WorldWideScience

Sample records for bio-medical x-ray imaging

  1. Bio-medical X-ray imaging with spectroscopic pixel detectors

    CERN Document Server

    Butler, A P H; Tipples, R; Cook, N; Watts, R; Meyer, J; Bell, A J; Melzer, T R; Butler, P H

    2008-01-01

    The aim of this study is to review the clinical potential of spectroscopic X-ray detectors and to undertake a feasibility study using a novel detector in a clinical hospital setting. Detectors currently in development, such as Medipix-3, will have multiple energy thresholds allowing for routine use of spectroscopic bio-medical imaging. We have coined the term MARS (Medipix All Resolution System) for bio-medical images that provide spatial, temporal, and energy information. The full clinical significance of spectroscopic X-ray imaging is difficult to predict but insights can be gained by examining both image reconstruction artifacts and the current uses of dual-energy techniques. This paper reviews the known uses of energy information in vascular imaging and mammography, clinically important fields. It then presents initial results from using Medipix-2, to image human tissues within a clinical radiology department. Detectors currently in development, such as Medipix-3, will have multiple energy thresholds allo...

  2. X-ray backscatter imaging

    Science.gov (United States)

    Dinca, Dan-Cristian; Schubert, Jeffrey R.; Callerame, J.

    2008-04-01

    In contrast to transmission X-ray imaging systems where inspected objects must pass between source and detector, Compton backscatter imaging allows both the illuminating source as well as the X-ray detector to be on the same side of the target object, enabling the inspection to occur rapidly and in a wide variety of space-constrained situations. A Compton backscatter image is similar to a photograph of the contents of a closed container, taken through the container walls, and highlights low atomic number materials such as explosives, drugs, and alcohol, which appear as especially bright objects by virtue of their scattering characteristics. Techniques for producing X-ray images based on Compton scattering will be discussed, along with examples of how these systems are used for both novel security applications and for the detection of contraband materials at ports and borders. Differences between transmission and backscatter images will also be highlighted. In addition, tradeoffs between Compton backscatter image quality and scan speed, effective penetration, and X-ray source specifications will be discussed.

  3. Soft X-ray Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Seely, John

    1999-05-20

    The contents of this report cover the following: (1) design of the soft x-ray telescope; (2) fabrication and characterization of the soft x-ray telescope; and (3) experimental implementation at the OMEGA laser facility.

  4. An Imaging X-Ray Polarimetry Mission

    Science.gov (United States)

    Weisskopf, Martin C.; Bellazini, Ronaldo; Costa, Enrico; Ramsey, Brian; O'Dell, Steve; Elsner, Ronald; Pavlov, George; Matt, Giorgio; Kaspi, Victoria; Tennant, Allyn; Coppi, Paolo; Wu, Kinwah; Siegmund, Oswald

    2008-01-01

    Technical progress both in x-ray optics and in polarization-sensitive x-ray detectors, which our groups have pioneered, enables a scientifically powerful---yet inexpensive---dedicated mission for imaging x-ray polarimetry. Such a mission is sufficiently sensitive to measure x-ray (linear) polarization for a broad range of cosmic sources --particularly those involving neutron stars, stellar black holes, and supermassive black holes (active galactic nuclei). We describe the technical elements, discuss a mission concept, and synopsize the important physical and astrophysical questions such a mission would address.

  5. Full-field transmission x-ray imaging with confocal polycapillary x-ray optics.

    Science.gov (United States)

    Sun, Tianxi; Macdonald, C A

    2013-02-07

    A transmission x-ray imaging setup based on a confocal combination of a polycapillary focusing x-ray optic followed by a polycapillary collimating x-ray optic was designed and demonstrated to have good resolution, better than the unmagnified pixel size and unlimited by the x-ray tube spot size. This imaging setup has potential application in x-ray imaging for small samples, for example, for histology specimens.

  6. Experimental x-ray ghost imaging

    CERN Document Server

    Pelliccia, Daniele; Scheel, Mario; Cantelli, Valentina; Paganin, David M

    2016-01-01

    We report an experimental proof of principle for ghost imaging in the hard x-ray energy range. We used a synchrotron x-ray beam that was split using a thin crystal in Laue diffraction geometry. With an ultra-fast imaging camera, we were able to image x-rays generated by isolated electron bunches. At this time scale, the shot noise of the synchrotron emission process is measurable as speckles, leading to speckle correlation between the two beams. The integrated transmitted intensity from a sample located in the first beam was correlated with the spatially resolved intensity measured on the second, empty, beam to retrieve the shadow of the sample. The demonstration of ghost imaging with hard x-rays may open the way to protocols to reduce radiation damage in medical imaging and in non-destructive structural characterization using Free Electron Lasers.

  7. Experimental X-Ray Ghost Imaging

    Science.gov (United States)

    Pelliccia, Daniele; Rack, Alexander; Scheel, Mario; Cantelli, Valentina; Paganin, David M.

    2016-09-01

    We report an experimental proof of principle for ghost imaging in the hard-x-ray energy range. We use a synchrotron x-ray beam that is split using a thin crystal in Laue diffraction geometry. With an ultrafast imaging camera, we are able to image x rays generated by isolated electron bunches. At this time scale, the shot noise of the synchrotron emission process is measurable as speckles, leading to speckle correlation between the two beams. The integrated transmitted intensity from a sample located in the first beam is correlated with the spatially resolved intensity measured in the second, empty, beam to retrieve the shadow of the sample. The demonstration of ghost imaging with hard x rays may open the way to protocols to reduce radiation damage in medical imaging and in nondestructive structural characterization using free electron lasers.

  8. Source effects in analyzer-based X-ray phase contrast imaging with conventional sources

    Energy Technology Data Exchange (ETDEWEB)

    Hoennicke, M. G. [Universidade Federal da Integracao Latino-Americana, 85867-970 Foz do Iguacu, PR (Brazil); Manica, J. [Universidade Estadual do Oeste do Parana, 85867-970 Foz do Iguacu, PR (Brazil); Mazzaro, I.; Cusatis, C. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Caixa Postal 19091, 81531-990 Curitiba, PR (Brazil); Huang, X.-R. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    2012-11-15

    Several recent papers have shown the implementation of analyzer based X-ray phase contrast imaging (ABI) with conventional X-ray sources. The high flux is always a requirement to make the technique useful for bio-medical applications. Here, we present and discuss three important parameters, which need to be taken into account, when searching for the high flux ABI: anisotropic magnification, double image, and source size spread due to intrinsic dispersive diffraction by asymmetrically cut crystals. These parameters, if not well optimized, may cause important features in the acquired images which can mislead the interpretation. A few ways to minimize these effects are implemented and discussed, including some experimental results.

  9. Speckle Scanning Based X-ray Imaging

    CERN Document Server

    Berujon, Sebastien

    2015-01-01

    The X-ray near field speckle scanning concept is an approach recently introduced to obtain absorption, phase and darkfield images of a sample. In this paper, we demonstrate ways of recovering from a sample its ultra-small angle X-ray scattering distribution using numerical deconvolution, and the 2D phase gradient signal from random step scans, the latter being used to elude the flat field correction error. Each feature is explained theoretically and demonstrated experimentally at a synchrotron X-ray facility.

  10. Single Particle X-ray Diffractive Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bogan, M J; Benner, W H; Boutet, S; Rohner, U; Frank, M; Seibert, M; Maia, F; Barty, A; Bajt, S; Riot, V; Woods, B; Marchesini, S; Hau-Riege, S P; Svenda, M; Marklund, E; Spiller, E; Hajdu, J; Chapman, H N

    2007-10-01

    In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas phase are critically important for surface modification and substrate-free characterization. Recent coherent diffractive imaging with intense femtosecond X-ray pulses has verified the capability of single-shot imaging of nanoscale objects at sub-optical resolutions beyond the radiation-induced damage threshold. By intercepting electrospray-generated particles with a single 15 femtosecond soft-X-ray pulse, we demonstrate diffractive imaging of a nanoscale specimen in free flight for the first time, an important step toward imaging uncrystallized biomolecules.

  11. Performance of a novel wafer scale CMOS active pixel sensor for bio-medical imaging.

    Science.gov (United States)

    Esposito, M; Anaxagoras, T; Konstantinidis, A C; Zheng, Y; Speller, R D; Evans, P M; Allinson, N M; Wells, K

    2014-07-07

    Recently CMOS active pixels sensors (APSs) have become a valuable alternative to amorphous silicon and selenium flat panel imagers (FPIs) in bio-medical imaging applications. CMOS APSs can now be scaled up to the standard 20 cm diameter wafer size by means of a reticle stitching block process. However, despite wafer scale CMOS APS being monolithic, sources of non-uniformity of response and regional variations can persist representing a significant challenge for wafer scale sensor response. Non-uniformity of stitched sensors can arise from a number of factors related to the manufacturing process, including variation of amplification, variation between readout components, wafer defects and process variations across the wafer due to manufacturing processes. This paper reports on an investigation into the spatial non-uniformity and regional variations of a wafer scale stitched CMOS APS. For the first time a per-pixel analysis of the electro-optical performance of a wafer CMOS APS is presented, to address inhomogeneity issues arising from the stitching techniques used to manufacture wafer scale sensors. A complete model of the signal generation in the pixel array has been provided and proved capable of accounting for noise and gain variations across the pixel array. This novel analysis leads to readout noise and conversion gain being evaluated at pixel level, stitching block level and in regions of interest, resulting in a coefficient of variation ⩽1.9%. The uniformity of the image quality performance has been further investigated in a typical x-ray application, i.e. mammography, showing a uniformity in terms of CNR among the highest when compared with mammography detectors commonly used in clinical practice. Finally, in order to compare the detection capability of this novel APS with the technology currently used (i.e. FPIs), theoretical evaluation of the detection quantum efficiency (DQE) at zero-frequency has been performed, resulting in a higher DQE for this

  12. Imaging in Hard X-ray Astronomy

    CERN Document Server

    Li Ti Pei

    2002-01-01

    The energy range of hard X-rays is a key waveband to the study of high energy processes in celestial objects, but still remains poorly explored. In contrast to direct imaging methods used in the low energy X-ray and high energy gamma-ray bands, currently imaging in the hard X-ray band is mainly achieved through various modulation techniques. A new inversion technique, the direct demodulation method, has been developed since early 90s. With this technique, wide field and high resolution images can be derived from scanning data of a simple collimated detector. The feasibility of this technique has been confirmed by experiment, balloon-borne observation and analyzing simulated and real astronomical data. Based the development of methodology and instrumentation, a high energy astrophysics mission -- Hard X-ray Modulation Telescope (HXMT) has been proposed and selected in China for a four-year Phase-A study. The main scientific objectives are a full-sky hard X-ray (20-200 keV) imaging survey and high signal-to-noi...

  13. The X-ray imager on AXO

    Science.gov (United States)

    Budtz-Jørgensen, C.; Kuvvetli, I.; Westergaard, N. J.; Jonasson, P.; Reglero, V.; Eyles, C.

    2001-02-01

    DSRI has initiated a development program of CZT X-ray and gamma-ray detectors employing strip readout techniques. A dramatic improvement of the energy response was found operating the detectors as the so-called drift detectors. For the electronic readout, modern ASIC chips were investigated. Modular design and the low-power electronics will make large area detectors using the drift strip method feasible. The performance of a prototype CZT system will be presented and discussed. One such detector system has been proposed for future space missions: the X-Ray Imager (XRI) on the Atmospheric X-ray Observatory (AXO), which is a mission proposed to the Danish Small Satellite Program and is dedicated to observations of X-ray generating processes in the Earth's atmosphere. Of special interest will be simultaneous optical and X-ray observations of sprites that are flashes appearing directly above an active thunderstorm system. Additional objective is a detailed mapping of the auroral X-ray and optical emission. XRI comprises a coded mask and a 20×40 cm 2 CZT detector array covering an energy range from 5 to 200 keV.

  14. X-ray imaging: Perovskites target X-ray detection

    Science.gov (United States)

    Heiss, Wolfgang; Brabec, Christoph

    2016-05-01

    Single crystals of perovskites are currently of interest to help fathom fundamental physical parameters limiting the performance of perovskite-based polycrystalline solar cells. Now, such perovskites offer a technology platform for optoelectronic devices, such as cheap and sensitive X-ray detectors.

  15. Imaging plates calibration to X-rays

    Science.gov (United States)

    Curcio, A.; Andreoli, P.; Cipriani, M.; Claps, G.; Consoli, F.; Cristofari, G.; De Angelis, R.; Giulietti, D.; Ingenito, F.; Pacella, D.

    2016-05-01

    The growing interest for the Imaging Plates, due to their high sensitivity range and versatility, has induced, in the last years, to detailed characterizations of their response function in different energy ranges and kind of radiation/particles. A calibration of the Imaging Plates BAS-MS, BAS-SR, BAS-TR has been performed at the ENEA-Frascati labs by exploiting the X-ray fluorescence of different targets (Ca, Cu, Pb, Mo, I, Ta) and the radioactivity of a BaCs source, in order to cover the X-ray range between few keV to 80 keV.

  16. First X-ray fluorescence CT experimental results at the SSRF X-ray imaging beamline

    Institute of Scientific and Technical Information of China (English)

    DENG Biao; YANG Qun; XIE Hong-Lan; DU Guo-Hao; XIAO Wi-Qiao

    2011-01-01

    X-ray fluorescence CT is a non-destructive technique for detecting elemental composition and distribution inside a specimen. In this paper, the first experimental results of X-ray fluorescence CT obtained at the SSRF X-ray imaging beamline (BL13W1) are described. The test samples were investigated and the 2D elemental image was reconstructed using a filtered back-projection algorithm. In the sample the element Cd was observed. Up to now, the X-ray fluorescence CT could be carried out at the SSRF X-ray imaging beamline.

  17. The X-ray imager on AXO

    DEFF Research Database (Denmark)

    Budtz-Jørgensen, Carl; Kuvvetli, Irfan; Westergaard, Niels Jørgen Stenfeldt

    2001-01-01

    DSRI has initiated a development program of CZT X-ray and gamma-ray detectors employing strip readout techniques. A dramatic improvement of the energy response was found operating the detectors as the so-called drift detectors. For the electronic readout, modern ASIC chips were investigated....... Modular design and the low-power electronics will make large area detectors using the drift strip method feasible. The performance of a prototype CZT system will be presented and discussed. One such detector system has been proposed for future space missions: the X-Ray Imager (XRI) on the Atmospheric X...... thunderstorm system. Additional objective is a detailed mapping of the auroral X-ray and optical emission. XRI comprises a coded mask and a 20 x 40cm(2) CZT detector array covering an energy range from 5 to 200keV....

  18. Differential phase contrast X-ray imaging system and components

    Science.gov (United States)

    Stutman, Daniel; Finkenthal, Michael

    2014-07-01

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  19. Differential phase contrast X-ray imaging system and components

    Energy Technology Data Exchange (ETDEWEB)

    Stutman, Daniel; Finkenthal, Michael

    2017-01-31

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  20. Enhanced dynamic range x-ray imaging.

    Science.gov (United States)

    Haidekker, Mark A; Morrison, Logan Dain-Kelley; Sharma, Ajay; Burke, Emily

    2017-03-01

    X-ray images can suffer from excess contrast. Often, image exposure is chosen to visually optimize the region of interest, but at the expense of over- and underexposed regions elsewhere in the image. When image values are interpreted quantitatively as projected absorption, both over- and underexposure leads to the loss of quantitative information. We propose to combine multiple exposures into a composite that uses only pixels from those exposures in which they are neither under- nor overexposed. The composite image is created in analogy to visible-light high dynamic range photography. We present the mathematical framework for the recovery of absorbance from such composite images and demonstrate the method with biological and non-biological samples. We also show with an aluminum step-wedge that accurate recovery of step thickness from the absorbance values is possible, thereby highlighting the quantitative nature of the presented method. Due to the higher amount of detail encoded in an enhanced dynamic range x-ray image, we expect that the number of retaken images can be reduced, and patient exposure overall reduced. We also envision that the method can improve dual energy absorptiometry and even computed tomography by reducing the number of low-exposure ("photon-starved") projections.

  1. Phosphor Scanner For Imaging X-Ray Diffraction

    Science.gov (United States)

    Carter, Daniel C.; Hecht, Diana L.; Witherow, William K.

    1992-01-01

    Improved optoelectronic scanning apparatus generates digitized image of x-ray image recorded in phosphor. Scanning fiber-optic probe supplies laser light stimulating luminescence in areas of phosphor exposed to x rays. Luminescence passes through probe and fiber to integrating sphere and photomultiplier. Sensitivity and resolution exceed previously available scanners. Intended for use in x-ray crystallography, medical radiography, and molecular biology.

  2. Digital X-ray Imaging in Dentistry

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun Kyung [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Dankook University, Yongin (Korea, Republic of)

    1999-08-15

    In dentistry, Radio Visio Graphy was introduced as a first electronic dental x-ray imaging modality in 1989. Thereafter, many types of direct digital radiographic systems have been produced in the last decade. They are based either on charge-coupled device (CCD) or on storage phosphor technology. In addition, new types of digital radiographic system using amorphous selenium, image intensifier etc. are under development. Advantages of digital radiographic system are elimination of chemical processing, reduction in radiation dose, image processing, computer storage, electronic transfer of images and so on. Image processing includes image enhancement, image reconstruction, digital subtraction, etc. Especially digital subtraction and reconstruction can be applied in many aspects of clinical practice and research. Electronic transfer of images enables filmless dental hospital and teleradiology/teledentistry system. Since the first image management and communications system (IMACS) for dentomaxillofacial radiology was reported in 1992, IMACS in dental hospital has been increasing. Meanwhile, researches about computer-assisted diagnosis, such as structural analysis of bone trabecular patterns of mandible, feature extraction, automated identification of normal landmarks on cephalometric radiograph and automated image analysis for caries or periodontitis, have been performed actively in the last decade. Further developments in digital radiographic imaging modalities, image transmission system, imaging processing and automated analysis software will change the traditional clinical dental practice in the 21st century.

  3. Image processing system for digital chest X-ray images

    Energy Technology Data Exchange (ETDEWEB)

    Cocklin, M.; Gourlay, A.; Jackson, P.; Kaye, G.; Miessler, M. (I.B.M. U.K. Scientific Centre, Winchester (UK)); Kerr, I.; Lams, P. (Radiology Department, Brompton Hospital, London (UK))

    1984-01-01

    This paper investigates the requirements for image processing of digital chest X-ray images. These images are conventionally recorded on film and are characterised by large size, wide dynamic range and high resolution. X-ray detection systems are now becoming available for capturing these images directly in photoelectronic-digital form. The hardware and software facilities required for handling these images are described. These facilities include high resolution digital image displays, programmable video look up tables, image stores for image capture and processing and a full range of software tools for image manipulation. Examples are given of the applications of digital image processing techniques to this class of image.

  4. Anisotropic imaging performance in indirect x-ray imaging detectors.

    Science.gov (United States)

    Badano, Aldo; Kyprianou, Iacovos S; Sempau, Josep

    2006-08-01

    We report on the variability in imaging system performance due to oblique x-ray incidence, and the associated transport of quanta (both x rays and optical photons) through the phosphor, in columnar indirect digital detectors. The analysis uses MANTIS, a combined x-ray, electron, and optical Monte Carlo transport code freely available. We describe the main features of the simulation method and provide some validation of the phosphor screen models considered in this work. We report x-ray and electron three-dimensional energy deposition distributions and point-response functions (PRFs), including optical spread in columnar phosphor screens of thickness 100 and 500 microm, for 19, 39, 59, and 79 keV monoenergetic x-ray beams incident at 0 degrees, 10 degrees, and 15 degrees. In addition, we present pulse-height spectra for the same phosphor thickness, x-ray energies, and angles of incidence. Our results suggest that the PRF due to the phosphor blur is highly nonsymmetrical, and that the resolution properties of a columnar screen in a tomographic, or tomosynthetic imaging system varies significantly with the angle of x-ray incidence. Moreover, we find that the noise due to the variability in the number of light photons detected per primary x-ray interaction, summarized in the information or Swank factor, is somewhat independent of thickness and incidence angle of the x-ray beam. Our results also suggest that the anisotropy in the PRF is not less in screens with absorptive backings, while the noise introduced by variations in the gain and optical transport is larger. Predictions from MANTIS, after additional validation, can provide the needed understanding of the extent of such variations, and eventually, lead to the incorporation of the changes in imaging performance with incidence angle into the reconstruction algorithms for volumetric x-ray imaging systems.

  5. Coded Aperture Imaging for Fluorescent X-rays-Biomedical Applications

    Energy Technology Data Exchange (ETDEWEB)

    Haboub, Abdel; MacDowell, Alastair; Marchesini, Stefano; Parkinson, Dilworth

    2013-06-01

    Employing a coded aperture pattern in front of a charge couple device pixilated detector (CCD) allows for imaging of fluorescent x-rays (6-25KeV) being emitted from samples irradiated with x-rays. Coded apertures encode the angular direction of x-rays and allow for a large Numerical Aperture x- ray imaging system. The algorithm to develop the self-supported coded aperture pattern of the Non Two Holes Touching (NTHT) pattern was developed. The algorithms to reconstruct the x-ray image from the encoded pattern recorded were developed by means of modeling and confirmed by experiments. Samples were irradiated by monochromatic synchrotron x-ray radiation, and fluorescent x-rays from several different test metal samples were imaged through the newly developed coded aperture imaging system. By choice of the exciting energy the different metals were speciated.

  6. X-ray holographic microscopy: Improved images of zymogen granules

    Energy Technology Data Exchange (ETDEWEB)

    Jacobsen, C.; Howells, M.; Kirz, J.; McQuaid, K.; Rothman, S.

    1988-10-01

    Soft x-ray holography has long been considered as a technique for x-ray microscopy. It has been only recently, however, that sub-micron resolution has been obtained in x-ray holography. This paper will concentrate on recent progress we have made in obtaining reconstructed images of improved quality. 15 refs., 6 figs.

  7. The ITER core imaging x-ray spectrometer: x-ray calorimeter performance.

    Science.gov (United States)

    Beiersdorfer, P; Brown, G V; Clementson, J; Dunn, J; Morris, K; Wang, E; Kelley, R L; Kilbourne, C A; Porter, F S; Bitter, M; Feder, R; Hill, K W; Johnson, D; Barnsley, R

    2010-10-01

    We describe the anticipated performance of an x-ray microcalorimeter instrument on ITER. As part of the core imaging x-ray spectrometer, the instrument will augment the imaging crystal spectrometers by providing a survey of the concentration of heavy ion plasma impurities in the core and possibly ion temperature values from the emission lines of different elemental ions located at various radial positions.

  8. X-ray diffraction imaging of material microstructures

    KAUST Repository

    Varga, Laszlo

    2016-10-20

    Various examples are provided for x-ray imaging of the microstructure of materials. In one example, a system for non-destructive material testing includes an x-ray source configured to generate a beam spot on a test item; a grid detector configured to receive x- rays diffracted from the test object; and a computing device configured to determine a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the test object. In another example, a method for determining a microstructure of a material includes illuminating a beam spot on the material with a beam of incident x-rays; detecting, with a grid detector, x-rays diffracted from the material; and determining, by a computing device, a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the material.

  9. X-Ray Phase Imaging for Breast Cancer Detection

    Science.gov (United States)

    2011-09-01

    A. Yan, X. Wu, and H. Liu, Robustness of phase retrieval methods in x-ray phase contrast imaging: A comparison, Medical Physics 38: 5073-5080...2004. A new theory of phase-contrast x-ray imaging based on Wigner distributions. Medical Physics 31, 2378-2384. Wu X, Liu, H, Yan, A. 2005...Yan A., Wu X., Liu H. 2011. Robustness of phase retrieval methods in x-ray phase contrast imaging: A comparison, Medical Physics 38: 5073-5080

  10. X-ray imaging with the PILATUS 100k detector

    DEFF Research Database (Denmark)

    Bech, Martin; Bunk, O.; David, C.;

    2008-01-01

    We report on the application of the PILATUS 100K pixel detector for medical imaging. Experimental results are presented in the form of X-ray radiographs using standard X-ray absorption contrast and a recently developed phase contrast imaging method. The results obtained with the PILATUS detector...... are compared to results obtained with a conventional X-ray imaging system consisting of an X-ray scintillation screen, lens optics, and a charge coupled device. Finally, the results for both systems are discussed more quantitatively based on an image power spectrum analysis. Udgivelsesdato: April...

  11. CMOS APS detector characterization for quantitative X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Endrizzi, Marco, E-mail: m.endrizzi@ucl.ac.uk [Dipartimento di Fisica, Università di Siena, Via Roma 56, 53100 Siena (Italy); Istituto Nazionale di Fisica Nucleare INFN, sezione di Pisa, 56127 Pisa (Italy); Oliva, Piernicola [Dipartimento di Chimica e Farmacia, Università di Sassari, via Piandanna 4, 07100 Sassari (Italy); Istituto Nazionale di Fisica Nucleare INFN, Sezione di Cagliari, 09042 Cagliari (Italy); Golosio, Bruno [Sezione di Matematica, Fisica e Ingegneria dell' Informazione, Università di Sassari, via Piandanna 4, 07100 Sassari (Italy); Istituto Nazionale di Fisica Nucleare INFN, Sezione di Cagliari, 09042 Cagliari (Italy); Delogu, Pasquale [Dipartimento di Fisica “E. Fermi”, Università di Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Istituto Nazionale di Fisica Nucleare INFN, sezione di Pisa, 56127 Pisa (Italy)

    2013-03-01

    An X-ray Imaging detector based on CMOS Active Pixel Sensor and structured scintillator is characterized for quantitative X-ray imaging in the energy range 11–30 keV. Linearity, dark noise, spatial resolution and flat-field correction are the characteristics of the detector subject of investigation. The detector response, in terms of mean Analog-to-Digital Unit and noise, is modeled as a function of the energy and intensity of the X-rays. The model is directly tested using monochromatic X-ray beams and it is also indirectly validated by means of polychromatic X-ray-tube spectra. Such a characterization is suitable for quantitative X-ray imaging and the model can be used in simulation studies that take into account the actual performance of the detector.

  12. Tuberculosis, advanced - chest x-rays (image)

    Science.gov (United States)

    Tuberculosis is an infectious disease that causes inflammation, the formation of tubercules and other growths within tissue, ... death. These chest x-rays show advanced pulmonary tuberculosis. There are multiple light areas (opacities) of varying ...

  13. Quantitative phase imaging using hard x-rays

    Energy Technology Data Exchange (ETDEWEB)

    Nugent, K.A.; Paganin, D.; Barnea, Z. [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Cookson, D. F. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia); Gureyev, T.E. [Melbourne Univ., Parkville, VIC (Australia). School of Physics]|[CSIRO, Clayton, VIC (Australia). Div. of Forestry and Forest Products

    1997-06-01

    The quantitative imaging of a phase object using 16 keV x-rays is reported. The theoretical basis of the techniques is presented along with its implementation using a synchrotron x-ray source. It is found that the phase image is in quantitative agreement with independent measurements of the object. 13 refs., 5 figs.

  14. Quantitative cone beam X-ray luminescence tomography/X-ray computed tomography imaging

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dongmei; Zhu, Shouping, E-mail: zhusp2009@gmail.com; Chen, Xueli; Chao, Tiantian; Cao, Xu; Zhao, Fengjun; Huang, Liyu; Liang, Jimin [Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education and School of Life Science and Technology, Xidian University, Xi' an, Shaanxi 710071 (China)

    2014-11-10

    X-ray luminescence tomography (XLT) is an imaging technology based on X-ray-excitable materials. The main purpose of this paper is to obtain quantitative luminescence concentration using the structural information of the X-ray computed tomography (XCT) in the hybrid cone beam XLT/XCT system. A multi-wavelength luminescence cone beam XLT method with the structural a priori information is presented to relieve the severe ill-posedness problem in the cone beam XLT. The nanophosphors and phantom experiments were undertaken to access the linear relationship of the system response. Then, an in vivo mouse experiment was conducted. The in vivo experimental results show that the recovered concentration error as low as 6.67% with the location error of 0.85 mm can be achieved. The results demonstrate that the proposed method can accurately recover the nanophosphor inclusion and realize the quantitative imaging.

  15. X-Ray Imaging Crystal Spectrometer for Extended X-Ray Sources

    Energy Technology Data Exchange (ETDEWEB)

    Bitter, Manfred L.; Fraekel, Benjamin; Gorman, James L.; Hill, Kenneth W.; Roquemore, Lane A.; Stodiek, Wolfgang; Goeler, Schweickhard von

    1999-05-01

    Spherically or toroidally curved, double focusing crystals are used in a spectrometer for X-ray diagnostics of an extended X-ray source such as a hot plasma produced in a tokamak fusion experiment to provide spatially and temporally resolved data on plasma parameters such as ion temperature, toroidal and poloidal rotation, electron temperature, impurity ion charge-state distributions, and impurity transport. The imaging properties of these spherically or toroidally curved crystals provide both spectrally and spatially resolved X-ray data from the plasma using only one small spherically or toroidally curved crystal, thus eliminating the requirement for a large array of crystal spectrometers and the need to cross-calibrate the various crystals.

  16. Incoherent x-ray scattering in single molecule imaging

    CERN Document Server

    Slowik, Jan Malte; Dixit, Gopal; Jurek, Zoltan; Santra, Robin

    2014-01-01

    Imaging of the structure of single proteins or other biomolecules with atomic resolution would be enormously beneficial to structural biology. X-ray free-electron lasers generate highly intense and ultrashort x-ray pulses, providing a route towards imaging of single molecules with atomic resolution. The information on molecular structure is encoded in the coherent x-ray scattering signal. In contrast to crystallography there are no Bragg reflections in single molecule imaging, which means the coherent scattering is not enhanced. Consequently, a background signal from incoherent scattering deteriorates the quality of the coherent scattering signal. This background signal cannot be easily eliminated because the spectrum of incoherently scattered photons cannot be resolved by usual scattering detectors. We present an ab initio study of incoherent x-ray scattering from individual carbon atoms, including the electronic radiation damage caused by a highly intense x-ray pulse. We find that the coherent scattering pa...

  17. Calibration of Cone Beam Rotational X-Ray Image Sequence

    Institute of Scientific and Technical Information of China (English)

    YUHengyong; MOUXuanqin; CAIYuanlong

    2004-01-01

    The real X-ray projection does not abide by Lambert-Beer Law, since the X-ray is polychromatic and the imaging chains are nonlinear. Based on the generating process of X-ray images, an equivalent nonlinear transform model is firstly proposed which considers all the nonlinear factors as one nonlinear transform. Then the 3D (three-dimensional) X-ray projection of cone beam is defined. The constraints of Radon transform, named H-L (Helgasson-ludwig) consistency conditions, are expanded to fan-beam. After that an algorithm is developed to calibrate Rotational X-ray image sequence (RXIS). The algorithm uses a set of exponential functions to approximate the nonlinear inverse transform. According to expanded H-L consistency conditions, finally a kind of nonlinear measure for RXIS is defined. Experimental results show that the proposed algorithm can decrease the nonlinear measure to below 0.01.

  18. Infrared Radiography: Modeling X-ray Imaging without Harmful Radiation

    Science.gov (United States)

    Zietz, Otto; Mylott, Elliot; Widenhorn, Ralf

    2015-01-01

    Planar x-ray imaging is a ubiquitous diagnostic tool and is routinely performed to diagnose conditions as varied as bone fractures and pneumonia. The underlying principle is that the varying attenuation coefficients of air, water, tissue, bone, or metal implants within the body result in non-uniform transmission of x-ray radiation. Through the…

  19. Comparing neutron and X-ray images from NIF implosions

    Directory of Open Access Journals (Sweden)

    Wilson D.C.

    2013-11-01

    Full Text Available Directly laser driven and X-radiation driven DT filled capsules differ in the relationship between neutron and X-ray images. Shot N110217, a directly driven DT-filled glass micro-balloon provided the first neutron images at the National Ignition Facility. As seen in implosions on the Omega laser, the neutron image can be enclosed inside time integrated X-ray images. HYDRA simulations show the X-ray image is dominated by emission from the hot glass shell while the neutron image arises from the DT fuel it encloses. In the absence of mix or jetting, X-ray images of a cryogenically layered THD fuel capsule should be dominated by emission from the hydrogen rather than the cooler plastic shell that is separated from the hot core by cold DT fuel. This cool, dense DT, invisible in X-ray emission, shows itself by scattering hot core neutrons. Germanium X-ray emission spectra and Ross pair filtered X-ray energy resolved images suggest that germanium doped plastic emits in the torus shaped hot spot, probably reducing the neutron yield.

  20. Comment on "Perspectives of medical X-ray imaging"

    CERN Document Server

    Taibi, A; Tuffanelli, A; Gambaccini, M

    2002-01-01

    In the paper 'Perspectives of medical X-ray imaging' (Nucl. Instr. and Meth. A 466 (2001) 99) the infer, from simple approximations, that the use of HOPG monochromator has no advantage in mammography compared to existing systems. We show that in order to compare imaging properties of different X-ray sources it is necessary to evaluate the spectra after the attenuation of the tissue to be imaged. Indeed, quasi-monochromatic X-ray sources have the potential to enhance image contrast and to reduce patient dose.

  1. Hard X-ray Microscopic Imaging Of Human Breast Tissues

    Science.gov (United States)

    Park, Sung H.; Kim, Hong T.; Kim, Jong K.; Jheon, Sang H.; Youn, Hwa S.

    2007-01-01

    X-ray microscopy with synchrotron radiation will be a useful tool for innovation of x-ray imaging in clinical and laboratory settings. It helps us observe detailed internal structure of material samples non-invasively in air. And, it also has the potential to solve some tough problems of conventional breast imaging if it could evaluate various conditions of breast tissue effectively. A new hard x-ray microscope with a spatial resolution better than 100 nm was installed at Pohang Light Source, a third generation synchrotron radiation facility in Pohang, Korea. The x-ray energy was set at 6.95 keV, and the x-ray beam was monochromatized by W/B4C monochromator. Condenser and objective zone plates were used as x-ray lenses. Zernike phase plate next to condenser zone plate was introduced for improved contrast imaging. The image of a sample was magnified 30 times by objective zone plate and 20 times by microscope objective, respectively. After additional 10 times digital magnification, the total magnifying power was up to 6000 times in the end. Phase contrast synchrotron images of 10-μm-thick female breast tissue of the normal, fibroadenoma, fibrocystic change and carcinoma cases were obtained. By phase contrast imaging, hard x-rays enable us to observe many structures of breast tissue without sample preparations such as staining or fixation.

  2. Utilizing broadband X-rays in a Bragg coherent X-ray diffraction imaging experiment.

    Science.gov (United States)

    Cha, Wonsuk; Liu, Wenjun; Harder, Ross; Xu, Ruqing; Fuoss, Paul H; Hruszkewycz, Stephan O

    2016-09-01

    A method is presented to simplify Bragg coherent X-ray diffraction imaging studies of complex heterogeneous crystalline materials with a two-stage screening/imaging process that utilizes polychromatic and monochromatic coherent X-rays and is compatible with in situ sample environments. Coherent white-beam diffraction is used to identify an individual crystal particle or grain that displays desired properties within a larger population. A three-dimensional reciprocal-space map suitable for diffraction imaging is then measured for the Bragg peak of interest using a monochromatic beam energy scan that requires no sample motion, thus simplifying in situ chamber design. This approach was demonstrated with Au nanoparticles and will enable, for example, individual grains in a polycrystalline material of specific orientation to be selected, then imaged in three dimensions while under load.

  3. Utilizing broadband X-rays in a Bragg coherent X-ray diffraction imaging experiment

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Wonsuk; Liu, Wenjun; Harder, Ross; Xu, Ruqing; Fuoss, Paul H.; Hruszkewycz, Stephan O.

    2016-07-26

    A method is presented to simplify Bragg coherent X-ray diffraction imaging studies of complex heterogeneous crystalline materials with a two-stage screening/imaging process that utilizes polychromatic and monochromatic coherent X-rays and is compatible within situsample environments. Coherent white-beam diffraction is used to identify an individual crystal particle or grain that displays desired properties within a larger population. A three-dimensional reciprocal-space map suitable for diffraction imaging is then measured for the Bragg peak of interest using a monochromatic beam energy scan that requires no sample motion, thus simplifyingin situchamber design. This approach was demonstrated with Au nanoparticles and will enable, for example, individual grains in a polycrystalline material of specific orientation to be selected, then imaged in three dimensions while under load.

  4. AXIOM: Advanced X-Ray Imaging Of the Magnetosheath

    Science.gov (United States)

    Sembay, S.; Branduardi-Rayrnont, G.; Eastwood, J. P.; Sibeck, D. G.; Abbey, A.; Brown, P.; Carter, J. A.; Carr, C. M.; Forsyth, C; Kataria, D.; Kemble, S.; Milan, S.; Owen, C. J.; Read, A. M.; Peacocke, L.; Arridge, C. S.; Coates, A. J.; Collier, M. R.; Cowley, S. W. H.; Fazakerley, A. N.; Fraser, G.; Jones, G. H.; Lallement, R.; Lester, M.; Porter, F. S.

    2012-01-01

    AXIOM (Advanced X-ray Imaging Of the Magnetosphere) is a concept mission which aims to explain how the Earth's magnetosphere responds to the changing impact of the solar wind using a unique method never attempted before; performing wide-field soft X-ray imaging and spectroscopy of the magnetosheath. magnetopause and bow shock at high spatial and temporal resolution. Global imaging of these regions is possible because of the solar wind charge exchange (SWCX) process which produces elevated soft X-ray emission from the interaction of high charge-state solar wind ions with primarily neutral hydrogen in the Earth's exosphere and near-interplanetary space.

  5. Analyzer-based phase-contrast imaging system using a micro focus x-ray source

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Wei [BME Department, Illinois Institute of Technology, Chicago, Illinois 60616 (United States); Majidi, Keivan; Brankov, Jovan G., E-mail: brankov@iit.edu [ECE Department, Illinois Institute of Technology, Chicago, Illinois 60616 (United States)

    2014-08-15

    Here we describe a new in-laboratory analyzer based phase contrast-imaging (ABI) instrument using a conventional X-ray tube source (CXS) aimed at bio-medical imaging applications. Phase contrast-imaging allows visualization of soft tissue details usually obscured in conventional X-ray imaging. The ABI system design and major features are described in detail. The key advantage of the presented system, over the few existing CXS ABI systems, is that it does not require high precision components, i.e., CXS, X-ray detector, and electro-mechanical components. To overcome a main problem introduced by these components, identified as temperature stability, the system components are kept at a constant temperature inside of three enclosures, thus minimizing the electrical and mechanical thermal drifts. This is achieved by using thermoelectric (Peltier) cooling/heating modules that are easy to control precisely. For CXS we utilized a microfocus X-ray source with tungsten (W) anode material. In addition the proposed system eliminates tungsten's multiple spectral lines by selecting monochromator crystal size appropriately therefore eliminating need for the costly mismatched, two-crystal monochromator. The system imaging was fine-tuned for tungsten Kα{sub 1} line with the energy of 59.3 keV since it has been shown to be of great clinical significance by a number of researchers at synchrotron facilities. In this way a laboratory system that can be used for evaluating and quantifying tissue properties, initially explored at synchrotron facilities, would be of great interest to a larger research community. To demonstrate the imaging capability of our instrument we use a chicken thigh tissue sample.

  6. Stimulated scintillation emission depletion X-ray imaging.

    Science.gov (United States)

    Alekhin, M S; Patton, G; Dujardin, C; Douissard, P-A; Lebugle, M; Novotny, L; Stampanoni, M

    2017-01-23

    X-ray microtomography is a widely applied tool for noninvasive structure investigations. The related detectors are usually based on a scintillator screen for the fast in situ conversion of an X-ray image into an optical image. Spatial resolution of the latter is fundamentally diffraction limited. In this work, we introduce stimulated scintillation emission depletion (SSED) X-ray imaging where, similar to stimulated emission depletion (STED) microscopy, a depletion beam is applied to the scintillator screen to overcome the diffraction limit. The requirements for the X-ray source, the X-ray flux, the scintillator screen, and the STED beam were evaluated. Fundamental spatial resolution limits due to the spread of absorbed X-ray energy were estimated with Monte Carlo simulations. The SSED proof-of-concept experiments demonstrated 1) depletion of X-ray excited scintillation, 2) partial confinement of scintillating regions to sub-diffraction sized volumes, and 3) improvement of the imaging contrast by applying SSED.

  7. Characterizing Complexity of Containerized Cargo X-ray Images

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guangxing [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Martz, Harry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, Steven [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divin, Charles [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Birrer, Nat [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-19

    X-ray imaging can be used to inspect cargos imported into the United States. In order to better understand the performance of X-ray inspection systems, the X-ray characteristics (density, complexity) of cargo need to be quantified. In this project, an image complexity measure called integrated power spectral density (IPSD) was studied using both DNDO engineered cargos and stream-of-commerce (SOC) cargos. A joint distribution of cargo density and complexity was obtained. A support vector machine was used to classify the SOC cargos into four categories to estimate the relative fractions.

  8. Three-Dimensional Backscatter X-Ray Imaging System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall objective of the proposal is to design, develop and demonstrate a potentially portable Compton x-ray scatter 3D-imaging system by using specially...

  9. Correction of ring artifacts in X-ray tomographic images

    DEFF Research Database (Denmark)

    Lyckegaard, Allan; Johnson, G.; Tafforeau, P.

    2011-01-01

    Ring artifacts are systematic intensity distortions located on concentric circles in reconstructed tomographic X-ray images. When using X-ray tomography to study for instance low-contrast grain boundaries in metals it is crucial to correct for the ring artifacts in the images as they may have...... the same intensity level as the grain boundaries and thus make it impossible to perform grain segmentation. This paper describes an implementation of a method for correcting the ring artifacts in tomographic X-ray images of simple objects such as metal samples where the object and the background...... are separable. The method is implemented in Matlab, it works with very little user interaction and may run in parallel on a cluster if applied to a whole stack of images. The strength and robustness of the method implemented will be demonstrated on three tomographic X-ray data sets: a mono-phase β...

  10. GOES-12 Solar X-ray Imager Archive

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The GOES Solar X-ray Imager is integrated into the GOES-12 satellite, whose primary mission is to provide Earth-weather monitoring. The SXI is operated by NOAA's...

  11. Digitization and DICOM Standardization of X-ray Image Signal

    Institute of Scientific and Technical Information of China (English)

    ZHOU Li; YANG Xuan-dong; LI Kai-yang

    2004-01-01

    Picture archiving and communication system (PACS) has played an important role in hospital and developed rapidly in recent years. It is an important part of PACS architecture that X-ray video output connects with PACS. In this paper, a method to digitize the video signals of X-ray facility is introduced. By means of the video capture card, we can acquire digital medical images from X-ray facility. The American College of Radiology (ACR) and the National Electrical Manufacturers Association (NEMA) developed a standard for Digital Imaging and Communications in Medicine (DICOM), this DICOM standard introduces a rule of medical image conversion from conventional format to DICOM one. According to above-mentioned standard, X-ray video signals can be connected to PACS easily. This project has been applied in some hospitals successfully and there is satisfied result.

  12. Applications of Indirect Imaging techniques in X-ray binaries

    CERN Document Server

    Harlaftis, E T

    2000-01-01

    A review is given on aspects of indirect imaging techniques in X-ray binaries which are used as diagnostics tools for probing the X-ray dominated accretion disc physics. These techniques utilize observed properties such as the emission line profile variability, the time delays between simultaneous optical/X-ray light curves curves, the light curves of eclipsing systems and the pulsed emission from the compact object in order to reconstruct the accretion disc's line emissivity (Doppler tomography), the irradiated disc and heated secondary (echo mapping), the outer disc structure (modified eclipse mapping) and the accreting regions onto the compact object, respectively.

  13. Acoustically modulated x-ray phase contrast imaging.

    Science.gov (United States)

    Hamilton, Theron J; Bailat, Claude J; Rose-Petruck, Christoph; Diebold, Gerald J

    2004-11-07

    We report the use of ultrasonic radiation pressure with phase contrast x-ray imaging to give an image proportional to the space derivative of a conventional phase contrast image in the direction of propagation of an ultrasonic beam. Intense ultrasound is used to exert forces on objects within a body giving displacements of the order of tens to hundreds of microns. Subtraction of images made with and without the ultrasound field gives an image that removes low spatial frequency features and highlights high frequency features. The method acts as an acoustic 'contrast agent' for phase contrast x-ray imaging, which in soft tissue acts to highlight small density changes.

  14. [The application of X-ray imaging in forensic medicine].

    Science.gov (United States)

    Kučerová, Stěpánka; Safr, Miroslav; Ublová, Michaela; Urbanová, Petra; Hejna, Petr

    2014-07-01

    X-ray is the most common, basic and essential imaging method used in forensic medicine. It serves to display and localize the foreign objects in the body and helps to detect various traumatic and pathological changes. X-ray imaging is valuable in anthropological assessment of an individual. X-ray allows non-invasive evaluation of important findings before the autopsy and thus selection of the optimal strategy for dissection. Basic indications for postmortem X-ray imaging in forensic medicine include gunshot and explosive fatalities (identification and localization of projectiles or other components of ammunition, visualization of secondary missiles), sharp force injuries (air embolism, identification of the weapon) and motor vehicle related deaths. The method is also helpful for complex injury evaluation in abused victims or in persons where abuse is suspected. Finally, X-ray imaging still remains the gold standard method for identification of unknown deceased. With time modern imaging methods, especially computed tomography and magnetic resonance imaging, are more and more applied in forensic medicine. Their application extends possibilities of the visualization the bony structures toward a more detailed imaging of soft tissues and internal organs. The application of modern imaging methods in postmortem body investigation is known as digital or virtual autopsy. At present digital postmortem imaging is considered as a bloodless alternative to the conventional autopsy.

  15. Towards hard X-ray imaging at GHz frame rate

    CERN Document Server

    Wang, Zhehui; Kapustinsky, J S; Kwiatkowski, K; Luo, S -N

    2012-01-01

    Gigahertz (GHz) imaging using hard X-rays ($\\gtrsim$ 10 keV) can be useful to high-temperature plasma experiments, as well as research using coherent photons from synchrotron radiation and X-ray free electron lasers. GHz framing rate can be achieved by using multiple cameras through multiplexing. The advantages and trade-offs of single-photon detection mode, when no more than one X-ray photon is detected per pixel, are given. Two possible paths towards X-ray imaging at GHz frame rates using a single camera are a.) Avalanche photodiode arrays of high-Z materials and b.) Microchannel plate photomultipliers in conjunction with materials with large indices of refraction.

  16. Towards hard x-ray imaging at GHz frame rate

    Energy Technology Data Exchange (ETDEWEB)

    Wang Zhehui; Morris, C. L.; Kapustinsky, J. S.; Kwiatkowski, K.; Luo, S.-N. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2012-10-15

    Gigahertz (GHz) imaging using hard x-rays ( Greater-Than-Or-Equivalent-To 10 keV) can be useful to high-temperature plasma experiments, as well as research and applications using coherent photons from synchrotron radiation and x-ray free electron lasers. GHz framing rate can be achieved by using multiple cameras through multiplexing. The advantages and trade-offs of single-photon detection mode, when no more than one x-ray photon is detected per pixel, are given. Two possible paths towards x-ray imaging at GHz frame rates using a single camera are: (a) avalanche photodiode arrays of high-Z materials and (b) microchannel plate photomultipliers in conjunction with materials with large indices of refraction.

  17. Spectroscopic imaging, diffraction, and holography with x-ray photoemission

    Energy Technology Data Exchange (ETDEWEB)

    1992-02-01

    X-ray probes are capable of determining the spatial structure of an atom in a specific chemical state, over length scales from about a micron all the way down to atomic resolution. Examples of these probes include photoemission microscopy, energy-dependent photoemission diffraction, photoelectron holography, and X-ray absorption microspectroscopy. Although the method of image formation, chemical-state sensitivity, and length scales can be very different, these X-ray techniques share a common goal of combining a capability for structure determination with chemical-state specificity. This workshop will address recent advances in holographic, diffraction, and direct imaging techniques using X-ray photoemission on both theoretical and experimental fronts. A particular emphasis will be on novel structure determinations with atomic resolution using photoelectrons.

  18. Towards hard X-ray imaging at GHz frame rate

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhehui [Los Alamos National Laboratory; Morris, Christopher [Los Alamos National Laboratory; Luo, Shengnian [Los Alamos National Laboratory; Kwiatkowski, Kris K. [Los Alamos National Laboratory; Kapustinsky, Jon S. [Los Alamos National Laboratory

    2012-05-02

    Gigahertz (GHz) imaging using hard X-rays ({approx}> 10 keV) can be useful to high-temperature plasma experiments, as well as research using coherent photons from synchrotron radiation and X-ray free electron lasers. GHz framing rate can be achieved by using multiple cameras through multiplexing. The advantages and trade-offs of single-photon detection mode, when no more than one X-ray photon is detected per pixel, are given. Two possible paths towards X-ray imaging at GHz frame rates using a single camera are (a) Avalanche photodiode arrays of high-Z materials and (b) Microchannel plate photomultipliers in conjunction with materials with large indices of refraction.

  19. Towards hard x-ray imaging at GHz frame rate.

    Science.gov (United States)

    Wang, Zhehui; Morris, C L; Kapustinsky, J S; Kwiatkowski, K; Luo, S-N

    2012-10-01

    Gigahertz (GHz) imaging using hard x-rays (> or approximately equal to 10 keV) can be useful to high-temperature plasma experiments, as well as research and applications using coherent photons from synchrotron radiation and x-ray free electron lasers. GHz framing rate can be achieved by using multiple cameras through multiplexing. The advantages and trade-offs of single-photon detection mode, when no more than one x-ray photon is detected per pixel, are given. Two possible paths towards x-ray imaging at GHz frame rates using a single camera are: (a) avalanche photodiode arrays of high-Z materials and (b) microchannel plate photomultipliers in conjunction with materials with large indices of refraction.

  20. X-ray imaging detectors for synchrotron and XFEL sources

    Directory of Open Access Journals (Sweden)

    Takaki Hatsui

    2015-05-01

    Full Text Available Current trends for X-ray imaging detectors based on hybrid and monolithic detector technologies are reviewed. Hybrid detectors with photon-counting pixels have proven to be very powerful tools at synchrotrons. Recent developments continue to improve their performance, especially for higher spatial resolution at higher count rates with higher frame rates. Recent developments for X-ray free-electron laser (XFEL experiments provide high-frame-rate integrating detectors with both high sensitivity and high peak signal. Similar performance improvements are sought in monolithic detectors. The monolithic approach also offers a lower noise floor, which is required for the detection of soft X-ray photons. The link between technology development and detector performance is described briefly in the context of potential future capabilities for X-ray imaging detectors.

  1. X-ray imaging detectors for synchrotron and XFEL sources.

    Science.gov (United States)

    Hatsui, Takaki; Graafsma, Heinz

    2015-05-01

    Current trends for X-ray imaging detectors based on hybrid and monolithic detector technologies are reviewed. Hybrid detectors with photon-counting pixels have proven to be very powerful tools at synchrotrons. Recent developments continue to improve their performance, especially for higher spatial resolution at higher count rates with higher frame rates. Recent developments for X-ray free-electron laser (XFEL) experiments provide high-frame-rate integrating detectors with both high sensitivity and high peak signal. Similar performance improvements are sought in monolithic detectors. The monolithic approach also offers a lower noise floor, which is required for the detection of soft X-ray photons. The link between technology development and detector performance is described briefly in the context of potential future capabilities for X-ray imaging detectors.

  2. Dilation x-ray imager a new∕faster gated x-ray imager for the NIF.

    Science.gov (United States)

    Nagel, S R; Hilsabeck, T J; Bell, P M; Bradley, D K; Ayers, M J; Barrios, M A; Felker, B; Smith, R F; Collins, G W; Jones, O S; Kilkenny, J D; Chung, T; Piston, K; Raman, K S; Sammuli, B; Hares, J D; Dymoke-Bradshaw, A K L

    2012-10-01

    As the yield on implosion shots increases it is expected that the peak x-ray emission reduces to a duration with a FWHM as short as 20 ps for ∼7 × 10(18) neutron yield. However, the temporal resolution of currently used gated x-ray imagers on the NIF is 40-100 ps. We discuss the benefits of the higher temporal resolution for the NIF and present performance measurements for dilation x-ray imager, which utilizes pulse-dilation technology [T. J. Hilsabeck et al., Rev. Sci. Instrum. 81, 10E317 (2010)] to achieve x-ray imaging with temporal gate times below 10 ps. The measurements were conducted using the COMET laser, which is part of the Jupiter Laser Facility at the Lawrence Livermore National Laboratory.

  3. Frontiers in imaging magnetism with polarized x-rays

    Directory of Open Access Journals (Sweden)

    Peter eFischer

    2015-01-01

    Full Text Available Although magnetic imaging with polarized x-rays is a rather young scientific discipline, the various types of established x-ray microscopes have already taken an important role in state-of-the-art characterization of the properties and behavior of spin textures in advanced materials. The opportunities ahead will be to obtain in a unique way indispensable multidimensional information of the structure, dynamics and composition of scientifically interesting and technologically relevant magnetic materials.

  4. X-ray imaging detectors for synchrotron and XFEL sources

    OpenAIRE

    Takaki Hatsui; Heinz Graafsma

    2015-01-01

    Current trends for X-ray imaging detectors based on hybrid and monolithic detector technologies are reviewed. Hybrid detectors with photon-counting pixels have proven to be very powerful tools at synchrotrons. Recent developments continue to improve their performance, especially for higher spatial resolution at higher count rates with higher frame rates. Recent developments for X-ray free-electron laser (XFEL) experiments provide high-frame-rate integrating detectors with both high sensitivit...

  5. Fourier-Transform Ghost Imaging with Hard X Rays

    Science.gov (United States)

    Yu, Hong; Lu, Ronghua; Han, Shensheng; Xie, Honglan; Du, Guohao; Xiao, Tiqiao; Zhu, Daming

    2016-09-01

    Knowledge gained through x-ray crystallography fostered structural determination of materials and greatly facilitated the development of modern science and technology in the past century. However, it is only applied to crystalline structures and cannot resolve noncrystalline materials. Here we demonstrate a novel lensless Fourier-transform ghost imaging method with pseudothermal hard x rays that extends x-ray crystallography to noncrystalline samples. By measuring the second-order intensity correlation function of the light, Fourier-transform diffraction pattern of a complex amplitude sample is achieved at the Fresnel region in our experiment and the amplitude and phase distributions of the sample in the spatial domain are retrieved successfully. For the first time, ghost imaging is experimentally realized with x rays. Since a highly coherent x-ray source is not required, the method can be implemented with laboratory x-ray sources and it also provides a potential solution for lensless diffraction imaging with fermions, such as neutrons and electrons where intensive coherent sources usually are not available.

  6. Fourier-transform Ghost Imaging with Hard X-rays

    CERN Document Server

    Yu, Hong; Han, Shensheng; Xie, Honglan; Du, Guohao; Xiao, Tiqiao; Zhu, Daming

    2016-01-01

    Knowledge gained through X-ray crystallography fostered structural determination of materials and greatly facilitated the development of modern science and technology in the past century. Atomic details of sample structures is achievable by X-ray crystallography, however, it is only applied to crystalline structures. Imaging techniques based on X-ray coherent diffraction or zone plates are capable of resolving the internal structure of non-crystalline materials at nanoscales, but it is still a challenge to achieve atomic resolution. Here we demonstrate a novel lensless Fourier-transform ghost imaging method with pseudo-thermal hard X-rays by measuring the second-order intensity correlation function of the light. We show that high resolution Fourier-transform diffraction pattern of a complex structure can be achieved at Fresnel region, and the amplitude and phase distributions of a sample in spatial domain can be retrieved successfully. The method of lensless X-ray Fourier-transform ghost imaging extends X-ray...

  7. Refraction contrast in X-ray imaging

    CERN Document Server

    Keyrilaeinen, J; Suortti, P

    2002-01-01

    A two-crystal diffractometer in the non-dispersive configuration is used for measurement of the effects of refraction in weakly absorbing test objects. Characteristic K alpha sub 1 radiation from a fine-focus X-ray tube with Mo anode is used. The probing beam is about 70 mu m wide and 3 mm high. The sample is placed between the monochromator and analyzer, and it is scanned through the beam. The analyzer is tuned to reflect at the low-angle slope, at the top, or at the high-angle slope of the rocking curve, when the sample is not in the beam. Refraction changes the angle of incidence on the analyzer causing changes in intensity. The observed intensity distributions are exactly reproduced by a calculation, where only the effects of refraction are included. The effects of in-beam interference are negligible or very small, which is also verified by changing the distance between the object and the detector.

  8. Optimal material discrimination using spectral x-ray imaging.

    Science.gov (United States)

    Nik, S J; Meyer, J; Watts, R

    2011-09-21

    Spectral x-ray imaging using novel photon counting x-ray detectors (PCDs) with energy resolving abilities is capable of providing energy-selective images. PCDs have energy thresholds, enabling the classification of photons into multiple energy bins. The extra energy information provided may allow materials such as iodine and calcium, or water and fat to be distinguishable. The information content of spectral x-ray images, however, depends on how the photons are grouped together. In this work, we present a model to optimize energy windows for maximum material discrimination. Multivariate statistics allows the confidence region of the correlated uncertainties to be mapped in the thickness space. Minimization of the uncertainties enables optimization of energy windows. Applications related to small animal imaging and breast imaging are considered.

  9. Elemental x-ray imaging using Zernike phase contrast

    Science.gov (United States)

    Shao, Qi-Gang; Chen, Jian; Wali, Faiz; Bao, Yuan; Wang, Zhi-Li; Zhu, Pei-Ping; Tian, Yang-Chao; Gao, Kun

    2016-10-01

    We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images are subtracted to obtain the target element: one is at the absorption edge of the target element and the other is near the absorption edge. The x-ray exposure required by this method is expected to be significantly lower than that of conventional absorption-based x-ray elemental imaging methods. Numerical calculations confirm the advantages of this highly efficient imaging method. Project supported by the National Basic Research Program of China (Grant No. 2012CB825801) and the National Natural Science Foundation of China (Grant Nos. 11505188, and 11305173).

  10. Energy weighted x-ray dark-field imaging

    CERN Document Server

    Pelzer, Georg; Anton, Gisela; Bayer, Florian; Horn, Florian; Kraus, Manuel; Rieger, Jens; Ritter, Andre; Wandner, Johannes; Weber, Thomas; Fauler, Alex; Fiederle, Michael; Wong, Winnie S; Campbell, Michael; Meiser, Jan; Meyer, Pascal; Mohr, Jürgen; Michel, Thilo

    2014-01-01

    The dark-field image obtained in grating-based x-ray phase-contrast imaging can provide information about the objects' microstructures on a scale smaller than the pixel size even with low geometric magnification. In this publication we demonstrate that the dark-field image quality can be enhanced with an energy-resolving pixel detector. Energy-resolved x-ray dark-field images were acquired with a 16-energy-channel photon-counting pixel detector with a 1 mm thick CdTe sensor in a Talbot-Lau x-ray interferometer. A method for contrast-noise-ratio (CNR) enhancement is proposed and validated experimentally. In measurements, a CNR improvement by a factor of 1.14 was obtained. This is equivalent to a possible radiation dose reduction of 23%.

  11. Ancient administrative handwritten documents: X-ray analysis and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Albertin, F., E-mail: fauzia.albertin@epfl.ch [Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne (Switzerland); Astolfo, A. [Paul Scherrer Institut (PSI), Villigen (Switzerland); Stampanoni, M. [Paul Scherrer Institut (PSI), Villigen (Switzerland); ETHZ, Zürich (Switzerland); Peccenini, Eva [University of Ferrara (Italy); Technopole of Ferrara (Italy); Hwu, Y. [Academia Sinica, Taipei, Taiwan (China); Kaplan, F. [Ecole Polytechnique Fédérale de Lausanne (EPFL) (Switzerland); Margaritondo, G. [Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne (Switzerland)

    2015-01-30

    The heavy-element content of ink in ancient administrative documents makes it possible to detect the characters with different synchrotron imaging techniques, based on attenuation or refraction. This is the first step in the direction of non-interactive virtual X-ray reading. Handwritten characters in administrative antique documents from three centuries have been detected using different synchrotron X-ray imaging techniques. Heavy elements in ancient inks, present even for everyday administrative manuscripts as shown by X-ray fluorescence spectra, produce attenuation contrast. In most cases the image quality is good enough for tomography reconstruction in view of future applications to virtual page-by-page ‘reading’. When attenuation is too low, differential phase contrast imaging can reveal the characters from refractive index effects. The results are potentially important for new information harvesting strategies, for example from the huge Archivio di Stato collection, objective of the Venice Time Machine project.

  12. Imaging with parabolic refractive X-ray lenses

    OpenAIRE

    Benner, Boris

    2005-01-01

    When Wilhelm C. Roentgen discovered the x-ray radiation in 1895, he made use of its large penetration depth in matter to create projections of different opaque objects, and also of bones inside the body. The imaging of dense matter inside the body has rapidly found wide use in medicine and is nowadays an important diagnostic tool. But imaging with x-ray radiation is also used in research and technology. The development of 3 dimensional imaging by means of tomographic reconstruction in the lat...

  13. XIPE: the x-ray imaging polarimetry explorer

    Science.gov (United States)

    Soffitta, P.; Bellazzini, R.; Bozzo, E.; Burwitz, V.; Castro-Tirado, A.; Costa, E.; Courvoisier, T.; Feng, H.; Gburek, S.; Goosmann, R.; Karas, V.; Matt, G.; Muleri, F.; Nandra, K.; Pearce, M.; Poutanen, J.; Reglero, V.; Sabau Maria, D.; Santangelo, A.; Tagliaferri, G.; Tenzer, C.; Vink, J.; Weisskopf, M. C.; Zane, S.; Agudo, I.; Antonelli, A.; Attina, P.; Baldini, L.; Bykov, A.; Carpentiero, R.; Cavazzuti, E.; Churazov, E.; Del Monte, E.; De Martino, D.; Donnarumma, I.; Doroshenko, V.; Evangelista, Y.; Ferreira, I.; Gallo, E.; Grosso, N.; Kaaret, P.; Kuulkers, E.; Laranaga, J.; Latronico, L.; Lumb, D. H.; Macian, J.; Malzac, J.; Marin, F.; Massaro, E.; Minuti, M.; Mundell, C.; Ness, J. U.; Oosterbroek, T.; Paltani, S.; Pareschi, G.; Perna, R.; Petrucci, P.-O.; Pinazo, H. B.; Pinchera, M.; Rodriguez, J. P.; Roncadelli, M.; Santovincenzo, A.; Sazonov, S.; Sgro, C.; Spiga, D.; Svoboda, J.; Theobald, C.; Theodorou, T.; Turolla, R.; Wilhelmi de Ona, E.; Winter, B.; Akbar, A. M.; Allan, H.; Aloisio, R.; Altamirano, D.; Amati, L.; Amato, E.; Angelakis, E.; Arezu, J.; Atteia, J.-L.; Axelsson, M.; Bachetti, M.; Ballo, L.; Balman, S.; Bandiera, R.; Barcons, X.; Basso, S.; Baykal, A.; Becker, W.; Behar, E.; Beheshtipour, B.; Belmont, R.; Berger, E.; Bernardini, F.; Bianchi, S.; Bisnovatyi-Kogan, G.; Blasi, P.; Blay, P.; Bodaghee, A.; Boer, M.; Boettcher, M.; Bogdanov, S.; Bombaci, I.; Bonino, R.; Braga, J.; Brandt, W.; Brez, A.; Bucciantini, N.; Burderi, L.; Caiazzo, I.; Campana, R.

    2016-07-01

    XIPE, the X-ray Imaging Polarimetry Explorer, is a mission dedicated to X-ray Astronomy. At the time of writing XIPE is in a competitive phase A as fourth medium size mission of ESA (M4). It promises to reopen the polarimetry window in high energy Astrophysics after more than 4 decades thanks to a detector that efficiently exploits the photoelectric effect and to X-ray optics with large effective area. XIPE uniqueness is time-spectrally-spatially- resolved X-ray polarimetry as a breakthrough in high energy astrophysics and fundamental physics. Indeed the payload consists of three Gas Pixel Detectors at the focus of three X-ray optics with a total effective area larger than one XMM mirror but with a low weight. The payload is compatible with the fairing of the Vega launcher. XIPE is designed as an observatory for X-ray astronomers with 75 % of the time dedicated to a Guest Observer competitive program and it is organized as a consortium across Europe with main contributions from Italy, Germany, Spain, United Kingdom, Poland, Sweden.

  14. Chest X-ray imaging of patients with SARS

    Institute of Scientific and Technical Information of China (English)

    陆普选; 周伯平; 陈心春; 袁明远; 龚小龙; 杨根东; 刘锦清; 袁本通; 郑广平; 杨桂林; 王火生

    2003-01-01

    Objective To investigate the chest X-ray manifestations of SARS cases.Methods A retrospective study was conducted among 52 clinically confirmed SARS patients from February 9 to May 10, 2003. Chest X-ray scanning was performed at a interval of 1-3 days according to the requirements. The manifestations and special features of SARS in X-ray were analyzed. Results Small or large patchy shadows with intensive density in both lungs were observed in 31 cases, ground-glass like opacification in 16, small patchy shadows in one lung lobe or one lung segment in 18, nodular shadows in one lung segment in 1, and increased lung marking in lung interstitial tissues in 2. Rapidly changing consolidations revealed in chest X-ray images were found to be associated with SARS infections, and they were not affected by treatment with antibiotics.Conclusion Chest X-ray provides a sensitive and specific method for the diagnosis and treatment of SARS, and those present with symptoms and signs should undergo chest X-ray scanning every 1-3 days.

  15. The CZT X-ray Imager on AXO

    Science.gov (United States)

    Budtz-Jørgensen, C.; Kuvvetli, I.; Westergaard, N. J.; Jonasson, P.; Reglero, V.; Eyles, C.; Neubert, T.

    2001-03-01

    DSRI has initiated a development program of CZT X-ray and gamma ray detectors employing strip readout techniques. A dramatic improvement of the energy response was found operating the detectors as so-called drift detectors. For the electronic readout, modern ASIC chips were investigated. Modular design and the low power electronics will make large area detectors using the drift strip method feasible. The performance of a prototype CZT system will be presented and discussed. One such detector system has been proposed for future space missions: The X-Ray Imager (XRI) on the Atmospheric X-ray Observatory (AXO), which is a mission proposed to the Danish Small Satellite Program and is dedicated to observations of X-ray generating processes in the Earth's atmosphere. Of special interest will be simultaneous optical and X-ray observations of sprites that are flashes appearing directly above an active thunderstorm system. Additional objective is a detailed mapping of the auroral X-ray and optical emission. XRI comprises a coded mask and a 20 cm × 40 cm CZT detector array covering an energy range from 5 to 200 keV.

  16. Synchrotron x-ray ultrafast x-ray imaging on dynamic multiphase flow studies

    Science.gov (United States)

    Wang, Yujie; Fezzaa, Kamel; Wang, Jin; Im, Kyoung-Su

    2007-03-01

    To overcome the long-exposure time of x-ray imaging for liquid systems. In the past year, we have developed the first ultrafast white-beam synchrotron x-ray phase-contrast imaging technique in the world. With its unprecedented temporal (0.5 μs) and spatial resolutions (1 μm), this new technique has already shown great promises in the study of complex fluid mechanical systems. It can probe complex surface morphology and transient dynamics of these interfaces of fluid mechanical systems without the nuisance of multiple scattering. This technique is a big step forward in comparison to millisecond-temporal and micrometer-spatial imaging resolutions normally achieved at various synchrotron sources. With the development of this new technique, we can already carry out research in fluid mechanical systems in competition with world-leading research groups. Our study of the primary breakup process of a coaxial air-assisted liquid jet revealed that the dynamics is dominated by a ``liquid membrane breakup'' process instead of a simple ``ligament mediated breakup'' process owing to our far superior temporal and spatial resolutions. This observation will naturally lead to a cascade idea for the unified treatment of liquid jets, droplets, and liquid membranes breakup mechanism.

  17. Spinal X-ray image analysis in scoliosis

    NARCIS (Netherlands)

    Sardjono, Tri Arief

    2007-01-01

    In this thesis new image analysis methods are discussed to determine the curvature of scoliotic patients characterised by the Cobb angle and to enhance the vertebral parts based on features from a frontal X-ray image. Chapter 1 provides some background information on scoliosis, how to diagnose it, t

  18. The High Energy X-ray Imager Technology (HEXITEC) for Solar Hard X-ray Observations

    Science.gov (United States)

    Christe, Steven; Shih, Albert Y.; Gaskin, Jessica; Wilson-Hodge, Colleen; Seller, Paul; Wilson, Matthew

    2015-04-01

    High angular resolution HXR optics require detectors with a large number of fine pixels in order to adequately sample the telescope point spread function (PSF) over the entire field of view. Excessively over-sampling the PSF will increase readout noise and require more processing with no appreciable increase in image quality. An appropriate level of over-sampling is to have 3 pixels within the HPD. For current high resolution X-ray mirrors, the HPD is about 25 arcsec. Over a 6-m focal length this converts to 750 µm, the optimum pixel size is around 250 µm. Annother requirement are that the detectors must also have high efficiency in the HXR region, good energy resolution, low background, low power requirements, and low sensitivity to radiation damage. For solar observations, the ability to handle high counting rates is also extremely desirable. The Rutherford Appleton Laboratory (RAL) in the UK has been developing the electronics for such a detector. Dubbed HEXITEC, for High Energy X-Ray Imaging Technology, this Application Specific Integrated Circuit (ASIC), can be bonded to 1- or 2- mm-thick Cadmium Telluride (CdTe) or Cadmium-Zinc-Telluride (CZT), to create a fine (250 µm pitch) HXR detector. The NASA Marshall Space Flight CenterMSFC and the Goddard Space Flight Center (GSFC) has been working with RAL over the past few years to develop these detectors to be used with HXR focusing telescopes. We present on recent results and capabilities as applied to solar observations.

  19. [Lithium fluoride: not only dosimetry, but also X ray imaging?].

