WorldWideScience

Sample records for binding agents based

  1. Melanin-Based Coatings as Lead-Binding Agents

    Directory of Open Access Journals (Sweden)

    Karin Sono

    2012-01-01

    Full Text Available Interactions between metal ions and different forms of melanin play significant roles in melanin biochemistry. The binding properties of natural melanin and related synthetic materials can be exploited for nonbiological applications, potentially including water purification. A method for investigating metal ion-melanin interactions on solid support is described, with lead as the initial target. 2.5 cm discs of the hydrophobic polymer PVDF were coated with synthetic eumelanin from the tyrosinase-catalyzed polymerization of L-dopa, and with melanin extracted from human hair. Lead (Pb2+ binding was quantified by atomic absorption spectroscopy (flame mode, and the data was well fit by the Langmuir model. Langmuir affinities ranged from 3.4·103 to 2.2·104 M-1. At the maximum capacity observed, the synthetic eumelanin coating bound ~9% of its mass in lead. Binding of copper (Cu2+, zinc (Zn2+, and cadmium (Cd2+ to the synthetic-eumelanin-coated discs was also investigated. Under the conditions tested, the Langmuir affinities for Zn2+, Cd2+, and Cu2+ were 35%, 53%, and 77%, respectively, of the Langmuir affinity for Pb2+. The synthetic-eumelanin-coated discs have a slightly higher capacity for Cu2+ on a per mole basis than for Pb2+, and lower capacities for Cd2+ and Zn2+. The system described can be used to address biological questions and potentially be applied toward melanin-based water purification.

  2. Melanin-Based Coatings as Lead-Binding Agents

    OpenAIRE

    Karin Sono; Diane Lye; Moore, Christine A.; W. Christopher Boyd; Thomas A. Gorlin; Belitsky, Jason M.

    2012-01-01

    Interactions between metal ions and different forms of melanin play significant roles in melanin biochemistry. The binding properties of natural melanin and related synthetic materials can be exploited for nonbiological applications, potentially including water purification. A method for investigating metal ion-melanin interactions on solid support is described, with lead as the initial target. 2.5 cm discs of the hydrophobic polymer PVDF were coated with synthetic eumelanin from the tyros...

  3. Receptor binding studies of soft anticholinergic agents

    OpenAIRE

    Huang, Fenglei; Buchwald, Peter; Browne, Clinton E.; Farag, Hassan H.; Wu, Wnei-Mei; Ji, Fubao; Hochhaus, Guenther; Bodor, Nicholas

    2001-01-01

    Receptor binding studies were performed on 24 soft anticholinergic agents and 5 conventional anticholinergic agents using 4 cloned human muscarinic receptor subtypes. The measured pKi values of the soft anticholinergic agents ranged from 6.5 to 9.5, with the majority being in the range of 7.5 to 8.5. Strong correlation was observed between the pKis determined here and the pA2 values measured earlier in guinea pig ileum contraction assays. The corresponding correlation coefficients (r2) were 0...

  4. Synthesis, photochemical properties and DNA binding studies of dna cleaving agents based on chiral dipyridine dihydrodioxins salts

    Science.gov (United States)

    Shamaev, Alexei

    activated by UV-light. The mechanism of o-quinone release and intramolecular ET was studied in detail by methods of Ultrafast Transient Absortion Spectroscopy and supported by high-level quantum mechanical calculations. The binding properties of chiral intercalators based on PDHD to various DNA oligonucleotides were studied by various methods and DNA cleavage properties indicating strong binding and cleaving ability of the synthesized PDHDs. Also, a new method for synthesis of cyclohexa[e]pyrenes which possibly capable of intramolecular ET and electron transfer-oxidative stress (ET-OS) DNA cleavage was developed and partially accomplished.

  5. Agent-Based Optimization

    CERN Document Server

    Jędrzejowicz, Piotr; Kacprzyk, Janusz

    2013-01-01

    This volume presents a collection of original research works by leading specialists focusing on novel and promising approaches in which the multi-agent system paradigm is used to support, enhance or replace traditional approaches to solving difficult optimization problems. The editors have invited several well-known specialists to present their solutions, tools, and models falling under the common denominator of the agent-based optimization. The book consists of eight chapters covering examples of application of the multi-agent paradigm and respective customized tools to solve  difficult optimization problems arising in different areas such as machine learning, scheduling, transportation and, more generally, distributed and cooperative problem solving.

  6. INTERACTION OF MECHANICALLY ACTIVATED WATER WITH THE CEMENT BINDING AGENT

    Directory of Open Access Journals (Sweden)

    Gujumdzhjan Perch Pogosovich

    2012-10-01

    Full Text Available The article presents the procedure of interaction between the water and the particles of the cement binding agent, if subjected to high-speed processing inside an intensive mixing device that represents a hydrodynamic stirrer composed of a rotor and variable section turbines. The proposed method of modification (mechanical activation of the cement and water suspension makes it possible to reduce the cost of concrete due to reduction of the cement consumption rate. The research of strength-related properties of the cement stone has proven that high-speed mechanical processing of the binding agent, if mixed with the water, may improve mechanical properties of concrete by 25 to 30 %.

  7. INTERACTION OF MECHANICALLY ACTIVATED WATER WITH THE CEMENT BINDING AGENT

    OpenAIRE

    Gujumdzhjan Perch Pogosovich; Vetrenko Tat'jana Grigor'evna; Ladaev Nikolaj Mihajlovich; Zinov'eva Ekaterina Vital'evna

    2012-01-01

    The article presents the procedure of interaction between the water and the particles of the cement binding agent, if subjected to high-speed processing inside an intensive mixing device that represents a hydrodynamic stirrer composed of a rotor and variable section turbines. The proposed method of modification (mechanical activation) of the cement and water suspension makes it possible to reduce the cost of concrete due to reduction of the cement consumption rate. The research of strength-re...

  8. Microtubule-binding agents: a dynamic field of cancer therapeutics

    OpenAIRE

    Dumontet, Charles; Jordan, Mary Ann

    2010-01-01

    International audience Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an important therapeutic target in tumour cells. Agents that bind to microtubules have been part of the pharmacopoeia of anticancer therapy for decades and until the advent of targeted therapy, microtubules were the only alternative to DNA as a therapeutic target in cancer. The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agen...

  9. Metal based pharmacologically active agents: Synthesis, structural characterization, molecular modeling, CT-DNA binding studies and in vitro antimicrobial screening of iron(II) bromosalicylidene amino acid chelates

    Science.gov (United States)

    Abdel-Rahman, Laila H.; El-Khatib, Rafat M.; Nassr, Lobna A. E.; Abu-Dief, Ahmed M.; Ismael, Mohamed; Seleem, Amin Abdou

    2014-01-01

    In recent years, great interest has been focused on Fe(II) Schiff base amino acid complexes as cytotoxic and antitumor drugs. Thus a series of new iron(II) complexes based on Schiff bases amino acids ligands have been designed and synthesized from condensation of 5-bromosalicylaldehyde (bs) and α-amino acids (L-alanine (ala), L-phenylalanine (phala), L-aspartic acid (aspa), L-histidine (his) and L-arginine (arg)). The structure of the investigated iron(II) complexes was elucidated using elemental analyses, infrared, ultraviolet-visible, thermogravimetric analysis, as well as conductivity and magnetic susceptibility measurements. Moreover, the stoichiometry and the stability constants of the prepared complexes have been determined spectrophotometrically. The results suggest that 5-bromosalicylaldehyde amino acid Schiff bases (bs:aa) behave as dibasic tridentate ONO ligands and coordinate to Fe(II) in octahedral geometry according to the general formula [Fe(bs:aa)2]ṡnH2O. The conductivity values between 37 and 64 ohm-1 mol-1 cm2 in ethanol imply the presence of nonelectrolyte species. The structure of the complexes was validated using quantum mechanics calculations based on accurate DFT methods. Geometry optimization of the Fe-Schiff base amino acid complexes showed that all complexes had octahedral coordination. In addition, the interaction of these complexes with (CT-DNA) was investigated at pH = 7.2, by using UV-vis absorption, viscosity and agarose gel electrophoresis measurements. Results indicated that the investigated complexes strongly bind to calf thymus DNA via intercalative mode and showed a different DNA binding according to the sequence: bsari > bshi > bsali > bsasi > bsphali. Moreover, the prepared compounds are screened for their in vitro antibacterial and antifungal activity against three types of bacteria, Escherichia coli, Pseudomonas aeruginosa and Bacillus cereus and three types of anti fungal cultures, Penicillium purpurogenium, Aspergillus

  10. A comparative analysis on the binding characteristics of various mammalian albumins towards a multitherapeutic agent, pinostrobin

    OpenAIRE

    Feroz, Shevin R.; SUMI, Rumana A.; Sri N A Malek; Tayyab, Saad

    2014-01-01

    The interaction of pinostrobin (PS), a multitherapeutic agent with serum albumins of various mammalian species namely, goat, bovine, human, porcine, rabbit, sheep and dog was investigated using fluorescence quench titration and competitive drug displacement experiments. Analysis of the intrinsic fluorescence quenching data revealed values of the association constant, Ka in the range of 1.49 – 6.12 × 104 M−1, with 1:1 binding stoichiometry. Based on the PS–albumin binding characteristics, thes...

  11. SAM : Semantic Agent Model for SWRL rule-based agents

    OpenAIRE

    Subercaze, Julien; Maret, Pierre

    2010-01-01

    International audience SemanticWeb technologies are part of multi-agent engineering, especially regarding knowledge base support. Recent advances in the field of logic for the semantic web enable a new range of applications. Among them, programming agents based on semantic rules is a promising field. In this paper we present a semantic agent model that allows SWRL programming of agents. Our approach, based on the extended finite state machine concept, results in a three layers architecture...

  12. Studies on folate binding and a radioassay for serum and whole blood folate using goat milk as binding agent

    International Nuclear Information System (INIS)

    Preparations of cow, goat, buffalo, and human milk in addition to pig plasma were tested for folate binding properties. Of these, only pig plasma and goat milk showed sufficient binding to enable use as binding agents in a radioassay for serum and whole blood folate. The binding of folate by cow mild preparations in particular was found to be very poor. (orig.)

  13. Human brain tumor imaging with a protein-binding MR contrast agent: initial experience

    Energy Technology Data Exchange (ETDEWEB)

    Essig, Marco; Giesel, Frederik; Weber, Marc-Andre; Gerigk, Lars [German Cancer Research Center, Department of Radiology, Heidelberg (Germany); Rohrer, Martin [University of Applied Science Berlin, Berlin (Germany); Tuettenberg, Jochen [University of Heidelberg, Department of Neurosurgery, Klinikum Mannheim (Germany); Michaely, Hendrik; Voth, Matthias [University of Heidelberg, Department of Radiology, Klinikum Mannheim (Germany)

    2010-01-15

    Gadofosveset is a Gd-based protein-binding blood pool agent with increased relaxivities and blood half-life compared with conventional Gd-based contrast agents (GBCAs). No experience exists about the use of gadofosveset as an extracellular agent. In this report we present the first clinical experience with gadofosveset in enhancing intracranial tumors. Ten patients with different intracranial tumors were examined with a standard dose (0.03 mmol/kg) of gadofosveset compared with a standard dose (0.1 mmol/kg) of conventional GBCA. As a result of its significantly higher relaxivity, gadofosveset could, despite its low dose, achieve a sufficient contrast enhancement. The visual rating of the intensity of enhancement and the contrast to noise ratios were comparable to conventional agents. The detection and delineation of more complex lesions was rated equal. In one nonenhancing low grade astrocytoma an enhancing nodule became visible only 5 h after gadofosvesest injection. As shown in this initial report, contrast-enhanced intracranial tumor imaging is possible with the protein-binding blood pool agent gadofosveset. The agent gives a significant tumor contrast in early postcontrast imaging comparable with conventional agents. As a result of its unique longer lasting contrast, the use of gadofosveset might enable a new approach to imaging mild or nonenhancing tumors. (orig.)

  14. A comparative analysis on the binding characteristics of various mammalian albumins towards a multitherapeutic agent, pinostrobin.

    Science.gov (United States)

    Feroz, Shevin R; Sumi, Rumana A; Malek, Sri N A; Tayyab, Saad

    2015-01-01

    The interaction of pinostrobin (PS), a multitherapeutic agent with serum albumins of various mammalian species namely, goat, bovine, human, porcine, rabbit, sheep and dog was investigated using fluorescence quench titration and competitive drug displacement experiments. Analysis of the intrinsic fluorescence quenching data revealed values of the association constant, K(a) in the range of 1.49 - 6.12 × 10(4) M(-1), with 1:1 binding stoichiometry. Based on the PS-albumin binding characteristics, these albumins were grouped into two classes. Ligand displacement studies using warfarin as the site I marker ligand correlated well with the binding data. Albumins from goat and bovine were found to be closely similar to human albumin on the basis of PS binding characteristics. PMID:25519455

  15. Agent Assignment for Process Management: Pattern Based Agent Performance Evaluation

    Science.gov (United States)

    Jablonski, Stefan; Talib, Ramzan

    In almost all workflow management system the role concept is determined once at the introduction of workflow application and is not reevaluated to observe how successfully certain processes are performed by the authorized agents. This paper describes an approach which evaluates how agents are working successfully and feed this information back for future agent assignment to achieve maximum business benefit for the enterprise. The approach is called Pattern based Agent Performance Evaluation (PAPE) and is based on machine learning technique combined with post processing technique. We report on the result of our experiments and discuss issues and improvement of our approach.

  16. An Agent Based Classification Model

    CERN Document Server

    Gu, Feng; Greensmith, Julie

    2009-01-01

    The major function of this model is to access the UCI Wisconsin Breast Can- cer data-set[1] and classify the data items into two categories, which are normal and anomalous. This kind of classifi cation can be referred as anomaly detection, which discriminates anomalous behaviour from normal behaviour in computer systems. One popular solution for anomaly detection is Artifi cial Immune Sys- tems (AIS). AIS are adaptive systems inspired by theoretical immunology and observed immune functions, principles and models which are applied to prob- lem solving. The Dendritic Cell Algorithm (DCA)[2] is an AIS algorithm that is developed specifi cally for anomaly detection. It has been successfully applied to intrusion detection in computer security. It is believed that agent-based mod- elling is an ideal approach for implementing AIS, as intelligent agents could be the perfect representations of immune entities in AIS. This model evaluates the feasibility of re-implementing the DCA in an agent-based simulation environ- ...

  17. Agent Based Individual Traffic Guidance

    DEFF Research Database (Denmark)

    Wanscher, Jørgen

    This thesis investigates the possibilities in applying Operations Research (OR) to autonomous vehicular traffic. The explicit difference to most other research today is that we presume that an agent is present in every vehicle - hence Agent Based Individual Traffic guidance (ABIT). The next...... that the system can be divided into two separate constituents. The immediate dispersion, which is used for small areas and quick response, and the individual alleviation, which considers the longer distance decision support. Both of these require intrinsicate models and cost functions which at the...... beginning of the project were not previously considered. We define a special inseparable cost function and develop a solution complex capable of using this cost function. In relation to calibration and estimation of statistical models used for dynamic route guidance we worked with generating random number...

  18. Hepatitis C Virus Resistance to Carbohydrate-Binding Agents.

    Directory of Open Access Journals (Sweden)

    Laure Izquierdo

    Full Text Available Carbohydrate binding agents (CBAs, including natural lectins, are more and more considered as broad-spectrum antivirals. These molecules are able to directly inhibit many viruses such as Human Immunodeficiency Virus (HIV, Hepatitis C Virus (HCV, Dengue Virus, Ebola Virus or Severe Acute Respiratory Syndrome Coronavirus through binding to envelope protein N-glycans. In the case of HIV, it has been shown that CBAs select for mutant viruses with N-glycosylation site deletions which are more sensitive to neutralizing antibodies. In this study we aimed at evaluating the HCV resistance to CBAs in vitro. HCV was cultivated in the presence of increasing Galanthus nivalis agglutinin (GNA, Cyanovirin-N, Concanavalin-A or Griffithsin concentrations, during more than eight weeks. At the end of lectin exposure, the genome of the isolated strains was sequenced and several potential resistance mutations in the E1E2 envelope glycoproteins were identified. The effect of these mutations on viral fitness as well as on sensitivity to inhibition by lectins, soluble CD81 or the 3/11 neutralizing antibody was assessed. Surprisingly, none of these mutations, alone or in combination, conferred resistance to CBAs. In contrast, we observed that some mutants were more sensitive to 3/11 or CD81-LEL inhibition. Additionally, several mutations were identified in the Core and the non-structural proteins. Thus, our results suggest that in contrast to HIV, HCV resistance to CBAs is not directly conferred by mutations in the envelope protein genes but could occur through an indirect mechanism involving mutations in other viral proteins. Further investigations are needed to completely elucidate the underlying mechanisms.

  19. Agent Based Individual Traffic guidance

    DEFF Research Database (Denmark)

    Wanscher, Jørgen Bundgaard

    2004-01-01

    vehicle can be obtained through cellular phone tracking or GPS systems. This information can then be used to provide individual traffic guidance as opposed to the mass information systems of today -- dynamic roadsigns and trafficradio. The goal is to achieve better usage of road and time. The main topic......When working with traffic planning or guidance it is common practice to view the vehicles as a combined mass. >From this models are employed to specify the vehicle supply and demand for each region. As the models are complex and the calculations are equally demanding the regions and the detail of...... the road network is aggregated. As a result the calculations reveal only what the mass of vehicles are doing and not what a single vehicle is doing. This is the crucial difference to ABIT (Agent Based Individual Trafficguidance). ABIT is based on the fact that information on the destination of each...

  20. Agent-based enterprise integration

    Energy Technology Data Exchange (ETDEWEB)

    N. M. Berry; C. M. Pancerella

    1998-12-01

    The authors are developing and deploying software agents in an enterprise information architecture such that the agents manage enterprise resources and facilitate user interaction with these resources. The enterprise agents are built on top of a robust software architecture for data exchange and tool integration across heterogeneous hardware and software. The resulting distributed multi-agent system serves as a method of enhancing enterprises in the following ways: providing users with knowledge about enterprise resources and applications; accessing the dynamically changing enterprise; locating enterprise applications and services; and improving search capabilities for applications and data. Furthermore, agents can access non-agents (i.e., databases and tools) through the enterprise framework. The ultimate target of the effort is the user; they are attempting to increase user productivity in the enterprise. This paper describes their design and early implementation and discusses the planned future work.

  1. CATS-based Agents That Err

    Science.gov (United States)

    Callantine, Todd J.

    2002-01-01

    This report describes preliminary research on intelligent agents that make errors. Such agents are crucial to the development of novel agent-based techniques for assessing system safety. The agents extend an agent architecture derived from the Crew Activity Tracking System that has been used as the basis for air traffic controller agents. The report first reviews several error taxonomies. Next, it presents an overview of the air traffic controller agents, then details several mechanisms for causing the agents to err in realistic ways. The report presents a performance assessment of the error-generating agents, and identifies directions for further research. The research was supported by the System-Wide Accident Prevention element of the FAA/NASA Aviation Safety Program.

  2. An Agent-Based Distributed Manufacturing System

    Institute of Scientific and Technical Information of China (English)

    J.Li; J.Y.H.Fuh; Y.F.Zhang; A.Y.C.Nee

    2006-01-01

    Agent theories have shown their promising capability in solving distributed complex system ever since its development. In this paper, one multi-agent based distributed product design and manufacturing planning system is presented. The objective of the research is to develop a distributed collaborative design environment for supporting cooperation among the existing engineering functions. In the system, the functional agents for design, manufacturability evaluation,process planning and scheduling are efficiently integrated with a facilitator agent. This paper firstly gives an introduction to the system structure, and the definitions for each executive agent are then described and a prototype of the proposed is also included at the end part.

  3. Synthesis and crystal structure elucidation of new copper(II)-based chemotherapeutic agent coupled with 1,2-DACH and orthovanillin: Validated by in vitro DNA/HSA binding profile and pBR322 cleavage pathway.

    Science.gov (United States)

    Zaki, Mehvash; Afzal, Mohd; Ahmad, Musheer; Tabassum, Sartaj

    2016-08-01

    New copper(II)-based complex (1) was synthesized and characterized by analytical, spectroscopic and single crystal X-ray diffraction. The in vitro binding studies of complex 1 with CT DNA and HSA have been investigated by employing biophysical techniques to examine the binding propensity of 1 towards DNA and HSA. The results showed that 1 avidly binds to CT DNA via electrostatic mode along with the hydrogen bonding interaction of NH2 and CN groups of Schiff base ligand with the base pairs of DNA helix, leads to partial unwinding and destabilization of the DNA double helix. Moreover, the CD spectral studies revealed that complex 1 binds through groove binding interaction that stabilizes the right-handed B-form of DNA. Complex 1 showed an impressive photoinduced nuclease activity generating single-strand breaks in comparison with the DNA cleavage activity in presence of visible light. The mechanistic investigation revealed the efficiency of 1 to cleave DNA strands by involving the generation of reactive oxygen species. Furthermore, the time dependent DNA cleavage activity showed that there was gradual increase in the amount of NC DNA on increasing the photoexposure time. However, the interaction of 1 and HSA showed that the change of intrinsic fluorescence intensity of HSA was induced by the microenvironment of Trp residue. PMID:27289445

  4. Web-Based Computing Resource Agent Publishing

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Web-based Computing Resource Publishing is a efficient way to provide additional computing capacity for users who need more computing resources than that they themselves could afford by making use of idle computing resources in the Web.Extensibility and reliability are crucial for agent publishing. The parent-child agent framework and primary-slave agent framework were proposed respectively and discussed in detail.

  5. Comparison of crystal and solution hemoglobin binding of selected antigelling agents and allosteric modifiers

    International Nuclear Information System (INIS)

    This paper details comprehensive binding studies (solution and X-ray) of human hemoglobin A with a group of halogenated carboxylic acids that were investigated as potential antisickling agents. It is, to our knowledge, the first study to compare solution and crystal binding for a series of compounds under similar high-salt conditions used for cocrystallization. The compounds include [(3,4-dichlorobenzyl)oxy]acetic acid, [(p-bromobenzyl)oxy]acetic acid, clofibric acid, and bezafibrate. The location and stereochemistry of binding sites have been established by X-ray crystallography, while the number of binding sites and affinity constants were measured by using equilibrium dialysis. The observed crystal structures are consistent with the binding observed in solution and that the number of binding sites is independent of salt concentration, while the binding constant increases with increasing salt concentration. The studies also reveal that relatively small changes in the chemical structure of a drug molecule can result in entirely different binding sites on the protein. Moreover, the X-ray studies provide a possible explanation for the multiplicity in function exhibited by these compounds as allosteric modulators and/or antisickling agents. Finally, the studies indicate that these compounds bind differently to the R and T states of hemoglobin, and observation of special significance to the original design of these agents

  6. Comparison of crystal and solution hemoglobin binding of selected antigelling agents and allosteric modifiers

    Energy Technology Data Exchange (ETDEWEB)

    Mehanna, A.S.; Abraham, D.J. (Virginia Commonwealth Univ., Richmond (USA))

    1990-04-24

    This paper details comprehensive binding studies (solution and X-ray) of human hemoglobin A with a group of halogenated carboxylic acids that were investigated as potential antisickling agents. It is, to our knowledge, the first study to compare solution and crystal binding for a series of compounds under similar high-salt conditions used for cocrystallization. The compounds include ((3,4-dichlorobenzyl)oxy)acetic acid, ((p-bromobenzyl)oxy)acetic acid, clofibric acid, and bezafibrate. The location and stereochemistry of binding sites have been established by X-ray crystallography, while the number of binding sites and affinity constants were measured by using equilibrium dialysis. The observed crystal structures are consistent with the binding observed in solution and that the number of binding sites is independent of salt concentration, while the binding constant increases with increasing salt concentration. The studies also reveal that relatively small changes in the chemical structure of a drug molecule can result in entirely different binding sites on the protein. Moreover, the X-ray studies provide a possible explanation for the multiplicity in function exhibited by these compounds as allosteric modulators and/or antisickling agents. Finally, the studies indicate that these compounds bind differently to the R and T states of hemoglobin, and observation of special significance to the original design of these agents.

  7. Agent-Based Modeling and Mapping of Manufacturing System

    Institute of Scientific and Technical Information of China (English)

    Z; Zhang

    2002-01-01

    Considering the agent-based modeling and mapping i n manufacturing system, some system models are described in this paper, which are included: Domain Based Hierarchical Structure (DBHS), Cascading Agent Structure (CAS), Proximity Relation Structure (PRS), and Bus-based Network Structure (BNS ). In DBHS, one sort of agents, called static agents, individually acts as Domai n Agents, Resources Agents, UserInterface Agents and Gateway Agents. And the oth ers, named mobile agents, are the brokers of task and ...

  8. Assurance in Agent-Based Systems

    International Nuclear Information System (INIS)

    Our vision of the future of information systems is one that includes engineered collectives of software agents which are situated in an environment over years and which increasingly improve the performance of the overall system of which they are a part. At a minimum, the movement of agent and multi-agent technology into National Security applications, including their use in information assurance, is apparent today. The use of deliberative, autonomous agents in high-consequence/high-security applications will require a commensurate level of protection and confidence in the predictability of system-level behavior. At Sandia National Laboratories, we have defined and are addressing a research agenda that integrates the surety (safety, security, and reliability) into agent-based systems at a deep level. Surety is addressed at multiple levels: The integrity of individual agents must be protected by addressing potential failure modes and vulnerabilities to malevolent threats. Providing for the surety of the collective requires attention to communications surety issues and mechanisms for identifying and working with trusted collaborators. At the highest level, using agent-based collectives within a large-scale distributed system requires the development of principled design methods to deliver the desired emergent performance or surety characteristics. This position paper will outline the research directions underway at Sandia, will discuss relevant work being performed elsewhere, and will report progress to date toward assurance in agent-based systems

  9. Econophysics of agent-based models

    CERN Document Server

    Aoyama, Hideaki; Chakrabarti, Bikas; Chakraborti, Anirban; Ghosh, Asim

    2014-01-01

    The primary goal of this book is to present the research findings and conclusions of physicists, economists, mathematicians and financial engineers working in the field of "Econophysics" who have undertaken agent-based modelling, comparison with empirical studies and related investigations. Most standard economic models assume the existence of the representative agent, who is “perfectly rational” and applies the utility maximization principle when taking action. One reason for this is the desire to keep models mathematically tractable: no tools are available to economists for solving non-linear models of heterogeneous adaptive agents without explicit optimization. In contrast, multi-agent models, which originated from statistical physics considerations, allow us to go beyond the prototype theories of traditional economics involving the representative agent. This book is based on the Econophys-Kolkata VII Workshop, at which many such modelling efforts were presented. In the book, leading researchers in the...

  10. Ecology Based Decentralized Agent Management System

    Science.gov (United States)

    Peysakhov, Maxim D.; Cicirello, Vincent A.; Regli, William C.

    2004-01-01

    The problem of maintaining a desired number of mobile agents on a network is not trivial, especially if we want a completely decentralized solution. Decentralized control makes a system more r e bust and less susceptible to partial failures. The problem is exacerbated on wireless ad hoc networks where host mobility can result in significant changes in the network size and topology. In this paper we propose an ecology-inspired approach to the management of the number of agents. The approach associates agents with living organisms and tasks with food. Agents procreate or die based on the abundance of uncompleted tasks (food). We performed a series of experiments investigating properties of such systems and analyzed their stability under various conditions. We concluded that the ecology based metaphor can be successfully applied to the management of agent populations on wireless ad hoc networks.

  11. Agent Based Patient Scheduling Using Heuristic Algorithm

    Directory of Open Access Journals (Sweden)

    Juliet A Murali

    2010-01-01

    Full Text Available This paper describes about an agent based approach to patient scheduling using experience based learning. A heuristic algorithm is also used in the proposed framework. The evaluation on different learning techniques shows that the experience based learning (EBL gives better solution. The processing time decreases as the experience increases. The heuristic algorithm make use of EBL in calculating the processing time. The main objective of this patient scheduling system is to reduce the waiting time of patient in hospitals and to complete their treatment in minimum required time. The framework is implemented in JADE. In this approach the patients and resources are represented as patient agents (PA and resource agents (RA respectively. Even though mathematical model give optimal solution, the computational complexity increases for large size problems. Heuristic solution gives better solution for large size problems. The comparisons of the proposed framework with other scheduling rules shows that an agent based approach to patient scheduling using EBL is better.

  12. Agent-based modeling and network dynamics

    CERN Document Server

    Namatame, Akira

    2016-01-01

    The book integrates agent-based modeling and network science. It is divided into three parts, namely, foundations, primary dynamics on and of social networks, and applications. The book begins with the network origin of agent-based models, known as cellular automata, and introduce a number of classic models, such as Schelling’s segregation model and Axelrod’s spatial game. The essence of the foundation part is the network-based agent-based models in which agents follow network-based decision rules. Under the influence of the substantial progress in network science in late 1990s, these models have been extended from using lattices into using small-world networks, scale-free networks, etc. The book also shows that the modern network science mainly driven by game-theorists and sociophysicists has inspired agent-based social scientists to develop alternative formation algorithms, known as agent-based social networks. The book reviews a number of pioneering and representative models in this family. Upon the gi...

  13. Agent-oriented commonsense knowledge base

    Institute of Scientific and Technical Information of China (English)

    陆汝钤; 石纯一; 张松懋; 毛希平; 徐晋晖; 杨萍; 范路

    2000-01-01

    Common sense processing has been the key difficulty in Al community. Through analyzing various research methods on common sense, a large-scale agent-oriented commonsense knowledge base is described in this paper. We propose a new type of agent——CBS agent, specify common sense oriented semantic network descriptive language-Csnet, augment Prolog for common sense, analyze the ontology structure, and give the execution mechanism of the knowledge base.

  14. Agent-Based Data Integration Framework

    OpenAIRE

    Łukasz Faber

    2014-01-01

    Combining data from diverse, heterogeneous sources while facilitating a unified access to it is an important (albeit difficult) task. There are various possibilities of performing it. In this publication, we propose and describe an agent-based framework dedicated to acquiring and processing distributed, heterogeneous data collected from diverse sources (e.g., the Internet, external software, relational, and document databases). Using this multi-agent-based approach in the aspects of the gener...

  15. On Agent-Based Software Engineering

    OpenAIRE

    Jennings, N. R.

    2000-01-01

    Agent-based computing represents an exciting new synthesis both for Artificial Intelligence (AI) and, more generally, Computer Science. It has the potential to significantly improve the theory and the practice of modeling, designing, and implementing computer systems. Yet, to date, there has been little systematic analysis of what makes the agent-based approach such an appealing and powerful computational model. Moreover, even less effort has been devoted to discussing the inherent disadvanta...

  16. Thermal analysis of moulding sands with a polyacrylic binding agent

    Directory of Open Access Journals (Sweden)

    B. Grabowska

    2008-03-01

    Full Text Available Heating of materials causes their physical or chemical changes accompanied by thermal clfccts. Thcrmnl cfrccts of plymcrs an: rclarcd totheir structural changes. such as: melting, crystallization, polymorphous transformations, vitrification. dcgradnlion, dcstmct ion as wcll nsintramolecular or intermolecular reactions. Samples of sodium ptyacrylatc (uscd as a binding agcnr, high-silica sand (grain matrix andsamplcs of moulding sands with a potyacrylic binder aftcr hardening were tcsted derivatographically. Samplcs For thcrmal analysis wcrctaken from sham blocks aRer pcrrorming strcnglh tcsts. Invcstigations wcrc done within the tcmpcmturc rangc: 25-1000°C.Mct hds of thcrmal analysis (DTA,T G} were uscd to dacminc thc thcrmal stability of thc tcstcd snmplcs by cstablisbing rhc tcmpcsaturcand thermal effccts of transformations occurring during hcating. In addition, the invcstigations wcrc to dctcsminc changcs raking placcinside moulding sands whcn in contact with molten mctal. On the basis of differences in Ihermograms of moulding sand samptcs withpolyacrylic binding agcnt. hdcncd cithcr by Ca(Olll and C0: or by microwaves, onc cnn infcr that significant strucrural changesoccurrcd aftcr cross-linking. Thosc changes are rclatcd to intra- and intermolecular rcactions and thc way of hardcning influcnccs thccross-linking reaction - which was also confirmed by mcws of thc spectroscopic investigations (IT-IR. Rarnan, NMR.

  17. X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin

    International Nuclear Information System (INIS)

    The hemoglobin binding site of the antisickling agent 12C79 has been determined by x-ray crystallography. 12C79 is recognized as one of the first molecules to reach clinical trials that was designed, de novo, from x-ray-determined atomic coordinates of a protein. Several previous attempts to verify the proposed Hb binding sites via crystallographic studies have failed. Using revised experimental procedures, the authors obtained 12C79-deoxhemoglobin crystals grown after reaction with oxyhemoglobin and cyanoborohydride reduction to stabilize the Schiff base linkage. The difference electron-density Fourier maps show that two 12C79 molecules bind covalently to both symmetry-related N-terminal amino groups of the hemoglobin α chains. This is in contrast to the original design that proposed the binding of one drug molecule that spans the molecular dyad to interact with both N-terminal α-amino groups

  18. Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

    Science.gov (United States)

    Mahaddalkar, Tejashree; Suri, Charu; Naik, Pradeep Kumar; Lopus, Manu

    2015-08-01

    Βeta-sitosterol (β-SITO), a phytosterol present in pomegranate, peanut, corn oil, almond, and avocado, has been recognized to offer health benefits and potential clinical uses. β-SITO is orally bioavailable and, as a constituent of edible natural products, is considered to have no undesired side effects. It has also been considered as a potent anticancer agent. However, the molecular mechanism of action of β-SITO as a tubulin-binding anticancer agent and its binding site on tubulin are poorly understood. Using a combination of biochemical analyses and molecular dynamic simulation, we investigated the molecular details of the binding interactions of β-SITO with tubulin. A polymer mass assay comparing the effects of β-SITO and of taxol and vinblastine on tubulin assembly showed that this phytosterol stabilized microtubule assembly in a manner similar to taxol. An 8-anilino-1-naphthalenesulfonic acid assay confirmed the direct interaction of β-SITO with tubulin. Although β-SITO did not show direct binding to the colchicine site on tubulin, it stabilized the colchicine binding. Interestingly, no sulfhydryl groups of tubulin were involved in the binding interaction of β-SITO with tubulin. Based on the results from the biochemical assays, we computationally modeled the binding of β-SITO with tubulin. Using molecular docking followed by molecular dynamic simulations, we found that β-SITO binds tubulin at a novel site (which we call the 'SITO site') adjacent to the colchicine and noscapine sites. Our data suggest that β-SITO is a potent anticancer compound that interferes with microtubule assembly dynamics by binding to a novel site on tubulin. PMID:25912799

  19. Intelligent agent based control of TL-1

    International Nuclear Information System (INIS)

    The Agent based control of complex systems is becoming popular due to its ability to identify the critical situation and its ability to dynamically search for the best available solution to the problem with constrained optimization of the inputs. In this paper we are presenting the architecture of intelligent agent for automatic control of power supplies of TL-1 (Transfer Line 1) to maximise the injection process against the changes in the input beam obtained from Microtron. The paper discusses the results obtained by applying this agent architecture to the accelerator model comprises of Microtron output, TL-1 and booster. (author)

  20. Spatial interactions in agent-based modeling

    CERN Document Server

    Ausloos, Marcel; Merlone, Ugo

    2014-01-01

    Agent Based Modeling (ABM) has become a widespread approach to model complex interactions. In this chapter after briefly summarizing some features of ABM the different approaches in modeling spatial interactions are discussed. It is stressed that agents can interact either indirectly through a shared environment and/or directly with each other. In such an approach, higher-order variables such as commodity prices, population dynamics or even institutions, are not exogenously specified but instead are seen as the results of interactions. It is highlighted in the chapter that the understanding of patterns emerging from such spatial interaction between agents is a key problem as much as their description through analytical or simulation means. The chapter reviews different approaches for modeling agents' behavior, taking into account either explicit spatial (lattice based) structures or networks. Some emphasis is placed on recent ABM as applied to the description of the dynamics of the geographical distribution o...

  1. Agent-based simulation of animal behaviour

    OpenAIRE

    Jonker, C.M.; Treur, J.

    1998-01-01

    In this paper it is shown how animal behaviour can be simulated in an agent-based manner. Different models are shown for different types of behaviour, varying from purely reactive behaviour to pro-active, social and adaptive behaviour. The compositional development method for multi-agent systems DESIRE and its software environment supports the conceptual and detailed design, and execution of these models. Experiments reported in the literature on animal behaviour have been simulated for a num...

  2. Identification of a Common Binding Mode for Imaging Agents to Amyloid Fibrils from Molecular Dynamics Simulations

    DEFF Research Database (Denmark)

    Skeby, Katrine Kirkeby; Sørensen, Jesper; Schiøtt, Birgit

    2013-01-01

    amyloid fibrils and the disease pathology. Alzheimer’s disease is very difficult to diagnose, and much research is being performed to develop noninvasive diagnostic methods, such as imaging with small-molecule agents. The interactions between amyloid fibrils and imaging agents are challenging to examine...... experimentally due to the insoluble nature of amyloid fibrils. This study uses molecular dynamics simulations to investigate the interactions between 13 aromatic amyloid imaging agents, entailing 4 different organic scaffolds, and a model of an amyloid fibril. Clustering analysis combined with free energy...... binding modes for imaging agents is proposed to originate from subtle differences in amino acid composition of the surface grooves on an amyloid fibril, resulting in fine tuning of the binding affinities for a specific amyloid fibril....

  3. Agent Based Image Segmentation Method : A Review

    OpenAIRE

    Pooja Mishra; Navita Srivastava; Shukla, K. K.; Achintya Singlal

    2011-01-01

    Image segmentation is an important research area in computer vision and many segmentation methods have been proposed. This paper attempts to provide a brief overview of elemental segmentation techniques based on boundary or regional approaches. It focuses mainly on the agent based image segmentation techniques

  4. Behavior-based dual dynamic agent architecture

    Institute of Scientific and Technical Information of China (English)

    仵博; 吴敏; 曹卫华

    2003-01-01

    The objective of the architecture is to make agent promptly and adaptively accomplish tasks in the real-time and dynamic environment. The architecture is composed of elementary level behavior layer and high level be-havior layer. In the elementary level behavior layer, the reactive architecture is introduced to make agent promptlyreact to events; in the high level behavior layer, the deliberation architecture is used to enhance the intelligence ofthe agent. A confidence degree concept is proposed to combine the two layers of the architecture. An agent decisionmaking process is also presented, which is based on the architecture. The results of experiment in RoboSoccer simu-lation team show that the proposed architecture and the decision process are successful.

  5. Agent-based Modeling and Mapping of Manufacturing System

    Institute of Scientific and Technical Information of China (English)

    Z; Zhang

    2002-01-01

    Considering the gent-based modeling and mapping in m anufacturing system, in this paper, some system models are described, which are including: Domain Based Hierarchical Structure (DBHS), Cascading Agent Struc ture (CAS), Proximity Relation structure (PRS), and Bus-based network structure (BNS). In DBHS, one sort of agent individually delegates Domain Agents, Res ources Agents, UserInterface Agents and Gateway Agents and the other one is a br oker of tasks and process flow. Static agents representing...

  6. Understanding the in vivo uptake kinetics of a phosphatidylethanolamine-binding agent 99mTc-Duramycin

    International Nuclear Information System (INIS)

    Introduction: 99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between 99mTc-Duramycin and the target tissue. Methods: High level of accessible PE is induced in cardiac tissues by myocardial ischemia (30 min) and reperfusion (120 min) in Sprague–Dawley rats. Target binding and biodistribution of 99mTc-duramycin were captured using SPECT/CT. To quantify the binding kinetics, the presence of radioactivity in ischemic versus normal cardiac tissues was measured by gamma counting at 3, 10, 20, 60 and 180 min after injection. A partially inactivated form of 99mTc-Duramycin was analyzed in the same fashion. A compartment model was developed to quantify the uptake kinetics of 99mTc-Duramycin in normal and ischemic myocardial tissue. Results: 99mTc-duramycin binds avidly to the damaged tissue with a high target-to-background radio. Compartment modeling shows that accessibility of binding sites in myocardial tissue to 99mTc-Duramycin is not a limiting factor and the rate constant of target binding in the target tissue is at 2.2 ml/nmol/min/g. The number of available binding sites for 99mTc-Duramycin in ischemic myocardium was estimated at 0.14 nmol/g. Covalent modification of D15 resulted in a 9-fold reduction in binding affinity. Conclusion: 99mTc-Duramycin accumulates avidly in target tissues in a PE-dependent fashion. Model results reflect an efficient uptake mechanism, consistent with the low molecular weight of the radiopharmaceutical and the relatively high density of available binding sites. These data help better define the imaging utilities of 99mTc-Duramycin as a novel PE-binding agent.

  7. Agent Based Modelling for Social Simulation

    NARCIS (Netherlands)

    Smit, S.K.; Ubink, E.M.; Vecht, B. van der; Langley, D.J.

    2013-01-01

    This document is the result of an exploratory project looking into the status of, and opportunities for Agent Based Modelling (ABM) at TNO. The project focussed on ABM applications containing social interactions and human factors, which we termed ABM for social simulation (ABM4SS). During the course

  8. Gd-HOPO Based High Relaxivity MRI Contrast Agents

    Energy Technology Data Exchange (ETDEWEB)

    Datta, Ankona; Raymond, Kenneth

    2008-11-06

    Tris-bidentate HOPO-based ligands developed in our laboratory were designed to complement the coordination preferences of Gd{sup 3+}, especially its oxophilicity. The HOPO ligands provide a hexadentate coordination environment for Gd{sup 3+} in which all he donor atoms are oxygen. Because Gd{sup 3+} favors eight or nine coordination, this design provides two to three open sites for inner-sphere water molecules. These water molecules rapidly exchange with bulk solution, hence affecting the relaxation rates of bulk water olecules. The parameters affecting the efficiency of these contrast agents have been tuned to improve contrast while still maintaining a high thermodynamic stability for Gd{sup 3+} binding. The Gd- HOPO-based contrast agents surpass current commercially available agents ecause of a higher number of inner-sphere water molecules, rapid exchange of inner-sphere water molecules via an associative mechanism, and a long electronic relaxation time. The contrast enhancement provided by these agents is at least twice that of commercial contrast gents, which are based on polyaminocarboxylate ligands.

  9. FIPA agent based network distributed control system

    International Nuclear Information System (INIS)

    A control system with the capabilities to combine heterogeneous control systems or processes into a uniform homogeneous environment is discussed. This dynamically extensible system is an example of the software system at the agent level of abstraction. This level of abstraction considers agents as atomic entities that communicate to implement the functionality of the control system. Agents' engineering aspects are addressed by adopting the domain independent software standard, formulated by FIPA. Jade core Java classes are used as a FIPA specification implementation. A special, lightweight, XML RDFS based, control oriented, ontology markup language is developed to standardize the description of the arbitrary control system data processor. Control processes, described in this language, are integrated into the global system at runtime, without actual programming. Fault tolerance and recovery issues are also addressed

  10. FIPA agent based network distributed control system

    Energy Technology Data Exchange (ETDEWEB)

    D. Abbott; V. Gyurjyan; G. Heyes; E. Jastrzembski; C. Timmer; E. Wolin

    2003-03-01

    A control system with the capabilities to combine heterogeneous control systems or processes into a uniform homogeneous environment is discussed. This dynamically extensible system is an example of the software system at the agent level of abstraction. This level of abstraction considers agents as atomic entities that communicate to implement the functionality of the control system. Agents' engineering aspects are addressed by adopting the domain independent software standard, formulated by FIPA. Jade core Java classes are used as a FIPA specification implementation. A special, lightweight, XML RDFS based, control oriented, ontology markup language is developed to standardize the description of the arbitrary control system data processor. Control processes, described in this language, are integrated into the global system at runtime, without actual programming. Fault tolerance and recovery issues are also addressed.

  11. Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase Iα: in vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines.

    Science.gov (United States)

    Tabassum, Sartaj; Zaki, Mehvash; Afzal, Mohd; Arjmand, Farukh

    2014-03-01

    New metal-based anticancer chemotherapeutic drug candidates [Cu(phen)L](NO₃)₂ (1) and [Zn(phen)L](NO₃)₂ (2) were synthesized from ligand L (derived from pharmacophore scaffold barbituric acid and pyrazole). In vitro DNA binding studies of the L, 1 and 2 were carried out by various biophysical techniques revealing electrostatic mode. Complex 1 cleaves pBR322 DNA via oxidative pathway and recognizes major groove of DNA double helix. The molecular docking study was carried out to ascertain the mode of action towards the molecular target DNA and enzymes. The complex 1 exhibited remarkably good anticancer activity on a panel of human cancer cell lines (GI₅₀ values < 10 μg/ml), and to elucidate the mechanism of cancer inhibition, Topo-I enzymatic activity was carried out. PMID:24508781

  12. Interaction Protocols in Multi-Agent Systems based on Agent Petri Nets Model

    Directory of Open Access Journals (Sweden)

    Kamel Barkaoui

    2013-08-01

    Full Text Available This paper deals with the modeling of interaction between agents in Multi Agents System (MAS based on Agent Petri Nets (APN. Our models are created based on communicating agents. Indeed, an agent initiating a conversation with other can specify the interaction protocol wishes to follow. The combination of APN and FIPA Protocols schemes leads to a set of deployment formal rules for points where model interaction can be successfully implemented. We introduce some models FIPA standard protocols.

  13. Agent-Based Mobile Event Notification System

    Directory of Open Access Journals (Sweden)

    Rania Fahim El-Gazzar

    2010-10-01

    Full Text Available In recent years, the noticeable move towards using mobile devices (mobile phones and PDAs and wireless technologies have made information available in the context of "anytime, anywhere using any mobile device" experience. Delivering information to mobile devices needs some sort of communication means such as Push, Pull, or mixed (Push and Pull technologies to deliver any chunk of information (events, ads, advisory tips, learning materials, etc.. Events are the most important pieces of information that should be delivered timely wherever the user is. Agent-based technology offers autonomous, flexible, adaptable, and reliable way of delivering events to any device, anywhere, and on time. Publish/subscribe communication model is the basic infrastructure for event-based communication. In this paper, we define the need to mobilize the event notification process in educational environment and the possible categories of event notifications that students can receive from their educational institution. This paper also proposes a framework for agent-based mobile event notification system. The proposed framework is derived from the concept of push–based publish/subscribe communication model but taking advantage from software agents to serve in the mobile environment. Finally, the paper provides a detailed analysis for the proposed system.

  14. Agent Based Modeling in Public Administration

    Directory of Open Access Journals (Sweden)

    Osman SEYHAN

    2013-06-01

    Full Text Available This study aims to explore the role of agent based modeling (ABM as a simulation method in analyzing and formulating the policy making processes and modern public management that is under the pressure of information age and socio-politic demands of open societies. ABM is a simulative research method to understand complex adaptive systems (cas from the perspective of its constituent entities. In this study, by employing agent based computing and Netlogo language, twocase studies about organizational design and organizational riskanalyses have been examined. Results revealed that ABM is anefficient platform determining the optimum results from various scenarios in order to understand structures and processes about policy making in both organizational design and risk management. In the future, more researches are needed about understanding role of ABM on understanding and making decision on future of cas especially in conjunction with developments in computer technologies.

  15. Agent-Based Data Integration Framework

    Directory of Open Access Journals (Sweden)

    Łukasz Faber

    2014-01-01

    Full Text Available Combining data from diverse, heterogeneous sources while facilitating a unified access to it is an important (albeit difficult task. There are various possibilities of performing it. In this publication, we propose and describe an agent-based framework dedicated to acquiring and processing distributed, heterogeneous data collected from diverse sources (e.g., the Internet, external software, relational, and document databases. Using this multi-agent-based approach in the aspects of the general architecture (the organization and management of the framework, we create a proof-of-concept implementation. The approach is presented using a sample scenario in which the system is used to search for personal and professional profiles of scientists.

  16. Intelligent Agent-Based System for Digital Library Information Retrieval

    Institute of Scientific and Technical Information of China (English)

    师雪霖; 牛振东; 宋瀚涛; 宋丽哲

    2003-01-01

    A new information search model is reported and the design and implementation of a system based on intelligent agent is presented. The system is an assistant information retrieval system which helps users to search what they need. The system consists of four main components: interface agent, information retrieval agent, broker agent and learning agent. They collaborate to implement system functions. The agents apply learning mechanisms based on an improved ID3 algorithm.

  17. Agent Based Intelligence in a Tetrahedral Rover

    Science.gov (United States)

    Phelps, Peter; Truszkowski, Walt

    2007-01-01

    A tetrahedron is a 4-node 6-strut pyramid structure which is being used by the NASA - Goddard Space Flight Center as the basic building block for a new approach to robotic motion. The struts are extendable; it is by the sequence of activities: strut-extension, changing the center of gravity and falling that the tetrahedron "moves". Currently, strut-extension is handled by human remote control. There is an effort underway to make the movement of the tetrahedron autonomous, driven by an attempt to achieve a goal. The approach being taken is to associate an intelligent agent with each node. Thus, the autonomous tetrahedron is realized as a constrained multi-agent system, where the constraints arise from the fact that between any two agents there is an extendible strut. The hypothesis of this work is that, by proper composition of such automated tetrahedra, robotic structures of various levels of complexity can be developed which will support more complex dynamic motions. This is the basis of the new approach to robotic motion which is under investigation. A Java-based simulator for the single tetrahedron, realized as a constrained multi-agent system, has been developed and evaluated. This paper reports on this project and presents a discussion of the structure and dynamics of the simulator.

