce data sufficient for anomaly discrimination. We discuss platform design and development, data acquisition and post-processing software development, and results from field tests demonstrating the detection and discrimination capability of the cart-based system. Platform development and design focused on navigation and EMI sensor integration onto a custom, low-noise, metal-free platform. Data acquisition is via an Android application with emphasis on ease-of-use and real-time quality control (QC) of collected data. Post-processing methods emphasize QC, inversion-based anomaly location estimation, and automated or supervised polarizability-based discrimination methods to produce a prioritized dig list. Integration of the detection, clutter rejection and QC methods into the post-processing software module reduces the time required between sensor data collection and generation of a prioritized dig list. System concept of operations (CONOPs), data collection, QC, data processing procedures, and performance against various clutter objects and targets of interest will also be discussed.

  11. Designing Tone Reservation PAR Reduction

    Directory of Open Access Journals (Sweden)

    Johansson Albin

    2006-01-01

    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  12. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes

    OpenAIRE

    Lioy, Virginia S.; Andrea Volante; Nora E Soberón; Rudi Lurz; Silvia Ayora; Alonso, Juan C.

    2015-01-01

    In Firmicutes, small homodimeric ParA-like (δ2) and ParB-like (ω2) proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (ω:YFP)2 binding to parS facilitates plasmid clustering in the cytosol. (δ:GFP)2 requires ATP binding but not hydrolysis to localize onto the cell's nucleoid as a fluorescent cloud. The interaction of (δ:CFP)2 or δ2 bound to the nucleoid with (ω:YFP)2 foci f...

  13. Determination of the Path Loss from Passenger Electronic Devices to Radio Altimeter with Additional EMI Test

    Science.gov (United States)

    Schüür, J.; Nunes, R. R.

    2012-05-01

    Emitters of current and future wireless ultra wideband technology (UWB) inside the cabin should not interfere with any aircraft system. Especially the radio altimeter (RA) system using antennas mounted outside the fuselage is potentially sensitive to UWB devices in the frequency range between 4.1 and 4.8 GHz. The measurement of the interference path loss (IPL) to the RA is therefore of interest and is presented for different aircraft. The need of a high dynamic setup with low parasitic coupling in the IPL measurement is stressed. In addition, electromagnetic interference (EMI) tests with different transmitted signals are made, showing that the susceptibility of the RA system actually increases with UWB modulation.

  14. Hexavalent Chrome Free Coatings for Electronics Electromagnetic Interference (EMI) Shielding Effectiveness (SE) Interim Test Report

    Science.gov (United States)

    Kessel, Kurt R.

    2015-01-01

    Test specimen configuration was provided by Parker Chomerics. The EMI gasket used in this project was Cho-Seal 6503E. Black oxide alloy steel socket head bolts were used to hold the plates together. Non-conductive spacers were used to control the amount of compression on the gaskets. The following test fixture specifications were provided by Parker Chomerics. The CHO-TP09 test plate sets selected for this project consist of two aluminum plates manufactured to the specifications detailed in CHO­-TP09. The first plate, referred to as the test frame, is illustrated in Figure 1. The test frame is designed with a cutout in the center and two alternating bolt patterns. One pattern is used to bolt the test frame to the corresponding test cover plate (Figure 2), forming a test plate set. The second pattern accepts the hardware used to mount the fully assembled test plate set to the main adapter plate (Figure 3).

  15. Hexavalent Chrome Free Coatings for Electronics; Electromagnetic Interference (EMI) Shielding Effectiveness (SE)

    Science.gov (United States)

    Kessel, Kurt R.

    2014-01-01

    The purpose of this testing is to determine the suitability of trivalent chromium conversion coatings that meet the requirements of MIL-DTL-5541, Type II, for use in applications where high-frequency electrical performance is important. This project will evaluate the ability of coated aluminum to form adequate EMI seals. Testing will assess performance of the trivalent chromium coatings against the known control hexavalent chromium MIL-DTL-5541 Type I Class 3 before and after they have been exposed to a set of environmental conditions. Performance will be assessed by evaluating shielding effectiveness (SE) test data from a variety of test samples comprised of different aluminum types and/or conversion coatings.

  16. Efficient stochastic EMC/EMI analysis using HDMR-generated surrogate models

    KAUST Repository

    Yücel, Abdulkadir C.

    2011-08-01

    Stochastic methods have been used extensively to quantify effects due to uncertainty in system parameters (e.g. material, geometrical, and electrical constants) and/or excitation on observables pertinent to electromagnetic compatibility and interference (EMC/EMI) analysis (e.g. voltages across mission-critical circuit elements) [1]. In recent years, stochastic collocation (SC) methods, especially those leveraging generalized polynomial chaos (gPC) expansions, have received significant attention [2, 3]. SC-gPC methods probe surrogate models (i.e. compact polynomial input-output representations) to statistically characterize observables. They are nonintrusive, that is they use existing deterministic simulators, and often cost only a fraction of direct Monte-Carlo (MC) methods. Unfortunately, SC-gPC-generated surrogate models often lack accuracy (i) when the number of uncertain/random system variables is large and/or (ii) when the observables exhibit rapid variations. © 2011 IEEE.

  17. A high power EMI sensor for detecting and classifying small and deep targets

    Science.gov (United States)

    Shubitidze, F.; Barrowes, B. E.; Wang, Yinlin; Shamatava, Irma; Sigman, J. B.; O'Neil, K.; Steinhurst, Daniel A.

    2016-05-01

    Detecting and classifying small (i.e., with calibers ranging from 20 to 60 mm) and deep targets (burial depth more than 11 times targets diameter) is still a challenging problem using current advanced EMI sensors and signal processing approaches. In order to overcome this problem, the standard time-domain NRL TEMTADS 2x2 electromagnetic induction (EMI) instrument is updated. Namely, the NRL TEMTADS 2x2 system's transmitter electronics is modified to increase transmitter (Tx) currents from 6 Amperes to 14 Amperes. The instrument has a Tx array with four coplanar square coils, together with four tri-axial receivers (Rx) placed at the center of each Tx. Each Rx cube contains three orthogonal coils and thus registers all three vector components of the impinging signals. The Tx coils, with transmitter currents of ~14 A, illuminate a buried target, and the target responses are collected with a 500 kHz sample rate after turn off of the excitation pulse. The system operates in both static (cued) and dynamic modes. For cued mode, the raw decay measurements are grouped into 121 logarithmically-spaced "gates" whose center times range from 25 μs to 24.35 ms with 5% widths. The sensor is placed on a cart which provides a sensor-to-ground offset of 20 cm or less. In this paper, studies for APG Calibration, Blind, and Small Munitions Grids are presented and analyzed. The areas are arranged in grids of test cells and the cell center positions are known. Each target position is flagged with a non-metallic pin flag using cm-level GPS. The sensor is positioned over each target in turn. With the system positioned over the target, each Tx is activated sequentially and during off the Tx current, all four Rx record data. The capabilities of this sensor platform is rigorously investigated for UXO classification at APG blind and small munitions grids.

  18. EMI/RFI and Power Surge Withstand Guidance for the U.S. Nuclear Regulatory Commission

    International Nuclear Information System (INIS)

    This paper discusses the regulatory guidance implemented by U.S. NRC for minimizing malfunctions and upsets in safety-related instrumentation and control (I and C) systems in nuclear power plants caused by electromagnetic interference (EMI), radio-frequency interference (RFI), and power surges. The engineering design, installation, and testing practices deemed acceptable to U.S. NRC are described in Regulatory Guide (RG) 1.180, 'Guidelines for Evaluating Electromagnetic and Radio-Frequency in Safety-Related Instrumentation and Control Systems' (January 2000) and in a Safety Evaluation Report (SER) endorsing EPRI TR-102323, 'Guidelines for Electromagnetic Interference Testing in Power Plants', (April 1996). These engineering practices provide a well-established, systematic approach for ensuring electromagnetic compatibility (EMC) and surge withstand capability (SWC). The issuance of RG-1.180 and the EPRI TR-102323 SER by U.S. NRC has resulted in clear guidance on the practices necessary for a comprehensive EMC program. Both documents represent guidance that is acceptable to U.S. NRC. These practices are presently being applied to analog, digital, and hybrid (i.e., combined analog and digital electronics) safety-related I and C equipment. The concurrence within the nuclear industry is that approval cycles have been significantly reduced, EMC awareness has been heightened, and the number of EMC-related occurrences has been reduced. Adherence to the guidance in RG-1.180 and the SER for safety-related I and C systems has contributed to the assurance that structures, systems, and components important to safety are compatible with the environmental conditions associated with nuclear power plants. Consensus standards were endorsed that cover design, installation, EMI/RFI, and SWC practices. Test methods have been provided that contribute to a well established, systematic approach for ensuring EMC. Operating envelopes that have been confirmed with actual measurement data in

  19. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

    DEFF Research Database (Denmark)

    Hsu, Jerry Y; Reimann, Julie D R; Sørensen, Claus S;

    2002-01-01

    Emi1 promotes mitotic entry in Xenopus laevis embryos by inhibiting the APC(Cdc20) ubiquitination complex to allow accumulation of cyclin B. We show here that human Emi1 (hEmi1) functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC(Cdh1) complex....... At the G1-S transition, hEmi1 is transcriptionally induced by the E2F transcription factor, much like cyclin A. hEmi1 overexpression accelerates S phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of hEmi1...... through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. These data suggest that E2F can activate both transcription of cyclin A and the hEmi1-dependent stabilization of APC(Cdh1) targets, such as cyclin A, to promote S phase entry....

  20. Discriminating Bio-aerosols from Non-Bio-aerosols in Real-Time by Pump-Probe Spectroscopy

    Science.gov (United States)

    Sousa, Gustavo; Gaulier, Geoffrey; Bonacina, Luigi; Wolf, Jean-Pierre

    2016-09-01

    The optical identification of bioaerosols in the atmosphere and its discrimination against combustion related particles is a major issue for real-time, field compatible instruments. In the present paper, we show that by embedding advanced pump-probe depletion spectroscopy schemes in a portable instrument, it is possible to discriminate amino acid containing airborne particles (bacteria, humic particles, etc.) from poly-cyclic aromatic hydrocarbon containing combustion particles (Diesel droplets, soot, vehicle exhausts) with high selectivity. Our real-time, multi-modal device provides, in addition to the pump-probe depletion information, fluorescence spectra (over 32 channels), fluorescence lifetime and Mie scattering patterns of each individually flowing particle in the probed air.

  1. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  2. Radiation dose to the head, and particularly to the lens of the eye, during axial tomography with the EMI scanner

    International Nuclear Information System (INIS)

    Radiation dose to the lens of the eye was estimated using thermoluminescence and film dosimetry on patients undergoing computerised axial skull tomography with the EMI scanner, and also on various phantoms. The dose decreases from the lateral margin of the right eye to the lateral margin of the left eye. During conventional three-layer tomography, maximal exposure of the eye is about 0.6 R (1.55 x 10-4 C x kg-1), produced entirely by scatter. Direct irradiation of the plane of the orbits produces a maximal exposure rate of 3 R (7.7 x 10-4 C x kg-1). Maximal dose to the head depends on skull size and is about 4 R (approximately 10-3 C x kg-1). The local dose dependence of the eyes was confirmed theoretically by drawing up a computer programme, and was related to the method used by the EMI scanner. (orig.)

  3. ParB spreading requires DNA bridging

    OpenAIRE

    Graham, Thomas G. W.; Wang, Xindan; Song, Dan; Etson, Candice M.; van Oijen, Antoine M.; Rudner, David Z.; Loparo, Joseph J.

    2014-01-01

    The bacterial parABS system is employed for plasmid partitioning and chromosome segregation. ParB binds to parS sites and associates with broad regions of adjacent DNA, a phenomenon known as spreading. However, the molecular basis for spreading is unknown. Using single-molecule approaches, Graham et al. demonstrate DNA bridging by B. subtilis ParB (Spo0J). Spo0J mutations that disrupt DNA bridging lead to defective spreading and SMC condensin complex recruitment. This study suggests a novel, ...

  4. ELECTROLESS NICKEL DEPOSITION ON FRAXINUS MANDSHURICA VENEER MODIFIED WITH APTHS FOR EMI SHIELDING

    Directory of Open Access Journals (Sweden)

    Haibing Liu

    2010-08-01

    Full Text Available Electroless nickel deposition was carried out on Fraxinus mandshurica veneers for EMI shielding under a new activation process. In the process, Pd(II was absorbed on the surface of veneers modified with γ-aminopropyltrihydroxysilane (APTHS obtained from the hydrolysis of γ-aminopropyltriethoxysilane (APTES. After the reduction, electroless plating was successfully initiated, and Ni-P coating was deposited on the veneers. The activation process and resulting coating were characterized by XPS, SEM-EDS, and XRD. The metal deposition, surface resistivity, and electromagnetic shielding effectiveness were measured. XPS analysis proved that Pd(II was bonded to the amino group of APTHS and reduced to Pd(0. The coating was continuous, uniform, and compact. It consisted of 97.4 wt% nickel and 2.6 wt% phosphorus. XRD analysis showed that the coating was crystalline, which was related to the low phosphorus content. The plated Fraxinus mandshurica veneers exhibit good electro-conductivity with surface resistivity of 0.21Ω•cm-2 and higher electromagnetic shielding effectiveness of over 50dB in frequencies from 10 MHz to 1.5 GHz.

  5. An h-adaptive stochastic collocation method for stochastic EMC/EMI analysis

    KAUST Repository

    Yücel, Abdulkadir C.

    2010-07-01

    The analysis of electromagnetic compatibility and interference (EMC/EMI) phenomena is often fraught by randomness in a system\\'s excitation (e.g., the amplitude, phase, and location of internal noise sources) or configuration (e.g., the routing of cables, the placement of electronic systems, component specifications, etc.). To bound the probability of system malfunction, fast and accurate techniques to quantify the uncertainty in system observables (e.g., voltages across mission-critical circuit elements) are called for. Recently proposed stochastic frameworks [1-2] combine deterministic electromagnetic (EM) simulators with stochastic collocation (SC) methods that approximate system observables using generalized polynomial chaos expansion (gPC) [3] (viz. orthogonal polynomials spanning the entire random domain) to estimate their statistical moments and probability density functions (pdfs). When constructing gPC expansions, the EM simulator is used solely to evaluate system observables at collocation points prescribed by the SC-gPC scheme. The frameworks in [1-2] therefore are non-intrusive and straightforward to implement. That said, they become inefficient and inaccurate for system observables that vary rapidly or are discontinuous in the random variables (as their representations may require very high-order polynomials). © 2010 IEEE.

  6. Precise Estimation of Cellular Radio Electromagnetic Field in Elevators and EMI Impact on Implantable Cardiac Pacemakers

    Science.gov (United States)

    Harris, Louis-Ray; Hikage, Takashi; Nojima, Toshio

    The purpose of this paper is to investigate the possible impact of cellular phones' signals on implantable cardiac pacemakers in elevators. This is achieved by carrying out precise numerical simulations based on the Finite-Difference-Time-Domain method to examine the electromagnetic fields in elevator models. In order to examine the realistic and complicated situations where humans are present in the elevator, we apply the realistic homogeneous human phantom and cellular radios operating in the frequency bands 800MHz, 1.5GHz and 2GHz. These computed results of field strength inside the elevator are compared with a certain reference level determined from the experimentally obtained maximum interference distance of implantable cardiac pacemakers. This enables us to carry out a quantitative evaluation of the EMI risk to pacemakers by cellular radio transmission. The results show that for the case when up to 5 mobile radio users are present in the elevator model used, there is no likelihood of pacemaker malfunction for the frequency bands 800MHz, 1.5GHz and 2GHz.

  7. Hexavalent Chrome Free Coatings for Electronics: Electromagnetic Interference (EMI) Shielding Effectiveness (SE)

    Science.gov (United States)

    Kessel, Kurt R.

    2016-01-01

    Determine the suitability of trivalent chromium conversion coatings that meet the requirements of MIL-DTL-5541, Type II, for use in applications where high-frequency electrical performance is important. Evaluate the ability of hexavalent chrome free pretreated aluminum to form adequate EMI seals, and maintain that seal while being subjected to harsh environmental conditions. Assess the performance of trivalent chromium pretreatments against a known control hexavalent chrome pretreatment before and after they have been exposed to a set of environmental conditions. It is known that environmental testing causes a decrease in shielding effectiveness when hexavalent chrome pretreatments are used (Alodine 1200s). Need to determine how shielding effectiveness will be affected with the use of hexavalent chrome free pretreatments. Performance will be assessed by evaluating shielding effectiveness (SE) test data from a variety of test samples comprised of different aluminum types and/or conversion coatings. The formation of corrosion will be evaluated between the mating surfaces and gasket to assess the corrosion resistant properties of the pretreatments, comparing the hexavalent control to the hexavalent chrome free pretreatments.

  8. Digital Mapping of Soil Salinity and Crop Yield across a Coastal Agricultural Landscape Using Repeated Electromagnetic Induction (EMI) Surveys.

    Science.gov (United States)

    Yao, Rongjiang; Yang, Jingsong; Wu, Danhua; Xie, Wenping; Gao, Peng; Jin, Wenhui

    2016-01-01

    Reliable and real-time information on soil and crop properties is important for the development of management practices in accordance with the requirements of a specific soil and crop within individual field units. This is particularly the case in salt-affected agricultural landscape where managing the spatial variability of soil salinity is essential to minimize salinization and maximize crop output. The primary objectives were to use linear mixed-effects model for soil salinity and crop yield calibration with horizontal and vertical electromagnetic induction (EMI) measurements as ancillary data, to characterize the spatial distribution of soil salinity and crop yield and to verify the accuracy of spatial estimation. Horizontal and vertical EMI (type EM38) measurements at 252 locations were made during each survey, and root zone soil samples and crop samples at 64 sampling sites were collected. This work was periodically conducted on eight dates from June 2012 to May 2013 in a coastal salt-affected mud farmland. Multiple linear regression (MLR) and restricted maximum likelihood (REML) were applied to calibrate root zone soil salinity (ECe) and crop annual output (CAO) using ancillary data, and spatial distribution of soil ECe and CAO was generated using digital soil mapping (DSM) and the precision of spatial estimation was examined using the collected meteorological and groundwater data. Results indicated that a reduced model with EMh as a predictor was satisfactory for root zone ECe calibration, whereas a full model with both EMh and EMv as predictors met the requirement of CAO calibration. The obtained distribution maps of ECe showed consistency with those of EMI measurements at the corresponding time, and the spatial distribution of CAO generated from ancillary data showed agreement with that derived from raw crop data. Statistics of jackknifing procedure confirmed that the spatial estimation of ECe and CAO exhibited reliability and high accuracy. A general

  9. Extension of the sorting instructions for household plastic packaging and changes in exposure to bioaerosols at materials recovery facilities.

    Science.gov (United States)

    Schlosser, O; Déportes, I Z; Facon, B; Fromont, E

    2015-12-01

    The aim of this study was to assess how extending the sorting instructions for plastic packaging would affect the exposure of workers working at materials recovery facility (MRF) to dust, endotoxins, fungi and bacteria, taking into consideration other factors that could have an influence on this exposure. Personal sampling was carried out at four MRFs during six sampling campaigns at each facility, both in sorting rooms and when the workers were involved in "mobile tasks" away from the rooms. The data was analysed by describing the extension of sorting instructions both using a qualitative variable (after vs before) and using data for the pots and trays recycling stream, including or excluding plastic film. Overall, before the extension of the sorting guidelines, the geometric mean of personal exposure levels in sorting rooms was 0.3mg/m(3) for dust, 27.7 EU/m(3) for endotoxins, 13,000 CFU/m(3) for fungi and 1800 CFU/m(3) for bacteria. When workers were involved in mobile tasks away from the rooms, these averages were 0.5mg/m(3), 25.7 EU/m(3), 28,000 CFU/m(3) and 5100 CFU/m(3) respectively.The application by households of instructions to include pots, trays and film with other recyclable plastic packaging led to an increase in exposure to endotoxins, fungi and bacteria at MRFs. For an increase of 0.5 kg per inhabitant per year in the pots, trays and film recycling stream, exposure in sorting rooms rose by a factor of 1.4-2.2, depending on the biological agent. Exposure during mobile tasks increased by a factor of 3.0-3.6. The age of the waste amplified the effect of the extension of sorting instructions on exposure to fungi, bacteria and endotoxins. Factors that had a significant influence on the exposure of workers to dust and/or bioaerosols included the presence of paper, newspapers and magazines in the sorted waste, the order in which incoming waste was treated and the quality of the ventilation system in the sorting rooms. The levels of exposure observed in

  10. Extension of the sorting instructions for household plastic packaging and changes in exposure to bioaerosols at materials recovery facilities.

    Science.gov (United States)

    Schlosser, O; Déportes, I Z; Facon, B; Fromont, E

    2015-12-01

    The aim of this study was to assess how extending the sorting instructions for plastic packaging would affect the exposure of workers working at materials recovery facility (MRF) to dust, endotoxins, fungi and bacteria, taking into consideration other factors that could have an influence on this exposure. Personal sampling was carried out at four MRFs during six sampling campaigns at each facility, both in sorting rooms and when the workers were involved in "mobile tasks" away from the rooms. The data was analysed by describing the extension of sorting instructions both using a qualitative variable (after vs before) and using data for the pots and trays recycling stream, including or excluding plastic film. Overall, before the extension of the sorting guidelines, the geometric mean of personal exposure levels in sorting rooms was 0.3mg/m(3) for dust, 27.7 EU/m(3) for endotoxins, 13,000 CFU/m(3) for fungi and 1800 CFU/m(3) for bacteria. When workers were involved in mobile tasks away from the rooms, these averages were 0.5mg/m(3), 25.7 EU/m(3), 28,000 CFU/m(3) and 5100 CFU/m(3) respectively.The application by households of instructions to include pots, trays and film with other recyclable plastic packaging led to an increase in exposure to endotoxins, fungi and bacteria at MRFs. For an increase of 0.5 kg per inhabitant per year in the pots, trays and film recycling stream, exposure in sorting rooms rose by a factor of 1.4-2.2, depending on the biological agent. Exposure during mobile tasks increased by a factor of 3.0-3.6. The age of the waste amplified the effect of the extension of sorting instructions on exposure to fungi, bacteria and endotoxins. Factors that had a significant influence on the exposure of workers to dust and/or bioaerosols included the presence of paper, newspapers and magazines in the sorted waste, the order in which incoming waste was treated and the quality of the ventilation system in the sorting rooms. The levels of exposure observed in

  11. Applicability of a modified MCE filter method with Button Inhalable Sampler for monitoring personal bioaerosol inhalation exposure.

    Science.gov (United States)

    Xu, Zhenqiang; Xu, Hong; Yao, Maosheng

    2013-05-01

    was found not to substantially alter the species richness. Regardless of the sampling methods, more species richness was observed in the outdoor environment than the indoor environment. This study described a new personal bioaerosol exposure assessment protocol, and it was demonstrated applicable in monitoring the personal bioaerosol exposure in replace of an Andersen-type impactor.

  12. Performance testing of passive autocatalytic recombiners (PARs)

    Energy Technology Data Exchange (ETDEWEB)

    Blanchat, T. [Sandia National Laboratories, Albuquerque, NM (United States); Malliakos, A. [U.S. Nuclear Regulatory Commission, Washington, DC (United States)

    1997-03-01

    Passive autocatalytic recombiners (PARs) have been under consideration in the U.S. as a combustible gas control system in advanced light water reactor (ALWR) containments for design basis and severe accidents. PARs do not require a source of power. Instead they use palladium or platinum as a catalyst to recombine hydrogen and oxygen gases into water vapor upon contact with the catalyst. Energy from the recombination of hydrogen with oxygen is released at a relatively slow but continuous rate into the containment which prevents the pressure from becoming too high. The heat produced creates strong buoyancy effects which increases the influx of the surrounding gases to the recombiner. These natural convective flow currents promote mixing of combustible gases in the containment. PARs are self-starting and self-feeding under a very wide range of conditions. The recombination rate of the PAR system needs to be great enough to keep the concentration of hydrogen (or oxygen) below acceptable limits. There are several catalytic recombiner concepts under development worldwide. The USNRC is evaluating a specific design of a PAR which is in an advanced stage of engineering development and has been proposed for ALWR designs. Sandia National laboratories (SNL), under the sponsorship and the direction of the USNRC, is conducting an experimental program to evaluate the performance of PARs. The PAR will be tested at the SURTSEY facility at SNL. The test plan currently includes the following experiments: experiments will be conducted to define the startup characteristics of PARs (i.e., to define what is the lowest hydrogen concentration that the PAR starts recombining the hydrogen with oxygen); experiments will be used to define the hydrogen depletion rate of PARs as a function of hydrogen concentration; and experiments will be used to define the PAR performance in the presence of high concentrations of steam. (author)

  13. 正激式开关电源传导电磁干扰研究%Study on Conducted EMI in Forward Switching Power

    Institute of Scientific and Technical Information of China (English)

    谢静; 陈少昌; 龙宏波

    2011-01-01

    With the development of switching power supply to the direction of high-frequency and integration,the study on its Electro-Magnetic Interference (EMI) has become increasingly important. A conducted EMI analysis model was established for forward switching power supply, and the main sources of interference and interference coupling paths were analyzed. The software Pspice was used to analyze the effect of circuit parameters on EMI. According to result of the analysis ,the methods of RP-offset and adding lossless network buffer were proposed to improve the conducted EMI of switching power. Simulation result verified the effectiveness of the method.%随着开关电源向高频化、集成化方向发展,其电磁干扰问题的研究显得越来越重要.本文以正激式开关电源为对象,建立了电源传导电磁干扰模型,分析了主要的干扰源和干扰耦合路径,使用PSpice软件仿真分析了电路参数对电磁干扰的影响.根据分析提出了反相抵消和加无损缓冲网络的方法,以改善电源的传导EMI,并进行了验证,证明了方法的有效性.