    Science.gov (United States)

    Bonfigli, F; Campurra, G; Montereali, R M; Vincenti, M A

    2011-01-01

    Lithium fluoride is a well known material used for dosimetry. In the last years it was proposed and tested also as imaging detector for X-ray microscopy. Optical microscopy represents the oldest and most used imaging technique for medicine and cell biology investigations; later other imaging techniques, including electron microscopy, were introduced. The recent technological developments in the soft X-ray field, concerning sources, optics and detectors, have been increased the interest of physicians and biologists for X-ray microscopy, mainly to obtain in vivo imaging of cells. An innovative imaging detector has been proposed and tested by researchers of C.R. ENEA Frascati, as handy, versatile and compact plate for soft X-ray imaging with very high spatial resolution, wide dynamic range, large field of view and easy to read by an optical microscope. Scientific and technological applications can be foreseen in several fields, as nanotechnologies, materials, photonics, life science and microscopy (including cell imaging, also in vivo).

  20. The Imaging X-Ray Polarimetry Explorer (IXPE)

    Science.gov (United States)

    Weisskopf, Martin C.; Ramsey, Brian; O’Dell, Stephen; Tennant, Allyn; Elsner, Ronald; Soffita, Paolo; Bellazzini, Ronaldo; Costa, Enrico; Kolodziejczak, Jeffery; Kaspi, Victoria; Mulieri, Fabio; Marshall, Herman; Matt, Giorgio; Romani, Roger

    2016-01-01

    The Imaging X-ray Polarimetry Explorer (IXPE) is an exciting international collaboration for a scientific mission that dramatically brings together the unique talents of the partners to expand observation space by simultaneously adding polarization measurements to the array of source properties currently measured (energy, time, and location). IXPE uniquely brings to the table polarimetric imaging. IXPE will thus open new dimensions for understanding how X-ray emission is produced in astrophysical objects, especially systems under extreme physical conditions-such as neutron stars and black holes. Polarization singularly probes physical anisotropies-ordered magnetic fields, aspheric matter distributions, or general relativistic coupling to black-hole spin-that are not otherwise measurable. Hence, IXPE complements all other investigations in high-energy astrophysics by adding important and relatively unexplored information to the parameter space for studying cosmic X-ray sources and processes, as well as for using extreme astrophysical environments as laboratories for fundamental physics.

  1. Multimodal X-ray Imaging of Hierarchical Materials

    DEFF Research Database (Denmark)

    Birkbak, Mie Elholm

    2017-01-01

    of possible contrast mechanism, X-rays serves as an optimal probe for describing dense, hierarchical materials. The work presented in this thesis describes several hierarchical systems using a wide palette of X-ray imaging techniques. Previously undescribed features were revealed in bone, the tusk...... changes in all parameters as a function of the distance to the growth zone. Methods for describing the 3D elemental distribution in dense materials were developed and reveal the internal distribution of elements in bone on the sub-cellular scale. Finally, diffraction scattering computed tomography...... be followed during is situ conditions such as during applied load. The research presented in the thesis demonstrates how modern X-ray imaging techniques can be used to produce new knowledge about hierarchical materials not otherwise accessible. The 3D nature of the techniques not only provides crucial...

  2. Imaging X-ray Thomson Scattering Spectrometer Design and Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Gamboa, E.J. [University of Michigan; Huntington, C.M. [University of Michigan; Trantham, M.R. [University of Michigan; Keiter, P.A [University of Michigan; Drake, R.P. [University of Michigan; Montgomery, David [Los Alamos National Laboratory; Benage, John F. [Los Alamos National Laboratory; Letzring, Samuel A. [Los Alamos National Laboratory

    2012-05-04

    In many laboratory astrophysics experiments, intense laser irradiation creates novel material conditions with large, one-dimensional gradients in the temperature, density, and ionization state. X-ray Thomson scattering is a powerful technique for measuring these plasma parameters. However, the scattered signal has previously been measured with little or no spatial resolution, which limits the ability to diagnose inhomogeneous plasmas. We report on the development of a new imaging x-ray Thomson spectrometer (IXTS) for the Omega laser facility. The diffraction of x-rays from a toroidally-curved crystal creates high-resolution images that are spatially resolved along a one-dimensional profile while spectrally dispersing the radiation. This focusing geometry allows for high brightness while localizing noise sources and improving the linearity of the dispersion. Preliminary results are presented from a scattering experiment that used the IXTS to measure the temperature profile of a shocked carbon foam.

  3. A new photoelectron imager for X-ray astronomical polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    La Monaca, A. [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Costa, E; Soffitta, P.; Di Persio, G.; Manzan, M.; Martino, B.; Patria, G. [CNR, Rome (Italy). Ist. di Astrofisica Spaziale; Cappuccio, G. [CNR, Monterotondo (Italy). Ist. di Strutturistica Chimica]|[INFN, Laboratori Nazionali di Frascati, Rome (Italy); Zema, N. [CNR, Rome (Italy). Ist. di Struttura della Materia

    1998-04-01

    A new photoelectron imager for X-ray astronomical polarimetry (PIAP) has been developed and tested at the Frascati (Rome, Italy) National Laboratories of National Institute of Nuclear Physics (LNF-INFN). A charge-coupled device (CCD) is placed on one of the two conjugate foci of a Cassegrain reflective optics onto which are focused UV photons emitted by means of gas scintillation. This X-ray detector has been built to image the angular distribution of the photoelectron tracks, whose anisotropy measures the X-ray polarization. First tests, performed by using mixtures based on argon gas and benzene at low pressure, show events which are candidate tracks of photoelectrons and Auger electrons produced by a {sup 55}Fe source.

  4. Hard x-ray imaging polarimeter for PolariS

    Science.gov (United States)

    Hayashida, Kiyoshi; Kim, Juyong; Sadamoto, Masaaki; Yoshinaga, Keigo; Gunji, Shuichi; Mihara, Tatehiro; Kishimoto, Yuji; Kubo, Hidetoshi; Mizuno, Tsunefumi; Takahashi, Hiromitsu; Dotani, Tadayasu; Yonetoku, Daisuke; Nakamori, Takeshi; Yoneyama, Tomokage; Ikeyama, Yuki; Kamitsukasa, Fumiyoshi

    2016-07-01

    Hard X-ray imaging polarimeters are developed for the X-ray γ-ray polaeimtery satellite PolariS. The imaging polarimter is scattering type, in which anisotropy in the direction of Compton scattering is employed to measure the hard X-ray (10-80 keV) polarization, and is installed on the focal planes of hard X-ray telescopes. We have updated the design of the model so as to cover larger solid angles of scattering direction. We also examine the event selection algorithm to optimize the detection efficiency of recoiled electrons in plastic scintillators. We succeed in improving the efficiency by factor of about 3-4 from the previous algorithm and criteria for 18-30 keV incidence. For 23 keV X-ray incidence, the recoiled electron energy is about 1 keV. We measured the efficiency to detect recoiled electrons in this case, and found about half of the theoretical limit. The improvement in this efficiency directly leads to that in the detection efficiency. In other words, however, there is still a room for improvement. We examine various process in the detector, and estimate the major loss is primarily that of scintillation light in a plastic scintillator pillar with a very small cross section (2.68mm squared) and a long length (40mm). Nevertheless, the current model provides the MDP of 6% for 10mCrab sources, which are the targets of PolariS.

  5. Simultaneous dual-energy X-ray stereo imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mokso, Rajmund, E-mail: rajmund.mokso@psi.ch [Paul Scherrer Institute, Swiss Light Source, CH 5232 Villigen (Switzerland); Oberta, Peter [Institute of Physics of the Academy of Sciences of the Czech Republic, v.v.i., Na Slovance 1999/2, Praha 8 (Czech Republic); Rigaku Innovative Technologies Europe s.r.o., Novodvorska 994, Praha 4 (Czech Republic)

    2015-06-26

    A Laue–Bragg geometry is introduced for splitting an X-ray beam and tuning each of the two branches to selected wavelength. Stereoscopic and dual-energy imaging was performed with this system. Dual-energy or K-edge imaging is used to enhance contrast between two or more materials in an object and is routinely realised by acquiring two separate X-ray images each at different X-ray wavelength. On a broadband synchrotron source an imaging system to acquire the two images simultaneously was realised. The single-shot approach allows dual-energy and stereo imaging to be applied to dynamic systems. Using a Laue–Bragg crystal splitting scheme, the X-ray beam was split into two and the two beam branches could be easily tuned to either the same or to two different wavelengths. Due to the crystals’ mutual position, the two beam branches intercept each other under a non-zero angle and create a stereoscopic setup.

  6. Submicron hard X-ray fluorescence imaging of synthetic elements

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Mark P., E-mail: mjensen@anl.gov [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Aryal, Baikuntha P. [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Department of Chemistry, University of Chicago, Chicago, IL 60637 (United States); Gorman-Lewis, Drew [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Paunesku, Tatjana [Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 (United States); Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 (United States); Lai, Barry; Vogt, Stefan [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439 (United States); Woloschak, Gayle E. [Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 (United States); Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 (United States)

    2012-04-13

    Highlights: Black-Right-Pointing-Pointer Actinide elements are mapped with L-edge X-rays and better than 400 nm resolution. Black-Right-Pointing-Pointer A typical detection limit was 2.9 Multiplication-Sign 10{sup -20} moles Pu {mu}m{sup -2}. Black-Right-Pointing-Pointer XANES measurements provide chemical information in 0.1 {mu}m{sup 2} spots. Black-Right-Pointing-Pointer Selection of materials for encapsulation is important for avoiding interferences. - Abstract: Synchrotron-based X-ray fluorescence microscopy (XFM) using hard X-rays focused into sub-micron spots is a powerful technique for elemental quantification and mapping, as well as microspectroscopic measurements such as {mu}-XANES (X-ray absorption near edge structure). We have used XFM to image and simultaneously quantify the transuranic element plutonium at the L{sub 3} or L{sub 2}-edge as well as Th and lighter biologically essential elements in individual rat pheochromocytoma (PC12) cells after exposure to the long-lived plutonium isotope {sup 242}Pu. Elemental maps demonstrate that plutonium localizes principally in the cytoplasm of the cells and avoids the cell nucleus, which is marked by the highest concentrations of phosphorus and zinc, under the conditions of our experiments. The minimum detection limit under typical acquisition conditions with an incident X-ray energy of 18 keV for an average 202 {mu}m{sup 2} cell is 1.4 fg Pu or 2.9 Multiplication-Sign 10{sup -20} moles Pu {mu}m{sup -2}, which is similar to the detection limit of K-edge XFM of transition metals at 10 keV. Copper electron microscopy grids were used to avoid interference from gold X-ray emissions, but traces of strontium present in naturally occurring calcium can still interfere with plutonium detection using its L{sub {alpha}} X-ray emission.

  7. Automatic Tongue Tracking in X-Ray Images

    Institute of Scientific and Technical Information of China (English)

    LUO Changwei; LI Rui; YU Lingyun; YU Jun; WANG Zengfu

    2015-01-01

    X-ray imaging is an eff ective technique to obtain the continuous motions of the vocal tract during speech, and Active appearance model (AAM) is a useful tool to analyze the X-ray images. However, for the task of tongue tracking in X-ray images, the accuracy of AAM fit-ting is insufficient. AAM aims to minimize the residual er-ror between the model appearance and the input image. It often fails to accurately converge to the true landmarks. To improve the tracking accuracy, we propose a fitting method by combining Constrained local model (CLM) into AAM. In our method, we first combine the objective functions of AAM and CLM into a single ob jective function. Then, we pro ject out the texture variation and derive a gradi-ent based method to optimize the objective function. Our method eff ectively incorporates not only the shape prior and global texture, but also local texture around each land-mark. Experiments demonstrate that the proposed method significantly reduces the fitting error. We also show that re-alistic 3D tongue animation can be created by using tongue tracking results of the X-ray images.

  8. Phase contrast imaging with coherent high energy X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Snigireva, I. [ESRF, Grenoble (France)

    1997-02-01

    X-ray imaging concern high energy domain (>6 keV) like a contact radiography, projection microscopy and tomography is used for many years to discern the features of the internal structure non destructively in material science, medicine and biology. In so doing the main contrast formation is absorption that makes some limitations for imaging of the light density materials and what is more the resolution of these techniques is not better than 10-100 {mu}m. It was turned out that there is now way in which to overcome 1{mu}m or even sub-{mu}m resolution limit except phase contrast imaging. It is well known in optics that the phase contrast is realised when interference between reference wave front and transmitted through the sample take place. Examples of this imaging are: phase contrast microscopy suggested by Zernike and Gabor (in-line) holography. Both of this techniques: phase contrast x-ray microscopy and holography are successfully progressing now in soft x-ray region. For imaging in the hard X-rays to enhance the contrast and to be able to resolve phase variations across the beam the high degree of the time and more importantly spatial coherence is needed. Because of this it was reasonable that the perfect crystal optics was involved like Bonse-Hart interferometry, double-crystal and even triple-crystal set-up using Laue and Bragg geometry with asymmetrically cut crystals.

  9. X-ray phase contrast imaging at MAMI

    Energy Technology Data Exchange (ETDEWEB)

    El-Ghazaly, M.; Backe, H.; Lauth, W.; Kube, G.; Kunz, P.; Sharafutdinov, A.; Weber, T. [Universitaet Mainz, Institut fuer Kernphysik, Mainz (Germany)

    2006-05-15

    Experiments have been performed to explore the potential of the low emittance 855 MeV electron beam of the Mainz Microtron MAMI for imaging with coherent X-rays. Transition radiation from a micro-focused electron beam traversing a foil stack served as X-ray source with good transverse coherence. Refraction contrast radiographs of low absorbing materials, in particular polymer strings with diameters between 30 and 450 {mu}m, were taken with a polychromatic transition radiation X-ray source with a spectral distribution in the energy range between 8 and about 40 keV. The electron beam spot size had standard deviation {sigma}{sub h}=(8.6{+-}0.1) {mu}m in the horizontal and {sigma}{sub v}=(7.5{+-}0.1) {mu}m in the vertical direction. X-ray films were used as detectors. The source-to-detector distance amounted to 11.4 m. The objects were placed in a distance of up to 6m from the X-ray film. Holograms of strings were taken with a beam spot size {sigma}{sub v}=(0.50{+-}0.05) {mu}m in vertical direction, and a monochromatic X-ray beam of 6keV energy. A good longitudinal coherence has been obtained by the (111) reflection of a flat silicon single crystal in Bragg geometry. It has been demonstrated that a direct exposure CCD chip with a pixel size of 13 x 13 {mu}m{sup 2} provides a highly efficient on-line detector. Contrast images can easily be generated with a complete elimination of all parasitic background. The on-line capability allows a minimization of the beam spot size by observing the smallest visible interference fringe spacings or the number of visible fringes. It has been demonstrated that X-ray films are also very useful detectors. The main advantage in comparison with the direct exposure CCD chip is the resolution. For the Structurix D3 (Agfa) X-ray film the standard deviation of the resolution was measured to be {sigma}{sub f}=(1.2{+-}0.4) {mu}m, which is about a factor of 6 better than for the direct exposure CCD chip. With the small effective X-ray spot size

  10. Diffraction enhanced X-ray imaging of mammals crystalline lens

    Energy Technology Data Exchange (ETDEWEB)

    Antunes, A. [Departamento de Fisica Aplicada, USP, CP 66318, 05315-970 Sao Paulo, SP (Brazil)]. E-mail: antunes@if.usp.br; Hoennicke, M.G. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Curitiba (Brazil); Safatle, A.M.V. [Faculdade de Medicina Veterinaria e Zootecnia, USP, 05508-900 Sao Paulo, SP (Brazil); Cusatis, C. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Curitiba (Brazil); Moraes Barros, P.S. [Faculdade de Medicina Veterinaria e Zootecnia, USP, 05508-900 Sao Paulo, SP (Brazil); Morelhao, S.L. [Departamento de Fisica Aplicada, USP, CP 66318, 05315-970 Sao Paulo, SP (Brazil)

    2005-08-15

    Crystalline lenses are transparent biological materials where the organization of the lens fibers can also be affected by changes at molecular level, and therefore the structure and morphology of the tissue can be correlated to the loss of transparency of the lens. In this work, internal structure of mammal lenses regarding the long-range ordering of the fibers are investigated by diffraction enhanced X-ray imaging (DEI) radiography. Moreover, DEI and absorption X-ray synchrotron radiographs for healthy and cataractous crystalline lenses are compared. Significant differences in healthy and cataractous crystalline lenses are observed.

  11. X-ray phase sensitive imaging methods: basic physical principles and potential medical applications

    OpenAIRE

    Chen, Guang-Hong; Zambelli, Joseph; Bevins, Nicholas; Qi, Zhihua; Li, Ke

    2010-01-01

    Phase sensitive imaging theoretically allows for a drastic reduction in x-ray dose while simultaneously achieving comparable or better spatial and contrast resolution compared to traditional x-ray absorption based imaging. Several techniques exist to extract the phase information from an x-ray signal, including x-ray interferometry, diffraction enhanced imaging, in-line holography, coded aperture x-ray imaging, and grating-based interferometry. The physics of each method is reviewed, along wi...

  12. X-ray imaging in advanced studies of ophthalmic diseases.

    Science.gov (United States)

    Antunes, Andrea; Safatle, Angélica M V; Barros, Paulo S M; Morelhão, Sérgio L

    2006-07-01

    Microscopic characterization of pathological tissues has one major intrinsic limitation, the small sampling areas with respect to the extension of the tissues. Mapping possible changes on vast tissues and correlating them with large ensembles of clinical cases is not a feasible procedure for studying most diseases, as for instance vision loss related diseases and, in particular, the cataract. Although intraocular lens implants are successful treatments, cataract still is a leading public-health issue that grows in importance as the population increases and life expectancy is extended worldwide. In this work we have exploited the radiation-tissue interaction properties of hard x-rays--very low absorption and scattering--to map distinct lesions on entire eye lenses. At the used synchrotron x-ray photon energy of 20 keV (wavelength lambda=0.062 nm), scattering and refraction are angular resolved effects. It allows the employed x-ray image technique to efficiently characterize two types of lesions in eye lenses under cataractogenesis: distributions of tiny scattering centers and extended areas of fiber cell compaction. The data collection procedure is relatively fast; allowing dozens of samples to be totally imaged (scattering, refraction, and mass absorption images) in a single day of synchrotron beam time. More than 60 cases of canine cataract, not correlated to specific causes, were investigated in this first application of x-rays to image entire lenses. Cortical opacity cases, or partial opacity, could be related to the presence of calcificated tissues at the cortical areas, clearly visible in the images, whose elemental contents were verified by micro x-ray fluorescence as very rich in calcium. Calcificated tissues were also observed at nuclear areas in some cases of hypermature cataract. Total opacity cases without distinguishable amount of scattering centers consist in 70% of the analyzed cases, where remarkable fissure marks owing to extended areas of fiber

  13. Fast X-ray luminescence computed tomography imaging.

    Science.gov (United States)

    Liu, Xin; Liao, Qimei; Wang, Hongkai

    2014-06-01

    X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with X-ray. However, challenges remain in dynamic XLCT imaging, where short scan time, good spatial resolution, and whole-body field of view should be considered simultaneously. In this paper, by the use of a single-view XLCT reconstruction method based on a compressive sensing (CS) technique, incorporating a cone beam XLCT imaging system, we implement fast 3-D XLCT imaging. To evaluate the performance of the method, two types of phantom experiments were performed based on a cone beam XLCT imaging system. In Case 1, one tube filled with the X-ray-excitable nanophosphor (Gd 2O 3 :Eu (3+)) was immerged in different positions in the phantom to evaluate the effect of the source position on single-view XLCT reconstruction accuracy. In Case 2, two tubes filled with Gd 2O 3 :Eu (3+) were immerged in different heights in the phantom to evaluate the whole-body imaging performance of single-view XLCT reconstruction. The experimental results indicated that the tubes used in previous phantom experiments can be resolved from single-view XCLT reconstruction images. The location error is less than 1.2 mm. In addition, since only one view data are needed to implement 3-D XLCT imaging, the acquisition time can be greatly reduced (∼1 frame/s) compared with previous XLCT systems. Hence, the technique is suited for imaging the fast distribution of the X-ray-excitable nanophosphors within a biological object.

  14. Structured illumination for tomographic X-ray diffraction imaging.

    Science.gov (United States)

    Greenberg, Joel A; Hassan, Mehadi; Krishnamurthy, Kalyani; Brady, David

    2014-02-21

    Tomographic imaging of the molecular structure of an object is important for a variety of applications, ranging from medical and industrial radiography to security screening. X-ray diffraction imaging is the preeminent technique for performing molecular analysis of large volumes. Here we propose and demonstrate a new measurement architecture to improve the source and detector efficiency for diffraction imaging. In comparison with previous techniques, our approach reduces the required overall scan time by 1-2 orders of magnitude, which makes possible real-time scanning of a broad range of materials over a large volume using a table-top setup. This method, which relies on structuring spatially the illumination incident on an object moving relative to the X-ray source, is compatible with existing systems and has the potential to significantly enhance performance in an array of areas, such as medical diagnostic imaging and explosives detection.

  15. Proton-induced x-ray fluorescence CT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bazalova-Carter, Magdalena, E-mail: bazalova@stanford.edu; Xing, Lei [Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847 and Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 060-8648 (Japan); Ahmad, Moiz [Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847 (United States); Matsuura, Taeko; Takao, Seishin; Shirato, Hiroki; Umegaki, Kikuo [Department of Medical Physics, Proton Beam Therapy Center, Hokkaido University Hospital, Sapporo 060-8648, Japan and Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 060-8648 (Japan); Matsuo, Yuto [Department of Medical Physics, Proton Beam Therapy Center, Hokkaido University Hospital, Sapporo 060-8648 (Japan); Fahrig, Rebecca [Department of Radiology, Stanford University, Stanford, California 94305 (United States)

    2015-02-15

    Purpose: To demonstrate the feasibility of proton-induced x-ray fluorescence CT (pXFCT) imaging of gold in a small animal sized object by means of experiments and Monte Carlo (MC) simulations. Methods: First, proton-induced gold x-ray fluorescence (pXRF) was measured as a function of gold concentration. Vials of 2.2 cm in diameter filled with 0%–5% Au solutions were irradiated with a 220 MeV proton beam and x-ray fluorescence induced by the interaction of protons, and Au was detected with a 3 × 3 mm{sup 2} CdTe detector placed at 90° with respect to the incident proton beam at a distance of 45 cm from the vials. Second, a 7-cm diameter water phantom containing three 2.2-diameter vials with 3%–5% Au solutions was imaged with a 7-mm FWHM 220 MeV proton beam in a first generation CT scanning geometry. X-rays scattered perpendicular to the incident proton beam were acquired with the CdTe detector placed at 45 cm from the phantom positioned on a translation/rotation stage. Twenty one translational steps spaced by 3 mm at each of 36 projection angles spaced by 10° were acquired, and pXFCT images of the phantom were reconstructed with filtered back projection. A simplified geometry of the experimental data acquisition setup was modeled with the MC TOPAS code, and simulation results were compared to the experimental data. Results: A linear relationship between gold pXRF and gold concentration was observed in both experimental and MC simulation data (R{sup 2} > 0.99). All Au vials were apparent in the experimental and simulated pXFCT images. Specifically, the 3% Au vial was detectable in the experimental [contrast-to-noise ratio (CNR) = 5.8] and simulated (CNR = 11.5) pXFCT image. Due to fluorescence x-ray attenuation in the higher concentration vials, the 4% and 5% Au contrast were underestimated by 10% and 15%, respectively, in both the experimental and simulated pXFCT images. Conclusions: Proton-induced x-ray fluorescence CT imaging of 3%–5% gold solutions in a

  16. AXIOM: Advanced X-ray Imaging of the Magnetosphere

    Science.gov (United States)

    Branduardi-Raymont, G.; Sembay, S. F.; Eastwood, J. P.; Sibeck, D. G.; Abbey, A.; Brown, P.; Carter, J. A.; Carr, C. M.; Forsyth, C.; Kataria, D.; Kemble, S.; Milan, S. E.; Owen, C. J.; Peacocke, L.; Read, A. M.; Coates, A. J.; Collier, M. R.; Cowley, S. W. H.; Fazakerley, A. N.; Fraser, G. W.; Jones, G. H.; Lallement, R.; Lester, M.; Porter, F. S.; Yeoman, T. K.

    2012-01-01

    Planetary plasma and magnetic field environments can be studied in two complementary ways - by in situ measurements, or by remote sensing. While the former provide precise information about plasma behaviour, instabilities and dynamics on local scales, the latter offers the global view necessary to understand the overall interaction of the magnetospheric plasma with the solar wind. Some parts of the Earth's magnetosphere have been remotely sensed, but the majority remains unexplored by this type of measurements. Here we propose a novel and more elegant approach employing remote X-ray imaging techniques. which are now possible thanks to the relatively recent discovery of solar wind charge exchange X-ray emissions in the vicinity of the Earth's magnetosphere. In this article we describe how an appropriately designed and located. X-ray telescope, supported by simultaneous in situ measurements of the solar wind, can be used to image the dayside magnetosphere, magnetosheath and bow shock. with a temporal and spatial resolution sufficient to address several key outstanding questions concerning how the solar wind interacts with the Earth's magnetosphere on a global level. Global images of the dayside magnetospheric boundaries require vantage points well outside the magnetosphere. Our studies have led us to propose 'AXIOM: Advanced X-ray Imaging Of the Magnetosphere', a concept mission using a Vega launcher with a LISA Pathfinder-type Propulsion Module to place the spacecraft in a Lissajous orbit around the Earth - Moon Ll point. The model payload consists of an X-ray Wide Field Imager, capable of both imaging and spectroscopy, and an in situ plasma and magnetic field measurement package. This package comprises a Proton-Alpha Sensor, designed to measure the bulk properties of the solar wind, an Ion Composition Analyser, to characterize the minor ion populations in the solar wind that cause charge exchange emission, and a Magnetometer, designed to measure the strength and

  17. High Resolution Energetic X-ray Imager (HREXI)

    Science.gov (United States)

    Grindlay, Jonathan

    We propose to design and build the first imaging hard X-ray detector system that incorporates 3D stacking of closely packed detector readouts in finely-spaced imaging arrays with their required data processing and control electronics. In virtually all imaging astronomical detectors, detector readout is done with flex connectors or connections that are not vertical but rather horizontal , requiring loss of focal plane area. For high resolution pixel detectors needed for high speed event-based X-ray imaging, from low energy applications (CMOS) with focusing X-ray telescopes, to hard X-ray applications with pixelated CZT for large area coded aperture telescopes, this new detector development offers great promise. We propose to extend our previous and current APRA supported ProtoEXIST program that has developed the first large area imaging CZT detectors and demonstrated their astrophysical capabilities on two successful balloon flight to a next generation High Resolution Energetic X-ray Imager (HREXI), which would incorporate microvia technology for the first time to connect the readout ASIC on each CZT crystal directly to its control and data processing system. This 3-dimensional stacking of detector and readout/control system means that large area (>2m2) imaging detector planes for a High Resolution Wide-field hard X-ray telescope can be built with initially greatly reduced detector gaps and ultimately with no gaps. This increases detector area, efficiency, and simplicity of detector integration. Thus higher sensitivity wide-field imagers will be possible at lower cost. HREXI will enable a post-Swift NASA mission such as the EREXS concept proposed to PCOS to be conducted as a future MIDEX mission. This mission would conduct a high resolution (<2 arcmin) , broad band (5 200 keV) hard X-ray survey of black holes on all scales with ~10X higher sensitivity than Swift. In the current era of Time Domain Astrophysics, such a survey capability, in conjunction with a n

  18. A compact PC-based X-ray imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Asimidis, A. [Physics Department, Laboratory B, University of Ioannina, GR-45110 Ioannina (Greece)]. E-mail: aasimid@cc.uoi.gr; Evangelou, I. [Physics Department, Laboratory B, University of Ioannina, GR-45110 Ioannina (Greece); Kokkas, P. [Physics Department, Laboratory B, University of Ioannina, GR-45110 Ioannina (Greece); Manthos, N. [Physics Department, Laboratory B, University of Ioannina, GR-45110 Ioannina (Greece); Triantis, F. [Physics Department, Laboratory B, University of Ioannina, GR-45110 Ioannina (Greece); Speller, R.D. [Medical Physics and Bioengineering Department, University College London, 11-20 Capper Street, London WC1E 6JA (United Kingdom); Hall, G. [Physics Department, Imperial College, London SW7 2BW (United Kingdom); Stelt, P.F. van der [Department of Oral and Maxillofacial Radiology, Academic Centre for Dentistry Amsterdam, NL 1066 EA Amsterdam (Netherlands)

    2007-04-01

    A compact, portable PC-based X-ray imaging system has been developed based on a 2D silicon microstrip sensor and particle physics readout electronics. The sensor is housed in a specially built hybrid, which also hosts the front-end electronics. The control and the readout electronics used are based on the standard PCI and PMC architectures and were originally developed for High Energy Physics Experiments. The use of PCI based electronics and the development of the control software for the PC-Linux platform led to a compact, portable, low cost imaging system. The system was initially tested and evaluated with beta particles from a {sup 90}Sr radioactive source, gamma rays from an {sup 241}Am radioactive source and cosmic rays, and it displayed consistent response. It was then operated using a compact X-ray machine with Mo tube and images of various targets were reconstructed offline using the ROOT data analysis package.

  19. High spatial resolution hard X-ray microscope using X-ray refractive lens and phase contrast imaging experiments

    CERN Document Server

    Kohmura, Y; Takeuchi, A; Takano, H; Suzuki, Y; Ishikawa, T; Ohigashi, T; Yokosuka, H

    2001-01-01

    A high spatial resolution X-ray microscope was constructed using an X-ray refractive lens as an objective. The spatial resolution was tested using 18 keV X-ray. A 0.4 mu m line and 0.4 mu m space tantalum test pattern was successfully resolved. Using the similar setup with the addition of a phase plate, a Zernike type phase-contrast microscopy experiment was carried out for the phase retrieval of the samples. Two-dimensional phase-contrast images were successfully taken for the first time in the hard X-ray region. Images of a gold mesh sample were analyzed and the validity of this method was indicated. An improvement of the lens, however, is required for the precise phase retrieval of the samples.

  20. The Soft X-ray Imager on board EXIST

    CERN Document Server

    Natalucci, L; Panessa, F; Ubertini, P; Tagliaferri, G; Della Ceca, R; Ghisellini, G; Pareschi, G; Villa, G; Caraveo, P; Fiorini, M; Uslenghi, M; Grindlay, J E; Ramsey, B

    2010-01-01

    The Soft X-ray Imager (SXI) is one of the three instruments on board EXIST, a multi-wavelength observatory in charge of performing a global survey of the sky in hard X-rays searching for Super-massive Black Holes (Grindlay & Natalucci, these Proceedings). One of the primary objectives of EXIST is also to study with unprecedented sensitivity the most unknown high energy sources in the Universe, like high redshift GRBs, which will be pointed promptly by the Spacecraft by autonomous trigger based on hard X-ray localization on board. The presence of a soft X-ray telescope with an effective area of about 950cm2 in the energy band 0.2-3 keV and extended response up to 10 keV will allow to make broadband studies from 0.1 to 600 keV. In particular, investigations of the spectra components and states of AGNs and monitoring of variability of sources, study of the prompt and afterglow emission of GRBs since the early phases, which will help to constrain the emission models and finally, help the identification of sou...

  1. Magnetospheric Atmospheric X-ray Imaging Experiment (MAXIE)

    Science.gov (United States)

    Imhof, W. L.; Voss, H. D.; Mobilia, J.; Datlowe, D. W.; Chinn, V. L.; Hilsenrath, M.; Vondrak, R. R.

    1996-01-01

    This report summarizes the activities sponsored by the Office of Naval Research for the Magnetospheric Atmospheric X-ray Imaging Experiment (MAXIE). The MAXIE instrument was developed as a joint activity of Lockheed, The Aerospace Corporation, and the University of Bergen, Norway. Lockheed was responsible for the overall management of the program, interfacing with the appropriate government agencies, the overall electrical and mechanical design, flight software, environmental testing, spacecraft integration activities, on orbit checkout, and data processing activities. The Magnetospheric Atmospheric X-ray Imaging Experiment (MAXIE), the ONR 401 experiment, is the first in a new class of satellite-borne remote sensing instruments. The primary innovation is the ability to obtain rapid, sequential, images with high sensitivity of the earth's X ray aurora from a low altitude polar orbiting satellite. These images can be used to identify dynamic temporal variations in the three-dimensional (energy and position) distribution of electron precipitation into the atmosphere. MAXIE was launched on the TIROS NOAA-13 satellite on 9 August 1993. The experiment performed well during its turn-on sequence; however, the spacecraft bus failed on 21 August 1993. New spacebased technologies successfully used in MAXIE were mixed-mode ASIC microcircuits, a zero torque scanning system with associated viscoelastic damping, a paraffin stow release mechanism, a parallel integrating PHA processor, a low noise Si(Li) sensor telescope, and an advanced thermal cooling system. MAXIE's on orbit operation, control of penetrating particle backgrounds, and scientific data indicated good overall performance.

  2. Water Window Ptychographic Imaging with Characterized Coherent X-rays

    CERN Document Server

    Rose, Max; Dzhigaev, Dmitry; Gorobtsov, Oleg; Senkbeil, Tobias; von Gundlach, Andreas; Gorniak, Thomas; Shabalin, Anatoly; Viefhaus, Jens; Rosenhahn, Axel; Vartanyants, Ivan

    2015-01-01

    We report on a ptychographical coherent diffractive imaging experiment in the water window with focused soft X-rays at $500~\\mathrm{eV}$. An X-ray beam with high degree of coherence was selected for ptychography at the P04 beamline of the PETRA III synchrotron radiation source. We measured the beam coherence with the newly developed non-redundant array method. A pinhole $2.6~\\mathrm{\\mu m}$ in size selected the coherent part of the beam and was used for ptychographic measurements of a lithographically manufactured test sample and fossil diatom. The achieved resolution was $53~\\mathrm{nm}$ for the test sample and only limited by the size of the detector. The diatom was imaged at a resolution better than $90~\\mathrm{nm}$.

  3. Study of X-ray Imaging of GEM Detector

    Institute of Scientific and Technical Information of China (English)

    LI; Xiao-mei; HU; Shou-yang; JIAN; Si-yu; ZHOU; Jing; LI; Xing-long; LIANG; Hao; ZHOU; Shu-hua

    2015-01-01

    A 10cm×10cm GEM detector made by 3GEM foils was used in the X-ray imaging experiment.2-D strips readout mode was used and each dimension has 256channels with a pitch of 400micrometer.APV25front-end readout chip was introduced in the detector,and the backplane connectors were improved in order to adapt the electronics with GEM detector.Since each

  4. High-energy x-ray imaging spectrometer (HEXIS)

    Science.gov (United States)

    Matteson, James L.; Gruber, Duane E.; Heindl, William A.; Pelling, Michael R.; Peterson, Laurence E.; Rothschild, Richard E.; Skelton, Robert E.; Hink, Paul L.; Slavis, Kimberly R.; Binns, W. Robert

    1998-11-01

    HEXIS is a MIDEX-class mission concept for x-ray astronomy. Its objectives are to improve our knowledge of the high energy x-ray sky by increasing the number of sources above 20 keV to > 2,000, discovering transient sources such as x-ray novae and gamma-ray bursts, and making spectral and temporal studies of the sources. With mission life > 3 years, a 1-year all-sky survey sensitivity of approximately 0.3 mCrab, and continuous monitoring of the entire visible sky, HEXIS will provide unprecedented capabilities. Source positions will be determined to accuracies of a few arcmin or better. Spectra will be determined with an energy resolution of a few keV and source variability will be studied on time scales from CZT detectors operating from approximately 5 keV to 200 keV. Detector planes are built with 41 cm(superscript 2) CZT detector modules which employ crossed-strip readout to obtain a pixel size of 0.5 mm. Nine modules are grouped in a 369 cm(superscript 2) array for each imager. In the past 2 years significant progress has been made on techniques requires for HEXIS: position-sensitive CZT detectors and ASIC readout, coded mask imaging, and background properties at balloon altitudes. Scientific and technical details of HEXIS are presented together with result form tests of detectors and a coded mask imager.

  5. Detectors for the future of X-ray imaging.

    Science.gov (United States)

    Aslund, M; Fredenberg, E; Telman, M; Danielsson, M

    2010-01-01

    In recent decades, developments in detectors for X-ray imaging have improved dose efficiency. This has been accomplished with for example, structured scintillators such as columnar CsI, or with direct detectors where the X rays are converted to electric charge carriers in a semiconductor. Scattered radiation remains a major noise source, and fairly inefficient anti-scatter grids are still a gold standard. Hence, any future development should include improved scatter rejection. In recent years, photon-counting detectors have generated significant interest by several companies as well as academic research groups. This method eliminates electronic noise, which is an advantage in low-dose applications. Moreover, energy-sensitive photon-counting detectors allow for further improvements by optimising the signal-to-quantum-noise ratio, anatomical background subtraction or quantitative analysis of object constituents. This paper reviews state-of-the-art photon-counting detectors, scatter control and their application in diagnostic X-ray medical imaging. In particular, spectral imaging with photon-counting detectors, pitfalls such as charge sharing and high rates and various proposals for mitigation are discussed.

  6. XIPE: the X-ray Imaging Polarimetry Explorer

    CERN Document Server

    Soffitta, Paolo; Bellazzini, Ronaldo; Braga, João; Costa, Enrico; Fraser, George W; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; Poutanen, Juri; Reglero, Victor; Santangelo, Andrea; Sunyaev, Rashid A; Tagliaferri, Gianpiero; Weisskopf, Martin; Aloisio, Roberto; Amato, Elena; Attiná, Primo; Axelsson, Magnus; Baldini, Luca; Basso, Stefano; Bianchi, Stefano; Blasi, Pasquale; Bregeon, Johan; Brez, Alessandro; Bucciantini, Niccoló; Burderi, Luciano; Burwitz, Vadim; Casella, Piergiorgio; Churazov, Eugene; Civitani, Marta; Covino, Stefano; da Silva, Rui Miguel Curado; Cusumano, Giancarlo; Dadina, Mauro; D'Amico, Flavio; De Rosa, Alessandra; Di Cosimo, Sergio; Di Persio, Giuseppe; Di Salvo, Tiziana; Dovciak, Michal; Elsner, Ronald; Eyles, Chris J; Fabian, Andrew C; Fabiani, Sergio; Feng, Hua; Giarrusso, Salvatore; Goosmann, René W; Grandi, Paola; Grosso, Nicolas; Israel, Gianluca; Jackson, Miranda; Kaaret, Philip; Karas, Vladimir; Kuss, Michael; Lai, Dong; La Rosa, Giovanni; Larsson, Josefin; Larsson, Stefan; Latronico, Luca; Maggio, Antonio; Maia, Jorge; Marin, Frédéric; Massai, Marco Maria; Mineo, Teresa; Minuti, Massimo; Moretti, Elena; Muleri, Fabio; O'Dell, Stephen L; Pareschi, Giovanni; Peres, Giovanni; Pesce, Melissa; Petrucci, Pierre-Olivier; Pinchera, Michele; Porquet, Delphine; Ramsey, Brian; Rea, Nanda; Reale, Fabio; Rodrigo, Juana Maria; Różańska, Agata; Rubini, Alda; Rudawy, Pawel; Ryde, Felix; Salvati, Marco; Júnior, Valdivino Alexandre de Santiago; Sazonov, Sergey; Sgró, Carmelo; Silver, Eric; Spandre, Gloria; Spiga, Daniele; Stella, Luigi; Tamagawa, Toru; Tamborra, Francesco; Tavecchio, Fabrizio; Dias, Teresa Teixeira; van Adelsberg, Matthew; Wu, Kinwah; Zane, Silvia

    2013-01-01

    X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017 but not selected. XIPE ...

  7. IXPE - The Imaging X-Ray Polarimetry Explorer

    Science.gov (United States)

    Ramsey, Brian

    2014-01-01

    The Imaging X-ray Polarimetry Explorer (IXPE) is a Small Explorer Mission that will be proposed in response to NASA's upcoming Announcement of Opportunity. IXPE will transform our understanding of the most energetic and exotic astrophysical objects, especially neutron stars and black holes, by measuring the linear polarization of astronomical objects as a function of energy, time and, where relevant, position. As the first dedicated polarimetry observatory IXPE will add a new dimension to the study of cosmic sources, enlarging the observational phase space and providing answers to fundamental questions. IXPE will feature x-ray optics fabricated at NASA/MSFC and gas pixel focal plane detectors provided by team members in Italy (INAF and INFN). This presentation will give an overview of the proposed IXPE mission, detailing the payload configuration, the expected sensitivity, and a typical observing program.

  8. Contrast imaging with a monochromatic x-ray scanner

    Science.gov (United States)

    Pole, Donald J.; Popovic, Kosta; Williams, Mark B.

    2008-03-01

    We are currently developing a monochromatic x-ray source for small animal tomographic imaging. This source consists of a conventional cone beam microfocus x-ray tube with a tungsten target coupled to a filter that uses Bragg diffraction to transmit only x-rays within a narrow energy range (~3 keV FWHM). A tissue-equivalent mouse phantom was used to a) evaluate how clearly CT imaging using the quasi-monoenergetic beam is able to differentiate tissue types compared to conventional polyenergetic CT, and b) to test the ability of the source and Bragg filter combination to perform dual energy, iodine contrast enhanced imaging. Single slice CT scans of the phantom were obtained both with polyenergetic (1.8 mm Al filtration) and quasi-monoenergetic beams. Region of interest analysis showed that pixel value variance was signifcantly reduced in the quasi-monochromatic case compared to the polyenergetic case, suggesting a reduction in the variance of the linear attenuation coefficients of the tissue equivalent materials due to the narrower energy spectrum. To test dual energy iodine K-edge imaging, vials containing solutions with a range of iodine contrasts were added to the phantom. Single-slice CT scans were obtained using spectra with maximum values at 30 and 35 keV, respectively. Analysis of the resulting difference images (35 keV image - 30 keV image) shows that the magnitude of the difference signal produced by iodine exceeds that of bone for iodine concentrations above ~20 mg/ml, and that of muscle and fat tissues for iodine concentrations above ~5 mg/ml.

  9. Detection of soft X-rays from Alpha Lyrae and Eta Bootis with an imaging X-ray telescope

    Science.gov (United States)

    Topka, K.; Fabricant, D.; Harnden, F. R., Jr.; Gorenstein, P.; Rosner, R.

    1979-01-01

    Results are presented for observations of Alpha Lyr (Vega) and Eta Boo with an imaging X-ray telescope during two rocket flights. It is found that Vega and Eta Boo are soft X-ray sources with respective luminosities of approximately 3 x 10 to the 28th erg/s (0.15-0.8 keV) and 1 x 10 to the 29th erg/s (0.15-1.5 keV). Surface X-ray luminosities of about 640,000 erg/sq cm per sec for Vega and 300,000 erg/sq cm per sec for Eta Boo are estimated and shown to fall within the range of solar coronal X-ray emission. It is concluded that in view of the substantially larger surface areas of these stars, the relatively large total soft X-ray luminosity (as compared with that of the sun) can in both cases be understood as resulting from a moderately active corona, although the Vega observation is in severe conflict with simple models for X-ray emission from single main-sequence stars.

  10. A new method for determining the sensitivity of X-ray imaging observations and the X-ray number counts

    CERN Document Server

    Georgakakis, A; Laird, E S; Aird, J; Trichas, M

    2008-01-01

    We present a new method for determining the sensitivity of X-ray imaging observations, which correctly accounts for the observational biases that affect the probability of detecting a source of a given X-ray flux, without the need to perform a large number of time consuming simulations. We use this new technique to estimate the X-ray source counts in different spectral bands (0.5-2, 0.5-10, 2-10 and 5-10keV) by combining deep pencil-beam and shallow wide-area Chandra observations. The sample has a total of 6295 unique sources over an area of $\\rm 11.8deg^2$ and is the largest used to date to determine the X-ray number counts. We determine, for the first time, the break flux in the 5-10 keV band, in the case of a double power-law source count distribution. We also find an upturn in the 0.5-2keV counts at fluxes below about 6e-17erg/s/cm2. We show that this can be explained by the emergence of normal star-forming galaxies which dominate the X-ray population at faint fluxes. The fraction of the diffuse X-ray bac...

  11. X-ray image enhancement via determinant based feature selection.

    Science.gov (United States)

    Tappenden, R; Hegarty, J; Broughton, R; Butler, A; Coope, I; Renaud, P

    2013-12-01

    Previous work has investigated the feasibility of using Eigenimage-based enhancement tools to highlight abnormalities on chest X-rays (Butler et al in J Med Imaging Radiat Oncol 52:244-253, 2008). While promising, this approach has been limited by computational restrictions of standard clinical workstations, and uncertainty regarding what constitutes an adequate sample size. This paper suggests an alternative mathematical model to the above referenced singular value decomposition method, which can significantly reduce both the required sample size and the time needed to perform analysis. Using this approach images can be efficiently separated into normal and abnormal parts, with the potential for rapid highlighting of pathology.

  12. Chandra X-Ray Observatory Image of Crab Nebula

    Science.gov (United States)

    1999-01-01

    After barely 2 months in space, the Chandra X-Ray Observatory (CXO) took this sturning image of the Crab Nebula, the spectacular remains of a stellar explosion, revealing something never seen before, a brilliant ring around the nebula's heart. The image shows the central pulsar surrounded by tilted rings of high-energy particles that appear to have been flung outward over a distance of more than a light-year from the pulsar. Perpendicular to the rings, jet-like structures produced by high-energy particles blast away from the pulsar. Hubble Space Telescope images have shown moving knots and wisps around the neutron star, and previous x-ray images have shown the outer parts of the jet and hinted at the ring structure. With CXO's exceptional resolution, the jet can be traced all the way in to the neutron star, and the ring pattern clearly appears. The image was made with CXO's Advanced Charge-Coupled Device (CCD) Imaging Spectrometer (ACIS) and High Energy Transmission Grating. The Crab Nebula, easily the most intensively studied object beyond our solar system, has been observed using virtually every astronomical instrument that could see that part of the sky

  13. 21 CFR 892.1630 - Electrostatic x-ray imaging system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Electrostatic x-ray imaging system. 892.1630... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1630 Electrostatic x-ray imaging system. (a) Identification. An electrostatic x-ray imaging system is a device intended for...

  14. The Al sub x Ga sub 1 sub - sub x As X-ray imaging detector

    CERN Document Server

    Pozela, K; Dileenas, A; Jasutis, V; Dapkus, L; Jucienee, V

    2001-01-01

    An X-ray imaging detector based on the graded-gap Al sub x Ga sub 1 sub - sub x As structures with the CCD camera as an image read-out tool is investigated. High X-ray - light conversion efficiency and X-ray image spatial resolution better than 20 line/mm are obtained.

  15. Moving-Article X-Ray Imaging System and Method for 3-D Image Generation

    Science.gov (United States)

    Fernandez, Kenneth R. (Inventor)

    2012-01-01

    An x-ray imaging system and method for a moving article are provided for an article moved along a linear direction of travel while the article is exposed to non-overlapping x-ray beams. A plurality of parallel linear sensor arrays are disposed in the x-ray beams after they pass through the article. More specifically, a first half of the plurality are disposed in a first of the x-ray beams while a second half of the plurality are disposed in a second of the x-ray beams. Each of the parallel linear sensor arrays is oriented perpendicular to the linear direction of travel. Each of the parallel linear sensor arrays in the first half is matched to a corresponding one of the parallel linear sensor arrays in the second half in terms of an angular position in the first of the x-ray beams and the second of the x-ray beams, respectively.

  16. Dark-field hyperspectral X-ray imaging.

    Science.gov (United States)

    Egan, Christopher K; Jacques, Simon D M; Connolley, Thomas; Wilson, Matthew D; Veale, Matthew C; Seller, Paul; Cernik, Robert J

    2014-05-01

    In recent times, there has been a drive to develop non-destructive X-ray imaging techniques that provide chemical or physical insight. To date, these methods have generally been limited; either requiring raster scanning of pencil beams, using narrow bandwidth radiation and/or limited to small samples. We have developed a novel full-field radiographic imaging technique that enables the entire physio-chemical state of an object to be imaged in a single snapshot. The method is sensitive to emitted and scattered radiation, using a spectral imaging detector and polychromatic hard X-radiation, making it particularly useful for studying large dense samples for materials science and engineering applications. The method and its extension to three-dimensional imaging is validated with a series of test objects and demonstrated to directly image the crystallographic preferred orientation and formed precipitates across an aluminium alloy friction stir weld section.

  17. Hybrid Pixel Detectors for gamma/X-ray imaging

    Science.gov (United States)

    Hatzistratis, D.; Theodoratos, G.; Zografos, V.; Kazas, I.; Loukas, D.; Lambropoulos, C. P.

    2015-09-01

    Hybrid pixel detectors are made by direct converting high-Z semi-insulating single crystalline material coupled to complementary-metal-oxide semiconductor (CMOS) readout electronics. They are attractive because direct conversion exterminates all the problems of spatial localization related to light diffusion, energy resolution, is far superior from the combination of scintillation crystals and photomultipliers and lithography can be used to pattern electrodes with very fine pitch. We are developing 2-D pixel CMOS ASICs, connect them to pixilated CdTe crystals with the flip chip and bump bonding method and characterize the hybrids. We have designed a series of circuits, whose latest member consists of a 50×25 pixel array with 400um pitch and an embedded controller. In every pixel a full spectroscopic channel with time tagging information has been implemented. The detectors are targeting Compton scatter imaging and they can be used for coded aperture imaging too. Hybridization using CMOS can overcome the limit put on pixel circuit complexity by the use of thin film transistors (TFT) in large flat panels. Hybrid active pixel sensors are used in dental imaging and other applications (e.g. industrial CT etc.). Thus X-ray imaging can benefit from the work done on dynamic range enhancement methods developed initially for visible and infrared CMOS pixel sensors. A 2-D CMOS ASIC with 100um pixel pitch to demonstrate the feasibility of such methods in the context of X-ray imaging has been designed.

  18. The imaging of nanostructures with novel x-ray methods

    Science.gov (United States)

    Dietze, Sebastian

    The use of x-rays to probe matter is an ever increasing popular technique due to their short wavelength that can achieve better than atomic resolution; chemical selectivity that permit the separation of material contributions; and tunable interaction strength allowing a wide class of materials to be probed including interfaced and bulk structures. As more powerful sources of x-rays have become available in the form of synchrotrons and linear accelerators, new and inventive experimental method have emerged to access the unknown. In this dissertation, three novel uses of x-rays are advanced to study a wide class materials. Since the next generation of x-ray sources will feature highly brilliant x-ray beams, they will enable the imaging of local nanoscale structures with unprecedented resolution. A general formalism to predict the achievable spatial resolution in coherent diffractive imaging (CDI), based solely on diffracted intensities, is provided. The coherent dose necessary to reach atomic resolution depends significantly on the atomic scale structure, where amorphous materials or disordered materials require less dose than crystalline materials. A reduction in dose can be larger than three-orders of magnitude as compared to the expected scaling for uniform density materials. Additionally, dose reduction for crystalline materials are predicted at certain resolutions based only on their unit cell dimensions and structure factors. An extension of dichroic coherent diffractive imaging of thin films with perpendicular magnetic anisotropy is made from a uniform case to one that contains charge contributions. With the use of linear polarized x-rays near resonant edges, the charge and magnetic scattering can be reconstructed. First, an approximate manual separation is made before reconstruction to obtain the magnetic domains of a Au patterned GdFe multilayer thin film. This is then compared to a direct reconstruction using the two coherent modes contributed by the right

  19. Long bone X-ray image stitching using Camera Augmented Mobile C-arm.

    Science.gov (United States)

    Wang, Lejing; Traub, Joerg; Heining, Sandro Michael; Benhimane, Selim; Euler, Ekkehard; Graumann, Rainer; Navab, Nassir

    2008-01-01

    X-ray images are widely used during surgery for long bone fracture fixation. Mobile C-arms provide X-ray images which are used to determine the quality of trauma reduction, i.e. the extremity length and mechanical axis of long bones. Standard X-ray images have a narrow field of view and can not visualize the entire long bone on a single image. In this paper, we propose a novel method to generate panoramic X-ray images in real time by using the previously introduced Camera Augmented Mobile C-arm. This advanced mobile C-arm system acquires registered X-ray and optical images by construction, which facilitates the generation of panoramic X-ray images based on first stitching the optical images and then embedding the X-ray images. We additionally introduce a method to reduce the parallax effect that leads to the blurring and measurement error on panoramic X-ray images. Visual marker tracking is employed to automatically stitch the sequence of video images and to rectify images. Our proposed method is suitable for intra-operative usage generating panoramic X-ray images, which enable metric measurements, with less radiation and without requirement of fronto-parallel setup and overlapping X-ray images. The results show that the panoramic X-ray images generated by our method are accurate enough (errors less than 1%) for metric measurements and suitable for many clinical applications in trauma reduction.

  20. Structure determination of spider silk from X-ray images

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Stephan; Zippelius, Annette [Universitaet Goettingen, Institut fuer Theoretische Physik (Germany); Meling, Martin [Max-Planck-Institut fuer biophysikalische Chemie, Goettingen (Germany); Glisovic, Anja; Salditt, Tim [Universitaet Goettingen, Institut fuer Roentgenphysik (Germany)

    2008-07-01

    Spider silk consists of interconnected crystallites, which are typically aligned along the fiber axis. We present a method to systematically determine the structure of these crystallites. Hereby we introduce a model that calculates the scattering function G(q) which is fitted to the measured X-ray image (silk from nephila clavipes). With it, the crystallites' size, the constitution and dimensions of their unit cell, as well as their tilt with respect to the fiber axis is identified, and furthermore the effect of coherent scattering from different crystallites is investigated. The shown methods and the presented model can easily be generalized to a wide class of composite materials.

  1. Global X-ray Imaging of the Earth's Magnetosphere

    Science.gov (United States)

    Branduardi-Raymont, G.

    2012-04-01

    Plasma and magnetic field environments can be studied in situ, or by remote sensing. In situ measurements return precise information about plasma composition, instabilities and dynamics, but cannot provide the global view necessary to understand the overall behaviour and evolution of the plasma, which instead can be explored by remote imaging. We propose a new approach by remote global X-ray imaging, now possible thanks to the relatively recent discovery of solar wind charge-exchange X-ray emission; this has been found, by observatories such as XMM-Newton, to occur in the vicinity of the Earth's magnetosphere and to peak in the sub-solar magnetosheath, where both solar wind and neutral exospheric densities are high. We describe how an appropriately designed and located X-ray telescope, supported by simultaneous in situ measurements of the solar wind, can be used to image the Earth's dayside magnetosphere, magnetosheath and bow shock, with temporal and spatial resolutions sufficient to address key outstanding questions concerning how the solar wind interacts with planetary magnetospheres. This medium-size mission incorporates a wide-field soft X-ray telescope, using micropore optics and CCD detectors, for imaging and spectroscopy, a proton and alpha particle sensor designed to measure the bulk properties of the solar wind, an ion composition analyser which aims to characterise the populations of minor ions in the solar wind, and a magnetometer for accurate measurements of the strength and direction of the magnetic field. Details of the mission profile will be presented, as well as simulations of the expected performance for possible mission configurations. The AXIOM Team: G. Branduardi-Raymont(1), S. F. Sembay(2), J. P. Eastwood(3), D. G. Sibeck(4), A. Abbey(2), P. Brown(3), J. A. Carter(2), C. M. Carr(3), C. Forsyth(1), D. Kataria(1), S. Milan(2), C. J. Owen(1), A. M. Read(2), C. S. Arridge(1), A. J. Coates(1), M. R. Collier(4), S. W. H. Cowley(2), G. Fraser(2), G

  2. Imaging properties and its improvements of scanning/imaging x-ray microscope

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Akihisa, E-mail: take@spring8.or.jp; Uesugi, Kentaro; Suzuki, Yoshio [Japan Synchrotron Radiation Research Institute (JASRI / SPring-8), Sayo, Hyogo 679-5198 (Japan)

    2016-01-28

    A scanning / imaging X-ray microscope (SIXM) system has been developed at SPring-8. The SIXM consists of a scanning X-ray microscope with a one-dimensional (1D) X-ray focusing device and an imaging (full-field) X-ray microscope with a 1D X-ray objective. The motivation of the SIXM system is to realize a quantitative and highly-sensitive multimodal 3D X-ray tomography by taking advantages of both the scanning X-ray microscope using multi-pixel detector and the imaging X-ray microscope. Data acquisition process of a 2D image is completely different between in the horizontal direction and in the vertical direction; a 1D signal is obtained with the linear-scanning while the other dimensional signal is obtained with the imaging optics. Such condition have caused a serious problem on the imaging properties that the imaging quality in the vertical direction has been much worse than that in the horizontal direction. In this paper, two approaches to solve this problem will be presented. One is introducing a Fourier transform method for phase retrieval from one phase derivative image, and the other to develop and employ a 1D diffuser to produce an asymmetrical coherent illumination.

  3. Skull x-ray

    Science.gov (United States)

    X-ray - head; X-ray - skull; Skull radiography; Head x-ray ... There is low radiation exposure. X-rays are monitored and regulated to provide the minimum amount of radiation exposure needed to produce the image. Most ...

  4. Neck x-ray

    Science.gov (United States)

    X-ray - neck; Cervical spine x-ray; Lateral neck x-ray ... There is low radiation exposure. X-rays are monitored so that the lowest amount of radiation is used to produce the image. Pregnant women and ...

  5. Imaging bacterial spores by soft-x-ray microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Stead, A.D.; Ford, T.W. [Univ. of London, Surrey (United Kingdom); Judge, J. [Unilever plc, Sharnbrook (United Kingdom)] [and others

    1997-04-01

    Bacterial spores are able to survive dehydration, but neither the physiological nor structural basis of this have been fully elucidated. Furthermore, once hydrated, spores often require activation before they will germinate. Several treatments can be used to activate spores, but in the case of Bacillus subtlis the most effective is heat treatment. The physiological mechanism associated with activation is also not understood, but some workers suggest that the loss of calcium from the spores may be critical. However, just prior to germination, the spores change from being phase bright to phase dark when viewed by light microscopy. Imaging spores by soft x-ray microscopy is possible without fixation. Thus, in contrast to electron microscopy, it is possible to compare the structure of dehydrated and hydrated spores in a manner not possible previously. A further advantage is that it is possible to monitor individual spores by phase contrast light microscopy immediately prior to imaging with soft x-rays; whereas, with both electron microscopy and biochemical studies, it is a population of spores being studied without knowledge of the phase characteristics of individual spores. This study has therefore tried to compare dehydrated and hydrated spores and to determine if there is a mass loss from individual spores as they pass the transition from being phase bright to phase dark.

  6. Materials characterization using micro-x-ray fluorescence elemental imaging.

    Energy Technology Data Exchange (ETDEWEB)

    Havrilla, G. J. (George J.); Miller, T. C. (Thomasin C.); Joseph, M. R. (Martha R.)

    2002-01-01

    Materials characterization continues to be a key challenge in a variety of programs. Although bulk elemental composition provides overall concentration of both major and trace elements, the distribution of these elements both on micro and macro scales can determine the performance and ultimately the physical properties of the materials. Hence elemental imaging can provide a new level of information for major and in some cases bulk trace concentrations of elements. Micro X-ray fluorescence (MXRF) offers unique capabilities in terms of elemental imaging. This approach is based on a meso scale level of resolution around 50 micrometer X-ray spot size. When coupled with a moveable stage, specimens several inches on a side can be imaged with surprising detail. In most instances, qualitative images are sufficient to illustrate the elemental heterogeneity. This information can then be used to determine if the material meets the desired physical characteristics and whether this is due to the observed heterogeneity or in spite of it. Several examples of elemental imaging will be presented. These will include the aging of polymers and the effects of residual organotin catalyst. The tin can be imaged using MXRF and has been show to be mobile within the polymeric material over time. Corrosion is a serious issue throughout the industrial world. A specific example of chloride attack on a metal, which creates problems in waste storage. Finally, MXRF used in high throughput screening in the development of novel peptide receptors will be shown. The advantage of MXRF is that no fluorescent tags need be added to the target molecules. This insures the unhindered interaction of the target molecules and allows for additional characterization using molecular spectroscopic techniques.

  7. High energy X-ray phase and dark-field imaging using a random absorption mask

    Science.gov (United States)

    Wang, Hongchang; Kashyap, Yogesh; Cai, Biao; Sawhney, Kawal

    2016-07-01

    High energy X-ray imaging has unique advantage over conventional X-ray imaging, since it enables higher penetration into materials with significantly reduced radiation damage. However, the absorption contrast in high energy region is considerably low due to the reduced X-ray absorption cross section for most materials. Even though the X-ray phase and dark-field imaging techniques can provide substantially increased contrast and complementary information, fabricating dedicated optics for high energies still remain a challenge. To address this issue, we present an alternative X-ray imaging approach to produce transmission, phase and scattering signals at high X-ray energies by using a random absorption mask. Importantly, in addition to the synchrotron radiation source, this approach has been demonstrated for practical imaging application with a laboratory-based microfocus X-ray source. This new imaging method could be potentially useful for studying thick samples or heavy materials for advanced research in materials science.

  8. Imaging Nonequilibrium Atomic Vibrations with X-ray Diffuse Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Trigo, M.; Chen, J.; Vishwanath, V.H.; /SLAC; Sheu, Y.M.; /Michigan U.; Graber, T.; Henning, R.; /U. Chicago; Reis, D; /SLAC /Stanford U., Appl. Phys. Dept.

    2011-03-03

    We use picosecond x-ray diffuse scattering to image the nonequilibrium vibrations of the lattice following ultrafast laser excitation. We present images of nonequilibrium phonons in InP and InSb throughout the Brillouin-zone which remain out of equilibrium up to nanoseconds. The results are analyzed using a Born model that helps identify the phonon branches contributing to the observed features in the time-resolved diffuse scattering. In InP this analysis shows a delayed increase in the transverse acoustic (TA) phonon population along high-symmetry directions accompanied by a decrease in the longitudinal acoustic (LA) phonons. In InSb the increase in TA phonon population is less directional.

  9. High resolution, multiple-energy linear sweep detector for x-ray imaging

    Science.gov (United States)

    Perez-Mendez, V.; Goodman, C.A.

    1996-08-20

    Apparatus is disclosed for generating plural electrical signals in a single scan in response to incident X-rays received from an object. Each electrical signal represents an image of the object at a different range of energies of the incident X-rays. The apparatus comprises a first X-ray detector, a second X-ray detector stacked upstream of the first X-ray detector, and an X-ray absorber stacked upstream of the first X-ray detector. The X-ray absorber provides an energy-dependent absorption of the incident X-rays before they are incident at the first X-ray detector, but provides no absorption of the incident X-rays before they are incident at the second X-ray detector. The first X-ray detector includes a linear array of first pixels, each of which produces an electrical output in response to the incident X-rays in a first range of energies. The first X-ray detector also includes a circuit that generates a first electrical signal in response to the electrical output of each of the first pixels. The second X-ray detector includes a linear array of second pixels, each of which produces an electrical output in response to the incident X-rays in a second range of energies, broader than the first range of energies. The second X-ray detector also includes a circuit that generates a second electrical signal in response to the electrical output of each of the second pixels. 12 figs.

  10. Images of the laser entrance hole from the static x-ray imager at NIF.

    Science.gov (United States)

    Schneider, M B; Jones, O S; Meezan, N B; Milovich, J L; Town, R P; Alvarez, S S; Beeler, R G; Bradley, D K; Celeste, J R; Dixit, S N; Edwards, M J; Haugh, M J; Kalantar, D H; Kline, J L; Kyrala, G A; Landen, O L; MacGowan, B J; Michel, P; Moody, J D; Oberhelman, S K; Piston, K W; Pivovaroff, M J; Suter, L J; Teruya, A T; Thomas, C A; Vernon, S P; Warrick, A L; Widmann, K; Wood, R D; Young, B K

    2010-10-01

    The static x-ray imager at the National Ignition Facility is a pinhole camera using a CCD detector to obtain images of Hohlraum wall x-ray drive illumination patterns seen through the laser entrance hole (LEH). Carefully chosen filters, combined with the CCD response, allow recording images in the x-ray range of 3-5 keV with 60 μm spatial resolution. The routines used to obtain the apparent size of the backlit LEH and the location and intensity of beam spots are discussed and compared to predictions. A new soft x-ray channel centered at 870 eV (near the x-ray peak of a 300 eV temperature ignition Hohlraum) is discussed.

  11. Automatic medical X-ray image classification using annotation.

    Science.gov (United States)

    Zare, Mohammad Reza; Mueen, Ahmed; Seng, Woo Chaw

    2014-02-01

    The demand for automatically classification of medical X-ray images is rising faster than ever. In this paper, an approach is presented to gain high accuracy rate for those classes of medical database with high ratio of intraclass variability and interclass similarities. The classification framework was constructed via annotation using the following three techniques: annotation by binary classification, annotation by probabilistic latent semantic analysis, and annotation using top similar images. Next, final annotation was constructed by applying ranking similarity on annotated keywords made by each technique. The final annotation keywords were then divided into three levels according to the body region, specific bone structure in body region as well as imaging direction. Different weights were given to each level of the keywords; they are then used to calculate the weightage for each category of medical images based on their ground truth annotation. The weightage computed from the generated annotation of query image was compared with the weightage of each category of medical images, and then the query image would be assigned to the category with closest weightage to the query image. The average accuracy rate reported is 87.5 %.

  12. Development of x-ray microcalorimeter imaging spectrometers for the X-ray Surveyor mission concept

    Science.gov (United States)

    Bandler, Simon R.; Adams, Joseph S.; Chervenak, James A.; Datesman, Aaron M.; Eckart, Megan E.; Finkbeiner, Fred M.; Kelley, Richard L.; Kilbourne, Caroline A.; Betancourt-Martinez, Gabriele; Miniussi, Antoine R.; Porter, Frederick S.; Sadleir, John E.; Sakai, Kazuhiro; Smith, Stephen J.; Stevenson, Thomas R.; Wakeham, Nicholas A.; Wassell, Edward J.; Yoon, Wonsik; Becker, Dan; Bennett, Douglas; Doriese, William B.; Fowler, Joseph W.; Gard, Johnathan D.; Hilton, Gene C.; Mates, Benjamin; Morgan, Kelsey M.; Reintsema, Carl D.; Swetz, Daniel; Ullom, Joel N.; Chaudhuri, Saptarshi; Irwin, Kent D.; Lee, Sang-Jun; Vikhlinin, Alexey

    2016-07-01

    Four astrophysics missions are currently being studied by NASA as candidate large missions to be chosen in the 2020 astrophysics decadal survey.1 One of these missions is the "X-Ray Surveyor" (XRS), and possible configurations of this mission are currently under study by a science and technology definition team (STDT). One of the key instruments under study is an X-ray microcalorimeter, and the requirements for such an instrument are currently under discussion. In this paper we review some different detector options that exist for this instrument, and discuss what array formats might be possible. We have developed one design option that utilizes either transition-edge sensor (TES) or magnetically coupled calorimeters (MCC) in pixel array-sizes approaching 100 kilo-pixels. To reduce the number of sensors read out to a plausible scale, we have assumed detector geometries in which a thermal sensor such a TES or MCC can read out a sub-array of 20-25 individual 1" pixels. In this paper we describe the development status of these detectors, and also discuss the different options that exist for reading out the very large number of pixels.

  13. Electron cyclotron resonance ion source plasma characterization by X-ray spectroscopy and X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mascali, David, E-mail: davidmascali@lns.infn.it; Castro, Giuseppe; Celona, Luigi; Neri, Lorenzo; Gammino, Santo [INFN–Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Biri, Sándor; Rácz, Richárd; Pálinkás, József [Institute for Nuclear Research (Atomki), Hungarian Academy of Sciences, Bem tér 18/c, H-4026 Debrecen (Hungary); Caliri, Claudia [INFN–Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Università degli Studi di Catania, Dip.to di Fisica e Astronomia, via Santa Sofia 64, 95123 Catania (Italy); Romano, Francesco Paolo [INFN–Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); CNR, Istituto per i Beni Archeologici e Monumentali, Via Biblioteca 4, 95124 Catania (Italy); Torrisi, Giuseppe [INFN–Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Università Mediterranea di Reggio Calabria, DIIES, Via Graziella, I-89100 Reggio Calabria (Italy)

    2016-02-15

    An experimental campaign aiming to investigate electron cyclotron resonance (ECR) plasma X-ray emission has been recently carried out at the ECRISs—Electron Cyclotron Resonance Ion Sources laboratory of Atomki based on a collaboration between the Debrecen and Catania ECR teams. In a first series, the X-ray spectroscopy was performed through silicon drift detectors and high purity germanium detectors, characterizing the volumetric plasma emission. The on-purpose developed collimation system was suitable for direct plasma density evaluation, performed “on-line” during beam extraction and charge state distribution characterization. A campaign for correlating the plasma density and temperature with the output charge states and the beam intensity for different pumping wave frequencies, different magnetic field profiles, and single-gas/gas-mixing configurations was carried out. The results reveal a surprisingly very good agreement between warm-electron density fluctuations, output beam currents, and the calculated electromagnetic modal density of the plasma chamber. A charge-coupled device camera coupled to a small pin-hole allowing X-ray imaging was installed and numerous X-ray photos were taken in order to study the peculiarities of the ECRIS plasma structure.

  14. Single molecule imaging with longer x-ray laser pulses

    CERN Document Server

    Martin, Andrew V; Caleman, Carl; Quiney, Harry M

    2015-01-01

    In serial femtosecond crystallography, x-ray laser pulses do not need to outrun all radiation damage processes because Bragg diffraction exceeds the damage-induced background scattering for longer pulses ($\\sim$ 50--100 fs). This is due to a "self-gating pulse" effect whereby damage terminates Bragg diffraction prior to the pulse completing its passage through the sample, as if that diffraction were produced by a shorter pulse of equal fluence. We show here that a similar gating effect applies to single molecule diffraction with respect to spatially uncorrelated damage processes like ionization and ion diffusion. The effect is clearly seen in calculations of the diffraction contrast, by calculating the diffraction of average structure separately to the diffraction from statistical fluctuations of the structure due to damage ("damage noise"). Our results suggest that sub-nanometer single molecule imaging with longer pulses, like those produced at currently operating facilities, should not yet be ruled out. The...