  18. Agent Based Process Management Environment – Mercury

    OpenAIRE

    Jeong Ah Kim; Seung Young Choi; Rhan Jung

    2007-01-01

    In this article, agent based process management model is proposed, which is for the process management of knowledge worker and service workers in order to establish the basis for the new knowledge management system. In this article, we applied several methods from 6-Sigma and personal software process for personal process definition, process execution and process measurement. This study attempts to improve the process execution accuracy through process visualisation and standardisation and to...

  19. Enhancing the Combat ID Agent Based Model

    OpenAIRE

    Spaans, M.; Petiet, P.J.; Dean, D; Jackson, J.; Bradley, W.; Shan, L. Y.; Ka-Yoon, W.; Yongwei, D.W.; Kai, C.W.

    2007-01-01

    During previous Project Albert and International data Farming Workshops (IDFW) and during discussions between Dstl and TNO, the suitability and feasibility of Agent Based Models (ABMs) to support research on Combat Identification (Combat ID) was examined. The objective of this research is to: Investigate the effect of (a large number of) different variations in Situational Awareness, Situation Awareness (SA), Target Identification (Target ID), Human Factors, and Tactics, Techniques, and Proce...

  20. Agent-Based Modeling in Systems Pharmacology.

    Science.gov (United States)

    Cosgrove, J; Butler, J; Alden, K; Read, M; Kumar, V; Cucurull-Sanchez, L; Timmis, J; Coles, M

    2015-11-01

    Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling. PMID:26783498

  1. Agent-based Models of Financial Markets

    OpenAIRE

    Samanidou, E.; E. Zschischang; Stauffer, D.; Lux, T.

    2007-01-01

    This review deals with several microscopic (``agent-based'') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our sel...

  2. Surveillance software based on agents system

    OpenAIRE

    José M. Molina

    2008-01-01

    The Applied Artificial Intelligence group has developed a surveillance system based on the agents theory and multiagents system in the Distributed Artificial Intelligence. The system allows that each data acquisition source could operate independently, but coordinated by a central host. The technology improves the surveillance process, reducing the human attention and introducing automatic alarms. They are looking for technical cooperation of partners interested in the technology.

  3. CATS-based Air Traffic Controller Agents

    Science.gov (United States)

    Callantine, Todd J.

    2002-01-01

    This report describes intelligent agents that function as air traffic controllers. Each agent controls traffic in a single sector in real time; agents controlling traffic in adjoining sectors can coordinate to manage an arrival flow across a given meter fix. The purpose of this research is threefold. First, it seeks to study the design of agents for controlling complex systems. In particular, it investigates agent planning and reactive control functionality in a dynamic environment in which a variety perceptual and decision making skills play a central role. It examines how heuristic rules can be applied to model planning and decision making skills, rather than attempting to apply optimization methods. Thus, the research attempts to develop intelligent agents that provide an approximation of human air traffic controller behavior that, while not based on an explicit cognitive model, does produce task performance consistent with the way human air traffic controllers operate. Second, this research sought to extend previous research on using the Crew Activity Tracking System (CATS) as the basis for intelligent agents. The agents use a high-level model of air traffic controller activities to structure the control task. To execute an activity in the CATS model, according to the current task context, the agents reference a 'skill library' and 'control rules' that in turn execute the pattern recognition, planning, and decision-making required to perform the activity. Applying the skills enables the agents to modify their representation of the current control situation (i.e., the 'flick' or 'picture'). The updated representation supports the next activity in a cycle of action that, taken as a whole, simulates air traffic controller behavior. A third, practical motivation for this research is to use intelligent agents to support evaluation of new air traffic control (ATC) methods to support new Air Traffic Management (ATM) concepts. Current approaches that use large, human

  4. Basalt fiber insulating material with a mineral binding agent for industrial use

    Science.gov (United States)

    Drozdyuk, T.; Aizenshtadt, A.; Tutygin, A.; Frolova, M.

    2016-04-01

    The paper considers a possibility of using mining industry waste as a binding agent for heat insulating material on the basis of basalt fiber. The main objective of the research is to produce a heat-insulating material to be applied in machine building in high-temperature environments. After synthetic binder having been replaced by a mineral one, an environmentally sound thermal insulating material having desirable heat-protecting ability and not failing when exposed to high temperatures was obtained.

  5. The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II.

    Science.gov (United States)

    Bruno, Claudio; Cavalluzzi, Maria Maddalena; Rusciano, Maria Rosaria; Lovece, Angelo; Carrieri, Antonio; Pracella, Riccardo; Giannuzzi, Giulia; Polimeno, Lorenzo; Viale, Maurizio; Illario, Maddalena; Franchini, Carlo; Lentini, Giovanni

    2016-06-30

    An affinity capillary electrophoresis (ACE) method to estimate apparent dissociation constants between bovine brain calmodulin (CaM) and non-peptidic ligands was developed. The method was validated reproducing the dissociation constants of a number of well-known CaM ligands. In particular, the potent antagonist 125-C9 was ad hoc synthesized through an improved synthetic procedure. The ACE method was successfully applied to verify CaM affinity for lubeluzole, a well-known neuroprotective agent recently proved useful to potentiate the activity of anti-cancer drugs. Lubeluzole was slightly less potent than 125-C9 (Kd = 2.9 ± 0.7 and 0.47 ± 0.06 μM, respectively) and displayed Ca(2+)/calmodulin-dependent kinase II (CaMKII) inhibition (IC50 = 40 ± 1 μM). Possible binding modes of lubeluzole to CaM were explored by docking studies based on the X-ray crystal structures of several trifluoperazine-CaM complexes. An estimated dissociation constant in good agreement with the experimental one was found and the main aminoacidic residues and interactions contributing to complex formation were highlighted. The possibility that interference with Ca(2+) pathways may contribute to the previously observed chemosensitizing effects of lubeluzole on human ovarian adenocarcinoma and lung carcinoma cells are discussed. PMID:27043269

  6. Multiscale agent-based consumer market modeling.

    Energy Technology Data Exchange (ETDEWEB)

    North, M. J.; Macal, C. M.; St. Aubin, J.; Thimmapuram, P.; Bragen, M.; Hahn, J.; Karr, J.; Brigham, N.; Lacy, M. E.; Hampton, D.; Decision and Information Sciences; Procter & Gamble Co.

    2010-05-01

    Consumer markets have been studied in great depth, and many techniques have been used to represent them. These have included regression-based models, logit models, and theoretical market-level models, such as the NBD-Dirichlet approach. Although many important contributions and insights have resulted from studies that relied on these models, there is still a need for a model that could more holistically represent the interdependencies of the decisions made by consumers, retailers, and manufacturers. When the need is for a model that could be used repeatedly over time to support decisions in an industrial setting, it is particularly critical. Although some existing methods can, in principle, represent such complex interdependencies, their capabilities might be outstripped if they had to be used for industrial applications, because of the details this type of modeling requires. However, a complementary method - agent-based modeling - shows promise for addressing these issues. Agent-based models use business-driven rules for individuals (e.g., individual consumer rules for buying items, individual retailer rules for stocking items, or individual firm rules for advertizing items) to determine holistic, system-level outcomes (e.g., to determine if brand X's market share is increasing). We applied agent-based modeling to develop a multi-scale consumer market model. We then conducted calibration, verification, and validation tests of this model. The model was successfully applied by Procter & Gamble to several challenging business problems. In these situations, it directly influenced managerial decision making and produced substantial cost savings.

  7. Agent fabrication and its implementation for agent-based electronic commerce

    OpenAIRE

    Guan, Su; Zhu, F.

    2002-01-01

    In the last decade, agent-based e-commerce has emerged as a potential role for the next generation of e-commerce. How to create agents for e-commerce applications has become a serious consideration in this field. This paper proposes a new scheme named agent fabrication and elaborates its implementation in multi-agent systems based on the SAFER (Secure Agent Fabrication, Evolution & Roaming) architecture. First, a conceptual structure is proposed for software agents carrying out e-commerce act...

  8. Implementation of Agent Based Dynamic Distributed Service

    Directory of Open Access Journals (Sweden)

    A.Damodaram

    2010-01-01

    Full Text Available The concept of distributed computing implies a network / internet-work of independent nodes which are logically configured in such a manner as to be seen as one machine by an application. They have been implemented in many varying forms and configurations, for the optimal processing of data. Agents and multi-agent systems are useful in modeling complex distributed processes. They focus on support for (the development of large-scale, secure, and heterogeneous distributed systems. They are expected to abstract both hardware and software vis-à-vis distributed systems. For optimizing the use of the tremendous increase in processing power, bandwidth, and memory that technology is placing in the hands of the designer, a Dynamically Distributed Service (to be positioned as a service to a network / internet-work is proposed. The service will conceptually migrate an application on to different nodes. In this paper, we present the design and implementation of an inter-mobility (migration mechanism for agents. This migration is based on FIPA ACL messages. We also evaluate the performance of this implementation.

  9. Agent-based modeling and simulation

    CERN Document Server

    Taylor, Simon

    2014-01-01

    Operational Research (OR) deals with the use of advanced analytical methods to support better decision-making. It is multidisciplinary with strong links to management science, decision science, computer science and many application areas such as engineering, manufacturing, commerce and healthcare. In the study of emergent behaviour in complex adaptive systems, Agent-based Modelling & Simulation (ABMS) is being used in many different domains such as healthcare, energy, evacuation, commerce, manufacturing and defense. This collection of articles presents a convenient introduction to ABMS with pa

  10. An Agent-Based Monetary Production Simulation Model

    DEFF Research Database (Denmark)

    Bruun, Charlotte

    2006-01-01

    An Agent-Based Simulation Model Programmed in Objective Borland Pascal. Program and source code is downloadable......An Agent-Based Simulation Model Programmed in Objective Borland Pascal. Program and source code is downloadable...

  11. Security Framework for Agent-Based Cloud Computing

    Directory of Open Access Journals (Sweden)

    K Venkateshwaran

    2015-06-01

    Full Text Available Agent can play a key role in bringing suitable cloud services to the customer based on their requirements. In agent based cloud computing, agent does negotiation, coordination, cooperation and collaboration on behalf of the customer to make the decisions in efficient manner. However the agent based cloud computing have some security issues like (a. addition of malicious agent in the cloud environment which could demolish the process by attacking other agents, (b. denial of service by creating flooding attacks on other involved agents. (c. Some of the exceptions in the agent interaction protocol such as Not-Understood and Cancel_Meta protocol can be misused and may lead to terminating the connection of all the other agents participating in the negotiating services. Also, this paper proposes algorithms to solve these issues to ensure that there will be no intervention of any malicious activities during the agent interaction.

  12. Competitive receptor binding radioassay for β-1 and β-2 adrenergic agents

    International Nuclear Information System (INIS)

    A rapid and sensitive competitive receptor bonding assay for β-1 and β-2 adrenergic binding for adrenergic agents has been developed. The steps that are critical for the success of the assay are given in detail so that the assay can be set up in any routine laboratory with relative ease. The rationale behind the use of specific reagents is discussed. The assay requires microgram quantities of test compound, a radiolabeled specific β adrenergic antagonist [3H]dihydroalprenolol (DHA), and turkey erythrocyte β-1 and rat erythrocyte β-2 receptor membranes. Serial dilutions of sample are incubated with appropriate receptor membranes and DHA for 1 hr at room temperature. After equilibrium is attained, the bound radioligand is separated by rapid filtration under vacuum through Whatman GF/B filters. The amount of bound DHA trapped on the filter is inversely proportional to the degree of β-1 and β-2 adrenergic binding of the sample. Separation of bound from free radioligand by filtration permits rapid determination of a large number of samples. This assay quantitates and differentiates β-1 and β-2 adrenergic binding of synthetic adrenergic agents

  13. Agent Based Modeling as an Educational Tool

    Science.gov (United States)

    Fuller, J. H.; Johnson, R.; Castillo, V.

    2012-12-01

    Motivation is a key element in high school education. One way to improve motivation and provide content, while helping address critical thinking and problem solving skills, is to have students build and study agent based models in the classroom. This activity visually connects concepts with their applied mathematical representation. "Engaging students in constructing models may provide a bridge between frequently disconnected conceptual and mathematical forms of knowledge." (Levy and Wilensky, 2011) We wanted to discover the feasibility of implementing a model based curriculum in the classroom given current and anticipated core and content standards.; Simulation using California GIS data ; Simulation of high school student lunch popularity using aerial photograph on top of terrain value map.

  14. Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

    Directory of Open Access Journals (Sweden)

    Al-Balas QA

    2016-08-01

    Full Text Available Qosay A Al-Balas,1 Mohammad A Hassan,1 Nizar A Al-Shar’i,1 Nizar M Mhaidat,2 Ammar M Almaaytah,3 Fatima M Al-Mahasneh,1 Israa H Isawi1 1Department of Medicinal Chemistry and Pharmacognosy, 2Department of Clinical Pharmacy, 3Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan Background: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased cellular levels of these toxic metabolites. The increased activity of the detoxification system in cancerous cells makes this pathway a viable target for developing novel anticancer agents. In this study, we examined the potential utility of non-glutathione-based inhibitors of the Glo-I enzyme as novel anticancer drugs.Methods: Computer-aided drug design techniques, such as customized pharmacophoric features, virtual screening, and flexible docking, were used to achieve the project goals. Retrieved hits were extensively filtered and subsequently docked into the active site of the enzyme. The biological activities of retrieved hits were assessed using an in vitro assay against Glo-I.Results: Since Glo-I is a zinc metalloenzyme, a customized Zn-binding pharmacophoric feature was used to search for selective inhibitors via virtual screening of a small-molecule database. Seven hits were selected, purchased, and biologically evaluated. Three of the seven hits inhibited Glo-I activity, the most effective of which exerted 76.4% inhibition at a concentration of 25 µM.Conclusion: We successfully identified a potential Glo-I inhibitor that can serve as a lead compound for further optimization. Moreover, our in silico and experimental results were highly correlated. Hence, the docking protocol adopted in this study may

  15. Effects of Drying Condition and Binding Agent on the Quality Characteristics of Ground Dried-Pork Meat Products

    OpenAIRE

    Choi, Yun-Sang; Ku, Su-Kyung; Park, Jong-Dae; Kim, Hee-Ju; Jang, Aera; Kim, Young-Boong

    2015-01-01

    The purpose of this study was to investigate the influence of processing conditions (temperature and time) and binding agent types (glutinous rice flour, potato starch, bean flour, and acorn flour) on the physicochemical and sensory characteristics of ground dried-pork meat product. For this purpose, ground dried-pork meat product was produced by adding several binding agents at different drying temperatures and times. The drying time affected moisture content and water activity in all drying...

  16. Agent Communication Channel Based on BACnet

    Institute of Scientific and Technical Information of China (English)

    Jiang Wen-bin; Zhou Man-li

    2004-01-01

    We analyze the common shortcoming in the existing agent MTPs (message transport protocols). With employing the File object and related service AtomicWriteFile of BACnet (a data communication protocol building automation and control networks), a new method of agent message transport is proposed and implemented. Every agent platform (AP) has one specified File object and agents in another AP can communicate with agents in the AP by using AtomicWriteFile service. Agent messages can be in a variety of formats. In implementation, BACnet/IP and Ethernet are applied as the BACnet data link layers respectively. The experiment results show that the BACnet can provide perfect support for agent communication like other conventional protocols such as hypertext transfer protocol(HTTP), remote method invocation (RMI) etc. and has broken through the restriction of TCP/IP. By this approach, the agent technology is introduced into the building automation control network system.

  17. Agent-based models of financial markets

    International Nuclear Information System (INIS)

    This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we discuss the Cont

  18. Agent-based models of financial markets

    Science.gov (United States)

    Samanidou, E.; Zschischang, E.; Stauffer, D.; Lux, T.

    2007-03-01

    This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we discuss the Cont

  19. Agent-based models of financial markets

    Energy Technology Data Exchange (ETDEWEB)

    Samanidou, E [Department of Economics, University of Kiel, Olshausenstrasse 40, D-24118 Kiel (Germany); Zschischang, E [HSH Nord Bank, Portfolio Mngmt. and Inv., Martensdamm 6, D-24103 Kiel (Germany); Stauffer, D [Institute for Theoretical Physics, Cologne University, D-50923 Koeln (Germany); Lux, T [Department of Economics, University of Kiel, Olshausenstrasse 40, D-24118 Kiel (Germany)

    2007-03-15

    This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we

  20. Agent Based Model of Livestock Movements

    Science.gov (United States)

    Miron, D. J.; Emelyanova, I. V.; Donald, G. E.; Garner, G. M.

    The modelling of livestock movements within Australia is of national importance for the purposes of the management and control of exotic disease spread, infrastructure development and the economic forecasting of livestock markets. In this paper an agent based model for the forecasting of livestock movements is presented. This models livestock movements from farm to farm through a saleyard. The decision of farmers to sell or buy cattle is often complex and involves many factors such as climate forecast, commodity prices, the type of farm enterprise, the number of animals available and associated off-shore effects. In this model the farm agent's intelligence is implemented using a fuzzy decision tree that utilises two of these factors. These two factors are the livestock price fetched at the last sale and the number of stock on the farm. On each iteration of the model farms choose either to buy, sell or abstain from the market thus creating an artificial supply and demand. The buyers and sellers then congregate at the saleyard where livestock are auctioned using a second price sealed bid. The price time series output by the model exhibits properties similar to those found in real livestock markets.

  1. Population Control for Multi-agent Based Topical Crawlers

    OpenAIRE

    Mouton, Alban; Marteau, Pierre-François

    2008-01-01

    International audience The use of multi-agent topical Web crawlers based on the endogenous fitness model raises the problem of controling the population of agents. We tackle this question through an energy based model to balance the reproduction/life expectency of agents. Our goal is to simplify the tuning of parameters and to optimize the use of ressources available for the crawling. We introduce an energy based model designed to control the number of agents according to the precision of ...

  2. Construct validity of agent-based simulation of normative behaviour

    OpenAIRE

    Xenitidou, M; Elsenbroich, C

    2011-01-01

    In this paper we assess the construct validity and theoretical emdeddedness of agent-based models of normative behaviour drawing on experimental social psychology. We contend that social psychology and agent-based modelling share the focus of ‘observing’ the processes and outcomes of the interaction of individual agents. The paper focuses on two from a taxonomy of agent-based models of normative behaviour. This enables the identification of the assumptions the models are built on and in turn,...

  3. Knowledge-based fragment binding prediction.

    Science.gov (United States)

    Tang, Grace W; Altman, Russ B

    2014-04-01

    Target-based drug discovery must assess many drug-like compounds for potential activity. Focusing on low-molecular-weight compounds (fragments) can dramatically reduce the chemical search space. However, approaches for determining protein-fragment interactions have limitations. Experimental assays are time-consuming, expensive, and not always applicable. At the same time, computational approaches using physics-based methods have limited accuracy. With increasing high-resolution structural data for protein-ligand complexes, there is now an opportunity for data-driven approaches to fragment binding prediction. We present FragFEATURE, a machine learning approach to predict small molecule fragments preferred by a target protein structure. We first create a knowledge base of protein structural environments annotated with the small molecule substructures they bind. These substructures have low-molecular weight and serve as a proxy for fragments. FragFEATURE then compares the structural environments within a target protein to those in the knowledge base to retrieve statistically preferred fragments. It merges information across diverse ligands with shared substructures to generate predictions. Our results demonstrate FragFEATURE's ability to rediscover fragments corresponding to the ligand bound with 74% precision and 82% recall on average. For many protein targets, it identifies high scoring fragments that are substructures of known inhibitors. FragFEATURE thus predicts fragments that can serve as inputs to fragment-based drug design or serve as refinement criteria for creating target-specific compound libraries for experimental or computational screening. PMID:24762971

  4. From Agents to Continuous Change via Aesthetics: Learning Mechanics with Visual Agent-Based Computational Modeling

    Science.gov (United States)

    Sengupta, Pratim; Farris, Amy Voss; Wright, Mason

    2012-01-01

    Novice learners find motion as a continuous process of change challenging to understand. In this paper, we present a pedagogical approach based on agent-based, visual programming to address this issue. Integrating agent-based programming, in particular, Logo programming, with curricular science has been shown to be challenging in previous research…

  5. Knowledge Management in Role Based Agents

    Science.gov (United States)

    Kır, Hüseyin; Ekinci, Erdem Eser; Dikenelli, Oguz

    In multi-agent system literature, the role concept is getting increasingly researched to provide an abstraction to scope beliefs, norms, goals of agents and to shape relationships of the agents in the organization. In this research, we propose a knowledgebase architecture to increase applicability of roles in MAS domain by drawing inspiration from the self concept in the role theory of sociology. The proposed knowledgebase architecture has granulated structure that is dynamically organized according to the agent's identification in a social environment. Thanks to this dynamic structure, agents are enabled to work on consistent knowledge in spite of inevitable conflicts between roles and the agent. The knowledgebase architecture is also implemented and incorporated into the SEAGENT multi-agent system development framework.

  6. Agents-based distributed processes control systems

    Directory of Open Access Journals (Sweden)

    Adrian Gligor

    2011-12-01

    Full Text Available Large industrial distributed systems have revealed a remarkable development in recent years. We may note an increase of their structural and functional complexity, at the same time with those on requirements side. These are some reasons why there are involvednumerous researches, energy and resources to solve problems related to these types of systems. The paper addresses the issue of industrial distributed systems with special attention being given to the distributed industrial processes control systems. A solution for a distributed process control system based on mobile intelligent agents is presented.The main objective of the proposed system is to provide an optimal solution in terms of costs, maintenance, reliability and flexibility. The paper focuses on requirements, architecture, functionality and advantages brought by the proposed solution.

  7. AGENT BASED INTRUSION DETECTION SYSTEM IN MANET

    Directory of Open Access Journals (Sweden)

    J. K. Mandal

    2013-02-01

    Full Text Available In this paper a technique for intrusion detection in MANET has been proposed where agents are fired from a node which traverses each node randomly and detect the malicious node. Detection is based on triangular encryption technique (TE where AODV is taken as routing protocol. For simulation we have taken NS2 (2.33 where two type of parameters are considered out of which number of nodes and percentage of node mobility are the attributes. For analysis purpose 20, 30, 30, 40, 50 and 60 nodes are taken with a variable percentage of malicious node as 0 %( no malicious, 10%, 20%, 30% and 40%. Analysis have been done taking generated packets, forwarded packets, delay, and average delay as parameters

  8. An Active Learning Exercise for Introducing Agent-Based Modeling

    Science.gov (United States)

    Pinder, Jonathan P.

    2013-01-01

    Recent developments in agent-based modeling as a method of systems analysis and optimization indicate that students in business analytics need an introduction to the terminology, concepts, and framework of agent-based modeling. This article presents an active learning exercise for MBA students in business analytics that demonstrates agent-based…

  9. An Agent-Based Analysis of Tax Compliance for Turkey

    OpenAIRE

    M. Oguz ARSLAN; Ozgur Ican

    2013-01-01

    An agent-based tax compliance model for Turkey is developed in this paper. In this model, four kinds of agent archetypes as honest, strategic, defiant, and random are employed. The model is used for simulating evolutionary changes in tax compliance behavior of a population of 10,000 taxpayer agents. The implementation of the model via four simulation scenarios points out that an agent-based evolutionary strategy simulation for Turkish case is valid. Also, the neighbourhood effect is not found...

  10. Agent-based argumentation for ontology alignments

    OpenAIRE

    Laera, Loredana; Tamma, Valentina; Bench-Capon, Trevor; Euzenat, Jérôme

    2006-01-01

    laera2006a International audience When agents communicate they do not necessarily use the same vocabulary or ontology. For them to interact successfully they must find correspondences between the terms used in their ontologies. While many proposals for matching two agent ontologies have been presented in the literature, the resulting alignment may not be satisfactory to both agents and can become the object of further negotiation between them. This paper describes our work constructing ...

  11. Decentralized network management based on mobile agent

    Institute of Scientific and Technical Information of China (English)

    李锋; 冯珊

    2004-01-01

    The mobile agent technology can be employed effectively for the decentralized management of complex networks. We show how the integration of mobile agent with legacy management protocol, such as simple network management protocol (SNMP), leads to decentralized management architecture. HostWatcher is a framework that allows mobile agents to roam network, collect and process data, and perform certain adaptive actions. A prototype system is built and a quantitative analysis underlines the benefits in respect to reducing network load.

  12. Agent-Based Health Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose combination of software intelligent agents to achieve decentralized reasoning, with fault detection and diagnosis using PCA, neural nets, and maximum...

  13. Recent advances in agent-based complex automated negotiation

    CERN Document Server

    Ito, Takayuki; Zhang, Minjie; Fujita, Katsuhide; Robu, Valentin

    2016-01-01

    This book covers recent advances in Complex Automated Negotiations as a widely studied emerging area in the field of Autonomous Agents and Multi-Agent Systems. The book includes selected revised and extended papers from the 7th International Workshop on Agent-Based Complex Automated Negotiation (ACAN2014), which was held in Paris, France, in May 2014. The book also includes brief introductions about Agent-based Complex Automated Negotiation which are based on tutorials provided in the workshop, and brief summaries and descriptions about the ANAC'14 (Automated Negotiating Agents Competition) competition, where authors of selected finalist agents explain the strategies and the ideas used by them. The book is targeted to academic and industrial researchers in various communities of autonomous agents and multi-agent systems, such as agreement technology, mechanism design, electronic commerce, related areas, as well as graduate, undergraduate, and PhD students working in those areas or having interest in them.

  14. Protonated diamines as anion-binding agents and their utility in capillary electrophoresis separations.

    Science.gov (United States)

    Noblitt, Scott D; Speights, Rachel M; Henry, Charles S

    2011-11-01

    Capillary zone electrophoresis is a proven method for separating small ions because of the inherent charge and differences in mobility of these analytes. Despite its resolving power, CZE can be insufficient for separating ions with similar mobilities. One remedy is to modify mobilities via the addition of background electrolyte complexation agents. However, this approach is not straightforward for inorganic anions, which lack complexation options. To address this shortfall, the diprotonated diamine moiety was investigated for complexation of dianions. Dicationic diamines significantly complexed dianions, and this interaction was not purely electrostatic in nature because affinities varied with dianion identity. Aqueous association constants were measured with affinity capillary electrophoresis (ACE) and found to be similar in magnitude but different in selectivity to those of dianions with magnesium ion. Binding was also investigated for zwitterionic buffers containing the protonated diamine moiety. Zwitterions exhibited binding constants as high as 18 M(-1) (30-mM ionic strength). This work discusses the observed binding constants and their potential usefulness in CZE separations of inorganic anions. Also covered are improvements to ACE methodology and an evaluation of some of the assumptions employed. PMID:22002837

  15. Validating agent based models through virtual worlds.

    Energy Technology Data Exchange (ETDEWEB)

    Lakkaraju, Kiran; Whetzel, Jonathan H.; Lee, Jina; Bier, Asmeret Brooke; Cardona-Rivera, Rogelio E.; Bernstein, Jeremy Ray Rhythm

    2014-01-01

    As the US continues its vigilance against distributed, embedded threats, understanding the political and social structure of these groups becomes paramount for predicting and dis- rupting their attacks. Agent-based models (ABMs) serve as a powerful tool to study these groups. While the popularity of social network tools (e.g., Facebook, Twitter) has provided extensive communication data, there is a lack of ne-grained behavioral data with which to inform and validate existing ABMs. Virtual worlds, in particular massively multiplayer online games (MMOG), where large numbers of people interact within a complex environ- ment for long periods of time provide an alternative source of data. These environments provide a rich social environment where players engage in a variety of activities observed between real-world groups: collaborating and/or competing with other groups, conducting battles for scarce resources, and trading in a market economy. Strategies employed by player groups surprisingly re ect those seen in present-day con icts, where players use diplomacy or espionage as their means for accomplishing their goals. In this project, we propose to address the need for ne-grained behavioral data by acquiring and analyzing game data a commercial MMOG, referred to within this report as Game X. The goals of this research were: (1) devising toolsets for analyzing virtual world data to better inform the rules that govern a social ABM and (2) exploring how virtual worlds could serve as a source of data to validate ABMs established for analogous real-world phenomena. During this research, we studied certain patterns of group behavior to compliment social modeling e orts where a signi cant lack of detailed examples of observed phenomena exists. This report outlines our work examining group behaviors that underly what we have termed the Expression-To-Action (E2A) problem: determining the changes in social contact that lead individuals/groups to engage in a particular behavior

  16. An Agent-Based Data Mining System for Ontology Evolution

    Science.gov (United States)

    Hadzic, Maja; Dillon, Darshan

    We have developed an evidence-based mental health ontological model that represents mental health in multiple dimensions. The ongoing addition of new mental health knowledge requires a continual update of the Mental Health Ontology. In this paper, we describe how the ontology evolution can be realized using a multi-agent system in combination with data mining algorithms. We use the TICSA methodology to design this multi-agent system which is composed of four different types of agents: Information agent, Data Warehouse agent, Data Mining agents and Ontology agent. We use UML 2.1 sequence diagrams to model the collaborative nature of the agents and a UML 2.1 composite structure diagram to model the structure of individual agents. The Mental Heath Ontology has the potential to underpin various mental health research experiments of a collaborative nature which are greatly needed in times of increasing mental distress and illness.

  17. Agent-based models and individualism: is the world agent-based?

    OpenAIRE

    O'Sullivan, D.; Haklay, M.

    2000-01-01

    Agent-based models (ABMs) are an increasingly popular tool in the social sciences. This trend seems likely to continue, so that they will become widely used in geography and in urban and regional planning. We present an overview of examples of these models in the life sciences, economics, planning, sociology, and archaeology. We conclude that ABMs strongly tend towards an individualist view of the social world. This point is reinforced by closer consideration of particular examples. This disc...

  18. Mobile Agent Based on Internet%基于Internet的移动Agent

    Institute of Scientific and Technical Information of China (English)

    徐练; 周龙骧; 王翰虎

    2001-01-01

    Mobile Agent is a hybrid of Internet technology and Artificial Intelligence. Today there are tremendous amount of information resources distributing among Internet ,but it's very difficult to find the wanted-thing. Internet has increasingly become a vital compute platform for electron commercial which has highly popular through the world. Developing new Internet-based application programs such as shopping online,e-business,search engine etc pose new task. Mobile Agent proffers new clue and technology. Considering Internet,this thesis conducts a research on architecture,mobile mechanism in mobile Agent system. Based on the Agent theory research and engineering ,the thesis focuses point at researching Mobile Agents,which have the ability to rove through the network. Using OMG's "Mobile Agent Facility Specification" for reference,we design a model architecture of Mobile Agent System. Based on the architecture ,the article analyzes the key technology and gives methods to resolving them ,emphases on mobility mechanism of Agent and implementing it. At last a model of java-based Mobile Agent System is given.

  19. Cement industry control system based on multi agent

    Institute of Scientific and Technical Information of China (English)

    王海东; 邱冠周; 黄圣生

    2004-01-01

    Cement production is characterized by its great capacity, long-time delay, multi variables, difficult measurement and muhi disturbances. According to the distributed intelligent control strategy based on the multi agent, the multi agent control system of cement production is built, which includes integrated optimal control and diagnosis control. The distributed and multiple level structure of multi agent system for the cement control is studied. The optimal agent is in the distributed state, which aims at the partial process of the cement production, and forms the optimal layer. The diagnosis agent located on the diagnosis layer is the diagnosis unit which aims at the whole process of the cement production, and the central management unit of the system. The system cooperation is realized by the communication among optimal agents and diagnosis agent. The architecture of the optimal agent and the diagnosis agent are designed. The detailed functions of the optimal agent and the diagnosis agent are analyzed.At last the realization methods of the agents are given, and the application of the multi agent control system is presented. The multi agent system has been successfully applied to the off-line control of one cement plant with capacity of 5 000 t/d. The results show that the average yield of the clinker increases 9.3% and the coal consumption decreases 7.5 kg/t.

  20. An Agent Operationalization Approach for Context Specific Agent-Based Modeling

    OpenAIRE

    Christof Knoeri; Binder, Claudia R.; Hans-Joerg Althaus

    2011-01-01

    The potential of agent-based modeling (ABM) has been demonstrated in various research fields. However, three major concerns limit the full exploitation of ABM; (i) agents are too simple and behave unrealistically without any empirical basis, (ii) 'proof of concept' applications are too theoretical and (iii) too much value placed on operational validity instead of conceptual validity. This paper presents an operationalization approach to determine the key system agents, their interaction, deci...

  1. Agent Based Processing of Global Evaluation Function

    CERN Document Server

    Hossain, M Shahriar; Joarder, Md Mahbubul Alam

    2011-01-01

    Load balancing across a networked environment is a monotonous job. Moreover, if the job to be distributed is a constraint satisfying one, the distribution of load demands core intelligence. This paper proposes parallel processing through Global Evaluation Function by means of randomly initialized agents for solving Constraint Satisfaction Problems. A potential issue about the number of agents in a machine under the invocation of distribution is discussed here for securing the maximum benefit from Global Evaluation and parallel processing. The proposed system is compared with typical solution that shows an exclusive outcome supporting the nobility of parallel implementation of Global Evaluation Function with certain number of agents in each invoked machine.

  2. A generic testing framework for agent-based simulation models

    OpenAIRE

    Gürcan, Önder; Dikenelli, Oguz; Bernon, Carole

    2013-01-01

    International audience Agent-based modelling and simulation (ABMS) had an increasing attention during the last decade. However, the weak validation and verification of agent-based simulation models makes ABMS hard to trust. There is no comprehensive tool set for verification and validation of agent-based simulation models, which demonstrates that inaccuracies exist and/or reveals the existing errors in the model. Moreover, on the practical side, many ABMS frameworks are in use. In this sen...

  3. Agent Based Modelling and Simulation of Social Processes

    OpenAIRE

    Armano Srbljinovic; Ognjen Skunca

    2003-01-01

    The paper provides an introduction to agent-based modelling and simulation of social processes. Reader is introduced to the worldview underlying agent-based models, some basic terminology, basic properties of agent-based models, as well as to what one can and what cannot expect from such models, particularly when they are applied to social-scientific investigation. Special attention is given to the issues of validation. Classification-ACM-1998: J.4 [Computer Applications]; Social and behavior...

  4. Agent-Based Medical Diagnosis Systems

    OpenAIRE

    Barna László Iantovics

    2012-01-01

    Medical diagnostics elaboration many times is a distributed and cooperative work, which involves more medical human specialists and different medical systems. Recent results described in the literature prove that medical diagnosis problems can be solved efficiently by large-scale medical multi-agent systems. Cooperative diagnosing of medical diagnosis problems by large-scale multi-agent systems makes the diagnoses elaborations easier and may increase the accuracy of elaborated diagnostics. Th...

  5. An Interactive Tool for Creating Multi-Agent Systems and Interactive Agent-based Games

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Pagliarini, Luigi

    2011-01-01

    Utilizing principles from parallel and distributed processing combined with inspiration from modular robotics, we developed the modular interactive tiles. As an educational tool, the modular interactive tiles facilitate the learning of multi-agent systems and interactive agent-based games. The...... modular and physical property of the tiles provides students with hands-on experience in exploring the theoretical aspects underlying multi-agent systems which often appear as challenging to students. By changing the representation of the cognitive challenging aspects of multi-agent systems education to a...

  6. An Interactive Tool for Creating Multi-Agent Systems and Interactive Agent-based Games

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Pagliarini, Luigi

    2011-01-01

    Utilizing principles from parallel and distributed processing combined with inspiration from modular robotics, we developed the modular interactive tiles. As an educational tool, the modular interactive tiles facilitate the learning of multi-agent systems and interactive agent-based games. The...

  7. Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction.

    Science.gov (United States)

    Adam, Rosa; Bilbao-Ramos, Pablo; López-Molina, Sonia; Abarca, Belén; Ballesteros, Rafael; González-Rosende, M Eugenia; Dea-Ayuela, M Auxiliadora; Alzuet-Piña, Gloria

    2014-08-01

    A new series of triazolopyridyl pyridyl ketones has been synthetized by regioselective lithiation of the corresponding [1,2,3]triazolo[1,5-a]pyridine at 7 position followed by reaction with different electrophiles. The in vitro antileishmanial activity of these compounds was evaluated against Leishmaniainfantum, Leishmaniabraziliensis, Leishmaniaguyanensis and Leishmaniaamazonensis. Compounds 6 and 7 were found to be the most active leishmanicidal agents. Both of them showed activities at micromolar concentration against cultured promastigotes of Leishmania spp. (IC₅₀=99.8-26.8 μM), without cytotoxicity on J774 macrophage cells. These two compounds were also tested in vivo in a murine model of acute infection by L. infantum. The triazolopyridine derivative 6 was effective against both spleen and liver parasites forms, while 7 was inactive against liver parasites. Mechanistic aspects of the antileishmanial activity were investigated by means of DNA binding studies (UV-titration and viscosimetry). Results have revealed that these active ligands are able to interact strongly with DNA [Kb=1.14 × 10(5)M(-1) (6) and 3.26 × 10(5)M(-1) (7)]. Moreover, a DNA groove binding has been proposed for both 6 and 7. To provide more insight on the mode of action of compounds 6 and 7 under biological conditions, their interaction with bovine serum albumin (BSA) was monitored by fluorescence titrations and UV-visible spectroscopy. The quenching constants and binding parameters were determined. Triazolopyridine ketones 6 and 7 have exhibited significant affinity towards BSA [Kb=2.5 × 10(4)M(-1) (6) and 1.9 × 10(4)M(-1) (7)]. Finally, to identify the binding location of compounds 6 and 7 on the BSA, competitive binding experiments were carried out, using warfarin, a characteristic marker for site I, and ibuprofen as one for site II. Results derived from these studies have indicated that both compounds interact at BSA site I and, to a lesser extent, at site II. PMID:24953952

  8. Binding of anti-prion agents to glycosaminoglycans: Evidence from electronic absorption and circular dichroism spectroscopy

    International Nuclear Information System (INIS)

    The polyanionic glycosaminoglycans (GAGs) are intimately involved in the pathogenesis of protein conformational disorders such as amyloidosis and prion diseases. Several cationic agents are known to exhibit anti-prion activity but their mechanism of action is poorly understood. In this study, UV absorption and circular dichroism (CD) spectroscopic techniques were used to investigate the interaction between heparin and chondroitin-6-sulfate and anti-prion drugs including acridine, quinoline, and phenothiazine derivatives. UV band hypochromism of (±)-quinacrine, (±)-primaquine, tacrine, quinidine, chlorpromazine, and induced CD spectra of (±)-quinacrine upon addition of GAGs provided evidence for the GAG binding of these compounds. The association constants (∼106-107 M-1) estimated from the UV titration curves show high-affinity drug-heparin interactions. Ionic strength-dependence of the absorption spectra suggested that the interaction between GAGs and the cationic drugs is principally electrostatic in nature. Drug binding differences of heparin and chondroitin-6-sulfate were attributed to their different negative charge density. These results call the attention to the alteration of GAG-prion/GAG-amyloid interactions by which these compounds might exert their anti-prion/anti-amyloidogenic activities

  9. Agent Community based Peer-to-Peer Information Retrieval

    Science.gov (United States)

    Mine, Tsunenori; Matsuno, Daisuke; Amamiya, Makoto

    This paper proposes an agent community based information retrieval method, which uses agent communities to manage and look up information related to users. An agent works as a delegate of its user and searches for information that the user wants by communicating with other agents. The communication between agents is carried out in a peer-to-peer computing architecture. In order to retrieve information related to a user query, an agent uses two histories : a query/retrieved document history(Q/RDH) and a query/sender agent history(Q/SAH). The former is a list of pairs of a query and retrieved documents, where the queries were sent by the agent itself. The latter is a list of pairs of a query and sender agents and shows ``who sent what query to the agent''. This is useful to find a new information source. Making use of the Q/SAH is expected to cause a collaborative filtering effect, which gradually creates virtual agent communities, where agents with the same interests stay together. Our hypothesis is that a virtual agent community reduces communication loads to perform a search. As an agent receives more queries, then more links to new knowledge are achieved. From this behavior, a ``give and take''(or positive feedback) effect for agents seems to emerge. We implemented this method with Multi-Agents Kodama which has been developed in our laboratory, and conducted preliminary experiments to test the hypothesis. The empirical results showed that the method was much more efficient than a naive method employing 'broadcast' techniques only to look up a target agent.

  10. Modeling collective emotions: a stochastic approach based on Brownian agents

    International Nuclear Information System (INIS)

    We develop a agent-based framework to model the emergence of collective emotions, which is applied to online communities. Agents individual emotions are described by their valence and arousal. Using the concept of Brownian agents, these variables change according to a stochastic dynamics, which also considers the feedback from online communication. Agents generate emotional information, which is stored and distributed in a field modeling the online medium. This field affects the emotional states of agents in a non-linear manner. We derive conditions for the emergence of collective emotions, observable in a bimodal valence distribution. Dependent on a saturated or a super linear feedback between the information field and the agent's arousal, we further identify scenarios where collective emotions only appear once or in a repeated manner. The analytical results are illustrated by agent-based computer simulations. Our framework provides testable hypotheses about the emergence of collective emotions, which can be verified by data from online communities. (author)

  11. Novel insights in agent-based complex automated negotiation

    CERN Document Server

    Lopez-Carmona, Miguel; Ito, Takayuki; Zhang, Minjie; Bai, Quan; Fujita, Katsuhide

    2014-01-01

    This book focuses on all aspects of complex automated negotiations, which are studied in the field of autonomous agents and multi-agent systems. This book consists of two parts. I: Agent-Based Complex Automated Negotiations, and II: Automated Negotiation Agents Competition. The chapters in Part I are extended versions of papers presented at the 2012 international workshop on Agent-Based Complex Automated Negotiation (ACAN), after peer reviews by three Program Committee members. Part II examines in detail ANAC 2012 (The Third Automated Negotiating Agents Competition), in which automated agents that have different negotiation strategies and are implemented by different developers are automatically negotiated in the several negotiation domains. ANAC is an international competition in which automated negotiation strategies, submitted by a number of universities and research institutes across the world, are evaluated in tournament style. The purpose of the competition is to steer the research in the area of bilate...

  12. The Gap of Current Agent Based Simulation Modeling Practices and Feasibility of a Generic Agent Based Simulation Model

    OpenAIRE

    Yim Ling Loo; Alicia Y.C. Tang; Azhana Ahmad

    2015-01-01

    Agent-based modeling had been revolving to be established approach in modeling simulation systems which are used to understand and predict certain real-life scenarios in specific domains. Past researches which are domain-specific caused repetitive building of new models from scratch and restrict replication and reuse because of limitation of models’ description. This paper presents a review of gaps between domain-specific agent-based simulation modeling and the recent practices of agent-based...

  13. Volatility clustering in agent based market models

    Science.gov (United States)

    Giardina, Irene; Bouchaud, Jean-Philippe

    2003-06-01

    We define and study a market model, where agents have different strategies among which they can choose, according to their relative profitability, with the possibility of not participating to the market. The price is updated according to the excess demand, and the wealth of the agents is properly accounted for. Only two parameters play a significant role: one describes the impact of trading on the price, and the other describes the propensity of agents to be trend following or contrarian. We observe three different regimes, depending on the value of these two parameters: an oscillating phase with bubbles and crashes, an intermittent phase and a stable ‘rational’ market phase. The statistics of price changes in the intermittent phase resembles that of real price changes, with small linear correlations, fat tails and long-range volatility clustering. We discuss how the time dependence of these two parameters spontaneously drives the system in the intermittent region.

  14. Multi-agent based cooperative search in combinatorial optimisation

    OpenAIRE

    Martin, Simon

    2013-01-01

    Cooperative search provides a class of strategies to design more effective search methodologies by combining (meta-) heuristics for solving combinatorial optimisation problems. This area has been little explored in operational research. This thesis proposes a general agent-based distributed framework where each agent implements a (meta-) heuristic. An agent continuously adapts itself during the search process using a cooperation protocol based on reinforcement learning and pattern matching. G...

  15. Multi-Agent Reinforcement Learning Algorithm Based on Action Prediction

    Institute of Scientific and Technical Information of China (English)

    TONG Liang; LU Ji-lian

    2006-01-01

    Multi-agent reinforcement learning algorithms are studied. A prediction-based multi-agent reinforcement learning algorithm is presented for multi-robot cooperation task. The multi-robot cooperation experiment based on multi-agent inverted pendulum is made to test the efficency of the new algorithm, and the experiment results show that the new algorithm can achieve the cooperation strategy much faster than the primitive multiagent reinforcement learning algorithm.

  16. Social scientists, qualitative data, and agent-based modeling

    OpenAIRE

    Seidl, Roman

    2014-01-01

    Empirical data obtained with social science methods can be useful for informing agent-based models, for instance, to fix the profile of heterogeneous agents or to specify behavioral rules. For the latter in particular, qualitative methods that investigate the details of individual decision processes are an option. In this paper, I highlight the challenges for social scientists who investigate social/psychological phenomena but at the same time have to consider the properties of agent-based si...

  17. Ad Hoc Protocols Via Multi Agent Based Tools

    OpenAIRE

    Ali Bazghandi; Mehdi Bazghandi

    2011-01-01

    The purpose of this paper is investigating behaviors of Ad Hoc protocols in Agent-based simulation environments. First we bring brief introduction about agents and Ad Hoc networks. We introduce some agent-based simulation tools like NS-2. Then we focus on two protocols, which are Ad Hoc On-demand Multipath Distance Vector (AODV) and Destination Sequenced Distance Vector (DSDV). At the end, we bring simulation results and discuss about their reasons.

  18. Container Terminal Operations Modeling through Multi agent based Simulation

    OpenAIRE

    Ayub, Yasir; Faruki, Usman

    2009-01-01

    This thesis aims to propose a multi-agent based hierarchical model for the operations of container terminals. We have divided our model into four key agents that are involved in each sub processes. The proposed agent allocation policies are recommended for different situations that may occur at a container terminal. A software prototype is developed which implements the hierarchical model. This web based application is used in order to simulate the various processes involved in the following ...

  19. An Emotional Agent Model Based on Granular Computing

    Directory of Open Access Journals (Sweden)

    Jun Hu

    2012-01-01

    Full Text Available Affective computing has a very important significance for fulfilling intelligent information processing and harmonious communication between human being and computers. A new model for emotional agent is proposed in this paper to make agent have the ability of handling emotions, based on the granular computing theory and the traditional BDI agent model. Firstly, a new emotion knowledge base based on granular computing for emotion expression is presented in the model. Secondly, a new emotional reasoning algorithm based on granular computing is proposed. Thirdly, a new emotional agent model based on granular computing is presented. Finally, based on the model, an emotional agent for patient assistant in hospital is realized, experiment results show that it is efficient to handle simple emotions.

  20. MOBILE BUSINESS APPROACH BASED ON MOBILE AGENT

    Directory of Open Access Journals (Sweden)

    Ahmed Aloui

    2011-01-01

    Full Text Available Users today want the opportunity to make (or manage a businesses in anytime and anywhere via their mobile devices. This paper proposes the architecture with mobile agent for the mobile businesses (m-business. M-business appeared as the promising approach to drive the vague following one of electronic business (e-business. Most of the e-busines [9] applications uses the traditional model client/server in which a commercial operation requires generally a link of stable communication being established between the customer and the server, and the traditional approach client/server [8] constitutes an obstacle to the development of application of m-business. The proposed architecture introduces several advantages: in the first place, allow the consumers to manage their commercial business driven by types of mobile devices (phones, PDAs, etc. .... at any time and wherever. Secondly, minimize the waiting time of the customer, and the quantity of transferring information. Third, this architecture addresses the problem of time limited and expensive connection for mobile users. The Mobile agents will be used on a single level: research agent. Every research mobile agent will be used to visit the target server site of the application to collect the information’s for his client, which allows it to interact locally with a server, and so to reduce the traffic on the network by transmitting only the useful data.

  1. Agent Types and Structures based on Analysis of Building Design

    DEFF Research Database (Denmark)

    Hartvig, Susanne C

    Based on an anaysis of building design an initial division of design agent into five classes: information collectors, generators, modifiers amd evaluators is presented.......Based on an anaysis of building design an initial division of design agent into five classes: information collectors, generators, modifiers amd evaluators is presented....

  2. The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography

    Science.gov (United States)

    Nettles, James H.; Downing, Kenneth H.

    Since tubulin was discovered in 1967, drug probes have been used to manipulate mechanisms of microtubule polymerization and disassembly. In parallel, advances in optical imagery, electron microscopy, along with both electron and X-ray diffraction have provided ability to "see" the molecular underpinning of these machines. Nanoscale mapping of different tubulin polymers formed in the presence of different drugs and cofactors provide a context for examining the dynamic features relevant to their biological activity. Models built from EM maps have been used to understand the binding of stabilizing drugs such as taxanes and epothilones, to predict more effective molecules, and to explain mutation based resistance. Here, we discuss drug binding in the context of different polymeric forms and propose a trigger mechanism associated with microtubules' dynamic instability.

  3. Agent-Based Decentralized Control Method for Islanded Microgrids

    DEFF Research Database (Denmark)

    Li, Qiang; Chen, Feixiong; Chen, Minyou;

    2016-01-01

    In this paper, an agent-based decentralized control model for islanded microgrids is proposed, which consists of a two-layer control structure. The bottom layer is the electrical distribution microgrid, while the top layer is the communication network composed of agents. An agent is regarded...... is processed according to control laws, agents adjust the production of distributed generators to which they connect. The main contributions of this paper are (i) an agent-based model for decentralized secondary control is introduced and the rules to establish the communication network are given; (ii...... agents use the proposed control laws. Finally, the simulation results show that frequency and voltage fluctuations are small and meet the requirements....

