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Sample records for billion years older

  1. Origins fourteen billion years of cosmic evolution

    CERN Document Server

    Tyson, Neil deGrasse

    2004-01-01

    Origins explores cosmic science's stunning new insights into the formation and evolution of our universe--of the cosmos, of galaxies and galaxy clusters, of stars within galaxies, of planets that orbit those stars, and of different forms of life that take us back to the first three seconds and forward through three billion years of life on Earth to today's search for life on other planets. Drawing on the current cross-pollination of geology, biology and astrophysics, Origins explains the thrilling daily breakthroughs in our knowledge of the universe from dark energy to life on Mars to the mysteries of space and time. Distilling complex science in clear and lively prose, co-authors Neil deGrasse Tyson and Donald Goldsmith conduct a galvanising tour of the cosmos revealing what the universe has been up to while turning part of itself into us.

  2. Conservation of protein structure over four billion years.

    Science.gov (United States)

    Ingles-Prieto, Alvaro; Ibarra-Molero, Beatriz; Delgado-Delgado, Asuncion; Perez-Jimenez, Raul; Fernandez, Julio M; Gaucher, Eric A; Sanchez-Ruiz, Jose M; Gavira, Jose A

    2013-09-01

    Little is known about the evolution of protein structures and the degree of protein structure conservation over planetary time scales. Here, we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating up to approximately four billion years ago. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold, whereas only small structural changes have occurred over four billion years. This remarkable degree of structure conservation since a time near the last common ancestor of life supports a punctuated-equilibrium model of structure evolution in which the generation of new folds occurs over comparatively short periods and is followed by long periods of structural stasis. PMID:23932589

  3. Conservation of protein structure over four billion years

    OpenAIRE

    Ingles-Prieto, Alvaro; Ibarra-Molero, Beatriz; Delgado-Delgado, Asuncion; Perez-Jimenez, Raul; Fernandez, Julio M.; Gaucher, Eric A.; Sanchez-Ruiz, Jose M.; Gavira, Jose A.

    2013-01-01

    Little is known with certainty about the evolution of protein structures in general and the degree of protein structure conservation over planetary time scales in particular. Here we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating back up to ~4 billion years before present. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold while only small structural cha...

  4. Orbital forcing of climate 1.4 billion years ago

    DEFF Research Database (Denmark)

    Zhang, Shuichang; Wang, Xiaomei; Hammarlund, Emma U.;

    2015-01-01

    Fluctuating climate is a hallmark of Earth. As one transcends deep into Earth time, however, both the evidence for and the causes of climate change become difficult to establish. We report geochemical and sedimentological evidence for repeated, short-term climate fluctuations from the exceptionally...... well-preserved ∼1.4-billion-year-old Xiamaling Formation of the North China Craton. We observe two patterns of climate fluctuations: On long time scales, over what amounts to tens of millions of years, sediments of the Xiamaling Formation record changes in geochemistry consistent with long-term changes...... reflect what appear to be orbitally forced changes in wind patterns and ocean circulation as they influenced rates of organic carbon flux, trace metal accumulation, and the source of detrital particles to the sediment....

  5. Fiscal Deficit Will Be Cut Down RMB19.8 Billion This Year

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ When delivering the government work report on March5, Premier Wen Jiabao said,"China will carry out the stable fiscal policy this year and cut down the fiscal deficit accordingly, plan to arrange a central fiscal deficit of RMB300 billion,which is RMB19.8 billion less than last year."

  6. Fiscal Deficit Will Be Cut Down RMB19.8 Billion This Year

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      When delivering the government work report on March5, Premier Wen Jiabao said,"China will carry out the stable fiscal policy this year and cut down the fiscal deficit accordingly, plan to arrange a central fiscal deficit of RMB300 billion,which is RMB19.8 billion less than last year."……

  7. Spatial variability in oceanic redox structure 1.8 billion years ago

    DEFF Research Database (Denmark)

    Poulton, Simon W.; Fralick, Philip W.; Canfield, Donald Eugene

    2010-01-01

    The evolution of ocean chemistry during the Proterozoic eon (2.5-0.542 billion years ago) is thought to have played a central role in both the timing and rate of eukaryote evolution(1,2). The timing of the deposition of iron formations implies that, early in the Earth's history, oceans were predo...

  8. XNMG’s Reserves Increase over RMB 230 Billion in 4 Years

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>The 100 million tons of proven iron ore in south Xinjiang marks the successful conclusion of mineral exploration of Xinjiang Nonferrous Metals Group (XNMG) this year. It enables XNMG’s potential economic value of newlyincreased resources to exceed RMB 230 billion since implementation of the strategy of geological prospecting and resource consolidation,

  9. A spin-down clock for cool stars from observations of a 2.5-billion-year-old cluster

    CERN Document Server

    Meibom, Soren; Platais, Imants; Gilliland, Ronald L; Latham, David W; Mathieu, Robert D

    2015-01-01

    The ages of the most common stars - low-mass (cool) stars like the Sun, and smaller - are difficult to derive because traditional dating methods use stellar properties that either change little as the stars age or are hard to measure. The rotation rates of all cool stars decrease substantially with time as the stars steadily lose their angular momenta. If properly calibrated, rotation therefore can act as a reliable determinant of their ages based on the method of gyrochronology. To calibrate gyrochronology, the relationship between rotation period and age must be determined for cool stars of different masses, which is best accomplished with rotation period measurements for stars in clusters with well-known ages. Hitherto, such measurements have been possible only in clusters with ages of less than about one billion years, and gyrochronology ages for older stars have been inferred from model predictions. Here we report rotation period measurements for 30 cool stars in the 2.5-billion-year-old cluster NGC 6819...

  10. A Sawtooth-like Timeline for the First Billion Year of Lunar Bombardment

    OpenAIRE

    Morbidelli, Alessandro; Marchi, Simone; Bottke, William F.; Kring, David A.

    2012-01-01

    We revisit the early evolution of the Moon's bombardment. Our work combines modeling (based on plausible projectile sources and their dynamical decay rates) with constraints from the lunar crater record, radiometric ages of the youngest lunar basins, and the abundance of highly siderophile elements in the lunar crust and mantle. We deduce that the evolution of the impact flux did not decline exponentially over the first billion years of lunar history, but also there was no prominent and "narr...

  11. The First Billion Years: The Growth of Galaxies in the Reionization Epoch

    Science.gov (United States)

    Illingworth, Garth

    2015-08-01

    Detection and measurement of the earliest galaxies in the first billion years only became possible after the Hubble Space Telescope was updated in 2009 with the infrared WFC3/IR camera during Shuttle servicing mission SM4. The first billion years is a fascinating epoch, not just because of the earliest galaxies known from about 450 Myr after the Big Bang, but also because it encompasses the reionization epoch that peaked around z~9, as Planck has recently shown, and ended around redshift z~6 at 900 Myr. Before 2009 just a handful of galaxies were known in the reionization epoch at z>6. But within the last 5 years, with the first HUDF09 survey, the HUDF12, CANDELS and numerous other surveys on the GOODS and CANDELS fields, as well as detections from the cluster lensing programs like CLASH and the Frontier Fields, the number of galaxies at redshifts 7-10 has exploded, with some 700 galaxies being found and characterized. The first billion years was a period of extraordinary growth in the galaxy population with rapid growth in the star formation rate density and global mass density in galaxies. Spitzer observations in the infrared of these Hubble fields are establishing masses as well as giving insights into the nature and timescales of star formation from the very powerful emission lines being revealed by the Spitzer IRAC data. I will discuss what we understand about the growth of galaxies in this epoch from the insights gained from remarkable deep fields like the XDF, as well as the wide-area GOODS/CANDELS fields, the detection of unexpectedly luminous galaxies at redshifts 8-10, the impact of early galaxies on reionization, confirmation of a number of galaxies at z~7-8 from ground-based spectroscopic measurements, and the indications of a change in the growth of the star formation rate around 500 Myr. The first billion years was a time of dramatic growth and change in the early galaxy population.

  12. Electron microscopy reveals unique microfossil preservation in 1 billion-year-old lakes

    International Nuclear Information System (INIS)

    Electron microscopy was applied to the study of 1 billion-year-old microfossils from northwest Scotland in order to investigate their 3D morphology and mode of fossilization. 3D-FIB-SEM revealed high quality preservation of organic cell walls with only minor amounts of post-mortem decomposition, followed by variable degrees of morphological alteration (folding and compression of cell walls) during sediment compaction. EFTEM mapping plus SAED revealed a diverse fossilizing mineral assemblage including K-rich clay, Fe-Mg-rich clay and calcium phosphate, with each mineral occupying specific microenvironments in proximity to carbonaceous microfossil cell walls

  13. Decimetre-scale multicellular eukaryotes from the 1.56-billion-year-old Gaoyuzhuang Formation in North China.

    Science.gov (United States)

    Zhu, Shixing; Zhu, Maoyan; Knoll, Andrew H; Yin, Zongjun; Zhao, Fangchen; Sun, Shufen; Qu, Yuangao; Shi, Min; Liu, Huan

    2016-01-01

    Fossils of macroscopic eukaryotes are rarely older than the Ediacaran Period (635-541 million years (Myr)), and their interpretation remains controversial. Here, we report the discovery of macroscopic fossils from the 1,560-Myr-old Gaoyuzhuang Formation, Yanshan area, North China, that exhibit both large size and regular morphology. Preserved as carbonaceous compressions, the Gaoyuzhuang fossils have statistically regular linear to lanceolate shapes up to 30 cm long and nearly 8 cm wide, suggesting that the Gaoyuzhuang fossils record benthic multicellular eukaryotes of unprecedentedly large size. Syngenetic fragments showing closely packed ∼10 μm cells arranged in a thick sheet further reinforce the interpretation. Comparisons with living thalloid organisms suggest that these organisms were photosynthetic, although their phylogenetic placement within the Eukarya remains uncertain. The new fossils provide the strongest evidence yet that multicellular eukaryotes with decimetric dimensions and a regular developmental program populated the marine biosphere at least a billion years before the Cambrian Explosion. PMID:27186667

  14. States' Spending on Colleges Rises 19 Pct. in 2 Years, Nears $31-Billion for'85-86.

    Science.gov (United States)

    Evangelauf, Jean

    1985-01-01

    The U.S. states' expenditures to nearly $31 billion in tax money mark a continuing recovery in support for higher education. Shaping this year's appropriations levels were concerns about tuition and efforts to promote economic development. (MLW)

  15. CPR - adult and child 9 years and older

    Science.gov (United States)

    Cardiopulmonary resuscitation - adult; Rescue breathing and chest compressions - adult; Resuscitation - cardiopulmonary - adult; Cardiopulmonary resuscitation - child 9 years and older; Rescue breathing ...

  16. Cooling and exhumation of continents at billion-year time scales

    Science.gov (United States)

    Blackburn, T.; Bowring, S. A.; Perron, T.; Mahan, K. H.; Dudas, F. O.

    2011-12-01

    The oldest rocks on Earth are preserved within the continental lithosphere, where assembled fragments of ancient orogenic belts have survived erosion and destruction by plate tectonic and surface processes for billions of years. Though the rate of orogenic exhumation and erosion has been measured for segments of an orogenic history, it remains unclear how these exhumation rates have changed over the lifetime of any terrane. Because the exhumation of the lithospheric surface has a direct effect on the rate of heat loss within the lithosphere, a continuous record of lithosphere exhumation can be reconstructed through the use of thermochronology. Thermochronologic studies have typically employed systems sensitive to cooling at temperatures recycling of these shallow rocks results in a poor preservation potential of any long-term record. Here, an ancient and long-term record of lithosphere exhumation is constructed using U-Pb thermochronology, a geochronologic system sensitive to cooling at temperatures found at 20-50 km depth (400-650 °C). Lower crustal xenoliths provide material that resided at these depths for billions of years or more, recording a thermal history that is buried deep enough to remain insensitive to upper crustal deformation and instead is dominated by the vertical motions of the continents. We show how this temperature-sensitive system can produce a long-term integrated measure of continental exhumation and erosion. Preserved beneath Phanerozoic sedimentary rocks within Montana, USA, the Great Falls Tectonic Zone formed when two Archean cratons, the Wyoming Province and Medicine Hat Block collided at ~1.8 Ga. Rutile U-Pb data from multiple xenoliths, each exhumed from a different depth within the crustal column reveal a range of dates that varies as a function of xenolith residence depth. The shallowest mid- to lower crustal xenoliths (~25 km) cooled first, yielding the youngest dates and yet cooled at rates between 0.1-0.25 °C/Ma over 500 My or

  17. The evolution in the stellar mass of Brightest Cluster Galaxies over the past 10 billion years

    Science.gov (United States)

    Bellstedt, Sabine; Lidman, Chris; Muzzin, Adam; Franx, Marijn; Guatelli, Susanna; Hill, Allison R.; Hoekstra, Henk; Kurinsky, Noah; Labbe, Ivo; Marchesini, Danilo; Marsan, Z. Cemile; Safavi-Naeini, Mitra; Sifón, Cristóbal; Stefanon, Mauro; van de Sande, Jesse; van Dokkum, Pieter; Weigel, Catherine

    2016-05-01

    Using a sample of 98 galaxy clusters recently imaged in the near infra-red with the ESO NTT, WIYN and WHT telescopes, supplemented with 33 clusters from the ESO archive, we measure how the stellar mass of the most massive galaxies in the universe, namely Brightest Cluster Galaxies (BCG), increases with time. Most of the BCGs in this new sample lie in the redshift range 0.2 evidence indicates that the stellar mass growth rate of BCGs may be slowing in the past 3.5 billion years. Further work in collecting larger samples, and in better comparing observations with theory using mock images is required if a more detailed comparison between the models and the data is to be made.

  18. Dust production 0.7-1.5 billion years after the Big Bang

    CERN Document Server

    Michałowski, Michał J

    2015-01-01

    Cosmic dust is an important component of the Universe, and its origin, especially at high redshifts, is still unknown. I present a simple but powerful method of assessing whether dust observed in a given galaxy could in principle have been formed by asymptotic giant branch (AGB) stars or supernovae (SNe). Using this method I show that for most of the galaxies with detected dust emission between z=4 and z=7.5 (1.5-0.7 billion years after the Big Bang) AGB stars are not numerous and efficient enough to be responsible for the measured dust masses. Supernovae could account for most of the dust, but only if all of them had efficiencies close to the maximal theoretically allowed value. This suggests that a different mechanism is responsible for dust production at high redshifts, and the most likely possibility is the grain growth in the interstellar medium.

  19. Exploring the Impact of Galaxy Interactions over Seven Billion Years with CAS

    CERN Document Server

    Miller, Sarah H; Conselice, C; Penner, K; Bell, E; Zheng, X; Papovich, C; Skelton, R; Somerville, R; Rix, H; Barazza, F; Barden, M; Borch, A; Beckwith, S; Caldwell, J; Haeussler, B; Heymans, C; Jahnke, K; McIntosh, D; Meisenheimer, K; Peng, C; Robaina, A; Sanchez, S; Wisotzki, L; Wolf, C

    2008-01-01

    We explore galaxy assembly over the last seven billion years by characterizing "normal" galaxies along the Hubble sequence, against strongly disturbed merging/interacting galaxies with the widely used CAS system of concentration (C), asymmetry (A), and 'clumpiness' (S) parameters, as well as visual classification. We analyze Hubble Space Telescope (HST) ACS images of ~4000 intermediate and high mass (> 10^9 solar masses) galaxies from the GEMS survey, one of the largest HST surveys conducted to date in two filters. We explore the effectiveness of the CAS criteria [A>S and A>~0.35] in separating normal and strongly disturbed galaxies at different redshifts, and quantify the recovery and contamination rate. We also compare the average star formation rate and the cosmic star formation rate density as a function of redshift between normal and interacting systems identified by CAS.

  20. The habitability of the Universe through 13 billion years of cosmic time

    CERN Document Server

    Dayal, Pratika; Cockell, Charles

    2016-01-01

    The field of astrobiology has made tremendous progress in modelling galactic-scale habitable zones which offer a stable environment for life to form and evolve in complexity. Recently, this idea has been extended to cosmological scales by studies modelling the habitability of the local Universe in its entirety (e.g. Dayal et al. 2015; Li & Zhang 2015). However, all of these studies have solely focused on estimating the potentially detrimental effects of either Type II supernovae (SNII) or Gamma Ray Bursts (GRBs), ignoring the contributions from Type Ia supernovae (SNIa) and active galactic nuclei (AGN). In this study we follow two different approaches, based on (i) the amplitude of deleterious radiation and (ii) the total planet-hosting volume irradiated by deleterious radiation. We simultaneously track the contributions from the key astrophysical sources (SNII, SNIa, AGN and GRBs) for the entire Universe, for both scenarios, to determine its habitability through 13.8 billion years of cosmic time. We find...

  1. Searching for Organics Preserved in 4.5 Billion Year Old Salt

    Science.gov (United States)

    Zolensky, Michael E.; Fries, M.; Steele, A.; Bodnar, R.

    2012-01-01

    Our understanding of early solar system fluids took a dramatic turn a decade ago with the discovery of fluid inclusion-bearing halite (NaCl) crystals in the matrix of two freshly fallen brecciated H chondrite falls, Monahans and Zag. Both meteorites are regolith breccias, and contain xenolithic halite (and minor admixed sylvite -- KCl, crystals in their regolith lithologies. The halites are purple to dark blue, due to the presence of color centers (electrons in anion vacancies) which slowly accumulated as 40K (in sylvite) decayed over billions of years. The halites were dated by K-Ar, Rb-Sr and I-Xe systematics to be 4.5 billion years old. The "blue" halites were a fantastic discovery for the following reasons: (1) Halite+sylvite can be dated (K is in sylvite and will substitute for Na in halite, Rb substitutes in halite for Na, and I substitutes for Cl). (2) The blue color is lost if the halite dissolves on Earth and reprecipitates (because the newly-formed halite has no color centers), so the color serves as a "freshness" or pristinity indicator. (3) Halite frequently contains aqueous fluid inclusions. (4) Halite contains no structural oxygen, carbon or hydrogen, making them ideal materials to measure these isotopic systems in any fluid inclusions. (5) It is possible to directly measure fluid inclusion formation temperatures, and thus directly measure the temperature of the mineralizing aqueous fluid. In addition to these two ordinary chondrites halite grains have been reliably reported in several ureilites, an additional ordinary chondrite (Jilin), and in the carbonaceous chondrite (Murchison), although these reports were unfortunately not taken seriously. We have lately found additional fluid inclusions in carbonates in several additional carbonaceous chondrites. Meteoritic aqueous fluid inclusions are apparently relatively widespread in meteorites, though very small and thus difficult to analyze.

  2. An anoxic, Fe(II)-rich, U-poor ocean 3.46 billion years ago

    Science.gov (United States)

    Li, Weiqiang; Czaja, Andrew D.; Van Kranendonk, Martin J.; Beard, Brian L.; Roden, Eric E.; Johnson, Clark M.

    2013-11-01

    The oxidation state of the atmosphere and oceans on the early Earth remains controversial. Although it is accepted by many workers that the Archean atmosphere and ocean were anoxic, hematite in the 3.46 billion-year-old (Ga) Marble Bar Chert (MBC) from Pilbara Craton, NW Australia has figured prominently in arguments that the Paleoarchean atmosphere and ocean was fully oxygenated. In this study, we report the Fe isotope compositions and U concentrations of the MBC, and show that the samples have extreme heavy Fe isotope enrichment, where δ56Fe values range between +1.5‰ and +2.6‰, the highest δ56Fe values for bulk samples yet reported. The high δ56Fe values of the MBC require very low levels of oxidation and, in addition, point to a Paleoarchean ocean that had high aqueous Fe(II) contents. A dispersion/reaction model indicates that O2 contents in the photic zone of the ocean were less than 10-3 μM, which suggests that the ocean was essentially anoxic. An independent test of anoxic conditions is provided by U-Th-Pb isotope systematics, which show that U contents in the Paleoarchean ocean were likely below 0.02 ppb, two orders-of-magnitude lower than the modern ocean. Collectively, the Fe and U data indicate a reduced, Fe(II)-rich, U-poor environment in the Archean oceans at 3.46 billion years ago. Given the evidence for photosynthetic communities provided by broadly coeval stromatolites, these results suggests that an important photosynthetic pathway in the Paleoarchean oceans may have been anoxygenic photosynthetic Fe(II) oxidation.

  3. Prodigious degassing of a billion years of accumulated radiogenic helium at Yellowstone

    Science.gov (United States)

    Lowenstern, Jacob B.; Evans, William C.; Bergfeld, D.; Hunt, Andrew G.

    2014-01-01

    Helium is used as a critical tracer throughout the Earth sciences, where its relatively simple isotopic systematics is used to trace degassing from the mantle, to date groundwater and to time the rise of continents1. The hydrothermal system at Yellowstone National Park is famous for its high helium-3/helium-4 isotope ratio, commonly cited as evidence for a deep mantle source for the Yellowstone hotspot2. However, much of the helium emitted from this region is actually radiogenic helium-4 produced within the crust by α-decay of uranium and thorium. Here we show, by combining gas emission rates with chemistry and isotopic analyses, that crustal helium-4 emission rates from Yellowstone exceed (by orders of magnitude) any conceivable rate of generation within the crust. It seems that helium has accumulated for (at least) many hundreds of millions of years in Archaean (more than 2.5 billion years old) cratonic rocks beneath Yellowstone, only to be liberated over the past two million years by intense crustal metamorphism induced by the Yellowstone hotspot. Our results demonstrate the extremes in variability of crustal helium efflux on geologic timescales and imply crustal-scale open-system behaviour of helium in tectonically and magmatically active regions.

  4. Evidence for Mature Bulges and an Inside-out Quenching Phase 3 Billion Years After the Big Bang

    CERN Document Server

    Tacchella, S; Renzini, A; Schreiber, N M Förster; Lang, P; Wuyts, S; Cresci, G; Dekel, A; Genzel, R; Lilly, S J; Mancini, C; Newman, S; Onodera, M; Shapley, A; Tacconi, L; Woo, J; Zamorani, G

    2015-01-01

    Most present-day galaxies with stellar masses $\\geq10^{11}$ solar masses show no ongoing star formation and are dense spheroids. Ten billion years ago, similarly massive galaxies were typically forming stars at rates of hundreds solar masses per year. It is debated how star formation ceased, on which timescales, and how this "quenching" relates to the emergence of dense spheroids. We measured stellar mass and star-formation rate surface density distributions in star-forming galaxies at redshift 2.2 with $\\sim1$ kiloparsec resolution. We find that, in the most massive galaxies, star formation is quenched from the inside out, on timescales less than 1 billion years in the inner regions, up to a few billion years in the outer disks. These galaxies sustain high star-formation activity at large radii, while hosting fully grown and already quenched bulges in their cores.

  5. Galaxy evolution. Evidence for mature bulges and an inside-out quenching phase 3 billion years after the Big Bang.

    Science.gov (United States)

    Tacchella, S; Carollo, C M; Renzini, A; Förster Schreiber, N M; Lang, P; Wuyts, S; Cresci, G; Dekel, A; Genzel, R; Lilly, S J; Mancini, C; Newman, S; Onodera, M; Shapley, A; Tacconi, L; Woo, J; Zamorani, G

    2015-04-17

    Most present-day galaxies with stellar masses ≥10(11) solar masses show no ongoing star formation and are dense spheroids. Ten billion years ago, similarly massive galaxies were typically forming stars at rates of hundreds solar masses per year. It is debated how star formation ceased, on which time scales, and how this "quenching" relates to the emergence of dense spheroids. We measured stellar mass and star-formation rate surface density distributions in star-forming galaxies at redshift 2.2 with ~1-kiloparsec resolution. We find that, in the most massive galaxies, star formation is quenched from the inside out, on time scales less than 1 billion years in the inner regions, up to a few billion years in the outer disks. These galaxies sustain high star-formation activity at large radii, while hosting fully grown and already quenched bulges in their cores. PMID:25883353

  6. Half a billion years of good weather: Gaia or good luck?

    Science.gov (United States)

    Waltham, Dave

    2007-06-01

    For the past 550 million years, Earth has had a relatively stable climate, with average global temperatures generally fluctuating by less than 10°C from the present value of around 15°C. In the preceding 4 billion years, temperature fluctuations were almost an order of magnitude greater. One explanation for climate stability is that the biosphere evolves to maintain optimum conditions for life (the Gaia hypothesis). But this stability could also result from luck and, without such good fortune, conditions on Earth would have been unsuitable for the evolution of complex life: anthropic selection, in other words. One element of such good luck concerns the climatic impact of the Moon; the properties of the Earth-Moon system only just allow a stable rotation axis for the Earth (considered a prerequisite for climate stability and the evolution of complex life). Axial stability also requires Jupiter and Saturn to be widely spaced, offering a test of the rarity or otherwise of the solar system arrangement among exoplanet systems. Gravitational microlensing surveys should allow this to be tested within a decade.

  7. A large neutral fraction of cosmic hydrogen a billion years after the Big Bang.

    Science.gov (United States)

    Wyithe, J Stuart B; Loeb, Abraham

    2004-02-26

    The fraction of ionized hydrogen left over from the Big Bang provides evidence for the time of formation of the first stars and quasar black holes in the early Universe; such objects provide the high-energy photons necessary to ionize hydrogen. Spectra of the two most distant known quasars show nearly complete absorption of photons with wavelengths shorter than the Lyman alpha transition of neutral hydrogen, indicating that hydrogen in the intergalactic medium (IGM) had not been completely ionized at a redshift of z approximately 6.3, about one billion years after the Big Bang. Here we show that the IGM surrounding these quasars had a neutral hydrogen fraction of tens of per cent before the quasar activity started, much higher than the previous lower limits of approximately 0.1 per cent. Our results, when combined with the recent inference of a large cumulative optical depth to electron scattering after cosmological recombination therefore suggest the presence of a second peak in the mean ionization history of the Universe. PMID:14985754

  8. The evolution in the stellar mass of Brightest Cluster Galaxies over the past 10 billion years

    CERN Document Server

    Bellstedt, Sabine; Muzzin, Adam; Franx, Marijn; Guatelli, Susanna; Hill, Allison R; Hoekstra, Henk; Kurinsky, Noah; Labbe, Ivo; Marchesini, Danilo; Marsan, Z Cemile; Safavi-Naeini, Mitra; Sifon, Cristobal; Stefanon, Mauro; van de Sande, Jesse; van Dokkum, Pieter; Weigel, Catherine

    2016-01-01

    Using a sample of 98 galaxy clusters recently imaged in the near infra-red with the ESO NTT, WIYN and WHT telescopes, supplemented with 33 clusters from the ESO archive, we measure how the stellar mass of the most massive galaxies in the universe, namely Brightest Cluster Galaxies (BCG), increases with time. Most of the BCGs in this new sample lie in the redshift range $0.2billion years ago to the present epoch is broadly consistent with recent semi-analytic and semi-empirical models. As in other recent studies, tentative evidence indicates that the stellar mass growth rate of BCGs may be slowing in the past 3.5 billi...

  9. Survival of pure disk galaxies over the last 8 billion years

    CERN Document Server

    Sachdeva, Sonali

    2016-01-01

    Pure disk galaxies without any bulge component, i.e., neither classical nor pseudo, seem to have escaped the affects of merger activity inherent to hierarchical galaxy formation models as well as strong internal secular evolution. We discover that a significant fraction (15 - 18 %) of disk galaxies in the Hubble Deep Field (0.4 < z < 1.0) as well as in the local Universe (0.02 < z < 0.05) are such pure disk systems (hereafter, PDS). The spatial distribution of light in these PDS is well described by a single exponential function from the outskirts to the centre and appears to have remained intact over the last 8 billion years keeping the mean central surface brightness and scale-length nearly constant. These two disk parameters of PDS are brighter and shorter, respectively, than of those disks which are part of disk galaxies with bulges. Since the fraction of PDS as well as their profile defining parameters do not change, it indicates that these galaxies have not witnessed either major mergers or ...

  10. The First Billion Years project: Gamma-ray bursts at z>5

    CERN Document Server

    Elliott, J; Greiner, J; Vecchia, C Dalla

    2014-01-01

    Long gamma-ray bursts (LGRBs) have been suggested as close tracers of the underlying star formation rate in the Universe. They could potentially be used to probe the cosmic star formation history (CSFH) with high accuracy due to their high luminosities. We utilise two cosmological simulations from the First Billion Years project to investigate the systematic biases between the CSFH and the LGRB rate at z>5. We populate LGRBs using a Monte-Carlo technique and a sub-selection based on environmental metallicity, progenitor stellar mass and age. Using a physically motivated LGRB progenitor model, we demonstrate that the LGRB rate should trace the CSFH to high redshifts z>5. The measured LGRB rate suggests that LGRBs have opening angles of 0.1 degrees, although the degeneracy with the progenitor model cannot rule out an underlying bias. We demonstrate that proxies that relate the LGRB rate with global LGRB host properties do not reflect the underlying LGRB environment, and are in fact a result of the host galaxy's...

  11. A Massive Galaxy in Its Core Formation Phase Three Billion Years After the Big Bang

    Science.gov (United States)

    Nelson, Erica; van Dokkum, Pieter; Franx, Marijn; Brammer, Gabriel; Momcheva, Ivelina; Schreiber, Natascha M. Forster; da Cunha, Elisabete; Tacconi, Linda; Bezanson, Rachel; Kirkpatrick, Allison; Leja, Joel; Rix, Hans-Walter; Skelton, Rosalind; van der Wel, Arjen; Whitaker, Katherine; Wuyts, Stijn

    2014-01-01

    Most massive galaxies are thought to have formed their dense stellar cores at early cosmic epochs. However, cores in their formation phase have not yet been observed. Previous studies have found galaxies with high gas velocity dispersions or small apparent sizes but so far no objects have been identified with both the stellar structure and the gas dynamics of a forming core. Here we present a candidate core in formation 11 billion years ago, at z = 2.3. GOODS-N-774 has a stellar mass of 1.0 × 10 (exp 11) solar mass, a half-light radius of 1.0 kpc, and a star formation rate of 90 (sup +45 / sub -20) solar mass/yr. The star forming gas has a velocity dispersion 317 plus or minus 30 km/s, amongst the highest ever measured. It is similar to the stellar velocity dispersions of the putative descendants of GOODS-N-774, compact quiescent galaxies at z is approximately equal to 2 (exp 8-11) and giant elliptical galaxies in the nearby Universe. Galaxies such as GOODS-N-774 appear to be rare; however, from the star formation rate and size of the galaxy we infer that many star forming cores may be heavily obscured, and could be missed in optical and near-infrared surveys.

  12. The First Billion Years project: dark matter haloes going from contraction to expansion and back again

    CERN Document Server

    Davis, Andrew J; Vecchia, Claudio Dalla

    2013-01-01

    We study the effect of baryons on the inner dark matter profile in a large statistical sample of the first galaxies using the First Billion Years simulation between $z=16-6$. Using two simulations of the same volume and cosmological initial conditions, one with and one without baryons, we are able to directly compare haloes with their baryon-free counterparts, allowing a detailed study of the modifications to the dark matter density profile due to the presence of baryons. For each of the $\\approx 5000$ haloes in our sample, we quantify the impact of the baryons using $\\eta$, defined as the ratio of dark matter mass enclosed in 100 pc in the baryonic run to its counterpart without baryons. We find there is not one general baryonic impact on the dark matter; many haloes show an enhancement of dark matter in the halo centre compared to the baryon-free simulation, while many others show a deficit. We find that the mean value of $\\eta$ is close to unity, but there is a large dispersion, with a standard deviation o...

  13. The First Billion Years project: birthplaces of direct collapse black holes

    CERN Document Server

    Agarwal, Bhaskar; Johnson, Jarrett L; Khochfar, Sadegh; Paardekooper, Jan-Pieter

    2014-01-01

    We investigate the environment in which direct-collapse black holes may form by analysing a cosmological, hydrodynamical simulation that is part of the First Billion Years project. This simulation includes the most relevant physical processes leading to direct collapse of haloes, most importantly, molecular hydrogen depletion by dissociation of $H_2$ and $H^-$ from the evolving Lyman-Werner radiation field. We selected a sample of pristine atomic cooling haloes that have never formed stars in their past, have not been polluted with heavy elements and are cooling predominantly via atomic hydrogen lines. Amongst them we identified six haloes that could potentially harbour massive seed black holes formed via direct collapse (with masses in the range of $10^{4-6} M_{sun}$). These potential hosts of direct-collapse black holes form as satellites and are found within 15 physical kpc of proto-galaxies, with stellar masses in the range $10^{5-7} M_{sun}$ and maximal star formation rates of 0.1 Msun/yr over the past 5...