  15. Imaging properties of Wolter I type x-ray telescopes.

    Science.gov (United States)

    Werner, W

    1977-03-01

    By ray-tracing methods we have investigated various configurations of Wolter I type x-ray telescopes. For the criterion of image quality the shape of the line spread function has been chosen. The angular resolution we find herewith in a large region of the basic parameters appears to be more than three times higher than results from the rms blur circle criterion. We have concluded that in most cases of practical interest the paraboloid-hyperboloid combination has to be preferred to the Schwarzschild system. In all cases it is possible to find a solution giving an extra improvement of the angular resolution with a factor between,2 and 4 when we describe the mirror shapes with polynomials.

  16. XIPE: the X-ray imaging polarimetry explorer

    Science.gov (United States)

    Soffitta, Paolo; Barcons, Xavier; Bellazzini, Ronaldo; Braga, João; Costa, Enrico; Fraser, George W.; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; Poutanen, Juri; Reglero, Victor; Santangelo, Andrea; Sunyaev, Rashid A.; Tagliaferri, Gianpiero; Weisskopf, Martin; Aloisio, Roberto; Amato, Elena; Attiná, Primo; Axelsson, Magnus; Baldini, Luca; Basso, Stefano; Bianchi, Stefano; Blasi, Pasquale; Bregeon, Johan; Brez, Alessandro; Bucciantini, Niccoló; Burderi, Luciano; Burwitz, Vadim; Casella, Piergiorgio; Churazov, Eugene; Civitani, Marta; Covino, Stefano; Curado da Silva, Rui Miguel; Cusumano, Giancarlo; Dadina, Mauro; D'Amico, Flavio; De Rosa, Alessandra; Di Cosimo, Sergio; Di Persio, Giuseppe; Di Salvo, Tiziana; Dovciak, Michal; Elsner, Ronald; Eyles, Chris J.; Fabian, Andrew C.; Fabiani, Sergio; Feng, Hua; Giarrusso, Salvatore; Goosmann, René W.; Grandi, Paola; Grosso, Nicolas; Israel, Gianluca; Jackson, Miranda; Kaaret, Philip; Karas, Vladimir; Kuss, Michael; Lai, Dong; Rosa, Giovanni La; Larsson, Josefin; Larsson, Stefan; Latronico, Luca; Maggio, Antonio; Maia, Jorge; Marin, Frédéric; Massai, Marco Maria; Mineo, Teresa; Minuti, Massimo; Moretti, Elena; Muleri, Fabio; O'Dell, Stephen L.; Pareschi, Giovanni; Peres, Giovanni; Pesce, Melissa; Petrucci, Pierre-Olivier; Pinchera, Michele; Porquet, Delphine; Ramsey, Brian; Rea, Nanda; Reale, Fabio; Rodrigo, Juana Maria; Różańska, Agata; Rubini, Alda; Rudawy, Pawel; Ryde, Felix; Salvati, Marco; de Santiago, Valdivino Alexandre; Sazonov, Sergey; Sgró, Carmelo; Silver, Eric; Spandre, Gloria; Spiga, Daniele; Stella, Luigi; Tamagawa, Toru; Tamborra, Francesco; Tavecchio, Fabrizio; Teixeira Dias, Teresa; van Adelsberg, Matthew; Wu, Kinwah; Zane, Silvia

    2013-12-01

    Abstract X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017. The proposal was, unfortunately, not selected. To be compliant with this schedule, we designed the payload mostly with existing items. The XIPE proposal takes advantage of the completed phase A of POLARIX for an ASI small mission program that was cancelled, but is different in many aspects: the detectors, the presence of a solar flare polarimeter and photometer and the use of a light platform derived by a mass production for a cluster of satellites. XIPE is composed of two out of the three existing JET-X telescopes with two Gas Pixel Detectors (GPD) filled with a He-DME mixture at their focus. Two additional GPDs filled with a 3-bar Ar-DME mixture always face the Sun to detect polarization from solar flares. The Minimum Detectable Polarization of a 1 mCrab source reaches 14 % in the 2-10 keV band in 105 s for pointed observations, and 0.6 % for an X10 class solar flare in the 15-35 keV energy band. The imaging capability is 24 arcsec Half Energy Width (HEW) in a Field of

  17. Structured scintillators for X-ray imaging with micrometre resolution

    DEFF Research Database (Denmark)

    Olsen, Ulrik Lund; Schmidt, Søren; Poulsen, Henning Friis

    2009-01-01

    A 3D X-ray detector for imaging of 30–200 keV photons is described. It comprises a stack of semitransparent structured scintillators, where each scintillator is a regular array of waveguides in silicon, and with pores filled with CsI. The performance of the detector is described theoretically...... and explored in detail through simulations. The resolution of a single screen is shown to be determined only by the pitch, at least up to 100 keV. In comparison to conventional homogenous screens an improvement in efficiency by a factor 5–15 is obtainable. The cross-talk between screens in the 3D detector...... used regular scintillators with similar resolution an efficiency increase by a factor 4 has been found for the structured scintillator....

  18. X-Ray Scatter Correction on Soft Tissue Images for Portable Cone Beam CT

    OpenAIRE

    Sorapong Aootaphao; Saowapak S. Thongvigitmanee; Jartuwat Rajruangrabin; Chalinee Thanasupsombat; Tanapon Srivongsa; Pairash Thajchayapong

    2016-01-01

    Soft tissue images from portable cone beam computed tomography (CBCT) scanners can be used for diagnosis and detection of tumor, cancer, intracerebral hemorrhage, and so forth. Due to large field of view, X-ray scattering which is the main cause of artifacts degrades image quality, such as cupping artifacts, CT number inaccuracy, and low contrast, especially on soft tissue images. In this work, we propose the X-ray scatter correction method for improving soft tissue images. The X-ray scatter ...

  19. The Advanced X-ray Spectroscopy and Imaging Observatory (AXSIO)

    Science.gov (United States)

    White, Nicholas E.; Bookbinder, Jay; Petre, Robert; Smith, Randall; Ptak, Andrew; Tananbaum, Harvey; Garcia, Michael

    2012-01-01

    Following recommendations from the 2010 "New Worlds, New Horizons" (NWNH) report, the Advanced X-ray Spectroscopy and Imaging Observatory (AXSIO) concept streamlines the International X-ray Observatory (IXO) mission to concentrate on the science objectives that are enabled by high-resolution spectroscopic capabilities. AXSIO will trace orbits close to the event horizon of black holes, measure black hole spin for tens of supermassive black holes (SMBH), use spectroscopy to characterize outflows and the environment of AGN during their peak activity, observe 5MBH out to redshift z=6, map bulk motions and turbulence in galaxy clusters, find the missing baryons in the cosmic web using background quasars, and observe the process of cosmic feedback where black holes and supernovae inject energy on galactic and intergalactic scales. These measurements are enabled by a 0.9 sq m collecting area at 1.25 keV, a micro calorimeter array providing high-resolution spectroscopic imaging and a deployable high efficiency grating spectrometer. AXSIO delivers a 30-fold increase in effective area for high resolution spectroscopy. The key simplifications are guided by recommendations in the NWNH panel report include a reduction in focal length from 20m to 10m, eliminating the extendable optical bench, and a reduction in the instrument complement from six to two, avoiding a movable instrument platform. A focus on spectroscopic science allows the spatial resolution requirement to be relaxed to 10 arc sec (with a 5 arc sec goal). These simplifications decrease the total mission cost to under the $2B cost to NASA recommended by NWNH. AXSIO will be available to the entire astronomical community with observing allocations based on peer-review.

  20. Three-dimensional phase-contrast X-ray microtomography with scanning-imaging X-ray microscope optics.

    Science.gov (United States)

    Takeuchi, Akihisa; Uesugi, Kentaro; Suzuki, Yoshio

    2013-09-01

    A three-dimensional (3D) X-ray tomographic micro-imaging system has been developed. The optical system is based on a scanning-imaging X-ray microscope (SIXM) optics, which is a hybrid system consisting of a scanning microscope optics with a one-dimensional (1D) focusing (line-focusing) device and an imaging microscope optics with a 1D objective. In the SIXM system, each 1D dataset of a two-dimensional (2D) image is recorded independently. An object is illuminated with a line-focused beam. Positional information of the region illuminated by the line-focused beam is recorded with the 1D imaging microscope optics as line-profile data. By scanning the object with the line focus, 2D image data are obtained. In the same manner as for a scanning microscope optics with a multi-pixel detector, imaging modes such as phase contrast and absorption contrast can be arbitrarily configured after the image data acquisition. By combining a tomographic scan method and the SIXM system, quantitative 3D imaging is performed. Results of a feasibility study of the SIXM for 3D imaging are shown.

  1. Coherent X-Ray Diffraction Imaging of Chloroplasts from Cyanidioschyzon merolae by Using X-Ray Free Electron Laser.

    Science.gov (United States)

    Takayama, Yuki; Inui, Yayoi; Sekiguchi, Yuki; Kobayashi, Amane; Oroguchi, Tomotaka; Yamamoto, Masaki; Matsunaga, Sachihiro; Nakasako, Masayoshi

    2015-07-01

    Coherent X-ray diffraction imaging (CXDI) is a lens-less technique for visualizing the structures of non-crystalline particles with the dimensions of submicrometer to micrometer at a resolution of several tens of nanometers. We conducted cryogenic CXDI experiments at 66 K to visualize the internal structures of frozen-hydrated chloroplasts of Cyanidioschyzon merolae using X-ray free electron laser (XFEL) as a coherent X-ray source. Chloroplast dispersed specimen disks at a number density of 7/(10×10 µm(2)) were flash-cooled with liquid ethane without staining, sectioning or chemical labeling. Chloroplasts are destroyed at atomic level immediately after the diffraction by XFEL pulses. Thus, diffraction patterns with a good signal-to-noise ratio from single chloroplasts were selected from many diffraction patterns collected through scanning specimen disks to provide fresh specimens into the irradiation area. The electron density maps of single chloroplasts projected along the direction of the incident X-ray beam were reconstructed by using the iterative phase-retrieval method and multivariate analyses. The electron density map at a resolution of 70 nm appeared as a C-shape. In addition, the fluorescence image of proteins stained with Flamingo™ dye also appeared as a C-shape as did the autofluorescence from Chl. The similar images suggest that the thylakoid membranes with an abundance of proteins distribute along the outer membranes of chloroplasts. To confirm the present results statistically, a number of projection structures must be accumulated through high-throughput data collection in the near future. Based on the results, we discuss the feasibility of XFEL-CXDI experiments in the structural analyses of cellular organelles.

  2. ASSESSMENT OF RESTORATION METHODS OF X-RAY IMAGES WITH EMPHASIS ON MEDICAL PHOTOGRAMMETRIC USAGE

    Directory of Open Access Journals (Sweden)

    S. Hosseinian

    2016-06-01

    Full Text Available Nowadays, various medical X-ray imaging methods such as digital radiography, computed tomography and fluoroscopy are used as important tools in diagnostic and operative processes especially in the computer and robotic assisted surgeries. The procedures of extracting information from these images require appropriate deblurring and denoising processes on the pre- and intra-operative images in order to obtain more accurate information. This issue becomes more considerable when the X-ray images are planned to be employed in the photogrammetric processes for 3D reconstruction from multi-view X-ray images since, accurate data should be extracted from images for 3D modelling and the quality of X-ray images affects directly on the results of the algorithms. For restoration of X-ray images, it is essential to consider the nature and characteristics of these kinds of images. X-ray images exhibit severe quantum noise due to limited X-ray photons involved. The assumptions of Gaussian modelling are not appropriate for photon-limited images such as X-ray images, because of the nature of signal-dependant quantum noise. These images are generally modelled by Poisson distribution which is the most common model for low-intensity imaging. In this paper, existing methods are evaluated. For this purpose, after demonstrating the properties of medical X-ray images, the more efficient and recommended methods for restoration of X-ray images would be described and assessed. After explaining these approaches, they are implemented on samples from different kinds of X-ray images. By considering the results, it is concluded that using PURE-LET, provides more effective and efficient denoising than other examined methods in this research.

  3. Assessment of Restoration Methods of X-Ray Images with Emphasis on Medical Photogrammetric Usage

    Science.gov (United States)

    Hosseinian, S.; Arefi, H.

    2016-06-01

    Nowadays, various medical X-ray imaging methods such as digital radiography, computed tomography and fluoroscopy are used as important tools in diagnostic and operative processes especially in the computer and robotic assisted surgeries. The procedures of extracting information from these images require appropriate deblurring and denoising processes on the pre- and intra-operative images in order to obtain more accurate information. This issue becomes more considerable when the X-ray images are planned to be employed in the photogrammetric processes for 3D reconstruction from multi-view X-ray images since, accurate data should be extracted from images for 3D modelling and the quality of X-ray images affects directly on the results of the algorithms. For restoration of X-ray images, it is essential to consider the nature and characteristics of these kinds of images. X-ray images exhibit severe quantum noise due to limited X-ray photons involved. The assumptions of Gaussian modelling are not appropriate for photon-limited images such as X-ray images, because of the nature of signal-dependant quantum noise. These images are generally modelled by Poisson distribution which is the most common model for low-intensity imaging. In this paper, existing methods are evaluated. For this purpose, after demonstrating the properties of medical X-ray images, the more efficient and recommended methods for restoration of X-ray images would be described and assessed. After explaining these approaches, they are implemented on samples from different kinds of X-ray images. By considering the results, it is concluded that using PURE-LET, provides more effective and efficient denoising than other examined methods in this research.

  4. Fourier domain image fusion for differential X-ray phase-contrast breast imaging.

    Science.gov (United States)

    Coello, Eduardo; Sperl, Jonathan I; Bequé, Dirk; Benz, Tobias; Scherer, Kai; Herzen, Julia; Sztrókay-Gaul, Anikó; Hellerhoff, Karin; Pfeiffer, Franz; Cozzini, Cristina; Grandl, Susanne

    2017-04-01

    X-Ray Phase-Contrast (XPC) imaging is a novel technology with a great potential for applications in clinical practice, with breast imaging being of special interest. This work introduces an intuitive methodology to combine and visualize relevant diagnostic features, present in the X-ray attenuation, phase shift and scattering information retrieved in XPC imaging, using a Fourier domain fusion algorithm. The method allows to present complementary information from the three acquired signals in one single image, minimizing the noise component and maintaining visual similarity to a conventional X-ray image, but with noticeable enhancement in diagnostic features, details and resolution. Radiologists experienced in mammography applied the image fusion method to XPC measurements of mastectomy samples and evaluated the feature content of each input and the fused image. This assessment validated that the combination of all the relevant diagnostic features, contained in the XPC images, was present in the fused image as well.

  5. A computer code to simulate X-ray imaging techniques

    Energy Technology Data Exchange (ETDEWEB)

    Duvauchelle, Philippe E-mail: philippe.duvauchelle@insa-lyon.fr; Freud, Nicolas; Kaftandjian, Valerie; Babot, Daniel

    2000-09-01

    A computer code was developed to simulate the operation of radiographic, radioscopic or tomographic devices. The simulation is based on ray-tracing techniques and on the X-ray attenuation law. The use of computer-aided drawing (CAD) models enables simulations to be carried out with complex three-dimensional (3D) objects and the geometry of every component of the imaging chain, from the source to the detector, can be defined. Geometric unsharpness, for example, can be easily taken into account, even in complex configurations. Automatic translations or rotations of the object can be performed to simulate radioscopic or tomographic image acquisition. Simulations can be carried out with monochromatic or polychromatic beam spectra. This feature enables, for example, the beam hardening phenomenon to be dealt with or dual energy imaging techniques to be studied. The simulation principle is completely deterministic and consequently the computed images present no photon noise. Nevertheless, the variance of the signal associated with each pixel of the detector can be determined, which enables contrast-to-noise ratio (CNR) maps to be computed, in order to predict quantitatively the detectability of defects in the inspected object. The CNR is a relevant indicator for optimizing the experimental parameters. This paper provides several examples of simulated images that illustrate some of the rich possibilities offered by our software. Depending on the simulation type, the computation time order of magnitude can vary from 0.1 s (simple radiographic projection) up to several hours (3D tomography) on a PC, with a 400 MHz microprocessor. Our simulation tool proves to be useful in developing new specific applications, in choosing the most suitable components when designing a new testing chain, and in saving time by reducing the number of experimental tests.

  6. X-ray backscatter imaging of nuclear materials

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, Jeffrey Allen; Gunning, John E; Hollenbach, Daniel F; Ott, Larry J; Shedlock, Daniel

    2014-09-30

    The energy of an X-ray beam and critical depth are selected to detect structural discontinuities in a material having an atomic number Z of 57 or greater. The critical depth is selected by adjusting the geometry of a collimator that blocks backscattered radiation so that backscattered X-ray originating from a depth less than the critical depth is not detected. Structures of Lanthanides and Actinides, including nuclear fuel rod materials, can be inspected for structural discontinuities such as gaps, cracks, and chipping employing the backscattered X-ray.

  7. X-ray phase imaging with a grating interferometer.

    Science.gov (United States)

    Weitkamp, Timm; Diaz, Ana; David, Christian; Pfeiffer, Franz; Stampanoni, Marco; Cloetens, Peter; Ziegler, Eric

    2005-08-08

    Using a high-efficiency grating interferometer for hard X rays (10-30 keV) and a phase-stepping technique, separate radiographs of the phase and absorption profiles of bulk samples can be obtained from a single set of measurements. Tomographic reconstruction yields quantitative three-dimensional maps of the X-ray refractive index, with a spatial resolution down to a few microns. The method is mechanically robust, requires little spatial coherence and monochromaticity, and can be scaled up to large fields of view, with a detector of correspondingly moderate spatial resolution. These are important prerequisites for use with laboratory X-ray sources.

  8. Magnetic resonance imaging of the central nervous system. Comparison with X-ray CT

    Energy Technology Data Exchange (ETDEWEB)

    Kajima, Toshio; Kagawa, Yoshihiro; Katsuta, Shizutomo.

    1987-06-01

    Magnetic resonance imaging (MRI) and X-ray computed tomography (X-ray CT) have been performed in 169 consecutive patients with central nervous system diseases. The findings from the two methods were compared for the capacity to defect lesions. Magnetic resonance imaging was more sensitive than or equivalent to X-ray CT in detecting lesions - especially detecting. Arnold-Chiari malformation, syringomyelia, spinal cord injury, and pituitary adenoma - in 158 patients (94 %). In six patients (10 %), lesion detection was possible only by MRI. Magnetic resonance imaging was inferior to X-ray CT in 11 patients (7 %) in detecting calcified lesions, meningioma, and cavernous hemangioma. (Namekawa, K.).

  9. Medical X-Ray Image Enhancement Based on Kramer's PDE Model

    Institute of Scientific and Technical Information of China (English)

    Yan-Fei Zhao; Qing-Wei Gao; De-Xiang Zhang; Yi-Xiang Lu

    2007-01-01

    The purpose of this study is to present an application of a novel enhancement technique for enhancing medical images generated from X-rays. The method presented in this study is based on a nonlinear partial differential equation (PDE) model, Kramer's PDE model. The usefulness of this method is investigated by experimental results. We apply this method to a medical X-ray image. For comparison, the X-ray image is also processed using classic Perona-Malik PDE model and Catte PDE model. Although the Perona-Malik model and Catte PDE model could also enhance the image, the quality of the enhanced images is considerably inferior compared with the enhanced image using Kramer's PDE model. The study suggests that the Kramer's PDE model is capable of enhancing medical X-ray images, which will make the X-ray images more reliable.

  10. X-MIME: An Imaging X-ray Spectrometer for Detailed Study of Jupiter's Icy Moons and the Planet's X-ray Aurora

    Science.gov (United States)

    Elsner, R. F.; Ramsey, B. D.; Waite, J. H.; Rehak, P.; Johnson, R. E.; Cooper, J. F.; Swartz, D. A.

    2004-01-01

    Remote observations with the Chandra X-ray Observatory and the XMM-Newton Observatory have shown that the Jovian system is a source of x-rays with a rich and complicated structure. The planet's polar auroral zones and its disk are powerful sources of x-ray emission. Chandra observations revealed x-ray emission from the Io Plasma Torus and from the Galilean moons Io, Europa, and possibly Ganymede. The emission from these moons is certainly due to bombardment of their surfaces of highly energetic protons, oxygen and sulfur ions from the region near the Torus exciting atoms in their surfaces and leading to fluorescent x-ray emission lines. Although the x-ray emission from the Galilean moons is faint when observed from Earth orbit, an imaging x-ray spectrometer in orbit around these moons, operating at 200 eV and above with 150 eV energy resolution, would provide a detailed mapping (down to 40 m spatial resolution) of the elemental composition in their surfaces. Such maps would provide important constraints on formation and evolution scenarios for the surfaces of these moons. Here we describe the characteristics of X-MIME, an imaging x-ray spectrometer under going a feasibility study for the JIMO mission, with the ultimate goal of providing unprecedented x-ray studies of the elemental composition of the surfaces of Jupiter's icy moons and Io, as well as of Jupiter's auroral x-ray emission.

  11. High-resolution X-ray imaging in fast ignition experiment using Gekko and LFEX lasers

    Directory of Open Access Journals (Sweden)

    Koga M.

    2013-11-01

    Full Text Available We improved diagnostic instruments to measure X-ray images in a hard X-ray harsh environment and succeeded in obtaining clear images with X-ray framing camera and X-ray streak camera in fast ignition experiment conducted in 2011 (FG-02 Experimental Campaign. We found that high-energy X-ray signals could be used as an indicator of the LFEX laser injection time relative to the imploded core. The LFEX laser injection time was estimated with better than 10 ps accuracy. Time-resolved 2D X-ray images suggested that shapes and motions of imploded core plasmas were improved by changing the configuration of the implosion lasers.

  12. Low Power X-Ray Photon Resolving Imaging Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Instruments employing X-ray detection are countless, in different sectors from medicine to industry and from basic to applied science. Given this importance, and...

  13. Federated repositories of X-ray diffraction images.

    Science.gov (United States)

    Androulakis, Steve; Schmidberger, Jason; Bate, Mark A; DeGori, Ross; Beitz, Anthony; Keong, Cyrus; Cameron, Bob; McGowan, Sheena; Porter, Corrine J; Harrison, Andrew; Hunter, Jane; Martin, Jennifer L; Kobe, Bostjan; Dobson, Renwick C J; Parker, Michael W; Whisstock, James C; Gray, Joan; Treloar, Andrew; Groenewegen, David; Dickson, Neil; Buckle, Ashley M

    2008-07-01

    There is a pressing need for the archiving and curation of raw X-ray diffraction data. This information is critical for validation, methods development and improvement of archived structures. However, the relatively large size of these data sets has presented challenges for storage in a single worldwide repository such as the Protein Data Bank archive. This problem can be avoided by using a federated approach, where each institution utilizes its institutional repository for storage, with a discovery service overlaid. Institutional repositories are relatively stable and adequately funded, ensuring persistence. Here, a simple repository solution is described, utilizing Fedora open-source database software and data-annotation and deposition tools that can be deployed at any site cheaply and easily. Data sets and associated metadata from federated repositories are given a unique and persistent handle, providing a simple mechanism for search and retrieval via web interfaces. In addition to ensuring that valuable data is not lost, the provision of raw data has several uses for the crystallographic community. Most importantly, structure determination can only be truly repeated or verified when the raw data are available. Moreover, the availability of raw data is extremely useful for the development of improved methods of image analysis and data processing.

  14. Dosimetry in x-ray-based breast imaging

    Science.gov (United States)

    Dance, David R.; Sechopoulos, Ioannis

    2016-10-01

    The estimation of the mean glandular dose to the breast (MGD) for x-ray based imaging modalities forms an essential part of quality control and is needed for risk estimation and for system design and optimisation. This review considers the development of methods for estimating the MGD for mammography, digital breast tomosynthesis (DBT) and dedicated breast CT (DBCT). Almost all of the methodology used employs Monte Carlo calculated conversion factors to relate the measurable quantity, generally the incident air kerma, to the MGD. After a review of the size and composition of the female breast, the various mathematical models used are discussed, with particular emphasis on models for mammography. These range from simple geometrical shapes, to the more recent complex models based on patient DBCT examinations. The possibility of patient-specific dose estimates is considered as well as special diagnostic views and the effect of breast implants. Calculations using the complex models show that the MGD for mammography is overestimated by about 30% when the simple models are used. The design and uses of breast-simulating test phantoms for measuring incident air kerma are outlined and comparisons made between patient and phantom-based dose estimates. The most widely used national and international dosimetry protocols for mammography are based on different simple geometrical models of the breast, and harmonisation of these protocols using more complex breast models is desirable.

  15. X-ray image segmentation for vertebral mobility analysis

    Energy Technology Data Exchange (ETDEWEB)

    Benjelloun, Mohammed; Mahmoudi, Said [Computer Science Department, Faculty of Engineering of Mons, Mons (Belgium)

    2008-04-15

    The goal of this work is to extract the parameters determining vertebral motion and its variation during flexion-extension movements using a computer vision tool for estimating and analyzing vertebral mobility. To compute vertebral body motion parameters we propose a comparative study between two segmentation methods proposed and applied to lateral X-ray images of the cervical spine. The two vertebra contour detection methods include (1) a discrete dynamic contour model (DDCM) and (2) a template matching process associated with a polar signature system. These two methods not only enable vertebra segmentation but also extract parameters that can be used to evaluate vertebral mobility. Lateral cervical spine views including 100 views in flexion, extension and neutral orientations were available for evaluation. Vertebral body motion was evaluated by human observers and using automatic methods. The results provided by the automated approaches were consistent with manual measures obtained by 15 human observers. The automated techniques provide acceptable results for the assessment of vertebral body mobility in flexion and extension on lateral views of the cervical spine. (orig.)

  16. Evaluation of controlled-drift detectors in X-ray spectroscopic imaging applications.

    Science.gov (United States)

    Castoldi, Andrea; Guazzoni, Chiara; Ozkan, Cigdem; Vedani, Giorgio; Hartmann, Robert; Bjeoumikhov, Aniouar

    2009-06-01

    A detector that looks promising for advanced imaging modalities--such as X-ray absorption contrast imaging, X-ray fluorescence imaging, and diffraction-enhanced imaging--is the controlled-drift detector (CDD). The CDD is a novel two-dimensional X-ray imager with energy resolving capability of spectroscopic quality. It is built on a fully depleted silicon wafer and features fast readout while being operated at or near room temperature. The use of CDDs in the aforementioned applications allows translating these techniques from synchrotron-based experiments to laboratory-size experiments using polychromatic X-ray generators. We have built a dedicated and versatile detection module based on a 36 mm2 CDD chip featuring pixels of 180 x 180 microm 2, and we evaluated the system performance in different X-ray imaging applications both with synchrotron-based experiments and in the laboratory environment.

  17. Energy-resolved X-ray detectors: the future of diagnostic imaging

    Directory of Open Access Journals (Sweden)

    Pacella D

    2015-01-01

    Full Text Available Danilo Pacella ENEA-Frascati, Rome, Italy Abstract: This paper presents recent progress in the field of X-ray detectors, which could play a role in medical imaging in the near future, with special attention to the new generation of complementary metal-oxide semiconductor (C-MOS imagers, working in photon counting, that opened the way to the energy-resolved X-ray imaging. A brief description of the detectors used so far in medical imaging (photographic films, imaging plates, flat panel detectors, together with the most relevant imaging quality parameters, shows differences between, and advantages of these new C-MOS imagers. X-ray energy-resolved imaging is very attractive not only for the increase of contrast but even for the capability of detecting the nature and composition of the material or tissue to be investigated. Since the X-ray absorption coefficients of the different parts or organs of the patient (object are strongly dependent on the X-ray photon energy, this multienergy ("colored" X-ray imaging could increase enormously the probing capabilities. While dual-energy imaging is now a reality in medical practice, multienergy is still in its early stage, but a promising research activity. Based on this new technique of color X-ray imaging, the entire scheme of source–object–detector could be revised in the future, optimizing spectrum and detector to the nature and composition of the target to be investigated. In this view, a transition to a set of monoenergetic X-ray lines, suitably chosen in energy and intensity, could be envisaged, instead of the present continuous spectra. Keywords: X-ray detectors, X-ray medical imaging, C-MOS imagers, dual and multienergy CT

  18. X-ray phase contrast imaging of biological specimens with tabletop synchrotron radiation

    CERN Document Server

    Kneip, S; Dollar, F; Bloom, M S; Chvykov, V; Kalintchenko, G; Krushelnick, K; Maksimchuk, A; Mangles, S P D; Matsuoka, T; Najmudin, Z; Palmer, C A J; Schreiber, J; Schumaker, W; Thomas, A G R; Yanovsky, V

    2011-01-01

    Since their discovery in 1896, x-rays have had a profound impact on science, medicine and technology. Here we show that the x-rays from a novel tabletop source of bright coherent synchrotron radiation can be applied to phase contrast imaging of biological specimens, yielding superior image quality and avoiding the need for scarce or expensive conventional sources.

  19. Attenuation correction of myocardial SPECT images with X-ray CT. Effects of registration errors between X-ray CT and SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Yasuyuki; Murase, Kenya [Osaka Univ., Suita (Japan). Graduate School of Medicine; Higashino, Hiroshi [Ehime Prefectural Imabari Hospital (Japan); Mochizuki, Teruhito [Ehime Univ., Matsuyama (Japan). School of Medicine; Motomura, Nobutoku [Toshiba Corp., Otawara, Tochigi (Japan). Medical Engineering Lab.

    2002-09-01

    Attenuation correction with an X-ray CT image is a new method to correct attenuation on SPECT imaging, but the effect of the registration errors between CT and SPECT images is unclear. In this study, we investigated the effects of the registration errors on myocardial SPECT, analyzing data from a phantom and a human volunteer. Registerion (fusion) of the X-ray CT and SPECT images was done with standard packaged software in three dimensional fashion, by using linked transaxial, coronal and sagittal images. In the phantom study, and X-ray CT image was shifted 1 to 3 pixels on the x, y and z axes, and rotated 6 degrees clockwise. Attenuation correction maps generated from each misaligned X-ray CT image were used to reconstruct misaligned SPECT images of the phantom filled with {sup 201}Tl. In a human volunteer, X-ray CT was acquired in different conditions (during inspiration vs. expiration). CT values were transferred to an attenuation constant by using straight lines; an attenuation constant of 0/cm in the air (CT value=-1,000 HU) and that of 0.150/cm in water (CT value=0 HU). For comparison, attenuation correction with transmission CT (TCT) data and an external {gamma}-ray source ({sup 99m}Tc) was also applied to reconstruct SPECT images. Simulated breast attenuation with a breast attachment, and inferior wall attenuation were properly corrected by means of the attenuation correction map generated from X-ray CT. As pixel shift increased, deviation of the SPECT images increased in misaligned images in the phantom study. In the human study, SPECT images were affected by the scan conditions of the X-ray CT. Attenuation correction of myocardial SPECT with an X-ray CT image is a simple and potentially beneficial method for clinical use, but accurate registration of the X-ray CT to SPECT image is essential for satisfactory attenuation correction. (author)

  20. Magnetic soft x-ray microscopy-imaging fast spin dynamics inmagnetic nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Peter; Kim, Dong-Hyun; Mesler, Brooke L.; Chao, Weilun; Sakdinawat, Anne E.; Anderson, Erik H.

    2007-06-01

    Magnetic soft X-ray microscopy combines 15nm spatial resolution with 70ps time resolution and elemental sensitivity. Fresnel zone plates are used as X-ray optics and X-ray magnetic circular dichroism serves as magnetic contrast mechanism. Thus scientifically interesting and technologically relevant low dimensional nanomagnetic systems can be imaged at fundamental length and ultrafast time scales in a unique way. Studies include magnetization reversal in magnetic multilayers, nanopatterned systems, vortex dynamics in nanoelements and spin current induced phenomena.

  1. A High Resolution X-ray Image of the Jet in M 87

    CERN Document Server

    Marshall, H L; Davis, D S; Perlman, E S; Wise, M; Canizares, C R; Harris, D E

    2001-01-01

    We present the first high resolution X-ray image of the jet in M 87 using the Chandra X-ray Observatory. There is clear structure in the jet and almost all of the optically bright knots are detected individually. The unresolved core is the brightest X-ray feature but is only 2-3 times brighter than knot A (12.3" from the core) and the inner knot HST-1 (1.0" from the core). The X-ray and optical positions of the knots are consistent at the 0.1" level but the X-ray emission from the brightest knot (A) is marginally upstream of the optical emission peak. Detailed Gaussian fits to the X-ray jet one-dimensional profile show distinct X-ray emission that is not associated with specific optical features. The X-ray/optical flux ratio decreases systematically from the core and X-ray emission is not clearly detected beyond 20" from the core. The X-ray spectra of the core and the two brightest knots, HST-1 and A1, are consistent with a simple power law with alpha = 1.46 +/- 0.05, practically ruling out inverse Compton mo...

  2. Long Bone X-ray Image Stitching Using C-arm Motion Estimation

    Science.gov (United States)

    Wang, Lejing; Traub, Joerg; Heining, Sandro Michael; Benhimane, Selim; Euler, Ekkehard; Graumann, Rainer; Navab, Nassir

    In this paper, we propose a novel method to generate panoramic X-ray images intra-operatively by using the previously introduced camera augmented mobile C-arm by Navab et al. [1]. This advanced mobile C-arm system acquires registered X-ray and optical images by construction, which facilitates the generation of panoramic X-ray images based on the motion estimation of the X-ray source. Visual marker tracking is employed to estimate the camera motion and this estimated motion is also applied to the X-ray source. Our proposed method is suitable and practical for intra-operative usage generating panoramic X-ray images without the requirement of a fronto-parallel setup and overlapping X-ray images. The results show that the panoramic X-ray images generated by our method are accurate enough (errors less than 1%) for metric measurements and promise suitability for intra-operative clinical applications in trauma surgery.

  3. Chest X Ray?

    Science.gov (United States)

    ... this page from the NHLBI on Twitter. Chest X Ray A chest x ray is a fast and painless imaging test ... tissue scarring, called fibrosis. Doctors may use chest x rays to see how well certain treatments are ...

  4. X-Rays

    Science.gov (United States)

    X-rays are a type of radiation called electromagnetic waves. X-ray imaging creates pictures of the inside of ... different amounts of radiation. Calcium in bones absorbs x-rays the most, so bones look white. Fat ...

  5. MeV X-ray imaging using plastic scintillating fiber area detectors: a simulation study.

    Science.gov (United States)

    Tang, Shi-Biao; Ma, Qingli; Yin, Zejie; Zhu, Daming

    2008-02-01

    Due to their low cost, flexibility, and convenience for long distance data transfer, plastic scintillating fibers (PSFs) have been increasingly used in building detectors or sensors for detecting various radiations and imaging. In this work, the possibility of using PSF coupled with charge-coupled devices (CCD) to build area detectors for X-ray imaging is studied using a Monte Carlo simulation. The focus is on X-ray imaging with energy from a few 100 keV to about 20 MeV. It is found that the efficiency of PSF in detecting X-ray in this energy range is low. The performance can be improved by coating a PSF with X-ray absorption layers and the MTF of the system is presented. It seems possible to build such area detectors with PSFs for imaging hard X-rays under certain environment.

  6. Chemical imaging analysis of the brain with X-ray methods

    Science.gov (United States)

    Collingwood, Joanna F.; Adams, Freddy

    2017-04-01

    Cells employ various metal and metalloid ions to augment the structure and the function of proteins and to assist with vital biological processes. In the brain they mediate biochemical processes, and disrupted metabolism of metals may be a contributing factor in neurodegenerative disorders. In this tutorial review we will discuss the particular role of X-ray methods for elemental imaging analysis of accumulated metal species and metal-containing compounds in biological materials, in the context of post-mortem brain tissue. X-rays have the advantage that they have a short wavelength and can penetrate through a thick biological sample. Many of the X-ray microscopy techniques that provide the greatest sensitivity and specificity for trace metal concentrations in biological materials are emerging at synchrotron X-ray facilities. Here, the extremely high flux available across a wide range of soft and hard X-rays, combined with state-of-the-art focusing techniques and ultra-sensitive detectors, makes it viable to undertake direct imaging of a number of elements in brain tissue. The different methods for synchrotron imaging of metals in brain tissues at regional, cellular, and sub-cellular spatial resolution are discussed. Methods covered include X-ray fluorescence for elemental imaging, X-ray absorption spectrometry for speciation imaging, X-ray diffraction for structural imaging, phase contrast for enhanced contrast imaging and scanning transmission X-ray microscopy for spectromicroscopy. Two- and three-dimensional (confocal and tomographic) imaging methods are considered as well as the correlation of X-ray microscopy with other imaging tools.

  7. Imaging Polarimetry of Six X-Ray Selected Blazars

    Science.gov (United States)

    Ghosh, K. K.; Ramsey, B. D.; Austin, R. A.; Soundararajaperumal, S.

    1998-01-01

    Results of broad band V-filter linear optical polarization measurements of six X-ray selected B L Lac objects (XBLs) are presented. Four of these B L Lac objects (MS0737.9+7441, MS0950.9+4929, MS1458.8+2249 and MS 1534.2+0148) had not been measured before in this band. We have detected strong optical polarization in three B L Lac objects. Analysis of radio through X-ray spectra of these sources confirms that these objects are indeed XBLS. We have also detected several new polarized sources in the fields of these B L Lacs.

  8. Profile reconstruction of grazing-incidence X-ray mirrors from intra-focal X-ray full imaging

    CERN Document Server

    Spiga, D; Bavdaz, M; Burwitz, V; Civitani, M; Citterio, O; Ghigo, M; Hartner, G; Menz, B; Pareschi, G; Proserpio, L; Salmaso, B; Tagliaferri, G; Wille, E

    2015-01-01

    The optics of a number of future X-ray telescopes will have very long focal lengths (10 - 20 m), and will consist of a number of nested/stacked thin, grazing-incidence mirrors. The optical quality characterization of a real mirror can be obtained via profile metrology, and the Point Spread Function of the mirror can be derived via one of the standard computation methods. However, in practical cases it can be difficult to access the optical surfaces of densely stacked mirror shells, after they have been assembled, using the widespread metrological tools. For this reason, the assessment of the imaging resolution of a system of mirrors is better obtained via a direct, full-illumination test in X-rays. If the focus cannot be reached, an intra-focus test can be performed, and the image can be compared with the simulation results based on the metrology, if available. However, until today no quantitative information was extracted from a full-illumination, intra-focal exposure. In this work we show that, if the detec...

  9. Tissue Visualization Using X-Ray Dark-Field Imaging towards Pathological Goal

    Science.gov (United States)

    Ando, Masami; Chikaura, Yoshinori; Endo, Tokiko; Gupta, Rajiv; Huo, Qingkai; Hyodo, Kazuyuki; Ichihara, Shu; Mori, Kensaku; Nakao, Yuki; Ohura, Norihiko; Sunaguchi, Naoki; Sugiyama, Hiroshi; Suzuki, Yoshifumi; Wu, Yanlin; Yuasa, Tetsuya; Xiaowei, Zhang

    2013-03-01

    In XDFI (x-ray dark-field imaging) LAA (Laue-case angle analyzer) simultaneously provides two x-ray images; one corresponds to a FD forward diffracted beam and a separate D diffracted beam. When this is applied to biomedical specimens x-ray images are very high contrast and very high spatial resolution. We constructed XDFI system at the vertical wiggler beamline BL-14C in KEK Photon Factory and performed imaging experiment of breast tissues and an excised human femoral artery. In this paper, we discuss a tissue visualization and pathological goal using 2D, 3D-CT and 2.5D image (tomosynthesis) with XDFI.

  10. First Images from HERO: A Hard-X-Ray Focusing Telescope

    Science.gov (United States)

    Ramsey, Brian D.; Alexander, Cheryl D.; Apple, Jeff A.; Benson, Carl M.; Dietz, Kurtis L.; Elsner, Ronald F.; Engelhaupt, Darell E.; Ghosh, Kajal K.; Kolodziejczak, Jeffery J.; ODell, Stephen L.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    We are developing a balloon-borne hard-x-ray telescope that utilizes grazing incidence optics. Termed HERO, for High-Energy Replicated Optics, the instrument will provide unprecented sensitivity in the hard-x-ray region and will achieve milliCrab-level sensitivity in a typical 3-hour balloon-flight observation and 50 microCrab sensitivity on ultra-long-duration flights. A recent proof-of-concept flight, featuring a small number of mirror shells captured the first focused hard-x-ray images of galactic x-ray sources. Full details of the payload, its expected future performance and its recent measurements are provided.

  11. A Novel Feature Extraction Scheme for Medical X-Ray Images

    OpenAIRE

    Prachi.G.Bhende; Dr.A.N.Cheeran

    2016-01-01

    X-ray images are gray scale images with almost the same textural characteristic. Conventional texture or color features cannot be used for appropriate categorization in medical x-ray image archives. This paper presents a novel combination of methods like GLCM, LBP and HOG for extracting distinctive invariant features from Xray images belonging to IRMA (Image Retrieval in Medical applications) database that can be used to perform reliable matching between different views of an obje...

  12. An image processing system for digital chest X-ray images.

    Science.gov (United States)

    Cocklin, M; Gourlay, A; Jackson, P; Kaye, G; Miessler, M; Kerr, I; Lams, P

    1984-01-01

    This paper investigates the requirements for image processing of digital chest X-ray images. These images are conventionally recorded on film and are characterised by large size, wide dynamic range and high resolution. X-ray detection systems are now becoming available for capturing these images directly in photoelectronic-digital form. In this report, the hardware and software facilities required for handling these images are described. These facilities include high resolution digital image displays, programmable video look up tables, image stores for image capture and processing and a full range of software tools for image manipulation. Examples are given of the application of digital image processing techniques to this class of image.

  13. High-Resolution X-ray Imaging of the Colliding Wind Shock in WR147

    CERN Document Server

    Pittard, J M; Williams, P M; Pollock, A M T; Skinner, S L; Corcoran, M F; Moffat, A F J

    2002-01-01

    We analyze new high-resolution Chandra X-ray images of the Wolf-Rayet binary system WR147. This system contains a WN8 star with an early-type companion located 0.6'' to its north, and is the only known early-type binary with a separation on the sky large enough for the wind-wind collision between the stars to currently be resolved at X-ray energies. The 5 ksec Chandra HRC-I image provides the first direct evidence for spatially extended X-ray emission in an early-type binary system. The X-ray emission peaks close to the position of the radio bow shock and north of the WN8 star. A deeper X-ray image is needed to accurately determine the degree of spatial extension, to exactly align the X-ray and optical/radio frames, and to determine whether part of the detected X-ray emission arises in the individual stellar winds. Simulated X-ray images of the wind-wind collision have a FWHM consistent with the data, and maximum likelihood fits suggest that a deeper observation may also constrain the inclination and wind mom...

  14. X-ray imaging microscopy at 25 keV with Fresnel zone plate optics

    CERN Document Server

    Awaji, M; Takeuchi, A; Takano, H; Kamijo, N; Tamura, S; Yasumoto, M

    2001-01-01

    X-ray imaging microscopy with a sputtered-sliced Fresnel zone plate (SS-FZP) has been developed at an X-ray energy of 25 keV. Objects were imaged in transmission with the SS-FZP as an objective with a magnification of 10.2 times, and detected with a X-ray image sensor. The performance of the imaging microscope has been tested with a gold mesh and a resolution test pattern at an undulator beamline 47XU of SPring-8. The resolution test patterns up to 0.5 mu m line-and-space structures have been resolved.

  15. 2D-3D image registration in diagnostic and interventional X-Ray imaging

    NARCIS (Netherlands)

    Bom, I.M.J. van der

    2010-01-01

    Clinical procedures that are conventionally guided by 2D x-ray imaging, may benefit from the additional spatial information provided by 3D image data. For instance, guidance of minimally invasive procedures with CT or MRI data provides 3D spatial information and visualization of structures that are

  16. Development of macropore arrays in silicon and related technologies for X-ray imaging applications

    OpenAIRE

    Badel, Xavier

    2003-01-01

    Digital devices have started to replace photographic film inX-ray imaging applications. As compared to photographic films,these devices are more convenient to obtain images and tohandle, treat and store these images. The goal of the presentstudy is to develop macropore arrays and related silicontechnologies in order to fabricate X-ray imaging detectors formedical applications, and in particular for dentistry. Althougha few detectors are already available on the market, theirperformances, such...

  17. Exploration of computerized image processing in underexposed and overexposed X-rays of bones and joints

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhao-chen; ZHANG You-jun; FENG Cheng-qiang; ZHU Yuan-zhong; YAN Shi-yi; LIU Yu-jin

    2004-01-01

    Objective: To study the effective computerized image processing of underexposed and overexposed X-rays of bones and joints. Methods: Ninety-nine conventional X-ray images (82 were overexposed and 17 were underexposed),scanned by an UMAX Astra 4000U Scanner, were converted into digital images on the basis of their analog images. A computerized imaging processing program consisting of five functional modules such as Contrast Stretch, Fast Flourier Transform (FFT), Image Smoothing Modules, Inverse Fast Flourier Transform (IFFT) and Nonlinear Transform performed image contrast stretch and smoothing. Three senior doctors from hospital image sections made their evaluation of all the processed images. Results: Of 82 overexposed films, 71 met the clinical requirements after image processing, and 11 were unable to be applied to clinical diagnosis, accounting for 87% and 13% respectively. Of the other 17 underexposed X-ray images, 11 met the clinical requirements while 6 were not, making a percentage of 64 and 35. Conclusion: Image contrast stretch and smoothing processing are significantly effective on conventional X-ray images which were inappropriately exposed, and can avoid more X-ray radiation caused by handling of radiological photograph again. This method can decrease hospital cost and provide acute and effective X-ray examinations for the treatment and cure for critical patients.

  18. Study on image processing of panoramic X-ray using deviation improvement software.

    Science.gov (United States)

    Kim, Tae-Gon; Lee, Yang-Sun; Kim, Young-Pyo; Park, Yong-Pil; Cheon, Min-Woo

    2014-01-01

    Utilization of panoramic X-ray device is getting wider. Panoramic X-ray has low resolution than general X-ray device and it occurs to distortion by deviation of image synthesis. Due to structural problems, it has been used restrictively to identify of tooth structure, not for whole head. Therefore, it designed and produced panoramic X-ray device which is possible to diagnostic coverage can be extended and had to be adjusted interval control between X-ray generator and image processing for whole of Maxillofacia's diagnosis. Produced panoramic X-ray device is composed basically of short image synthesis. In addition, it was confirmed the results by used the device which was applied deviation of the brightness of the image, filter to improve the location of the deviation and interpolation method. In this study, it was used 13 images including the front. It occurs to brightness deviation, position deviation, and geometric correction when synthesis of image, but it had been solved by deviation improvement software and a change of CCD camera's scan line which is used for image acquisition. Therefore, it confirmed expansion possibility of utilization range to commonly used panoramic X-ray device.

  19. Differential X-ray phase-contrast imaging with a grating interferometer using a laboratory X-ray micro-focus tube

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Kwon-Ha; Ryu, Jong-Hyun; Jung, Chang-Won [Wonkwang University School of Medicine, Iksan (Korea, Republic of); Ryu, Cheol-Woo; Kim, Young-Jo; Kwon, Young-Man [Jeonbuk Technopark, Iksan (Korea, Republic of); Park, Mi-Ran; Cho, Seung-Ryong [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Chon, Kwon-Su [Catholic University of Daegu, Gyeongsan (Korea, Republic of)

    2014-12-15

    X-ray phase-contrast imaging can provide images with much greater soft-tissue contrast than conventional absorption-based images. In this paper, we describe differential X-ray phase-contrast images of insect specimens that were obtained using a grating-based Talbot interferometer and a laboratory X-ray source with a spot size of a few tens of micrometers. We developed the interferometer on the basis of the wavelength, periods, and height of the gratings; the field of view depends on the size of the grating, considering the refractive index of the specimen. The phase-contrast images were acquired using phase-stepping methods. The phase contrast imaging provided a significantly enhanced soft-tissue contrast compared with the attenuation data. The contour of the sample was clearly visible because the refraction from the edges of the object was strong in the differential phase-contrast image. Our results demonstrate that a grating-based Talbot interferometer with a conventional X-ray tube may be attractive as an X-ray imaging system for generating phase images. X-ray phase imaging obviously has sufficient potential and is expected to soon be a great tool for medical diagnostics.

  20. A Spatially Resolved X-ray Image of a Star Like the Sun.

    Science.gov (United States)

    Schmitt, J H; Kürster, M

    1993-10-08

    Observations made with the x-ray satellite ROSAT (Roentgen Satellite) have produced the first spatially resolved x-ray image of a corona around a star like our sun. The star is the secondary in the eclipsing binary system alpha Coronae Borealis (CrB), which consists of one star of spectral type A0V and one of type G5V. The x-ray light curve of alpha CrB shows a total x-ray eclipse during secondary optical minimum, with the G star behind the A star. The totality of the eclipse demonstrates that the A-type component in alpha CrB is x-ray dark and that the x-ray flux arises exclusively from the later-type companion. The x-ray eclipse ingress and egress are highly asymmetric compared with the optical eclipse, indicating a highly asymmetric x-ray intensity distribution on the surface of the G star. From a detailed modeling of the ingress and egress of the x-ray light curve, an eclipse map of the G star was constructed by a method based on an optimization by simulated annealing.

  1. Simultaneous x-ray fluorescence and K-edge CT imaging with photon-counting detectors

    Science.gov (United States)

    Li, Liang; Li, Ruizhe; Zhang, Siyuan; Chen, Zhiqiang

    2016-10-01

    Rapid development of the X-ray phonon-counting detection technology brings tremendous research and application opportunities. In addition to improvements in conventional X-ray imaging performance such as radiation dose utilization and beam hardening correction, photon-counting detectors allows significantly more efficient X-ray fluorescence (XRF) and K-edge imaging, and promises a great potential of X-ray functional, cellular and molecular imaging. XRF is the characteristic emission of secondary X-ray photons from a material excited by initial X-rays. The phenomenon is widely used for chemical and elemental analysis. K-edge imaging identifies a material based on its chemically-specific absorption discontinuity over X-ray photon energy. In this paper, we try to combine XRF and K-edge signals from the contrast agents (e.g., iodine, gadolinium, gold nanoparticles) to simultaneously realize XFCT and K-edge CT imaging for superior image performance. As a prerequisite for this dual-modality imaging, the accurate energy calibration of multi-energy-bin photon-counting detectors is critically important. With the measured XRF data of different materials, we characterize the energy response function of a CZT detector for energy calibration and spectrum reconstruction, which can effectively improve the energy resolution and decrease the inconsistence of the photon counting detectors. Then, a simultaneous K-edge and X-ray fluorescence CT imaging (SKYFI) experimental setup is designed which includes a cone-beam X-ray tube, two separate photon counting detector arrays, a pin-hole collimator and a rotation stage. With a phantom containing gold nanoparticles the two types of XFCT and K-edge CT datasets are collected simultaneously. Then, XFCT and K-edge CT images are synergistically reconstructed in a same framework. Simulation results are presented and quantitative analyzed and compared with the separate XFCT and K-edge CT results.

  2. Radiation hardening of gated x-ray imagers for the National Ignition Facility (invited)a)

    Science.gov (United States)

    Bell, P. M.; Bradley, D. K.; Kilkenny, J. D.; Conder, A.; Cerjan, C.; Hagmann, C.; Hey, D.; Izumi, N.; Moody, J.; Teruya, A.; Celeste, J.; Kimbrough, J.; Khater, H.; Eckart, M. J.; Ayers, J.

    2010-10-01

    The National Ignition Facility will soon be producing x-ray flux and neutron yields higher than any produced in laser driven implosion experiments in the past. Even a non-igniting capsule will require x-ray imaging of near burning plasmas at 1017 neutrons, requiring x-ray recording systems to work in more hostile conditions than we have encountered in past laser facilities. We will present modeling, experimental data and design concepts for x-ray imaging with electronic recording systems for this environment (ARIANE). A novel instrument, active readout in a nuclear environment, is described which uses the time-of-flight difference between the gated x-ray signal and the neutron which induces a background signal to increase the yield at which gated cameras can be used.

  3. Imaging nanoscale magnetic structures with polarized soft x-ray photons

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, P.; Im, M.-Y.

    2010-01-18

    Imaging nanoscale magnetic structures and their fast dynamics is scientifically interesting and technologically of highest relevance. The combination of circularly polarized soft X-ray photons which provide a strong X-ray magnetic circular dichroism effect at characteristic X-ray absorption edges, with a high resolution soft X-ray microscope utilizing Fresnel zone plate optics allows to study in a unique way the stochastical behavior in the magnetization reversal process of thin films and the ultrafast dynamics of magnetic vortices and domain walls in confined ferromagnetic structures. Future sources of fsec short and high intense soft X-ray photon pulses hold the promise of magnetic imaging down to fundamental magnetic length and time scales.

  4. Radiation hardening of gated x-ray imagers for the National Ignition Facility (invited).

    Science.gov (United States)

    Bell, P M; Bradley, D K; Kilkenny, J D; Conder, A; Cerjan, C; Hagmann, C; Hey, D; Izumi, N; Moody, J; Teruya, A; Celeste, J; Kimbrough, J; Khater, H; Eckart, M J; Ayers, J

    2010-10-01

    The National Ignition Facility will soon be producing x-ray flux and neutron yields higher than any produced in laser driven implosion experiments in the past. Even a non-igniting capsule will require x-ray imaging of near burning plasmas at 10(17) neutrons, requiring x-ray recording systems to work in more hostile conditions than we have encountered in past laser facilities. We will present modeling, experimental data and design concepts for x-ray imaging with electronic recording systems for this environment (ARIANE). A novel instrument, active readout in a nuclear environment, is described which uses the time-of-flight difference between the gated x-ray signal and the neutron which induces a background signal to increase the yield at which gated cameras can be used.

  5. Soft X-ray Images of Krypton Gas-Puff Z-Pinches

    Institute of Scientific and Technical Information of China (English)

    邱孟通; 蒯斌; 曾正中; 吕敏; 王奎禄; 邱爱慈; 张美; 罗建辉

    2002-01-01

    A series of experiments has been carried out on Qiang-guang Ⅰ generator to study the dynamics of krypton gas-puff Z-pinches. The generator was operated at a peak current of 1.5 MA with a rise-time of 80 ns. The specific linear mass of gas liner was about 20 μg/cm in these experiments. In the diagnostic system, a four-frame x-ray framing camera and a pinhole camera were employed. A novel feature of this camera is that it can give time-resolved x-ray images with four frames and energy-resolved x-ray images with two different filters and an array of 8 pinholes integrated into one compact assemble. As a typical experimental result, an averaged radial imploding velocity of 157 km/s over 14 ns near the late phase of implosion was measured from the time-resolved x-ray images. From the time-integrated x-ray image an averaged radial convergence of 0.072 times of the original size was measured. An averaged radial expansion velocity was 130 km/s and the maximum radial convergence of 0.04 times of the original size were measured from the time-resolved x-ray images. The dominant axial wavelengths of instabilities in the plasma were between 1 and 2 mm. The change in average photons energy was observed from energy spectrum- and time-resolved x-ray images.

  6. 3D Image Reconstruction from X-Ray Measurements with Overlap

    CERN Document Server

    Klodt, Maria

    2016-01-01

    3D image reconstruction from a set of X-ray projections is an important image reconstruction problem, with applications in medical imaging, industrial inspection and airport security. The innovation of X-ray emitter arrays allows for a novel type of X-ray scanners with multiple simultaneously emitting sources. However, two or more sources emitting at the same time can yield measurements from overlapping rays, imposing a new type of image reconstruction problem based on nonlinear constraints. Using traditional linear reconstruction methods, respective scanner geometries have to be implemented such that no rays overlap, which severely restricts the scanner design. We derive a new type of 3D image reconstruction model with nonlinear constraints, based on measurements with overlapping X-rays. Further, we show that the arising optimization problem is partially convex, and present an algorithm to solve it. Experiments show highly improved image reconstruction results from both simulated and real-world measurements.

  7. A fast method for spine localization in x-ray images.

    Science.gov (United States)

    Huang, Chao-Hui

    2013-01-01

    Detection of spines in medical images are important tasks in medical applications. These tasks are relatively easy for CT/MR images because the bones are easily distinguishable from other tissues. However, they are difficult for x-ray images due to bone and soft tissue overlapping. This paper illustrates a method for detecting the medial axis of spine in x-ray images. Given an initial point on the spine in the x-ray image manually or automatically, the method iteratively searches for good feature points on the spine to locate the medial axis. As a result, the effort of determining the relevant medical information, such as Cobb's angle, can be minimized. The proposed method is fast and efficient. In average it took less than 1 second for localizing the spine on a 3000×1000 gray scale x-ray image.

  8. Bendable X-ray Optics for High Resolution Imaging

    Science.gov (United States)

    Gubarev, M.; Ramsey, B.; Kilaru, K.; Atkins, C.; Broadway, D.

    2014-01-01

    Current state-of the-art for x-ray optics fabrication calls for either the polishing of massive substrates into high-angular-resolution mirrors or the replication of thin, lower-resolution, mirrors from perfectly figured mandrels. Future X-ray Missions will require a change in this optics fabrication paradigm in order to achieve sub-arcsecond resolution in light-weight optics. One possible approach to this is to start with perfectly flat, light-weight surface, bend it into a perfect cone, form the desired mirror figure by material deposition, and insert the resulting mirror into a telescope structure. Such an approach is currently being investigated at MSFC, and a status report will be presented detailing the results of finite element analyses, bending tests and differential deposition experiments.

  9. Image quality simulation and verification of x-ray volume imaging systems

    Science.gov (United States)

    Kroon, Han; Schoumans, Nicole; Snoeren, Ruud

    2006-03-01

    Nowadays, 2D X-ray systems are used more and more for 3-dimensional rotational X-ray imaging (3D-RX) or volume imaging, such as 3D rotational angiography. However, it is not evident that the application of settings for optimal 2D images also guarantee optimal conditions for 3D-RX reconstruction results. In particular the search for a good compromise between patient dose and IQ may lead to different results in case of 3D imaging. For this purpose we developed an additional 3D-RX module for our full-scale image quality & patient dose (IQ&PD) simulation model, with specific calculations of patient dose under rotational conditions, and contrast, sharpness and noise of 3D images. The complete X-ray system from X-ray tube up to and including the display device is modelled in separate blocks for each distinguishable component or process. The model acts as a tool for X-ray system design, image quality optimisation and patient dose reduction. The model supports the decomposition of system level requirements, and takes inherently care of the prerequisite mutual coherence between component requirements. The short calculation times enable comprehensive multi-parameter optimisation studies. The 3D-RX IQ&PD performance is validated by comparing calculation results with actual measurements performed on volume images acquired with a state-of-the-art 3D-RX system. The measurements include RXDI dose index, signal and contrast based on Hounsfield units (H and ΔH), modulation transfer function (MTF), noise variance (σ2) and contrast-to-noise ratio (CNR). Further we developed a new 3D contrast-delta (3D-CΔ) phantom with details of varying size and contrast medium material and concentration. Simulation and measurement results show a significant correlation.

  10. A new X-ray pinhole camera for energy dispersive X-ray fluorescence imaging with high-energy and high-spatial resolution

    Energy Technology Data Exchange (ETDEWEB)

    Romano, F.P., E-mail: romanop@lns.infn.it [IBAM, CNR, Via Biblioteca 4, 95124 Catania (Italy); INFN-LNS, Via S. Sofia 62, 95123 Catania (Italy); Altana, C. [INFN-LNS, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Cosentino, L.; Celona, L.; Gammino, S.; Mascali, D. [INFN-LNS, Via S. Sofia 62, 95123 Catania (Italy); Pappalardo, L. [IBAM, CNR, Via Biblioteca 4, 95124 Catania (Italy); INFN-LNS, Via S. Sofia 62, 95123 Catania (Italy); Rizzo, F. [INFN-LNS, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy)

    2013-08-01

    A new X-ray pinhole camera for the Energy Dispersive X-ray Fluorescence (ED-XRF) imaging of materials with high-energy and high-spatial resolution, was designed and developed. It consists of a back-illuminated and deep depleted CCD detector (composed of 1024 × 1024 pixels with a lateral size of 13 μm) coupled to a 70 μm laser-drilled pinhole-collimator, positioned between the sample under analysis and the CCD. The X-ray pinhole camera works in a coaxial geometry allowing a wide range of magnification values. The characteristic X-ray fluorescence is induced on the samples by irradiation with an external X-ray tube working at a maximum power of 100 W (50 kV and 2 mA operating conditions). The spectroscopic capabilities of the X-ray pinhole camera were accurately investigated. Energy response and energy calibration of the CCD detector were determined by irradiating pure target-materials emitting characteristic X-rays in the energy working-domain of the system (between 3 keV and 30 keV). Measurements were performed by using a multi-frame acquisition in single-photon counting. The characteristic X-ray spectra were obtained by an automated processing of the acquired images. The energy resolution measured at the Fe–Kα line is 157 eV. The use of the X-ray pinhole camera for the 2D resolved elemental analysis was investigated by using reference-patterns of different materials and geometries. The possibility of the elemental mapping of samples up to an area of 3 × 3 cm{sup 2} was demonstrated. Finally, the spatial resolution of the pinhole camera was measured by analyzing the profile function of a sharp-edge. The spatial resolution determined at the magnification values of 3.2 × and 0.8 × (used as testing values) is about 90 μm and 190 μm respectively. - Highlights: • We developed an X-ray pinhole camera for the 2D X-ray fluorescence imaging. • X-ray spectra are obtained by a multi-frame acquisition in single photon mode. • The energy resolution in the X-ray

  11. Development and evaluation of a four-channel digital flash X-ray imaging system

    CERN Document Server

    Wang Yi; Du Hong Lian; Li Yuan Jing; Tian Hui

    2003-01-01

    A four-channel digital flash X-ray imaging system has been developed in our lab. The four flash X-ray heads and four detectors can be used to obtain four radiographic images at four time intervals of an explosion and ballistic trajectory. The cascaded imaging system mainly consists of three parts: (1) a phosphor screen to convert incident X-rays into visible photons; (2) a lens to efficiently collect visible photons emitted by the phosphor screen; and (3) a charge coupled device image sensor to obtain the visible light image. From the analysis of signal and noise propagation, the system is not X-ray quantum-limited, rather the system has secondary quantum sink at the light collecting stage. The construction of the system, theoretical and experimental analysis of performance are presented.

  12. The AAPM/RSNA physics tutorial for residents: X-ray image intensifiers for fluoroscopy.

    Science.gov (United States)

    Wang, J; Blackburn, T J

    2000-01-01

    The x-ray image intensifier converts the transmitted x rays into a brightened, visible light image. Within an image intensifier, the input phosphor converts the x-ray photons to light photons, which are then converted to photoelectrons within the photocathode. The electrons are accelerated and focused by a series of electrodes striking the output phosphor, which converts the accelerated electrons into light photons that may be captured by various imaging devices. Through this process, several thousand light photons are produced for each x-ray photon reaching the input phosphor. Most modern image intensifiers use cesium iodide for the input phosphor because it has a high absorption efficiency and thus decreases patient dose. Image intensifiers come in various sizes, most having more than one input image size or magnification mode. Modern image intensifiers are specified by conversion factors, which is the measure of how efficiently an image intensifier converts x rays to light. Because of design restrictions, image intensifiers are subject to inherent and induced artifacts that contribute to image degradation. Both spatial and contrast resolution gradually decrease during the lifetime of the image intensifier because the brightness gain of an image intensifier decreases with time as the phosphor ages. A well-run quality control program for the image intensifier is needed to detect the inevitable changes in settings before they appear on clinical images.

  13. The Coherent X-ray Imaging instrument at the Linac Coherent Light Source

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Mengning; Williams, Garth J.; Messerschmidt, Marc; Seibert, M. Marvin; Montanez, Paul A.; Hayes, Matt; Milathianaki, Despina; Aquila, Andrew; Hunter, Mark S.; Koglin, Jason E.; Schafer, Donald W.; Guillet, Serge; Busse, Armin; Bergan, Robert; Olson, William; Fox, Kay; Stewart, Nathaniel; Curtis, Robin; Miahnahri, Alireza Alan; Boutet, Sébastien, E-mail: sboutet@slac.stanford.edu [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2015-04-15

    Description of the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source. Recent scientific highlights illustrate the femtosecond crystallography, high power density and extreme matter capabilities of the CXI instrument. The Coherent X-ray Imaging (CXI) instrument specializes in hard X-ray, in-vacuum, high power density experiments in all areas of science. Two main sample chambers, one containing a 100 nm focus and one a 1 µm focus, are available, each with multiple diagnostics, sample injection, pump–probe and detector capabilities. The flexibility of CXI has enabled it to host a diverse range of experiments, from biological to extreme matter.

  14. Imaging of metastatic lymph nodes by X-ray phase-contrast micro-tomography

    DEFF Research Database (Denmark)

    Jensen, Torben Haugaard; Bech, Martin; Binderup, Tina;

    2013-01-01

    whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37-83 years) diagnosed with invasive ductal carcinomas were analyzed by X-ray phase...... was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations...

  15. New opportunities for 3D materials science of polycrystalline materials at the micrometre lengthscale by combined use of X-ray diffraction and X-ray imaging

    DEFF Research Database (Denmark)

    Ludwig, W.; King, A.; Reischig, P.

    2009-01-01

    Non-destructive, three-dimensional (3D) characterization of the grain structure in mono-phase polycrystalline materials is an open challenge in material science. Recent advances in synchrotron based X-ray imaging and diffraction techniques offer interesting possibilities for mapping 3D grain shapes...... and crystallographic orientations for certain categories of polycrystalline materials. Direct visualisation of the three-dimensional grain boundary network or of two-phase (duplex) grain structures by means of absorption and/or phase contrast techniques may be possible, but is restricted to specific material systems....... A recent extension of this methodology, termed X-ray diffraction contrast tomography (DCT), combines the principles of X-ray diffraction imaging, three-dimensional X-ray diffraction microscopy (3DXRD) and image reconstruction from projections. DCT provides simultaneous access to 3D grain shape...

  16. An X-ray Imaging Survey of Quasar Jets -- Testing the Inverse Compton Model

    CERN Document Server

    Marshall, H L; Schwartz, D A; Murphy, D W; Lovell, J E J; Worrall, D M; Birkinshaw, M; Perlman, E S; Godfrey, L; Jauncey, D L

    2011-01-01

    We present results from continued Chandra X-ray imaging and spectroscopy of a flux-limited sample of flat spectrum radio-emitting quasars with jet-like extended structure. X-rays are detected from 24 of the 39 jets observed so far. We compute the distribution of alpha_rx, the spectral index between the X-ray and radio bands, showing that it is broad, extending at least from 0.8 to 1.2. While there is a general trend that the radio brightest jets are detected most often, it is clear that predicting the X-ray flux from the radio knot flux densities is risky so a shallow X-ray survey is the most effective means for finding jets that are X-ray bright. We test the model in which the X-rays result from inverse Compton (IC) scattering of cosmic microwave background (CMB) photons by relativistic electrons in the jet moving with high bulk Lorentz factor nearly along the line of sight. Depending on how the jet magnetic fields vary with z, the observed X-ray to radio flux ratios do not follow the redshift dependence exp...

  17. X-Ray Diffraction and Imaging Study of Imperfections of Crystallized Lysozyme with Coherent X-Rays

    Science.gov (United States)

    Hu, Zheng-Wei; Chu, Y. S.; Lai, B.; Cai, Z.; Thomas, B. R.; Chernov, A. A.

    2003-01-01

    Phase-sensitive x-ray diffraction imaging and high angular-resolution diffraction combined with phase contrast radiographic imaging are employed to characterize defects and perfection of a uniformly grown tetragonal lysozyme crystal in symmetric Laue case. The fill width at half-maximum (FWHM) of a 4 4 0 rocking curve measured from the original crystal is approximately 16.7 arcseconds, and defects, which include point defects, line defects, and microscopic domains, have been clearly observed in the diffraction images of the crystal. The observed line defects carry distinct dislocation features running approximately along the growth front, and they have been found to originate mostly at a central growth area and occasionally at outer growth regions. Individual point defects trapped at a crystal nucleus are resolved in the images of high sensitivity to defects. Slow dehydration has led to the broadening of the 4 4 0 rocking curve by a factor of approximately 2.4. A significant change of the defect structure and configuration with drying has been revealed, which suggests the dehydration induced migration and evolution of dislocations and lattice rearrangements to reduce overall strain energy. The sufficient details of the observed defects shed light upon perfection, nucleation and growth, and properties of protein crystals.

  18. Imaging Molecular Structure and Dynamics utilizing X-ray Free-Electron-Laser Sources

    OpenAIRE

    Küpper, Jochen

    2015-01-01

    Imaging controlled molecules with ultrashort x- ray pulses from free-electron lasers enables the recording of “molecular movies”, i.e., snapshots of molecules at work, with spatial (picometer) and temporal (femtosecond) atomic resolution.

  19. High Spectral Resolution, High Cadence, Imaging X-ray Microcalorimeters for Solar Physics - Phase 2 Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Microcalorimeter x-ray instruments are non-dispersive, high spectral resolution, broad-band, high cadence imaging spectrometers. We have been developing these...

  20. Wide Field-of-View (FOV) Soft X-Ray Imager Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Wide Field-of-View (FOV) Soft X-Ray Imager proposes to be a state-of-art instrument with applications for numerous heliospheric and planetary...

  1. eHXI: a permanently installed, hard x-ray imager for the National Ignition Facility

    Science.gov (United States)

    Döppner, T.; Bachmann, B.; Albert, F.; Bell, P.; Burns, S.; Celeste, J.; Chow, R.; Divol, L.; Dewald, E. L.; Hohenberger, M.; Huntington, C. M.; Izumi, N.; LaCaille, G.; Landen, O. L.; Palmer, N.; Park, H.-S.; Thomas, C. A.

    2016-06-01

    We have designed and built a multi-pinhole imaging system for high energy x-rays (>= 50 keV) that is permanently installed in the equatorial plane outside of the target chamber at the National Ignition Facility (NIF). It records absolutely-calibrated, time-integrated x-ray images with the same line-of-sight as the multi-channel, spatially integrating hard x-ray detector FFLEX [McDonald et al., Rev. Sci. Instrum. 75 (2004) 3753], having a side view of indirect-drive inertial confinement fusion (ICF) implosion targets. The equatorial hard x-ray imager (eHXI) has recorded images on the majority of ICF implosion experiments since May 2011. eHXI provides valuable information on hot electron distribution in hohlraum experiments, target alignment, potential hohlraum drive asymmetries and serves as a long term reference for the FFLEX diagnostics.