  4. Multi-Agent Based PGP Architecture

    Directory of Open Access Journals (Sweden)

    Babak Nouri-Moghaddam

    2014-03-01

    Full Text Available Pretty Good Privacy (PGP is a package for securing emails, files communications. It is an open-source package, which is available online for users. PGP provides some of the most important security services like Authentication, Confidentiality, and Integrity. PGP Also applies compression techniques for compressing messages and reducing their size. Also it uses Radix-64 encoding/decoding scheme for email compatibility. The classic PGP has been formed by independent components and uses a hierarchal structure in which each component is responsible for providing one of the services or features in PGP. This hierarchal structure forces all the components, even the independent ones to be executed in a linear way. Because of this structure, each component waits idle for long a time. As a result, the classic PGP has low performance and high execution time. By studying this structure, we find out that we can redesign the architecture by using Multi-Agent systems to eliminate bottlenecks. With this new design, we can achieve higher performance and faster execution time than the classic PGP. In the proposed scheme, each Agent handles one of the PGP's components and in the implementation semaphores will be used to handle each agent. By using this technique, we will have concurrency between the agents and as a result the idle time will decrease and the proposed scheme will get higher performance and lower execution time than the classic PGP. The experimental results show that our scheme runs 30% faster than the classic PGP with different configurations of computer hardware.

  5. Networks based on collisions among mobile agents

    CERN Document Server

    Gonz'alez, M C; Herrmann, H J; Gonz\\'alez, Marta C.; Lind, Pedro G.; Herrmann, Hans J.

    2006-01-01

    We investigate in detail a recent model of colliding mobile agents [Phys. Rev. Lett.~96, 088702], used as an alternative approach to construct evolving networks of interactions formed by the collisions governed by suitable dynamical rules. The system of mobile agents evolves towards a quasi-stationary state which is, apart small fluctuations, well characterized by the density of the system and the residence time of the agents. The residence time defines a collision rate and by varying the collision rate, the system percolates at a critical value, with the emergence of a giant cluster whose critical exponents are the ones of two-dimensional percolation. Further, the degree and clustering coefficient distributions and the average path length show that the network associated with such a system presents non-trivial features which, depending on the collision rule, enables one not only to recover the main properties of standard networks, such as exponential, random and scale-free networks, but also to obtain other ...

  6. A multi-agent based Tourism Kiosk on Internet

    OpenAIRE

    Yeung, CSK; Tung, PF; Yen, JCH

    1998-01-01

    We discuss the implementation of a multi agent based Tourism Kiosk for Hong Kong tourism industry on the Internet. This system allows the users to retrieve the most updated information about Hong Kong through any Java enabled Web browser. The complete system consists of a set of software agents who handle various information categories, such as hotels, shopping centres, and cinemas, etc. The Knowledge Query and Manipulation Language (KQML) was selected as the agent communication language to d...

  7. Multi Agent System Based Wide Area Protection against Cascading Events

    DEFF Research Database (Denmark)

    Liu, Zhou; Chen, Zhe; Liu, Leo;

    2012-01-01

    In this paper, a multi-agent system based wide area protection scheme is proposed in order to prevent long term voltage instability induced cascading events. The distributed relays and controllers work as a device agent which not only executes the normal function automatically but also can be mod...... effectiveness of proposed protection strategy. The simulation results indicate that the proposed multi agent control system can effectively coordinate the distributed relays and controllers to prevent the long term voltage instability induced cascading events....

  8. Agent-based transportation planning compared with scheduling heuristics

    OpenAIRE

    Mes, MRK Martijn; Heijden, van der, T.G.C.; Harten, van, W.H.

    2004-01-01

    Here we consider the problem of dynamically assigning vehicles to transportation orders that have di¤erent time windows and should be handled in real time. We introduce a new agent-based system for the planning and scheduling of these transportation networks. Intelligent vehicle agents schedule their own routes. They interact with job agents, who strive for minimum transportation costs, using a Vickrey auction for each incoming order. We use simulation to compare the on-time delivery percenta...

  9. Tutorial on agent-based modeling and simulation. Part 2 : how to model with agents.

    Energy Technology Data Exchange (ETDEWEB)

    Macal, C. M.; North, M. J.; Decision and Information Sciences

    2006-01-01

    Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of interacting autonomous agents. ABMS promises to have far-reaching effects on the way that businesses use computers to support decision-making and researchers use electronic laboratories to do research. Some have gone so far as to contend that ABMS is a new way of doing science. Computational advances make possible a growing number of agent-based applications across many fields. Applications range from modeling agent behavior in the stock market and supply chains, to predicting the spread of epidemics and the threat of bio-warfare, from modeling the growth and decline of ancient civilizations to modeling the complexities of the human immune system, and many more. This tutorial describes the foundations of ABMS, identifies ABMS toolkits and development methods illustrated through a supply chain example, and provides thoughts on the appropriate contexts for ABMS versus conventional modeling techniques.

  10. Medical Processes Agent-Based Critiquing System

    Czech Academy of Sciences Publication Activity Database

    Bošanský, Branislav

    Praha : Ústav informatiky AV ČR, v. v. i. & MATFYZPRESS, 2009 - (Kuželová, D.), 5-11 ISBN 978-80-7378-087-6. [Doktorandské dny 2009 Ústavu informatiky AV ČR, v. v. i.. Jizerka (CZ), 21.09.2009-23.09.2009] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : medical processes * multi-agent systems * decosion support systems Subject RIV: IN - Informatics, Computer Science

  11. Towards an agent-oriented programming language based on Scala

    Science.gov (United States)

    Mitrović, Dejan; Ivanović, Mirjana; Budimac, Zoran

    2012-09-01

    Scala and its multi-threaded model based on actors represent an excellent framework for developing purely reactive agents. This paper presents an early research on extending Scala with declarative programming constructs, which would result in a new agent-oriented programming language suitable for developing more advanced, BDI agent architectures. The main advantage the new language over many other existing solutions for programming BDI agents is a natural and straightforward integration of imperative and declarative programming constructs, fitted under a single development framework.

  12. Migration control for mobile agents based on passport and visa

    OpenAIRE

    Guan, Su; T. Wang; Ong, SH

    2003-01-01

    Research on mobile agents has attracted much attention as this paradigm has demonstrated great potential for the next-generation e-commerce. Proper solutions to security-related problems become key factors in the successful deployment of mobile agents in e-commerce systems. We propose the use of passport and visa (P/V) for securing mobile agent migration across communities based on the SAFER e-commerce framework. P/V not only serves as up-to-date digital credentials for agent-host authentica...

  13. Complexity in Simplicity: Flexible Agent-based State Space Exploration

    DEFF Research Database (Denmark)

    Rasmussen, Jacob Illum; Larsen, Kim Guldstrand

    2007-01-01

    In this paper, we describe a new flexible framework for state space exploration based on cooperating agents. The idea is to let various agents with different search patterns explore the state space individually and communicate information about fruitful subpaths of the search tree to each other...

  14. Agent-Based Modeling: A Powerful Tool for Tourism Researchers

    NARCIS (Netherlands)

    Nicholls, Sarah; Amelung, B.; Student, Jillian

    2016-01-01

    Agent-based modeling (ABM) is a way of representing complex systems of autonomous agents or actors, and of simulating the multiple potential outcomes of these agents’ behaviors and interactions in the form of a range of alternatives or futures. Despite the complexity of the tourism system, and the p

  15. Complex between lignin and a Ti-based coupling agent

    DEFF Research Database (Denmark)

    Rasmussen, Jonas Stensgaard; Barsberg, Søren Talbro; Felby, Claus

    2014-01-01

    coating formulations would have a better performance if the adhesion to wood could be improved. In the present work, the chemical interaction between a titanium-based coupling agent, isopropyl triisostearoyl titanate (titanium agent, TA) and lignin has been studied by means of attenuated total reflectance...... between TA and lignin....

  16. An agent oriented information system: an MDA based development

    Directory of Open Access Journals (Sweden)

    Mohamed Sadgal

    2012-09-01

    Full Text Available Information systems (IS development should not only accomplish functional models but also conceptual models to represent the organizational environment in which it will have to evolve and must be aligned with strategic objectives. Generally, a significant innovations in the enterprise, is to organize its IS around its business processes. Otherwise, business models must be enriched by the agent paradigm to reduce the complexity involved in solving a problem by the structuring of knowledge on a set of intelligent agents, the association between agents and activities and collaboration among agents. To do this, we propose an agent oriented approach based on the model-driven-architecture (MDA for the information system development. This approach uses in its different phases, the BPMN language for the business processes modeling, AML language for the agent modeling, and JADEX platform for the implementation. The IS development is realized by different automated mappings from source models to target models.

  17. MODEL-BASED PERFORMANCE EVALUATION APPROACH FOR MOBILE AGENT SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Li Xin; Mi Zhengkun; Meng Xudong

    2004-01-01

    Claimed as the next generation programming paradigm, mobile agent technology has attracted extensive interests in recent years. However, up to now, limited research efforts have been devoted to the performance study of mobile agent system and most of these researches focus on agent behavior analysis resulting in that models are hard to apply to mobile agent systems. To bridge the gap, a new performance evaluation model derived from operation mechanisms of mobile agent platforms is proposed. Details are discussed for the design of companion simulation software, which can provide the system performance such as response time of platform to mobile agent. Further investigation is followed on the determination of model parameters. Finally comparison is made between the model-based simulation results and measurement-based real performance of mobile agent systems. The results show that the proposed model and designed software are effective in evaluating performance characteristics of mobile agent systems. The proposed approach can also be considered as the basis of performance analysis for large systems composed of multiple mobile agent platforms.

  18. Content Based Image Retrieval with Mobile Agents and Steganography

    OpenAIRE

    Thampi, Sabu M.; Sekaran, K. Chandra

    2004-01-01

    In this paper we present an image retrieval system based on Gabor texture features, steganography, and mobile agents.. By employing the information hiding technique, the image attributes can be hidden in an image without degrading the image quality. Thus the image retrieval process becomes simple. Java based mobile agents manage the query phase of the system. Based on the simulation results, the proposed system not only shows the efficiency in hiding the attributes but also provides other adv...

  19. Multi-agent Based Charges subsystem for Supply Chain Logistics

    Directory of Open Access Journals (Sweden)

    Pankaj Rani

    2012-05-01

    Full Text Available The main objective of this paper is to design charges subsystem using multi agent technology which deals with calculation, accrual and collection of various charges levied at the goods in a supply chain Logistics. Accrual of various charges such as freight, demurrage, and wharfage take place implicitly in the SC system at the various events of different subsystems which is collected and calculated by software agents. An Agent-based modeling is an approach based on the idea that a system is composed of decentralized individual ‘agents’ and that each agent interacts with other agents according to its localized knowledge. Our aim is to design a flexible architecture that can deal with next generation supply chain problems based on a multi-agent architecture. In this article, a multi agent system has been developed to calculate charges levied at various stages on good sheds.. Each entity is modeled as one agent and their coordination lead to control inventories and minimize the total cost of SC by sharing information and forecasting knowledge and using negotiation mechanism.

  20. Resource-efficient wireless monitoring based on mobile agent migration

    Science.gov (United States)

    Smarsly, Kay; Law, Kincho H.; König, Markus

    2011-04-01

    Wireless sensor networks are increasingly adopted in many engineering applications such as environmental and structural monitoring. Having proven to be low-cost, easy to install and accurate, wireless sensor networks serve as a powerful alternative to traditional tethered monitoring systems. However, due to the limited resources of a wireless sensor node, critical problems are the power-consuming transmission of the collected sensor data and the usage of onboard memory of the sensor nodes. This paper presents a new approach towards resource-efficient wireless sensor networks based on a multi-agent paradigm. In order to efficiently use the restricted computing resources, software agents are embedded in the wireless sensor nodes. On-board agents are designed to autonomously collect, analyze and condense the data sets using relatively simple yet resource-efficient algorithms. If having detected (potential) anomalies in the observed structural system, the on-board agents explicitly request specialized software agents. These specialized agents physically migrate from connected computer systems, or adjacent nodes, to the respective sensor node in order to perform more complex damage detection analyses based on their inherent expert knowledge. A prototype system is designed and implemented, deploying multi-agent technology and dynamic code migration, in a wireless sensor network for structural health monitoring. Laboratory tests are conducted to validate the performance of the agent-based wireless structural health monitoring system and to verify its autonomous damage detection capabilities.

  1. A structure-based model for predicting serum albumin binding.

    Directory of Open Access Journals (Sweden)

    Katrina W Lexa

    Full Text Available One of the many factors involved in determining the distribution and metabolism of a compound is the strength of its binding to human serum albumin. While experimental and QSAR approaches for determining binding to albumin exist, various factors limit their ability to provide accurate binding affinity for novel compounds. Thus, to complement the existing tools, we have developed a structure-based model of serum albumin binding. Our approach for predicting binding incorporated the inherent flexibility and promiscuity known to exist for albumin. We found that a weighted combination of the predicted logP and docking score most accurately distinguished between binders and nonbinders. This model was successfully used to predict serum albumin binding in a large test set of therapeutics that had experimental binding data.

  2. Agent-based Simulation of the Maritime Domain

    Directory of Open Access Journals (Sweden)

    O. Vaněk

    2010-01-01

    Full Text Available In this paper, a multi-agent based simulation platform is introduced that focuses on legitimate and illegitimate aspects of maritime traffic, mainly on intercontinental transport through piracy afflicted areas. The extensible architecture presented here comprises several modules controlling the simulation and the life-cycle of the agents, analyzing the simulation output and visualizing the entire simulated domain. The simulation control module is initialized by various configuration scenarios to simulate various real-world situations, such as a pirate ambush, coordinated transit through a transport corridor, or coastal fishing and local traffic. The environmental model provides a rich set of inputs for agents that use the geo-spatial data and the vessel operational characteristics for their reasoning. The agent behavior model based on finite state machines together with planning algorithms allows complex expression of agent behavior, so the resulting simulation output can serve as a substitution for real world data from the maritime domain.

  3. Agent-based method for distributed clustering of textual information

    Science.gov (United States)

    Potok, Thomas E. [Oak Ridge, TN; Reed, Joel W. [Knoxville, TN; Elmore, Mark T. [Oak Ridge, TN; Treadwell, Jim N. [Louisville, TN

    2010-09-28

    A computer method and system for storing, retrieving and displaying information has a multiplexing agent (20) that calculates a new document vector (25) for a new document (21) to be added to the system and transmits the new document vector (25) to master cluster agents (22) and cluster agents (23) for evaluation. These agents (22, 23) perform the evaluation and return values upstream to the multiplexing agent (20) based on the similarity of the document to documents stored under their control. The multiplexing agent (20) then sends the document (21) and the document vector (25) to the master cluster agent (22), which then forwards it to a cluster agent (23) or creates a new cluster agent (23) to manage the document (21). The system also searches for stored documents according to a search query having at least one term and identifying the documents found in the search, and displays the documents in a clustering display (80) of similarity so as to indicate similarity of the documents to each other.

  4. Information Fusion Using Ontology-Based Communication between Agents

    Directory of Open Access Journals (Sweden)

    Tarek Sobh

    2009-06-01

    Full Text Available The distribution of on-line applications among network nodes may require obtaining acceptable results from data analysis of multiple sensors. Such sensors data is probably heterogeneous, inconsistent, and of different types. Therefore, multiple sensor data fusion is required. Here, there are many levels of information fusion (from low level signals to high level knowledge. Agents for monitoring application field events could be used to dynamically react to those events and to take appropriate actions. In a dynamic environment even a single agent may have varying capabilities to sense that environment. The situation becomes more complex when various heterogeneous agents need to communicate with each other. Ontologies offer significant benefits to multi-agent systems. The benefits as such are interoperability, reusability, support for multi-agent systems development activities such as system analysis and agent knowledge modeling. Ontologies support multi-agent systems operations such as agent communication and reasoning. The proposed agent based model in this paper can afford a promising model for obtaining acceptable information in case of multiple sensors.

  5. Chitosan-based formulations of drugs, imaging agents and biotherapeutics

    NARCIS (Netherlands)

    Amidi, M.; Hennink, W.E.

    2010-01-01

    This preface is part of the Advanced Drug Delivery Reviews theme issue on “Chitosan-Based Formulations of Drugs, Imaging Agents and Biotherapeutics”. This special Advanced Drug Delivery Reviews issue summarizes recent progress and different applications of chitosanbased formulations.

  6. Agent-Based Modeling of Growth Processes

    Science.gov (United States)

    Abraham, Ralph

    2014-01-01

    Growth processes abound in nature, and are frequently the target of modeling exercises in the sciences. In this article we illustrate an agent-based approach to modeling, in the case of a single example from the social sciences: bullying.

  7. Agent-Based Collaborative Traffic Flow Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose agent-based game-theoretic approaches for simulation of strategies involved in multi-objective collaborative traffic flow management (CTFM). Intelligent...

  8. SICS MarketSpace: an agent-based market infrastructure

    OpenAIRE

    Eriksson, Joakim; Finne, Niclas; Janson, Sverker

    1998-01-01

    We present a simple and uniform communication framework for an agent-based market infrastructure, the goal of which is to enable automation of markets with self-interested participants distributed over the Internet.

  9. Pivotal Technology Research of Grid Based on Mobile Agent

    Institute of Scientific and Technical Information of China (English)

    CHEN Hong-wei; WANG Ru-chuan

    2004-01-01

    Grid Based on Mobile Agent is a new grid scheme. The purpose of the paper is to solve the pivotal technology of Grid Based on Mobile Agent ( GBMA) combined with thought of Virtual Organization ( VO). In GBMA, virtual organization is viewed as the basic management unit of the grid, and mobile agent is regarded as an important interactive means. Grid architecture, grid resource management and grid task management are the core technology problem of GBMA. The simulation results show that Inter- VO pattern has the obvious advantage because it can make full use of resources from other virtual organizations in GBMA environment.

  10. The fractional volatility model: An agent-based interpretation

    Science.gov (United States)

    Vilela Mendes, R.

    2008-06-01

    Based on the criteria of mathematical simplicity and consistency with empirical market data, a model with volatility driven by fractional noise has been constructed which provides a fairly accurate mathematical parametrization of the data. Here, some features of the model are reviewed and extended to account for leverage effects. Using agent-based models, one tries to find which agent strategies and (or) properties of the financial institutions might be responsible for the features of the fractional volatility model.

  11. Scalable, distributed data mining using an agent based architecture

    Energy Technology Data Exchange (ETDEWEB)

    Kargupta, H.; Hamzaoglu, I.; Stafford, B.

    1997-05-01

    Algorithm scalability and the distributed nature of both data and computation deserve serious attention in the context of data mining. This paper presents PADMA (PArallel Data Mining Agents), a parallel agent based system, that makes an effort to address these issues. PADMA contains modules for (1) parallel data accessing operations, (2) parallel hierarchical clustering, and (3) web-based data visualization. This paper describes the general architecture of PADMA and experimental results.

  12. Agent-based Models for Economic Policy Design

    OpenAIRE

    Dawid, Herbert; Neugart, Michael

    2010-01-01

    Agent-based simulation models are used by an increasing number of scholars as a tool for providing evaluations of economic policy measures and policy recommendations in complex environments. On the basis of recent work in this area we discuss the advantages of agent-based modeling for economic policy design and identify further needs to be addressed for strengthening this methodological approach as a basis for sound policy advice.

  13. The Promises and Perils of Agent-Based Computational Economics

    OpenAIRE

    Matteo Richiardi

    2004-01-01

    In this paper I analyse the main strengths and weaknesses of agent-based computational models. I first describe how agent-based simulations can complement more traditional modelling techniques. Then, I rationalise the main theoretical critiques against the use of simulation, which point to the following problematic areas: (i) interpretation of the simulation dynamics, (ii) estimation of the simulation model, and (iii) generalisation of the results. I show that there exist solutions for all th...

  14. Application of poly (ethyleneimine) solution as a binding agent in DGT technique for measurement of heavy metals in water.

    Science.gov (United States)

    Sui, Dian-Peng; Fan, Hong-Tao; Li, Jing; Li, You; Li, Qiong; Sun, Ting

    2013-09-30

    A 0.050 mol L(-1) solution of poly (ethyleneimine) (PEI), had been used as a novel binding agent of diffusive gradients in thin-films (DGT) technique (PEI-DGT) for measuring the concentrations of labile Cu(2+), Cd(2+) and Pb(2+) in waters. The binding capacities of the PEI-DGT for Cu(2+), Cd(2+) and Pb(2+) were 11.8, 10.2 and 10.6 μmol L(-1), respectively. The performance of PEI-DGT was independence of pH in the range of 4-8 and ionic strength in the range from 1×10(-4) to 0.1 mol L(-1) (as NaNO3). PEI-DGT could measure 104.7±5.2% of the total concentration of Cd(2+) (0.500 mg L(-1)), 95.2±4.3% of the total Cu(2+) (0.500 mg L(-1)) and 99.2±3.4% of the total Pb(2+) (0.500 mg L(-1)) in synthetic solution. Effects of the ligands on the measurement of labile metals were also investigated in synthetic solutions containing the various concentrations of EDTA and humic acid. In EDTA solution, the concentrations of labile metals measured by PEI-DGT showed good agreement with the theoretical concentrations of free metal ions. In humic acid solution, the concentrations of labile metals measured by PEI-DGT decreased with the increase of the concentrations of humic acid. Several DGT devices with various binding agents, including PEI, sodium polyacrylate and poly(4-styrenesulfonate) solution, were used for the measurement of labile fractions of Cu(2+), Cd(2+) and Pb(2+) in the spiked waters and in mine wastewaters. The results showed that the concentrations of labile metal measured by DGT devices with different binding agents could be significantly different, indicating that the labile fractions of metals were dependent on the binding strength of the binding agents with metals. By choosing binding agents, the useful information on the speciation and bioavailability of the analytes can be provided. PMID:23953471

  15. ACO Agent Based Routing in AOMDV Environment

    Directory of Open Access Journals (Sweden)

    Kaur Amanpreet

    2016-01-01

    Full Text Available Mobile Ad-hoc Network (MANET is a group of moving nodes which can communicate with each other without the help of any central stationary node. All the nodes in the MANET act as router for forwarding data packets. The nodes in the network also move randomly and there exists no fixed infrastructure. So, path breaks are the frequent problem in MANET. The routing protocol faces a lot of problem due these path breaks. Therefore, the routing protocol which is multipath in nature is more reliable than a unipath routing protocol. Ant colony optimization is a relatively new technique which is suitable for the optimization problems. AOMDV is a multipath routing protocol. Thus, if there happens to be path break, the packets can start following the new path which has already been selected. In this paper, we are trying to add ant’s agents into AOMDV behavior. In this way, the new protocol will be benefited by the dual properties i.e. of ant’s nature and multipath nature of AOMDV. The modified concept is simulated and the outcomes are compared with AOMDV, AODV and DSR routing protocols for few performance parameters. Results obtained are encouraging; the new algorithm performs better than traditional unipath and multipath routing protocols.

  16. Solidification of radioactive liquid waste - blast furnace slag as a binding agent

    International Nuclear Information System (INIS)

    During the reprocessing of spent Material Test Reactor (MTR) fuel elements from research reactor DIDO a radioactive waste solution is produced. Besides the radiotoxical elements, the waste solution contains aluminium from the cladding material of the spent fuel element and sodium hydroxide which is given to the acidic waste solution to reach a pH value between 12 and 13. After the neutralisation, the waste solution is solidified in a slag rich cement matrix. The final solidified product has to be assessed for a final disposal in a deep geological repository. One aspect of the assessment is related to intrinsic factors inherent to the solidified waste physical properties and the interaction between the binding agent and the waste solution. Another aspect of the safety assessment is related to the hydrolytic behaviour of the final cemented waste product under deep geological disposal conditions. The alkalinity of the waste solution acts as an activator for the hydration of the blast furnace slag. The rate of slag hydration decreases at late ages due to the formation of a denser microstructure of reaction products around the slag particles. The solidification of the waste solution with pure blast furnace slag and slag rich matrices leads to significant compressive strength. The effect is more marked for the waste solution cemented with only blast furnace slag. The solidification with blast furnace slag enables a physical immobilisation of the radiotoxical elements. In presence of MgCl2-rich salt brines, the solid waste matrice has no barrier function: the radiotoxical elements are released from the cement matrix within few months. Cs leaching behaviour shows no interaction with the cement matrix regardless of the pH in the surrounding aqueous phase. In contrast, a chemical interaction of Sr with the cement matrix can be identified for pH-value of leachant above 7. (orig.)

  17. Autonomous Traffic Control System Using Agent Based Technology

    CERN Document Server

    M, Venkatesh; V, Srinivas

    2011-01-01

    The way of analyzing, designing and building of real-time projects has been changed due to the rapid growth of internet, mobile technologies and intelligent applications. Most of these applications are intelligent, tiny and distributed components called as agent. Agent works like it takes the input from numerous real-time sources and gives back the real-time response. In this paper how these agents can be implemented in vehicle traffic management especially in large cities and identifying various challenges when there is a rapid growth of population and vehicles. In this paper our proposal gives a solution for using autonomous or agent based technology. These autonomous or intelligent agents have the capability to observe, act and learn from their past experience. This system uses the knowledge flow of precedent signal or data to identify the incoming flow of forthcoming signal. Our architecture involves the video analysis and exploration using some Intelligence learning algorithm to estimate and identify the...

  18. UML MODELING AND SYSTEM ARCHITECTURE FOR AGENT BASED INFORMATION RETRIEVAL

    Directory of Open Access Journals (Sweden)

    D. Muhammad Noorul Mubarak

    2015-12-01

    Full Text Available In this current technological era, there is an enormous increase in the information available on web and also in the online databases. This information abundance increases the complexity of finding relevant information. To solve such challenges, there is a need for improved and intelligent systems for efficient search and retrieval. Intelligent Agents can be used for better search and information retrieval in a document collection. The information required by a user is scattered in a large number of databases. In this paper, the object oriented modeling for agent based information retrieval system is presented. The paper also discusses the framework of agent architecture for obtaining the best combination terms that serve as an input query to the information retrieval system. The communication and cooperation among the agents are also explained. Each agent has a task to perform in information retrieval.

  19. Agent-Based Approaches for Behavioural Modelling in Military Simulations

    Directory of Open Access Journals (Sweden)

    Gaurav Chaudhary

    2015-12-01

    Full Text Available Behavioral modeling of combat entities in military simulations by creating synthetic agents in order to satisfy various battle scenarios is an important problem. The conventional modeling tools are not always sufficient to handle complex situations requiring adaptation. To deal with this Agent-Based Modeling (ABM is employed, as the agents exhibit autonomous behavior by adapting and varying their behavior during the course of the simulation whilst achieving the goals. Synthetic agents created by means of Computer Generated Force (CGF is a relatively recent approach to model behavior of combat entities for a more realistic training and effective military planning. CGFs, are also sometimes referred to as Semi- Automated Forces (SAF and enables to create high-fidelity simulations. Agents are used to control and augment the behavior of CGF entities, hence converting them into Intelligent CGF (ICGF. The intelligent agents can be modeled to exhibit cognitive abilities. For this review paper, extensive papers on stateof-the-art in agent-based modeling approaches and applications were surveyed. The paper assimilates issues involved in ABM with CGF as an important component of it. It reviews modeling aspects with respect to the interrelationship between ABM and CGF, which is required to carry out behavioral modeling. Important CGFs have been examined and a list with their significant features is given. Another issue that has been reviewed is that how the synthetic agents having different capabilities are implemented at different battle levels. Brief mention of state-of-the-art integrated cognitive architectures and a list of significant cognitive applications based on them with their features is given. At the same time, the maturity of ABM in agent-based applications has also been considered.

  20. A Rough Sets-based Agent Trust Management Framework

    Directory of Open Access Journals (Sweden)

    Sadra Abedinzadeh

    2013-03-01

    Full Text Available In a virtual society, which consists of several autonomous agents, trust helps agents to deal with the openness of the system by identifying the best agents capable of performing a specific task, or achieving a special goal. In this paper, we introduce ROSTAM, a new approach for agent trust management based on the theory of Rough Sets. ROSTAM is a generic trust management framework that can be applied to any types of multi agent systems. However, the features of the application domain must be provided to ROSTAM. These features form the trust attributes. By collecting the values for these attributes, ROSTAM is able to generate a set of trust rules by employing the theory of Rough Sets. ROSTAM then uses the trust rules to extract the set of the most trusted agents and forwards the user’s request to those agents only. After getting the results, the user must rate the interaction with each trusted agent. The rating values are subsequently utilized for updating the trust rules. We applied ROSTAM to the domain of cross-language Web search. The resulting Web search system recommends to the user the set of the most trusted pairs of translator and search engine in terms of the pairs that return the results with the highest precision of retrieval.

  1. The agent-based spatial information semantic grid

    Science.gov (United States)

    Cui, Wei; Zhu, YaQiong; Zhou, Yong; Li, Deren

    2006-10-01

    Analyzing the characteristic of multi-Agent and geographic Ontology, The concept of the Agent-based Spatial Information Semantic Grid (ASISG) is defined and the architecture of the ASISG is advanced. ASISG is composed with Multi-Agents and geographic Ontology. The Multi-Agent Systems are composed with User Agents, General Ontology Agent, Geo-Agents, Broker Agents, Resource Agents, Spatial Data Analysis Agents, Spatial Data Access Agents, Task Execution Agent and Monitor Agent. The architecture of ASISG have three layers, they are the fabric layer, the grid management layer and the application layer. The fabric layer what is composed with Data Access Agent, Resource Agent and Geo-Agent encapsulates the data of spatial information system so that exhibits a conceptual interface for the Grid management layer. The Grid management layer, which is composed with General Ontology Agent, Task Execution Agent and Monitor Agent and Data Analysis Agent, used a hybrid method to manage all resources that were registered in a General Ontology Agent that is described by a General Ontology System. The hybrid method is assembled by resource dissemination and resource discovery. The resource dissemination push resource from Local Ontology Agent to General Ontology Agent and the resource discovery pull resource from the General Ontology Agent to Local Ontology Agents. The Local Ontology Agent is derived from special domain and describes the semantic information of local GIS. The nature of the Local Ontology Agents can be filtrated to construct a virtual organization what could provides a global scheme. The virtual organization lightens the burdens of guests because they need not search information site by site manually. The application layer what is composed with User Agent, Geo-Agent and Task Execution Agent can apply a corresponding interface to a domain user. The functions that ASISG should provide are: 1) It integrates different spatial information systems on the semantic The Grid

  2. The effects of moisture content, particle size and binding agent content on oil palm shell pellet quality parameters

    Directory of Open Access Journals (Sweden)

    Nelson Arzola

    2012-04-01

    Full Text Available Waste-to-energy represents a challenge for the oil palm industry worldwide. Bio-pellet production is an alternative way of adding value to oil palm biomass. This would mean that a product having major energy density becomes more mechanically stable and achieves better performance during combustion. This paper deals with oil palm shell pelleting; using binding agents having up to 25% mass keeping average particle size less than 1mm and moisture content up to 18.7% (d.b. were evaluated. An experimental factorial design used binding agent mass percentage, milled shell particle size and moisture content as factors. Pellet density response surfaces and durability index were obtained. Pellet performance during thermal-chemical transformation was also evaluated by using thermogravimetry equipment. The results led to technical evaluation of scale-up at industrial production level.

  3. Agent-Based Urban Land Markets: Agent's Pricing Behavior, Land Prices and Urban Land Use Change

    NARCIS (Netherlands)

    Filatova, Tatiana; Parker, Dawn; Veen, van der Anne

    2009-01-01

    We present a new bilateral agent-based land market model, which moves beyond previous work by explicitly modeling behavioral drivers of land-market transactions on both the buyer and seller sides; formation of bid prices (of buyers) and ask prices (of sellers); and the relative division of the gains

  4. The Development of Sugar-Based Anti-Melanogenic Agents.

    Science.gov (United States)

    Bin, Bum-Ho; Kim, Sung Tae; Bhin, Jinhyuk; Lee, Tae Ryong; Cho, Eun-Gyung

    2016-01-01

    The regulation of melanin production is important for managing skin darkness and hyperpigmentary disorders. Numerous anti-melanogenic agents that target tyrosinase activity/stability, melanosome maturation/transfer, or melanogenesis-related signaling pathways have been developed. As a rate-limiting enzyme in melanogenesis, tyrosinase has been the most attractive target, but tyrosinase-targeted treatments still pose serious potential risks, indicating the necessity of developing lower-risk anti-melanogenic agents. Sugars are ubiquitous natural compounds found in humans and other organisms. Here, we review the recent advances in research on the roles of sugars and sugar-related agents in melanogenesis and in the development of sugar-based anti-melanogenic agents. The proposed mechanisms of action of these agents include: (a) (natural sugars) disturbing proper melanosome maturation by inducing osmotic stress and inhibiting the PI3 kinase pathway and (b) (sugar derivatives) inhibiting tyrosinase maturation by blocking N-glycosylation. Finally, we propose an alternative strategy for developing anti-melanogenic sugars that theoretically reduce melanosomal pH by inhibiting a sucrose transporter and reduce tyrosinase activity by inhibiting copper incorporation into an active site. These studies provide evidence of the utility of sugar-based anti-melanogenic agents in managing skin darkness and curing pigmentary disorders and suggest a future direction for the development of physiologically favorable anti-melanogenic agents. PMID:27092497

  5. Agent-based services for B2B electronic commerce

    Science.gov (United States)

    Fong, Elizabeth; Ivezic, Nenad; Rhodes, Tom; Peng, Yun

    2000-12-01

    The potential of agent-based systems has not been realized yet, in part, because of the lack of understanding of how the agent technology supports industrial needs and emerging standards. The area of business-to-business electronic commerce (b2b e-commerce) is one of the most rapidly developing sectors of industry with huge impact on manufacturing practices. In this paper, we investigate the current state of agent technology and the feasibility of applying agent-based computing to b2b e-commerce in the circuit board manufacturing sector. We identify critical tasks and opportunities in the b2b e-commerce area where agent-based services can best be deployed. We describe an implemented agent-based prototype system to facilitate the bidding process for printed circuit board manufacturing and assembly. These activities are taking place within the Internet Commerce for Manufacturing (ICM) project, the NIST- sponsored project working with industry to create an environment where small manufacturers of mechanical and electronic components may participate competitively in virtual enterprises that manufacture printed circuit assemblies.

  6. Reliability of Service-Based and Agent-Based Systems

    OpenAIRE

    Huhns, Michael N.

    2010-01-01

    A description of the current problems of service-oriented architectures and service-oriented computing and how the solutions will come from using agent technology. That is, services will have to become more agent-like in order to succeed fully in the marketplace.

  7. Fuzzy Motivations in a Multiple Agent Behaviour-Based Architecture

    Directory of Open Access Journals (Sweden)

    Tomás V. Arredondo

    2013-08-01

    Full Text Available In this article we introduce a blackboard- based multiple agent system framework that considers biologically-based motivations as a means to develop a user friendly interface. The framework includes a population-based heuristic as well as a fuzzy logic- based inference system used toward scoring system behaviours. The heuristic provides an optimization environment and the fuzzy scoring mechanism is used to give a fitness score to possible system outputs (i.e. solutions. This framework results in the generation of complex behaviours which respond to previously specified motivations. Our multiple agent blackboard and motivation-based framework is validated in a low cost mobile robot specifically built for this task. The robot was used in several navigation experiments and the motivation profile that was considered included "curiosity", "homing", "energy" and "missions". Our results show that this motivation-based approach permits a low cost multiple agent-based autonomous mobile robot to acquire a diverse set of fit behaviours that respond well to user and performance expectations. These results also validate our multiple agent framework as an incremental, flexible and practical method for the development of robust multiple agent systems.

  8. QoS Negotiation and Renegotiation Based on Mobile Agents

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-bing; ZHANG Deng-yin

    2006-01-01

    The Quality of Service (QoS) has received more and more attention since QoS becomes increasingly important in the Internet development. Mobile software agents represent a valid alternative to the implementation of strategies for the negotiation. In this paper, a QoS negotiation and renegotiation system architecture based on mobile agents is proposed. The agents perform the task in the whole process. Therefore, such a system can reduce the network load, overcome latency, and avoid frequent exchange information between clients and server. The simulation results show that the proposed system could improve the network resource utility about 10%.

  9. Emergent Macroeconomics An Agent-Based Approach to Business Fluctuations

    CERN Document Server

    Delli Gatti, Domenico; Gallegati, Mauro; Giulioni, Gianfranco; Palestrini, Antonio

    2008-01-01

    This book contributes substantively to the current state-of-the-art of macroeconomics by providing a method for building models in which business cycles and economic growth emerge from the interactions of a large number of heterogeneous agents. Drawing from recent advances in agent-based computational modeling, the authors show how insights from dispersed fields like the microeconomics of capital market imperfections, industrial dynamics and the theory of stochastic processes can be fruitfully combined to improve our understanding of macroeconomic dynamics. This book should be a valuable resource for all researchers interested in analyzing macroeconomic issues without recurring to a fictitious representative agent.

  10. Agent-based computational economics using NetLogo

    CERN Document Server

    Damaceanu, Romulus-Catalin

    2013-01-01

    Agent-based Computational Economics using NetLogo explores how researchers can create, use and implement multi-agent computational models in Economics by using NetLogo software platform. Problems of economic science can be solved using multi-agent modelling (MAM). This technique uses a computer model to simulate the actions and interactions of autonomous entities in a network, in order to analyze the effects on the entire economic system. MAM combines elements of game theory, complex systems, emergence and evolutionary programming. The Monte Carlo method is also used in this e-book to introduc

  11. Tutorial on agent-based modeling and simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Macal, C. M.; North, M. J.; Decision and Information Sciences

    2005-01-01

    Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of autonomous, interacting agents. ABMS promises to have far-reaching effects on the way that businesses use computers to support decision-making and researchers use electronic laboratories to support their research. Some have gone so far as to contend that ABMS is a third way of doing science besides deductive and inductive reasoning. Computational advances have made possible a growing number of agent-based applications in a variety of fields. Applications range from modeling agent behavior in the stock market and supply chains, to predicting the spread of epidemics and the threat of bio-warfare, from modeling consumer behavior to understanding the fall of ancient civilizations, to name a few. This tutorial describes the theoretical and practical foundations of ABMS, identifies toolkits and methods for developing ABMS models, and provides some thoughts on the relationship between ABMS and traditional modeling techniques.

  12. A Multiagent Recommender System with Task-Based Agent Specialization

    Science.gov (United States)

    Lorenzi, Fabiana; Correa, Fabio Arreguy Camargo; Bazzan, Ana L. C.; Abel, Mara; Ricci, Francesco

    This paper describes a multiagent recommender system where agents maintain local knowledge bases and, when requested to support a travel planning task, they collaborate exchanging information stored in their local bases. A request for a travel recommendation is decomposed by the system into sub tasks, corresponding to travel services. Agents select tasks autonomously, and accomplish them with the help of the knowledge derived from previous solutions. In the proposed architecture, agents become experts in some task types, and this makes the recommendation generation more efficient. In this paper, we validate the model via simulations where agents collaborate to recommend a travel package to the user. The experiments show that specialization is useful hence providing a validation of the proposed model.

  13. An Agent-Based Modeling for Pandemic Influenza in Egypt

    CERN Document Server

    Khalil, Khaled M; Nazmy, Taymour T; Salem, Abdel-Badeeh M

    2010-01-01

    Pandemic influenza has great potential to cause large and rapid increases in deaths and serious illness. The objective of this paper is to develop an agent-based model to simulate the spread of pandemic influenza (novel H1N1) in Egypt. The proposed multi-agent model is based on the modeling of individuals' interactions in a space time context. The proposed model involves different types of parameters such as: social agent attributes, distribution of Egypt population, and patterns of agents' interactions. Analysis of modeling results leads to understanding the characteristics of the modeled pandemic, transmission patterns, and the conditions under which an outbreak might occur. In addition, the proposed model is used to measure the effectiveness of different control strategies to intervene the pandemic spread.

  14. Next frontier in agent-based complex automated negotiation

    CERN Document Server

    Ito, Takayuki; Zhang, Minjie; Robu, Valentin

    2015-01-01

    This book focuses on automated negotiations based on multi-agent systems. It is intended for researchers and students in various fields involving autonomous agents and multi-agent systems, such as e-commerce tools, decision-making and negotiation support systems, and collaboration tools. The contents will help them to understand the concept of automated negotiations, negotiation protocols, negotiating agents’ strategies, and the applications of those strategies. In this book, some negotiation protocols focusing on the multiple interdependent issues in negotiations are presented, making it possible to find high-quality solutions for the complex agents’ utility functions. This book is a compilation of the extended versions of the very best papers selected from the many that were presented at the International Workshop on Agent-Based Complex Automated Negotiations.

  15. Enteral composition for investigation of alimentary function with radio-tracer, binding agent and excipient in multiple units

    International Nuclear Information System (INIS)

    Enterally administrable diagnostic composition for the investigation of alimentary functions comprises multiple units each of up to 5 mm in size. Each unit comprises a tracer binding agent associated with a radioactive tracer of half-life up to 5 days. The binding agent is formulated with at least one excipient in such a way that when the composition is administered, exposure of the gastrointestinal mucosa to the tracer-binding agent is reduced. The units do not disintegrate during passage through the gastrointestinal tract. With the composition the risk of long-term radiation injury is reduced for the patient and for the staff involved int he clinical investigation. Many binders that are not proven as non-toxic may be used. Local irritation of the gastrointestinal mucosa can be greatly reduced by appropiate selection of tracer, binder and excipient. A dosage contains at least 50 units and they distribute in the gastrointestinal in a reproducible statistical way. In contrast to BaSO4 meals, the compositions can be formulated so that they do not coat or adhere to the mucous membrane in the alimentary canal. The compositions can be easily made as required from kits. They are useful in the diagnosis etc. of a wide range of diseases. The monitoring of food-stimulating units through the alimentary canal is possible, and the determination of many variable factors can be made. (au)

  16. Applications of Neural-Based Agents in Computer Game Design

    OpenAIRE

    Qualls, Joseph; Russomanno, David J.

    2009-01-01

    It is clear from the implementation and analysis of the performance of the game Defend and Gather and the many other examples discussed in this chapter that neural-based agents have the ability to overcome some of the shortcomings associated with implementing classical AI techniques in computer game design. Neural networks can be used in many diverse ways in computer games ranging from agent control, environmental evolution, to content generation. As outlined in Section 3 of this chapter, by ...

  17. Design of distance teaching platform based on Agent technology

    Institute of Scientific and Technical Information of China (English)

    LI Xiaoming; SUN Hongmin; WU Wansheng

    2007-01-01

    The computer network technology and multi-media technology offer a new teaching mode for the distance education. Now there are still many problems in modern distance education such as weak generality, flexibility and intelligence, etc. This paper brought up a design mode of distance teaching platform based on Agent mechanism and the concrete implementation method through analyzing the characteristic and structure of Agent technology.

  18. Agent-based Model Construction in Financial Economic System

    OpenAIRE

    Hokky Situngkir; Yohanes Surya

    2004-01-01

    The paper gives picture of enrichment to economic and financial system analysis using agent-based models as a form of advanced study for financial economic data post-statistical-data analysis and micro- simulation analysis. Theoretical exploration is carried out by using comparisons of some usual financial economy system models frequently and popularly used in econophysics and computational finance. Primitive model, which consists of agent microsimulation with fundamentalist strategy, chartis...

  19. Agent-based decision making through intelligent knowledge discovery

    OpenAIRE

    Fernández Caballero, Antonio; Sokolova, Marina

    2008-01-01

    Monitoring of negative effects of urban pollution and real-time decision making allow to clarify consequences upon human health. Large amounts of raw data information describe this situation, and to get knowledge from it, we apply intelligent agents. Further modeling and simulation gives the new knowledge about the tendencies of situation development and about its structure. Agent-based decision support system can help to foresee possible ways of situation development and contribute to effect...

  20. A cooperative agent-based security framework

    OpenAIRE

    Cunha, Carlos R.; Gomes, João Pedro; Morais, Elisabete Paulo

    2013-01-01

    The actual economic paradigm is based on a strongly cooperative model that tries to support a more competitive and global organizations response. With cooperation comes an intrinsic need - interconnection and interoperability of information systems among business partners. This represents, in many areas, a huge organizational challenge, being the field of information, and communication security one emerging key issue and a natural enabler for cooperative behavior and to the proper establishme...

  1. Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

    Science.gov (United States)

    Murahashi, Masataka; Simizu, Siro; Morioka, Masahiko; Umezawa, Kazuo

    2016-08-01

    15-Deoxyspergualin (DSG) is an immunosuppressive agent being clinically used. Unlike tacrolimus and cyclosporine A, it does not inhibit the calcineurin pathway, and its mechanism of action and target molecule have not been elucidated. Therefore, we previously prepared biotinylated derivative of DSG (BDSG) to fish up the target protein. In the present research, we identified poly(rC) binding protein 2 (PCBP2) as a DSG-binding protein using this probe. DSG was confirmed to bind to PCBP2 by pull-down assay. Intracellular localization of PCBP2 was changed from the nucleus to the cytoplasm by DSG treatment. DSG inhibited the cell growth, and over-expression of PCBP2 reduced the anti-proliferative activity of DSG. PCBP2 is known to regulate various proteins including STAT1/2. Thus, we found PCBP2 as the first target protein of DSG that can explain the immunosuppressive activity. PMID:27261432

  2. Agent-based modeling and simulation Part 3 : desktop ABMS.

    Energy Technology Data Exchange (ETDEWEB)

    Macal, C. M.; North, M. J.; Decision and Information Sciences

    2007-01-01

    Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of autonomous, interacting agents. ABMS promises to have far-reaching effects on the way that businesses use computers to support decision-making and researchers use electronic laboratories to support their research. Some have gone so far as to contend that ABMS 'is a third way of doing science,' in addition to traditional deductive and inductive reasoning (Axelrod 1997b). Computational advances have made possible a growing number of agent-based models across a variety of application domains. Applications range from modeling agent behavior in the stock market, supply chains, and consumer markets, to predicting the spread of epidemics, the threat of bio-warfare, and the factors responsible for the fall of ancient civilizations. This tutorial describes the theoretical and practical foundations of ABMS, identifies toolkits and methods for developing agent models, and illustrates the development of a simple agent-based model of shopper behavior using spreadsheets.

  3. Reflection-Based Python-C++ Bindings

    International Nuclear Information System (INIS)

    Python is a flexible, powerful, high-level language with excellent interactive and introspective capabilities and a very clean syntax. As such, it can be a very effective tool for driving physics analysis. Python is designed to be extensible in low-level C-like languages, and its use as a scientific steering language has become quite widespread. To this end, existing and custom-written C or C++ libraries are bound to the Python environment as so-called extension modules. A number of tools for easing the process of creating such bindings exist, such as SWIG and Boost. Python. Yet, the process still requires a considerable amount of effort and expertise. The C++ language has few built-in introspective capabilities, but tools such as LCGDict and CINT add this by providing so-called dictionaries: libraries that contain information about the names, entry points, argument types, etc. of other libraries. The reflection information from these dictionaries can be used for the creation of bindings and so the process can be fully automated, as dictionaries are already provided for many end-user libraries for other purposes, such as object persistency. PyLCGDict is a Python extension module that uses LCG dictionaries, as PyROOT uses CINT reflection information, to allow /cwPython users to access C++ libraries with essentially no preparation on the users' behalf. In addition, and in a similar way, PyROOT gives ROOT users access to Python libraries

  4. Agent-Based Simulations for Project Management

    Science.gov (United States)

    White, J. Chris; Sholtes, Robert M.

    2011-01-01

    Currently, the most common approach used in project planning tools is the Critical Path Method (CPM). While this method was a great improvement over the basic Gantt chart technique being used at the time, it now suffers from three primary flaws: (1) task duration is an input, (2) productivity impacts are not considered , and (3) management corrective actions are not included. Today, computers have exceptional computational power to handle complex simulations of task e)(eculion and project management activities (e.g ., dynamically changing the number of resources assigned to a task when it is behind schedule). Through research under a Department of Defense contract, the author and the ViaSim team have developed a project simulation tool that enables more realistic cost and schedule estimates by using a resource-based model that literally turns the current duration-based CPM approach "on its head." The approach represents a fundamental paradigm shift in estimating projects, managing schedules, and reducing risk through innovative predictive techniques.

  5. An Immunity-Based Anomaly Detection System with Sensor Agents

    Directory of Open Access Journals (Sweden)

    Yoshiteru Ishida

    2009-11-01

    Full Text Available This paper proposes an immunity-based anomaly detection system with sensor agents based on the specificity and diversity of the immune system. Each agent is specialized to react to the behavior of a specific user. Multiple diverse agents decide whether the behavior is normal or abnormal. Conventional systems have used only a single sensor to detect anomalies, while the immunity-based system makes use of multiple sensors, which leads to improvements in detection accuracy. In addition, we propose an evaluation framework for the anomaly detection system, which is capable of evaluating the differences in detection accuracy between internal and external anomalies. This paper focuses on anomaly detection in user’s command sequences on UNIX-like systems. In experiments, the immunity-based system outperformed some of the best conventional systems.

  6. A distributed agent-based architecture for dynamic services

    International Nuclear Information System (INIS)

    A prototype system for agent-based distributed dynamic services that will be applied to the development of Data Grids for high-energy physics is presented. The agent-based systems we are designing and developing gather, disseminate and coordinate configuration, time-dependent state and other information in the Grid system as a whole. These systems are being developed as an enabling technology for workflow-management and other forms of end-to-end Grid system monitoring and management. This prototype is being developed in Java and is based on the JINI support for distributed applications

  7. Analyzing the ENRON Communication Network Using Agent-Based Simulation

    Directory of Open Access Journals (Sweden)

    Shinako Matsuyama

    2008-07-01

    Full Text Available Agent-based modeling, simulation, and network analysis approaches are one of the emergent techniques among soft computing literature. This paper presents an agent-based model for analyzing the characteristics of peer-to-peer human communication networks. We focus on the process of the collapse of Enron Corporation, which is an interesting topic among the business management domain. The Enron email dataset is available for the analysis. Our approach consists of the four steps: First, macro-level characteristics of the Enron email dataset is analyzed from the viewpoints of social network theory: (i the degrees of the communication networks and contents information, and (ii the changes of network structures among the major events. Second, for the micro-level analysis, an agent-based simulator is implemented using the Enron email dataset. Third, both micro- and macro- level characteristics are calculated on the simulator to ground the model to the dataset. Finally, a different artificial society from the Enron email dataset is developed the simulator and we compare its characteristics of communication patterns with the result of the ones in the agent-based simulation with the Enron email dataset. The investigation suggests that the agent-based model is beneficial to uncover the characteristics of implicit communication mechanisms of the firm.