  14. Potentially biogenic carbon preserved in a 4.1 billion-year-old zircon.

    Science.gov (United States)

    Bell, Elizabeth A; Boehnke, Patrick; Harrison, T Mark; Mao, Wendy L

    2015-11-24

    Evidence of life on Earth is manifestly preserved in the rock record. However, the microfossil record only extends to ∼ 3.5 billion years (Ga), the chemofossil record arguably to ∼ 3.8 Ga, and the rock record to 4.0 Ga. Detrital zircons from Jack Hills, Western Australia range in age up to nearly 4.4 Ga. From a population of over 10,000 Jack Hills zircons, we identified one >3.8-Ga zircon that contains primary graphite inclusions. Here, we report carbon isotopic measurements on these inclusions in a concordant, 4.10 ± 0.01-Ga zircon. We interpret these inclusions as primary due to their enclosure in a crack-free host as shown by transmission X-ray microscopy and their crystal habit. Their δ(13)CPDB of -24 ± 5‰ is consistent with a biogenic origin and may be evidence that a terrestrial biosphere had emerged by 4.1 Ga, or ∼ 300 My earlier than has been previously proposed. PMID:26483481

  15. The formation of submillimetre-bright galaxies from gas infall over a billion years.

    Science.gov (United States)

    Narayanan, Desika; Turk, Matthew; Feldmann, Robert; Robitaille, Thomas; Hopkins, Philip; Thompson, Robert; Hayward, Christopher; Ball, David; Faucher-Giguère, Claude-André; Kereš, Dušan

    2015-09-24

    Submillimetre-bright galaxies at high redshift are the most luminous, heavily star-forming galaxies in the Universe and are characterized by prodigious emission in the far-infrared, with a flux of at least five millijanskys at a wavelength of 850 micrometres. They reside in haloes with masses about 10(13) times that of the Sun, have low gas fractions compared to main-sequence disks at a comparable redshift, trace complex environments and are not easily observable at optical wavelengths. Their physical origin remains unclear. Simulations have been able to form galaxies with the requisite luminosities, but have otherwise been unable to simultaneously match the stellar masses, star formation rates, gas fractions and environments. Here we report a cosmological hydrodynamic galaxy formation simulation that is able to form a submillimetre galaxy that simultaneously satisfies the broad range of observed physical constraints. We find that groups of galaxies residing in massive dark matter haloes have increasing rates of star formation that peak at collective rates of about 500-1,000 solar masses per year at redshifts of two to three, by which time the interstellar medium is sufficiently enriched with metals that the region may be observed as a submillimetre-selected system. The intense star formation rates are fuelled in part by the infall of a reservoir gas supply enabled by stellar feedback at earlier times, not through major mergers. With a lifetime of nearly a billion years, our simulations show that the submillimetre-bright phase of high-redshift galaxies is prolonged and associated with significant mass buildup in early-Universe proto-clusters, and that many submillimetre-bright galaxies are composed of numerous unresolved components (for which there is some observational evidence). PMID:26399829

  16. THE SOUTHERN FRAGMENT OF THE SIBERIAN CRATON: “LANDSCAPE” HISTORY OVER TWO BILLION YEARS

    Directory of Open Access Journals (Sweden)

    Arkady M. Stanevich

    2015-09-01

    background of sub-continental sedimentation. In the Late Paleozoic, the geologic development was marked by major transformation of the pattern of tectonic structures, that was most likely related to inside-plate extension and thinning of the continental crust. In the Mid and Late Carbon (Fig. 4A, the integrated Tungusskiy sedimentation basin was formed as a result of continuous and uniform bending. In the Early Permian (see Fig. 4Б, positive tectonic movements led to significant dewatering of the Paleozoic basins, so that they turned into a washed-out area. Overall raising of the Siberian Platform preconditioned climate changes, such as aridization and climate cooling. In the Mesozoic, landscapes were presented by a combination of flat uplands, wide river valleys with swampy plains and lakes wherein carbonous sediments were accumulated. Basic volcanism with shield eruptions and sub-volcanic rocks was typical then. In the Jurassic (see Fig. 4B, elements observed in the recent topography of the Siberian Platform were formed. In that period, major structural transformation occurred in association with the largest diastrophic cycles in the territory of the Eastern Asia, including formation of the Baikal rift and its branches.From the analyses of the available data which are briefly presented above, it is obvious that the period of two billion years in the Earth history includes numerous epochs of diastrophic processes of tremendous destructive capacity. Unconformities of formations differing in ages by millions and even hundreds of million years, as those dating back to the Pre-Cambrian, suggest quite realistic yet astounding visions. At the background of scenarios of floods, rock up-thrusts, volcanic explosions and earthquakes evidenced from the very remote past, the current geological and climatic phenomena may seem quite trivial.

  17. Breast Cancer in Women Older Than 80 Years.

    Science.gov (United States)

    Shachar, Shlomit Strulov; Hurria, Arti; Muss, Hyman B

    2016-02-01

    Breast cancer is the most common cancer in women, with an incidence that rises dramatically with age. The average age at diagnosis of breast cancer is 61 years, and the majority of woman who die of breast cancer are age 65 years and older. Major improvements in public health and medical care have resulted in dramatic increases in longevity. The oldest old (those age 80 years and older) are a rapidly expanding group and now comprise 9 million members of the US population. The treatment of individuals who are age 80 years and older is complex and involves clearly defining the goals and value of treatment while also weighing risks, such as the potential effects of treatment on functional loss and quality of life. Limited evidence-based treatment guidelines exist for the caring of this older cohort of patients with breast cancer. Data from clinical trials that enroll primarily younger patients lack the information needed to estimate the likelihood of toxicities that can be life changing in older adults. Clinicians who make treatment recommendations should place the available evidence in the context of the patient's life expectancy and geriatric assessment results that include an evaluation of a patient's functional status, comorbidities, cognition, social support, nutritional status, and psychological state. Furthermore, these decisions should be placed in the context of the patient's goals for treatment, preferences, and values. This review summarizes the current literature and focuses on the role of geriatric assessment in treatment recommendations for patients age 80 years and older with early and metastatic breast cancer. PMID:26869650

  18. Maxillofacial intervention in trauma patients aged 60 years and older

    Directory of Open Access Journals (Sweden)

    Subhashraj K

    2008-01-01

    Full Text Available The purpose of this study was to evaluate the incidence of trauma victims of age 60 years and older who required maxillofacial intervention. The study analyses the pattern of injuries and the various factors that predict the treatment plan of these patients. A retrospective study was carried out in 1820 trauma patients who reported to the Sri. Ramachandra Dental College and Hospital and required maxillofacial intervention, over a period of 5 years (October 2000 and September 2005. Of the total trauma victims, 185 patients were found to be aged 60 years more. In the majority of the patients, the injury was due to road traffic accidents (79.4%. Males (72.4% sustained more injuries than females (27.6%. Soft tissue injuries were seen in 49.1% of the patients, while 14% had mandibular fractures. People in their early 60s were injured more often than their older counterparts. The findings of this study highlight the present situation with regard to maxillofacial trauma in patients aged 60 years and older and its management in this part of the country.

  19. Shoulder dislocation in patients older than 60 years of age

    OpenAIRE

    Rapariz Jose; Martin-Martin Silvia; Pareja-Bezares Antonio; Ortega-Klein Jose

    2010-01-01

    Purpose: Recurrent anterior shoulder dislocation in elderly patients is a little studied condition. The goal of this paper is to clarify the role of associated injuries with respect to loss of function and recurrence of dislocation. Materials and Methods: We have conducted a retrospective, descriptive study on 29 patients older than 60 years at the moment they suffered their first dislocation episode. All patients were assessed clinically (Constant test) and by imaging testing (X-ray, MRI). ...

  20. Earth's air pressure 2.7 billion years ago constrained to less than half of modern levels

    Science.gov (United States)

    Som, Sanjoy M.; Buick, Roger; Hagadorn, James W.; Blake, Tim S.; Perreault, John M.; Harnmeijer, Jelte P.; Catling, David C.

    2016-06-01

    How the Earth stayed warm several billion years ago when the Sun was considerably fainter is the long-standing problem of the `faint young Sun paradox'. Because of negligible O2 and only moderate CO2 levels in the Archaean atmosphere, methane has been invoked as an auxiliary greenhouse gas. Alternatively, pressure broadening in a thicker atmosphere with a N2 partial pressure around 1.6-2.4 bar could have enhanced the greenhouse effect. But fossilized raindrop imprints indicate that air pressure 2.7 billion years ago (Gyr) was below twice modern levels and probably below 1.1 bar, precluding such pressure enhancement. This result is supported by nitrogen and argon isotope studies of fluid inclusions in 3.0-3.5 Gyr rocks. Here, we calculate absolute Archaean barometric pressure using the size distribution of gas bubbles in basaltic lava flows that solidified at sea level ~2.7 Gyr in the Pilbara Craton, Australia. Our data indicate a surprisingly low surface atmospheric pressure of Patm = 0.23 +/- 0.23 (2σ) bar, and combined with previous studies suggests ~0.5 bar as an upper limit to late Archaean Patm. The result implies that the thin atmosphere was rich in auxiliary greenhouse gases and that Patm fluctuated over geologic time to a previously unrecognized extent.

  1. Decimetre-scale multicellular eukaryotes from the 1.56-billion-year-old Gaoyuzhuang Formation in North China

    OpenAIRE

    Zhu, Shixing; Zhu, Maoyan; Knoll, Andrew H.; YIN, ZONGJUN; Zhao, Fangchen; Sun, Shufen; Qu, Yuangao; Shi, Min; Liu, Huan

    2016-01-01

    Fossils of macroscopic eukaryotes are rarely older than the Ediacaran Period (635–541 million years (Myr)), and their interpretation remains controversial. Here, we report the discovery of macroscopic fossils from the 1,560-Myr-old Gaoyuzhuang Formation, Yanshan area, North China, that exhibit both large size and regular morphology. Preserved as carbonaceous compressions, the Gaoyuzhuang fossils have statistically regular linear to lanceolate shapes up to 30 cm long and nearly 8 cm wide, sugg...

  2. The Archean Dongwanzi ophiolite complex, North China craton: 2.505-billion-year-old oceanic crust and mantle.

    Science.gov (United States)

    Kusky, T M; Li, J H; Tucker, R D

    2001-05-11

    We report a thick, laterally extensive 2505 +/- 2.2-million-year-old (uranium-lead ratio in zircon) Archean ophiolite complex in the North China craton. Basal harzburgite tectonite is overlain by cumulate ultramafic rocks, a mafic-ultramafic transition zone of interlayered gabbro and ultramafic cumulates, compositionally layered olivine-gabbro and pyroxenite, and isotropic gabbro. A sheeted dike complex is rooted in the gabbro and overlain by a mixed dike-pillow lava section, chert, and banded iron formation. The documentation of a complete Archean ophiolite implies that mechanisms of oceanic crustal accretion similar to those of today were in operation by 2.5 billion years ago at divergent plate margins and that the temperature of the early mantle was not extremely elevated, as compared to the present-day temperature. Plate tectonic processes similar to those of the present must also have emplaced the ophiolite in a convergent margin setting. PMID:11349144

  3. States' Tax Funds for Colleges Top $28-Billion, Up 16 Pct. in 2 Years.

    Science.gov (United States)

    Evangelauf, Jean

    1984-01-01

    The results of an annual national survey of state appropriations for higher education are analyzed and discussed and it is suggested that the 16 percent increase in a two-year period may mark the beginning of a recovery for tax support of higher education. (MSE)

  4. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    Directory of Open Access Journals (Sweden)

    Li Mo

    2016-01-01

    Conclusions: The finding from this study revealed that inpatients aged 80 years or older encountered more PIM use than those aged 65-79 years. Anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin are medications that often prescribed to inpatients aged 80 years or older. Doctors should carefully choose drugs for the elderly, especially the elderly aged 80 years or older.

  5. Review of Geological history of Greenland—four billion years of Earth evolution, by Niels Henriksen

    OpenAIRE

    Elvevold, Synnøve

    2010-01-01

    A translation of the Danish book Grønlands geologiske udvikling, published in 2005, Geological history of Greenland summarizes the results of more than 60 years of geological mapping and investigations in Greenland by the Geological Survey of Denmark and Greenland. This is a beautifully illustrated, large-format volume. The 270 pages provide a stunning visual presentation, with as many as 850 colour illustrations, photographs and maps accompanied by comprehensive captions. Even if the reader ...

  6. Screening mammography in women 65 years old and older

    International Nuclear Information System (INIS)

    This paper compares the results of mammographic screening in women aged 65 years and older to those of women aged 50--64 years, to define risk factors and prior use of mammography in these women, and to determine whether mammographic abnormalities are managed differently in the two age groups. Historical data, mammographic findings, and biopsy results were analyzed for all women over 50 years of age screened during 1988 (2,862 patients) at a university hospital-based outpatient center and mobile van, excluding those referred by oncologists. The following factors were determined for patients screened at the outpatient center and the mobile van, with both groups divided according to patient age (50--64 vs ≥ 65 years): presence of risk factors, previous biopsy, exogenous hormones, percentage of black patients, previous mammography, biopsy rate, cancer detection rate, positive nodes, and presence of tumors smaller than 1 cm or ductal carcinoma in-situ

  7. Plate tectonics 2.5 billion years ago - Evidence at Kolar, south India

    Science.gov (United States)

    Krogstad, E. J.; Hanson, G. N.; Balakrishnan, S.; Rajamani, V.; Mukhopadhyay, D. K.

    1989-01-01

    The Archean Kolar Schist Belt, south India, is a suture zone where two gneiss terranes and at least two amphibolite terranes with distinct histories were accreted. Amphibolites from the eastern and western sides of the schist belt have distinct incompatible element and isotopic characteristics suggesting that their volcanic protoliths were derived from different mantle sources. The amphibolite and gneiss terranes were juxtaposed by horizontal compression and shearing between 2530 and 2420 million years ago (Ma) along a zone marked by the Kolar Schist Belt. This history of accretion of discrete crustal terranes resembles those of Phanerozoic convergent margins and thus suggests that plate tectonics operated on earth by 2500 Ma.

  8. 1.8 Billion Years of Detrital Zircon Recycling Calibrates a Refractory Part of Earth’s Sedimentary Cycle

    Science.gov (United States)

    Hadlari, Thomas; Swindles, Graeme T.; Galloway, Jennifer M.; Bell, Kimberley M.; Sulphur, Kyle C.; Heaman, Larry M.; Beranek, Luke P.; Fallas, Karen M.

    2015-01-01

    Detrital zircon studies are providing new insights on the evolution of sedimentary basins but the role of sedimentary recycling remains largely undefined. In a broad region of northwestern North America, this contribution traces the pathway of detrital zircon sand grains from Proterozoic sandstones through Phanerozoic strata and argues for multi-stage sedimentary recycling over more than a billion years. As a test of our hypothesis, integrated palynology and detrital zircon provenance provides clear evidence for erosion of Carboniferous strata in the northern Cordillera as a sediment source for Upper Cretaceous strata. Our results help to calibrate Earth's sedimentary cycle by showing that recycling dominates sedimentary provenance for the refractory mineral zircon. PMID:26658165

  9. Constraint on a varying proton-electron mass ratio 1.5 billion years after the big bang.

    Science.gov (United States)

    Bagdonaite, J; Ubachs, W; Murphy, M T; Whitmore, J B

    2015-02-20

    A molecular hydrogen absorber at a lookback time of 12.4 billion years, corresponding to 10% of the age of the Universe today, is analyzed to put a constraint on a varying proton-electron mass ratio, μ. A high resolution spectrum of the J1443+2724 quasar, which was observed with the Very Large Telescope, is used to create an accurate model of 89 Lyman and Werner band transitions whose relative frequencies are sensitive to μ, yielding a limit on the relative deviation from the current laboratory value of Δμ/μ=(-9.5 ± 5.4(stat)± 5.3(syst))×10(-6). PMID:25763949

  10. 1.8 Billion Years of Detrital Zircon Recycling Calibrates a Refractory Part of Earth's Sedimentary Cycle.

    Science.gov (United States)

    Hadlari, Thomas; Swindles, Graeme T; Galloway, Jennifer M; Bell, Kimberley M; Sulphur, Kyle C; Heaman, Larry M; Beranek, Luke P; Fallas, Karen M

    2015-01-01

    Detrital zircon studies are providing new insights on the evolution of sedimentary basins but the role of sedimentary recycling remains largely undefined. In a broad region of northwestern North America, this contribution traces the pathway of detrital zircon sand grains from Proterozoic sandstones through Phanerozoic strata and argues for multi-stage sedimentary recycling over more than a billion years. As a test of our hypothesis, integrated palynology and detrital zircon provenance provides clear evidence for erosion of Carboniferous strata in the northern Cordillera as a sediment source for Upper Cretaceous strata. Our results help to calibrate Earth's sedimentary cycle by showing that recycling dominates sedimentary provenance for the refractory mineral zircon. PMID:26658165

  11. Naturalistic speeding data: Drivers aged 75 years and older.

    Science.gov (United States)

    Chevalier, Anna; Chevalier, Aran John; Clarke, Elizabeth; Wall, John; Coxon, Kristy; Brown, Julie; Ivers, Rebecca; Keay, Lisa

    2016-09-01

    The data presented in this article are related to the research article entitled "A longitudinal investigation of the predictors of older drivers׳ speeding behavior" (Chevalier et al., 2016) [1], wherein these speed events were used to investigate older drivers speeding behavior and the influence of cognition, vision, functional decline, and self-reported citations and crashes on speeding behavior over a year of driving. Naturalistic speeding behavior data were collected for up to 52 weeks from volunteer drivers aged 75-94 years (median 80 years, 52% male) living in the suburban outskirts of Sydney. Driving data were collected using an in-vehicle monitoring device. Global Positioning System (GPS) data were recorded at each second and determined driving speed through triangulation of satellite collected location data. Driving speed data were linked with mapped speed zone data based on a service-provider database. To measure speeding behavior, speed events were defined as driving 1 km/h or more, with a 3% tolerance, above a single speed limit, averaged over 30 s. The data contains a row per 124,374 speed events. This article contains information about data processing and quality control. PMID:27294182

  12. Hematite formation by oxygenated groundwater more than 2.76 billion years ago

    Science.gov (United States)

    Kato, Yasuhiro; Suzuki, Katsuhiko; Nakamura, Kentaro; Hickman, Arthur H.; Nedachi, Munetomo; Kusakabe, Minoru; Bevacqua, David C.; Ohmoto, Hiroshi

    2009-02-01

    Geoscientific drilling in the Marble Bar area of the Pilbara Craton, Western Australia, resulted in the discovery of locally abundant hematite in Archean basalts ~ 200 m below the present land surface. The hematized basalts occurring along a bedding-parallel shear zone are cross-cut by pyrite veinlets (< 3 mm in width) and contain euhedral pyrite grains (10-500 µm in diameter) with sharp crystal edges, indicating that the hematite formed before the pyrite. We have dated the pyrite in the veinlets at 2.763 ± 0.016 Ga using the Re-Os method. Therefore, the hematite formed prior to 2.763 Ga. The basalts containing the hematite belong to the Apex Basalt of the Warrawoona Group, and were erupted onto the Archean seafloor at 3.46 Ga. Due to 2.9 Ga orogenic deformation and subsequent deep erosion, the Apex Basalt was exposed at the surface of a continental landmass prior to 2.77 Ga. Sometime in the period between ~ 2.9 Ga and 2.77 Ga, the basalt section we describe was less than 200 m below the Late Archean land surface, and within range of groundwater percolation through the shear zone in the basalts. Geological, mineralogical and geochemical lines of evidence strongly suggest that the infiltration of O 2-rich groundwater through the bedding-parallel shear in the basalts formed hematite prior to 2.76 Ga, and hence oxygenated surface environments, at least localized and/or short-lived, emerged more than 300 million years before the widely accepted Great Oxidation Event during 2.45 and 2.32 Ga.

  13. Transplantation With Livers From Deceased Donors Older Than 75 Years

    DEFF Research Database (Denmark)

    Thorsen, Trygve; Aandahl, Einar Martin; Bennet, William;

    2015-01-01

    BACKGROUND: The availability of donor organs limits the number of patients in need who are offered liver transplantation. Measures to expand the donor pool are crucial to prevent on-list mortality. The aim of this study was to evaluate the use of livers from deceased donors who were older than 75...... years. METHODS: Fifty-four patients who received a first liver transplant (D75 group) from 2001 to 2011 were included. Donor and recipient data were collected from the Nordic Liver Transplant Registry and medical records. The outcome was compared with a control group of 54 patients who received a liver...... higher in the D75 group (29.6/13%, P = 0.03). CONCLUSIONS: Selected livers from donors over age 75 years should not be excluded based on age, which does not compromise patient or graft survival despite a higher frequency of biliary complications....

  14. Taking out 1 billion tons of CO2: The magic of China's 11th Five-Year Plan?

    International Nuclear Information System (INIS)

    China's 11th Five-Year Plan (FYP) sets an ambitious target for energy-efficiency improvement: energy intensity of the country's gross domestic product (GDP) should be reduced by 20% from 2005 to 2010 [National Development and Reform Commission (NDRC), 2006. Overview of the 11th Five Year Plan for National Economic and Social Development. NDRC, Beijing]. This is the first time that a quantitative and binding target has been set for energy efficiency, and signals a major shift in China's strategic thinking about its long-term economic and energy development. The 20% energy-intensity target also translates into an annual reduction of over 1.5 billion tons of CO2 by 2010, making the Chinese effort one of the most significant carbon mitigation efforts in the world today. While it is still too early to tell whether China will achieve this target, this paper attempts to understand the trend in energy intensity in China and to explore a variety of options toward meeting the 20% target using a detailed end-use energy model

  15. Mobile hydrocarbon microspheres from >2-billion-year-old carbon-bearing seams in the South African deep subsurface.

    Science.gov (United States)

    Wanger, G; Moser, D; Hay, M; Myneni, S; Onstott, T C; Southam, G

    2012-11-01

    By ~2.9 Ga, the time of the deposition of the Witwatersrand Supergroup, life is believed to have been well established on Earth. Carbon remnants of the microbial biosphere from this time period are evident in sediments from around the world. In the Witwatersrand Supergroup, the carbonaceous material is often concentrated in seams, closely associated with the gold deposits and may have been a mobile phase 2 billion years ago. Whereas today the carbon in the Witwatersrand Supergroup is presumed to be immobile, hollow hydrocarbon spheres ranging in size from 50 μm were discovered emanating from a borehole drilled through the carbon-bearing seams suggesting that a portion of the carbon may still be mobile in the deep subsurface. ToF-SIMS and STXM analyses revealed that these spheres contain a suite of alkane, alkenes, and aromatic compounds consistent with the described organic-rich carbon seams within the Witwatersrand Supergroup's auriferous reef horizons. Analysis by electron microscopy and ToF-SIMS, however, revealed that these spheres, although most likely composed of biogenic carbon and resembling biological organisms, do not retain any true structural, that is, fossil, information and were formed by an abiogenic process. PMID:22901282

  16. Ten years of integrated care for the older in France

    Directory of Open Access Journals (Sweden)

    Dominique Somme

    2011-12-01

    Full Text Available Background: This paper analyzes progress made toward the integration of the French health care system for the older and chronically ill population. Policies: Over the last ten years, the French health care system has been principally influenced by two competing linkage models that failed to integrate social and health care services: local information and coordination centers, governed by the social field, and the gerontological health networks governed by the health field. In response to this fragmentation, Homes for the Integration and Autonomy for Alzheimer patients (MAIAs is currently being implemented at experimental sites in the French national Alzheimer plan, using an evidence-based model of integrated care. In addition, the state's reforms recently created regional health agencies (ARSs by merging seven strategic institutions to manage the overall delivery of care. Conclusion: The French health care system is moving from a linkage-based model to a more integrated care system. We draw some early lessons from these changes, including the importance of national leadership and governance and a change management strategy that uses both top-down and bottom-up approaches to implement these reforms.

  17. Shoulder dislocation in patients older than 60 years of age

    Directory of Open Access Journals (Sweden)

    Rapariz Jose

    2010-01-01

    Full Text Available Purpose: Recurrent anterior shoulder dislocation in elderly patients is a little studied condition. The goal of this paper is to clarify the role of associated injuries with respect to loss of function and recurrence of dislocation. Materials and Methods: We have conducted a retrospective, descriptive study on 29 patients older than 60 years at the moment they suffered their first dislocation episode. All patients were assessed clinically (Constant test and by imaging testing (X-ray, MRI. Results: Nine (31.03% out of 29 patients had a recurrent dislocation. Four of them required reconstructive surgery to maintain joint stability. Injury to the anterior support (anterior labrum, anterior glenoid rim showed a statistically significant relation to the recurrence of dislocations. The occurrence or non-occurrence of a rotator cuff tear does have an impact on the shoulder function. The degree of rotator cuff involvement on the coronal plane does not significantly affect the shoulder′s functional outcome. The tear extension on the sagittal plane does cause impairment on the Constant test. Conclusions: Labrum and/or anterior glenoid involvement should be suspected in elderly patients presenting with recurrent shoulder dislocation. Recurrence is due to an injury in the anterior support or both (anterior and posterior, even though shoulder function gets impaired when a rotation cuff tear occurs with anterior extension on the sagittal plane. Evidence level: IV Case series.

  18. Shandong Plans to Cultivate Two Aluminum Industry Groups with Sales Income Topping 100 billion yuan Within Three Years

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Recently,Shandong Province unveiled"Nonferrous Industry Transition and Upgrading Plan",which proposed that by 2017 it would cultivate 2 ultra large aluminum industry groups with sales income topping 100 billion yuan,aluminum capacity will be reduced to 9million tonnes;before 2020 it will no longer add new capacity.

  19. Deposition of 1.88-billion-year-old iron formations as a consequence of rapid crustal growth.

    Science.gov (United States)

    Rasmussen, Birger; Fletcher, Ian R; Bekker, Andrey; Muhling, Janet R; Gregory, Courtney J; Thorne, Alan M

    2012-04-26

    Iron formations are chemical sedimentary rocks comprising layers of iron-rich and silica-rich minerals whose deposition requires anoxic and iron-rich (ferruginous) sea water. Their demise after the rise in atmospheric oxygen by 2.32 billion years (Gyr) ago has been attributed to the removal of dissolved iron through progressive oxidation or sulphidation of the deep ocean. Therefore, a sudden return of voluminous iron formations nearly 500 million years later poses an apparent conundrum. Most late Palaeoproterozoic iron formations are about 1.88 Gyr old and occur in the Superior region of North America. Major iron formations are also preserved in Australia, but these were apparently deposited after the transition to a sulphidic ocean at 1.84 Gyr ago that should have terminated iron formation deposition, implying that they reflect local marine conditions. Here we date zircons in tuff layers to show that iron formations in the Frere Formation of Western Australia are about 1.88 Gyr old, indicating that the deposition of iron formations from two disparate cratons was coeval and probably reflects global ocean chemistry. The sudden reappearance of major iron formations at 1.88 Gyr ago--contemporaneous with peaks in global mafic-ultramafic magmatism, juvenile continental and oceanic crust formation, mantle depletion and volcanogenic massive sulphide formation--suggests deposition of iron formations as a consequence of major mantle activity and rapid crustal growth. Our findings support the idea that enhanced submarine volcanism and hydrothermal activity linked to a peak in mantle melting released large volumes of ferrous iron and other reductants that overwhelmed the sulphate and oxygen reservoirs of the ocean, decoupling atmospheric and seawater redox states, and causing the return of widespread ferruginous conditions. Iron formations formed on clastic-starved coastal shelves where dissolved iron upwelled and mixed with oxygenated surface water. The

  20. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    Institute of Scientific and Technical Information of China (English)

    Li Mo; Ding Ding; Shi-Yun Pu; Qin-Hui Liu; Hong Li; Bi-Rong Dong; Xiao-Yan Yang

    2016-01-01

    Background: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients.This study was to investigate the different prevalence of PIM use in elderly inpatients between 65-79 years of age and 80 years or older, who were discharged from Geriatric Department in West China Hospital.Methods: A large-scale cohort of 1796 inpatients aged 65 years or over was recruited.Respectively, 618 patients were 65-79 years and 1 178 patients were 80 years or older.Updated 2012 Beers Criteria by the American Geriatric Society was applied to assess the use of PIM among the investigated samples.Results: A review of the prescribed medications identified 686 patients aged 80 years or older consumed at least one PIM giving a rate of 58.2%.Conversely, 268 (43.4%) patients aged 65-79 years consumed at least one PIM (x2 =40.18, P < 0.001).Patients aged 80 years or older had higher hospitalization expenses, length of stay, co-morbidities, medical prescription, and mortality than patients aged 65-79 years (all with P < 0.001).Patients aged 80 years or older were prescribed with more benzodiazepines, drugs with strong anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin.In multiple regression analysis, PIM use was significantly associated with female gender, age, number of diagnostic disease, and number of prescribed medication.Conclusions: The finding from this study revealed that inpatients aged 80 years or older encountered more PIM use than those aged 65-79 years.Anticholinergic properties, megestrol, antipsychotics, theophylline, and aspirin are medications that often prescribed to inpatients aged 80 years or older.Doctors should carefully choose drugs for the elderly, especially the elderly aged 80 years or older.

  1. Asthma Prevalence, Adults (18 and older) by Year, 1995 to 2010

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset contains the estimated percent of California adults (18 and older) with lifetime and current asthma (asthma prevalence), by year. The data are derived...

  2. Impact of Social Capital on 8-year Mortality Among Older People in 34 Danish Municipalities

    DEFF Research Database (Denmark)

    Poulsen, Tine; Siersma, Volkert Dirk; Christensen, Ulla;

    2012-01-01

    To analyze the impact of social capital measures (bonding, bridging, and linking) on all-cause mortality at 8-year follow-up among older people aged 75 and 80 at baseline.......To analyze the impact of social capital measures (bonding, bridging, and linking) on all-cause mortality at 8-year follow-up among older people aged 75 and 80 at baseline....

  3. Social participation reduces depressive symptoms among older adults: An 18-year longitudinal analysis in Taiwan

    Directory of Open Access Journals (Sweden)

    Botticello Amanda L

    2011-05-01

    Full Text Available Abstract Background Relatively little empirical attention has focused on the association between social participation and depressive symptoms amongst older adults in Asian nations, where persons over the age of 65 represent a rapidly growing segment of the population. This study explores the dynamic relationship between participation in social activities and trajectories of depressive symptomatology among older Taiwanese adults surveyed over 18 years. Methods Data are from a nationally representative sample of 1,388 adults aged 60-64 first surveyed in 1989 and followed over an 18-year time period for a total of six waves. Individual involvement in social activities was categorized into continuous participation, ceased participation before age 70, initiating participation in older adulthood, never participated, and dropped out before age 70. Two domains of depressive symptoms--negative affect and lack of positive affect--were measured using a 10-item version of the Center for Epidemiologic Studies-Depression Scale. Results Analyses using growth curve modeling showed that continuously participating or initiating participation in social activities later life is significantly associated with fewer depressive symptoms among older Taiwanese adults, even after controlling for the confounding effects of aging, individual demographic differences, and health status. Conclusions These findings suggest that maintaining or initiating social participation in later life benefits the mental health of older adults. Facilitating social activities among older adults is a promising direction for programs intended to promote mental health and successful aging among older adults in Taiwan.

  4. Three-year outcome of alendronate treatment in older Japanese women with osteoporosis

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2012-10-01

    Full Text Available The effects of alendronate (ALN treatment on the bone mineral density (BMD, bone turnover markers, and fracture incidence remain to be established in older Japanese patients. The aim of the present study was to compare the outcome of ALN treatment for 3 years among postmenopausal osteoporotic Japanese women <80 years of age and those ≥80 years of age. One hundred ninety-eight postmenopausal osteoporotic women who had been treated with ALN for more than 3 years were analyzed. The 3-year outcome was compared between women <80 years of age (control group, n=167 and those ≥80 years of age (older group, n=31. During the 3-year treatment period, the urinary cross-linked N-terminal telopeptides of the type I collagen and serum alkaline phosphatase levels significantly decreased and the lumbar spine BMD significantly increased, compared with the baseline values, in manners that were similar in the control and older groups. However, the incidence of non-vertebral fractures, but not of vertebral fractures, was significantly higher in the older group than in the control group (16.1% vs 3.0%. These results suggested that the incidence of non-vertebral fractures was significantly higher among postmenopausal osteoporotic Japanese women ≥80 years of age who were treated with ALN than among those <80 years of age despite the similar effect of ALN treatment on surrogate markers.

  5. State Funds for Higher Education Total $34-Billion; 11-Pct. Biennial Rise Equals Lowest in 29 Years.

    Science.gov (United States)

    Jaschik, Scott

    1987-01-01

    Tight state budgets and regional economic difficulties have prompted a sharp drop in the rate that state appropriations for higher education have increased over the past two years. New England fares well while farm and oil states suffer. (MLW)

  6. Quarter One:36.25 Billion USD

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    From January to March,2007,China’s total international trade value was 457.74 billion US dollars,and the rise was 23.3% compared with last year.The import made to 205.65 billion US dollars and the export was 252.09 billion US dollars,up

  7. Long-term mortality in HIV-infected individuals 50 years or older

    DEFF Research Database (Denmark)

    Legarth, Rebecca; Ahlström, Magnus G; Kronborg, Gitte;

    2016-01-01

    BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older,...

  8. Arthroscopically assisted osteosynthesis of tibial plateau fractures in patients older than 55 years

    NARCIS (Netherlands)

    Roerdink, WH; Oskam, J; Vierhout, PAM

    2001-01-01

    Purpose: To evaluate the end results of arthroscopically assisted osteosynthesis of tibial plateau fractures in patients older than 55 years of age. Type of Study: Case series. Methods: Over a 5-year period, 201 consecutive patients presented with tibial plateau fracture; 131 of these patients were

  9. Physical and cognitive functioning of people older than 90 years

    DEFF Research Database (Denmark)

    Christensen, Kaare; Thinggaard, Mikael; Oksuzyan, Anna;

    2013-01-01

    A rapidly increasing proportion of people in high-income countries are surviving into their tenth decade. Concern is widespread that the basis for this development is the survival of frail and disabled elderly people into very old age. To investigate this issue, we compared the cognitive and phys......A rapidly increasing proportion of people in high-income countries are surviving into their tenth decade. Concern is widespread that the basis for this development is the survival of frail and disabled elderly people into very old age. To investigate this issue, we compared the cognitive...... and physical functioning of two cohorts of Danish nonagenarians, born 10 years apart....

  10. Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use

    OpenAIRE

    Li Mo; Ding Ding; Shi-Yun Pu; Qin-Hui Liu; Hong Li; Bi-Rong Dong; Xiao-Yan Yang; Jin-Han He

    2016-01-01

    Background: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. This study was to investigate the different prevalence of PIM use in elderly inpatients between 65-79 years of age and 80 years or older, who were discharged from Geriatric Department in West China Hospital. Methods: A large-scale cohort of 1796 inpatients aged 65 years or over was recruited. Respectively, 618 patients were 65-79 years and 1178 patients were 80 y...