  14. Brochosomes produced by leafhoppers-a widely unknown, yet highly abundant species of bioaerosols in ambient air

    Science.gov (United States)

    Wittmaack, Klaus

    Brochosomes are excitingly shaped hollow spherical particles produced by leafhoppers (Cicadelliae), presumably to serve as a very efficient water-repellent protective surface coating. The spheroids have a diameter between 250 and 600 nm and are made of a network of protein-lipid rods, arranged in the form of hexagons and pentagons. Brochosomes in the atmosphere have been described only a few times and the reported concentrations were usually small. The cause of the apparently rare occurrence of these particles in ambient air is shown to be twofold. First, most of the brochosomes are airborne not as individual species, but in the form of rather large clusters containing up to 100,000 particles. Second, for high-efficiency collection of particles with aerodynamically complex morphology such as brochosomes (or agglomerates of carbon nanoparticles), size selective sampling with impactors turned out to be more efficient the higher the nozzle velocity. In a series of sampling campaigns brochosomes were found to be the most abundant bioaerosol particles in a semi-urban atmosphere during the warm season. Occasionally, brochosomes tended to react with other nanoparticle matter. As a result, the presumably freshly produced brochosomes became strongly distorted, rearranging in a variety of exotic forms, including perfect or distorted domes or even a spider web.

  15. New insights into broad spectrum communities of the Early Holocene Near East: The birds of Hallan Çemi

    Science.gov (United States)

    Zeder, Melinda A.; Spitzer, Megan D.

    2016-11-01

    The Early Holocene in Near East was a pivotal transitional period that witnessed dramatic changes in climate and environment, human settlement, major changes in subsistence strategies focusing on a broad range of different plant and animal resources, and a radical restructuring of social relations. The remarkable corpus of avifauna from the Early Holocene site of Hallan Çemi in southeastern Turkey sheds new light on key issues about this dynamic period that has been termed the "Broad Spectrum Revolution". The avifauna from this important site demonstrate how Hallan Çemi occupants took advantage of the site's strategic location at the junction of multiple environmental zones by extracting a diverse range of seasonally available resources from both near-by and more distant eco-zones to cobble together a stable subsistence economy capable of supporting this small community throughout the year. They give testimony to the impacts of resource utilization over time, especially on species unable to rebound from sustained human hunting. At the same time, they show how Hallan Çemi residents mitigated these impacts by replacing depleted resources with alternative, more resilient ones that could be more sustainably harvested. They open a window onto the growing investment in feasting and ritual activity that helped bind this community together. In so doing they provide a means of empirically evaluating the efficacy of contrasting explanatory frameworks for the Broad Spectrum Revolution that gave rise to the subsequent domestication of plant and animals in the Near East. Contrary to frameworks that cast these developments as responses to resource depression, lessons learned from the Hallan Çemi avifauna lend support to frameworks that emphasize the human capacity to strategically target, capitalize, and improve upon circumscribed resource rich environments in a way that permits more permanent occupation of these niches. And they underscore the degree to which social and

  16. Monikulttuurisuuden sopeuttaminen Espoon mielenterveysyhdistys EMY Ry:n toimintaan Elävä kirjasto -menetelmän avulla.

    OpenAIRE

    Punkka, Jonna Marita; Kärkkäinen, Antti

    2010-01-01

    Opinnäytetyön tarkoituksena on tuottaa tietoa monikulttuurisuudesta Espoon mielenterveysyhdistyksen kävijäkunnalle sekä sopeuttaa maahanmuuttajaryhmän perustamista yhdistyksen toimintaan. Työ on laadullinen tutkimus, jossa aineisto kerättiin Elävä kirjasto -menetelmän avulla. Tutkimusmenetelmänä käytettiin osallistuvaa havainnointia ja tulokset on analysoitu aineiston sisällönanalyysillä. Opinnäytetyö tehtiin yhteistyössä Espoon mielenterveysyhdistys EMY ry:n kanssa, joka on kolmannen sektori...

  17. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  18. A study of occurrence rates of Electromagnetic Interference (EMI) to aircraft with a focus on HIRF (external) High Intensity Radiated Fields

    Science.gov (United States)

    Shooman, Martin L.

    1994-01-01

    This report presents the methodology and results of a subjective study done by Polytechnic University to investigate Electromagnetic Interference (EMI) events on aircraft. The results cover various types of EMI from on-board aircraft systems, passenger carry-on devices, and externally generated disturbances. The focus of the study, however, was on externally generated EMI, termed High Intensity Radiated Fields (HIRF), from radars, radio and television transmitters, and other man-made emitters of electromagnetic energy. The study methodology used an anonymous questionnaire distributed to experts to gather the data. This method is known as the Delphi or Consensus Estimation technique. The questionnaire was sent to an expert population of 230 and there were 57 respondents. Details of the questionnaire, a few anecdotes, and the statistical results of the study are presented.

  19. Restraining of the EMI in Ignition Systems of UAV Engines%基于UAV发动机点火系统的EMI抑制研究

    Institute of Scientific and Technical Information of China (English)

    张学平; 濮思方; 张小林; 宋祖勋; 宁乐

    2012-01-01

    UAV集电子设备于一身,其最大射频电磁干扰(EMI)源自发动机点火系统,它不同程度地影响着机载计算机、自动驾驶仪等以及不同任务载荷的正常工作;通过对某UAV发动机研制的电容放电式点火系统(CDI)的电路和布局描述,研讨了屏蔽对其二次回路影响的机理,合理确定了工程路径.并研究出一种阻尼-屏蔽法实施在CDI中,降低点火系统EMI近20dB,同时不影响其可靠性;本研究的成功,使长期困扰CDI的EMI深入抑制取得了进步.%UAV systems bearing the complexities of integrated avionics are susceptible to the disturbance of electromagnetic interferences (EMI), that are typically originated from the ignition systems of UAV engines. The presence of EMI can deleteriously affect the functionality of the UAV computing units, auto piloting units, and various mission payloads etc. In this paper, by using the a novel electric design based on the capacitor-discharging ignition (CDI) circuits, we investigate the mechanism of the influence of electrical shielding on its second circuits, which facilitates the rational engineering designs. We focus on utilizing a damping-shielding-restraining methodology for the CDI, which greatly reduces the EMI of the ignition systems down to 20 dB with remaining the durability of the operation. Out results provide one strategy to efficiently restrain the undesirable EMI in the CDIs.

  20. Fabrication and EMI shielding effectiveness of Ag-decorated highly porous poly(vinyl alcohol)/Fe{sub 2}O{sub 3} nanofibrous composites

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hae-Rim [Department of Bioscience and Textile Technology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386-8567 (Japan); Kim, Byoung-Suhk, E-mail: kbsuhk@yahoo.com [Department of Organic Materials and Fiber Engineering, College of Engineering, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-756 (Korea, Republic of); Kim, Ick-Soo, E-mail: kim@shinshu-u.ac.jp [Department of Bioscience and Textile Technology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386-8567 (Japan); Nano Fusion Technology Research Group, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386-8567 (Japan)

    2012-08-15

    The Ag-decorated poly(vinyl alcohol) (PVA) composite nanofibrous webs incorporating Fe{sub 2}O{sub 3} nanoparticles were fabricated by electrospinning and metal-deposition methods for electromagnetic interference (EMI) shielding applications. The Ag-decorated PVA/Fe{sub 2}O{sub 3} composite nanofiber webs with various Ag thicknesses and different amounts of Fe{sub 2}O{sub 3} nanoparticles were prepared and used for EMI shielding measurement. For the EMI SE measurement, a near-field antenna measurement system was used. The measurement of EMI SE was carried out at the frequency range from 0.5 to 18 GHz, and the electromagnetic parameters were measured. The morphologies and microstructures of the resultant PVA/Fe{sub 2}O{sub 3} composite nanofiber webs were characterized using field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), respectively. The effects of surface morphologies and Fe{sub 2}O{sub 3} nanoparticles on the EMI shielding effectiveness of Ag-decorated PVA/Fe{sub 2}O{sub 3} composite nanofiber webs were investigated. -- Highlights: Black-Right-Pointing-Pointer We prepare Ag-decorated poly(vinyl alcohol) nanowebs incorporating Fe{sub 2}O{sub 3} nanoparticles. Black-Right-Pointing-Pointer Solvents will affect the fiber morphologies and Fe{sub 2}O{sub 3} nanoparticles dispersion. Black-Right-Pointing-Pointer EMI shielding effectiveness depends on the metal thickness and Fe{sub 2}O{sub 3} nanoparticles dispersion.

  1. Common-Mode EMI Reduction in Switching Flyback Power Supply by Implementing Cancellation Method of Heat-Sink Capacitor

    Directory of Open Access Journals (Sweden)

    Mohammad Rouholah Yazdani

    2015-01-01

    Full Text Available Electromagnetic compatibility in switching power converters which are noise sources themselves, has a special importance. Electromagnetic interference (EMI in the form of conducted or radiated reaches to sensitive sections and interferes with their operation. On the other, electromagnetic compatibility (EMC standards causes another forces to reduce noise in switching converters. Major part of noise is due to the common-mode (CM current passes through parasitic elements to the circuit ground (Earth. One of the important parasitic elements from the CM noise viewpoint is the switch heat-sink capacitor (common-mode capacitor. In this paper, a cancellation method of the heat-sink capacitor via a passive circuit is proposed in a 50W isolated flyback converter and is also modeled in OrCAD software. Also, experimental measurement results of the CM electromagnetic interference in regular and proposed flyback converter prototypes are presented to examine the modeling accuracy. Based on the experimental results, significant reduction of CM-EMI is verified after applying the cancellation method of the heat-sink capacitor.

  2. BioSense/SR-BioSpectra demonstrations of wide area/early warning for bioaerosol threats: program description and early test and evaluation results

    Science.gov (United States)

    Simard, Jean-Robert; Buteau, Sylvie; Lahaie, Pierre; Mathieu, Pierre; Roy, Gilles; Nadeau, Denis; McFee, John; Ho, Jim; Rowsell, Susan; Ho, Nicolas; Babin, François; Cantin, Daniel; Healey, Dave; Robinson, Jennifer; Wood, Scott; Hsu, Jack

    2011-11-01

    Threats associated with bioaerosol weapons have been around for several decades and have been mostly associated with terrorist activities or rogue nations. Up to the turn of the millennium, defence concepts against such menaces relied mainly on point or in-situ detection technologies. Over the last 10 years, significant efforts have been deployed by multiple countries to supplement the limited spatial coverage of a network of one or more point bio-detectors using lidar technology. The addition of such technology makes it possible to detect within seconds suspect aerosol clouds over area of several tens of square kilometers and track their trajectories. These additional capabilities are paramount in directing presumptive ID missions, mapping hazardous areas, establishing efficient counter-measures and supporting subsequent forensic investigations. In order to develop such capabilities, Defence Research and Development Canada (DRDC) and the Chemical, Biological, Radiological-Nuclear, and Explosives Research and Technology Initiative (CRTI) have supported two major demonstrations based on spectrally resolved Laser Induced Fluorescence (LIF) lidar: BioSense, aimed at defence military missions in wide open spaces, and SR-BioSpectra, aimed at surveillance of enclosed or semienclosed wide spaces common to defence and public security missions. This article first reviews briefly the modeling behind these demonstration concepts. Second, the lidar-adapted and the benchtop bioaerosol LIF chambers (BSL1), developed to challenge the constructed detection systems and to accelerate the population of the library of spectral LIF properties of bioaerosols and interferents of interest, will be described. Next, the most recent test and evaluation (T&E) results obtained with SR-BioSpectra and BioSense are reported. Finally, a brief discussion stating the way ahead for a complete defence suite is provided.

  3. Direct analysis of airborne mite allergen (Der f1) in the residential atmosphere by chemifluorescent immunoassay using bioaerosol sampler.

    Science.gov (United States)

    Miyajima, Kumiko; Suzuki, Yurika; Miki, Daisuke; Arai, Moeka; Arakawa, Takahiro; Shimomura, Hiroji; Shiba, Kiyoko; Mitsubayashi, Kohji

    2014-06-01

    Dermatophagoides farinae allergen (Der f1) is one of the most important indoor allergens associated with allergic diseases in humans. Mite allergen Der f1 is usually associated with particles of high molecular weight; thus, Der f1 is generally present in settled dust. However, a small quantity of Der f1 can be aerosolized and become an airborne component. Until now, a reliable method of detecting airborne Der f1 has not been developed. The aim of this study was to develop a fiber-optic chemifluorescent immunoassay for the detection of airborne Der f1. In this method, the Der f1 concentration measured on the basis of the intensity of fluorescence amplified by an enzymatic reaction between the labeled enzyme by a detection antibody and a fluorescent substrate. The measured Der f1 concentration was in the range from 0.49 to 250 ng/ml and a similar range was found by enzyme-linked immunosorbent assay (ELISA). This method was proved to be highly sensitive to Der f1 compared with other airborne allergens. For the implementation of airborne allergen measurement in a residential environment, a bioaerosol sampler was constructed. The airborne allergen generated by a nebulizer was conveyed to a newly sampler we developed for collecting airborne Der f1. The sampler was composed of polymethyl methacrylate (PMMA) cells for gas/liquid phases and some porous membranes which were sandwiched in between the two phases. Der f1 in air was collected by the sampler and measured using the fiber-optic immunoassay system. The concentration of Der f1 in aerosolized standards was in the range from 0.125 to 2.0 mg/m(3) and the collection rate of the device was approximately 0.2%.

  4. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  5. Baseline levels of bioaerosols and volatile organic compounds around a municipal waste incinerator prior to the construction of a mechanical-biological treatment plant.

    Science.gov (United States)

    Vilavert, Lolita; Nadal, Martí; Inza, Isabel; Figueras, María J; Domingo, José L

    2009-09-01

    New waste management programs are currently aimed at developing alternative treatment technologies such as mechanical-biological treatment (MBT) and composting plants. However, there is still a high uncertainty concerning the chemical and microbiological risks for human health, not only for workers of these facilities, but also for the population living in the neighborhood. A new MBT plant is planned to be constructed adjacently to a municipal solid waste incinerator (MSWI) in Tarragona (Catalonia, Spain). In order to evaluate its potential impact and to differentiate the impacts of MSWI from those of the MBT when the latter is operative, a pre-operational survey was initiated by determining the concentrations of 20 volatile organic compounds (VOCs) and bioaerosols (total bacteria, gram-negative bacteria, fungi and Aspergillus fumigatus) in airborne samples around the MSWI. The results indicated that the current concentrations of bioaerosols (ranges: 382-3882, 18-790, 44-926, and urban and industrial zones. With the exception of total bacteria, no correlations were observed between the environmental concentrations of biological agents and the direction/distance from the facility. However, total bacteria presented significantly higher levels downwind. Moreover, a non-significant increase of VOCs was detected in sites closer to the incinerator, which means that the MSWI could have a very minor impact on the surrounding environment. PMID:19346120

  6. Lightweight nanocomposites based on poly(vinylidene fluoride) and Al nanoparticles: Structural, thermal and mechanical characterization and EMI shielding capability

    Energy Technology Data Exchange (ETDEWEB)

    Arranz-Andrés, J., E-mail: jarranz@ictp.csic.es [Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid (Spain); Pulido-González, N. [Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid (Spain); Fonseca, C. [POLCA, Departamento de Química Industrial y Polímeros, E. T. de Ingenieros Industriales, Universidad Politécnica de Madrid, Ronda de Valencia, 3, 28012 Madrid (Spain); Pérez, E.; Cerrada, M.L. [Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid (Spain)

    2013-11-01

    Novel (nano)composites based on PVDF and different content of Al nanoparticles have been prepared in order to learn about their electromagnetic interference shielding capability. Very promising results are obtained, with an excellent balance between shielding and sample weight, so that these materials are potentially good alternatives to replace neat metals for that application. Moreover, a complete structural and morphological characterization, as well as an evaluation of their thermal and mechanical behavior, has been also performed. - Graphical abstract: EMI shielding capability in lightweight nanocomposites based on poly(vinylidene fluoride) and Al nanoparticles. - Highlights: • Novel hybrids based on PVDF and different contents of Al nanoparticles have been prepared. • A complete characterization of the nanocomposites has been performed. • Interactions between PVDF matrix and Al nanoparticles are deduced from FTIR. • Attenuation of the electromagnetic radiation increases spectacularly with the Al content.

  7. Explore on EMI Shielding and Hading Curtain%防辐射、遮光窗帘的研发

    Institute of Scientific and Technical Information of China (English)

    陈兰

    2014-01-01

    The aim of the development is focus on providing EMI and antistatic curtain,which has effective shading and better decorative.In this article,it has been described inthe choice of raw material,design,structure of fabric and ect.,and also some exmples have been explained.%防辐射、遮光窗帘的研发的目的是提供一种遮光性和装饰性更好的高档防电磁辐射防静电窗帘。本文从原材料选择、工艺设计、组织结构等几方面着手叙述,同时举例说明。

  8. A comparative study of EMI shielding properties of carbon nanofiber and multi-walled carbon nanotube filled polymer composites.

    Science.gov (United States)

    Yang, Yonglai; Gupta, Mool C; Dudley, Kenneth L; Lawrence, Roland W

    2005-06-01

    Electromagnetic interference shielding properties of carbon nanofiber- and multi-walled carbon nanotube-filled polystyrene composites were investigated in the frequency range of 8.2-12.4 GHz (X-band). It was observed that the shielding effectiveness of composites was frequency independent, and increased with the increase of carbon nanofiber or nanotube loading. At the same filler loading, multi-walled carbon nanotube-filled polystyrene composites exhibited higher shielding effectiveness compared to those filled with carbon nanofibers. In particular, carbon nanotubes were more effective than nanofibers in providing high EMI shielding at low filler loadings. The experimental data showed that the shielding effectiveness of the composite containing 7 wt% carbon nanotubes could reach more than 26 dB, implying that such a composite can be used as a potential electromagnetic interference shielding material. The dominant shielding mechanism of carbon nanotube-filled polystyrene composites was also discussed. PMID:16060155

  9. Finite element modelling of non-bonded piezo sensors for biomedical health monitoring of bones based on EMI technique

    Science.gov (United States)

    Srivastava, Shashank; Bhalla, Suresh; Madan, Alok; Gupta, Ashok

    2016-04-01

    Extensive research is currently underway across the world for employing piezo sensors for biomedical health monitoring in view of their obvious advantages such as low cost,fast dynamics response and bio-compatibility.However,one of the limitations of the piezo sensor in bonded mode based on the electro-mechanical impedance (EMI) technique is that it can cause harmful effects to the humans in terms of irritation ,bone and skin disease. This paper which is in continuation of the recent demonstration of non-bonded configuration is a step towards simulating and analyzing the non-bonded configuration of the piezo sensor for gauging its effectiveness using FEA software. It has been noted that the conductance signatures obtained in non-bonded mode are significantly close to the conventional bonded configuration, thus giving a positive indication of its field use.

  10. Introducing Software-Based Fault Handling Mechanism to Cope with Electromagnetic Interference (EMI in Digital Electronic Circuits

    Directory of Open Access Journals (Sweden)

    Jinadu Olayinka

    2012-08-01

    Full Text Available Digital circuits operating under radiation are subject to different kinds of permanent and transient effects. Most electromagnetic (EM environment in which electronic systems have to operate is becoming increasingly hostile while dependence on electronics is widespread and increasing. The need for digital architectures to survive faults and remain dependable despite the multiple-fault injection nature of the electromagnetic interference (EMI in microprocessors calls for the introduction of a software-based fault handling mechanism.Redundancy, which is a common answer to increasing error-coverage in most safety-critical applications offers higher dependability but for most low-cost computer based systems (including Digital Signal Processors, another technique is implemented for effectiveness. This paper implements the duplicate j-instruction rule on high-level programming to detect faulty  jumps. Code redundancy and consistency checks covers the fault to increase system reliability

  11. Field detection and identification of a bioaerosol suite by pyrolysis-gas chromatography-ion mobility spectrometry

    Science.gov (United States)

    Snyder, A. Peter; Tripathi, Ashish; Maswadeh, Waleed M.; Ho, Jim; Spence, Mel

    2002-06-01

    Improvements were made to a pyrolysis-gas chromatography-ion mobility spectrometry stand-alone biodetector to provide more pyrolyzate compound information to the IMS detector module. Air carrier gas flowing continuously through the pyrolysis tube, the rate of air flow, and pyrolysis rate were found to improve the relative quality and quantity of pyrolyzate compounds detected by the IMS detector compare to earlier work. These improvements allowed a greater degree of confidence in the correlation of biological aerosols obtain in outdoor testing scenarios to a standard GC-IMS biological aerosol dataset. The airflow improvement allowed more biomarker compounds to be observed in the GC-IMS data domain for aerosols of Gram-negative Erwinia herbicola (EH) and ovalbumin protein as compared to previous studies. Minimal differences were observed for Gram-positive spores of Bacillus subtilis var. globigii (BG) from that of earlier work. Prior outdoor aerosol challenges dealt with the detection of one organism, either EH or BG. Biological aerosols were disseminated in a Western Canadian prairie and the Py-GC-IMS was tested for its ability to detect the biological aerosols. The current series of outdoor trials consisted of three different biological aerosol challenges. Forty-two trials were conducted and a simple area calculation of the GC-IMS data domain biomarker peaks correlated with the correct bioaerosol challenge in 30 trials. In another 7 trials, the status of an aerosol was determined to be biological in origin. Two additional trials had no discernible, unambiguous GC-IMS biological response, because they were black water sprays. Reproducible limits of detection were at a concentration of less than 0.5 bacterial analyte-containing particles per liter of air (ACPLA). In order to realize this low concentration, an aerosol concentrator was used to concentrate 2000 liters of air in 2.2 minutes. Previous outdoor aerosol trials have shown the Py-GC-IMS device to be a credible

  12. Occupational hygiene in terms of volatile organic compounds (VOCs) and bioaerosols at two solid waste management plants in Finland

    International Nuclear Information System (INIS)

    Highlights: ► Odorous VOCs: acetic acid, 2,3-butanedione, ethyl acetate, alpha-pinene and limonene. ► VOC concentrations did not exceed occupational exposure limit concentrations. ► 2,3-Butanedione as the health effecting compound is discussed. ► Endotoxin concentrations may cause health problems in waste treatment. - Abstract: Factors affecting occupational hygiene were measured at the solid waste transferring plant at Hyvinkää and at the optic separation plant in Hämeenlinna. Measurements consisted of volatile organic compounds (VOCs) and bioaerosols including microbes, dust and endotoxins. The most abundant compounds in both of the plants were aliphatic and aromatic hydrocarbons, esters of carboxylic acids, ketones and terpenes. In terms of odour generation, the most important emissions were acetic acid, 2,3-butanedione, ethyl acetate, alpha-pinene and limonene due to their low threshold odour concentrations. At the optic waste separation plant, limonene occurred at the highest concentration of all single compounds of identified VOCs. The concentration of any single volatile organic compound did not exceed the occupational exposure limit (OEL) concentration. However, 2,3-butanedione as a health risk compound is discussed based on recent scientific findings linking it to lung disease. Microbe and dust concentrations were low at the waste transferring plant. Only endotoxin concentrations may cause health problems; the average concentration inside the plant was 425 EU/m3 which clearly exceeded the threshold value of 90 EU/m3. In the wheel loader cabin the endotoxin concentrations were below 1 EU/m3. High microbial and endotoxin concentrations were measured in the processing hall at the optic waste separation plant. The average concentration of endotoxins was found to be 10,980 EU/m3, a concentration which may cause health risks. Concentrations of viable fungi were quite high in few measurements in the control room. The most problematic factor was

  13. The Expression of the Thrombin Receptors PAR-3 and PAR-4 is Downregulated in Pancreatic Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Claudia Rudroff

    2015-05-01

    Full Text Available Background: Patients with pancreatic cancer frequently suffer from thrombosis as a consequence of excess thrombin generation. In addition to its role in the plasmatic coagulation cascade, thrombin induces numerous cellular effects by activating a unique group of G-protein-coupled receptors on the cell membrane, the proteinase-activated receptors (PARs. At present, PAR-1, PAR-3 and PAR-4 are known to be activated by thrombin. We previously demonstrated a putative role for PAR-1 in pancreatic cancer progression, but little is known about the physiological and pathophysiological roles of PAR-3 and PAR-4. In the present study, we examined the expression patterns of PAR-3 and PAR-4 in pancreatic tissue and pancreatic cancer cells. Methods: Tissue samples from three patients with pancreatic adenocarcinoma and six human pancreatic carcinoma cell lines were examined. Gene expression was analysed by RT-PCR and quantified by HPLC. Protein expression was determined by Western blot analysis. Data analysis was performed using ANOVA in SPSS. Results and Conclusion: In contrast to PAR-1, both PAR-3 and PAR-4 were expressed in healthy pancreases but downregulated in pancreatic cancer. The contrasting expression patterns of PAR-3 and PAR-4 compared with PAR-1 indicate that the mechanism that regulates the cellular effects of thrombin on tumor progression remains to be fully elucidated.

  14. Traitement des eaux par électrofloculation

    OpenAIRE

    Cansado, Isabel

    1997-01-01

    Traitement des eaux par electrofloculation Les écosystèmes aquatiques sont très affectés par les eaux de rejet qui sont déversées dans les cours d’eau. La charge de ces eaux existe sous diverses formes: solutés, colloïdes ou particules. Il est important de traiter l’eau usée à de faibles coûts au lieu de la rejeter directement dans le milieu récepeteur. Dans le but d’améliorer les procédés physico-chimiques de déstabilisation des émulsions, nous étudions les traitements par électrocoagulat...

  15. Programmation par contraintes avec des fourmis

    OpenAIRE

    Khichane, Madjid; Albert, Patrick; Solnon, Christine

    2008-01-01

    National audience On explore dans cet article les possibilités d'intégration de la métaheuristique d'optimisation par colonies de fourmis (ACO) dans un langage de programmation par contraintes (PPC). L'idée est d'utiliser un langage de PPC pour décrire le problème à résoudre, ainsi que pour propager et vérifier les contraintes, et d'utiliser ACO pour guider la recherche de solutions. On illustre notre approche sur le problème d'ordonnancement de voitures.