  8. Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltration technique for the determination of plasma protein binding of three coumarins using acetone as protein binding releasing agent.

    Science.gov (United States)

    Li, Junmei; Shi, Qingwen; Jiang, Ye; Liu, Yan

    2015-09-15

    A novel and practical sample pretreatment method based on hollow fiber centrifugal ultrafiltration (HFCF-UF) was developed to determine plasma protein binding by using HPLC. The samples for analyzing unbound and total concentrations could be prepared in parallel simultaneously by the same device. It only required centrifugation for a short time and the filtrate could be injected directly for HPLC analysis without further treatment. Coumarins were selected as the model drugs. Acetone was chosen as the releasing agent to free the binding drug from the drug-protein complex for the total drug concentration determination. Non-specific bindings (NSBs) between the analytes and hollow fiber membrane materials were investigated. The type and volume of protein binding releaser were optimized. Additionally, centrifugal speed and centrifugal time were considered. Under the optimized conditions, the absolute recovery rates of the unbound and total concentrations were in the range of 97.5-100.9% for the three analytes. The limits of detection were in the range of 0.0135-0.0667μgmL(-1). In vitro plasma protein binding of the three coumarins was determined at three concentrations using the validated method and the relative standard deviations (RSDs) were less than 3.4%. Compared with traditional method, the HFCF-UF method is simple to run, no specialized equipment requirement and is a more accurate plasma pretreatment procedure with almost excellent drug-protein binding equilibrium. Therefore, this method can be applied to determine the plasma protein binding in clinical practice. It also provides a reliable alternative for accurate monitoring of unbound or total drug concentration in therapeutic drug monitoring (TDM). PMID:26276065

  9. Nanochemistry of Protein-Based Delivery Agents.

    Science.gov (United States)

    Rajendran, Subin R C K; Udenigwe, Chibuike C; Yada, Rickey Y

    2016-01-01

    The past decade has seen an increased interest in the conversion of food proteins into functional biomaterials, including their use for loading and delivery of physiologically active compounds such as nutraceuticals and pharmaceuticals. Proteins possess a competitive advantage over other platforms for the development of nanodelivery systems since they are biocompatible, amphipathic, and widely available. Proteins also have unique molecular structures and diverse functional groups that can be selectively modified to alter encapsulation and release properties. A number of physical and chemical methods have been used for preparing protein nanoformulations, each based on different underlying protein chemistry. This review focuses on the chemistry of the reorganization and/or modification of proteins into functional nanostructures for delivery, from the perspective of their preparation, functionality, stability and physiological behavior. PMID:27489854

  10. Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents.

    Directory of Open Access Journals (Sweden)

    Naresh Kumar Manchukonda

    Full Text Available Systematic screening based on structural similarity of drugs such as colchicine and podophyllotoxin led to identification of noscapine, a microtubule-targeted agent that attenuates the dynamic instability of microtubules without affecting the total polymer mass of microtubules. We report a new generation of noscapine derivatives as potential tubulin binding anti-cancer agents. Molecular modeling experiments of these derivatives 5a, 6a-j yielded better docking score (-7.252 to -5.402 kCal/mol than the parent compound, noscapine (-5.505 kCal/mol and its existing derivatives (-5.563 to -6.412 kCal/mol. Free energy (ΔG bind calculations based on the linear interaction energy (LIE empirical equation utilizing Surface Generalized Born (SGB continuum solvent model predicted the tubulin-binding affinities for the derivatives 5a, 6a-j (ranging from -4.923 to -6.189 kCal/mol. Compound 6f showed highest binding affinity to tubulin (-6.189 kCal/mol. The experimental evaluation of these compounds corroborated with theoretical studies. N-(3-brormobenzyl noscapine (6f binds tubulin with highest binding affinity (KD, 38 ± 4.0 µM, which is ~ 4.0 times higher than that of the parent compound, noscapine (KD, 144 ± 1.0 µM and is also more potent than that of the first generation clinical candidate EM011, 9-bromonoscapine (KD, 54 ± 9.1 µM. All these compounds exhibited substantial cytotoxicity toward cancer cells, with IC50 values ranging from 6.7 µM to 72.9 µM; compound 6f showed prominent anti-cancer efficacy with IC50 values ranging from 6.7 µM to 26.9 µM in cancer cells of different tissues of origin. These compounds perturbed DNA synthesis, delayed the cell cycle progression at G2/M phase, and induced apoptotic cell death in cancer cells. Collectively, the study reported here identified potent, third generation noscapinoids as new anti-cancer agents.

  11. Agent-based modelling of socio-technical systems

    CERN Document Server

    van Dam, Koen H; Lukszo, Zofia

    2012-01-01

    Here is a practical introduction to agent-based modelling of socio-technical systems, based on methodology developed at TU Delft, which has been deployed in a number of case studies. Offers theory, methods and practical steps for creating real-world models.

  12. Agent-based analysis of organizations : formalization and simulation

    OpenAIRE

    Dignum, M.V.; Tick, C.

    2008-01-01

    Organizational effectiveness depends on many factors, including individual excellence, efficient structures, effective planning and capability to understand and match context requirements. We propose a way to model organizational performance based on a combination of formal models and agent-based simulation that supports the analysis of the congruence of different organizational structures to changing environments

  13. An Agent Communication Framework Based on XML and SOAP Technique

    Institute of Scientific and Technical Information of China (English)

    李晓瑜

    2009-01-01

    This thesis introducing XML technology and SOAP technology,present an agent communication fi-amework based on XML and SOAP technique,and analyze the principle,architecture,function and benefit of it. At the end, based on KQML communication primitive lan- guages.

  14. A role based coordination model in agent systems

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ya-ying; YOU Jin-yuan

    2005-01-01

    Coordination technology addresses the construction of open, flexible systems from active and independent software agents in concurrent and distributed systems. In most open distributed applications, multiple agents need interaction and communication to achieve their overall goal. Coordination technologies for the Internet typically are concerned with enabling interaction among agents and helping them cooperate with each other.At the same time, access control should also be considered to constrain interaction to make it harmless. Access control should be regarded as the security counterpart of coordination. At present, the combination of coordination and access control remains an open problem. Thus, we propose a role based coordination model with policy enforcement in agent application systems. In this model, coordination is combined with access control so as to fully characterize the interactions in agent systems. A set of agents interacting with each other for a common global system task constitutes a coordination group. Role based access control is applied in this model to prevent unauthorized accesses. Coordination policy is enforced in a distributed manner so that the model can be applied to the open distributed systems such as Intemet. An Internet online auction system is presented as a case study to illustrate the proposed coordination model and finally the performance analysis of the model is introduced.

  15. Study on the agile supply chain management based on agent

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The most important task of the agile supply chain management (ASCM) is to reconfigure a supply chain based on the customers' requirement. Without more sophisticated cooperation and dynamic formation in an agile supply chain, it cannot be achieved for mass customization, rapid response and high quality services. Because of its great potential in supporting cooperation for the supply chain management, agent technology can carry out the cooperative work by inter-operation across networked human, organization and machines at the abstractive level in a computational system. A major challenge in building such a system is to coordinate the behavior of individual agent or a group of agents to achieve the individual and shared goals of the participants. In this paper, the agent technology is used to support modeling and coordinating of supply chain management.

  16. Web Crawler Based on Mobile Agent and Java Aglets

    Directory of Open Access Journals (Sweden)

    Md. Abu Kausar

    2013-09-01

    Full Text Available With the huge growth of the Internet, many web pages are available online. Search engines use web crawlers to collect these web pages from World Wide Web for the purpose of storage and indexing. Basically Web Crawler is a program, which finds information from the World Wide Web in a systematic and automated manner. This network load farther will be reduced by using mobile agents.The proposed approach uses mobile agents to crawl the pages. A mobile agent is not bound to the system in which it starts execution. It has the unique ability to transfer itself from one system in a network to another system. The main advantages of web crawler based on Mobile Agents are that the analysis part of the crawling process is done locally rather than remote side. This drastically reduces network load and traffic which can improve the performance and efficiency of the whole crawling process.

  17. The architectural foundations for agent-based shop floor control

    DEFF Research Database (Denmark)

    Langer, Gilad; Bilberg, Arne

    1998-01-01

    The emerging theory regardingHolonic Manufacturing Systems (HMS) presents a advantageoustheoretical foundation for the control system of themanufacturing system of the future. Previous research, at theDepartment, has demonstrated how company tailored shop floorcontrol can be developed by applying...... the HoMuCS architecture can berealised by using multi-agent technology,and that it is also therequired foundation for implementation of agent technology inmanufacturing system control. The work is based on a theoreticalstudy of new manufacturing system theories, research of agent and multi...... simulation and cell controlenabling technologies. In order to continuethis research effortnew concepts and theories for shop floor control are investigated.This paper reviews the multi-agent concept aimed at investigatingits potential use in shop floor control systems. The paper willalso include a survey of...

  18. AGENT based structural static and dynamic collaborative optimization

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A static and dynamic collaborative optimization mode for complex machine system and itsontology project relationship are put forward, on which an agent-based structural static and dynamiccollaborative optimization system is constructed as two agent colonies: optimization agent colony andfinite element analysis colony. And a two-level solving strategy as well as the necessity and possibilityfor handing with finite element analysis model in multi-level mode is discussed. Furthermore, the coop-eration of all FEA agents for optimal design of complicated structural is studied in detail. Structural stat-ic and dynamic collaborative optimization of hydraulic excavator working equimpent is taken as an ex-ample to show that the system is reliable.

  19. Agent-based simulation of electricity markets : a literature review

    International Nuclear Information System (INIS)

    The electricity sector in Europe and North America is undergoing considerable changes as a result of deregulation, issues related to climate change, and the integration of renewable resources within the electricity grid. This article reviewed agent-based simulation methods of analyzing electricity markets. The paper provided an analysis of research currently being conducted on electricity market designs and examined methods of modelling agent decisions. Methods of coupling long term and short term decisions were also reviewed. Issues related to single and multiple market analysis methods were discussed, as well as different approaches to integrating agent-based models with models of other commodities. The integration of transmission constraints within agent-based models was also discussed, and methods of measuring market efficiency were evaluated. Other topics examined in the paper included approaches to integrating investment decisions, carbon dioxide (CO2) trading, and renewable support schemes. It was concluded that agent-based models serve as a test bed for the electricity sector, and will help to provide insights for future policy decisions. 74 refs., 6 figs

  20. Macromolecular and dendrimer-based magnetic resonance contrast agents

    International Nuclear Information System (INIS)

    Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed

  1. Macromolecular and dendrimer-based magnetic resonance contrast agents

    Energy Technology Data Exchange (ETDEWEB)

    Bumb, Ambika; Brechbiel, Martin W. (Radiation Oncology Branch, National Cancer Inst., National Inst. of Health, Bethesda, MD (United States)), e-mail: pchoyke@mail.nih.gov; Choyke, Peter (Molecular Imaging Program, National Cancer Inst., National Inst. of Health, Bethesda, MD (United States))

    2010-09-15

    Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed

  2. Timing and modality of the sclerosing agents binding to the human proteins: laboratory analysis and clinical evidences

    Directory of Open Access Journals (Sweden)

    Lorenzo Tessari

    2014-07-01

    Full Text Available Sclerosing agents (SA are blood inactivated. Nevertheless, investigations concerning the interaction among SA and blood components have never been deeply investigated. Aim of the study is to precisely identify SA blood ligands, to determine their binding time and to highlight the clinical consequences. Thirty-one blood samples were collected from chronic venous disease patients and tested by capillary and agarose gel (AGE electrophoresis before and after adding polidocanol (POL and sodiumtetradecylsulphate (STS. The two different types of electrophoresis allowed an evaluation of the blood proteins binding with the sclerosing agents, with a reaction time lower than 8 seconds for the AGE. Subsequently six patients underwent foam sclerotherapy and then were subdivided in group A (4 patients and B (2 patients. In group A blood sample was obtained from the ipsilateral brachial vein immediately before (T0 and repeated 1, 3, 5, and 10 minutes after injection of STS 3% injection into the GSV. In group B, the same procedure was performed with the same timing from the ipsilateral femoral vein. Free STS (fSTS and total proteinbound STS (bSTS were measured. POL mainly binds to β-globulins (11%, while STS to albumin and α-globulins (62.6% and 30.7% on the protidogram, respectively. Both in the brachial and in the femoral vein, the average fSTS was always 0. STS binds to albumin (62.6% and α-globulins (30.7%, while POL is bound mainly by the b-globulins (11%. The present paper demonstrates how the vast majority of the sclerosing agent is bound to the blood proteins, suggesting the need to look for possible sclerotherapy complications factors also in the used gas and/or in the subsequent cathabolites release.

  3. Mass Spectrometry-Based Monitoring of Millisecond Protein-Ligand Binding Dynamics Using an Automated Microfluidic Platform

    Energy Technology Data Exchange (ETDEWEB)

    Cong, Yongzheng; Katipamula, Shanta; Trader, Cameron D.; Orton, Daniel J.; Geng, Tao; Baker, Erin Shammel; Kelly, Ryan T.

    2016-03-24

    Characterizing protein-ligand binding dynamics is crucial for understanding protein function and developing new therapeutic agents. We have developed a novel microfluidic platform that features rapid mixing of protein and ligand solutions, variable incubation times, and on-chip electrospray ionization to perform label-free, solution-based monitoring of protein-ligand binding dynamics. This platform offers many advantages including automated processing, rapid mixing, and low sample consumption.

  4. Smart Agent Learning based Hotel Search System- Android Environment

    Directory of Open Access Journals (Sweden)

    Wayne Lawrence

    2012-08-01

    Full Text Available The process of finding the finest hotel in central location is time consuming, information overload and overwhelming and in some cases poses a security risk to the client. Over time with competition in the market among travel agents and hotels, the process of hotel search and booking has improved with the advances in technology. Various web sites allow a user to select a destination from a pull-down list along with several categories to suit one’s preference.. Some of the more advanced web sites allow for a search of the destination via a map for example hotelguidge.com and jamaica.hotels.hu. Recently good amount of work been carried in the use of Intelligent agents towards hotel search on J2ME based mobile handset which still has some weakness. The proposed system so developed uses smart software agents that overcomes the weakness in the previous system by collaborating among themselves and search Google map based on criteria selected by the user and return results to the client that is precise and best suit the user requirements. In addition, the agent possesses learning capability of searching the hotels too which is based on past search experience. The booking of hotel involving cryptography has not been incorporated in this research paper and been published elsewhere. This will be facilitated on Android 2.2-enabled mobile phone using JADE-LEAP Agent development kit.

  5. Agent-Based Urban Land Markets: Agent's Pricing Behavior, Land Prices and Urban Land Use Change

    OpenAIRE

    Filatova, Tatiana; Parker, Dawn; Veen, van der, J.T.

    2009-01-01

    We present a new bilateral agent-based land market model, which moves beyond previous work by explicitly modeling behavioral drivers of land-market transactions on both the buyer and seller sides; formation of bid prices (of buyers) and ask prices (of sellers); and the relative division of the gains from trade from the market transactions. We analyze model output using a series of macro-scale economic and landscape pattern measures, including land rent gradients estimated using simple regress...

  6. TOWARDS AN ONTOLOGY-BASED MULTI-AGENT MEDICAL INFORMATION SYSTEM BASED ON THE WEB

    Institute of Scientific and Technical Information of China (English)

    张全海; 施鹏飞

    2002-01-01

    This paper described an ontology-based multi-agent knowledge process made (MAKM) which is one of multi-agents systems (MAS) and uses semantic network to describe agents to help to locate relative agents distributed in the workgroup. In MAKM, an agent is the entity to implement the distributed task processing and to access the information or knowledge. Knowledge query manipulation language (KQML) is adapted to realize the communication among agents. So using the MAKM mode, different knowledge and information on the medical domain could be organized and utilized efficiently when a collaborative task is implemented on the web.

  7. Towards Designing Multi Agent Mobile and Internet Based Voting System

    Directory of Open Access Journals (Sweden)

    Mohamed Khlaif

    2013-04-01

    Full Text Available Voting systems are essential in most democratic societies .Thevoting process is very difficult and consuming time and effortprocess. One of the major problems of voting is the securityprocess. The E-voting system is process to use mobile multiagents system which can be less time consuming and moreaccurate due to Agent role through encryption/decryption whichreduce the risk of casting vote In trouble environment. the votewill be received by the agent which will be encrypted and sent tomobile data base, and similar action is carried out in the Internetagent who will carry out similar process in a similar manner .Voting data is collected in three different sources whicheventually collected in master data base after decrypting all votes. the counting agent counts the votes and classify votes for eachperspective owner.

  8. Return Migration After Brain Drain: An Agent Based Simulation Approach

    CERN Document Server

    Biondo, A E; Rapisarda, A

    2012-01-01

    The Brain Drain phenomenon is particularly heterogeneous and is characterized by peculiar specifications. It influences the economic fundamentals of both the country of origin and the host one in terms of human capital accumulation. Here, the brain drain is considered from a microeconomic perspective: more precisely we focus on the individual rational decision to return, referring it to the social capital owned by the worker. The presented model, restricted to the case of academic personnel, compares utility levels to justify agent's migration conduct and to simulate several scenarios with a NetLogo agent based model. In particular, we developed a simulation framework based on two fundamental individual features, i.e. risk aversion and initial expectation, which characterize the dynamics of different agents according to the random evolution of their personal social networks. Our main result is that, according to the value of risk aversion and initial expectation, the probability of return migration depends on...

  9. Agent-based Modeling with MATSim for Hazards Evacuation Planning

    Science.gov (United States)

    Jones, J. M.; Ng, P.; Henry, K.; Peters, J.; Wood, N. J.

    2015-12-01

    Hazard evacuation planning requires robust modeling tools and techniques, such as least cost distance or agent-based modeling, to gain an understanding of a community's potential to reach safety before event (e.g. tsunami) arrival. Least cost distance modeling provides a static view of the evacuation landscape with an estimate of travel times to safety from each location in the hazard space. With this information, practitioners can assess a community's overall ability for timely evacuation. More information may be needed if evacuee congestion creates bottlenecks in the flow patterns. Dynamic movement patterns are best explored with agent-based models that simulate movement of and interaction between individual agents as evacuees through the hazard space, reacting to potential congestion areas along the evacuation route. The multi-agent transport simulation model MATSim is an agent-based modeling framework that can be applied to hazard evacuation planning. Developed jointly by universities in Switzerland and Germany, MATSim is open-source software written in Java and freely available for modification or enhancement. We successfully used MATSim to illustrate tsunami evacuation challenges in two island communities in California, USA, that are impacted by limited escape routes. However, working with MATSim's data preparation, simulation, and visualization modules in an integrated development environment requires a significant investment of time to develop the software expertise to link the modules and run a simulation. To facilitate our evacuation research, we packaged the MATSim modules into a single application tailored to the needs of the hazards community. By exposing the modeling parameters of interest to researchers in an intuitive user interface and hiding the software complexities, we bring agent-based modeling closer to practitioners and provide access to the powerful visual and analytic information that this modeling can provide.

  10. Role Oriented Test Case Generation for Agent Based System

    Directory of Open Access Journals (Sweden)

    N.Sivakumar

    2013-02-01

    Full Text Available Agent Oriented Software Engineering (AOSE is a rapidly developing area of research. Current research and development primarily focuses on the analysis, design and implementation of agent based software whereas testing is less prioritised. Software testing is an important and indispensable part of software development process. Test case generation is the primary step of any testing process which is followed by test execution and test evaluation. Test case generation is not an easy task but upon automating the test case generation process serves many advantages such as time saving, effort saving and more importantly reduces number of errors and faults. This paper investigates about generating test cases for testing agent based software. We propose a novel approach, which takes advantage of agent’s role as the basis for generating test cases. Role is an important mental attribute of an agent which is simply defined as the set of capabilities that an agent can perform. The main objective of this paper is to generate test cases from role diagram upon converting it to activity diagram.

  11. Engineering Agent-Based Social Simulations: An Introduction

    OpenAIRE

    Peer-Olaf Siebers; Paul Davidsson

    2015-01-01

    This special section on "Engineering Agent-Based Social Simulations" aims to represent the current state of the art in using Software Engineering (SE) methods in ABSS. It includes a mixture of theoretically oriented papers that describe frameworks, notations and methods adapted from SE and practice-oriented papers that demonstrate the application of SE methods in real world ABSS projects.

  12. Multi-level agent-based modeling - Bibliography

    CERN Document Server

    Morvan, Gildas

    2012-01-01

    This very short article aims to bring together the available bibliography on multi-level (or multi-layer, multi-perspective, multi-view, multi-scale, multi-resolution) agent-based modeling so that it is accessible to interested researchers.

  13. Mobile Agent-Based Directed Diffusion in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Kwon Taekyoung

    2007-01-01

    Full Text Available In the environments where the source nodes are close to one another and generate a lot of sensory data traffic with redundancy, transmitting all sensory data by individual nodes not only wastes the scarce wireless bandwidth, but also consumes a lot of battery energy. Instead of each source node sending sensory data to its sink for aggregation (the so-called client/server computing, Qi et al. in 2003 proposed a mobile agent (MA-based distributed sensor network (MADSN for collaborative signal and information processing, which considerably reduces the sensory data traffic and query latency as well. However, MADSN is based on the assumption that the operation of mobile agent is only carried out within one hop in a clustering-based architecture. This paper considers MA in multihop environments and adopts directed diffusion (DD to dispatch MA. The gradient in DD gives a hint to efficiently forward the MA among target sensors. The mobile agent paradigm in combination with the DD framework is dubbed mobile agent-based directed diffusion (MADD. With appropriate parameters set, extensive simulation shows that MADD exhibits better performance than original DD (in the client/server paradigm in terms of packet delivery ratio, energy consumption, and end-to-end delivery latency.

  14. Complete agent based simulation of mini-grids

    OpenAIRE

    González de Durana García, José María; Barambones Caramazana, Oscar; Kremers, Enrique; Viejo, Pablo

    2009-01-01

    EuroPES 2009 With eyes focused on simulation we review some of the main topics of Hybrid Renewable Energy Systems (HRES). Then we describe an Agent Based model of a simple example of one of such systems, a micro-grid, oriented to designing a decentralized Supervisor Control. The model has been implemented using AnyLogic.

  15. Agent-based Personal Network (PN) service architecture

    DEFF Research Database (Denmark)

    Jiang, Bo; Olesen, Henning

    2004-01-01

    In this paper we proposte a new concept for a centralized agent system as the solution for the PN service architecture, which aims to efficiently control and manage the PN resources and enable the PN based services to run seamlessly over different networks and devices. The working principle...

  16. The Geographic Information Grid System Based on Mobile Agent

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    We analyze the deficiencies of current application systems, and discuss the key requirements of distributed Geographic Information service (GIS). We construct the distributed GIS on grid platform. Considering the flexibility and efficiency, we integrate the mobile agent technology into the system. We propose a new prototype system, the Geographic Information Grid System (GIGS) based on mobile agent. This system has flexible services and high performance, and improves the sharing of distributed resources. The service strategy of the system and the examples are also presented.

  17. An Agent Based Model for Social Class Emergence

    Science.gov (United States)

    Yang, Xiaoxiang; Rodriguez Segura, Daniel; Lin, Fei; Mazilu, Irina

    We present an open system agent-based model to analyze the effects of education and the society-specific wealth transactions on the emergence of social classes. Building on previous studies, we use realistic functions to model how years of education affect the income level. Numerical simulations show that the fraction of an individual's total transactions that is invested rather than consumed can cause wealth gaps between different income brackets in the long run. In an attempt to incorporate the network effects, we also explore how the probability of interactions among agents depending on the spread of their income brackets affects wealth distribution.

  18. Agent-based Simulation of Processes in Medicine

    Czech Academy of Sciences Publication Activity Database

    Bošanský, Branislav

    Praha : Ústav informatiky AV ČR, v. v. i. & MATFYZPRESS, 2008 - (Hakl, F.), s. 19-27 ISBN 978-80-7378-054-8. [Doktorandské dny 2008 Ústavu informatiky AV ČR, v. v. i.. Jizerka (CZ), 29.09.2008-01.10.2008] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : multi - agent system s * agent -based simulation * process modelling * medicine Subject RIV: IN - Informatics, Computer Science

  19. SPY AGENT BASED SECURE DATA AGGREGATION IN WSN

    Directory of Open Access Journals (Sweden)

    T. Lathies Bhasker

    2014-12-01

    Full Text Available Wireless sensor network consist lot of sensor devices which are activated by using the battery power. These sensor devices are mostly used in hostile environment, military applications etc. So in this type of environment it is highly difficult to collect and transmit the data to the Sink without any data lost. In this paper we proposed SPY Agent based secure data aggregation scheme. Here one SPY Agent moves around the network and monitors the aggregator nodes i.e, the Cluster Heads for secure data collection. In the Simulation section we have analyzed our proposed architecture for both proactive and reactive protocols.

  20. Binding of Technetium-99m to plasma proteins: influence on the distribution of Tc-99m phosphate agents

    International Nuclear Information System (INIS)

    Plasma protein binding of Tc-99m was assessed in man after injection of various Tc-99m-labeled bone imaging agents. Of the five methods in which plasma proteins were precipitated to determine protein binding no correlation between them could be established. The ammonium sulfate method seemed to correlate well with dialysis filtration. Plasma obtained from patients injected with Tc-99m phosphate compounds was reinjected to rats. The bone uptake in these animals correlated linearly with the unbound activity in the injected plasma. Provided that no protein binding would occur, the bone uptake as well as the urinary excretion proved to be identical for Tc-99m HEDP, MDP, and PPi. Electrophoresis of Tc-99m PPi indicated that the intact complex may be uncharged, whereas at low ligand concentrations uncharged as well as negatively charged Tc-99m species are formed. Better methods are needed, however, to establish the presence of various Tc-99m species and their relative role in the kinetics of these compounds, and plasma protein binding

  1. The effects of moisture content, particle size and binding agent content on oil palm shell pellet quality parameters

    OpenAIRE

    Nelson Arzola; Alexander Gómez; Sonia Rincón

    2012-01-01

    Waste-to-energy represents a challenge for the oil palm industry worldwide. Bio-pellet production is an alternative way of adding value to oil palm biomass. This would mean that a product having major energy density becomes more mechanically stable and achieves better performance during combustion. This paper deals with oil palm shell pelleting; using binding agents having up to 25% mass keeping average particle size less than 1mm and moisture content up to 18.7% (d.b.) were evaluated. An exp...

  2. Using Agents in Web-Based Constructivist Collaborative Learning System

    Institute of Scientific and Technical Information of China (English)

    刘莹; 林福宗; 王雪

    2004-01-01

    Web-based learning systems are one of the most interesting topics in the area of the application of computers to education. Collaborative learning, as an important principle in constructivist learning theory, is an important instruction mode for open and distance learning systems. Through collaborative learning, students can greatly improve their creativity, exploration capability, and social cooperation. This paper used an agent-based coordination mechanism to respond to the requirements of an efficient and motivating learning process. This coordination mechanism is based on a Web-based constructivist collaborative learning system, in which students can learn in groups and interact with each other by several kinds of communication modes to achieve their learning objectives efficiently and actively. In this learning system, artificial agents represent an active part in the collaborative learning process; they can partially replace human instructors during the multi-mode interaction of the students.

  3. Technology of structure damage monitoring based on multi-agent

    Institute of Scientific and Technical Information of China (English)

    Hongbing Sun; Shenfang Yuan; Xia Zhao; Hengbao Zhou; Dong Liang

    2010-01-01

    The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent is a good candidate to be used in the field of structural health monitoring.A structural health monitoring system architecture based on multi-agent technology is proposed.The measurement system for aircraft airfoil is designed with FBG,strain gage,and corresponding signal processing circuit.The experiment to determine the location of the concentrate loading on the structure is carried on with the system combined with technologies of pattern recognition and multi-agent.The results show that the system can locate the concentrate loading of the aircraft airfoil at the accuracy of 91.2%.

  4. Differential Protection for Distributed Micro-Grid Based on Agent

    Directory of Open Access Journals (Sweden)

    ZHOU Bin

    2013-05-01

    Full Text Available The Micro-grid, even though not a replacement of the conventional centralized power transmission grid, plays a very important role in the success of rapid development of renewable energy resources technologies. Due to the facts of decentralization, independence and dynamic of sources within a Micro-grid, a high level automation of protection is a must. Multi-Agent system as a approach to handle distributed system issues has been developed. This paper presents an MAS based differential protection method for distributed micro-grid. The nodes within a micro-grid are divided into primary and backup protection zones. The agents follow predefined rules to take actions to protect the system and isolate the fault when it happens. Furthermore, an algorithm is proposed to achieve high availability in case of Agent itself malfunction. The method is using Matlab for simulation and shows it satisfies relay protection in terms of the selectivity, sensitivity, rapidity and reliability requirements.

  5. Multi-agent Based Hierarchy Simulation Models of Carrier-based Aircraft Catapult Launch

    Institute of Scientific and Technical Information of China (English)

    Wang Weijun; Qu Xiangju; Guo Linliang

    2008-01-01

    With the aid of multi-agent based modeling approach to complex systems,the hierarchy simulation models of carrier-based aircraft catapult launch are developed.Ocean,carrier,aircraft,and atmosphere are treated as aggregation agents,the detailed components like catapult,landing gears,and disturbances are considered as meta-agents,which belong to their aggregation agent.Thus,the model with two layers is formed i.e.the aggregation agent layer and the meta-agent layer.The information communication among all agents is described.The meta-agents within one aggregation agent communicate with each other directly by information sharing,but the meta-agents,which belong to different aggregation agents exchange their information through the aggregation layer fast,and then perceive it from the sharing environment,that is the aggregation agent.Thus,not only the hierarchy model is built,but also the environment perceived by each agent is specified.Meanwhile,the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved.Each agent involved in carrier-based aircraft catapult launch is depicted,with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier,aircraft,and landing gears.The models of reactive agents among them are derived based on tensors,and the perceived messages and inner frameworks of each agent are characterized.Finally,some results of a simulation instance are given.The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely.The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system.This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent,and it is convenient to expand,maintain,and reuse

  6. Agent-Based Framework for Implementing and Deploying of SOA

    OpenAIRE

    Alexandru Butoi; Gabriela Andreea Morar; Andreea Ilea

    2012-01-01

    In distributed organizational and business information systems’ contexts, Service-Oriented Architectures (SOA) provide standard-based and protocol independent solutions. Despite the advances in SOA models and design methodologies, the implementation and deployment of service choreographies are still made in an un-unified manner using the existing tools. We present a three-layered framework model based on deployment agents, which allows designing and implementing service choreographies in a un...

  7. An Agent Based Simulation Of Smart Metering Technology Adoption

    OpenAIRE

    Zhang,Tao; Nuttall, William J.

    2007-01-01

    Based on the classic behavioural theory ?the Theory of Planned Behaviour?, we develop an agent-based model to simulate the diffusion of smart metering technology in the electricity market. We simulate the emergent adoption of smart metering technology under different management strategies and economic regulations. Our research results show that in terms of boosting the take-off of smart meters in the electricity market, choosing the initial users on a random and geographically dispersed basis...

  8. Quantitative effects of antihydrophobic agents on binding constants and solubilities in water.

    OpenAIRE

    Breslow, R; Halfon, S.

    1992-01-01

    The effects of urea and of guanidinium chloride on binding constants in water for 6-(4-tert-butylanilino)-naphthalene-2-sulfonate and of bis(p-tert-butylphenyl) phosphate binding to beta-cyclodextrin and to N,N'-bis(6-beta-cyclo-dextrinyl)imidazolium ion have been determined. Their effects on the water solubility of p-tert-butylbenzyl alcohol and p-methylbenzyl alcohol have also been examined. Quantitative correlations show that the effects of these additives, which diminish hydrophobic effec...

  9. Simulating Interactive Learning Scenarios with Intelligent Pedagogical Agents in a Virtual World through BDI-Based Agents

    Directory of Open Access Journals (Sweden)

    Mohamed Soliman

    2013-04-01

    Full Text Available Intelligent Pedagogical Agents (IPAs are designed for pedagogical purposes to support learning in 3D virtual learning environments. Several benefits of IPAs have been found adding to support learning effectiveness. Pedagogical agents can be thought of as a central point of interaction between the learner and the learning environment. And hence, the intelligent behavior and functional richness of pedagogical agents have the potential to reward back into increased engagement and learning effectiveness. However, the realization of those agents remains to be a challenge based on intelligent agents in virtual worlds. This paper reports the challenging reasons and most importantly an approach for simplification. A simulation based on BDI agents is introduced opening the road for several extensions and experimentation before implementation of IPAs in a virtual world can take place. The simulation provides a proof-of concept based on three intelligent agents to represent an IPA, a learner, and learning object implemented in JACK and Jadex intelligent agent platforms. To that end, the paper exhibits the difficulties, resolutions, and decisions made when designing and implementing the learning scenario in both domains of the virtual world and the agent-based simulation while comparing the two agent platforms.

  10. Empirical agent-based modelling challenges and solutions

    CERN Document Server

    Barreteau, Olivier

    2014-01-01

    This instructional book showcases techniques to parameterise human agents in empirical agent-based models (ABM). In doing so, it provides a timely overview of key ABM methodologies and the most innovative approaches through a variety of empirical applications.  It features cutting-edge research from leading academics and practitioners, and will provide a guide for characterising and parameterising human agents in empirical ABM.  In order to facilitate learning, this text shares the valuable experiences of other modellers in particular modelling situations. Very little has been published in the area of empirical ABM, and this contributed volume will appeal to graduate-level students and researchers studying simulation modeling in economics, sociology, ecology, and trans-disciplinary studies, such as topics related to sustainability. In a similar vein to the instruction found in a cookbook, this text provides the empirical modeller with a set of 'recipes'  ready to be implemented. Agent-based modeling (AB...

  11. Simulation of convoy of unmanned vehicles using agent based modeling

    Science.gov (United States)

    Sharma, Sharad; Singh, Harpreet; Gerhart, G. R.

    2007-10-01

    There has been an increasing interest of unmanned vehicles keeping the importance of defense and security. A few models for a convoy of unmanned vehicle exist in literature. The objective of this paper is to exploit agent based modeling technique for a convoy of unmanned vehicles where each vehicle is an agent. Using this approach, the convoy of vehicles reaches a specified goal from a starting point. Each agent is associated with number of sensors. The agents make intelligent decisions based on sensor inputs and at the same time maintaining their group capability and behavior. The simulation is done for a battlefield environment from a single starting point to a single goal. This approach can be extended for multiple starting points to reach multiple goals. The simulation gives the time taken by the convoy to reach a goal from its initial position. In the battlefield environment, commanders make various tactical decisions depending upon the location of an enemy outpost, minefields, number of soldiers in platoons, and barriers. The simulation can help the commander to make effective decisions depending on battlefield, convoy and obstacles to reach a particular goal. The paper describes the proposed approach and gives the simulation results. The paper also gives problems for future research in this area.

  12. Mobile Arabchat: An Arabic Mobile-Based Conversational Agent

    Directory of Open Access Journals (Sweden)

    Mohammad Hijjawi

    2015-10-01

    Full Text Available The conversation automation/simulation between a user and machine evolved during the last years. A number of research-based systems known as conversational agents has been developed to address this challenge. A conversational Agent is a program that attempts to simulate conversations between the human and machine. Few of these programs targeted the mobile-based users to handle the conversations between them and a mobile device through an embodied spoken character. Wireless communication has been rapidly extended with the expansion of mobile services. Therefore, this paper discusses the proposing and developing a framework of a mobile-based conversational agent called Mobile ArabChat to handle the Arabic conversations between the Arab users and mobile device. To best of our knowledge, there are no such applications that address this challenge for Arab mobile-based users. An Android based application was developed in this paper, and it has been tested and evaluated in a large real environment. Evaluation results show that the Mobile ArabChat works properly, and there is a need for such a system for Arab users.

  13. Domain-based small molecule binding site annotation

    Directory of Open Access Journals (Sweden)

    Dumontier Michel

    2006-03-01

    Full Text Available Abstract Background Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule binding site protein sequence annotation is sparse. The Small Molecule Interaction Database (SMID, a database of protein domain-small molecule interactions, was created using structural data from the Protein Data Bank (PDB. More importantly it provides a means to predict small molecule binding sites on proteins with a known or unknown structure and unlike prior approaches, removes large numbers of false positive hits arising from transitive alignment errors, non-biologically significant small molecules and crystallographic conditions that overpredict ion binding sites. Description Using a set of co-crystallized protein-small molecule structures as a starting point, SMID interactions were generated by identifying protein domains that bind to small molecules, using NCBI's Reverse Position Specific BLAST (RPS-BLAST algorithm. SMID records are available for viewing at http://smid.blueprint.org. The SMID-BLAST tool provides accurate transitive annotation of small-molecule binding sites for proteins not found in the PDB. Given a protein sequence, SMID-BLAST identifies domains using RPS-BLAST and then lists potential small molecule ligands based on SMID records, as well as their aligned binding sites. A heuristic ligand score is calculated based on E-value, ligand residue identity and domain entropy to assign a level of confidence to hits found. SMID-BLAST predictions were validated against a set of 793 experimental small molecule interactions from the PDB, of which 472 (60% of predicted interactions identically matched the experimental small molecule and of these, 344 had greater than 80% of the binding site residues correctly identified. Further, we estimate that 45% of predictions which were not observed in the PDB validation set may be true positives. Conclusion By

  14. Identification of new binding sites of human transferrin incubated with organophosphorus agents via Q Exactive LC-MS/MS.

    Science.gov (United States)

    Sun, Fengjuan; Ding, Junjie; Yu, Huilan; Gao, Runli; Wang, Hongmei; Pei, Chengxin

    2016-06-01

    Organophosphorus agents (OPs) like sarin, VX, or soman could inhibit acetylcholinesterase activity and cause poisoning. OPs could bind many proteins, such as butyrylcholinesterase and albumin, and the adducts formed could identify the exposure. In this paper, we studied human transferrin, which was one of the proteins that could be labeled by OPs. Pure human transferrin was incubated with an overdose of organophosphorus agents, including sarin, soman, VX, tabun, cyclosarin, ethyl tabun, and propyl tabun, and then additional OPs was removed through dialysis. Trypsin was used to cleave the OP-treated proteins and Q Exactive liquid chromatography tandem mass spectrometry (Q Exactive LC-MS/MS) was used to identify them. The present study set out to accomplish two goals. The first goal was to find a good method for identifying multiple binding sites on a given protein through Q Exactive LC-MS/MS. The second goal was to investigate the labeled peptides when transferrin was incubated with a numerous molar excess of OPs. Results showed that tyrosine, lysine, and serine formed covalent bonds with OPs. Twenty OP-labeled sites were found: ten tyrosine sites (including two reported sites), seven lysine sites, and three serine sites. Characteristic fragments for labeled-tyrosine and labeled-lysine adducts were summarized in detail. In conclusion, the method by Q Exactive LC-MS/MS using in this present work is a good way to diagnose exposure to OPs accurately when the binding sites of OPs are uncertain. Novel modified peptides and the characteristic ions found in this work could help investigators assess exposure to OPs. PMID:27128859

  15. Model-Drive Architecture for Agent-Based Systems

    Science.gov (United States)

    Gradanin, Denis; Singh, H. Lally; Bohner, Shawn A.; Hinchey, Michael G.

    2004-01-01

    The Model Driven Architecture (MDA) approach uses a platform-independent model to define system functionality, or requirements, using some specification language. The requirements are then translated to a platform-specific model for implementation. An agent architecture based on the human cognitive model of planning, the Cognitive Agent Architecture (Cougaar) is selected for the implementation platform. The resulting Cougaar MDA prescribes certain kinds of models to be used, how those models may be prepared and the relationships of the different kinds of models. Using the existing Cougaar architecture, the level of application composition is elevated from individual components to domain level model specifications in order to generate software artifacts. The software artifacts generation is based on a metamodel. Each component maps to a UML structured component which is then converted into multiple artifacts: Cougaar/Java code, documentation, and test cases.

  16. Web-based supplier relationship framework using agent systems

    Institute of Scientific and Technical Information of China (English)

    Oboulhas Conrad Tsahat Onesime; XU Xiao-fei(徐晓飞); ZHAN De-chen(战德臣)

    2004-01-01

    In order to enable both manufacturers and suppliers to be profitable on today' s highly competitive markets, manufacturers and suppliers must be quick in selecting best partners establishing strategic relationship, and collaborating with each other so that they can satisfy the changing competitive manufacturing requirements. A web-based supplier relationships (SR) framework is therfore proposed using multi-agent systems and linear programming technique to reduce supply cost, increase flexibility and shorten response time. Web-based SR approach is an ideal platform for information exchange that helps buyers and suppliers to maintain the availability of materials in the right quantity, at the right place, and at the right time, and keep the customer-supplier relationship more transparent. A multi-agent system prototype was implemented by simulation, which shows the feasibility of the proposed architecture.

  17. Agent-based modelling of shifting cultivation field patterns, Vietnam

    DEFF Research Database (Denmark)

    Jepsen, Martin Rudbeck; Leisz, S.; Rasmussen, K.;

    2006-01-01

    modelling, and relying on empirical data from fieldwork and observations for parameterization of variables, the level of clustering in agricultural fields observed around a study village is reproduced. Agents in the model act to maximize labour productivity, which is based on potential yield and labour......Shifting cultivation in the Nghe An Province of Vietnam's Northern Mountain Region produces a characteristic land-cover pattern of small and larger fields. The pattern is the result of farmers cultivating either individually or in spatially clustered groups. Using spatially explicit agent-based...... costs associated with fencing of fields, and are faced with physical constraints. The simulation results are compared with land-cover data obtained from remote sensing. Comparisons are made on patterns as detected visually and using the mean nearest-neighbour ratio. Baseline simulation outputs show high...

  18. CORBA-Based Analysis of Multi Agent Behavior

    Institute of Scientific and Technical Information of China (English)

    Swapan Bhattacharya; Anirban Banerjee; Shibdas Bandyopadhyay

    2005-01-01

    An agent is a computer software that is capable of taking independent action on behalf of its user or owner. It is an entity with goals, actions and domain knowledge, situated in an environment. Multiagent systems comprises of multiple autonomous, interacting computer software, or agents. These systems can successfully emulate the entities active in a distributed environment. The analysis of multiagent behavior has been studied in this paper based on a specific board game problem similar to the famous problem of GO. In this paper a framework is developed to define the states of the multiagent entities and measure the convergence metrics for this problem. An analysis of the changes of states leading to the goal state is also made. We support our study of multiagent behavior by simulations based on a CORBA framework in order to substantiate our findings.

  19. Mobile Agent Based Framework for Integrating Digital Library System

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Few of the current approaches to achieve the integration of digital library system have considered the influence of network factors on quality of service for the integration system of digital libraries. For this reason, a mobile agent based framework for integrating digital library system is proposed. Based on this framework, a prototype system is implemented and the key technique for it are described. Compared with the current approaches, using mobile agent technique to achieve the integration of digital library system can not only avoid transmitting a lot of data on the network, lower the dependence on network bandwidth for the system, but also improve the quality of service for the integration system of digital libraries in intermitted or unreliable network connection settings.

  20. Propagation Modeling of Food Safety Crisis Information Update Based on the Multi-agent System

    OpenAIRE

    Meihong Wu; Jingfei Yang; Zhiling Hong

    2015-01-01

    This study propose a new multi-agent system frame based on epistemic default complex adaptive theory and use the agent based simulation and modeling the information updating process to study food safety crisis information dissemination. Then, we explore interaction effect between each agent in food safety crisis information dissemination at the current environment and mostly reveals how the government agent, food company agent and network media agent influence users confidence in food safety....

  1. DAIDS: a Distributed, Agent-based Information Dissemination System

    Directory of Open Access Journals (Sweden)

    Pete Haglich

    2007-10-01

    Full Text Available The Distributed Agent-Based Information Dissemination System (DAIDS concept was motivated by the need to share information among the members of a military tactical team in an atmosphere of extremely limited or intermittent bandwidth. The DAIDS approach recognizes that in many cases communications limitations will preclude the complete sharing of all tactical information between the members of the tactical team. Communications may be limited by obstructions to the line of sight between platforms; electronic warfare; or environmental conditions, or just contention from other users of that bandwidth. Since it may not be possible to achieve a complete information exchange, it is important to prioritize transmissions so the most critical information from the standpoint of the recipient is disseminated first. The challenge is to be able to determine which elements of information are the most important to each teammate. The key innovation of the DAIDS concept is the use of software proxy agents to represent the information needs of the recipient of the information. The DAIDS approach uses these proxy agents to evaluate the content of a message in accordance with the context and information needs of the recipient platform (the agent's principal and prioritize the message for dissemination. In our research we implemented this approach and demonstrated that it provides nearly a reduction in transmission times for critical tactical reports by up to a factor of 30 under severe bandwidth limitations.

  2. Endogenizing geopolitical boundaries with agent-based modeling

    Science.gov (United States)

    Cederman, Lars-Erik

    2002-01-01

    Agent-based modeling promises to overcome the reification of actors. Whereas this common, but limiting, assumption makes a lot of sense during periods characterized by stable actor boundaries, other historical junctures, such as the end of the Cold War, exhibit far-reaching and swift transformations of actors' spatial and organizational existence. Moreover, because actors cannot be assumed to remain constant in the long run, analysis of macrohistorical processes virtually always requires “sociational” endogenization. This paper presents a series of computational models, implemented with the software package REPAST, which trace complex macrohistorical transformations of actors be they hierarchically organized as relational networks or as collections of symbolic categories. With respect to the former, dynamic networks featuring emergent compound actors with agent compartments represented in a spatial grid capture organizational domination of the territorial state. In addition, models of “tagged” social processes allows the analyst to show how democratic states predicate their behavior on categorical traits. Finally, categorical schemata that select out politically relevant cultural traits in ethnic landscapes formalize a constructivist notion of national identity in conformance with the qualitative literature on nationalism. This “finite-agent method”, representing both states and nations as higher-level structures superimposed on a lower-level grid of primitive agents or cultural traits, avoids reification of agency. Furthermore, it opens the door to explicit analysis of entity processes, such as the integration and disintegration of actors as well as boundary transformations. PMID:12011409

  3. Endogenizing geopolitical boundaries with agent-based modeling.

    Science.gov (United States)

    Cederman, Lars-Erik

    2002-05-14

    Agent-based modeling promises to overcome the reification of actors. Whereas this common, but limiting, assumption makes a lot of sense during periods characterized by stable actor boundaries, other historical junctures, such as the end of the Cold War, exhibit far-reaching and swift transformations of actors' spatial and organizational existence. Moreover, because actors cannot be assumed to remain constant in the long run, analysis of macrohistorical processes virtually always requires "sociational" endogenization. This paper presents a series of computational models, implemented with the software package REPAST, which trace complex macrohistorical transformations of actors be they hierarchically organized as relational networks or as collections of symbolic categories. With respect to the former, dynamic networks featuring emergent compound actors with agent compartments represented in a spatial grid capture organizational domination of the territorial state. In addition, models of "tagged" social processes allows the analyst to show how democratic states predicate their behavior on categorical traits. Finally, categorical schemata that select out politically relevant cultural traits in ethnic landscapes formalize a constructivist notion of national identity in conformance with the qualitative literature on nationalism. This "finite-agent method", representing both states and nations as higher-level structures superimposed on a lower-level grid of primitive agents or cultural traits, avoids reification of agency. Furthermore, it opens the door to explicit analysis of entity processes, such as the integration and disintegration of actors as well as boundary transformations. PMID:12011409

  4. Cognitive Modeling for Agent-Based Simulation of Child Maltreatment

    Science.gov (United States)

    Hu, Xiaolin; Puddy, Richard

    This paper extends previous work to develop cognitive modeling for agent-based simulation of child maltreatment (CM). The developed model is inspired from parental efficacy, parenting stress, and the theory of planned behavior. It provides an explanatory, process-oriented model of CM and incorporates causality relationship and feedback loops from different factors in the social ecology in order for simulating the dynamics of CM. We describe the model and present simulation results to demonstrate the features of this model.

  5. Opinion transmission in organizations: an agent-based modeling approach

    OpenAIRE

    Rouchier, Juliette; Tubaro, Paola; Emery, Cécile

    2014-01-01

    This paper builds a theoretical framework to detect the conditions under which social influence enables persistence of a shared opinion among members of an organization over time, despite membership turnover. It develops agent-based simulations of opinion evolution in an advice network, whereby opinion is defined in the broad sense of shared understandings on a matter that is relevant for an organization’s activities, and on which members have some degree of discretion. We combine a micro-lev...

  6. From agent-based models to artificial economies

    OpenAIRE

    Teglio, Andrea

    2011-01-01

    The aim of this thesis is to propose and illustrate an alternative approach to economic modeling and policy design that is grounded in the innovative field of agent-based computational economics (ACE). The recent crisis pointed out the fundamental role played by macroeconomic policy design in order to preserve social welfare, and the consequent necessity of understanding the effects of coordinated policy measures on the economic system. Classic approaches to macroeconomic modeling, mainly rep...