  11. Taking out one billion tones of carbon: the magic of China's 11th Five-Year Plan

    OpenAIRE

    Lin, Jiang; Zhou, Nan; Levine, Mark D.; Fridley, David

    2007-01-01

    China's 11th Five-Year Plan (FYP) sets an ambitious target for energy-efficiency improvement: energy intensity of the country s gross domestic product (GDP) should be reduced by 20 percent from 2005 to 2010 (NDRC, 2006). This is the first time that a quantitative and binding target has been set for energy efficiency, and signals a major shift in China's strategic thinking about its long-term economic and energy development. The 20 percent energy intensity target also translates into an a...

  12. Diabetic retinopathy in people aged 70 years or older. The Oulu Eye Study

    OpenAIRE

    Hirvela, H.; Laatikainen, L

    1997-01-01

    AIMS—To evaluate the presence and severity of diabetic retinopathy and the value of retinopathy screening in people aged 70 years or older.
METHODS—In a population based study on 500 of 560 eligible (89%) people aged 70 years or older, signs of diabetic retinopathy were evaluated through dilated pupils by an ophthalmologist using photographic and/or ophthalmoscopic methods.
RESULTS—23% of the study population (113/500) had diabetes mellitus. Signs of diabetic retinopathy were found in 24 peop...

  13. The Evolution of the Galaxy Rest-Frame Ultraviolet Luminosity Function Over the First Two Billion Years

    CERN Document Server

    Finkelstein, Steven L; Papovich, Casey; Dickinson, Mark; Song, Mimi; Somerville, Rachel; Ferguson, Henry C; Salmon, Brett; Giavalisco, Mauro; Koekemoer, Anton M; Ashby, Matthew L N; Behroozi, Peter; Castellano, Marco; Dunlop, James S; Faber, Sandy M; Fazio, Giovanni G; Fontana, Adriano; Grogin, Norman A; Hathi, Nimish; Jaacks, Jason; Kocevski, Dale D; Livermore, Rachael; McLure, Ross J; Merlin, Emiliano; Mobasher, Bahram; Newman, Jeffrey A; Rafelski, Marc; Tilvi, Vithal; Willner, S P

    2014-01-01

    We present a robust measurement and analysis of the rest-frame ultraviolet (UV) luminosity function at z=4-8. We use deep Hubble Space Telescope imaging over the CANDELS/GOODS fields, the Hubble Ultra Deep Field and the Year 1 Hubble Frontier Field deep parallel observations. These surveys provides an effective volume of 0.6-1.2 x 10^6 Mpc^3 over this epoch, allowing us to perform a robust search for bright (M_UV 1000 galaxies at z~6-8. We measure the luminosity function using a Markov Chain Monte Carlo analysis to measure robust uncertainties. At the faint end our results agree with previous studies, yet we find a higher abundance of UV-bright galaxies at z>6, with M* ~ -21 at z>5, different than that inferred based on previous trends at lower redshift. At z=8, a single power-law provides an equally good fit to the UV luminosity function, while at z=6 and 7, an exponential cutoff at the bright-end is moderately preferred. We compare to semi-analytical models, and find that the lack of evolution in M* is cons...

  14. Geriatric conditions in acutely hospitalized older patients: prevalence and one-year survival and functional decline.

    Directory of Open Access Journals (Sweden)

    Bianca M Buurman

    Full Text Available BACKGROUND: To study the prevalence of eighteen geriatric conditions in older patients at admission, their reporting rate in discharge summaries and the impact of these conditions on mortality and functional decline one year after admission. METHOD: A prospective multicenter cohort study conducted between 2006 and 2008 in two tertiary university teaching hospitals and one regional teaching hospital in the Netherlands. Patients of 65 years and older, acutely admitted and hospitalized for at least 48 hours, were invited to participate. Eighteen geriatric conditions were assessed at hospital admission, and outcomes (mortality, functional decline were assessed one year after admission. RESULTS: 639 patients were included, with a mean age of 78 years. IADL impairment (83%, polypharmacy (61%, mobility difficulty (59%, high levels of primary caregiver burden (53%, and malnutrition (52% were most prevalent. Except for polypharmacy and cognitive impairment, the reporting rate of the geriatric conditions in discharge summaries was less than 50%. One year after admission, 35% had died and 33% suffered from functional decline. A high Charlson comorbidity index score, presence of malnutrition, high fall risk, presence of delirium and premorbid IADL impairment were associated with mortality and overall poor outcome (mortality or functional decline. Obesity lowered the risk for mortality. CONCLUSION: Geriatric conditions were highly prevalent and associated with poor health outcomes after admission. Early recognition of these conditions in acutely hospitalized older patients and improving the handover to the general practitioner could lead to better health outcomes and reduce the burden of hospital admission for older patients.

  15. Innovation and Involvement: 100 Years of Community Work with Older People.

    Science.gov (United States)

    Glasby, Jon

    2000-01-01

    Birmingham Settlement has provided services to British older adults for over 100 years, including such innovations as adult day centers, meals on wheels, and transportation services. The participation of the clientele in research helped flesh out the history of the settlement through narratives that demonstrate its impact on the life of the…

  16. A Model for Partnering First-Year Student Pharmacists With Community-Based Older Adults

    OpenAIRE

    Martin, Beth A.; Porter, Andrea L.; Shawl, Lauren; Motl Moroney, Susannah E.

    2012-01-01

    Objectives. To design, integrate, and assess the effectiveness of an introductory pharmacy practice experience intended to redefine first-year student pharmacists’ views on aging and medication use through their work with a healthy, community-based older-adult population.

  17. Oral nutritional support of older (65 years+) medical and surgical patients after discharge from hospital

    DEFF Research Database (Denmark)

    Beck, Anne Marie; Holst, Mette; Rasmussen, Henrik Højgaard

    2013-01-01

    To estimate the effectiveness of oral nutritional support compared to placebo or usual care in improving clinical outcome in older (65 years+) medical and surgical patients after discharge from hospital. Outcome goals were: re-admissions, survival, nutritional and functional status, quality of life...

  18. Development of health over four years among middle-aged and older Europeans

    DEFF Research Database (Denmark)

    Vestergaard, Sonja; Eriksen, Mette Lindholm; Andersen-Ranberg, Karen

    Older adults in Eastern and Central European countries have a higher risk of developing poor self-rated health over four years. The same geographical pattern is seen for a higher risk of developing hypertension and diabetes. Low educational level significantly increases the risk of developing poor...

  19. Geriatric Conditions in Acutely Hospitalized Older Patients: Prevalence and One-Year Survival and Functional Decline

    NARCIS (Netherlands)

    B.M. Buurman; J.G. Hoogerduijn; R.J. de Haan; A. Abu-Hanna; A.M. Lagaay; H.J. Verhaar; M.J. Schuurmans; M. Levi; S.E. de Rooij

    2011-01-01

    Background: To study the prevalence of eighteen geriatric conditions in older patients at admission, their reporting rate in discharge summaries and the impact of these conditions on mortality and functional decline one year after admission. Method: A prospective multicenter cohort study conducted b

  20. Five years later: resiliency among older adult survivors of Hurricane Katrina.

    Science.gov (United States)

    Hrostowski, Susan; Rehner, Timothy

    2012-01-01

    The purpose of this study was to examine the resilience of older adult survivors of Hurricane Katrina in light of their traumatic experiences and multiple losses. Ten Mississippi Gulf Coast residents who have survived Hurricane Katrina and its aftermath were interviewed. The participants were 65 years old or older. Their responses were audiotaped and transcribed. The transcripts were analyzed using phenomenological methodology and NVivo 2.5 software. Three major themes emerged. Participants described finding personal gratification, realizing their ability to cope, and developing a new interest in life through their novel experiences. PMID:22574866

  1. Sexual risk behaviors and HIV risk among Americans aged 50 years or older: a review

    Directory of Open Access Journals (Sweden)

    Pilowsky DJ

    2015-04-01

    Full Text Available Daniel J Pilowsky,1,2 Li-Tzy Wu3,41Columbia University Medical Center, Department of Epidemiology, Mailman School of Public Health New York City, NY, USA; 2Division of Epidemiology, New York State Psychiatric Institute, New York City, NY, USA; 3Department of Psychiatry and Behavioral Sciences, School of Medicine, 4Center for Child and Family Policy, Duke University, Durham, NC, USAAbstract: Although HIV-related sexual risk behaviors have been studied extensively in adolescents and young adults, there is limited information about these behaviors among older Americans, which make up a growing segment of the US population and an understudied population. This review of the literature dealing with sexual behaviors that increase the risk of becoming HIV-infected found a low prevalence of condom use among older adults, even when not in a long-term relationship with a single partner. A seminal study by Schick et al published in 2010 reported that the prevalence of condom use at last intercourse was highest among those aged 50–59 years (24.3%; 95% confidence interval, 15.6–35.8 and declined with age, with a 17.1% prevalence among those aged 60–69 years (17.1%; 95% confidence interval, 7.3–34.2. Studies have shown that older Americans may underestimate their risk of becoming HIV-infected. Substance use also increases the risk for sexual risk behaviors, and studies have indicated that the prevalence of substance use among older adults has increased in the past decade. As is the case with younger adults, the prevalence of HIV infections is elevated among ethnic minorities, drug users (eg, injection drug users, and men who have sex with men. When infected, older adults are likely to be diagnosed with HIV-related medical disorders later in the course of illness compared with their younger counterparts. Physicians are less likely to discuss sexual risk behaviors with older adults and to test them for HIV compared with younger adults. Thus, it is

  2. Health-Engagement Control Strategies and 2-Year Changes in Older Adults’ Physical Health

    Science.gov (United States)

    Wrosch, Carsten; Schulz, Richard

    2009-01-01

    This study examined the associations between older adults’ daily physical symptoms (e.g., chest pain or difficulty breathing) and 2-year changes in chronic health problems (e.g., cardiovascular disease or cancer) and in functional problems (e.g., difficulty dressing or moving around at home). We reasoned that these associations depend on a person’s active control processes aimed at counteracting physical health problems (i.e., health-engagement control strategies, or HECS). In particular, we hypothesized that high levels of HECS buffer the adverse effect of daily physical symptoms on increases in chronic and functional health problems. We found that daily physical symptoms were associated with declines in chronic and functional health among older adults who were not engaged in addressing their health problems, but not among their counterparts who reported high levels of HECS. These findings suggest that active control strategies play an important role in the maintenance of older adults’ physical health. PMID:18578842

  3. Palliative chemotherapy in advanced colorectal cancer patients 80 years of age and older

    Science.gov (United States)

    Lai, P.; Sud, S.; Zhang, T.; Asmis, T.; Wheatley-Price, P.

    2016-01-01

    Background Colorectal cancer (crc) has a median diagnostic age of 68 years. Despite significant progress in chemotherapy (ctx) options, few data on outcomes or toxicity from ctx in patients 80 years of age and older are available. We investigated ctx in such patients with metastatic crc (mcrc), hypothesizing high rates of hospitalization and toxicity. Methods A retrospective chart review identified patients 80 years of age and older with mcrc who initiated ctx between 2005–2010 at our institution. Patient demographics and ctx data were collected. Endpoints included rates of hospitalization, ctx discontinuation because of toxicity, and overall survival. Results In 60 patients, ctx was initiated on 88 occasions. Median age in the cohort was 83 years; 52% were men; 72% lived with family; 53% had a modified Charlson comorbidity index of 2 or greater; and 31% were taking 6 or more prescription medications at baseline. At baseline, 33% of the patients were anemic (hemoglobin 11×109/L), and 48% had renal impairment (estimated glomerular filtration rate < 60 mL/min/1.73 m2). In 53%, ctx was given as first-line treatment. The initial ctx dose was adjusted in 67%, and capecitabine was the most common chemotherapeutic agent (45%). In 19 instances (22%), the patient was hospitalized during or within 30 days of ctx; in 26 instances (30%), the ctx was discontinued because of toxicity, and in 48 instances (55%), the patient required at least 1 dose reduction, omission, or delay. Median overall survival was 17.8 months (95% confidence interval: 14.3 to 20.8 months). Conclusions In the population 80 years of age and older, ctx for mcrc is feasible; however, most recipients will require dose adjustments, and a significant proportion will be hospitalized or stop ctx because of toxicity. Prospective research incorporating geriatric assessment tools is required to better select these older patients for ctx. PMID:27330342

  4. Long-Term Exercise in Older Adults: 4-Year Outcomes of Music-Based Multitask Training

    OpenAIRE

    Hars, Mélany; Herrmann, François R.; Fielding, Roger A.; Reid, Kieran F.; Rizzoli, René; Trombetti, Andrea

    2014-01-01

    Prospective controlled evidence supporting the efficacy of long-term exercise to prevent physical decline and reduce falls in old age is lacking. The present study aimed to assess the effects of long-term music-based multitask exercise (i.e., Jaques-Dalcroze eurhythmics) on physical function and fall risk in older adults. A 3-year follow-up extension of a 1-year randomized controlled trial (NCT01107288) was conducted in Geneva (Switzerland), in which 134 community-dwellers aged ≥65 years at i...

  5. Health-Engagement Control Strategies and 2-Year Changes in Older Adults’ Physical Health

    OpenAIRE

    Wrosch, Carsten; Schulz, Richard

    2008-01-01

    This study examined the associations between older adults’ daily physical symptoms (e.g., chest pain or difficulty breathing) and 2-year changes in chronic health problems (e.g., cardiovascular disease or cancer) and in functional problems (e.g., difficulty dressing or moving around at home). We reasoned that these associations depend on a person’s active control processes aimed at counteracting physical health problems (i.e., health-engagement control strategies, or HECS). In particular, we ...

  6. State carries takes another billions from SPP

    International Nuclear Information System (INIS)

    Financial aspects of activities of the SPP, a.s. are analysed. Economising of SPP of last year means income of 7.8 billions Slovak crowns for exchequer. Besides 3.9 billion of last year's taxes from income the state benefits will be doubled this year. The reason of increase are the dividends which account for 51% share of profit after distinctive deliveries from record clean profit of 8.7 billions Slovak crowns. Dividing of company profit, which doubled in last year to 12.6 billions Slovak crowns was adopted by shareholders in the last week at general assembly of SPP. Gaz de France and Ruhrgas who really began to manage the company in the second half of 2002 will divide remaining 3.7 billions Slovak crowns. (Author)

  7. Effects of integrated dental care on oral treatment needs in residents of nursing homes older than 70 years

    NARCIS (Netherlands)

    Gerritsen, Paul; Cune, Marco; van der Bilt, Andries; Abbink, Jan; de Putter, Cornelis

    2015-01-01

    Aim: To determine effects of integrated dental care in older nursing home residents. Methods: In three nursing homes offering integrated dental care, we studied the oral treatment need of 355 residents older than 70 years. To determine effects of integrated care, we discriminated between short-stay

  8. Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

    DEFF Research Database (Denmark)

    McDonald, Cameron Keith; Ankarfeldt, Mikkel Z; Capra, Sandra;

    2016-01-01

    adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were......Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older...... and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss...

  9. Objectively Measured Walking Duration and Sedentary Behaviour and Four-Year Mortality in Older People

    Science.gov (United States)

    Denkinger, Michael Dieter; Rapp, Kilian; Koenig, Wolfgang; Rothenbacher, Dietrich

    2016-01-01

    Background Physical activity is an important component of health. Recommendations based on sensor measurements are sparse in older people. The aim of this study was to analyse the effect of objectively measured walking and sedentary duration on four-year mortality in community-dwelling older people. Methods Between March 2009 and April 2010, physical activity of 1271 participants (≥65 years, 56.4% men) from Southern Germany was measured over one week using a thigh-worn uni-axial accelerometer (activPAL; PAL Technologies, Glasgow, Scotland). Mortality was assessed during a four-year follow-up. Cox-proportional-hazards models were used to estimate the associations between walking (including low to high intensity) and sedentary duration with mortality. Models were adjusted for age and sex, additional epidemiological variables, and selected biomarkers. Results An inverse relationship between walking duration and mortality with a minimum risk for the 3rd quartile (102.2 to128.4 minutes walking daily) was found even after multivariate adjustment with HRs for quartiles 2 to 4 compared to quartile 1 of 0.45 (95%-CI: 0.26; 0.76), 0.18 (95%-CI: 0.08; 0.41), 0.39 (95%-CI: 0.19; 0.78), respectively. For sedentary duration an age- and sex-adjusted increased mortality risk was observed for the 4th quartile (daily sedentary duration ≥1137.2 min.) (HR 2.05, 95%-CI: 1.13; 3.73), which diminished, however, after full adjustment (HR 1.63, 95%-CI: 0.88; 3.02). Furthermore, our results suggest effect modification between walking and sedentary duration, such that in people with low walking duration a high sedentary duration was noted as an independent factor for increased mortality. Conclusions In summary, walking duration was clearly associated with four-year overall mortality in community-dwelling older people. PMID:27082963

  10. Effects of Organized Physical Activity on Selected Health Indices among Women Older than 55 Years

    Directory of Open Access Journals (Sweden)

    Piotr Zmijewski

    2015-01-01

    Full Text Available The main aim of this study was to determine health benefits among women older than 55 years who participated in organized, group-based physical activity (OPA. Thirty-five women aged 65.0 ± 7.3 years volunteered for this study. The classical and nonclassical cardiovascular (CVD risk factors were measured before and after a 2-week OPA camp in a remote location and 3 months of OPA. Self-guided physical activity was analyzed 18 months after OPA. Two-week effects included significant decreases in body mass index, waist and hip circumferences, resting systolic and diastolic blood pressure (BP and resting heart rate, improved exercise capacity (EC, improved low-density lipoprotein and high-density lipoprotein (HDL-C, cholesterol, and other atherogenic lipid indices (ALI, and a reduction in 10-year estimated risk of death from CVD. Three-month effects included a further decrease in systolic BP, improvements in EC and HDL-C, and maintenance of lower levels of ALI, as well as lower CVD risk. The implementation of the OPA programme had a positive impact on somatic features, exercise capacity, biochemical indices, and risk for death from CVD. The presented programme can be regarded as an effective element of primary prevention of cardiovascular diseases among women older than 55 years.

  11. Adiposity predicts cognitive decline in older persons with diabetes: a 2-year follow-up.

    Directory of Open Access Journals (Sweden)

    Angela Marie Abbatecola

    Full Text Available BACKGROUND: The mechanisms related to cognitive impairment in older persons with Type 2 diabetes (DM remains unclear. We tested if adiposity parameters and body fat distribution could predict cognitive decline in older persons with DM vs. normal glucose tolerance (NGT. METHODOLOGY: 693 older persons with no dementia were enrolled: 253 with DM in good metabolic control; 440 with NGT (age range:65-85 years. Longitudinal study comparing DM and NGT individuals according to the association of baseline adiposity parameters (body mass index (BMI, waist-hip-ratio (WHR, waist circumference (WC and total body fat mass to cognitive change (Mini Mental State Examination (MMSE, a composite score of executive and attention functioning (CCS over time. FINDINGS: At baseline, in DM participants, MMSE correlated with WHR (beta = -0.240; p = 0.043, WC (beta = -0.264; p = 0.041 while CCS correlated with WHR (beta = -0.238; p = 0.041, WC (beta = -0.326; p = 0.013 after adjusting for confounders. In NGT subjects, no significant correlations were found among any adiposity parameters and MMSE, while CCS was associated with WHR (beta = -0.194; p = 0.036 and WC (beta = -0.210; p = 0.024. Participants with DM in the 3(rd tertile of total fat mass showed the greatest decline in cognitive performance compared to those in 1(st tertile (tests for trend: MMSE(p = 0.007, CCS(p = 0.003. Logistic regression models showed that 3(rd vs. 1(st tertile of total fat mass, WHR, and WC predicted an almost two-fold decline in cognitive function in DM subjects at 2(nd yr (OR 1.68, 95%IC 1.08-3.52. CONCLUSIONS: Total fat mass and central adiposity predict an increased risk for cognitive decline in older person with DM.

  12. Paravertebral block for patients older than 80 years in one day surgery elective mastectomy.

    Science.gov (United States)

    Compagnone, Christian; Schiappa, Eleonora; Bellantonio, Daniele; Ghirardi, Gianluca; Rossini, Elisabetta; Tagliaferri, Fernanda; Fanelli, Guido

    2013-12-01

    Paravertebral block (PVB) has been proposed as an alternative to General anaesthesia (GA) for breast surgery. It provides good operative anaesthesia, good pain control with little adverse effects. Six women older than 80 year were selected. All patients were post-operatively interviewed about the presence of pain, nausea and vomiting. All patients declared absence of pain and nausea and that they were satisfied with the procedure. The use of PVB allows elderly patients to undergo ambulatory surgery for the treatment of breast cancer with satisfaction. This technique allows a short recovery and adequate postoperative pain relief with reduced hospital costs. PMID:24458169

  13. Long-term exercise in older adults: 4-year outcomes of music-based multitask training.

    Science.gov (United States)

    Hars, Mélany; Herrmann, François R; Fielding, Roger A; Reid, Kieran F; Rizzoli, René; Trombetti, Andrea

    2014-11-01

    Prospective controlled evidence supporting the efficacy of long-term exercise to prevent physical decline and reduce falls in old age is lacking. The present study aimed to assess the effects of long-term music-based multitask exercise (i.e., Jaques-Dalcroze eurhythmics) on physical function and fall risk in older adults. A 3-year follow-up extension of a 1-year randomized controlled trial (NCT01107288) was conducted in Geneva (Switzerland), in which 134 community-dwellers aged ≥65 years at increased risk of falls received a 6-month music-based multitask exercise program. Four years following original trial enrolment, 52 subjects (baseline mean ± SD age, 75 ± 8 years) who (i) have maintained exercise program participation through the 4-year follow-up visit ("long-term intervention group", n = 23) or (ii) have discontinued participation following original trial completion ("control group", n = 29) were studied. They were reassessed in a blind fashion, using the same procedures as at baseline. At 4 years, linear mixed-effects models showed significant gait (gait speed, P = 0.006) and balance (one-legged stance time, P = 0.015) improvements in the long-term intervention group, compared with the control group. Also, long-term intervention subjects did better on Timed Up & Go, Five-Times-Sit-to-Stand and handgrip strength tests, than controls (P music-based multitask exercise program is a promising strategy to prevent age-related physical decline in older adults. They also highlight the efficacy of sustained long-term adherence to exercise for falls prevention. PMID:25148876

  14. Lamellar magnetism and exchange bias in billion-year-old titanohematite with nanoscale ilmenite exsolution lamellae: I. Mineral and magnetic characterization

    Science.gov (United States)

    McEnroe, Suzanne A.; Robinson, Peter; Miyajima, Nobuyoshi; Fabian, Karl; Dyar, Darby; Sklute, Elizabeth

    2016-07-01

    Recent high-resolution aeromagnetic surveys in South Norway have revealed numerous remanent anomalies over Mesoproterozoic metamorphic rocks. Studies on the nature of the minerals that are the remanent carriers has led to discoveries of titanohematite samples with unusual magnetic properties caused by nanoscale exsolution lamellae with their related lamellar magnetism. Here we focus on a rock unit dominated by quartz-plagioclase-biotite granulite containing titanohematite grains with a strong lattice-preferred orientation parallel to regional foliation. When samples with their natural remanent magnetization (NRM), acquired nearly 1 billion years ago, are cooled to 10 K and hysteresis loops measured, these loops show bi-modal exchange bias caused by the magnetism induced within the ilmenite by antiferromagnetic coupling with the adjacent lamellar NRM. By contrast when the samples are cooled in a strong magnetic field (1.5 Tesla), this results in unimodal lamellar magnetism, and, below the TN of ilmenite it adopts a consistent negative orientation, giving rise to unimodal negative exchange bias of >500 mT. The results presented here cover the chemical and magnetic properties, Mossbauer results and transmission electron microscopy of the titanohematite and ilmenite lamellae. Initial magnetic experiments indicated the shifts found in the exchange-bias experiments were directly related to the orientation of the sample to the applied field and the initial state of the NRM. In most samples with these unusual magnetic properties, ilmenite lamellae could not be seen in an optical or a scanning electron microscope. However magnetic experiments gave proof of the presence of ilmenite, later confirmed by Mössbauer spectroscopy. Several attempts were made to identify ilmenite in TEM studies, finally successful in showing ilmenite lamellae parallel to (001) of hematite with thicknesses ˜1.2 to 1.7 nm and aspect ratios 7-13. Here we compare new TEM images and the magnetic

  15. Composition and syngeneity of molecular fossils from the 2.78 to 2.45 billion-year-old Mount Bruce Supergroup, Pilbara Craton, Western Australia

    Science.gov (United States)

    Brocks, Jochen J.; Buick, Roger; Logan, Graham A.; Summons, Roger E.

    2003-11-01

    Shales of very low metamorphic grade from the 2.78 to 2.45 billion-year-old (Ga) Mount Bruce Supergroup, Pilbara Craton, Western Australia, were analyzed for solvent extractable hydrocarbons. Samples were collected from ten drill cores and two mines in a sampling area centered in the Hamersley Basin near Wittenoom and ranging 200 km to the southeast, 100 km to the southwest and 70 km to the northwest. Almost all analyzed kerogenous sedimentary rocks yielded solvent extractable organic matter. Concentrations of total saturated hydrocarbons were commonly in the range of 1 to 20 ppm (μg/g rock) but reached maximum values of 1000 ppm. The abundance of aromatic hydrocarbons was ˜1 to 30 ppm. Analysis of the extracts by gas chromatography-mass spectrometry (GC-MS) and GC-MS metastable reaction monitoring (MRM) revealed the presence of n-alkanes, mid- and end-branched monomethylalkanes, ω-cyclohexylalkanes, acyclic isoprenoids, diamondoids, tri- to pentacyclic terpanes, steranes, aromatic steroids and polyaromatic hydrocarbons. Neither plant biomarkers nor hydrocarbon distributions indicative of Phanerozoic contamination were detected. The host kerogens of the hydrocarbons were depleted in 13C by 2 to 21‰ relative to n-alkanes, a pattern typical of, although more extreme than, other Precambrian samples. Acyclic isoprenoids showed carbon isotopic depletion relative to n-alkanes and concentrations of 2α-methylhopanes were relatively high, features rarely observed in the Phanerozoic but characteristic of many other Precambrian bitumens. Molecular parameters, including sterane and hopane ratios at their apparent thermal maxima, condensate-like alkane profiles, high mono- and triaromatic steroid maturity parameters, high methyladamantane and methyldiamantane indices and high methylphenanthrene maturity ratios, indicate thermal maturities in the wet-gas generation zone. Additionally, extracts from shales associated with iron ore deposits at Tom Price and Newman have

  16. Lamellar magnetism and exchange bias in billion-year-old titanohematite with nanoscale ilmenite exsolution lamellae: I. mineral and magnetic characterization

    Science.gov (United States)

    McEnroe, S. A.; Robinson, Peter; Miyajima, Nobuyoshi; Fabian, Karl; Dyar, Darby; Sklute, Elizabeth

    2016-04-01

    Recent high-resolution aeromagnetic surveys in South Norway have revealed numerous remanent anomalies over Mesoproterozoic metamorphic rocks. Studies on the nature of the minerals that are the remanent carriers has led to discoveries of titanohematite samples with unusual magnetic properties caused by nanoscale exsolution lamellae with their related lamellar magnetism. Here we focus on a rock unit dominated by quartz-plagioclase-biotite granulite containing titanohematite grains with a strong lattice-preferred orientation parallel to regional foliation. When samples with their natural remanent magnetization (NRM), acquired nearly 1 billion years ago, are cooled to 10 K and hysteresis loops measured, these loops show bi-modal exchange bias caused by the magnetism induced within the ilmenite by antiferromagnetic coupling with the adjacent lamellar NRM. By contrast when the samples are cooled in a strong magnetic field (1.5 Tesla), this results in unimodal lamellar magnetism, and, below the TN of ilmenite it adopts a consistent negative orientation, giving rise to unimodal negative exchange bias of >500 mT. The results presented here cover the chemical and magnetic properties, Mossbauer results and transmission electron microscopy of the titanohematite and ilmenite lamellae. Initial magnetic experiments indicated the shifts found in the exchange-bias experiments were directly related to the orientation of the sample to the applied field and the initial state of the NRM. In most samples with these unusual magnetic properties, ilmenite lamellae could not be seen in an optical or a scanning electron microscope. However magnetic experiments gave proof of the presence of ilmenite, later confirmed by Mössbauer spectroscopy. Several attempts were made to identify ilmenite in TEM studies, finally successful in showing ilmenite lamellae parallel to (001) of hematite with thicknesses ˜1.2 to 1.7 nm and aspect ratios 7-13. Here we compare new TEM images and the magnetic

  17. Foreign trade likely to exceed US$1,600 billion this year%今年中国外贸总额可能超过16000亿美元

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Import and export of commodities will continue to grow rapidly this year, according to a forecast made by the Report on China's Foreign Trade (Spring 2006)published by the Ministry of Commerce at the recent Guangzhou Import and Export Commodities Fair.The report forecast that China's total import and export will exceed US($)1,600 billion this year, and the growth will be more than 15%.

  18. Demand for new aeroplanes in next 20 years Worth US $144 billion%未来20年中国需要飞机总值 1440亿美元

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ The 2001 Estimate of the Chinaese Market released byBoeing Company of the United States predicted that in thenext 20 years, starting this year, China′s need for civilaeroplanes would be 1,764 worth US 144 billion. By theyear 2020 China′s airlines will have more than 2, 200 aero-planes and become one of fhe largest civil aviation markets,second only to the US.

  19. Factors influencing Internet usage in older adults (65 years and above) living in rural and urban Sweden.

    Science.gov (United States)

    Berner, Jessica; Rennemark, Mikael; Jogréus, Claes; Anderberg, Peter; Sköldunger, Anders; Wahlberg, Maria; Elmståhl, Sölve; Berglund, Johan

    2015-09-01

    Older adults living in rural and urban areas have shown to distinguish themselves in technology adoption; a clearer profile of their Internet use is important in order to provide better technological and health-care solutions. Older adults' Internet use was investigated across large to midsize cities and rural Sweden. The sample consisted of 7181 older adults ranging from 59 to 100 years old. Internet use was investigated with age, education, gender, household economy, cognition, living alone/or with someone and rural/urban living. Logistic regression was used. Those living in rural areas used the Internet less than their urban counterparts. Being younger and higher educated influenced Internet use; for older urban adults, these factors as well as living with someone and having good cognitive functioning were influential. Solutions are needed to avoid the exclusion of some older adults by a society that is today being shaped by the Internet. PMID:24567416

  20. Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years and older.

    Science.gov (United States)

    Dewar, Sandra; Eliashiv, Dawn; Walshaw, Patricia D; Engel, Jerome; Fried, Itzhak; Moseley, Brian D

    2016-04-01

    OBJECT Despite its potential to offer seizure freedom, resective epilepsy surgery (RES) is seldom performed in patients 60 years of age or older. Demonstrating successful outcomes including an improved quality of life may raise awareness about the advantages of referring this underrepresented population for specialized evaluation. Accordingly, the authors investigated outcomes and life fulfillment in patients with an age ≥ 60 years who had undergone RES. METHODS All patients who, at the age of 60 years or older, had undergone RES for medically refractory focal onset seizures at the authors' center were evaluated. A modified Liverpool Life Fulfillment (LLF) tool was administered postoperatively (maximum score 32). Seizure outcomes were classified according to the Engel classification system. RESULTS Twelve patients underwent RES. The majority of patients (9 [75%] of 12) had at least 1 medical comorbidity in addition to seizures. The mean follow-up was 3.1 ± 2.1 years. At the time of the final follow-up, 11 (91.7%) of 12 patients were documented as having a good postsurgical outcome (Engel Class I-II). Half (6 of 12 patients) were completely seizure free (Engel Class IA). Liverpool Life Fulfillment (LLF) data were available for 11 patients. Following surgery, the mean LLF score was 26.7 ± 6. Eight patients (72.7%) noted excellent satisfaction with their RES, with 5 (45.5%) noting postoperative improvements in overall health. CONCLUSIONS Resective epilepsy surgery is safe and effective in patients with an age ≥ 60 years. Over 90% had a good surgical outcome, with 50% becoming completely seizure free despite 1 or more medical comorbidities in the majority. The study data indicated that an advancing age should not negatively influence consideration for RES. PMID:26381254

  1. Factors affecting dental utilization of elders aged 75 years or older.

    Science.gov (United States)

    Wilson, A A; Branch, L G

    1986-11-01

    Data collected from 496 elders aged 75 years or older participating in the Massachusetts Health Care Panel Study were analyzed by means of multiple regression to determine the principal predictors of perceived need for care and of dental users. The relationship between perceived need and use of services also was examined. The significant variables influencing perceived need in elders were poorer self-perceived oral health, having some teeth, and reporting a dental visit within two years. Dental users were best predicted by dentate status, a history of alcohol consumption, and perceived need for care. Although the variables of perceived need and being a user each influenced the other, both were more influenced by a common significant predictor variable, dentate status. PMID:3464632

  2. Outcomes and Tolerability of Chemoradiation Therapy for Pancreatic Cancer Patients Aged 75 Years or Older

    International Nuclear Information System (INIS)

    Purpose: To review the outcomes and tolerability of full-dose chemoradiation in elderly patients aged 75 years or older with localized pancreatic cancer. Methods and Materials: We retrospectively reviewed patients aged 75 years or older with nonmetastatic pancreatic cancer treated with chemoradiation therapy at two institutions from 2002 to 2007. Patients were analyzed for treatment toxicity, local recurrences, distant metastases, and survival. Results: A total of 42 patients with a median age of 78 years (range, 75-90 years) who received chemoradiation therapy for pancreatic cancer were identified. Of the patients, 24 had locally advanced disease treated with definitive chemoradiation, and 18 had disease treated with surgery and chemoradiation. Before chemoradiotherapy, the mean Eastern Cooperative Oncology Group performance status was 1.0 ± 0.8, and the mean 6-month weight loss was 5.3 ± 3.8 kg. The mean radiation dose delivered was 48.1 ± 9.2 Gy. All patients received fluoropyrimidine-based chemotherapy concurrently with radiotherapy. In all, 8 patients (19%) were hospitalized, 7 (17%) had an emergency room visit, 15 (36%) required a radiation treatment break, 3 (7%) required a chemotherapy break, 9 (21%) did not complete therapy, and 22 (49%) had at least one of these adverse events. The most common toxicities were nausea, pain, and failure to thrive. Median overall survival was 8.6 months (95% confidence interval, 7.2-13.1) in patients who received definitive chemoradiation therapy and 20.6 months (95% confidence interval, 9.5-∞) in patients who underwent resection and chemoradiation therapy. Conclusions: In this dataset of very elderly patients with pancreatic cancer and good Eastern Cooperative Oncology Group performance status, outcomes after chemoradiotherapy were similar to those among historic controls for patients with locally advanced and resected pancreatic cancer, although many patients experienced substantial treatment-related toxicity.