  16. Task 4 - EMI/RFI Issues Potentially Impacting Electromagnetic Compatibility of I&C Systems (NRCHQ6014D0015)

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Richard Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ewing, Paul D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-05-01

    The U.S. Nuclear Regulatory Commission’s (NRC’s) regulations in Part 50, “Domestic Licensing of Production and Utilization Facilities,” of Title 10 of the Code of Federal Regulations (10 CFR Part 50) state that structures, systems, and components important to safety in a nuclear power plant are to be designed to accommodate the effects of environmental conditions (i.e., remain functional under all postulated service conditions) and that design control measures such as testing are to be used to check the adequacy of design. Regulatory Guide (RG) 1.180 was developed to provide guidance to licensees and applicants on methods acceptable to the NRC staff for complying with the NRC’s regulations on design, installation, and testing practices for addressing the effects of electromagnetic and radio-frequency interference (EMI/RFI) and power surges on safety-related instrumentation and control (I&C) systems. The first revision of RG 1.180 was issued in January 2000 and a second revision was issued in October 2003*. The second revision differed from the first revision in endorsing Military Standard (MIL-STD)-461E and the International Electrotechnical Commission (IEC) Standard (Std) 61000 series of EMI/RFI test methods, extending the guidance to cover signal line testing, incorporating frequency ranges where portable communications devices are experiencing increasing use, and relaxing the operating envelopes (test levels) when experience and confirmatory research warranted. It also offered exemptions from specific test criteria based on technical considerations such as plant conditions and the intended location of the safety-related I&C equipment. Since the last revision, new requirements have been identified, associated RGs have been created and updated, and additional industry guidance has been developed. Additionally, the operational environment has changed with the increase in wireless communication technology for both personal (smartphone) and industrial

  17. SWANN ORGANIQUE (EN PASSANT PAR BECKETT PANOPTIQUE

    Directory of Open Access Journals (Sweden)

    Sjef Houppermans

    2013-12-01

    Full Text Available Comme quoi Swann a bel et bien un corps souffrant et jouissant. Comme quoi Swann absorbe le monde surtout par ses six sens. Comme quoi l´univers de Swann est une aire de dissémination que Samuel Beckett sonde exemplairement dans son étude de 1930.

  18. Baseline levels of bioaerosols and volatile organic compounds around a municipal waste incinerator prior to the construction of a mechanical-biological treatment plant

    International Nuclear Information System (INIS)

    New waste management programs are currently aimed at developing alternative treatment technologies such as mechanical-biological treatment (MBT) and composting plants. However, there is still a high uncertainty concerning the chemical and microbiological risks for human health, not only for workers of these facilities, but also for the population living in the neighborhood. A new MBT plant is planned to be constructed adjacently to a municipal solid waste incinerator (MSWI) in Tarragona (Catalonia, Spain). In order to evaluate its potential impact and to differentiate the impacts of MSWI from those of the MBT when the latter is operative, a pre-operational survey was initiated by determining the concentrations of 20 volatile organic compounds (VOCs) and bioaerosols (total bacteria, Gram-negative bacteria, fungi and Aspergillus fumigatus) in airborne samples around the MSWI. The results indicated that the current concentrations of bioaerosols (ranges: 382-3882, 18-790, 44-926, and 3 for fungi at 25 deg. C, fungi at 37 deg. C, total bacteria, and Gram-negative bacteria, respectively) and VOCs (ranging from 0.9 to 121.2 μg/m3) are very low in comparison to reported levels in indoor and outdoor air in composting and MBT plants, as well in urban and industrial zones. With the exception of total bacteria, no correlations were observed between the environmental concentrations of biological agents and the direction/distance from the facility. However, total bacteria presented significantly higher levels downwind. Moreover, a non-significant increase of VOCs was detected in sites closer to the incinerator, which means that the MSWI could have a very minor impact on the surrounding environment.

  19. Comparison of EMI/RFI requirements to qualify the equipment for nuclear power plant. (RG 1.180, EPRI TR 102323, IEC 62003 and GB/T 11684)

    International Nuclear Information System (INIS)

    One issue that has been problematic for new plant equipment and especially for digital instrumentation and control (I and C) systems in recent years is electromagnetic compatibility (EMC). In some reports for nuclear power plant (NPP), electromagnetic interference (EMI), radio frequency interference (RFI), and power surges have been identified as environmental conditions that can affect the performance of safety-related electrical equipment. There are mainly two reference guides for applying to qualify EMI/RFI requirements of the equipment used in a NPP: US NRC RG 1.180 and EPRI TR 102323. Recently, IEC published the standard for the equipment in the NPP, IEC 62003. This paper has compared the requirements of these, including comparing of the requirement of the Chinese national standard, GB/T 11684

  20. 固态高频组件的电磁干扰与电磁兼容%EMI and EMC of Solid State RF Module

    Institute of Scientific and Technical Information of China (English)

    周燕; 黄江

    2001-01-01

    This paper introduces the configuration of RF module (including transmitter module and T/R module ) used in phased array radar and EMI within module. Shielding effectiveness of an enclosure in usually used frequency band is analyzed. EMC design techniques of RF module in engineering applications are also presented.%本文介绍了用于相控阵雷达的射频功率组件(包括发射组件和T/R组件)的组成及电磁干扰(EMI)问题,对各频段的射频功率组件机壳的屏蔽效能进行了分析和计算,给出了工程应用中高频组件的电磁兼容(EMC)设计方法。

  1. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    International Nuclear Information System (INIS)

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  2. A combined global and local approach to elucidate spatial organization of the Mycobacterial ParB-parS partition assembly.

    Science.gov (United States)

    Chaudhuri, Barnali N; Gupta, Sayan; Urban, Volker S; Chance, Mark R; D'Mello, Rhijuta; Smith, Lauren; Lyons, Kelly; Gee, Jessica

    2011-03-22

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  3. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition Assembly

    Energy Technology Data Exchange (ETDEWEB)

    B Chaudhuri; S Gupta; V Urban; M Chance; R DMello; L Smith; K Lyons; J Gee

    2011-12-31

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  4. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhuri, Barnali [University of Buffalo, The State University of New York; Gupta, Sayan [Case Western Reserve University; Urban, Volker S [ORNL; Chance, Mark [Case Western Reserve University; D' Mello, Rhijuta [Case Western Reserve University; Smith, Lauren [University of Buffalo, The State University of New York; Lyons, Kelly [University of Buffalo, The State University of New York; Gee, Jessica [University of Buffalo, The State University of New York

    2010-01-01

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  5. EMI performance comparison of two-level and three-level inverters in small dc-link capacitors based motor drives

    DEFF Research Database (Denmark)

    Maheshwari, Ram Krishan; Munk-Nielsen, Stig; Busquets-Monge, S.

    2012-01-01

    The size of passive components in an adjustable speed drive can be reduced by using small dc-link capacitors. The EMI filter in the drive also consists of passive components. The size of the filter can be reduced by using a three-level inverter, which can have low output voltage distortion. Howev....... Results show that the conducted emission from the three-level inverter is lower than that of the two-level inverter. Thus, a three-level inverter requires a smaller EMI filter in motor drives with small dc-link capacitors.......The size of passive components in an adjustable speed drive can be reduced by using small dc-link capacitors. The EMI filter in the drive also consists of passive components. The size of the filter can be reduced by using a three-level inverter, which can have low output voltage distortion. However......, the shaft voltage, and the conducted emission for the small dc-link capacitor based three-level inverter are compared with that of the two-level inverter operated with space vector PWM strategy. Experimental results for the common mode voltage, the shaft voltage, and the conducted emission are presented...

  6. Un successeur de Bouguer : \\'Etienne B\\'ezout (1730 ? 1783) commissaire pour la marine \\`a l'Acad\\'emie royale des sciences

    CERN Document Server

    Alfonsi, Liliane

    2009-01-01

    \\'Etienne B\\'ezout, member of the Acad\\'emie Royale des Sciences, have to study some works and books sended at the Acad\\'emy. In this article, we will look at this responsibility for Navy, before and after 1764, which is the year of B\\'ezout's nomination at the charge of Examinateur des Gardes du Pavillon et de la Marine. Each year he must go to Brest, Rochefort and Toulon harbours to examine the Gardes de la Marine. This give to him titles and qualifications as expert in sailing. We will see his participation at an Academy polemic : Blondeau versus Bouguer/Lacaille on a navigation book. Almost in the same time, \\'Etienne B\\'ezout will be member of the Acad\\'emie de Marine de Brest in 1769. We will see his work in this last Academy. At last, we will study his Trait\\'e de navigation, written in 1769 and we will compare to Bouguer's Navigation book.

  7. Assessment of risks of EMI for personal medical electronic devices (PMEDs) from emissions of millimeter-wave security screening systems

    Science.gov (United States)

    Witters, Donald; Bassen, Howard; Guag, Joshua; Addissie, Bisrat; LaSorte, Nickolas; Rafai, Hazem

    2013-06-01

    This paper describes research and testing of a representative group of high priority body worn and implantable personal medical electronic devices (PMEDs) for exposure to millimeter wave (MMW) advanced imaging technology (AIT) security systems used at airports. The sample PMEDs included in this study were implantable cardiac pacemakers, ICDs, neurostimulators and insulin pumps. These PMEDs are designed and tested for susceptibility to electromagnetic interference (EMI) under the present standards for medical device electromagnetic compatibility (EMC). However, the present standards for medical equipment do not address exposure to the much higher frequency fields that are emitted by MMW security systems. Initial AIT emissions measurements were performed to assess the PMED and passenger exposures. Testing protocols were developed and testing methods were tailored to the type of PMED. In addition, a novel exposure simulation system was developed to allow controlled EMC testing without the need of the MMW AIT system. Methodology, test results, and analysis are presented, along with an assessment of the human exposure and risks for PMED users. The results on this study reveal no effects on the medical devices from the exposure to the MMW security system. Furthermore, the human exposure measurements and analysis showed levels well below applicable standard, and the risks for PMED users and others we assessed to be very low. These findings apply to the types of PMEDs used in the study though these findings might suggest that the risks for other, similar PMEDs would likely be similar.

  8. Preparation of flower-like CuS by solvothermal method for photocatalytic, UV protection and EMI shielding applications

    Science.gov (United States)

    Hu, Xiao-Sai; Shen, Yong; Xu, Li-Hui; Wang, Li-Ming; Lu, Li-sha; Zhang, Ya-ting

    2016-11-01

    The flower-like CuS hierarchical structures were synthesized by solvothermal method. The as-prepared products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared(FTIR) spectroscopy, UV-vis optical absorption spectroscopy and thermogravimetric analysis (TGA). The results demonstrated that the as-prepared flower-like CuS with the diameter of 1-5 um was pure hexagonal phase CuS and had well-defined flower-like structures. (1) The as-prepared CuS was proved to possess high photocatalytic performance with band gap of 1.45 eV. The degradation rate of Methylene blue (MB) was up to, 98.26%, 100% after 30 min under UV and visible irradiation. (2)The UPF of cotton fabric treated with CuS reached up to 174 compared with the original untreated fabric with the UPF 20.62. (3) The electromagnetic interference shielding effectiveness (EMI SE) of CuS coating was up to 27-31 dB when the content of CuS increased to 28.6%wt in the frequency of 300 KHz-3 GHz. Furthermore, the influence of reaction conditions on the morphology of the as-prepared CuS was investigated systematically and the possible formation mechanism of the CuS hierarchical structure was also proposed.

  9. Properties of jet engine combustion particles during the PartEmis experiment. Hygroscopic growth at supersaturated conditions

    Science.gov (United States)

    Hitzenberger, R.; Giebl, H.; Petzold, A.; Gysel, M.; Nyeki, S.; Weingartner, E.; Baltensperger, U.; Wilson, C. W.

    2003-07-01

    During the EU Project PartEmis, the microphysical properties of aircraft combustion aerosol were investigated. This study is focused on the ability of exhaust aerosols to act as cloud condensation nuclei (CCN). The combustor was operated at two different conditions representing old and modern aircraft engine technology. CCN concentrations were measured with the University of Vienna CCN counter [ Giebl et al., 2002] at supersaturations around 0.7%. The activation ratio (fraction of CCN in total aerosol) depended on the fuel sulphur content (FSC) and also on the operation conditions. CCN/CN ratios increased from 0.93 through 1.43 to 5.15 . 10-3 (old cruise conditions) and 0.67 through 3.04 to 7.94 . 10-3 (modern cruise conditions) when FSC increased from 50 through 410 to1270 μg/g. The activation behaviour was modelled using classical theories and with a semi-empirical model [ Gysel et al., 2003] based on measured hygroscopicity of the aerosol under subsaturated conditions, which gave the best agreement.

  10. Metody snižování emisí oxidu uhličitého

    OpenAIRE

    Mališ, Jan

    2009-01-01

    Diplomová práce je zaměřená na problematiku tvorby emisí CO2 v důsledku spalování fosilních paliv a posouzení způsobů, jimiž lze tvorbu CO2 při spalovacích procesech snížit, resp. CO2 z produktů spalování odstranit. Na základě řady literárních zdrojů byla provedena rekapitulace spotřeby primárních energetických zdrojů ve světě za období 1971 až 2006. Jelikož spalování fosilních paliv je spojeno ve všech případech s produkcí oxidu uhličitého, byl demonstrován výpočet měrné tvorby CO2 při spalo...

  11. Effect of helium gas pressure on dc conduction mechanism and EMI shielding properties of nanocrystalline carbon thin films

    International Nuclear Information System (INIS)

    This paper reports the effect of helium partial pressures ∼1.2 × 10−5 (base pressure), 1.4 × 10−4, 8.6 × 10−3 and 0.1 mbar on the variable range hopping conduction in nanocrystalline carbon thin films deposited by filtered cathodic jet carbon arc technique. High resolution transmission electron microscopy studies suggest the random distribution of nanocrystallites (∼3–7 nm) in the amorphous matrix. The DC conduction behavior of the deposited nanocrystalline films has been studied in the light of Mott's variable range hopping (VRH) model and found to obey three dimensional VRH conduction. The randomly distributed nanocrystallites in amorphous matrix may lead to change in the distribution of density of states near Fermi level and hence, the conduction behavior. The enhanced electrical conductivity of the deposited films due to the helium environment makes them suitable for electromagnetic interference shielding applications. The sample deposited at a helium partial pressure of 0.1 mbar has a value of shielding effectiveness ∼7.84 dB at 18 GHz frequency. - Highlights: • Nanocrystalline carbon thin films (NCTF) has been deposited by FCJCA technique. • Effect of helium gas pressure has been studied on the properties of NCTF. • Investigation of EMI shielding properties of NCTF has been carried out

  12. Effect of helium gas pressure on dc conduction mechanism and EMI shielding properties of nanocrystalline carbon thin films

    Energy Technology Data Exchange (ETDEWEB)

    Rawal, Ishpal, E-mail: rawalishpal@gmail.com [Department of Physics, Kirori Mal College, University of Delhi, Delhi 110007 (India); Panwar, O.S., E-mail: ospanwar@mail.nplindia.ernet.in [Polymorphic Carbon Thin Films Group, Physics of Energy Harvesting Division, CSIR-National Physical Laboratory, Dr. K. S. Krishnan Road, New Delhi 110012 (India); Tripathi, R.K. [Polymorphic Carbon Thin Films Group, Physics of Energy Harvesting Division, CSIR-National Physical Laboratory, Dr. K. S. Krishnan Road, New Delhi 110012 (India); Singh, Avanish Pratap; Dhawan, S.K. [Polymeric and Soft Materials Group, Physics Engineering of Carbon, CSIR-National Physical Laboratory, Dr. K. S. Krishnan Road, New Delhi 110012 (India); Srivastava, A.K. [Electron and Ion Microscopy, Sophisticated and Analytical Instruments, CSIR-National Physical Laboratory, Dr. K. S. Krishnan Road, New Delhi 110012 (India)

    2015-05-05

    This paper reports the effect of helium partial pressures ∼1.2 × 10{sup −5} (base pressure), 1.4 × 10{sup −4}, 8.6 × 10{sup −3} and 0.1 mbar on the variable range hopping conduction in nanocrystalline carbon thin films deposited by filtered cathodic jet carbon arc technique. High resolution transmission electron microscopy studies suggest the random distribution of nanocrystallites (∼3–7 nm) in the amorphous matrix. The DC conduction behavior of the deposited nanocrystalline films has been studied in the light of Mott's variable range hopping (VRH) model and found to obey three dimensional VRH conduction. The randomly distributed nanocrystallites in amorphous matrix may lead to change in the distribution of density of states near Fermi level and hence, the conduction behavior. The enhanced electrical conductivity of the deposited films due to the helium environment makes them suitable for electromagnetic interference shielding applications. The sample deposited at a helium partial pressure of 0.1 mbar has a value of shielding effectiveness ∼7.84 dB at 18 GHz frequency. - Highlights: • Nanocrystalline carbon thin films (NCTF) has been deposited by FCJCA technique. • Effect of helium gas pressure has been studied on the properties of NCTF. • Investigation of EMI shielding properties of NCTF has been carried out.

  13. Mercury exposure associated with altered plasma thyroid hormones in the declining western pond turtle (Emys marmorata) from California mountain streams

    Science.gov (United States)

    Meyer, Erik; Eagles-Smith, Collin A.; Sparling, Donald; Blumenshine, Steve

    2014-01-01

    Mercury (Hg) is a global threat to wildlife health that can impair many physiological processes. Mercury has well-documented endocrine activity; however, little work on the effects of Hg on the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in aquatic wildlife exists despite the fact that it is a sensitive endpoint of contaminant exposure. An emerging body of evidence points to the toxicological susceptibility of aquatic reptiles to Hg exposure. We examined the endocrine disrupting potential of Hg in the western pond turtle (Emys marmorata), a long-lived reptile that is in decline throughout California and the Pacific Northwest. We measured total Hg (THg) concentrations in red blood cells (RBCs) and plasma T3 and T4 of turtles from several locations in California that have been impacted by historic gold mining. Across all turtles from all sites, the geometric mean and standard error THg concentration was 0.805 ± 0.025 μg/g dry weight. Sampling region and mass were the strongest determinants of RBC THg. Relationships between RBC THg and T3 and T4 were consistent with Hg-induced disruption of T4 deiodination, a mechanism of toxicity that may cause excess T4 levels and depressed concentrations of biologically active T3.

  14. The extra-large light-gas gun of the Fraunhofer EMI: Applications for impact cratering research

    Science.gov (United States)

    Lexow, B.; Wickert, M.; Thoma, K.; SchńFer, F.; Poelchau, M. H.; Kenkmann, T.

    2013-01-01

    The extra-large light-gas gun (XLLGG) at the Fraunhofer Ernst-Mach-Institut (EMI, Efringen-Kirchen, Germany) is a two-stage light-gas gun that can accelerate projectile masses of up to 100 g up to velocities of 6 km s-1. The accelerator's set-up allows various combinations of pump and launch tubes for applications in different fields of hypervelocity impact research. In the framework of the MEMIN (Multidisciplinary Experimental and Modeling Impact Research Network) program, the XLLGG is used for mesoscale cratering experiments with projectiles made of steel and of iron meteorites, and targets consisting of sandstone and other rocks. The craters produced with this equipment reach a diameter of up to 40 cm, a size unique in laboratory cratering research. With the implementation of neural networks, the acceleration process is being optimized, currently yielding peak velocities of 7.8 km s-1 for a 100 g projectile. Here, we summarize technical aspects of the XLLGG.

  15. Regional inhibition of cholinesterase in free-ranging western pond turtles (Emys marmorata) occupying California mountain streams.

    Science.gov (United States)

    Meyer, Erik; Sparling, Donald; Blumenshine, Steve

    2013-03-01

    The present study investigated the potential effects of cholinesterase (ChE)-inhibiting pesticides on western pond turtles (Emys marmorata) occupying streams in two regions of California, USA. The southern region was suspected of having increased exposure to atmospheric deposition of contaminants originating from Central Valley agriculture. The northern region represented reference ChE activities because this area was located outside of the prominent wind patterns that deposit pesticides into the southern region. Total ChE activity was measured in plasma from a total of 81 turtles from both regions. Cholinesterase activity of turtles was significantly depressed by 31% (p = 0.005) in the southern region after accounting for additional sources of variation in ChE activity. Male turtles had significantly increased ChE activity compared with females (p = 0.054). Cloaca temperature, length, mass, handling time, body condition, and lymph presence were not significant predictors of turtle ChE activity. In the southern region, 6.3% of the turtles were below the diagnostic threshold of two standard deviations less than the reference site mean ChE activity. Another diagnostic threshold determined that 75% of the turtles from the southern region had ChE activities depressed by 20% of the reference mean. The decrease in ChE activity in the southern region suggests sublethal effects of pesticide exposure, potentially altering neurotransmission, which can result in various deleterious behaviors. PMID:23341143

  16. Technology-based management of environmental organizations using an Environmental Management Information System (EMIS): Design and development

    Science.gov (United States)

    Kouziokas, Georgios N.

    2016-01-01

    The adoption of Information and Communication Technologies (ICT) in environmental management has become a significant demand nowadays with the rapid growth of environmental information. This paper presents a prototype Environmental Management Information System (EMIS) that was developed to provide a systematic way of managing environmental data and human resources of an environmental organization. The system was designed using programming languages, a Database Management System (DBMS) and other technologies and programming tools and combines information from the relational database in order to achieve the principal goals of the environmental organization. The developed application can be used to store and elaborate information regarding: human resources data, environmental projects, observations, reports, data about the protected species, environmental measurements of pollutant factors or other kinds of analytical measurements and also the financial data of the organization. Furthermore, the system supports the visualization of spatial data structures by using geographic information systems (GIS) and web mapping technologies. This paper describes this prototype software application, its structure, its functions and how this system can be utilized to facilitate technology-based environmental management and decision-making process.

  17. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  18. Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells

    DEFF Research Database (Denmark)

    Albrektsen, T; Sørensen, B B; Hjortø, G M;

    2007-01-01

    Out of 8500 genes, FVIIa stimulation induced differential regulation of 39 genes most of which were not previously recognized as FVIIa regulated. All genes regulated by FVIIa were similarly regulated by a PAR2 agonist peptide confirming FVIIa signaling via PAR2. An appreciable fraction of the PAR...

  19. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were pr...

  20. Combined DSEK and Transconjunctival Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Mona Sane

    2016-01-01

    Full Text Available We report here three patients who underwent combined Descemet’s stripping with endothelial keratoplasty and transconjunctival pars plana vitrectomy for bullous keratopathy and posterior segment pathology. A surgical technique and case histories are described. Anatomic and visual outcomes of combined Descemet’s stripping with endothelial keratoplasty and vitrectomy were excellent. Our experience provides technical guidelines and limitations. The combined minimally invasive techniques allow for rapid anatomical recovery and return of function and visual acuity in a single sitting.

  1. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas;

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  2. Recombination in the Human Pseudoautosomal Region PAR1

    OpenAIRE

    Anjali G Hinch; Nicolas Altemose; Nudrat Noor; Peter Donnelly; Simon R Myers

    2014-01-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this o...

  3. Modeling and Analysis of Digital Active EMl Filter with Time Delay%数字有源 EMI 滤波系统延迟的建模与分析

    Institute of Scientific and Technical Information of China (English)

    姬军鹏; 胡雪利; 陈文洁; 曾光; 华志广

    2015-01-01

    With the development of the digital processing technology,and the sharp increasing of the speed and accuracy of data acquisition,the DAEF technology becomes a new direction of the EMI filter technology.As the frequency of EMI signal is high,the delay time of system has great impact on system performance and cannot be ignored,which needs more study.In this pa-per,the reason of the delay time existence was analyzed in the DAEF system,and with consideration of delay time the model of DAEF system was built.The impact of the delay time on the EMI filter performance was analyzed by simulation.The DAEF control system platform was built based on FPGA.The correctness of the DAEF model with delay character was verified.The influence rule of delay time on the filter performance of DAEF system was revealed.The results help to further study and widespread application of digital active EMI filter.%随着数字处理技术的进步,数据采集速度与精度的大幅提高,使得数字有源电磁干扰滤波技术 DAEF (Digital Active EMI Filter)成为 EMI(Electro-Magnetic Interference)滤波技术发展的新方向。由于 EMI 信号频率较高,所以EMI 滤波控制中的延迟对滤波性能的影响不可忽视,需要深入研究。本文详细分析了数字有源 EMI 滤波系统中产生延迟的原因,建立了具有延迟特性的数字有源 EMI 滤波系统模型,仿真分析了延迟时间对 EMI 滤波系统滤波性能的影响。搭建了基于 FPGA(Field Programmable Gate Array)的数字有源 EMI 控制系统平台,验证了具有延迟特性的数字有源EMI 滤波系统模型的正确性,揭示了数字有源 EMI 滤波系统延迟环节对滤波性能的影响规律,这有助于对数字有源EMI 滤波器的进一步研究和推广应用。

  4. Research on Simulation of Bioaerosols Diffusion in a Housing Estate%城市小区环境生物剂气溶胶的扩散模拟研究

    Institute of Scientific and Technical Information of China (English)

    刘健; 祖正虎; 许晴; 张文斗; 郑涛

    2012-01-01

    目的:研究城市小区中生物剂气溶胶的扩散模拟和污染区域的划分,为反生物恐怖危害评估及应急响应提供决策依据.方法:以典型生物剂炭疽为例,利用计算流体力学中的离散相模型对小区环境中生物剂气溶胶的扩散规律进行研究;对扩散后生物剂气溶胶的数目分布进行量化分析,结合吸入式炭疽的剂量-反应模型进行污染区域的划分.结果:通过计算机模拟,得到了生物剂气溶胶在小区环境中的扩散规律及数目分布,并依据人员感染炭疽概率的不同划分出小区内的污染区域.结论:利用离散相模型和剂量-反应模型,可以对城市小区中生物剂气溶胶的扩散规律进行模拟并划分污染区域,为反生物恐怖危害评估及应急响应提供决策依据.%Objective: Simulation of bioaerosols diffusion and division of contaminated areas were researched in this study, providing decision-making foundation according to which hazard assessment and emergency response against bioterrorism can be performed. Methods: Taking anthrax as an example, we did research on the diffusion of bioaerosols in a housing estate, using discrete phase model in computational fluid dynamics (CFD); we also made a quantitative analysis on the distribution of bioaerosols after the diffusion, and divided different contaminated areas using inhalation anthrax dose-response model. Results: Through computational simulation, the diffusion of bioaerosols in a housing estate was revealed, and different contaminated areas were divided according to the probability of infection. Conclusion: Using discrete phase model and dose-response model, bioaerosols diffusion in a housing estate can be simulated and division of contaminated areas can be made, which will provide decision-making foundation according to which hazard assessment and emergency response against bioterrorism can be performed.