  7. Operational-level naval planning using agent-based simulation

    OpenAIRE

    Ercetin, Askin.

    2001-01-01

    This thesis uses agent-based modeling techniques to develop a simulation of the operational-level naval planning process. The simulation serves as an initial exploratory laboratory for analyzing the consequences of the force allocation, force deployment, and force movement decisions made by operational-level naval commanders during times of conflict or crisis. This model will hopefully help decision-makers in gaining insight into the naval planning process and enable them to make more informe...

  8. Agent-based distributed hierarchical control of dc microgrid systems

    DEFF Research Database (Denmark)

    Meng, Lexuan; Vasquez, Juan Carlos; Guerrero, Josep M.;

    2014-01-01

    In order to enable distributed control and management for microgrids, this paper explores the application of information consensus and local decisionmaking methods formulating an agent based distributed hierarchical control system. A droop controlled paralleled DC/DC converter system is taken as ....... Standard genetic algorithm is applied in each local control system in order to search for a global optimum. Hardware-in-Loop simulation results are shown to demonstrate the effectiveness of the method....

  9. Multispace Behavioral Model for Face-Based Affective Social Agents

    OpenAIRE

    Ali Arya; Steve DiPaola

    2007-01-01

    This paper describes a behavioral model for affective social agents based on three independent but interacting parameter spaces: knowledge, personality, and mood. These spaces control a lower-level geometry space that provides parameters at the facial feature level. Personality and mood use findings in behavioral psychology to relate the perception of personality types and emotional states to the facial actions and expressions through two-dimensional models for personality and emotion. Knowl...

  10. An Agent-based Framework for Speech Investigation

    OpenAIRE

    Walsh, Michael; O'Hare, G.M.P.; Carson-Berndsen, Julie

    2005-01-01

    This paper presents a novel agent-based framework for investigating speech recognition which combines statistical data and explicit phonological knowledge in order to explore strategies aimed at augmenting the performance of automatic speech recognition (ASR) systems. This line of research is motivated by a desire to provide solutions to some of the more notable problems encountered, including in particular the problematic phenomena of coarticulation, underspecified input...

  11. An Agent-Based Dialogical Model with Fuzzy Attitudes

    OpenAIRE

    Piter Dykstra; Wander Jager; Corinna Elsenbroich; Rineke Verbrugge; Gerard Renardel de Lavalette

    2015-01-01

    This paper presents an extension to an agent-based model of opinion dynamics built on dialogical logic DIAL. The extended model tackles a pervasive problem in argumentation logics: the difference between linguistic and logical inconsistency. Using fuzzy logic, the linear ordering of opinions, used in DIAL, is replaced by a set of partial orderings leading to a new, nonstandard notion of consistency as convexity of sets of statements. DIAL allows the modelling of the interplay of social struct...

  12. Online analysis and visualization of agent based models

    OpenAIRE

    Grignard, Arnaud; Drogoul, Alexis; Zucker, Jean-Daniel

    2013-01-01

    International audience Agent-based modeling is used to study many kind of complex systems in different fields such as biology, ecology, or sociology. Visualization of the execution of a such complex systems is crucial in the capacity to apprehend its dynamics. The ever increasing complexification of requirements asked by the modeller has highlighted the need for more powerful tools than the existing ones to represent, visualize and interact with a simulation and extract data online to disc...

  13. Agent Based Model of Young Researchers in Higher Education Institutions

    OpenAIRE

    Josip Stepanic; Mirjana Pejic Bach; Josip Kasac

    2013-01-01

    Group of young researchers in higher education institutions in general perform demandable tasks with relatively high contribution to institutions’ and societies’ innovation production. In order to analyse in more details interaction among young researchers and diverse institutions in society, we aim toward developing the numerical simulation, agent-based model. This article presents foundations of the model, preliminary results of its simulation along with perspectives of its further deve...

  14. AGENT-BASED NEGOTIATION PLATFORM IN COLLABORATIVE NETWORKED ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Adina-Georgeta CREȚAN

    2014-05-01

    Full Text Available This paper proposes an agent-based platform to model and support parallel and concurrent negotiations among organizations acting in the same industrial market. The underlying complexity is to model the dynamic environment where multi-attribute and multi-participant negotiations are racing over a set of heterogeneous resources. The metaphor Interaction Abstract Machines (IAMs is used to model the parallelism and the non-deterministic aspects of the negotiation processes that occur in Collaborative Networked Environment.

  15. Deep Learning in Agent-Based Models: A Prospectus

    OpenAIRE

    Hoog, Sander van der

    2016-01-01

    A very timely issue for economic agent-based models (ABMs) is their empirical estimation. This paper describes a line of research that could resolve the issue by using machine learning techniques, using multi-layer artificial neural networks (ANNs), or so called Deep Nets. The seminal contribution by Hinton et al. (2006) introduced a fast and efficient training algorithm called Deep Learning, and there have been major breakthroughs in machine learning ever since. Economics has not yet benefit...

  16. Graphene-based nanomaterials as molecular imaging agents.

    Science.gov (United States)

    Garg, Bhaskar; Sung, Chu-Hsun; Ling, Yong-Chien

    2015-01-01

    Molecular imaging (MI) is a noninvasive, real-time visualization of biochemical events at the cellular and molecular level within tissues, living cells, and/or intact objects that can be advantageously applied in the areas of diagnostics, therapeutics, drug discovery, and development in understanding the nanoscale reactions including enzymatic conversions and protein-protein interactions. Consequently, over the years, great advancement has been made in the development of a variety of MI agents such as peptides, aptamers, antibodies, and various nanomaterials (NMs) including single-walled carbon nanotubes. Recently, graphene, a material popularized by Geim & Novoselov, has ignited considerable research efforts to rationally design and execute a wide range of graphene-based NMs making them an attractive platform for developing highly sensitive MI agents. Owing to their exceptional physicochemical and biological properties combined with desirable surface engineering, graphene-based NMs offer stable and tunable visible emission, small hydrodynamic size, low toxicity, and high biocompatibility and thus have been explored for in vitro and in vivo imaging applications as a promising alternative of traditional imaging agents. This review begins by describing the intrinsic properties of graphene and the key MI modalities. After which, we provide an overview on the recent advances in the design and development as well as physicochemical properties of the different classes of graphene-based NMs (graphene-dye conjugates, graphene-antibody conjugates, graphene-nanoparticle composites, and graphene quantum dots) being used as MI agents for potential applications including theranostics. Finally, the major challenges and future directions in the field will be discussed. PMID:25857851

  17. Formalizing argument-based agent interaction in electronic institutions

    OpenAIRE

    Chesñevar, Carlos Iván

    2001-01-01

    During the last decade the notion of agent has gained acceptance within the AI community, mainly due to its adequacy to formalize complex environments. Agents can be thought as active software objects, which may be autonomous and able to perceive, reason, act, and interact with other agents. When agents interact with each other, a multi-agent system (MAS) arises.

  18. [125I](S)-trans-7-OH-PIPAT: A potential SPECT imaging agent for sigma binding sites

    International Nuclear Information System (INIS)

    [125I](S)-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)]aminotetralin ([125I](s)-trans-7-OH-PIPAT) has been prepared as an iodinated radioligand for studying the sigma binding site. [125I](s)-trans-7-OH-PIPAT binds to rat cerebellar membranes with a Kd=1.67 ± 0.07 nM and Bmax =240 ± 72 fmol/mg of protein (determined in the presence of 15 nM spiperone). This new ligand appears to bind to only one site with Hill coefficients close to unity. Inhibition constants for competing ligands determined in the cerebellar tissue homogenates (in the presence of 15 nM spiperone) are closely comparable to inhibition constants determined in the whole brain tissue homogenates (in the absence of spiperone). Furthermore, these inhibition constants are consistent with the values reported for typical sigma ligands. In vivo uptake of [125I](S)-trans-7-OH-PIPAT in the rat brain is initially high (2.52% dose/organ at 2 min post i.v. injection) and displays a rapid washout from the brain (0.8% dose/organ at 30 min post i.v. injection). Uptake of [125I](S)-trans-7-OH-PIPAT shows moderate target to non-target ratios of 30 minutes (1.54, 1.66 and 1.92 for cerebellar, hypothalamic and hindbrain uptake over striatal uptake, respectively). Pre-injection with haloperidol reduced these ratios to unity suggesting that the ligand binds specifically to haloperidol-sensitive sites in vivo. The selectivity and affinity of [125I](S)-trans-7-OH-PIPAT suggest that this new iodinated ligand may be useful for in vitro studies of the sigma sites and can be used in vivo as a potential SPECT imaging agent

  19. ZnO nanowire-based glucose biosensors with different coupling agents

    International Nuclear Information System (INIS)

    Highlights: ► Fabrication of ZnO nanowire-based glucose biosensors using different coupling agents. ► Highest sensitivity for (3-aminopropyl)methyldiethoxysilane-treated biosensor. ► Larger amount of glucose oxidase and lower electron transfer resistance for (3-aminopropyl)methyldiethoxysilane-treated biosensor. - Abstract: ZnO-nanowire-based glucose biosensors were fabricated by immobilizing glucose oxidase (GOx) onto a linker attached to ZnO nanowires. Different coupling agents were used, namely (3-aminopropyl)trimethoxysilane (APTMS), (3-aminopropyl)triethoxysilane (APTES), and (3-aminopropyl)methyldiethoxysilane (APS), to increase the affinity of GOx binding to ZnO nanowires. The amount of GOx immobilized on the ZnO nanowires, the performance, sensitivity, and Michaelis–Menten constant of each biosensor, and the electron transfer resistance through the biosensor were all measured in order to investigate the effect of the coupling agent on the ZnO nanowire-based biosensor. Among the different biosensors, the APS-treated biosensor had the highest sensitivity (17.72 μA cm−2 mM−1) and the lowest Michaelis–Menten constant (1.37 mM). Since APS-treated ZnO nanowires showed the largest number of C-N groups and the lowest electron transfer resistance through the biosensor, we concluded that these properties were the key factors in the performance of APS-treated glucose biosensors.

  20. ZnO nanowire-based glucose biosensors with different coupling agents

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Juneui [Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Lim, Sangwoo, E-mail: swlim@yonsei.ac.kr [Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749 (Korea, Republic of)

    2013-01-15

    Highlights: Black-Right-Pointing-Pointer Fabrication of ZnO nanowire-based glucose biosensors using different coupling agents. Black-Right-Pointing-Pointer Highest sensitivity for (3-aminopropyl)methyldiethoxysilane-treated biosensor. Black-Right-Pointing-Pointer Larger amount of glucose oxidase and lower electron transfer resistance for (3-aminopropyl)methyldiethoxysilane-treated biosensor. - Abstract: ZnO-nanowire-based glucose biosensors were fabricated by immobilizing glucose oxidase (GOx) onto a linker attached to ZnO nanowires. Different coupling agents were used, namely (3-aminopropyl)trimethoxysilane (APTMS), (3-aminopropyl)triethoxysilane (APTES), and (3-aminopropyl)methyldiethoxysilane (APS), to increase the affinity of GOx binding to ZnO nanowires. The amount of GOx immobilized on the ZnO nanowires, the performance, sensitivity, and Michaelis-Menten constant of each biosensor, and the electron transfer resistance through the biosensor were all measured in order to investigate the effect of the coupling agent on the ZnO nanowire-based biosensor. Among the different biosensors, the APS-treated biosensor had the highest sensitivity (17.72 {mu}A cm{sup -2} mM{sup -1}) and the lowest Michaelis-Menten constant (1.37 mM). Since APS-treated ZnO nanowires showed the largest number of C-N groups and the lowest electron transfer resistance through the biosensor, we concluded that these properties were the key factors in the performance of APS-treated glucose biosensors.

  1. Markov chain aggregation for agent-based models

    CERN Document Server

    Banisch, Sven

    2016-01-01

    This self-contained text develops a Markov chain approach that makes the rigorous analysis of a class of microscopic models that specify the dynamics of complex systems at the individual level possible. It presents a general framework of aggregation in agent-based and related computational models, one which makes use of lumpability and information theory in order to link the micro and macro levels of observation. The starting point is a microscopic Markov chain description of the dynamical process in complete correspondence with the dynamical behavior of the agent-based model (ABM), which is obtained by considering the set of all possible agent configurations as the state space of a huge Markov chain. An explicit formal representation of a resulting “micro-chain” including microscopic transition rates is derived for a class of models by using the random mapping representation of a Markov process. The type of probability distribution used to implement the stochastic part of the model, which defines the upd...

  2. A Multi Agent Based Model for Airport Service Planning

    Directory of Open Access Journals (Sweden)

    W.H. Ip

    2010-09-01

    Full Text Available Aviation industry is highly dynamic and demanding in nature that time and safety are the two most important factors while one of the major sources of delay is aircraft on ground because of it complexity, a lot of machinery like vehicles are involved and lots of communication are involved. As one of the aircraft ground services providers in Hong Kong International Airport, China Aircraft Services Limited (CASL aims to increase competitiveness by better its service provided while minimizing cost is also needed. One of the ways is to optimize the number of maintenance vehicles allocated in order to minimize chance of delay and also operating costs. In the paper, an agent-based model is proposed for support decision making in vehicle allocation. The overview of the aircrafts ground services procedures is firstly mentioned with different optimization methods suggested by researchers. Then, the agent-based approach is introduced and in the latter part of report and a multi-agent system is built and proposed which is decision supportive for CASL in optimizing the maintenance vehicles' allocation. The application provides flexibility for inputting number of different kinds of vehicles, simulation duration and aircraft arrival rate in order to simulation different scenarios which occurs in HKIA.

  3. Statistical Agent Based Modelization of the Phenomenon of Drug Abuse

    Science.gov (United States)

    di Clemente, Riccardo; Pietronero, Luciano

    2012-07-01

    We introduce a statistical agent based model to describe the phenomenon of drug abuse and its dynamical evolution at the individual and global level. The agents are heterogeneous with respect to their intrinsic inclination to drugs, to their budget attitude and social environment. The various levels of drug use were inspired by the professional description of the phenomenon and this permits a direct comparison with all available data. We show that certain elements have a great importance to start the use of drugs, for example the rare events in the personal experiences which permit to overcame the barrier of drug use occasionally. The analysis of how the system reacts to perturbations is very important to understand its key elements and it provides strategies for effective policy making. The present model represents the first step of a realistic description of this phenomenon and can be easily generalized in various directions.

  4. Statistical Agent Based Modelization of the Phenomenon of Drug Abuse

    CERN Document Server

    Di Clemente, Riccardo; 10.1038/srep00532

    2012-01-01

    We introduce a statistical agent based model to describe the phenomenon of drug abuse and its dynamical evolution at the individual and global level. The agents are heterogeneous with respect to their intrinsic inclination to drugs, to their budget attitude and social environment. The various levels of drug use were inspired by the professional description of the phenomenon and this permits a direct comparison with all available data. We show that certain elements have a great importance to start the use of drugs, for example the rare events in the personal experiences which permit to overcame the barrier of drug use occasionally. The analysis of how the system reacts to perturbations is very important to understand its key elements and it provides strategies for effective policy making. The present model represents the first step of a realistic description of this phenomenon and can be easily generalized in various directions.

  5. Building Distributed Web GIS: A Mobile-Agent Based Approach

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The diversity of GISs and the wide-spread availability of WWWhave l e d to an increasing amount of research on integrating a variety of heterogeneous and autonomous GISs in a cooperative environment to construct a new generation o f GIS characterizing in open architecture, distributed computation, interoperabi lity, and extensibility. Our on-going research project MADGI S (Mobile Agent based Distributed Geographic Information System) is reported, in which we pro pose the architecture of MADGIS to meet the requirements of integrating distribu ted GIS applications under Internet environment. We first describe the architect ure of MADGIS, and detailed discussions focusing on the structure of client site , server site and mobile agent in MADGIS. Then we explore key techniques for MAD GIS implementation.

  6. Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold.

    Science.gov (United States)

    Teng, Peng; Huo, Da; Nimmagadda, Alekhya; Wu, Jianfeng; She, Fengyu; Su, Ma; Lin, Xiaoyang; Yan, Jiyu; Cao, Annie; Xi, Chuanwu; Hu, Yong; Cai, Jianfeng

    2016-09-01

    Prevalence of drug-resistant bacteria has emerged to be one of the greatest threats in the 21st century. Herein, we report the development of a series of small molecular antibacterial agents that are based on the acylated reduced amide scaffold. These molecules display good potency against a panel of multidrug-resistant Gram-positive and Gram-negative bacterial strains. Meanwhile, they also effectively inhibit the biofilm formation. Mechanistic studies suggest that these compounds kill bacteria by compromising bacterial membranes, a mechanism analogous to that of host-defense peptides (HDPs). The mechanism is further supported by the fact that the lead compounds do not induce resistance in MRSA bacteria even after 14 passages. Lastly, we also demonstrate that these molecules have therapeutic potential by preventing inflammation caused by MRSA induced pneumonia in a rat model. This class of compounds could lead to an appealing class of antibiotic agents combating drug-resistant bacterial strains. PMID:27526720

  7. Design of an Agent Based Traffic-Information Collection System

    Directory of Open Access Journals (Sweden)

    Kenedy Aliila Greyson

    2012-11-01

    Full Text Available Currently, traffic congestions are common events in road networks of main cities in developing countries. It has been observed that, the size of congestion increases year after year. For traffic congestion management to work efficiently, sufficiently and accurately information are needed. In this research we present an alternative method using agent technology to collect and manipulate data so as to be used in optimizing the vehicle flow within the road networks. The objective is to design an agent based system to provide sufficient and accurate information used in traffic flow management, and vehicle traffic congestion mitigation. The implementation approach is presented. The case study is a portion of the road network from the city of Dar es Salaam.

  8. A Novel Architecture of Agent based Crawling for OAI Resources

    Directory of Open Access Journals (Sweden)

    J.P.Gupta

    2010-07-01

    Full Text Available Nowadays, most of the search engines are competing to index as much of the Surface Web as possible with leaving a lurch at the OAI content (pdf documents, which holds a huge amount of information than surface web. In this paper, a novel framework for OAI-PMH based Crawler is being proposed that uses agents to extract the metadata about the OAI resources and store them in a repository which is later on queried through the OAI-PMH layer to generate the XML pages containing the metadata. These pages are further added to the search engines repository for indexing that makes in turn increases therelevancy of Search Engine. Agents are being used to parallelizethe whole process so that metadata extraction from multiple resources can be carried out simultaneously.

  9. Capacity Analysis for Parallel Runway through Agent-Based Simulation

    Directory of Open Access Journals (Sweden)

    Yang Peng

    2013-01-01

    Full Text Available Parallel runway is the mainstream structure of China hub airport, runway is often the bottleneck of an airport, and the evaluation of its capacity is of great importance to airport management. This study outlines a model, multiagent architecture, implementation approach, and software prototype of a simulation system for evaluating runway capacity. Agent Unified Modeling Language (AUML is applied to illustrate the inbound and departing procedure of planes and design the agent-based model. The model is evaluated experimentally, and the quality is studied in comparison with models, created by SIMMOD and Arena. The results seem to be highly efficient, so the method can be applied to parallel runway capacity evaluation and the model propose favorable flexibility and extensibility.

  10. Self-assembled cardanol azo derivatives as antifungal agent with chitin-binding ability.

    Science.gov (United States)

    Mahata, Denial; Mandal, Santi M; Bharti, Rashmi; Gupta, Vinay Krishna; Mandal, Mahitosh; Nag, Ahindra; Nando, Golok B

    2014-08-01

    Cardanol is a non-isoprenoic phenolic lipid-mixture of distilled cashew nut shell liquid obtained from Anacardium occidentale. Herein, cardanol is purified from cashew nut shell liquid (CNSL) and synthesized to new compounds with different azo amphiphiles. These synthesized compounds are allowed to self-assembled in hydrophobic environment and checked antifungal activity against Candida albicans. Self-assembled structure of CABA showed higher antifungal activity (16μg/mL) and chitin-binding ability in comparison to CAP and CANB. Furthermore, the self-assembled azo amphiphiles are immobilized with silver ions to prepare hydrogel which showed eight folds enhanced antifungal activity. Toxicity is reduced by several folds of self-assembled or hydrogel structure in comparison to pure compounds. Thus, the self-assembled structure of amphiphiles and their hydrogels have been found to be new macromolecules of interest with potential use as antifungal drugs. PMID:24836571

  11. Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents

    Directory of Open Access Journals (Sweden)

    Man-Yi Ye

    2013-04-01

    Full Text Available Several rhein-phosphonate derivatives (5a–c were synthesized and evaluated for in vitro cytotoxicity against HepG-2, CNE, Spca-2, Hela and Hct-116 cell lines. Some compounds showed relatively high cytotoxicity. Especially compounds 5b exhibited the strongest cytotoxicity against HepG-2 and Spca-2 cells (IC50 was 8.82 and 9.01 µM, respectively. All the synthesized compounds exhibited low cytotoxicity against HUVEC cells. Further experiments proved that 5b could disturb the cell cycle in HepG-2 cells and induce apoptosis. In addition, the binding properties of a model conjugate 5b to DNA were investigated by methods (UV-Vis, fluorescence, CD spectroscopy. Results indicated that 5b showed moderate ability to interact ct-DNA.

  12. Control of actin-based motility through localized actin binding

    International Nuclear Information System (INIS)

    A wide variety of cell biological and biomimetic systems use actin polymerization to drive motility. It has been suggested that an object such as a bacterium can propel itself by self-assembling a high concentration of actin behind it, if it is repelled by actin. However, it is also known that it is essential for the moving object to bind actin. Therefore, a key question is how the actin tail can propel an object when it both binds and repels the object. We present a physically consistent Brownian dynamics model for actin-based motility that includes the minimal components of the dendritic nucleation model and allows for both attractive and repulsive interactions between actin and a moveable disc. We find that the concentration gradient of filamentous actin generated by polymerization is sufficient to propel the object, even with moderately strong binding interactions. Additionally, actin binding can act as a biophysical cap, and may directly control motility through modulation of network growth. Overall, this mechanism is robust in that it can drive motility against a load up to a stall pressure that depends on the Young’s modulus of the actin network and can explain several aspects of actin-based motility. (paper)

  13. Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

    Science.gov (United States)

    Siles, Rogelio; Ackley, J Freeland; Hadimani, Mallinath B; Hall, John J; Mugabe, Benon E; Guddneppanavar, Rajsekhar; Monk, Keith A; Chapuis, Jean-Charles; Pettit, George R; Chaplin, David J; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M; Pinney, Kevin G

    2008-03-01

    Several stilbenoid compounds having structural similarity to the combretastatin group of natural products and characterized by the incorporation of two nitrogen-bearing groups (amine, nitro, serinamide) have been prepared by chemical synthesis and evaluated in terms of biochemical and biological activity. The 2',3'-diamino B-ring analogue 17 demonstrated remarkable cytotoxicity against selected human cancer cell lines in vitro (average GI 50 = 13.9 nM) and also showed good activity in regard to inhibition of tubulin assembly (IC 50 = 2.8 microM). In addition, a single dose (10 mg/kg) of compound 17 caused a 40% tumor-selective blood flow shutdown in tumor-bearing SCID mice at 24 h, thus suggesting the potential value of this compound and its corresponding salt formulations as new vascular-disrupting agents. PMID:18303849

  14. Agent Based Trust Management in Distributed E-Business Environment

    Directory of Open Access Journals (Sweden)

    E.Sathiyamoorthy

    2010-02-01

    Full Text Available In e-business environment, Trust Management is an important factor that is necessary for alltransactions. The basic e-business requirements like non-reputation of both trustee and of trustier arefound to be problem arising due to lack of trust information. Many environments use relatively simplemechanism to calculate trust, for example, e-bay is a typical example for reputation based system built oncentralized model of trust. Several frameworks have been designed by researchers based on reputationmodels, but all these mechanisms failed in preventing users from producing false information whilemaking a reputation. Also sufficient information regarding the new users who have just started doingbusiness online is not available.To overcome the drawbacks of the existing system, a new trust management framework isproposed in this paper for a distributed e-business environment. The model offers the merits of previoustrust management systems based on Trusted third parties namely Policy-based and Reputation basedmodels. It also ensures trustworthy business transactions between the business entities and provides amore appropriate trust rating value calculated on the basis of mathematical model taking into accountthe feedback of peers and direct experience and access policy. The implementation using Agents is foundto be more efficient with respect to time and trust calculation when compared to the model which worksunder non Agent environment.

  15. Agent-based modelling of consumer energy choices

    Science.gov (United States)

    Rai, Varun; Henry, Adam Douglas

    2016-06-01

    Strategies to mitigate global climate change should be grounded in a rigorous understanding of energy systems, particularly the factors that drive energy demand. Agent-based modelling (ABM) is a powerful tool for representing the complexities of energy demand, such as social interactions and spatial constraints. Unlike other approaches for modelling energy demand, ABM is not limited to studying perfectly rational agents or to abstracting micro details into system-level equations. Instead, ABM provides the ability to represent behaviours of energy consumers -- such as individual households -- using a range of theories, and to examine how the interaction of heterogeneous agents at the micro-level produces macro outcomes of importance to the global climate, such as the adoption of low-carbon behaviours and technologies over space and time. We provide an overview of ABM work in the area of consumer energy choices, with a focus on identifying specific ways in which ABM can improve understanding of both fundamental scientific and applied aspects of the demand side of energy to aid the design of better policies and programmes. Future research needs for improving the practice of ABM to better understand energy demand are also discussed.

  16. Using the Agent-Based Modeling in Economic Field

    Directory of Open Access Journals (Sweden)

    Nora Mihail

    2006-12-01

    Full Text Available The last ten years of the XX century has been the witnesses of the apparition of a new scientific field, which is usually defined as the study of “Complex adaptive systems”. This field, generic named Complexity Sciences, shares its subject, the general proprieties of complex systems across traditional disciplinary boundaries, with cybernetics and general systems theory. But the development of Complexity Sciences approaches is determined by the extensive use of Agent-Based-Models (ABM as a research tool and an emphasis on systems, such as markets, populations or ecologies, which are less integrated or “organized” than the ones, such as companies and economies, intensively studied by the traditional disciplines. For ABM, a complex system is a system of individual agents who have the freedom to act in ways that are not always totally predictable, and whose actions are interconnected such that one agent’s actions changes the context (environment for other agents. These are many examples of such complex systems: the stock market, the human body immune system, a business organization, an institution, a work-team, a family etc.

  17. Secure Mobile Agent based Information Gathering in Wireless Network

    Directory of Open Access Journals (Sweden)

    Ashish Kumar Srivastava

    2010-08-01

    Full Text Available Nowadays, everything is moving towards the wireless environment to bring the smartness to the society. In this situation, it is necessary to bring the smart technologies in the wireless environment. By considering this in mind, we concentrated to incorporate the mobile agent in the wireless environment to gather information. The problem with the mobile agent (multi hop mobile agent is the security issue in gathering information from number of remote hosts. To overcome this security issue, an 3-ID algorithm is available which will verify the integrity of the data as well as provide confidentiality to the data. But this algorithm requires moretime complexity for verification of the previously collected allinformation integrity. To optimize the verification time complexity, this 3-ID algorithm [9][10] is modified to verify only N, N/2, N/3 or N/4 previous host information based on the requirements. The experimental results in the wireless environment proves that the verification time of the integrity will obviously less when compare to its original model.

  18. AGENT-BASED DISTRIBUTION GRID OPERATION BASED ON A TRAFFIC LIGHT CONCEPT

    OpenAIRE

    Drayer, Elisabeth; Hegemann, Jan; Lazarus, Marc; Caire, Raphael; Braun, Martin

    2015-01-01

    Compared to a centralised grid operation management for the distribution grid, a distributed and decentralised agent-based operation has a lot of advantages, like scalability, modularity and robustness. We propose the concept for an agent-based distribution grid operation management based on a traffic light concept. Depending on the situation in the grid, the operation management can be in different modes, which define the way how the grid is operated.

  19. On infrastructure network design with agent-based modelling

    OpenAIRE

    Chappin, E.J.L.; Heijnen, P.W.

    2014-01-01

    We have developed an agent-based model to optimize green-field network design in an industrial area. We aim to capture some of the deep uncertainties surrounding infrastructure design by modelling it developing specific ant colony optimizations. Hence, we propose a variety of extensions to our existing work, first ideas on how to realize them and three cases to explicate our ideas. One case is the design of a CO2 pipeline network in Rotterdam industrial area. First simulation results have sho...

  20. Ontology-based, multi-agent support of production management

    Science.gov (United States)

    Meridou, Despina T.; Inden, Udo; Rückemann, Claus-Peter; Patrikakis, Charalampos Z.; Kaklamani, Dimitra-Theodora I.; Venieris, Iakovos S.

    2016-06-01

    Over the recent years, the reported incidents on failed aircraft ramp-ups or the delayed production in small-lots have increased substantially. In this paper, we present a production management platform that combines agent-based techniques with the Service Oriented Architecture paradigm. This platform takes advantage of the functionality offered by the semantic web language OWL, which allows the users and services of the platform to speak a common language and, at the same time, facilitates risk management and decision making.

  1. Metathesis access to monocyclic iminocyclitol-based therapeutic agents

    Directory of Open Access Journals (Sweden)

    Albert Demonceau

    2011-05-01

    Full Text Available By focusing on recent developments on natural and non-natural azasugars (iminocyclitols, this review bolsters the case for the role of olefin metathesis reactions (RCM, CM as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted.

  2. Agent-based simulation of electricity markets. A literature review

    Energy Technology Data Exchange (ETDEWEB)

    Sensfuss, F.; Ragwitz, M. [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany); Genoese, M.; Moest, D. [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Industriebetriebslehre und Industrielle Produktion

    2007-07-01

    Liberalisation, climate policy and promotion of renewable energy are challenges to players of the electricity sector in many countries. Policy makers have to con-sider issues like market power, bounded rationality of players and the appear-ance of fluctuating energy sources in order to provide adequate legislation. Fur-thermore the interactions between markets and environmental policy instru-ments become an issue of increasing importance. A promising approach for the scientific analysis of these developments is the field of agent-based simulation. The goal of this article is to provide an overview of the current work applying this methodology to the analysis of electricity markets. (orig.)

  3. A Novel Architecture of Agent based Crawling for OAI Resources

    OpenAIRE

    J. P. Gupta; Shruti Sharma

    2010-01-01

    Nowadays, most of the search engines are competing to index as much of the Surface Web as possible with leaving a lurch at the OAI content (pdf documents), which holds a huge amount of information than surface web. In this paper, a novel framework for OAI-PMH based Crawler is being proposed that uses agents to extract the metadata about the OAI resources and store them in a repository which is later on queried through the OAI-PMH layer to generate the XML pages containing the metadata. These ...

  4. Agent-based Algorithm for Spatial Distribution of Objects

    KAUST Repository

    Collier, Nathan

    2012-06-02

    In this paper we present an agent-based algorithm for the spatial distribution of objects. The algorithm is a generalization of the bubble mesh algorithm, initially created for the point insertion stage of the meshing process of the finite element method. The bubble mesh algorithm treats objects in space as bubbles, which repel and attract each other. The dynamics of each bubble are approximated by solving a series of ordinary differential equations. We present numerical results for a meshing application as well as a graph visualization application.

  5. Complexity and agent-based modelling in urban research

    DEFF Research Database (Denmark)

    Fertner, Christian

    influence on the bigger system. Traditional scientific methods or theories often tried to simplify, not accounting complex relations of actors and decision-making. The introduction of computers in simulation made new approaches in modelling, as for example agent-based modelling (ABM), possible, dealing...... with issues of complexity. Also in urban research, computer simulation is becoming popular for more and more issues, aiming at a new understanding of urban systems. The essay is based on some recent articles as well as some relevant websites. Due to the use of ABM in many scientific fields and the relevance......Urbanisation processes are results of a broad variety of actors or actor groups and their behaviour and decisions based on different experiences, knowledge, resources, values etc. The decisions done are often on a micro/individual level but resulting in macro/collective behaviour. In urban research...

  6. Naïve Bayesian Learning based Multi Agent Architecture for Telemedicine

    Directory of Open Access Journals (Sweden)

    Ei Ei Chaw

    2013-04-01

    Full Text Available Agent-based systems are one of the most vibrant and important areas of the research and development to have emerged in Information Technology in recent years. They are one of the most promising approaches for designing and implementing autonomous, intelligent and social software assistants capable of supporting human decision-making. These kinds of systems are believed to be appropriate in many aspects of the healthcare domain. As a result, there is a growing interest of researchers in the application of agent-based techniques to problems in the healthcare domain. The adoption of agent technologies and multi-agent constitutes an emerging area in bioinformatics. Multi-agent based medical diagnosis systems may improve traditionally developed medical computational systems and may also support medical staff in decision-making. In this paper, we simulate the multi agent system for cancer classification. The proposed architecture consists of service provider agents as upper layer agent, coordinator agent as middle layer agent and initial agent lowest layer agent. Coordinator agent serves as matchmaker agent that uses Naïve Bayesian learning method for obtaining general knowledge and selects the best service provider agent using matchmaking mechanism. Therefore this system can reduce the communication overhead between agents for sending messages and transferring data and can avoid sending the problem to irrelevant agents.

  7. Intelligent Agent based Flight Search and Booking System

    Directory of Open Access Journals (Sweden)

    Floyd Garvey

    2012-07-01

    Full Text Available The world globalization is widely used, and there are several definitions that may fit this one word. However the reality remains that globalization has impacted and is impacting each individual on this planet. It is defined to be greater movement of people, goods, capital and ideas due to increased economic integration, which in turn is propelled, by increased trade and investment. It is like moving towards living in a borderless world. With the reality of globalization, the travel industry has benefited significantly. It could be said that globalization is benefiting from the flight industry. Regardless of the way one looks at it, more persons are traveling each day and are exploring several places that were distant places on a map. Equally, technology has been growing at an increasingly rapid pace and is being utilized by several persons all over the world. With the combination of globalization and the increase in technology and the frequency in travel there is a need to provide an intelligent application that is capable to meeting the needs of travelers that utilize mobile phones all over. It is a solution that fits in perfectly to a user’s busy lifestyle, offers ease of use and enough intelligence that makes a user’s experience worthwhile. Having recognized this need, the Agent based Mobile Airline Search and Booking System is been developed that is built to work on the Android to perform Airline Search and booking using Biometric. The system also possess agent learning capability to perform the search of Airlines based on some previous search pattern .The development been carried out using JADE-LEAP Agent development kit on Android.

  8. The binding of the radioprotective agent cysteamine with the phospholipidic membrane headgroup-interface region

    International Nuclear Information System (INIS)

    The interaction of the aminothiol radioprotector cysteamine (β-mercaptoethylamine)(CYST) with dipalmitoylphosphatidylcholine (DPPC) artificial membranes has been studied by differential scanning calorimetry (DSC), turbidimetry and spin labeling. This hydrophilic molecule displays a biphasic, concentration-dependent binding to the phospholipidic head groups at neutral pH. In the CYST/DPPC molar ratio 1:160-1:2 (mole/mole) an increasing ordering effect is observed. At high concentrations (over 3:1 ratio), this ordering effect decreases. With the symmetric disulfide dimer cystamine, the biphasic effect is not shown and the membrane rigidity decrease is obtained only at concentration ratio higher than 1:1. The charge repartition of the cysteamine molecule has been shown to be disymmetric, +0.52 e on the NH3 group and +0.19 e on the SH extremity, whereas the cystamine molecule is electrostatically symmetrical. These properties could be related to their membrane effects. With cysteamine, at a low concentration, an electrostatic bridging between the negatively charged phosphate groups of the polar heads induces the increase in membrane stability: the molecules behave like a divalent cation. At high concentration a displacement of the slightly charged SH extremity by the amine disrupts the bridges and induces the decrease in rigidity: the drug behaves like a monovalent cation. Due to its symmetric charge and its double length, such an effect is not observed with cystamine. This study could bring further information about the interactions between cysteamine and polyelectrolytic structures (ADN for example) and about the radioprotective properties of this drug. (author)

  9. A novel alignment repulsion algorithm for flocking of multi-agent systems based on the number of neighbours per agent

    Science.gov (United States)

    Kahani, R.; Sedigh, A. K.; Mahjani, M. Gh.

    2015-12-01

    In this paper, an energy-based control methodology is proposed to satisfy the Reynolds three rules in a flock of multiple agents. First, a control law is provided that is directly derived from the passivity theorem. In the next step, the Number of Neighbours Alignment/Repulsion algorithm is introduced for a flock of agents which loses the cohesion ability and uniformly joint connectivity condition. With this method, each agent tries to follow the agents which escape its neighbourhood by considering the velocity of escape time and number of neighbours. It is mathematically proved that the motion of multiple agents converges to a rigid and uncrowded flock if the group is jointly connected just for an instant. Moreover, the conditions for collision avoidance are guaranteed during the entire process. Finally, simulation results are presented to show the effectiveness of the proposed methodology.

  10. An Agent Based Modelling Approach for Multi-Stakeholder Analysis of City Logistics Solutions

    OpenAIRE

    Anand, N

    2015-01-01

    This thesis presents a comprehensive framework for multi-stakeholder analysis of city logistics solutions using agent based modeling. The framework describes different stages for the systematic development of an agent based model for the city logistics domain. The framework includes a multi-perspective city logistics ontology and its validation, the development of an agent base model using this ontology, and a validation approach for the agent based model using a participatory simulation game.

  11. Effects of Starch-Based Anti-Caking Agents on Browning of Shredded Mozzarella Cheese

    OpenAIRE

    Penn, Stephanie Ann

    2003-01-01

    The effects of starch-based anti-caking agents on the browning of Mozzarella cheese were evaluated in this experiment. Six commercially available anti-caking agent treatments were examined and color measurements indicated that the starch-based anti-caking agents produced a baked cheese with a greater degree of browning than the samples treated with cellulose based anti-caking agents or no treatment (control). The cellulose-based treatments and the control also had a significantly greater mo...

  12. Agent-based and individual-based modeling a practical introduction

    CERN Document Server

    Railsback, Steven F

    2011-01-01

    Agent-based modeling is a new technique for understanding how the dynamics of biological, social, and other complex systems arise from the characteristics and behaviors of the agents making up these systems. This innovative textbook gives students and scientists the skills to design, implement, and analyze agent-based models. It starts with the fundamentals of modeling and provides an introduction to NetLogo, an easy-to-use, free, and powerful software platform. Nine chapters then each introduce an important modeling concept and show how to implement it using NetLogo. The book goes on to pres

  13. Agent-Based Deterministic Modeling of the Bone Marrow Homeostasis.

    Science.gov (United States)

    Kurhekar, Manish; Deshpande, Umesh

    2016-01-01

    Modeling of stem cells not only describes but also predicts how a stem cell's environment can control its fate. The first stem cell populations discovered were hematopoietic stem cells (HSCs). In this paper, we present a deterministic model of bone marrow (that hosts HSCs) that is consistent with several of the qualitative biological observations. This model incorporates stem cell death (apoptosis) after a certain number of cell divisions and also demonstrates that a single HSC can potentially populate the entire bone marrow. It also demonstrates that there is a production of sufficient number of differentiated cells (RBCs, WBCs, etc.). We prove that our model of bone marrow is biologically consistent and it overcomes the biological feasibility limitations of previously reported models. The major contribution of our model is the flexibility it allows in choosing model parameters which permits several different simulations to be carried out in silico without affecting the homeostatic properties of the model. We have also performed agent-based simulation of the model of bone marrow system proposed in this paper. We have also included parameter details and the results obtained from the simulation. The program of the agent-based simulation of the proposed model is made available on a publicly accessible website. PMID:27340402

  14. Agent-based Modelling, a new kind of research

    DEFF Research Database (Denmark)

    Held, Fabian P.; Wilkinson, Ian F.; Marks, Robert E.;

    2014-01-01

    We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical gu...... development. The main goal of this paper was to make research on complex social systems more accessible and help anticipate and structure the research process. © 2014 Australian and New Zealand Marketing Academy.......We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical...... guidelines to help plan and structure the development of a theory about the causes of such a phenomenon in conjunction with a matching ABM. We argue that research about complex social phenomena is still largely fundamental research and therefore an iterative and cyclical development process of both theory...

  15. LEARNING REPOSITORY ADAPTABILITY IN AN AGENT-BASED UNIVERSITY ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Vanco Cabukovski

    2016-06-01

    Full Text Available Automated e-Learning Systems (AeLS are fundamental to contemporary educational concepts worldwide.It has become a standard not only in support to the formal curriculum, but containing social platform capabilities, gamification elements and functionalities fostering communities of experts, also for faster knowledge dissemination. Additionally, AeLSs support internal communications and customizable analytics and methodologies to quickly identify learning performance, which in turn can be used as feedback to implement adaptability in tailoring the content management to meet specific individual needs. The volume of fast growing AeLS content of supplement material and exchanged communication combined with the already huge material archived in the university libraries is enormous and needs sophisticated managing through electronic repositories. Such integration of content management systems (CMS present challenges which can be solved optimally with the use of distributed management implemented through agent-based systems. This paper depicts a successful implementation of an Integrated Intelligent Agent Based UniversityInformation System (IABUIS.

  16. Operation and control interfaces based upon distributed agent networks

    International Nuclear Information System (INIS)

    The majority of todays large scale compute clusters and software systems running on them are using operation and control interfaces (OCI) for monitoring and control. The majority of these OCI's are still based upon single node applications, which are limited by the physical system they are running on. In areas where hundred thousand and more statistical values have to be analyzed and taken into account for visualization and decision making this kind of OCI's are no option at all. Furthermore, this kind of OCI's do not empower whole collaborations to control and operate cluster at the same time from around the world. Distributed agent networks (DAN) tend to have the possibility to overcome this limitations. A distributed agent network is per design a multi-node approach. Together with a web based OCI, automatic data propagation and distributed locking algorithms they provide simultaneous operation and control, distributed state tracking and visualization to world wide collaborations. The first compute cluster in the scientific world using this combination of technologies is the ALICE HLT at CERN.

  17. An agent-based approach to financial stylized facts

    Science.gov (United States)

    Shimokawa, Tetsuya; Suzuki, Kyoko; Misawa, Tadanobu

    2007-06-01

    An important challenge of the financial theory in recent years is to construct more sophisticated models which have consistencies with as many financial stylized facts that cannot be explained by traditional models. Recently, psychological studies on decision making under uncertainty which originate in Kahneman and Tversky's research attract a lot of interest as key factors which figure out the financial stylized facts. These psychological results have been applied to the theory of investor's decision making and financial equilibrium modeling. This paper, following these behavioral financial studies, would like to propose an agent-based equilibrium model with prospect theoretical features of investors. Our goal is to point out a possibility that loss-averse feature of investors explains vast number of financial stylized facts and plays a crucial role in price formations of financial markets. Price process which is endogenously generated through our model has consistencies with, not only the equity premium puzzle and the volatility puzzle, but great kurtosis, asymmetry of return distribution, auto-correlation of return volatility, cross-correlation between return volatility and trading volume. Moreover, by using agent-based simulations, the paper also provides a rigorous explanation from the viewpoint of a lack of market liquidity to the size effect, which means that small-sized stocks enjoy excess returns compared to large-sized stocks.

  18. Router Agent Technology for Policy-Based Network Management

    Science.gov (United States)

    Chow, Edward T.; Sudhir, Gurusham; Chang, Hsin-Ping; James, Mark; Liu, Yih-Chiao J.; Chiang, Winston

    2011-01-01

    This innovation can be run as a standalone network application on any computer in a networked environment. This design can be configured to control one or more routers (one instance per router), and can also be configured to listen to a policy server over the network to receive new policies based on the policy- based network management technology. The Router Agent Technology transforms the received policies into suitable Access Control List syntax for the routers it is configured to control. It commits the newly generated access control lists to the routers and provides feedback regarding any errors that were faced. The innovation also automatically generates a time-stamped log file regarding all updates to the router it is configured to control. This technology, once installed on a local network computer and started, is autonomous because it has the capability to keep listening to new policies from the policy server, transforming those policies to router-compliant access lists, and committing those access lists to a specified interface on the specified router on the network with any error feedback regarding commitment process. The stand-alone application is named RouterAgent and is currently realized as a fully functional (version 1) implementation for the Windows operating system and for CISCO routers.

  19. Neutron transport benchmark examples with web-based AGENT

    International Nuclear Information System (INIS)

    The AGENT (Arbitrary GEometry Neutron Transport) an open-architecture reactor modeling tool is deterministic neutron transport code for two- or three-dimensional heterogeneous neutronic design and analysis of the whole reactor cores regardless of geometry types and material configurations. The AGENT neutron transport methodology is applicable to all generations of nuclear power and research reactors. It combines three theories: (1) mathematical theory of R-functions that is used to generate real three-dimensional geometries of square or hexagonal heterogeneous geometries, (2) the x-y method of characteristics (MOC) used to solve isotropic neutron transport in non-homogenized 2D reactor slices, and (3) the one-dimensional diffusion theory or MOC theory used to couple the x-y and z neutron tracks through the transverse leakage and angular mesh-wise flux values. The R-function geometrical module allows a sequential building of the layers of geometry and automatic submeshing based on the network of geometric domain functions. The simplicity of geometry description and selection of parameters for accurate treatment of neutron propagation is achieved through the Boolean algebraic hierarchically organized simple primitives into complex domains (both being represented with corresponding domain functions). AGENT methodologies and numerical solutions are applicable in validating neutronic analysis for GenIV reactor designs while the effect of double heterogeneity in very high temperature reactors (VHTRs) is under development. The accuracy is comparable to Monte Carlo codes and is obtained by following neutron propagation through real geometrical domains that does not require homogenization or simplifications. The efficiency is maintained through set of acceleration techniques introduced at all important calculation levels. The flux solution incorporates power iteration with two different acceleration techniques: coarse mesh rebalancing (CMR) and coarse mesh finite difference

  20. Empirical agent-based land market: Integrating adaptive economic behavior in urban land-use models

    NARCIS (Netherlands)

    Filatova, Tatiana

    2015-01-01

    This paper introduces an economic agent-based model of an urban housing market. The RHEA (Risks and Hedonics in Empirical Agent-based land market) model captures natural hazard risks and environmental amenities through hedonic analysis, facilitating empirical agent-based land market modeling. RHEA i

  1. DCE-MRI using small-molecular and albumin-binding contrast agents in experimental carcinomas with different stromal content

    Energy Technology Data Exchange (ETDEWEB)

    Farace, Paolo; Merigo, Flavia; Fiorini, Silvia; Nicolato, Elena; Tambalo, Stefano; Daducci, Alessandro [Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Verona (Italy); Degrassi, Anna [Nerviano Medical Sciences Institute, Milan (Italy); Sbarbati, Andrea [Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Verona (Italy); Rubello, Domenico, E-mail: domenico.rubello@libero.it [Department of Radiology, Nuclear Medicine, Medical Physics, Services of Radiology and Nuclear Medicine, ' S. Maria della Misericordia' Hospital, Viale Tre Martiri 140, 45100 Rovigo (Italy); Marzola, Pasquina [Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Verona (Italy)

    2011-04-15

    Objectives: To compare DCE-MRI experiments performed using a standard small-molecular (Gd-DTPA) and an albumin-binding (MS-325) contrast agent in two carcinoma models with different stromal content. Materials and methods: DU-145 or BXPC-3 cancer cells were subcutaneously injected into nude mice. DCE-MRI was performed by a bolus injection of Gd-DTPA or MS-325 about 2 weeks after inoculation. For quantitative analysis a volume of interest was manually drawn over each tumor. To address the heterogeneous enhancement, each tumor volume was then divided into the 20% most-enhancing and the remaining 80% least-enhancing fractions. Mean tumor enhancement was calculated over these selected tumor volumes and compared between tumor groups and contrast agents. Maps of differential enhancement, peak enhancement and time-to-peak were used for visual evaluation. CD31 and VEGF immunohistochemistry were performed in excised tumors. Results: In the 80% least-enhancing volume, at late time points of the dynamic scan, the mean enhancement elicited by MS-325 was higher in BXPC-3 than in DU-145 tumors. In the 20% most-enhancing volume, using either contrast agents, significant difference between the two tumors types were observed only early, while at later time points of the dynamic scan the difference were obscured by the faster washout observed in the BXPC-3 tumors. Enhancement maps confirmed that BXPC-3 tumors were characterized by marked washout rate using either contrast agent, particularly in the higher enhancing peripheral rim. With MS-325 this washout pattern appeared to be specific to the BXPC-3 carcinomas, since it was not observed in the DU-145 tumors. Finally, in both tumor types, MS-325 produced significantly higher enhancement than Gd-DTPA in the late phase of the dynamic scan. Ex vivo analysis confirmed the marked presence of aberrant infiltrative stroma in BXPC-3 tumors, in which tumor vessels were embedded. In all tumors the central portion was less viable and less

  2. Agent-based multi-optional model of innovations diffusion

    CERN Document Server

    Laciana, Carlos E

    2013-01-01

    We propose a formalism that allows the study of the process of diffusion of several products competing in a common market. It is based on the generalization of the statistics Ising model (Potts model). For the implementation, agent based modeling is used, applied to a problem of three options; to adopt a product A, a product B, or non-adoption. A launching strategy is analyzed for one of the two products, which delays its launching with the objective of competing with improvements. The proportion reached by one and another product is calculated at market saturation. The simulations are produced varying the social network topology, the uncertainty in the decision, and the population's homogeneity.

  3. Using Agent Based Modeling (ABM) to Develop Cultural Interaction Simulations

    Science.gov (United States)

    Drucker, Nick; Jones, Phillip N.