  3. Profile and outcome of neuroblastoma with convertional chemotherapy in children older than one year: a 15-years experience.

    Science.gov (United States)

    Bansal, Deepak; Marwaha, R K; Trehan, Amita; Rao, K L N; Gupta, Vishal

    2008-02-01

    The clinical profile and outcome of neuroblastoma in 103 children, older than one-year is presented. 74 had Stage IV, 27 Stage III and one patient each had Stage I or II disease. Treatment included chemotherapy followed by surgical resection/debulking. Radiotherapy was administered to those with residual tumor. Chemotherapy consisted of OPEC (vincristine, cyclophosphamide, cisplatin and etoposide). The caretakers of 54 (52.4%) children either did not opt for or defaulted therapy, whilst 3 patients died before chemotherapy could be initiated. Of the remaining 46 patients, the tumor progressed during therapy in 19 (41.3%). Relapse of disease was documented in 22 (47.8%) cases. Merely 4 (8.7%) children are disease free for a period of 16.5+/-6.7 months. Majority of children presented with advanced disease and the outcome was dismal with conventional non-myloablative chemotherapy. PMID:18310793

  4. Three-Year Follow-up of Conservative Treatments of Shoulder Osteoarthritis in Older Patients.

    Science.gov (United States)

    Guo, Jiong Jiong; Wu, Kailun; Guan, Huaqing; Zhang, Lei; Ji, Cheng; Yang, Huilin; Tang, Tiansi

    2016-07-01

    Little is known about the mid-term results of nonsurgical treatment for shoulder osteoarthritis (OA), especially in a Chinese population. This study sought to determine the efficacy of nonsurgical management in older patients with shoulder OA. A total of 129 conservatively treated unilateral shoulder OA patients who were older than 65 years were evaluated prospectively at the initial office visit and then subsequently at 3, 6, 12, 18, 24, and 36 months later. During the 36-month follow-up period, all patients could receive conventional therapy, such as nonsteroidal anti-inflammatory medication, corticosteroid injection, sodium hyaluronate, and education, at the discretion of treating physicians. Some patients received physiotherapy, rehabilitation training, and a shoulder strap to improve the range of motion and muscular strength training from a physical therapist. Parameters measured included comparative effectiveness of each therapeutic method, visual analog scale (VAS), Simple Shoulder Test (SST), and Short Form (36) Health Survey (SF-36) scores. At 3-year follow-up, most patients had a significant increase from their pretreatment values in pain, self-assessed shoulder function, mental health, and 5 of 8 SF-36 domains. The study showed a decline in SST and VAS at 6 and 12 months after an initial ascent at 3 months, and then it was rescued and continued at 3-year follow-up. Combined therapy could improve symptoms significantly. This study suggests that a conservative approach may be more appropriate and can produce satisfactory mid-term outcomes in selected cases. The findings of this study suggest that conservative treatments should be extended for longer than 12 months before the decision regarding shoulder arthroplasty is made. [Orthopedics. 2016; 39(4):e634-e641.]. PMID:27286050

  5. Sarcopenia, but not sarcopenic obesity, predicts mortality for older old men: A 3-year prospective cohort study

    OpenAIRE

    Li-Kuo Liu, MD; Liang-Yu Chen, MD; Kuo-Ping Yeh, MD; Ming-Hsien Lin, MD; An-Chun Hwang, MD; Li-Ning Peng, MD; Liang-Kung Chen, MD, PhD

    2014-01-01

    Background: The prognostic significance of sarcopenia and sarcopenic obesity (SO) among older people remains controversial. The main aim of this study was to evaluate the mortality risk of sarcopenia and SO among men aged 75 years and older in Taiwan. Methods: This prospective cohort study recruited all residents of the Banciao Veterans Home, a veterans retirement community in Taipei City in northern Taiwan. For all study participants, the demographic profile, comorbid medical conditions, ...

  6. [The 50-year-old women or older: preventive actions to the HIV infection].

    Science.gov (United States)

    Rodrigues, Daniela Angelo de Lima; Praça, Neide de Souza

    2010-06-01

    The present study is a qualitative research which aimed to verify the adoption of preventive measures on the transmission of HIV in 50-year-old women or older, who lived in poor communities and were assisted by the Family Health Program in São Paulo, Brazil. Medical Anthropology has been adopted as a theoretical reference, as well as the Discourse of the Collective Individual for data analysis. Thirteen women were interviewed and three discourses were presented: prevention appreciation, invisibility of HIV/AIDS and the rejection of the use of condom. The analysis showed that the group did not realize the risk of contamination through sexual intercourse due to their trust in the partner's loyalty. The casual use of condoms was taken into consideration just out of curiosity. The preventive actions adopted need more scientific support. The results point out the necessity of planning and implementing interventions which are culturally based and directed to the studied segment. PMID:21500513

  7. Predictors of dependence among people older than 65 years: a systematic review

    Directory of Open Access Journals (Sweden)

    Gloriannys Baez

    2013-12-01

    Full Text Available This paper systematically reviews the tools used to study dependence and disability in individuals older than 65 years and the predictors employed in analysing the trajectory of functional decline in this population. The search was conducted using the Scopus database and 23 out of the 734 available research abstracts were selected using ad hoc categories. The instruments and predictors were coded according to display format, domain of activity, and outcome measurement (disability or dependence. The results show limitations in the way the measures are conceptualized and selected, due to the lack of a standardized definition of the concepts and the inappropriate interpretation of test scores. Future research should explicitly distinguish dependence from disability, and correctly validate existing instruments or construct new ones using modern psychometric models.

  8. The relation between brain activity during memory tasks and years of education in young and older adults.

    Science.gov (United States)

    Springer, Mellanie V; McIntosh, Anthony R; Winocur, Gordon; Grady, Cheryl L

    2005-03-01

    Higher education is associated with less age-related decline in cognitive function, but the mechanism of this protective effect is unknown. The authors examined the effect of age on the relation between education and brain activity by correlating years of education with activity measured using functional MRI during memory tasks in young and older adults. In young adults, education was negatively correlated with frontal activity, whereas in older adults, education was positively correlated with frontal activity. Medial temporal activity was associated with more education in young adults but less education in older adults. This suggests that the frontal cortex is engaged by older adults, particularly by the highly educated, as an alternative network that may be engaged to aid cognitive function. PMID:15769202

  9. The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

    Science.gov (United States)

    Izaks, Gerbrand J.; Gansevoort, Ron T.; van der Knaap, Aafke M.; Navis, Gerjan; Dullaart, Robin P. F.; Slaets, Joris P. J.

    2011-01-01

    APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers. PMID:22110642

  10. Lipids and All-Cause Mortality among Older Adults: A 12-Year Follow-Up Study

    Directory of Open Access Journals (Sweden)

    Marcos Aparecido Sarria Cabrera

    2012-01-01

    Full Text Available This is a 12-year follow-up cohort study with 800 people (60–85 years old. The association between lipid disorders and mortality was analysed by Cox proportional hazard adjusted model. All-cause mortality was considered the dependent variable, and lipid disorders as independent variables: total cholesterol (TC >200 and 100 and 130, and triglycerides (TG >50. An initial analysis of all subjects was performed and a second was carried out after having excluded individuals with a body mass index (BMI <20 kg/m2 or mortality in ≤2 years. The mortality showed a positive association with low TC and a negative association with high TC and high LDL-c. After the exclusion of underweight and premature mortality, there was a positive association only with TC <170 mg/dl (HR = 1.36, CI95%: 1.02–1.82. The data did not show a higher risk with high levels of TC, LDL-c, and TG. However, they showed higher mortality among older adults with low TC.

  11. Tolerability of Combined Modality Therapy for Rectal Cancer in Elderly Patients Aged 75 Years and Older

    International Nuclear Information System (INIS)

    Purpose: To determine the rate of treatment deviations during combined modality therapy for rectal cancer in elderly patients aged 75 years and older. Methods and Materials: We reviewed the records of consecutively treated patients with rectal cancer aged 75 years and older treated with combined modality therapy at Massachusetts General Hospital and Brigham and Women’s Hospital from 2002 to 2007. The primary endpoint was the rate of treatment deviation, defined as a treatment break, dose reduction, early discontinuation of therapy, or hospitalization during combined modality therapy. Patient comorbidity was rated using the validated Adult Comorbidity Evaluation 27 Test (ACE-27) comorbidity index. Fisher’s exact test and the Mantel–Haenszel trend test were used to identify predictors of treatment tolerability. Results: Thirty-six eligible patients had a median age of 79.0 years (range, 75–87 years); 53% (19/36) had no or mild comorbidity and 47% (17/36) had moderate or severe comorbidity. In all, 58% of patients (21/36) were treated with preoperative chemoradiotherapy (CRT) and 33% (12/36) with postoperative CRT. Although 92% patients (33/36) completed the planned radiotherapy (RT) dose, 25% (9/36) required an RT-treatment break, 11% (4/36) were hospitalized, and 33% (12/36) had a dose reduction, break, or discontinuation of concurrent chemotherapy. In all, 39% of patients (14/36) completed ≥4 months of adjuvant chemotherapy, and 17% (6/36) completed therapy without a treatment deviation. More patients with no to mild comorbidity completed treatment than did patients with moderate to severe comorbidity (21% vs. 12%, p = 0.66). The rate of deviation did not differ between patients who had preoperative or postoperative CRT (19% vs. 17%, p = 1.0). Conclusions: The majority of elderly patients with rectal cancer in this series required early termination of treatment, treatment interruptions, or dose reductions. These data suggest that further intensification

  12. Recommendations for Serogroup B Meningococcal Vaccine for Persons 10 Years and Older.

    Science.gov (United States)

    2016-09-01

    This policy statement provides recommendations for the prevention of serogroup B meningococcal disease through the use of 2 newly licensed serogroup B meningococcal vaccines: MenB-FHbp (Trumenba; Wyeth Pharmaceuticals, a subsidiary of Pfizer, Philadelphia, PA) and MenB-4C (Bexsero; Novartis Vaccines, Siena, Italy). Both vaccines are approved for use in persons 10 through 25 years of age. MenB-FHbp is licensed as a 2- or 3-dose series, and MenB-4C is licensed as a 2-dose series for all groups. Either vaccine is recommended for routine use in persons 10 years and older who are at increased risk of serogroup B meningococcal disease (category A recommendation). Persons at increased risk of meningococcal serogroup B disease include the following: (1) persons with persistent complement component diseases, including inherited or chronic deficiencies in C3, C5-C9, properdin, factor D, or factor H or persons receiving eculizumab (Soliris; Alexion Pharmaceuticals, Cheshire, CT), a monoclonal antibody that acts as a terminal complement inhibitor by binding C5 and inhibiting cleavage of C5 to C5A; (2) persons with anatomic or functional asplenia, including sickle cell disease; and (3) healthy persons at increased risk because of a serogroup B meningococcal disease outbreak. Both serogroup B meningococcal vaccines have been shown to be safe and immunogenic and are licensed by the US Food and Drug Administration for individuals between the ages of 10 and 25 years. On the basis of epidemiologic and antibody persistence data, the American Academy of Pediatrics agrees with the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention that either vaccine may be administered to healthy adolescents and young adults 16 through 23 years of age (preferred ages are 16 through 18 years) to provide short-term protection against most strains of serogroup B meningococcal disease (category B recommendation). PMID:27573083

  13. Vulnerabilities in Older Patients when Cancer Treatment is Initiated: Does a Cognitive Impairment Impact the Two-Year Survival?

    Science.gov (United States)

    Borghgraef, Cindy; Etienne, Anne-Marie; Merckaert, Isabelle; Paesmans, Marianne; Reynaert, Christine; Roos, Myriam; Slachmuylder, Jean-Louis; Vandenbossche, Sandrine; Bron, Dominique; Razavi, Darius

    2016-01-01

    Introduction Dementia is a known predictor of shorter survival times in older cancer patients. However, no empirical evidence is available to determine how much a cognitive impairment shortens survival in older patients when cancer treatment is initiated. Purpose To longitudinally investigate how much a cognitive impairment detected at the initiation of cancer treatment influences survival of older patients during a two-year follow-up duration and to compare the predictive value of a cognitive impairment on patients survival with the predictive value of other vulnerabilities associated with older age. Methods Three hundred and fifty-seven consecutive patients (≥65 years old) admitted for breast, prostate, or colorectal cancer surgeries were prospectively recruited. A cognitive impairment was assessed with the Montreal Cognitive Assessment (MoCA<26). Socio-demographic, disease-related, and geriatric vulnerabilities were assessed using validated tools. Univariate and subsequent multivariate Cox proportional hazards models stratified for diagnosis (breast/prostate cancer versus colorectal cancer) and disease status (metastatic versus non-metastatic) were used. Results A cognitive impairment was detected in 46% (n = 163) of patients. Survival was significantly influenced by a cognitive impairment (HR = 6.13; 95% confidence interval [CI] = 2.07–18.09; p = 0.001), a loss in instrumental autonomy (IADL ≤7) (HR = 3.06; 95% CI = 1.31–7.11; p = 0.009) and fatigue (Mob-T<5) (HR = 5.98; 95% CI = 2.47–14.44; p <0.001). Conclusions During the two years following cancer treatment initiation, older patients with a cognitive impairment were up to six times more likely to die than patients without. Older patients should be screened for cognitive impairments at cancer treatment initiation to enable interventions to reduce morbidity and mortality. Further studies should address processes underlying the relationship between cognitive impairments and an increased risk of dying

  14. Book review: 10 billion

    OpenAIRE

    Saffin, Kate

    2013-01-01

    10 Billion aims to take a dramatic look at the challenges we face today, from over-population to energy wars, to melting ice caps to civil conflict, presented in an eye-catching infographic style. Stephen Emmott has attempted to obtain reach and for all the criticism of his method and writing, it is not as though he is pretending that this would make it in to a journal, an article for which he is more than capable of writing. Science communication is never easy, writes Kate Saffin, and if Emm...

  15. Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population.

    Science.gov (United States)

    McDonald, Cameron Keith; Ankarfeldt, Mikkel Z; Capra, Sandra; Bauer, Judy; Raymond, Kyle; Heitmann, Berit Lilienthal

    2016-05-01

    Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35-65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results. PMID:26979049

  16. Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment

    DEFF Research Database (Denmark)

    Emborg, Hanne Dorthe; Krause, Tyra Grove; Nielsen, Lene;

    2016-01-01

    In Denmark, both influenza A(H1N1)pdm09 and influenza B co-circulated in the 2015/16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. The adjusted VE against influenza A(H1N1)pdm09 wa...

  17. Selective fine needle aspiration of parotid masses. FNA should be performed in all patients older than 60 years.

    LENUS (Irish Health Repository)

    Kieran, S M

    2012-02-01

    OBJECTIVES: The exact role of fine needle aspiration in the pre-operative assessment of patients presenting with parotid masses is controversial. Some surgeons propose that fine needle aspiration be performed only selectively in those patients with likely malignant disease, whilst others recommend it for all patients presenting with such a mass. Intuitively, one would expect older patients to be more likely to suffer from primary malignant parotid tumours and secondary deposits of malignant skin tumours. Therefore, we hypothesised that older patients with a parotid mass should undergo fine needle aspiration regardless of their medical history. DESIGN: We retrospectively reviewed 197 consecutive parotidectomies to test this hypothesis. RESULTS: One hundred and twenty-one patients (61.4 per cent) were diagnosed with benign disease, whilst 76 (38.6 per cent) were diagnosed with malignant disease. Eighty-three per cent of patients aged 60 years or younger had benign disease, as opposed to 35.6 per cent of patients aged more than 60 years. Malignant disease occurred more commonly in patients older than 60 years (odds ratio 8.962, 95 per cent confidence interval 4.607-17.434). CONCLUSION: In patients with a parotid mass, fine needle aspiration should be performed on all those aged 60 years or older.

  18. Regional and Gender Differences in Years with and without Mobility Limitation in the Older Population of Thailand

    OpenAIRE

    Apinonkul, Benjawan; Soonthorndhada, Kusol; Vapattanawong, Patama; Jagger, Carol; Aekplakorn, Wichai

    2016-01-01

    Objectives To examine gender and regional differences in health expectancies based on the measure of mobility. Methods Health expectancies by gender and region were computed by Sullivan’s method from the fourth Thai National Health Examination Survey (2009). A total of 9,210 older persons aged 60 years and older were included. Mobility limitation was defined as self-reporting of ability to perform only with assistances/aids at least one of: walking at least 400 metres; or going up or down a f...

  19. Depression Interventions among Racial and Ethnic Minority Older Adults: A Systematic Review across 20 Years

    OpenAIRE

    Fuentes, Dahlia; Aranda, María P.

    2012-01-01

    While there is strong evidence in support of geriatric depression treatments, much less is available with regard to older U.S. racial and ethnic minorities. The objectives of this review are to identify and appraise depression treatment studies tested with samples of U.S. racial and ethnic minority older adults. We include an appraisal of sociocultural adaptations made to the depression treatments in studies meeting our final criteria. Systematic search methods were utilized to identify resea...

  20. Body Image, self-esteem, and clothing of men and women aged 55 years and older

    OpenAIRE

    Hwang, Jinsook

    1993-01-01

    Although there are many studies regarding body image of younger people, there have been few studies on that of older people. Since today's culture considers the young, thin body image ideal, it is important to investigate body image of older people and the relationships between their body image, self esteem, and clothing behavior. The purpose of this study was to determine the relationships between 1) body-cathexis and self-esteem, 2) body-cathexis and clothing behavio...

  1. Arthroscopic Findings After Traumatic Shoulder Instability in Patients Older Than 35 Years

    OpenAIRE

    Robinson, Elisabeth C.; Thangamani, Vijay B.; Kuhn, Michael A.; Ross, Glen

    2015-01-01

    Background: Shoulder instability in the older patient traditionally has received less attention in the literature than in the younger patient population. However, when traumatic dislocation does occur, these patients often still have frequent pain, disability, and even continued instability. Purpose: To characterize the pathoanatomy of traumatic anterior shoulder instability in the older patient population and to discuss the correlating symptoms that ultimately led to operative treatment. Stu...

  2. One-year follow-up of non-institutionalized dependent older adults: mortality, hospitalization, and mobility.

    Science.gov (United States)

    Sarria Cabrera, Marcos Aparecido; Gomes Dellaroza, Mara Solange; Trelha, Celita Salmaso; Cecilio, Celso Henrique; Souza, Sara Ellias de

    2012-09-01

    Non-institutionalized dependent older adults present high morbidity and mortality, demand care from their families, and consume primary health care resources. To expand knowledge about this group, we conducted a population-based one-year prospective cohort study of 130 non-institutionalized dependent older persons (age 60 and older), stratified according to baseline mobility: independent walking (group A), use of walking aids (group B), and bedridden or confined to a wheelchair (group C). The outcomes analysed were death, hospitalization, and mobility disability. Total mortality was 8.5 per cent (p = .05). Overall hospitalization rate was 34.6 per cent; the main causes were stroke and pneumonia. After one year, there was a decline in the proportion of subjects classified as independent walking (57% vs. 43%; p = .03). We conclude that there was a high rate of mortality and hospitalization in this group of dependent older people, and an increase in disability after a one-year follow-up. PMID:22805052

  3. Average daily nitrate and nitrite intake in the Belgian population older than 15 years.

    Science.gov (United States)

    Temme, E H M; Vandevijvere, S; Vinkx, C; Huybrechts, I; Goeyens, L; Van Oyen, H

    2011-09-01

    The aim of this study was to assess the dietary intake of nitrate and nitrite in Belgium. The nitrate content of processed vegetables, cheeses and meat products was analysed. These data were completed by data from non-targeted official control and from the literature. In addition, the nitrite content of meat products was measured. Concentration data for nitrate and nitrite were linked to food consumption data of the Belgian Food Consumption Survey. This study included 3245 respondents, aged 15 years and older. Food intakes were estimated by a repeated 24-h recall using EPIC-SOFT. Only respondents with two completed 24-h recalls (n=3083) were included in the analysis. For the intake assessment, average concentration data and individual consumption data were combined. Usual intake of nitrate/nitrite was calculated using the Nusser method. The mean usual daily intake of nitrate was 1.38 mg kg(-1) bodyweight (bw) day(-1) and the usual daily intake at the 97.5 percentile was 2.76 mg kg(-1) bw day(-1). Exposure of the Belgian population to nitrate at a mean intake corresponded to 38% of the ADI (while 76% at the 97.5 percentile). For the average consumer, half of the intake was derived from vegetables (especially lettuce) and 20% from water and water-based drinks. The average daily intake of nitrate and nitrite from cheese and meat products was low (0.2% and 6% of the ADI at average intake, respectively). Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate. Whether this is beneficial or harmful must be further assessed. PMID:21728895

  4. Adding Years to Life and Life to Years - A Health Promotion Strategy for Older People in Ireland

    OpenAIRE

    Department of Health

    1998-01-01

    This Health Strategy points to the need for promoting healthy ageing in conjunction with the then National Council for Elderly – a goal which was re-iterated in the 1995 Health Promotion Strategy, in which older people were identified as a priority  population group with particular health promotion needs  

  5. Personality and Risk for Alzheimer’s Disease in Adults 72 Years of Age and Older: A Six-Year Follow-Up

    OpenAIRE

    Duberstein, Paul R.; Chapman, Benjamin P.; Tindle, Hilary A.; Sink, Kaycee M; Bamonti, Patricia; Robbins, John; Jerant, Anthony F.; Franks, Peter

    2011-01-01

    We conducted secondary analyses to determine the relationship between longstanding personality traits and risk for Alzheimer’s disease (AD) among 767 participants 72 years of age or older who were followed for more than 6 years. Personality was assessed with the NEO-FFI. We hypothesized that elevated Neuroticism, lower Openness, and lower Conscientiousness would be independently associated with risk of AD. Hypotheses were supported. The finding that AD risk is associated with elevated Neuroti...

  6. Regional and Gender Differences in Years with and without Mobility Limitation in the Older Population of Thailand

    Science.gov (United States)

    Apinonkul, Benjawan; Soonthorndhada, Kusol; Vapattanawong, Patama; Jagger, Carol; Aekplakorn, Wichai

    2016-01-01

    Objectives To examine gender and regional differences in health expectancies based on the measure of mobility. Methods Health expectancies by gender and region were computed by Sullivan’s method from the fourth Thai National Health Examination Survey (2009). A total of 9,210 older persons aged 60 years and older were included. Mobility limitation was defined as self-reporting of ability to perform only with assistances/aids at least one of: walking at least 400 metres; or going up or down a flight of 10 stairs. Severe limitation was defined as complete inability to do at least one of these two functions, even with assistances or aids. Results At age 60, females compared to males, spent significantly fewer years without mobility limitation (male-female = 3.2 years) and more years with any limitation (female-male = 6.7 years) and with severe limitation (female-male = 3.2 years). For both genders, years lived with severe limitation were remarkably constant across age. Significant regional inequalities in years lived without and with limitation were evident, with a consistent pattern by gender in years free of mobility limitation (Central ranked the best and the North East ranked the worst). Finally, both males and females in the South had the longest life expectancy and the most years of life with severe mobility limitation. Conclusion This study identifies inequalities in years without and with mobility limitations with important policy implication. PMID:27138811

  7. Regional and Gender Differences in Years with and without Mobility Limitation in the Older Population of Thailand.

    Directory of Open Access Journals (Sweden)

    Benjawan Apinonkul

    Full Text Available To examine gender and regional differences in health expectancies based on the measure of mobility.Health expectancies by gender and region were computed by Sullivan's method from the fourth Thai National Health Examination Survey (2009. A total of 9,210 older persons aged 60 years and older were included. Mobility limitation was defined as self-reporting of ability to perform only with assistances/aids at least one of: walking at least 400 metres; or going up or down a flight of 10 stairs. Severe limitation was defined as complete inability to do at least one of these two functions, even with assistances or aids.At age 60, females compared to males, spent significantly fewer years without mobility limitation (male-female = 3.2 years and more years with any limitation (female-male = 6.7 years and with severe limitation (female-male = 3.2 years. For both genders, years lived with severe limitation were remarkably constant across age. Significant regional inequalities in years lived without and with limitation were evident, with a consistent pattern by gender in years free of mobility limitation (Central ranked the best and the North East ranked the worst. Finally, both males and females in the South had the longest life expectancy and the most years of life with severe mobility limitation.This study identifies inequalities in years without and with mobility limitations with important policy implication.

  8. 16 CFR Figure 4 to Part 1203 - Location of Test Lines for Helmets Intended for Persons Five (5) Years of Age and Older

    Science.gov (United States)

    2010-01-01

    ... for Persons Five (5) Years of Age and Older 4 Figure 4 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt...) Years of Age and Older ER10MR98.004...

  9. Life styles related to coronary artery disease in Saudi Males older than 12 years of age

    International Nuclear Information System (INIS)

    The present study highlighted life styles related to coronary artery disease risk factors among patients attending a primary care clinic at King Khalid University Hospital, in Riyadh, Saudi Arabia. We conducted a cross-sectional study at a primary care clinic at King Khalid University Hospital, Riyadh, Saudi Arabia, during the period from 18/4/2006 to 13/6/2006. All adult male patients older than 12 years of age who attended one consultant primary care clinic were included in the study. All patients were interviewed by one consultant in family medicine during the study period. The patients were asked about dietary habits, physical activity and type of exercise, and smoking habits. Weight and height was taken for all patients by the nurse in the clinic and body mass index (BMI) were calculated for all patients. The total number of participants was 246 patients. The data were analyzed using the Statistical Package of Social Science (SPSS) version 11.5. A p value of less than 0.05 was considered statistically significant. Of the 246 male adult patients, 45.4% always consumed vegetables and fruits in their diet, 21.5% exercised on a daily basis, 51.2% exercised sometimes and 26% did not exercise at all. The type of exercise practiced by active participants was walking (76.5%) and sports (22.9%). Sports included football, basketball, swimming and other sports club activity. Only 20.7% of the participants had an ideal body weight (BMI=30). 8.9% of the participants were current smokers. Overweight and obesity is a common health problem among male adult patients attending a primary care setting. Improved dietary habits (consumption of vegetables and fruits and minimization of fat and suits) encouraging exercise and walking and helping current smokers to quit smoking are essential steps towards improving life styles in the community. It is an important health plan priority to concentrate on improving life styles in the Saudi community, to prevent cardiovascular risk factors

  10. The harmonic ratio of trunk acceleration predicts falling among older people: results of a 1-year prospective study

    OpenAIRE

    Doi Takehiko; Hirata Soichiro; Ono Rei; Tsutsumimoto Kota; Misu Shogo; Ando Hiroshi

    2013-01-01

    Abstract Background Gait variables derived from trunk accelerometry may predict the risk of falls; however, their associations with falls are not fully understood. The purpose of the study was to determine which gait variables derived from upper and lower trunk accelerometry are associated with the incidence of falls, and to compare the discriminative ability of gait variables and physical performance. Methods This study was a 1-year prospective study. Older people (n = 73) walked normally wh...

  11. Prospective Associations Between Leisure-Time Physical Activity and Cognitive Performance Among Older Adults Across an 11-Year Period

    OpenAIRE

    Ku, Po-Wen; Stevinson, Clare; Chen, Li-Jung

    2012-01-01

    Background Few studies have explored the relations between naturally occurring changes in physical activity and cognitive performance in later life. This study examined prospective associations between changes in physical activity and cognitive performance in a population-based sample of Taiwanese older adults during an 11-year period. Methods Analyses were based on nationally representative data from the Taiwan Health and Living Status of the Elderly Survey collected in 1996, 1999, 2003, and...

  12. FY97 nuclear-related budgets total 493 billion yen (4.4 billion dollars)

    International Nuclear Information System (INIS)

    On September 13, the Atomic Energy Commission of Japan announced the estimated nuclear-related budget requests for FY1997 (April, 1997 - Mach, 1998), giving the breakdowns for eight ministries and agencies. The total amount requested by the government bodies was 493.3 billion yen, 0.8% increase as compared with FY96. this figure includes the budget requests of the Science and Technology Agency (STA), the Ministry of International Trade and Industry (MITI), the Ministry of Foreign Affairs, the Ministry of Transport, the Ministry of Agriculture, Forestry and Fisheries, the Okinawa Development Agency, and the Ministry of Home Affairs, but excludes the budget request made by the Ministry of Education. The budget requests of STA and MITI are 360 billion yen and 126 billion yen, respectively. On August 29, STA released its estimated FY97 budget request. The nuclear-related 360.4 billion yen is 0.9% more than that in year before. Of this sum, 199.9 billion yen is in the general account, and 160.6 billion yen is in the special account for power source development. The details of the nuclear-related amounts are explained. On August 26, MITI released its estimated budget request for FY97, and of the nuclear-related 125.7 billion yen (0.1% increase from FY96), 200 million yen is in the general account, and 98.9 billion yen and 26.6 billion yen are in the special accounts for power resource development and power source diversification, respectively. (K.I.)

  13. Increasing Independence through Technology: The Views of Older Consumers with Disabilities and Their Caregivers. Consumer Needs Assessment Project Year 3: Results of the Third Year of a Five Year Study.

    Science.gov (United States)

    Ward, Carolyn

    The goal of this third year of an ongoing 5-year study was to identify and evaluate the diverse technology and product needs of persons with functional limitations, from users' perspectives. This qualitative research study involved 14 focus groups representing 4 different categories of people; those included persons 50 years and older with sensory…

  14. Probing the Big Bang at the Relativistic Heavy Ion Collider (RHIC) (or Probing the Big Bang 13.7 billion years later)

    International Nuclear Information System (INIS)

    The Relativistic Heavy Ion Collider (RHIC) at the Brookhaven National Laboratory in the USA is a variable energy proton-proton and ion-ion collider that is the first accelerator capable of colliding heavy ions. RHIC was designed to do experiments that provide important information about the Standard Model of particle physics, Quantum Chromodynamics (QCD). QCD predicts that in the early part of the Universe just after the Big Bang the world consisted of a Quark Gluon Plasma, a weakly interacting collection of quarks and gluons. At RHIC we can recreate the conditions of the early Universe by colliding heavy ions at 200 GeV. This paper will give a general overview of the physics motivation for studying the QGP, how our experiments are designed to study the QGP, what we have learned over the last 9 years, and what the future holds.

  15. Kicking Back Cognitive Ageing: Leg Power Predicts Cognitive Ageing after Ten Years in Older Female Twins

    OpenAIRE

    Steves, Claire J; Mehta, Mitul M.; Jackson, Stephen H D; Spector, Tim D.

    2015-01-01

    Background: Many observational studies have shown a protective effect of physical activity on cognitive ageing, but interventional studies have been less convincing. This may be due to short time scales of interventions, suboptimal interventional regimes or lack of lasting effect. Confounding through common genetic and developmental causes is also possible. Objectives: We aimed to test whether muscle fitness (measured by leg power) could predict cognitive change in a healthy older population ...

  16. 100 billion suns

    International Nuclear Information System (INIS)

    A work on the world of astrophysics primarily for lay readers. The author writes only about the discoveries he ''experienced'' during the past 25 years (before 1979). Illustrated somewhat in color plus a set of superb colar plates. Contents, abridged: The long life of stars. The life story of the sun. The life story of massive stars. The end of stars. How stars are born. Planets and their inhabitants

  17. Oxygen - A Four Billion Year History

    DEFF Research Database (Denmark)

    Canfield, Donald Eugene

    Canfield--one of the world's leading authorities on geochemistry, earth history, and the early oceans--covers this vast history, emphasizing its relationship to the evolution of life and the evolving chemistry of the Earth. With an accessible and colorful first-person narrative, he draws from a variety of...... fields, including geology, paleontology, geochemistry, biochemistry, animal physiology, and microbiology, to explain why our oxygenated Earth became the ideal place for life. Describing which processes, both biological and geological, act to control oxygen levels in the atmosphere, Canfield traces the...... guides readers through the various lines of scientific evidence, considers some of the wrong turns and dead ends along the way, and highlights the scientists and researchers who have made key discoveries in the field. Showing how Earth's atmosphere developed over time, Oxygen takes readers on a...