  2. Spherical-Wave Far-Field Interferometer for Hard X-Ray Phase Contrast Imaging

    CERN Document Server

    Miao, Houxun; Harmon, Katherine J; Bennett, Eric E; Chedid, Nicholas; Panna, Alireza; Bhandarkar, Priya; Wen, Han

    2014-01-01

    Low dose, high contrast x-ray imaging is of general interest in medical diagnostic applications. X-ray Mach-Zehnder interferometers using collimated synchrotron beams demonstrate the highest levels of phase contrast under a given exposure dose. However, common x-ray sources emit divergent cone beams. Here, we developed a spherical-wave inline Mach-Zehnder interferometer for phase contrast imaging over an extended area with a broadband and divergent source. The first tabletop system was tested in imaging experiments of a mammographic accreditation phantom and various biological specimens. The noise level of the phase contrast images at a clinical radiation dose corresponded to a 6 nano radian bending of the x-ray wavefront. Un-resolved structures with conventional radiography and near-field interferometer techniques became visible at a fraction of the radiation dose.

  3. Resolution enhancement in coherent x-ray diffraction imaging by overcoming instrumental noise.

    Science.gov (United States)

    Kim, Chan; Kim, Yoonhee; Song, Changyong; Kim, Sang Soo; Kim, Sunam; Kang, Hyon Chol; Hwu, Yeukuang; Tsuei, Ku-Ding; Liang, Keng San; Noh, Do Young

    2014-11-17

    We report that reference objects, strong scatterers neighboring weak phase objects, enhance the phase retrieval and spatial resolution in coherent x-ray diffraction imaging (CDI). A CDI experiment with Au nano-particles exhibited that the reference objects amplified the signal-to-noise ratio in the diffraction intensity at large diffraction angles, which significantly enhanced the image resolution. The interference between the diffracted x-ray from reference objects and a specimen also improved the retrieval of the phase of the diffraction signal. The enhancement was applied to image NiO nano-particles and a mitochondrion and confirmed in a simulation with a bacteria phantom. We expect that the proposed method will be of great help in imaging weakly scattering soft matters using coherent x-ray sources including x-ray free electron lasers.

  4. Image-based spectral distortion correction for photon-counting x-ray detectors

    OpenAIRE

    Ding, Huanjun; Molloi, Sabee

    2012-01-01

    Purpose: To investigate the feasibility of using an image-based method to correct for distortions induced by various artifacts in the x-ray spectrum recorded with photon-counting detectors for their application in breast computed tomography (CT).

  5. Material depth reconstruction method of multi-energy X-ray images using neural network.

    Science.gov (United States)

    Lee, Woo-Jin; Kim, Dae-Seung; Kang, Sung-Won; Yi, Won-Jin

    2012-01-01

    With the advent of technology, multi-energy X-ray imaging is promising technique that can reduce the patient's dose and provide functional imaging. Two-dimensional photon-counting detector to provide multi-energy imaging is under development. In this work, we present a material decomposition method using multi-energy images. To acquire multi-energy images, Monte Carlo simulation was performed. The X-ray spectrum was modeled and ripple effect was considered. Using the dissimilar characteristics in energy-dependent X-ray attenuation of each material, multiple energy X-ray images were decomposed into material depth images. Feedforward neural network was used to fit multi-energy images to material depth images. In order to use the neural network, step wedge phantom images were used for training neuron. Finally, neural network decomposed multi-energy X-ray images into material depth image. To demonstrate the concept of this method, we applied it to simulated images of a 3D head phantom. The results show that neural network method performed effectively material depth reconstruction.

  6. Ptychographic coherent x-ray diffractive imaging in the water window

    OpenAIRE

    Giewekemeyer, K.; Beckers, M.; Gorniak, T.; Grunze, M.; Salditt, T.; Rosenhahn, A.

    2011-01-01

    Coherent x-ray diffractive microscopy enables full reconstruction of the complex transmission function of an isolated object to diffraction-limited resolution without relying on any optical elements between the sample and detector. In combination with ptychography, also specimens of unlimited lateral extension can be imaged. Here we report on an application of ptychographic coherent diffractive imaging (PCDI) in the soft x-ray regime, more precisely in the so-called water wi...

  7. X-ray phase imaging with a laboratory source using selective reflection from a mirror.

    Science.gov (United States)

    Pelliccia, Daniele; Paganin, David M

    2013-04-22

    A novel approach for hard x-ray phase contrast imaging with a laboratory source is reported. The technique is based on total external reflection from the edge of a mirror, aligned to intercept only half of the incident beam. The mirror edge thus produces two beams. The refraction x-rays undergo when interacting with a sample placed before the mirror, causes relative intensity variations between direct and reflected beams. Quantitative phase contrast and pure absorption imaging are demonstrated using this method.

  8. Elemental mapping in a contemporary miniature by full-field X-ray fluorescence imaging with gaseous detector vs. scanning X-ray fluorescence imaging with polycapillary optics

    Science.gov (United States)

    Silva, A. L. M.; Cirino, S.; Carvalho, M. L.; Manso, M.; Pessanha, S.; Azevedo, C. D. R.; Carramate, L. F. N. D.; Santos, J. P.; Guerra, M.; Veloso, J. F. C. A.

    2017-03-01

    Energy dispersive X-ray imaging can be used in several research fields and industrial applications. Elemental mapping through energy dispersive X-ray imaging technique has become a promising method to obtain positional distribution of specific elements in a non-destructive way. To obtain the elemental distribution of a sample it is necessary to use instruments capable of providing a precise positioning together with a good energy resolution. Polycapillary beams together with silicon drift chamber detectors are used in several commercial systems and are considered state-of-the-art spectrometers, however they are usually very costly. A new concept of large energy dispersive X-ray imaging systems based on gaseous radiation detectors emerged in the last years enabling a promising 2D elemental detection at a very reduced price. The main goal of this work is to analyze a contemporary Indian miniature with both X-ray fluorescence imaging systems, the one based on a gaseous detector 2D-THCOBRA and the state-of-the-art spectrometer M4 Tornado, from Bruker. The performance of both systems is compared and evaluated in the context of the sample's analysis.

  9. MMX-I: data-processing software for multimodal X-ray imaging and tomography

    Energy Technology Data Exchange (ETDEWEB)

    Bergamaschi, Antoine, E-mail: antoine.bergamaschi@synchrotron-soleil.fr; Medjoubi, Kadda [Synchrotron SOLEIL, BP 48, Saint-Aubin, 91192 Gif sur Yvette (France); Messaoudi, Cédric; Marco, Sergio [Université Paris-Saclay, CNRS, Université Paris-Saclay, F-91405 Orsay (France); Institut Curie, INSERM, PSL Reseach University, F-91405 Orsay (France); Somogyi, Andrea [Synchrotron SOLEIL, BP 48, Saint-Aubin, 91192 Gif sur Yvette (France)

    2016-04-12

    The MMX-I open-source software has been developed for processing and reconstruction of large multimodal X-ray imaging and tomography datasets. The recent version of MMX-I is optimized for scanning X-ray fluorescence, phase-, absorption- and dark-field contrast techniques. This, together with its implementation in Java, makes MMX-I a versatile and friendly user tool for X-ray imaging. A new multi-platform freeware has been developed for the processing and reconstruction of scanning multi-technique X-ray imaging and tomography datasets. The software platform aims to treat different scanning imaging techniques: X-ray fluorescence, phase, absorption and dark field and any of their combinations, thus providing an easy-to-use data processing tool for the X-ray imaging user community. A dedicated data input stream copes with the input and management of large datasets (several hundred GB) collected during a typical multi-technique fast scan at the Nanoscopium beamline and even on a standard PC. To the authors’ knowledge, this is the first software tool that aims at treating all of the modalities of scanning multi-technique imaging and tomography experiments.

  10. An active contour method for bone cement reconstruction from C-arm x-ray images.

    Science.gov (United States)

    Lucas, Blake C; Otake, Yoshito; Armand, Mehran; Taylor, Russell H

    2012-04-01

    A novel algorithm is presented to segment and reconstruct injected bone cement from a sparse set of X-ray images acquired at arbitrary poses. The sparse X-ray multi-view active contour (SxMAC-pronounced "smack") can 1) reconstruct objects for which the background partially occludes the object in X-ray images, 2) use X-ray images acquired on a noncircular trajectory, and 3) incorporate prior computed tomography (CT) information. The algorithm's inputs are preprocessed X-ray images, their associated pose information, and prior CT, if available. The algorithm initiates automated reconstruction using visual hull computation from a sparse number of X-ray images. It then improves the accuracy of the reconstruction by optimizing a geodesic active contour. Experiments with mathematical phantoms demonstrate improvements over a conventional silhouette based approach, and a cadaver experiment demonstrates SxMAC's ability to reconstruct high contrast bone cement that has been injected into a femur and achieve sub-millimeter accuracy with four images.

  11. Projection x-ray imaging with photon energy weighting: experimental evaluation with a prototype detector.

    Science.gov (United States)

    Shikhaliev, Polad M

    2009-08-21

    The signal-to-noise ratio (SNR) in x-ray imaging can be increased using a photon counting detector which could allow for rejecting electronics noise and for weighting x-ray photons according to their energies. This approach, however, was not feasible for a long time because photon counting x-ray detectors with very high count rates, good energy resolution and a large number of small pixels were required. These problems have been addressed with the advent of new detector materials, fast readout electronics and powerful computers. In this work, we report on the experimental evaluation of projection x-ray imaging with a photon counting cadmium-zinc-telluride (CZT) detector with energy resolving capabilities. The detector included two rows of pixels with 128 pixels per row with 0.9 x 0.9 mm(2) pixel size, and a 2 Mcount pixel(-1) s(-1) count rate. The x-ray tube operated at 120 kVp tube voltage with 2 mm Al-equivalent inherent filtration. The x-ray spectrum was split into five regions, and five independent x-ray images were acquired at a time. These five quasi-monochromatic x-ray images were used for x-ray energy weighting and material decomposition. A tissue-equivalent phantom was used including contrast elements simulating adipose, calcifications, iodine and air. X-ray energy weighting improved the SNR of calcifications and iodine by a factor of 1.32 and 1.36, respectively, as compared to charge integrating. Material decomposition was performed by dual energy subtraction. The low- and high-energy images were generated in the energy ranges of 25-60 keV and 60-120 keV, respectively, by combining five monochromatic image data into two. X-ray energy weighting was applied to low- and high-energy images prior to subtraction, and this improved the SNR of calcifications and iodine in dual energy subtracted images by a factor of 1.34 and 1.25, respectively, as compared to charge integrating. The detector energy resolution, spatial resolution, linearity, count rate, noise and

  12. Note: Dynamic strain field mapping with synchrotron X-ray digital image correlation

    Energy Technology Data Exchange (ETDEWEB)

    Lu, L. [CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui 230027 (China); The Peac Institute of Multiscale Sciences, Chengdu, Sichuan 610207 (China); Fan, D.; Luo, S. N., E-mail: sluo@pims.ac.cn [The Peac Institute of Multiscale Sciences, Chengdu, Sichuan 610207 (China); Bie, B. X. [The Peac Institute of Multiscale Sciences, Chengdu, Sichuan 610207 (China); School of Science, Wuhan University of Technology, Wuhan, Hubei 430070 (China); Ran, X. X.; Qi, M. L., E-mail: qiml@whut.edu.cn [School of Science, Wuhan University of Technology, Wuhan, Hubei 430070 (China); Parab, N.; Sun, J. Z.; Liao, H. J.; Hudspeth, M. C.; Claus, B. [School of Aeronautics and Astronautics, Purdue University, West Lafayette, Indiana 47907 (United States); Fezzaa, K.; Sun, T. [Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Chen, W. [School of Aeronautics and Astronautics, Purdue University, West Lafayette, Indiana 47907 (United States); School of Material Science Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Gong, X. L., E-mail: gongxl@ustc.edu.cn [CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui 230027 (China)

    2014-07-15

    We present a dynamic strain field mapping method based on synchrotron X-ray digital image correlation (XDIC). Synchrotron X-ray sources are advantageous for imaging with exceptional spatial and temporal resolutions, and X-ray speckles can be produced either from surface roughness or internal inhomogeneities. Combining speckled X-ray imaging with DIC allows one to map strain fields with high resolutions. Based on experiments on void growth in Al and deformation of a granular material during Kolsky bar/gas gun loading at the Advanced Photon Source beamline 32ID, we demonstrate the feasibility of dynamic XDIC. XDIC is particularly useful for dynamic, in-volume, measurements on opaque materials under high strain-rate, large, deformation.

  13. X-ray Absorption Imaging of High-Intensity Discharge Lamps Using Monochromatic Synchrotron Radiation

    Science.gov (United States)

    Curry, John J.; Sansonetti, Craig J.; Hechtfischer, Ulrich; Adler, Helmar G.

    2002-10-01

    We will report results from the imaging of Hg vapor in high-intensity discharge lamps using synchrotron radiation and digital detectors. These measurements extend previous work on x-ray absorption imaging in arc lamps using an x-ray tube and a passive phosphor image plate detector^i. The large x-ray flux obtained from the Advanced Photon Source (Argonne National Laboratory) combined with the electronic gating capabilities of an intensified charge-coupled device detector have allowed us to obtain time-resolved Hg distributions with high spatial resolution. Monochromatic synchrotron radiation improves the accuracy over what can be obtained with quasi-continuum radiation from an x-ray tube source. ^iJ. J. Curry, M. Sakai, and J. E. Lawler, Journal of Applied Physics 84, 3066 (1998).

  14. Spatial harmonic imaging of X-ray scattering--initial results.

    Science.gov (United States)

    Wen, Han; Bennett, Eric E; Hegedus, Monica M; Carroll, Stefanie C

    2008-08-01

    Coherent X-ray scattering is related to the electron density distribution by a Fourier transform, and therefore a window into the microscopic structures of biological samples. Current techniques of scattering rely on small-angle measurements from highly collimated X-ray beams produced from synchrotron light sources. Imaging of the distribution of scattering provides a new contrast mechanism which is different from absorption radiography, but is a lengthy process of raster or line scans of the beam over the object. Here, we describe an imaging technique in the spatial frequency domain capable of acquiring both the scattering and absorption distributions in a single exposure. We present first results obtained with conventional X-ray equipment. This method interposes a grid between the X-ray source and the imaged object, so that the grid-modulated image contains a primary image and a grid harmonic image. The ratio between the harmonic and primary images is shown to be a pure scattering image. It is the auto-correlation of the electron density distribution at a specific distance. We tested a number of samples at 60-200 nm autocorrelation distance, and found the scattering images to be distinct from the absorption images and reveal new features. This technique is simple to implement, and should help broaden the imaging applications of X-ray scattering.

  15. An Imaging and Spectral Study of Ten X-Ray Filaments around the Galactic Center

    CERN Document Server

    Lu, F J; Lou, Y -Q

    2007-01-01

    We report the detection of 10 new X-ray filaments using the data from the {\\sl Chandra} X-ray satellite for the inner $6^{\\prime}$ ($\\sim 15$ parsec) around the Galactic center (GC). All these X-ray filaments are characterized by non-thermal energy spectra, and most of them have point-like features at their heads that point inward. Fitted with the simple absorbed power-law model, the measured X-ray flux from an individual filament in the 2-10 keV band is $\\sim 2.8\\times10^{-14}$ to $10^{-13}$ ergs cm$^{-2}$ s$^{-1}$ and the absorption-corrected X-ray luminosity is $\\sim 10^{32}-10^{33}$ ergs s$^{-1}$ at a presumed distance of 8 kpc to the GC. We speculate the origin(s) of these filaments by morphologies and by comparing their X-ray images with the corresponding radio and infrared images. On the basis of combined information available, we suspect that these X-ray filaments might be pulsar wind nebulae (PWNe) associated with pulsars of age $10^3 \\sim 3\\times 10^5$ yr. The fact that most of the filament tails po...

  16. Applications of the Generalized X-ray Diffraction Enhanced Imaging in the Medical Imaging

    Science.gov (United States)

    Maksimenko, Anton; Hashimoto, Eiko; Ando, Masami; Sugiyama, Hiroshi

    2007-01-01

    The X-ray Diffraction Enhanced Imaging (DEI) is the analyzer-based X-ray imaging technique which allows extraction of the "pure refraction" and "apparent absorption" contrasts from two images taken on the opposite sides of the rocking curve of the analyzing crystal. The refraction contrast obtained by this method shows many advantages over conventional absorption contrast. It was successfully applied in medicine, technique and other fields of science. However, information provided by the method is rather qualitative than quantitative. This happens because either side of the rocking curve of the analyzer is approximated as a straight line what limits the ranges of applicability and introduces additional error. One can easily overcome this problem considering the rocking curve as is instead of it's Taylor's expansion. This report is dedicated to the application of this idea in medical imaging and especially computed tomography based on the refraction contrast. The results obtained via both methods are presented and compared.

  17. Automatic Defect Detection in X-Ray Images Using Image Data Fusion

    Institute of Scientific and Technical Information of China (English)

    TIAN Yuan; DU Dong; CAI Guorui; WANG Li; ZHANG Hua

    2006-01-01

    Automatic defect detection in X-ray images is currently a focus of much research at home and abroad. The technology requires computerized image processing, image analysis, and pattern recognition. This paper describes an image processing method for automatic defect detection using image data fusion which synthesizes several methods including edge extraction, wave profile analyses, segmentation with dynamic threshold, and weld district extraction. Test results show that defects that induce an abrupt change over a predefined extent of the image intensity can be segmented regardless of the number, location, shape, or size. Thus, the method is more robust and practical than the current methods using only one method.

  18. Radiation exposure and image quality in x-Ray diagnostic radiology physical principles and clinical applications

    CERN Document Server

    Aichinger, Horst; Joite-Barfuß, Sigrid; Säbel, Manfred

    2012-01-01

    The largest contribution to radiation exposure to the population as a whole arises from diagnostic X-rays. Protecting the patient from radiation is a major aim of modern health policy, and an understanding of the relationship between radiation dose and image quality is of pivotal importance in optimising medical diagnostic radiology. In this volume the data provided for exploring these concerns are partly based on X-ray spectra, measured on diagnostic X-ray tube assemblies, and are supplemented by the results of measurements on phantoms and simulation calculations.

  19. Approach of Image Stream Apply to X-ray Scan Imaging Equipment

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Wei

    2013-01-01

    A thin beam of X-rays is scanned over the surface of the mass being examined as the material moved on the belt.Jumped spots arranged make up a scan line,and lines constituting the surface.The scan lines of data obtained sequentially,which is re-arranged form an image pixel data in the memory,constituting a digital image displayed on a display.

  20. Manufacturing and testing of X-ray imaging components with high precision

    Institute of Scientific and Technical Information of China (English)

    HU Jia-sheng; WU Xü

    2005-01-01

    In the latest 20 years, X-ray imaging technology has developed rapidly in order to meet the needs of X-ray photo-etching,spatial exploration technology, high-energy physics, procedure diagnosis of ICF,etc. Since refractive indices of materials in the X-ray region are lower than 1, and X-ray is strongly absorbed by materials, the characteristics of X-ray increase greatly difficulty to obtain X-ray image. Conventional imaging methods are hardly suitable to X-ray range. In general, grazing reflective imaging and coding aperture imaging methods have been adopted more and more.We have designed a non-coaxial grazing reflective X-ray microscope which is composed of four spherical mirrors, in order to satisfy the requirement of the diagnosis of inertial confinement fusion (ICF). The four mirrors have the same radius of curvature. The radius of each mirror is 29 000 mm and the aperture is 30 mm×15 mm. Allowable tolerance of the radius is ≤0.2% and one of surface roughness (rms) is ≤0.6 nm. Evidently it is very difficult to fabricate and test such mirrors. In order to obtain eligible mirrors, we choose 18 mirror roughcasts and array them on a round disk according to format. The combined manufacturing method can ensure high accordant quality. The fabricated mirrors are tested by both templet and double round aperture methods. Radius errors of the mirrors is about 53 mm. The surface roughness (rms) of the mirrors is inspected by the relative interferometric equipment (WYKO) and atomic force microscope. Before and after coating the measured surface roughness is averagely 0.52 nm and 0.4 nm, respectively.

  1. Imaging performance and tests of soft x-ray telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Spiller, E.; McCorkle, R.; Wilczynski, J. (International Business Machines Corp., Yorktown Heights, NY (USA). Thomas J. Watson Research Center); Golub, L.; Nystrom, G. (Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (USA)); Takacz, P.Z. (Brookhaven National Lab., Upton, NY (USA)); Welch, C. (Lockheed Missile and Space Co., Las Cruces, NM (USA))

    1990-08-01

    Photos obtained during 5 min. of observation time from the flight of our 10 in. normal incidence soft x-ray ({lambda} = 63.5{Angstrom}) telescope on September 11, 1989 are analyzed and the data are compared to the results expected from tests of the mirror surfaces. These tests cover a range of spatial periods from 25 cm to 1{Angstrom}. The photos demonstrate a reduction in the scattering of the multilayer mirror compared to a single surface for scattering angles above 1 arcmin, corresponding to surface irregularities with spatial periods below 10 {mu}m. Our results are used to predict the possible performance of future flights. Sounding rocket observations might be able to reach a resolution around 0.1 arcsec. Higher resolutions will require flights of longer durations and improvements in mirror testing for the largest spatial periods. 21 refs., 7 figs., 1 tab.

  2. Assessment of image quality in x-ray radiography imaging using a small plasma focus device

    Science.gov (United States)

    Kanani, A.; Shirani, B.; Jabbari, I.; Mokhtari, J.

    2014-08-01

    This paper offers a comprehensive investigation of image quality parameters for a small plasma focus as a pulsed hard x-ray source for radiography applications. A set of images were captured from some metal objects and electronic circuits using a low energy plasma focus at different voltages of capacitor bank and different pressures of argon gas. The x-ray source focal spot of this device was obtained to be about 0.6 mm using the penumbra imaging method. The image quality was studied by several parameters such as image contrast, line spread function (LSF) and modulation transfer function (MTF). Results showed that the contrast changes by variations in gas pressure. The best contrast was obtained at a pressure of 0.5 mbar and 3.75 kJ stored energy. The results of x-ray dose from the device showed that about 0.6 mGy is sufficient to obtain acceptable images on the film. The measurements of LSF and MTF parameters were carried out by means of a thin stainless steel wire 0.8 mm in diameter and the cut-off frequency was obtained to be about 1.5 cycles/mm.

  3. Resolving hot spot microstructure using x-ray penumbral imaging (invited)

    Science.gov (United States)

    Bachmann, B.; Hilsabeck, T.; Field, J.; Masters, N.; Reed, C.; Pardini, T.; Rygg, J. R.; Alexander, N.; Benedetti, L. R.; Döppner, T.; Forsman, A.; Izumi, N.; LePape, S.; Ma, T.; MacPhee, A. G.; Nagel, S.; Patel, P.; Spears, B.; Landen, O. L.

    2016-11-01

    We have developed and fielded x-ray penumbral imaging on the National Ignition Facility in order to enable sub-10 μm resolution imaging of stagnated plasma cores (hot spots) of spherically shock compressed spheres and shell implosion targets. By utilizing circular tungsten and tantalum apertures with diameters ranging from 20 μm to 2 mm, in combination with image plate and gated x-ray detectors as well as imaging magnifications ranging from 4 to 64, we have demonstrated high-resolution imaging of hot spot plasmas at x-ray energies above 5 keV. Here we give an overview of the experimental design criteria involved and demonstrate the most relevant influences on the reconstruction of x-ray penumbral images, as well as mitigation strategies of image degrading effects like over-exposed pixels, artifacts, and photon limited source emission. We describe experimental results showing the advantages of x-ray penumbral imaging over conventional Fraunhofer and photon limited pinhole imaging and showcase how internal hot spot microstructures can be resolved.

  4. Phase Sensitive X-Ray Diffraction Imaging Study of Protein Crystals

    Science.gov (United States)

    Hu, Z. W.

    2003-01-01

    The study of defects and growth of protein crystals is of importance in providing a fundamental understanding of this important category of systems and the rationale for crystallization of better ordered crystals for structural determination and drug design. Yet, as a result of the extremely weak scattering power of x-rays in protein and other biological macromolecular crystals, the extinction lengths for those crystals are extremely large and, roughly speaking, of the order of millimeters on average compared to the scale of micrometers for most small molecular crystals. This has significant implication for x-ray diffraction and imaging study of protein crystals, and presents an interesting challenge to currently available x-ray analytical techniques. We proposed that coherence-based phase sensitive x-ray diffraction imaging could provide a way to augment defect contrast in x-ray diffraction images of weakly diffracting biological macromolecular crystals. I shall examine the principles and ideas behind this approach and compare it to other available x-ray topography and diffraction methods. I shall then present some recent experimental results in two model protein systems-cubic apofemtin and tetragonal lysozyme crystals to demonstrate the capability of the coherence-based imaging method in mapping point defects, dislocations, and the degree of perfection of biological macromolecular crystals with extreme sensitivity. While further work is under way, it is intended to show that the observed new features have yielded important information on protein crystal perfection and nucleation and growth mechanism otherwise unobtainable.

  5. X-ray imaging and spectroscopy using low cost COTS CMOS sensors

    Energy Technology Data Exchange (ETDEWEB)

    Lane, David W., E-mail: d.w.lane@cranfield.ac.uk [Department of Engineering and Applied Science, Cranfield University, Shrivenham, Swindon SN6 8LA (United Kingdom)

    2012-08-01

    Whilst commercial X-ray sensor arrays are capable of both imaging and spectroscopy they are currently expensive and this can limit their widespread use. This study examines the use of very low cost CMOS sensors for X-ray imaging and spectroscopy based on the commercial off the shelf (COTS) technology used in cellular telephones, PC multimedia and children's toys. Some examples of imaging using a 'webcam' and a modified OmniVision OV7411 sensor are presented, as well as a simple energy dispersive X-ray detector based on an OmniVision OV7221 sensor. In each case X-ray sensitivity was enabled by replacing the sensor's front glass window with a 5 {mu}m thick aluminium foil, with X-rays detected as an increase in a pixel's dark current due to the generation of additional electron-hole pairs within its active region. The exposure control and data processing requirements for imaging and spectroscopy are discussed. The modified OV7221 sensor was found to have a linear X-ray energy calibration and a resolution of approximately 510 eV.

  6. X-ray dark-field imaging and its application. Laue case analyzer

    CERN Document Server

    Ando, M

    2003-01-01

    A system on X-ray dark-field imaging under development and its application is reported. That comprises an asymmetric monochromator and a Laue case analyzer that has a specified thickness for a given X-ray photon energy or wavelength and a sample locating inbetween these. This system uses Si 4,4,0 diffraction for both X-ray optics element in a parallel arrangement. In order to achieve the dark-field imaging condition the Si Laue analyzer should be 1.075 mm in thickness for the X-ray energy of 35 keV. Since this system is very simple one can expect a variety of applications including material science, biology, palaeontology and clinical medicine where a large view area with size of 100 mm x 100 mm is needed. (author)

  7. Study of Scintillator thickness optimization of lens-coupled X-ray imaging detectors

    Science.gov (United States)

    Xie, H.; Du, G.; Deng, B.; Chen, R.; Xiao, T.

    2016-03-01

    Lens-coupled X-ray in-direct imaging detectors are very popular for high-resolution X-ray imaging at the third generation synchrotron radiation facilities. This imaging system consists of a scintilator producing a visible-light image of X-ray beam, a microscope objective, a mirror reflecting at 90° and a CCD camera. When the thickness of the scintillator is matched with the numerical aperture (NA) of the microscope objective, the image quality of experimental results will be improved obviously. This paper used an imaging system at BL13W beamline of Shanghai Synchrotron Radiation Facility (SSRF) to study the matching relation between the scintillator thickness and the NA of the microscope objective with a real sample. By use of the matching relation between the scintillator thickness and the NA of the microscope objective, the optimal imaging results have been obtained.

  8. Expanded image database of pistachio x-ray images and classification by conventional methods

    Science.gov (United States)

    Keagy, Pamela M.; Schatzki, Thomas F.; Le, Lan Chau; Casasent, David P.; Weber, David

    1996-12-01

    In order to develop sorting methods for insect damaged pistachio nuts, a large data set of pistachio x-ray images (6,759 nuts) was created. Both film and linescan sensor images were acquired, nuts dissected and internal conditions coded using the U.S. Grade standards and definitions for pistachios. A subset of 1199 good and 686 insect damaged nuts was used to calculate and test discriminant functions. Statistical parameters of image histograms were evaluated for inclusion by forward stepwise discrimination. Using three variables in the discriminant function, 89% of test set nuts were correctly identified. Comparable data for 6 human subjects ranged from 67 to 92%. If the loss of good nuts is held to 1% by requiring a high probability to discard a nut as insect damaged, approximately half of the insect damage present in clean pistachio nuts may be detected and removed by x-ray inspection.

  9. X-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects using 110 kVp x-rays

    Energy Technology Data Exchange (ETDEWEB)

    Cheong, Seong-Kyun; Jones, Bernard L; K Siddiqi, Arsalan; Liu, Fang; Manohar, Nivedh; Cho, Sang Hyun [Nuclear and Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (United States)], E-mail: scho@gatech.edu

    2010-02-07

    A conventional x-ray fluorescence computed tomography (XFCT) technique requires monochromatic synchrotron x-rays to simultaneously determine the spatial distribution and concentration of various elements such as metals in a sample. However, the synchrotron-based XFCT technique appears to be unsuitable for in vivo imaging under a typical laboratory setting. In this study we demonstrated, for the first time to our knowledge, the possibility of performing XFCT imaging of a small animal-sized object containing gold nanoparticles (GNPs) at relatively low concentrations using polychromatic diagnostic energy range x-rays. Specifically, we created a phantom made of polymethyl methacrylate plastic containing two cylindrical columns filled with saline solution at 1 and 2 wt% GNPs, respectively, mimicking tumors/organs within a small animal. XFCT scanning of the phantom was then performed using microfocus 110 kVp x-ray beam and cadmium telluride (CdTe) x-ray detector under a pencil beam geometry after proper filtering of the x-ray beam and collimation of the detector. The reconstructed images clearly identified the locations of the two GNP-filled columns with different contrast levels directly proportional to gold concentration levels. On the other hand, the current pencil-beam implementation of XFCT is not yet practical for routine in vivo imaging tasks with GNPs, especially in terms of scanning time. Nevertheless, with the use of multiple detectors and a limited number of projections, it may still be used to image some objects smaller than the current phantom size. The current investigation suggests several modification strategies of the current XFCT setup, such as the adoption of the quasi-monochromatic cone/fan x-ray beam and XFCT-specific spatial filters or pinhole detector collimators, in order to establish the ultimate feasibility of a bench-top XFCT system for GNP-based preclinical molecular imaging applications.

  10. X-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects using 110 kVp x-rays.

    Science.gov (United States)

    Cheong, Seong-Kyun; Jones, Bernard L; Siddiqi, Arsalan K; Liu, Fang; Manohar, Nivedh; Cho, Sang Hyun

    2010-02-07

    A conventional x-ray fluorescence computed tomography (XFCT) technique requires monochromatic synchrotron x-rays to simultaneously determine the spatial distribution and concentration of various elements such as metals in a sample. However, the synchrotron-based XFCT technique appears to be unsuitable for in vivo imaging under a typical laboratory setting. In this study we demonstrated, for the first time to our knowledge, the possibility of performing XFCT imaging of a small animal-sized object containing gold nanoparticles (GNPs) at relatively low concentrations using polychromatic diagnostic energy range x-rays. Specifically, we created a phantom made of polymethyl methacrylate plastic containing two cylindrical columns filled with saline solution at 1 and 2 wt% GNPs, respectively, mimicking tumors/organs within a small animal. XFCT scanning of the phantom was then performed using microfocus 110 kVp x-ray beam and cadmium telluride (CdTe) x-ray detector under a pencil beam geometry after proper filtering of the x-ray beam and collimation of the detector. The reconstructed images clearly identified the locations of the two GNP-filled columns with different contrast levels directly proportional to gold concentration levels. On the other hand, the current pencil-beam implementation of XFCT is not yet practical for routine in vivo imaging tasks with GNPs, especially in terms of scanning time. Nevertheless, with the use of multiple detectors and a limited number of projections, it may still be used to image some objects smaller than the current phantom size. The current investigation suggests several modification strategies of the current XFCT setup, such as the adoption of the quasi-monochromatic cone/fan x-ray beam and XFCT-specific spatial filters or pinhole detector collimators, in order to establish the ultimate feasibility of a bench-top XFCT system for GNP-based preclinical molecular imaging applications.

  11. 'Taking X-ray phase contrast imaging into mainstream applications' and its satellite workshop 'Real and reciprocal space X-ray imaging'.

    Science.gov (United States)

    Olivo, Alessandro; Robinson, Ian

    2014-03-06

    A double event, supported as part of the Royal Society scientific meetings, was organized in February 2013 in London and at Chicheley Hall in Buckinghamshire by Dr A. Olivo and Prof. I. Robinson. The theme that joined the two events was the use of X-ray phase in novel imaging approaches, as opposed to conventional methods based on X-ray attenuation. The event in London, led by Olivo, addressed the main roadblocks that X-ray phase contrast imaging (XPCI) is encountering in terms of commercial translation, for clinical and industrial applications. The main driver behind this is the development of new approaches that enable XPCI, traditionally a synchrotron method, to be performed with conventional laboratory sources, thus opening the way to its deployment in clinics and industrial settings. The satellite meeting at Chicheley Hall, led by Robinson, focused on the new scientific developments that have recently emerged at specialized facilities such as third-generation synchrotrons and free-electron lasers, which enable the direct measurement of the phase shift induced by a sample from intensity measurements, typically in the far field. The two events were therefore highly complementary, in terms of covering both the more applied/translational and the blue-sky aspects of the use of phase in X-ray research. 

  12. Nondestructive imaging of hidden figures on license plates by X-ray radiograph.

    Science.gov (United States)

    Jeon, Oc-Yeub; Kim, Sang-Hyeon; Lee, Joong; Park, Jong-Taek; Kim, Tae-Hoon; Park, Hak-Soo; Huh, Il-Kwon; Kang, Hyung-Tae

    2009-07-01

    In this case, we investigated the modified license plates. The evidences had new embossing pressed serial numbers after erasing the original numbers on the license plates by hammering. The X-ray radiograph could visualize the hidden figures; those were virtually unseen by naked eyes or undetectable by ordinary photography. To reveal the erased figures, we performed image processing with computer software after X-ray radiographs. It proved to be an efficient nondestructive way to visualize the hidden original figures on metals.

  13. The EOS 2D/3D X-ray imaging system

    OpenAIRE

    Faria, Rita; McKenna, Claire; Wade, Rosalind Fay; Yang, Huiqin; Woolacott, Nerys; Sculpher, Mark

    2013-01-01

    OBJECTIVES: To evaluate the cost-effectiveness of the EOS® 2D/3D X-ray imaging system compared with standard X-ray for the diagnosis and monitoring of orthopaedic conditions. MATERIALS AND METHODS: A decision analytic model was developed to quantify the long-term costs and health outcomes, expressed as quality-adjusted life years (QALYs) from the UK health service perspective. Input parameters were obtained from medical literature, previously developed cancer models and expert advice. Thresho...

  14. Integration of flat panel X-ray detector for high resolution diagnostic medical imaging

    Science.gov (United States)

    Kim, Min-Woo; Yun, Min-Seok; Kim, Yoon-Suk; Oh, Kyung-Min; Shin, Jung-Wook; Nam, Kyung-Tae; Nam, Sang-Hee

    2011-05-01

    In these days, flat panel X-ray image detectors have shown their potential for replacing traditional screen-film systems. To detect the X-ray photon energy, there are two main methods known as a direct method and an indirect method. The X-rays are converted immediately into electrical signal with the direct method. The indirect method has two conversion steps: the scintillator absorbs the X-rays and converts them to visible light. And then the visible light is converted to electrical signal (e.g. by photodiodes). In this work, the flat panel digital X-ray image detector based on direct method with a high atomic number material was designed and evaluated. The high atomic number material for X-ray conversion is deposited by a rubbing method with about 300 μm. The rubbing method is similar to the screen printing method. It consists of two elements: the screen and the squeegee. The method uses a proper stiff bar stretched tightly over a frame made of wood or metal. Proper tension is essential for proper laminated structure. The detector prototype has 139 μm pixel pitch, total 1280×1536 pixels and 86% fill factor. Twelve readout ICs are installed on digital X-ray detector and simultaneously operated to reach short readout time. The electronics integrated: the preamplifier to amplify generated signal, the Analog to Digital converter and the source of bias voltage (1 V/μm). The system board and interface use an NI-camera program. Finally, we achieved images from this flat panel X-ray image detector.

  15. Energy-resolved X-ray detectors: the future of diagnostic imaging

    OpenAIRE

    Pacella D

    2015-01-01

    Danilo Pacella ENEA-Frascati, Rome, Italy Abstract: This paper presents recent progress in the field of X-ray detectors, which could play a role in medical imaging in the near future, with special attention to the new generation of complementary metal-oxide semiconductor (C-MOS) imagers, working in photon counting, that opened the way to the energy-resolved X-ray imaging. A brief description of the detectors used so far in medical imaging (photographic films, imaging plates, flat panel detec...

  16. Fluid Dynamics (Science Press, Beijing, 2004).Design principles of a novel X-ray imaging system

    Institute of Scientific and Technical Information of China (English)

    Chunyu Yu; Benkang Chang; Shiyun Wang; Qingbao Wang

    2006-01-01

    @@ A novel X-ray imaging system (NXRIS) and the design principles are given in this paper. Different from the existing digital X-ray imaging systems, the X-ray image intensifying system of NXRIS is a non-vacuum system composed of the intensifying screen and the brightness intensifier, and the brightness intensifier is named low light level image intensifier applied in military affairs. This structure makes NXRIS of big visual field (15 inch, even to larger) and low cost. When designing NXRIS, the spectral compatibility of the component devices and the relation between the visual field and the spatial resolution of the component devices are analyzed. The images produced by NXRIS are given and the image performance is good enough to be applied to security checking, non-destructive testing, and industry detection.

  17. Novelty detection of foreign objects in food using multi-modal X-ray imaging

    DEFF Research Database (Denmark)

    Einarsdottir, Hildur; Emerson, Monica Jane; Clemmensen, Line Katrine Harder

    2016-01-01

    plastics not detectable by conventional X-ray absorption radiography. We conduct experiments, where several food products are imaged with common foreign objects typically found in the food processing industry. To evaluate the benefit from using this multi-contrast X-ray technique over conventional X......In this paper we demonstrate a method for novelty detection of foreign objects in food products using grating-based multimodal X-ray imaging. With this imaging technique three modalities are available with pixel correspondence, enhancing organic materials such as wood chips, insects and soft......-ray absorption imaging, a novelty detection scheme based on well known image- and statistical analysis techniques is proposed. The results show that the presented method gives superior recognition results and highlights the advantage of grating-based imaging....

  18. Quasi-stereoscopic imaging of the solar X-ray corona

    Science.gov (United States)

    Batchelor, David

    1994-01-01

    The first published three-dimensional images of the solar X-ray corona obtained by means of solar rotational parallax, are presented in stereographic form. Image pairs approximately 12 hours apart during times of stable coronal conditions were selected from the digitized images obtained with the Skylab X-ray Spectrographic Telescope. The image resolution limit is approximately 10 arc sec. Many coronal structures not visible in the separate images are clearly observed when the image pairs are viewed stereoscopically. This method gives a preview of the potential resources for solar research and forecasting of solar-geomagnetic interactions that could be provided by stereoscopic observations of the Sun using a small group of spacecraft. The method is also applicable to other X-ray, ultraviolet, or other wavebands in which the corona has extended, transparent structure.

  19. Imaging nanoscale lattice variations by machine learning of x-ray diffraction microscopy data

    Science.gov (United States)

    Laanait, Nouamane; Zhang, Zhan; Schlepütz, Christian M.

    2016-09-01

    We present a novel methodology based on machine learning to extract lattice variations in crystalline materials, at the nanoscale, from an x-ray Bragg diffraction-based imaging technique. By employing a full-field microscopy setup, we capture real space images of materials, with imaging contrast determined solely by the x-ray diffracted signal. The data sets that emanate from this imaging technique are a hybrid of real space information (image spatial support) and reciprocal lattice space information (image contrast), and are intrinsically multidimensional (5D). By a judicious application of established unsupervised machine learning techniques and multivariate analysis to this multidimensional data cube, we show how to extract features that can be ascribed physical interpretations in terms of common structural distortions, such as lattice tilts and dislocation arrays. We demonstrate this ‘big data’ approach to x-ray diffraction microscopy by identifying structural defects present in an epitaxial ferroelectric thin-film of lead zirconate titanate.

  20. A broadband x-ray imaging spectroscopy with high-angular resolution: the FORCE mission

    Science.gov (United States)

    Mori, Koji; Tsuru, Takeshi Go; Nakazawa, Kazuhiro; Ueda, Yoshihiro; Okajima, Takashi; Murakami, Hiroshi; Awaki, Hisamitsu; Matsumoto, Hironori; Fukazawa, Yasushi; Tsunemi, Hiroshi; Takahashi, Tadayuki; Zhang, William W.

    2016-07-01

    We are proposing FORCE (Focusing On Relativistic universe and Cosmic Evolution) as a future Japan-lead Xray observatory to be launched in the mid 2020s. Hitomi (ASTRO-H) possesses a suite of sensitive instruments enabling the highest energy-resolution spectroscopy in soft X-ray band, a broadband X-ray imaging spectroscopy in soft and hard X-ray bands, and further high energy coverage up to soft gamma-ray band. FORCE is the direct successor to the broadband X-ray imaging spectroscopy aspect of Hitomi (ASTRO-H) with significantly higher angular resolution. The current design of FORCE defines energy band pass of 1-80 keV with angular resolution of black holes" in various mass-scales: "buried supermassive black holes (SMBHs)" (> 104 M⊙) residing in the center of galaxies in a cosmological distance, "intermediate-mass black holes" (102-104 M⊙) acting as the possible seeds from which SMBHs grow, and "orphan stellar-mass black holes" (mirror and wide-band X-ray detector. The focal length is currently planned to be 10 m. The silicon mirror with multi-layer coating is our primary choice to achieve lightweight, good angular optics. The detector is a descendant of hard X-ray imager onboard Hitomi (ASTRO-H) replacing its silicon strip detector with SOI-CMOS silicon pixel detector, allowing an extension of the low energy threshold down to 1 keV or even less.

  1. In-laboratory diffraction-enhanced X-ray imaging for articular cartilage.

    Science.gov (United States)

    Muehleman, Carol; Fogarty, Daniel; Reinhart, Benjamin; Tzvetkov, Tochko; Li, Jun; Nesch, Ivan

    2010-07-01

    The loss of articular cartilage characteristic of osteoarthritis can only be diagnosed by joint space narrowing when conventional radiography is used. This is due to the lack of X-ray contrast of soft tissues. Whereas conventional radiography harnesses the X-ray attenuation properties of tissues, Diffraction Enhanced Imaging (DEI), a novel radiographic technique, allows the visualization of soft tissues simultaneous with calcified tissues by virtue of its ability to not only harness X-ray attenuation but also the X-ray refraction from tissue boundaries. Previously, DEI was dependent upon synchrotron X-rays, but more recently, the development of nonsynchrotron DEI units has been explored. These developments serve to elaborate the full potential of radiography. Here, we tested the potential of an in-laboratory DEI system, called Diffraction-Enhanced X-ray Imaging (DEXI), to render images of articular cartilage displaying varying degrees of degradation, ex vivo. DEXI allowed visualization of even early stages of cartilage degeneration such as surface fibrillation. This may be of eventual clinical significance for the diagnosis of early stages of degeneration, or at the very least, to visualize soft tissue degeneration simultaneous with bone changes.

  2. Investigating high speed phenomena in laser plasma interactions using dilation x-ray imager (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Nagel, S. R., E-mail: nagel7@llnl.gov; Bell, P. M.; Bradley, D. K.; Ayers, M. J.; Piston, K.; Felker, B. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550 (United States); Hilsabeck, T. J.; Kilkenny, J. D.; Chung, T.; Sammuli, B. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Hares, J. D.; Dymoke-Bradshaw, A. K. L. [Kentech Instruments Ltd., Wallingford, Oxfordshire OX10 (United Kingdom)

    2014-11-15

    The DIlation X-ray Imager (DIXI) is a new, high-speed x-ray framing camera at the National Ignition Facility (NIF) sensitive to x-rays in the range of ≈2–17 keV. DIXI uses the pulse-dilation technique to achieve a temporal resolution of less than 10 ps, a ≈10× improvement over conventional framing cameras currently employed on the NIF (≈100 ps resolution), and otherwise only attainable with 1D streaked imaging. The pulse-dilation technique utilizes a voltage ramp to impart a velocity gradient on the signal-bearing electrons. The temporal response, spatial resolution, and x-ray sensitivity of DIXI are characterized with a short x-ray impulse generated using the COMET laser facility at Lawrence Livermore National Laboratory. At the NIF a pinhole array at 10 cm from target chamber center (tcc) projects images onto the photocathode situated outside the NIF chamber wall with a magnification of ≈64×. DIXI will provide important capabilities for warm-dense-matter physics, high-energy-density science, and inertial confinement fusion, adding important capabilities to temporally resolve hot-spot formation, x-ray emission, fuel motion, and mix levels in the hot-spot at neutron yields of up to 10{sup 17}. We present characterization data as well as first results on electron-transport phenomena in buried-layer foil experiments.

  3. X-ray image calibration and its application to clinical orthopedics.

    Science.gov (United States)

    Schumann, Steffen; Thelen, Benedikt; Ballestra, Steven; Nolte, Lutz-P; Büchler, Philippe; Zheng, Guoyan

    2014-07-01

    X-ray imaging is one of the most commonly used medical imaging modality. Albeit X-ray radiographs provide important clinical information for diagnosis, planning and post-operative follow-up, the challenging interpretation due to its 2D projection characteristics and the unknown magnification factor constrain the full benefit of X-ray imaging. In order to overcome these drawbacks, we proposed here an easy-to-use X-ray calibration object and developed an optimization method to robustly find correspondences between the 3D fiducials of the calibration object and their 2D projections. In this work we present all the details of this outlined concept. Moreover, we demonstrate the potential of using such a method to precisely extract information from calibrated X-ray radiographs for two different orthopedic applications: post-operative acetabular cup implant orientation measurement and 3D vertebral body displacement measurement during preoperative traction tests. In the first application, we have achieved a clinically acceptable accuracy of below 1° for both anteversion and inclination angles, where in the second application an average displacement of 8.06±3.71 mm was measured. The results of both applications indicate the importance of using X-ray calibration in the clinical routine.

  4. Investigating high speed phenomena in laser plasma interactions using dilation x-ray imager (invited).

    Science.gov (United States)

    Nagel, S R; Hilsabeck, T J; Bell, P M; Bradley, D K; Ayers, M J; Piston, K; Felker, B; Kilkenny, J D; Chung, T; Sammuli, B; Hares, J D; Dymoke-Bradshaw, A K L

    2014-11-01

    The DIlation X-ray Imager (DIXI) is a new, high-speed x-ray framing camera at the National Ignition Facility (NIF) sensitive to x-rays in the range of ≈2-17 keV. DIXI uses the pulse-dilation technique to achieve a temporal resolution of less than 10 ps, a ≈10× improvement over conventional framing cameras currently employed on the NIF (≈100 ps resolution), and otherwise only attainable with 1D streaked imaging. The pulse-dilation technique utilizes a voltage ramp to impart a velocity gradient on the signal-bearing electrons. The temporal response, spatial resolution, and x-ray sensitivity of DIXI are characterized with a short x-ray impulse generated using the COMET laser facility at Lawrence Livermore National Laboratory. At the NIF a pinhole array at 10 cm from target chamber center (tcc) projects images onto the photocathode situated outside the NIF chamber wall with a magnification of ≈64×. DIXI will provide important capabilities for warm-dense-matter physics, high-energy-density science, and inertial confinement fusion, adding important capabilities to temporally resolve hot-spot formation, x-ray emission, fuel motion, and mix levels in the hot-spot at neutron yields of up to 10(17). We present characterization data as well as first results on electron-transport phenomena in buried-layer foil experiments.

  5. Closed-bore XMR (CBXMR) systems for aortic valve replacement: X-ray tube imaging performance

    Energy Technology Data Exchange (ETDEWEB)

    Bracken, John A.; Komljenovic, Philip; Lillaney, Prasheel V.; Fahrig, Rebecca; Rowlands, J. A. [Department of Medical Biophysics and Sunnybrook Health Sciences Center, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Canada); Department of Radiology, Stanford University, Stanford, California 94305 (United States); Department of Medical Biophysics and Sunnybrook Health Sciences Center, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Canada)

    2009-04-15

    A hybrid closed-bore x-ray/MRI system (CBXMR) is proposed to improve the safety and efficacy of percutaneous aortic valve replacement procedures. In this system, an x-ray C-arm will be positioned about 1 m from the entrance of a 1.5 T MRI scanner. The CBXMR system will harness the complementary strengths of both modalities to guide and deploy a bioprosthetic valve into the aortic annulus of the heart without coronary artery obstruction. A major challenge in constructing this system is ensuring proper operation of a rotating-anode x-ray tube in the MRI magnetic fringe field environment. The electron beam in the x-ray tube responsible for producing x rays can be deflected by the fringe field. However, the clinical impact of electron beam deflection in a magnetic field has not yet been studied. Here, the authors investigated changes in focal spot resolving power, field of view shift, and field of view truncation in x-ray images as a result of electron beam deflection. The authors found that in the fringe field acting on the x-ray tube at the clinical location for the x-ray C-arm (4 mT), focal spot size increased by only 2%, so the fringe field did not limit the resolving power of the x-ray system. The magnetic field also caused the field of view to shift by 3 mm. This shift must be corrected to avoid unnecessary primary radiation exposure to the patient and the staff in the cardiac catheterization laboratory. The fringe field was too weak to cause field of view truncation.

  6. Micro-imaging of buried layers and interfaces in ultrathin films by X-ray reflectivity

    Science.gov (United States)

    Jiang, Jinxing; Hirano, Keiichi; Sakurai, Kenji

    2016-09-01

    X-ray reflectivity is a promising technique for characterizing buried layers and interfaces in ultrathin films because of its ability to probe the electron density profile along the depth in a non-destructive manner. While routine X-ray reflectivity assumes the in-plane uniformity of the sample to be measured, it is also quite important to see buried inhomogeneous/patterned layers and interfaces. The present paper describes the addition of spatial resolution and imaging capability to an X-ray reflectivity technique to visualize surfaces and buried interfaces. To visualize quite wide viewing area size quickly, the image reconstruction scheme has been employed instead of the scanning of microbeam. Though the mathematics is quite close to X-ray computer tomography, the technique gives the image contrast caused by the difference in reflectivity at each in-plane point in the thin film sample. By choosing a grazing angle, the image gives inhomogeneity of X-ray reflectivity at the specific wavevector transfer. With a collimated monochromatic synchrotron X-ray beam of 0.05 mm (H) × 8 mm (V), the intensity profiles of X-ray reflection projections have been taken at many different in-plane rotation angles, from 0° to 180°. We have succeeded in visualizing buried layers and interfaces of the 8 mm dia area with the spatial resolution of better than 20 μm. Because of the brilliance of synchrotron radiation, the typical measuring time is shorter than 1 min. Three analytical cases have been discussed: (i) imaging of a buried layer and an interface covered by a protection layer, (ii) distinguishing different local parts of different thicknesses in an ultrathin film, and (iii) selective imaging of a specific metal in the thin film form.

  7. X-ray Phase Imaging Microscopy with Two-Dimensional Knife-Edge Filters

    Science.gov (United States)

    Choi, Jaeho; Park, Yong-Sung

    2012-04-01

    A novel scheme of X-ray differential phase imaging was implemented with an array source and a two-dimensional Foucault knife-edge (2DFK). A pinhole array lens was employed to manipulate the X-ray beam on the Fourier space. An emerging biaxial scanning procedure was also demonstrated with the periodic 2DFK. The differential phase images (DPIs) of the midrib in a leaf of a rose bush were visualized to verify the phase imaging of biological specimens by the proposed method. It also has features of depicting multiple-stack phase images, and rendering morphological DPIs, because it acquires pure phase information.

  8. A low cost X-ray imaging device based on BPW-34 Si-PIN photodiode

    Energy Technology Data Exchange (ETDEWEB)

    Emirhan, E.; Bayrak, A.; Yücel, E. Barlas; Yücel, M.; Ozben, C.S., E-mail: ozben@itu.edu.tr

    2016-05-21

    A low cost X-ray imaging device based on BPW-34 silicon PIN photodiode was designed and produced. X-rays were produced from a CEI OX/70-P dental tube using a custom made ±30 kV power supply. A charge sensitive preamplifier and a shaping amplifier were built for the amplification of small signals produced by photons in the depletion layer of Si-PIN photodiode. A two dimensional position control unit was used for moving the detector in small steps to measure the intensity of X-rays absorbed in the object to be imaged. An Aessent AES220B FPGA module was used for transferring the image data to a computer via USB. Images of various samples were obtained with acceptable image quality despite of the low cost of the device.

  9. The Study on the Attenuation of X-ray and Imaging Quality by Contents in Stomach

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Kyung Rae; Ji, Youn Sang; Kim, Chang Bok; Choi, Seong Kwan; Moon, Sang In [Dept. of Radiological Technology, Gwangju Health College University, Gwangju (Korea, Republic of); Dieter, Kevin [Dept. of Physical Therapy, Gwangju Health College University, Gwangju (Korea, Republic of)

    2009-03-15

    This study examined the change in the attenuation of X-rays with the ROI (Region of Interest) in DR (Digital Radiography) according to the stomach contents by manufacturing a tissue equivalent material phantom to simulate real stomach tissue based on the assumption that there is some attenuation of X-rays and a difference in imaging quality according to the stomach contents. The transit dosage by the attenuation of X-rays decreased with increasing protein thickness, which altered the average ROI values in the film and DR images. A comparison of the change in average ROI values of the film and DR image showed that the image in film caused larger density changes with varying thickness of protein than the image by DR. The results indicate that NPO (nothing by mouth) is more important in film system than in DR system.

  10. Soft x-ray source for nanostructure imaging using femtosecond-laser-irradiated clusters

    Science.gov (United States)

    Fukuda, Y.; Faenov, A. Ya.; Pikuz, T.; Kando, M.; Kotaki, H.; Daito, I.; Ma, J.; Chen, L. M.; Homma, T.; Kawase, K.; Kameshima, T.; Kawachi, T.; Daido, H.; Kimura, T.; Tajima, T.; Kato, Y.; Bulanov, S. V.

    2008-03-01

    The intense soft x-ray light source using the supersonic expansion of the mixed gas of He and CO2, when irradiated by a femtosecond Ti:sapphire laser pulse, is observed to enhance the radiation of soft x-rays from the CO2 clusters. Using this soft x-ray emissions, nanostructure images of 100-nm-thick Mo foils in a wide field of view (mm2 scale) with high spatial resolution (800nm ) are obtained with high dynamic range LiF crystal detectors. The local inhomogeneities of soft x-ray absorption by the nanometer-thick foils is measured with an accuracy of less than ±3%.

  11. Impact of ultrafast electronic damage in single particle x-ray imaging experiments

    CERN Document Server

    Lorenz, U; Weckert, E; Vartanyants, I A

    2012-01-01

    In single particle coherent x-ray diffraction imaging experiments, performed at x-ray free-electron lasers (XFELs), samples are exposed to intense x-ray pulses to obtain single-shot diffraction patterns. The high intensity induces electronic dynamics on the femtosecond time scale in the system, which can reduce the contrast of the obtained diffraction patterns and adds an isotropic background. We quantify the degradation of the diffraction pattern from ultrafast electronic damage by performing simulations on a biological sample exposed to x-ray pulses with different parameters. We find that the contrast is substantially reduced and the background is considerably strong only if almost all electrons are removed from their parent atoms. This happens at fluences of at least one order of magnitude larger than provided at currently available XFEL sources.

  12. A dedicated endstation for waveguide-based X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kalbfleisch, Sebastian

    2013-07-01

    X-ray microscopy has emerged as a powerful and versatile imaging technique in many fields of science over the last years, offering insights in opaque media at high spatial resolution. A major challenge remains the fabrication of suitable X-ray lenses, e.g., Fresnel zone plates or compound refractive lenses. In an alternative approach of a lensless imaging scheme the sample is illuminated by a coherent X-ray beam. The sample information is then reconstructed from the recorded diffraction signal by numerical iterative algorithms. Within this thesis the basics of lensless holographic imaging with X-Ray waveguides are summarised and extended to the concept of waveguide-based X-ray interferometry. The specific instrumentation required for the conceptual experiments of waveguidebased holographic imaging is explained and illustrated by the obtained results. Based on the results of these conceptual experiments a dedicated synchrotron endstation for waveguide-based holographic imaging was designed and built. The specifications and properties of the Kirkpatrick-Baez focussing mirrors and other mechanical and optical components are described in detail, along with the instrument control system and various available detectors. First commissioning results prove the imaging abilities of the presented endstation.

  13. Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging

    Science.gov (United States)

    Baran, P.; Pacile, S.; Nesterets, Y. I.; Mayo, S. C.; Dullin, C.; Dreossi, D.; Arfelli, F.; Thompson, D.; Lockie, D.; McCormack, M.; Taba, S. T.; Brun, F.; Pinamonti, M.; Nickson, C.; Hall, C.; Dimmock, M.; Zanconati, F.; Cholewa, M.; Quiney, H.; Brennan, P. C.; Tromba, G.; Gureyev, T. E.

    2017-03-01

    The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contrast mammographic tomography method, which incorporates not only absorption, but also x-ray phase information. In this study the images of breast tissue samples, of a size corresponding to a full human breast, with radiologically acceptable x-ray doses were obtained, and the degree of improvement of the image quality (from the diagnostic point of view) achievable using propagation-based phase-contrast image acquisition protocols with proper incorporation of x-ray phase retrieval into the reconstruction pipeline was investigated. Parameters such as the x-ray energy, sample-to-detector distance and data processing methods were tested, evaluated and optimized with respect to the estimated diagnostic value using a mastectomy sample with a malignant lesion. The results of quantitative evaluation of images were obtained by means of radiological assessment carried out by 13 experienced specialists. A comparative analysis was performed between the x-ray and the histological images of the specimen. The results of the analysis indicate that, within the investigated range of parameters, both the objective image quality characteristics and the subjective radiological scores of propagation-based phase-contrast images of breast tissues monotonically increase with the strength of phase contrast which in turn is directly proportional to the product of the radiation wavelength and the sample-to-detector distance. The outcomes of this study serve to define the practical imaging conditions and the CT reconstruction procedures appropriate for low-dose phase-contrast mammographic imaging of live patients at specially designed synchrotron beamlines.

  14. Breast density mapping based upon system calibration, x-ray techniques, and FFDM images

    Science.gov (United States)

    Chen, Biao; Smith, Andrew P.; Jing, Zhenxue; Wu, Tao

    2007-03-01

    Clinical studies have correlated a high breast density to a women's risk of breast cancer. A breast density measurement that can quantitatively depict the volume distribution and percentage of dense tissues in breasts would be very useful for risk factor assessment of breast cancer, and might be more predictive of risks than the common but subjective and coarse 4-point BIRADS scale. This paper proposes to use a neural-network mapping to compute the breast density information based upon system calibration data, x-ray techniques, and Full Field Digital Mammography (FFDM) images. The mapping consists of four modules, namely, system calibration, generator of beam quality, generator of normalized absorption, and a multi-layer feed-forward neural network. As the core of breast density mapping, the network accepts x-ray target/filter combination, normalized x-ray absorption, pixel-wise breast thickness map, and x-ray beam quality during image acquisition as input elements, and exports a pixel-wise breast density distribution and a single breast density percentage for the imaged breast. Training and testing data sets for the design and verification of the network were formulated from calibrated x-ray beam quality, imaging data with a step wedge phantom under a variety x-ray imaging techniques, and nominal breast densities of tissue equivalent materials. The network was trained using a Levenberg-Marquardt algorithm based back-propagation learning method. Various thickness and glandular density phantom studies were performed with clinical x-ray techniques. Preliminary results showed that the neural network mapping is promising in accurately computing glandular density distribution and breast density percentage.

  15. Multiframe, Single Line-of-Sight X-Ray Imager for Burning Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Kevin L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-01-28

    The purpose of this LDRD project was to demonstrate high spatial and temporal resolution x-ray imaging using optical detectors, and in particular the VISAR and OHRV diagnostics on the OMEGA laser. The x-ray source being imaged was a backlighter capsule being imploded by 39 beams of the OMEGA laser. In particular this approach utilized a semiconductor with the side facing the backlighter capsule coated with a thin aluminum layer to allow x rays to pass through the metal layer and then get absorbed in the semiconductor. The other side of the semiconductor was AR coated to allow the VISAR or OHRV probe beam to sample the phase change of the semiconductor as the x rays were absorbed in the semiconductor. This technique is capable of acquiring sub-picosecond 2-D or 1-D x-ray images, detector spatial resolution of better than 10 um and the ability to operate in a high neutron flux environment expected on ignition shots with burning plasmas. In addition to demonstrating this technique on the OMEGA laser, several designs were made to improve the phase sensitivity, temporal resolution and number of frames over the existing diagnostics currently implemented on the OMEGA laser. These designs included both 2-d imaging diagnostics as well as improved 1-D imaging diagnostics which were streaked in time.

  16. Imaging of metastatic lymph nodes by X-ray phase-contrast micro-tomography.

    Directory of Open Access Journals (Sweden)

    Torben Haugaard Jensen

    Full Text Available Invasive cancer causes a change in density in the affected tissue, which can be visualized by x-ray phase-contrast tomography. However, the diagnostic value of this method has so far not been investigated in detail. Therefore, the purpose of this study was, in a blinded manner, to investigate whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37-83 years diagnosed with invasive ductal carcinomas were analyzed by X-ray phase-contrast tomography. Ten lymph nodes had metastatic deposits and 7 were benign. The phase-contrast images were analyzed according to standards for conventional CT images looking for characteristics usually only visible by pathological examinations. Histopathology was used as reference. The result of this study was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations to obtain information regarding lymph node involvement previously inaccessible with standard absorption x-ray imaging.

  17. X-ray modulation transfer functions of photostimulable phosphor image plates and scanners.

    Science.gov (United States)

    Seely, John F; Holland, Glenn E; Hudson, Lawrence T; Henins, Albert

    2008-11-01

    The modulation transfer functions of two types of photostimulable phosphor image plates were determined in the 10 keV to 50 keV x-ray energy range using a resolution test pattern with up to 10 line pairs per mm (LP/mm) and a wavelength dispersive x-ray spectrometer. Techniques were developed for correcting for the partial transmittance of the high energy x rays through the lead bars of the resolution test pattern, and the modulation transfer function (MTF) was determined from the measured change in contrast with LP/mm values. The MTF was convolved with the slit function of the image plate scanner, and the resulting point spread functions (PSFs) were in good agreement with the observed shapes and widths of x-ray spectral lines and with the PSF derived from edge spread functions. The shapes and the full width at half-maximum (FWHM) values of the PSF curves of the Fuji Superior Resolution (SR) and Fuji Maximum Sensitivity (MS) image plate detectors, consisting of the image plate and the scanner, determined by the three methods gave consistent results: The SR PSF is Gaussian with 0.13 mm FWHM, and the MS PSF is Lorentzian with 0.19 mm FWHM. These techniques result in the accurate determination of the spatial resolution achievable using image plate and scanner combinations and enable the optimization of spatial resolution for x-ray spectroscopy and radiography.

  18. X-ray photon-in/photon-out methods for chemical imaging

    Energy Technology Data Exchange (ETDEWEB)

    Marcus, Matthew A.

    2010-03-24

    Most interesting materials in nature are heterogeneous, so it is useful to have analytical techniques with spatial resolution sufficient to resolve these heterogeneities.This article presents the basics of X-ray photon-in/photon-out chemical imaging. This family of methods allows one to derive images reflectingthe chemical state of a given element in a complex sample, at micron or deep sub-micron scale. X-ray chemical imaging is relatively non-destructiveand element-selective, and requires minimal sample preparation. The article presents the basic concepts and some considerations of data takingand data analysis, along with some examples.

  19. Microfocus x-ray imaging of traceable pointlike {sup 22}Na sources for quality control

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, T.; Oda, K.; Sato, Y.; Ito, H.; Masuda, S.; Yamada, T.; Matsumoto, M.; Murayama, H.; Takei, H. [Allied Health Sciences, Kitasato University Kitasato 1-15-1, Minami-ku, Sagamihara-shi, Kanagawa 252-0373 (Japan); Positron Medical Center, Tokyo Metropolitan Institute of Gerontology Sakaecho 35-2, Itabashi-ku, Tokyo 173-0015 (Japan); Advanced Industrial Science and Technology (AIST) Central 2, Umezono 1-1-1, Tsukuba-shi, Ibaraki 305-8568 (Japan); Kanagawa Industrial Technology Center (KITC) Shimoimazumi 705-1, Ebina-shi, Kanagawa 243-0435 (Japan); Japan Radioisotope Association (JRIA) Komagome 2-28-45, Bunkyo-ku, Tokyo 113-8941 (Japan); Molecular Imaging Center, National Institute of Radiological Sciences Anagawa 4-9-1, Inage, Chiba 263-8555 (Japan); Graduate School of Medical Sciences, Kitasato University Kitasato 1-15-1, Minami-ku, Sagamihara-shi, Kanagawa 252-0373 (Japan)

    2012-07-15

    Purpose: The purpose of this study is to propose a microfocus x-ray imaging technique for observing the internal structure of small radioactive sources and evaluating geometrical errors quantitatively, and to apply this technique to traceable pointlike {sup 22}Na sources, which were designed for positron emission tomography calibration, for the purpose of quality control of the pointlike sources. Methods: A microfocus x-ray imaging system with a focus size of 0.001 mm was used to obtain projection x-ray images and x-ray CT images of five pointlike source samples, which were manufactured during 2009-2012. The obtained projection and tomographic images were used to observe the internal structure and evaluate geometrical errors quantitatively. Monte Carlo simulation was used to evaluate the effect of possible geometrical errors on the intensity and uniformity of 0.511 MeV annihilation photon pairs emitted from the sources. Results: Geometrical errors were evaluated with sufficient precision using projection x-ray images. CT images were used for observing the internal structure intuitively. As a result, four of the five examined samples were within the tolerance to maintain the total uncertainty below {+-}0.5%, given the source radioactivity; however, one sample was found to be defective. Conclusions: This quality control procedure is crucial and offers an important basis for using the pointlike {sup 22}Na source as a basic calibration tool. The microfocus x-ray imaging approach is a promising technique for visual and quantitative evaluation of the internal geometry of small radioactive sources.

  20. X-ray phase computed tomography for nanoparticulated imaging probes and therapeutics: preliminary feasibility study

    Science.gov (United States)

    Tang, Xiangyang; Yang, Yi; Tang, Shaojie

    2011-03-01

    With the scientific progress in cancer biology, pharmacology and biomedical engineering, the nano-biotechnology based imaging probes and therapeutical agents (namely probes/agents) - a form of theranostics - are among the strategic solutions bearing the hope for the cure of cancer. The key feature distinguishing the nanoparticulated probes/agents from their conventional counterparts is their targeting capability. A large surface-to-volume ratio in nanoparticulated probes/agents enables the accommodation of multiple targeting, imaging and therapeutic components to cope with the intra- and inter-tumor heterogeneity. Most nanoparticulated probes/agents are synthesized with low atomic number materials and thus their x-ray attenuation are very similar to biological tissues. However, their microscopic structures are very different, which may result in significant differences in their refractive properties. Recently, the investigation in the x-ray grating-based differential phase contrast (DPC) CT has demonstrated its advantages in differentiating low-atomic materials over the conventional attenuation-based CT. We believe that a synergy of x-ray grating-based DPC CT and nanoparticulated imaging probes and therapeutic agents may play a significant role in extensive preclinical and clinical applications, or even become a modality for molecular imaging. Hence, we propose to image the refractive property of nanoparticulated imaging probes and therapeutical agents using x-ray grating-based DPC CT. In this work, we conduct a preliminary feasibility study with a focus to characterize the contrast-to-noise ratio (CNR) and contrast-detail behavior of the x-ray grating-based DPC CT. The obtained data may be instructive to the architecture design and performance optimization of the x-ray grating-based DPC CT for imaging biomarker-targeted imaging probes and therapeutic agents, and even informative to the translation of preclinical research in theranostics into clinical applications.