    2012-01-01

    Today, most cultural training is based on or built around "cultural engagements" or discrete interactions between the individual learner and one or more cultural "others". Often, success in the engagement is the end or the objective. In reality, these interactions usually involve secondary and tertiary effects with potentially wide ranging consequences. The concern is that learning culture within a strict engagement context might lead to "checklist" cultural thinking that will not empower learners to understand the full consequence of their actions. We propose the use of agent based modeling (ABM) to collect, store, and, simulating the effects of social networks, promulgate engagement effects over time, distance, and consequence. The ABM development allows for rapid modification to re-create any number of population types, extending the applicability of the model to any requirement for social modeling.

  4. Multispace Behavioral Model for Face-Based Affective Social Agents

    Directory of Open Access Journals (Sweden)

    DiPaola Steve

    2007-01-01

    Full Text Available This paper describes a behavioral model for affective social agents based on three independent but interacting parameter spaces: knowledge, personality, and mood. These spaces control a lower-level geometry space that provides parameters at the facial feature level. Personality and mood use findings in behavioral psychology to relate the perception of personality types and emotional states to the facial actions and expressions through two-dimensional models for personality and emotion. Knowledge encapsulates the tasks to be performed and the decision-making process using a specially designed XML-based language. While the geometry space provides an MPEG-4 compatible set of parameters for low-level control, the behavioral extensions available through the triple spaces provide flexible means of designing complicated personality types, facial expression, and dynamic interactive scenarios.

  5. Multispace Behavioral Model for Face-Based Affective Social Agents

    Directory of Open Access Journals (Sweden)

    Ali Arya

    2007-03-01

    Full Text Available This paper describes a behavioral model for affective social agents based on three independent but interacting parameter spaces: knowledge, personality, and mood. These spaces control a lower-level geometry space that provides parameters at the facial feature level. Personality and mood use findings in behavioral psychology to relate the perception of personality types and emotional states to the facial actions and expressions through two-dimensional models for personality and emotion. Knowledge encapsulates the tasks to be performed and the decision-making process using a specially designed XML-based language. While the geometry space provides an MPEG-4 compatible set of parameters for low-level control, the behavioral extensions available through the triple spaces provide flexible means of designing complicated personality types, facial expression, and dynamic interactive scenarios.

  6. Stable optical trapping based on optical binding forces.

    Science.gov (United States)

    Grzegorczyk, Tomasz M; Kemp, Brandon A; Kong, Jin Au

    2006-03-24

    Various trapping configurations have been realized so far, either based on the scattering force or the gradient force. In this Letter, we propose a new trapping regime based on the equilibrium between a scattering force and optical binding forces only. The trap is realized from the interaction between a single plane wave and a series of fixed small particles, and is efficient at trapping multiple free particles. The effects are demonstrated analytically upon computing the exact scattering from a collection of cylindrical particles and calculating the Lorentz force on each free particle via the Maxwell stress tensor. PMID:16605823

  7. Modeling and simulation of complex systems a framework for efficient agent-based modeling and simulation

    CERN Document Server

    Siegfried, Robert

    2014-01-01

    Robert Siegfried presents a framework for efficient agent-based modeling and simulation of complex systems. He compares different approaches for describing structure and dynamics of agent-based models in detail. Based on this evaluation the author introduces the "General Reference Model for Agent-based Modeling and Simulation" (GRAMS). Furthermore he presents parallel and distributed simulation approaches for execution of agent-based models -from small scale to very large scale. The author shows how agent-based models may be executed by different simulation engines that utilize underlying hard

  8. Multi-agent based modeling for electric vehicle integration in a distribution network operation

    DEFF Research Database (Denmark)

    Hu, Junjie; Morais, Hugo; Lind, Morten;

    2016-01-01

    The purpose of this paper is to present a multi-agent based modeling technology for simulating and operating a hierarchical energy management of a power distribution system with focus on EVs integration. The proposed multi-agent system consists of four types of agents: i) Distribution system...... of the proposed system, a multi-agent simulation platform is developed based on the co-simulation environment of JACK, Matlab and GAMS. The aim of the multi-agent system is to simulate the collaborative (all agents contribute to achieve an optimized global performance) but also competitive environment (each agent...... operator (DSO) technical agent and ii) DSO market agents that both belong to the top layer of the hierarchy and their roles are to manage the distribution network by avoiding grid congestions and using congestion prices to coordinate the energy scheduled; iii) Electric vehicle virtual power plant agents...

  9. Frequency-Based Patrolling with Heterogeneous Agents and Limited Communication

    OpenAIRE

    Mao, Tao; Ray, Laura

    2014-01-01

    This paper investigates multi-agent frequencybased patrolling of intersecting, circle graphs under conditions where graph nodes have non-uniform visitation requirements and agents have limited ability to communicate. The task is modeled as a partially observable Markov decision process, and a reinforcement learning solution is developed. Each agent generates its own policy from Markov chains, and policies are exchanged only when agents occupy the same or adjacent nodes. This constraint on pol...

  10. Measure of Landscape Heterogeneity by Agent-Based Methodology

    Science.gov (United States)

    Wirth, E.; Szabó, Gy.; Czinkóczky, A.

    2016-06-01

    With the rapid increase of the world's population, the efficient food production is one of the key factors of the human survival. Since biodiversity and heterogeneity is the basis of the sustainable agriculture, the authors tried to measure the heterogeneity of a chosen landscape. The EU farming and subsidizing policies (EEA, 2014) support landscape heterogeneity and diversity, nevertheless exact measurements and calculations apart from statistical parameters (standard deviation, mean), do not really exist. In the present paper the authors' goal is to find an objective, dynamic method that measures landscape heterogeneity. It is achieved with the so called agent-based modelling, where randomly dispatched dynamic scouts record the observed land cover parameters and sum up the features of a new type of land. During the simulation the agents collect a Monte Carlo integral as a diversity landscape potential which can be considered as the unit of the `greening' measure. As a final product of the ABM method, a landscape potential map is obtained that can serve as a tool for objective decision making to support agricultural diversity.

  11. Agent-based Market Research Learning Environment for New Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Alejandro Valencia

    2012-01-01

    Full Text Available Due to the importance of creating alternative mechanisms to generate know-how on potential markets for new entrepreneurs this paper proposes an agent-based learning environment to help them learning market research strategies within new businesses. An instructor agent, serving as a learning assistant within the MAS environment guides new entrepreneurs to identify their most adequate market niche. The integration of MAS-CommonKADS and GAIA methodologies is used along with AUML diagrams in order to design and develop this agentbased learning environment, called MaREMAS. The paper thus describes all the stages concerning MaREMAS construction focusing on the conceptualization, analysis, design, prototype development, and validation. The tests developed in the MaREMAS learning environment were satisfactory, however, it is proposed as future work to provide the system a more robust statistical module that allows a better analysis of the research variables and hence be able to generate more useful suggestions to the entrepreneur.

  12. An agent-based model for energy service companies

    International Nuclear Information System (INIS)

    Highlights: • An agent-based model for household energy efficiency upgrades is considered. • Energy service companies provide an alternative to traditional utility providers. • Household self-financing is a limiting factor to widespread efficiency upgrading. • Longer term service contracts can lead to reduced household energy costs. • Future energy price increases enable service providers to retain their customer base. - Abstract: The residential housing sector is a major consumer of energy accounting for approximately one third of carbon emissions in the United Kingdom. Achieving a sustainable, low-carbon infrastructure necessitates a reduced and more efficient use of domestic energy supplies. Energy service companies offer an alternative to traditional providers, which supply a single utility product to satisfy the unconstrained demand of end users, and have been identified as a potentially important actor in sustainable future economies. An agent-based model is developed to examine the potential of energy service companies to contribute to the large scale upgrading of household energy efficiency, which would ultimately lead to a more sustainable and secure energy infrastructure. The migration of households towards energy service companies is described by an attractiveness array, through which potential customers can evaluate the future benefits, in terms of household energy costs, of changing provider. It is shown that self-financing is a limiting factor to the widespread upgrading of residential energy efficiency. Greater reductions in household energy costs could be achieved by committing to longer term contracts, allowing upgrade costs to be distributed over greater time intervals. A steadily increasing cost of future energy usage lends an element of stability to the market, with energy service companies displaying the ability to retain customers on contract expiration. The model highlights how a greater focus on the provision of energy services, as

  13. Distributed Research Project Scheduling Based on Multi-Agent Methods

    Directory of Open Access Journals (Sweden)

    Constanta Nicoleta Bodea

    2011-01-01

    Full Text Available Different project planning and scheduling approaches have been developed. The Operational Research (OR provides two major planning techniques: CPM (Critical Path Method and PERT (Program Evaluation and Review Technique. Due to projects complexity and difficulty to use classical methods, new approaches were developed. Artificial Intelligence (AI initially promoted the automatic planner concept, but model-based planning and scheduling methods emerged later on. The paper adresses the project scheduling optimization problem, when projects are seen as Complex Adaptive Systems (CAS. Taken into consideration two different approaches for project scheduling optimization: TCPSP (Time- Constrained Project Scheduling and RCPSP (Resource-Constrained Project Scheduling, the paper focuses on a multiagent implementation in MATLAB for TCSP. Using the research project as a case study, the paper includes a comparison between two multi-agent methods: Genetic Algorithm (GA and Ant Colony Algorithm (ACO.

  14. Survey of the agent-based approach to intelligent manufacturing

    Directory of Open Access Journals (Sweden)

    J. Madejski

    2007-03-01

    Full Text Available Purpose: Summary of the state-of-the-art of the Distributed Artificial Intelligence applied to Intelligent Manufacturing. Main applications are presented along with different technologies applied in these areas.Design/methodology/approach: Intelligent Manufacturing area was split into many segments, which require different approach to intelligent problem solving. Multiagent systems negotiation needs were analysed and cooperation issues in the form of clustering, cloning, and learning were analysed in search for the relevant tools.Findings: Detailed review of the approach to development of the agent based Intelligent Manufacturing from the fundamental considerations to the latest hands-on developments.Research limitations/implications: Many presented technologies call for detailed study before they can be implemented in practice.Originality/value: Thorough review of the Distributed Artificial Intelligence approach to current agile manufacturing needs. Key technologies are pointed out along with the main areas in which they can be implemented, and which require further research.

  15. UML-Based Design and Validation of Intelligent Agents-Based Reconfigurable Embedded Control Systems

    OpenAIRE

    Amen Ben Hadj Ali; Mohamed Khalgui; Samir Ben Ahmed

    2012-01-01

    The paper examines UML-based design and validation of reconfigurable embedded control systems which can have multiple software architectural configurations such that each one is designed by a set of inter-connected software components. To handle dynamic reconfiguration scenarios, the authors define a software agent which interacts with users and applies several forms of reconfiguration at different granularity levels of the system’s architecture. The agent has the ability of monitoring the ...

  16. Currency-based Iterative Multi-Agent Bidding Mechanism Based on Genetic Algorithm

    Institute of Scientific and Technical Information of China (English)

    M; K; LIM; Z; ZHANG

    2002-01-01

    This paper introduces a multi-agent system which i nt egrates process planning and production scheduling, in order to increase the fle xibility of manufacturing systems in coping with rapid changes in dynamic market and dealing with internal uncertainties such as machine breakdown or resources shortage. This system consists of various autonomous agents, each of which has t he capability of communicating with one another and making decisions based on it s knowledge and if necessary on information provided ...

  17. A Systematic Review of Agent-Based Modelling and Simulation Applications in the Higher Education Domain

    Science.gov (United States)

    Gu, X.; Blackmore, K. L.

    2015-01-01

    This paper presents the results of a systematic review of agent-based modelling and simulation (ABMS) applications in the higher education (HE) domain. Agent-based modelling is a "bottom-up" modelling paradigm in which system-level behaviour (macro) is modelled through the behaviour of individual local-level agent interactions (micro).…

  18. The Impact of a Peer-Learning Agent Based on Pair Programming in a Programming Course

    Science.gov (United States)

    Han, Keun-Woo; Lee, EunKyoung; Lee, YoungJun

    2010-01-01

    This paper analyzes the educational effects of a peer-learning agent based on pair programming in programming courses. A peer-learning agent system was developed to facilitate the learning of a programming language through the use of pair programming strategies. This system is based on the role of a peer-learning agent from pedagogical and…

  19. Multi-agent reinforcement learning with cooperation based on eligibility traces

    Institute of Scientific and Technical Information of China (English)

    杨玉君; 程君实; 陈佳品

    2004-01-01

    The application of reinforcement learning is widely used by multi-agent systems in recent years. An agent uses a multi-agent system to cooperate with other agents to accomplish the given task, and one agent's be-havior usually affects the others' behaviors. In traditional reinforcement learning, one agent takes the others lo-cation, so it is difficult to consider the others' behavior, which decreases the learning efficiency. This paper proposes multi-agent reinforcement learning with cooperation based on eligibility traces, i.e. one agent esti-mates the other agent's behavior with the other agent's eligibility traces. The results of this simulation prove the validity of the proposed learning method.

  20. Design on PKI-Based Anonymous Mobile Agent Security in E-Commerce

    Institute of Scientific and Technical Information of China (English)

    MENG Xiangsong; HAN Fengwu

    2006-01-01

    The security of mobile agent directly decides its usage width in e-commerce. Especially, to protect users' private information is becoming more important now and future. So an anonymous mobile agent security mechanism with the secure authentication infrastructure based on PKI(public key infrastructure) is proposed in the paper. The multi-agent system is programmed by java language and every agent must register itself in CA(certificate authority) before working in the net and express his legit identity which is temptly produced and used only once. The CA ensures the legal of all agents' identity which take part in communicaiton or trade. And every user agent identity only is used once which makes other agents cannot decipher users' private information. The security mechanism of the multi-agent system implements anonymity, integrity, data confidentiality of mobile agent based on the MH(multiple hop) integrity protection regard to PKI limit.

  1. A Transport Model of Mobile Agent Based on Secure Hybrid Encryption

    Institute of Scientific and Technical Information of China (English)

    SUNZhixin; CHENZhixian; WANGRuchuan

    2005-01-01

    The solution of security problems of mobile agents is a key issue, which will decide whether mobile agents can be widely used. The paper analyzes main security problems, which currently are confronted with mobile agent systems and existing protection solutions. And then the paper presents a Security Transport model of mobile agents based on a hybrid encryption algorithm (TMSHE).Meanwhile, it expatiates on implementation of the algorithm. The algorithm of TMSHE model mainly consists of two parts, i.e., employing a hybrid encryption algorithm to encrypt mobile agents and using Transport layer security (TLS) to encrypt communication channel. Mobile agents by hybrid encryption move through communication channels, which are encrypted by TLS. The simulation results indicate that the model can protect mobile agents' security effectively, and consequently the security and steadiness of the whole mobile agent system are also improved. The model has succeeded in getting application in a prototypesystem- Intrusion detection system based on mobile agents.

  2. Smart Agent Based Mobile Tutoring and Querying System

    Directory of Open Access Journals (Sweden)

    Suresh Sankaranarayanan

    2012-08-01

    Full Text Available With our busy schedules today and the rising cost of education there is a need to find a convenient and cost effective means of maximizing our educational/training experiences. New trends in the delivery/access of information are becoming more technology based in all areas of society with education being no exception. The ubiquitous use of mobile devices has led to a boom in m-commerce. Mobile devices provide many services in commercial environments such as mobile banking, mobile purchasing, mobile learning, etc. It is therefore fitting that we seek to use mobile devices as a platform in delivering our convenient and cost effective solution. The proposed agent based Mobile tutoring system seeks to provide a student with a rich learning experience that will provide them with the relevant reading material based on their stage of development which allows them to move at their own pace. The system will allow the user to be able to ask certain questions and get explanations as if they were interacting with a human tutor but with the added benefit of being able to do this anytime in any location via their mobile phone.

  3. Enhancing Multi-Agent Based Simulation with Human-Agents Interactive Spatial Behaviour

    CERN Document Server

    Chen, Yee Ming; Shiu, Hung-Ming

    2009-01-01

    We are exploring the enhancement of models of agent behaviour with more "human-like" decision making strategies than are presently available. Our motivation is to developed with a view to as the decision analysis and support for electric taxi company under the mission of energy saving and reduction of CO2, in particular car-pool and car-sharing management policies. In order to achieve the object of decision analysis for user, we provide a human-agents interactive spatial behaviour to support user making decision real time. We adopt passenger average waiting time and electric taxi average idle time as the performance measures and decision support fro electric taxi company. Finally, according to the analysis result, we demonstrate that our multi-agent simulation and GUI can help users or companies quickly make a quality and accurate decision to reduce the decision-making cost and time.

  4. Agent-based simulation of military operations other than war small unit combat

    OpenAIRE

    Woodaman, Ronald F. A.

    2000-01-01

    A significant challenge to the Armed Forces today is the development of tactics, techniques, procedures, and equipment that will enable success in the small-scale combats that characterize Military Operations Other Than War (MOOTW). This thesis develops an agent-based simulation methodology for modeling MOOTW combat scenarios. The methodology combines agent-based modeling with discrete event simulation in a software package called AgentKit. AgentKit is used to model a riot control problem for...

  5. AN AGENT BASED TRANSACTION PROCESSING SCHEME FOR DISCONNECTED MOBILE NODES

    Directory of Open Access Journals (Sweden)

    J.L. Walter Jeyakumar

    2010-12-01

    Full Text Available We present a mobile transaction framework in which mobile users can share data which is stored in the cache of a mobile agent. This mobile agent is a special mobile node which coordinates the sharing process. The proposed framework allows mobile affiliation work groups to be formed dynamically with a mobile agent and mobile hosts. Using short range wireless communication technology, mobile users can simultaneously access the data from the cache of the mobile agent. The data Access Manager module at the mobile agent enforces concurrency control using cache invalidation technique. This model supports disconnected mobile computing allowing mobile agent to move along with the Mobile Hosts. The proposed Transaction frame work has been simulated in Java 2 and performance of this scheme is compared with existing frame works.

  6. Agent-Based Modeling of Consumer Decision making Process Based on Power Distance and Personality

    NARCIS (Netherlands)

    Roozmand, O.; Ghasem-Aghaee, N.; Hofstede, G.J.; Nematbakhsh, M.A.; Baraani, A.; Verwaart, T.

    2011-01-01

    Simulating consumer decision making processes involves different disciplines such as: sociology, social psychology, marketing, and computer science. In this paper, we propose an agent-based conceptual and computational model of consumer decision-making based on culture, personality and human needs.

  7. Serious games experiment toward agent-based simulation

    Science.gov (United States)

    Wein, Anne; Labiosa, William

    2013-01-01

    We evaluate the potential for serious games to be used as a scientifically based decision-support product that supports the United States Geological Survey’s (USGS) mission--to provide integrated, unbiased scientific information that can make a substantial contribution to societal well-being for a wide variety of complex environmental challenges. Serious or pedagogical games are an engaging way to educate decisionmakers and stakeholders about environmental challenges that are usefully informed by natural and social scientific information and knowledge and can be designed to promote interactive learning and exploration in the face of large uncertainties, divergent values, and complex situations. We developed two serious games that use challenging environmental-planning issues to demonstrate and investigate the potential contributions of serious games to inform regional-planning decisions. Delta Skelta is a game emulating long-term integrated environmental planning in the Sacramento-San Joaquin Delta, California, that incorporates natural hazards (flooding and earthquakes) and consequences for California water supplies amidst conflicting water interests. Age of Ecology is a game that simulates interactions between economic and ecologic processes, as well as natural hazards while implementing agent-based modeling. The content of these games spans the USGS science mission areas related to water, ecosystems, natural hazards, land use, and climate change. We describe the games, reflect on design and informational aspects, and comment on their potential usefulness. During the process of developing these games, we identified various design trade-offs involving factual information, strategic thinking, game-winning criteria, elements of fun, number and type of players, time horizon, and uncertainty. We evaluate the two games in terms of accomplishments and limitations. Overall, we demonstrated the potential for these games to usefully represent scientific information

  8. Agent-based mapping of credit risk for sustainable microfinance.

    Science.gov (United States)

    Lee, Joung-Hun; Jusup, Marko; Podobnik, Boris; Iwasa, Yoh

    2015-01-01

    By drawing analogies with independent research areas, we propose an unorthodox framework for mapping microfinance credit risk--a major obstacle to the sustainability of lenders outreaching to the poor. Specifically, using the elements of network theory, we constructed an agent-based model that obeys the stylized rules of microfinance industry. We found that in a deteriorating economic environment confounded with adverse selection, a form of latent moral hazard may cause a regime shift from a high to a low loan payment probability. An after-the-fact recovery, when possible, required the economic environment to improve beyond that which led to the shift in the first place. These findings suggest a small set of measurable quantities for mapping microfinance credit risk and, consequently, for balancing the requirements to reasonably price loans and to operate on a fully self-financed basis. We illustrate how the proposed mapping works using a 10-year monthly data set from one of the best-known microfinance representatives, Grameen Bank in Bangladesh. Finally, we discuss an entirely new perspective for managing microfinance credit risk based on enticing spontaneous cooperation by building social capital. PMID:25945790

  9. Agent-based mapping of credit risk for sustainable microfinance.

    Directory of Open Access Journals (Sweden)

    Joung-Hun Lee

    Full Text Available By drawing analogies with independent research areas, we propose an unorthodox framework for mapping microfinance credit risk--a major obstacle to the sustainability of lenders outreaching to the poor. Specifically, using the elements of network theory, we constructed an agent-based model that obeys the stylized rules of microfinance industry. We found that in a deteriorating economic environment confounded with adverse selection, a form of latent moral hazard may cause a regime shift from a high to a low loan payment probability. An after-the-fact recovery, when possible, required the economic environment to improve beyond that which led to the shift in the first place. These findings suggest a small set of measurable quantities for mapping microfinance credit risk and, consequently, for balancing the requirements to reasonably price loans and to operate on a fully self-financed basis. We illustrate how the proposed mapping works using a 10-year monthly data set from one of the best-known microfinance representatives, Grameen Bank in Bangladesh. Finally, we discuss an entirely new perspective for managing microfinance credit risk based on enticing spontaneous cooperation by building social capital.

  10. An Efficient Agent-Based AODV Routing Protocol in MANET

    Directory of Open Access Journals (Sweden)

    Preeti Bhati,

    2011-07-01

    Full Text Available A MANET (Mobile Adhoc Network consists of a collection of mobile nodes communicating with each other without any fixed infrastructure such as access points or base stations. MANETS are self organizing or self restoring. Network topology in MANETS is subject to continuous and precipitous (unpredictable change. The limited bandwidth availability, energy constraints and highly dynamic topology make the routing process as exigent. The routing process in MANET relies (based on the cooperation of individual nodes which constitute the network. In this paper, we have tried to remove the existence of misbehaving nodes that may paralyze or slows down the routing operation in MANET. This increases the efficiency of a network. Efficiency can be calculated by the parameters or factors such astransmission capacity, battery power and scalability. Here we are considering the most crucial factor named as transmission capacity of a node. In MANET, as the network size increases complexity of anetwork also increases. To overcome this we make network as modular. So the network becomes task specific which refer to a particular work only. This is the reason of infusing the concept of agents in anefficient network. This proposed protocol provides the most efficient and reliable route which may or may not be minimum hop count.

  11. Interface Agent for Computer-based Tutoring Systems.

    Science.gov (United States)

    Dang, Trang; Ghenniwa, Hamada; Kamel, Mohamed

    1999-01-01

    Proposes an interface agent for intelligent tutoring systems that creates a collaborative learning environment between the learner and the tutoring software. Describes implementation of a prototype using the IBM Agent Builder Environment Toolkit to use with an intelligent tutoring system for algebra and considers benefits in a lifelong learning…

  12. Social robotics: reality and virtuality in agent-based robotics

    OpenAIRE

    Duffy, Brian R.; Collier, Rem; O'Hare, G. M. P.; Rooney, Colm, (Thesis); O'Donoghue, Ruadhan

    1999-01-01

    This paper advocates the application of multi-agent techniques in the realisation of social robotic behaviour. We present the Social Robot Architecture, which integrates the key elements of agenthood and robotics in a coherent and systematic manner. This architecture seamlessly integrates real world robots, multi-agent development tools, and VRML visualisation tools into a coherent whole. peer-reviewed

  13. Step-coordination Algorithm of Traffic Control Based on Multi-agent System

    Institute of Scientific and Technical Information of China (English)

    Hai-Tao Zhang; Fang Yu; Wen Li

    2009-01-01

    Aiming at the deficiency of conventional traffic control method, this paper proposes a new method based on multi-agent technology for traffic control. Different from many existing methods, this paper distinguishes traffic control on the basis of the agent technology from conventional traffic control method. The composition and structure of a multi-agent system (MAS) is first discussed. Then, the step-coordination strategies of intersection-agent, segment-agent, and area-agent are put forward. The advantages of the algorithm are demonstrated by a simulation study.

  14. On the acceleration of spatially distributed agent-based computations: a patch dynamics scheme

    OpenAIRE

    Liu, Ping; Samaey, Giovanni; Gear, C. William; Kevrekidis, Ioannis G.

    2014-01-01

    In recent years, individual-based/agent-based modeling has been applied to study a wide range of applications, ranging from engineering problems to phenomena in sociology, economics and biology. Simulating such agent-based models over extended spatiotemporal domains can be prohibitively expensive due to stochasticity and the presence of multiple scales. Nevertheless, many agent-based problems exhibit smooth behavior in space and time on a macroscopic scale, suggesting that a useful coarse-gra...

  15. Mobile-C Based Agent System for Detecting Improper Computer Usage at Computer Laboratories

    OpenAIRE

    Zhixin Tie

    2013-01-01

    Mobile agent based computing is one of the powerful technologies for the development of distributed complex systems. There is little research regarding the effectiveness of mobile agent based detecting of improper computer usage at computer laboratories. This paper presents a Mobile-C Based Agent System (MCBAS) for Detecting Improper Computer Usage at Computer Laboratories. Based on the Mobile-C library, the MABAS supports the dynamic sending and executing of control command, dynamic data exc...

  16. Distributed Human Resource Redistribution System Based on Agent and Ontology

    Institute of Scientific and Technical Information of China (English)

    Li Xiangquan; Wang Ningsheng; Long Wen

    2006-01-01

    A computer system for human resource (HR) redistribution system is presented to solve the balance problem of the "surplus resources" and "surplus tasks" among a group of project units. The system architecture is designed in a compositional manner using the elements of agent technology and knowledge technology. A combination of generic agent models, ontology and knowledge provides an effective approach to address the dynamic, distributed and knowledge-intensive characters of the HR management. In the system, the broker agent acting as intermediary provides matchmaking services to the domain agents, and the individual domain agents communicate directly with each other. The HR ontology provides the semantic match of the surplus task and the surplus resource. Finally, an application example is presented to illustrate the achieved solution for a concrete scenario. This novel way offers a comprehensive HR exchange solution and is suitable for both intra-organizational and inter-organizational HR management.

  17. The "Wedding-Ring": An agent-based marriage model based on social interaction

    Directory of Open Access Journals (Sweden)

    Alexia Prskawetz

    2007-08-01

    Full Text Available In this paper we develop an agent-based marriage model based on social interaction. We build an population of interacting agents whose chances of marrying depend on the availability of partners, and whose willingness to marry depends on the share of relevant others in their social network who are already married. We then let the typical aggregate age pattern of marriage emerge from the bottom-up. The results of our simulation show that micro-level hypotheses founded on existing theory and evidence on social interaction can reproduce age-at-marriage patterns with both realistic shape and realistic micro-level dynamics.

  18. Agent-based models for higher-order theory of mind

    NARCIS (Netherlands)

    de Weerd, Harmen; Verbrugge, Rineke; Verheij, Bart; Kamiński, Bogumił; Koloch, Grzegorz

    2014-01-01

    Agent-based models are a powerful tool for explaining the emergence of social phenomena in a society. In such models, individual agents typically have little cognitive ability. In this paper, we model agents with the cognitive ability to make use of theory of mind. People use this ability to reason

  19. Pattern-oriented modeling of agent-based complex systems: lessons from ecology

    NARCIS (Netherlands)

    Grimm, V.; Revilla, E.; Berger, U.; Jeltsch, F.; Mooij, W.M.; Railsback, S.F.; Thulke, H-H.; Weiner, J.; Wiegand, T.; DeAngelis, D.L.

    2005-01-01

    Agent-based complex systems are dynamic networks of many interacting agents; examples include ecosystems, financial markets, and cities. The search for general principles underlying the internal organization of such systems often uses bottom-up simulation models such as cellular automata and agent-b

  20. Crisis response simulation combining discrete-event and agent-based modeling

    NARCIS (Netherlands)

    Gonzalez, R.A.

    2009-01-01

    This paper presents a crisis response simulation model architecture combining a discrete-event simulation (DES) environment for a crisis scenario with an agent-based model of the response organization. In multi-agent systems (MAS) as a computational organization, agents are modeled and implemented s

  1. Simulation of multi-agent manufacturing systems using agent-based modelling platforms

    OpenAIRE

    Barbosa, José; Leitão, Paulo

    2011-01-01

    Multi-agent systems (MAS) are driving the way to design and engineer control solutions that exhibit flexibility, adaptation and reconfigurability, which are important advantages over traditional centralized systems. The understanding, design and testing of such distributed agentbased approaches, and particularly those exhibiting self-* properties, are usually a hard task. Simulation assumes a crucial role to analyse the behaviour of MAS solutions during the design phase and before its deploym...

  2. RELIABILITY ANALYSIS OF RING, AGENT AND CLUSTER BASED DISTRIBUTED SYSTEMS

    Directory of Open Access Journals (Sweden)

    R.SEETHALAKSHMI

    2011-08-01

    Full Text Available The introduction of pervasive devices and mobile devices has led to immense growth of real time distributed processing. In such context reliability of the computing environment is very important. Reliability is the probability that the devices, links, processes, programs and files work efficiently for the specified period of time and in the specified condition. Distributed systems are available as conventional ring networks, clusters and agent based systems. Reliability of such systems is focused. These networks are heterogeneous and scalable in nature. There are several factors, which are to be considered for reliability estimation. These include the application related factors like algorithms, data-set sizes, memory usage pattern, input-output, communication patterns, task granularity and load-balancing. It also includes the hardware related factors like processor architecture, memory hierarchy, input-output configuration and network. The software related factors concerning reliability are operating systems, compiler, communication protocols, libraries and preprocessor performance. In estimating the reliability of a system, the performance estimation is an important aspect. Reliability analysis is approached using probability.

  3. Patient-centered appointment scheduling using agent-based simulation.

    Science.gov (United States)

    Turkcan, Ayten; Toscos, Tammy; Doebbeling, Brad N

    2014-01-01

    Enhanced access and continuity are key components of patient-centered care. Existing studies show that several interventions such as providing same day appointments, walk-in services, after-hours care, and group appointments, have been used to redesign the healthcare systems for improved access to primary care. However, an intervention focusing on a single component of care delivery (i.e. improving access to acute care) might have a negative impact other components of the system (i.e. reduced continuity of care for chronic patients). Therefore, primary care clinics should consider implementing multiple interventions tailored for their patient population needs. We collected rapid ethnography and observations to better understand clinic workflow and key constraints. We then developed an agent-based simulation model that includes all access modalities (appointments, walk-ins, and after-hours access), incorporate resources and key constraints and determine the best appointment scheduling method that improves access and continuity of care. This paper demonstrates the value of simulation models to test a variety of alternative strategies to improve access to care through scheduling. PMID:25954423

  4. E-laboratories : agent-based modeling of electricity markets

    International Nuclear Information System (INIS)

    Electricity markets are complex adaptive systems that operate under a wide range of rules that span a variety of time scales. These rules are imposed both from above by society and below by physics. Many electricity markets are undergoing or are about to undergo a transition from centrally regulated systems to decentralized markets. Furthermore, several electricity markets have recently undergone this transition with extremely unsatisfactory results, most notably in California. These high stakes transitions require the introduction of largely untested regulatory structures. Suitable laboratories that can be used to test regulatory structures before they are applied to real systems are needed. Agent-based models can provide such electronic laboratories or ''e-laboratories.'' To better understand the requirements of an electricity market e-laboratory, a live electricity market simulation was created. This experience helped to shape the development of the Electricity Market Complex Adaptive Systems (EMCAS) model. To explore EMCAS' potential as an e-laboratory, several variations of the live simulation were created. These variations probed the possible effects of changing power plant outages and price setting rules on electricity market prices

  5. Agents Based e-Commerce and Securing Exchanged Information

    Science.gov (United States)

    Al-Jaljouli, Raja; Abawajy, Jemal

    Mobile agents have been implemented in e-Commerce to search and filter information of interest from electronic markets. When the information is very sensitive and critical, it is important to develop a novel security protocol that can efficiently protect the information from malicious tampering as well as unauthorized disclosure or at least detect any malicious act of intruders. In this chapter, we describe robust security techniques that ensure a sound security of information gathered throughout agent’s itinerary against various security attacks, as well as truncation attacks. A sound security protocol is described, which implements the various security techniques that would jointly prevent or at least detect any malicious act of intruders. We reason about the soundness of the protocol usingSymbolic Trace Analyzer (STA), a formal verification tool that is based on symbolic techniques. We analyze the protocol in key configurations and show that it is free of flaws. We also show that the protocol fulfils the various security requirements of exchanged information in MAS, including data-integrity, data-confidentiality, data-authenticity, origin confidentiality and data non-repudiability.

  6. Agent-based modeling to simulate the dengue spread

    Science.gov (United States)

    Deng, Chengbin; Tao, Haiyan; Ye, Zhiwei

    2008-10-01

    In this paper, we introduce a novel method ABM in simulating the unique process for the dengue spread. Dengue is an acute infectious disease with a long history of over 200 years. Unlike the diseases that can be transmitted directly from person to person, dengue spreads through a must vector of mosquitoes. There is still no any special effective medicine and vaccine for dengue up till now. The best way to prevent dengue spread is to take precautions beforehand. Thus, it is crucial to detect and study the dynamic process of dengue spread that closely relates to human-environment interactions where Agent-Based Modeling (ABM) effectively works. The model attempts to simulate the dengue spread in a more realistic way in the bottom-up way, and to overcome the limitation of ABM, namely overlooking the influence of geographic and environmental factors. Considering the influence of environment, Aedes aegypti ecology and other epidemiological characteristics of dengue spread, ABM can be regarded as a useful way to simulate the whole process so as to disclose the essence of the evolution of dengue spread.

  7. Agent-based simulation of alternative classroom evacuation scenarios

    Directory of Open Access Journals (Sweden)

    Runjiao Liu

    2016-03-01

    Full Text Available Due to the growing number of emergency accidents occurring around students, evacuation issues have become significantly important for both school officials and architects. Simply following construction codes cannot ensure that a building׳s layout is suitable for evacuation behaviors; therefore, to discover the suitable planning schemes, we have introduced an agent-based simulation model via Netlogo to investigate the interrelationships between evacuation efficiency and classroom layouts. Before conducting modeling experiments, both the simulation structure and the sensitivity to its parameter settings are examined by validation research and sensitivity analysis. Furthermore, to demonstrate the importance of conducting fire drills with students, two different types of behavior rules are designed to reflect the distinctive characteristics of students evacuating without instructions and students evacuating in good order. The general comparison results show us that the classroom layout with two exits shortens students׳ evacuation time, and the premeditated behavior rules, meaning that students who follow preset instructions to arrange their activities, not only escape faster but also have some advantages in ensuring their safety during the evacuation process. Moreover, at the end of this paper, several methods of improving this simulation model are proposed for more complex research in the future.

  8. An Agent-Based Model of Institutional Life-Cycles

    Directory of Open Access Journals (Sweden)

    Manuel Wäckerle

    2014-08-01

    Full Text Available We use an agent-based model to investigate the interdependent dynamics between individual agency and emergent socioeconomic structure, leading to institutional change in a generic way. Our model simulates the emergence and exit of institutional units, understood as generic governed social structures. We show how endogenized trust and exogenously given leader authority influences institutional change, i.e., diversity in institutional life-cycles. It turns out that these governed institutions (destructure in cyclical patterns dependent on the overall evolution of trust in the artificial society, while at the same time, influencing this evolution by supporting social learning. Simulation results indicate three scenarios of institutional life-cycles. Institutions may, (1 build up very fast and freeze the artificial society in a stable but fearful pattern (ordered system; (2 exist only for a short time, leading to a very trusty society (highly fluctuating system; and (3 structure in cyclical patterns over time and support social learning due to cumulative causation of societal trust (complex system.

  9. Improving Multi agent Systems Based on Reinforcement Learning and Case Base Reasoning

    OpenAIRE

    Sara Esfandiari; Behrooz Masoumi; Mohammadreza Meybodi; Abdolkarim Niazi

    2012-01-01

    In this paper, a new algorithm based on case base reasoning and reinforcement learning is proposed to increase the rate convergence of the Selfish Q-Learning algorithms in multi-agent systems. In the propose method, we investigate how making improved action selection in reinforcement learning (RL) algorithm. In the proposed method, the new combined model using case base reasoning systems and a new optimized function has been proposed to select the action, which has led to an increase in algor...

  10. AGENT-BASED CROWD SIMULATION CONSIDERING EMOTION CONTAGION FOR EMERGENCY EVACUATION PROBLEM

    Directory of Open Access Journals (Sweden)

    H. Faroqi

    2015-12-01

    Full Text Available During emergencies, emotions greatly affect human behaviour. For more realistic multi-agent systems in simulations of emergency evacuations, it is important to incorporate emotions and their effects on the agents. In few words, emotional contagion is a process in which a person or group influences the emotions or behavior of another person or group through the conscious or unconscious induction of emotion states and behavioral attitudes. In this study, we simulate an emergency situation in an open square area with three exits considering Adults and Children agents with different behavior. Also, Security agents are considered in order to guide Adults and Children for finding the exits and be calm. Six levels of emotion levels are considered for each agent in different scenarios and situations. The agent-based simulated model initialize with the random scattering of agent populations and then when an alarm occurs, each agent react to the situation based on its and neighbors current circumstances. The main goal of each agent is firstly to find the exit, and then help other agents to find their ways. Numbers of exited agents along with their emotion levels and damaged agents are compared in different scenarios with different initialization in order to evaluate the achieved results of the simulated model. NetLogo 5.2 is used as the multi-agent simulation framework with R language as the developing language.

  11. Agent-Based Crowd Simulation Considering Emotion Contagion for Emergency Evacuation Problem

    Science.gov (United States)

    Faroqi, H.; Mesgari, M.-S.

    2015-12-01

    During emergencies, emotions greatly affect human behaviour. For more realistic multi-agent systems in simulations of emergency evacuations, it is important to incorporate emotions and their effects on the agents. In few words, emotional contagion is a process in which a person or group influences the emotions or behavior of another person or group through the conscious or unconscious induction of emotion states and behavioral attitudes. In this study, we simulate an emergency situation in an open square area with three exits considering Adults and Children agents with different behavior. Also, Security agents are considered in order to guide Adults and Children for finding the exits and be calm. Six levels of emotion levels are considered for each agent in different scenarios and situations. The agent-based simulated model initialize with the random scattering of agent populations and then when an alarm occurs, each agent react to the situation based on its and neighbors current circumstances. The main goal of each agent is firstly to find the exit, and then help other agents to find their ways. Numbers of exited agents along with their emotion levels and damaged agents are compared in different scenarios with different initialization in order to evaluate the achieved results of the simulated model. NetLogo 5.2 is used as the multi-agent simulation framework with R language as the developing language.

  12. Agent-based simulation of building evacuation using a grid graph-based model

    International Nuclear Information System (INIS)

    Shifting from macroscope models to microscope models, the agent-based approach has been widely used to model crowd evacuation as more attentions are paid on individualized behaviour. Since indoor evacuation behaviour is closely related to spatial features of the building, effective representation of indoor space is essential for the simulation of building evacuation. The traditional cell-based representation has limitations in reflecting spatial structure and is not suitable for topology analysis. Aiming at incorporating powerful topology analysis functions of GIS to facilitate agent-based simulation of building evacuation, we used a grid graph-based model in this study to represent the indoor space. Such model allows us to establish an evacuation network at a micro level. Potential escape routes from each node thus could be analysed through GIS functions of network analysis considering both the spatial structure and route capacity. This would better support agent-based modelling of evacuees' behaviour including route choice and local movements. As a case study, we conducted a simulation of emergency evacuation from the second floor of an official building using Agent Analyst as the simulation platform. The results demonstrate the feasibility of the proposed method, as well as the potential of GIS in visualizing and analysing simulation results

  13. Web Crawler Based on Mobile Agent and Java Aglets

    OpenAIRE

    Md. Abu Kausar; V. S. Dhaka; Sanjeev Kumar Singh

    2013-01-01

    With the huge growth of the Internet, many web pages are available online. Search engines use web crawlers to collect these web pages from World Wide Web for the purpose of storage and indexing. Basically Web Crawler is a program, which finds information from the World Wide Web in a systematic and automated manner. This network load farther will be reduced by using mobile agents.The proposed approach uses mobile agents to crawl the pages. A mobile agent is not bound to the system in which it ...

  14. Improved tumor-targeting MRI contrast agents: Gd(DOTA) conjugates of a cycloalkane-based RGD peptide

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ji-Ae, E-mail: jpark@kirams.re.kr [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Yong Jin; Ko, In Ok [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Tae-Jeong; Chang, Yongmin [Institute of Biomedical Engineering, Kyungpook National University, Daegu (Korea, Republic of); Lim, Sang Moo [Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Kyeong Min [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Jung Young, E-mail: jykim@kirams.re.kr [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2014-12-12

    Highlights: • Development of improved tumor-targeting MRI contrast agents. • To increase the targeting ability of RGD, we developed cycloalkane-based RGD peptides. • Gd(DOTA) conjugates of cycloalkane-based RGD peptide show improved tumor signal enhancement in vivo MR images. - Abstract: Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA (gadolinium-tetraazacyclo dodecanetetraacetic acid) and cyclic RGDK peptides, were synthesized and evaluated for tumor-targeting ability in vitro and in vivo. Binding affinity studies showed that both 1 and 2 exhibited higher affinity for integrin receptors than cyclic RGDyK peptides, which were used as a reference. These complexes showed high relaxivity and good stability in human serum and have the potential to improve target-specific signal enhancement in vivo MR images.

  15. Improved tumor-targeting MRI contrast agents: Gd(DOTA) conjugates of a cycloalkane-based RGD peptide

    International Nuclear Information System (INIS)

    Highlights: • Development of improved tumor-targeting MRI contrast agents. • To increase the targeting ability of RGD, we developed cycloalkane-based RGD peptides. • Gd(DOTA) conjugates of cycloalkane-based RGD peptide show improved tumor signal enhancement in vivo MR images. - Abstract: Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA (gadolinium-tetraazacyclo dodecanetetraacetic acid) and cyclic RGDK peptides, were synthesized and evaluated for tumor-targeting ability in vitro and in vivo. Binding affinity studies showed that both 1 and 2 exhibited higher affinity for integrin receptors than cyclic RGDyK peptides, which were used as a reference. These complexes showed high relaxivity and good stability in human serum and have the potential to improve target-specific signal enhancement in vivo MR images

  16. Mercury Control with Calcium-Based Sorbents and Oxidizing Agents

    Energy Technology Data Exchange (ETDEWEB)

    Thomas K. Gale

    2005-07-01

    This Final Report contains the test descriptions, results, analysis, correlations, theoretical descriptions, and model derivations produced from many different investigations performed on a project funded by the U.S. Department of Energy, to investigate calcium-based sorbents and injection of oxidizing agents for the removal of mercury. Among the technologies were (a) calcium-based sorbents in general, (b) oxidant-additive sorbents developed originally at the EPA, and (c) optimized calcium/carbon synergism for mercury-removal enhancement. In addition, (d) sodium-tetrasulfide injection was found to effectively capture both forms of mercury across baghouses and ESPs, and has since been demonstrated at a slipstream treating PRB coal. It has been shown that sodium-tetrasulfide had little impact on the foam index of PRB flyash, which may indicate that sodium-tetrasulfide injection could be used at power plants without affecting flyash sales. Another technology, (e) coal blending, was shown to be an effective means of increasing mercury removal, by optimizing the concentration of calcium and carbon in the flyash. In addition to the investigation and validation of multiple mercury-control technologies (a through e above), important fundamental mechanism governing mercury kinetics in flue gas were elucidated. For example, it was shown, for the range of chlorine and unburned-carbon (UBC) concentrations in coal-fired utilities, that chlorine has much less effect on mercury oxidation and removal than UBC in the flyash. Unburned carbon enhances mercury oxidation in the flue gas by reacting with HCl to form chlorinated-carbon sites, which then react with elemental mercury to form mercuric chloride, which subsequently desorbs back into the flue gas. Calcium was found to enhance mercury removal by stabilizing the oxidized mercury formed on carbon surfaces. Finally, a model was developed to describe these mercury adsorption, desorption, oxidation, and removal mechanisms, including

  17. Improving Multi agent Systems Based on Reinforcement Learning and Case Base Reasoning

    Directory of Open Access Journals (Sweden)

    Sara Esfandiari

    2012-01-01

    Full Text Available In this paper, a new algorithm based on case base reasoning and reinforcement learning is proposed to increase the rate convergence of the Selfish Q-Learning algorithms in multi-agent systems. In the propose method, we investigate how making improved action selection in reinforcement learning (RL algorithm. In the proposed method, the new combined model using case base reasoning systems and a new optimized function has been proposed to select the action, which has led to an increase in algorithms based on Selfish Q-learning. The algorithm mentioned has been used for solving the problem of cooperative Markovs games as one of the models of Markov based multi-agent systems. The results of experiments on two ground have shown that the proposed algorithm perform better than the existing algorithms in terms of speed and accuracy of reaching the optimal policy.

  18. Modeling of Agile Manufacturing Execution Systems with an Agent-based Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Agile manufacturing execution systems (AMES) are used to help manufacturers optimize shop floor production in an agile way. And the modeling of AMES is the key issue of realizing AMES. This paper presents an agent-based approach to AMES modeling. Firstly, the characteristics of AMES and its requirements on modeling are discussed. Secondly, a comparative analysis of modeling methods is carried out, and AMES modeling using an agent-based approach is put forward. Agent-based modeling method not only inherit ...

  19. Integrating Activity-Based Costing with Target Costing and Principal-Agent Incentives

    OpenAIRE

    Xiaoyuan Huang; Lijun Li; Liping Yu

    2009-01-01

    The current studies of cost management mainly focus on the cost control of transactions and activities, which is a basic function of cost management. This paper analyzes activity-based costing (ABC) and principal-agent incentives, and target costing (TC) and principal-agent incentives with regard to both functional and institutional aspects of cost management in agent theory framework, and reaches the point that a integration of activity-based costing and target costing based on principal-age...

  20. An Introduction to Agent Based Modelling and Simulation of Social Processes

    OpenAIRE

    Ognjen Skunca; Armano Srbljinovic

    2003-01-01

    The paper provides an introduction to agent-based modelling and simulation of social processes. Reader is introduced to the worldview underlying agent-based models, some basic terminology, basic properties of agent-based models, as well as to what one can and what cannot expect from such models, particularly when they are applied to social-scientific investigation. Special attention is given to the issues of validation.

  1. Agent-Based Modelling: Tools for Linking NetLogo and r

    OpenAIRE

    Jan C Thiele; Winfried Kurth; Volker Grimm

    2012-01-01

    A seamless integration of software platforms for implementing agent-based models and for analysing their output would facilitate comprehensive model analyses and thereby make agent-based modelling more useful. Here we report on recently developed tools for linking two widely used software platforms: NetLogo for implementing agent-based models, and R for the statistical analysis and design of experiments. Embedding R into NetLogo allows the use of advanced statistical analyses, specific statis...

  2. Using FLAME Toolkit for Agent-Based Simulation: Case Study Sugarscape Model

    OpenAIRE

    Kiran, Mariam

    2014-01-01

    Social scientists have used agent-based models to understand how individuals interact and behave in various political, ecological and economic scenarios. Agent-based models are ideal for understanding such models involving interacting individuals producing emergent phenomenon. Sugarscape is one of the most famous examples of a social agent-based model which has been used to show how societies grow in the real world. This paper builds on the Sugarscape model, using the Flexible Large scale Age...

  3. Intermittent observer-based consensus control for multi-agent systems with switching topologies

    Science.gov (United States)

    Xu, Xiaole; Gao, Lixin

    2016-06-01

    In this paper, we focus on the consensus problem for leaderless and leader-followers multi-agent systems with periodically intermittent control. The dynamics of each agent in the system is a linear system, and the interconnection topology among the agents is assumed to be switching. We assume that each agent can only share the outputs with its neighbours. Therefore, a class of distributed intermittent observer-based consensus protocols are proposed for each agent. First, in order to solve this problem, a parameter-dependent common Lyapunov function is constructed. Using this function, we prove that all agents can access a prescribed value, under the designed intermittent controller and observer, if there are suitable conditions on communication. Second, based on the investigation of the leader-following consensus problem, we design a new distributed intermittent observer-based protocol for each following agent. Finally, we provide an illustrative example to verify the effectiveness of the proposed approach.

  4. Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents

    Directory of Open Access Journals (Sweden)

    Dianjun Liu

    2013-05-01

    Full Text Available Because magnetic resonance imaging (MRI contrast agents play a vital role in diagnosing diseases, demand for new MRI contrast agents, with an enhanced sensitivity and advanced functionalities, is very high. During the past decade, various inorganic nanoparticles have been used as MRI contrast agents due to their unique properties, such as large surface area, easy surface functionalization, excellent contrasting effect, and other size-dependent properties. This review provides an overview of recent progress in the development of nanoparticle-based T1-weighted MRI contrast agents. The chemical synthesis of the nanoparticle-based contrast agents and their potential applications were discussed and summarized. In addition, the recent development in nanoparticle-based multimodal contrast agents including T1-weighted MRI/computed X-ray tomography (CT and T1-weighted MRI/optical were also described, since nanoparticles may curtail the shortcomings of single mode contrast agents in diagnostic and clinical settings by synergistically incorporating functionality.