  5. Structural analysis of the ParR/parC plasmid partition complex

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Ringgaard, Simon; Mercogliano, Christopher P;

    2007-01-01

    Accurate DNA partition at cell division is vital to all living organisms. In bacteria, this process can involve partition loci, which are found on both chromosomes and plasmids. The initial step in Escherichia coli plasmid R1 partition involves the formation of a partition complex between the DNA....... coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic...

  6. Evaluation of the PAR corneal topography system

    Science.gov (United States)

    Jindal, Prateek; Cheung, Susan; Pirouzian, Amir; Keates, Richard H.; Ren, Qiushi

    1995-05-01

    The purpose of this study was to evaluate the raster photogrammetry based Corneal Topography System by determining: inter-operator variability, reproducibility of images, effects of defocused and decentered images, and the precision of data at different optical zones. 4 human cadaver eyes were used to study the inter-operator variability. To study the reproducibility of images, 3 human cadaver eyes and a test surface doped with flourescine (provided by PAR Vision Systems Corporation) were focused and their images taken four successive times. Defocused and decentered images were taken of 4 human cadaver eyes and four times of the test surface mentioned above. The precision of defocused/decentered cadaver eyes was evaluated at the following optical zones: 3 mm, 4 mm, 5 mm, and 6 mm. All human cadaver eyes used in the above experiments had their epithelial layer removed before imaging. Average inter-operator variability was 0.06 D. In reproducibility attempts, there was an average deviation of 0.28 D for the human cadaver eyes and 0.04 D for the test surface. The defocused and decentered test surface gave an average deviation of 0.09 D. Defocused and decentered cadaver eyes resulted in an average deviation of 0.52 D, 0.37 D, 0.24 D, and 0.22 D at optical zones of 3 mm, 4 mm, 5 mm, and 6 mm, respectively. The imaging method employed by PAR Vision Systems Corporation virtually eliminates inter-operator variability. The PAR Corneal Topography System's clinical usefulness, however, could be improved by improving the reproducibility of images, decreasing the sensitivity to spatial alignment, and increasing accuracy over smaller optical zones.

  7. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  8. Modelisation par elements finis du muscle strie

    Science.gov (United States)

    Leonard, Mathieu

    Ce present projet de recherche a permis. de creer un modele par elements finis du muscle strie humain dans le but d'etudier les mecanismes engendrant les lesions musculaires traumatiques. Ce modele constitue une plate-forme numerique capable de discerner l'influence des proprietes mecaniques des fascias et de la cellule musculaire sur le comportement dynamique du muscle lors d'une contraction excentrique, notamment le module de Young et le module de cisaillement de la couche de tissu conjonctif, l'orientation des fibres de collagene de cette membrane et le coefficient de poisson du muscle. La caracterisation experimentale in vitro de ces parametres pour des vitesses de deformation elevees a partir de muscles stries humains actifs est essentielle pour l'etude de lesions musculaires traumatiques. Le modele numerique developpe est capable de modeliser la contraction musculaire comme une transition de phase de la cellule musculaire par un changement de raideur et de volume a l'aide des lois de comportement de materiau predefinies dans le logiciel LS-DYNA (v971, Livermore Software Technology Corporation, Livermore, CA, USA). Le present projet de recherche introduit donc un phenomene physiologique qui pourrait expliquer des blessures musculaires courantes (crampes, courbatures, claquages, etc.), mais aussi des maladies ou desordres touchant le tissu conjonctif comme les collagenoses et la dystrophie musculaire. La predominance de blessures musculaires lors de contractions excentriques est egalement exposee. Le modele developpe dans ce projet de recherche met ainsi a l'avant-scene le concept de transition de phase ouvrant la porte au developpement de nouvelles technologies pour l'activation musculaire chez les personnes atteintes de paraplegie ou de muscles artificiels compacts pour l'elaboration de protheses ou d'exosquelettes. Mots-cles Muscle strie, lesion musculaire, fascia, contraction excentrique, modele par elements finis, transition de phase

  9. Técnicas de filtrado de IEM en convertidores electrónicos de potencia EMI filter techniques in power electronic converters

    Directory of Open Access Journals (Sweden)

    Cano Plata Eduardo Antonio

    2010-08-01

    Full Text Available En este artículo se presentan los resultados de la aplicación de algunas técnicas de reducción de EMI en convertidores electrónicos de potencia. Las técnicas aplicadas incluyen el apantallamiento de señales de control y de potencia, la separación de las referencias del sistema de potencia de las señales y medidas, la implementación de filtros análogos y la configuración de un adecuado sistema de disparo, de tal forma que se disminuyan al máximo las emisiones tipo IEM. En este artículo se presentan los resultados obtenidos antes y después de aplicar las técnicas de reducción de interferencias. Además los resultados son verificados usando dos técnicas de control en tiempo real RCP (Rapid Control Prototy- ping.This paper presents the results of EMI reduction techniques applied to power electronic converters. The techniques applied included shielding control and power signals, separating power system references regarding reference for instrumentation and measurement signals, implementing analog filters and configuring an appropriate switch trigger system for electronic power to decrease shifting EMI emissions to the maximum. This paper presents the results before and after applying the techniques to reduce interference. The results were also veryfied by using two real time control strategies rapid control prototyping (RCP.

  10. A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, Kevin M.; Crosson, Sean (UC)

    2010-05-06

    Toxin-antitoxin (TA) systems form a ubiquitous class of prokaryotic proteins with functional roles in plasmid inheritance, environmental stress response, and cell development. ParDE family TA systems are broadly conserved on plasmids and bacterial chromosomes and have been well characterized as genetic elements that promote stable plasmid inheritance. We present a crystal structure of a chromosomally encoded ParD-ParE complex from Caulobacter crescentus at 2.6 {angstrom} resolution. This TA system forms an {alpha}{sub 2}{beta}{sub 2} heterotetramer in the crystal and in solution. The toxin-antitoxin binding interface reveals extensive polar and hydrophobic contacts of ParD antitoxin helices with a conserved recognition and binding groove on the ParE toxin. A cross-species comparison of this complex structure with related toxin structures identified an antitoxin recognition and binding subdomain that is conserved between distantly related members of the RelE/ParE toxin superfamily despite a low level of overall primary sequence identity. We further demonstrate that ParD antitoxin is dimeric, stably folded, and largely helical when not bound to ParE toxin. Thus, the paradigmatic model in which antitoxin undergoes a disorder-to-order transition upon toxin binding does not apply to this chromosomal ParD-ParE TA system.

  11. Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

    OpenAIRE

    Di Fiore, Barbara; Pines, Jonathon

    2007-01-01

    Ubiquitin-mediated proteolysis is critical for the alternation between DNA replication and mitosis and for the key regulatory events in mitosis. The anaphase-promoting complex/cyclosome (APC/C) is a conserved ubiquitin ligase that has a fundamental role in regulating mitosis and the cell cycle in all eukaryotes. In vertebrate cells, early mitotic inhibitor 1 (Emi1) has been proposed as an important APC/C inhibitor whose destruction may trigger activation of the APC/C at mitosis. However, in t...

  12. New Designs in shielding check EMI at board level%屏蔽新设计抑制板级电磁干扰

    Institute of Scientific and Technical Information of China (English)

    Norman Quesnel

    2001-01-01

    @@ 对印刷线路板进行适当的线路布局是解决辐射电磁干扰(EMI)问题最省钱的方法.目前有几种商业软件可以分析潜在的板级电磁干扰问题.不过,用软件并不一定可靠,为优化设计,经常需要对样品进行板级测试和反复的布线.

  13. Evaluation of children as sources of bioaerosols in a climate chamber study. [Staphylococcus epidermidis; Saprophyticus; Bacillus spp. ; Bacillus megaterium; Acinetobacter spp

    Energy Technology Data Exchange (ETDEWEB)

    Lundqvist, G.R.; Aalykke, C.; Bonde, G.J. (Univ. of Aarhus (Denmark))

    1990-01-01

    Emissions of viable particles from a group of children were measured under controlled conditions in a climate chamber that simulated indoor environmental exposure in day-care institutions with tight building envelopes and outdoor air supply by natural infiltration only. Bioaerosol sampling was simultaneously applied with slit samplers and sediment plates. A total of 142 strains was identified. Most of these were from sediment plates (95%) as the colonies on the slit sampler were more crowded and too confluent for separation. On sediment plates, coryneform bacteria dominated (27-85%), followed in frequency by micrococci (4-50%), Staphylococcus epidermidis and saprophyticus (12-43%), Bacillus spp., most frequently B. megaterium (12-33%), and Acinetobacter spp. (11-14%). From the slit sampler plates, staphylococci dominated (67%), followed by coryneform species and micrococci (17%). Within the first hour after the group left the chamber, the number of colony forming units (CFU) suspended in the air decreased, corresponding to an equivalent dilution ventilation rate of 2.0 ACH (air changes per hour) for bacteria and 1.7 ACH for mold spores due to the catching of particles on surfaces and to die away of viable microorganisms. Accordingly, microbial surface contamination revealed an increase at the same time.

  14. Origin of low δ26Mg basalts with EM-I component: Evidence for interaction between enriched lithosphere and carbonated asthenosphere

    Science.gov (United States)

    Tian, Heng-Ci; Yang, Wei; Li, Shu-Guang; Ke, Shan; Chu, Zhu-Yin

    2016-09-01

    This study presents stable Mg isotopic data for Cenozoic potassic basalts from Wudalianchi and Erkeshan in northeastern China to determine the interactions between upwelling carbonated asthenosphere and enriched lithospheric mantle. Although the Wudalianchi and Erkeshan basalts have variable MgO contents of 4.45 to 9.47 wt.%, they exhibit a homogeneous Mg isotopic composition with δ26Mg values ranging from -0.57‰ to -0.46‰ and averaging -0.51 ± 0.06‰ (2SD, n = 18). This Mg isotopic composition is lighter than that of the average mantle (δ26Mg = -0.25 ± 0.07‰) but similar to late Cretaceous (lithospheric mantle. Therefore, an asthenosphere-lithosphere interaction model is proposed for determine the origin of the Wudalianchi and Erkeshan basalts. The original melt was derived from partial melting of the carbonated asthenospheric mantle that was metasomatized by carbonate melt from the stagnant Pacific slab in the mantle transition zone. This ascending melt with a low δ26Mg signature subsequently interacted with the EM-I lithospheric mantle. The interaction dissolved pyroxene and crystallized olivine, releasing LILE, REE, Sr and Pb from dissolved minerals into the melt. Simultaneously, Mg was inherited by newly formed olivine. Therefore, this interaction modified the trace elements and the Sr-Nd-Pb isotopic compositions of the melt toward EM-I geochemical features but preserved the light Mg isotope signatures.

  15. Sr, Nd, and Pb isotopes of ultramafic xenoliths in volcanic rocks of Eastern China: enriched components EMI and EMII in subcontinental lithosphere

    Science.gov (United States)

    Tatsumoto, M.; Basu, A.R.; Wankang, H.; Junwen, W.; Guanghong, X.

    1992-01-01

    The UThPb, SmNd, and RbSr isotopic systematics of mafic and ultramafic xenolithic rocks and associated megacrystic inclusions of aluminous augite and garnet, that occur in three alkalic volcanic suites: Kuandian in eastern Liaoning Province, Hanluoba in Hebei Province, and Minxi in western Fujian Province, China are described. In various isotopic data plots, the inclusion data invariably fall outside the isotopic ranges displayed by the host volcanic rocks, testifying to the true xenolithic nature of the inclusions. The major element partitioning data on Ca, Mg, Fe, and Al among the coexisting silicate minerals of the xenoliths establish their growth at ambient mantle temperatures of 1000-1100??C and possible depths of 70-80 km in the subcontinental lithosphere. Although the partitioning of these elements reflects equilibrium between coexisting minerals, equilibria of the Pb, Nd, and Sr isotopic systems among the minerals were not preserved. The disequilibria are most notable with respect to the 206Pb 204Pb ratios of the minerals. On a NdSr isotopic diagram, the inclusion data plot in a wider area than that for oceanic basalts from a distinctly more depleted component than MORB with higher 143Nd 144Nd and a much broader range of 87Sr 86Sr values, paralleling the theoretical trajectory of a sea-water altered lithosphere in NdSr space. The garnets consistently show lower ?? and ?? values than the pyroxenes and pyroxenites, whereas a phlogopite shows the highest ?? and ?? values among all the minerals and rocks studied. In a plot of ??207 and ??208, the host basalts for all three areas show lower ??207 and higher ??208 values than do the xenoliths, indicating derivation of basalts from Th-rich (relative to U) sources and xenoliths from U-rich sources. The xenolith data trends toward the enriched mantle components, EMI and EMII-like, characterized by high 87Sr 86Sr and ??207 values but with slightly higher 143Nd 144Nd. The EMI trend is shown more distinctly by the host

  16. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells w...

  17. Identification des gaz combustibles par capteur catalytique

    OpenAIRE

    Rose, Gérard

    1995-01-01

    L'explosimètre est un instrument destiné à prévenir le risque d'inflammation d'un mélange d'air et de gaz en informant de la présence du gaz par une alarme, et en délivrant une mesure qu'il exprime en pourcentage de la limite inférieure d'explosivité du mélange (LIE). Il répond à tous les gaz et vapeurs combustibles, mais il ne donne une mesure juste que pour un seul d'entre-eux : celui pour lequel il a été étalonné. Cet inconvénient est sans conséquence si l'utilisateur identifie le gaz, car...

  18. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  19. Taare Zameen Par and dyslexic savants

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  20. Study of mechanisms of the formation of specific pollutants emitted by internal combustion engines; Etude des mecanismes de formation des polluants specifiques emis par les moteurs a combustion interne

    Energy Technology Data Exchange (ETDEWEB)

    Zervas, E.

    1996-06-26

    Methods for the analysis on sulfur dioxide, alcohols and organic acids have been developed. The first one includes the capture of the sulfur dioxide in a solution of oxygenated water and the analysis bu ionic chromatography with a conductometric detector. The second one includes the capture in pure water and an analysis bu gas chromatography/flame ionisation detector. The third one uses the capture in pure water and the analysis of the formic acid by an ionic chromatography and of the other acids by gas chromatography. These methods have been applied in the case of vehicles` non-regulated pollutants research. An experiment design, combined specified fuels and analysis of the exhaust gazes, has been applied on a spark ignition engine. These tests proved several qualitative and quantitative correlations between the composition of the fuel and the emitted pollutants. Precursors of hydrocarbons, aldehydes, ketones, alcohols and organic acids have been found. These results show that aromatics and cyclohexane contribute for the benzene`s formation, 1-hexene and cyclohexane for the 1,3 butadiene`s, aromatics, are the precursors of the propionic acid and 0-xylene of the butyric acid. (author)

  1. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  2. Contribution a l'industrialisation du soudage par friction malaxage

    OpenAIRE

    Zimmer, Sandra

    2009-01-01

    Le soudage par friction malaxage, ou FSW, est un procédé de soudage à l'« état solide » permettant d'éviter certains problèmes rencontrés en soudage par fusion comme la fissuration à chaud ou la création de soufflures. La soudure est réalisée par l'action d'un outil à l'interface de deux pièces à souder. Celui-ci a pour rôle de malaxer et d'échauffer par frottement la matière. Le cordon est réalisé de proche en proche. Les efforts générés à l'interface outil/matière doivent être repris par la...

  3. Recombination in the human Pseudoautosomal region PAR1.

    Science.gov (United States)

    Hinch, Anjali G; Altemose, Nicolas; Noor, Nudrat; Donnelly, Peter; Myers, Simon R

    2014-07-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome. PMID:25033397

  4. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  5. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  6. BioAerosol Mass Spectrometry: Reagentless Detection of Individual Airborne Spores and Other Bioagent Particles Based on Laser Desorption/Ionization Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Steele, Paul Thomas [Univ. of California, Davis, CA (United States)

    2004-09-01

    Better devices are needed for the detection of aerosolized biological warfare agents. Advances in the ongoing development of one such device, the BioAerosol Mass Spectrometry (BAMS) system, are described here in detail. The system samples individual, micrometer-sized particles directly from the air and analyzes them in real-time without sample preparation or use of reagents. At the core of the BAMS system is a dual-polarity, single-particle mass spectrometer with a laser based desorption and ionization (DI) system. The mass spectra produced by early proof-of-concept instruments were highly variable and contained limited information to differentiate certain types of similar biological particles. The investigation of this variability and subsequent changes to the DI laser system are described. The modifications have reduced the observed variability and thereby increased the usable information content in the spectra. These improvements would have little value without software to analyze and identify the mass spectra. Important improvements have been made to the algorithms that initially processed and analyzed the data. Single particles can be identified with an impressive level of accuracy, but to obtain significant reductions in the overall false alarm rate of the BAMS instrument, alarm decisions must be made dynamically on the basis of multiple analyzed particles. A statistical model has been developed to make these decisions and the resulting performance of a hypothetical BAMS system is quantitatively predicted. The predictions indicate that a BAMS system, with reasonably attainable characteristics, can operate with a very low false alarm rate (orders of magnitude lower than some currently fielded biodetectors) while still being sensitive to small concentrations of biological particles in a large range of environments. Proof-of-concept instruments, incorporating some of the modifications described here, have already performed well in independent testing.

  7. BioAerosol Mass Spectrometry: Reagentless Detection of Individual Airborne Spores and Other Bioagent Particles Based on Laser Desorption/Ionization Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Steele, P T

    2004-07-20

    Better devices are needed for the detection of aerosolized biological warfare agents. Advances in the ongoing development of one such device, the BioAerosol Mass Spectrometry (BAMS) system, are described here in detail. The system samples individual, micrometer-sized particles directly from the air and analyzes them in real-time without sample preparation or use of reagents. At the core of the BAMS system is a dual-polarity, single-particle mass spectrometer with a laser based desorption and ionization (DI) system. The mass spectra produced by early proof-of-concept instruments were highly variable and contained limited information to differentiate certain types of similar biological particles. The investigation of this variability and subsequent changes to the DI laser system are described. The modifications have reduced the observed variability and thereby increased the usable information content in the spectra. These improvements would have little value without software to analyze and identify the mass spectra. Important improvements have been made to the algorithms that initially processed and analyzed the data. Single particles can be identified with an impressive level of accuracy, but to obtain significant reductions in the overall false alarm rate of the BAMS instrument, alarm decisions must be made dynamically on the basis of multiple analyzed particles. A statistical model has been developed to make these decisions and the resulting performance of a hypothetical BAMS system is quantitatively predicted. The predictions indicate that a BAMS system, with reasonably attainable characteristics, can operate with a very low false alarm rate (orders of magnitude lower than some currently fielded biodetectors) while still being sensitive to small concentrations of biological particles in a large range of environments. Proof-of-concept instruments, incorporating some of the modifications described here, have already performed well in independent testing.

  8. Bioaerosol Dispersion in Relation with Wastewater Reuse for Crop Irrigation. (Experiments to understand emission processes with enteric virus and risks modeling).

    Science.gov (United States)

    Courault, D.; Girardin, G.; Capowiez, L.; Albert, I.; Krawczyk, C.; Ball, C.; Salemkour, A.; Bon, F.; Perelle, S.; Fraisse, A.; Renault, P.; Amato, P.

    2014-12-01

    Bio-aerosols consist of microorganisms or biological particles that become airborne depending on various environmental factors. Recycling of wastewater (WW) for irrigation can cope with the issues of water availability, and it can also threaten Human health if the pathogens present in WW are aerosolized during sprinkling irrigation or wind events. Among the variety of micro-organisms found in WW, enteric viruses can reach significant amounts, because most of the WW treatments are not completely efficient. These viruses are particularly resistant in the environment and responsibles of numerous digestive diseases (gastroenteritis, hepatitis…). Few quantities are enough to make people sick (102 pfu). Several knowledge gaps exist to better estimate the risks for Human exposure, and on the virus transfer from irrigation up to the respiratory track. A research program funded by the French government (INSU), gathering multi disciplinary teams aims at better understanding virus fate in air and health risks from WW reuse. Experiments were conducted under controlled conditions in order to prioritize the main factors impacting virus aerosolization. Irrigation with water loaded with safe surrogates of Hepatitis A virus (Murine Mengo Virus) was applied on small plots covered by channels in which the wind speed varied. Various situations have been investigated (wet/dry surfaces, strong/mild winds, clean/waste water). Air samples were collected above plots using impingers and filters after irrigation for several days. Viruses were quantified by RT-qPCR. The results showed that impingers were more efficient in airborne virus recovering than filters. Among environmental factors, Wind speed was the main factor explaining virus concentration in the air after irrigation. A Quantitative Microbial Risk Assessment approach has been chosen to assess the health effects on the population. The main modeling steps will be presented, including a simplified dispersion model coupled with a

  9. Comprehensive assignment of mass spectral signatures from individual Bacillus atrophaeus spores in matrix-free laser desorption/ionization bioaerosol mass spectrometry.

    Science.gov (United States)

    Srivastava, Abneesh; Pitesky, Maurice E; Steele, Paul T; Tobias, Herbert J; Fergenson, David P; Horn, Joanne M; Russell, Scott C; Czerwieniec, Gregg A; Lebrilla, Carlito B; Gard, Eric E; Frank, Matthias

    2005-05-15

    We have fully characterized the mass spectral signatures of individual Bacillus atrophaeus spores obtained using matrix-free laser desorption/ionization bioaerosol mass spectrometry (BAMS). Mass spectra of spores grown in unlabeled, 13C-labeled, and 15N-labeled growth media were used to determine the number of carbon and nitrogen atoms associated with each mass peak observed in mass spectra from positive and negative ions. To determine the parent ion structure associated with fragment ion peaks, the fragmentation patterns of several chemical standards were independently determined. Our results confirm prior assignments of dipicolinic acid, amino acids, and calcium complex ions made in the spore mass spectra. The identities of several previously unidentified mass peaks, key to the recognition of Bacillus spores by BAMS, have also been revealed. Specifically, a set of fragment peaks in the negative polarity is shown to be consistent with the fragmentation pattern of purine nucleobase-containing compounds. The identity of m/z = +74, a marker peak that helps discriminate B. atrophaeus from Bacillus thuringiensis spores grown in rich media is [N1C4H12]+. A probable precursor molecule for the [N1C4H12]+ ion observed in spore spectra is trimethylglycine (+N(CH3)3CH2COOH), which produces a m/z = +74 peak when ionized in the presence of dipicolinic acid. A clear assignment of all the mass peaks in the spectra from bacterial spores, as presented in this work, establishes their relationship to the spore chemical composition and facilitates the evaluation of the robustness of "marker" peaks. This is especially relevant for peaks that have been used to discriminate Bacillus spore species, B. thuringiensis and B. atrophaeus, in our previous studies. PMID:15889924

  10. Standoff detection of bioaerosols over wide area using a newly developed sensor combining a cloud mapper and a spectrometric LIF lidar

    Science.gov (United States)

    Buteau, Sylvie; Simard, Jean-Robert; Roy, Gilles; Lahaie, Pierre; Nadeau, Denis; Mathieu, Pierre

    2013-10-01

    A standoff sensor called BioSense was developed to demonstrate the capacity to map, track and classify bioaerosol clouds from a distant range and over wide area. The concept of the system is based on a two steps dynamic surveillance: 1) cloud detection using an infrared (IR) scanning cloud mapper and 2) cloud classification based on a staring ultraviolet (UV) Laser Induced Fluorescence (LIF) interrogation. The system can be operated either in an automatic surveillance mode or using manual intervention. The automatic surveillance operation includes several steps: mission planning, sensor deployment, background monitoring, surveillance, cloud detection, classification and finally alarm generation based on the classification result. One of the main challenges is the classification step which relies on a spectrally resolved UV LIF signature library. The construction of this library relies currently on in-chamber releases of various materials that are simultaneously characterized with the standoff sensor and referenced with point sensors such as Aerodynamic Particle Sizer® (APS). The system was tested at three different locations in order to evaluate its capacity to operate in diverse types of surroundings and various environmental conditions. The system showed generally good performances even though the troubleshooting of the system was not completed before initiating the Test and Evaluation (T&E) process. The standoff system performances appeared to be highly dependent on the type of challenges, on the climatic conditions and on the period of day. The real-time results combined with the experience acquired during the 2012 T & E allowed to identify future ameliorations and investigation avenues.

  11. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    over the nucleoid. ParB ribbon-helix-helix dimers bind cooperatively to direct repeats in parC1 and parC2. Using four different assays we obtain solid evidence that ParB can pair parC1- and parC2-encoding DNA fragments in vitro. Convincingly, electron microscopy revealed that ParB mediates binary...... pairing of parC fragments. In addition to binary complexes, ParB mediated the formation of higher order complexes consisting of several DNA fragments joined by ParB at centromere site parC. N-terminal truncated versions of ParB still possessing specific DNA binding activity were incompetent in pairing...

  12. Control of cleavage spindle orientation in Caenorhabditis elegans: The role of the genes par-2 and par-3

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, N.N.; Kirby, C.M.; Kemphues, K.J. [Cornell Univ., Ithaca, NY (United States)

    1995-02-01

    Polarized asymmetric divisions play important roles in the development of plants and animals. The first two embryonic cleavages of Caenorhabditis elegans provide an opportunity to study the mechanisms controlling polarized asymmetric divisions. The first cleavage is unequal, producing daughters with different sizes and fates. The daughter blastomeres divide with different orientations at the second cleavage; the anterior blastomere divides equally across the long axis of the egg, whereas the posterior blastomere divides unequally along the long axis. We report here the results of our analysis of the genes par-2 and par-3 with respect to their contribution to the polarity of these divisions. Strong loss-of-function mutations in both genes lead to an equal first cleavage and an altered second cleavage. Interestingly, the mutations exhibit striking gene-specific differences at the second cleavage. The par-2 mutations lead to transverse spindle orientations in both blastomeres, whereas par-3 mutations lead to longitudinal spindle orientations in both blastomeres. The spindle orientation defects correlate with defects in centrosome movements during both the first and the second cell cycle. Temperature shift experiments with par-2 (it5ts) indicate that the par-2(+) activity is not required after the two-cell stage. Analysis of double mutants shows that par-3 is epistatic to par-2. We propose a model wherein par-2(+) and par-3(+) act in concert during the first cell cycle to affect asymmetric modification of the cytoskeleton. This polar modification leads to different behaviors of centrosomes in the anterior and posterior and leads ultimately to blastomere-specific spindle orientations at the second cleavage. 44 refs., 5 figs., 5 tabs.