  1. Three-dimensional imaging of nanoscale materials by using coherent x-rays

    Energy Technology Data Exchange (ETDEWEB)

    Miao, Jianwei

    2011-04-18

    X-ray crystallography is currently the primary methodology used to determine the 3D structure of materials and macromolecules. However, many nanostructures, disordered materials, biomaterials, hybrid materials and biological specimens are noncrystalline and, hence, their structures are not accessible by X-ray crystallography. Probing these structures therefore requires the employment of different approaches. A very promising technique currently under rapid development is X-ray diffraction microscopy (or lensless imaging), in which the coherent X-ray diffraction pattern of a noncrystalline specimen is measured and then directly phased to obtain a high-resolution image. Through the DOE support over the past three years, we have applied X-ray diffraction microscopy to quantitative imaging of GaN quantum dot particles, and revealed the internal GaN-Ga2O3 core shell structure in three dimensions. By exploiting the abrupt change in the scattering cross-section near electronic resonances, we carried out the first experimental demonstration of resonant X-ray diffraction microscopy for element specific imaging. We performed nondestructive and quantitative imaging of buried Bi structures inside a Si crystal by directly phasing coherent X-ray diffraction patterns acquired below and above the Bi M5 edge. We have also applied X-ray diffraction microscopy to nondestructive imaging of mineral crystals inside biological composite materials - intramuscular fish bone - at the nanometer scale resolution. We identified mineral crystals in collagen fibrils at different stages of mineralization and proposed a dynamic mechanism to account for the nucleation and growth of mineral crystals in the collagen matrix. In addition, we have also discovered a novel 3D imaging modality, denoted ankylography, which allows for complete 3D structure determination without the necessity of sample titling or scanning. We showed that when the diffraction pattern of a finite object is sampled at a

  2. Fundamental x-ray interaction limits in diagnostic imaging detectors: spatial resolution.

    Science.gov (United States)

    Hajdok, G; Battista, J J; Cunningham, I A

    2008-07-01

    The practice of diagnostic x-ray imaging has been transformed with the emergence of digital detector technology. Although digital systems offer many practical advantages over conventional film-based systems, their spatial resolution performance can be a limitation. The authors present a Monte Carlo study to determine fundamental resolution limits caused by x-ray interactions in four converter materials: Amorphous silicon (a-Si), amorphous selenium, cesium iodide, and lead iodide. The "x-ray interaction" modulation transfer function (MTF) was determined for each material and compared in terms of the 50% MTF spatial frequency and Wagner's effective aperture for incident photon energies between 10 and 150 keV and various converter thicknesses. Several conclusions can be drawn from their Monte Carlo study. (i) In low-Z (a-Si) converters, reabsorption of Compton scatter x rays limits spatial resolution with a sharp MTF drop at very low spatial frequencies (x rays plays a dominant role, resulting in a mid-frequency (1-5 cycles/mm) MTF drop. (ii) Coherent scatter plays a minor role in the x-ray interaction MTF. (iii) The spread of energy due to secondary electron (e.g., photoelectrons) transport is significant only at very high spatial frequencies. (iv) Unlike the spread of optical light in phosphors, the spread of absorbed energy from x-ray interactions does not significantly degrade spatial resolution as converter thickness is increased. (v) The effective aperture results reported here represent fundamental spatial resolution limits of the materials tested and serve as target benchmarks for the design and development of future digital x-ray detectors.

  3. Rapid, low dose X-ray diffractive imaging of the malaria parasite Plasmodium falciparum

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Michael W.M., E-mail: michael.jones@latrobe.edu.au [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Dearnley, Megan K. [ARC Centre of Excellence for Coherent X-Ray Science, Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, Victoria 3010 (Australia); Riessen, Grant A. van [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Abbey, Brian [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Melbourne Centre for Nanofabrication, Victoria 3168 (Australia); Putkunz, Corey T. [ARC Centre of Excellence for Coherent X-Ray Science, School of Physics, The University of Melbourne, Victoria 3010 (Australia); Junker, Mark D. [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Vine, David J. [Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439 (United States); McNulty, Ian [Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439 (United States); Centre for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Nugent, Keith A. [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Peele, Andrew G. [ARC Centre of Excellence for Coherent X-Ray Science, Department of Physics, La Trobe University, Victoria 3086 (Australia); Australian Synchrotron, 800 Blackburn Road, Clayton 3168 (Australia); Tilley, Leann [ARC Centre of Excellence for Coherent X-Ray Science, Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, Victoria 3010 (Australia)

    2014-08-01

    Phase-diverse X-ray coherent diffractive imaging (CDI) provides a route to high sensitivity and spatial resolution with moderate radiation dose. It also provides a robust solution to the well-known phase-problem, making on-line image reconstruction feasible. Here we apply phase-diverse CDI to a cellular sample, obtaining images of an erythrocyte infected by the sexual stage of the malaria parasite, Plasmodium falciparum, with a radiation dose significantly lower than the lowest dose previously reported for cellular imaging using CDI. The high sensitivity and resolution allow key biological features to be identified within intact cells, providing complementary information to optical and electron microscopy. This high throughput method could be used for fast tomographic imaging, or to generate multiple replicates in two-dimensions of hydrated biological systems without freezing or fixing. This work demonstrates that phase-diverse CDI is a valuable complementary imaging method for the biological sciences and ready for immediate application. - Highlights: • Phase-diverse coherent X-ray diffraction microscopy provides high-resolution and high-contrast images of intact biological samples. • Rapid nanoscale resolution imaging is demonstrated at orders of magnitude lower dose than previously possible. • Phase-diverse coherent X-ray diffraction microscopy is a robust technique for rapid, quantitative, and correlative X-ray phase imaging.

  4. X-Ray image denoising with directional support value transform

    NARCIS (Netherlands)

    Zheng, S.; Hendriks, E.A.; Lei, B.; Hao, W.

    2009-01-01

    Under the support vector machine framework, the support value analysis-based image fusion has been studied, where the salient features of the original images are represented by their support values. The support value transform (SVT)-based image fusion approach have demonstrated some advantages over

  5. New developments of X-ray fluorescence imaging techniques in laboratory

    Science.gov (United States)

    Tsuji, Kouichi; Matsuno, Tsuyoshi; Takimoto, Yuki; Yamanashi, Masaki; Kometani, Noritsugu; Sasaki, Yuji C.; Hasegawa, Takeshi; Kato, Shuichi; Yamada, Takashi; Shoji, Takashi; Kawahara, Naoki

    2015-11-01

    X-ray fluorescence (XRF) analysis is a well-established analytical technique with a long research history. Many applications have been reported in various fields, such as in the environmental, archeological, biological, and forensic sciences as well as in industry. This is because XRF has a unique advantage of being a nondestructive analytical tool with good precision for quantitative analysis. Recent advances in XRF analysis have been realized by the development of new x-ray optics and x-ray detectors. Advanced x-ray focusing optics enables the making of a micro x-ray beam, leading to micro-XRF analysis and XRF imaging. A confocal micro-XRF technique has been applied for the visualization of elemental distributions inside the samples. This technique was applied for liquid samples and for monitoring chemical reactions such as the metal corrosion of steel samples in the NaCl solutions. In addition, a principal component analysis was applied for reducing the background intensity in XRF spectra obtained during XRF mapping, leading to improved spatial resolution of confocal micro-XRF images. In parallel, the authors have proposed a wavelength dispersive XRF (WD-XRF) imaging spectrometer for a fast elemental imaging. A new two dimensional x-ray detector, the Pilatus detector was applied for WD-XRF imaging. Fast XRF imaging in 1 s or even less was demonstrated for Euro coins and industrial samples. In this review paper, these recent advances in laboratory-based XRF imaging, especially in a laboratory setting, will be introduced.

  6. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... drawer under the table holds the x-ray film or image recording plate . Sometimes the x-ray ... extended over the patient while an x-ray film holder or image recording plate is placed beneath ...

  7. The geometry of three-dimensional measurement from paired coplanar x-ray images.

    Science.gov (United States)

    Baumrind, S; Moffitt, F H; Curry, S

    1983-10-01

    This article outlines the geometric principles which underlie the process of making craniofacial measurements in three dimensions by combining information from pairs of coplanar x-ray images. The main focus is upon the rationale of the method rather than upon the computational details. We stress particularly the importance of having available accurate measurements as to the relative positions of the x-ray tubes and the film plane. The use of control arrays of radiopaque "points" whose projected images upon the film plane allow the retrospective calculation of the spatial relationship between the x-ray tubes and the film plane is explained. Finally, the question of correcting for movement of the subject between two films of an image pair is considered briefly.

  8. Feasibility test of Z{sub eff} imaging using x-ray interferometry

    Energy Technology Data Exchange (ETDEWEB)

    Yoneyama, Akio [Central Research Laboratory, Hitachi Ltd., 2520 Akanuma, Hatoyama 350-0395 (Japan); Hyodo, Kazuyuki [High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba 305-0801 (Japan); Takeda, Tohoru [Allied Health Sciences and Graduate School of Medical Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0373 (Japan)

    2013-11-11

    Elemental imaging using X-ray interferometry has been developed. Since the atomic number (Z) of a single-element sample (effective atomic number (Z{sub eff}) for a plural-element sample) corresponds to the ratio of the real to imaginary part of the complex refractive index, an elemental map is calculable with the ratio of an absorption and phase-contrast image. Several metal foils underwent feasibility observations by crystal X-ray interferometry, providing accurate detection of X-ray intensity and phase-shift. The obtained Z{sub eff} image shows that aluminum, iron, nickel, and copper foil were clearly distinguished, and nickel and copper's Z{sub eff} values coincide with ideal Z number within 1%.

  9. Single particle imaging with soft x-rays at the Linac Coherent Light Source

    Science.gov (United States)

    Martin, Andrew V.; Andreasson, Jakob; Aquila, Andrew; Bajt, Saša; Barends, Thomas R. M.; Barthelmess, Miriam; Barty, Anton; Benner, W. Henry; Bostedt, Christoph; Bozek, John D.; Bucksbaum, Phillip; Caleman, Carl; Coppola, Nicola; DePonte, Daniel P.; Ekeberg, Tomas; Epp, Sascha W.; Erk, Benjamin; Farquar, George R.; Fleckenstein, Holger; Foucar, Lutz; Frank, Matthias; Gumprecht, Lars; Hampton, Christina Y.; Hantke, Max; Hartmann, Andreas; Hartmann, Elisabeth; Hartmann, Robert; Hau-Riege, Stephan P.; Hauser, Günther; Holl, Peter; Hoemke, André; Jönsson, Olof; Kassemeyer, Stephan; Kimmel, Nils; Kiskinova, Maya; Krasniqi, Faton; Krzywinski, Jacek; Liang, Mengning; Loh, Ne-Te Duane; Lomb, Lukas; Maia, Filipe R. N. C.; Marchesini, Stefano; Messerschmidt, Marc; Nass, Karol; Odic, Duško; Pedersoli, Emanuele; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schmidt, Carlo; Schultz, Joachim; Seibert, M. Marvin; Shoeman, Robert L.; Sierra, Raymond G.; Soltau, Heike; Starodub, Dmitri; Steinbrener, Jan; Stellato, Francesco; Strüder, Lothar; Svenda, Martin; Tobias, Herbert; Ullrich, Joachim; Weidenspointner, Georg; Westphal, Daniel; White, Thomas A.; Williams, Garth; Hajdu, Janos; Schlichting, Ilme; Bogan, Michael J.; Chapman, Henry N.

    2011-06-01

    Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

  10. Design and image-quality performance of high resolution CMOS-based X-ray imaging detectors for digital mammography

    Science.gov (United States)

    Cha, B. K.; Kim, J. Y.; Kim, Y. J.; Yun, S.; Cho, G.; Kim, H. K.; Seo, C.-W.; Jeon, S.; Huh, Y.

    2012-04-01

    In digital X-ray imaging systems, X-ray imaging detectors based on scintillating screens with electronic devices such as charge-coupled devices (CCDs), thin-film transistors (TFT), complementary metal oxide semiconductor (CMOS) flat panel imagers have been introduced for general radiography, dental, mammography and non-destructive testing (NDT) applications. Recently, a large-area CMOS active-pixel sensor (APS) in combination with scintillation films has been widely used in a variety of digital X-ray imaging applications. We employed a scintillator-based CMOS APS image sensor for high-resolution mammography. In this work, both powder-type Gd2O2S:Tb and a columnar structured CsI:Tl scintillation screens with various thicknesses were fabricated and used as materials to convert X-ray into visible light. These scintillating screens were directly coupled to a CMOS flat panel imager with a 25 × 50 mm2 active area and a 48 μm pixel pitch for high spatial resolution acquisition. We used a W/Al mammographic X-ray source with a 30 kVp energy condition. The imaging characterization of the X-ray detector was measured and analyzed in terms of linearity in incident X-ray dose, modulation transfer function (MTF), noise-power spectrum (NPS) and detective quantum efficiency (DQE).

  11. Procedures for cryogenic X-ray ptychographic imaging of biological samples

    Science.gov (United States)

    Yusuf, M.; Zhang, F.; Chen, B.; Bhartiya, A.; Cunnea, K.; Wagner, U.; Cacho-Nerin, F.; Schwenke, J.; Robinson, I. K.

    2017-01-01

    Biological sample-preparation procedures have been developed for imaging human chromosomes under cryogenic conditions. A new experimental setup, developed for imaging frozen samples using beamline I13 at Diamond Light Source, is described. This manuscript describes the equipment and experimental procedures as well as the authors’ first ptychographic reconstructions using X-rays.

  12. Region-Based 4D Tomographic Image Reconstruction: Application to Cardiac X-ray CT

    NARCIS (Netherlands)

    Eyndhoven, G. Van; Batenburg, K.J.; Sijbers, J.

    2015-01-01

    X-ray computed tomography (CT) is a powerful tool for noninvasive cardiac imaging. However, radiation dose is a major issue. In this paper, we propose an iterative reconstruction method that reduces the radiation dose without compromising image quality. This is achieved by exploiting prior knowledge

  13. Procedures for cryogenic X-ray ptychographic imaging of biological samples.

    Science.gov (United States)

    Yusuf, M; Zhang, F; Chen, B; Bhartiya, A; Cunnea, K; Wagner, U; Cacho-Nerin, F; Schwenke, J; Robinson, I K

    2017-03-01

    Biological sample-preparation procedures have been developed for imaging human chromosomes under cryogenic conditions. A new experimental setup, developed for imaging frozen samples using beamline I13 at Diamond Light Source, is described. This manuscript describes the equipment and experimental procedures as well as the authors' first ptychographic reconstructions using X-rays.

  14. Procedures for cryogenic X-ray ptychographic imaging of biological samples

    Directory of Open Access Journals (Sweden)

    M. Yusuf

    2017-03-01

    Full Text Available Biological sample-preparation procedures have been developed for imaging human chromosomes under cryogenic conditions. A new experimental setup, developed for imaging frozen samples using beamline I13 at Diamond Light Source, is described. This manuscript describes the equipment and experimental procedures as well as the authors' first ptychographic reconstructions using X-rays.

  15. Hard x-ray imaging facility for space shuttle: A scientificq and conceptual engineering study

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, L.E.; Hudson, H.S.; Hurford, G.; Schneible, D.

    1976-11-01

    A shuttle-accommodated instrument for imaging hard X-rays in the study of nonthermal particles and high temperature particles in various solar and cosmic phenomena was defined and its feasibility demonstrated. The imaging system configuration is described as well as the electronics, aspect systems, mechanical and thermal properties and the ground support equipment.

  16. Visible emitting color centers in lithium fluoride for X-ray imaging applications

    Energy Technology Data Exchange (ETDEWEB)

    Bonfigli, F., E-mail: francesca.bonfigli@enea.i [ENEA, C.R. Frascati, V. E. Fermi 45, 00044 Frascati, Rome (Italy); Almaviva, S. [ENEA, C.R. Frascati, V. E. Fermi 45, 00044 Frascati, Rome (Italy); Cedola, A. [Istituto Fotonica e Nanotecnologie, CNR, V. Cineto Romano 42, 00156 Rome (Italy); Franzini, I. [ENEA, C.R. Frascati, V. E. Fermi 45, 00044 Frascati, Rome (Italy); Lagomarsino, S. [Istituto Fotonica e Nanotecnologie, CNR, V. Cineto Romano 42, 00156 Rome (Italy); Pelliccia, D. [Institut fuer Synchrotronstrahlung, ANKA, Forschungszentrum Karlsruhe, Herman-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Montereali, R.M. [ENEA, C.R. Frascati, V. E. Fermi 45, 00044 Frascati, Rome (Italy)

    2010-03-15

    Novel solid-state X-ray imaging detectors have been proposed, tested and they are currently under development for application in photonics, biological investigations and material science, as well as in the characterization of intense X-ray sources. Such as detectors are based on the photoluminescence (PL) of stable color centers (CCs) embedded in lithium fluoride (LiF) crystals and films and their readout process consists of detecting the visible PL of CCs under optical excitation. The improvements of the LiF-based detector sensitivity and response are particularly important in X-ray imaging experiments for reducing the irradiation doses and consequently the sample damage due to the radiation exposure, especially for biological specimens. The characterization of LiF samples colored with 8 keV X-rays from a compact table-top source through photoluminescence spectroscopy and fluorescence microscopy will be presented and discussed in order to investigate the characteristics of these novel X-ray imaging detectors.

  17. Development of X-ray dark-field imaging towards clinical application

    Institute of Scientific and Technical Information of China (English)

    ANDO Masami; RUBENSTEIN Edward; ROBERSON Joseph; SHIMAO Daisuke; SUGIYAMA Hiroshi; TAKEDA Ken; UENO Ei; WADA Hiroshi; HASHIMOTO Eiko; HASHIZUME Hiroyuki; HYODO Kazuyuki; INOUE Hajime; ISHIKAWA Tetsuya; KUNISADA Toshiyuki; MAKSIMENKO Anton; PATTANASIRIWISAWA Wanwisa

    2004-01-01

    Review of X-ray dark-field imaging under development is presented. Its goal is its application to clinical diagnosis of organs that have been invisible by the ordinary techniques. In order to clinically visualize tissues in detail one needs high contrast and high spatial resolution say ~50 μm. This X-ray optics comprises a Bragg asymmetric monochro-collimator and a Bragg case or a Laue case filter with capability of analyzing angle in a parallel position. Their diffraction index is 4,4,0 and the X-ray energy 35 keV (λ= 0.0354 nm). The filter has 0.6 mm thickness in the Bragg case or 1.075 mm or 2.15 mm thickness in the Laue case. Under this condition only the refracted X-rays from object can transmit through the filter while the beam that may receive absorption and/or phase change will not. Soft tissues at human joints thus taken show high contrast images so that the DFI is promising for clinical diagnosis. Preliminary X-ray absorption images of another clinical candidates of ear bones are also shown.

  18. A new streaked soft x-ray imager for the National Ignition Facility.

    Science.gov (United States)

    Benstead, J; Moore, A S; Ahmed, M F; Morton, J; Guymer, T M; Soufli, R; Pardini, T; Hibbard, R L; Bailey, C G; Bell, P M; Hau-Riege, S; Bedzyk, M; Shoup, M J; Reagan, S; Agliata, T; Jungquist, R; Schmidt, D W; Kot, L B; Garbett, W J; Rubery, M S; Skidmore, J W; Gullikson, E; Salmassi, F

    2016-05-01

    A new streaked soft x-ray imager has been designed for use on high energy-density (HED) physics experiments at the National Ignition Facility based at the Lawrence Livermore National Laboratory. This streaked imager uses a slit aperture, single shallow angle reflection from a nickel mirror, and soft x-ray filtering to, when coupled to one of the NIF's x-ray streak cameras, record a 4× magnification, one-dimensional image of an x-ray source with a spatial resolution of less than 90 μm. The energy band pass produced depends upon the filter material used; for the first qualification shots, vanadium and silver-on-titanium filters were used to gate on photon energy ranges of approximately 300-510 eV and 200-400 eV, respectively. A two-channel version of the snout is available for x-ray sources up to 1 mm and a single-channel is available for larger sources up to 3 mm. Both the one and two-channel variants have been qualified on quartz wire and HED physics target shots.

  19. Development of an X-ray imaging system with SOI pixel detectors

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Ryutaro, E-mail: ryunishi@post.kek.jp [School of High Energy Accelerator Science, SOKENDAI (The Graduate University for Advanced Studies), Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Arai, Yasuo; Miyoshi, Toshinobu [Institute of Particle and Nuclear Studies, High Energy Accelerator Research Organization (KEK-IPNS), Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Hirano, Keiichi; Kishimoto, Shunji; Hashimoto, Ryo [Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK-IMSS), Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan)

    2016-09-21

    An X-ray imaging system employing pixel sensors in silicon-on-insulator technology is currently under development. The system consists of an SOI pixel detector (INTPIX4) and a DAQ system based on a multi-purpose readout board (SEABAS2). To correct a bottleneck in the total throughput of the DAQ of the first prototype, parallel processing of the data taking and storing processes and a FIFO buffer were implemented for the new DAQ release. Due to these upgrades, the DAQ throughput was improved from 6 Hz (41 Mbps) to 90 Hz (613 Mbps). The first X-ray imaging system with the new DAQ software release was tested using 33.3 keV and 9.5 keV mono X-rays for three-dimensional computerized tomography. The results of these tests are presented. - Highlights: • The X-ray imaging system employing the SOI pixel sensor is currently under development. • The DAQ of the first prototype has the bottleneck in the total throughput. • The new DAQ release solve the bottleneck by parallel processing and FIFO buffer. • The new DAQ release was tested using 33.3 keV and 9.5 keV mono X-rays.

  20. An investigation of infection control for x-ray cassettes in a diagnostic imaging department

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Matthew [School of Allied Health Professions and Science, Faculty of Health, Wellbeing and Science, University Campus Suffolk, Rope Walk, Ipswich, Suffolk, IP4 1LT (United Kingdom); Harvey, Jane M. [School of Allied Health Professions and Science, Faculty of Health, Wellbeing and Science, University Campus Suffolk, Rope Walk, Ipswich, Suffolk, IP4 1LT (United Kingdom)], E-mail: j.harvey@ucs.ac.uk

    2008-11-15

    Introduction: This research was conducted to investigate if X-ray cassettes could be a possible source of pathogens capable of causing nosocomial infections, and if they could be a possible vector for cross infection within the hospital environment. Method: The research involved the swabbing of X-ray cassettes in a Diagnostic Imaging Department of a large hospital in the east of England. Two areas of the Diagnostic Imaging Department were included in the study. Research concentrated on X-ray cassettes used for mobile radiography, accident and emergency and inpatient use. Forty cassettes were swabbed in total specifically for general levels of bacterial contamination, also for the presence or absence of methicillin-resistant Staphylococcus aureus (MRSA). A mapping exercise was completed following the location of an X-ray cassette typically used in mobile radiography. The exercise noted the level of direct contact with patient's skin and other possible routes of infection. Results: The results demonstrated that there were large levels of growth of samples taken from cassettes and developed in the Microbiology Department. Coagulase-negative Staphylococcus, Micrococci, Diptheroids and species of Bacillus were all identified. The mapping exercise in which the journey of a 35/43 cm cassette used for mobile radiography was tracked found that contact with patient's skin and potential pathogens or routes of cross infection was a common occurrence whilst undertaking mobile radiography. Conclusion: The research has identified the presence of bacterial contamination on cassettes. The research established that X-ray cassettes/imaging plates are often exposed to pathogens and possible routes of cross infection; also that patient's skin often comes directly in contact with the X-ray cassette/imaging plate. The research also shows that as cassettes/imaging plates are a potential source of cross infection, the Diagnostic Imaging Department may be partly responsible

  1. X-ray imaging with a silicon microstrip detector coupled to the RX64 ASIC

    Energy Technology Data Exchange (ETDEWEB)

    Baldazzi, G.; Bollini, D.; Cabal Rodriguez, A.E.; Dabrowski, W.; Diaz Garcia, A.; Gambaccini, M.; Giubellino, P.; Gombia, M.; Grybos, P.; Idzik, M.; Marzari-Chiesa, A.; Montano Zetina, L.M.; Prino, F.; Ramello, L. E-mail: ramello@to.infn.it; Sitta, M.; Swientek, K.; Taibi, A.; Tuffanelli, A.; Wheadon, R.; Wiacek, P

    2003-08-21

    A single photon counting X-ray imaging system, with possible applications to dual energy mammography and angiography, is presented. A silicon microstrip detector with 100 {mu}m pitch strips is coupled to RX64 ASICs, each of them including 64 channels of preamplifier, shaper, discriminator and scaler. The system has low noise, good spatial resolution and high counting rate capability. Results on energy resolution have been obtained with a fluorescence source and quasi-monochromatic X-rays beams. Preliminary images obtained with an angiographic phantom are presented.

  2. Development of the super high angular resolution principle for X-ray imaging *

    Institute of Scientific and Technical Information of China (English)

    Chen Zhang; Shuang-Nan Zhang

    2011-01-01

    Development of the Super High Angular Resolution Principle (SHARP)for coded-mask X-ray imaging is presented. We prove that SHARP can be considered as a generalized coded mask imaging method with a coding pattern comprised of diffraction-interference fringes in the mask pattern. The angular resolution of SHARP can be improved by detecting the fringes more precisely than the mask's element size,i.e. by using a detector with a pixel size smaller than the mask's element size. The proposed mission SHARP-X for solar X-ray observations is also briefly discussed.

  3. Simulation study of phase retrieval for hard X-ray in-line phase contrast imaging

    Institute of Scientific and Technical Information of China (English)

    YU; Bin; PENG; Xiang; TIAN; Jindong; NIU; Hanben; DIAO; Luh

    2005-01-01

    Two algorithms for the phase retrieval of hard X-ray in-line phase contrast imaging are presented. One is referred to as Iterative Angular Spectrum Algorithm (IASA) and the other is a hybrid algorithm that combines IASA with TIE (transport of intensity equation). The calculations of the algorithms are based on free space propagation of the angular spectrum. The new approaches are demonstrated with numerical simulations. Comparisons with other phase retrieval algorithms are also performed. It is shown that the phase retrieval method combining the IASA and TIE is a promising technique for the application of hard X-ray phase contrast imaging.

  4. Very High Resolution Solar X-ray Imaging Using Diffractive Optics

    Science.gov (United States)

    Dennis, B. R.; Skinner, G. K.; Li, M. J.; Shih, A. Y.

    2012-01-01

    This paper describes the development of X-ray diffractive optics for imaging solar flares with better than 0.1 arcsec angular resolution. X-ray images with this resolution of the greater than or equal to 10 MK plasma in solar active regions and solar flares would allow the cross-sectional area of magnetic loops to be resolved and the coronal flare energy release region itself to be probed. The objective of this work is to obtain X-ray images in the iron-line complex at 6.7 keV observed during solar flares with an angular resolution as fine as 0.1 arcsec - over an order of magnitude finer than is now possible. This line emission is from highly ionized iron atoms, primarily Fe xxv, in the hottest flare plasma at temperatures in excess of approximately equal to 10 MK. It provides information on the flare morphology, the iron abundance, and the distribution of the hot plasma. Studying how this plasma is heated to such high temperatures in such short times during solar flares is of critical importance in understanding these powerful transient events, one of the major objectives of solar physics.We describe the design, fabrication, and testing of phase zone plate X-ray lenses with focal lengths of approximately equal to 100 m at these energies that would be capable of achieving these objectives. We show how such lenses could be included on a two-spacecraft formation-flying mission with the lenses on the spacecraft closest to the Sun and an X-ray imaging array on the second spacecraft in the focal plane approximately equal to 100 m away. High resolution X-ray images could be obtained when the two spacecraft are aligned with the region of interest on the Sun. Requirements and constraints for the control of the two spacecraft are discussed together with the overall feasibility of such a formation-flying mission.

  5. Poster — Thur Eve — 24: Commissioning and preliminary measurements using an Attix-style free air ionization chamber for air kerma measurements on the BioMedical Imaging and Therapy beamlines at the Canadian Light Source

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, D [Department of Oncology, University of Alberta, Edmonton, AB (Canada); McEwen, M; Shen, H [Ionizing Radiation Standards, National Research Council of Canada, Ottawa, ON (Canada); Siegbahn, EA [Department of Medical Physics, Stockholm University, Stockholm (Sweden); Fallone, BG; Warkentin, B [Department of Oncology, University of Alberta, Edmonton, AB (Canada); Department of Medical Physics, Cross Cancer Institute, Edmonton, AB (Canada)

    2014-08-15

    Synchrotron facilities, including the Canadian Light Source (CLS), provide opportunities for the development of novel imaging and therapy applications. A vital step progressing these applications toward clinical trials is the availability of accurate dosimetry. In this study, a refurbished Attix-style (cylindrical) free air chamber (FAC) is tested and used for preliminary air kerma measurements on the two BioMedical Imaging and Therapy (BMIT) beamlines at the CLS. The FAC consists of a telescoping chamber that relies on a difference measurement of collected charge in expanded and collapsed configurations. At the National Research Council's X-ray facility, a Victoreen Model 480 FAC was benchmarked against two primary standard FACs. The results indicated an absolute accuracy at the 0.5% level for energies between 60 and 150 kVp. A series of measurements were conducted on the small, non-uniform X-ray beams of the 05B1-1 (∼8 – 100 keV) and 05ID-2 (∼20 – 200 keV) beamlines for a variety of energies, filtrations and beam sizes. For the 05B1-1 beam with 1.1 mm of Cu filtration, recombination corrections of less than 5 % could only be achieved for field sizes no greater than 0.5 mm × 0.6 mm (corresponding to an air kerma rate of ∼ 57 Gy/min). Ionic recombination thus presents a significant challenge to obtaining accurate air kerma rate measurements using this FAC in these high intensity beams. Future work includes measurements using a smaller aperture to sample a smaller and thus more uniform beam area, as well as experimental and Monte Carlo-based investigation of correction factors.

  6. Collagen imaged by Coherent X-ray Diffraction: towards a complementary tool to conventional scanning SAXS

    Energy Technology Data Exchange (ETDEWEB)

    Berenguer de la Cuesta, Felisa; Bean, Richard J; Bozec, Laurent; Robinson, Ian K [London Centre for Nanotechnology (LCN), University College London (UCL), London WC1H 0AH (United Kingdom); McCallion, Catriona; Wallace, Kris [Department of Physics and Astronomy, University College London (UCL), London WC1E 6BT (United Kingdom); Hiller, Jen C; Terrill, Nicholas J, E-mail: f.berenguer@ucl.ac.u [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

    2010-10-01

    Third generation x-ray sources offer unique possibilities for exploiting coherence in the study of materials. New insights in the structure and dynamics of soft condensed matter and biological samples can be obtained by coherent x-ray diffraction (CXD). However, the experimental procedures for applying these methods to collagen tissues are still under development. We present here an investigation for the optimal procedure in order to obtain high quality CXD data from collagen tissues. Sample handling and preparation and adequate coherence defining apertures are among the more relevant factors to take into account. The impact of the results is also discussed, in particular in comparison with the information that can be extracted from conventional scanning small angle x-ray scattering (SAXS). Images of collagen tissues obtained by CXD reconstructions will give additional information about the local structure with higher resolution and will complement scanning SAXS images.

  7. X-ray imaging with photon counting hybrid semiconductor pixel detectors

    CERN Document Server

    Manolopoulos, S; Campbell, M; Snoeys, W; Heijne, Erik H M; Pernigotti, E; Raine, C; Smith, K; Watt, J; O'Shea, V; Ludwig, J; Schwarz, C

    1999-01-01

    Semiconductor pixel detectors, originally developed for particle physics experiments, have been studied as X-ray imaging devices. The performance of devices using the OMEGA 3 read-out chip bump-bonded to pixellated silicon semiconductor detectors is characterised in terms of their signal-to-noise ratio when exposed to 60 kVp X-rays. Although parts of the devices achieve values of this ratio compatible with the noise being photon statistics limited, this is not found to hold for the whole pixel matrix, resulting in the global signal-to-noise ratio being compromised. First results are presented of X-ray images taken with a gallium arsenide pixel detector bump-bonded to a new read-out chip, (MEDIPIX), which is a single photon counting read-out chip incorporating a 15-bit counter in every pixel. (author)

  8. X-ray imaging with photon counting hybrid semiconductor pixel detectors

    Energy Technology Data Exchange (ETDEWEB)

    Manolopoulos, S.; Bates, R.; Campbell, M.; Snoeys, W.; Heijne, E.; Pernigotti, E.; Raine, C.; Smith, K. E-mail: k.smith@physics.gla.ac.uk; Watt, J.; O' Shea, V.; Ludwig, J.; Schwarz, C

    1999-09-11

    Semiconductor pixel detectors, originally developed for particle physics experiments, have been studied as X-ray imaging devices. The performance of devices using the {omega}3 read-out chip bump-bonded to pixellated silicon semiconductor detectors is characterised in terms of their signal-to-noise ratio when exposed to 60 kVp X-rays. Although parts of the devices achieve values of this ratio compatible with the noise being photon statistics limited, this is not found to hold for the whole pixel matrix, resulting in the global signal-to-noise ratio being compromised. First results are presented of X-ray images taken with a gallium arsenide pixel detector bump-bonded to a new read-out chip, (MEDIPIX), which is a single photon counting read-out chip incorporating a 15-bit counter in every pixel. (author)

  9. Fine-pitch glass GEM for high-resolution X-ray imaging

    Science.gov (United States)

    Fujiwara, T.; Mitsuya, Y.; Toyokawa, H.

    2016-12-01

    We have developed a fine-pitch glass gas electron multiplier (G-GEM) for high-resolution X-ray imaging. The fine-pitch G-GEM is made of a 400 μm thick photo-etchable glass substrate with 150 μm pitch holes. It is fabricated using the same wet etching technique as that for the standard G-GEM. In this work, we present the experimental results obtained with a single fine-pitch G-GEM with a 50 × 50 mm2 effective area. We recorded an energy resolution of 16.2% and gas gain up to 5,500 when the detector was irradiated with 5.9 keV X-rays. We present a 50 × 50 mm2 X-ray radiograph image acquired with a scintillation gas and optical readout system.

  10. Infant Hip Joint Diagnostic Support System Based on Clinical Manifestations in X-ray Images

    Directory of Open Access Journals (Sweden)

    Honda,Mitsugi

    2010-06-01

    Full Text Available Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH. The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images:the outward displacement rate, upward displacement rate, OE angle, and alpha angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%.

  11. Three-Dimensional Backscatter X-Ray Imaging System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA application requires a system that can generate 3D images of non-metallic material when access is limited to one side of the material. The objective of this...

  12. A silicon strip detector coupled to the RX64 ASIC for X-ray diagnostic imaging

    Energy Technology Data Exchange (ETDEWEB)

    Baldazzi, G.; Bollini, D.; Cabal Rodriguez, A.E.; Dabrowski, W.; Diaz Garcia, A.; Gambaccini, M.; Giubellino, P.; Gombia, M.; Grybos, P.; Idzik, M.; Marzari-Chiesa, A.; Montano, L.M.; Prino, F. E-mail: prino@to.infn.it; Ramello, L.; Sitta, M.; Swientek, K.; Taibi, A.; Tuffanelli, A.; Wheadon, R.; Wiacek, P

    2003-11-21

    First results from a silicon microstrip detector with 100 {mu}m pitch coupled to the RX64 ASIC are presented. The system is capable of single photon counting in digital X-ray imaging, with possible applications to dual energy mammography and angiography. The main features of the detecting system are low noise, good spatial resolution and high counting rate capability. The energy resolution and the conversion efficiency of the system are discussed, based on results obtained with fluorescence X-ray sources and quasi-monochromatic X-ray beams in the 8-36 keV energy range, with strips being either orthogonal or parallel to the incoming X-rays. We present also preliminary imaging results obtained with a plexiglass phantom with tiny cylindrical cavities filled with iodate solution, simulating patient vessels; in this case the X-ray beam has two components, respectively below and above the iodine K-edge at 33.17 keV.

  13. Demonstration of imaging X-ray Thomson scattering on OMEGA EP

    Science.gov (United States)

    Belancourt, Patrick X.; Theobald, Wolfgang; Keiter, Paul A.; Collins, Tim J. B.; Bonino, Mark J.; Kozlowski, Pawel M.; Regan, Sean P.; Drake, R. Paul

    2016-11-01

    Foams are a common material for high-energy-density physics experiments because of low, tunable densities, and being machinable. Simulating these experiments can be difficult because the equation of state is largely unknown for shocked foams. The focus of this experiment was to develop an x-ray scattering platform for measuring the equation of state of shocked foams on OMEGA EP. The foam used in this experiment is resorcinol formaldehyde with an initial density of 0.34 g/cm3. One long-pulse (10 ns) beam drives a shock into the foam, while the remaining three UV beams with a 2 ns square pulse irradiate a nickel foil to create the x-ray backlighter. The primary diagnostic for this platform, the imaging x-ray Thomson spectrometer, spectrally resolves the scattered x-ray beam while imaging in one spatial dimension. Ray tracing analysis of the density profile gives a compression of 3 ± 1 with a shock speed of 39 ± 6 km/s. Analysis of the scattered x-ray spectra gives an upper bound temperature of 20 eV.

  14. Probabilistic Evaluation of Three-Dimensional Reconstructions from X-Ray Images Spanning a Limited Angle

    Directory of Open Access Journals (Sweden)

    Jörn Ostermann

    2012-12-01

    Full Text Available An important part of computed tomography is the calculation of a three-dimensional reconstruction of an object from series of X-ray images. Unfortunately, some applications do not provide sufficient X-ray images. Then, the reconstructed objects no longer truly represent the original. Inside of the volumes, the accuracy seems to vary unpredictably. In this paper, we introduce a novel method to evaluate any reconstruction, voxel by voxel. The evaluation is based on a sophisticated probabilistic handling of the measured X-rays, as well as the inclusion of a priori knowledge about the materials that the object receiving the X-ray examination consists of. For each voxel, the proposed method outputs a numerical value that represents the probability of existence of a predefined material at the position of the voxel while doing X-ray. Such a probabilistic quality measure was lacking so far. In our experiment, false reconstructed areas get detected by their low probability. In exact reconstructed areas, a high probability predominates. Receiver Operating Characteristics not only confirm the reliability of our quality measure but also demonstrate that existing methods are less suitable for evaluating a reconstruction.

  15. AXSIS: Exploring the frontiers in attosecond X-ray science, imaging and spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kärtner, F.X., E-mail: franz.kaertner@cfel.de [Center for Free-Electron Laser Science, Hamburg (Germany); Institute for Experimental Physics, University of Hamburg, Hamburg (Germany); The Hamburg Center for Ultrafast Imaging, Hamburg (Germany); DESY, Hamburg (Germany); Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA (United States); Ahr, F. [Center for Free-Electron Laser Science, Hamburg (Germany); Institute for Experimental Physics, University of Hamburg, Hamburg (Germany); DESY, Hamburg (Germany); Max Planck Institute for the Structure and Dynamics of Matter, Hamburg (Germany); Calendron, A.-L. [Center for Free-Electron Laser Science, Hamburg (Germany); Institute for Experimental Physics, University of Hamburg, Hamburg (Germany); The Hamburg Center for Ultrafast Imaging, Hamburg (Germany); DESY, Hamburg (Germany); Çankaya, H. [Center for Free-Electron Laser Science, Hamburg (Germany); The Hamburg Center for Ultrafast Imaging, Hamburg (Germany); DESY, Hamburg (Germany); Carbajo, S. [Center for Free-Electron Laser Science, Hamburg (Germany); Institute for Experimental Physics, University of Hamburg, Hamburg (Germany); DESY, Hamburg (Germany); Chang, G.; Cirmi, G. [Center for Free-Electron Laser Science, Hamburg (Germany); The Hamburg Center for Ultrafast Imaging, Hamburg (Germany); DESY, Hamburg (Germany); Dörner, K. [Center for Free-Electron Laser Science, Hamburg (Germany); DESY, Hamburg (Germany); Dorda, U. [DESY, Hamburg (Germany); Fallahi, A. [Center for Free-Electron Laser Science, Hamburg (Germany); DESY, Hamburg (Germany); Hartin, A. [Center for Free-Electron Laser Science, Hamburg (Germany); Institute for Experimental Physics, University of Hamburg, Hamburg (Germany); DESY, Hamburg (Germany); Hemmer, M. [Center for Free-Electron Laser Science, Hamburg (Germany); DESY, Hamburg (Germany); and others

    2016-09-01

    X-ray crystallography is one of the main methods to determine atomic-resolution 3D images of the whole spectrum of molecules ranging from small inorganic clusters to large protein complexes consisting of hundred-thousands of atoms that constitute the macromolecular machinery of life. Life is not static, and unravelling the structure and dynamics of the most important reactions in chemistry and biology is essential to uncover their mechanism. Many of these reactions, including photosynthesis which drives our biosphere, are light induced and occur on ultrafast timescales. These have been studied with high time resolution primarily by optical spectroscopy, enabled by ultrafast laser technology, but they reduce the vast complexity of the process to a few reaction coordinates. In the AXSIS project at CFEL in Hamburg, funded by the European Research Council, we develop the new method of attosecond serial X-ray crystallography and spectroscopy, to give a full description of ultrafast processes atomically resolved in real space and on the electronic energy landscape, from co-measurement of X-ray and optical spectra, and X-ray diffraction. This technique will revolutionize our understanding of structure and function at the atomic and molecular level and thereby unravel fundamental processes in chemistry and biology like energy conversion processes. For that purpose, we develop a compact, fully coherent, THz-driven attosecond X-ray source based on coherent inverse Compton scattering off a free-electron crystal, to outrun radiation damage effects due to the necessary high X-ray irradiance required to acquire diffraction signals. This highly synergistic project starts from a completely clean slate rather than conforming to the specifications of a large free-electron laser (FEL) user facility, to optimize the entire instrumentation towards fundamental measurements of the mechanism of light absorption and excitation energy transfer. A multidisciplinary team formed by laser

  16. X-Ray Scatter Correction on Soft Tissue Images for Portable Cone Beam CT

    Directory of Open Access Journals (Sweden)

    Sorapong Aootaphao

    2016-01-01

    Full Text Available Soft tissue images from portable cone beam computed tomography (CBCT scanners can be used for diagnosis and detection of tumor, cancer, intracerebral hemorrhage, and so forth. Due to large field of view, X-ray scattering which is the main cause of artifacts degrades image quality, such as cupping artifacts, CT number inaccuracy, and low contrast, especially on soft tissue images. In this work, we propose the X-ray scatter correction method for improving soft tissue images. The X-ray scatter correction scheme to estimate X-ray scatter signals is based on the deconvolution technique using the maximum likelihood estimation maximization (MLEM method. The scatter kernels are obtained by simulating the PMMA sheet on the Monte Carlo simulation (MCS software. In the experiment, we used the QRM phantom to quantitatively compare with fan-beam CT (FBCT data in terms of CT number values, contrast to noise ratio, cupping artifacts, and low contrast detectability. Moreover, the PH3 angiography phantom was also used to mimic human soft tissues in the brain. The reconstructed images with our proposed scatter correction show significant improvement on image quality. Thus the proposed scatter correction technique has high potential to detect soft tissues in the brain.

  17. Continuous Shape Estimation of Continuum Robots Using X-ray Images.

    Science.gov (United States)

    Lobaton, Edgar J; Fu, Jinghua; Torres, Luis G; Alterovitz, Ron

    2013-05-06

    We present a new method for continuously and accurately estimating the shape of a continuum robot during a medical procedure using a small number of X-ray projection images (e.g., radiographs or fluoroscopy images). Continuum robots have curvilinear structure, enabling them to maneuver through constrained spaces by bending around obstacles. Accurately estimating the robot's shape continuously over time is crucial for the success of procedures that require avoidance of anatomical obstacles and sensitive tissues. Online shape estimation of a continuum robot is complicated by uncertainty in its kinematic model, movement of the robot during the procedure, noise in X-ray images, and the clinical need to minimize the number of X-ray images acquired. Our new method integrates kinematics models of the robot with data extracted from an optimally selected set of X-ray projection images. Our method represents the shape of the continuum robot over time as a deformable surface which can be described as a linear combination of time and space basis functions. We take advantage of probabilistic priors and numeric optimization to select optimal camera configurations, thus minimizing the expected shape estimation error. We evaluate our method using simulated concentric tube robot procedures and demonstrate that obtaining between 3 and 10 images from viewpoints selected by our method enables online shape estimation with errors significantly lower than using the kinematic model alone or using randomly spaced viewpoints.

  18. Full Field X-Ray Fluorescence Imaging Using Micro Pore Optics for Planetary Surface Exploration

    Science.gov (United States)

    Sarrazin, P.; Blake, D. F.; Gailhanou, M.; Walter, P.; Schyns, E.; Marchis, F.; Thompson, K.; Bristow, T.

    2016-01-01

    Many planetary surface processes leave evidence as small features in the sub-millimetre scale. Current planetary X-ray fluorescence spectrometers lack the spatial resolution to analyse such small features as they only provide global analyses of areas greater than 100 mm(exp 2). A micro-XRF spectrometer will be deployed on the NASA Mars 2020 rover to analyse spots as small as 120m. When using its line-scanning capacity combined to perpendicular scanning by the rover arm, elemental maps can be generated. We present a new instrument that provides full-field XRF imaging, alleviating the need for precise positioning and scanning mechanisms. The Mapping X-ray Fluorescence Spectrometer - "Map-X" - will allow elemental imaging with approximately 100µm spatial resolution and simultaneously provide elemental chemistry at the scale where many relict physical, chemical and biological features can be imaged in ancient rocks. The arm-mounted Map-X instrument is placed directly on the surface of an object and held in a fixed position during measurements. A 25x25 mm(exp 2) surface area is uniformly illuminated with X-rays or alpha-particles and gamma-rays. A novel Micro Pore Optic focusses a fraction of the emitted X-ray fluorescence onto a CCD operated at a few frames per second. On board processing allows measuring the energy and coordinates of each X-ray photon collected. Large sets of frames are reduced into 2d histograms used to compute higher level data products such as elemental maps and XRF spectra from selected regions of interest. XRF spectra are processed on the ground to further determine quantitative elemental compositions. The instrument development will be presented with an emphasis on the characterization and modelling of the X-ray focussing Micro Pore Optic. An outlook on possible alternative XRF imaging applications will be discussed.

  19. Installation of soft X-ray array diagnostics and its application to tomography reconstruction using synthetic KSTAR X-ray images

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Hun; Jang, Juhyeok; Hong, Joohwan; Jang, Siwon; Choe, Wonho, E-mail: wchoe@kaist.ac.kr [Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Impurity and Edge Research Center, Daejeon 305-701 (Korea, Republic of); Pacella, D.; Romano, A.; Gabellieri, L. [Associazione Euratom-ENEA sulla Fusione, C.R. Frascati 00044 (Italy); Kim, Junghee [National Fusion Research Institute, Daejeon 305-806 (Korea, Republic of); Major of Nuclear Fusion and Plasma Science Department, Korea University of Science and Technology, Daejeon 305-350 (Korea, Republic of)

    2014-11-15

    Four-array system of soft X-ray diagnostics was installed on KSTAR tokamak. Each array has 32 viewing chords of two photo-diode array detectors with spatial resolution of 2 cm. To estimate signals from the soft X-ray radiation power, typical n{sub e}, T{sub e}, and argon impurity line radiation profiles in KSTAR are chosen. The photo-diodes were absolutely calibrated as a function of the incident photon energy in 2–40 keV range with a portable X-ray tube. Two-dimensional T{sub e} image properties by multi-energy method were simulated and visualized with six combinations of beryllium filter sets within the dynamic range of signal ratio.

  20. Characterization of x-ray imaging crystal spectrometer for high-resolution spatially-resolved x-ray Thomson scattering measurements in shock-compressed experiments

    Science.gov (United States)

    Lu, J.; Hill, K. W.; Bitter, M.; Pablant, N. A.; Delgado-Aparicio, L. F.; Efthimion, P. C.; Lee, H. J.; Zastrau, U.

    2017-01-01

    We have proposed, designed and built a dual-channel x-ray imaging crystal spectrometer (XICS) for spectrally- and spatially-resolved x-ray Thomson scattering (XRTS) measurements in the Matter in Extreme Conditions (MEC) end station at the Linac Coherent Light Source (LCLS). This spectrometer employs two spherically-bent germanium (Ge) 220 crystals, which are combined to form a large aperture dispersive element with a spectral bandwidth of 300 eV that enables both the elastic and inelastic x-ray scattering peaks to be simultaneously measured. The apparatus and its characterization are described. A resolving power of 1900 was demonstrated and a spatial resolution of 12 μm was achieved in calibration tests. For XRTS measurements, a narrow-bandwidth (ΔE/Ecarbon plasma produced in shock-compressed samples of different forms of carbon. Preliminary results of the scattering experiments from Pyrolytic Graphite samples that illustrate the utility of the instrument are presented.

  1. Three dimensional analysis of coelacanth body structure by computer graphics and X-ray CT images

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Naoki (Jikei Univ., Tokyo (Japan). School of Medicine); Hamada, Takashi

    1990-06-01

    Three dimensional imaging processes were applied for the structural and functional analyses of the modern coelacanth (Latimeria chalumnae). Visualization of the obtained images is performed with computer graphics on the basis of serial images by an X-ray CT scanning method. Reconstruction of three dimensional images of the body structure of coelacanth using the volume rendering and surface rendering methods provides us various information about external and internal shapes of this exquisite fish. (author).

  2. Fast generation of virtual X-ray images for reconstruction of 3D anatomy.

    Science.gov (United States)

    Ehlke, Moritz; Ramm, Heiko; Lamecker, Hans; Hege, Hans-Christian; Zachow, Stefan

    2013-12-01

    We propose a novel GPU-based approach to render virtual X-ray projections of deformable tetrahedral meshes. These meshes represent the shape and the internal density distribution of a particular anatomical structure and are derived from statistical shape and intensity models (SSIMs). We apply our method to improve the geometric reconstruction of 3D anatomy (e.g. pelvic bone) from 2D X-ray images. For that purpose, shape and density of a tetrahedral mesh are varied and virtual X-ray projections are generated within an optimization process until the similarity between the computed virtual X-ray and the respective anatomy depicted in a given clinical X-ray is maximized. The OpenGL implementation presented in this work deforms and projects tetrahedral meshes of high resolution (200.000+ tetrahedra) at interactive rates. It generates virtual X-rays that accurately depict the density distribution of an anatomy of interest. Compared to existing methods that accumulate X-ray attenuation in deformable meshes, our novel approach significantly boosts the deformation/projection performance. The proposed projection algorithm scales better with respect to mesh resolution and complexity of the density distribution, and the combined deformation and projection on the GPU scales better with respect to the number of deformation parameters. The gain in performance allows for a larger number of cycles in the optimization process. Consequently, it reduces the risk of being stuck in a local optimum. We believe that our approach will improve treatments in orthopedics, where 3D anatomical information is essential.

  3. X-Ray Phase Imaging for Breast Cancer Detection

    Science.gov (United States)

    2012-09-01

    cross sections,” Journal of Physical Chemistry Reference Data 4, 471–538 (1975); 32. L. Rudin , “Images, numerical analysis of singularities and shock...filters,” Report #TR:5250:87, Caltech, C,S, Dept. (1987). 33. L. I. Rudin , S. Osher, and E. Fatemi, “Nonlinear total variation based noise removal...the authors suggest a measure which can be employed as an appropriate image accuracy measure, which was first investigated by Rudin in [32]. 2.2. An

  4. Luminescence imaging of water during irradiation of X-ray photons lower energy than Cerenkov- light threshold

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi; Koyama, Shuji; Komori, Masataka [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine (Japan); Toshito, Toshiyuki [Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center (Japan)

    2016-10-01

    Luminescence imaging of water using X-ray photon irradiation at energy lower than maximum energy of ~200 keV is thought to be impossible because the secondary electrons produced in this energy range do not emit Cerenkov- light. Contrary to this consensus assumption, we show that the luminescence imaging of water can be achieved by X-ray irradiation at energy lower than 120 keV. We placed water phantoms on a table with a conventional X-ray imaging system, and luminescence images of these phantoms were measured with a high-sensitivity, cooled charge coupled device (CCD) camera during X-ray photon irradiation at energy below 120 keV. We also carried out such imaging of an acrylic block and plastic scintillator. The luminescence images of water phantoms taken during X-ray photon irradiation clearly showed X-ray photon distribution. The intensity of the X-ray photon images of the phantom increased almost proportionally to the number of X-ray irradiations. Lower-energy X-ray photon irradiation showed lower-intensity luminescence at the deeper parts of the phantom due to the higher X-ray absorption in the water phantom. Furthermore, lower-intensity luminescence also appeared at the deeper parts of the acrylic phantom due to its higher density than water. The intensity of the luminescence for water was 0.005% of that for plastic scintillator. Luminescence imaging of water during X-ray photon irradiation at energy lower than 120 keV was possible. This luminescence imaging method is promising for dose estimation in X-ray imaging systems.

  5. BodyPart Detection in X-Ray Images

    NARCIS (Netherlands)

    Jeanne, V.; Unay, D.

    2008-01-01

    Medical Image Classification& Retrieval is nowadays a hot topic. Many projects already exist in this field, like the IRMA project, but the obtained results are not yet good enough for real implementation. The goal of this report is to investigate in features that could enable a good performance fo

  6. Dynamic measures of regional lung air volume using phase contrast x-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kitchen, M J; Lewis, R A; Morgan, M J; Siu, K K W; Habib, A [School of Physics, Monash University, Melbourne VIC 3800 (Australia); Wallace, M J; Siew, M L; Hooper, S B [Department of Physiology, Monash University, Melbourne VIC 3800 (Australia); Fouras, A [Division of Biological Engineering, Monash University, Melbourne VIC 3800 (Australia); Yagi, N; Uesugi, K [SPring-8/JASRI, Sayo, Hyogo 679-5198 (Japan)], E-mail: Marcus.Kitchen@sci.monash.edu.au

    2008-11-07

    Phase contrast x-ray imaging can provide detailed images of lung morphology with sufficient spatial resolution to observe the terminal airways (alveoli). We demonstrate that quantitative functional and anatomical imaging of lung ventilation can be achieved in vivo using two-dimensional phase contrast x-ray images with high contrast and spatial resolution (<100 {mu}m) in near real time. Changes in lung air volume as small as 25 {mu}L were calculated from the images of term and preterm rabbit pup lungs (n = 28) using a single-image phase retrieval algorithm. Comparisons with plethysmography and computed tomography showed that the technique provided an accurate and robust method of measuring total lung air volumes. Furthermore, regional ventilation was measured by partitioning the phase contrast images, which revealed differences in aeration for different ventilation strategies.

  7. High-Resolution X-Ray Lensless Imaging by Differential Holographic Encoding

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Diling [Stanford Univ., CA (United States). Dept. of Applied Physics; SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Inst. for Material and Energy Science; Guizar-Sicairos, Manuel [Univ. of Rochester, NY (United States). Inst. of Optics; Wu, Benny [Stanford Univ., CA (United States). Dept. of Applied Physics; SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Inst. for Material and Energy Science; Scherz, Andreas [SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Inst. for Material and Energy Science; Acremann, Yves [SLAC National Accelerator Lab., Menlo Park, CA (United States). Photon Ultrafast Laser Science and Engineering Inst. (PULSE); Tyliszczak, Tolek [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS); Fischer, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Center for X-ray Optics; Friedenberger, Nina [Universitat Duisburg-Essen (Germany). Dept. of Physics and Center for Nanointegration Duisburg-Essen (CeNIDE); Ollefs, Katharina [Universitat Duisburg-Essen (Germany). Dept. of Physics and Center for Nanointegration Duisburg-Essen (CeNIDE); Farle, Michael [Universitat Duisburg-Essen (Germany). Dept. of Physics and Center for Nanointegration Duisburg-Essen (CeNIDE); Fienup, James R. [Univ. of Rochester, NY (United States). Inst. of Optics; Stöhr, Joachim [SLAC National Accelerator Lab., Menlo Park, CA (United States). Linac Coherent Light Source (LCLS)

    2010-07-01

    X-ray free electron lasers (X-FELs) will soon offer femtosecond pulses of laterally coherent x-rays with sufficient intensity to record single-shot coherent scattering patterns for nanoscale imaging. Pulse trains created by split and- delay techniques even open the door for cinematography on unprecedented nanometer length and femtosecond time scales. A key to real space ultrafast motion pictures is fast and reliable inversion of the recorded reciprocal space scattering patterns. Here we for the first time demonstrate in the x-ray regime the power of a novel technique for lensless high resolution imaging, previously suggested by Guizar-Sicairos and Fienup termed holography with extended reference by autocorrelation linear differential operation, HERALD0. We have achieved superior resolution over conventional x-ray Fourier transform holography (FTH) without sacrifices in SNR or significant increase in algorithmic complexity. By combining images obtained from individual sharp features on an extended reference, we further show that the resolution can be even extended beyond the reference fabrication limits. Direct comparison to iterative phase retrieval image reconstruction and images recorded with state of-the-art zone plate microscopes is presented. Our results demonstrate the power of HERALDO as a favorable candidate for robust inversion of single-shot coherent scattering patterns.

  8. High resolution x-ray lensless imaging by differential holographic encoding

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, D.; Guizar-Sicairos, M.; Wu, B.; Scherz, A.; Acremann, Y.; Tylisczcak, T.; Fischer, P.; Friedenberger, N.; Ollefs, K.; Farle, M.; Fienup, J. R.; Stohr, J.

    2009-11-02

    X-ray free electron lasers (X-FEL{sub s}) will soon offer femtosecond pulses of laterally coherent x-rays with sufficient intensity to record single-shot coherent scattering patterns for nanoscale imaging. Pulse trains created by splitand-delay techniques even open the door for cinematography on unprecedented nanometer length and femtosecond time scales. A key to real space ultrafast motion pictures is fast and reliable inversion of the recorded reciprocal space scattering patterns. Here we for the first time demonstrate in the x-ray regime the power of a novel technique for lensless high resolution imaging, previously suggested by Guizar-Sicairos and Fienup termed holography with extended reference by autocorrelation linear differential operation, HERALD0. We have achieved superior resolution over conventional x-ray Fourier transform holography (FTH) without sacrifices in SNR or significant increase in algorithmic complexity. By combining images obtained from individual sharp features on an extended reference, we further show that the resolution can be even extended beyond the reference fabrication limits. Direct comparison to iterative phase retrieval image reconstruction and images recorded with stateof- the-art zone plate microscopes is presented. Our results demonstrate the power of HERALDO as a favorable candidate for robust inversion of single-shot coherent scattering patterns.

  9. Microfocus X-ray imaging of Brazil nuts for quality control

    Energy Technology Data Exchange (ETDEWEB)

    Franco, Margareth Kazuyo Kobayashi Dias, E-mail: mkfranco@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Yokaichiya, Fabiano, E-mail: fabiano.yokaichiya@helmholtz-berlin.de [Department Quantum Phenomena in Novel Materials, Helmholtz Zentrum Berlim für Materialien und Energie GmbH, Berlin (Germany); Kardjilov, Nikolay, E-mail: kardjilov@helmholtz-berlim.de [Institut Angewandte Materialforschung, Helmholtz Zentrum Berlim für Materialien und Energie GmbH, Berlin (Germany); Ferraz, Antonio Carlos de Oliveira, E-mail: carlos@feagri.unicamp.br [Universidade Estadual de Campinas (FEAGRI/UNICAMP), SP (Brazil). Faculdade de Engenharia Agricola

    2015-07-15

    Non-destructive quality assessment of food prior to processing is desirable in commercial facilities due to its non-invasive nature, for economic reasons and for its safety appeals. Grading Brazil nuts in this way allows for the separation of undesirable nuts to avoid contamination during the automatic nut shelling process. The aim of this study was to evaluate the feasibility of X-ray phase contrast enhanced imaging in assessing nut quality. For this goal, details of the imaging technique are described and phase contrast X-ray and microtomography imaging of nut samples are investigated. Both high quality (i.e. 'sound' nuts as well as treated nuts were examined. It was concluded that both the X-ray imaging and tomography techniques have the potential to discriminate morphological features of the nut and to identify 'sound' kernels from atypical ones. Larger nuts and nuts with a larger gap area between shell and kernel were concluded to have more atypical formations. Both techniques also seemed promising for use in automatic sorting lines. However, by using microtomography, the visualization of finer formations not noticeable in the X-ray images was possible. Further studies shall be carried out to investigate the nature of these formations, how they affect nut quality and their evolution with storage time. (author)

  10. Hard X-ray spectroscopic nano-imaging of hierarchical functional materials at work.

    Science.gov (United States)

    Andrews, Joy C; Weckhuysen, Bert M

    2013-11-11

    Heterogeneous catalysts often consist of an active metal (oxide) in close contact with a support material and various promoter elements. Although macroscopic properties, such as activity, selectivity and stability, can be assessed with catalyst performance testing, the development of relevant, preferably quantitative structure-performance relationships require the use of advanced characterisation methods. Spectroscopic imaging in the hard X-ray region with nanometer-scale resolution has very recently emerged as a powerful approach to elucidate the hierarchical structure and related chemistry of catalytic solids in action under realistic reaction conditions. This X-ray-based chemical imaging method benefits from the combination of high resolution (∼30 nm) with large X-ray penetration and depth of focus, and the possibility for probing large areas with mosaic imaging. These capabilities make it possible to obtain spatial and temporal information on chemical changes in catalytic solids as well as a wide variety of other functional materials, such as fuel cells and batteries, in their full complexity and integrity. In this concept article we provide details on the method and setup of full-field hard X-ray spectroscopic imaging, illustrate its potential for spatiotemporal chemical imaging by making use of recent showcases, outline the pros and cons of this experimental approach and discuss some future directions for hierarchical functional materials research.

  11. Feasibility study of on-line digital X-ray imaging for irradiated fuel rods

    Energy Technology Data Exchange (ETDEWEB)

    Parthoens, Y.; Gys, A. [Reactor Material Research Department, SCK-CEN, Mol (Belgium); Smolders, V. [Industrial Engineer Department, Katholieke Hogeschool Kempen, Geel (Belgium)

    2003-07-01

    At the Reactor Material Research Department of the Belgian Nuclear Research Centre SCK-CEN Xray imaging of the internal parts of irradiated fuel rods is done on silver-halide films using a 420 kV X-ray source. The replacement of the films by an on-line digital X-ray imaging system implies several advantages. Images can be evaluated instantly and source parameters can be optimized more easily. Time consuming film development is superfluous. The images can digitally be enhanced, processed, reported and archived. Within this work the feasibility of four commercial on-line digital X-ray imaging systems were studied for post-irradiation examination on fuel rods in a hot cell environment. The criteria to evaluate the systems were image quality, integration in the existing hot cell infrastructure, durability and cost price. For the evaluation and comparison of the image quality a simulation fuel rod was fabricated. Three systems suffered from lack of sensitivity, contrast and/or resolution. Only the CsI-scintillator coupled to a CCD-camera with image intensifier gave a sufficient image quality. On the other hand the image intensifiers' dimensions are difficult to integrate in the existing hot cell infrastructure. Also the durability of intensifier screens is questionable as they are susceptible to image burn. Smaller image intensifiers easier to integrate are commercial available nowadays.

  12. X-ray imaging of spin currents and magnetisation dynamics at the nanoscale

    Science.gov (United States)

    Bonetti, Stefano

    2017-04-01

    Understanding how spins move in time and space is the aim of both fundamental and applied research in modern magnetism. Over the past three decades, research in this field has led to technological advances that have had a major impact on our society, while improving the understanding of the fundamentals of spin physics. However, important questions still remain unanswered, because it is experimentally challenging to directly observe spins and their motion with a combined high spatial and temporal resolution. In this article, we present an overview of the recent advances in x-ray microscopy that allow researchers to directly watch spins move in time and space at the microscopically relevant scales. We discuss scanning x-ray transmission microscopy (STXM) at resonant soft x-ray edges, which is available at most modern synchrotron light sources. This technique measures magnetic contrast through the x-ray magnetic circular dichroism (XMCD) effect at the resonant absorption edges, while focusing the x-ray radiation at the nanometre scale, and using the intrinsic pulsed structure of synchrotron-generated x-rays to create time-resolved images of magnetism at the nanoscale. In particular, we discuss how the presence of spin currents can be detected by imaging spin accumulation, and how the magnetisation dynamics in thin ferromagnetic films can be directly imaged. We discuss how a direct look at the phenomena allows for a deeper understanding of the the physics at play, that is not accessible to other, more indirect techniques. Finally, we present an overview of the exciting opportunities that lie ahead to further understand the fundamentals of novel spin physics, opportunities offered by the appearance of diffraction limited storage rings and free electron lasers.

  13. X-ray Birefringence Imaging of Materials with Anisotropic Molecular Dynamics.

    Science.gov (United States)

    Palmer, Benjamin A; Edwards-Gau, Gregory R; Kariuki, Benson M; Harris, Kenneth D M; Dolbnya, Igor P; Collins, Stephen P; Sutter, John P

    2015-02-05

    The X-ray birefringence imaging (XBI) technique, reported very recently, is a sensitive tool for spatially resolved mapping of the local orientational properties of anisotropic materials. In this paper, we report the first XBI measurements on materials that undergo anisotropic molecular dynamics. Using incident linearly polarized X-rays with energy close to the Br K-edge, the X-ray birefringence is dictated by the orientational properties of the C-Br bonds in the material. We focus on two materials (urea inclusion compounds containing 1,8-dibromooctane and 1,10-dibromodecane guest molecules) for which the reorientational dynamics of the brominated guest molecules (and hence the reorientational dynamics of the C-Br bonds) are already well characterized by other experimental techniques. The XBI results demonstrate clearly that, for the anisotropic molecular dynamics in these materials, the effective X-ray optic axis for the X-ray birefringence phenomenon is the time-averaged resultant of the orientational distribution of the C-Br bonds.

  14. Rest-wavelength Fiducials for the ITER Core Imaging X-ray Spectrometer

    Science.gov (United States)

    Beiersdorfer, P.; Brown, G. V.; Graf, A. T.; Bitter, M.; Hill, K. W.; Kelley, R. L.; Kilbourne, C. A.; Leutenegger, M. A.; Porter, F. S.

    2012-01-01

    Absolute wavelength references are needed to derive the plasma velocities from the Doppler shift of a given line emitted by a moving plasma. We show that such reference standards exist for the strongest x-ray line in neonlike W64+, which has become the line of choice for the ITER (Latin the way) core imaging x-ray spectrometer. Close-by standards are the Hf L3 line and the Ir L2 line, which bracket the W64+ line by 30 eV; other standards are given by the Ir L1 and L2 lines and the Hf L1 and L2 lines, which bracket the W64+ line by 40 and 160 eV, respectively. The reference standards can be produced by an x-ray tube built into the ITER spectrometer. We present spectra of the reference lines obtained with an x-ray microcalorimeter and compare them to spectra of the W64+ line obtained both with an x-ray microcalorimeter and a crystal spectrometer

  15. Rest-wavelength fiducials for the ITER core imaging x-ray spectrometer.

    Science.gov (United States)

    Beiersdorfer, P; Brown, G V; Graf, A T; Bitter, M; Hill, K W; Kelley, R L; Kilbourne, C A; Leutenegger, M A; Porter, F S

    2012-10-01

    Absolute wavelength references are needed to derive the plasma velocities from the Doppler shift of a given line emitted by a moving plasma. We show that such reference standards exist for the strongest x-ray line in neonlike W(64+), which has become the line of choice for the ITER (Latin "the way") core imaging x-ray spectrometer. Close-by standards are the Hf Lβ(3) line and the Ir Lα(2) line, which bracket the W(64+) line by ±30 eV; other standards are given by the Ir Lα(1) and Lα(2) lines and the Hf Lβ(1) and Lβ(2) lines, which bracket the W(64+) line by ±40 and ±160 eV, respectively. The reference standards can be produced by an x-ray tube built into the ITER spectrometer. We present spectra of the reference lines obtained with an x-ray microcalorimeter and compare them to spectra of the W(64+) line obtained both with an x-ray microcalorimeter and a crystal spectrometer.

  16. CIX - A Detector for Spectral Enhanced X-ray Imaging by Simultaneous Counting and Integrating

    CERN Document Server

    Krüger, H; Kraft, E; Wermes, N; Fischer, P; Peric, I; Herrmann, C; Overdick, M; Rütten, W

    2008-01-01

    A hybrid pixel detector based on the concept of simultaneous charge integration and photon counting will be presented. The second generation of a counting and integrating X-ray prototype CMOS chip (CIX) has been operated with different direct converting sensor materials (CdZnTe and CdTe) bump bonded to its 8x8 pixel matrix. Photon counting devices give excellent results for low to medium X-ray fluxes but saturate at high rates while charge integration allows the detection of very high fluxes but is limited at low rates by the finite signal to noise ratio. The combination of both signal processing concepts therefore extends the resolvable dynamic range of the X-ray detector. In addition, for a large region of the dynamic range, where counter and integrator operate simultaneously, the mean energy of the detected X-ray spectrum can be calculated. This spectral information can be used to enhance the contrast of the X-ray image. The advantages of the counting and integrating signal processing concept and the perfo...

  17. An X-ray imaging device based on a GEM detector with delay-line readout

    Science.gov (United States)

    Zhou, Yi; Li, Cheng; Sun, Yong-Jie; Shao, Ming

    2010-01-01

    An X-ray imaging device based on a triple-GEM (Gas Electron Multiplier) detector, a fast delay-line circuit with 700 MHz cut-off frequency and two dimensional readout strips with 150 μm width on the top and 250 μm width on the bottom, is designed and tested. The localization information is derived from the propagation time of the induced signals on the readout strips. This device has a good spatial resolution of 150 μm and works stably at an intensity of 105 Hz/mm2 with 8 keV X-rays.

  18. Phase Sensitive X-Ray Diffraction Imaging of Defects in Biological Macromolecular Crystals

    Science.gov (United States)

    Hu, Z. W.; Lai, B.; Chu, Y. S.; Cai, Z.; Mancini, D. C.; Thomas, B. R.; Chernov, A. A.; Curreri, Peter A. (Technical Monitor)

    2002-01-01

    Characterization of defects and/or disorder in biological macromolecular crystals presents much greater challenges than in conventional small-molecule crystals. The lack of sufficient contrast of defects is often a limiting factor in x-ray diffraction topography of protein crystals. This has seriously hampered efforts to understand mechanisms and origins of formation of imperfections, and the role of defects as essential entities in the bulk of macromolecular crystals. In this report, we employ a phase sensitive x-ray diffraction imaging approach for augmenting the contrast of defects in protein crystals.

  19. Ultrafast Coherent Diffraction Imaging with X-ray Free-Electron Lasers

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, H N; Bajt, S; Barty, A; Benner, W; Bogan, M; Frank, M; Hau-Riege, S; London, R; Marchesini, S; Spiller, E; Szoke, A; Woods, B; Boutet, S; Hodgson, K; Hajdu, J; Bergh, M; Burmeister, F; Caleman, C; Huldt, G; Maia, F; Seibert, M M; der Spoel, D v

    2006-08-22

    The ultrafast pulses from X-ray free-electron lasers will enable imaging of non-periodic objects at near-atomic resolution [1, Neutze]. These objects could include single molecules, protein complexes, or virus particles. The specimen would be completely destroyed by the pulse in a Coulomb explosion, but that destruction will only happen after the pulse. The scattering from the sample will give structural information about the undamaged object. There are many technical challenges that must be addressed before carrying out such experiments at an XFEL, which we are doing so with experiments at FLASH, the soft-X-ray FEL at DESY.