  5. Demeter, persephone, and the search for emergence in agent-based models.

    Energy Technology Data Exchange (ETDEWEB)

    North, M. J.; Howe, T. R.; Collier, N. T.; Vos, J. R.; Decision and Information Sciences; Univ. of Chicago; PantaRei Corp.; Univ. of Illinois

    2006-01-01

    In Greek mythology, the earth goddess Demeter was unable to find her daughter Persephone after Persephone was abducted by Hades, the god of the underworld. Demeter is said to have embarked on a long and frustrating, but ultimately successful, search to find her daughter. Unfortunately, long and frustrating searches are not confined to Greek mythology. In modern times, agent-based modelers often face similar troubles when searching for agents that are to be to be connected to one another and when seeking appropriate target agents while defining agent behaviors. The result is a 'search for emergence' in that many emergent or potentially emergent behaviors in agent-based models of complex adaptive systems either implicitly or explicitly require search functions. This paper considers a new nested querying approach to simplifying such agent-based modeling and multi-agent simulation search problems.

  6. ENACTED SOFTWARE DEVELOPMENT PROCESS BASED ON AGILE AND AGENT METHODOLOGIES

    Directory of Open Access Journals (Sweden)

    DR. NACHAMAI. M

    2011-11-01

    Full Text Available Software Engineering gives the procedures and practices to be followed in the software development and acts as a backbone for computer science engineering techniques. This paper deals with current trends in software engineering methodologies, Agile and Agent Oriented software development process. Agile Methodology is to meet the needs of dynamic changing requirements of the customers. This model is iterative and incremental and accepts the changes in requirements at any stage of development. Agent oriented software’s is a rapidly developing area of research , Software agents are an innovative technology designed to support the development of complex, distributed, and heterogeneous information systems. The work of paper weight against factors of agile and agent oriented software development process on the basis of Architectural Design ,Applicability,Project Duration, Customer Interaction Level, Team collaboration, Documentation, Software Models.

  7. An Agent Based Software Approach towards Building Complex Systems

    Directory of Open Access Journals (Sweden)

    Latika Kharb

    2015-08-01

    Full Text Available Agent-oriented techniques represent an exciting new means of analyzing, designing and building complex software systems. They have the potential to significantly improve current practice in software engineering and to extend the range of applications that can feasibly be tackled. Yet, to date, there have been few serious attempts to cast agent systems as a software engineering paradigm. This paper seeks to rectify this omission. Specifically, points to be argued include:firstly, the conceptual apparatus of agent-oriented systems is well-suited to building software solutions for complex systems and secondly, agent-oriented approaches represent a genuine advance over the current state of the art for engineering complex systems. Following on from this view, the major issues raised by adopting an agentoriented approach to software engineering are highlighted and discussed in this paper.

  8. Designing Electronic Markets for Defeasible-based Contractual Agents

    OpenAIRE

    Groza, Adrian

    2013-01-01

    The design of punishment policies applied to specific domains linking agents actions to material penalties is an open research issue. The proposed framework applies principles of contract law to set penalties: expectation damages, opportunity cost, reliance damages, and party design remedies. In order to decide which remedy provides maximum welfare within an electronic market, a simulation environment called DEMCA (Designing Electronic Markets for Contractual Agents) was developed. Knowledge ...

  9. Agent Based Sensor and Data Fusion in Forest Fire Observer

    OpenAIRE

    &#;erić, Ljiljana; Stipani&#;ev, Darko; &#;tula, Maja

    2009-01-01

    Inspirited by the formal theory of perception and technology of sensor network we have introduced the idea of observer network as a reliable framework for data and information fusion. Our ideas have been successfully tested in the case of forest fire observer network. Observer network was implemented using multi-agent technology. A special multi agent shell was designed for this purpose having software system desirable features like modularity and flexibility. The system was implemented in nu...

  10. Using the Agent-Based Modeling in Economic Field

    Directory of Open Access Journals (Sweden)

    Nora Mihail

    2006-10-01

    For ABM, a complex system is a system of individual agents who have the freedom to act in ways that are not always totally predictable, and whose actions are interconnected such that one agent’s actions changes the context (environment for other agents. These are many examples of such complex systems: the stock market, the human body immune system, a business organization, an institution, a work-team, a family etc.

  11. A practical situation based agent architecture for social simulations

    OpenAIRE

    Alt, Jonathan K.; Baez, Francisco; Darken, Christian J.

    2011-01-01

    The concept of situation is central to the decision making processes of both human and software agents. The recognition of situation facilitates decision processes that ultimately result in action selection. Cognitive agent architectures that incorporate the concept of situation provide the opportunity for more sophisticated representation of human behavior and for more sophisticated decision support applications. This paper provides an overview of a general cognitive architecture for use ...

  12. AGENT-BASED DESIGN OF BUSINESS INTELLIGENCE SYSTEM ARCHITECTURE

    OpenAIRE

    Roman Å PERKA

    2012-01-01

    Business intelligence is a business management term used to describe applications and technologies which are used to gather, provide access to, and analyse data and information about the organization, to help make better business decisions. The multi-agent approach provides a feasible solution for construction of the business intelligence system. This paper firstly briefly introduces the traditional business intelligence architecting principles and multi-agent approach. Secondly, a design of ...

  13. Performance Analysis of Agent based IPSM for Windows based Operating Systems

    Directory of Open Access Journals (Sweden)

    Deepshikha Bhargava

    2013-07-01

    Full Text Available All processes prevent casual exchange of data.However, occasionally two processes might need to communicatewith each other. One method that enables processes tocommunicate is called Inter Process Synchronization (IPS. In anOperating System on which several threads run concurrently, it isimportant to be able to synchronize the activities of variousthreads. Windows provides several synchronization objects thatenable to synchronize a thread's actions with those of anotherthread. These objects include critical sections, mutexes, events,and semaphores. The different solutions for Inter ProcessSynchronization problem are suggested [1] where some of thesesolutions have their own limitations or performance related issues.The agent based approach used in this paper has suggested a newalgorithm for agent IPSM which is an attempt to propose anoptimal solution to the problem. IPSM stands for Inter ProcessSynchronization Manager which is an agent used for solving theproblem of inter process synchronization. In the present paperagent based Inter Process Synchronization Manager (IPSM isdescribed and its performance is compared with agent based IPSMon different Windows based operating systems.

  14. Agent based Particle Swarm Optimization for Load Frequency Control of Distribution Grid

    DEFF Research Database (Denmark)

    Cha, Seung-Tae; Saleem, Arshad; Wu, Qiuwei;

    2012-01-01

    This paper presents a Particle Swarm Optimization (PSO) based on multi-agent controller. Real-time digital simulator (RTDS) is used for modelling the power system, while a PSO based multi-agent LFC algorithm is developed in JAVA for communicating with resource agents and determines the scenario...... to stabilize the frequency and voltage after the system enters into the islanding operation mode. The proposed algorithm is based on the formulation of an optimization problem using agent based PSO. The modified IEEE 9-bus system is employed to illustrate the performance of the proposed controller via RTDS...

  15. Multi-level agent-based modeling with the Influence Reaction principle

    OpenAIRE

    Morvan, Gildas; Jolly, Daniel

    2012-01-01

    This paper deals with the specification and the implementation of multi-level agent-based models, using a formal model, IRM4MLS (an Influence Reaction Model for Multi-Level Simulation), based on the Influence Reaction principle. Proposed examples illustrate forms of top-down control in (multi-level) multi-agent based-simulations.

  16. Multi-agent System for Process Planning in Step-nc Based Manufacturing

    Directory of Open Access Journals (Sweden)

    Juan Du

    2012-09-01

    Full Text Available In order to realize STEP-NC-oriented computer numerical control machining and achieve optimal performance in manufacturing, a multi-agent system for process planning in STEP-NC based manufacturing was designed. By analyzing the characteristic of STEP-NC data model, a manufacturing feature-oriented process planning method was proposed in this study and the distributed artificial intelligence methods, namely collaborative multi-agent was employed to accomplish process planning of part. The proposed multi-agent system consists of three types of autonomous agents, which are global manager agents, planning agents and manufacturing resource agents, respectively. Process planning can be automatically completed by multiple agents’ cooperation. Each agent is capable of communicating to each other through improved Knowledge Query and Manipulation Language (KQML. At last, one test part was designed and simulated to demonstrate the capabilities of this research in the study.

  17. Multi Agent System-Based on Case Based Reasoning for Cloud Computing System

    OpenAIRE

    Talib, Amir Mohamed; Elshaiekh, Nour Eldin Mohamed

    2014-01-01

    Cloud Computing is a new technology which use the Internet and central remote servers in order to maintain data and applications. The aim of this paper is to describe about Case Based Reasoning (CBR) which is based on Multi Agent System (MAS) and the implementation in Cloud Computing Environment to assist the Cloud Service Provider (CSP) to deliver a number of services to the cloud users according to their needs. The Introduction Section gives an introduction about Cloud Computing, MAS and CB...

  18. An Agent-Based Model of Collective Emotions in Online Communities

    CERN Document Server

    Schweitzer, Frank

    2010-01-01

    We develop a agent-based framework to model the emergence of collective emotions, which is applied to online communities. Agents individual emotions are described by their valence and arousal. Using the concept of Brownian agents, these variables change according to a stochastic dynamics, which also considers the feedback from online communication. Agents generate emotional information, which is stored and distributed in a field modeling the online medium. This field affects the emotional states of agents in a non-linear manner. We derive conditions for the emergence of collective emotions, observable in a bimodal valence distribution. Dependent on a saturated or a superlinear feedback between the information field and the agent's arousal, we further identify scenarios where collective emotions only appear once or in a repeated manner. The analytical results are illustrated by agent-based computer simulations. Our framework provides testable hypotheses about the emergence of collective emotions, which can be ...

  19. Multi-agent reinforcement learning based on policies of global objective

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In general-sum games, taking all agent's collective rationality into account, we define agents' global objective,and propose a novel multi-agent reinforcement learning(RL) algorithm based on global policy. In each learning step, all agents commit to select the global policy to achieve the global goal. We prove this learning algorithm converges given certain restrictions on stage games of learned Q values, and show that it has quite lower computation time complexity than already developed multi-agent learning algorithms for general-sum games. An example is analyzed to show the algorithm' s merits.

  20. A Distributed Data Mining System Based on Multi-agent Technology

    Institute of Scientific and Technical Information of China (English)

    GUO Li-ming; ZHANG Yan-zhen

    2006-01-01

    Distributed Data Mining is expected to discover preciously unknown, implicit and valuable information from massive data set inherently distributed over a network. In recent years several approaches to distributed data mining have been developed, but only a few of them make use of intelligent agents. This paper provides the reason for applying Multi-Agent Technology in Distributed Data Mining and presents a Distributed Data Mining System based on Multi-Agent Technology that deals with heterogeneity in such environment. Based on the advantages of both the CS model and agent-based model, the system is being able to address the specific concern of increasing scalability and enhancing performance.

  1. New Trends in Agent-Based Complex Automated Negotiations

    CERN Document Server

    Zhang, Minjie; Robu, Valentin; Fatima, Shaheen; Matsuo, Tokuro

    2012-01-01

    Complex Automated Negotiations represent an important, emerging area in the field of Autonomous Agents and Multi-Agent Systems. Automated negotiations can be complex, since there are a lot of factors that characterize such negotiations. These factors include the number of issues, dependencies between these issues,  representation of utilities, the negotiation protocol, the number of parties in the negotiation (bilateral or multi-party), time constraints, etc. Software agents can support automation or simulation of such complex negotiations on the behalf of their owners, and can provide them with efficient bargaining strategies. To realize such a complex automated negotiation, we have to incorporate advanced Artificial Intelligence technologies includes search, CSP, graphical utility models, Bayes nets, auctions, utility graphs, predicting and learning methods. Applications could include e-commerce tools, decision-making support tools, negotiation support tools, collaboration tools, etc. This book aims to pro...

  2. E-learning paradigms and applications agent-based approach

    CERN Document Server

    Jain, Lakhmi

    2014-01-01

    Teaching and learning paradigms have attracted increased attention especially in the last decade. Immense developments of different ICT technologies and services have paved the way for alternative but effective approaches in educational processes. Many concepts of the agent technology, such as intelligence, autonomy, and cooperation, have had a direct positive impact on many of the requests imposed on modern e-learning systems and educational processes. This book presents the state-of-the-art of e-learning and tutoring systems, and discusses their capabilities and benefits that stem from integrating software agents. We hope that the presented work will be of a great use to our colleagues and researchers interested in the e-learning and agent technology.    

  3. A generic agent-based framework for cooperative search using pattern matching and reinforcement learning

    OpenAIRE

    Martin, Simon; Ouelhadj, Djamila; Beullens, P.; Ozcan, E.

    2011-01-01

    Cooperative search provides a class of strategies to design more effective search methodologies through combining (meta-) heuristics for solving combinatorial optimisation problems. This area has been little explored in operational research. In this study, we propose a general agent-based distributed framework where each agent implements a (meta-) heuristic. An agent continuously adapts itself during the search process using a cooperation protocol based on reinforcement learning and pattern m...

  4. Supply Chain Management System Model of Virtual Enterprises Based on Multi-Agent

    Institute of Scientific and Technical Information of China (English)

    LI Zhen; ZHANG Pei-pei

    2008-01-01

    Based on the analysis of a virtual enterprise and the development of supply chain management, their integration is proposed. Then, the difference between multi-agent system modeling method and the traditional modeling method is analyzed, and a method based on Java agent framework for multi-agent systems(JAFMAS) is proposed. By using this method the virtual enterprise's supply chain management system model is established.

  5. Multi-level and Secured Agent-based Intrusion Detection System

    OpenAIRE

    Sodiya, Adesina Simon

    2006-01-01

    Since Intrusion Detection System (IDS) has become necessary security tool for detecting attacks on computer network and resources, it is therefore essential to improve on previous designs. In past, many mobile agent-based IDSs have been designed, but there still exists some drawbacks. Some of these drawbacks are low detection efficiency, high false alarm rate and agent security. A multi-level and secured IDS architecture that is based on mobile agent is presented on this work to correct these...

  6. Pattern-Oriented Modeling of Agent-Based Complex Systems: Lessons from Ecology

    OpenAIRE

    Grimm, Volker; Revilla, Eloy; Berger, Uta; Jeltsch, Florian; Mooij, Wolf M.; Railsback, Steven F.; Thulke, Hans-Hermann; Weiner, Jacob; Wiegand, Thorsten; Donald L DeAngelis

    2005-01-01

    Agent-based complex systems are dynamic networks of many interacting agents; examples include ecosystems, financial markets, and cities. The search for general principles underlying the internal organization of such systems often uses bottom-up simulation models such as cellular automata and agent-based models. No general framework for designing, testing, and analyzing bottom-up models has yet been established, but recent advances in ecological modeling have come together in a genera...

  7. Agent-Based Modeling and Genetic Algorithm Simulation for the Climate Game Problem

    OpenAIRE

    Zheng Wang; Jingling Zhang

    2012-01-01

    The cooperative game of global temperature lacks automaticity and emotional jamming. To solve this issue, an agent-based modelling method is developed based on Milinski’s noncooperative game experiments. In addition, genetic algorithm is used to improve the investment strategy of each agent. Simulations are carried out by designing different coding schemes, mutation schemes, and fitness functions. It is demonstrated that the method can achieve maximum benefits under the premise of the agent n...

  8. A multi-agent system to support location based group decision making in mobile teams

    OpenAIRE

    Lee, H; Buckland, MA; Shepherdson, JW

    2003-01-01

    This paper describes an agent-based approach for developing a location-based asynchronous group decision-support system for mobile teams. The approach maximises the use of reusable service components (GSCmas — generic service component for multi-agent systems) as the main interaction mechanism between agents to allow flexible support of a new group-decision process. The paper describes the architecture of a GSCmas and provides details of how the GSCmas is integrated within a decision...

  9. An Agent-Based Approach to Care in Independent Living

    Science.gov (United States)

    Kaluža, Boštjan; Mirchevska, Violeta; Dovgan, Erik; Luštrek, Mitja; Gams, Matjaž

    This paper presents a multi-agent system for the care of elderly people living at home on their own, with the aim to prolong their independence. The system is composed of seven groups of agents providing a reliable, robust and flexible monitoring by sensing the user in the environment, reconstructing the position and posture to create the physical awareness of the user in the environment, reacting to critical situations, calling for help in the case of an emergency, and issuing warnings if unusual behavior is detected. The system has been tested during several on-line demonstrations.

  10. Improvising Linguistic Style Social and Affective Bases for Agent Personality

    CERN Document Server

    Walker, M A; Whittaker, S J; Walker, Marilyn A.; Cahn, Janet E.; Whittaker, Stephen J.

    1997-01-01

    This paper introduces Linguistic Style Improvisation, a theory and set of algorithms for improvisation of spoken utterances by artificial agents, with applications to interactive story and dialogue systems. We argue that linguistic style is a key aspect of character, and show how speech act representations common in AI can provide abstract representations from which computer characters can improvise. We show that the mechanisms proposed introduce the possibility of socially oriented agents, meet the requirements that lifelike characters be believable, and satisfy particular criteria for improvisation proposed by Hayes-Roth.

  11. A Q-based integrating interaction framework system for multi-agent coordination

    Institute of Scientific and Technical Information of China (English)

    WANG Zhen-jie; SHENG Huan-ye; XIAO Zheng-guang

    2005-01-01

    Interaction is one of the crucial features of multi-agent systems, in which there are two kinds of interaction: agent-to-agent and human-to-agent. In order to unify the two kinds of interaction while designing multiagent systems, this paper introduces Q language-a scenario description language for designing interaction among agents and humans. Based on Q, we propose an integrating interaction framework system for multi-agent coordination, in which Q scenarios are used to uniformly describe both kinds of interactions. Being in accordance to the characteristics of Q language, the Q-based framework makes the interaction process open and easily understood by the users. Additionally, it makes specific applications of multi-agent systems easy to be established by application designers. By applying agent negotiation in agent-mediated e-commerce and agent cooperation in interoperable information query on the Semantic Web, we illustrate how the presented framework for multi-agent coordination is implemented in concrete applications. At the same time, these two different applications also demonstrate usability of the presented framework and verify validity of Q language.

  12. Agent-based model of information spread in social networks

    CERN Document Server

    Lande, D V; Berezin, B O

    2016-01-01

    We propose evolution rules of the multiagent network and determine statistical patterns in life cycle of agents - information messages. The main discussed statistical pattern is connected with the number of likes and reposts for a message. This distribution corresponds to Weibull distribution according to modeling results. We examine proposed model using the data from Twitter, an online social networking service.

  13. Anticancer agent-based marine natural products and related compounds.

    Science.gov (United States)

    Chen, Jian-Wei; Wu, Qi-Hao; Rowley, David C; Al-Kareef, Ammar M Q; Wang, Hong

    2015-01-01

    Marine natural products constitute a huge reservoir of anticancer agents. Consequently during the past decades, several marine anticancer compounds have been isolated, identified, and approved for anticancer treatment or are under trials. In this article the sources, structure, bioactivities, mode of actions, and analogs of some promising marine and derived anticancer compounds have been discussed. PMID:25559315

  14. Signal amplification in an agent-based herding model

    CERN Document Server

    Carro, Adrián; Miguel, Maxi San

    2013-01-01

    A growing part of the behavioral finance literature has addressed some of the stylized facts of financial time series as macroscopic patterns emerging from herding interactions among groups of agents with heterogeneous trading strategies and a limited rationality. We extend a stochastic herding formalism introduced for the modeling of decision making among financial agents, in order to take also into account an external influence. In particular, we study the amplification of an external signal imposed upon the agents by a mechanism of resonance. This signal can be interpreted as an advertising or a public perception in favor or against one of the two possible trading behaviors, thus periodically breaking the symmetry of the system and acting as a continuously varying exogenous shock. The conditions for the ensemble of agents to more accurately follow the periodicity of the signal are studied, finding a maximum in the response of the system for a given range of values of both the noise and the frequency of the...

  15. An Agent Based Modelling Approach for Multi-Stakeholder Analysis of City Logistics Solutions

    NARCIS (Netherlands)

    Anand, N.

    2015-01-01

    This thesis presents a comprehensive framework for multi-stakeholder analysis of city logistics solutions using agent based modeling. The framework describes different stages for the systematic development of an agent based model for the city logistics domain. The framework includes a multi-perspect

  16. Macroeconomic Fluctuations and Propagation Mechanisms: An Agent-Based Simulation Model

    OpenAIRE

    Sella Lisa

    2009-01-01

    This paper proposes an agent-based simulation model exploring aggregate business fluctuations in an artificial market economy. It is inspired by the C++ agent-based simulation model in Howitt (2006), and proposes a modified NetLogo model, which provides new procedures and parameters aiming at analyzing the endogenous dynamics of market adjustment processes

  17. Inhibition of [3H]-dihydroalprenolol binding to rat cardiac membranes by various β-blocking agents

    International Nuclear Information System (INIS)

    Binding of [3H]-dihydroalprenolol ([3H]-DHA) to rat cardiac membranes was rapid and reversible (k1 = 0.633 to 0.701 x 106 M-1s-1 and ksub(-1) = 0.0017 to 0.0043 s-1). [3H]-DHA bound to a single class of binding sites with an equilibrium dissociation constant (Ksub(d250C) of 5.7 +- 1.1 x 10-9M. This binding was specific and the order of potency of adrenoceptor agonists in competing for the binding sites was (-)-isoproterenol > (+-)-isoproterenol >(+)-isoproterenol > (-)-adrenaline > (-)-noradrenaline. This was in agreement with the β1 nature of the cardiac β-receptors. Cardioselective β-blockers (i.e. metoprolol, acebutolol and practolol) were shown to have lower binding site affinities, when compared to other blockers. This may be related to steric hindrance by the side-chain at the aromatic end of these molecules. (author)

  18. Can Human-Like Bots Control Collective Mood: Agent-Based Simulations of Online Chats

    CERN Document Server

    Tadic, Bosiljka

    2013-01-01

    Using agent-based modeling approach, in this paper, we study self-organized dynamics of interacting agents in the presence of chat Bots. Different Bots with tunable ``human-like'' attributes, which exchange emotional messages with agents, are considered, and collective emotional behavior of agents is quantitatively analysed. In particular, using detrended fractal analysis we determine persistent fluctuations and temporal correlations in time series of agent's activity and statistics of avalanches carrying emotional messages of agents when Bots favoring positive/negative affects are active. We determine the impact of Bots and identify parameters that can modulate it. Our analysis suggests that, by these measures, the emotional Bots induce collective emotion among interacting agents by suitably altering the fractal characteristics of the underlying stochastic process.Positive-emotion Bots are slightly more effective than the negative ones. Moreover, the Bots which are periodically alternating between positive a...

  19. Symbolic Verification of a Strength Based Multi-Agent Argumentation Scheme

    Directory of Open Access Journals (Sweden)

    Shravan Shetty

    2011-05-01

    Full Text Available Software systems have evolved to the age of Artificial Intelligence (AI, consist- ing of independentautonomous agents interacting with each other in dynamic and unpredictable environments. In this kindof environment it is often very difficult to predict all the interactions between the agents. Henceverification of an interaction between multiple agents has become a key research area in AI. In this paperwe model and verify an Automatic Meeting Scheduling (AMS problem having multiple agentcommunication.The AMS problem helps us to emulate a real life scenario where multiple agents can argue over thedefined constraints. A weighted strength based argu- mentation scheme is proposed, where eachargument is weighed against each other to determine the strongest evidence. The argumentation modeldescribed in the paper have six agents: Initiator, Scheduler and four Participant agents. We haveformalized the agent interactions using Computation Tree Logic (CTL and verified the scheme byproviding suitable specifications (SPEC in a symbolic model verifier tool called, NuSMV.

  20. Mapping Cyclists’ Experiences and Agent-Based Modelling of Their Wayfinding Behaviour

    DEFF Research Database (Denmark)

    Snizek, Bernhard

    with spatial agents and model calibration data creation This paper has two objectives, which are to develop and present a method for simulating single GPS-based trajectories by applying an agent-based model and to acquire parameter values for CopenhagenABM, an agent-based model of cyclists’ behaviour. The core......This dissertation is about modelling cycling transport behaviour. It is partly about urban experiences seen by the cyclist and about modelling, more specifically the agent-based modelling of cyclists' wayfinding behaviour. The dissertation consists of three papers. The first deals...... into consideration. The resulting routes' overlap with routes taken from the real world was calculated and used as a qualifier for the capacity of the model to explain the real world phenomenon. The analyses and the conclusions from these model results are discussed at the end of the paper. CopenhagenABM: An Agent-based...

  1. CYB5D2 requires heme-binding to regulate HeLa cell growth and confer survival from chemotherapeutic agents.

    Directory of Open Access Journals (Sweden)

    Anthony Bruce

    Full Text Available The cytochrome b5 domain containing 2 (CYB5D2; Neuferricin protein has been reported to bind heme, however, the critical residues responsible for heme-binding are undefined. Furthermore, the relationship between heme-binding and CYB5D2-mediated intracellular functions remains unknown. Previous studies examining heme-binding in two cytochrome b5 heme-binding domain-containing proteins, damage-associated protein 1 (Dap1; Saccharomyces cerevisiae and human progesterone receptor membrane component 1 (PGRMC1, have revealed that conserved tyrosine (Y 73, Y79, aspartic acid (D 86, and Y127 residues present in human CYB5D2 may be involved in heme-binding. CYB5D2 binds to type b heme, however, only the substitution of glycine (G at D86 (D86G within its cytochrome b5 heme-binding (cyt-b5 domain abolished its heme-binding ability. Both CYB5D2 and CYB5D2(D86G localize to the endoplasmic reticulum. Ectopic CYB5D2 expression inhibited cell proliferation and anchorage-independent colony growth of HeLa cells. Conversely, CYB5D2 knockdown and ectopic CYB5D2(D86G expression increased cell proliferation and colony growth. As PGRMC1 has been reported to regulate the expression and activities of cytochrome P450 proteins (CYPs, we examined the role of CYB5D2 in regulating the activities of CYPs involved in sterol synthesis (CYP51A1 and drug metabolism (CYP3A4. CYB5D2 co-localizes with cytochrome P450 reductase (CYPOR, while CYB5D2 knockdown reduced lanosterol demethylase (CYP51A1 levels and rendered HeLa cells sensitive to mevalonate. Additionally, knockdown of CYB5D2 reduced CYP3A4 activity. Lastly, CYB5D2 expression conferred HeLa cell survival from chemotherapeutic agents (paclitaxel, cisplatin and doxorubicin, with its ability to promote survival being dependent on its heme-binding ability. Taken together, this study provides evidence that heme-binding is critical for CYB5D2 in regulating HeLa cell growth and survival, with endogenous CYB5D2 being required to

  2. Implementation and design of a communication system of an agent-based automated substation

    Institute of Scientific and Technical Information of China (English)

    LIN Yong-jun; LIU Yu-tao; ZHANG Dan-hui

    2006-01-01

    A substation system requires that communication be transmitted reliably,accurately and in real-time.Aimed at solving problems,e.g.,flow confliction and sensitive data transmission,a model of the communication system of an agent-based automated substation is introduced.The running principle is discussed in detail and each type of agent is discussed further.At the end,the realization of the agent system applied to the substation is presented.The outcome shows that the communication system of an agent-based automated substation improves the accuracy and reliability of the data transfer and presents it in realtime.

  3. Self-Organization and Autonomy in Computational Networks: Agents-based Contractual Workflow Paradigm

    Directory of Open Access Journals (Sweden)

    E.V.Krishnamurthy

    2012-02-01

    Full Text Available We describe an agents-based contractual workflow paradigm for Self-organization and autonomy in computational networks. The agent-based paradigm can be interpreted as the outcome arising out of deterministic, nondeterministic or stochastic interaction among a set of agents that includes the environment. These interactions are like chemical reactions and result in self-organization. Since the reaction rules are inherently parallel, any number of actions can be performed cooperatively or competitively among the subsets of elements, so that the agents carry out the required actions. Also we describe the application of this paradigm in finding short duration paths, chemical- patent mining, and in cloud computing services.

  4. Design and Simulation of Material-Integrated Distributed Sensor Processing with a Code-Based Agent Platform and Mobile Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    Stefan Bosse

    2015-02-01

    Full Text Available Multi-agent systems (MAS can be used for decentralized and self-organizing data processing in a distributed system, like a resource-constrained sensor network, enabling distributed information extraction, for example, based on pattern recognition and self-organization, by decomposing complex tasks in simpler cooperative agents. Reliable MAS-based data processing approaches can aid the material-integration of structural-monitoring applications, with agent processing platforms scaled to the microchip level. The agent behavior, based on a dynamic activity-transition graph (ATG model, is implemented with program code storing the control and the data state of an agent, which is novel. The program code can be modified by the agent itself using code morphing techniques and is capable of migrating in the network between nodes. The program code is a self-contained unit (a container and embeds the agent data, the initialization instructions and the ATG behavior implementation. The microchip agent processing platform used for the execution of the agent code is a standalone multi-core stack machine with a zero-operand instruction format, leading to a small-sized agent program code, low system complexity and high system performance. The agent processing is token-queue-based, similar to Petri-nets. The agent platform can be implemented in software, too, offering compatibility at the operational and code level, supporting agent processing in strong heterogeneous networks. In this work, the agent platform embedded in a large-scale distributed sensor network is simulated at the architectural level by using agent-based simulation techniques.

  5. An artificial economy based on reinforcement learning and agent based modeling

    OpenAIRE

    Fernando Lozano; Jaime Lozano; Mario García

    2007-01-01

    In this paper we employ techniques from artificial intelligence such as reinforcement learning and agent based modeling as building blocks of a computational model for an economy based on convention. First we model the interaction among firms in the private sector. These firms behave in an information environment based on conventions meaning that a firm is likely to behave as it neighbors if it observes that their actions lead to a good pay-off. On the other hand, we propose the use of reinfo...

  6. Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.

    Science.gov (United States)

    Kosmopoulou, Magda N; Leonidas, Demetres D; Chrysina, Evangelia D; Bischler, Nicolas; Eisenbrand, Gerhard; Sakarellos, Constantinos E; Pauptit, Richard; Oikonomakos, Nikos G

    2004-06-01

    The binding of indirubin-5-sulphonate (E226), a potential anti-tumour agent and a potent inhibitor (IC(50) = 35 nm) of cyclin-dependent kinase 2 (CDK2) and glycogen phosphorylase (GP) has been studied by kinetic and crystallographic methods. Kinetic analysis revealed that E226 is a moderate inhibitor of GPb (K(i) = 13.8 +/- 0.2 micro m) and GPa (K(i) = 57.8 +/- 7.1 micro m) and acts synergistically with glucose. To explore the molecular basis of E226 binding we have determined the crystal structure of the GPb/E226 complex at 2.3 A resolution. Structure analysis shows clearly that E226 binds at the purine inhibitor site, where caffeine and flavopiridol also bind [Oikonomakos, N.G., Schnier, J.B., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E. & Johnson, L.N. (2000) J. Biol. Chem.275, 34566-34573], by intercalating between the two aromatic rings of Phe285 and Tyr613. The mode of binding of E226 to GPb is similar, but not identical, to that of caffeine and flavopiridol. Comparative structural analyses of the GPb-E226, GPb-caffeine and GPb-flavopiridol complex structures reveal the structural basis of the differences in the potencies of the three inhibitors and indicate binding residues in the inhibitor site that can be exploited to obtain more potent inhibitors. Structural comparison of the GPb-E226 complex structure with the active pCDK2-cyclin A-E226 complex structure clearly shows the different binding modes of the ligand to GPb and CDK2; the more extensive interactions of E226 with the active site of CDK2 may explain its higher affinity towards the latter enzyme. PMID:15153119

  7. Corporate system of monitoring network informational resources based on agent-based approach

    OpenAIRE

    Lande, D. V.; Dodonov, V. A.; T V Kovalenko

    2016-01-01

    The paper provides a agent-based model, which describes distribution of informative messages, containing links to informational resources in the Internet. The results of modeling have been confirmed by studying a real network of Twitter microblogs. The paper describes stages of building a corporate system of monitoring network informational resources, the content of which is determined by links in microblogs. The advantages of such approach are set forth.

  8. Policy based Agents in Wireless Body Sensor Mesh Networks for Patient Health Monitoring

    Directory of Open Access Journals (Sweden)

    Kevin Miller

    2009-12-01

    Full Text Available There is presently considerable research interest in using wireless and mobile technologies in patient health monitoring particularly in hospitals and nursing homes. For health monitoring,, an intelligent agent based hierarchical architecture has already been published by one of the authors of this paper. Also, the technique of monitoring and notifying the health of patients using an intelligent agent, to the concerned hospital personnel, has also been proposed. We now present the details of the functioning of four main intelligent agents, viz., the nurse agent, the sensor agent, the database agent and the ward boy agent, for intimating the health information to the concerned doctor in the hospital, based on certain policies relevant to the hospital. The policies, in our case have been worked out based on the temperature parameter monitored by the “nurse agent”. We have considered just as an example, the physiological parameter viz., the body temperature monitoring, for our policy based agent implementation. The implementation has been carried out using JADE-LEAP agent development kit. The details are presented in the paper.

  9. A Novel Agent Based Approach for Controlling Network Storms

    CERN Document Server

    Nair, Dr T R Gopalakrishnan; M, Vaidehi

    2011-01-01

    One of the fundamental data transmission mechanisms in Ethernet LAN is broadcasting. Flooding is a direct broadcasting technique used in these networks. A significant drawback of this method is that it can lead to broadcast storms. This phenomenon is more common in multivendor switch environment. Broadcast storms usually results in dissension, collision and redundancy leading to degradation of the network performance. Most of the storms appear without much warning and it affects the efficiency of network even in situations when the network is expected to work most efficiently. There are several characteristic patterns by which storm can appear in a LAN, like rate monotonic repetition, transient appearances with different types of growth properties and decay profiles. In this paper we discuss the storm build up pattern in an industry and present various reasons for storm in LAN. We have identified a strategy for controlling network storms, using multiple static agents. These agents inhibit storm packet regener...

  10. Minority persistence in agent based model using information and emotional arousal as control variables

    Science.gov (United States)

    Sobkowicz, Pawel

    2013-07-01

    We present detailed analysis of the behavior of an agent based model of opinion formation, using a discrete variant of cusp catastrophe behavior of single agents. The agent opinion about a particular issue is determined by its information about the issue and its emotional arousal. It is possible that for agitated agents the same information would lead to different opinions. This results in a nontrivial individual opinion dynamics. The agents communicate via messages, which allows direct application of the model to ICT based communities. We study the dependence of the composition of an agent society on the range of interactions and the rate of emotional arousal. Despite the minimal number of adjustable parameters, the model reproduces several phenomena observed in real societies, for example nearly perfectly balanced results of some highly contested elections or the fact that minorities seldom perceive themselves to be a minority.

  11. Impulsive observer-based consensus control for multi-agent systems with time delay

    Science.gov (United States)

    Qin, Wen; Liu, Zhongxin; Chen, Zengqiang

    2015-09-01

    The paper deals with the distributed consensus problem of a class of general linear multi-agent systems with time delay. Assuming that the state of the multi-agent system cannot be measured and the output of the multi-agent system is measured discontinuously, a novel impulsive observer is constructed. Based on the impulsive observer, a distributed consensus protocol is proposed for the multi-agent system with a directed communication topology. In view of the hybrid characteristic of the multi-agent system with the impulsive observer, a novel type of piecewise Lyapunov functional which can overcome the jump phenomena at impulsive times is introduced. Based on this, some sufficient conditions in terms of linear matrix inequalities are presented such that the consensus of the multi-agent system can be achieved with an exponential convergence rate. A numerical example under two cases is given to show the effectiveness of the theoretical results.

  12. FINGERPRINT-BASED KEY BINDING/RECOVERING SCHEME BASED ON FUZZY VAULT

    Institute of Scientific and Technical Information of China (English)

    Feng Quan; Su Fei; Cai Anni

    2008-01-01

    This letter proposes fingerprint-based key binding/recovering with fuzzy vault. Fingerprint minutiae data and the cryptographic key are merged together by a multivariable linear function. First,the minutiae data are bound by a set of random data through the linear function. The number of the function's variables is determined by the required number of matched minutiae. Then, a new key derived from the random data is used to encrypt the cryptographic key. Lastly, the binding data are protected using fuzzy vault scheme. The proposed scheme provides the system with the flexibility to use changeable number of minutiae to bind/recover the protected key and a unified method regardless of the length of the key.

  13. Robot soccer simulation competition platform based on multi-agent

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Presents the robot soccer software simulation platform to be firstly used at FIRA Robot World Cup China 2001, introduces the system's purpose and design plan; discusses the system core-server configuration and working principle; describes the operating method and how to develop competition strategy, and refers to the teams to take part in FIRA Robot World Cup China 2001 and investigators who are interested in the distribu ted multi-agent system.

  14. Design of an Agent Based Traffic-Information Collection System

    OpenAIRE

    Kenedy Aliila Greyson

    2012-01-01

    Currently, traffic congestions are common events in road networks of main cities in developing countries. It has been observed that, the size of congestion increases year after year. For traffic congestion management to work efficiently, sufficiently and accurately information are needed. In this research we present an alternative method using agent technology to collect and manipulate data so as to be used in optimizing the vehicle flow within the road networks. The objective is to design an...

  15. NEW PRETANNING AGENTS BASED ON VALORIZATION OF INDUSTRIAL WASTES

    OpenAIRE

    M. Crudu; Deselnicu, V.; Ioannidis, I; A. Crudu

    2012-01-01

    Leather industry has to cope nowadays with major environmental problems because of the polluting processes (a World Bank report has placed the leather industry in the ninth place when considering theenvironmental impact).Therefore, increasing the environmental efficiency in the leather sector is the major aim of leather, auxiliary materials and equipment manufacturers. The development of new tanning agents is required to cope with the increasingly higher environmental pressure on the current ...

  16. Agent-Based Process-Critiquing Decision Support Systems

    Czech Academy of Sciences Publication Activity Database

    Bošanský, Branislav; Lhotská, L.

    Bratislava: Slovak Technical University, 2009, s. 1-6. [ISABEL 2009. International Symposium on Applied Sciences in Biomedical and Communication Technologies /2./. Bratislava (SK), 24.12.2009-27.12.2009] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : critiquing decision support system * multi-agent system * process * medical guidelines Subject RIV: IN - Informatics, Computer Science

  17. Agent-Based Process-Critiquing Decision Support System

    Czech Academy of Sciences Publication Activity Database

    Bošanský, Branislav; Lhotská, L.

    Los Alamitos : IEEE Computer Society, 2009, s. 1-6. ISBN 978-1-4244-4640-7. [ISABEL 2009. International Symposium on Applied Sciences in Biomedical and Communication Technologies /2./. Bratislava (SK), 24.12.2009-27.12.2009] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : decision support system s * health care * multi - agent system s Subject RIV: EC - Immunology

  18. Ontology-based and Evolutionary Search for Computational Agents Schemes

    Czech Academy of Sciences Publication Activity Database

    Neruda, Roman

    Skokie : Knowledge System s Institute Graduate School, 2008, s. 569-572. ISBN 1-891706-22-5. [SEKE 2008. International Conference on Software Engineering and Knowledge Engineering /20./. San Francisco (US), 01.07.2008-03.07.2008] R&D Projects: GA AV ČR 1ET100300419 Institutional research plan: CEZ:AV0Z10300504 Keywords : evolutionary algorithms * ontology * intelligent agent s Subject RIV: IN - Informatics, Computer Science

  19. EDM COLLABORATIVE MANUFACTURING SYSTEM BASED ON MULTI-AGENT TECHNIQUES

    Institute of Scientific and Technical Information of China (English)

    Zhao Wansheng; Zhao Jinzhi; Song Yinghui; Yang Xiaodong

    2003-01-01

    A framework for building EDM collaborative manufacturing system using multi-agent technology to support organizations characterized by physically distributed, enterprise-wide, heterogeneous intelligent manufacturing system over Internet is proposed. Expert system theory is introduced.Design, manufacturing and technological knowledge are shared using artificial intelligence and web techniques by EDM-CADagent, EDM-CAMagent and EDM-CAPPagent. System structure, design process, network conditions, realization methods and other key techniques are discussed. Instances are also introduced to testify feasibility.

  20. First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.

    Science.gov (United States)

    Purushottamachar, Puranik; Khandelwal, Aakanksha; Chopra, Pankaj; Maheshwari, Neha; Gediya, Lalji K; Vasaitis, Tadas S; Bruno, Robert D; Clement, Omoshile O; Njar, Vincent C O

    2007-05-15

    A qualitative 3D pharmacophore model (a common feature based model or Catalyst HipHop algorithm) was developed for well-known natural product androgen receptor down-regulating agents (ARDAs). The four common chemical features identified included: one hydrophobic group, one ring aromatic group, and two hydrogen bond acceptors. This model served as a template in virtual screening of the Maybridge and NCI databases that resulted in identification of six new ARDAs (EC(50) values 17.5-212 microM). Five of these molecules strongly inhibited the growth of human prostate LNCaP cells. These novel compounds may be used as leads to develop other novel anti-prostate cancer agents. PMID:17383188

  1. Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent

    Directory of Open Access Journals (Sweden)

    Liu W

    2015-07-01

    Full Text Available Wei Liu,1,* Jin-Feng Ning,2,* Qing-Wei Meng,1 Jing Hu,1 Yan-Bin Zhao,1 Chao Liu,3 Li Cai11The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, 2The Thoracic Surgery Department, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 3General Surgery Department, Mudanjiang Guanliju Central Hospital, Mishan, Heilongjiang Province, People’s Republic of China*These authors contributed equally to this workAbstract: The epidermal growth factor receptor (EGFR family has been validated as a successful antitumor drug target for decades. Known EGFR inhibitors were exposed to distinct drug resistance against the various EGFR mutants within non-small-cell lung cancer (NSCLC, particularly the T790M mutation. Although so far a number of studies have been reported on the development of third-generation EGFR inhibitors for overcoming the resistance issue, the design procedure largely depends on the intuition of medicinal chemists. Here we retrospectively make a detailed analysis of the 42 EGFR family protein crystal complexes deposited in the Protein Data Bank (PDB. Based on the analysis of inhibitor binding modes in the kinase catalytic cleft, we identified a potent EGFR inhibitor (compound A-10 against drug-resistant EGFR through fragment-based drug design. This compound showed at least 30-fold more potency against EGFR T790M than the two control molecules erlotinib and gefitinib in vitro. Moreover, it could exhibit potent HER2 inhibitory activities as well as tumor growth inhibitory activity. Molecular docking studies revealed a structural basis for the increased potency and mutant selectivity of this compound. Compound A-10 may be selected as a promising candidate in further preclinical studies. In addition, our findings could provide a powerful strategy to identify novel selective kinase inhibitors on the basis of detailed kinase–ligand interaction space in the PDB.Keywords: EGFR, kinase

  2. Evolution with Individual and Social Learning in an Agent-Based Stock Market

    OpenAIRE

    Yamamoto, Ryuichi

    2005-01-01

    Recent research has shown a variety of computational techniques to describe evolution in an artificial stock market. One can distinguish the techniques based on at which level the learning of agents is modeled. The previous literature describes learning at either individual or social level. The level of learning is exogenously given, and agents involve only a particular level of learning when they update their rules. But such a setting doesn’t say anything about why agents choose a particul...

  3. A Loosely Coupled Control Architecture Based on Agent and CORBA for Multiple Robots

    Institute of Scientific and Technical Information of China (English)

    Wu Shandong(吴山东); Chen Yimin; He Yongyi

    2003-01-01

    With the rapid development of information technology, adopting advanced distributed computing technology to construct robot control system is becoming an effective approach gradually. This paper proposes a distributed loosely coupled software architecture based on Agent and CORBA to control multiple robots. This model provides the robot user with agent control units at the semantic level and CORBA provides function interfaces to agent at the syntax level, which shows a good adaptability, flexibility and transparence.

  4. A Study of an Intelligent Battlefield Damage Assessment System Based on a Multi-agent System

    Institute of Scientific and Technical Information of China (English)

    LIU Xiang-kai; DAI Wan-jun; TANG Yan-feng; WANG Jia-ning

    2008-01-01

    Battlefield damage assessment is the key to Battlefield Damage Assessment and Repair (BDAR).We present an Intelligent Battlefield Damage Assessment System (IBDAS) based on multi-agent system technology. We first establish the system framework, and then study the interior structure and workflow of a problem allocation agent. The result shows that, there are many advantages to resolve the problem of battlefield damage assessment by applying multi-agent system technology, and it will bring significant military benefit.

  5. Consentaneous agent-based and stochastic model of the financial markets.

    Directory of Open Access Journals (Sweden)

    Vygintas Gontis

    Full Text Available We are looking for the agent-based treatment of the financial markets considering necessity to build bridges between microscopic, agent based, and macroscopic, phenomenological modeling. The acknowledgment that agent-based modeling framework, which may provide qualitative and quantitative understanding of the financial markets, is very ambiguous emphasizes the exceptional value of well defined analytically tractable agent systems. Herding as one of the behavior peculiarities considered in the behavioral finance is the main property of the agent interactions we deal with in this contribution. Looking for the consentaneous agent-based and macroscopic approach we combine two origins of the noise: exogenous one, related to the information flow, and endogenous one, arising form the complex stochastic dynamics of agents. As a result we propose a three state agent-based herding model of the financial markets. From this agent-based model we derive a set of stochastic differential equations, which describes underlying macroscopic dynamics of agent population and log price in the financial markets. The obtained solution is then subjected to the exogenous noise, which shapes instantaneous return fluctuations. We test both Gaussian and q-Gaussian noise as a source of the short term fluctuations. The resulting model of the return in the financial markets with the same set of parameters reproduces empirical probability and spectral densities of absolute return observed in New York, Warsaw and NASDAQ OMX Vilnius Stock Exchanges. Our result confirms the prevalent idea in behavioral finance that herding interactions may be dominant over agent rationality and contribute towards bubble formation.

  6. Influence of different liquid-drop-based bindings on lighter mass fragments and entropy production

    Science.gov (United States)

    Kumar, Rohit; Shivani; Gautam, Sakshi

    2016-04-01

    We study the production of lighter fragments and associated phenomena within the Quantum Molecular Dynamics (QMD) model. The Minimum Spanning Tree (MST) method is used to identify the pre-clusters. The final stable fragments were identified by imposing binding energy criteria on the fragments formed using the MST method. The effect of different binding energy criteria was investigated by employing various liquid-drop-based binding energy formulae. Though light clusters show significant effect of different binding energies, their associated phenomenon, i.e. entropy production is insensitive towards different binding energy criteria.

  7. DNABINDPROT: fluctuation-based predictor of DNA-binding residues within a network of interacting residues

    OpenAIRE

    Ozbek, Pemra; Soner, Seren; Erman, Burak; Haliloglu, Turkan

    2010-01-01

    DNABINDPROT is designed to predict DNA-binding residues, based on the fluctuations of residues in high-frequency modes by the Gaussian network model. The residue pairs that display high mean-square distance fluctuations are analyzed with respect to DNA binding, which are then filtered with their evolutionary conservation profiles and ranked according to their DNA-binding propensities. If the analyses are based on the exact outcome of fluctuations in the highest mode, using a conservation thre...

  8. An Intelligent Mobile-Agent Based Scalable Network Management Architecture for Large-Scale Enterprise System

    CERN Document Server

    Sharma, A K; Singh, Vijay

    2012-01-01

    Several Mobile Agent based distributed network management models have been proposed in recent times to address the scalability and flexibility problems of centralized (SNMP or CMIP management models) models. Though the use of Mobile Agents to distribute and delegate management tasks comes handy in dealing with the previously stated issues, many of the agent-based management frameworks like initial flat bed models and static mid-level managers employing mobile agents models cannot efficiently meet the demands of current networks which are growing in size and complexity. Moreover, varied technologies, such as SONET, ATM, Ethernet, DWDM etc., present at different layers of the Access, Metro and Core (long haul) sections of the network, have contributed to the complexity in terms of their own framing and protocol structures. Thus, controlling and managing the traffic in these networks is a challenging task. This paper presents an intelligent scalable hierarchical agent based model for the management of large-scal...

  9. Study on Multi Agent-Based Large Scope Distributed Software Architecture

    Institute of Scientific and Technical Information of China (English)

    WANGYinghui; LIUYu; ZHANGShikun

    2004-01-01

    Large scope distribution software technology will be a mainstream technology of software development for coming years. But Large scope distribution software development means high software complexity and expensive expenditure. Software architecture acts as blueprint of software system and turns into one of the determinant factor for development~ especially for large scope software in distribution environment. This paper analyzes the flexibility and suitability of software agent to construct LSSA (Large scope software architecture), then ADALSS(Agent-based distributed architecture of large scope software) based on agent federation is presented, and ADALSS mechanism is illustrated as well. Concerning implementation, a layer model of ADALSS based on interface is described. It will be a dominant pattern for future large scope software development to regard each agent as an object and to combine this agent object with ADALSS model.

  10. The Usability of Agent-Based Simulation in Decision Support System of E-Commerce Architecture

    Directory of Open Access Journals (Sweden)

    ŠPERKA Roman

    2012-02-01

    Full Text Available Electronic commerce (e-commerce has the potential to improve the competitiveness of the enterprises. A decision support system, used in e-commerce, is a term used to describe any software engine that enhances the user’s ability to make decisions. The paper presents a new approach for decision support system modeling. This approach is applied by a modification and extension of existing decision support system architecture by multi-agent technology and agent-based simulation models. Multi-agent technology is one of the fastest growing fields of information and communication technology – new agent-based services, products, and applications are being developed almost every day. Agent-based simulation model is applied to coordinate, control, and simulate the architecture of decision support system, used in e-commerce. The proposed architecture improves the existing decision support systems and gains competitive advantage.