  18. Four billion people facing severe water scarcity.

    Science.gov (United States)

    Mekonnen, Mesfin M; Hoekstra, Arjen Y

    2016-02-01

    Freshwater scarcity is increasingly perceived as a global systemic risk. Previous global water scarcity assessments, measuring water scarcity annually, have underestimated experienced water scarcity by failing to capture the seasonal fluctuations in water consumption and availability. We assess blue water scarcity globally at a high spatial resolution on a monthly basis. We find that two-thirds of the global population (4.0 billion people) live under conditions of severe water scarcity at least 1 month of the year. Nearly half of those people live in India and China. Half a billion people in the world face severe water scarcity all year round. Putting caps to water consumption by river basin, increasing water-use efficiencies, and better sharing of the limited freshwater resources will be key in reducing the threat posed by water scarcity on biodiversity and human welfare. PMID:26933676

  19. Improved Race Times in Marathoners Older than 75 Years in the Last 25 Years in the World's Largest Marathons.

    Science.gov (United States)

    Ahmadyar, Baschir; Rosemann, Thomas; Rüst, Christoph Alexander; Knechtle, Beat

    2016-06-30

    Performance trends of elite marathoners are well investigated. However, performance of elderly marathoners (> 75 years) competing in the world's largest city marathons is not well-known. We examined marathon race data of 1,691 marathon finishes (i.e. 218 women and 1,473 men) competing between 1990 and 2014 in 5-year age groups 75-79, 80-84, 85-89, and 95-99 years in four races (Berlin, New York, Chicago and Boston) of the 'World Marathon Majors'. The number of female (r² = 0.50, P race times. Women and men in age group 75-79 years improved race times. In age groups 80-84 to 90-94 years, women and men were not able to reduce race times. In summary, participation increased and performance improved in female and male marathoners competing in age groups 75-79 to 95-99 years where the largest increases in participation and the largest improvements in performance were found in women and men in age group 75-79 years. PMID:27188466

  20. The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older

    DEFF Research Database (Denmark)

    McGue, Matt; Christensen, Kaare

    2002-01-01

    -sequential study of twins assessed every 2 years for up to four waves. Cognitive ability was assessed by five brief cognitive tasks: a fluency measure, forward and backward digit span, and immediate and delayed list recall. Model-fitting results indicated that although the overall level of cognitive functioning...... was highly heritable (h(2) = .76, 95% confidence interval of .68 to .82), the rate of linear change was not (h(2) = .06, 95% confidence interval of .00 to .57). These findings suggest that the search for specific genes might reasonably focus on average level of cognitive performance, whereas specific......To investigate heritable influences on overall level and rate-of-change in cognitive ability, biometric growth models were fit to cognitive data from nearly 1000 Danish twins age 70 years and older. Twins are participants in the ongoing Longitudinal Study of Aging Danish Twins, a cohort...

  1. The nonprofit sector's $100 billion opportunity.

    Science.gov (United States)

    Bradley, Bill; Jansen, Paul; Silverman, Les

    2003-05-01

    Imagine what an extra $100 billion a year could do for philanthropic and other nonprofit institutions. According to a new study, the nonprofit sector could free that amount--maybe even more--by making five changes in the way it operates. The study asked two central questions: Does the sector's money flow from its source to its ultimate use as efficiently and effectively as possible? If not, where are the big opportunities to increase social benefit? According to former senator Bill Bradley and McKinsey's Paul Jansen and Les Silverman, nonprofits could save roughly $25 billion a year by changing the way they raise funds. By distributing funds more quickly, they could put an extra $30 billion to work. Organizations could generate more than $60 billion a year by streamlining and restructuring the way in which they provide services and by reducing administrative costs. And they could free up even more money--an amount impossible to estimate--by better allocating funds among service providers. The authors admit that making those changes won't be easy. The nonprofit world, historically seen as a collection of locally focused charities, has become an enormous sector, but it lacks the managerial processes and incentives that help keep the for-profit world on track. And when the baby boomers start to retire in less than a decade, public budgets will be squeezed even more than they are today. If the nonprofit sector is to help the nation cope with the stresses ahead, it must become more efficient and challenge its traditional concepts of stewardship. PMID:12747166

  2. A billion-dollar bonanza

    International Nuclear Information System (INIS)

    In late May -- only weeks after Congress had rejected the president's economic stimulus package because it would add to the federal deficit -- the House of Representatives generously allocated an extra $1.2 billion to the Pentagon. This article discusses some of the rationalizations House members gave for the gift and describes the attempts of a bipartisan group to defeat this request for funds propounded by Pennsylvania Democrat John Murtha. This gist of the arguments for and against the $1.2 billion and the results of votes on the bill are presented

  3. Detection of oncogenic genital human papillomavirus (HPV) among HPV negative older and younger women after 7 years of follow-up

    DEFF Research Database (Denmark)

    Brogaard, Kim Agerholm; Munk, Christian; Iftner, Thomas;

    2014-01-01

    The knowledge on risk factors of being human papillomavirus (HPV)-positive among older women is sparse. The aim was to determine the frequency of oncogenic HPV appearance after 7 years among initially HPV-negative women and to examine potential risk factors that influence the occurrence of HPV...... a gynecological examination at two time points (7 years apart). Cervical samples were tested for HPV using Hybrid Capture 2 (HC2) and only women who tested HC2-negative at baseline were included. The HPV prevalence among older and younger women was 6.4% and 10.7%, respectively, and there was no "second peak......" observed among older women. Recent sexual partners were a strong determinant of HPV appearance irrespective of age. Lifetime number of sexual partners was a significant risk factor for HPV appearance among older women, even after adjustment for recent sexual behavior. In addition, menopause was associated...

  4. Treating Urge Incontinence in Older Women: A Cost-Effective Investment in Quality-Adjusted Life-Years (QALY

    Directory of Open Access Journals (Sweden)

    Victoria L. Phillips

    2015-01-01

    Full Text Available Objectives. To conduct cost-effectiveness analyses of urge incontinence treatments for older women. Methods. Decision-analytic models assessed three treatment pathways: (1 limited behavioral therapy (LBT; (2 full behavioral therapy (FBT with biofeedback; and (3 drug (DRUG, with allowances for crossover options following initial treatments. Model inputs were gathered from published data. Cost data were based on third party payer reimbursement. Outcomes were measured as the number of incontinence episodes avoided and quality-adjusted life years gained (QALYs. Results. At baseline values costs per QALY gained ranged from US$3696 to $10609. LBT was the least costly with the lowest benefit. Switching from LBT to FBT, with the greatest gain, was $415 per additional QALY. DRUG was the most expensive option. Sensitivity analyses showed that only small changes in key inputs were required for DRUG to generate greater gains than FBT. Medication costs had to fall substantially for DRUG to be cost competitive. Conclusion. All treatment strategies provide QALYs gains at a bargain price, compared to the standard of US$50,000 per QALY gained. No single treatment strategy dominated under all conditions. Clinicians should offer multiple treatment options to older women with urge incontinence.

  5. Predictive factors for ageing without the need for assistance in a population of individals older than 80 years.

    Directory of Open Access Journals (Sweden)

    Amphoux M

    2005-03-01

    Full Text Available Aims: To determine the factors associated with different health-outcomes following retirement. Method: We randomly selected a sample of 869 male and female subjects aged 60 years or older from the databases of a supplemental retirement fund and followed them from 1982 (T1 to 2002 (T5. During the study period, we recorded information concerning their social status and health five different times by using both interviews and auto-questionnaires. The subsequent statistical analysis was designed to identify the factors at T1 which could predict the evolution in their state of health between T1 and T5. Results: A total of 532 (61.2% subjects died between T1 and T5. 120 subjects were still participating in the study at T5, corresponding to 53.3% of the surviving subjects in August 2002 among those who were enrolled at T1. 66% of the males and 50.7% of the females considered that their quality of life was good. More than one subject out of two stated that he or she didn’t require any assistance to perform normal, daily activities other than routine housekeeping chores. The study identified four factors at T1 which predicted future ageing without the need for assistance: age, social status, degree of physical activity in males and the absence of any cardio-respiratory disorder in females. Conclusion: The results suggest that more than 30% of subjects older than 85 years state that they live without assistance, except for routine housekeeping chores. The study also underscores the relationship between factors which are present a few years after retirement and the health-outcome at old age.

  6. What physical performance measures predict incident cognitive decline among intact older adults? A 4.4year follow up study.

    Science.gov (United States)

    Veronese, Nicola; Stubbs, Brendon; Trevisan, Caterina; Bolzetta, Francesco; De Rui, Marina; Solmi, Marco; Sartori, Leonardo; Musacchio, Estella; Zambon, Sabina; Perissinotto, Egle; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe

    2016-08-01

    Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a higher incidence of CI/CD during a 4-year follow-up among a cohort of elderly individuals. From 3099 older community-dwelling individuals initially enrolled in the Progetto Veneto Anziani (PRO.V.A.) study, 1249 participants without CI at the baseline were included (mean age 72.2years, 59.5% females). Physical performance measures included the Short Physical Performance Battery (SPPB), 4m gait speed, chair stands time, leg extension and flexion, handgrip strength, and 6-Minute Walking Test (6MWT), categorized in gender-specific tertiles. CI was defined as a Mini-Mental State Examination (MMSE) score below 24; CD a decline of 3 or more points in the MMSE without CI. At baseline, participants developing CI during follow-up scored significantly worse across all physical performance measures compared to those that retained normal cognitive status. After adjusting for potential confounders, a significant trend for MMSE changes was noted for all physical performance tests, except for the SPPB and chair stands time. Multinomial logistic regression revealed that slow gait speed at baseline significantly predicted CD at follow up. Poor SPPB performance and slower gait speed predicted the onset of CI at the follow-up. In conclusion, slow walking speed appears to be the best independent predictor of poor cognitive status over a 4.4-year follow-up, while other items of SPPB were also significantly associated with CI. PMID:27235850

  7. Survival and Toxicity in Patients With Disseminated Germ CellCancer Aged 40 Years and Older

    DEFF Research Database (Denmark)

    Thomsen, Frederik B; Bandak, Mikkel; Thomsen, Maria F;

    2014-01-01

    BACKGROUND: Germ-cell cancer (GCC) patients aged ≥40 years have a two-fold higher GCC-specific mortality. It has been hypothesized that reduced treatment intensity combined with increased treatment related toxicity could be the explanation. The objective was to analyze chemotherapy intensity......, etoposide and cisplatin (BEP). A control-group of 135 patients aged 18-35 years was randomly selected matched on year of BEP treatment. Cumulated doses of BEP as well as bone marrow toxicity, renal- and lung functions were recorded before, during and after termination of treatment. All patients were...... the two groups were found regarding bone marrow toxicity or mean percentage changes in lung- or renal function. Patients aged ≥40 year had increased cancer specific mortality, HR = 4.8 (P = 0.005). In particular patients with disease progression after first line chemotherapy had increased mortality (P...

  8. The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

    OpenAIRE

    Izaks, Gerbrand J.; Gansevoort, Ron T; van der Knaap, Aafke M.; Navis, Gerjan; Dullaart, Robin P.F.; Slaets, Joris P J

    2011-01-01

    APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain rea...

  9. GENES Y EVOLUCIÓN EL DELGADO HILO QUE NOS CONECTA POR MILES DE MILLONES DE AÑOS Genes and Evolution, the Thin Thread that Connects Us for Billions of Years

    Directory of Open Access Journals (Sweden)

    LUIS FERNANDO GARCÍA

    Full Text Available La escala temporal en nuestra cotidianidad refleja una pequeña fracción de la historia evolutiva de los organismos, incluidos los humanos. La edad del planeta se estima en 4.500 millones de años, donde ocurrieron profundos cambios en la posición de los continentes y en el clima del planeta. Sin embargo, los cambios más drásticos surgen solo en los últimos 500 millones de años. La genética ha sido una herramienta fundamental para inferir el cambio de los organismos a lo largo de millones de años, por ejemplo, mediante la estimación de tiempos de divergencia. Los seres vivos comparten el material genético como huellas moleculares para rastrear cambios en el pasado. Así, mediante el uso de secuencias de ADN y proteínas, los científicos estudian cómo los organismos han evolucionado, cuándo surgieron importantes novedades evolutivas, cómo interaccionan los genes, y determinan las relaciones evolutivas entre las formas del pasado y las contemporáneas. Las relaciones entre organismos son inferidas por simple similaridad (fenéticas, por compartir características únicas y mediante modelos matemáticos que describen como evolucionan las secuencias de ADN y las proteínas (filogenéticas. La genética también evidencia la dinámica de los genomas (duplicación, transposición, recombinación, inversiones, que resulta en ganancia y pérdida de genes, nuevas funciones, y transferencia horizontal de genes, mecanismos que incrementan la diversidad existente hoy. Aunque el ambiente es fundamental en la evolución de los organismos, es imprescindible reconocer que hay un hilo conductor muy fino y fuerte que nos conecta inevitablemente a esas primeras moléculas que se formaron en el pasado distante.The temporal scale of our daily life is a small fraction of the evolutionary history of organisms, including the humans. The planet age is estimated in 4.5 billion years, in which profound changes in the position of continents and the climate of

  10. Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial.

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    Isabelle Bourdel-Marchasson

    Full Text Available We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality.We conducted a multicentre, open-label interventional, stratified (centre, parallel randomised controlled trial, with a 1∶1 ratio, with two-year follow-up. Patients were aged 70 years or older treated with chemotherapy for solid tumour and at risk of malnutrition (MNA, Mini Nutritional Assessment 17-23.5. Intervention consisted of diet counselling with the aim of achieving an energy intake of 30 kCal/kg body weight/d and 1.2 g protein/kg/d, by face-to-face discussion targeting the main nutritional symptoms, compared to usual care. Interviews were performed 6 times during the chemotherapy sessions for 3 to 6 months. The primary endpoint was 1-year mortality and secondary endpoints were 2-year mortality, toxicities and chemotherapy outcomes.Between April 2007 and March 2010 we randomised 341 patients and 336 were analysed: mean (standard deviation age of 78.0 y (4·9, 51.2% male, mean MNA 20.2 (2.1. Distribution of cancer types was similar in the two groups; the most frequent were colon (22.4%, lymphoma (14.9%, lung (10.4%, and pancreas (17.0%. Both groups increased their dietary intake, but to a larger extent with intervention (p<0.01. At the second visit, the energy target was achieved in 57 (40.4% patients and the protein target in 66 (46.8% with the intervention compared respectively to 13 (13.5% and 20 (20.8% in the controls. Death occurred during the first year in 143 patients (42.56%, without difference according to the intervention (p = 0.79. No difference in nutritional status changes was found. Response to chemotherapy was also similar between the groups.Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality or secondary outcomes. Cancer cachexia antianabolism may explain this lack of effect.ClinicalTrials.gov NCT

  11. Prognosis of primary care patients aged 80 years and older with lower respiratory tract infection

    NARCIS (Netherlands)

    van de Nadort, Christiana; Smeets, Hugo M; Bont, Jettie; Zuithoff, N Peter A; Hak, Eelko; Verheij, Theo J M

    2009-01-01

    BACKGROUND: Predictors for a complicated course of a lower respiratory tract infection (LRTI) episode among patients aged > or =80 years are unknown. AIM: To determine prognostic factors for hospital admission or death within 30 days after first onset of LRTI among primary care patients aged > or =8

  12. Barriers to eye care among people aged 40 years and older with diagnosed diabetes, 2006-2010.

    Science.gov (United States)

    Chou, Chiu-Fang; Sherrod, Cheryl E; Zhang, Xinzhi; Barker, Lawrence E; Bullard, Kai McKeever; Crews, John E; Saaddine, Jinan B

    2014-01-01

    OBJECTIVE We examine barriers to receiving recommended eye care among people aged ≥40 years with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were asked the main reason why. We categorized the reasons as cost/lack of insurance, no need, no eye doctor/travel/appointment, and other (meaning everything else). We used multinomial logistic regression to control for race/ethnicity, education, income, and other selected covariates. RESULTS Among adults with diagnosed diabetes, nonadherence to the recommended annual eye examinations was 23.5%. The most commonly reported reasons for not receiving eye care in the preceding 12 months were "no need" and "cost or lack of insurance" (39.7 and 32.3%, respectively). Other reasons were "no eye doctor," "no transportation" or "could not get appointment" (6.4%), and "other" (21.5%). After controlling for covariates, adults aged 40-64 years were more likely than those aged ≥65 years (relative risk ratio [RRR] = 2.79; 95% CI 2.01-3.89) and women were more likely than men (RRR = 2.33; 95% CI 1.75-3.14) to report "cost or lack of insurance" as their main reason. However, people aged 40-64 years were less likely than those aged ≥65 years to report "no need" (RRR = 0.51; 95% CI 0.39-0.67) as their main reason. CONCLUSIONS Addressing concerns about "cost or lack of insurance" for adults under 65 years and "no perceived need" among those 65 years and older could help improve eye care service utilization among people with diabetes. PMID:24009300

  13. Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia

    OpenAIRE

    Yaffe, K; Falvey, C; Hamilton, N; Schwartz, AV; Simonsick, EM; Satterfield, S; Cauley, JA; Rosano, C.; Launer, LJ; Strotmeyer, ES; Harris, TB

    2012-01-01

    Objectives: To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. Design: Prospective cohort study. Setting: Health, Aging, and Body Composition Study at 2 community clinics. Participants: A total of 3069 elderly adults (mean age, 74.2 years; 42% black; 52% female). Main Outcome Measures: Participants completed the Modified Mini-Mental State Examinat...

  14. Remaining Life Expectancy With and Without Polypharmacy: A Register-Based Study of Swedes Aged 65 Years and Older

    Science.gov (United States)

    Wastesson, Jonas W.; Canudas-Romo, Vladimir; Lindahl-Jacobsen, Rune; Johnell, Kristina

    2016-01-01

    Objectives To investigate the remaining life expectancy with and without polypharmacy for Swedish women and men aged 65 years and older. Design Age-specific prevalence of polypharmacy from the nationwide Swedish Prescribed Drug Register (SPDR) combined with life tables from Statistics Sweden was used to calculate the survival function and remaining life expectancy with and without polypharmacy according to the Sullivan method. Setting Nationwide register-based study. Participants A total of 1,347,564 individuals aged 65 years and older who had been prescribed and dispensed a drug from July 1 to September 30, 2008. Measurements Polypharmacy was defined as the concurrent use of 5 or more drugs. Results At age 65 years, approximately 8 years of the 20 remaining years of life (41%) can be expected to be lived with polypharmacy. More than half of the remaining life expectancy will be spent with polypharmacy after the age of 75 years. Women had a longer life expectancy, but also lived more years with polypharmacy than men. Discussion Older women and men spend a considerable proportion of their lives with polypharmacy. Conclusion Given the negative health outcomes associated with polypharmacy, efforts should be made to reduce the number of years older adults spend with polypharmacy to minimize the risk of unwanted consequences. PMID:26341036

  15. Clinical outcome, and survival between primary percutaneous coronary intervention versus fibrinolysis in patients older than 60 years with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    H Falsoleiman

    2012-01-01

    Conclusion: The higher rates of heart failure and need for revascularization in the fibrinolysis group reinforces benefits of PPCI in patients older than 60 years. PPCI in those who are 60 years and above with AMI is safe and cost effective.

  16. Quality of Life in Rural and Urban Adults 65 Years and Older: Findings from the National Health and Nutrition Examination Survey

    Science.gov (United States)

    Baernholdt, Marianne; Yan, Guofen; Hinton, Ivora; Rose, Karen; Mattos, Meghan

    2012-01-01

    Purpose: The proportion of people over 65 years of age is higher in rural areas than in urban areas, and their numbers are expected to increase in the next decade. This study used Andersen's behavioral model to examine quality of life (QOL) in a nationally representative sample of community-dwelling adults 65 years and older according to…

  17. Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years

    Directory of Open Access Journals (Sweden)

    Ağaçayak KS

    2014-03-01

    Full Text Available Kamil Serkan Ağaçayak,1 Sedat Güven,2 Mahmut Koparal,1 Nedim Güneş,1 Yusuf Atalay,3 Serhat Atilgan11Department of Oral and Maxillofacial Surgery, 2Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakir, Turkey; 3Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Afyon Kocatepe, Afyon, TurkeyIntroduction: In this study, we investigated the effects of long-term antihypertensive treatment with calcium channel blockers or beta blockers on the bone mineral density of maxilla, as determined by cone-beam computed tomography (CBCT.Material and methods: This retrospective study was conducted on CBCT images of men older than 55 years who had received different dental indications. Data were grouped into three categories according to the antihypertensive medication history of the patients: group A included patients who had been taking beta-blocker treatment for more than 5 years, group B included patients who had been taking calcium channel blocker treatment for more than 5 years, and the control group included patients who had never used any hypertensive medications before.Results: Statistically significant differences were observed between the beta blocker and calcium channel blocker groups.Conclusion: In hypertension treatment, beta blockers may be preferred to calcium channel blockers in patients at high risk for osteoporosis and bone resorption.Keywords: bone mineral density, CBCT, beta blockers, calcium channel blockers

  18. Tolerability and outcomes of radiotherapy or chemoradiotherapy for rectal cancer in elderly patients aged 70 years and older

    International Nuclear Information System (INIS)

    To assess the safety and outcomes of radiotherapy (RT) or chemoradiotherapy (CRT) in elderly patients (≥70) with rectal cancer. Elderly patients aged 70 and older with rectal cancer, who were treated with RT or CRT at a single institution, were retrospectively analyzed. Performance status (KPS and ECOG score) and comorbidity (Charlson comorbidity index) were calculated, and their correlation with treatment toxicity and overall survival were studied. Risk factors for overall survival were investigated using univariate and multivariate survival analysis. A total of 126 patients with locally advanced disease, local recurrence or synchronous metastasis were included, with a 3-year OS rate of 48.1%. Scheduled dosage of radiation was delivered to 69% of patients. Grade 3 toxicities occurred more often in patients treated with CRT versus RT. The occurrence of grade 3 toxicities was not related to KPS score, ECOG score, number of comorbidities, and Charlson score. Multivariate analysis found that only age and Charlson score were independent prognostic factors for predicting patients’ 3-year OS. The 3-year OS rate was significantly higher in patients with Charlson score <4 vs Charlson score ≥4 (71.1% vs. 26.4%, P=0.0003). Although toxicities may be significant, elderly patients with rectal cancer of varied stages can be safely treated with RT or CRT with careful monitoring and frequent modification of treatment. Except for patients’ age, Charlson comorbidity index may be helpful in assessing patients’ outcomes in elderly patients with rectal cancer

  19. Falls and cognitive decline in Mexican Americans 75 years and older

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    Padubidri A

    2014-04-01

    Full Text Available Anokha Padubidri,1,2 Soham Al Snih,2,3 Rafael Samper-Ternent,2,4 Kyriakos S Markides,2,5 Kenneth J Ottenbacher,2,3 Mukaila A Raji2,6 1College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA; 2Sealy Center on Aging, 3Division of Rehabilitation Sciences, School of Health Professions, the University of Texas Medical Branch, Galveston, TX, USA; 4Department of Internal Medicine, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogota, Columbia; 5Department of Preventive Medicine and Community Health, 6Department of Internal Medicine, the University of Texas Medical Branch, Galveston, TX, USA Background: Little is known about long-term emotional and cognitive consequences of falls. We examined the association between falls and subsequent cognitive decline, and tested the hypothesis that depression would mediate any falls–cognition association among cognitively intact Hispanic Elders. Methods: We used data from the Hispanic Established Population for the Epidemiological Study of the Elderly to examine change in Mini Mental State Examination (MMSE scores over the 6-year period according to number of falls. All participants (N=1,119 had MMSE scores ≥21 and complete data on Center for Epidemiologic Studies of Depression Scale, social and demographic factors, medical conditions (diabetes, heart attack, stroke, and hypertension, and hand grip muscle strength. Results: At baseline, participants’ mean age was 80.8 years (range, 74–109, mean ­education was 6.3 years (range, 0–17, and mean MMSE was 25.2 (range, 21–30. Of the 1,119 ­participants, 15.8% experienced one fall and 14.4% had two or more falls. In mixed model analyses, having two or more falls was associated with greater decline in MMSE score (estimate =–0.81, standard error =0.19, P<0.0001 compared to having no fall, after adjusting for age, sex, marital status, and education. The magnitude of the association decreased (estimate

  20. A study of transcranial magnetic stimulation in older (>3 years patients of malnutrition.

    Directory of Open Access Journals (Sweden)

    Karak B

    1999-07-01

    Full Text Available Transcranial magnetic stimulation was performed in 40 subjects. Twenty patients in the age group of 3 to 8 years and having different grades of malnutrition were included in the ′study group′ whereas 20 normal children having no complaints comprised the ′control group′. The coil of the magnetic stimulator was applied tangentially over the vertex to stimulate the cortex. The motor evoked potential (MEP was obtained using root stimulation by applying the coil at the cervical and lumbosacral spines. Recordings were made from the abductor pollicis brevis (APB and extensor digitorum brevis (EDB muscles of both sides. Cortical threshold, latency and amplitude of motor evoked potential and central conduction time were recorded. Malnourished children showed significantly increased cortical threshold, prolonged cortical latency and central conduction time and reduction in amplitude of MEP. Observed delay in central motor conduction in malnourished children suggests asymptomatic involvement of corticospinal pathways.

  1. Factors Predicting Patient Dissatisfaction 2 Years After Discectomy for Lumbar Disc Herniation in a Chinese Older Cohort

    Science.gov (United States)

    Wang, Hui; Zhang, Di; Ma, Lei; Shen, Yong; Ding, Wenyuan

    2015-01-01

    Abstract We aim to identify factors predicting patient dissatisfaction 2 years after discectomy for lumbar disc herniation (LDH) in a Chinese older cohort. Preoperative and 2-year follow-up data for 843 patients were analyzed. After 2 years of discectomy, the patients rated their satisfaction by Patient Satisfaction Index (PSI), with response of 1 or 2 defining satisfaction and a PSI response of 3 or 4 defining dissatisfaction. Associations between perioperative variables and satisfaction with the results of surgery were examined in univariate and multivariate analysis. Six hundred fifty-seven patients had a PSI of 1 or 2 and were enrolled as satisfied group, 186 patients had a PSI of 3 or 4 and were enrolled as dissatisfied group. At baseline, no significant differences were found between the 2 groups in age, occupation, Oswestry Disability Index (ODI), Visual Analog Scale (VAS)-leg, and VAS-back. Compared to satisfied group, dissatisfied group had a significantly higher BMI and a higher incidence of depression. Two years after discectomy, no significant differences were found between the 2 groups in decrease of ODI, decrease of VAS-back, decrease of VAS-leg, surgery complications. Compared to satisfied group, dissatisfied group experienced higher incidence of symptom recurrence and depression. Logistic regression analysis showed that obesity, pre- and postoperative depression, symptom recurrence were independently associated with patient dissatisfaction 2 years after discectomy. In conclusion, more than 70% patients expressed satisfaction with discectomy for LDH. Two factors could predict patient dissatisfaction and be assessed before surgery: obesity and preoperative depression. Symptom recurrence and postoperative depression are also associated with diminished patient satisfaction. PMID:26448005

  2. Assessment of universal health coverage for adults aged 50 years or older with chronic illness in six middle-income countries

    OpenAIRE

    Goeppel, Christine; Frenz, Patricia; Grabenhenrich, Linus; Keil, Thomas; Tinnemann, Peter

    2016-01-01

    Abstract Objective To assess universal health coverage for adults aged 50 years or older with chronic illness in China, Ghana, India, Mexico, the Russian Federation and South Africa. Methods We obtained data on 16 631 participants aged 50 years or older who had at least one diagnosed chronic condition from the World Health Organization Study on Global Ageing and Adult Health. Access to basic chronic care and financial hardship were assessed and the influence of health insurance and rural or u...

  3. Assessment of the cardiovascular effects of electroconvulsive therapy in individuals older than 50 years

    Directory of Open Access Journals (Sweden)

    Takada J.Y.

    2005-01-01

    Full Text Available To evaluate the impact of electroconvulsive therapy on arterial blood pressure, heart rate, heart rate variability, and the occurrence of ischemia or arrhythmias, 38 (18 men depressive patients free from systemic diseases, 50 to 83 years old (mean: 64.7 ± 8.6 underwent electroconvulsive therapy. All patients were studied with simultaneous 24-h ambulatory blood pressure and Holter monitoring, starting 18 h before and continuing for 3 h after electroconvulsive therapy. Blood pressure, heart rate, heart rate variability, arrhythmias, and ischemic episodes were recorded. Before each session of electroconvulsive therapy, blood pressure and heart rate were in the normal range; supraventricular ectopic beats occurred in all patients and ventricular ectopic beats in 27/38; 2 patients had non-sustained ventricular tachycardia. After shock, systolic, mean and diastolic blood pressure increased 29, 25, and 24% (P < 0.001, respectively, and returned to baseline values within 1 h. Maximum, mean and minimum heart rate increased 56, 52, and 49% (P < 0.001, respectively, followed by a significant decrease within 5 min; heart rate gradually increased again thereafter and remained elevated for 1 h. Analysis of heart rate variability showed increased sympathetic activity during shock with a decrease in both sympathetic and parasympathetic drive afterwards. No serious adverse effects occurred; electroconvulsive therapy did not trigger any malignant arrhythmias or ischemia. In middle-aged and elderly people free from systemic diseases, electroconvulsive therapy caused transitory increases in blood pressure and heart rate and a decrease in heart rate variability but these changes were not associated with serious adverse clinical events.

  4. Clinical-epidemiological features of HIV-infected patients diagnosed at age of 50 years or older

    Directory of Open Access Journals (Sweden)

    V Fink

    2012-11-01

    Full Text Available HIV/AIDS prevention and care efforts are directed to individuals of reproductive age (15–49 yrs. With the extension of sexual life of older people, they became a growing population at risk of HIV infection, usually not included in prevention strategies. In order to evaluate clinical profile of HIV/AIDS pts diagnosed at 50 yrs or older assisted in an HIV outpatient center in Buenos Aires, we retrospectively assessed clinical records of pts initiating care between Jan 1986 and Dec 2011. Age, CD4 cells and viral load (pVL at HIV diagnosis and most recent value, opportunistic infections (OIs, co-morbidities and antiretroviral therapy (ARV were recorded. Of 10,998 pts assisted in the 26-yr period, 495 (4.5% were≥50 yrs old at HIV diagnosis; median annual diagnoses: 18.5 (IQR 3.3–30.3 without significant changes in the last 20 yrs. Demographics: median age 54.7 yrs (IQR 51.8–59.2, rank 50–80, 76.6% male. Risk behavior: HTX 61.4%, MSM 34.1%, others 4.4%. 55.4% of HIV diagnoses occurred during hospitalization or simultaneously with acute OIs. One third (n=176 had AIDS at diagnosis, 24% had history of STDs. HCV co-infection 5.7%, past HBV infection 28.1% and chronic HBV infection 5.1%. Median CD4 cells at HIV diagnosis: 223.5 (13.7% (IQR 98.8–420.3, initial pVL 60,000 cp/mL (IQR 9,995.5–208,391. 69.3% of pts started ARV therapy during follow-up (FU, and the median time between diagnosis and treatment initiation was 3.4 mo (IQR 0.7–14; 56.9% of them started a non-nucleoside-based regimen (ZDV/3TC/EFV, 28.3% a PI-based regimen (ZDV/3TC/IDV and 14.6% a nucleoside-based regimen (ZDV/ddI pre-HAART era. After a year (±6 mo, 63.8% pts achieved undetectable pVL and gained 136 CD4 cells from BSL (IQR 83–204. After 40.6 mo of FU (IQR 6.7-89.8, 66.3% are alive, 7.1% died (68.6% of HIV-related diseases and 26.7% are lost to FU. Co-morbidities were present in 125 (25.3%, mainly hypertension, increased lipids, CVD and DBT. Among treated pts, 70

  5. The harmonic ratio of trunk acceleration predicts falling among older people: results of a 1-year prospective study

    Directory of Open Access Journals (Sweden)

    Doi Takehiko

    2013-01-01

    Full Text Available Abstract Background Gait variables derived from trunk accelerometry may predict the risk of falls; however, their associations with falls are not fully understood. The purpose of the study was to determine which gait variables derived from upper and lower trunk accelerometry are associated with the incidence of falls, and to compare the discriminative ability of gait variables and physical performance. Methods This study was a 1-year prospective study. Older people (n = 73 walked normally while wearing accelerometers attached to the upper and lower trunk. Participants were classified as fallers (n = 16 or non-fallers (n = 57 based on the incidence of falls over 1 year. The harmonic ratio (HR of the upper and lower trunk was measured. Physical performance was measured in five chair stands and in the timed up and go test. Results The HR of the upper and lower trunk were consistently lower in fallers than non-fallers (P P Conclusions HR derived from upper trunk accelerometry may predict the risk of falls, independently of physical performance. The discriminative ability of HR for the risk of falls may have some validity, and further studies are needed to confirm the clinical relevance of trunk HR.

  6. Daily home gardening improved survival for older people with mobility limitations: an 11-year follow-up study in Taiwan

    Science.gov (United States)

    Lêng, Chhian Hūi; Wang, Jung-Der

    2016-01-01

    Aims To test the hypothesis that gardening is beneficial for survival after taking time-dependent comorbidities, mobility, and depression into account in a longitudinal middle-aged (50–64 years) and older (≥65 years) cohort in Taiwan. Methods The cohort contained 5,058 nationally sampled adults ≥50 years old from the Taiwan Longitudinal Study on Aging (1996–2007). Gardening was defined as growing flowers, gardening, or cultivating potted plants for pleasure with five different frequencies. We calculated hazard ratios for the mortality risks of gardening and adjusted the analysis for socioeconomic status, health behaviors and conditions, depression, mobility limitations, and comorbidities. Survival models also examined time-dependent effects and risks in each stratum contingent upon baseline mobility and depression. Sensitivity analyses used imputation methods for missing values. Results Daily home gardening was associated with a high survival rate (hazard ratio: 0.82; 95% confidence interval: 0.71–0.94). The benefits were robust for those with mobility limitations, but without depression at baseline (hazard ratio: 0.64, 95% confidence interval: 0.48–0.87) when adjusted for time-dependent comorbidities, mobility limitations, and depression. Chronic or relapsed depression weakened the protection of gardening. For those without mobility limitations and not depressed at baseline, gardening had no effect. Sensitivity analyses using different imputation methods yielded similar results and corroborated the hypothesis. Conclusion Daily gardening for pleasure was associated with reduced mortality for Taiwanese >50 years old with mobility limitations but without depression. PMID:27486315

  7. Sex, Race, and Age Differences in Observed Years of Life, Healthy Life, and Able Life among Older Adults in The Cardiovascular Health Study

    OpenAIRE

    Thielke, Stephen M.; Diehr, Paula H.; Yee, Laura M.; Arnold, Alice M.; Quiñones, Ana R.; Whitson, Heather E.; Mini E. Jacob; Newman, Anne B.