  20. Toward atomic resolution diffractive imaging of isolated molecules with x-ray free-electron lasers

    CERN Document Server

    Stern, Stephan; Filsinger, Frank; Rouzée, Arnaud; Rudenko, Artem; Johnsson, Per; Martin, Andrew V; Barty, Anton; Bostedt, Christoph; Bozek, John D; Coffee, Ryan N; Epp, Sascha; Erk, Benjamin; Foucar, Lutz; Hartmann, Robert; Kimmel, Nils; Kühnel, Kai-Uwe; Maurer, Jochen; Messerschmidt, Marc; Rudek, Benedikt; Starodub, Dmitri G; Thøgersen, Jan; Weidenspointner, Georg; White, Thomas A; Stapelfeldt, Henrik; Rolles, Daniel; Chapman, Henry N; Küpper, Jochen

    2014-01-01

    We give a detailed account of the theoretical analysis and the experimental results of an x-ray-diffraction experiment on quantum-state selected and strongly laser-aligned gas-phase ensembles of the prototypical large asymmetric rotor molecule 2,5-diiodobenzonitrile, performed at the Linac Coherent Light Source [Phys. Rev. Lett. 112, 083002 (2014)]. This experiment is the first step toward coherent diffractive imaging of structures and structural dynamics of isolated molecules at atomic resolution, i. e., picometers and femtoseconds, using x-ray free-electron lasers.

  1. Tracking the density evolution in counter-propagating shock waves using imaging X-ray scattering

    Science.gov (United States)

    Zastrau, U.; Gamboa, E. J.; Kraus, D.; Benage, J. F.; Drake, R. P.; Efthimion, P.; Falk, K.; Falcone, R. W.; Fletcher, L. B.; Galtier, E.; Gauthier, M.; Granados, E.; Hastings, J. B.; Heimann, P.; Hill, K.; Keiter, P. A.; Lu, J.; MacDonald, M. J.; Montgomery, D. S.; Nagler, B.; Pablant, N.; Schropp, A.; Tobias, B.; Gericke, D. O.; Glenzer, S. H.; Lee, H. J.

    2016-07-01

    We present results from time-resolved X-ray imaging and inelastic scattering on collective excitations. These data are then employed to infer the mass density evolution within laser-driven shock waves. In our experiments, thin carbon foils are first strongly compressed and then driven into a dense state by counter-propagating shock waves. The different measurements agree that the graphite sample is about twofold compressed when the shock waves collide, and a sharp increase in forward scattering indicates disassembly of the sample 1 ns thereafter. We can benchmark hydrodynamics simulations of colliding shock waves by the X-ray scattering methods employed.

  2. Near-field speckle-scanning-based x-ray imaging

    OpenAIRE

    Berujon, Sebastien; Ziegler, Eric

    2015-01-01

    The x-ray near-field speckle-scanning concept is an approach recently introduced to obtain absorption, phase, and dark-field images of a sample. In this paper, we present ways of recovering from a sample its ultrasmall-angle x-ray scattering distribution using numerical deconvolution. We also show how to access the 2D phase gradient signal from random step scans, the latter having the potential to elude the flat-field correction error. Each feature is explained theoretically and demonstrated ...

  3. X-ray dark-field imaging for detection of foreign bodies in food

    DEFF Research Database (Denmark)

    Nielsen, Mikkel Schou; Lauridsen, Torsten; Feidenhans'l, Robert Krarup;

    2013-01-01

    Conventional X-ray transmission radiography has long been used for online detection of foreign bodies in food products relying on the absorption contrast between the foreign body and food product. In this paper, we present a novel approach for detection of organic foreign bodies such as paper...... and insects in two food products using X-ray dark-field imaging with a grating interferometer. The ability to detect the foreign bodies is quantified using a measure of the contrast-to-noise ratio. © 2012 Elsevier Ltd....

  4. Note: Gratings on low absorbing substrates for x-ray phase contrast imaging

    Science.gov (United States)

    Koch, F. J.; Schröter, T. J.; Kunka, D.; Meyer, P.; Meiser, J.; Faisal, A.; Khalil, M. I.; Birnbacher, L.; Viermetz, M.; Walter, M.; Schulz, J.; Pfeiffer, F.; Mohr, J.

    2015-12-01

    Grating based X-ray phase contrast imaging is on the verge of being applied in clinical settings. To achieve this goal, compact setups with high sensitivity and dose efficiency are necessary. Both can be increased by eliminating unwanted absorption in the beam path, which is mainly due to the grating substrates. Fabrication of gratings via deep X-ray lithography can address this issue by replacing the commonly used silicon substrate with materials with lower X-ray absorption that fulfill certain boundary conditions. Gratings were produced on both graphite and polymer substrates without compromising on structure quality. These gratings were tested in a three-grating setup with a source operated at 40 kVp and lead to an increase in the detector photon count rate of almost a factor of 4 compared to a set of gratings on silicon substrates. As the visibility was hardly affected, this corresponds to a significant increase in sensitivity and therefore dose efficiency.

  5. Image-based characterization of microfocus x-ray target failure

    Science.gov (United States)

    Robinson, Vance S.; Raber, Thomas; Ross, William R.

    2016-09-01

    X-ray targets in microfocus x-ray tubes fail primarily due to sublimation and evaporation of tungsten while exposed to the electron beam. The temperature at the point of impact of the electron beam depends on the beam energy (200-300 kV), the beam current (<10 mA), the cross section (<1 mm) and the intensity profile. In order to preserve the target for a reasonable lifetime, temperatures at the spot do not typically exceed 2500 C. As tungsten evaporates from the surface of the target, the surface starts to pit and this can affect the x-ray production in multiple ways: the photon flux decreases, the heel effect is enhanced, the effective spot size changes shape and/or size. Indirectly, the target damage incurred over time or due to intense use will undermine the image quality by reducing image contrast, changing the resolution or degrading the signal to noise ratio. A detailed description of how x-ray target damage is incurred and the potential impact on image quality is reviewed in detail. Experimental results showing the target damage and associated loss of image quality are discussed.

  6. A multiplexed high-resolution imaging spectrometer for resonant inelastic soft X-ray scattering spectroscopy.

    Science.gov (United States)

    Warwick, Tony; Chuang, Yi De; Voronov, Dmitriy L; Padmore, Howard A

    2014-07-01

    The optical design of a two-dimensional imaging soft X-ray spectrometer is described. A monochromator will produce a dispersed spectrum in a narrow vertical illuminated stripe (∼2 µm wide by ∼2 mm tall) on a sample. The spectrometer will use inelastically scattered X-rays to image the extended field on the sample in the incident photon energy direction (vertical), resolving the incident photon energy. At the same time it will image and disperse the scattered photons in the orthogonal (horizontal) direction, resolving the scattered photon energy. The principal challenge is to design a system that images from the flat-field illumination of the sample to the flat field of the detector and to achieve sufficiently high spectral resolution. This spectrometer provides a completely parallel resonant inelastic X-ray scattering measurement at high spectral resolution (∼30,000) over the energy bandwidth (∼5 eV) of a soft X-ray absorption resonance.

  7. Single-grain Silicon Technology for Large Area X-ray Imaging

    NARCIS (Netherlands)

    Arslan, A.

    2015-01-01

    Digital flat panel X-ray imagers are currently using a-Si and poly-Si thin-film-transistors (TFTs). a-Si TFT permits the use of large area substrates, however, due to the amorphous nature, the carrier mobility is very low (<1 cm2/Vs). Poly-Si TFT improves the mobility (~150 cm2/Vs) but due to random

  8. Hohlraum Target Alignment from X-ray Detector Images using Starburst Design Patterns

    Energy Technology Data Exchange (ETDEWEB)

    Leach, R R; Conder, A; Edwards, O; Kroll, J; Kozioziemski, B; Mapoles, E; McGuigan, D; Wilhelmsen, K

    2010-12-14

    National Ignition Facility (NIF) is a high-energy laser facility comprised of 192 laser beams focused with enough power and precision on a hydrogen-filled spherical, cryogenic target to initiate a fusion reaction. The target container, or hohlraum, must be accurately aligned to an x-ray imaging system to allow careful monitoring of the frozen fuel layer in the target. To achieve alignment, x-ray images are acquired through starburst-shaped windows cut into opposite sides of the hohlraum. When the hohlraum is in alignment, the starburst pattern pairs match nearly exactly and allow a clear view of the ice layer formation on the edge of the target capsule. During the alignment process, x-ray image analysis is applied to determine the direction and magnitude of adjustment required. X-ray detector and source are moved in concert during the alignment process. The automated pointing alignment system described here is both accurate and efficient. In this paper, we describe the control and associated image processing that enables automation of the starburst pointing alignment.

  9. Geometrical Calibration of X-Ray Imaging With RGB Cameras for 3D Reconstruction.

    Science.gov (United States)

    Albiol, Francisco; Corbi, Alberto; Albiol, Alberto

    2016-08-01

    We present a methodology to recover the geometrical calibration of conventional X-ray settings with the help of an ordinary video camera and visible fiducials that are present in the scene. After calibration, equivalent points of interest can be easily identifiable with the help of the epipolar geometry. The same procedure also allows the measurement of real anatomic lengths and angles and obtains accurate 3D locations from image points. Our approach completely eliminates the need for X-ray-opaque reference marks (and necessary supporting frames) which can sometimes be invasive for the patient, occlude the radiographic picture, and end up projected outside the imaging sensor area in oblique protocols. Two possible frameworks are envisioned: a spatially shifting X-ray anode around the patient/object and a moving patient that moves/rotates while the imaging system remains fixed. As a proof of concept, experiences with a device under test (DUT), an anthropomorphic phantom and a real brachytherapy session have been carried out. The results show that it is possible to identify common points with a proper level of accuracy and retrieve three-dimensional locations, lengths and shapes with a millimetric level of precision. The presented approach is simple and compatible with both current and legacy widespread diagnostic X-ray imaging deployments and it can represent a good and inexpensive alternative to other radiological modalities like CT.

  10. Spinal curvature determination from an X-ray image using a deformable model

    NARCIS (Netherlands)

    Sardjono, T.A.; Wilkinson, M.H.F.; Ooijen, P.M.A. van; Veldhuizen, A.G.; Purnama, K.E.; Verkerke, G.J.; Ibrahim, F; Osman, NAA; Usman, J; Kadri, NA

    2007-01-01

    This paper presents a spinal curvature determination from frontal X-ray images of scoliotic patients. A new deformable model, Modified CPM (Charged Particles Model), has been developed and used to determine the spinal curvature. The Modified CPM is a new approach of a deformable model based on CPM,

  11. 3D Prior Image Constrained Projection Completion for X-ray CT Metal Artifact Reduction

    NARCIS (Netherlands)

    Mehranian, Abolfazl; Ay, Mohammad Reza; Rahmim, Arman; Zaidi, Habib

    2013-01-01

    The presence of metallic implants in the body of patients undergoing X-ray computed tomography (CT) examinations often results insevere streaking artifacts that degrade image quality. In this work, we propose a new metal artifact reduction (MAR) algorithm for 2D fan-beam and 3D cone-beam CT based on

  12. High spatial resolution X-ray and gamma ray imaging system using diffraction crystals

    Science.gov (United States)

    Smither, Robert K.

    2011-05-17

    A method and a device for high spatial resolution imaging of a plurality of sources of x-ray and gamma-ray radiation are provided. The device comprises a plurality of arrays, with each array comprising a plurality of elements comprising a first collimator, a diffracting crystal, a second collimator, and a detector.

  13. 77 FR 27463 - Device Improvements for Pediatric X-Ray Imaging; Public Meeting; Request for Comments

    Science.gov (United States)

    2012-05-10

    ... instructions for pediatric digital radiography (Ref. 8) and fluoroscopy (ongoing project). These materials will... follows: ``Manufacturers seeking marketing clearance for a new x-ray imaging device with a pediatric.... Manufacturers who seek marketing clearance only for general indications or do not submit adequate data to...

  14. Evaluation of x-ray diffraction enhanced imaging in the diagnosis of breast cancer.

    Science.gov (United States)

    Liu, Chenglin; Yan, Xiaohui; Zhang, Xinyi; Yang, Wentao; Peng, Weijun; Shi, Daren; Zhu, Peiping; Huang, Wanxia; Yuan, Qingxi

    2007-01-21

    The significance of the x-ray diffraction enhanced imaging (DEI) technique in the diagnosis of breast cancer and its feasibility in clinical medical imaging are evaluated. Different massive specimens including normal breast tissues, benign breast tumour tissues and malignant breast tumour tissues are imaged with the DEI method. The images are recorded respectively by CCD or x-ray film at different positions of the rocking curve and processed with a pixel-by-pixel algorithm. The characteristics of the DEI images about the normal and diseased tissues are compared. The rocking curves of a double-crystal diffractometer with various tissues are also studied. The differences in DEI images and their rocking curves are evaluated for early diagnosis of breast cancers.

  15. Impacts of Filtration on Contrast-Detail Detectability of an X-ray Imaging System

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available The purpose of this study is to investigate the impacts of added filtration on the contrast-detail detectability of a digital X-ray imaging system for small animal studies. A digital X-ray imaging system specifically designed for small animal studies was used. This system is equipped with a micro X-ray source with a tungsten target and a beryllium window filtration and a CCD-based digital detector. Molybdenum filters of 0 mm, 0.02 mm, and 0.05 mm in thickness were added. The corresponding X-ray spectra and contrast-detail detectabilities were measured using two phantoms of different thicknesses simulating breast tissue under different exposures. The added Mo filters reduced the low-energy as well as the high-energy photons, hence providing a narrowband for imaging quality improvement. In the experiments with a 1.15 cm phantom, the optimal image detectability was observed using 22 kVp and the 0.05 mm Mo filter. With the 2.15 cm phantom, the best detectability was obtained with 22 kVp and the 0.02 mm Mo filter. Our experiments showed that appropriate filtrations could reduce certain low- and high-energy components of X-ray spectra which have limited contributions to image contrast. At the same time, such filtration could improve the contrast-detail detectability, particularly at relatively low kVp and high filtration. Therefore, optimal image quality can be obtained with the same absorbed radiation dose by the subjects when appropriate filtration is used.

  16. Requirements for dynamical differential phase contrast x-ray imaging with a laboratory source

    Science.gov (United States)

    Macindoe, David; Kitchen, Marcus J.; Irvine, Sarah C.; Fouras, Andreas; Morgan, Kaye S.

    2016-12-01

    X-ray phase contrast enables weakly-attenuating structures to be imaged, with bright synchrotron sources adding the ability to capture time sequences and analyse sample dynamics. Here, we describe the translation of dynamical differential phase contrast imaging from the synchrotron to a compact x-ray source, in order to achieve this kind of time sequence imaging in the laboratory. We formulate broadly-applicable set-up guidelines for the single-grid, single-exposure imaging technique using a divergent source, exploring the experimental factors that restrict set-up size, imaging sensitivity and sample size. Experimental images are presented using the single-grid phase contrast technique with a steel attenuation grid and a liquid-metal-jet x-ray source, enabling exposure times as short as 0.5 s for dynamic imaging. Differential phase contrast images were retrieved from phantoms, incorporating noise filtering to improve the low-count images encountered when imaging dynamics using short exposures.

  17. Fundamental x-ray interaction limits in diagnostic imaging detectors: frequency-dependent Swank noise.

    Science.gov (United States)

    Hajdok, G; Battista, J J; Cunningham, I A

    2008-07-01

    A frequency-dependent x-ray Swank factor based on the "x-ray interaction" modulation transfer function and normalized noise power spectrum is determined from a Monte Carlo analysis. This factor was calculated in four converter materials: amorphous silicon (a-Si), amorphous selenium (a-Se), cesium iodide (CsI), and lead iodide (PbI2) for incident photon energies between 10 and 150 keV and various converter thicknesses. When scaled by the quantum efficiency, the x-ray Swank factor describes the best possible detective quantum efficiency (DQE) a detector can have. As such, this x-ray interaction DQE provides a target performance benchmark. It is expressed as a function of (Fourier-based) spatial frequency and takes into consideration signal and noise correlations introduced by reabsorption of Compton scatter and photoelectric characteristic emissions. It is shown that the x-ray Swank factor is largely insensitive to converter thickness for quantum efficiency values greater than 0.5. Thus, while most of the tabulated values correspond to thick converters with a quantum efficiency of 0.99, they are appropriate to use for many detectors in current use. A simple expression for the x-ray interaction DQE of digital detectors (including noise aliasing) is derived in terms of the quantum efficiency, x-ray Swank factor, detector element size, and fill factor. Good agreement is shown with DQE curves published by other investigators for each converter material, and the conditions required to achieve this ideal performance are discussed. For high-resolution imaging applications, the x-ray Swank factor indicates: (i) a-Si should only be used at low-energy (e.g., mammography); (ii) a-Se has the most promise for any application below 100 keV; and (iii) while quantum efficiency may be increased at energies just above the K edge in CsI and PbI2, this benefit is offset by a substantial drop in the x-ray Swank factor, particularly at high spatial frequencies.

  18. A High Speed, Radiation Hard X-Ray Imaging Spectroscometer for Planetary Investigations

    Science.gov (United States)

    Kraft, R. P.; Kenter, A. T.; Murray, S. S.; Martindale, A.; Pearson, J.; Gladstone, R.; Branduardi-Raymont, G.; Elsner, R.; Kimura, T.; Ezoe, Y.; Grant, C.; Roediger, E.; Howell, R.; Elvis, M.; Smith, R.; Campbell, B.; Morgenthaler, J.; Kravens, T.; Steffl, A. J.; Hong, J.

    2014-01-01

    X-ray observations provide a unique window into fundamental processes in planetary physics, and one that is complementary to observations obtained at other wavelengths. We propose to develop an X-ray imaging spectrometer (0.1-10 keV band) that, on orbital planetary missions, would measure the elemental composition, density, and temperature of the hot plasma in gas giant magnetospheres, the interaction of the Solar wind with the upper atmospheres of terrestrial planets, and map the elemental composition of the surfaces of the Galilean moons and rocky or icy airless systems on spatial scales as small as a few meters. The X-ray emission from gas giants, terrestrial planets and moons with atmospheres, displays diverse characteristics that depend on the Solar wind's interaction with their upper atmospheres and/or magnetospheres. Our imaging spectrometer, as part of a dedicated mission to a gas giant, will be a paradigm changing technology. On a mission to the Jovian system, our baseline instrument would map the elemental composition of the rocky and icy surfaces of the Galilean moons via particle-induced X-ray fluorescence. This instrument would also measure the temperature, density and elemental abundance of the thermal plasma in the magnetosphere and in the Io plasma torus (IPT), explore the interaction of the Solar wind with the magnetosphere, and characterize the spectrum, flux, and temporal variability of X-ray emission from the polar auroras. We will constrain both the mode of energy transport and the effective transport coefficients in the IPT and throughout the Jovian magnetosphere by comparing temporal and spatial variations of the X-ray emitting plasma with those seen from the cooler but energetically dominant 5 eV plasma.

  19. X-ray intravital microscopy for functional imaging in rat hearts using synchrotron radiation coronary microangiography

    Energy Technology Data Exchange (ETDEWEB)

    Umetani, K. [Japan Synchrotron Radiation Research Institute, SPring-8, Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Fukushima, K. [National Cerebral and Cardiovascular Center Hospital, Fujishirodai, Suita-shi, Osaka 565-8565 (Japan)

    2013-03-15

    An X-ray intravital microscopy technique was developed to enable in vivo visualization of the coronary, cerebral, and pulmonary arteries in rats without exposure of organs and with spatial resolution in the micrometer range and temporal resolution in the millisecond range. We have refined the system continually in terms of the spatial resolution and exposure time. X-rays transmitted through an object are detected by an X-ray direct-conversion type detector, which incorporates an X-ray SATICON pickup tube. The spatial resolution has been improved to 6 {mu}m, yielding sharp images of small arteries. The exposure time has been shortened to around 2 ms using a new rotating-disk X-ray shutter, enabling imaging of beating rat hearts. Quantitative evaluations of the X-ray intravital microscopy technique were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. The smallest-diameter vessel viewed for measurements is determined primarily by the concentration of iodinated contrast material. The iodine concentration depends on the injection technique. We used ex vivo rat hearts under Langendorff perfusion for accurate evaluation. After the contrast agent is injected into the origin of the aorta in an isolated perfused rat heart, the contrast agent is delivered directly into the coronary arteries with minimum dilution. The vascular internal diameter response of coronary arterial circulation is analyzed to evaluate the vessel function. Small blood vessels of more than about 50 {mu}m diameters were visualized clearly at heart rates of around 300 beats/min. Vasodilation compared to the control was observed quantitatively using drug manipulation. Furthermore, the apparent increase in the number of small vessels with diameters of less than about 50 {mu}m was observed after the vasoactive agents increased the diameters of invisible small blood vessels to visible sizes. This technique is expected to offer the potential for direct

  20. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... that might interfere with the x-ray images. Women should always inform their physician and x-ray ... Safety page for more information about radiation dose. Women should always inform their physician or x-ray ...

  1. Emphysema early diagnosis using X-ray diffraction enhanced imaging at synchrotron light source

    OpenAIRE

    Dong, Linan; Li, Jun; Jian, Wushuai; Zhang, Lu; Wu, Mingshu; Shi, Hongli; Luo, Shuqian

    2014-01-01

    Background Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide, and emphysema is a common component of COPD. Currently, it is very difficult to detect early stage emphysema using conventional radiographic imaging without contrast agents, because the change in X-ray attenuation is not detectable with absorption-based radiography. Compared with the absorption-based CT, phase contrast imaging has more advantages in soft tissue imaging, b...

  2. Scintillating Quantum Dots for Imaging X-rays (SQDIX) for Aircraft Inspection

    Science.gov (United States)

    Burke, Eric (Principal Investigator); Williams, Phillip (Principal Investigator); Dehaven, Stan

    2015-01-01

    Scintillation is the process currently employed by conventional x-ray detectors to create x-ray images. Scintillating quantum dots or nano-crystals (StQDs) are a novel, nanometer-scale material that upon excitation by x-rays, re-emit the absorbed energy as visible light. StQDs theoretically have higher output efficiency than conventional scintillating materials and are more environmental friendly. This paper will present the characterization of several critical elements in the use of StQDs that have been performed along a path to the use of this technology in wide spread x-ray imaging. Initial work on the SQDIX system has shown great promise to create state-of-the-art sensors using StQDs as a sensor material. In addition, this work also demonstrates a high degree of promise using StQDs in microstructured fiber optics. Using the microstructured fiber as a light guide could greatly increase the capture efficiency a StQDs based imaging sensor.

  3. Synchrotron x-ray imaging of acoustic cavitation bubbles induced by acoustic excitation

    Science.gov (United States)

    Jung, Sung Yong; Park, Han Wook; Park, Sung Ho; Lee, Sang Joon

    2017-04-01

    The cavitation induced by acoustic excitation has been widely applied in various biomedical applications because cavitation bubbles can enhance the exchanges of mass and energy. In order to minimize the hazardous effects of the induced cavitation, it is essential to understand the spatial distribution of cavitation bubbles. The spatial distribution of cavitation bubbles visualized by the synchrotron x-ray imaging technique is compared to that obtained with a conventional x-ray tube. Cavitation bubbles with high density in the region close to the tip of the probe are visualized using the synchrotron x-ray imaging technique, however, the spatial distribution of cavitation bubbles in the whole ultrasound field is not detected. In this study, the effects of the ultrasound power of acoustic excitation and working medium on the shape and density of the induced cavitation bubbles are examined. As a result, the synchrotron x-ray imaging technique is useful for visualizing spatial distributions of cavitation bubbles, and it could be used for optimizing the operation conditions of acoustic cavitation.

  4. Radiation exposure in X-ray-based imaging techniques used in osteoporosis

    Energy Technology Data Exchange (ETDEWEB)

    Damilakis, John [University of Crete, Department of Medical Physics, Faculty of Medicine, P.O. Box 2208, Iraklion, Crete (Greece); Adams, Judith E. [University of Manchester, Imaging Science and Biomedical Engineering, Manchester (United Kingdom); Manchester Royal Infirmary, Radiology Department, Manchester (United Kingdom); Guglielmi, Giuseppe [Scientific Institute Hospital San Giovanni Rotondo, Department of Radiology, San Giovanni Rotondo (Italy); University of Foggia, Foggia (Italy); Link, Thomas M. [University of California, Department of Radiology and Biomedical Imaging, San Francisco, CA (United States)

    2010-11-15

    Recent advances in medical X-ray imaging have enabled the development of new techniques capable of assessing not only bone quantity but also structure. This article provides (a) a brief review of the current X-ray methods used for quantitative assessment of the skeleton, (b) data on the levels of radiation exposure associated with these methods and (c) information about radiation safety issues. Radiation doses associated with dual-energy X-ray absorptiometry are very low. However, as with any X-ray imaging technique, each particular examination must always be clinically justified. When an examination is justified, the emphasis must be on dose optimisation of imaging protocols. Dose optimisation is more important for paediatric examinations because children are more vulnerable to radiation than adults. Methods based on multi-detector CT (MDCT) are associated with higher radiation doses. New 3D volumetric hip and spine quantitative computed tomography (QCT) techniques and high-resolution MDCT for evaluation of bone structure deliver doses to patients from 1 to 3 mSv. Low-dose protocols are needed to reduce radiation exposure from these methods and minimise associated health risks. (orig.)

  5. Three-dimensional coherent X-ray diffraction imaging of a whole, frozen-hydrated cell

    CERN Document Server

    Rodriguez, Jose A; Chen, Chien-Chun; Huang, Zhifeng; Jiang, Huaidong; Raines, Kevin S; Nam, Daewoong; Chen, Allan L; Pryor, A J; Wiegart, Lutz; Song, Changyong; Madsen, Anders; Chushkin, Yuriy; Zontone, Federico; Bradley, Peter J; Miao, Jianwei

    2014-01-01

    A structural understanding of whole cells in three dimensions at high spatial resolution remains a significant challenge and, in the case of X-rays, has been limited by radiation damage. By alleviating this limitation, cryogenic coherent diffraction imaging (cryo-CDI) could bridge the important resolution gap between optical and electron microscopy in bio-imaging. Here, we report for the first time 3D cryo-CDI of a whole, frozen-hydrated cell - in this case a Neospora caninum tachyzoite - using 8 keV X-rays. Our 3D reconstruction reveals the surface and internal morphology of the cell, including its complex, polarized sub-cellular architecture with a 3D resolution of ~75-100 nm, which is presently limited by the coherent X-ray flux and detector size. Given the imminent improvement in the coherent X-ray flux at the facilities worldwide, our work forecasts the possibility of routine 3D imaging of frozen-hydrated cells with spatial resolutions in the tens of nanometres.

  6. The first X-ray imaging spectroscopy of quiescent solar active regions with NuSTAR

    CERN Document Server

    Hannah, I G; Smith, D M; Glesener, L; Krucker, S; Hudson, H S; Madsen, K K; Marsh, A; White, S M; Caspi, A; Shih, A Y; Harrison, F A; Stern, D; Boggs, S E; Christensen, F E; Craig, W W; Hailey, C J; Zhang, W W

    2016-01-01

    We present the first observations of quiescent active regions (ARs) using NuSTAR, a focusing hard X-ray telescope capable of studying faint solar emission from high temperature and non-thermal sources. We analyze the first directly imaged and spectrally resolved X-rays above 2~keV from non-flaring ARs, observed near the west limb on 2014 November 1. The NuSTAR X-ray images match bright features seen in extreme ultraviolet and soft X-rays. The NuSTAR imaging spectroscopy is consistent with isothermal emission of temperatures $3.1-4.4$~MK and emission measures $1-8\\times 10^{46}$~cm$^{-3}$. We do not observe emission above 5~MK but our short effective exposure times restrict the spectral dynamic range. With few counts above 6~keV, we can place constraints on the presence of an additional hotter component between 5 and 12~MK of $\\sim 10^{46}$cm$^{-3}$ and $\\sim 10^{43}$ cm$^{-3}$, respectively, at least an order of magnitude stricter than previous limits. With longer duration observations and a weakening solar c...

  7. First set of gated x-ray imaging diagnostics for the Laser Megajoule facility

    Science.gov (United States)

    Rosch, R.; Trosseille, C.; Caillaud, T.; Allouche, V.; Bourgade, J. L.; Briat, M.; Brunel, P.; Burillo, M.; Casner, A.; Depierreux, S.; Gontier, D.; Jadaud, J. P.; Le Breton, J. P.; Llavador, P.; Loupias, B.; Miquel, J. L.; Oudot, G.; Perez, S.; Raimbourg, J.; Rousseau, A.; Rousseaux, C.; Rubbelynck, C.; Stemmler, P.; Troussel, P.; Ulmer, J. L.; Wrobel, R.; Beauvais, P.; Pallet, M.; Prevot, V.

    2016-03-01

    The Laser Megajoule (LMJ) facility located at CEA/CESTA started to operate in the early 2014 with two quadruplets (20 kJ at 351 nm) focused on target for the first experimental campaign. We present here the first set of gated x-ray imaging (GXI) diagnostics implemented on LMJ since mid-2014. This set consists of two imaging diagnostics with spatial, temporal, and broadband spectral resolution. These diagnostics will give basic measurements, during the entire life of the facility, such as position, structure, and balance of beams, but they will also be used to characterize gas filled target implosion symmetry and timing, to study x-ray radiography and hydrodynamic instabilities. The design requires a vulnerability approach, because components will operate in a harsh environment induced by neutron fluxes, gamma rays, debris, and shrapnel. Grazing incidence x-ray microscopes are fielded as far as possible away from the target to minimize potential damage and signal noise due to these sources. These imaging diagnostics incorporate microscopes with large source-to-optic distance and large size gated microchannel plate detectors. Microscopes include optics with grazing incidence mirrors, pinholes, and refractive lenses. Spatial, temporal, and spectral performances have been measured on x-ray tubes and UV lasers at CEA-DIF and at Physikalisch-Technische Bundesanstalt BESSY II synchrotron prior to be set on LMJ. GXI-1 and GXI-2 designs, metrology, and first experiments on LMJ are presented here.

  8. Relaxed Linearized Algorithms for Faster X-Ray CT Image Reconstruction.

    Science.gov (United States)

    Nien, Hung; Fessler, Jeffrey A

    2016-04-01

    Statistical image reconstruction (SIR) methods are studied extensively for X-ray computed tomography (CT) due to the potential of acquiring CT scans with reduced X-ray dose while maintaining image quality. However, the longer reconstruction time of SIR methods hinders their use in X-ray CT in practice. To accelerate statistical methods, many optimization techniques have been investigated. Over-relaxation is a common technique to speed up convergence of iterative algorithms. For instance, using a relaxation parameter that is close to two in alternating direction method of multipliers (ADMM) has been shown to speed up convergence significantly. This paper proposes a relaxed linearized augmented Lagrangian (AL) method that shows theoretical faster convergence rate with over-relaxation and applies the proposed relaxed linearized AL method to X-ray CT image reconstruction problems. Experimental results with both simulated and real CT scan data show that the proposed relaxed algorithm (with ordered-subsets [OS] acceleration) is about twice as fast as the existing unrelaxed fast algorithms, with negligible computation and memory overhead.

  9. Soft X ray/extreme ultraviolet images of the solar atmosphere with normal incidence multilayer optics

    Science.gov (United States)

    Lindblom, Joakim Fredrik

    The first high resolution Soft X-Ray/Extreme Ultraviolet (XUV) images of the Sun with normal incidence multilayer optics were obtained by the Standford/MSFC Rocket X-Ray Spectroheliograph on 23 Oct. 1987. Numerous images at selected wavelengths from 8 to 256 A were obtained simultaneously by the diverse array of telescopes flown on-board the experiment. These telescopes included single reflection normal incidence multilayer systems (Herschelian), double reflection multilayer systems (Cassegrain), a grazing incidence mirror system (Wolter-Schwarzschild), and hybrid systems using normal incidence multilayer optics in conjunction with the grazing incidence primary (Wolter-Cassegrain). Filters comprised of approximately 1700 A thick aluminum supported on a nickel mesh were used to transmit the soft x ray/EUV radiation while preventing the intense visible light emission of the Sun from fogging the sensitive experimental T-grain photographic emulsions. These systems yielded high resolution soft x ray/EUV images of the solar corona and transition region, which reveal magnetically confined loops of hot solar plasma, coronal plumes, polar coronal holes, supergranulation, and features associated with overlying cool prominences. The development, testing, and operation of the experiments, and the results from the flight are described. The development of a second generation experiment, the Multi-Spectral Solar Telescope Array, which is scheduled to fly in the summer of 1990, and a recently approved Space Station experiment, the Ultra-High Resolution XUV Spectroheliograph, which is scheduled to fly in 1996 are also described.

  10. Simulations of multi-contrast x-ray imaging using near-field speckles

    Energy Technology Data Exchange (ETDEWEB)

    Zdora, Marie-Christine [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom and Department of Physics & Astronomy, University College London, London, WC1E 6BT (United Kingdom); Thibault, Pierre [Department of Physics & Astronomy, University College London, London, WC1E 6BT (United Kingdom); Herzen, Julia; Pfeiffer, Franz [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Zanette, Irene [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE (United Kingdom); Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany)

    2016-01-28

    X-ray dark-field and phase-contrast imaging using near-field speckles is a novel technique that overcomes limitations inherent in conventional absorption x-ray imaging, i.e. poor contrast for features with similar density. Speckle-based imaging yields a wealth of information with a simple setup tolerant to polychromatic and divergent beams, and simple data acquisition and analysis procedures. Here, we present a simulation software used to model the image formation with the speckle-based technique, and we compare simulated results on a phantom sample with experimental synchrotron data. Thorough simulation of a speckle-based imaging experiment will help for better understanding and optimising the technique itself.

  11. Hard X-Ray Imaging of Individual Spectral Components in Solar Flares

    CERN Document Server

    Caspi, Amir; McTiernan, James M; Krucker, Säm

    2015-01-01

    We present a new analytical technique, combining Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) high-resolution imaging and spectroscopic observations, to visualize solar flare emission as a function of spectral component (e.g., isothermal temperature) rather than energy. This computationally inexpensive technique is applicable to all spatially-invariant spectral forms and is useful for visualizing spectroscopically-determined individual sources and placing them in context, e.g., comparing multiple isothermal sources with nonthermal emission locations. For example, while extreme ultraviolet images can usually be closely identified with narrow temperature ranges, due to the emission being primarily from spectral lines of specific ion species, X-ray images are dominated by continuum emission and therefore have a broad temperature response, making it difficult to identify sources of specific temperatures regardless of the energy band of the image. We combine RHESSI calibrated X-ray visibilities wi...

  12. Influence of angle's ranges for recording an X-ray fluorescence hologram on reconstructed atomic images

    Institute of Scientific and Technical Information of China (English)

    XIE Hong-Lan; CHEN Jian-Wen; GAO Hong-Yi; ZHU Hua-Feng; LI Ru-Xin; XU Zhi-Zhan

    2004-01-01

    X-ray fluorescence holography (XFH) is a novel method for three-dimensional (3D) imaging of atomic structure. Theoretically, in an XFH experiment, one has to measure the fluorescence energy on a spherical surface to get well-resolved 3D images of atoms. But in practice, the experimental system arrangement does not allow the measurement of the fluorescent intensity oscillations in the full sphere. The holographic information losses because of the limited sampling range (less than 4π) will directly result in defective reconstructed atomic images. In this work, the atomic image of a Fe single crystal (001) was reconstructed by numerically simulating X-ray fluorescence holograms of the crystal at different recording angle's ranges and step lengths. Influences of the ranges of azimuth angles and polar angles and the step length of polar angles on the reconstructed atomic images were discussed.

  13. Development of gas microstrip detectors for digital x-ray imaging and radiation dosimetry

    CERN Document Server

    Dixit, M S; Dubeau, J; Gobbi, D G; Johns, P C; Karlen, Dean A; Oakham, F G; Waker, A J

    1998-01-01

    Our recent work in the application of gas microstrip detector (GMD) technology to the fields of digital X-ray imaging and radiation dosimetry Is described. The GMD can measure the position and the energy of individual photons at the high counting rates encountered in X-ray imaging. GMD-based imaging systems have high detective quantum efficiency and permit improvement of image quality and contrast using display windowing and measured energy information. Results are presented on the performance of a prototype GMD imaging system operated with a xenon/methane 90/10 gas mixture at 1 atm. Results are also presented on the performance of a GMD filled with tissue equivalent gases for applications in the field of radiation dosimetry in mixed neutron and gamma fields. The results show that the GMD can be used for dosimetric discrimination between different types of radiation in mixed-field environments.

  14. Vision 20/20: Single photon counting x-ray detectors in medical imaging.

    Science.gov (United States)

    Taguchi, Katsuyuki; Iwanczyk, Jan S

    2013-10-01

    Photon counting detectors (PCDs) with energy discrimination capabilities have been developed for medical x-ray computed tomography (CT) and x-ray (XR) imaging. Using detection mechanisms that are completely different from the current energy integrating detectors and measuring the material information of the object to be imaged, these PCDs have the potential not only to improve the current CT and XR images, such as dose reduction, but also to open revolutionary novel applications such as molecular CT and XR imaging. The performance of PCDs is not flawless, however, and it seems extremely challenging to develop PCDs with close to ideal characteristics. In this paper, the authors offer our vision for the future of PCD-CT and PCD-XR with the review of the current status and the prediction of (1) detector technologies, (2) imaging technologies, (3) system technologies, and (4) potential clinical benefits with PCDs.

  15. Development of low-noise high-speed analog ASIC for X-ray CCD cameras and wide-band X-ray imaging sensors

    Science.gov (United States)

    Nakajima, Hiroshi; Hirose, Shin-nosuke; Imatani, Ritsuko; Nagino, Ryo; Anabuki, Naohisa; Hayashida, Kiyoshi; Tsunemi, Hiroshi; Doty, John P.; Ikeda, Hirokazu; Kitamura, Hisashi; Uchihori, Yukio

    2016-09-01

    We report on the development and performance evaluation of the mixed-signal Application Specific Integrated Circuit (ASIC) developed for the signal processing of onboard X-ray CCD cameras and various types of X-ray imaging sensors in astrophysics. The quick and low-noise readout is essential for the pile-up free imaging spectroscopy with a future X-ray telescope. Our goal is the readout noise of 5e- r . m . s . at the pixel rate of 1 Mpix/s that is about 10 times faster than those of the currently working detectors. We successfully developed a low-noise ASIC as the front-end electronics of the Soft X-ray Imager onboard Hitomi that was launched on February 17, 2016. However, it has two analog-to-digital converters per chain due to the limited processing speed and hence we need to correct the difference of gain to obtain the X-ray spectra. Furthermore, its input equivalent noise performance is not satisfactory (> 100 μV) at the pixel rate higher than 500 kpix/s. Then we upgrade the design of the ASIC with the fourth-order ΔΣ modulators to enhance its inherent noise-shaping performance. Its performance is measured using pseudo CCD signals with variable processing speed. Although its input equivalent noise is comparable with the conventional one, the integrated non-linearity (0.1%) improves to about the half of that of the conventional one. The radiation tolerance is also measured with regard to the total ionizing dose effect and the single event latch-up using protons and Xenon, respectively. The former experiment shows that all of the performances does not change after imposing the dose corresponding to 590 years in a low earth orbit. We also put the upper limit on the frequency of the latch-up to be once per 48 years.

  16. Applications of Novel X-Ray Imaging Modalities in Food Science

    DEFF Research Database (Denmark)

    Nielsen, Mikkel Schou

    process. From the initial step of taking the image, the information in the image needs to be translated through image analysis before data analysis can be applied to treat the image quantitatively and answer the questions at hand. In this work, a number of studies were carried out to investigate possible...... applications of novel X-ray imaging modalities within food science. The first two studies mainly concern the image acquisition process of taking the image. Using dark-eld radiography, raw, frozen and defrosted fruit were distinguished, and structural changes in barley seeds during germination were monitored...

  17. Large-format distributed read-out imaging devices for X-ray imaging spectroscopy

    Science.gov (United States)

    den Hartog, Roland; Kozorezov, A.; Martin, D.; Brammertz, G.; Verhoeve, P.; Peacock, A.; Scholze, F.; Goldie, D. J.

    2002-02-01

    We present an experimental study of the performance of Distributed Read-Out Imaging Devices (DROIDs), based on two Ta/Al-based superconducting tunnel junctions (STJs) placed on either side of a Ta absorber strip. We focus our discussion on the prospects of building large-format photon-counting imaging spectrometers for applications at optical, UV and soft X-ray energies. Tunnel-limited spectroscopic resolutions have already been demonstrated for optical photons. With a 20×100 μm2 absorber we have measured an intrinsic energy resolution of 2 eV FWHM for 500 eV photons. This demonstrates that at soft X-ray energies resolutions close to the tunnel limit are also feasible for this type of detectors. A detailed analysis of pulse-shapes with numerical models allows us to assess the main parameters that determine the performance of these detectors. Extrapolation of these models indicates that it is possible to extend the length of the absorber to 1.5 mm, without a serious degradation of the detector's performance. .

  18. Large-format distributed readout imaging devices for x-ray imaging spectroscopy

    Science.gov (United States)

    den Hartog, Roland H.; Kozorezov, Alex G.; Martin, Didier D.; Brammertz, G.; Verhoeve, Peter; Peacock, Anthony J.; Scholze, Frank; Goldie, D. J.

    2002-01-01

    We present an experimental study of the performance of one-dimensional Distributed Read-Out Imaging Devices (DROIDs), based on two Ta/Al-based STJs placed on either side of a Ta absorber strip. We focus our discussion on the prospects of building large-format photon-counting imaging spectrometers for applications at soft X-ray energies. Tunnel-limited spectroscopical resolutions have already been demonstrated for optical photons. With a 20 x 100 micrometers 2 absorber we have measured an intrinsic energy resolution of 2.1 eV FWHM for 500 eV photons. This demonstrates that at soft X-ray energies resolutions close to the tunnel limit are also feasible for these type of detectors. A detailed analysis of pulse-shapes with analytical models allows us to assess the main parameters that determine the performance of these detectors. In particular, we discuss the dependence of the quasiparticle diffusion constant on the temperature of the absorber. Extrapolation of these models indicates that it is possible to extend the length of the absorber to 1.5 mm, without a serious degradation of the detector's performance.

  19. X-ray imaging with grazing-incidence microscopes developed for the LIL program.

    Science.gov (United States)

    Rosch, R; Boutin, J Y; le Breton, J P; Gontier, D; Jadaud, J P; Reverdin, C; Soullié, G; Lidove, G; Maroni, R

    2007-03-01

    This article describes x-ray imaging with grazing-incidence microscopes, developed for the experimental program carried out on the Ligne d'Integration Laser (LIL) facility [J. P. Le Breton et al., Inertial Fusion Sciences and Applications 2001 (Elsevier, Paris, 2002), pp. 856-862] (24 kJ, UV-0.35 nm). The design includes a large target-to-microscope (400-700 mm) distance required by the x-ray ablation issues anticipated on the Laser MégaJoule facility [P. A. Holstein et al., Laser Part. Beams 17, 403 (1999)] (1.8 MJ) which is under construction. Two eight-image Kirkpatrick-Baez microscopes [P. Kirkpatrick and A. V. Baez J. Opt. Soc. Am. 38, 766 (1948)] with different spectral wavelength ranges and with a 400 mm source-to-mirror distance image the target on a custom-built framing camera (time resolution of approximately 80 ps). The soft x-ray version microscope is sensitive below 1 keV and its spatial resolution is better than 30 microm over a 2-mm-diam region. The hard x-ray version microscope has a 10 microm resolution over an 800-microm-diam region and is sensitive in the 1-5 keV energy range. Two other x-ray microscopes based on an association of toroidal/spherical surfaces (T/S microscopes) produce an image on a streak camera with a spatial resolution better than 30 microm over a 3 mm field of view in the direction of the camera slit. Both microscopes have been designed to have, respectively, a maximum sensitivity in the 0.1-1 and 1-5 keV energy range. We present the original design of these four microscopes and their test on a dc x-ray tube in the laboratory. The diagnostics were successfully used on LIL first experiments early in 2005. Results of soft x-ray imaging of a radiative jet during conical shaped laser interaction are shown.

  20. Possibility of single biomolecule imaging with coherent amplification of weak scattering x-ray photons.

    Science.gov (United States)

    Shintake, Tsumoru

    2008-10-01

    The number of photons produced by coherent x-ray scattering from a single biomolecule is very small because of its extremely small elastic-scattering cross section and low damage threshold. Even with a high x-ray flux of 3 x 10;{12} photons per 100-nm -diameter spot and an ultrashort pulse of 10 fs driven by a future x-ray free electron laser (x-ray FEL), it has been predicted that only a few 100 photons will be produced from the scattering of a single lysozyme molecule. In observations of scattered x rays on a detector, the transfer of energy from wave to matter is accompanied by the quantization of the photon energy. Unfortunately, x rays have a high photon energy of 12 keV at wavelengths of 1A , which is required for atomic resolution imaging. Therefore, the number of photoionization events is small, which limits the resolution of imaging of a single biomolecule. In this paper, I propose a method: instead of directly observing the photons scattered from the sample, we amplify the scattered waves by superimposing an intense coherent reference pump wave on it and record the resulting interference pattern on a planar x-ray detector. Using a nanosized gold particle as a reference pump wave source, we can collect 10;{4}-10;{5} photons in single shot imaging where the signal from a single biomolecule is amplified and recorded as two-dimensional diffraction intensity data. An iterative phase retrieval technique can be used to recover the phase information and reconstruct the image of the single biomolecule and the gold particle at the same time. In order to precisely reconstruct a faint image of the single biomolecule in Angstrom resolution, whose intensity is much lower than that of the bright gold particle, I propose a technique that combines iterative phase retrieval on the reference pump wave and the digital Fourier transform holography on the sample. By using a large number of holography data, the three-dimensional electron density map can be assembled.

  1. Distributed read-out imaging devices for x-ray imaging spectroscopy

    Science.gov (United States)

    den Hartog, Roland H.; Martin, Didier D.; Kozorezov, A. G.; Verhoeve, Peter; Rando, Nicola; Peacock, Anthony J.; Brammertz, G.; Krumrey, Michael K.; Goldie, D. J.; Venn, R.

    2000-07-01

    We present an experimental study of the performance of Distributed Read-Out Imaging Devices (DROIDs), 1- and 2-D photon-counting imaging spectrometers, based on Ta/Al-based STJs placed on a Ta absorber. Results obtained with highly collimated illumination with 10 keV X-ray photons clearly demonstrate the imaging capabilities of 2-D DROIDs. The derived spatial FWHM resolution is 7 micrometers for a 200 X 200 micrometers 2 absorber. With a 1-D DROID we have measured an intrinsic energy resolution of 15 eV FWHM for 6 keV photons. At high energies (E > 6 keV) the resolution is limited by spatial fluctuations in the qp recombination rate.

  2. A Novel Feature Extraction Scheme for Medical X-Ray Images

    Directory of Open Access Journals (Sweden)

    Prachi.G.Bhende

    2016-02-01

    Full Text Available X-ray images are gray scale images with almost the same textural characteristic. Conventional texture or color features cannot be used for appropriate categorization in medical x-ray image archives. This paper presents a novel combination of methods like GLCM, LBP and HOG for extracting distinctive invariant features from Xray images belonging to IRMA (Image Retrieval in Medical applications database that can be used to perform reliable matching between different views of an object or scene. GLCM represents the distributions of the intensities and the information about relative positions of neighboring pixels of an image. The LBP features are invariant to image scale and rotation, change in 3D viewpoint, addition of noise, and change in illumination A HOG feature vector represents local shape of an object, having edge information at plural cells. These features have been exploited in different algorithms for automatic classification of medical X-ray images. Excellent experimental results obtained in true problems of rotation invariance, particular rotation angle, demonstrate that good discrimination can be achieved with the occurrence statistics of simple rotation invariant local binary patterns.

  3. Coherent x-ray imaging of spins on nanoscale (Conference Presentation)

    Science.gov (United States)

    Shpyrko, Oleg

    2016-10-01

    Understanding electronic structure at nanometer resolution is crucial to understanding physics such as phase separation and emergent behavior in correlated electron materials. Nondestructive probes which have the ability to see beyond surfaces on nanometer length and sub-picosecond time scales can greatly enhance our understanding of these systems and will impact development of future technologies, such as magnetic storage. Polarized x-rays are an appealing choice of probe due to their penetrating power, elemental and magnetic specificity, and high spatial resolution. The resolution of traditional x-ray microscopy is limited by the nanometer precision required to fabricate x-ray optics. In this thesis, a novel approach to lensless imaging of an extended magnetic nanostructure is presented. We demonstrate this approach by imaging ferrimagnetic "maze" domains in a Gd/Fe multilayer with perpendicular anisotropy. A series of dichroic coherent diffraction patterns, ptychographically recorded, are numerically inverted using non-convex and non-linear optimization theory, and we follow the magnetic domain configuration evolution through part of its magnetization hysteresis loop by applying an external magnetic field. Unlike holographic methods, it does not require a reference wave or precision optics, and so is a far simpler experiment. In addition, it enables the imaging of samples with arbitrarily large spatial dimensions, at a spatial resolution limited solely by the coherent x-ray flux and wavelength. It can readily be extended to other non-magnetic systems that exhibit circular or linear dichroism. This approach is scalable to imaging with diffraction-limited resolution, a prospect rapidly becoming a reality in view of the new generation of phenomenally brilliant x-ray sources.

  4. Tomography of a Cryo-immobilized Yeast Cell Using Ptychographic Coherent X-Ray Diffractive Imaging.

    Science.gov (United States)

    Giewekemeyer, K; Hackenberg, C; Aquila, A; Wilke, R N; Groves, M R; Jordanova, R; Lamzin, V S; Borchers, G; Saksl, K; Zozulya, A V; Sprung, M; Mancuso, A P

    2015-11-03

    The structural investigation of noncrystalline, soft biological matter using x-rays is of rapidly increasing interest. Large-scale x-ray sources, such as synchrotrons and x-ray free electron lasers, are becoming ever brighter and make the study of such weakly scattering materials more feasible. Variants of coherent diffractive imaging (CDI) are particularly attractive, as the absence of an objective lens between sample and detector ensures that no x-ray photons scattered by a sample are lost in a limited-efficiency imaging system. Furthermore, the reconstructed complex image contains quantitative density information, most directly accessible through its phase, which is proportional to the projected electron density of the sample. If applied in three dimensions, CDI can thus recover the sample's electron density distribution. As the extension to three dimensions is accompanied by a considerable dose applied to the sample, cryogenic cooling is necessary to optimize the structural preservation of a unique sample in the beam. This, however, imposes considerable technical challenges on the experimental realization. Here, we show a route toward the solution of these challenges using ptychographic CDI (PCDI), a scanning variant of coherent imaging. We present an experimental demonstration of the combination of three-dimensional structure determination through PCDI with a cryogenically cooled biological sample--a budding yeast cell (Saccharomyces cerevisiae)--using hard (7.9 keV) synchrotron x-rays. This proof-of-principle demonstration in particular illustrates the potential of PCDI for highly sensitive, quantitative three-dimensional density determination of cryogenically cooled, hydrated, and unstained biological matter and paves the way to future studies of unique, nonreproducible biological cells at higher resolution.

  5. Silicon strip detectors for two-dimensional soft X-ray imaging at normal incidence

    Energy Technology Data Exchange (ETDEWEB)

    Rato Mendes, P. E-mail: rato@lip.pt; Abreu, M.C.; Baldazzi, G.; Bollini, D.; Cabal Rodriguez, A.E.; Dabrowski, W.; Diaz Garcia, A.; Gambaccini, M.; Giubellino, P.; Gombia, M.; Grybos, P.; Idzik, M.; Marzari-Chiesa, A.; Montano, L.M.; Prino, F.; Ramello, L.; Rodrigues, S.; Sitta, M.; Sousa, P.; Swientek, K.; Taibi, A.; Tuffanelli, A.; Wheadon, R.; Wiacek, P

    2003-08-21

    A simple prototype system for static two-dimensional soft X-ray imaging using silicon microstrip detectors irradiated at normal incidence is presented. Radiation sensors consist of single-sided silicon detectors made from 300 {mu}m thick wafers, read by RX64 ASICs. Data acquisition and control is performed by a Windows PC workstation running dedicated LabVIEW routines, connected to the sensors through a PCI-DIO-96 interface. Two-dimensional images are obtained by scanning a lead collimator with a thin slit perpendicular to the strip axis, along the whole detector size; the several strip profiles (slices) taken at each position are then put together to form a planar image. Preliminary results are presented, illustrating the high-resolution imaging capabilities of the system with soft X-rays.

  6. Computer Evaluation Of Real-Time X-Ray And Acoustic Images

    Science.gov (United States)

    Jacoby, M. H.; Loe, R. S.; Dondes, P. A.

    1983-03-01

    The weakest link in the inspection process is the subjective interpretation of data by inspectors. To overcome this troublesome fact computer based analysis systems have been developed. In the field of nondestructive evaluation (NDE) there is a large class of inspections that can benefit from computer analysis. X-ray images (both film and fluoroscopic) and acoustic images lend themselves to automatic analysis as do the one-dimensional signals associated with ultrasonic, eddy current and acoustic emission testing. Computer analysis can enhance and evaluate subtle details. Flaws can be located and measured, and accept-ance decisions made by computer in a consistent and objective manner. This paper describes the interactive, computer-based analysis of real-time x-ray images and acoustic images of graphite/epoxy adhesively bonded structures.

  7. Amorphous and Polycrystalline Photoconductors for Direct Conversion Flat Panel X-Ray Image Sensors

    Directory of Open Access Journals (Sweden)

    Karim S. Karim

    2011-05-01

    Full Text Available In the last ten to fifteen years there has been much research in using amorphous and polycrystalline semiconductors as x-ray photoconductors in various x-ray image sensor applications, most notably in flat panel x-ray imagers (FPXIs. We first outline the essential requirements for an ideal large area photoconductor for use in a FPXI, and discuss how some of the current amorphous and polycrystalline semiconductors fulfill these requirements. At present, only stabilized amorphous selenium (doped and alloyed a-Se has been commercialized, and FPXIs based on a-Se are particularly suitable for mammography, operating at the ideal limit of high detective quantum efficiency (DQE. Further, these FPXIs can also be used in real-time, and have already been used in such applications as tomosynthesis. We discuss some of the important attributes of amorphous and polycrystalline x-ray photoconductors such as their large area deposition ability, charge collection efficiency, x-ray sensitivity, DQE, modulation transfer function (MTF and the importance of the dark current. We show the importance of charge trapping in limiting not only the sensitivity but also the resolution of these detectors. Limitations on the maximum acceptable dark current and the corresponding charge collection efficiency jointly impose a practical constraint that many photoconductors fail to satisfy. We discuss the case of a-Se in which the dark current was brought down by three orders of magnitude by the use of special blocking layers to satisfy the dark current constraint. There are also a number of polycrystalline photoconductors, HgI2 and PbO being good examples, that show potential for commercialization in the same way that multilayer stabilized a-Se x-ray photoconductors were developed for commercial applications. We highlight the unique nature of avalanche multiplication in a-Se and how it has led to the development of the commercial HARP video-tube. An all solid state version of the

  8. Amorphous and polycrystalline photoconductors for direct conversion flat panel x-ray image sensors.

    Science.gov (United States)

    Kasap, Safa; Frey, Joel B; Belev, George; Tousignant, Olivier; Mani, Habib; Greenspan, Jonathan; Laperriere, Luc; Bubon, Oleksandr; Reznik, Alla; DeCrescenzo, Giovanni; Karim, Karim S; Rowlands, John A

    2011-01-01

    In the last ten to fifteen years there has been much research in using amorphous and polycrystalline semiconductors as x-ray photoconductors in various x-ray image sensor applications, most notably in flat panel x-ray imagers (FPXIs). We first outline the essential requirements for an ideal large area photoconductor for use in a FPXI, and discuss how some of the current amorphous and polycrystalline semiconductors fulfill these requirements. At present, only stabilized amorphous selenium (doped and alloyed a-Se) has been commercialized, and FPXIs based on a-Se are particularly suitable for mammography, operating at the ideal limit of high detective quantum efficiency (DQE). Further, these FPXIs can also be used in real-time, and have already been used in such applications as tomosynthesis. We discuss some of the important attributes of amorphous and polycrystalline x-ray photoconductors such as their large area deposition ability, charge collection efficiency, x-ray sensitivity, DQE, modulation transfer function (MTF) and the importance of the dark current. We show the importance of charge trapping in limiting not only the sensitivity but also the resolution of these detectors. Limitations on the maximum acceptable dark current and the corresponding charge collection efficiency jointly impose a practical constraint that many photoconductors fail to satisfy. We discuss the case of a-Se in which the dark current was brought down by three orders of magnitude by the use of special blocking layers to satisfy the dark current constraint. There are also a number of polycrystalline photoconductors, HgI(2) and PbO being good examples, that show potential for commercialization in the same way that multilayer stabilized a-Se x-ray photoconductors were developed for commercial applications. We highlight the unique nature of avalanche multiplication in a-Se and how it has led to the development of the commercial HARP video-tube. An all solid state version of the HARP has been

  9. Monochromatic X-ray propagation in multi-Z media for imaging and diagnostics including Kα Resonance Fluorescence

    Science.gov (United States)

    Westphal, Maximillian; Lim, Sara; Nahar, Sultana; Pradhan, Anil

    2016-05-01

    Aimed at monochromatic X-ray imaging and therapy, broadband, monochromatic, and quasi-monochromatic X-ray sources and propagation through low and high-Z (HZ) media were studied with numerically and experimentally. Monte Carlo simulations were performed using the software package Geant4, and a new code Photx, to simulate X-ray image contrast, depth of penetration, and total attenuation. The data show that monochromatic and quasi-monochromatic X-rays achieve improved contrast at lower absorbed radiation doses compared to conventional broadband 120 kV or CT scans. Experimental quasi-monochromatic high-intensity laser-produced plasma sources and monochromatic synchrotron beam data are compared. Physical processes responsible for X-ray photoexcitation and absorption are numerically modelled, including a novel mechanism for accelerating Kα resonance fluorescence via twin monochromatic X-ray beam. Potential applications are medical diagnostics and high-Z material detection. Acknowledgement: Ohio Supercomputer Center, Columbus, OH.

  10. High Resolution X-ray Imaging of Supernova Remnant 1987A

    CERN Document Server

    Ng, C -Y; Murray, S S; Slane, P O; Park, S; Staveley-Smith, L; Manchester, R N; Burrows, D N

    2009-01-01

    We report observations of the remnant of Supernova 1987A with the High Resolution Camera (HRC) onboard the Chandra X-ray Observatory. A direct image from the HRC resolves the annular structure of the X-ray remnant, confirming the morphology previously inferred by deconvolution of lower resolution data from the Advanced CCD Imaging Spectrometer. Detailed spatial modeling shows that the a thin ring plus a thin shell gives statistically the best description of the overall remnant structure, and suggests an outer radius 0.96" +/- 0.05" +/- 0.03" for the X-ray-emitting region, with the two uncertainties corresponding to the statistical and systematic errors, respectively. This is very similar to the radius determined by a similar modeling technique for the radio shell at a comparable epoch, in contrast to previous claims that the remnant is 10-15% smaller at X-rays than in the radio band. The HRC observations put a flux limit of 0.010 cts/s (99% confidence level, 0.08-10 keV range) on any compact source at the rem...

  11. High-Resolution X-Ray Imaging of Supernova Remnant 1987A

    Science.gov (United States)

    Ng, C.-Y.; Gaensler, B. M.; Murray, S. S.; Slane, P. O.; Park, S.; Staveley-Smith, L.; Manchester, R. N.; Burrows, D. N.

    2009-11-01

    We report observations of the remnant of supernova 1987A with the High Resolution Camera (HRC) on board the Chandra X-ray Observatory. A direct image from the HRC resolves the annular structure of the X-ray remnant, confirming the morphology previously inferred by deconvolution of lower resolution data from the Advanced CCD Imaging Spectrometer. Detailed spatial modeling shows that a thin ring plus a thin shell gives statistically the best description of the overall remnant structure, and suggests an outer radius of 0farcs96 ± 0farcs05 ± 0farcs03 for the X-ray-emitting region, with the two uncertainties corresponding to the statistical and systematic errors, respectively. This is very similar to the radius determined by a similar modeling technique for the radio shell at a comparable epoch, in contrast to previous claims that the remnant is 10%-15% smaller at X-rays than in the radio band. The HRC observations put a flux limit of 0.010 counts s-1 (99% confidence level, 0.08-10 keV range) on any compact source at the remnant center. Assuming the same foreground neutral hydrogen column density as toward the remnant, this allows us to rule out an unobscured neutron star with surface temperature T ∞ > 2.5 MK observed at infinity, a bright pulsar wind nebula or a magnetar.

  12. Modeling the Expected Performance of the REgoligth X-ray Imaging Spectrometer (REXIS)

    CERN Document Server

    Inamdar, Niraj K; Hong, Jae Sub; Allen, Branden; Grindlay, Jonathan; Masterson, Rebecca A

    2014-01-01

    OSIRIS-REx is the third spacecraft in the NASA New Frontiers Program and is planned for launch in 2016. OSIRIS-REx will orbit the near-Earth asteroid (101955) Bennu, characterize it, and return a sample of the asteroid's regolith back to Earth. The Regolith X-ray Imaging Spectrometer (REXIS) is an instrument on OSIRIS-REx designed and built by students at MIT and Harvard. The purpose of REXIS is to collect and image sun-induced fluorescent X-rays emitted by Bennu, thereby providing spectroscopic information related to the elemental makeup of the asteroid regolith and the distribution of features over its surface. Telescopic reflectance spectra suggest a CI or CM chondrite analog meteorite class for Bennu, where this primitive nature strongly motivates its study. A number of factors, however, will influence the generation, measurement, and interpretation of the X-ray spectra measured by REXIS. These include: the compositional nature and heterogeneity of Bennu, the time-variable Solar state, X-ray detector char...

  13. Low dose digital X-ray imaging with avalanche amorphous selenium

    Science.gov (United States)

    Scheuermann, James R.; Goldan, Amir H.; Tousignant, Olivier; Léveillé, Sébastien; Zhao, Wei

    2015-03-01

    Active Matrix Flat Panel Imagers (AMFPI) based on an array of thin film transistors (TFT) have become the dominant technology for digital x-ray imaging. In low dose applications, the performance of both direct and indirect conversion detectors are limited by the electronic noise associated with the TFT array. New concepts of direct and indirect detectors have been proposed using avalanche amorphous selenium (a-Se), referred to as high gain avalanche rushing photoconductor (HARP). The indirect detector utilizes a planar layer of HARP to detect light from an x-ray scintillator and amplify the photogenerated charge. The direct detector utilizes separate interaction (non-avalanche) and amplification (avalanche) regions within the a-Se to achieve depth-independent signal gain. Both detectors require the development of large area, solid state HARP. We have previously reported the first avalanche gain in a-Se with deposition techniques scalable to large area detectors. The goal of the present work is to demonstrate the feasibility of large area HARP fabrication in an a-Se deposition facility established for commercial large area AMFPI. We also examine the effect of alternative pixel electrode materials on avalanche gain. The results show that avalanche gain > 50 is achievable in the HARP layers developed in large area coaters, which is sufficient to achieve x-ray quantum noise limited performance down to a single x-ray photon per pixel. Both chromium (Cr) and indium tin oxide (ITO) have been successfully tested as pixel electrodes.

  14. The First Focused Hard X-ray Images of the Sun with NuSTAR

    CERN Document Server

    Grefenstette, Brian W; Krucker, Säm; Hudson, Hugh; Hannah, Iain G; Smith, David M; Vogel, Julia K; White, Stephen M; Madsen, Kristin K; Marsh, Andrew J; Caspi, Amir; Chen, Bin; Shih, Albert; Kuhar, Matej; Boggs, Steven E; Christensen, Finn E; Craig, William W; Forster, Karl; Hailey, Charles J; Harrison, Fiona A; Miyasaka, Hiromasa; Stern, Daniel; Zhang, William W

    2016-01-01

    We present results from the the first campaign of dedicated solar observations undertaken by the \\textit{Nuclear Spectroscopic Telescope ARray} ({\\em NuSTAR}) hard X-ray telescope. Designed as an astrophysics mission, {\\em NuSTAR} nonetheless has the capability of directly imaging the Sun at hard X-ray energies ($>$3~keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where \\textit{NuSTAR} will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with \\textit{NuSTAR}, their limitations and complications, and the procedures developed to optimize solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, hard X-ray emission from high in the solar corona, and full-disk hard X-ray images of the Sun.

  15. Preliminary Research on Dual-Energy X-Ray Phase-Contrast Imaging

    CERN Document Server

    Han, Huajie; Gao, Kun; Wang, Zhili; Zhang, Can; Yang, Meng; Zhang, Kai; Zhu, Peiping

    2015-01-01

    Dual-energy X-ray absorptiometry (DEXA) has been widely applied to measure bone mineral density (BMD) and soft-tissue composition of human body. However, the use of DEXA is greatly limited for low-Z materials such as soft tissues due to their weak absorption. While X-ray phase-contrast imaging (XPCI) shows significantly improved contrast in comparison with the conventional standard absorption-based X-ray imaging for soft tissues. In this paper, we propose a novel X-ray phase-contrast method to measure the area density of low-Z materials, including a single-energy method and a dual-energy method. The single-energy method is for the area density calculation of one low-Z material, while the dual-energy method is aiming to calculate the area densities of two low-Z materials simultaneously. Comparing the experimental and simulation results with the theoretic ones, the new method proves to have the potential to replace DEXA in area density measurement. The new method sets the prerequisites for future precise and lo...

  16. Segmentation of Bone Structure in X-ray Images using Convolutional Neural Network

    Directory of Open Access Journals (Sweden)

    CERNAZANU-GLAVAN, C.

    2013-02-01

    Full Text Available The segmentation process represents a first step necessary for any automatic method of extracting information from an image. In the case of X-ray images, through segmentation we can differentiate the bone tissue from the rest of the image. There are nowadays several segmentation techniques, but in general, they all require the human intervention in the segmentation process. Consequently, this article proposes a new segmentation method for the X-ray images using a Convolutional Neural Network (CNN. In present, the convolutional networks are the best techniques for image segmentation. This fact is demonstrated by their wide usage in all the fields, including the medical one. As the X-ray images have large dimensions, for reducing the training time, the method proposed by the present article selects only certain areas (maximum interest areas from the entire image. The neural network is used as pixel classifier thus causing the label of each pixel (bone or none-bone from a raw pixel values in a square area. We will also present the method through which the network final configuration was chosen and we will make a comparative analysis with other 3 CNN configurations. The network chosen by us obtained the best results for all the evaluation metrics used, i.e. warping error, rand error and pixel error.

  17. Domain and range decomposition methods for coded aperture x-ray coherent scatter imaging

    Science.gov (United States)

    Odinaka, Ikenna; Kaganovsky, Yan; O'Sullivan, Joseph A.; Politte, David G.; Holmgren, Andrew D.; Greenberg, Joel A.; Carin, Lawrence; Brady, David J.

    2016-05-01

    Coded aperture X-ray coherent scatter imaging is a novel modality for ascertaining the molecular structure of an object. Measurements from different spatial locations and spectral channels in the object are multiplexed through a radiopaque material (coded aperture) onto the detectors. Iterative algorithms such as penalized expectation maximization (EM) and fully separable spectrally-grouped edge-preserving reconstruction have been proposed to recover the spatially-dependent coherent scatter spectral image from the multiplexed measurements. Such image recovery methods fall into the category of domain decomposition methods since they recover independent pieces of the image at a time. Ordered subsets has also been utilized in conjunction with penalized EM to accelerate its convergence. Ordered subsets is a range decomposition method because it uses parts of the measurements at a time to recover the image. In this paper, we analyze domain and range decomposition methods as they apply to coded aperture X-ray coherent scatter imaging using a spectrally-grouped edge-preserving regularizer and discuss the implications of the increased availability of parallel computational architecture on the choice of decomposition methods. We present results of applying the decomposition methods on experimental coded aperture X-ray coherent scatter measurements. Based on the results, an underlying observation is that updating different parts of the image or using different parts of the measurements in parallel, decreases the rate of convergence, whereas using the parts sequentially can accelerate the rate of convergence.

  18. Deep Chandra X-ray Imaging of a Nearby Radio Galaxy 4C+29.30: X-ray/Radio Connection

    CERN Document Server

    Siemiginowska, Aneta; Cheung, Chi C; Aldcroft, Thomas L; Bechtold, Jill; Burke, D J; Evans, Daniel; Holt, Joanna; Jamrozy, Marek; Migliori, Giulia; .,

    2012-01-01

    We report results from our deep Chandra X-ray observations of a nearby radio galaxy, 4C+29.30 (z=0.0647). The Chandra image resolves structures on sub-arcsec to arcsec scales, revealing complex X-ray morphology and detecting the main radio features: the nucleus, a jet, hotspots, and lobes. The nucleus is absorbed (N(H)=3.95 (+0.27/-0.33)x10^23 atoms/cm^2) with an unabsorbed luminosity of L(2-10 keV) ~ (5.08 +/-0.52) 10^43 erg/s characteristic of Type 2 AGN. Regions of soft (<2 keV) X-ray emission that trace the hot interstellar medium (ISM) are correlated with radio structures along the main radio axis indicating a strong relation between the two. The X-ray emission beyond the radio source correlates with the morphology of optical line-emitting regions. We measured the ISM temperature in several regions across the galaxy to be kT ~ 0.5 with slightly higher temperatures (of a few keV) in the center and in the vicinity of the radio hotspots. Assuming these regions were heated by weak shocks driven by the exp...

  19. Prototyping a Global Soft X-ray Imaging Instrument for Heliophysics, Planetary Science, and Astrophysics Science

    Science.gov (United States)

    Collier, Michael R.; Porter, F. Scott; Sibeck, David G.; Carter, Jenny A.; Chiao, Meng P.; Chornay, Dennis J.; Cravens, Thomas; Galeazzi, Massimiliano; Keller, John W.; Koutroumpa, Dimitra; Kuntz, Kip; Read, Any M.; Robertson, Ina P.; Sembay, Steve; Snowden, Steven; Thomas, Nick

    2012-01-01

    We describe current progress in the development of a prototype wide field-of-view soft X-ray imager that employs Lobster-eye optics and targets heliophysics, planetary, and astrophysics science. The prototype will provide proof-of-concept for a future flight instrument capable of imaging the entire dayside magnetosheath from outside the magnetosphere. Such an instrument was proposed for the FSA AXIOM mission

  20. Machine recognition of navel orange worm damage in X-ray images of pistachio nuts

    Energy Technology Data Exchange (ETDEWEB)

    Keagy, P.M.; Schatzki, T.F. [USDA-ARS Western Regional Research Center, Albany, CA (United States); Parvin, B. [Lawrence Berkeley Lab., CA (United States)

    1994-11-01

    Insect infestation increases the probability of aflatoxin contamination in pistachio nuts. A non-destructive test is currently not available to determine the insect content of pistachio nuts. This paper presents the use of film X-ray images of various types of pistachio nuts to assess the possibility of machine recognition of insect infested nuts. Histogram parameters of four derived images are used in discriminant functions to select insect infested nuts from specific processing streams.