  13. 永磁交流伺服驱动系统共模EMI噪声的预测及抑制%Prediction and suppression of CM EMI in permanent magnet AC servo drives

    Institute of Scientific and Technical Information of China (English)

    余伟; 王世山; 虞振洋; 周峰

    2015-01-01

    With the constant increase of switching frequency in power electronic devices, the reliable operation of permanent AC servo drives working in sophisticated occasion is more and more easily influenced because of EMI produced by the mutual action of higher du/dt and di/dt with parasitic parameters. EMI modeling plays an impor⁃tant role in analyzing, predicting and suppressing EMI. Therefore, a method of predicting common mode EMI ( CM EMI) in permanent magnet AC servo drives is explored in this paper. As far as the IPM equipment in a typical sys⁃tem is concerned, its voltage of mid⁃leg jumps constantly. An equivalent model of CM EMI noise source is presen⁃ted by analyzing that phenomenon. The propagation path of CM EMI is stated, and then the high frequency parame⁃ters of the main parts ( including the power converter, shielded cable and Permanent Magnet Synchronous Motor (PMSM)) are extracted with different methods. In 150kHz~30MHz frequency range, actual measurement of CM EMI is completed. Compared with the simulation result, the validity of the proposed model is confirmed finally. The EMI noise of the prototype is measured. A method to suppress the noise is proposed, in which a planar EMI filter will be used. The final experimental measurement shows that this filter can greatly reduce the noise in this sys⁃tem.%永磁交流伺服驱动系统中高du/dt、di/dt在系统中寄生参数作用下感应出的电磁干扰,随着开关频率的不断提高,已逐渐影响到其在高精密场合下的可靠运行。电磁干扰( Electromagnetic In⁃terference, EMI)模型的研究,是电磁干扰分析、预测及其抑制的基础。本文研究出一种永磁交流伺服驱动系统共模EMI噪声的预估方案:针对典型系统中的智能功率模块( IPM )装置,通过分析开关管状态切换过程中IPM桥臂中点电位的跳变,等效出共模噪声源模型;在阐述共模干扰传播路径的基础上,利用不同

  14. Electrospun nanofiber and its application in bio-aerosol filtration%静电纺丝纳米纤维及其在生物气溶胶过滤中的应用

    Institute of Scientific and Technical Information of China (English)

    王润泽; 王政; 吴金辉; 王涛

    2013-01-01

    简要介绍了静电纺丝制备纳米纤维的原理以及纤维形态的主要影响因素;从静电纺丝纳米纤维的过滤效果、抗菌性能和力学性能等方面综述了其应用于生物气溶胀过滤材料的研究进展;指出静电纺丝纳米纤维大规模生产已取得突破,且抗菌改性效果持久,适合应用于生物气溶胀过滤领域,今后应进一步提高纳米纤维的力学性能及质量稳定性,具有良好的应用前景.%The principles of nanofiber preparation via electrospinning process were briefly introduced,as were the principal influential factors on the fiber morphology.The research progress in electrospun nanofiber as bio-aerosol filtration material was reviewed from the aspects of filtration efficiency,antibacterial property and mechanical properties.It was pointed out that a breakthrough had been achieved in the large-scale production of electrospun nanofiber which possessed a wonderful application prospect as a desirable bio-aerosol filtration material due to its lasting antibacterial modification effect,excellent mechanical properties and stable quality in the future.

  15. PAR elevation influence on hydrogen floor layer depth

    International Nuclear Information System (INIS)

    In order to circumvent problems associated with containment loads resulting from a possible hydrogen combustion, French containments for instance are equipped with passive autocatalytic recombiners (PAR). The aim of this safety device is to recombine hydrogen with oxygen in order to limit hydrogen concentration. Hence, PAR distribution within the containment is a key feature to limit the hydrogen risk. According with the PARIS benchmark scenario and boundary conditions therein (EU-FP6, SARNET project) a floor layer developed with low mass and thermal mixing processes. In this paper we illustrate the link between the PAR elevation and the floor layer depth. (author)

  16. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  17. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle;

    2015-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response...... analysis shoved an AUC of 0.76 at 6 hours. In the subgroup of CA of cardiac cause, the AUC was 0.84. CONCLUSION: suPAR levels at 6 and 36 hours after CA were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups...

  18. Técnicas de filtrado de IEM en convertidores electrónicos de potencia EMI filter techniques in power electronic converters

    OpenAIRE

    Cano Plata Eduardo Antonio; Hoyos Velasco Fredy Edimer; Younes Velosa Camilo

    2010-01-01

    En este artículo se presentan los resultados de la aplicación de algunas técnicas de reducción de EMI en convertidores electrónicos de potencia. Las técnicas aplicadas incluyen el apantallamiento de señales de control y de potencia, la separación de las referencias del sistema de potencia de las señales y medidas, la implementación de filtros análogos y la configuración de un adecuado sistema de disparo, de tal forma que se disminuyan al máximo las emisiones tipo IEM. En este artículo se pres...

  19. 使用屏蔽电缆减少牵引回路的电磁干扰%Reduction of EMI from traction circuits using shielded cable

    Institute of Scientific and Technical Information of China (English)

    Satoru Hatsukade; 何春

    2009-01-01

    电磁干扰(EMI)是铁道车辆牵引回路中电子电源方面无法避免的问题.由于很难减少来自各种设备和电缆中的电磁干扰,故将普通异步电动机电缆更换为屏蔽电缆,并研究其对降低辐射的影响.结果表明:电缆两端头屏蔽后,在100 kHz点干扰降低了10 dB.屏蔽电缆能有效降低牵引回路辐射,特别适用于不宜采用其他方法降低电磁干扰时,诸如跨接电缆或电动机引出线等.

  20. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

    Directory of Open Access Journals (Sweden)

    Dale Beverly A

    2010-10-01

    Full Text Available Abstract Background Protease-Activated Receptors (PARs, members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs, but the signaling pathways downstream of PAR activation in HOKs have not been clearly defined. In this study, we aimed to determine if PAR1- and PAR2-mediated signaling differs in the induction of innate immune markers CXCL3, CXCL5 and CCL20 via ERK, p38 and PI3K/Akt. Results Our data show the induction of innate immunity by PAR1 requires both p38 and ERK MAP kinases, while PAR2 prominently signals via p38. However, inhibition of PI3K enhances expression of innate immune markers predominantly via suppressing p38 phosphorylation signaled by PAR activation. Conclusion Our data indicate that proteases mediating PAR1 and PAR2 activation differentially signal via MAP kinase cascades. In addition, the production of chemokines induced by PAR1 and PAR2 is suppressed by PI3K/Akt, thus keeping the innate immune responses of HOK in balance. The results of our study provide a novel insight into signaling pathways involved in PAR activation.

  1. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene;

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...

  2. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine;

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models.......Degradation of proteins in the extracellular matrix is crucial for the multistep process of cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase receptor (uPAR) and its cognate ligand, the urokinase plasminogen activator (uPA), to play critical roles in the concerted...

  3. Determination of PARs capacity for HMS in EU APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Do Hyun [KHNP CRI, Daejeon (Korea, Republic of)

    2012-10-15

    The Hydrogen Mitigation System (HMS) is designed to control combustible gas, mainly hydrogen gas (H2) inside containment within the acceptable limits by the Passive Autocatalytic Recombiner (PAR) with consideration of hydrogen generation during severe accidents. In EU APR1400 (European APR1400), a passive hydrogen control system which is composed of a number of PARs, is adopted for the mitigation of the hydrogen induced risks. For the design of the HMS, the expected ranges for the global and local hydrogen concentrations in the containment and the increase rate of the concentrations should be examined to specify the required capacity and locations of the PARs. This paper describes the determination of PARs capacity for HMS in EU APR1400.

  4. A turquesa de Itacupim, Pará

    Directory of Open Access Journals (Sweden)

    Marcondes Lima da Costa

    2004-12-01

    Full Text Available Na ilha de Itacupim, localizada na região costeira do nordeste do Pará, foram encontrados veios de fosfatos de alumínio contendo turquesa, além de quartzo e argilominerais. A ilha é sustentada por espesso perfil laterítico maturo desenvolvido sobre complexo alcalino-ultramáfico mineralizado em apatita. Os veios e vênulas são de espessura centimétrica, normalmente constituídos de wavellita fibro-radial, onde pode ser observada turquesa verde-azulada, em massas subesferolíticas, microcristalinas, intercrescidas com caulinita e oxi-hidróxidos de Mn, além de quartzo. A identificação mineral foi realizada por DRX, microscopia óptica, análises químicas de rocha total, MEV/SED. Os teores de CuO são inferiores aos das turquesas em geral, compensados por Fe2O3 e ZnO. Os subesferolitos de turquesa contêm inúmeras inclusões micrométricas de goyazita ou svanbergita. A ocorrência da turquesa, na forma de veios e vênulas, seu aspecto porcelanado e a conhecida relação desse mineral com ambiente hidrotermal sugerem que a turquesa de Itacupim também seja de origem hidrotermal, reforçada pela sua associação com wavellita, goyazita ou svanbergita, quartzo e argilominerais. Ela não foi encontrada no perfil laterítico. Seu aspecto compacto e sua cor esverdeada abrem perspectivas para seu uso como mineral de gema.Veins and veinlets of aluminum phosphates with turquoise occur at the Itacupim Island in the coastal plain northeast the state of Pará. A thick mature lateritic iron crust rich in aluminum phosphates developed an apatite-bearing alkaline-ultramafic complex which constitutes the Island. The veins and veinlets are cm-thick, usually constituted by wavellite, fibrous to radialfibrous, with bony or porcelaneous aspect, and can turquoise. Pebbles of these phosphates inside of apatite-bearing ultramafic rocks are very common at the base of the hang wall, and locally form expressive agglomerates. Turquoise forms half spheroids and

  5. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  6. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  7. Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.

    Science.gov (United States)

    Sviripa, Vitaliy M; Burikhanov, Ravshan; Obiero, Josiah M; Yuan, Yaxia; Nickell, Justin R; Dwoskin, Linda P; Zhan, Chang-Guo; Liu, Chunming; Tsodikov, Oleg V; Rangnekar, Vivek M; Watt, David S

    2016-01-01

    Advanced prostate tumors usually metastasize to the lung, bone, and other vital tissues and are resistant to conventional therapy. Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, Glucose-regulated protein-78 (GRP78), found only on the surface of cancer cells. 3-Arylquinolines or "arylquins" induce normal cells to release Par-4 from the intermediate filament protein, vimentin and promote Par-4 secretion that targets cancer cells in a paracrine manner. A structure-activity study identified arylquins that promote Par-4 secretion, and an evaluation of arylquin binding to the hERG potassium ion channel using a [(3)H]-dofetilide binding assay permitted the identification of structural features that separated this undesired activity from the desired Par-4 secretory activity. A binding study that relied on the natural fluorescence of arylquins and that used the purified rod domain of vimentin (residues 99-411) suggested that the mechanism behind Par-4 release involved arylquin binding to multiple sites in the rod domain.

  8. 电流临界连续模式Boost PFC变换器最恶劣传导电磁干扰频谱分析%Worst Conducted EMI Spectrum of the Critical Conduction Mode Boost PFC Converter

    Institute of Scientific and Technical Information of China (English)

    季清; 阮新波; 叶志红

    2013-01-01

    The switching frequency of the Boost PFC converter in critical conduction mode varies in a line cycle. As a result, the conducted EMI spectra is difficult to be diagnosed, which makes the design on EMI filter complicated. By analyzing the harmonic spectrum of the voltage across the drain and source of the power switch, effect of the varied switching frequency on the peak, quasi-peak and average conducted EMI spectra of the CRM boost PFC converter was revealed. It is indicated that the fundamental harmonic dominates the low frequency noise of the conducted EMI spectrum. Based on the relationship between the duty cycle and the fundamental harmonic amplitude of the voltage across the power switch, the input voltage and load condition for the worst case of the conducted EMI spectrum of the CRM boost PFC converter was derived. It is demonstrated that the worst spectrum in the condition is identical. The theoretical analysis was verified by the experiment results.%由于开关频率在工频周期内变化,CRM Boost PFC变换器的传导电磁干扰(electromagnetic interference,EMI)频谱诊断和滤波器设计十分困难。通过分析CRM Boost PFC变换器开关管漏源极电压的谐波频谱,揭示开关频率变化对传导EMI峰值、准峰值和平均值频谱的影响,指出传导EMI频谱低频段的好坏取决于共模和差模干扰的基波幅值。依据占空比与开关管漏源极电压基波幅值的关系,推导 CRM Boost PFC变换器原始传导电磁干扰频谱最恶劣时的输入电压和负载条件,证明在该条件下变换器的传导电磁干扰频谱是相同的,并通过实验验证理论分析。

  9. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  10. Pars Planitis: Epidemiology, Clinical Characteristics, Management and Visual Prognosis.

    Science.gov (United States)

    Ozdal, Pinar Cakar; Berker, Nilufer; Tugal-Tutkun, Ilknur

    2015-01-01

    Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease. PMID:27051493

  11. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  12. Par-4 Down-regulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

    OpenAIRE

    Alvarez, James V.; Pan, Tien-chi; Ruth, Jason; Feng, Yi; Zhou, Alice; Pant, Dhruv; Grimley, Joshua S.; Wandless, Thomas J.; DeMichele, Angela; Chodosh, Lewis A.

    2013-01-01

    Most deaths from breast cancer result from tumor recurrence, but the mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is down-regulated during tumor recurrence and that Par-4 down-regulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor respon...

  13. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    , in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. MATERIALS AND METHODS: Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal...... nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. RESULTS: At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than...... in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  14. Analysis and Suppression on Radiated EMI Noise for Radio Frequency Identification Systems%射频识别系统电磁辐射干扰特征快速分析与抑制

    Institute of Scientific and Technical Information of China (English)

    颜伟; 赵阳; 王恩荣; 邓凌翔; 张宇环

    2012-01-01

    针对射频识别系统产生的辐射干扰噪声,提出了基于近场测量结合波阻抗分析的辐射机理快速分析方法与基于全电容高频电磁干扰(electromagneticinterference,EMI)滤波器的辐射噪声抑制方法,可避免苛刻复杂的电波暗室噪声检测和电磁屏蔽噪声抑制方法,具有简便、快速、经济等优点。标准测试表明:采用文中方法可有效抑制辐射干扰噪声,噪声抑制效果可达24dBμtV/m,满足GB9254ClassA标准,从而验证了方法的有效性。%In order to solve radiated electromagnetic interference generated by the radio frequency identification system, the convenient approach was proposed to diagnose the radiated EMI mechanism based on near-field measurement and suppress radiated EMI noise by utilizing radio frequency EMI filters. It can avoid the complicated EMI noise analysis and suppression methods such as 3-m anechoic chamber and electromagnetic shielding. The standard results show that RFID system can pass the GB 9254 Class A and the noise decrease 24 dB~tV/m by employing the suggested approaches, and thus good realization.

  15. 基于MCMC方法的生物气溶胶袭击施放源项参数反演%Source inversion of bioaerosol attack based on MCMC method

    Institute of Scientific and Technical Information of China (English)

    许晴; 祖正虎; 张文斗; 徐致靖; 黄培堂; 郑涛

    2012-01-01

    生物气溶胶施放源项参数反演是生物气溶胶袭击危害评估的反问题,对危害评估及应急响应具有重要指导意义.本文基于贝叶斯推理方法,利用生物传感器检测数据和正向大气扩散模型,构造似然函数,采用结合Metropolis-Hasting算法的马尔可夫链蒙特卡洛(Markov chain Monte Carlo,MCMC)抽样,对施放源位置、高度、施放剂量进行反演.统计分析表明,反演结果和初始源项参数设置吻合非常好,证明了方法的有效性.%The inversion of bioaerosol release source parameters is the inverse problem of hazard assessment of bioaerosol attacks,and is of great significance for hazard assessment and emergency response. Based on observations of biosensors and concentrations predicted by an atmospheric dispersion model, a likelihood function was assigned, with which the Markov chain Monte Carlo ( MCMC) sampling based on Bayesian inference was used to invert the source parameters, including the source location,source height,and dispersion strength, statistic analysis shows that the inversion results fit the initial source parameters very well. The validity of the method is proved.

  16. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    OpenAIRE

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  17. Terapia Miofuncional en pacientes con parálisis cerebral

    OpenAIRE

    Gónzalez Amigo, José

    2015-01-01

    En el presente trabajo, se va a llevar a cabo una visión de la parálisis cerebral desde el punto de vista de la motricidad. La parálisis cerebral es una patología que se caracteriza fundamentalmente por una alteración a nivel motriz, que puede afectar a las diferentes extremidades así como a los órganos involucrados en el habla. Estas limitaciones en la región orofacial pueden producir importantes distorsiones y como consecuencia el discurso puede resultar ininteligible para los interlocutore...

  18. La parálisis cerebral en el cine

    OpenAIRE

    Merino Marcos, María Lucila

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  19. Apprentissage par Renforcement Développemental en Robotique Autonome

    OpenAIRE

    Sarzyniec, Luc; Buffet, Olivier; Dutech, Alain

    2011-01-01

    National audience Cet article présente une approche développementale de l'apprentissage par renforcement dans un cadre de robotique autonome. Le but est de permettre au robot de tirer parti de la richesse de son environnement sans que cette richesse ne le noie sous trop d'information à traiter. L'idée principale testée ici est de faire croître les capacités perceptives et motrices de l'agent au fur et à mesure de l'apprentissage. Cette approche est combinée avec un apprentissage par renfor...

  20. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  1. Predicting Spectral and PAR Light Attenuation in Greenlandic Coastal Waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Stedmon, Colin A.; Markager, Stiig

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  2. Suppression technology research of PWM inverter EMI%PWM 变频器的 EMI抑制技术研究

    Institute of Scientific and Technical Information of China (English)

    郭攀锋; 李欣; 张红

    2015-01-01

    In view of the application of PWM inverter which commonly used in present market, we analyze the mecha-nism of electromagnetic interference ( EMI) from some aspects, including rectifier and inverter side and overvoltage. In this paper, the electromagnetic interference filter is introduced, and the parameters of the RLC filter are designed. The final LC-RLC cascade filter topology structure is put forward.Finally, simulation model is established by Matlab/Simulink, to verify the effectiveness of the electromagnetic interference suppression technique.%针对目前市场上常用的功率变频器———PWM变频器的应用,从几个方面分析了的其电磁干扰( EMI)产生机理,包括整流测、逆变侧和过电压产生。然后,介绍了几种常见滤波器,并对RLC滤波器参数进行设计,并提出了LC-RLC级联滤波器的拓扑结构。最后,利用Matlab/Simulink建立了相应的几种滤波器仿真模型,验证所设计的滤波器对了EMI抑制技术的有效性。

  3. 费尔蒙酒店及度假村与阿迪达斯及EMI Music合作推出尊贵运动体验

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    费尔蒙酒店及度假村(Fairmont Hotels&Resorts)最新推出的Fairmont Fit服务让旅客能轻松享用adidas运动服饰,本服务专门为尊贵会员而设,酒店员工把运动服饰及鞋履送到客房、健身中心或户外,为宾客带来更全面的住宿体验。此外,酒店亦与EMI Music合作,为宾客提供Creative Zen mp3播放器,让宾客在运动期间可随意选播现代、经典、摇滚及轻音乐等不同类型的歌曲,在跑步、散步及休息期间享受乐韵悠扬。

  4. Food for thought: Sub-fossil and fossil chelonian remains from Franchthi Cave and Megalopolis confirm a glacial refuge for Emys orbicularis in Peloponnesus (S. Greece)

    Science.gov (United States)

    Vlachos, Evangelos; Delfino, Massimo

    2016-10-01

    Peloponnesus peninsula (S. Greece) shows a remarkable extant chelonian fauna that has received considerable attention from a molecular and morphological point of view. Here we present new evidence from the fossil and sub-fossil record of two important sites in the area, Franchthi Cave and Megalopolis. The archaeological material from Franchthi Cave (Upper Paleolithic - Neolithic/latest Pleistocene - early Holocene) represents food remains from small game prey of the humans that inhabited the cave. The palaeontological material from Megalopolis (Late Pleistocene) comes from old and new excavations. The studied specimens, combined with information from molecular, climatic and zoological works, provide for the first time direct evidence for the presence of the European pond turtle, Emys orbicularis, in the glacial refuge of South Greece that was hypothesized on the basis of the results of molecular investigations. We also describe other chelonian taxa present in the localities, the Hermann's tortoise Testudo hermanni and the Balkan stripe-necked terrapin Mauremys rivulata, and review previously published chelonian material from Peloponnesus.

  5. Design and Application of Induction Cooker EMI Filter%电磁炉EMI滤波器的设计与应用

    Institute of Scientific and Technical Information of China (English)

    史延东; 张翔; 宁飞

    2006-01-01

    当电路中有电压存在时,在所有带电的元器件周围都会产生电场,当电路中有电流流过的时候,在所有载流体的周围都存在磁场,所有的电子和电气设备都是潜在的电磁干扰(EMI)源.本文在电磁干扰未到达被干扰设备前,根据其传播的特点,采用各种手段将传播切断或削弱,达到抑制干扰的目的.干扰经导线直接传导耦合到电路中是最常见的.抑制由导线直接传导的干扰,主要措施是串接滤波器.

  6. Problemes methodologiques poses par l'extraction et la recuperation des bacteries telluriques pour leur quantification par immunofluorescence

    OpenAIRE

    Crozat, Y.; Cleyet-Marel, Jean Claude

    1984-01-01

    Afin d’améliorer la valeur quantitative de la technique de dénombrement des bactéries telluriques (Rhizobium japonicum) par immunofluorescence, on compare différents modes d’extraction et de récupération. L’utilisation de membranes en polycarbonates (Nucléopores) supprime les 40 p. 100 de pertes occasionnées par les membranes cellulosiques (Millipores) classiquement employées. Parmi les différents floculants testés, Ca(OH)2/MgCO3(2/5) permet d’obtenir les meilleurs résultats. Cependant po...

  7. Limitation des populations de ravageurs de l’olivier par le recours à la lutte biologique par conservation

    OpenAIRE

    Warlop, Francois

    2006-01-01

    L’olivier est une culture relativement rustique, mais qui peut être fortement attaquée par la mouche Bactrocera oleae (Gmelin), son principal ravageur. Les parasitoïdes de cette mouche sont connus, mais leur impact sur les populations de Diptères demeure faible, faute d’aménagement adéquat du paysage et suite à une intensification abusive des pratiques culturales. Le programme d’installation de bandes florales mené par le Groupe de recherches en agriculture biologique qui a débuté en 2004 vis...

  8. Pollution par les nitrates: quels remèdes?

    OpenAIRE

    Zilliox, Lothaire; Schenck, Charles; Kobus, Helmut; Huwe, Bernd

    1990-01-01

    Au cours des dix dernières années, la pollution des eaux souterraines par les nitrates n'a cessé d'augmenter. Principale accussée: l'agriculture, l'application de méthodes de techniques culturales devrait permettre une meilleure gestion des engrais azotés.

  9. Radiative Transfer Code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    D Emmanuel; D Phillippe; C Malik

    2000-12-01

    The production of carbon in the ocean, the so-called primary production, depends on various physico- biological parameters: the biomass and nutrient amounts in oceans, the salinity and temperature of the water and the light available in the water column. We focus on the visible spectrum of the solar radiation defined as the Photosynthetically Active Radiation (PAR). We developed a model (Chami et al. 1997) to simulate the behavior of the solar beam in the atmosphere and the ocean. We first describe the theoretical basis of the code and the method we used to solve the radiative transfer equation (RTE): the successive orders of scattering (SO). The second part deals with a sensitivity study of the PAR just above and below the sea surface for various atmospheric conditions. In a cloudy sky, we computed a ratio between vector fluxes just above the sea surface and spherical fluxes just beneath the sea surface. When the optical thickness of the cloud increases this ratio remains constant and around 1.29. This parameter is convenient to convert vector flux at the sea surface as retrieved from satellite to PAR. Subsequently, we show how solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to 40% for extreme cases.

  10. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  11. PH motifs in PAR1&2 endow breast cancer growth.

    Science.gov (United States)

    Kancharla, A; Maoz, M; Jaber, M; Agranovich, D; Peretz, T; Grisaru-Granovsky, S; Uziely, B; Bar-Shavit, R

    2015-01-01

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26600192

  12. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    OpenAIRE

    Anna Gustafsson; Vjosa Ajeti; Lennart Ljunggren

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to ...

  13. Structural and environmental factors are associated with internalised homonegativity in men who have sex with men: findings from the European MSM Internet Survey (EMIS) in 38 countries.

    Science.gov (United States)

    Berg, Rigmor C; Ross, Michael W; Weatherburn, Peter; Schmidt, Axel J

    2013-02-01

    Internalised homonegativity refers to a gay person's negative feelings about homosexuality and is believed to stem from negative societal stereotypes and attitudes towards homosexuality. Surprisingly, little research has centred on this link. In this research, we aimed to examine the associations between internalised homonegativity and structural forces, cultural influence, and access to sexual health promotion measures among a sample of 144,177 men who have sex with men (MSM) in 38 European countries. Participants were recruited as part of the European MSM Internet Survey (EMIS) during 2010. It was a self-completion, multilingual Internet-based survey for men living in Europe who have sex with men and/or feel attracted to men. Assumed causal relations were tested through multiple regression models. Variables at the structure of rule-systems (macro-level) that were significantly and negatively associated with internalised homonegativity were the presence of laws recognising same-sex relationships and same-sex adoption. In the meso-level model, greater proportions of the population expressing that they would not like to have homosexuals as neighbours predicted higher internalised homonegativity. In the last model, five variables were significantly and negatively associated with internalised homonegativity: being exposed to HIV/STI information for MSM, access to HIV testing, access to STI testing, access to condoms, and experience of gay-related hostility. In turn, men who had tested for HIV in the past year evidenced lower internalised homonegativity. This is the largest and certainly most geographically diverse study to date to examine structural and environmental predictors of internalised homonegativity among MSM. Our results show that one insidious consequence of society's stigma towards homosexuals is the internalisation of that stigma by gay and bisexual men themselves, thus, drawing attention to the importance of promoting social equity for self

  14. Structural and environmental factors are associated with internalised homonegativity in men who have sex with men: findings from the European MSM Internet Survey (EMIS) in 38 countries.