  11. Between Complexity and Parsimony: Can Agent-Based Modelling Resolve the Trade-off

    DEFF Research Database (Denmark)

    Nielsen, Helle Ørsted; Malawska, Anna Katarzyna

    2013-01-01

    to BR- based policy studies would be to couple research on bounded ra-tionality with agent-based modeling. Agent-based models (ABMs) are computational models for simulating the behavior and interactions of any number of decision makers in a dynamic system. Agent-based models are better suited than...... with regards to behavioral rules. Bounded rationality research therefore could ensure realistic modeling while the ABM approach enhances the predictive value of behavioral modeling. This paper thus discusses the promise and limitations of using agent-based models to advance the use of the bounded rationality......While Herbert Simon espoused development of general models of behavior, he also strongly advo-cated that these models be based on realistic assumptions about humans and therefore reflect the complexity of human cognition and social systems (Simon 1997). Hence, the model of bounded rationality...

  12. A computational-intelligence-based optimization of agents' initial positions in land combat simulation

    Institute of Scientific and Technical Information of China (English)

    WU Chunguo; LIANG Yanchun; GE Hongwei; CAO Lijuan; LEE Heow Pueh

    2003-01-01

    The optimization of agents' initial properties enables agents to perform their assigned tasks more perfectly. This paper presents an optimizing method using the combination of radial basis function (RBF) neural network and genetic algorithm (GA). In the land combat simulation, the method can ensure that the agents optimized defeat the agents not optimized absolutely. Compared with the optimization based on support vector machines (SVM), the proposed method improves the efficiency more than twenty times, so it suits the cases where the speed as well as performance is required.

  13. Design of AgentX in SNMP-based SDH management network

    Science.gov (United States)

    Liang, Xiaohong; Sun, Minghai; Feng, ChongXi

    2002-09-01

    Management network plays an important role in the SDH transport system. Adopting the management architecture of CMIP, traditional SDH management network is chiefly a subset of TMN. Although its management ability is powerful, it is complex to implement. Considering not only the SNMP's simplicity and low resource consumption but also the flexible extensibility brought by the application of the extensible agent (AgentX) architecture, a different strategy of the SDH management network based on the SNMP management structure with AgentX is proposed in this paper. The design scheme of AgentX in the system is discussed further.

  14. Agent-based simulation of a Marine Infantry Squad in an urban environment

    OpenAIRE

    Aragon, Arthur R.

    2001-01-01

    This thesis research focused on the design, development and implementation of an agent based simulation of a Marine infantry squad in an urban environment. The goal was to design an autonomous-agent framework that could model a combatantαs decision cycle. A squad entity comprised of these agents was created to explore the idea of team dynamics and the balance between meeting individual goals and team goals. The agents were placed in a two-dimensional, discrete-state, simulation world with a ...

  15. Web based parallel/distributed medical data mining using software agents

    Energy Technology Data Exchange (ETDEWEB)

    Kargupta, H.; Stafford, B.; Hamzaoglu, I.

    1997-12-31

    This paper describes an experimental parallel/distributed data mining system PADMA (PArallel Data Mining Agents) that uses software agents for local data accessing and analysis and a web based interface for interactive data visualization. It also presents the results of applying PADMA for detecting patterns in unstructured texts of postmortem reports and laboratory test data for Hepatitis C patients.

  16. Learning Natural Selection in 4th Grade with Multi-Agent-Based Computational Models

    Science.gov (United States)

    Dickes, Amanda Catherine; Sengupta, Pratim

    2013-01-01

    In this paper, we investigate how elementary school students develop multi-level explanations of population dynamics in a simple predator-prey ecosystem, through scaffolded interactions with a multi-agent-based computational model (MABM). The term "agent" in an MABM indicates individual computational objects or actors (e.g., cars), and these…

  17. High performance computing for three-dimensional agent-based molecular models.

    Science.gov (United States)

    Pérez-Rodríguez, G; Pérez-Pérez, M; Fdez-Riverola, F; Lourenço, A

    2016-07-01

    Agent-based simulations are increasingly popular in exploring and understanding cellular systems, but the natural complexity of these systems and the desire to grasp different modelling levels demand cost-effective simulation strategies and tools. In this context, the present paper introduces novel sequential and distributed approaches for the three-dimensional agent-based simulation of individual molecules in cellular events. These approaches are able to describe the dimensions and position of the molecules with high accuracy and thus, study the critical effect of spatial distribution on cellular events. Moreover, two of the approaches allow multi-thread high performance simulations, distributing the three-dimensional model in a platform independent and computationally efficient way. Evaluation addressed the reproduction of molecular scenarios and different scalability aspects of agent creation and agent interaction. The three approaches simulate common biophysical and biochemical laws faithfully. The distributed approaches show improved performance when dealing with large agent populations while the sequential approach is better suited for small to medium size agent populations. Overall, the main new contribution of the approaches is the ability to simulate three-dimensional agent-based models at the molecular level with reduced implementation effort and moderate-level computational capacity. Since these approaches have a generic design, they have the major potential of being used in any event-driven agent-based tool. PMID:27372059

  18. Communication Model for a Process Planning System Based on a Multi-agent

    Institute of Scientific and Technical Information of China (English)

    WANG Tao; DU Juan; WANG Chun-yan; LI Yun-xia

    2012-01-01

    This paper introduces a process planning system communication model based on a Multi-agent and all levels of the communication process are in described in detail. The KQML( Knowledge Query and Manipulation Language) language communication is introduced emphatically using the communication performatives of the KQML language to achieve communication between the agents among the process planning.

  19. Lapse of time effects on tax evasion in an agent-based econophysics model

    Science.gov (United States)

    Seibold, Götz; Pickhardt, Michael

    2013-05-01

    We investigate an inhomogeneous Ising model in the context of tax evasion dynamics where different types of agents are parameterized via local temperatures and magnetic fields. In particular, we analyze the impact of lapse of time effects (i.e. backauditing) and endogenously determined penalty rates on tax compliance. Both features contribute to a microfoundation of agent-based econophysics models of tax evasion.

  20. On the role of backauditing for tax evasion in an agent-based Econophysics model

    CERN Document Server

    Seibold, G

    2012-01-01

    We investigate an inhomogeneous Ising model in the context of tax evasion dynamics where different types of agents are parametrized via local temperatures and magnetic fields. In particular, we analyse the impact of backauditing and endogenously determined penalty rates on tax compliance. Both features contribute to a microfoundation of agent-based econophysics models of tax evasion.

  1. Cloud-based multi-agent architecture for effective planning and scheduling of distributed manufacturing

    DEFF Research Database (Denmark)

    Mishra, Nishikant; Singh, Akshit; Kumari, Sushma;

    2016-01-01

    this article, a self-reactive cloud-based multi-agent architecture for distributed manufacturing system is developed. The proposed architecture will assist manufacturing industry to establish real-time information exchange between the autonomous agents, clients, suppliers and manufacturing unit. The...

  2. Flocking in Multi-Agent Systems with Multiple Virtual Leaders Based Only on Position Measurements

    International Nuclear Information System (INIS)

    Most existing flocking algorithms assume one single virtual leader and rely on information on both relative positions and relative velocities among neighboring agents. In this paper, the problem of controlling a flock of mobile autonomous agents to follow multiple virtual leaders is investigated by using only position information in the sense that agents with the same virtual leader asymptotically attain the same velocity and track the corresponding virtual leader based on only position measurements. A flocking algorithm is proposed under which every agent asymptotically attains its desired velocity, collision between agents can be avoided, and the final tight formation minimizes all agents' global potentials. A simulation example is presented to verify and illustrate the theoretical results. (general)

  3. Agent-based simulations of emotion spreading in online social networks

    CERN Document Server

    Šuvakov, Milovan; Schweitzer, Frank; Tadić, Bosiljka

    2012-01-01

    Quantitative analysis of empirical data from online social networks reveals group dynamics in which emotions are involved (\\v{S}uvakov et al). Full understanding of the underlying mechanisms, however, remains a challenging task. Using agent-based computer simulations, in this paper we study dynamics of emotional communications in online social networks. The rules that guide how the agents interact are motivated, and the realistic network structure and some important parameters are inferred from the empirical dataset of \\texttt{MySpace} social network. Agent's emotional state is characterized by two variables representing psychological arousal---reactivity to stimuli, and valence---attractiveness or aversiveness, by which common emotions can be defined. Agent's action is triggered by increased arousal. High-resolution dynamics is implemented where each message carrying agent's emotion along the network link is identified and its effect on the recipient agent is considered as continuously aging in time. Our res...

  4. Reference model based consensus control of second-order multi-agent systems

    International Nuclear Information System (INIS)

    This paper deals with the consensus problem of multi-agent systems with second-order dynamics. The objective is to design algorithms such that all agents will have same positions and velocities. First, a reference model based consensus algorithm is proposed. It is proved that the consensus can be achieved if the communication graph has a spanning tree. Different from most of the consensus algorithms proposed in the literature, the parameters of the control laws are different among agents. Therefore, each agent can design its control law independently. Secondly, it gives a consensus algorithm for the case that the velocities of the agents are not available. Thirdly, the effectiveness of the input delay and the communication delay is considered. It shows that consensus can be achieved if the input delay of every agent is smaller than a bound related to parameters in its control law. Finally, some numerical examples are given to illustrate the proposed results. (general)

  5. Toward carbon nanotube-based imaging agents for the clinic.

    Science.gov (United States)

    Hernández-Rivera, Mayra; Zaibaq, Nicholas G; Wilson, Lon J

    2016-09-01

    Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, potential toxicity, therapeutic activity, and any physiological changes that the material may induce in specific tissues. There are many different imaging modalities to visualize and track CNTs in vivo, yet only a few are full-body penetrating, a central characteristic that widens their clinical utility. In order to visualize CNTs, chemical modification is often required for the material to be used as a platform to carry imaging agents compatible with one or more of the clinical imaging techniques. Here, we focus on the most recent work involving the use of CNTs as imaging agents for the non-invasive, full-body penetrating clinical modalities of MRI, PET, SPECT, and X-ray CT. The synthesis and modification of the CNT materials are discussed, as well as relevant preclinical studies. PMID:27294540

  6. Rapid detection of biothreat agents based on cellular machinery.

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Todd W.; Gantt, Richard W.

    2004-12-01

    This research addresses rapid and sensitive identification of biological agents in a complex background. We attempted to devise a method by which the specificity of the cellular transcriptional machinery could be used to detect and identify bacterial bio-terror agents in a background of other organisms. Bacterial cells contain RNA polymerases and transcription factors that transcribe genes into mRNA for translation into proteins. RNA polymerases in conjunction with transcription factors recognize regulatory elements (promoters) upstream of the gene. These promoters are, in many cases, recognized by the polymerase and transcription factor combinations of one species only. We have engineered a plasmid, for Escherichia coli, containing the virA promoter from the target species Shigella flexneri. This promoter was fused to a reporter gene Green Fluorescent Protein (GFP). In theory the indicator strain (carrying the plasmid) is mixed with the target strain and the two are lysed. The cellular machinery from both cells mixes and the GFP is produced. This report details the results of testing this system.

  7. Nanoparticle-Based Electrochemical Immunosensor for the Detection of Phosphorylated Acetylcholinesterase: An Exposure Biomarker of Organophosphate Pesticides and Nerve AgentsOrganophosphate Pesticides and Nerve Agents

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Guodong; Wang, Jun; Barry, Richard C.; Petersen, Catherine E.; Timchalk, Charles; Gassman, Paul L.; Lin, Yuehe

    2008-11-01

    A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE) adducts, which is a potential exposure biomarker for organophosphate pesticides (OP) and chemical warfare nerve agent exposures. Zirconia nanoparticles (ZrO2 NPs) were used as selective sorbents to capture the phosphorylated AChE adduct, and quantum dots (ZnS@CdS, QDs) were used as tags to label monoclonal anti-AChE antibody to track the immunorecognition events. The sandwich-like immunoreactions were performed among the ZrO2 NPs, which were pre-coated on a screen printed electrode (SPE) by electrodeposition, phosphorylated AChE and QD-anti-AChE. The captured QD tags were determined on the SPE by electrochemical stripping analysis of its metallic component (cadmium) after an acid-dissolution step. Paraoxon was used as a model OP insecticide to prepare the phosphorylated AChE adduct to demonstrate the proof of principle for this sensor technology. The paraoxon-AChE adduct was characterized by Fourier Transform Infrared Spectrum, and the binding affinity of anti-AChE to the paraoxon-AChE was validated with an enzyme-linked immunosorbent assay. The parameters (e.g., amount of ZrO2 NP, QD-anti-AChE concentration,) that govern the electrochemical response of immunosensors were optimized. The voltammetric response of the immunosensor is highly linear over the range of 10 pM to 4 nM paraoxon-AChE, and the limit of detection is estimated to be 8 pM. This new nanoparticle-based electrochemical immunosensor thus provides a sensitive and quantitative tool for biomonitoring exposure to OP pesticides and nerve agents.

  8. Getting away from numbers: Using qualitative observation for agent-based modeling

    OpenAIRE

    Yang, L; Gilbert, N.

    2008-01-01

    Although in many social sciences there is a radical division between studies based on quantitative (e.g. statistical) and qualitative (e.g. ethnographic) methodologies and their associated epistemological commitments, agent-based simulation fits into neither camp, and should be capable of modelling both quantitative and qualitative data. Nevertheless, most agent-based models (ABMs) are founded on quantitative data. This paper explores some of the methodological and practical problems involved...

  9. Using Hybrid Agent-Based Systems to Model Spatially-Influenced Retail Markets

    OpenAIRE

    Alison Heppenstall; Andrew Evans; Mark Birkin

    2006-01-01

    One emerging area of agent-based modelling is retail markets; however, there are problems with modelling such systems. The vast size of such markets makes individual-level modelling, for example of customers, difficult and this is particularly true where the markets are spatially complex. There is an emerging recognition that the power of agent-based systems is enhanced when integrated with other AI-based and conventional approaches. The resulting hybrid models are powerful tools that combine...

  10. Effects of beta-adrenergic blocking agents on specific binding of [3H]D-Ala2-Met5-enkephalinamide and [3H]naloxone.

    OpenAIRE

    Takayama, Haruhiko; Ogawa,Norio; Asanuma, Masato; Hirata, Hiroshi; Ogura,Toshio; Ota,Zensuke

    1991-01-01

    To gain further insight into the central nervous system (CNS)-action of beta-adrenergic blocking agents (beta-blockers), we examined the effects of various kinds of beta-blockers on opioid receptors (Op-Rs) using radiolabeled receptor assay (RRA). We demonstrated that beta-blockers are competitively bound to Op-Rs in the CNS. Sodium index of beta-blockers in [3H]naloxone binding study indicated that beta-blockers had the mixed agonist-antagonist activity of opiates. The relative potency of be...

  11. Integrated Information Framework for Intelligent Cooperative Design Based on Multi-Agent System and XML

    Science.gov (United States)

    Yan, Cao; Lina, Yang; Yanli, Yang; Hua, Chen

    2008-11-01

    To meet the requirements of distributed cooperation in various industries, the architecture of cooperative design based on multi-agent system on Internet is proposed by analyzing cooperative design pattern, and its key technologies, such as product developing process management, information management, and conflict resolution, are discussed. An integrated information framework of loosely coupling modules is proposed which supports concurrent work mode based on multi-agent system. Integrating Web service technique and agent technique into this framework can organize many cooperative members and their activities effectively though they are distributed at different places. Finally, system development mode based on Web is put forward.

  12. STUDIES ON HORIZONTAL COMPETITION AMONG HOMOGENOUS RETAILERS THROUGH AGENT-BASED SIMULATION

    Institute of Scientific and Technical Information of China (English)

    Ming XIE; Jian CHEN

    2004-01-01

    This paper adopts agent-based simulation to study the horizontal competition among homogenous price-setting retailers in a one-to-many supply chain (a supply chain consists of one supplier and multiple retailers). We model the supplier and retailers as agents, and design their behavioral rulesrespectively. The results show that although the agents learn individually based on their own experiences, the system converges asymptotically to near Nash equilibrium steady states.When analyzing the results, we first discuss the properties of these steady states. Then based on these properties, we analyze the effects of the retailers' horizontal competition on the retail prices, retailers'profits and supplier's revenue.

  13. Brief introductory guide to agent-based modeling and an illustration from urban health research.

    Science.gov (United States)

    Auchincloss, Amy H; Garcia, Leandro Martin Totaro

    2015-11-01

    There is growing interest among urban health researchers in addressing complex problems using conceptual and computation models from the field of complex systems. Agent-based modeling (ABM) is one computational modeling tool that has received a lot of interest. However, many researchers remain unfamiliar with developing and carrying out an ABM, hindering the understanding and application of it. This paper first presents a brief introductory guide to carrying out a simple agent-based model. Then, the method is illustrated by discussing a previously developed agent-based model, which explored inequalities in diet in the context of urban residential segregation. PMID:26648364

  14. Brief introductory guide to agent-based modeling and an illustration from urban health research

    Directory of Open Access Journals (Sweden)

    Amy H. Auchincloss

    2015-11-01

    Full Text Available Abstract There is growing interest among urban health researchers in addressing complex problems using conceptual and computation models from the field of complex systems. Agent-based modeling (ABM is one computational modeling tool that has received a lot of interest. However, many researchers remain unfamiliar with developing and carrying out an ABM, hindering the understanding and application of it. This paper first presents a brief introductory guide to carrying out a simple agent-based model. Then, the method is illustrated by discussing a previously developed agent-based model, which explored inequalities in diet in the context of urban residential segregation.

  15. Multi-agent based decision Support System using Data Mining and Case Based Reasoning

    Directory of Open Access Journals (Sweden)

    S Srinivasan

    2011-07-01

    Full Text Available A knowledge-based society determines organizations to focus their activities on improving management quality by using knowledge. Huge data stores become important once the real significance of data is discovered. Data mining techniques are involved in different knowledge processes, as one can notice in various public applications of the researchers. Managers can use these techniques in order to extract patterns, relations, associations from data initially considered of little value. Over the past decade, case-based reasoning (CBR has emerged as a major research area within the artificial intelligence research field due to both its widespread usage by humans and its appeal as a methodology for building intelligent systems. More recently, there has been a search for new paradigms and directions for increasing the utility of CBR systems for decision support. This paper focuses on the synergism between the research areas of Data Mining, CBR System, Multi-agent System and decision support systems (DSSs. A conceptual framework for DSSs based on MAS using DM and CBRS is presented. Nowadays, intelligent agents represent an important opportunity to optimize knowledge management. The research implications of the evolution in the design of DSS based on MAS using DM and CBR systems from automation toward decision-aiding is also explored.

  16. Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array.

    Science.gov (United States)

    Worstell, Nolan C; Krishnan, Pratik; Weatherston, Joshua D; Wu, Hung-Jen

    2016-01-01

    Protein-glycan recognition is often mediated by multivalent binding. These multivalent bindings can be further complicated by cooperative interactions between glycans and individual glycan binding subunits. Here we have demonstrated a nanocube-based lipid bilayer array capable of quantitatively elucidating binding dissociation constants, maximum binding capacity, and binding cooperativity in a high-throughput format. Taking cholera toxin B subunit (CTB) as a model cooperativity system, we studied both GM1 and GM1-like gangliosides binding to CTB. We confirmed the previously observed CTB-GM1 positive cooperativity. Surprisingly, we demonstrated fucosyl-GM1 has approximately 7 times higher CTB binding capacity than GM1. In order to explain this phenomenon, we hypothesized that the reduced binding cooperativity of fucosyl-GM1 caused the increased binding capacity. This was unintuitive, as GM1 exhibited higher binding avidity (16 times lower dissociation constant). We confirmed the hypothesis using a theoretical stepwise binding model of CTB. Moreover, by taking a mixture of fucosyl-GM1 and GM2, we observed the mild binding avidity fucosyl-GM1 activated GM2 receptors enhancing the binding capacity of the lipid bilayer surface. This was unexpected as GM2 receptors have negligible binding avidity in pure GM2 bilayers. These unexpected discoveries demonstrate the importance of binding cooperativity in multivalent binding mechanisms. Thus, quantitative analysis of multivalent protein-glycan interactions in heterogeneous glycan systems is of critical importance. Our user-friendly, robust, and high-throughput nanocube-based lipid bilayer array offers an attractive method for dissecting these complex mechanisms. PMID:27070150

  17. AGENT BASED PUBLIC AUDIT FOR SECURED CLOUD STORAGE

    Directory of Open Access Journals (Sweden)

    Vinod Kumar Pal

    2015-10-01

    Full Text Available Operating system kernels typically enforce lowest restrictions on the applications permissible to execute leading to the power of malicious programs to abuse system resources. Malware running as standalone processes will freely execute enjoying the privileges provided to the user account running the method. Main stream software package kernels lack a robust and reliable mechanism for distinctive the running processes and binding them to the corresponding possible applications. Method authentication is completely different from method identification. Our supervisor call instruction observances are often integrated with existing obligatory access management systems to enforce application-level access rights. We tend to address the identification downside by proposing a unique secure application identification model within which user-level applications square measure needed to gift identification proofs at run time to be genuine to the kernel. Our supervisor call instruction observance is often integrated with existing obligatory access management systems to enforce application-level access rights.

  18. Stylized facts from a threshold-based heterogeneous agent model

    CERN Document Server

    Cross, R; Lamba, H; Seaman, T

    2006-01-01

    A class of heterogeneous agent models is investigated where investors switch trading position whenever their motivation to do so exceeds some critical threshold. These motivations can be psychological in nature or reflect behaviour suggested by the efficient market hypothesis (EMH). By introducing different propensities into a baseline model that displays EMH behaviour, one can attempt to isolate their effects upon the market dynamics. The simulation results indicate that the introduction of a herding propensity results in excess kurtosis and power-law decay consistent with those observed in actual return distributions, but not in significant long-term volatility correlations. Possible alternatives for introducing such long-term volatility correlations are then identified and discussed.

  19. AGENTS BASED ADAPTIVE HYPERMEDIA SYSTEM WITH THE COMPETENCY APPROACH

    Directory of Open Access Journals (Sweden)

    Jose Sergio Magdaleno-Palencia

    2011-01-01

    Full Text Available This work is motivated by the need to propose a model for the study of personalized hypermedia systems with a competency approach, which is one of United Nations Educational, Scientific and Cultural Organization (UNESCO and General Administration of Higher Education Technology (DGEST recommendations. We use computer agents, to construct a student model with emphasis on his learning style, multiple intelligences and the competency evaluation to adapt the course material according to the student’s needs. The system will also use artificial intelligence techniques. The systems will be used at a university level; the primary goal is to help each student learn and thus reach a suitable competency level.

  20. Building an Agent-Based Laboratory Infrastructure for Higher Education

    Directory of Open Access Journals (Sweden)

    Muna Saqer

    2009-08-01

    Full Text Available We present an ongoing project at the University of Houston- Downtown (UHD that aims to build a grid as a laboratory environment to support undergraduate education. We intend to use this PC clusters centered grid to allow students to perform laboratory exercises through web interfaces. In order to accommodate lab packages of a growing number of courses, we design the system as a modular system using multi-agent modeling. Students are recruited to implement the units of the system as senior student project topics or research activities sponsored by the Scholar's Academy of UHD. Through these projects, we geared our research toward higher education and provided students with opportunities to participate in building a computational infrastructure for curriculum improvement. This is very important for a minority-serving institution (MSI with limited resources such as UHD.

  1. Stylized facts from a threshold-based heterogeneous agent model

    Science.gov (United States)

    Cross, R.; Grinfeld, M.; Lamba, H.; Seaman, T.

    2007-05-01

    A class of heterogeneous agent models is investigated where investors switch trading position whenever their motivation to do so exceeds some critical threshold. These motivations can be psychological in nature or reflect behaviour suggested by the efficient market hypothesis (EMH). By introducing different propensities into a baseline model that displays EMH behaviour, one can attempt to isolate their effects upon the market dynamics. The simulation results indicate that the introduction of a herding propensity results in excess kurtosis and power-law decay consistent with those observed in actual return distributions, but not in significant long-term volatility correlations. Possible alternatives for introducing such long-term volatility correlations are then identified and discussed.

  2. Simulation of Service Supply Chain Formation Based on Mobile Agent

    Institute of Scientific and Technical Information of China (English)

    YANG Zhe; ZHANG Da-lu; XU Jian

    2005-01-01

    In E-Commerce, consumers and service suppliers can find the services through the searching of Mobile Agents (MA).The suppliers disassemble the service requests of consumers into the sub-requests. Then suppliers respond the subrequests cooperatively. Thus the Service Supply Chain(SSC) can be formed. But the existing bottom-up and upbottom supply chain formation fashions cannot be adapted to the SSC in distributed environment of E-Commerce. Task Dependency Network is exploited to illustrate the service relationship among consumers and suppliers. The formation of SSC with some simulations is elaborated. Then the influence on the formation of SSC caused by the type of service suppliers, the quantities of MA and its variety in number is elucidated.

  3. An agent-based model of collective emotions in online communities

    Science.gov (United States)

    Schweitzer, F.; Garcia, D.

    2010-10-01

    We develop an agent-based framework to model the emergence of collective emotions, which is applied to online communities. Agent’s individual emotions are described by their valence and arousal. Using the concept of Brownian agents, these variables change according to a stochastic dynamics, which also considers the feedback from online communication. Agents generate emotional information, which is stored and distributed in a field modeling the online medium. This field affects the emotional states of agents in a non-linear manner. We derive conditions for the emergence of collective emotions, observable in a bimodal valence distribution. Dependent on a saturated or a superlinear feedback between the information field and the agent’s arousal, we further identify scenarios where collective emotions only appear once or in a repeated manner. The analytical results are illustrated by agent-based computer simulations. Our framework provides testable hypotheses about the emergence of collective emotions, which can be verified by data from online communities.

  4. Software Cost Estimation Model Based on Integration of Multi-agent and Case-Based Reasoning

    Directory of Open Access Journals (Sweden)

    Hasan Al-Sakran

    2006-01-01

    Full Text Available Accurate software cost estimation is a vital task that affects the firm's software investment decisions before committing required resources to that project or bidding for a contract. This study proposes an improved Case-Based Reasoning (CBR approach integrated with multi-agent technology to retrieve similar projects from multi-organizational distributed datasets. The study explores the possibility of building a software cost estimation model by collecting software cost data from distributed predefined project cost databases. The model applying CBR method to find similar projects in historical data derived from measured software projects developed by different organizations.

  5. Modeling Multi-Mobile Agents System Based on Coalition Signature Mechanism Using UML

    Institute of Scientific and Technical Information of China (English)

    SUNZhixin; HUANGHaiping; WANGRuchuan

    2004-01-01

    With the development of electronic commerce and agent techniques, multi-mobile agents cooperation can not only improve the efficiency of electronic business trade, but more importantly, it has a comprehensive applicative value in solving the security issues of mobile agent system. This paper firstly describes the mechanism of multi-mobile agents coalition signature aiming at the system security. Subsequently it brings forward a basic architecture of Multi-mobile agents system (MMAS) based on the design pattern of multi-mobile agents. The paper uses the diagrs_rn of UML, such as use case diagram, class diagram and sequence diagram to build the detailed model of the coalition signature and multi-mobile agents cooperation results. Through security analysis, we find that multimobile agents cooperation and interaction can solve some security problems of mobile agents in transfer, and also it can improve the efficiency of business trade. These results indicate that MMAS has a high security performance and can be widely used in E-commerce trade.

  6. Emergence of a Snake-Like Structure in Mobile Distributed Agents: An Exploratory Agent-Based Modeling Approach

    Directory of Open Access Journals (Sweden)

    Muaz A. Niazi

    2014-01-01

    Full Text Available The body structure of snakes is composed of numerous natural components thereby making it resilient, flexible, adaptive, and dynamic. In contrast, current computer animations as well as physical implementations of snake-like autonomous structures are typically designed to use either a single or a relatively smaller number of components. As a result, not only these artificial structures are constrained by the dimensions of the constituent components but often also require relatively more computationally intensive algorithms to model and animate. Still, these animations often lack life-like resilience and adaptation. This paper presents a solution to the problem of modeling snake-like structures by proposing an agent-based, self-organizing algorithm resulting in an emergent and surprisingly resilient dynamic structure involving a minimal of interagent communication. Extensive simulation experiments demonstrate the effectiveness as well as resilience of the proposed approach. The ideas originating from the proposed algorithm can not only be used for developing self-organizing animations but can also have practical applications such as in the form of complex, autonomous, evolvable robots with self-organizing, mobile components with minimal individual computational capabilities. The work also demonstrates the utility of exploratory agent-based modeling (EABM in the engineering of artificial life-like complex adaptive systems.

  7. Practicality of Agent-Based Modeling of Civil Violence: an Assessment

    CERN Document Server

    Thron, Christopher

    2015-01-01

    Joshua Epstein (2002) proposed a simple agent-based model to describe the formation and evolution of spontaneous civil violence (such as riots or violent demonstrations). In this paper we study the practical applicability of Epstein's model.

  8. A Guide for Newcomers to Agent-Based Modeling in the Social Sciences

    OpenAIRE

    Axelrod, Robert; Tesfatsion, Leigh

    2006-01-01

    This guide provides pointers to introductory readings, software, and other materials to help newcomers become acquainted with agent-based modeling in the social sciences. Related work can be accessed at: http://www.econ.iastate.edu/tesfatsi/ace.htm

  9. Agent-Based Simulation and Assessment of NAS Security and Safety Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The key innovation proposed here is the use of agent-based modeling and simulation to evaluate the safety of the National Airspace under crisis operations and...

  10. Agent-based Social Simulation tools: Brahms and NetLogo

    NARCIS (Netherlands)

    Sie, Rory

    2010-01-01

    Sie, R. L. L. (2010, 21 September). Agent-based Social Simulation tools: Brahms and NetLogo. Presentation at the Learning Networks Plenary, Heerlen, The Netherlands: Open University of the Netherlands.

  11. Representing a Combat ID Analysis Tool within an Agent Based Constructive Simulation

    NARCIS (Netherlands)

    Dean, D.; Mistry, B.; Spaans, M.; Vincent, A.; Hossain, A.

    2009-01-01

    Motivation - This paper describes an approach for the development of a model which represents complex human factors relationships relating to Combat Identification (Combat ID). Research approach - The human factors relationships were incorporated within an experimental Agent Based Model (ABM), using

  12. Rediscovering the Economics of Keynes in an Agent-Based Computational Setting

    DEFF Research Database (Denmark)

    Bruun, Charlotte

    2016-01-01

    properties in common with what we today call complex dynamic systems, and we may apply the method of agent-based computational economics to his ideas. The presented agent-based Keynesian model demonstrates, as argued by Keynes, that the economy can self-organize without relying on price movement as an......The aim of this paper is to use agent-based computational economics to explore the economic thinking of Keynes. Taking his starting point at the macroeconomic level, Keynes argued that economic systems are characterized by fundamental uncertainty — an uncertainty that makes rule-based behavior and...... reliance on monetary magnitudes more optimal to the economic agent than profit — and utility optimization in the traditional sense. Unfortunately, more systematic studies of the properties of such a system were not possible at the time of Keynes. However, the system envisioned by Keynes holds a lot of...

  13. Rediscovering the Economics of Keynes in an Agent-Based Computational Setting

    DEFF Research Database (Denmark)

    Bruun, Charlotte

    commen with what we today call complex dynamic systems, and today we may aply the method of agent-based computational economics to the ideas of Keynes. The presented agent-based Keynesian model demonstrate, as argued by Keynes, that the economy can selforganize without relying on price movement as an......The aim of this paper is to use agent-based computational economics to explore the economic thinking of Keynes. Taking his starting point at the macroeconomic level, Keynes argued that economic systems are characterized by fundamental uncertainty - an uncertainty that makes rule-based behaviour and...... reliance on monetary magnitudes more optimal to the economic agent than profit- and utility optimazation in the traditional sense. Unfortunately more systematic studies of the properties of such a system was not possible at the time of Keynes. The system envisioned by Keynes holds a lot of properties in...

  14. Consensus of heterogeneous multi-agent systems based on sampled data with a small sampling delay

    International Nuclear Information System (INIS)

    In this paper, consensus problems of heterogeneous multi-agent systems based on sampled data with a small sampling delay are considered. First, a consensus protocol based on sampled data with a small sampling delay for heterogeneous multi-agent systems is proposed. Then, the algebra graph theory, the matrix method, the stability theory of linear systems, and some other techniques are employed to derive the necessary and sufficient conditions guaranteeing heterogeneous multi-agent systems to asymptotically achieve the stationary consensus. Finally, simulations are performed to demonstrate the correctness of the theoretical results. (interdisciplinary physics and related areas of science and technology)

  15. An agent based approach for simulating complex systems with spatial dynamicsapplication in the land use planning

    Directory of Open Access Journals (Sweden)

    Fatimazahra BARRAMOU

    2012-12-01

    Full Text Available In this research a new agent based approach for simulating complex systems with spatial dynamics is presented. We propose architecture based on coupling between two systems: multi-agent systems and geographic information systems. We also propose a generic model of agent-oriented simulation that we will apply to the field of land use planning. In fact, simulating the evolution of the urban system is a key to help decision makers to anticipate the needs of the city in terms of installing new equipment and opening new urbanization’ areas to install the new population.

  16. Techniques, Advantages and Problems of Agent Based Modeling for Traffic Simulation

    Directory of Open Access Journals (Sweden)

    Ali Bazghandi

    2012-01-01

    Full Text Available Agent-based modeling (ABM is a powerful simulation modeling technique in the last few years. ABM, as an approach to simulating the behavior of a complex system in which agents interact with each other and with their environment using simple local rules, is gaining popularity and widespread use in many areas. Successes of this approach in predicting traffic flow in metropolitan areas, the spread of infectious diseases, and the behavior of economic systems have generated further interest in this powerful technology. In this paper we focus on agent-based approach to traffic simulation, and investigate its benefits, difficulties and (microscopic-macroscopic techniques.

  17. Agent-Based Support for Collaborative Data Mining in Systems Management

    OpenAIRE

    Bordetsky, Alex

    2001-01-01

    Proceedings of the 34th Hawaii International Conference on System Sciences - 2001 This paper addresses the issues of structuring and supporting the collaborative data mining process. It extends the technology of multiparticipant decision making support into the data mining process and describes perspective agent-based support architecture for the data mining committees. The proposed architecture is based on the agents-facilitators integrated with layered structure of c...

  18. On the role of a librarian agent in ontology-based knowledge management systems.

    OpenAIRE

    Stojanovic, Nenad

    2007-01-01

    Abstract: In this paper, we present an agent-based approach for the improvement of searching in an ontology-based knowledge management system. The system implements a library scenario in which users query the repository for knowledge resources. Consequently, the so-called Librarian Agent plays the role of the human librarian in the traditional library – it uses all possible information, about the domain vocabulary, the behaviour of previous users and the capacity of the k...

  19. A Dynamic Cordon Pricing Scheme combining a Macroscopic and an Agent-based traffic Models

    OpenAIRE

    Zheng, Nan; Waraich, Rashid A.; Axhausen, Kay W.; Geroliminis, Nikolaos

    2012-01-01

    Pricing is considered an effective management policy to reduce traffic congestion in transportation networks. In this paper we combine a macroscopic model of traffic congestion in urban networks with an agent-based simulator to study congestion pricing schemes. The macroscopic model, which has been tested with real data in previous studies, represents an accurate and robust approach to model the dynamics of congestion. The agent-based simulator can reproduce the complexity of travel behavior ...

  20. An agent -based Intelligent System to enhance E-Learning through Mining Techniques

    OpenAIRE

    S.Prakasam; Prof.Dr.R.M.Suresh

    2010-01-01

    The growth of Internet has created new ways for education systems. Learners and teachers realize their pedagogic activities with less effort, time and money. Agent Based Intelligent System (ABIS) have proved their worth in multiple ways and in multiple domains in Education. In this paper the application of an agent-based IntelligentSystem for enhancing E-learning is introduced. An ABIS is a system that provides direct customized instruction or feedback to studentswithout the intervention of h...

  1. Agent-based land-use models: a review of applications

    OpenAIRE

    Matthews, RB; Gilbert, NG; Roach, A.; Polhill, JG; Gotts, NM

    2007-01-01

    Agent-based modelling is an approach that has been receiving attention by the land use modelling community in recent years, mainly because it offers a way of incorporating the influence of human decision-making on land use in a mechanistic, formal, and spatially explicit way, taking into account social interaction, adaptation, and decision-making at different levels. Specific advantages of agent-based models include their ability to model individual decision-making entities and their interact...

  2. An Agent-Based Focused Crawling Framework for Topic- and Genre-Related Web Document Discovery

    OpenAIRE

    Pappas, Nikolaos; Katsimpras, Georgios; Stamatatos, Efstathios

    2012-01-01

    The discovery of web documents about certain topics is an important task for web-based applications including web document retrieval, opinion mining and knowledge extraction. In this paper, we propose an agent-based focused crawling framework able to retrieve topic- and genre-related web documents. Starting from a simple topic query, a set of focused crawler agents explore in parallel topic-specific web paths using dynamic seed URLs that belong to certain web genres and are collected from web...

  3. The Third Way of Agent-Based Social Simulation and a Computational Account of Emergence

    OpenAIRE

    Roy Wilson

    2010-01-01

    This paper interprets a particular agent-based social simulation (ABSS) in terms of the third way of understanding agent-based simulation proposed by Conte. It is proposed that the normalized compression distance (derived from estimates of Kolmogorov complexity) between the initial and final macrolevel states of the ABSS provides a quantitative measure of the degree to which the results obtained via the ABSS might be obtained via a closed-form expression. If the final macrolevel state of an A...

  4. Agent-based modeling: Methods and techniques for simulating human systems

    OpenAIRE

    Bonabeau, Eric

    2002-01-01

    Agent-based modeling is a powerful simulation modeling technique that has seen a number of applications in the last few years, including applications to real-world business problems. After the basic principles of agent-based simulation are briefly introduced, its four areas of application are discussed by using real-world applications: flow simulation, organizational simulation, market simulation, and diffusion simulation. For each category, one or several business applications are described ...

  5. An Agent-Based Model of Behavior in “Beauty Contest” Games

    OpenAIRE

    Nichols, Mark W.; Michael J. Radzicki

    2007-01-01

    Recently, computer simulation, particularly agent-based modeling, has grown in popularity as a method to uncover macro patterns and developments that emerge from simple micro behavior. The present paper combines both techniques by using protocol analysis to uncover player strategies in an experiment and encoding those strategies in an agent-based computer simulation. In particular, Keynes’ (1936) beauty contest analogy is simulated in a number-guessing context. Several researchers have conduc...

  6. Comparing Stochastic Differential Equations and Agent-Based Modelling and Simulation for Early-Stage Cancer

    OpenAIRE

    Figueredo, Grazziela P.; Peer-Olaf Siebers; Owen, Markus R.; Jenna Reps; Uwe Aickelin

    2014-01-01

    There is great potential to be explored regarding the use of agent-based modelling and simulation as an alternative paradigm to investigate early-stage cancer interactions with the immune system. It does not suffer from some limitations of ordinary differential equation models, such as the lack of stochasticity, representation of individual behaviours rather than aggregates and individual memory. In this paper we investigate the potential contribution of agent-based modelling and simulation w...

  7. Agent-based model for rural-urban migration: A dynamic consideration

    Science.gov (United States)

    Cai, Ning; Ma, Hai-Ying; Khan, M. Junaid

    2015-10-01

    This paper develops a dynamic agent-based model for rural-urban migration, based on the previous relevant works. The model conforms to the typical dynamic linear multi-agent systems model concerned extensively in systems science, in which the communication network is formulated as a digraph. Simulations reveal that consensus of certain variable could be harmful to the overall stability and should be avoided.

  8. An Agent-Based Simulation of In-Store Customer Experiences

    OpenAIRE

    Siebers, Peer-Olaf; Aickelin, Uwe; Celia, Helen; Clegg, Chris

    2008-01-01

    Agent-based modelling and simulation offers a new and exciting way of understanding the world of work. In this paper we describe the development of an agent-based simulation model, designed to help to understand the relationship between human resource management practices and retail productivity. We report on the current development of our simulation model which includes new features concerning the evolution of customers over time. To test some of these features we have conducted a series of ...

  9. Exploring the World of Agent-Based Simulations: Simple Models, Complex Analyses

    OpenAIRE

    Sanchez, Susan M.; Lucas, Thomas W.

    2002-01-01

    Proceedings of the 2002 Winter Simulation Conference E. Yücesan, C.-H. Chen, J. L. Snowdon, and J. M. Charnes, eds. Agent-based simulations are models where multiple entities sense and stochastically respond to conditions in their local environments, mimicking complex large-scale system behavior. We provide an overview of some important issues in the modeling and analysis of agent-based systems. Examples are drawn from a range of fields: biological modeling, sociologic...

  10. Multi-Agent-Based Simulation for Analysis of Transport Policy and Infrastructure Measures

    OpenAIRE

    Holmgren, Johan; Ramstedt, Linda; Davidsson, Paul; Persson, Jan A.

    2012-01-01

    In this paper we elaborate on the usage of multi-agent-based simulation (MABS) for quantitative impact assessment of transport policy and infrastructure measures. We provide a general discussion on how to use MABS for freight transport analysis, focusing on issues related to input data management, validation and verification, calibration, output data analysis, and generalization of results. The discussion is built around an agent-based transport chain simulation tool called TAPAS (Transportat...

  11. Predictability of Shanghai Stock Market by Agent-based Mix-game Model

    CERN Document Server

    Gou, C

    2005-01-01

    This paper reports the effort of using agent-based mix-game model to predict financial time series. It introduces the prediction methodology by means of mix-game model and gives an example of its application to forecasting Shanghai Index. The results show that this prediction methodology is effective and agent-based mix-game model is a potential good model to predict time series of financial markets.

  12. Using an agent-based model to simulate children’s active travel to school

    OpenAIRE

    Yang, Yong; Diez-Roux, Ana V.

    2013-01-01

    Background Despite the multiple advantages of active travel to school, only a small percentage of US children and adolescents walk or bicycle to school. Intervention studies are in a relatively early stage and evidence of their effectiveness over long periods is limited. The purpose of this study was to illustrate the utility of agent-based models in exploring how various policies may influence children’s active travel to school. Methods An agent-based model was developed to simulate children...

  13. Vehicle-based interactive management with multi-agent approach

    Directory of Open Access Journals (Sweden)

    Yee Ming Chen

    2009-09-01

    Full Text Available Under the energy crisis and global warming, mass transportation becomes more important than before. The disadvantages of mass transportation, plus the high flexibility and efficiency of taxi and with the revolution of technology, electric-taxi is the better transportation choice for metropolis. On the other hand, among the many taxi service types, dial-a-ride (DAR service system is the better way for passenger and taxi. However the electricity replenishing of electric-taxi is the biggest shortage and constraint for DAR operation system. In order to more effectively manage the electric-taxi DAR operation system and the lots of disadvantages of physical system and observe the behaviors and interactions of simulation system, multi-agent simulation technique is the most suitable simulation technique. Finally, we use virtual data as the input of simulation system and analyze the simulation result. We successfully obtain two performance measures: average waiting time and service rate. Result shows the average waiting time is only 3.93 seconds and the service rate (total transport passenger number / total passenger number is 37.073%. So these two performance measures can support us to make management decisions. The multiagent oriented model put forward in this article is the subject of an application intended in the long term to supervise the user information system of an urban transport network.

  14. A sequence-based dynamic ensemble learning system for protein ligand-binding site prediction

    KAUST Repository

    Chen, Peng

    2015-12-03

    Background: Proteins have the fundamental ability to selectively bind to other molecules and perform specific functions through such interactions, such as protein-ligand binding. Accurate prediction of protein residues that physically bind to ligands is important for drug design and protein docking studies. Most of the successful protein-ligand binding predictions were based on known structures. However, structural information is not largely available in practice due to the huge gap between the number of known protein sequences and that of experimentally solved structures

  15. A standard protocol for describing individual-based and agent-based models

    Science.gov (United States)

    Grimm, Volker; Berger, Uta; Bastiansen, Finn; Eliassen, Sigrunn; Ginot, Vincent; Giske, Jarl; Goss-Custard, John; Grand, Tamara; Heinz, Simone K.; Huse, Geir; Huth, Andreas; Jepsen, Jane U.; Jorgensen, Christian; Mooij, Wolf M.; Muller, Birgit; Pe'er, Guy; Piou, Cyril; Railsback, Steven F.; Robbins, Andrew M.; Robbins, Martha M.; Rossmanith, Eva; Ruger, Nadja; Strand, Espen; Souissi, Sami; Stillman, Richard A.; Vabo, Rune; Visser, Ute; DeAngelis, Donald L.

    2006-01-01

    Simulation models that describe autonomous individual organisms (individual based models, IBM) or agents (agent-based models, ABM) have become a widely used tool, not only in ecology, but also in many other disciplines dealing with complex systems made up of autonomous entities. However, there is no standard protocol for describing such simulation models, which can make them difficult to understand and to duplicate. This paper presents a proposed standard protocol, ODD, for describing IBMs and ABMs, developed and tested by 28 modellers who cover a wide range of fields within ecology. This protocol consists of three blocks (Overview, Design concepts, and Details), which are subdivided into seven elements: Purpose, State variables and scales, Process overview and scheduling, Design concepts, Initialization, Input, and Submodels. We explain which aspects of a model should be described in each element, and we present an example to illustrate the protocol in use. In addition, 19 examples are available in an Online Appendix. We consider ODD as a first step for establishing a more detailed common format of the description of IBMs and ABMs. Once initiated, the protocol will hopefully evolve as it becomes used by a sufficiently large proportion of modellers.

  16. A Two-Stage Multi-Agent Based Assessment Approach to Enhance Students' Learning Motivation through Negotiated Skills Assessment

    Science.gov (United States)

    Chadli, Abdelhafid; Bendella, Fatima; Tranvouez, Erwan

    2015-01-01

    In this paper we present an Agent-based evaluation approach in a context of Multi-agent simulation learning systems. Our evaluation model is based on a two stage assessment approach: (1) a Distributed skill evaluation combining agents and fuzzy sets theory; and (2) a Negotiation based evaluation of students' performance during a training…

  17. Agent-Based Data Mining Framework for the High-Dimensional Environment

    Institute of Scientific and Technical Information of China (English)

    LI Kan; LIU Yu-shu

    2005-01-01

    An agent-based data mining framework for the high-dimensional environment is built instead of the style of classical structural programming or the object-oriented programming. The framework supports the whole process of data mining of the high-dimensional environment. Belief-desire-joint intention agents are designed to fit the characteristic of the high-dimensional environment. At the same time, the syntax, semantics and reasoning rules of the agents are given. In the data mining system of the high-dimensional environment,agents need exchange messages. The cooperation behavior mechanism is adopted to complete the communication through the three-level pattern among agents that have their own fixed roles.

  18. Flocking in Multi-Agent Systems with Multiple Virtual Leaders Based Only on Position Measurements

    Institute of Scientific and Technical Information of China (English)

    苏厚胜

    2012-01-01

    Most existing flocking algorithms assume one single virtual leader and rely on information on both relative positions and relative velocities among neighboring agents.In this paper,the problem of controlling a flock of mobile autonomous agents to follow multiple virtual leaders is investigated by using only position information in the sense that agents with the same virtual leader asymptotically attain the same velocity and track the corresponding virtual leader based on only position measurements.A flocking algorithm is proposed under which every agent asymptotically attains its desired velocity,collision between agents can be avoided,and the final tight formation minimizes all agents' global potentials.A simulation example is presented to verify and illustrate the theoretical results.

  19. Study on the E-commerce platform based on the agent

    Science.gov (United States)

    Fu, Ruixue; Qin, Lishuan; Gao, Yinmin

    2011-10-01

    To solve problem of dynamic integration in e-commerce, the Multi-Agent architecture of electronic commerce platform system based on Agent and Ontology has been introduced, which includes three major types of agent, Ontology and rule collection. In this architecture, service agent and rule are used to realize the business process reengineering, the reuse of software component, and agility of the electronic commerce platform. To illustrate the architecture, a simulation work has been done and the results imply that the architecture provides a very efficient method to design and implement the flexible, distributed, open and intelligent electronic commerce platform system to solve problem of dynamic integration in ecommerce. The objective of this paper is to illustrate the architecture of electronic commerce platform system, and the approach how Agent and Ontology support the electronic commerce platform system.

  20. Knowledge-based reasoning to annotate noncoding RNA using multi-agent system.

    Science.gov (United States)

    Arruda, Wosley C; Souza, Daniel S; Ralha, Célia G; Walter, Maria Emilia M T; Raiol, Tainá; Brigido, Marcelo M; Stadler, Peter F

    2015-12-01

    Noncoding RNAs (ncRNAs) have been focus of intense research over the last few years. Since characteristics and signals of ncRNAs are not entirely known, researchers use different computational tools together with their biological knowledge to predict putative ncRNAs. In this context, this work presents ncRNA-Agents, a multi-agent system to annotate ncRNAs based on the output of different tools, using inference rules to simulate biologists' reasoning. Experiments with data from the fungus Saccharomyces cerevisiae allowed to measure the performance of ncRNA-Agents, with better sensibility, when compared to Infernal, a widely used tool for annotating ncRNA. Besides, data of the Schizosaccharomyces pombe and Paracoccidioides brasiliensis fungi identified novel putative ncRNAs, which demonstrated the usefulness of our approach. NcRNA-Agents can be be found at: http://www.biomol.unb.br/ncrna-agents. PMID:26223200