  1. Single Photon X-Ray Imaging with Si- and CdTe-Sensors

    CERN Document Server

    Fischer, P; Krimmel, S; Krüger, H; Lindner, Manfred; Löcker, M; Sato, G; Takahashi, T; Watanabe, S; Wermes, N

    2002-01-01

    Studies of a single photon counting hybrid pixel detector for X-ray imaging applications are presented. A silicon- and a CdTe-sensor were bump bonded onto the MPEC pixel readout chip and could be successfully operated. A new USB based readout system was used for data acquisition. Measurements of the performance on the latest MPEC chip and imaging characterization of the sensors are presented.

  2. Machine recognition of navel orange worm damage in x-ray images of pistachio nuts

    Science.gov (United States)

    Keagy, Pamela M.; Parvin, Bahram; Schatzki, Thomas F.

    1995-01-01

    Insect infestation increases the probability of aflatoxin contamination in pistachio nuts. A non- destructive test is currently not available to determine the insect content of pistachio nuts. This paper uses film X-ray images of various types of pistachio nuts to assess the possibility of machine recognition of insect infested nuts. Histogram parameters of four derived images are used in discriminant functions to select insect infested nuts from specific processing streams.

  3. Synchrotron radiation phase-contrast X-ray CT imaging of acupuncture points

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Dongming; Yan, Xiaohui; Zhang, Xinyi [Fudan University, Synchrotron Radiation Research Center, State Key Laboratory of Surface Physics and Department of Physics, Shanghai (China); Liu, Chenglin [Physics Department of Yancheng Teachers' College, Yancheng (China); Dang, Ruishan [The Second Military Medical University, Shanghai (China); Xiao, Tiqiao [Chinese Academy of Sciences, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Shanghai (China); Zhu, Peiping [Chinese Academy of Sciences, Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Beijing (China)

    2011-08-15

    Three-dimensional (3D) topographic structures of acupuncture points were investigated by using synchrotron radiation in-line X-ray phase contrast computerized tomography. Two acupuncture points, named Zhongji (RN3) and Zusanli (ST36), were studied. We found an accumulation of microvessels at each acupuncture point region. Images of the tissues surrounding the acupuncture points do not show such kinds of structure. This is the first time that 3D images have revealed the specific structures of acupuncture points. (orig.)

  4. Using X-ray imaging to study thermal-induced changes in food

    DEFF Research Database (Denmark)

    Nielsen, Mikkel Schou; Miklos, Rikke; Lametsch, René

    The food quality in many food processes relies greatly on the structural changes that take place during heating or freezing of the food product. So far, it has only been possible to study these changes indirectly but recent new Xray imaging modalities allow for direct visualization. We present...... preliminary results of structural changes by heating of bovine meat and freezing of berries inspected with X-ray phase-contrast and dark-field imaging....

  5. Prototyping a Global Soft X-Ray Imaging Instrument for Heliophysics, Planetary Science, and Astrophysics Science

    Science.gov (United States)

    Collier, M. R.; Porter, F. S.; Sibeck, D. G.; Carter, J. A.; Chiao, M. P.; Chornay, D. J.; Cravens, T.; Galeazzi, M.; Keller, J. W.; Koutroumpa, D.; Kuntz, K.; Read, A. M.; Robertson, I. P.; Sembay, S.; Snowden, S.; Thomas, N.

    2012-01-01

    We describe current progress in the development of a prototype wide field-of-view soft X-ray imager that employs Lobstereye optics and targets heliophysics, planetary, and astrophysics science. The prototype will provide proof-of-concept for a future flight instrument capable of imaging the entire dayside magnetosheath from outside the magnetosphere. Such an instrument was proposed for the ESA AXIOM mission.

  6. Performance characteristics of mobile MOSFET dosimeter for kilovoltage X-rays used in image guided radiotherapy

    Directory of Open Access Journals (Sweden)

    A Sathish Kumar

    2015-01-01

    Full Text Available The main objective of this study was to investigate the characteristics of metal oxide semiconductor field effect transistor (MOSFET dosimeter for kilovoltage (kV X-ray beams in order to perform the in vivo dosimetry during image guidance in radiotherapy. The performance characteristics of high sensitivity MOSFET dosimeters were investigated for 80, 90, 100, 110, 120, and 125 kV X-ray beams used for imaging in radiotherapy. This study was performed using Clinac 2100 C/D medical electron linear accelerator with on-board imaging and kV cone beam computed tomography system. The characteristics studied in this work include energy dependence, angular dependence, and linearity. The X-ray beam outputs were measured as per American Association of Physicists in Medicine (AAPM TG 61 recommendations using PTW parallel plate (PP ionization chamber, which was calibrated in terms of air kerma (Nk by the National Standard Laboratory. The MOSFET dosimeters were calibrated against the PP ionization chamber for all the kV X-ray beams and the calibration coefficient was found to be 0.11 cGy/mV with a standard deviation of about ±1%. The response of MOSFET was found to be energy independent for the kV X-ray energies used in this study. The response of the MOSFET dosimeter was also found independent of angle of incidence for the gantry angles in the range of 0° to 360° in-air as well as at 3 cm depth in tissue equivalent phantom.

  7. High-speed X-ray imaging pixel array detector for synchrotron bunch isolation

    Energy Technology Data Exchange (ETDEWEB)

    Philipp, Hugh T., E-mail: htp2@cornell.edu; Tate, Mark W.; Purohit, Prafull; Shanks, Katherine S.; Weiss, Joel T. [Cornell University, Ithaca, NY 14853 (United States); Gruner, Sol M. [Cornell University, Ithaca, NY 14853 (United States); Cornell University, Ithaca, NY 14853 (United States)

    2016-01-28

    A high-speed pixel array detector for time-resolved X-ray imaging at synchrotrons has been developed. The ability to isolate single synchrotron bunches makes it ideal for time-resolved dynamical studies. A wide-dynamic-range imaging X-ray detector designed for recording successive frames at rates up to 10 MHz is described. X-ray imaging with frame rates of up to 6.5 MHz have been experimentally verified. The pixel design allows for up to 8–12 frames to be stored internally at high speed before readout, which occurs at a 1 kHz frame rate. An additional mode of operation allows the integration capacitors to be re-addressed repeatedly before readout which can enhance the signal-to-noise ratio of cyclical processes. This detector, along with modern storage ring sources which provide short (10–100 ps) and intense X-ray pulses at megahertz rates, opens new avenues for the study of rapid structural changes in materials. The detector consists of hybridized modules, each of which is comprised of a 500 µm-thick silicon X-ray sensor solder bump-bonded, pixel by pixel, to an application-specific integrated circuit. The format of each module is 128 × 128 pixels with a pixel pitch of 150 µm. In the prototype detector described here, the three-side buttable modules are tiled in a 3 × 2 array with a full format of 256 × 384 pixels. The characteristics, operation, testing and application of the detector are detailed.

  8. Fabricating sub-collimating grids for an x-ray solar imaging spectrometer using LIGA techniques

    Energy Technology Data Exchange (ETDEWEB)

    Brennen, R.A.; Hecht, M.H.; Wiberg, D.V. [Jet Propulsion Lab., Pasadena, CA (United States)] [and others

    1997-04-01

    The HESSI mission proposes to perform high resolution imaging and spectroscopy observations in the soft X-ray, hard X-ray, and gamma-ray regimes, with finer angular resolution (nearly 2 arcseconds) and finer energy resolution (approximately 1 keV) than has been previously possible. This combination of imaging and spectroscopy is achieved with a set of Rotating Modulation Collimators placed in front of an array of cooled germanium and silicon detectors. A set of 12 bi-grid collimators, each of which consists of a pair of identically pitched, widely-separated grids, is used to provide the imaging. Each grid consists of a planar array of equally-spaced, parallel, X-ray opaque slats separated by X-ray transparent slits. If the slits of each grid are parallel to each other and the pitch is identical for the two grids, then the transmission through the grid pair depends on the direction of incidence of the incoming X-rays. For slits and slats of equal width, the transmission varies between zero and 50% depending on whether the shadows of the slats in the top grid fall on the slits or slats of the lower grid. A complete transmission cycle from zero to 50% and back to zero corresponds to a change in source direction that is given by p/L, where L is the separation between the grids. The authors describe a deep etch lithography technique developed to fabricate the grids which have pitches below 100 {micro}m. They use a free standing sheet of PMMA as a base for the process, and use the ALS facility to perform the exposures of the PMMA.

  9. Micro X-ray Fluorescence Imaging in a Tabletop Full Field-X-ray Fluorescence Instrument and in a Full Field-Particle Induced X-ray Emission End Station.

    Science.gov (United States)

    Romano, Francesco Paolo; Caliri, Claudia; Cosentino, Luigi; Gammino, Santo; Mascali, David; Pappalardo, Lighea; Rizzo, Francesca; Scharf, Oliver; Santos, Hellen Cristine

    2016-10-08

    A full field-X-ray camera (FF-XRC) was developed for performing the simultaneous mapping of chemical elements with a high lateral resolution. The device is based on a conventional CCD detector coupled to a straight shaped polycapillary. Samples are illuminated at once with a broad primary beam that can consist of X-rays or charged particles in two different analytical setups. The characteristic photons induced in the samples are guided by the polycapillary to the detector allowing the elemental imaging without the need for scanning. A single photon counting detection operated in a multiframe acquisition mode and a processing algorithm developed for event hitting reconstruction have enabled one to use the CCD as a high energy resolution X-ray detector. A novel software with a graphical user interface (GUI) programmed in Matlab allows full control of the device and the real-time imaging with a region-of-interest (ROI) method. At the end of the measurement, the software produces spectra for each of the pixels in the detector allowing the application of a least-squares fitting with external analytical tools. The FF-XRC is very compact and can be installed in different experimental setups. This work shows the potentialities of the instrument in both a full field-micro X-ray fluorescence (FF-MXRF) tabletop device and in a full field-micro particle induced X-ray emission (FF-MPIXE) end-station operated with an external proton beam. Some examples of applications are given as well.

  10. Simulation study of spatial resolution in phase-contrast X-ray imaging with Takagi-Taupin equation

    CERN Document Server

    Koyama, I

    2003-01-01

    To evaluate attainable spatial resolution of phase-contrast X-ray imaging using an LLL X-ray interferometer with a thin crystal wafer, a computer simulation study with Takagi-Taupin equation was performed. Modulation transfer function of the wafer for X-ray phase was evaluated. For a polyester film whose thickness is 0.1 mm, it was concluded that the spatial resolution can be improved up to 3 mu m by thinning the wafer, under our experimental condition.

  11. Megavoltage X-Ray Imaging Based on Cerenkov Effect: A New Application of Optical Fibres to Radiation Therapy

    Directory of Open Access Journals (Sweden)

    A. Teymurazyan

    2012-01-01

    Full Text Available A Monte Carlo simulation was used to study imaging and dosimetric characteristics of a novel design of megavoltage (MV X-ray detectors for radiotherapy applications. The new design uses Cerenkov effect to convert X-ray energy absorbed in optical fibres into light for MV X-ray imaging. The proposed detector consists of a matrix of optical fibres aligned with the incident X rays and coupled to an active matrix flat-panel imager (AMFPI for image readout. Properties, such as modulation transfer function, detection quantum efficiency (DQE, and energy response of the detector, were investigated. It has been shown that the proposed detector can have a zero-frequency DQE more than an order of magnitude higher than that of current electronic portal imaging device (EPID systems and yet a spatial resolution comparable to that of video-based EPIDs. The proposed detector is also less sensitive to scattered X rays from patients than current EPIDs.

  12. Terahertz ISAR and x-ray imaging of wind turbine blade structures

    Science.gov (United States)

    Martin, Robert; Baird, Christopher S.; Giles, Robert H.; Niezrecki, Christopher

    2016-04-01

    During the manufacture of wind turbine blades, internal defects can form which negatively affect their structural integrity and may lead to premature failure. The purpose of this research was to conduct preliminary testing of nondestructive evaluation techniques that have the potential to scale up to larger areas. The techniques investigated were: Terahertz frequency fully-polarimetric inverse synthetic aperture radar (ISAR), and x-ray imaging. The terahertz ISAR technique employed standard polarimetric radar cross-section processing, and additionally applied an optimized polarimetry transformation known as the Euler transformation. Also, image back-rotation and compositing algorithms were used to combine multiple ISAR images into a single image to aid in defect detection. ISAR data were collected using a frequency modulated continuous wave 100 GHz radar system. The x-ray technique utilized a commercial airport cargo x-ray scanner. Multiple fiberglass samples with defects representative of manufacturing wind turbine blade defects were investigated using each of the techniques. Out-of-plane defects and resin dry patches were the primary defects of interest in these samples. Images were created of each sample using each of the techniques. Comparing these images with defect diagrams of the samples indicated that these techniques could effectively indicate the presence of certain defects.

  13. Fractional Brownian Motion and Geodesic Rao Distance for Bone X-ray Image Characterization.

    Science.gov (United States)

    El Hassouni, Mohammed; Tafraouti, Abdessamad; Toumi, Hechmi; Lespessailles, Eric; Jennane, Rachid

    2016-10-19

    Osteoporosis diagnosis has attracted particular attention in recent decades. Textured images from the microarchitecture of osteoporotic and healthy subjects show a high degree of similarity, increasing the difficulty of classifying such textures. Thus, the evaluation of osteoporosis from bone X-ray images presents a major challenge for pattern recognition and medical applications. The purpose of this paper is to use the fractional Brownian motion (fBm) model and the Probability Density Function (PDF) of its increments to compute a similarity measure with the Rao geodesic distance to classify trabecular bone X-ray images. When evaluated on synthetic fBm images (test vectors) with the well-known Hurst parameter H, the proposed method met our expectations in that a good classification of the synthetic images was achieved. A clinical study was conducted on textured bone X-ray images from two different female populations of osteoporotic patients (fracture cases) and control subjects. Using the proposed method, an Area Under Curve (AUC) rate of 97% was achieved.

  14. Development Status of Adjustable X-ray Optics with 0.5 Arcsec Imaging for the X-ray Surveyor Mission Concept

    Science.gov (United States)

    Reid, Paul B.; Allured, Ryan; ben-Ami, Sagi; Cotroneo, Vincenzo; Schwartz, Daniel A.; Tananbaum, Harvey; Vikhlinin, Alexey; Trolier-McKinstry, Susan; Wallace, Margeaux L.; Jackson, Tom

    2016-04-01

    The X-ray Surveyor mission concept is designed as a successor to the Chandra X-ray Observatory. As currently envisioned, it will have as much as 30-50 times the collecting area of Chandra with the same 0.5 arcsec imaging resolution. This combination of telescope area and imaging resolution, along with a detector suite for imaging and dispersive and non-dispersive imaging spectroscopy, will enable a wide range of astrophysical observations. These observations will include studies of the growth of large scale structure, early black holes and the growth of SMBHs, and high resolution spectroscopy with arcsec resolution, among many others. We describe the development of adjustable grazing incidence X-ray optics, a potential technology for the high resolution, thin, lightweight mirrors. We discuss recent advancements including the demonstration of deterministic figure correction via the use of the adjusters, the successful demonstration of integrating control electronics directly on the actuator cells to enable row-column addressing, and discuss the feasibility of on-orbit piezoelectric performance and figure monitoring via integrated semiconductor strain gauges. We also present the telescope point design and progress in determining the telescope thermal sensitivities and achieving alignment and mounting requirements.

  15. X-ray Scatter Imaging of Hepatocellular Carcinoma in a Mouse Model Using Nanoparticle Contrast Agents

    Science.gov (United States)

    Rand, Danielle; Derdak, Zoltan; Carlson, Rolf; Wands, Jack R.; Rose-Petruck, Christoph

    2015-10-01

    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is almost uniformly fatal. Current methods of detection include ultrasound examination and imaging by CT scan or MRI; however, these techniques are problematic in terms of sensitivity and specificity, and the detection of early tumors (contrast agents can be detected using SFHI. We also demonstrate that directed targeting and SFHI of HCC tumors in a mouse model is possible through the use of HCC-specific antibodies. The enhanced sensitivity of SFHI relative to currently available techniques enables the x-ray imaging of tumors that are just a few millimeters in diameter and substantially reduces the amount of nanoparticle contrast agent required for intravenous injection relative to absorption-based x-ray imaging.

  16. Diffraction imaging for in-situ characterization of double-crystal x-ray monochromators

    CERN Document Server

    Stoupin, Stanislav; Heald, Steve M; Brewe, Dale; Meron, Mati

    2015-01-01

    Imaging of the Bragg reflected x-ray beam is proposed and validated as an in-situ method for characterization of performance of double-crystal monochromators under the heat load of intense synchrotron radiation. A sequence of images is collected at different angular positions on the reflectivity curve of the second crystal and analyzed. The method provides rapid evaluation of the wavefront of the exit beam, which relates to local misorientation of the crystal planes along the beam footprint on the thermally distorted first crystal. The measured misorientation can be directly compared to results of finite element analysis. The imaging method offers an additional insight on the local intrinsic crystal quality over the footprint of the incident x-ray beam.

  17. Elemental distribution images in prostate samples by X-ray fluorescence microtomography

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, G.R. [Non-destructive Testing, Corrosion and Welding Laboratory, PEMM/COPPE/UFRJ, Rio de Janeiro (Brazil); Rocha, H.S. [Nuclear Instrumentation Laboratory, PEN/COPPE/UFRJ, P.O. Box 68509, 21.941-972, Rio de Janeiro (Brazil); Anjos, M.J. [Physics Institute-Stated University of Rio de Janeiro, Rio de Janeiro (Brazil); Lima, I. [Nuclear Instrumentation Laboratory, PEN/COPPE/UFRJ, P.O. Box 68509, 21.941-972, Rio de Janeiro (Brazil); Lopes, R.T., E-mail: ricardo@lin.ufrj.br [Nuclear Instrumentation Laboratory, PEN/COPPE/UFRJ, P.O. Box 68509, 21.941-972, Rio de Janeiro (Brazil)

    2012-07-15

    An X-ray transmission microtomography (CT) system combined with an X-ray fluorescence microtomography (XRF{mu}CT) system was implemented in the Brazilian Synchrotron Light Laboratory (LNLS), in order to determine the elemental distribution in prostate samples aiming at establishing a correlation between the concentration of some elements and the characteristics and pathology of the tissues. The CT images were reconstructed using a filtered-back projection algorithm and the XRF{mu}CT images were reconstructed using a filtered-back projection algorithm with absorption corrections. - Highlights: Black-Right-Pointing-Pointer In this study we evaluated prostate tissues by microtomography imaging techniques. Black-Right-Pointing-Pointer The elemental distribution of iron, copper and zinc was obtained in each sample. Black-Right-Pointing-Pointer The great advantage of this technique is the visualization in three-dimension. Black-Right-Pointing-Pointer The elemental distribution visualization was obtained without damaging the material.

  18. Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution

    Science.gov (United States)

    Yan, Hanfei; Nazaretski, Evgeny; Lauer, Kenneth; Huang, Xiaojing; Wagner, Ulrich; Rau, Christoph; Yusuf, Mohammed; Robinson, Ian; Kalbfleisch, Sebastian; Li, Li; Bouet, Nathalie; Zhou, Juan; Conley, Ray; Chu, Yong S.

    2016-02-01

    We developed a scanning hard x-ray microscope using a new class of x-ray nano-focusing optic called a multilayer Laue lens and imaged a chromosome with nanoscale spatial resolution. The combination of the hard x-ray’s superior penetration power, high sensitivity to elemental composition, high spatial-resolution and quantitative analysis creates a unique tool with capabilities that other microscopy techniques cannot provide. Using this microscope, we simultaneously obtained absorption-, phase-, and fluorescence-contrast images of Pt-stained human chromosome samples. The high spatial-resolution of the microscope and its multi-modality imaging capabilities enabled us to observe the internal ultra-structures of a thick chromosome without sectioning it.

  19. Compound focusing mirror and X-ray waveguide optics for coherent imaging and nano-diffraction.

    Science.gov (United States)

    Salditt, Tim; Osterhoff, Markus; Krenkel, Martin; Wilke, Robin N; Priebe, Marius; Bartels, Matthias; Kalbfleisch, Sebastian; Sprung, Michael

    2015-07-01

    A compound optical system for coherent focusing and imaging at the nanoscale is reported, realised by high-gain fixed-curvature elliptical mirrors in combination with X-ray waveguide optics or different cleaning apertures. The key optical concepts are illustrated, as implemented at the Göttingen Instrument for Nano-Imaging with X-rays (GINIX), installed at the P10 coherence beamline of the PETRA III storage ring at DESY, Hamburg, and examples for typical applications in biological imaging are given. Characteristic beam configurations with the recently achieved values are also described, meeting the different requirements of the applications, such as spot size, coherence or bandwidth. The emphasis of this work is on the different beam shaping, filtering and characterization methods.

  20. Study of X-ray Kirkpatrick-Baez imaging with single layer

    Institute of Scientific and Technical Information of China (English)

    Baozhong Mu; Zhanshan Wang; Shengzhen Yi; Xin Wang; Shengling Huang; Jingtao Zhu; Chengchao Huang

    2009-01-01

    The X-ray Kirkpatrick-Baez(KB)imaging experiment with single layer is implemented.Based on the astigmatism aberration and residual geometric aberration of a single mirror.a KB system with 16x mean magnification and approxinlately 0.45° grazing incidence angle is designed.The mirrors are deposited with an Ir layer of 20-nm thickness.Au grids backlit by X-ray tube of 8 keV are imaged via the KB system on scintillator charge-coupled device(CCD).In the ±80 μm field,resolutions of less than 5 μm are measured.The result is in good agreenmnt with the simulated imaging.

  1. Photon Counting Energy Dispersive Detector Arrays for X-ray Imaging.

    Science.gov (United States)

    Iwanczyk, Jan S; Nygård, Einar; Meirav, Oded; Arenson, Jerry; Barber, William C; Hartsough, Neal E; Malakhov, Nail; Wessel, Jan C

    2009-01-01

    The development of an innovative detector technology for photon-counting in X-ray imaging is reported. This new generation of detectors, based on pixellated cadmium telluride (CdTe) and cadmium zinc telluride (CZT) detector arrays electrically connected to application specific integrated circuits (ASICs) for readout, will produce fast and highly efficient photon-counting and energy-dispersive X-ray imaging. There are a number of applications that can greatly benefit from these novel imagers including mammography, planar radiography, and computed tomography (CT). Systems based on this new detector technology can provide compositional analysis of tissue through spectroscopic X-ray imaging, significantly improve overall image quality, and may significantly reduce X-ray dose to the patient. A very high X-ray flux is utilized in many of these applications. For example, CT scanners can produce ~100 Mphotons/mm(2)/s in the unattenuated beam. High flux is required in order to collect sufficient photon statistics in the measurement of the transmitted flux (attenuated beam) during the very short time frame of a CT scan. This high count rate combined with a need for high detection efficiency requires the development of detector structures that can provide a response signal much faster than the transit time of carriers over the whole detector thickness. We have developed CdTe and CZT detector array structures which are 3 mm thick with 16×16 pixels and a 1 mm pixel pitch. These structures, in the two different implementations presented here, utilize either a small pixel effect or a drift phenomenon. An energy resolution of 4.75% at 122 keV has been obtained with a 30 ns peaking time using discrete electronics and a (57)Co source. An output rate of 6×10(6) counts per second per individual pixel has been obtained with our ASIC readout electronics and a clinical CT X-ray tube. Additionally, the first clinical CT images, taken with several of our prototype photon-counting and

  2. Laboratory-size three-dimensional x-ray microscope with Wolter type I mirror optics and an electron-impact water window x-ray source.

    Science.gov (United States)

    Ohsuka, Shinji; Ohba, Akira; Onoda, Shinobu; Nakamoto, Katsuhiro; Nakano, Tomoyasu; Miyoshi, Motosuke; Soda, Keita; Hamakubo, Takao

    2014-09-01

    We constructed a laboratory-size three-dimensional water window x-ray microscope that combines wide-field transmission x-ray microscopy with tomographic reconstruction techniques, and observed bio-medical samples to evaluate its applicability to life science research fields. It consists of a condenser and an objective grazing incidence Wolter type I mirror, an electron-impact type oxygen Kα x-ray source, and a back-illuminated CCD for x-ray imaging. A spatial resolution limit of around 1.0 line pairs per micrometer was obtained for two-dimensional transmission images, and 1-μm scale three-dimensional fine structures were resolved.

  3. Single-Grid-Pair Fourier Telescope for Imaging in Hard-X Rays and gamma Rays

    Science.gov (United States)

    Campbell, Jonathan

    2008-01-01

    This instrument, a proposed Fourier telescope for imaging in hard-x rays and gamma rays, would contain only one pair of grids made of an appropriate radiation-absorpting/ scattering material, in contradistinction to multiple pairs of such as grids in prior Fourier x- and gamma-ray telescopes. This instrument would also include a relatively coarse gridlike image detector appropriate to the radiant flux to be imaged. Notwithstanding the smaller number of grids and the relative coarseness of the imaging detector, the images produced by the proposed instrument would be of higher quality.

  4. High-resolution 3D X-ray imaging of intracranial nitinol stents

    Energy Technology Data Exchange (ETDEWEB)

    Snoeren, Rudolph M.; With, Peter H.N. de [Eindhoven University of Technology (TU/e), Faculty Electrical Engineering, Signal Processing Systems group (SPS), Eindhoven (Netherlands); Soederman, Michael [Karolinska University Hospital, Department of Neuroradiology, Stockholm (Sweden); Kroon, Johannes N.; Roijers, Ruben B.; Babic, Drazenko [Philips Healthcare, Best (Netherlands)

    2012-02-15

    To assess an optimized 3D imaging protocol for intracranial nitinol stents in 3D C-arm flat detector imaging. For this purpose, an image quality simulation and an in vitro study was carried out. Nitinol stents of various brands were placed inside an anthropomorphic head phantom, using iodine contrast. Experiments with objects were preceded by image quality and dose simulations. We varied X-ray imaging parameters in a commercially interventional X-ray system to set 3D image quality in the contrast-noise-sharpness space. Beam quality was varied to evaluate contrast of the stents while keeping absorbed dose below recommended values. Two detector formats were used, paired with an appropriate pixel size and X-ray focus size. Zoomed reconstructions were carried out and snapshot images acquired. High contrast spatial resolution was assessed with a CT phantom. We found an optimal protocol for imaging intracranial nitinol stents. Contrast resolution was optimized for nickel-titanium-containing stents. A high spatial resolution larger than 2.1 lp/mm allows struts to be visualized. We obtained images of stents of various brands and a representative set of images is shown. Independent of the make, struts can be imaged with virtually continuous strokes. Measured absorbed doses are shown to be lower than 50 mGy Computed Tomography Dose Index (CTDI). By balancing the modulation transfer of the imaging components and tuning the high-contrast imaging capabilities, we have shown that thin nitinol stent wires can be reconstructed with high contrast-to-noise ratio and good detail, while keeping radiation doses within recommended values. Experimental results compare well with imaging simulations. (orig.)

  5. High Spectral Resolution, High Cadence, Imaging X-Ray Microcalorimeters for Solar Physics

    Science.gov (United States)

    Bandler, Simon R.; Bailey, Catherine N.; Bookbinder, Jay A.; DeLuca, Edward E.; Chervenak, Jay A.; Eckart, Megan E.; Finkbeiner, Fred M.; Kelley, Daniel P.; Kelley, Richard L.; Kilbourne, Caroline A.; Porter, Frederick S.; Sadleir, Jack E.; Smith, Stephen J.; Smith, Randall K.

    2010-01-01

    High spectral resolution, high cadence, imaging x-ray spectroscopy has the potential to revolutionize the study of the solar corona. To that end we have been developing transition-edge-sensor (TES) based x-ray micro calorimeter arrays for future solar physics missions where imaging and high energy resolution spectroscopy will enable previously impossible studies of the dynamics and energetics of the solar corona. The characteristics of these x-ray microcalorimeters are significantly different from conventional micro calorimeters developed for astrophysics because they need to accommodate much higher count rates (300-1000 cps) while maintaining high energy resolution of less than 4 eV FWHM in the X-ray energy band of 0.2-10 keV. The other main difference is a smaller pixel size (less than 75 x 75 square microns) than is typical for x-ray micro calorimeters in order to provide angular resolution less than 1 arcsecond. We have achieved at energy resolution of 2.15 eV at 6 keV in a pixel with a 12 x 12 square micron TES sensor and 34 x 34 x 9.1 micron gold absorber, and a resolution of 2.30 eV at 6 keV in a pixel with a 35 x 35 micron TES and a 57 x 57 x 9.1 micron gold absorber. This performance has been achieved in pixels that are fabricated directly onto solid substrates, ie. they are not supported by silicon nitride membranes. We present the results from these detectors, the expected performance at high count-rates, and prospects for the use of this technology for future Solar missions.

  6. Development of x-ray imaging technique for liquid screening at airport

    Energy Technology Data Exchange (ETDEWEB)

    Sulaiman, Nurhani binti, E-mail: nhani.sulaiman@gmail.com; Srisatit, Somyot, E-mail: somyot.s@chula.ac.th [Department of Nuclear Engineering, Faculty of Engineering, Chulalongkorn University, Phayathai Rd., Patumwan, Bangkok 10330 (Thailand)

    2016-01-22

    X-ray imaging technology is a viable option to recognize flammable liquids for the purposes of aviation security. In this study, an X-ray imaging technology was developed whereby, the image viewing system was built with the use of a digital camera coupled with a gadolinium oxysulfide (GOS) fluorescent screen. The camera was equipped with a software for remote control setting of the camera via a USB cable which allows the images to be captured. The image was analysed to determine the average grey level using a software designed by Microsoft Visual Basic 6.0. The data was obtained for various densities of liquid thickness of 4.5 cm, 6.0 cm and 7.5 cm respectively for X-ray energies ranging from 70 to 200 kVp. In order to verify the reliability of the constructed calibration data, the system was tested with a few types of unknown liquids. The developed system could be conveniently employed for security screening in order to discriminate between a threat and an innocuous liquid.

  7. X-ray phase contrast imaging of calcified tissue and biomaterial structure in bioreactor engineered tissues.

    Science.gov (United States)

    Appel, Alyssa A; Larson, Jeffery C; Garson, Alfred B; Guan, Huifeng; Zhong, Zhong; Nguyen, Bao-Ngoc B; Fisher, John P; Anastasio, Mark A; Brey, Eric M

    2015-03-01

    Tissues engineered in bioreactor systems have been used clinically to replace damaged tissues and organs. In addition, these systems are under continued development for many tissue engineering applications. The ability to quantitatively assess material structure and tissue formation is critical for evaluating bioreactor efficacy and for preimplantation assessment of tissue quality. Techniques that allow for the nondestructive and longitudinal monitoring of large engineered tissues within the bioreactor systems will be essential for the translation of these strategies to viable clinical therapies. X-ray Phase Contrast (XPC) imaging techniques have shown tremendous promise for a number of biomedical applications owing to their ability to provide image contrast based on multiple X-ray properties, including absorption, refraction, and scatter. In this research, mesenchymal stem cell-seeded alginate hydrogels were prepared and cultured under osteogenic conditions in a perfusion bioreactor. The constructs were imaged at various time points using XPC microcomputed tomography (µCT). Imaging was performed with systems using both synchrotron- and tube-based X-ray sources. XPC µCT allowed for simultaneous three-dimensional (3D) quantification of hydrogel size and mineralization, as well as spatial information on hydrogel structure and mineralization. Samples were processed for histological evaluation and XPC showed similar features to histology and quantitative analysis consistent with the histomorphometry. These results provide evidence of the significant potential of techniques based on XPC for noninvasive 3D imaging engineered tissues grown in bioreactors.

  8. Processing of x-ray image in the intelligent setting system for fracture

    Science.gov (United States)

    Zheng, Wei; Zhang, Liyong; Liu, Sijiu; Yu, Zhiguo

    2006-11-01

    Intelligent setting system based on biomechanics and bone fracture therapy can accomplish micro-wound, intelligence and high efficiency of fracture setting. X-ray images grabbed by C-shape-arm X-ray machine supply the most key data for intelligent setting. Processing, analysis and transmission security of the image is the core in the system. According to characteristics being shown in three dimensions gray distribution figure and frequency spectrum of the image, histogram equalization in space domain and homomorphic filtering in frequency domain are separately proposed to enhance contrast and sharpness. On the foundation of mining orthopedics experts experience knowledge, setting for femoral-neck fracture is turned into three in-continuous operations that are reflected in the X-ray images through nine points, six lines, two angles and one distance and that are able to be implemented by mechanical manipulator and control device in the system. Master-slave reference frame is put forward to supply a stable reference standard to calculate parameters. Encryption method based on chaos dynamics system is brought forward to ensure image information security in the process of telemedicine intelligent setting for fracture. Clinic experience proved that the system can help orthopedists to correctly and reliably complete setting for bone fracture.

  9. X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

    Energy Technology Data Exchange (ETDEWEB)

    Kunisada, Toshiyuki [Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan)], E-mail: toshi-kunisada@umin.ac.jp; Shimao, Daisuke [Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-2394 (Japan); Sugiyama, Hiroshi [Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Ibaraki 305-0801 (Japan); Takeda, Ken; Ozaki, Toshifumi [Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Ando, Masami [Research Institute for Science and Technology, Tokyo University of Science, Chiba 278-8510 (Japan)

    2008-12-15

    Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis.

  10. The protoMIRAX Hard X-ray Imaging Balloon Experiment

    CERN Document Server

    Braga, João; Avila, Manuel A C; Penacchioni, Ana V; Sacahui, J Rodrigo; Santiago, Valdivino A de; Mattiello-Francisco, Fátima; Strauss, Cesar; Fialho, Márcio A A

    2015-01-01

    The protoMIRAX hard X-ray imaging telescope is a balloon-borne experiment developed as a pathfinder for the MIRAX satellite mission. The experiment consists essentially in a coded-aperture hard X-ray (30-200 keV) imager with a square array (13$\\times$13) of 2mm-thick planar CZT detectors with a total area of 169 cm$^2$. The total, fully-coded field-of-view is $21^{\\circ}\\times 21^{\\circ}$ and the angular resolution is 1$^{\\circ}$43'. In this paper we describe the protoMIRAX instrument and all the subsystems of its balloon gondola, and we show simulated results of the instrument performance. The main objective of protoMIRAX is to carry out imaging spectroscopy of selected bright sources to demonstrate the performance of a prototype of the MIRAX hard X-ray imager. Detailed background and imaging simulations have been performed for protoMIRAX balloon flights. The 3$\\sigma$ sensitivity for the 30-200 keV range is ~1.9 $\\times$ 10$^{-5}$ photons cm$^{-2}$ s$^{-1}$ for an integration time of 8 hs at an atmospheric ...

  11. X-ray Phase Contrast Imaging of Calcified Tissue and Biomaterial Structure in Bioreactor Engineered Tissues

    Energy Technology Data Exchange (ETDEWEB)

    Appel, Alyssa A. [Illinois Inst. of Technology, Chicago, IL (United States); Edward Hines Jr. VA Hospital, IL (United States); Larson, Jeffery C. [Illinois Inst. of Technology, Chicago, IL (United States); Edward Hines Jr. VA Hospital, IL (United States); Garson, III, Alfred B. [George Washington Univ., Washington, DC (United States); Guan, Huifeng [George Washington Univ., Washington, DC (United States); Zhong, Zhong [Brookhaven National Lab. (BNL), Upton, NY (United States); Nguyen, Bao-Ngoc [Univ. of Maryland, College Park, MD (United States); Fisher, John P. [Univ. of Maryland, College Park, MD (United States); Anastasio, Mark A. [George Washington Univ., Washington, DC (United States); Brey, Eric M. [Illinois Inst. of Technology, Chicago, IL (United States); Edward Hines Jr. VA Hospital, IL (United States)

    2014-11-04

    Tissues engineered in bioreactor systems have been used clinically to replace damaged tissues and organs. In addition, these systems are under continued development for many tissue engineering applications. The ability to quantitatively assess material structure and tissue formation is critical for evaluating bioreactor efficacy and for preimplantation assessment of tissue quality. These techniques allow for the nondestructive and longitudinal monitoring of large engineered tissues within the bioreactor systems and will be essential for the translation of these strategies to viable clinical therapies. X-ray Phase Contrast (XPC) imaging techniques have shown tremendous promise for a number of biomedical applications owing to their ability to provide image contrast based on multiple X-ray properties, including absorption, refraction, and scatter. In this research, mesenchymal stem cell-seeded alginate hydrogels were prepared and cultured under osteogenic conditions in a perfusion bioreactor. The constructs were imaged at various time points using XPC microcomputed tomography (µCT). Imaging was performed with systems using both synchrotron- and tube-based X-ray sources. XPC µCT allowed for simultaneous three-dimensional (3D) quantification of hydrogel size and mineralization, as well as spatial information on hydrogel structure and mineralization. Samples were processed for histological evaluation and XPC showed similar features to histology and quantitative analysis consistent with the histomorphometry. Furthermore, these results provide evidence of the significant potential of techniques based on XPC for noninvasive 3D imaging engineered tissues grown in bioreactors.

  12. Tissue Equivalent Phantom Design for Characterization of a Coherent Scatter X-ray Imaging System

    Science.gov (United States)

    Albanese, Kathryn Elizabeth

    Scatter in medical imaging is typically cast off as image-related noise that detracts from meaningful diagnosis. It is therefore typically rejected or removed from medical images. However, it has been found that every material, including cancerous tissue, has a unique X-ray coherent scatter signature that can be used to identify the material or tissue. Such scatter-based tissue-identification provides the advantage of locating and identifying particular materials over conventional anatomical imaging through X-ray radiography. A coded aperture X-ray coherent scatter spectral imaging system has been developed in our group to classify different tissue types based on their unique scatter signatures. Previous experiments using our prototype have demonstrated that the depth-resolved coherent scatter spectral imaging system (CACSSI) can discriminate healthy and cancerous tissue present in the path of a non-destructive x-ray beam. A key to the successful optimization of CACSSI as a clinical imaging method is to obtain anatomically accurate phantoms of the human body. This thesis describes the development and fabrication of 3D printed anatomical scatter phantoms of the breast and lung. The purpose of this work is to accurately model different breast geometries using a tissue equivalent phantom, and to classify these tissues in a coherent x-ray scatter imaging system. Tissue-equivalent anatomical phantoms were designed to assess the capability of the CACSSI system to classify different types of breast tissue (adipose, fibroglandular, malignant). These phantoms were 3D printed based on DICOM data obtained from CT scans of prone breasts. The phantoms were tested through comparison of measured scatter signatures with those of adipose and fibroglandular tissue from literature. Tumors in the phantom were modeled using a variety of biological tissue including actual surgically excised benign and malignant tissue specimens. Lung based phantoms have also been printed for future

  13. Laser and Pulsed Power Electron Density Imaging Through Talbot-Lau X-ray Deflectometry

    Science.gov (United States)

    Valdivia Leiva, Maria Pia; Stutman, Dan; Stoeckl, Christian; Mileham, Chad; Begischev, Ildar; Theobald, Wolfgang; Bromage, Jake; Regan, Sean; Klein, Salee; Muñoz-Cordovez, Gonzalo; Vescovi, Milenko; Valenzuela-Villaseca, Vicente; Veloso, Felipe

    2016-10-01

    A Talbot-Lau X-ray Deflectometer was deployed using laser driven and x-pinch x-ray backlighters. The Talbot-Lau X-ray Deflectometer is an ideal electron density diagnostic for High Energy Density plasmas with the potential to simultaneously deliver x-ray refraction, attenuation, elemental composition, and scatter information from a single image with source limited resolution. Grating survival and electron density mapping was demonstrated for 10-29 J, 8-30 ps laser pulses using Cu foil targets at the Multi-TeraWatt facility. An areal electron density of 0.050 g/cm2 was obtained at the center of a fluoro-nylon fiber of 300 mm diameter with a source FWHM of 80 µm and resolution of 50 µm. Grating survival and Moiré pattern formation was demonstrated using a Cu x-pinch plasma of FWHM 27 µm, driven by the 350 kA, 350 ns Llampudken pulsed power generator. These results closely match simulations and laboratory results. It was demonstrated that the technique can detect both sharp and smooth density gradients in the range of 2x1023 to 2x1025 cm-3, thus allowing implementation of the electron density technique as a HED plasma diagnostic in both laser and pulsed power experiments U.S. DoE/NNSA and DE-NA0002955.

  14. Direct X-Ray Imaging of Transient Spin Accumulation near a Ferromagnet/Nonmagnet Interface

    Science.gov (United States)

    Chen, Zhao; Kukreja, Roopali; Bonetti, Stefano; Backes, Dirk; Kent, Andrew; Katine, Jordan; Durr, Hermann; Ohldag, Hendrik; Stohr, Joachim

    2015-03-01

    The physics of spin transport across a ferromagnet/nonmagnet interface is not well understood, even though such interfaces are common in spintronic devices. We use time-resolved x-ray spectro-microscopy to directly image transient spin accumulation in a Cu film caused by an injected spin current from an adjacent Co film. The measurement uses element-specific, circularly polarized x-rays detected via a scanning transmission x-ray microscope (STXM) in conjunction with 1.28MHz temporal modulation for remarkably increased x-ray sensitivity to spin signals. The transient moments per atom within the spin diffusion length from the interface were measured to be 8 x 10-5μB per Cu atom and 1.5 x 10-4μB per Co atom. The transient spin signal in Cu is found to be confined to states at the Fermi level, as expected, but we also observe a second peak of the same spin polarization in the spin accumulation signal that is 0.7eV higher than Fermi. The transient moments in the 28nm thick Cu layer exhibit the same spin sign as both the hybridization-induced static spins in Cu at the Cu/Co interface and the spins in the Co film. In contrast, the transient moments in the Co layer have the opposite sign, consistent with magnetization depleting from the Co polarizing layer.

  15. Nanoscale x-ray imaging of circuit features without wafer etching

    Science.gov (United States)

    Deng, Junjing; Hong, Young Pyo; Chen, Si; Nashed, Youssef S. G.; Peterka, Tom; Levi, Anthony J. F.; Damoulakis, John; Saha, Sayan; Eiles, Travis; Jacobsen, Chris

    2017-03-01

    Modern integrated circuits (ICs) employ a myriad of materials organized at nanoscale dimensions, and certain critical tolerances must be met for them to function. To understand departures from intended functionality, it is essential to examine ICs as manufactured so as to adjust design rules ideally in a nondestructive way so that imaged structures can be correlated with electrical performance. Electron microscopes can do this on thin regions or on exposed surfaces, but the required processing alters or even destroys functionality. Microscopy with multi-keV x rays provides an alternative approach with greater penetration, but the spatial resolution of x-ray imaging lenses has not allowed one to see the required detail in the latest generation of ICs. X-ray ptychography provides a way to obtain images of ICs without lens-imposed resolution limits with past work delivering 20-40-nm resolution on thinned ICs. We describe a simple model for estimating the required exposure and use it to estimate the future potential for this technique. Here we show that this approach can be used to image circuit detail through an unprocessed 300 -μ m -thick silicon wafer with sub-20-nm detail clearly resolved after mechanical polishing to 240 -μ m thickness was used to eliminate image contrast caused by Si wafer surface scratches. By using continuous x-ray scanning, massively parallel computation, and a new generation of synchrotron light sources, this should enable entire nonetched ICs to be imaged to 10-nm resolution or better while maintaining their ability to function in electrical tests.

  16. The chest X-ray image features of patients with severe SARS: a preliminary study

    Institute of Scientific and Technical Information of China (English)

    刘晋新; 唐小平; 江松峰; 陈碧华; 张烈光; 黄德扬; 黄务枝; 史红玲; 尹炽标; 陈金城

    2003-01-01

    Objective To study the chest X-ray image features of patients with severe SARS.Methods Chest X-ray image features in 36 patients with severe SARS were retrospectively analyzed. The image characteristics were compared with those of 224 patients with common SARS. Results The important chest X-ray imaging features of 36 patients with severe SARS included small patch of infiltration (n=27, 75.0%), large patch of infiltration (n=22, 61.1%), large area of lung consolidation (n=10, 27.3%), interstitial lung lesion (n=26, 72.2%), ground-glass shadow (n=28, 77.8%), irregular linear opacity (n=15, 41.7%), diffuse lung lesion (n=12, 33.3%), with single lung involved (n=9, 25.0%), and both lungs involved (n=32, 88.9%). The rates of large patch of infiltration, large area of lung consolidation, ground-glass shadow, diffuse lung lesion and involvement of both lungs in patients with severe SARS were significantly higher than those in patients with common type of SARS (all P<0.01). Out of the 11 severe SARS patients who died, nine had large area of ground-glass shadow with air bronchogram in both lungs before death.Conclusions Large patch of infiltration, large area of consolidation, ground-glass shadow, diffuse lung lesion and involvement of both lungs were the main X-ray image characteristics of patients with severe SARS. Large area of ground-glass shadow with air bronchogram in both lungs indicated a bad prognosis.

  17. An objectively-analyzed method for measuring the useful penetration of x-ray imaging systems

    Science.gov (United States)

    Glover, Jack L.; Hudson, Lawrence T.

    2016-06-01

    The ability to detect wires is an important capability of the cabinet x-ray imaging systems that are used in aviation security as well as the portable x-ray systems that are used by domestic law enforcement and military bomb squads. A number of national and international standards describe methods for testing this capability using the so called useful penetration test metric, where wires are imaged behind different thicknesses of blocking material. Presently, these tests are scored based on human judgments of wire visibility, which are inherently subjective. We propose a new method in which the useful penetration capabilities of an x-ray system are objectively evaluated by an image processing algorithm operating on digital images of a standard test object. The algorithm advantageously applies the Radon transform for curve parameter detection that reduces the problem of wire detection from two dimensions to one. The sensitivity of the wire detection method is adjustable and we demonstrate how the threshold parameter can be set to give agreement with human-judged results. The method was developed to be used in technical performance standards and is currently under ballot for inclusion in an international aviation security standard.

  18. A directly converting high-resolution intra-oral X-ray imaging sensor

    CERN Document Server

    Spartiotis, K; Schulman, T; Puhakka, K; Muukkonen, K

    2003-01-01

    A digital intra-oral X-ray imaging sensor with an active area of 3.6x2.9 cm sup 2 and consisting of six charge-integrating CMOS signal readout circuits bump bonded to one high-resistivity silicon pixel detector has been developed and tested. The pixel size is 35 mu m. The X-rays entering the sensor window are converted directly to electrical charge in the depleted detector material yielding minimum lateral signal spread and maximum image sharpness. The signal charge is collected on the gates of the input field effect transistors of the CMOS signal readout circuits. The analog signal readout is performed by multiplexing in the current mode independent of the signal charge collection enabling multiple readout cycles with negligible dead time and thus imaging with wide dynamic range. Since no intermediate conversion material of X-rays to visible light is needed, the sensor structure is very compact. The analog image signals are guided from the sensor output through a thin cable to signal processing, AD conversio...

  19. Fast scale-invariant lateral lumbar vertebrae detection and segmentation in X-ray images.

    Science.gov (United States)

    Sa, Ruhan; Owens, William; Wiegand, Raymond; Chaudhary, Vipin; Sa, Ruhan; Owens, William; Wiegand, Raymond; Chaudhary, Vipin; Owens, William; Sa, Ruhan; Wiegand, Raymond; Chaudhary, Vipin

    2016-08-01

    Fully automatic localization of lumbar vertebrae from clinical X-ray images is very challenging due to the variation of X-ray quality, scale, contrast, number of visible vertebrae, etc. To overcome these challenges, we present a novel framework, where we accelerate a scale-invariant object detection method using Support Vector Machines (SVM) trained on Histogram of Oriented Gradients (HOG) features and segmenting a fine vertebra contour using Gradient Vector Flow (GVF) based snake model. Support Vector Machines trained on HOG features are now an object detection standard in many perception fields and have demonstrated good performance on medical images as well. However, the computational complexity and lack of robustness brought by rescaling the original images have prevented its applicability. The proposed multistage detection framework uses lower-level detection result to determine the rescaling regions to reduce the region of interest, thereby decreasing the execution time. We further refine the detection result by segmenting the contour of vertebra using GVF snake, where we use edge detection techniques to increase the robustness of the GVF snake. Finally, we experimentally demonstrate the effectiveness of this framework using a large set of clinical X-ray images.

  20. Twin image removal in X-ray fluorescence holography with two energies

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In the last decade,X-ray fluorescence holography has been developed for the study of 3D atomic arrangements in solids.However,it encounters the twin image problem which may disturb the reconstructed atomic images.In this paper,the formation of twin image is discussed and we propose a modified two-energy algorithm to remove the twin image.The simulation shows that the method is valid and more efficient than the multiple-energy algorithm proposed by Barton.

  1. Near-field x-ray phase contrast imaging and phase retrieval algorithm

    Institute of Scientific and Technical Information of China (English)

    Zhu Hua-Feng; Xie Hong-Lan; Gao Hong-Yi; Chen Jian-Wen; Li Ru-Xin; Xu Zhi-Zhan

    2005-01-01

    Theoretical analyses of x-ray diffraction phase contrast imaging and near field phase retrieval method are presented.A new variant of the near field intensity distribution is derived with the optimal phase imaging distance and spatial frequency of object taken into account. Numerical examples of phase retrieval using simulated data are also given. On the above basis, the influence of detecting distance and polychroism of radiation on the phase contrast image and the retrieved phase distribution are discussed. The present results should be useful in the practical application of in-line phase contrast imaging.

  2. Imaging of complex density in silver nanocubes by coherent x-ray diffraction

    Science.gov (United States)

    Harder, R.; Liang, M.; Sun, Y.; Xia, Y.; Robinson, I. K.

    2010-03-01

    When using coherent x-rays to perform lensless imaging, it is the complex wave field exiting the sample or, in the case of the Bragg geometry, the deformed electron density distribution of a crystal, that is being sought. For most samples, to some extent, the image will be complex, containing both an amplitude and phase variation across the sample. We have developed versions of the hybrid input-output (HIO) and error reduction (ER) algorithms that are very robust for the inversion to complex objects from three-dimensional (3D) coherent x-ray diffraction (CXD) data measured around a Bragg spot of a small crystal. The development and behavior of these algorithms will be discussed in the context of inverting a 3D CXD pattern measured around a (111) Bragg spot of a silver nanocube.

  3. K-edge digital subtraction imaging based on a dichromatic and compact x-ray source

    Energy Technology Data Exchange (ETDEWEB)

    Sarnelli, A [Dipartimento di Fisica dell' Universita di Ferrara and INFN Sezione di Ferrara, Via Paradiso 12, I-44100 Ferrara (Italy); Taibi, A [Dipartimento di Fisica dell' Universita di Ferrara and INFN Sezione di Ferrara, Via Paradiso 12, I-44100 Ferrara (Italy); Tuffanelli, A [Dipartimento di Fisica dell' Universita di Ferrara and INFN Sezione di Ferrara, Via Paradiso 12, I-44100 Ferrara (Italy); Baldazzi, G [Dipartimento di Fisica dell' Universita di Bologna and INFN Sezione di Bologna, Viale Berti Pichat 64/2, 40127 Bologna (Italy); Bollini, D [Dipartimento di Fisica dell' Universita di Bologna and INFN Sezione di Bologna, Viale Berti Pichat 64/2, 40127 Bologna (Italy); Rodriguez, A E Cabal [CAEDAN, Havana (Cuba); Gombia, M [Dipartimento di Fisica dell' Universita di Bologna and INFN Sezione di Bologna, Viale Berti Pichat 64/2, 40127 Bologna (Italy); Prino, F [Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale and INFN Sezione di Alessandria, C.so, Borsalino 54, I-15100 Alessandria (Italy); Ramello, L [Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale and INFN Sezione di Alessandria, C.so, Borsalino 54, I-15100 Alessandria (Italy); Tomassi, E [Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale and INFN Sezione di Alessandria, C.so, Borsalino 54, I-15100 Alessandria (Italy); Gambaccini, M [Dipartimento di Fisica dell' Universita di Ferrara and INFN Sezione di Ferrara, Via Paradiso 12, I-44100 Ferrara (Italy)

    2004-07-21

    This work proposes a compact dichromatic imaging system for the application of the K-edge digital subtraction technique based on a conventional x-ray tube and a monochromator system. A quasi-monochromatic x-ray beam at the energy of iodine K-edge is produced by Bragg diffraction on a mosaic crystal. Two thin adjacent beams with energies that bracket the K-edge discontinuity are obtained from the diffracted beam by means of a proper collimation system. They are then detected using an array of Si detectors. A home-made phantom is used to study the image quality as a function of iodine concentration. Signal and signal-to-noise ratio analysis has also been performed. The results are compared with theoretical expectations.

  4. Heterogeneous computing for vertebra detection and segmentation in x-ray images.

    Science.gov (United States)

    Lecron, Fabian; Mahmoudi, Sidi Ahmed; Benjelloun, Mohammed; Mahmoudi, Saïd; Manneback, Pierre

    2011-01-01

    The context of this work is related to the vertebra segmentation. The method we propose is based on the active shape model (ASM). An original approach taking advantage of the edge polygonal approximation was developed to locate the vertebra positions in a X-ray image. Despite the fact that segmentation results show good efficiency, the time is a key variable that has always to be optimized in a medical context. Therefore, we present how vertebra extraction can efficiently be performed in exploiting the full computing power of parallel (GPU) and heterogeneous (multi-CPU/multi-GPU) architectures. We propose a parallel hybrid implementation of the most intensive steps enabling to boost performance. Experimentations have been conducted using a set of high-resolution X-ray medical images, showing a global speedup ranging from 3 to 22, by comparison with the CPU implementation. Data transfer times between CPU and GPU memories were included in the execution times of our proposed implementation.

  5. Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast

    Institute of Scientific and Technical Information of China (English)

    XIAO Ti-Qiao; ZHANG Gui-Lin; XU Hong-Jie; TIAN Yu-Lian; HUANG Wan-Xia; ZHU Pei-Ping

    2003-01-01

    An experimental study on nondestructive X-ray imaging of inner structure of soft tissues in phase con-trast has been conducted with Beijing Synchrotron Radiation Facility (BSRF). Modification to the beamline setupwas made to enlarge the X-ray beam section and consequently larger samples could be imaged. In-line setup was em-ployed for experiments. Results on a series of samples were given and soft-tissue details of less than 50 μm inside afresh goldfish were obtained. Diagnosis of tumor in its early stage was also investigated taking SD rats as the model.Tumor at the size of ~ 100μm was observed. Potential of this technique in clinic diagnosis was discussed.

  6. Object image correction using an X-ray dynamical diffraction Fraunhofer hologram.

    Science.gov (United States)

    Balyan, Minas K

    2014-03-01

    Taking into account background correction and using Fourier analysis, a numerical method of an object image correction using an X-ray dynamical diffraction Fraunhofer hologram is presented. An example of the image correction of a cylindrical beryllium wire is considered. A background correction of second-order iteration leads to an almost precise reconstruction of the real part of the amplitude transmission coefficient and improves the imaginary part compared with that without a background correction. Using Fourier analysis of the reconstructed transmission coefficient, non-physical oscillations can be avoided. This method can be applied for the determination of the complex amplitude transmission coefficient of amplitude as well as phase objects, and can be used in X-ray microscopy.

  7. High energy X-ray photon counting imaging using linear accelerator and silicon strip detectors

    Science.gov (United States)

    Tian, Y.; Shimazoe, K.; Yan, X.; Ueda, O.; Ishikura, T.; Fujiwara, T.; Uesaka, M.; Ohno, M.; Tomita, H.; Yoshihara, Y.; Takahashi, H.

    2016-09-01

    A photon counting imaging detector system for high energy X-rays is developed for on-site non-destructive testing of thick objects. One-dimensional silicon strip (1 mm pitch) detectors are stacked to form a two-dimensional edge-on module. Each detector is connected to a 48-channel application specific integrated circuit (ASIC). The threshold-triggered events are recorded by a field programmable gate array based counter in each channel. The detector prototype is tested using 950 kV linear accelerator X-rays. The fast CR shaper (300 ns pulse width) of the ASIC makes it possible to deal with the high instant count rate during the 2 μs beam pulse. The preliminary imaging results of several metal and concrete samples are demonstrated.

  8. SuperAGILE: the hard X-ray Imager for the AGILE space mission

    CERN Document Server

    Feroci, M; Soffitta, P; Del Monte, E; Di Persio, G; Donnarumma, I; Evangelista, Y; Frutti, M; Lapshov, I; Lazzarotto, F; Mastropietro, M; Morelli, E; Pacciani, L; Porrovecchio, G; Rapisarda, M; Rubini, A; Tavani, M; Argan, A

    2007-01-01

    SuperAGILE is a coded mask experiment based on silicon microstrip detectors. It operates in the 15-45 keV nominal energy range, providing crossed one-dimensional images of the X-ray sky with an on-axis angular resolution of 6 arcmin, over a field of view in excess of 1 steradian. It was designed as the hard X-ray monitor of the AGILE space mission, a small satellite of the Italian Space Agency devoted to image the gamma-ray sky in the 30 MeV - 50 GeV energy band. The AGILE mission was launched in a low-earth orbit on 23^{rd} April 2007. In this paper we describe the SuperAGILE experiment, its construction and test processes, and its performance before flight, based on the on-ground test and calibrations.

  9. High energy X-ray photon counting imaging using linear accelerator and silicon strip detectors

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Y., E-mail: cycjty@sophie.q.t.u-tokyo.ac.jp [Department of Bioengineering, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Shimazoe, K.; Yan, X. [Department of Nuclear Engineering and Management, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Ueda, O.; Ishikura, T. [Fuji Electric Co., Ltd., Fuji, Hino, Tokyo 191-8502 (Japan); Fujiwara, T. [National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568 (Japan); Uesaka, M.; Ohno, M. [Nuclear Professional School, the University of Tokyo, 2-22 Shirakata-shirane, Tokai, Ibaraki 319-1188 (Japan); Tomita, H. [Department of Quantum Engineering, Nagoya University, Furo, Chikusa, Nagoya 464-8603 (Japan); Yoshihara, Y. [Department of Nuclear Engineering and Management, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Takahashi, H. [Department of Bioengineering, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Department of Nuclear Engineering and Management, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

    2016-09-11

    A photon counting imaging detector system for high energy X-rays is developed for on-site non-destructive testing of thick objects. One-dimensional silicon strip (1 mm pitch) detectors are stacked to form a two-dimensional edge-on module. Each detector is connected to a 48-channel application specific integrated circuit (ASIC). The threshold-triggered events are recorded by a field programmable gate array based counter in each channel. The detector prototype is tested using 950 kV linear accelerator X-rays. The fast CR shaper (300 ns pulse width) of the ASIC makes it possible to deal with the high instant count rate during the 2 μs beam pulse. The preliminary imaging results of several metal and concrete samples are demonstrated.

  10. Combining ordered subsets and momentum for accelerated X-ray CT image reconstruction.

    Science.gov (United States)

    Kim, Donghwan; Ramani, Sathish; Fessler, Jeffrey A

    2015-01-01

    Statistical X-ray computed tomography (CT) reconstruction can improve image quality from reduced dose scans, but requires very long computation time. Ordered subsets (OS) methods have been widely used for research in X-ray CT statistical image reconstruction (and are used in clinical PET and SPECT reconstruction). In particular, OS methods based on separable quadratic surrogates (OS-SQS) are massively parallelizable and are well suited to modern computing architectures, but the number of iterations required for convergence should be reduced for better practical use. This paper introduces OS-SQS-momentum algorithms that combine Nesterov's momentum techniques with OS-SQS methods, greatly improving convergence speed in early iterations. If the number of subsets is too large, the OS-SQS-momentum methods can be unstable, so we propose diminishing step sizes that stabilize the method while preserving the very fast convergence behavior. Experiments with simulated and real 3D CT scan data illustrate the performance of the proposed algorithms.

  11. Background Simulations of the Wide Field Imager of the ATHENA X-Ray Observatory

    CERN Document Server

    Hauf, Steffen; Pia, Maria Grazia; Hoffmann, Dieter H H; Lang, Philipp; Neff, Stephan; Stefanescu, Alexander; Strüder, Lothar

    2011-01-01

    The ATHENA X-ray Observatory-IXO is a planned multinational orbiting X-ray observatory with a focal length of 11.5m. ATHENA aims to perform pointed observations in an energy range from 0.1 keV to 15 keV with high sensitivity. For high spatial and timing resolution imaging and spectroscopic observations the 640x640 pixel^2 large DePFET-technology based Wide field Imager (WFI) focal plane detector, providing a field of view of 18 arcsec will be the main detector. Based on the actual mechanics, thermal and shielding design we present estimates for the WFI cosmic ray induced background obtained by the use of Monte-Carlo simulations and possible background reduction measures.

  12. K-edge digital subtraction imaging based on a dichromatic and compact x-ray source

    Science.gov (United States)

    Sarnelli, A.; Taibi, A.; Tuffanelli, A.; Baldazzi, G.; Bollini, D.; Cabal Rodriguez, A. E.; Gombia, M.; Prino, F.; Ramello, L.; Tomassi, E.; Gambaccini, M.

    2004-07-01

    This work proposes a compact dichromatic imaging system for the application of the K-edge digital subtraction technique based on a conventional x-ray tube and a monochromator system. A quasi-monochromatic x-ray beam at the energy of iodine K-edge is produced by Bragg diffraction on a mosaic crystal. Two thin adjacent beams with energies that bracket the K-edge discontinuity are obtained from the diffracted beam by means of a proper collimation system. They are then detected using an array of Si detectors. A home-made phantom is used to study the image quality as a function of iodine concentration. Signal and signal-to-noise ratio analysis has also been performed. The results are compared with theoretical expectations.

  13. Future Development Trajectories for Imaging X-rays Spectrometers Based on Microcalorimeters

    Science.gov (United States)

    Kilbourne, Caroline A.; Bandler, Simon R.

    2013-01-01

    Future development trajectories for imaging x-ray spectrometers based on microcalorimeters. Since their invention 30 years ago, the capability of X-ray microcalorimeters has increased steadily, with continual improvements in energy resolution, speed, and array size. Arrays of up to 1024 pixels have been produced, and resolution better than 1 eV at 1.5 keV has been achieved. These detectors can be optimized for the highest priority science, such as designing for the highest resolving power at low energies at the expense of dynamic range, or the greatest focal-plane coverage at the expense of speed. Three types of X-ray microcalorimeters presently dominate the field, each characterized by the thermometer technology. The first two types use temperature-sensitive resistors: semiconductors in the metal-insulator transition and superconductors operated in the superconducting-normal transition. The third type uses a magnetically coupled thermometer, and is at an earlier stage of development than the other two. The Soft X-ray Spectrometer (SXS) on Astro-H, expected to launch in 2015, will use an array of silicon thermistors with HgTe X-ray absorbers that will operate at 50 mK. Both the semiconductor and superconductor calorimeters have been implemented in small arrays. Kilopixel arrays of the superconducting calorimeters are being produced, and much larger arrays may require the non-dissipative advantage of magnetically coupled thermometers. I will project the development trajectories of these detectors and their read-out technologies and assess what their capabilities and limitations will be 10 - 20 years from now.

  14. Taheri-Saramad x-ray detector (TSXD): A novel high spatial resolution x-ray imager based on ZnO nano scintillator wires in polycarbonate membrane

    Energy Technology Data Exchange (ETDEWEB)

    Taheri, A., E-mail: at1361@aut.ac.ir; Saramad, S.; Ghalenoei, S.; Setayeshi, S. [Department of Energy Engineering and Physics, Amirkabir University of Technology, Tehran 15875-4413 (Iran, Islamic Republic of)

    2014-01-15

    A novel x-ray imager based on ZnO nanowires is designed and fabricated. The proposed architecture is based on scintillation properties of ZnO nanostructures in a polycarbonate track-etched membrane. Because of higher refractive index of ZnO nanowire compared to the membrane, the nanowire acts as an optical fiber that prevents the generated optical photons to spread inside the detector. This effect improves the spatial resolution of the imager. The detection quantum efficiency and spatial resolution of the fabricated imager are 11% and <6.8 μm, respectively.

  15. Taheri-Saramad x-ray detector (TSXD): A novel high spatial resolution x-ray imager based on ZnO nano scintillator wires in polycarbonate membrane

    Science.gov (United States)

    Taheri, A.; Saramad, S.; Ghalenoei, S.; Setayeshi, S.

    2014-01-01

    A novel x-ray imager based on ZnO nanowires is designed and fabricated. The proposed architecture is based on scintillation properties of ZnO nanostructures in a polycarbonate track-etched membrane. Because of higher refractive index of ZnO nanowire compared to the membrane, the nanowire acts as an optical fiber that prevents the generated optical photons to spread inside the detector. This effect improves the spatial resolution of the imager. The detection quantum efficiency and spatial resolution of the fabricated imager are 11% and <6.8 μm, respectively.

  16. Impact of large x-ray beam collimation on image quality

    Science.gov (United States)

    Racine, Damien; Ba, Alexandre; Ott, Julien G.; Bochud, François O.; Verdun, Francis R.

    2016-03-01

    Large X-ray beam collimation in computed tomography (CT) opens the way to new image acquisition techniques and improves patient management for several clinical indications. The systems that offer large X-ray beam collimation enable, in particular, a whole region of interest to be investigated with an excellent temporal resolution. However, one of the potential drawbacks of this option might be a noticeable difference in image quality along the z-axis when compared with the standard helical acquisition mode using more restricted X-ray beam collimations. The aim of this project is to investigate the impact of the use of large X-ray beam collimation and new iterative reconstruction on noise properties, spatial resolution and low contrast detectability (LCD). An anthropomorphic phantom and a custom made phantom were scanned on a GE Revolution CT. The images were reconstructed respectively with ASIR-V at 0% and 50%. Noise power spectra, to evaluate the noise properties, and Target Transfer Functions, to evaluate the spatial resolution, were computed. Then, a Channelized Hotelling Observer with Gabor and Dense Difference of Gaussian channels was used to evaluate the LCD using the Percentage correct as a figure of merit. Noticeable differences of 3D noise power spectra and MTF have been recorded; however no significant difference appeared when dealing with the LCD criteria. As expected the use of iterative reconstruction, for a given CTDIvol level, allowed a significant gain in LCD in comparison to ASIR-V 0%. In addition, the outcomes of the NPS and TTF metrics led to results that would contradict the outcomes of CHO model observers if used for a NPWE model observer (Non- Prewhitening With Eye filter). The unit investigated provides major advantages for cardiac diagnosis without impairing the image quality level of standard chest or abdominal acquisitions.

  17. Imaging mammalian cells with soft x rays: The importance of specimen preparation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J.T.; Meyer-Ilse, W. [Ernest Orlando Lawrence Berkeley National Lab., CA (United States)

    1997-04-01

    Studies of mammalian cell structure and spatial organization are a very prominent part of modern cell biology. The interest in them as well as their size make them very accommodating subject specimens for imaging with soft x-rays using the XM-1 transmission microscope built and operated by The Center for X-ray Optics on Beam Line 6.1 at the Advanced Light Source. The purpose of these experiments was to determine if the fixative protocols normally used in electron or visible light microscopy were adequate to allow imaging cells, either fibroblasts or neurons, with minimal visible radiation damage due to imaging with soft x-rays at 2.4 nm. Two cell types were selected. Fibroblasts are easily cultured but fragile cells which are commonly used as models for the detailed study of cell physiology. Neurons are complex and sensitive cells which are difficult to prepare and to culture for study in isolation from their connections with surrounding cells. These cell types pose problems in their preparation for any microscopy. To improve the contrast and to prevent postmortem alteration of the chemistry and hence the structure of cells extracted from culture or from living organisms, fixation and staining techniques are employed in electron and visible light microscopy. It has been accepted by biologists for years that these treatments create artifacts and false structure. The authors have begun to develop protocols for specimens of each of these two cell types for soft x-ray microscopy which will preserve them in as near normal state as possible using minimal fixation, and make it possible to image them in either a hydrated or dried state free of secondary addition of stains or other labels.

  18. X-ray reduction imaging of inclined reflective masks at critical angles

    Science.gov (United States)

    Artyukov, I. A.; Busarov, A. C.; Vinogradov, A. V.; Popov, N. L.

    2016-09-01

    We have proposed and simulated optical schemes for producing reduced images by X-ray lasers or harmonic generators at a wavelength of ~14 nm. The mask in this case is placed at a small angle to the optical axis, corresponding to the angle of total external reflection of the material. We have determined the optimal position of the detector (resist) and the corresponding spatial resolution. The results can be used to solve problems in nanotechnology and nanostructuring of surfaces.

  19. An X-ray Imaging System for Hard-to-Reach Facility Diagnosis Using Femtosecond Laser-Plasma

    Science.gov (United States)

    Oishi, Yuji; Nayuki, Takuya; Nakajima, Chikahito; Fujii, Takashi; Zhidkov, Alexei; Nemoto, Koshichi

    2010-04-01

    For hard-to-reach facility diagnosis, a radiographic testing system that consists of a compact laser-plasma X-ray (LPX) generator and a compact X-ray imaging sensor is shown to be competitive to that based on the isotope imaging. A 1-mm-thick CsI charge-coupled device (CCD) sensor supplied with a cooling system was developed to tolerate a long X-ray exposition. Even without optimization of X-ray yield from a Ta thin film irradiated by 230 mJ, 70 fs laser pulses, clear X-ray images of a SUS304 pipe (outer diameter 34 mm with 4.5 mm thickness) with an elbow were produced.