    2015-01-01

    Objective: Longevity fails to account for health and functional status during aging. We sought to quantify differences in years of total life, years of healthy life, and years of able life among groups defined by age, sex, and race. Design: Primary analysis of a cohort study. Setting: 18 years of annual evaluations in four U.S. communities. Participants: 5888 men and women aged 65 and older. Measurements: Years of life were calculated as the time from enrollment to death or 18 years. Years of...

  8. Comparison of transplant outcomes from matched sibling bone marrow or peripheral blood stem cell and unrelated cord blood in patients 50 years or older.

    Science.gov (United States)

    Konuma, Takaaki; Tsukada, Nobuhiro; Kanda, Junya; Uchida, Naoyuki; Ohno, Yuju; Miyakoshi, Shigesaburo; Kanamori, Heiwa; Hidaka, Michihiro; Sakura, Toru; Onizuka, Makoto; Kobayashi, Naoki; Sawa, Masashi; Eto, Tetsuya; Matsuhashi, Yoshiko; Kato, Koji; Ichinohe, Tatsuo; Atsuta, Yoshiko; Miyamura, Koichi

    2016-05-01

    Older recipient and donor age were associated with higher incidences of severe graft-versus-host disease (GVHD) and mortality after allogeneic hematopoietic stem cell transplantation from matched sibling donors (MSDs) and matched unrelated donors. Since a lower incidence of severe GVHD is advantageous in unrelated cord blood transplantation (CBT), a higher incidence of GVHD using older MSDs could be overcome using cord blood for older patients. We retrospectively analyzed Japanese registration data of 2,091 patients with acute myeloid leukemia, acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome aged 50 years or older who underwent MSD bone marrow transplantation (BMT) (n = 319), MSD peripheral blood stem cell transplantation (PBSCT) (n = 462), or unrelated CBT (n = 1,310) between 2007 and 2012. Median age of MSD was 56 (range, 38-74) years. Compared with CBT, the risk of developing extensive chronic GVHD was higher after BMT (hazard ratio [HR], 2.00; P = 0.001) or PBSCT (HR, 2.38; P CBT, the rates of a composite endpoint of GVHD-free, relapse-free survival (GRFS) were not significant difference between three groups. These data showed that MSDs remain the best donor source for older patients, but CBT led to similar GRFS to BMT and PBSCT. Am. J. Hematol. 91:E284-E292, 2016. © 2016 Wiley Periodicals, Inc. PMID:26910296

  9. Dairy Consumption and the Risk of 15-Year Cardiovascular Disease Mortality in a Cohort of Older Australians

    Directory of Open Access Journals (Sweden)

    Timothy P. Gill

    2013-02-01

    Full Text Available The effects of habitual dairy consumption and the risk of 15-year cardiovascular disease (CVD mortality in a cohort of older Australians were investigated. Participants (n = 2900 completed a validated 145-item semi-quantitative food frequency questionnaire. Cox proportional hazards regression models were used to investigate associations between tertiles of the dairy consumption, including low/reduced fat dairy, whole fat dairy and their ratio (ratioLF/WF, and risk of mortality from coronary heart disease (CHD, stroke or combined CVD. There were 548 recorded cases of CVD mortality in this cohort. For total dairy intake, a reduction in risk of CVD was only seen in tertile 2 (adjusted hazard ratio, AHR: 0.71; 95% CI: 0.55–0.93, and for CHD both tertile 2 and tertile 3 were associated with a reduced risk (both with AHR: 0.71. However there were no linear trends between total dairy consumption and any of the three outcomes. There were no associations or trends between low/reduced fat dairy or whole fat dairy consumption, or ratioLF/WF and any of the three outcomes in the fully adjusted model (all p > 0.05. This study found no consistent association between baseline consumption of dairy foods and the risk of CHD, stroke and combined CVD mortality.

  10. A Six-Year Follow-Up Study of Social Network Changes among African-American, Caribbean, and U.S.-Born Caucasian Urban Older Adults

    Science.gov (United States)

    Conway, Francine; Magai, Carol; Jones, Samuel; Fiori, Katherine; Gillespie, Michael

    2013-01-01

    This study explores dynamic changes in network size and composition by examining patterns of older adults' social network change over time, that is: types of movements; the reason for the loss of network members; and the relation of movement and composition in concert. This study is a 6-year follow up of changes in the social networks of U.S.-Born…

  11. Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older

    OpenAIRE

    Gschwind, Yves J; Bischoff-Ferrari, Heike A; Bridenbaugh, Stephanie A; Härdi, Irene; Kressig, Reto W

    2014-01-01

    Background: Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. Objective: The aim of this study was to determine the association between serum 25-hydroxyvitamin D [25(OH)D] status and functional mobility in seniors assessed in a memory clinic. Methods: We conducted a cross-sectional study of outpati...

  12. Trends in AIDS Incidence in Individuals Aged 50 Years or Older in the City of Rio de Janeiro, Brazil, 1982–2011: An Age-Period-Cohort Analysis

    Directory of Open Access Journals (Sweden)

    Paulo Cavalcante Apratto Junior

    2014-07-01

    Full Text Available Objective: The aim of this study was to investigate the effects of three temporal components of AIDS incidence (i.e., age, period and cohort on individuals aged 50 or older living in Niteroi, Rio de Janeiro (Brazil. Methods: Age-specific incidence rates were calculated from 1982–2011. Negative binomial and Poisson models were used to analyze the risk of AIDS by age, period and cohort. Results: The risk of AIDS in men was 2.45 times higher than in women, regardless of age and period (p-value < 0.001. The incidence of AIDS in individuals older than 69 years was 7-fold lower than in those aged 50–59 years (p-value < 0.001. A decreasing trend in AIDS risk was observed from the youngest cohort (≥1940 to the oldest (1910–1919. From 1982 to 2006, we could detect an increasing trend in AIDS risk in the population aged 50 years or older. A peak in rates was detected in the period from 2002–2006. The incidence rates in 2002–2006 were six times higher than those in 1987–1991 (p-value < 0.001, independent of age and sex (p-value < 0.001. Conclusions: An increase of AIDS risk in older people was detected. This group should not be neglected by public health programs.

  13. Does Playing Sports Video Games Predict Increased Involvement in Real-Life Sports Over Several Years Among Older Adolescents and Emerging Adults?

    Science.gov (United States)

    Adachi, Paul J C; Willoughby, Teena

    2016-02-01

    Given the extreme popularity of video games among older adolescents and emerging adults, the investigation of positive outcomes of video game play during these developmental periods is crucial. An important direction for research in this area is the investigation of a link between sports video game play and involvement in real-life sports among youth. Yet, this association has not been examined in the long-term among older adolescents and emerging adults, and thus represents an exciting new area for discovery. The primary goal of the current study, therefore, was to examine the long-term association between sports video game play and involvement in real-life sports clubs among older adolescents and emerging adults. In addition, we examined whether self-esteem was an underlying mechanism of this longitudinal association. We surveyed older adolescents and emerging adults (N = 1132; 70.6 % female; M age = 19.06 years, range of 17-25 years at the first assessment) annually over 3 years about their video game play, self-esteem, and involvement in real-life sports. We found a long-term predictive effect of sports video game play on increased involvement in real-life sports over the 3 years. Furthermore, we demonstrated that self-esteem was an underlying mechanism of this long-term association. Our findings make an important contribution to an emerging body of literature on the positive outcomes of video game play, as they suggest that sports video game play may be an effective tool to promote real-life sports participation and physical activity among older adolescents and emerging adults. PMID:26033045

  14. Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives

    Directory of Open Access Journals (Sweden)

    Jae-Sung Lim

    2010-09-01

    Full Text Available Jae-Sung Lim1, Hyung-Min Kwon21Department of Neurology, Armed Forces Seoul Hospital, Seoul, Republic of Korea; 2Department of Neurology, Seoul National University Boramae Hospital, Seoul, Republic of KoreaAbstract: With the increasing size of the elderly population and evolving imaging technology, silent brain infarction (SBI has garnered attention from both the public and the physicians. Over 20% of the elderly exhibit SBI, and the prevalence of SBI increases steadily with age, ie, 30%–40% in those older than 70 years. Well-known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI (odds ratio [OR] = 3.47 Besides this, blood pressure (BP reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR = 2.18 but also as individual components could have an influence on SBI. Increased C-reactive protein and interleukin-6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and ­possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] = 1.9, 95% confidence interval [CI]; 1.2–2.8; dementia: HR = 2.26, 95% CI: 1.09–4.70. We also looked into their close relationship with SBI in this review.Keywords: silent brain infarction, elderly, risk factors, treatment

  15. Outcome and survival of patients aged 75 years and older compared to younger patients after ruptured abdominal aortic aneurysm repair: do the results justify the effort?

    DEFF Research Database (Denmark)

    Shahidi, S; Schroeder, T Veith; Carstensen, M.;

    2009-01-01

    were also performed with the variables that were found to be significant in the univariate analysis. Health economy and cost analysis for the two groups were estimated. Out of 72 open repairs of RAAA, 44 patients (61%) were under 75 years of age and 28 (39%) were 75 years or older. The average age of...... elderly because of the increased incidence of surgical risk factors and hospital mortality in this subset of patients (cut-off age). Demographic, clinical, and operative factors were analyzed together with 30-day mortality. Univariate analysis was performed with the chi-squared test. Multivariate analyses......%-33%) of 44 younger patients (p < 0.001). An age of 75 years or older and a serum creatinine >or=0.150 mmol/L in elderly patients with RAAA (p < 0.01) were identified to be significant risk factors for operative mortality. We did not encounter significant differences in the distribution of other risk...

  16. Influenza Vaccination Among Adults 65 Years or Older: A 2009–2010 Community Health Survey in the Honam Region of Korea

    Directory of Open Access Journals (Sweden)

    Hyung Su Park

    2011-11-01

    Full Text Available The present study examined the rates and related factors for influenza vaccination among the elderly Korean population during the 2008/09 influenza seasons. We obtained data for 6,391 adults aged 65 years or older from Community Health Surveys conducted in 2009 and 2010 in 13 communities in the Honam region of Korea. A multiple logistic regression analysis was used to identify the factors associated with self-reported influenza vaccinations. In this elderly population, 81.7% reported to having received an influenza vaccination in the past year. The main contributing factors were older age, lower economic status, lower educational level, married, non-smoking, regular alcohol consumption, regular walking exercise, receiving a health check-up during the past two years, not stressed, and having comorbid conditions. The influenza vaccination coverage rate among elderly Koreans was relatively high, but improvements in vaccination rates are required.

  17. Endemic Cardiovascular Diseases of the Poorest Billion.

    Science.gov (United States)

    Kwan, Gene F; Mayosi, Bongani M; Mocumbi, Ana O; Miranda, J Jaime; Ezzati, Majid; Jain, Yogesh; Robles, Gisela; Benjamin, Emelia J; Subramanian, S V; Bukhman, Gene

    2016-06-14

    The poorest billion people are distributed throughout the world, though most are concentrated in rural sub-Saharan Africa and South Asia. Cardiovascular disease (CVD) data can be sparse in low- and middle-income countries beyond urban centers. Despite this urban bias, CVD registries from the poorest countries have long revealed a predominance of nonatherosclerotic stroke, hypertensive heart disease, nonischemic and Chagas cardiomyopathies, rheumatic heart disease, and congenital heart anomalies, among others. Ischemic heart disease has been relatively uncommon. Here, we summarize what is known about the epidemiology of CVDs among the world's poorest people and evaluate the relevance of global targets for CVD control in this population. We assessed both primary data sources, and the 2013 Global Burden of Disease Study modeled estimates in the world's 16 poorest countries where 62% of the population are among the poorest billion. We found that ischemic heart disease accounted for only 12% of the combined CVD and congenital heart anomaly disability-adjusted life years (DALYs) in the poorest countries, compared with 51% of DALYs in high-income countries. We found that as little as 53% of the combined CVD and congenital heart anomaly burden (1629/3049 DALYs per 100 000) was attributed to behavioral or metabolic risk factors in the poorest countries (eg, in Niger, 82% of the population among the poorest billion) compared with 85% of the combined CVD and congenital heart anomaly burden (4439/5199 DALYs) in high-income countries. Further, of the combined CVD and congenital heart anomaly burden, 34% was accrued in people under age 30 years in the poorest countries, while only 3% is accrued under age 30 years in high-income countries. We conclude although the current global targets for noncommunicable disease and CVD control will help diminish premature CVD death in the poorest populations, they are not sufficient. Specifically, the current framework (1) excludes deaths of

  18. Characteristics of problem gamblers 56 years of age or older: a statewide study of casino self-excluders.

    Science.gov (United States)

    Nower, Lia; Blaszczynski, Alex

    2008-09-01

    Gambling among older adults appears to be increasing, though little is known about the characteristics of older adult problem gamblers. The purpose of this study was to compare older adults to younger and middle-aged adults in a cohort of problem gamblers participating in a state-administered casino self-exclusion program. Self-reported problem gamblers (N = 1,601) who voluntary banned themselves from Missouri casinos from 2001 to 2003 were categorized by age as younger adults (ages 21 to 35; n = 490), middle-aged adults (ages 36 to 55; n = 950), and older adults (ages 56 to 79; n = 161), and were compared with respect to demographic variables, gambling participation, and reasons for self-exclusion. Older adult self-excluders typically began gambling in midlife, experienced gambling problems around age 60, reported preferences for nonstrategic forms of gambling, and identified fear of suicide as the primary reason for self-excluding. Implications for intervention, prevention and treatment are discussed. PMID:18808247

  19. Life styles related to coronary artery disease in Saudi males older than 12 years of age life styles related to coronary artery disease in Saudi males older than 12 years of age

    International Nuclear Information System (INIS)

    The present study highlighted life styles related to coronary artery disease risk factors among patients attending a primary care clinic at King Khalid University Hospital, in Riyadh, Saudi Arabia Methods: We conducted a cross-sectional study at a primary care clinic at King Khalid University Hospital, Riyadh, Saudi Arabia, during the period from 18/4/2006 to 13/6/2006. All adult male patients older than 12 years of age who attended one consultant primary care clinic were included in the study. All patients were interviewed by one consultant in family medicine during the study period. The patients were asked about dietary habits, physical activity and type of exercise, and smoking habits. Weight and height was taken for all patients by the nurse in the clinic and body mass index (BMI) was calculated for all patients. The total numbers of participants were 246 patients. The data were analyzed using the Statistical Package of Social Science (SPSS) version 11.5. A p value of less than 0.05 was considered statistically significant. Results: Of the 246 male adult patients, 45.4% always consumed vegetables and fruits in their diet, 21.5% exercised on a daily bases, 51.2% exercised sometimes, and 26% did not exercise at all. The type of exercise practiced by active participants was walking (76.5%) and sports (22.9%). Sports included football, basketball, swimming, and other sport club activity. Only 20.7% of the participants had an ideal body weight (BMI<25), 37.4% were overweight (BMI 25 to <30), while 37.7% of the participants were obese (BMI ? 30). 8.9% of the participants were current smokers. Conclusion and recommendation: Overweight and obesity is a common health problem among male adult patients attending a primary care setting. Improved dietary habits (consumption of vegetables and fruits, and minimization of fat and sweets), encouraging exercise and walking, and helping current smokers to quit smoking are essential steps towards improving life styles in the

  20. Role of physical activity, physical fitness, and chronic health conditions on the physical independence of community-dwelling older adults over a 5-year period.

    Science.gov (United States)

    Pereira, Catarina; Baptista, Fátima; Cruz-Ferreira, Ana

    2016-01-01

    The variability in the individual characteristics and habits could help determine how older adults maintain independence. The impact of the variability in physical activity, physical fitness, body composition, and chronic health conditions (co-morbidities) on the independence of older adults, especially over time, is seldom examined. This study aims to analyze quantitatively the impact of baseline values and changes in physical activity, physical fitness, body composition, and co-morbidities on the physical independence of community-dwelling, older adults over a 5-year period. Data from 106 and 85 community-dwelling adults (≥60 years) were collected at baseline and after five years, respectively. Linear regression selected the main predictors of changes in physical independence as follows: the baseline physical independence (β=0.032, R(2)=9.9%) and co-morbidities (β=-0.191, R(2)=6.3%) and the changes in co-morbidities (β=-0.244, R(2)=10.8%), agility (β=-0.288, R(2)=6.7%), aerobic endurance (β=0.007, R(2)=3.2%), and walking expenditure (β=0.001, R(2)=5.1%) (pindependence, baseline co-morbidities, and changes in co-morbidities, walking, agility, and aerobic endurance predicted physical independence over five years regardless of age and gender. Gains of up to 8.3% in physical independence were associated with improvements in these variables, which corresponds to regaining independence for performing one or two activities of daily living. PMID:26966842

  1. A randomized trial to evaluate the effectiveness of an individual, education-based safe transport program for drivers aged 75 years and older

    Directory of Open Access Journals (Sweden)

    Keay Lisa

    2013-02-01

    Full Text Available Abstract Background There are concerns over safety of older drivers due to increased crash involvement and vulnerability to injury. However, loss of driving privileges can dramatically reduce independence and quality of life for older members of the community. The aim of this trial is to examine the effectiveness of a safe transport program for drivers aged 75 years and older at reducing driving exposure but maintaining mobility. Methods and design A randomised trial will be conducted, involving 380 drivers aged 75 years and older, resident in urban and semi-rural areas of North-West Sydney. The intervention is an education program based on the Knowledge Enhances Your Safety (KEYS program, adapted for the Australian context. Driving experience will be measured objectively using an in-vehicle monitoring device which includes a global positioning system (GPS to assess driving exposure and an accelerometer to detect rapid deceleration events. Participation will be assessed using the Keele Assessment of Participation (KAP. Data will be analysed on an intention-to-treat basis; the primary outcomes include driving exposure, rapid deceleration events and scores for KAP. Secondary outcomes include self-reported measures of driving, socialisation, uptake of alternative forms of transport, depressive symptoms and mood. A detailed process evaluation will be conducted, including examination of the delivery of the program and uptake of alternative forms of transport. A subgroup analysis is planned for drivers with reduced function as characterized by established cut-off scores on the Drivesafe assessment tool. Discussion This randomised trial is powered to provide an objective assessment of the efficacy of an individually tailored education and alternative transportation program to promote safety of older drivers but maintain mobility. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12612000543886.

  2. Supervision of care networks for frail community dwelling adults aged 75 years and older: Protocol of a mixed methods study

    NARCIS (Netherlands)

    D. Verver; H. Merten (Hanneke); P.B.M. Robben (Paul); C. Wagner (Cordula)

    2015-01-01

    textabstractIntroduction: The Dutch healthcare inspectorate (IGZ) supervises the quality and safety of healthcare in the Netherlands. Owing to the growing population of (community dwelling) older adults and changes in the Dutch healthcare system, the IGZ is exploring new methods to effectively super

  3. Sleep duration and mortality among older adults in a 22-year follow-up study: an analysis of possible effect modifiers

    OpenAIRE

    Zawisza, Katarzyna; Tobiasz-Adamczyk, Beata; Galas, Aleksander; Brzyska, Monika

    2014-01-01

    The aim of this study was to assess the relationship of sleep duration and all-cause mortality among 2,449 Polish community-dwelling older citizens of Krakow observed during 22 years of follow-up. In particular, the role of some demographic, psychosocial and health-related conditions were investigated in terms of modification effect. In the prospective study, background information was gathered by face-to-face interview. Vital data were obtained from the population registry. Cox regression mo...

  4. Association between the metabolic syndrome and its components and gait speed among U.S. adults aged 50 years and older: a cross-sectional analysis

    OpenAIRE

    Strine Tara W; Balluz Lina S; Ford Earl S; Zhong Yuna; Okoro Catherine A; Mokdad Ali H

    2006-01-01

    Abstract Background To examine the relationship between the metabolic syndrome and its components and gait speed among older U.S. men and women. Whether these associations are independent of physical activity was also explored. Methods Eight hundred and thirty-five men and 850 women aged ≥50 years from the continuous National Health and Nutrition Examination Survey 1999–2002 were examined. We used the definition of the metabolic syndrome developed by the U.S. National Cholesterol Education Pr...

  5. Qualitative Assessment of the Impact of Implementing Reiki Training in a Supported Residence for People Older Than 50 Years with HIV/AIDS

    OpenAIRE

    Mehl-Madrona, Lewis; Renfrew, Nita M; Mainguy, Barbara

    2011-01-01

    Introduction: Reiki is a Japanese form of energy healing that has become popular in the US. Reiki training involves three stages—levels I, II, and III—to a master practitioner level and requires both giving and receiving Reiki. We set out to implement a program to train clients of a supported residence in Brooklyn, NY. They were all older than age 50 years and had HIV/AIDS and substance-abuse and/or mental-health disorders.

  6. Remaining Life Expectancy With and Without Polypharmacy: A Register-Based Study of Swedes Aged 65 Years and Older

    OpenAIRE

    Wastesson, Jonas W.; Canudas-Romo, Vladimir; Lindahl-Jacobsen, Rune; Johnell, Kristina

    2016-01-01

    Objectives To investigate the remaining life expectancy with and without polypharmacy for Swedish women and men aged 65 years and older. Design Age-specific prevalence of polypharmacy from the nationwide Swedish Prescribed Drug Register (SPDR) combined with life tables from Statistics Sweden was used to calculate the survival function and remaining life expectancy with and without polypharmacy according to the Sullivan method. Setting Nationwide register-based study. Participants A total of 1...

  7. Achados oculares em pacientes com mais de 99 anos Ocular findings in patients older than 99 years

    Directory of Open Access Journals (Sweden)

    Marcela Colussi Cypel

    2006-10-01

    desenvolvimento de política específica de saúde ocular. Esse estudo demonstrou idosos com maioria do sexo feminino (83,3%, boa saúde geral (35%, hipertensos (40%, com dificuldade para leitura (55% e com baixa visual em decorrência de degeneração macular relacionada à idade.PURPOSE: To determine vision conditions and ocular findings in patients older than 99 years. METHODS: Patients were recruited by media advertisement and examined at the Vision Institute of UNIFESP. The following examinations were performed: visual acuity, ectoscopy, refraction, biomicroscopy, tear film break-up time, Schirmer basal test, tonometry, direct and indirect ophthalmoscopy. Complementary examinations such as optical coherence tomography were performed when indicated. RESULTS: Thirty patients older than 99 years were identified. Mean age of 101.5±1.8, 25 females and 5 males. Most common systemic disease, according to history, was arterial hypertension. In 11 patients (55%, the best corrected far visual acuity was 20/100 or better. The best corrected near visual acuity was J4 or better also in 55% (11 patients and 63.0% (7 patients of these were the ones that had not been submitted to cataract surgery. The most frequent visual complaint was low vision for reading (55% and other 8 patients (40% reported no disturbance (satisfied with their vision. Lens opacity was present in 9 patients (60% and 8 patients (40% had previous cataract surgery (5 aphakic eyes, 9 pseudophakic eyes. Cataract was identified as important for impairment of vision in 5 patients but only 2 of them wanted to be submitted to surgery. The main cause of visual impairment was age-related macular degeneration, present in all patients, 95% with no exudative form. Vision improved with new refractive prescription in 4 patients. CONCLUSION: Once we understand the needs we can plan specific diagnostic and treatment strategies. This sample showed that most were female (83.3%, with good general health (35%, most with systemic arterial

  8. In patients older than 55 years with AML in first CR, should we search for a matched unrelated donor when an old sibling donor is available?

    DEFF Research Database (Denmark)

    Peffault de Latour, R; Labopin, M; Cornelissen, J;

    2015-01-01

    Allogeneic hematopoietic transplantation is increasingly used in patients aged 55 years or more with AML. The question of whether outcomes can be improved with an allele-level 8/8 HLA-matched unrelated donor (MUD) rather than an older HLA-matched sibling (MSD, more than 55 years) is still...... unanswered. We thus analyzed outcomes in 714 patients aged 55 years and older with AML in first CR (CR1) who received PBSCs after a reduced-intensity conditioning hematopoietic cell transplant from a MUD (n=310) or a MSD (n=404) in a recent period (2005-2010). The 3-year cumulative incidences (CIs) of non......-relapse mortality were 17% and 23% with MSD and MUD, respectively (P=0.17). The 3-year CIs of relapse were 37% and 30%, respectively (P=0.12), resulting in a 3-year CI of leukemia-free survival of 46% and 47%, respectively (P=0.51). The 3-year overall survival was 49% with both MSD and MUD. In conclusion, HLA...

  9. Depression symptoms and cognitive-deficit in a population aged 60 years and older in a medium-sized city in São Paulo state, Brazil

    Directory of Open Access Journals (Sweden)

    José Evandro Marques Gomes

    2011-05-01

    Full Text Available Introduction: the world population is ageing, and Brazil follows this tendency, which requires the reorganization of society for care provision to older people. In such tendency, an increasing number of cases of depression and dementia is observed in addition to their association with other chronic-degenerative diseases. Objective: to estimate the prevalence of depression and cognitive-deficit symptoms in a population aged 60 years and older, residing in a middle-sized city in São Paulo state and to associate the population with other more prevalent chronic degenerative diseases. Methods: cross-sectional study on 364 older people using the following instruments: socio-demographic and morbidity, Mini Mental State Examination, Yesavage Scale, the Activities of Daily Living Scale, and the Instrumental Activities of Daily Living (IADL Scale. The following were performed: statistical analyses of the instruments’ score frequencies; presentation and summarization of the variables; and the possible associations between depression/dementia by applying the X2 test followed by fitting of a logistic regression model for ordinal data. Results: the suspected depression was found in 44% (160, and cognitive deficit was observed in 38.7% (141 aged. About 75% of the individuals with suspicion of depression or cognitive deficit had at least another chronic pathology. It was possible to establish statistically significant associations between suspected depression and IADL (p<0.0001; OR=7.59; CI=3.361-7.139 and cognitive deficit and IADL (p=0.0007; OR=3.967; CI=1.788-8.799. No associations were found between age, marital status, schooling, placement in the work market, retirement or income. Conclusion: male and female older individuals are vulnerable to diseases, such as depression and dementia. On the other hand, depression symptoms and cognitive deficit were associated with the score of compromised older individuals, according to IADL.

  10. Urban Poor Receive RMB7.1 Billion Cash Help

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    All levels of government have teamed up to dole out more than RMB7.1 billion (US$855.42 million) during the ilrst half of this year to help more than 21 million Chinese urban residents who are living below the minimum standard of living.

  11. Increasing and Decreasing Alcohol Use Trajectories Among Older Women in the U.S. Across a 10-Year Interval

    Directory of Open Access Journals (Sweden)

    Janet Kay Bobo

    2011-08-01

    Full Text Available Older women who routinely drink alcohol may experience health benefits, but they are also at risk for adverse effects. Despite the importance of their drinking patterns, few studies have analyzed longitudinal data on changes in drinking among community-based samples of women ages 50 and older. Reported here are findings from a semi-parametric group-based model that used data from 4,439 randomly sampled U.S. women who enrolled in the Health and Retirement Study (HRS and completed ≥3 biannual alcohol assessments during 1998–2008. The best-fitting model based on the drinks per day data had four trajectories labeled as “Increasing Drinkers” (5.3% of sample, “Decreasing Drinkers” (5.9%, “Stable Drinkers” (24.2%, and “Non/Infrequent Drinkers” (64.6%. Using group assignments generated by the trajectory model, one adjusted logistic regression analysis contrasted the groups with low alcohol intake in 1998 (Increasing Drinkers and Non/Infrequent Drinkers. In this model, baseline education, physical activity, cigarette smoking, and binge drinking were significant factors. Another analysis compared the groups with higher intake in 1998 (Decreasing Drinkers versus Stable Drinkers. In this comparison, baseline depression, cigarette smoking, binge drinking, and retirement status were significant. Findings underscore the need to periodically counsel all older women on the risks and benefits of alcohol use.

  12. Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study

    Directory of Open Access Journals (Sweden)

    Kemmler W

    2015-10-01

    Full Text Available Wolfgang Kemmler,1 Marc Teschler,1 Sabine Goisser,2 Michael Bebenek,1 Simon von Stengel,1 Leo Cornelius Bollheimer,2,3 Cornel C Sieber,2,3 Ellen Freiberger2 1Institute of Medical Physics, University of Erlangen-Nürnberg, Erlangen, Germany; 2Institute for Biomedicine of Aging, University Erlangen-Nürnberg, Nürnberg, Germany; 3Department of General Internal Medicine and Geriatrics, St John of God Hospital, Regensburg, GermanyBackground: Although sarcopenia represents a challenging burden for health care systems around the world, its prevalence in the elderly population varies widely. The primary aim of the study was to determine the prevalence of sarcopenia in community-dwelling (CD German women aged 70 years and older; the secondary aim was to assess the effect of osteoarthritis (OA on sarcopenia prevalence in this cohort.Methods: A total of 689 Caucasian females 18–35 years old and 1,325 CD females 70 years+ living in Northern Bavaria, Germany, were assessed during the initial phase of the FORMoSA research project. Anthropometry, total and regional muscle mass, were assessed by segmental multifrequency Bioelectrical Impedance Analysis. Further 10 m walking speed and handgrip strength were evaluated to apply the European Working Group on Sarcopenia in Older People definition of sarcopenia. Covariates were determined by questionnaires and interviews.Results: Applying the algorithm of the European Working Group on Sarcopenia in Older People of two standard deviations below the mean value for appendicular skeletal muscle mass of a reference cohort of the young cohort (5.66 kg/m2, low gait speed (≤0.8 m/s, and low grip strength (<20 kg, the prevalence of sarcopenia in CD German females 70 years and older was 4.5% (70–79 years: 2.8% vs ≥80 years: 9.9%; P<0.001. Participants with OA at the hip and lower limbs (n=252 exhibited significantly higher rates of sarcopenia (OA: 9.1 vs non-OA: 3.5%. Of importance, anthropometric, demographic

  13. The frequency of atheromas in panoramic radiographs of patients with periodontal disease, 40 year and older attending the University Dental Clinic

    International Nuclear Information System (INIS)

    The aim of the present study was to determine the frequency of atheromas in panoramic radiographic in patients 40 years and older with periodontal diseases attending the Dental School 'Roberto Beltran Neira' in the Universidad Peruana Cayetano Heredia, during the period 2000 and 2004. The sample consisted of 217 random panoramic radiographic with no systematically selected subjects. Variables were analyzed using frequency tables and the chi-square test. Results showed the frequency of atheromas was of 17.1% and the highest number of atheromas appeared between the ages of 40 and 59 years, mostly of feminine sex. (author)

  14. Older Drivers

    Science.gov (United States)

    ... Divisions Staff Visitor Information Contact Us FAQs Stay Connected Home » Older Drivers Heath and Aging Older ... She’s noticed a few new dents on her car and doesn’t know how they got there. ...

  15. Older Drivers

    Science.gov (United States)

    ... be more older drivers on the road. A Complex Task Click for more information Driving is a ... common for people to have declines in visual, thinking, or physical abilities as they get older. As ...

  16. A Billion Is How Big?

    Science.gov (United States)

    Gough, John

    2008-01-01

    Place-value is a central, powerful mathematical concept. From the earliest years of school, students focus on developing strong understanding of the ideas, notation and computational use. Many times, however, they get as far as thousands and then resort to waving their hands--at least until they start a far more advanced and abstract treatment of…

  17. Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study.

    Science.gov (United States)

    Tumati, Shankar; Burger, Huibert; Martens, Sander; van der Schouw, Yvonne T; Aleman, André

    2016-01-01

    Low levels of insulin-like growth factor-1 (IGF-1), an essential neurotrophic factor, have been associated with worse cognitive function in older adults. However, few studies have assessed the prospective association of serum IGF-1 with cognitive function. We aimed to determine the association between serum IGF-1 on concurrent and prospective cognitive function in a population sample of men aged 40-80 years. Blood samples were assessed for IGF-1 levels at baseline and neuropsychological assessments were performed at baseline (n = 400) and at follow-up after a mean duration of 8.3 years (n = 286). Linear regression analyses were carried out to determine the associations between quintiles of IGF-1 and cognitive function at the baseline and follow-up visits. Results showed that those in the top quintile of IGF-1 had lower processing capacity and global cognition scores at follow-up after controlling for cognitive function at baseline and other confounding factors. Additional analyses exploring associations with IGF-1 separately in middle-aged and older participants, and with quartiles of IGF-1 produced similar results. In those older than 60 years, high IGF-1 levels were also associated with lower baseline processing capacity. These results suggest that high IGF-1 levels are associated with worse long-term cognition in men. Together with past studies, we suggest that both, high and low levels of IGF-1 may be associated with poor cognitive function and that optimum levels of IGF-1 (quintile 2 and 3 in current study) may be associated with better cognitive function. PMID:27115487

  18. Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study.

    Directory of Open Access Journals (Sweden)

    Shankar Tumati

    Full Text Available Low levels of insulin-like growth factor-1 (IGF-1, an essential neurotrophic factor, have been associated with worse cognitive function in older adults. However, few studies have assessed the prospective association of serum IGF-1 with cognitive function. We aimed to determine the association between serum IGF-1 on concurrent and prospective cognitive function in a population sample of men aged 40-80 years. Blood samples were assessed for IGF-1 levels at baseline and neuropsychological assessments were performed at baseline (n = 400 and at follow-up after a mean duration of 8.3 years (n = 286. Linear regression analyses were carried out to determine the associations between quintiles of IGF-1 and cognitive function at the baseline and follow-up visits. Results showed that those in the top quintile of IGF-1 had lower processing capacity and global cognition scores at follow-up after controlling for cognitive function at baseline and other confounding factors. Additional analyses exploring associations with IGF-1 separately in middle-aged and older participants, and with quartiles of IGF-1 produced similar results. In those older than 60 years, high IGF-1 levels were also associated with lower baseline processing capacity. These results suggest that high IGF-1 levels are associated with worse long-term cognition in men. Together with past studies, we suggest that both, high and low levels of IGF-1 may be associated with poor cognitive function and that optimum levels of IGF-1 (quintile 2 and 3 in current study may be associated with better cognitive function.