    Science.gov (United States)

    Berg, Rigmor C; Ross, Michael W; Weatherburn, Peter; Schmidt, Axel J

    2013-02-01

    Internalised homonegativity refers to a gay person's negative feelings about homosexuality and is believed to stem from negative societal stereotypes and attitudes towards homosexuality. Surprisingly, little research has centred on this link. In this research, we aimed to examine the associations between internalised homonegativity and structural forces, cultural influence, and access to sexual health promotion measures among a sample of 144,177 men who have sex with men (MSM) in 38 European countries. Participants were recruited as part of the European MSM Internet Survey (EMIS) during 2010. It was a self-completion, multilingual Internet-based survey for men living in Europe who have sex with men and/or feel attracted to men. Assumed causal relations were tested through multiple regression models. Variables at the structure of rule-systems (macro-level) that were significantly and negatively associated with internalised homonegativity were the presence of laws recognising same-sex relationships and same-sex adoption. In the meso-level model, greater proportions of the population expressing that they would not like to have homosexuals as neighbours predicted higher internalised homonegativity. In the last model, five variables were significantly and negatively associated with internalised homonegativity: being exposed to HIV/STI information for MSM, access to HIV testing, access to STI testing, access to condoms, and experience of gay-related hostility. In turn, men who had tested for HIV in the past year evidenced lower internalised homonegativity. This is the largest and certainly most geographically diverse study to date to examine structural and environmental predictors of internalised homonegativity among MSM. Our results show that one insidious consequence of society's stigma towards homosexuals is the internalisation of that stigma by gay and bisexual men themselves, thus, drawing attention to the importance of promoting social equity for self

  15. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob;

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA...

  16. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    Science.gov (United States)

    Gustafsson, Anna; Ajeti, Vjosa; Ljunggren, Lennart

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to plasma suPAR, CRP, BMI, or gender. Blood and unstimulated whole saliva was collected from 20 healthy individuals (10 female and 10 male, median age of 28 years; range 21–41). CRP and suPAR were measured with ELISA in saliva and serum/plasma. suPAR was detected in all saliva samples in the 5.2–28.1 ng/mL range, with a median value of 17.1 ng/mL. Saliva suPAR was significantly higher (P < 0.001) but not correlated to plasma suPAR in healthy young adults with normal plasma suPAR levels. suPAR and CRP levels were correlated in blood but not in saliva. No correlation was found between BMI, age, or gender and suPAR in saliva. PMID:22084570

  17. ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

    Science.gov (United States)

    The small serine resolvase ParA from bacterial plasmids RK2 and RP4 catalyzes the recombination of two identical 133 bp recombination sites known as MRS. Previously, we reported that ParA is active in the fission yeast Schizosaccharomyces pombe. In this work, the parA recombinase gene was placed un...

  18. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

    NARCIS (Netherlands)

    J.W.R. Hovius; M.F. Bijlsma; G.J.W. van der Windt; W.J. Wiersinga; B.J.D. Boukens; J. Coumou; A. Oei; R. de Beer; A.F. de Vos; C. van 't Veer; A.P. van Dam; P. Wang; E. Fikrig; M.M. Levi; J.J.T.H. Roelofs; T. van der Poll

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also

  19. Is There an "F" in Your PAR? Understanding, Teaching and Doing Action Research

    Science.gov (United States)

    Lorenzetti, Liza; Walsh, Christine Ann

    2014-01-01

    Participatory Action Research (PAR) is increasingly recognized within academic research and pedagogy. What are the benefits of including feminism within participatory action research and teaching? In responding to this question, we discuss the similarities and salient differences between PAR and feminist informed PAR (FPAR). There are eight themes…

  20. ParCAT: A Parallel Climate Analysis Toolkit

    Science.gov (United States)

    Haugen, B.; Smith, B.; Steed, C.; Ricciuto, D. M.; Thornton, P. E.; Shipman, G.

    2012-12-01

    Climate science has employed increasingly complex models and simulations to analyze the past and predict the future of our climate. The size and dimensionality of climate simulation data has been growing with the complexity of the models. This growth in data is creating a widening gap between the data being produced and the tools necessary to analyze large, high dimensional data sets. With single run data sets increasing into 10's, 100's and even 1000's of gigabytes, parallel computing tools are becoming a necessity in order to analyze and compare climate simulation data. The Parallel Climate Analysis Toolkit (ParCAT) provides basic tools that efficiently use parallel computing techniques to narrow the gap between data set size and analysis tools. ParCAT was created as a collaborative effort between climate scientists and computer scientists in order to provide efficient parallel implementations of the computing tools that are of use to climate scientists. Some of the basic functionalities included in the toolkit are the ability to compute spatio-temporal means and variances, differences between two runs and histograms of the values in a data set. ParCAT is designed to facilitate the "heavy lifting" that is required for large, multidimensional data sets. The toolkit does not focus on performing the final visualizations and presentation of results but rather, reducing large data sets to smaller, more manageable summaries. The output from ParCAT is provided in commonly used file formats (NetCDF, CSV, ASCII) to allow for simple integration with other tools. The toolkit is currently implemented as a command line utility, but will likely also provide a C library for developers interested in tighter software integration. Elements of the toolkit are already being incorporated into projects such as UV-CDAT and CMDX. There is also an effort underway to implement portions of the CCSM Land Model Diagnostics package using ParCAT in conjunction with Python and gnuplot. Par

  1. Development of a micro-circumstance airtight cabin for bioaerosol testing%一种用于生物气溶胶检测的微环境密闭舱室的研制

    Institute of Scientific and Technical Information of China (English)

    李娜; 温占波; 杨文慧; 王洁; 胡凌飞; 张柯; 李劲松

    2015-01-01

    Objective To develop a micro-circumstance airtight cabin for in the study of biological aerosols detection with such functions as airflow control and temperature and humidity detection .Methods Wind speed sensors , temperature and humidity sensors , electrical control valves , high efficiency filters and the vacuum pump formed the micro-circumstance regulating system .The techniques of airflow direction control , temperature compensation , air pressure control and aerosol uniformity distribution were used .Numerical simulation of aerosol concentration distribution in the airtight cabin was achieved using Fluent software .The bioaerosol concentration in different locations was tested by experiments .Results The micro-circumstance airtight cabin consisted of an airtight cabin and a control cabin .The control cabin used a single-chip microprocessor to provide air supply and exhaust air to the airtight cabin in a seaparate exhaust mode and cyclic ventilation mode.It worked under a negative pressure condition .Through numerical simulation,the aerosols were distributed through-out the cabin after five minutes of generation and the bottom airflow arrived at the top .The distribution of aerosol concentra-tion was approximately uniform .Conclusion The micro-circumstance airtight cabin is suited to various bioaerosols testing research thanks to its negative pressure working without bioaerosol leakage .%目的:研制一种具备气流控制和温湿度检测功能的微环境密闭舱室用于生物气溶胶检测研究。方法利用风速传感器、温湿度传感器、电动调节阀、管道高效过滤器和真空泵组成控制系统,解决气流流向控制、温度补偿技术、压力控制和气溶胶均匀分布技术。利用Fluent 软件对该密闭舱室气溶胶浓度分布状况进行数值模拟,并测试不同位置的气溶胶浓度。结果该微环境密闭舱室由一个气密舱和一个控制柜组成,控制柜采用单片机控制,并

  2. Valorisation de biogaz pour industrie chimie par voie catalytique

    OpenAIRE

    Taimoor, Aqeel Ahmad

    2010-01-01

    La production de l'hydrogène à partir de biomasse est actuellement à l'étude mais la méthode de valorisation du biogaz (mélange H2/CO2) par réactions catalytiques, autres que la simple combustion, n'a pas encore été retenue. Par conséquent, le principal objectif de ce travail est d'explorer les autres voies. L'effet du CO2 sur le système catalytique est mal connu et seulement un effet négatif sur la dissociation de l'hydrogène a été mentionné. L'hydrogénation du toluène sur un catalyseur Pt a...

  3. Des guides touristiques pour le peuple et par le peuple

    Directory of Open Access Journals (Sweden)

    Ninon Vinsonneau

    2006-04-01

    Full Text Available Le Federal Writers’ Project (FWP constitua l’un des quatre programmes « culturels » lancés par l’administration du New Deal en 1935 en vue de résorber le problème du chômage parmi les professions dites « en col blanc ». Il employa de 1935 à 1943, entre quatre et six mille chômeurs par an, tous membres des « professions de l’écrit » — les « écrivains », au sens large que l’administration fédérale donnait à ce terme : romanciers, poètes, dramaturges, mais aussi journalistes, enseignants, cherc...

  4. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  5. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    OpenAIRE

    Mutoh T; Kadoya K; Chikuda M

    2012-01-01

    Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females) after 25-gauge pars plana vitrectomy (PPV). One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedu...

  6. «La Promenade par les aventures surprenants»

    OpenAIRE

    Duarte, Alexandre Freire

    2010-01-01

    É nossa intenção, neste estudo, focar a atenção heurística no par: Jean-Joseph Surin (1600-1665), e Michel de Certeau, um homem que, intermitentemente – revelando uma vida queimada pelo fascínio por Jean-Joseph Surin –, constituiu, nas nossas mãos atentamente vazias, num vasto arvoredo que nos remetia continuamente para uma sombria clareira luminosa que irradiava do meio daquele.

  7. The ParMol package for frequent subgraph mining

    OpenAIRE

    Meinl, Thorsten; Wörlein, Marc; Urzova, Olga; Fischer, Ingrid; Philippsen, Michael

    2006-01-01

    Mining for frequent subgraphs in a graph database has become a popular topic in the last years. Algorithms to solve this problem are used in chemoinformatics to find common molecular fragments in a database of molecules represented as two-dimensional graphs. However; the search process in arbitrary graph structures includes costly graph and subgraph isomorphism tests. In our ParMol package we have implemented four of the most popular frequent subgraph miners using a common infrastructure: MoF...

  8. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were ...

  9. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH2, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  10. Diagnostic Ultrasound and Pars Plana Vitrectomy in Endophthalmitis

    Institute of Scientific and Technical Information of China (English)

    Jingjing Huang; Zhenfang Wang; Lijuan Zou; Xiaofeng Lin; Yiwen Luo; Zhaohui Yuan

    2004-01-01

    Purpose: To compare the results by B-scan ultrasonography and findings in pars plana vitrectomy, and assess the diagnostic value of B-scan ultrasonography in endophthalmitis.Methods: Thirty eyes of 30 subjects diagnosed as endophthalmitis were selected, who undergone preoperative B-scan ultrasonography. The result of pars plana vitrectomy was recorded. The above two results were compared.Results: On the evaluation of vitreous and retinal states in the patients with endophthalmitis, the sensitivity of ultrasound was 90%~100%, and the specificity was 79%~100%.Poorer preoperative visual acuity was related with retinal detachment and retinal dissolution. The preoperative visual acuity in eyes with local vitreous opacity was better than with diffuse vitreous opacity.Conclusion: Comparison of the results of B-scan ultrasonography and the findings in pars plana vitrectomy showed B-scan ultrasonography is highly sensitive, specific, and is very helpful in the evaluation of endophthalmitis. B-scan ultrasonography can not only supply much information in the diagnosis of endophthalmitis but also inspect its trends and changes, which is helpful in the selection of treatment and planning the time of surgery.

  11. Single-layer graphene-assembled 3D porous carbon composites with PVA and Fe₃O₄ nano-fillers: an interface-mediated superior dielectric and EMI shielding performance.

    Science.gov (United States)

    Rao, B V Bhaskara; Yadav, Prasad; Aepuru, Radhamanohar; Panda, H S; Ogale, Satishchandra; Kale, S N

    2015-07-28

    In this study, a novel composite of Fe3O4 nanofiller-decorated single-layer graphene-assembled porous carbon (SLGAPC) with polyvinyl alcohol (PVA) having flexibility and a density of 0.75 g cm(-3) is explored for its dielectric and electromagnetic interference (EMI) response properties. The composite is prepared by the solution casting method and its constituents are optimized as 15 wt% SLGAPC and 20 wt% Fe3O4 through a novel solvent relaxation nuclear magnetic resonance experiment. The PVA-SLGAPC-Fe3O4 composite shows high dielectric permittivity in the range of 1 Hz-10 MHz, enhanced by a factor of 4 as compared to that of the PVA-SLGAPC composite, with a reduced loss by a factor of 2. The temperature dependent dielectric properties reveal the activation energy behaviour with reference to the glass transition temperature (80 °C) of PVA. The dielectric hysteresis with the temperature cycle reveals a remnant polarization. The enhanced dielectric properties are suggested to be the result of improvement in the localized polarization of the integrated interface system (Maxwell-Wagner-Sillars (MWS) polarization) formed by the uniform adsorption of Fe3O4 on the surface of SLGAPC conjugated with PVA. The EMI shielding property of the composite with a low thickness of 0.3 mm in the X-band (8.2-12.4 GHz) shows a very impressive shielding efficiency of ∼15 dB and a specific shielding effectiveness of 20 dB (g cm(-3))(-1), indicating the promising character of this material for flexible EMI shielding applications. PMID:26105548

  12. A Novel GTEM Measurement Method for Radiated EMI Based on Noise Source Characteristics%基于电磁干扰源特征的GTEM辐射干扰测量方法

    Institute of Scientific and Technical Information of China (English)

    张宇环; 赵阳; 颜伟; 邱晓晖; 陈旸; 孙红艳; 娄鑫霞

    2013-01-01

    针对吉赫兹横电磁波(gigahertz transverse electromagnetic,GTEM)小室辐射电磁干扰(electromagnetic interference,EMI)测试精度较低及辐射源特征无法识别的问题,提出了基于Wilson算法、Lee算法和近场波阻抗理论的辐射源特征分析方法,并根据不同的辐射源特征分别提出了基于极差-均值算法的共模辐射噪声测试方法以及基于方差算法的差模辐射噪声测试方法.实验结果表明,利用文中方法能够有效判断辐射源特征,提高辐射EMI测试精度,为辐射EMI测试与分析提供理论依据.%A novel method is proposed to analyze the radiated source characteristic in gigahertz transverse electromagnetic (GTEM) based on the Wilson algorithm,the Lee algorithm and the near field wave impedance theory.According to the different radiated source mechanism,radiated electromagnetic interference (EMI) measurement approaches for the common mode and the differential mode noises are presented to improve the test accuracy by employing the range-mean algorithm and the variance algorithm,respectively.The experiment results show that the radiated source characteristic can be obtained and EMI measurements will be more accuracy in GTEM,which verified the effectiveness of suggested approaches.

  13. ParB Partition Proteins: Complex Formation and Spreading at Bacterial and Plasmid Centromeres.

    Science.gov (United States)

    Funnell, Barbara E

    2016-01-01

    In bacteria, active partition systems contribute to the faithful segregation of both chromosomes and low-copy-number plasmids. Each system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and all chromosomal centromere-binding proteins are dimeric helix-turn-helix DNA binding proteins, which are commonly named ParB. Although the overall sequence conservation among ParBs is not high, the proteins share similar domain and functional organization, and they assemble into similar higher-order complexes. In vivo, ParBs "spread," that is, DNA binding extends away from the parS site into the surrounding non-specific DNA, a feature that reflects higher-order complex assembly. ParBs bridge and pair DNA at parS and non-specific DNA sites. ParB dimers interact with each other via flexible conformations of an N-terminal region. This review will focus on the properties of the HTH centromere-binding protein, in light of recent experimental evidence and models that are adding to our understanding of how these proteins assemble into large and dynamic partition complexes at and around their specific DNA sites. PMID:27622187

  14. LabVIEW和小波算法在舰载电子设备EMI预测试中的应用%Application of LabVIEW and Wavelet Algorithm in the EMI Pretest of Shipboard Electronic Devices

    Institute of Scientific and Technical Information of China (English)

    吴楠; 侯冬云; 张嘉

    2011-01-01

    舰载电子设备电磁干扰(EMI)预测试通常是在测试环境和测试系统不能完全满足标准要求的情况下进行的,EMI测量数据会因为受到环境噪声的影响而导致无法有效识别受试设备(EUT)辐射信号,测试系统也会因为专用仪表的昂贵价格而受到制约.针对电子设备EMI预测试过程中环境噪声的来源和特征,分析了小波分析在消除环境噪声中的应用原理和方法,并利用LabVIEW虚拟仪器开发环境实现了高效灵活的数据采集及其与剔噪程序的接口.实验结果证明,该方法充分结合了LabVIEW和剔噪算法的优点,不仅对消除背景噪声有明显的效果,也降低了电子设备EMI预测试系统的成本.%The electromagnetic interference (EMI) pretest of shipboard electronic device is usually carried out under the conditions that the test environment and system cannot fully meet the requirements,the equipment under test(EUT) radiation signal may not be effectively identified due to the effect of ambient noise on the EMI test data, in addition, the expensive dedicated instruments also restrict the use of test system. This paper analyzes the approach of wavelet algorithm to eliminating the ambient noise considering source and characteristics in the EMI pretest process. High-efficient and flexible data acquisition and its interface with wavelet program for noise elimination are achieved by the use of secondary development environment of LabVIEW virtual device. The experimental results show that combining LabVIEW virtual device with the advantages of wavelet program has obvious effects on both elimination of background noise and cost reduction.

  15. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob;

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...... the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  16. The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation.

    Science.gov (United States)

    Khan, Aasma; Li, Dongjun; Ibrahim, Salam; Smyth, Emer; Woulfe, Donna S

    2014-07-01

    It is now well accepted that protease activated receptor (PAR) 1 and PAR4 have differential roles in platelet activation. PAR4, a low-affinity thrombin receptor in human platelets, participates in sustained platelet activation in a P2Y12-dependent manner; however, the mechanisms are not defined. Our previous studies demonstrated that thrombin induces the association of PAR4 with P2Y12, together with arrestin recruitment to the complex. Here we show that PAR4 and P2Y12 directly interact to coregulate Akt signaling after PAR4 activation. We observed direct and specific interaction of P2Y12 with PAR4 but not PAR1 by bioluminescent resonance energy transfer when the receptors were coexpressed in human embryonic kidney 293T cells. PAR4-P2Y12 dimerization was promoted by PAR4-AP and inhibited by P2Y12 antagonist. By using sequence comparison of the transmembrane domains of PAR1 and PAR4, we designed a mutant form of PAR4, "PAR4SFT," by replacing LGL194-196 at the base of transmembrane domain 4 with the corresponding aligned PAR1 residues SFT 220-222. PAR4SFT supported only 8.74% of PAR4-P2Y12 interaction, abolishing P2Y12-dependent arrestin recruitment to PAR4 and Akt activation. Nonetheless, PAR4SFT still supported homodimerization with PAR4. PAR4SFT failed to induce a calcium flux when expressed independently; however, coexpression of increasing concentrations of PAR4SFT, together with PAR4 potentiated PAR4-mediated calcium flux, suggested that PAR4 act as homodimers to signal to Gq-coupled calcium responses. In conclusion, PAR4 LGL (194-196) governs agonist-dependent association of PAR4 with P2Y12 and contributes to Gq-coupled calcium responses. PAR4-P2Y12 association supports arrestin-mediated sustained signaling to Akt. Hence, PAR4-P2Y12 dimerization is likely to be important for the PAR4-P2Y12 dependent stabilization of platelet thrombi. PMID:24723492

  17. 开关变换器电磁干扰的混沌抑制技术研究%Chaos suppression study of EMI in switching converters

    Institute of Scientific and Technical Information of China (English)

    张玉梅; 周腾蛟; 秦宏; 曲延华

    2011-01-01

    针对工作在高频状态下的开关变换器产生的瞬态脉冲含有高频谐波从而形成电磁干扰,电磁干扰通过传导和辐射的途径传播,不但对电网造成污染,而且直接影响到周围其他用电电器的正常工作这一现象.提出了开关变换器电磁干扰EMI的混沌抑制技术的分析和研究,主要以DC-DC Boost变换器为研究对象,介绍了Boost变换器的电路结构及工作原理,建立了状态方程,进行Pspice模拟仿真.证明从Boost变换器中固有的混沌现象出发,在不附加任何外围电路的情况下,通过变换参考电流的方法来使开关变换器的输入电流由普通周期状态变为混沌状态,使周期信号能量集中的频率谱线变为连续平滑频谱,降低高幅值的谱线,从而降低开关变换器的电磁干扰水平.%To solve this problem that switching converter is working in a high frequency state, which can produce a transient pulse containing high frequency harmonics that can emit electromagnetic interference, while electromagnetic interference can cause pollution to the network and direct impact to other electrical appliances to work by conduction and radiation, this paper puts forward analysis and research on Chaos Suppression of EMI in switching converters. Taking boost converter for the study and introduced the circuit structure and the principle of work, established the equation of state, carried on the Pspice simulation, it is proofed that start from boost converter inherent chaos phenomena, no additional any peripheral circuit. Through the method of transform reference current to make the input current of the switch converter from cycle state into chaos state,and make the frequency spectrum of periodic signal energy concentrated into continuous smooth spectrum, and lower high amplitude spectrum line, so that reducing switch converter electromagnetic interference level.

  18. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  19. EMI Prediction of Switching Converters

    OpenAIRE

    Trinchero, Riccardo; Stievano, Igor Simone; Canavero, Flavio

    2015-01-01

    This paper addresses the simulation of the conducted electromagnetic interference produced by circuits with periodically switching elements. The proposed method allows for the computation of their steady-state responses by means of augmented linear time-invariant equivalents built from circuit inspection only, and standard tools for circuit analysis. The approach is demonstrated on a real dc-dc boost converter by comparing simulation results with real measurements

  20. New Materials for EMI Shielding

    Science.gov (United States)

    Gaier, James R.

    1999-01-01

    Graphite fibers intercalated with bromine or similar mixed halogen compounds have substantially lower resistivity than their pristine counterparts, and thus should exhibit higher shielding effectiveness against electromagnetic interference. The mechanical and thermal properties are nearly unaffected, and the shielding of high energy x-rays and gamma rays is substantially increased. Characterization of the resistivity of the composite materials is subtle, but it is clear that the composite resistivity is substantially lowered. Shielding effectiveness calculations utilizing a simple rule of mixtures model yields results that are consistent with available data on these materials.

  1. EMI protection for communication systems

    CERN Document Server

    Malaric, Kresimir

    2009-01-01

    This practical reference provides a thorough understanding of how to protect communication systems from intentional and unintentional electromagnetic interference. You learn how to overcome critical problems in both digital and analog communications. This unique resource shows you how to shield equipment from electrical and magnetic fields, design TEM and GTEM-Cell, build capacitive coupling clamps for susceptibility tests, protect electronic equipment with filters, and calculate the measurement uncertainty. You find numerous, well-illustrated examples that make challenging electromagnetics is

  2. A model for the condensation of the bacterial chromosome by the partitioning protein ParB

    Science.gov (United States)

    Broedersz, Chase; Wingreen, Ned

    2013-03-01

    The molecular machinery responsible for faithful segregation of the chromosome in bacteria such as Caulobacter crescentus and Bacillus subtilis includes the ParABS a.k.a. Spo0J/Soj partitioning system. In Caulobacter, prior to division, hundreds of ParB proteins bind to the DNA near the origin of replication, and localize to one pole of the cell. Subsequently, the ParB-DNA complex is translocated to the far pole by the binding and retraction of the ParA spindle-like apparatus. Remarkably, the localization of ParB proteins to specific regions of the chromosome appears to be controlled by only a few centromeric parS binding sites. Although lateral interactions between DNA-bound ParB are likely to be important for their localization, the long-range order of ParB domains on the chromosome appears to be inconsistent with a picture in which protein-protein interactions are limited to neighboring DNA-bound proteins. We developed a coarse-grained Brownian dynamics model that allows for lateral and 3D protein-protein interactions among bound ParB proteins. Our model shows how such interactions can condense and organize the DNA spatially, and can control the localization and the long-range order of the DNA-bound proteins.

  3. Décontamination nucléaire par laser UV

    Science.gov (United States)

    Delaporte, Ph.; Gastaud, M.; Marine, W.; Sentis, M.; Uteza, O.; Thouvenot, P.; Alcaraz, J. L.; Le Samedy, J. M.; Blin, D.

    2003-06-01

    Le développement et l'utilisation de procédés propres pour le nettoyage ou la préparation de surfaces est l'une des priorités du milieu industriel. Cet intérêt est d'autant plus grand dans le domaine du nucléaire pour lequel la réduction des déchets est un axe de recherche important. Un dispositif de décontamination nucléaire par laser UV impulsionnel a été développé et testé. Il est composé. d'un laser à excimères de 1kW, d'un faisceau de fibres optiques et d'un dispositif de récupération des particules. Les essais réalisés en milieu actif ont démontré sa capacité à nettoyer des surfaces métalliques polluées par différents radioéléments avec des facteurs de décontamination généralement supérieurs à 10. Ce dispositif permet de décontaminer de grandes surfaces de géométrie simple en réduisant fortement la génération de déchets secondaires. Il est, à ce jour et dans ces conditions d'utilisations, le procédé de décontamination par voie sèche le plus efficace.

  4. Monitoreo de parásitos en efluentes domiciliarios

    OpenAIRE

    Liliana Semenas; Norma Brugni; Gustavo Viozzi; Ana Kreiter

    1999-01-01

    OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente ...

  5. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  6. INCORPORATION DU PHOSPHORE DANS CdTe PAR RECUIT LASER

    OpenAIRE

    Uzan, C.; Legros, R.; Marfaing, Y.

    1983-01-01

    La méthode du recuit laser a été utilisée pour incorporer du phosphore dans CdTe à partir d'une couche de Cd3P2 déposée en surface. La caractérisation par photoluminescence et mesure de profil à l'analyseur ionique montre le caractère actif du phosphore introduit et permet d'évaluer à 1018cm-3 la concentration atteinte à 1 µm de profondeur.