  20. A concept to collect neutron and x-ray images on the same line of sight at NIF

    Energy Technology Data Exchange (ETDEWEB)

    Merrill, F. E., E-mail: fmerrill@lanl.gov; Danly, C. R.; Grim, G. P.; Volegov, P. L.; Wilde, C. H. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Izumi, N.; Jedlovec, D.; Fittinghoff, D. N.; Pak, A.; Park, H.-S. [Livermore National Laboratory, Livermore, California 94551 (United States)

    2014-11-15

    Neutron and x-ray images are collected at the National Ignition Facility (NIF) to measure the size and shape of inertial confinement fusion implosions. The x-ray images provide a measure of the size and shape of the hot region of the deuterium-tritium fuel while the neutron images provide a measure of the size and shape of the burning plasma. Although these two types of images are collected simultaneously, they are not collected along the same line of sight (LOS). One 14 MeV neutron image is collected on the NIF equator, and two x-ray images are collected along the polar axis and nearly perpendicular to the neutron imaging line of sight on the equator. Both measurements use pinhole apertures to form the images, but existing x-ray imaging provides time-resolved measurements while the neutron images are time-integrated. Detailed comparisons of the x-ray and neutron images can provide information on the fuel assembly, but these studies have been limited because the implosions are not azimuthally symmetric and the images are collected along different LOS. We have developed a conceptual design of a time-integrated x-ray imaging system that could be added to the existing neutron imaging LOS. This new system would allow these detailed studies, providing important information on the fuel assembly of future implosions. Here we present this conceptual design and the expected performance characteristics.

  1. A concept to collect neutron and x-ray images on the same line of sight at NIF.

    Science.gov (United States)

    Merrill, F E; Danly, C R; Izumi, N; Jedlovec, D; Fittinghoff, D N; Grim, G P; Pak, A; Park, H-S; Volegov, P L; Wilde, C H

    2014-11-01

    Neutron and x-ray images are collected at the National Ignition Facility (NIF) to measure the size and shape of inertial confinement fusion implosions. The x-ray images provide a measure of the size and shape of the hot region of the deuterium-tritium fuel while the neutron images provide a measure of the size and shape of the burning plasma. Although these two types of images are collected simultaneously, they are not collected along the same line of sight (LOS). One 14 MeV neutron image is collected on the NIF equator, and two x-ray images are collected along the polar axis and nearly perpendicular to the neutron imaging line of sight on the equator. Both measurements use pinhole apertures to form the images, but existing x-ray imaging provides time-resolved measurements while the neutron images are time-integrated. Detailed comparisons of the x-ray and neutron images can provide information on the fuel assembly, but these studies have been limited because the implosions are not azimuthally symmetric and the images are collected along different LOS. We have developed a conceptual design of a time-integrated x-ray imaging system that could be added to the existing neutron imaging LOS. This new system would allow these detailed studies, providing important information on the fuel assembly of future implosions. Here we present this conceptual design and the expected performance characteristics.

  2. Calculations and surface quality measurements of high-asymmetry angle x-ray crystal monochromators for advanced x-ray imaging and metrological applications

    Science.gov (United States)

    Zápražný, Zdenko; Korytár, Dušan; Jergel, Matej; Šiffalovič, Peter; Dobročka, Edmund; Vagovič, Patrik; Ferrari, Claudio; Mikulík, Petr; Demydenko, Maksym; Mikloška, Marek

    2015-03-01

    We present the numerical optimization and the technological development progress of x-ray optics based on asymmetric germanium crystals. We show the results of several basic calculations of diffraction properties of germanium x-ray crystal monochromators and of an analyzer-based imaging method for various asymmetry factors using an x-ray energy range from 8 to 20 keV. The important parameter of highly asymmetric monochromators as image magnifiers or compressors is the crystal surface quality. We have applied several crystal surface finishing methods, including advanced nanomachining using single-point diamond turning (SPDT), conventional mechanical lapping, chemical polishing, and chemomechanical polishing, and we have evaluated these methods by means of atomic force microscopy, diffractometry, reciprocal space mapping, and others. Our goal is to exclude the chemical etching methods as the final processing technique because it causes surface undulations. The aim is to implement very precise deterministic methods with a control of surface roughness down to 0.1 nm. The smallest roughness (˜0.3 nm), best planarity, and absence of the subsurface damage were observed for the sample which was machined using an SPDT with a feed rate of 1 mm/min and was consequently polished using a fine polishing 15-min process with a solution containing SiO2 nanoparticles (20 nm).

  3. Nondestructive Imaging of Internal Structures of Frog (Xenopus laevis) Embryos by Shadow-Projection X-Ray Microtomography

    Science.gov (United States)

    Aoki, Sadao; Yoneda, Ikuo; Nagai, Takeharu; Ueno, Naoto; Murakami, Kazuo

    1994-04-01

    Nondestructive high-resolution imaging of frog ( Xenopus laevis) embryos has been developed by X-ray microtomography. Shadow-projection X-ray microtomography with a brilliant fine focus laboratory X-ray source could image fine structures of Xenopus embryos which were embedded in paraffin wax. The imaging system enabled us to not only distinguish endoderm from ectoderm at the gastrula stage, but also to obtain a cross-section view of the tail bud embryo showing muscle, notochord and neural tube without staining. Furthermore, the distribution of myosin was also imaged in combination with whole-mount immunohistochemistry.

  4. Contribute to quantitative identification of casting defects based on computer analysis of X-ray images

    Directory of Open Access Journals (Sweden)

    Z. Ignaszak

    2007-12-01

    Full Text Available The forecast of structure and properties of casting is based on results of computer simulation of physical processes which are carried out during the casting processes. For the effective using of simulation system it is necessary to validate mathematica-physical models describing process of casting formation and the creation of local discontinues, witch determinate the casting properties.In the paper the proposition for quantitative validation of VP system using solidification casting defects by information sources of II group (methods of NDT was introduced. It was named the VP/RT validation (virtual prototyping/radiographic testing validation. Nowadays identification of casting defects noticeable on X-ray images bases on comparison of X-ray image of casting with relates to the ASTM. The results of this comparison are often not conclusive because based on operator’s subjective assessment. In the paper the system of quantitative identification of iron casting defects on X-ray images and classification this defects to ASTM class is presented. The methods of pattern recognition and machine learning were applied.

  5. X-ray Imaging Using a Hybrid Photon Counting GaAs Pixel Detector

    CERN Document Server

    Schwarz, C; Göppert, R; Heijne, Erik H M; Ludwig, J; Meddeler, G; Mikulec, B; Pernigotti, E; Rogalla, M; Runge, K; Smith, K M; Snoeys, W; Söldner-Rembold, S; Watt, J

    1999-01-01

    The performance of hybrid GaAs pixel detectors as X-ray imaging sensors were investigated at room temperature. These hybrids consist of 300 mu-m thick GaAs pixel detectors, flip-chip bonded to a CMOS Single Photon Counting Chip (PCC). This chip consists of a matrix of 64 x 64 identical square pixels (170 mu-m x 170 mu-m) and covers a total area of 1.2 cm**2. The electronics in each cell comprises a preamplifier, a discriminator with a 3-bit threshold adjust and a 15-bit counter. The detector is realized by an array of Schottky diodes processed on semi-insulating LEC-GaAs bulk material. An IV-charcteristic and a detector bias voltage scan showed that the detector can be operated with voltages around 200 V. Images of various objects were taken by using a standard X-ray tube for dental diagnostics. The signal to noise ratio (SNR) was also determined. The applications of these imaging systems range from medical applications like digital mammography or dental X-ray diagnostics to non destructive material testing (...

  6. The Coherent X-ray Imaging (CXI) Instrument at the Linac Coherent Light Source (LCLS)

    Energy Technology Data Exchange (ETDEWEB)

    Boutet, Sebastien; Williams, Garth J.; /SLAC

    2011-08-16

    The Linac Coherent Light Source (LCLS) has become the first ever operational hard X-ray Free Electron Laser in 2009. It will operate as a user facility capable of delivering unique research opportunities in multiple fields of science. The LCLS and the LCLS Ultrafast Science Instruments (LUSI) construction projects are developing instruments designed to make full use of the capabilities afforded by the LCLS beam. One such instrument is being designed to utilize the LCLS coherent beam to image with high resolution any sub-micron object. This instrument is called the Coherent X-ray Imaging (CXI) instrument. This instrument will provide a flexible optical system capable of tailoring key beam parameters for the users. A suite of shot-to-shot diagnostics will also be provided to characterize the beam on every pulse. The provided instrumentation will include multi-purpose sample environments, sample delivery and a custom detector capable of collecting 2D data at 120 Hz. In this article, the LCLS will be briefly introduced along with the technique of Coherent X-ray Diffractive Imaging (CXDI). A few examples of scientific opportunities using the CXI instrument will be described. Finally, the conceptual layout of the instrument will be presented along with a description of the key requirements for the overall system and specific devices required.

  7. Conduction-Zone Measurements Using X-Ray Self-Emission Images

    Science.gov (United States)

    Davis, A. K.; Michel, D. T.; Epstein, R.; Hu, S. X.; Knauer, J. P.; Froula, D. H.

    2016-10-01

    Time-gated soft x-ray self-emission images of directly driven implosions were used to measure the hydrodynamic conditions between the critical-density surface and the ablation front of a CH target (conduction zone) at the beginning of a laser pulse. These images were calibrated using the time-resolved broadband soft x-ray spectrometer Dante, azimuthally averaged to reduce the noise, and Abel-inverted to determine the emissivity at each point in the plasma. The electron temperature was determined using co-timed images taken with three different filters to obtain a coarse measurement of the emission spectrum at each point. With the temperature determined, the density profile in the corona was determined from the emissivity profile. This measurement is critical for inertial confinement fusion since it governs the length of time that the plasma is too small to provide substantial beam smoothing through thermal conduction, determining the laser imprint efficiency. This region has previously proven challenging to probe because the density is too high for optical diagnostics and the temperature is too high for x-ray radiography. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  8. Effects of spatially heterogeneous porosity on matrix diffusion as investigated by X-ray absorption imaging

    Science.gov (United States)

    Tidwell, Vincent C.; Meigs, Lucy C.; Christian-Frear, Tracy; Boney, Craig M.

    2000-03-01

    High-resolution X-ray absorption imaging was used to investigate the effects of spatially heterogeneous porosity on matrix diffusion. Experiments were performed on four, centimeter-scale slabs of Culebra dolomite taken from the Waste Isolation Pilot Plant (WIPP) site. These tests involved the diffusion of potassium iodide into a single edge of each brine-saturated rock slab, while X-ray absorption imaging was used to measure the two-dimensional relative concentration distribution at different times during the experiment. X-ray imaging was also used to measure the heterogeneous, two-dimensional porosity distribution of each rock slab. The resulting high-resolution data provide unique insight into the spatially varying diffusion characteristics of each heterogeneous rock sample, which traditional methods such as through-diffusion experiments cannot. In these tests, significant variations in the diffusion coefficient were calculated over the relatively small length (centimeter) and time scales (months) investigated. Results also indicated that these variations were related to the heterogeneous porosity characteristics of each rock sample. Not only were the diffusion coefficients found to depend on the magnitude of the porosity but also on its spatial distribution. Specifically, the geometry, position, and orientation of the heterogeneous porosity features populating each rock slab appeared to influence the diffusion characteristics.

  9. Absorption and Phase Contrast X-Ray Imaging in Paleontology Using Laboratory and Synchrotron Sources.

    Science.gov (United States)

    Bidola, Pidassa; Stockmar, Marco; Achterhold, Klaus; Pfeiffer, Franz; Pacheco, Mírian L A F; Soriano, Carmen; Beckmann, Felix; Herzen, Julia

    2015-10-01

    X-ray micro-computed tomography (μCT) is commonly used for imaging of samples in biomedical or materials science research. Owing to the ability to visualize a sample in a nondestructive way, X-ray μCT is perfectly suited to inspect fossilized specimens, which are mostly unique or rare. In certain regions of the world where important sedimentation events occurred in the Precambrian geological time, several fossilized animals are studied to understand questions related to their origin, environment, and life evolution. This article demonstrates the advantages of applying absorption and phase-contrast CT on the enigmatic fossil Corumbella werneri, one of the oldest known animals capable of building hard parts, originally discovered in Corumbá (Brazil). Different tomographic setups were tested to visualize the fossilized inner structures: a commercial laboratory-based μCT device, two synchrotron-based imaging setups using conventional absorption and propagation-based phase contrast, and a commercial X-ray microscope with a lens-coupled detector system, dedicated for radiography and tomography. Based on our results we discuss the strengths and weaknesses of the different imaging setups for paleontological studies.

  10. Absorption and Phase Contrast X-Ray Imaging in Paleontology Using Laboratory and Synchrotron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Bidola, Pidassa; Stockmar, Marco; Achterhold, Klaus; Pfeiffer, Franz; Pacheco, Mirian L.A.F.; Soriano, Carmen; Beckmann, Felix; Herzen, Julia

    2015-10-01

    X-ray micro-computed tomography (CT) is commonly used for imaging of samples in biomedical or materials science research. Owing to the ability to visualize a sample in a nondestructive way, X-ray CT is perfectly suited to inspect fossilized specimens, which are mostly unique or rare. In certain regions of the world where important sedimentation events occurred in the Precambrian geological time, several fossilized animals are studied to understand questions related to their origin, environment, and life evolution. This article demonstrates the advantages of applying absorption and phase-contrast CT on the enigmatic fossil Corumbella werneri, one of the oldest known animals capable of building hard parts, originally discovered in Corumba (Brazil). Different tomographic setups were tested to visualize the fossilized inner structures: a commercial laboratory-based CT device, two synchrotron-based imaging setups using conventional absorption and propagation-based phase contrast, and a commercial X-ray microscope with a lens-coupled detector system, dedicated for radiography and tomography. Based on our results we discuss the strengths and weaknesses of the different imaging setups for paleontological studies.

  11. A multi-cone x-ray imaging Bragg crystal spectrometer

    Science.gov (United States)

    Bitter, Manfred; Hill, K. W.; Gao, Lan; Efthimion, P. C.; Delgado-Aparicio, L.; Lazerson, S.; Pablant, N.

    2016-10-01

    In a recent article, see, we described a new x-ray imaging Bragg crystal spectrometer, which - in combination with a streak camera or a gated strip detector - can be used for time-resolved measurements of x-ray line spectra at the National Ignition Facility (NIF) and other high power laser facilities. The main advantage of this instrument is that it produces perfect images of a point source for each wavelength in a selectable spectral range and that the detector plane can be inclined by an arbitrary angle with respect to the crystal surface. These unique imaging properties are obtained by bending the x-ray diffracting crystal into a certain shape, which is generated by arranging multiple cones with different aperture angles on a common nodal line. In this paper, we present results from optical tests of these multi-cone structures and numerical results on the deteriorations of the spectral and spatial resolutions that may be caused by potential misalignments of the source, crystal, and detector. Princeton Plasma Physics Laboratory.

  12. Ultrafast coherent diffractive imaging of nanoparticles using X-ray free-electron laser radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kassemeyer, Stephan

    2014-05-20

    Coherent diffractive imaging with X-ray free-electron lasers (X-FEL) promises high-resolution structure determination of single microscopic particles without the need for crystallization. The diffraction signal of small samples can be very weak, a difficulty that can not be countered by merely increasing the number of photons because the sample would be damaged by a high absorbed radiation dose. Traditional X-ray crystallography avoids this problem by bringing many sample particles into a periodic arrangement, which amplifies the individual signals while distributing the absorbed dose. Depending on the sample, however, crystallization can be very difficult or even impossible. This thesis presents algorithms for a new imaging approach using X-FEL radiation that works with single, non-crystalline sample particles. X-FELs can deliver X-rays with a peak brilliance many orders of magnitude higher than conventional X-ray sources, compensating for their weak interaction cross sections. At the same time, FELs can produce ultra-short pulses down to a few femtoseconds. In this way it is possible to perform ultra-fast imaging, essentially ''freezing'' the atomic positions in time and terminating the imaging process before the sample is destroyed by the absorbed radiation. This thesis primarily focuses on the three-dimensional reconstruction of single (and not necessarily crystalline) particles using coherent diffractive imaging at X-FELs: in order to extract three-dimensional information from scattering data, two-dimensional diffraction patterns from many different viewing angles must be combined. Therefore, the diffraction signal of many identical sample copies in random orientations is measured. The main result of this work is a globally optimal algorithm that can recover the sample orientations solely based on the diffraction signal, enabling three-dimensional imaging for arbitrary samples. The problem of finding three-dimensional orientations is

  13. Objective for EUV microscopy, EUV lithography, and x-ray imaging

    Science.gov (United States)

    Bitter, Manfred; Hill, Kenneth W.; Efthimion, Philip

    2016-05-03

    Disclosed is an imaging apparatus for EUV spectroscopy, EUV microscopy, EUV lithography, and x-ray imaging. This new imaging apparatus could, in particular, make significant contributions to EUV lithography at wavelengths in the range from 10 to 15 nm, which is presently being developed for the manufacturing of the next-generation integrated circuits. The disclosure provides a novel adjustable imaging apparatus that allows for the production of stigmatic images in x-ray imaging, EUV imaging, and EUVL. The imaging apparatus of the present invention incorporates additional properties compared to previously described objectives. The use of a pair of spherical reflectors containing a concave and convex arrangement has been applied to a EUV imaging system to allow for the image and optics to all be placed on the same side of a vacuum chamber. Additionally, the two spherical reflector segments previously described have been replaced by two full spheres or, more precisely, two spherical annuli, so that the total photon throughput is largely increased. Finally, the range of permissible Bragg angles and possible magnifications of the objective has been largely increased.

  14. Wide-field x-ray imaging for future missions, including XEUS

    Science.gov (United States)

    Conconi, Paolo; Pareschi, Giovanni; Campana, Sergio; Chincarini, Guido; Tagliaferri, Gianpiero

    2004-02-01

    It is well known that the Wolter I design for focusing X-ray telescopes provides perfect on-axis images, while, despite the absence of spherical aberration, the off-axis angular resolution rapidly degrades because of coma, field curvature and astigmatism. However, more general mirror designs than Wolter's exist in which primary and secondary mirror profiles can be described by polynomial equations. These power series solutions are particularly well indicated to be optimized, in order to achieve high imaging performances even at large off-axis incidence angles, despite a small degradation of the on-axis response. The concept, derived from the Ritchey-Chretien telescope widely used in optical astronomy, has already been experimentally proven for X-ray astronomical applications at the Brera Astronomical Observatory (Italy), in the context of the feasibility study of the Wide Field X-ray Telescope mission. Here we present a new design (including a model for slope errors and mechanical tolerances) for a X-ray telescope of medium-size class assuming monolithic mirror shells made of glass, optimized to have a Half Energy Width better than 5 arcsec over a 30 arcmin field of view (radius) and an effective area almost twice that one of Chandra. The use of polynomial mirrors seems extremely well suited also for the case of the XEUS optics. Indeed, the small aspect-ratio between the large focal length of the XEUS telescope (50 m) and the total mirror height (1 m) makes it very favorable to diminish the aberration effects due to the field curvature. With the assumption of mirror shells with polynomial profile it would be possible to achieve for XEUS an imaging response almost constant up to a field of view of 20 arcmin in radius.

  15. SU-C-18C-03: Dual-Energy X-Ray Fluoroscopy Imaging System

    Energy Technology Data Exchange (ETDEWEB)

    Virshup, G; Richmond, M; Mostafavi, H; Ganguly, A [Ginzton Technology Center, Varian Medical Systems Inc, Palo Alto, CA (United States); Fu, D [Ruier Medical, Wuxi, Jiangsu Province (China)

    2014-06-01

    Purpose: This work studies the clinical utility of dual energy (DE) subtraction fluoroscopy for fiducial-free tumor tracking in lung radiation therapy (RT). Improvement in tumor visualization and quantification of tumor shift within a breathing cycle were analyzed. Methods: Twenty subjects who were undergoing RT for lung cancer were recruited following institutional review board approval. The subjects had a range of tumor sizes, locations in the lungs, and body sizes. An x-ray imaging system was setup with the following components: (a) x-ray tube (Varian G-242, Varian Medical Systems (VMS), CA) (b) flat panel detector (4030CB, VMS, CA) and (c) x-ray generator (EPS 50RF, EMD, Canada). Firmware and software modifications were made to the generator to allow 10 x-ray pulse pairs with alternating low/high kV, 100 ms apart for ∼4s (one breathing cycle). Images were obtained at 4 angles: 0°, 45°, 90° and 135°. Weighted subtraction of a kV-pair image set was used to create a “bone-free” image of the lungs. The 2D tumor-shift in each subtracted image and the 3D shift during a breathing cycle was calculated using all views. Results: The subjects enrolled had the following statistics: average age 62.3±7.1 years, 5 female/15 male, 11 had tumors on the right and 9 on the left and the average tumor size was ∼31.4±10.8 mm. X-ray imaging conditions for the pulse pairs were: 70/120 kVp, 280/221 mA and 65/8 ms. For views where these parameters were insufficient 80/130 kVp, 280/221 mA and 60/12 ms was used. Tumor visibility improved for 0°, 45°, 90° and 135° in 100%, 55%, 75% and 80% of the cases respectively. Tumor shift during a breathing cycle was: 2.4±1.0 mm AP, 2.7±1.4 mm LR and 7.6±4.8 mm IS. Conclusion: DE subtraction fluoroscopy allowed improved visualization and quantification of movement of tumors in the lungs during a breathing cycle. This study was entirely funded by Varian Medical Systems.

  16. Monoplane Stereoscopic Imaging Method for Inverse Geometry X-ray Fluoroscopy.

    Science.gov (United States)

    Tomkowiak, Michael T; Van Lysel, Michael S; Speidel, Michael A

    2013-03-13

    Scanning Beam Digital X-ray (SBDX) is a low-dose inverse geometry fluoroscopic system for cardiac interventional procedures. The system performs x-ray tomosynthesis at multiple planes in each frame period and combines the tomosynthetic images into a projection-like composite image for fluoroscopic display. We present a novel method of stereoscopic imaging using SBDX, in which two slightly offset projection-like images are reconstructed from the same scan data by utilizing raw data from two different detector regions. To confirm the accuracy of the 3D information contained in the stereoscopic projections, a phantom of known geometry containing high contrast steel spheres was imaged, and the spheres were localized in 3D using a previously described stereoscopic localization method. After registering the localized spheres to the phantom geometry, the 3D residual RMS errors were between 0.81 and 1.93 mm, depending on the stereoscopic geometry. To demonstrate visualization capabilities, a cardiac RF ablation catheter was imaged with the tip oriented towards the detector. When viewed as a stereoscopic red/cyan anaglyph, the true orientation (towards vs. away) could be resolved, whereas the device orientation was ambiguous in conventional 2D projection images. This stereoscopic imaging method could be implemented in real time to provide live 3D visualization and device guidance for cardiovascular interventions using a single gantry and data acquired through normal, low-dose SBDX imaging.

  17. Soft X-Ray Imaging Design and Analysis Methods on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Shafer, Morgan W [ORNL; Battaglia, D. J. [Oak Ridge National Laboratory (ORNL); Unterberg, Ezekial A [ORNL; Canik, John [ORNL; Evans, T. E. [General Atomics, San Diego; Harris, Jeffrey H [ORNL; Meitner, Steven J [ORNL

    2011-01-01

    A new tangential 2D Soft X-Ray Imaging System (SXRIS) is being designed to examine the edge magnetic island structure in the lower X-point region of DIII-D. A synthetic diagnostic calculation coupled to 3D emissivity estimates is used to generate phantom images. Phillips-Tikhonov regularization is used to invert the phantom images for comparison to the original emissivity model. Noise level, island size, and equilibrium accuracy are scanned to assess the feasibility of detecting edge island structures. Models of typical DIII-D discharges indicate integration times > 1 ms with accurate equilibrium reconstruction are needed for small island (< 3 cm) detection.

  18. CUDA implementation of histogram stretching function for improving X-ray image.

    Science.gov (United States)

    Lee, Yong H; Kim, Kwan W; Kim, Soon S

    2013-01-01

    This paper presents a method to improve the contrast of digital X-ray image using CUDA program on a GPU. The histogram is commonly used to get the statistical distribution of the contrast in image processing. To increase the visibility of the image in real time, we use the histogram stretching function. It is difficult to implement the function on a GPU because the CUDA program is due to handle the complex process to transfer the source data and the processed results between the memory of GPU and the host system. As a result, we show to operate the histogram stretching function quickly on GPU by the CUDA program.

  19. Characterization of materials for optimal near-infrared and x-ray imaging of the breast.

    Science.gov (United States)

    Michaelsen, Kelly; Krishnaswamy, Venkataramanan; Pogue, Brian W; Brooks, Ken; Defreitas, Ken; Shaw, Ian; Poplack, Steven P; Paulsen, Keith D

    2012-09-01

    Development of a detector case for complete co-registration of images in a non-fiber-based combined near-infrared spectral tomography and digital breast tomosynthesis, required analysis to find materials that could support a breast under full mammographic compression without affecting the x-ray images or the quality of the near infrared measurements. Several possible solutions were considered, and many types of plastics were tested in the development of the detector case. Light channeling within the detector case changed the data obtained in resin and agarose phantoms, lowering recovered absorption values. Additional developments focusing on blocking stray light were successful and permitted a normal subject imaging exam.

  20. Medical physics: some recollections in diagnostic X-ray imaging and therapeutic radiology.

    Science.gov (United States)

    Gray, J E; Orton, C G

    2000-12-01

    Medical physics has changed dramatically since 1895. There was a period of slow evolutionary change during the first 70 years after Roentgen's discovery of x rays. With the advent of the computer, however, both diagnostic and therapeutic radiology have undergone rapid growth and changes. Technologic advances such as computed tomography and magnetic resonance imaging in diagnostic imaging and three-dimensional treatment planning systems, stereotactic radiosurgery, and intensity modulated radiation therapy in radiation oncology have resulted in substantial changes in medical physics. These advances have improved diagnostic imaging and radiation therapy while expanding the need for better educated and experienced medical physics staff.

  1. Application of multivariate statistical analysis to STEM X-ray spectral images: interfacial analysis in microelectronics.

    Science.gov (United States)

    Kotula, Paul G; Keenan, Michael R

    2006-12-01

    Multivariate statistical analysis methods have been applied to scanning transmission electron microscopy (STEM) energy-dispersive X-ray spectral images. The particular application of the multivariate curve resolution (MCR) technique provides a high spectral contrast view of the raw spectral image. The power of this approach is demonstrated with a microelectronics failure analysis. Specifically, an unexpected component describing a chemical contaminant was found, as well as a component consistent with a foil thickness change associated with the focused ion beam specimen preparation process. The MCR solution is compared with a conventional analysis of the same spectral image data set.

  2. Two-dimensional X-ray imaging using plastic scintillating fiber array

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Due to its low cost,flexibility and convenience for long distance dala transfer,plastic scintillation fiber (PSF)have been increasingly used in building detectors or sensors for detecting various radiations and imaging.In this work,the performance of using PSF coupled with charge-coupled devices(CCD)to build are adetectors for 2D X-ray imaging is studied.We describe the experimental setup and show the obtained images from CCD.Modulation Transfer Function(MTF)of the PSF array is also presented and compared to earlier reports.

  3. Development of achromatic full-field x-ray microscopy with compact imaging mirror system

    Science.gov (United States)

    Matsuyama, S.; Emi, Y.; Kino, H.; Sano, Y.; Kohmura, Y.; Tamasaku, K.; Yabashi, M.; Ishikawa, T.; Yamauchi, K.

    2013-09-01

    Compact advanced Kirkpatrick-Baez optics are used to construct a microscope that is easy to align and robust against vibrations and thermal drifts. The entire length of the imaging mirror system is 286 mm, which is 34% shorter than the previous model. A spatial resolution test is performed in which magnified bright-field images of a pattern are taken with an X-ray camera at an energy of 10 keV at the BL29XUL beamline of SPring-8. A line-and-space pattern having a 50- nm width could be resolved, although the image contrast is low.

  4. Human breast cancer in vitro: matching histo-pathology with small-angle x-ray scattering and diffraction enhanced x-ray imaging

    Science.gov (United States)

    Fernández, Manuel; Keyriläinen, Jani; Serimaa, Ritva; Torkkeli, Mika; Karjalainen-Lindsberg, Marja-Liisa; Leidenius, Marjut; von Smitten, Karl; Tenhunen, Mikko; Fiedler, Stefan; Bravin, Alberto; Weiss, Thomas M.; Suortti, Pekka

    2005-07-01

    Twenty-eight human breast tumour specimens were studied with small-angle x-ray scattering (SAXS), and 10 of those were imaged by the diffraction enhanced x-ray imaging (DEI) technique. The sample diameter was 20 mm and the thickness 1 mm. Two examples of ductal carcinoma are illustrated by histology images, DEI, and maps of the collagen d-spacing and scattered intensity in the Porod regime, which characterize the SAXS patterns from collagen-rich regions of the samples. Histo-pathology reveals the cancer-invaded regions, and the maps of the SAXS parameters show that in these regions the scattering signal differs significantly from scattering by the surrounding tissue, indicating a degradation of the collagen structure in the invaded regions. The DEI images show the borders between collagen and adipose tissue and provide a co-ordinate system for tissue mapping by SAXS. In addition, degradation of the collagen structure in an invaded region is revealed by fading contrast of the DEI refraction image. The 28 samples include fresh, defrosted tissue and formalin-fixed tissue. The d-values with their standard deviations are given. In the fresh samples there is a systematic 0.76% increase of the d-value in the invaded regions, averaged over 11 samples. Only intra-sample comparisons are made for the formalin-fixed samples, and with a long fixation time, the difference in the d-value stabilizes at about 0.7%. The correspondence between the DEI images, the SAXS maps and the histo-pathology suggests that definitive information on tumour growth and malignancy is obtained by combining these x-ray methods.

  5. Distal radius bone mineral density estimation using the filling factor of trabecular bone in the x-ray image.

    Science.gov (United States)

    Lee, Sooyeul; Jeong, Ji-Wook; Lee, Jeong Won; Yoo, Done-Sik; Kim, Seunghwan

    2006-01-01

    Osteoporosis is characterized by an abnormal loss of bone mineral content, which leads to a tendency to non-traumatic bone fractures or to structural deformations of bone. Thus, bone density measurement has been considered as a most reliable method to assess bone fracture risk due to osteoporosis. In past decades, X-ray images have been studied in connection with the bone mineral density estimation. However, the estimated bone mineral density from the X-ray image can undergo a relatively large accuracy or precision error. The most relevant origin of the accuracy or precision error may be unstable X-ray image acquisition condition. Thus, we focus our attentions on finding a bone mineral density estimation method that is relatively insensitive to the X-ray image acquisition condition. In this paper, we develop a simple technique for distal radius bone mineral density estimation using the trabecular bone filling factor in the X-ray image and apply the technique to the wrist X-ray images of 20 women. Estimated bone mineral density shows a high linear correlation with a dual-energy X-ray absorptiometry (r=0.87).

  6. Femtosecond Diffractive Imaging with a Soft-X-ray Free-Electron Laser

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, H N; Barty, A; Bogan, M; Boutet, S; Frank, M; Hau-Riege, S P; Marchesini, S; Woods, B; Bajt, S; Benner, W H; London, R; Ploenjes-Palm, E; Kuhlmann, M; Treusch, R; Dusterer, S; Tschentscher, T; Schneider, J; Spiller, E; Moller, T; Bostedt, C; Hoener, M; Shapiro, D; Hodgson, K O; der Spoel, D v; Burmeister, F; Bergh, M; Caleman, C; Huldt, G; Seibert, M; Maia, F; Lee, R; Szoke, A; Timneanu, N; Hajdu, J

    2006-03-13

    Theory predicts that with an ultrashort and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. Here we report the first experimental demonstration of this principle using the FLASH soft X-ray free-electron laser. An intense 25 fs, 4 x 10{sup 13} W/cm{sup 2} pulse, containing 10{sup 12} photons at 32 nm wavelength, produced a coherent diffraction pattern from a nano-structured non-periodic object, before destroying it at 60,000 K. A novel X-ray camera assured single photon detection sensitivity by filtering out parasitic scattering and plasma radiation. The reconstructed image, obtained directly from the coherent pattern by phase retrieval through oversampling, shows no measurable damage, and extends to diffraction-limited resolution. A three-dimensional data set may be assembled from such images when copies of a reproducible sample are exposed to the beam one by one.

  7. Femtosecond Diffractive Imaging with a Soft-X-Ray Free-Electron Laser

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, Henry N.; /LLNL, Livermore /UC, Davis; Barty, Anton: AUTHOR = Bogan, Michael J.; /LLNL, Livermore; Boutet, Sebastian; /LLNL, Livermore /SLAC /Uppsala U., Biomed. Ctr.; Frank, Matthias; Hau-Riege, Stefan P.; /LLNL, Livermore; Marchesini, Stefano; /LLNL, Livermore /UC, Davis; Woods, Bruce W.; Bajt, Sasa; Benner, W.Henry; /LLNL, Livermore; London, Richard A.; /LLNL, Livermore /UC, Davis; Plonjes, Elke; Kuhlmann, Marion; Treusch, Rolf; Dusterer, Stefan; Tschentscher, Thomas; Schneider, Jochen R.; /CERN; Spiller, Eberhard; /Spiller X-ray Optics, Livermore; Moller, Thomas; Bostedt, Christoph; Hoener, Matthias; /Berlin, Tech. U.; Shapiro, David A.; /UC, Davis /SLAC /Uppsala U. /LLNL, Livermore /Uppsala U. /Uppsala U. /SLAC /Uppsala U.

    2010-10-07

    Theory predicts that with an ultrashort and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. Here we report the first experimental demonstration of this principle using the FLASH soft X-ray free-electron laser. An intense 25 fs, 4 x 10{sup 13} W/cm{sup 2} pulse, containing 10{sup 12} photons at 32 nm wavelength, produced a coherent diffraction pattern from a nano-structured non-periodic object, before destroying it at 60,000 K. A novel X-ray camera assured single photon detection sensitivity by filtering out parasitic scattering and plasma radiation. The reconstructed image, obtained directly from the coherent pattern by phase retrieval through oversampling, shows no measurable damage, and extends to diffraction-limited resolution. A three-dimensional data set may be assembled from such images when copies of a reproducible sample are exposed to the beam one by one.

  8. Quantifying Substructure Measures In X-ray Images of Galaxy Cluster Mergers With SLAM

    Science.gov (United States)

    Chatzikos, Marios; Sarazin, C. L.; O'Shea, B. W.

    2014-01-01

    I use the Simulation Library of Astrophysical galaxy cluster Mergers (SLAM) database to quantify the effects of mergers on X-ray observables. SLAM consists of a set of 156 adiabatic simulations of binary galaxy cluster mergers, that covers 2 orders of magnitude in the mass of the primary cluster, four values for the mass contrast, and four values for the angular momentum of the collision. In this talk I describe results on substructure measures obtained for various viewing angles. I have quantified the substructure in X-ray images using both center shifts and power ratios. Mergers of intermediate mass contrasts produce substructure signals that can persist in X-ray images for at least 1-2 sound crossing times. The amplitude of both measures depends strongly on the initial mass contrast. The measures for major mergers (mass contrast less than 3) appear to depend on the system mass, while for minor mergers (mass contrast between 3 and 10) they are generally independent of the system mass. Neither measure reflects the true dynamical state of the system closely, although the center shifts appear to be a better proxy. Comparisons with the virial and hydrostatic disequilibrium parameters reveal that there is no value of either substructure measure that unambiguously distinguishes merging from relaxing systems. Implications for SZE observations will also be discussed.

  9. Transmission x-ray microscopy at Diamond-Manchester I13 Imaging Branchline

    Science.gov (United States)

    Vila-Comamala, Joan; Bosgra, Jeroen; Eastwood, David S.; Wagner, Ulrich; Bodey, Andrew J.; Garcia-Fernandez, Miryam; David, Christian; Rau, Christoph

    2016-01-01

    Full-field Transmission X-ray Microscopy (TXM) has been shown to be a powerful method for obtaining quantitative internal structural and chemical information from materials at the nanoscale. The installation of a Full-field TXM station will extend the current microtomographic capabilities of the Diamond-Manchester I13 Imaging Branchline at Diamond Light Source (UK) into the sub-100 nm spatial resolution range using photon energies from 8 to 14 keV. The dedicated Full-field TXM station will be built in-house with contributions of Diamond Light Source support divisions and via collaboration with the X-ray Optics Group of Paul Scherrer Institut (Switzerland) which will develop state-of-the-art diffractive X-ray optical elements. Preliminary results of the I13 Full-field TXM station are shown. The Full-field TXM will become an important Diamond Light Source direct imaging asset for material science, energy science and biology at the nanoscale.

  10. Transmission x-ray microscopy at Diamond-Manchester I13 Imaging Branchline

    Energy Technology Data Exchange (ETDEWEB)

    Vila-Comamala, Joan, E-mail: joan.vila.comamala@gmail.com; Wagner, Ulrich; Bodey, Andrew J.; Garcia-Fernandez, Miryam; Rau, Christoph [Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE (United Kingdom); Bosgra, Jeroen; David, Christian [Paul Scherrer Institut, 5232 PSI-Villigen (Switzerland); Eastwood, David S. [Manchester X-ray Imaging Facility, School of Materials, University of Manchester, Manchester M13 9PL, UK and Research Complex at Harwell, Harwell Campus, Didcot OX11 0FA (United Kingdom)

    2016-01-28

    Full-field Transmission X-ray Microscopy (TXM) has been shown to be a powerful method for obtaining quantitative internal structural and chemical information from materials at the nanoscale. The installation of a Full-field TXM station will extend the current microtomographic capabilities of the Diamond-Manchester I13 Imaging Branchline at Diamond Light Source (UK) into the sub-100 nm spatial resolution range using photon energies from 8 to 14 keV. The dedicated Full-field TXM station will be built in-house with contributions of Diamond Light Source support divisions and via collaboration with the X-ray Optics Group of Paul Scherrer Institut (Switzerland) which will develop state-of-the-art diffractive X-ray optical elements. Preliminary results of the I13 Full-field TXM station are shown. The Full-field TXM will become an important Diamond Light Source direct imaging asset for material science, energy science and biology at the nanoscale.

  11. Characterization of the imaging performance of the simultaneously counting and integrating X-ray detector CIX

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Johannes

    2010-01-15

    The CIX detector is a direct converting hybrid pixel detector designed for medical X-ray imaging applications. Its de ning feature is the simultaneous operation of a photon counter as well as an integrator in every pixel cell. This novel approach o ers a dynamic range of more than five orders of magnitude, as well as the ability to directly obtain the average photon energy from the measured data. Several CIX 0.2 ASICs have been successfully connected to CdTe, CdZnTe and Si sensors. These detector modules were tested with respect to the imaging performance of the simultaneously counting and integrating concept under X-ray irradiation. Apart from a characterization of the intrinsic benefits of the CIX concept, the sensor performance was also investigated. Here, the two parallel signal processing concepts offer valuable insights into material related effects like polarization and temporal response. The impact of interpixel coupling effects like charge-sharing, Compton scattering and X-ray fluorescence was evaluated through simulations and measurements. (orig.)

  12. Advancements in X-ray waveguides and their applications in coherent diffraction imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pelliccia, D. [Institut fuer Synchrotronstrahlung-ANKA Forschungszentrum Karlsruhe Herman-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)], E-mail: daniele.pelliccia@iss.fzk.de; Bukreeva, I. [Istituto di Fotonica e Nanotecnologie-CNR, Via Cineto Romano 42, 00156 Roma (Italy); Giannini, C.; De Caro, L. [Istituto di Cristallografia-CNR, Via Amendola 122/O, 70126 Bari (Italy); Cedola, A.; Scarinci, F.; Lagomarsino, S. [Istituto di Fotonica e Nanotecnologie-CNR, Via Cineto Romano 42, 00156 Roma (Italy)

    2009-10-15

    X-ray planar waveguides are currently used tools, in synchrotron radiation facilities, to produce a coherent beam with typical dimensions in the range of tens or hundreds of nanometers. The properties of waveguided beams such as divergence and coherence turns out to be very interesting for several applications both in synchrotron and in laboratory sources. These features will be reviewed in the present paper for different coupling methods of the radiation field with the waveguide channel. Details of fabrication procedures and experimental results concerning front coupling waveguide are reported. The waveguide properties can be estimated from the far-field diffracted beam by a Fourier analysis giving the autocorrelation function of the exit field. Due to the high degree of coherence of the exiting beam, X-ray waveguides can be successfully exploited in coherent diffraction imaging experiments. We review results concerning Fresnel coherent diffraction imaging experiments with hard X-rays, using planar waveguides as optical elements in one and two dimensions.

  13. Performance and limitations of high granularity single photon processing X-ray imaging detectors

    CERN Document Server

    Tlustos, L

    2005-01-01

    Progress in CMOS technology and in fine pitch bump bonding has made possible the development of single photon counting detectors for X-ray imaging with pixel pitches on the order of 50 µm giving a spatial resolution which is comparable to conventional CCD and flat panel detectors. This thesis studies the interaction of X-ray photons in the energy range of 5 keV to 70 keV with various sensor materials as well as the response of the Medipix2 readout system to both monochromatic and wide spectrum X-ray sources. Single photon processing offers the potential for spectroscopic imaging. However, this thesis demonstrates using simulations and measurements that the charge deposition and collection within the semiconductor sensor impose fundamental limits on the achievable energy resolution. In particular the discussion of charge during collection in the sensor and the generation of fluorescence photons in heavier sensor materials contribute to the appearance of a low energy tail on the detected spectrum of an incomin...

  14. Equation-of-State Measurements of Resorcinol Formaldehyde Foam Using Imaging X-Ray Thomson Spectrometer

    Science.gov (United States)

    Belancourt, Patrick; Theobald, W.; Keiter, P. A.; Collins, T. J. B.; Bonino, M. J.; Kozlowski, P.; Drake, R. P.

    2015-11-01

    Understanding the equation of state of materials under shocked conditions is important for laboratory astrophysics and high-energy-density physics experiments. This talk will focus on experiments dedicated to developing a platform for measuring the equation of state of shocked foams on OMEGA EP. The foam used in the development of this platform is resorcinol formaldehyde foam with an initial density of 0.34 g/cc. One OMEGA EP beam drives a shock into the foam, while the remaining three beams irradiate a nickel foil to create the x-ray backlighter. The primary diagnostic for this platform, the imaging x-ray Thomson spectrometer (IXTS), spectrally resolves the scattered x-ray beam while imaging in one spatial dimension. The IXTS is ideally suited to measure plasma conditions upstream, downstream and at the shock front in the foam. Preliminary results from these experiments will be shown. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944, the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas DE-NA0001840, and by the National Laser User Facility Program DE-NA0000850.

  15. X-ray Imaging of MagLIF Experiments Using a Spherically-Bent Crystal Optic

    Science.gov (United States)

    Harding, E. C.; Gomez, M. R.; Jennings, C. A.; Knapp, P. F.; Slutz, S. A.; Sefkow, A. B.; Awe, T. J.; Hansen, S. B.; Peterson, K. J.; Hahn, K. D.; McBride, R. D.; Rochau, G. A.; Sinars, D. B.; Golovkin, I.

    2015-11-01

    The recent Magnetized Liner Inertial Fusion (MagLIF) experiments performed on Sandia's Z-machine produced significant thermonuclear DD fusion yields that were accompanied by observable x-ray emission [M.R. Gomez et. al., PRL (2014)]. The MagLIF experiments relied on a spherically-bent crystal optic to image portions of the x-ray continuum that were generated by the hot stagnation plasma. The images of stagnation show a long (6 to 8 mm) and narrow (~100 micron) column of x-ray emission with structure in both directions. This structure may be caused by variations in the electron temperature (Te) and density (ne) , as well as opacity variations in the surrounding Be pusher. Here we investigate the possible contributions from each of these effects. We will also discuss the development of a diagnostic technique in which Te and ne of the DD fuel are inferred from spectra emitted by Fe impurities that become ionized to a He-like charge state. Sandia National Labs is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. DoE NNSA under contract DE-AC04-94AL85000.

  16. X-ray imaging with GEMs using $100\\,\\mu$m thick foils

    CERN Document Server

    da Luz, H Natal; Carvalho, X; Santos, J M F dos

    2013-01-01

    A simple X-ray imaging system using off-the-shelf electronics and simple reconstruction algorithms aiming a spatial resolution of 1.7 mm ($\\sim 3%$ of the detector length) is described in this work. For this, two 100 cm$^2$ Gas Electron Multiplier (GEM) foils with a thickness of $100\\,\\mu$m (2-fold thicker than the standard ones) were immersed in a mixture of argon and carbon dioxide (70:30). The charge readout with 2D position determination was done with resistive charge division. Thicker foils reach higher electron multiplication than the standard GEM, easily reaching charge gains in excess of 10$^4$, when operated in a double GEM cascade configuration. Furthermore, the $100 \\mu$m thick GEM foils were found to be less prone to damage caused by electrical discharges. X-ray images are shown and some descriptions of the physical processes involved are presented. We describe the advantages of this method that allows counting each X-ray photon or particle entering the detector, its interaction position, as well ...

  17. Feasibility Study of Gas Electron Multiplier Detector as an X-Ray Image Sensor

    CERN Document Server

    Shin, Sukyoung; Lee, Soonhyouk

    2015-01-01

    For its ease manufacturing, flexible geometry, and cheap manufacturing cost, the gas electron multiplier (GEM) detector can be used as an x-ray image sensor. For this purpose, we acquired relative detection efficiencies and suggested a method to increase the detection efficiency in order to study the possibility of GEM detector as an x-ray image sensor. The GEM detector system is composed of GEM foils, the instrument system, the gas system, and the negative power supply. The instrument system consists of the A225 charge sensitive preamp, A206 discriminator, and MCA8000D multichannel analyzer. For the gas system, Argon gas was mixed with CO2 to the ratio of 8:2, and for the negative 2,000 volts, the 3106D power supply was used. The CsI-coated GEM foil was used to increase the detection efficiency. Fe-55 was used as an x-ray source and the relative efficiency was acquired by using the ratio of GEM detector to the CdTe detector. The total count method and the energy spectrum method were used to calculate the rel...

  18. Velocimetry in both phases of a cavitating flow by fast X-ray imaging

    Science.gov (United States)

    Coutier-Delgosha, Olivier; Khlifa, Ilyass; Fuzier, Sylvie; Vabre, Alexandre; Fezzaa, Kamel; Marko, Hocevar

    2014-11-01

    A promising method to measure velocity fields in a cavitating flow is presented. Dynamics of the liquid phase and of the bubbles are both investigated. The measurements are based on ultra fast X-ray imaging performed at the APS (Advanced Photon Source) of the Argonne National Laboratory. The experimental device consists of a millimetric Venturi test section associated with a transportable hydraulic loop. Various configurations of velocity, pressure, and temperature have been investigated. Radio-opaque particles are used as tracers for the liquid phase, in association with a multi-pixels sensor to record the successive positions of the particles. The use of X-rays instead of light solves the problem of light reflection and dispersion on phase boundaries, since X-rays penetrate a gas/liquid flow in straight lines. Images contain simultaneously the information related to the particles (for PIV analysis in the liquid), to the vapor bubbles (for PIV in the gas). The slip velocity between vapor and liquid is calculated everywhere both velocities can be obtained.

  19. Femtosecond Diffractive Imaging with a Soft-X-ray Free-Electron Laser

    CERN Document Server

    Chapman, H N; Barty, A; Benner, W H; Bergh, M; Bogan, M J; Bostedt, C; Boutet, S; Burmeister, F; Caleman, C; Düsterer, S; Frank, M; Hajdu, J; Hau-Riege, S P; Hodgson, K O; Hoener, M; Huldt, G; Kuhlmann, M; Lee, R W; London, R A; Maia, F R N C; Marchesini, S; Möller, T; Plonjes, E; Schneider, J R; Seibert, M M; Shapiro, D A; Spiller, E; Szoke, A; Timneanu, N; Treusch, R; Tschentscher, T; Van der Spoel, D; Woods, B W; Bajt, Sasa; Barty, Anton; Bergh, Magnus; Bogan, Michael J.; Bostedt, Christoph; Boutet, Sebastien; Burmeister, Florian; Caleman, Carl; Chapman, Henry N.; Dusterer, Stefan; Frank, Matthias; Hajdu, Janos; Hau-Riege, Stefan P.; Hodgson, Keith O.; Hoener, Matthias; Huldt, Gosta; Kuhlmann, Marion; Lee, Richard W.; London, Richard A.; Maia, Filipe R.N.C.; Marchesini, Stefano; Moller, Thomas; Plonjes, Elke; Schneider, Jochen R.; Shapiro, David A.; Spiller, Eberhard; Spoel, David van der; Szoke, Abraham; Timneanu, Nicusor; Treusch, Rolf; Tschentscher, Thomas; Woods, Bruce W.

    2006-01-01

    Theory predicts that with an ultrashort and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. Here we report the first experimental demonstration of this principle using the FLASH soft X-ray free-electron laser. An intense 25 fs, 4 10^13 W/cm^2 pulse, containing 10^12 photons at 32 nm wavelength, produced a coherent diffraction pattern from a nano-structured non-periodic object, before destroying it at 60,000 K. A novel X-ray camera assured single photon detection sensitivity by filtering out parasitic scattering and plasma radiation. The reconstructed image, obtained directly from the coherent pattern by phase retrieval through oversampling, shows no measurable damage, and extends to diffraction-limited resolution. A three-dimensional data set may be assembled from such images when copies of a reproducible sample are exposed to the beam one by one.

  20. Toroidal and poloidal soft x-ray imaging system on the DIII-D tokamak

    Science.gov (United States)

    Snider, R. T.; Evanko, R.; Haskovec, J.

    1988-08-01

    A toroidal soft x-ray imaging system is being added to the currently installed poloidal soft x-ray system on the DIII-D tokamak. The poloidal array is used to determine the poloidal mode structure and location of internal helical MHD perturbations in the plasma. The new array will add toroidal mode identification capability. The four detector arrays are toroidally spaced in a manner that allows identification of toroidal mode numbers up to 24. Beryllium vacuum windows separate the detectors from the tokamak vacuum and also serve as low-energy filters. The separate detector vacuum chambers can be filled with a gas that changes the low-energy cutoff of the system. By proper selection of the gas and pressure the low-energy cutoff can be chosen over the entire range of the detector sensitivity (500-1200 eV). This capability can be used to produce crude x-ray spectra for the entire imaging system or for gain control.

  1. Toroidal and poloidal soft X-ray imaging system on the D3-D tokamak

    Science.gov (United States)

    Snider, R.; Evanko, R.; Haskovec, J.

    1988-02-01

    A toroidal soft X-ray imaging system is being added to the currently installed poloidal soft X-ray system on the D3-D tokamak. The poloidal array is used to determine the poloidal mode structure and location of internal helical MHD perturbations in the plasma. The new array will add toroidal mode identification capability. The four detector arrays are toroidally spaced in a manner which allows identification of toroidal mode numbers of up to 24. Beryllium vacuum windows separate the detectors from the tokamak vacuum and also serve as low energy filters. The separate detector vacuum chambers can be filled with a gas which changes the low energy cutoff of the system. By proper selection of the gas and pressure the low energy cutoff can be chosen over the entire range of the detector sensitivity (500 eV to 1200 eV). This capability can be used to produce crude X-ray spectra for the entire imaging system or for gain control.

  2. Elemental characterisation of melanin in feathers via synchrotron X-ray imaging and absorption spectroscopy

    Science.gov (United States)

    Edwards, Nicholas P.; van Veelen, Arjen; Anné, Jennifer; Manning, Phillip L.; Bergmann, Uwe; Sellers, William I.; Egerton, Victoria M.; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Wakamatsu, Kazumasa; Ito, Shosuke; Wogelius, Roy A.

    2016-09-01

    Melanin is a critical component of biological systems, but the exact chemistry of melanin is still imprecisely known. This is partly due to melanin’s complex heterogeneous nature and partly because many studies use synthetic analogues and/or pigments extracted from their natural biological setting, which may display important differences from endogenous pigments. Here we demonstrate how synchrotron X-ray analyses can non-destructively characterise the elements associated with melanin pigment in situ within extant feathers. Elemental imaging shows that the distributions of Ca, Cu and Zn are almost exclusively controlled by melanin pigment distribution. X-ray absorption spectroscopy demonstrates that the atomic coordination of zinc and sulfur is different within eumelanised regions compared to pheomelanised regions. This not only impacts our fundamental understanding of pigmentation in extant organisms but also provides a significant contribution to the evidence-based colour palette available for reconstructing the appearance of fossil organisms.

  3. Fast scattering simulation tool for multi-energy x-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sossin, A., E-mail: artur.sossin@cea.fr [CEA-LETI MINATEC Grenoble, F-38054 Grenoble (France); Tabary, J.; Rebuffel, V. [CEA-LETI MINATEC Grenoble, F-38054 Grenoble (France); Létang, J.M.; Freud, N. [Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Claude Bernard Lyon 1, Centre Léon Bérard (France); Verger, L. [CEA-LETI MINATEC Grenoble, F-38054 Grenoble (France)

    2015-12-01

    A combination of Monte Carlo (MC) and deterministic approaches was employed as a means of creating a simulation tool capable of providing energy resolved x-ray primary and scatter images within a reasonable time interval. Libraries of Sindbad, a previously developed x-ray simulation software, were used in the development. The scatter simulation capabilities of the tool were validated through simulation with the aid of GATE and through experimentation by using a spectrometric CdTe detector. A simple cylindrical phantom with cavities and an aluminum insert was used. Cross-validation with GATE showed good agreement with a global spatial error of 1.5% and a maximum scatter spectrum error of around 6%. Experimental validation also supported the accuracy of the simulations obtained from the developed software with a global spatial error of 1.8% and a maximum error of around 8.5% in the scatter spectra.

  4. Design and performance of an imaging plate system for X-ray diffraction study

    Science.gov (United States)

    Amemiya, Yoshiyuki; Matsushita, Tadashi; Nakagawa, Atsushi; Satow, Yoshinori; Miyahara, Junji; Chikawa, Jun-ichi

    1988-04-01

    A new readout system for a BaFBr: Eu 2+ photostimulable phosphor screen (imaging plate) was constructed by modifying a drum scanner, with a design optimized for X-ray diffraction and scattering applications. An effort was made to achieve a high detective quantum efficiency below 20 keV, a small pixel size (25 μm × 25 μm), a low quantization noise (0.22%) using 12-bit A/D converters, and the capability to cover an inherent dynamic range (1:10 5) of the photostimulated luminescence by using two photomultiplier tubes. This system is being used in several synchrotron radiation experiments: Laue diffraction of protein crystals, small angle diffraction from a single muscle fiber, powder diffraction from crystals in a diamond anvil cell, and time-resolved small-angle X-ray scattering from a synthetic polymer during stretching.

  5. Sorting algorithms for single-particle imaging experiments at X-ray free-electron lasers.

    Science.gov (United States)

    Bobkov, S A; Teslyuk, A B; Kurta, R P; Gorobtsov, O Yu; Yefanov, O M; Ilyin, V A; Senin, R A; Vartanyants, I A

    2015-11-01

    Modern X-ray free-electron lasers (XFELs) operating at high repetition rates produce a tremendous amount of data. It is a great challenge to classify this information and reduce the initial data set to a manageable size for further analysis. Here an approach for classification of diffraction patterns measured in prototypical diffract-and-destroy single-particle imaging experiments at XFELs is presented. It is proposed that the data are classified on the basis of a set of parameters that take into account the underlying diffraction physics and specific relations between the real-space structure of a particle and its reciprocal-space intensity distribution. The approach is demonstrated by applying principal component analysis and support vector machine algorithms to the simulated and measured X-ray data sets.

  6. Influence of metal screens on contrast in megavoltage x-ray imaging.

    Science.gov (United States)

    Droege, R T; Bjärngard, B E

    1979-01-01

    The radiographic contrast of metal screen-film detectors was investigated in order to determine the contrast capabilities of these detectors applied to megavoltage x-ray imaging. The film contrast gamma was found to be independent of the metal screen composition. Measurement of the scatter-to-primary film dose ratio in contact geometry demonstrated that a thick front screen of either 1.5 g/cm2 copper of 2.5 g/cm2 lead provides optimum contrast for the photon energies studied (60Co and 4- and 8-MV x rays). The same thickness were also found to be suitable in an air gap geometry which significantly improved the contrast compared to the contact geometry. Rear lead screens were found to provide no contrast improvement.

  7. An integrating CMOS APS for X-ray imaging with an in-pixel preamplifier

    Science.gov (United States)

    Abdalla, M. A.; Fröjdh, C.; Petersson, C. S.

    2001-06-01

    We present in this paper an integrating CMOS Active Pixel Sensor (APS) circuit coated with scintillator type sensors for intra-oral dental X-ray imaging systems. The photosensing element in the pixel is formed by the p-diffusion on the n-well diode. The advantage of this photosensor is its very low direct absorption of X-rays compared to the other available photosensing elements in the CMOS pixel. The pixel features an integrating capacitor in the feedback loop of a preamplifier of a finite gain in order to increase the optical sensitivity. To verify the effectiveness of this in-pixel preamplification, a prototype 32×80 element CMOS active pixel array was implemented in a 0.8 μm CMOS double poly, n-well process with a pixel pitch of 50 μm. Measured results confirmed the improved optical sensitivity performance of the APS. Various measurements on device performance are presented.

  8. Elemental characterisation of melanin in feathers via synchrotron X-ray imaging and absorption spectroscopy

    Science.gov (United States)

    Edwards, Nicholas P.; van Veelen, Arjen; Anné, Jennifer; Manning, Phillip L.; Bergmann, Uwe; Sellers, William I.; Egerton, Victoria M.; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Wakamatsu, Kazumasa; Ito, Shosuke; Wogelius, Roy A.

    2016-01-01

    Melanin is a critical component of biological systems, but the exact chemistry of melanin is still imprecisely known. This is partly due to melanin’s complex heterogeneous nature and partly because many studies use synthetic analogues and/or pigments extracted from their natural biological setting, which may display important differences from endogenous pigments. Here we demonstrate how synchrotron X-ray analyses can non-destructively characterise the elements associated with melanin pigment in situ within extant feathers. Elemental imaging shows that the distributions of Ca, Cu and Zn are almost exclusively controlled by melanin pigment distribution. X-ray absorption spectroscopy demonstrates that the atomic coordination of zinc and sulfur is different within eumelanised regions compared to pheomelanised regions. This not only impacts our fundamental understanding of pigmentation in extant organisms but also provides a significant contribution to the evidence-based colour palette available for reconstructing the appearance of fossil organisms. PMID:27658854

  9. Imaging interfacial micro- and nano-bubbles by scanning transmission soft X-ray microscopy.

    Science.gov (United States)

    Zhang, Lijuan; Zhao, Binyu; Xue, Lian; Guo, Zhi; Dong, Yaming; Fang, Haiping; Tai, Renzhong; Hu, Jun

    2013-05-01

    Synchrotron-based scanning transmission soft X-ray microscopy (STXM) with nanometer resolution was used to investigate the existence and behavior of interfacial gas nanobubbles confined between two silicon nitride windows. The observed nanobubbles of SF6 and Ne with diameters smaller than 2.5 µm were quite stable. However, larger bubbles became unstable and grew during the soft X-ray imaging, indicating that stable nanobubbles may have a length scale, which is consistent with a previous report using atomic force microscopy [Zhang et al. (2010), Soft Matter, 6, 4515-4519]. Here, it is shown that STXM is a promising technique for studying the aggregation of gases near the solid/water interfaces at the nanometer scale.

  10. X-ray imaging and 3D reconstruction of in-flight exploding foil initiator flyers

    Science.gov (United States)

    Willey, T. M.; Champley, K.; Hodgin, R.; Lauderbach, L.; Bagge-Hansen, M.; May, C.; Sanchez, N.; Jensen, B. J.; Iverson, A.; van Buuren, T.

    2016-06-01

    Exploding foil initiators (EFIs), also known as slapper initiators or detonators, offer clear safety and timing advantages over other means of initiating detonation in high explosives. This work outlines a new capability for imaging and reconstructing three-dimensional images of operating EFIs. Flyer size and intended velocity were chosen based on parameters of the imaging system. The EFI metal plasma and plastic flyer traveling at 2.5 km/s were imaged with short ˜80 ps pulses spaced 153.4 ns apart. A four-camera system acquired 4 images from successive x-ray pulses from each shot. The first frame was prior to bridge burst, the 2nd images the flyer about 0.16 mm above the surface but edges of the foil and/or flyer are still attached to the substrate. The 3rd frame captures the flyer in flight, while the 4th shows a completely detached flyer in a position that is typically beyond where slappers strike initiating explosives. Multiple acquisitions at different incident angles and advanced computed tomography reconstruction algorithms were used to produce a 3-dimensional image of the flyer at 0.16 and 0.53 mm above the surface. Both the x-ray images and the 3D reconstruction show a strong anisotropy in the shape of the flyer and underlying foil parallel vs. perpendicular to the initiating current and electrical contacts. These results provide detailed flyer morphology during the operation of the EFI.

  11. Impact of miscentering on patient dose and image noise in x-ray CT imaging : Phantom and clinical studies

    NARCIS (Netherlands)

    Habibzadeh, M. A.; Ay, M. R.; Asl, A. R. Kamali; Ghadiri, H.; Zaidi, H.

    2012-01-01

    The operation of the bowtie filter in x-ray CT is correct if the object being scanned is properly centered in the scanner's field-of-view. Otherwise, the dose delivered to the patient and image noise will deviate from optimal setting. We investigate the effect of miscentering on image noise and surf

  12. Single-shot x-ray differential phase-contrast and diffraction imaging using two-dimensional transmission gratings.

    Science.gov (United States)

    Wen, Harold H; Bennett, Eric E; Kopace, Rael; Stein, Ashley F; Pai, Vinay

    2010-06-15

    We describe an x-ray differential phase-contrast imaging method based on two-dimensional transmission gratings that are directly resolved by an x-ray camera. X-ray refraction and diffraction in the sample lead to variations of the positions and amplitudes of the grating fringes on the camera. These effects can be quantified through spatial harmonic analysis. The use of 2D gratings allows differential phase contrast in several directions to be obtained from a single image. When compared to previous grating-based interferometry methods, this approach obviates the need for multiple exposures and separate measurements for different directions and thereby accelerates imaging speed.

  13. Femtosecond Single-Shot Imaging of Nanoscale Ferromagnetic Order in Co/Pd Multilayers using Resonant X-ray Holography

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Tianhan; Zhu, Diling; Benny Wu,; Graves, Catherine; Schaffert, Stefan; Rander, Torbjorn; Muller, leonard; Vodungbo, Boris; Baumier, Cedric; Bernstein, David P.; Brauer, Bjorn; Cros, Vincent; Jong, Sanne de; Delaunay, Renaud; Fognini, Andreas; Kukreja, Roopali; Lee, Sooheyong; Lopez-Flores, Victor; Mohanty, Jyoti; Pfau, Bastian; Popescu, 5 Horia

    2012-05-15

    We present the first single-shot images of ferromagnetic, nanoscale spin order taken with femtosecond x-ray pulses. X-ray-induced electron and spin dynamics can be outrun with pulses shorter than 80 fs in the investigated fluence regime, and no permanent aftereffects in the samples are observed below a fluence of 25 mJ/cm{sup 2}. Employing resonant spatially-muliplexed x-ray holography results in a low imaging threshold of 5 mJ/cm{sup 2}. Our results open new ways to combine ultrafast laser spectroscopy with sequential snapshot imaging on a single sample, generating a movie of excited state dynamics.

  14. Synchrotron ultra-fast X-ray imaging of a cavitating flow in a Venturi profile

    Science.gov (United States)

    Vabre, A.; Gmar, M.; Lazaro, D.; Legoupil, S.; Coutier, O.; Dazin, A.; Lee, W. K.; Fezzaa, K.

    2009-08-01

    Cavitation consists of successive vaporization and condensation processes in a liquid flow, due to a large pressure decrease usually associated with sudden flow acceleration. This phenomenon occurs typically in pumps and naval propellers, on the blades' suction side and/or in periphery of the rotor. It is associated with performance decrease, blade erosion, vibrations that may lead to damage, and noise due to vapor collapse close to the solid walls. Therefore, a general understanding of the mechanisms that govern flow vaporization and condensation is of the utmost importance to reduce or at least to control these effects. A major issue is to estimate velocity fields in both phases, i.e. liquid and vapor. These combined measurements are missing in the literature. We propose a method of ultra-fast X-ray imaging to cope this lack. This method is based on X-ray absorption and phase-contrast enhancement. This technique can simultaneously measure the flow velocities of both liquid and vapor phases at kHz frequency. For the X-ray measurements, a dedicated Venturi shape canal has been designed for the experiments. The design is based on a known two-phase flows hydraulic set-up. The studied cavitation occurs downstream from the Venturi profile. The experiments were carried out at the Advanced Photon Source (APS) at Argonne National Laboratory. These experiments have confirmed the advantages of ultra-fast X-ray imaging for the visualization of liquid-vapor interfaces. Also, the feasibility of estimating velocity field in the flow is acknowledged.

  15. Investigation of Backscatter X-ray imaging techniques for Uranium Dioxide Fuel Rods

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Timothy D [Rensselaer Polytechnic Institute (RPI); Hollenbach, Daniel F [ORNL; Shedlock, Daniel [Nucsafe, Inc.

    2011-01-01

    Radiography by Selective Detection (RSD), was investigated for its ability to determine the presence and types of defects in a UO{sub 2} fuel rod surrounded by zirconium cladding. Images created using a Monte Carlo model compared favorably with actual X-ray backscatter images from mock fuel rods. A fuel rod was modeled as a rectangular parallelepiped with zirconium cladding, and pencil beam X-ray sources of 160 kVp (79 keV avg) and 480 kVp (218 keV avg) were generated using the Monte Carlo N-Particle Transport Code to attempt to image void and palladium (Pd) defects in the interior and on the surface of the fuel pellet. It was found that the 160 kVp spectrum was unable to detect the presence of interior defects, whereas the 480 kVp spectrum detected them with both the standard and the RSD backscatter methods, though the RSD method was very inefficient. It was also found that both energy spectra were able to detect void and Pd defects on the surface using both imaging methods. Additionally, two mock fuel rods were imaged using a backscatter X-ray imaging system, one consisting of hafnium pellets in a Zircaloy-4 cladding and the other consisting of steel pellets in a Zircalloy-4 cladding which was then encased in a steel cladding (a double encapsulation configuration employed in irradiation and experiments). It was found that the system was capable of detecting individual HfO{sub 2} pellets in a Zircaloy-4 cladding and may be capable of detecting individual steel pellets in the double-encapsulated sample. It is expected that the system would also be capable of detecting individual UO{sub 2} pellets in a Zircaloy-4 cladding, though no UO{sub 2} fuel rod was available for imaging.

  16. X-ray optical system for imaging laser plumes with a spatial resolution of up to 70 nm

    Science.gov (United States)

    Nechai, A. N.; Pestov, A. E.; Polkovnikov, V. N.; Salashchenko, N. N.; Toropov, M. N.; Chkhalo, N. I.; Tsybin, N. N.; Shcherbakov, A. V.

    2016-04-01

    We consider an X-ray optical system which permits obtaining laser plume images at a wavelength of 13.5 nm with a resolution of up to 70 nm. The X-ray optical system comprises an X-ray Schwarzschild objective made up of two aspherical multilayer mirrors, a scintillator (YAG : Ce ceramics), which converts X-rays to the visible radiation, and a visible-optical system, which images the scintillator surface onto a CCD camera. The spatial resolution of the system is limited by the resolution of the optical system (0.7 μm) and the magnification (10×) of the X-ray objective and is as high as 70 nm. The effect of Schwarzschild objective mirror shapes on the spatial resolution is analysed. The profile of concave mirror aspherisation is considered, which provides the attainment of the diffraction-limited quality of the objective. Data are given for the quantum efficiency of the system at a wavelength of 13.5 nm. We describe the experimental test bench intended for studying the developed X-ray optical system and outline the first experimental data which illustrate its efficiency. Owing to the natural division into the 'X-ray' and 'visible' parts, the optical system under discussion permits an easy change of the magnification and the field of view without realigning the X-ray optical elements. The wavelength may be varied in a range between 3 and 40 nm by changing the multilayer mirrors.

  17. Phase-preserving beam expander for biomedical X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Martinson, Mercedes, E-mail: mercedes.m@usask.ca [University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada); Samadi, Nazanin [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); Bassey, Bassey [University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada); Gomez, Ariel [Canadian Light Source, 44 Innovation Boulevard, Saskatoon, Saskatchewan (Canada); Chapman, Dean [University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan (Canada); University of Saskatchewan, 116 Science Place, Rm 163, Saskatoon, Saskatchewan (Canada)

    2015-04-15

    Building on previous work, a phase-preserving bent Laue beam-expanding monochromator was developed with the capability of performing live animal phase contrast dynamic imaging at the Biomedical Imaging and Therapy beamline at the Canadian Light Source. The BioMedical Imaging and Therapy beamlines at the Canadian Light Source are used by many researchers to capture phase-based imaging data. These experiments have so far been limited by the small vertical beam size, requiring vertical scanning of biological samples in order to image their full vertical extent. Previous work has been carried out to develop a bent Laue beam-expanding monochromator for use at these beamlines. However, the first attempts exhibited significant distortion in the diffraction plane, increasing the beam divergence and eliminating the usefulness of the monochromator for phase-related imaging techniques. Recent work has been carried out to more carefully match the polychromatic and geometric focal lengths in a so-called ‘magic condition’ that preserves the divergence of the beam and enables full-field phase-based imaging techniques. The new experimental parameters, namely asymmetry and Bragg angles, were evaluated by analysing knife-edge and in-line phase images to determine the effect on beam divergence in both vertical and horizontal directions, using the flat Bragg double-crystal monochromator at the beamline as a baseline. The results show that by using the magic condition, the difference between the two monochromator types is less than 10% in the diffraction plane. Phase fringes visible in test images of a biological sample demonstrate that this difference is small enough to enable in-line phase imaging, despite operating at a sub-optimal energy for the wafer and asymmetry angle that was used.

  18. Exploring coherent phenomena and energy discrimination in X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, Thomas

    2011-05-04

    Conventional X-ray imaging is based on the generation of photons in materials that are selected for different applications according to their densities, dimensions, and atomic numbers. The photons produced in these targets are commonly detected by measuring the integrated amount of energy released in films or digital imaging systems. This thesis aims at extending these two paradigms. First, it is shown that the use of single-crystalline, i.e. well-ordered targets, can signif