  19. Predictors of mortality and short-term physical and cognitive dependence in critically ill persons 75 years and older: a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Ramakers Michel

    2011-05-01

    Full Text Available Abstract Background The purpose of this study was to identify predictors of 3-month mortality in critically ill older persons under medical care and to assess the clinical impact of an ICU stay on physical and cognitive dependence and subjective health status in survivors. Methods We conducted a prospective observational cohort study including all older persons 75 years and older consecutively admitted into ICU during a one-year period, except those admitted after cardiac arrest, All patients were followed for 3 months or until death. Comorbidities were assessed using the Charlson index and physical dependence was evaluated using the Katz index of Activity of Daily Living (ADL. Cognitive dependence was determined by a score based on the individual components of the Lawton index of Daily Living and subjective health status was evaluated using the Nottingham Health Profile (NHP score. Results One hundred patients were included in the analysis. The mean age was 79.3 ± 3.4 years. The median Charlson index was 6 [IQR, 4 to 7] and the mean ADL and cognitive scores were 5.4 ± 1.1 and 1.2 ± 1.4, respectively, corresponding to a population with a high level of comorbidities but low physical and cognitive dependence. Mortality was 61/100 (61% at 3 months. In multivariate analysis only comorbidities assessed by the Charlson index [Adjusted Odds Ratio, 1.6; 95% CI, 1.2-2.2; p p p = 0.04, and cognitive (p = 0.62 dependence in survivors had changed very little at 3 months. In addition, the mean NHP score was 213.1 ± 132.8 at 3 months, suggesting an acceptable perception of their quality of life. Conclusions In a selected population of non surgical patients 75 years and older, admission into the ICU is associated with a 3-month survival rate of 38% with little impact on physical and cognitive dependence and subjective health status. Nevertheless, a high comorbidity level (ie, Charlson index, multi-organ failure, and the need for extra-renal support at the

  20. Efficacy and safety of enzalutamide in patients 75 years or older with chemotherapy-naive metastatic castration-resistant prostate cancer

    DEFF Research Database (Denmark)

    Graff, J N; Baciarello, G; Armstrong, A J;

    2016-01-01

    .6-28.0); hazard ratio (HR) = 0.61 (95% CI 0.47-0.79); P = 0.0001], as was rPFS [not yet reached (95% CI 12.3-not yet reached) versus 3.7 months (95% CI 3.6-5.3); HR = 0.17 (95% CI 0.12-0.24); P ...BACKGROUND: Prostate cancer disproportionately affects older men. Because age affects treatment decisions, it is important to understand the efficacy and tolerability of therapies for advanced prostate cancer in elderly men. This analysis describes efficacy and safety outcomes in men aged ≥75 years...

  1. Onset and persistence of person-perceived participation restriction in older adults: a 3-year follow-up study in the general population

    Directory of Open Access Journals (Sweden)

    Peat George

    2008-11-01

    Full Text Available Abstract Background Participation restriction is defined as "problems an individual may experience in involvement in life situations" and refers to the personal and societal consequences of health conditions. There is a growing interest in participation restriction because (i problems with work or looking after others may be more concerning to individuals than the signs and symptoms of health conditions and (ii even when poor health persists, participation may still be maintained. The natural history of participation restriction in the general population is unknown and the aim of this report is to describe change in status of person-perceived participation restriction over three years in community-dwelling adults aged 50 years and over. Method Prospective cohort study (baseline and 3-year follow-up using postal questionnaires mailed to a population-based sample of older adults. Responders were included in this study if they completed all items of the Keele Assessment of Participation at baseline (n = 6965. Estimates of onset and persistence of person-perceived participation restriction at 3-year follow-up were calculated for any and for each aspect of life in the sample as a whole, and then by age and gender using attrition re-weighted logistic regression to take account of sample attrition. Results In the whole sample of 6965 persons, overall participation status at three years was unchanged in 69%, and changed in 31%. Of 3431 persons with no restriction at baseline, it is estimated that 29.8% (95% confidence interval: 27.6%, 32.0% would report restriction in at least one aspect of life at 3-year follow-up. Of 3534 persons who had baseline restriction, it is estimated that 68.8% (66.2%, 71.3% would report continuing restriction in at least one aspect of life after 3 years. Onset and persistence both increased with age, and were most frequently recorded for restricted mobility outside the home. Conclusion Although most older persons do not

  2. The Impact of Pituitary Blockage with GnRH Antagonist and Gonadotrophin Stimulation Length on The Outcome of ICSI Cycles in Women Older than 36 Years

    Directory of Open Access Journals (Sweden)

    Rosane Santana

    2014-07-01

    Full Text Available Background: The objective of this retrospective cohort study was to evaluate whether the length of pituitary blockage with gonadotrophin-releasing hormone (GnRH antagonists or the stimulation period influence intracytoplasmic sperm injection (ICSI outcomes in patients older than 36 years of age. Materials and Methods: In this retrospective study, a total of 138 couples with maternal age >36 years undergoing ICSI with an antagonist protocol were included. The influences of stimulation and suppression length on the response to ovarian stimulation and ICSI outcomes were investigated. Receiver operating characteristic curve (ROC analysis was performed to assess the predictive value of the stimulation period for achievement of implantation and pregnancy. Results: The gonadotrophin stimulation length negatively influenced the implantation rate (RC: -4.200; p=0.023. The area under ROC curve (AUC could distinguish between women with positive and negative implantation (AUC: 0.611; CI: 0.546-0.673 and pregnancy (AUC: 0.593; CI: 0.528-0.656. The threshold value demonstrated a high negative predictive value on likelihood of implantation (p=0.0032, 90% sensitivity and pregnancy (p=0.0147, 87.1% sensitivity when patients underwent more than 10 days of stimulation. Conclusion: The stimulation period negatively influences the implantation rate in women older than 36 years. A stimulation interval greater than 10 days is associated with a negative predictive value for the chance of implantation and pregnancy.

  3. Mortality from Unspecified Unintentional Injury among Individuals Aged 65 Years and Older by U.S. State, 1999–2013

    Directory of Open Access Journals (Sweden)

    Xunjie Cheng

    2016-07-01

    Full Text Available Introduction: Recent changes in unspecified unintentional injury mortality for the elderly by U.S. state remain unreported. This study aims to examine U.S. state variations in mortality from unspecified unintentional injury among Americans aged 65+, 1999–2013; Methods: Using mortality rates from the U.S. CDC’s Web-based Injury Statistics Query and Reporting System (WISQARS™, we examined unspecified unintentional injury mortality for older adults aged 65+ from 1999 to 2013 by state. Specifically, the proportion of unintentional injury deaths with unspecified external cause in the data was considered. Linear regression examined the statistical significance of changes in proportion of unspecified unintentional injury from 1999 to 2013; Results: Of the 36 U.S. states with stable mortality rates, over 8-fold differences were observed for both the mortality rates and the proportions of unspecified unintentional injury for Americans aged 65+ during 1999–2013. Twenty-nine of the 36 states showed reductions in the proportion of unspecified unintentional injury cause, with Oklahoma (−89%, Massachusetts (−86% and Oregon (−81% displaying the largest changes. As unspecified unintentional injury mortality decreased, mortality from falls in 28 states and poisoning in 3 states increased significantly. Mortality from suffocation in 15 states, motor vehicle traffic crashes in 12 states, and fire/burn in 8 states also decreased; Conclusions: The proportion of unintentional injuries among older adults with unspecified cause decreased significantly for many states in the United States from 1999 to 2013. The reduced proportion of unspecified injury has implications for research and practice. It should be considered in state-level trend analysis during 1999–2013. It also suggests comparisons between states for specific injury mortality should be conducted with caution, as large differences in unspecified injury mortality across states and over time

  4. ALMA imaging of gas and dust in a galaxy protocluster at redshift 5.3: [C II] emission in 'typical' galaxies and dusty starbursts ≈1 billion years after the big bang

    Energy Technology Data Exchange (ETDEWEB)

    Riechers, Dominik A. [Department of Astronomy, Cornell University, 220 Space Sciences Building, Ithaca, NY 14853 (United States); Carilli, Christopher L. [National Radio Astronomy Observatory, PO Box O, Socorro, NM 87801 (United States); Capak, Peter L.; Yan, Lin [Spitzer Science Center, California Institute of Technology, MC 220-6, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Scoville, Nicholas Z. [Astronomy Department, California Institute of Technology, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Smolčić, Vernesa [University of Zagreb, Physics Department, Bijenička cesta 32, 10002 Zagreb (Croatia); Schinnerer, Eva [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Yun, Min [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States); Cox, Pierre [ALMA Santiago Central Office, Alonso de Cordova 3107, Vitacura, Santiago (Chile); Bertoldi, Frank; Karim, Alexander, E-mail: dr@astro.cornell.edu [Argelander-Institut für Astronomie, Universität Bonn, Auf dem Hügel 71, Bonn, D-53121 (Germany)

    2014-12-01

    We report interferometric imaging of [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) and OH({sup 2}Π{sub 1/2} J = 3/2→1/2) emission toward the center of the galaxy protocluster associated with the z = 5.3 submillimeter galaxy (SMG) AzTEC-3, using the Atacama Large (sub)Millimeter Array (ALMA). We detect strong [C II], OH, and rest-frame 157.7 μm continuum emission toward the SMG. The [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) emission is distributed over a scale of 3.9 kpc, implying a dynamical mass of 9.7 × 10{sup 10} M {sub ☉}, and a star formation rate (SFR) surface density of Σ{sub SFR} = 530 M {sub ☉} yr{sup –1} kpc{sup –2}. This suggests that AzTEC-3 forms stars at Σ{sub SFR} approaching the Eddington limit for radiation pressure supported disks. We find that the OH emission is slightly blueshifted relative to the [C II] line, which may indicate a molecular outflow associated with the peak phase of the starburst. We also detect and dynamically resolve [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) emission over a scale of 7.5 kpc toward a triplet of Lyman-break galaxies with moderate UV-based SFRs in the protocluster at ∼95 kpc projected distance from the SMG. These galaxies are not detected in the continuum, suggesting far-infrared SFRs of <18-54 M {sub ☉} yr{sup –1}, consistent with a UV-based estimate of 22 M {sub ☉} yr{sup –1}. The spectral energy distribution of these galaxies is inconsistent with nearby spiral and starburst galaxies, but resembles those of dwarf galaxies. This is consistent with expectations for young starbursts without significant older stellar populations. This suggests that these galaxies are significantly metal-enriched, but not heavily dust-obscured, 'normal' star-forming galaxies at z > 5, showing that ALMA can detect the interstellar medium in 'typical' galaxies in the very early universe.

  5. Ubiquitous Supercritical Wing Design Cuts Billions in Fuel Costs

    Science.gov (United States)

    2015-01-01

    A Langley Research Center engineer’s work in the 1960s and ’70s to develop a wing with better performance near the speed of sound resulted in a significant increase in subsonic efficiency. The design was shared with industry. Today, Renton, Washington-based Boeing Commercial Airplanes, as well as most other plane manufacturers, apply it to all their aircraft, saving the airline industry billions of dollars in fuel every year.

  6. Smoking, Antioxidant Supplementation and Dietary Intakes among Older Adults with Age-Related Macular Degeneration over 10 Years

    OpenAIRE

    Gopinath, Bamini; Flood, Victoria M; Kifley, Annette; Liew, Gerald; Mitchell, Paul

    2015-01-01

    We aimed to compare the micronutrient usage and other lifestyle behaviors over 10 years among those with and without age-related macular degeneration (AMD). 1612 participants aged 49+ years at baseline were re-examined over 10 years, west of Sydney, Australia. AMD was assessed from retinal photographs. Dietary data were collected using a semi-quantitative food frequency questionnaire. Smoking status was self-reported. 56 participants had any AMD at baseline, of these 25% quit smoking at 5 yea...

  7. Associations of Sarcopenic Obesity and Dynapenic Obesity with Bone Mineral Density and Incident Fractures Over 5-10 Years in Community-Dwelling Older Adults.

    Science.gov (United States)

    Scott, David; Chandrasekara, Sahan D; Laslett, Laura L; Cicuttini, Flavia; Ebeling, Peter R; Jones, Graeme

    2016-07-01

    The purpose of this study is to determine whether low muscle mass (sarcopenia) or strength (dynapenia), in the presence of obesity, are associated with increased risk for osteoporosis and non-vertebral fracture over 5-10 years in community-dwelling older adults. N = 1089 volunteers (mean ± SD age 62 ± 7 years; 51 % female) participated at baseline and 761 attended follow-up clinics (mean 5.1 ± 0.5 years later). Total body, total hip and spine BMD, and appendicular lean and total fat mass were assessed by DXA. Sarcopenic obesity and dynapenic obesity were defined as the lowest sex-specific tertiles for appendicular lean mass or lower-limb strength, respectively, and the highest sex-specific tertile for total fat mass. Fractures were self-reported on three occasions over 10.7 ± 0.7 years in 563 participants. Obese alone participants had significantly higher BMD at all sites compared with non-sarcopenic non-obese. Sarcopenic obese and dynapenic obese men had lower spine and total body BMD, respectively, and sarcopenic obese women had lower total hip BMD, compared with obese alone (all P Sarcopenic obese men had higher non-vertebral fracture rates compared to non-sarcopenic non-obese (incidence rate ratio: 3.0; 95 % CI 1.7-5.5), and obese alone (3.6; 1.7-7.4). Sarcopenic obese women had higher fracture rates compared with obese alone (2.8; 1.4-5.6), but this was non-significant after adjustment for total hip BMD. Sarcopenic and dynapenic obese older adults may have increased risk of osteoporosis and non-vertebral fracture relative to obese alone counterparts. Sarcopenic and dynapenic obese individuals potentially represent a subset of the obese older adult population who require closer monitoring of bone health during ageing. PMID:26939775

  8. Evolution of vaccination rates after the implementation of a free systematic pneumococcal vaccination in Catalonian older adults: 4-years follow-up

    Directory of Open Access Journals (Sweden)

    Ansa Xabier

    2006-09-01

    Full Text Available Abstract Background The systematic vaccination with 23-valent polysaccharide pneumococcal vaccine (PPV was introduced as a strategic objective of health for all the people over 65 in Catalonia in 1999. We analysed the evolution of the pneumococcal vaccination rates from 2000 to 2003. Methods We conducted a retrospective population-based study including all the individuals 65 years or older assigned to 8 Primary Care Centres (PCCs in Tarragona (Catalonia, Spain, who figured in the administrative population databases on 31 December 2003 (n = 10,410 persons. We assessed whether every person had received PPV during the last four years (2000 to 2003 or whether they had received it before January 2000. Data sources were the computerised clinical records of the 8 participating PCCs, which included adult vaccination registries and diagnoses coded of International Classification of Diseases 9th Review Results The overall vaccination uptake increased to 38.6% at the end of 2000. Global accumulated coverages increased more slowly the following years: 44.4% in 2001, 50.9% in 2002, and 53.1% at the end of 2003. Vaccine uptake varied significantly according to age (46.7% in people 65–74 years-old, 60.9% in people 75 years or more; p Discussion The pneumococcal vaccination coverage increased quickly after the introduction of the recommendation for free vaccination in all the elderly people (with and without risk factors, but two years after the improvement the coverage became stable and increased slowly.

  9. Seven-year results of a press-fit, hydroxyapatite-coated double mobility acetabular component in patients aged 65 years or older.

    Science.gov (United States)

    Fresard, Pierre-Luc; Alvherne, Charles; Cartier, Jean-Loup; Cuinet, Patrick; Lantuejoul, Jean-Pierre

    2013-05-01

    One hundred and thirty-four THA were done between 1998 and 2002 with AVANTAGE(®) Press-Fit double mobility cup. The mean age of patients was 74 ± 6 years (range 65-94 years). The mean follow-up was 5.4 years (range, 0.15-10 years). The mean preoperative Harris Hip Score was 51.3 ± 14 versus 88 ± 12, at the latest follow-up, and the mean Merle d'Aubigné hip functional score was 8 ± 3 versus 16.3 ± 2.91; patients (68 %) were alive at a mean of 7.2 years postoperatively (range, 5-10 years). Three revisions were documented for aseptic loosening. The overall survival rate at 7.2 years was 96.3 % (95 % confidence interval 92.2-100) using cup revision for aseptic loosening as the end point. PMID:23412297

  10. Billion shot flashlamp for spaceborne lasers

    Science.gov (United States)

    Richter, Linda; Schuda, Felix; Degnan, John

    1990-01-01

    A billion-shot flashlamp developed under a NASA contract for spaceborne laser missions is presented. Lifetime-limiting mechanisms are identified and addressed. Two energy loadings of 15 and 44 Joules were selected for the initial accelerated life testing. A fluorescence-efficiency test station was used for measuring the useful-light output degradation of the lamps. The design characteristics meeting NASA specifications are outlined. Attention is focused on the physical properties of tungsten-matrix cathodes, the chemistry of dispenser cathodes, and anode degradation. It is reported that out of the total 83 lamps tested in the program, 4 lamps reached a billion shots and one lamp is beyond 1.7 billion shots, while at 44 Joules, 4 lamps went beyond 100 million shots and one lamp reached 500 million shots.

  11. Evaluating the effectiveness of a home-based exercise programme delivered through a tablet computer for preventing falls in older community-dwelling people over 2 years: study protocol for the Standing Tall randomised controlled trial

    OpenAIRE

    Delbaere, K.; T. Valenzuela; Woodbury, A.(?) (?); Davies, T.; Yeong, J; D. Steffens; Miles, L; Pickett, L; Zijlstra, G.A.R.; Clemson, L; Close, J C T; Howard, K; Lord, S. R.

    2015-01-01

    Introduction In order to prevent falls, older people should exercise for at least 2 h per week for 6 months, with a strong focus on balance exercises. This article describes the design of a randomised controlled trial to evaluate the effectiveness of a home-based exercise programme delivered through a tablet computer to prevent falls in older people. Methods and analysis Participants aged 70 years or older, living in the community in Sydney will be recruited and randomly allocated to an inter...

  12. First episode of self-harm in older age: a report from the 10-year prospective Manchester Self-Harm project

    NARCIS (Netherlands)

    Oude Voshaar, R.C.; Cooper, J.; Murphy, E.; Steeg, S.; Kapur, N.; Purandare, N.B.

    2011-01-01

    OBJECTIVE: Self-harm is closely related to completed suicide, especially in older age. As empirical research of self-harm in older age is scarce, with no studies confined to first-ever episodes in older age, we examined the clinical characteristics and the risk of repetition in first-ever self-harm

  13. First Episode of Self-Harm in Older Age : A Report From the 10-Year Prospective Manchester Self-Harm Project

    NARCIS (Netherlands)

    Voshaar, Richard C. Oude; Cooper, Jayne; Murphy, Elizabeth; Steeg, Sarah; Kapur, Nay; Purandare, Nitin B.

    2011-01-01

    Objective: Self-harm is closely related to completed suicide, especially in older age. As empirical research of self-harm in older age is scarce, with no studies confined to first-ever episodes in older age, we examined the clinical characteristics and the risk of repetition in first-ever self-harm

  14. Indicators of "Healthy Aging" in older women (65-69 years of age. A data-mining approach based on prediction of long-term survival

    Directory of Open Access Journals (Sweden)

    Swindell William R

    2010-08-01

    Full Text Available Abstract Background Prediction of long-term survival in healthy adults requires recognition of features that serve as early indicators of successful aging. The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF. Methods We considered only the youngest subjects (n = 4,097 enrolled in the SOF cohort (65 to 69 years of age and excluded older SOF subjects more likely to exhibit a "frail" phenotype. A total of 377 phenotypic measures were screened to determine which were of most value for prediction of long-term (19-year survival. Prognostic capacity of individual predictors, and combinations of predictors, was evaluated using a cross-validation criterion with prediction accuracy assessed according to time-specific AUC statistics. Results Visual contrast sensitivity score was among the top 5 individual predictors relative to all 377 variables evaluated (mean AUC = 0.570. A 13-variable model with strong predictive performance was generated using a forward search strategy (mean AUC = 0.673. Variables within this model included a measure of physical function, smoking and diabetes status, self-reported health, contrast sensitivity, and functional status indices reflecting cumulative number of daily living impairments (HR ≥ 0.879 or RH ≤ 1.131; P Conclusions The multivariate model we developed characterizes a "healthy aging" phenotype based upon an integration of measures that together reflect multiple dimensions of an aging adult (65-69 years of age. Age-sensitive components of this model may be of value as biomarkers in human studies that evaluate anti-aging interventions. Our methodology could be applied to data from other longitudinal cohorts to generalize these findings, identify additional predictors of long-term survival, and to further develop the "healthy aging" concept.

  15. Physical activity and all-cause mortality among older Brazilian adults: 11-year follow-up of the Bambuí Health and Aging Study

    Directory of Open Access Journals (Sweden)

    Ramalho JR

    2015-04-01

    Full Text Available Juciany RO Ramalho,1 Juliana VM Mambrini,1 Cibele C César,1,2 César M de Oliveira,3 Josélia OA Firmo,1 Maria Fernanda Lima-Costa,1 Sérgio V Peixoto1,4 1Rene Rachou Research Center, Oswaldo Cruz Foundation, 2Department of Statistics, Federal University of Minas Gerais, Belo Horizonte, Brazil; 3Research Department of Epidemiology and Public Health, University College London, London, UK; 4Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil Objective: To investigate the association between physical activity (eg, energy expenditure and survival over 11 years of follow-up in a large representative community sample of older Brazilian adults with a low level of education. Furthermore, we assessed sex as a potential effect modifier of this association.Materials and methods: A population-based prospective cohort study was conducted on all the ≥60-year-old residents in Bambuí city (Brazil. A total of 1,606 subjects (92.2% of the population enrolled, and 1,378 (85.8% were included in this study. Type, frequency, and duration of physical activity were assessed in the baseline survey questionnaire, and the metabolic equivalent task tertiles were estimated. The follow-up time was 11 years (1997–2007, and the end point was mortality. Deaths were reported by next of kin during the annual follow-up interview and ascertained through the Brazilian System of Information on Mortality, Brazilian Ministry of Health. Hazard ratios (95% confidence intervals [CIs] were estimated by Cox proportional-hazard models, and potential confounders were considered.Results: A statistically significant interaction (P<0.03 was found between sex and energy expenditure. Among older men, increases in levels of physical activity were associated with reduced mortality risk. The hazard ratios were 0.59 (95% CI 0.43–0.81 and 0.47 (95% CI 0.34–0.66 for the second and third tertiles, respectively. Among older women, there was no significant association

  16. Longitudinal Study of Performance on the Ruff Figural Fluency Test in Persons Aged 35 Years or Older

    OpenAIRE

    van Eersel, Marlise E. A.; Joosten, Hanneke; Koerts, Janneke; Gansevoort, Ron T.; Slaets, Joris P. J.; Izaks, Gerbrand J.

    2015-01-01

    The Ruff Figural Fluency Test (RFFT) is a cognitive test to measure executive function. Longitudinal studies have shown that repeated testing improves performance on the RFFT. Such a practice effect may hinder the interpretation of test results in a clinical setting. Therefore, we investigated the longitudinal performance on the RFFT in persons aged 35–82 years. Performance on the RFFT was measured three times over an average follow-up period of six years in 2,515 participants of the Preventi...

  17. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome

    OpenAIRE

    Faderl, Stefan; Ravandi, Farhad; Huang, Xuelin; Garcia-Manero, Guillermo; Ferrajoli, Alessandra; Estrov, Zeev; Borthakur, Gautam; Verstovsek, Srdan; Thomas, Deborah A.; Kwari, Monica; Kantarjian, Hagop M.

    2008-01-01

    We previously reported the feasibility of clofarabine and cytarabine combinations in AML. Questions remain as to (1) the therapeutic advantage of this combination and (2) the role of lower doses of clofarabine and cytarabine in older patients. We have conducted an adaptively randomized study of lower-dose clofarabine with or without low-dose cytarabine in previously untreated patients with AML aged 60 years and older. Patients received 30 mg/m2 clofarabine intravenously daily for 5 days with ...

  18. Obesity Prevention in Older Adults.

    Science.gov (United States)

    Volpe, Stella Lucia; Sukumar, Deeptha; Milliron, Brandy-Joe

    2016-06-01

    The number of older adults living in the USA, 65 years of age and older, has been steadily increasing. Data from the National Health and Nutrition Examination Survey (NHANES), 2007-2010, indicate that more than one-third of older adults, 65 years of age and older, were obese. With the increased rate of obesity in older adults, the purpose of this paper is to present research on different methods to prevent or manage obesity in older adults, namely dietary interventions, physical activity interventions, and a combination of dietary and physical activity interventions. In addition, research on community assistance programs in the prevention of obesity with aging will be discussed. Finally, data on federal programs for older adults will also be presented. PMID:27107762

  19. Alcohol Use among Abused and Non-Abused Older Persons Aged 60-84 Years: An European Study

    Science.gov (United States)

    Tredal, Ingrid; Soares, Joaquim J. F.; Sundin, Orjan; Viitasara, Eija; Melchiorre, Maria Gabriella; Torres-Gonzales, Francisco; Stankunas, Mindaugas; Lindert, Jutta; Ioannidi-Kapolou, Elisabeth; Barros, Henrique

    2013-01-01

    Aims: Describing alcohol use by abuse type (e.g. psychological) and considering other factors (e.g. depression). Methods: The respondents were 4467 (2559 women, 57.3%) randomly selected elders (60-84 years) from seven European cities. The cross-sectional data were collected with scales covering various areas and examined with…

  20. Postoperative morbidity and discharge destinations after fast-track hip and knee arthroplasty in patients older than 85 years

    DEFF Research Database (Denmark)

    Pitter, Frederik T; Jørgensen, Christoffer C; Lindberg-Larsen, Martin; Kehlet, Henrik

    2016-01-01

    study was to provide detailed information on postoperative morbidity resulting in LOS >4 days or readmissions <90 days after fast-track THA and TKA in patients ≥85 years. METHODS: This is a descriptive, observational study in consecutive unselected patients ≥85 years undergoing fast-track THA/TKA. The...... primary outcome was the causes of postoperative morbidity leading to an LOS of >4 days. Secondary outcomes were 90-day surgically related readmissions, discharge destination, 90-day mortality, and role of disposing factors for LOS >4 days and 90-day readmissions. Data on preoperative characteristics were.......3% procedures, LOS was >4 days, with 82.7% due to medical causes, most often related to anemia requiring blood transfusion and mobilization issues. Use of walking aids was associated with LOS >4 days (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.26-3.15; P = 0.003), whereas preoperative anemia showed...

  1. Prevalence and type distribution of human papillomavirus among women older than 18 years in Egypt: a multicenter, observational study

    OpenAIRE

    Mohamed Fadel Shaltout; Sallam, Hassan N.; Maged AbouSeeda; Fady Moiety; Hossam Hemeda; Ahmed Ibrahim; Moutaz E.L. Sherbini; Helmy Rady; Kusuma Gopala; Rodrigo DeAntonio

    2014-01-01

    Objectives: Persistent infection with high-risk (HR) human papillomavirus (HPV) is associated with premalignant lesions and cervical cancer, the third most common cancer amongst women globally and the second most frequent in Egypt. We studied the prevalence and type distribution of HPV and documented HPV infection awareness and health-related behaviours for HPV infection. Methods: This was a multicenter, hospital-based observational study of women ≥18 years of age who attended for a gynaec...

  2. Association between mild cognitive impairment and cerebral vasoreactivity documented by transcranial Doppler in subjects older than 60 years.

    OpenAIRE

    Garza-Villarreal, Eduardo A.

    2014-01-01

    INTRODUCTION: Identifying Mild Cognitive Impairment (MCI) allows us to start treatment to delay or modify the course of the dementiasyndrome and can find new diagnostic tools and therapeutic monitoring.OBJECTIVE: The aim of this study was to determine the association of demographic, clinical and laboratory alterations in cerebral vasoreactivity measured by transcranial Doppler sonography in the population of subjects aged 60 years and its possible association with the DCL.MATERIAL AND METHODS...

  3. Billion silicon-disc markets in solar cells

    International Nuclear Information System (INIS)

    The generation of solar power is estimated to increase ten times higher than it is at present. The nominal power is estimated to be 150 MW by the year 2010. The capacity of a solar cell (100 cm2; efficiency 15%) is 1.5W under good illumination conditions. So the growth estimate, given by the Swiss Saras Bank, requires the processing of over one billion silicon discs in ten years to pn-junction solar cells. The researches, carried out at Helsinki University of Technology and VTT Electronics are presented in the article

  4. Spherule Beds 3.47-3.24 Billion Years Old in the Barberton Greenstone Belt, South Africa: A Record of Large Meteorite Impacts and Their Influence on Early Crustal and Biological Evolution

    Science.gov (United States)

    Lowe, Donald R.; Byerly, Gary R.; Kyte, Frank T.; Shukolyukov, Alexander; Asaro, Frank; Krull, Alexander

    2003-01-01

    Four layers, S1-S4, containing sand-sized spherical particles formed as a result of large meteorite impacts, occur in 3.47-3.24 Ga rocks of the Barberton Greenstone Belt, South Africa. Ir levels in S3 and S4 locally equal or exceed chondritic values but in other sections are at or only slightly above background. Most spherules are inferred to have formed by condensation of impact-produced rock vapor clouds, although some may represent ballistically ejected liquid droplets. Extreme Ir abundances and heterogeneity may reflect element fractionation during spherule formation, hydraulic fractionation during deposition, and/or diagenetic and metasomatic processes. Deposition of S1, S2, and S3 was widely influenced by waves and/or currents interpreted to represent impact-generated tsunamis, and S1 and S2 show multiple graded layers indicating the passage of two or more wave trains. These tsunamis may have promoted mixing within a globally stratified ocean, enriching surface waters in nutrients for biological communities. S2 and S3 mark the transition from the 300-million-year-long Onverwacht stage of predominantly basaltic and komatiitic volcanism to the late orogenic stage of greenstone belt evolution, suggesting that regional and possibly global tectonic reorganization resulted from these large impacts. These beds provide the oldest known direct record of terrestrial impacts and an opportunity to explore their influence on early life, crust, ocean, and atmosphere. The apparent presence of impact clusters at 3.26-3.24 Ga and approx. 2.65-2.5 Ga suggests either spikes in impact rates during the Archean or that the entire Archean was characterized by terrestrial impact rates above those currently estimated from the lunar cratering record.

  5. Comparison of Clinicopathological Features and Treatments between Young (≤40 Years and Older (>40 Years Female Breast Cancer Patients in West China: A Retrospective, Epidemiological, Multicenter, Case Only Study.

    Directory of Open Access Journals (Sweden)

    Ke Wang

    Full Text Available The incidence of young cases of breast cancer is higher in China compared to the western world. We aimed to explore differences in risk factors, clinicopathological features and treatment modes of young female breast cancer compared to older patients in West China. We collected clinical information from 12,209 female breast cancer patients in West China, including risk factors, clinicopathological features and treatment modes, from January 2010 to December 2012. Chi-square tests and the multivariate logistic regression analysis were applied for statistical analysis. There were 2,682 young (≤40 years cases and 9,527 older cases at the time of breast cancer diagnosis. Young patients had a greater tumor diameter at diagnosis, and a higher probability of axillary lymph node and distant metastasis (P 40 years female breast cancer patients in West China. As some of these results differ from those found in the western female population, it is likely that the mechanism of tumorigenesis of young female breast cancer patients in West China may differ from that in western developed countries. Further investigation into the regional differences in breast cancer tumorigenesis is warranted.

  6. Urodynamics in a community-dwelling population of females 80 years or older: which motive? Which diagnosis?

    Directory of Open Access Journals (Sweden)

    Françoise A. Valentini

    2010-04-01

    Full Text Available PURPOSE: To determine why community-dwelling women aged 80 years or over were referred for urodynamic evaluation despite their advanced age and which urodynamic diagnosis was made. MATERIALS AND METHODS: One hundred consecutive females (80-93 years were referred to our urodynamics outpatient clinic for evaluation of lower urinary tract symptoms (LUTS between 2005 and 2008. Clinical evaluation comprised of a previous history of LUTS, previous medical history of neurological disease or dementia, pelvic floor dysfunction or prior pelvic surgery. Exclusion criteria were complete retention and severe dementia involving failure to understand simple instructions. Assessed items were results of uroflows (free flow and intubated flow, cystometry and urethral pressure profilometry, and final urodynamic diagnosis. RESULTS: The main complaint evoked by the patients was incontinence (65.0% of which 61.5% was "complicated" and urgency was reported by 70.0%. Interpretable free flow at arrival was very low (44.0%. Prevalence of detrusor overactivity was high, found in 45 patients of whom 16 had detrusor hyperactivity with impaired detrusor contractility. Detrusor overactivity and urgency were strongly associated (p = 0.004. Twenty-five patients had intrinsic sphincteric deficiency alone and 15 detrusor underactivity. CONCLUSION: In this particular community-dwelling with an elderly female population, urodynamics is easily feasible. Incontinence, mainly "complicated" is the more frequent complaint and urgency the more frequent symptom. Urodynamic diagnosis underlines the high incidence of detrusor overactivity as well as impaired detrusor function.

  7. [A case of Plummer disease that appeared in older old age after 10-year course of subclinical hyperthyroidism].