  7. Alex: incluir la parálisis cerebral

    OpenAIRE

    Ayuela Fernández, Mª del Mar

    2013-01-01

    El presente trabajo se basa en un estudio de caso: Alex. Un niño con una parálisis cerebral tipo espástico y su inclusión, bajo el proceso de enseñanza-aprendizaje durante el curso 2012-2013 en dos escenarios: familia y colegio. En un primer momento señalaremos los objetivos planteados a raíz de los interrogantes que nos suscita el trabajar con niños y niñas con necesidades educativas especiales. Posteriormente y tras un encuadre teórico y metodológico, abordaremos una propuesta de intervenci...

  8. Videojuego adaptado para personas con parálisis cerebral

    OpenAIRE

    Gómez Davó, Roberto

    2014-01-01

    La parálisis cerebral describe un grupo de trastornos del desarrollo psicomotor, que causan una limitación de la actividad de la persona, es decir, es un padecimiento que principalmente se caracteriza por la inhabilidad de poder controlar completamente las funciones del sistema motor. Esto puede incluir espasmos o rigidez en los músculos, movimientos involuntarios, y/o trastornos en la postura o movilidad del cuerpo. Estos trastornos psicomotores imposibilitan su interacción con los sistemas ...

  9. INNOVATIONS ET GOUVERNANCE TERRITORIALE : UNE ANALYSE PAR LES DISPOSITIFS

    OpenAIRE

    Soulard, Christophe-Toussaint; Mathé, Syndhia; Michel, Laura; Nougaredes, Brigitte; Jarrige, Françoise; Maurel, Pierre; Clement, Camille; Martinand, Pierre; Guiheneuf, Pierre-Yves; Barbe, Eric

    2010-01-01

    Cette communication vise à présenter les outils méthodologiques d’analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s’agit d’étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dans un contexte de recomposi...

  10. Innovation et gouvernance territoriale : une analyse par les dispositifs

    OpenAIRE

    Rey Valette, H.; Chia, E; Soulard, C.; Mathé, S.; Michel, L.; Nougaredes, B.; Jarrige, F.; Maurel, P.; Clement, C.; Martinand, P.; Guiheneuf, P.Y.; Barbe, E.

    2010-01-01

    International audience Cette communication vise à présenter les outils méthodologiques d'analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s'agit d'étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dan...

  11. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  12. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  13. Localization of the ParC protein in Escherichia coli cells

    OpenAIRE

    2007-01-01

    The Escherichia coli ParC protein is one of two subunits of the topoisomerase IV, a type II topoisomerase. Topo IV is responsible for relaxing positive supercoils and decatenating linked daughter chromosomes after replication. This is done by introducing transient double-stranded breaks into the DNA, passing through a segment of uncut duplex DNA, before resealing the break. Mutations in parC lead to the par phenotype which is characterized by chromosomes that can replicate but are deficient i...

  14. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  15. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  16. Condensation and localization of the partitioning protein ParB on the bacterial chromosome

    OpenAIRE

    Broedersz, Chase P.; Wang, Xindan; Meir, Yigal; Loparo, Joseph J.; Rudner, David Z.; Wingreen, Ned S.

    2014-01-01

    The ParABS system is responsible for chromosome and plasmid segregation in many bacteria. A large, coherent ParB–DNA complex forms the partitioning module at the heart of this segregation machinery. Here we provide a simple theoretical model for interacting proteins on DNA to elucidate the structure of the ParB–DNA complex. We show that that both 3D bridging and 1D spreading interactions between DNA-bound ParB proteins are required to ensure the formation of a coherent protein–DNA complex. Th...

  17. Structural and genetic analyses of a par locus that regulates plasmid partition in Bacillus subtilis.

    OpenAIRE

    Chang, S.; Chang, S Y; Gray, O

    1987-01-01

    The Bacillus plasmid pLS11 partitions faithfully during cell division. Using a partition-deficient plasmid vector, we randomly cloned DNA fragments of plasmid pLS11 and identified the locus that regulates plasmid partition (par) by cis complementation in Bacillus subtilis. The cloned par gene conferred upon the vector plasmid a high degree of segregational stability. The par locus was mapped to a 167-base-pair segment on pLS11, and its nucleotide sequence was determined. The cloned par fragme...

  18. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... equation revealed, that in all preparations IGF-II was bound to one high-affinity binding site and other sites with lower affinities. The specificity of the high-affinity 125I-IGF-II binding to the membrane vesicles assessed by displacement by unlabeled IGF-II, IGF-I and insulin showed that IGF-I displaced...... 125I-IGF-II in the range 22.5-47.9 nM (IC50) whereas insulin did not effect 125I-IGF-II binding at all. beta-Galactosidase inhibited the 125I-IGF-II binding with half-maximal inhibition of 20-30 nM beta-galactosidase. D-Mannose 6-phosphate increased the binding of 125I-IGF-II and reversed...

  19. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

    Science.gov (United States)

    Edelstein, Leonard C.; Simon, Lukas M.; Lindsay, Cory R.; Kong, Xianguo; Teruel-Montoya, Raúl; Tourdot, Benjamin E.; Chen, Edward S.; Ma, Lin; Coughlin, Shaun; Nieman, Marvin; Holinstat, Michael; Shaw, Chad A.

    2014-01-01

    Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14% more PAR4 protein than those from whites (n = 84), but this difference is not associated with platelet PAR4 function. Quantitative trait locus analysis identified 3 common single nucleotide polymorphisms in the PAR4 gene (F2RL3) associated with PAR4-induced platelet aggregation. Among these single nucleotide polymorphisms, rs773902 determines whether residue 120 in transmembrane domain 2 is an alanine (Ala) or threonine (Thr). Compared with the Ala120 variant, Thr120 was more common in black subjects than in white subjects (63% vs 19%), was associated with higher PAR4-induced human platelet aggregation and Ca2+ flux, and generated greater inositol 1,4,5-triphosphate in transfected cells. A second, less frequent F2RL3 variant, Phe296Val, was only observed in blacks and abolished the enhanced PAR4-induced platelet aggregation and 1,4,5-triphosphate generation associated with PAR4-Thr120. PAR4 genotype did not affect vorapaxar inhibition of platelet PAR1 function, but a strong pharmacogenetic effect was observed with the PAR4-specific antagonist YD-3 [1-benzyl-3(ethoxycarbonylphenyl)-indazole]. These findings may have an important pharmacogenetic effect on the development of new PAR antagonists. PMID:25293779

  20. EMI radiation testing and analysis of high-capacity solid state reorder on spacecraft%星载大容量固态存储器EMI辐射测试与分析

    Institute of Scientific and Technical Information of China (English)

    葛欣宏; 宁飞; 贺庚贤; 李晓林

    2015-01-01

    Based on EMI radiation test results of high-capacity solid state reorder on the spacecraft , its electromagnet-ic not compatible status is analyzed and corrected.High-capacity solid state reorder on the spacecraft needs to meet electromagnetic radiation requirements, such as RE102.In the electromagnetic compatibility standard test, RE102 is seriously overweight.Firstly, combined with high-capacity solid state reorder’s works, based on the theory of electro-magnetic shielding and electromagnetic radiation theory, the test results of the RE102 is analyzed.Secondly, the main reason for the overweight of electromagnetic radiation in interconnect cables is confirmed .And the excitation ra-diation source to generate electromagnetic is further analyzed.Finally, the rectification plan is accordingly proposed. The results show that, after using EMC shielding and filtering measures, EMI emission attenuation is greater than 30dB, high-capacity solid state reorder’s EMI radiation test results meet the technical requirements of RE102.%基于星载大容量固态存储器的EMI辐射测试结果,对其电磁不兼容状态进行了EMC分析与整改。依据GJB151A-1997,星载大容量固态存储器需要满足RE102电场辐射要求,为了使RE102超标严重的星载大容量固态存储器满足标准要求,首先,结合星载大容量固态存储器的工作原理,依据电磁屏蔽理论及电磁辐射理论,对RE102的测试结果进行了分析。其次,确定了辐射超标的主要原因为互连线缆的电磁辐射,并进一步分析了电磁辐射的激励源产生方式。最后,依据分析结果提出了相应的整改方案并进行了整改。结果表明,采用EMC屏蔽和滤波措施后,EMI发射衰减大于30 dB,星载大容量固态存储器的EMI辐射测试结果满足RE102技术指标要求。

  1. Key optimization of light source parameters of lidar system for bioaerosol detection%生物气溶胶激光遥测系统光源关键参数优化

    Institute of Scientific and Technical Information of China (English)

    杨子健; 陈锋; 李抄; 余明; 吴太虎

    2015-01-01

    Objective There are three categories of bioaerosol laser telemetry systems according to the light source configuration parameters:namely traditional lidar(light datection and ranging,laser radar), micro-pulse lidar and pseudo-random modulation(lidar).The system source parameters,which impact the degree of danger and detection sensitivity of the system, need to be optimized.Methods With reference to the USA laser product safety standards and by establishing the corresponding mathematical model of a lidar, the three categories of lidar source configuration were compared according to signal to noise ratio(SNR) and security before the repetition rate, pulse energy, divergence angle, distance and other dangerous impact factors were calculated.Results The results showed that to ensure eyesafety, the use of the pulse frequency should be set at 55 kHz for the highest SNR under the micro-pulse lidar excitation mode.Conclusion The eyesafety requirements impact the excitation of light source of a bioaerosol telemetry system.%目的:生物气溶胶激光遥测系统按光源配置参数主要分为3类,即传统激光雷达、微脉冲激光雷达、伪随机调制激光雷达。其系统光源参数严重影响系统的危险性和探测灵敏度,需要进行优化计算。方法参考美国关于激光产品使用的安全标准,并建立对应的激光雷达的数学模型,对比3种激光雷达光源配置方式的信噪比( SNR)和安全性,计算重复频率、脉冲能量、发散角、危险距离等因素的影响。结果计算结果表明,在保证人眼安全的前提下,使用微脉冲雷达的光源激发方式,脉冲频率设置约为55 kHz时系统探测的SNR最高。结论人眼安全是前提,对于激光遥测系统的光源激发方式影响较大,该文计算出最优的光源配置方法,阐明了较为安全的应用方式。

  2. Pierre Vilar Frontinhan 1906 - París 2003

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez

    2010-08-01

    Full Text Available En el pasado mes de agosto falleció en París el historiador y maestro de tantas generaciones Pierre Vilar. Aunque había mantenido una intensa actividad de reflexión sobre los sucesos contemporáneos, ésta se vio afectada en 1991 luego que una grave enfermedad le negó la visión. Fue entonces cuando decidió con la ayuda de Rosa Congost escribir sus reflexiones y recuerdos, especie de memoria de juventud. Pensar Históricamente (Barcelona: Editorial Crítica, 1997, el libro que reúne estos ejercicios, es una obra de sumo interés para conocer la infancia, adolescencia y juventud de este connotado historiador.

  3. Usinage des Composites par Jet d'eau Abrasif

    OpenAIRE

    Cénac, François; Collombet, Francis; Zitoune, Rédouane; Déléris, Michel

    2011-01-01

    International audience; Le protocole expérimental de fraisage par jet d'eau abrasif obtenu sur aluminium est adapté aux matériaux composites. On met en exergue deux différences majeures liées à l'effet du JEA entre les composites et l'aluminium que sont l'usinabilité et les variabilités. L'usinabilité des matériaux composites étant plus grande que celle de l'aluminium pour le JEA, on propose des plages de paramètres différentes pour les composites, du fait des limitations des machines standar...

  4. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  5. Hemangioma capilar de la parótida. Abordaje transoral

    Directory of Open Access Journals (Sweden)

    Luis Domingo Sarra

    2014-10-01

    Presentamos un caso en una paciente adulta que consultó por una masa en la región parotídea y parálisis facial periférica con el mayor componente tumoral que se manifestaba en la cavidad oral. La ecografía mostró una masa sólida. La punción aspiración con aguja fina fue negativa con material hemático en 2 oportunidades. No tuvimos sospecha de la presencia de un tumor de origen vascular, por lo que no fue solicitada una RMN. El caso fue resuelto a través de un abordaje quirúrgico poco utilizado, tras obtener una biopsia por congelación negativa.

  6. Simulation numérique du soudage par frottement malaxage

    OpenAIRE

    Guerdoux, Simon

    2007-01-01

    Ce travail présente le développement d'un outil numérique. Une formulation arbitrairement lagrangienne-eulérienne (ALE) est implémentée dans le logiciel 3D éléments finis FORGE3® pour simuler les différentes étapes du procédé de soudage par frottement malaxage (FSW). Une méthode découplée est utilisée : a) les champs de vitesses, pressions et températures du matériau sont calculés, b) la vitesse de maillage est calculée à partir de l'évolution des frontières du domaine et d'un critère de raff...

  7. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  8. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  9. Research on Rejection of Transformer Shield to Common-Mode Conducted EMI in Switching Mode Power Supply%开关电源变压器屏蔽层抑制共模EMI的研究

    Institute of Scientific and Technical Information of China (English)

    王亮

    2010-01-01

    以反激式开关电源为例,在分析其高频变压器形成共模传导EMI机理的基础上,探讨了在变压器设计中设置屏蔽层以抑制共模传导EMI的原理.给出了具体的设计方法,并应用于具体产品的设计中.试验测试表明,屏蔽层的设置可以有效地抑制高频开关电源的共模传导EMI.由此进一步研究了屏蔽层在其他类型开关电源中应用的可行性.

  10. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. PMID:26310455

  11. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W;

    2011-01-01

    are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after......The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections......PAR levels as compared to patients with no deep infection focus. suPAR was found to be prognostic for mortality in receiver operator characteristic (ROC) curve analysis, which was not observed for serum C-reactive protein (CRP); the area under the curve (AUC) for suPAR was 0.754 (95% confidence interval [CI...

  12. 12 CFR 925.19 - Par value and price of stock.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Par value and price of stock. 925.19 Section 925.19 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES MEMBERS OF THE BANKS Stock Requirements § 925.19 Par value and price of stock. The capital...

  13. Effect of pre-drying and par-frying conditions on the crispness of French fries

    NARCIS (Netherlands)

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all sampl

  14. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjærgaard, Magnus; Hansen, Line; Jacobsen, Benedikte;

    2008-01-01

    on disulfide connectivities, and they adopt a characteristic three-finger fold. Interestingly, the gene for uPAR is localized in a cluster of 6 homologous genes encoding proteins with multiple LU-domains. The structural biology of uPAR will be reviewed with special emphasis on its multidomain composition...

  15. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  16. Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    DEFF Research Database (Denmark)

    Hansen, Line; Larsen, Esben Kjær Unmack; Nielsen, Erik Holm;

    2013-01-01

    patient prognosis shared by several cancers including breast, colorectal, and gastric cancers. Conjugation of a uPAR specific targeting peptide onto polyethylene glycol (PEG) coated USPIO nanoparticles by click chemistry resulted in a five times higher uptake in vitro in a uPAR positive cell line compared...

  17. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability.

    Science.gov (United States)

    Kimura, Tetsuya; Sakai, Toshinori; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-06-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  18. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  19. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  20. Study of High-Resolution Spectroscopy of Plutonium. Part I. Contribution to the Classification of the Arc Spectrum. Part II. Determination of the Magnetic Moment of {sup 239}Pu; Etude du plutonium par spectroscopie a haute resolution: contribution a la classification du spectre d'arc et determination du moment magnetique de {sup 239}Pu

    Energy Technology Data Exchange (ETDEWEB)

    Gerstenkorn, S

    1962-07-01

    The study of the hyperfine structure and isotope shift enabled the positions of the first five levels of the multiplet {sup 7}F{sub 0-6} belonging to the fundamental configuration 5f{sup 6}7s{sup 2} to be determined. The classification of the arc spectrum begun in this way led to 25 odd levels, the number of classified lines (70) representing about 30 p. 100 of the light emitted by this hollow cathode in the visible. In addition, the isotope shifts of many lines and the data given by the King furnace show that the first levels of the configuration 5f{sup 5}6d7s{sup 2} are also low less than 8000 cm{sup -1} above the fundamental level {sup 7}F{sub 0}. The proximity of the configuration f{sup 6}s{sup 2} and f{sup 5}ds{sup 2} shows that the bonding energies of the 5f and 6d electrons are of the same order of magnitude and this fact must be responsible for the multiple valences belonging to plutonium. From the hyperfine structure of spark lines (Pu II) the interval factor a{sub 7} for the electron was deduced giving for the calculated nuclear moment of {sup 239}Pu a value of +0.21 {+-}0.06 {mu}{sub N}. The position of the hyperfine components show that the nuclear moment is positive, although the theoretical value given by B. R. Mottelson and S. Nillson is negative and equal to -0.1 {mu}{sub N}. (author) [French] Partie 1 - L'etude des structures hyperfines et du deplacement isotopique des raies du spectre d'arc du plutonium a permis de determiner la position des cinq premiers niveaux du multiplet {sup 7}F{sub 0-6} correspondant a la configuration fondamentale 5f{sup 6}7s{sup 2}. Des lors, la classification du spectre d'arc du plutonium pouvait etre amorcee: 25 niveaux impairs ont ete mis en evidence et le nombre de raies classees (70) represente environ 30 p. 100 de l'intensite totale du spectre d'arc emis par une cathode creuse dans le visible. D'autre part, le deplacement isotopique de certaines raies, joint aux renseignements donnes

  1. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  2. CERCLA interim action at the Par Pond unit: A case study

    International Nuclear Information System (INIS)

    The Par Pond unit designated under CERCLA consists of sediments within a Savannah River Site (SRS) cooling water reservoir. The sediments are contaminated with radionuclides and nonradioactive constituents from nuclear production reactor operations. The mercury in Par Pond is believed to have originated from the Savannah River. Because of Par Pond Dam safety Issues, the water level of the reservoir was drawn down, exposing more than 1300 acres of contaminated sediments and triggering the need for CERCLA interim remedial action. This paper presents the interim action approach taken with Par Pond as a case study. The approach considered the complexity of the Par Pond ecosystem, the large size of Par Pond, the volume of contaminated sediments, and the institutional controls existing at SRS. The Environmental Protection Agency (EPA) considers units with large volumes of low-concentration wastes, as is the case with Par Pond, to be open-quotes special sites.close quotes Accordingly, EPA guidance establishes that the range of alternatives developed focus primarily on containment options and other remedial approaches that mitigate potential risks associated with the open-quotes special site.close quotes The remedial alternatives, according to EPA, are not to be prohibitively expensive or difficult to implement. This case study also is representative of the types of issues that will need to be addressed within the Department of Energy (DOE) complex as nuclear facilities are transitioned to inactive status and corrective/remedial actions are warranted

  3. Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity

    Directory of Open Access Journals (Sweden)

    Wu QiNan

    2016-01-01

    Full Text Available Apoptosis of islet β cells is a primary pathogenic feature of type 2 diabetes, and ER stress and mitochondrial dysfunction play important roles in this process. Previous research has shown that prostate apoptosis response-4 (Par-4/NF-κB induces cancer cell apoptosis through endoplasmic reticulum (ER stress and mitochondrial dysfunction. However, the mechanism by which Par-4/NF-κB induces islet β cell apoptosis remains unknown. We used a high glucose/palmitate intervention to mimic type 2 diabetes in vitro. We demonstrated that the high glucose/palmitate intervention induced the expression and secretion of Par-4. It also causes increased expression and activation of NF-κB, which induced NIT-1 cell apoptosis and dysfunction. Overexpression of Par-4 potentiates these effects, whereas downregulation of Par-4 attenuates them. Inhibition of NF-κB inhibited the Par-4-induced apoptosis. Furthermore, these effects occurred through the ER stress cell membrane and mitochondrial pathway of apoptosis. Our findings reveal a novel role for Par-4/NF-κB in islet β cell apoptosis and type 2 diabetes.

  4. Identification of uPAR-positive chemoresistant cells in small cell lung cancer.

    Directory of Open Access Journals (Sweden)

    Margarita Gutova

    Full Text Available BACKGROUND: The urokinase plasminogen activator (uPA and its receptor (uPAR/CD87 are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most invasive cancer phenotypes and is a strong predictor of poor patient survival. However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC, the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype. METHODS AND FINDINGS: We screened six human SCLC cell lines for surface markers for putative stem and cancer cells. We used fluorescence-activated cell sorting (FACS, fluorescence microscopy and clonogenic assays to demonstrate uPAR expression in a subpopulation of cells derived from primary and metastatic SCLC cell lines. Cytotoxic assays were used to determine the sensitivity of uPAR-positive and uPAR-negative cells to chemotherapeutic agents. The uPAR-positive cells in all SCLC lines demonstrated multi-drug resistance, high clonogenic activity and co-expression of CD44 and MDR1, putative cancer stem cell markers. CONCLUSIONS: These data suggest that uPAR-positive cells may define a functionally important population of cancer cells in SCLC, which are resistant to traditional chemotherapies, and could serve as critical targets for more effective therapeutic interventions in SCLC.

  5. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  6. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  7. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation.

    Directory of Open Access Journals (Sweden)

    Hem C Jha

    2016-07-01

    Full Text Available Studies have suggested that Epithelial-Mesenchymal Transition (EMT and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA encoded by Kaposi's Sarcoma associated herpesvirus (KSHV regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas.

  8. The urokinase receptor (uPAR facilitates clearance of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Joppe W R Hovius

    2009-05-01

    Full Text Available The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR; however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity and PAI-1 (high fibrinolytic activity knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1beta mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system.

  9. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation

    Science.gov (United States)

    Jha, Hem C.; Sun, Zhiguo; Upadhyay, Santosh K.; El-Naccache, Darine W.; Singh, Rajnish K.; Sahu, Sushil K.; Robertson, Erle S.

    2016-01-01

    Studies have suggested that Epithelial–Mesenchymal Transition (EMT) and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA) encoded by Kaposi's Sarcoma associated herpesvirus (KSHV) regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition) during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas. PMID:27463802

  10. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  11. Triamcinolone-assisted Pars Plana Vitrectomy for Retinal Disease

    Institute of Scientific and Technical Information of China (English)

    Yuping Zheng; Naixue Sun; Quanchen Xiong; Xiaohua Wang; Yanlong Quan

    2005-01-01

    Purpose:To determine whether triamcinolone acetonide (TA)staining facilitates posterior hyaloid removal in patients undergoing pars plana vitrectomy (PPV) for retinal disease.Methods: A triamcinolone acetonide(TA)-assisted vitrectomy was performed on patients with the following disease: proliferative diabetic retionpathy(5eyes), central retinal vein occlusion(5eyes), macuar hole (3eyes), and epiretinal membrane(2eyes). Eyes without apparent preoperative posterior vitreous detachment were enrolled in this study. After a core PPV, TA aqueous suspension (40 mg/ml) was injected into the mid vitreous cavity to visualize the posterior hyaloid, thus allowing a complete posterior hyaloid separation and removal. The visual acuity, intraocular pressure (IOP), tamponade, corneal pathology, after-cataract, vitreous hemorrhage, and necessity for reoperation were thereafter examined for at least 3 months after surgery.Results: In all patients, the vitreous body was clearly seen by means of triamcinolone during surgery, and complete removal of posterior hyaloid was facilitated and confirmed.Retina was attached in 14 of 15 eyes, and vision acuity was improved in 9 of 15 eyes.Two eyes showed transient postoperative IOP elevation, 2 eyes had after cataract formation and 1eye had cataract progression. Vitreous hemorrhage occurred in 1 eye. No eye had corneal pathology.Conclusion: Triamcinolone improved the visibility of the hyaloid and the safety of surgical procedures during PPV. No obvious adverse effect due to toxicity of TA accrued in TA-assisted PPV.

  12. Phacoemulsification and pars plana vitrectomy: A combined procedure

    Directory of Open Access Journals (Sweden)

    Jain Vandana

    2007-01-01

    Full Text Available Aim: To describe the results of a combined procedure including phacoemulsification, insertion of posterior chamber intraocular lens (PCIOL and pars plana vitrectomy (PPV in eyes with vitreoretinal pathology and coexisting significant cataract. Design: Retrospective, consecutive, noncomparative, interventional case series. Materials and Methods: Medical records of patients who had undergone phacoemulsification, PPV and PCIOL implantation as a combined procedure between January 2000 and December 2004 were retrospectively reviewed. The main outcome measures were the anatomical success of retina, defined as reattached retina, intraoperative and postoperative complications and functional success in terms of final best corrected visual acuity. Results: In all, 65 eyes of 64 patients were included. The mean age of the patients was 50.9 years ± 17.1 (range, five to 82 years. Vitreous hemorrhage with or without retinal detachment (19 eyes, 29.2% was the most common indication for the vitreoretinal procedure. Primary anatomical success of retina was achieved in 59 eyes (90.7%. Visual acuity improved in 48 eyes (73.8%, was unchanged in 12 eyes (18.5% and deteriorated in five eyes (7.7%. Postoperative inflammation was significantly more in the subgroup of previously vitrectomized eyes (42% ( P =0.014, Fisher exact test compared to those which underwent primary vitrectomy. Conclusions: Combined surgery is a feasible option for patients with vitreoretinal diseases and cataract.

  13. Epidémie de la mort par surmenage ?

    Institute of Scientific and Technical Information of China (English)

    孔冰逸

    2011-01-01

    Ces derniers jours,on parle beaucoup de la mort par surmenage.Une série de disparitions de personnes travaillant dans le domaine de la communication fait réfléchir beaucoup de gens sur leur état de santé et sur la pression au travail.Est-ce une épidémie ? On·commence à s'en inquiéter,car on pense que ces décès sont dus au surmenage.Le 23 mai,Liu Jianfa,un jeune homme de 28 ans,a succombé à un infarctus aigu du myocarde.En tant que té1éporter de la cha(i)ne des sciences politiques et juridiques de la Té1évision de Zhengzhou,il travaillait beaucoup.Le temps d'un repos suffisant était comme mission impossible.Une semaine avant sa mort,il a écrit dans son micro-blog:《 Mon état de santé est grave.》 Mais son message suivant concerne encore le travail:《 Où va-t-on demain pour finir les t(a)ches ? 》

  14. Los parásitos de los animales domésticos.

    OpenAIRE

    Cruz B. Luis

    2012-01-01

    Desde el año 1937, el Departamento Nacional de Agricultura, desean prestar un servicio más efectivo para el agricultor costarricense, viene publicando en su Revista Agrícola, artículos referentes a los parásitos que infestan nuestro ganados e incluyendo siempre las medidas más prácticas para su control. Durante muchos años, los parásitos de los animales han constituido un verdadero flagelo para la industria costarricense, entorpeciendo su progreso; pero desde que el Servicio de Par...

  15. Pars plana cicatrization of sewn-in posterior chamber intraocular lens haptics.

    Science.gov (United States)

    McDermott, M L; Puklin, J E

    1997-03-01

    The authors describe the unexpected finding of cicatrization of posterior chamber lens haptics to the pars plana. This was found during removal of a secondary, transscleral sewn-in pseudophakos during a retinal reattachment procedure. Ophthalmic history and intraoperative photography revealed pars plana cicatrization of haptics. Despite removal of trans-scleral prolene fixation sutures and application of gentle traction, the posterior chamber lens haptics remained firmly adherent to pars plana retina. The haptics were amputated to prevent significant chorioretinal damage. The conventional belief that all sewn-in posterior chamber intraocular lenses cause little or no scarring response around the haptics may be unfounded.

  16. Effect of pre-drying and par-frying conditions on the crispness of French fries

    OpenAIRE

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all samples. Crispness was evaluated with a sensory panel. Furthermore, samples were analysed with a texture analyser and with confocal scanning laser microscopy (CSLM). Par-frying at 180 °C resulted in a c...

  17. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  18. Sécurité et immigration : vers une gouvernementalité par linquiétude ?

    OpenAIRE

    Bigo, Didier

    2006-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  19. Downregulation of uPAR and Cathepsin B Retards Cofilin Dephosphorylation

    OpenAIRE

    Christopher S Gondi; Kandhukuri, Neelima; Kondraganti, Shakuntala; Gujrati, Meena; Olivero, William C.; Dinh, Dzung H.; Rao, Jasti S.

    2006-01-01

    Cathepsin B and uPAR play key roles in cancer cell migration and invasion. Here, we demonstrate that the simultaneous, siRNA-mediated downregulation of uPAR and cathepsin B inhibits glioma cell migration and is accompanied by cytoskeletal condensation. We show that the dephosphorylation of cofilin is inhibited by the downregulation of uPAR alone and, to a lesser extent, by the downregulation of cathepsin B alone, and that the effect was much higher by the downregulation of both molecules by p...

  20. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  1. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; ORTEU, Jean-José

    2009-01-01

    Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données 3D acquises en chaque...

  2. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; Orteu, Jean-José

    2009-01-01

    National audience Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données ...

  3. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian;

    2010-01-01

    -suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U......-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  4. Average of peak-to-average ratio (PAR) of IS95 and CDMA2000 systems-single carrier

    OpenAIRE

    Lau, VKN

    2001-01-01

    Peak-to-average ratio (PAR) of a signal is an important parameter. It determines the input backoff factor of the amplifier to avoid clipping and spectral regrowth. We analyze and compose the PAR of the downlink signal for IS95 and the CDMA2000 single-carrier systems. It is found that the PAR of the transmitted signal depends on the Walsh code assignment. Furthermore, we found that the PAR of CDMA2000 signal is always lower than the IS95 signal. Finally, PAR control by Walsh code selection is ...

  5. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2.

    OpenAIRE

    Easter, C L; Sobecky, P A; Helinski, D. R.

    1997-01-01

    A 3.2-kb region of the broad-host-range plasmid RK2 has been shown to encode a highly efficient plasmid maintenance system that functions in a vector-independent manner. This region, designated par, consists of two divergently arranged operons: parCBA and parDE. The 0.7-kb parDE operon promotes plasmid stability by a postsegregational killing mechanism that ensures that plasmid-free daughter cells do not survive after cell division. The 2.3-kb parCBA operon encodes a site-specific resolvase p...

  6. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of abou...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....

  7. Controle social em saúde: o caso do Pará Social control in health: Pará's case

    OpenAIRE

    Solange Conceição Albuquerque de Cristo

    2012-01-01

    Este artigo objetiva contribuir para um exame mais circunstanciado das experiências de controle social. De acordo com o Cadastro dos Conselhos Municipais de Saúde no Brasil (2006), quase um terço da presidência dos Conselhos de Saúde no Pará é ocupada por representantes do segmento dos usuários. As análises desenvolvidas, a partir de entrevistas realizadas com presidentes de dois conselhos no Pará, permitiram compreender os desafios que os Conselhos de Saúde vêm enfrentando para participar da...

  8. Two new biting midges from Pará, Brazil (Diptera: Ceratopogonidae

    Directory of Open Access Journals (Sweden)

    Rosimeire Lopes da Trindade

    2011-02-01

    Full Text Available Two new species of Culicoides Latreille of the subgenus Haematomyidium Goeldi are described and illustrated based on female specimens from Pará, Brazil. The new species are compared with their similar congeners.

  9. PAR-Aware Large-Scale Multi-User MIMO-OFDM Downlink

    CERN Document Server

    Studer, Christoph

    2012-01-01

    We investigate an orthogonal frequency-division multiplexing (OFDM)-based downlink transmission scheme for large-scale multi-user (MU) multiple-input multiple-output (MIMO) wireless systems. The use of OFDM causes a high peak-to-average (power) ratio (PAR), which necessitates expensive and power-inefficient radio-frequency (RF) components at the base station. In this paper, we present a novel downlink transmission scheme, which exploits the massive degrees-of-freedom available in large-scale MU-MIMO-OFDM systems to achieve low PAR. Specifically, we propose to jointly perform MU precoding, OFDM modulation, and PAR reduction by solving a convex optimization problem. We develop a corresponding fast iterative truncation algorithm (FITRA) and show numerical results to demonstrate tremendous PAR-reduction capabilities. The significantly reduced linearity requirements eventually enable the use of low-cost RF components for the large-scale MU-MIMO-OFDM downlink.

  10. ANALYSES EXPERIMENTALES ET NUMERIQUES DU PROCEDE DE SOUDAGE PAR FRICTION MALAXAGE FSW

    OpenAIRE

    Lorrain, Olivier

    2010-01-01

    Le soudage par friction malaxage FSW est un procédé de soudage à l'état solide, sans fusion du matériau. La soudure est réalisée par l'action d'un outil composé d'un épaulement et d'un pion positionné à l'interface des deux pièces à souder. L'outil a deux rôles : échauffement de la matière par frottement de l'épaulement, malaxage de la matière par l'intermédiaire du pion. Ce travail de thèse s'inscrit dans le cadre d'un partenariat entre Arts et Métiers ParisTech et l'Institut de Soudure. Son...

  11. Inmunidad frente a infecciones: bacterias, virus, hongos y parásitos

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Respuesta inmune frente a la infección: Bacterias extracelulares, bacterias intracelulares, hongos, virus, parásitos. Inmunidad innata, inmunidad adaptativa, mecanismos de evasión, consecuencias perjudiciales de la respuesta inmune.

  12. 25-Gauge pars plana vitrectomy for ciliary block (malignant) glaucoma.

    Science.gov (United States)

    Meng, Li; Wei, Wenbin; Li, Yanlong; Hui, Xiaoying; Han, Xiaodong; Shi, Xiaobo

    2015-08-01

    To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PPV for alleviating this disease. All phakic eyes underwent phacoemulsification surgery during vitrectomy. Control of intraocular pressure (IOP), pre- and postoperative best-corrected visual acuity (BCVA), and development of intra- and postoperative complications were evaluated during follow-up. Malignant glaucoma was promptly resolved, and recurrence was not observed during a mean follow-up period of 12.7 ± 3.2 (range 6-18) months. The mean IOP decreased from 35.9 ± 2.9 mmHg, preoperatively, to 16.0 ± 1.4 mmHg, measured at last visit (P = 0.013). Although IOP control was achieved in all eyes after surgery, two eyes required long-term topical antiglaucoma medication. The mean logarithm of the minimum angle of resolution BCVA improved from +0.69 ± 0.11, preoperatively, to +0.29 ± 0.07, postoperatively (P = 0.027). No severe intraoperative complications were observed. Postoperative complications mostly occurred during the first week after surgery, including transient corneal edema and Descemet's membrane folds in three eyes, fibrotic exudation in 2, local iris posterior synechia in 1, and transient hypotony in 1, which were resolved spontaneously or with medication. The 25-ga PPV procedure seems to be safe and effective for treating malignant glaucoma. Combined vitrectomy with phacoemulsification surgery and a staged surgical approach may improve the success rate. PMID:25062710

  13. Unitary synaptic connections among substantia nigra pars reticulata neurons.

    Science.gov (United States)

    Higgs, Matthew H; Wilson, Charles J

    2016-06-01

    Neurons in substantia nigra pars reticulata (SNr) are synaptically coupled by local axon collaterals, providing a potential mechanism for local signal processing. Because SNr neurons fire spontaneously, these synapses are constantly active. To investigate their properties, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from SNr neurons in brain slices, in which afferents from upstream nuclei are severed, and the cells fire rhythmically. The sIPSC trains contained a mixture of periodic and aperiodic events. Autocorrelation analysis of sIPSC trains showed that a majority of cells had one to four active unitary inputs. The properties of the unitary IPSCs (uIPSCs) were analyzed for cells with one unitary input, using a model of periodic presynaptic firing and stochastic synaptic transmission. The inferred presynaptic firing rates and coefficient of variation of interspike intervals (ISIs) corresponded well with direct measurements of spiking in SNr neurons. Methods were developed to estimate the success probability, amplitude distributions, and kinetics of the uIPSCs, while removing the contribution from aperiodic sIPSCs. The sIPSC amplitudes were not increased upon release from halorhodopsin silencing, suggesting that most synapses were not depressed at the spontaneous firing rate. Gramicidin perforated-patch recordings indicated that the average reversal potential of spontaneous inhibitory postsynaptic potentials was -64 mV. Because of the change in driving force across the ISI, the unitary inputs are predicted to have a larger postsynaptic impact when they arrive late in the ISI. Simulations of network activity suggest that this very sparse inhibitory coupling may act to desynchronize the activity of SNr neurons while having only a small effect on firing rate. PMID:26961101

  14. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  15. Developpement de techniques de diagnostic non intrusif par tomographie optique

    Science.gov (United States)

    Dubot, Fabien

    Que ce soit dans les domaines des procedes industriels ou de l'imagerie medicale, on a assiste ces deux dernieres decennies a un developpement croissant des techniques optiques de diagnostic. L'engouement pour ces methodes repose principalement sur le fait qu'elles sont totalement non invasives, qu'elle utilisent des sources de rayonnement non nocives pour l'homme et l'environnement et qu'elles sont relativement peu couteuses et faciles a mettre en oeuvre comparees aux autres techniques d'imagerie. Une de ces techniques est la Tomographie Optique Diffuse (TOD). Cette methode d'imagerie tridimensionnelle consiste a caracteriser les proprietes radiatives d'un Milieu Semi-Transparent (MST) a partir de mesures optiques dans le proche infrarouge obtenues a l'aide d'un ensemble de sources et detecteurs situes sur la frontiere du domaine sonde. Elle repose notamment sur un modele direct de propagation de la lumiere dans le MST, fournissant les predictions, et un algorithme de minimisation d'une fonction de cout integrant les predictions et les mesures, permettant la reconstruction des parametres d'interet. Dans ce travail, le modele direct est l'approximation diffuse de l'equation de transfert radiatif dans le regime frequentiel tandis que les parametres d'interet sont les distributions spatiales des coefficients d'absorption et de diffusion reduit. Cette these est consacree au developpement d'une methode inverse robuste pour la resolution du probleme de TOD dans le domaine frequentiel. Pour repondre a cet objectif, ce travail est structure en trois parties qui constituent les principaux axes de la these. Premierement, une comparaison des algorithmes de Gauss-Newton amorti et de Broyden- Fletcher-Goldfarb-Shanno (BFGS) est proposee dans le cas bidimensionnel. Deux methodes de regularisation sont combinees pour chacun des deux algorithmes, a savoir la reduction de la dimension de l'espace de controle basee sur le maillage et la regularisation par penalisation de Tikhonov

  16. Pars Plana Ahmed Implantation Combined with 23-gauge Vitrectomy for Refractory Neovascular Glaucoma in Diabetic Retinopathy

    OpenAIRE

    Jeong, Hoon Seok; Nam, Dong Heun; Paik, Hae Jung; Lee, Dae Yeong

    2012-01-01

    Purpose To evaluate the efficacy and safety of a pars plana Ahmed valve implantation combined with 23-gauge sutureless vitrectomy in the treatment of patients with medically uncontrolled neovascular glaucoma (NVG) in proliferative diabetic retinopathy (PDR). Methods The authors retrospectively reviewed the records of 11 consecutive patients with refractory NVG in PDR who underwent a 23-gauge sutureless vitrectomy combined with pars plana placement of an Ahmed valve implant. Control of intraoc...

  17. Transconjunctival 25-gauge pars plana vitrectomy and internal limiting membrane peeling for chronic macular edema

    OpenAIRE

    Cho M; D'Amico DJ

    2012-01-01

    Minhee Cho, Donald J D'AmicoWeill Cornell Medical College, Department of Ophthalmology, New York, NY, USABackground: The purpose of this study was to investigate the visual and anatomic outcomes in patients with chronic macular edema who underwent 25-gauge pars plana vitrectomy with internal limiting membrane peeling.Methods: This study was a retrospective chart review of 24 eyes from 21 patients who underwent 25-gauge pars plana vitrectomy and indocyanine green-assisted internal limi...

  18. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  19. Negative Regulation of Neuromedin U mRNA Expression in the Rat Pars Tuberalis by Melatonin

    OpenAIRE

    Sayaka Aizawa; Ichiro Sakata; Mai Nagasaka; Yuriko Higaki; Takafumi Sakai

    2013-01-01

    The pars tuberalis (PT) is part of the anterior pituitary gland surrounding the median eminence as a thin cell layer. The characteristics of PT differ from those of the pars distalis (PD), such as cell composition and gene expression, suggesting that the PT has a unique physiological function compared to the PD. Because the PT highly expresses melatonin receptor type 1, it is considered a mediator of seasonal and/or circadian signals of melatonin. Expression of neuromedin U (NMU) that is know...

  20. ON THE PAR REDUCTION OF MB-OFDM ULTRA-WIDEBAND SIGNALS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The Peak to Average power Ratio (PAR) of a Multi-Band Orthogonal Frequency-Division Multi-plexing (MB-OFDM) Ultra-Wide Band (UWB) signals can be substantially larger than that of single carrieror carrier-less ultra-wideband signals. In this letter, a novel PAR reduction scheme for the MB-OFDM UWBsystem based on spreading and interleaving is proposed. By spreading the coded bits over each subcarrier incorresponding band and interleaving the spread symbols across all bands, the PAR statistics of theMB-OFDM signals can be improved and the PAR is reduced obviously. In the PAR reduction scheme, there isno loss in transmission data rate or Bit Error Rate (BER) performance decreasing. Since the spreading andinterleaving operation are implemented by unitary Hadamard sequences and used for an approach to providethe robustness of the UWB system to narrowband interference, there is no additional implementation burden.Simulation results show that the investigated scheme gives the PAR reduction of 3dB compared with that ofthe original MB-OFDM signals.

  1. Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist

    DEFF Research Database (Denmark)

    Ploug, Michael

    2013-01-01

    -function relationships in uPAR has been refined to such a level that a rational design of uPAR function as well as compounds specifically targeting defined functions of uPAR are now realistic options. This knowledge opens new avenues for developing therapeutic intervention regimens targeting uPAR as well...

  2. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-03-01

    Full Text Available [Français] L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté. [English] The use of the Web presented in this article supports a teaching approach based on knowledge sharing. Within the context of an industrial simulation, the students in an advanced programming course must learn to share their expertise, to communicate their questions clearly, to describe problems, and to deal with unexpected reversals. The Web becomes a collaborative space for disseminating the requests of a fictional client, along with directives, preliminary studies, and agreements. The results obtained tend to suggest that this global approach forces the student to plan better, increases the level of cooperation, facilitates the production of analogies, and invites the students to improve how they formulate and describe their problems. A system that facilitates the logistics of peer review (retrieving assignments, constructing an evaluation chart, and disseminating results is also presented.

  3. A Dual Mechanism Controls Nuclear Localization in the Atypical Basic-Helix-Loop-Helix Protein PAR1 of Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Anahit Galstyan; Jordi Bou-Torrent; Irma Roig-Villanova; Jaime F. Martínez-García

    2012-01-01

    PAR1 is an atypical basic-helix-loop-helix (bHLH) protein that negatively regulates the shade avoidance syndrome in Arabidopsis thaliana acting as a transcriptional cofactor.Consistently with this function,PAR1 has to be in the nucleus to display biological activity.Previous structure-function analyses revealed that the N-terminal region of PAR1 drives the protein to the nucleus.However,truncated forms of PAR1 lacking this region still display biological activity,implying that PAR1 has additional mechanisms to localize into the nucleus.In this work,we compared the primary structure of PAR1 and various related and unrelated plant bHLH proteins,which led us to suggest that PAR1 contains a non-canonical nuclear localization signal (NLS) in the N-terminal region.By overexpressing truncated and mutated derivatives of PAR1,we have also investigated the importance of other regions of PAR1,such as the acidic and the extended HLH dimerization domains,for its nuclear localization.We found that,in the absence of the N-terminal region,a functional HLH domain is required for nuclear localization.Our results suggest the existence of a dual mechanism for PAR1 nuclear localization:(1) one mediated by the N-terminal non-consensus NLS and (2) a second one that involves interaction with other proteins via the dimerization domain.

  4. ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA.

    Science.gov (United States)

    Hui, Monica P; Galkin, Vitold E; Yu, Xiong; Stasiak, Alicja Z; Stasiak, Andrzej; Waldor, Matthew K; Egelman, Edward H

    2010-03-01

    Most bacterial chromosomes contain homologs of plasmid partitioning (par) loci. These loci encode ATPases called ParA that are thought to contribute to the mechanical force required for chromosome and plasmid segregation. In Vibrio cholerae, the chromosome II (chrII) par locus is essential for chrII segregation. Here, we found that purified ParA2 had ATPase activities comparable to other ParA homologs, but, unlike many other ParA homologs, did not form high molecular weight complexes in the presence of ATP alone. Instead, formation of high molecular weight ParA2 polymers required DNA. Electron microscopy and three-dimensional reconstruction revealed that ParA2 formed bipolar helical filaments on double-stranded DNA in a sequence-independent manner. These filaments had a distinct change in pitch when ParA2 was polymerized in the presence of ATP versus in the absence of a nucleotide cofactor. Fitting a crystal structure of a ParA protein into our filament reconstruction showed how a dimer of ParA2 binds the DNA. The filaments formed with ATP are left-handed, but surprisingly these filaments exert no topological changes on the right-handed B-DNA to which they are bound. The stoichiometry of binding is one dimer for every eight base pairs, and this determines the geometry of the ParA2 filaments with 4.4 dimers per 120 A pitch left-handed turn. Our findings will be critical for understanding how ParA proteins function in plasmid and chromosome segregation.

  5. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  6. Transcription factor network downstream of protease activated receptors (PARs modulating mouse bladder inflammation

    Directory of Open Access Journals (Sweden)

    Hurst Robert E

    2007-08-01

    Full Text Available Abstract Background All four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders. Methods For this purpose, we used a protein/DNA combo array containing 345 different TF consensus sequences. Next, the TF selected was validated by EMSA and IHC. As mast cells seem to play a fundamental role in bladder inflammation, we determined whether c-kit receptor deficient (Kitw/Kitw-v mice have an abrogated response to PAR stimulation. Finally, TFEB antibody was used for CHIP/Q-PCR assay and revealed up-regulation of genes known to be downstream of TFEB. Results TFEB, a member of the MiTF family of basic helix-loop-helix leucine zipper, was the only TF commonly up-regulated by all PAR-APs. IHC results confirm a correlation between inflammation and TFEB expression in C57BL/6 mice. In contrast, Kitw/Kitw-v mice did not exhibit inflammation in response to PAR activation. EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice. Conclusion This is the first report describing the increased expression of TFEB in bladder inflammation in response to PAR activation. As TFEB belongs to a family of TFs essential for mast cell survival, our findings suggest that this molecule may influence the participation of mast cells in PAR-mediated inflammation and that targeting TFEB/MiTF activity may be a novel approach for the treatment of bladder inflammatory disorders.

  7. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  8. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily Kara

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  9. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  10. Secondary electron emission of thin carbon foils under the impact of hydrogen atoms, ions and molecular ions, under energies within the MeV range; Multiplicite des electrons secondaires emis par des cibles minces de carbone sous l'impact de projectiles H0, H2+, H3+ d'energie de l'ordre du MeV

    Energy Technology Data Exchange (ETDEWEB)

    Vidovic, Z

    1997-06-15

    This work focuses on the study of the emission statistics of secondary electrons from thin carbon foils bombarded with H{sup 0}, H{sub 2}{sup +} and H{sub 3}{sup +} projectiles in the 0.25-2.2 MeV energy range. The phenomenon of secondary electron emission from solids under the impact of swift ions is mainly due to inelastic interactions with target electrons. The phenomenological and theoretical descriptions, as well as a summary of the main theoretical models are the subject of the first chapter. The experimental set-up used to measure event by event the electron emission of the two faces of a thin carbon foil traversed by an energetic projectile is described in the chapter two. In this chapter are also presented the method and algorithms used to process experimental spectra in order to obtain the statistical distribution of the emitted electrons. Chapter three presents the measurements of secondary electron emission induced by H atoms passing through thin carbon foils. The secondary electron yields are studied in correlation with the emergent projectile charge state. We show the peculiar role of the projectile electron, whether it remains or not bound to the incident proton. The fourth chapter is dedicated to the secondary electron emission induced by H{sub 2}{sup +} and H{sub 3}{sup +} polyatomic ions. The results are interpreted in terms of collective effects in the interactions of these ions with solids. The role of the proximity of the protons, molecular ion fragments, upon the amplitude of these collective effects is evidenced from the study of the statistics of forward emission. These experiences allowed us to shed light on various aspects of atom and polyatomic ion inter-actions with solid surfaces. (author)

  11. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  12. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  13. Two-state conformational equilibrium in the Par-4 leucine zipper domain.

    Science.gov (United States)

    Schwalbe, Martin; Dutta, Kaushik; Libich, David S; Venugopal, Hariprasad; Claridge, Jolyon K; Gell, David A; Mackay, Joel P; Edwards, Patrick J B; Pascal, Steven M

    2010-08-15

    Prostate apoptosis response factor-4 (Par-4) is a pro-apoptotic and tumor-suppressive protein. A highly conserved heptad repeat sequence at the Par-4 C-terminus suggests the presence of a leucine zipper (LZ). This C-terminal region is essential for Par-4 self-association and interaction with various effector proteins. We have used nuclear magnetic resonance (NMR) spectroscopy to fully assign the chemical shift resonances of a peptide comprising the LZ domain of Par-4 at neutral pH. Further, we have investigated the properties of the Par-4 LZ domain and two point mutants under a variety of conditions using NMR, circular dichroism (CD), light scattering, and bioinformatics. Results indicate an environment-dependent conformational equilibrium between a partially ordered monomer (POM) and a predominantly coiled coil dimer (CCD). The combination of techniques used allows the time scales of the equilibrium to be probed and also helps to identify features of the amino acid sequence that may influence the equilibrium.

  14. Status of PAR Installation in Korean NPPs and Experiences in Regulatory Activities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Jae; Sung, Key Yong [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2010-10-15

    Following TMI-2 and Chernobyl accidents, concerns on the safety problems of nuclear power plants (NPPs) have been increased, especially for severe accident phenomena including hydrogen risk. To reduce the potential of hydrogen combustion, much of international efforts have been made for decades and it resulted in development of an innovative device, i.e. passive autocatalytic recombiner (PAR), for hydrogen removal in containment during an accident. On the designing and implementing a PAR, Bachellerie et al. provided a good instruction. Actually not only most new NPP designs but also NPPs to be refurbished are considering the installation of PARs for hydrogen control following a design basis accident (DBA) and severe accident (SA). For some Korean NPPs, the utility, KHNP, also has decided to equip PARs in containment and KINS has performed relevant regulatory reviews and preoperational inspections. In this paper, the status of PAR installation in Korean NPPs and KINS' experiences in regulatory activities including onsite findings as well as some recommendations, are described

  15. Protease-activated receptors (PARs) in cancer: Novel biased signaling and targets for therapy.

    Science.gov (United States)

    Bar-Shavit, R; Maoz, M; Kancharla, A; Jaber, M; Agranovich, D; Grisaru-Granovsky, S; Uziely, B

    2016-01-01

    Despite the fact that G protein-coupled receptors (GPCRs) mediate numerous physiological processes and represent targets for therapeutics for a vast array of diseases, their role in tumor biology is under appreciated. Protease-activated receptors (PARs) form a family which belongs to GPCR class A. PAR1&2 emerge with a central role in epithelial malignancies. Although the part of PAR1&2 in cancer is on the rise, their underlying signaling events are poorly understood. We review hereby past, present, and future cancer-associated PAR biology. Mainly, their role in physiological (placenta-cytotophobalst) and patho-physiological invasion processes. The identification and characterization of signal pleckstrin homology (PH)-domain-binding motifs established critical sites for breast cancer growth in PAR1&2. Among the proteins found to harbor important PH-domains and are involved in PAR biology are Akt/PKB as also Etk/Bmx and Vav3. A point mutation in PAR2, H349A, but not R352A, abrogated PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumor growth in vivo as also placental extravillous trophoblast (EVT) invasion in vitro is markedly reduced. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind PH-domain, inhibits mammary tumors and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26928551

  16. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  17. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  18. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  19. L'offre d'information volontaire par Internet et le gouvernement des entreprises françaises

    OpenAIRE

    Li, Li

    2010-01-01

    (VF)Cette recherche analyse le phénomène de la diffusion d’information par Internet en France. En prolongeant les études antérieures sur l’offre volontaire d’information, nous cherchons à savoir comment les facteurs du gouvernement d’entreprise influent sur la communication par voie électronique. Nous examinons également l’impact des caractéristiques des entreprises sur la publication volontaire par Internet. Les résultats montrent que l’offre d’information par Internet s’accroît lorsque la s...

  20. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.