    Science.gov (United States)

    Hasegawa, Takashi; Araki, Atsushi; Tamura, Yoshiaki; Sugawara, Tomoki; Iwata, Akiko; Kamimiya, Fumi; Chiba, Yuko; Horiuchi, Toshiyuki; Mori, Seijiro; Ito, Hideki

    2007-03-01

    A 81-year-old woman with a thyroid tumor and subclinical hyperthyroidism since ten years ago was admitted to our hospital for palpitations and hyperthyroidism (FT(4) 1.75 ng/dl, FT(3) 5.37 pg/ml, TSHantibody (TSAb) was transiently and mildly positive, anti-TSH receptor antibody (TRAb), microsome test, and thyroid test were negative. Thyroid echogram showed an isoechoic nodule in the left lobe (33 x 42 x 22 mm) and a small nodule (10 x 15 x 9 mm) in right lobe. Thyroid scintiscan showed a hyperfunctional (hot) nodule in left thyroid lobe with suppressed uptake in the remainder of the gland. The uptake rate of thyroidal radioiodine ((123)I) in 24 hours was within the normal range (7.3%). Based on the above findings, a diagnosis of Plummer disease was made. Since she refused invasive surgical or radioiodine treatment, she was treated with 10 mg thiamazole daily. After treatment with propranolol and thiamazole, the thyrotoxic symptoms disappeared and thyroid function returned to normal level. She had osteoporosis but she had neither atrial fibrillation nor cardiac symptoms. This was a rare case of Plummer disease that appeared in extremely old age after a long course of subclinical hyperthyroidism. PMID:17527029

  8. Somatic parameters of 17 year old soccer players in the older youth category in relation to sports performance

    Directory of Open Access Journals (Sweden)

    Petr Kutáč

    2013-09-01

    Full Text Available BACKGROUND: Somatic parameters are included not only in the general structure of sporting performance, but also in the structure of sporting performance in soccer. In light of this structure, higher performance players should have better somatic performance prerequisites, and their somatic parameters should differ from players with lower performance levels. OBJECTIVE: The aim of the study is to assess the somatic parameters of players with different performance levels. METHODS: The research included 90 soccer players in the age of 17 years in three performance categories playing in the junior competition in the Czech Republic. Average age of the individual levels – highest performance 17.61 ± 0.48, middle performance 17.50 ± 0.50, lowest performance 17.50 ± 0.50 years. The following was monitored – basic anthropometric parameters (body weight, body height, somatotype (Heath-Carter, representation of body fat (BF, fat free mass (FFM and the total body water (TBW. The Tanita 418 MA tetrapolar bioelectrical impedance (BIA scale was used for the determination of the representation of BF and the TBW. All players were measured at the beginning of the competition period in the same year. All measurements were implemented in the morning hours by the same person with corresponding experience. RESULTS: The average values of somatic parameters measured in the individual performance categories show that we can only consider them to be an indicator of sporting performance up to a particular performance level. The boundary was the middle performance level (teams playing regional competition as their mean values of the monitored somatic parameters significantly differed from the mean values of players at the lowest performance level (teams playing at the district and municipal levels but they did not differ when compared with the mean values of the players at the highest performance level (teams playing the top junior league. CONCLUSIONS

  9. Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study

    Directory of Open Access Journals (Sweden)

    Francine Hehn de Oliveira

    2015-07-01

    Full Text Available With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases by years. The tau protein is particularly interesting: it might be found in the brainstem and olfactory bulb long before it reaches the limbic cortex, at which point symptoms occur. Of the 14 brains collected in this study, the tau protein was found in the brainstems of 10 (71.42% and in olfactory bulbs of 3 out 11. Of the 7 individuals who had a final diagnosis of Alzheimer’s disease (AD, 6 presented tau deposits in some region of the brainstem. Our data support the idea of the presence of tau protein in the brainstem and olfactory bulb in the earliest stages of AD.

  10. The effects of pharmacist intervention on emergency department visits in patients 80 years and older: subgroup analyses by number of prescribed drugs and appropriate prescribing.

    Directory of Open Access Journals (Sweden)

    Anna Alassaad

    Full Text Available Clinical pharmacist interventions have been shown to have positive effect on occurrence of drug-related issues as well as on clinical outcomes. However, evidence about which patients benefiting most from the interventions is limited. We aimed to explore whether pharmacist intervention is equally effective in preventing emergency department (ED visits in patients with few or many prescribed drugs and in those with different levels of inappropriate prescribing.Patient and outcome data from a randomized controlled trial exploring the clinical effects of a ward-based pharmacist intervention in patients, 80 years and older, were used. The patients were divided into subgroups according to the number of prescribed drugs (<5 or ≥5 drugs and the level of inappropriate prescribing [using the Screening Tool Of Older People's potentially inappropriate Prescriptions (STOPP and the Screening Tool to Alert doctors to Right Treatment (START with a score of ≥2 (STOPP and ≥1 (START as cutoff points]. The effect of the intervention on the number of times the different subgroups visited the ED was analyzed.The pharmacist intervention was more effective with respect to the number of subsequent ED visits in patients taking <5 drugs on admission than in those taking ≥5 drugs. The rate ratio (RR for a subsequent ED visit was 0.22 [95% confidence interval (CI 0.09-0.52] for <5 drugs and 0.70 (95% CI 0.47-1.04 for ≥5 drugs (p = 0.02 for the interaction. The effect of intervention did not differ between patients with high or low STOPP or START scores.In this exploratory study, the pharmacist intervention appeared to be more effective in preventing visits to the ED for patients who were taking fewer drugs before the intervention. Our analysis of STOPP and START scores indicated that the level of inappropriate prescribing on admission had no effect on the outcomes of intervention with respect to ED visits.

  11. Factors Predicting Patient Dissatisfaction 2 Years After Discectomy for Lumbar Disc Herniation in a Chinese Older Cohort: A Prospective Study of 843 Cases at a Single Institution.

    Science.gov (United States)

    Wang, Hui; Zhang, Di; Ma, Lei; Shen, Yong; Ding, Wenyuan

    2015-10-01

    We aim to identify factors predicting patient dissatisfaction 2 years after discectomy for lumbar disc herniation (LDH) in a Chinese older cohort. Preoperative and 2-year follow-up data for 843 patients were analyzed. After 2 years of discectomy, the patients rated their satisfaction by Patient Satisfaction Index (PSI), with response of 1 or 2 defining satisfaction and a PSI response of 3 or 4 defining dissatisfaction. Associations between perioperative variables and satisfaction with the results of surgery were examined in univariate and multivariate analysis. Six hundred fifty-seven patients had a PSI of 1 or 2 and were enrolled as satisfied group, 186 patients had a PSI of 3 or 4 and were enrolled as dissatisfied group. At baseline, no significant differences were found between the 2 groups in age, occupation, Oswestry Disability Index (ODI), Visual Analog Scale (VAS)-leg, and VAS-back. Compared to satisfied group, dissatisfied group had a significantly higher BMI and a higher incidence of depression. Two years after discectomy, no significant differences were found between the 2 groups in decrease of ODI, decrease of VAS-back, decrease of VAS-leg, surgery complications. Compared to satisfied group, dissatisfied group experienced higher incidence of symptom recurrence and depression. Logistic regression analysis showed that obesity, pre- and postoperative depression, symptom recurrence were independently associated with patient dissatisfaction 2 years after discectomy.I n conclusion, more than 70% patients expressed satisfaction with discectomy for LDH. Two factors could predict patient dissatisfaction and be assessed before surgery: obesity and preoperative depression. Symptom recurrence and postoperative depression are also associated with diminished patient satisfaction. PMID:26448005

  12. Four billion people facing severe water scarcity

    OpenAIRE

    Mesfin M. Mekonnen; Arjen Y. Hoekstra

    2016-01-01

    Freshwater scarcity is increasingly perceived as a global systemic risk. Previous global water scarcity assessments, measuring water scarcity annually, have underestimated experienced water scarcity by failing to capture the seasonal fluctuations in water consumption and availability. We assess blue water scarcity globally at a high spatial resolution on a monthly basis. We find that two-thirds of the global population (4.0 billion people) live under conditions of severe water scarcity at lea...

  13. A review of the evidence to inform pneumococcal vaccine recommendations for risk groups aged 2 years and older.

    Science.gov (United States)

    Steens, A; Vestrheim, D F; Aaberge, I S; Wiklund, B S; Storsaeter, J; Riise Bergsaker, M A; Rønning, K; Furuseth, E

    2014-12-01

    For decades, vaccination with the 23-valent polysaccharide pneumococcal vaccine (PPV23) has been available for risk groups aged ⩾2 years to prevent invasive pneumococcal disease (IPD). Recently, a 13-valent pneumococcal conjugated vaccine (PCV13) has been licensed for use in all age groups. PCV13 may induce better protection than PPV23 because of different immunogenic properties. This called for a revision of vaccine recommendations for risk groups. We therefore reviewed literature on risk groups for IPD, and effectiveness and safety of pneumococcal vaccines and supplemented that with information from public health institutes, expert consultations and data on IPD epidemiology. We included 187 articles. We discuss the implications of the heterogenic vulnerability for IPD within and between risk groups, large indirect effects of childhood immunization, and limited knowledge on additional clinical benefits of PCV13 in combination with PPV23 for the Norwegian recommendations. These are now step-wise and consider the need for vaccination, choice of pneumococcal vaccines, and re-vaccination interval by risk group. PMID:24932959

  14. Incidence and predictors of asymptomatic atrial fibrillation in patients older than 70 years with complete atrioventricular block and dual chamber pacemaker implantation.

    LENUS (Irish Health Repository)

    Radeljic, Vjekoslav

    2012-01-31

    AIM: To evaluate predictors of asymptomatic atrial fibrillation in patients older than 70 years with complete atrioventricular (AV) block, normal left ventricular systolic function, and implanted dual chamber (DDD) pacemaker. METHODS: Hundred and eighty six patients with complete AV block were admitted over one year to the Sisters of Mercy University Hospital. The study recruited patients older than 70 years, with no history of atrial fibrillation, heart failure, or reduced left ventricular systolic function. All the patients were implanted with the same pacemaker. Out of 103 patients who were eligible for the study, 81 (78%) were evaluated. Among those 81 (78%) were evaluated. Eighty one (78%) patients were evaluated. Follow-up time ranged from 12 to 33 months (average +\\/-standard deviation 23 +\\/- 5 months). Primary end-point was asymptomatic atrial fibrillation occurrence recorded by the pacemaker. Atrial fibrillation occurrence was defined as atrial high rate episodes (AHRE) lasting >5 minutes. Binary logistic regression was used to identify the predictors of development of asymptomatic atrial fibrillation. Results. The 81 patients were stratified into two groups depending on the presence of AHRE lasting >5 minutes (group 1 had AHRE>5 minutes and group 2 AHRE<5 minutes). AHRE lasting >5 minutes were detected in 49 (60%) patients after 3 months and in 53 (65%) patients after 18 moths. After 3 months, only hypertension (odds ratio [OR], 17.63; P = 0.020) was identified as a predictor of asymptomatic atrial fibrillation. After 18 months, hypertension (OR, 14.0; P = 0.036), P wave duration >100 ms in 12 lead ECG (OR, 16.5; P = 0.001), and intracardial atrial electrogram signal amplitude >4 mV (OR, 4.27; P = 0.045) were identified as predictors of atrial fibrillation. CONCLUSION: In our study population, hypertension was the most robust and constant predictor of asymptomatic atrial fibrillation after 3 months, while P wave duration >100 ms in 12-lead ECG and

  15. No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008 aging seven years and older

    Directory of Open Access Journals (Sweden)

    Van Muylem Patrick

    2010-05-01

    Full Text Available Abstract Background The bovine spongiform encephalopathy (BSE epidemic presented homogeneity of the phenotype. This classical BSE (called C-type was probably due to the contamination of the food chain by a single prion strain. However, due to the active surveillance and better techniques, two rare variants of BSE have been recently reported in different continents without a clear correlation to the BSE epidemic. These emerging types behave as different strains of BSE and were named H-type and L-type according to the high and low molecular mass of the unglycosylated fragment of their proteinase K resistant prion protein (PrPres. In these types, the proportion of the un-, mono- and di-glycosylated fragments of PrP (glycoprofile is also atypical and represents an effective diagnostic parameter. This study evaluated the presence of such types in bovine of 7 years and older in Belgium. Results The Belgian BSE archive contained 41 bovines of at least 7 years of age. The biochemical features of their PrPres were analyzed by Western blot with five antibodies recognising different regions of PrPres, from N- to C-terminus: 12B2, 9A2, Sha31, SAF84 and 94B4. All antibodies clearly detected PrPres except 12B2 antibody, which is specific for N-terminal region 101-105, a PrP region that is only retained in H-types. The glycoprofiles did correspond to that of C-type (with more than 55% of diglycosylated PrPres using antibody 94B4. Therefore, all cases have the features of C-type BSE. Conclusions This study supports that, among the BSE cases of 7 years and older identified in Belgium, none was apparently of the H- or L- type. This is consistent with the very rare occurrence of atypical BSE and the restricted dimension of Belgium. These results shed some light on the worldwide prevalence of atypical BSE.

  16. The association between orthostatic hypotension and cognitive state among adults 65 years and older who underwent a comprehensive geriatric assessment.

    Science.gov (United States)

    Punchick, Boris; Freud, Tamar; Press, Yan

    2016-07-01

    The prevalence of cognitive impairment and orthostatic hypotension (OH) increases with age, but the results of studies that assessed possible associations between them are inconsistent.The aim of this study is to assess possible associations between cognitive impairment and OH in patients ≥65 years of age who underwent a comprehensive geriatric assessment.A retrospective analysis was conducted of the computerized medical records of the study population from 2005 to 2013. Data collected included blood pressure measurements that enabled the calculation of OH, results of the mini-mental state examination (MMSE), results of the Montreal cognitive assessment (MoCA) test, and cognitive diagnoses that were determined over the course of the assessment.The rate of OH in the study population of 571 adults was 32.1%. The mean MMSE score was 22.5 ± 5.2 among participants with OH and 21.6 ± 5.8 among those without OH (P = 0.09). The absence of a significant association between OH and MMSE remained after adjusting the MMSE score for age and education level. The mean MoCA score was 16.4 ± 5.0 among participants with OH and 16.4 ± 4.8 among those without (P = 0.33). The prevalence of OH was 39% among participants without cognitive impairment, 28.9% among those with mild cognitive impairment (MCI), and 30.6% among those with dementia (P = 0.13).There was no association between OH and cognitive impairment in adults who underwent a comprehensive geriatric assessment. PMID:27442658

  17. Galaxy Evolution Over the Past Eleven Billion Years

    DEFF Research Database (Denmark)

    Man, Wing Shan

    Galaxy evolution studies have been revolutionized by the advent of near-infrared observations over the last decade. An intriguingly population of distant red galaxies, only visible at near-infrared wavelengths, was discovered. They were previously overlooked, since they are invisible even in the...... deepest Hubble Space Telescope (HST) optical surveys. Their stellar populations, characterized using deep near-infrared photometric and spectroscopic observations, reveal that they are the most massive and evolved galaxies at early epochs. This suggests that they have undergone a rapid build-up of stellar...... mass followed by a short-lived, effective phase of star formation quenching. Curiously, their stellar densities are an order of magnitude higher than their local counterparts, containing 1011 solar masses within a radius of only 1.5 kpc. No similar galaxies exist in the local Universe, therefore they...

  18. The First Billion Years of a Warm Dark Matter Universe

    CERN Document Server

    Maio, Umberto

    2014-01-01

    We present results of cosmological N-body hydrodynamic chemistry simulations of primordial structure growth and evolution in a scenario with warm dark matter (WDM) having a mass of 3keV and compare with a model consisting of standard cold dark matter (CDM). We focus on the high-redshift universe ($z>6$), where the structure formation process should better reflect the primordial (linear) differences in terms of matter power spectrum. We find that early epochs are exceptional probes of the dark-matter nature. Non-linear CDM and WDM power spectra differ by up to 2 dex at early times and show spreads of factor of a few persisting in the whole first Gyr. Primordial WDM objects with masses $\\lesssim 10^8\\,\\rm M_\\odot$ are less abundant by $\\gtrsim 1\\,\\rm dex$, both in terms of dark matter and of baryon content. Runaway molecular cooling in primordial WDM mini-haloes results severely inhibited due to the damping of power at large $k$ modes. As a consequence, the cosmic (population III and II-I) star formation activi...

  19. Two-billion-year-old nuclear reactors: Nature goes fission

    International Nuclear Information System (INIS)

    Once it was thought that the isotopic composition of natural uranium was invariant. It was thus surprising in 1972 when French scientists observed small but significant deficiencies of the minor isotope 235U in uranium ore. Subsequent investigations traced the isotopically anomalous material to the Oklo mine in the African Republic of Gabon. In the mine, cubic-dekametre-sized pods of rock were found to contain extraordinary concentrations of uranium, as much as 65%, with as little as half the normal isotopic abundance of 235U. In these rocks, neodymium was found to be deficient in the premordial isotope 142Nd and enriched in the fission-produced isotopes 143-150Nd. The presence of fission products was unambiguous evidence that the 235U deficiencies were the result of sustained nuclear fission. Within the heart of the natural reactors, the fission densities were on the order of 1020 fissions/cm3, producing hundreds of megajoules of energy and tens of microwatts of power per gram of rock. Nature had forestalled man's great discovery of energy production by nuclear fission

  20. Social Networks and Memory over 15 Years of Followup in a Cohort of Older Australians: Results from the Australian Longitudinal Study of Ageing

    Directory of Open Access Journals (Sweden)

    Lynne C. Giles

    2012-01-01

    Full Text Available The purpose was to examine the relationship between different types of social networks and memory over 15 years of followup in a large cohort of older Australians who were cognitively intact at study baseline. Our specific aims were to investigate whether social networks were associated with memory, determine if different types of social networks had different relationships with memory, and examine if changes in memory over time differed according to types of social networks. We used five waves of data from the Australian Longitudinal Study of Ageing, and followed 706 participants with an average age of 78.6 years (SD 5.7 at baseline. The relationships between five types of social networks and changes in memory were assessed. The results suggested a gradient of effect; participants in the upper tertile of friends or overall social networks had better memory scores than those in the mid tertile, who in turn had better memory scores than participants in the lower tertile. There was evidence of a linear, but not quadratic, effect of time on memory, and an interaction between friends’ social networks and time was apparent. Findings are discussed with respect to mechanisms that might explain the observed relationships between social networks and memory.

  1. Sensory impairment in hip-fracture patients 65 years or older and effects of hearing/vision interventions on fall frequency

    Directory of Open Access Journals (Sweden)

    Else V Grue

    2008-11-01

    Full Text Available Else V Grue1, Marit Kirkevold2, Petter Mowinchel3, Anette H Ranhoff41Diakonhjemmet University College, Department of Research and Development, Oslo, Norway; 2University of Oslo, Department of Medisin, Institute of Nursing Sciences and Health Profession, Oslo, Norway; 3Department of Paediatrics, Woman-child division, Ullevål University Hospital Oslo, Norway; 4Diakonhjemmet Hospital, Geriatric Unit, Oslo, NorwayAim: Examine the effect of nursing interventions to improve vision and hearing, systematic assessment, and referral to sensory specialists on falling.Methods: Controlled intervention trial targeting hip fracture patients, 65 years and older, living at home and having problems seeing/reading regular print (VI or hearing normal speech (HI. Intervention group = 200, control group = 131. The InterRAI-AcuteCare (RAI-AC and the Combined-Serious-Sensory-Impairment interview guide (KAS-Screen were used. Follow-up telephone calls were done every third month for one year.Results: Mean age was 84.2 years, 79.8% were female, and 76.7% lived alone. HI was detected in 80.7% and VI in 59.8%. Falling was more frequent among the intervention group (P = 0.003 and they also more often moved to a nursing home (P < 0.001 and were dependent walking up stairs (P = 0.003.Conclusions: This study could not document the effect of intervention on falling, possibly because of different base line characteristics (more females, P = 0.018, and more living alone P = 0.011 in the intervention group, differences in nursing care between subjects, and different risk factors. Interventions to improve sensory function remain important in rehabilitation, but have to be studied further.Keywords: vision, hearing, hip fracture, falls, intervention, hospital

  2. The geography of diabetes among the general adults aged 35 years and older in Bangladesh: recent evidence from a cross-sectional survey.

    Directory of Open Access Journals (Sweden)

    Md Mobarak Hossain Khan

    Full Text Available OBJECTIVE: To report geographical variations of sex-specific diabetes by place of residence (large cities/city corporations, small towns/other urban areas, rural areas and region of residence (divided into seven divisions among general adults (35+ years of age in Bangladesh. METHODS: The recent cross-sectional data, extracted from the nationally representative Bangladesh Demographic and Health Survey 2011, was used. A total of 3,720 men and 3,823 women aged 35+ years, who participated in the fasting blood sugar testing, were analysed. Any person with either fasting plasma glucose level (mmol/L ≥7.0 or taking medication for diabetes was considered as a person with diabetes. RESULTS: The prevalence of diabetes was 10.6% in men and 11.3% in women. Bivariable analyses indicated significant variations of diabetes by both geographical variables. The prevalence was highest in city corporations (men 18.0%, women 22.3%, followed by small towns (men 13.6%, women 15.2% and rural areas (men 9.3%, women 9.5%. Regional disparities in diabetes prevalence were also remarkable, with the highest prevalence in Chittagong division and lowest prevalence in Khulna division. Multivariable logistic regression analyses provided mixed patterns of geographical disparities (depending on the adjusted variables. Some other independent risk factors for diabetes were advancing age, higher level of education and wealth, having TV (a proxy indicator of physical activity, overweight/obesity and hypertension. CONCLUSIONS: Over 10% of the general adults aged 35 years and older were having diabetes. Most of the persons with diabetes were unaware of this before testing fasting plasma glucose level. Although significant disparities in diabetes prevalence by geographical variables were observed, such disparities are very much influenced by the adjusted variables. Finally, we underscore the necessities of area-specific strategies including early diagnosis and health education

  3. TOU' rates hold out $13-billion prize

    Energy Technology Data Exchange (ETDEWEB)

    Slaboszewicz, C.

    1994-03-15

    By 2000, U.S. electric utilities will add 90,000 MW of generating capacity to meet peaking needs. Rather than spend $45 billion on these power plants, which will be used only a couple of hundred hours each year, electric utilities could use incentive pricing-residential time-of-use (TOU) rates-to save consumers up to $13 billion. The combination of market forces and new technology to support automatic meter reading and other applications makes these savings not only possible but practical. Unlike prices at other capacity-constrained industries such as airlines or telephone companies, electric utility prices usually do not vary by time of day. The result is average capacity factors of 43.8 percent (based on 1989 data), compared to a U.S. airlines average of 63.2 percent. Significantly, the airline average use to be below 50 percent in 1970, when they, like electric utilities, were closely regulated. Through incentive pricing, airlines were able to achieve almost a 30-percent increase in efficiency. According to studies by the Electric Power Research Institute (EPRI) and Edison Electric Institute (EEI), TOU pricing could increase the efficiency of U.S. power plant use by nearly 15 percent. Power plant needs for the next seven years offer an excellent opportunity to use TOU pricing to save consumers billions of dollars. According to Burns McDonnell, an engineering firm, new electric generation resources will not be needed before the turn of the century to prevent to projected deficit of peaking capacity. Indeed, Burns McDonnell estimates a current excess of 152,000 MW in nation-wide baseload capacity. TOU pricing, according to EPRI and EEI, causes residential consumers to reduce their onpeak electricity consumption by 20 percent. With a residential peak load of 183,000 MW, this reduction translates into over 36,000 MW of capacity.

  4. Association between the metabolic syndrome and its components and gait speed among U.S. adults aged 50 years and older: a cross-sectional analysis

    Directory of Open Access Journals (Sweden)

    Strine Tara W

    2006-11-01

    Full Text Available Abstract Background To examine the relationship between the metabolic syndrome and its components and gait speed among older U.S. men and women. Whether these associations are independent of physical activity was also explored. Methods Eight hundred and thirty-five men and 850 women aged ≥50 years from the continuous National Health and Nutrition Examination Survey 1999–2002 were examined. We used the definition of the metabolic syndrome developed by the U.S. National Cholesterol Education Program Adult Treatment Panel III. Gait speed was measured with a 6.10-meter timed walk examination. Results The prevalence of the metabolic syndrome was 40.2% in men and 45.6% in women (P = .127. The prevalence of gait speed impairment was 29.3% in men and 12.5% in women (P Conclusion Among women, gait speed impairment is associated with low HDL cholesterol and inversely with abdominal obesity. These associations may be sex-dependent and warrant further research.

  5. Somatic complaints and refrain from buying prescribed medications. Results from a cross-sectional study on people 60 years and older living in Kaunas (Lithuania)

    Science.gov (United States)

    2012-01-01

    Background The use of medicines by elderly people is a growing area of concern in social pharmacy. A significant proportion of older people do not follow the recommendations from physicians and refrain from buying prescribed medications. The aim of this study is to evaluate associations between self-rated health, somatic complaints and refraining from buying prescribed medications by elderly people. Findings Data was collected in a cross-sectional study in 2009. We received 624 completed questionnaires (response rate – 48.9%) from persons aged 60–84 years living in Kaunas (Lithuania). Somatic complaints were measured with the 24 item version of the Giessen Complaint List (GBB-24). Logistic regression (Enter model) was used for evaluation of the associations between refraining from buying medications and somatic complaints. These associations were measured using odds ratio (OR) and calculating the 95% confidence interval (CI). The mean scores in total for the GBB scale and sub-scales (exhaustion, gastrointestinal and cardiovascular) were lowest among respondents who did not refrain from buying prescribed medications (means for GBB-24 scale: 21.04 vs. 24.82; p=0.001). Logistic regression suggests that somatic complaints were associated with a increased risk of refraining from buying prescribed medications (OR=1.35, 95% CI=1.15-1.60). Conclusions Somatic complaints were significantly associated with the decision to refrain from buying prescribed medications. PMID:23351159

  6. Older workers

    NARCIS (Netherlands)

    Ybema,J.F.; Giesen, F.

    2014-01-01

    Due to an ageing population and global economic competition, there is a societal need for people to extend their working lives while maintaining high work productivity. This article presents an overview of the labour participation, job performance, and job characteristics of older workers in the Eur

  7. Opportunistic detection of atrial fibrillation in subjects aged 65 years or older in primare care: a randomised clinical trial of efficacy. DOFA-AP study protocol

    Directory of Open Access Journals (Sweden)

    Pérula-de-Torres LuisÁ

    2012-10-01

    Full Text Available Abstract Background Clinical Practice Guidelines recommend using peripheral blood pulse measuring as a screening test for Atrial Fibrillation. However, there is no adequate evidence supporting the efficacy of such procedure in primary care clinical practice. This paper describes a study protocol designed to verify whether early opportunistic screening for Atrial Fibrillation by measuring blood pulse is more effective than regular practice in subjects aged 65 years attending primary care centers. Methods/design An cluster-randomized controlled trial conducted in Primary Care Centers of the Spanish National Health Service. A total of 269 physicians and nurses will be allocated to one of the two arms of the trial by stratified randomization with a 3:2 ratio (three practitioners will be assigned to the Control Group for every two practitioners assigned to the Experimental Group. As many as 12 870 patients aged 65 years or older and meeting eligibility criteria will be recruited (8 580 will be allocated to the Experimental Group and 4 290 to the Control Group. Randomization and allocation to trial groups will be carried out by a central computer system. The Experimental Group practitioners will conduct an opportunistic case finding for patients with Atrial Fibrillation, while the Control Group practitioners will follow the regular guidelines. The first step will be finding new Atrial Fibrillation cases. A descriptive inferential analysis will be performed (bivariate and multivariate by multilevel logistic regression analysis. Discussion If our hypothesis is confirmed, we expect Primary Care professionals to take a more proactive approach and adopt a new protocol when a patient meeting the established screening criteria is identified. Finally, we expect this measure to be incorporated into Clinical Practice Guidelines. Trial registration The study is registered as NCT01291953 (ClinicalTrials.gob

  8. Empowering billions with food safety and food security

    International Nuclear Information System (INIS)

    Full text: There are virtually millions of people -who die needlessly every year due to contaminated water and food. There are virtually many millions more who are starving due to an inadequate supply of food. Billions of pounds of food are unnecessarily wasted due to insect and other damage. Deaths and illness due to contaminated food or inadequate food are at catastrophic levels in many regions of the world. A majority of the food and water borne illnesses and deaths are preventable. It can be prevented by improved food production methods, improved food processing technologies, improved food distribution systems and improved personal hygiene. Food irradiation technology is over 100 years old. Yet, this technology is poorly understood by governments and corporate decision makers all around the world. Many consumers also are unfortunately misinformed of this technology. There is an urgent need for nations and people around the world to empower themselves with the knowledge and the expertise to harness this powerful technology. Widespread and sensible adoption of this technology can empower billions around the world with clean and abundant food supplies. It is unconscionable in the 21st century for governments to allow people to die or go hungry when the technology to prevent them is readily available

  9. A qualitative geographical information systems approach to explore how older people over 70 years interact with and define their neighbourhood environment.

    Science.gov (United States)

    Milton, Sarah; Pliakas, Triantafyllos; Hawkesworth, Sophie; Nanchahal, Kiran; Grundy, Chris; Amuzu, Antoinette; Casas, Juan-Pablo; Lock, Karen

    2015-11-01

    A growing body of literature explores the relationship between the built environment and health, and the methodological challenges of understanding these complex interactions across the lifecourse. The impact of the neighbourhood environment on health and behaviour amongst older adults has received less attention, despite this age group being potentially more vulnerable to barriers in their surrounding social and physical environment. A qualitative geographical information systems (QGIS) approach was taken to facilitate the understanding of how older people over 70 in 5 UK towns interact with their local neighbourhood. The concept of neighbourhood changed seasonally and over the lifecourse, and was associated with social factors such as friends, family, or community activities, rather than places. Spaces stretched further than the local, which is problematic for older people who rely on variable public transport provision. QGIS techniques prompted rich discussions on interactions with and the meanings of 'place' in older people. PMID:26513597

  10. Financial access to health care for older people in Cambodia: 10-year trends (2004-14) and determinants of catastrophic health expenses

    OpenAIRE

    Jacobs, Bart; de Groot, Richard; Fernandes Antunes, Adélio

    2016-01-01

    Background Older people make up an increasing proportion of the population in low- and middle-income countries. This brings a number of challenges, as their health needs are greater than, and different from, those of younger people. In general, these health systems are not geared to address their needs, and traditional support systems tend to erode, potentially causing financial hardship when accessing health care. This paper provides an overview of older Cambodians’ financial access to healt...

  11. Areva excellent business volume: backlog as of december 31, 2008: + 21.1% to 48.2 billion euros. 2008 revenue: + 10.4% to 13.2 billion euros

    International Nuclear Information System (INIS)

    AREVA's backlog stood at 48.2 billion euros as of December 31, 2008, for 21.1% growth year-on-year, including 21.8% growth in Nuclear and 16.5% growth in Transmission and Distribution. The Nuclear backlog came to 42.5 billion euros at December 31, 2008. The Transmission and Distribution backlog came to 5.7 billion euros at year-end. The group recognized revenue of 13.2 billion euros in 2008, for year-on-year growth of 10.4% (+9.8% like-for-like). Revenue outside France was up 10.5% to 9.5 billion euros, representing 72% of total revenue. Revenue was up 6.5% in the Nuclear businesses (up 6.3% LFL), with strong performance in the Reactors and Services division (+10.9% LFL) and the Front End division (+7.2% LFL). The Transmission and Distribution division recorded growth of 17% (+15.8% LFL). Revenue for the fourth quarter of 2008 rose to 4.1 billion euros, up 5.2% (+1.6% LFL) from that of the fourth quarter of 2007. Revenue for the Front End division rose to 3.363 billion euros in 2008, up 7.1% over 2007 (+7.2% LFL). Foreign exchange (currency translations) had a negative impact of 53 million euros. Revenue for the Reactors and Services division rose to 3.037 billion euros, up 11.8% over 2007 (+10.9% LFL). Foreign exchange (currency translations) had a negative impact of 47 million euros. Revenue for the Back End division came to 1.692 billion euros, a drop of 2.7% (-2.5% LFL). Foreign exchange (currency translations) had a negative impact of 3.5 million euros. Revenue for the Transmission and Distribution division rose to 5.065 billion euros in 2008, up 17.0% (+15.8% LFL)

  12. Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older.

    Science.gov (United States)

    Tiddens, H A; Geller, D E; Challoner, P; Speirs, R J; Kesser, K C; Overbeek, S E; Humble, D; Shrewsbury, S B; Standaert, T A

    2006-01-01

    Several inhaled drugs for use by cystic fibrosis (CF) patients are formulated for nebulizer use only. This therapy is time consuming and includes the risk of contamination of the nebulizers. Dry powder inhalers (DPI) can be an attractive alternative for CF drugs. Inhaled flow rate and volume, and the device resistance are important determinants for optimal dispersion of drug from a DPI. It is important to understand how these variables interact in the CF population in order to properly design a new DPI formulation targeted for these patients. The objective of this study was to assess the inspiratory variables of a representative population of CF subjects 6 years and older with varying degrees of lung disease while inhaling through resistances that simulate DPI devices. Ninety-six stable CF patients were enrolled, ages 6-54 years, FEV(1) 19-126% predicted. Subjects inhaled forcefully through four different resistances (0.019, 0.024, 0.038, and 0.048 kP(0.5)/LPM, respectively), while inspiratory time (IT(DPI)), peak inspiratory flow (PIF(DPI)), and volumes (V(DPI)) were measured. For any resistance, inspired V(DPI) increased with the older age groups; PIF(DPI) was similar between adults and adolescents but lower in the children. Subjects with lower FEV(1) had lower V(DPI) and PIF(DPI). As resistance increased, PIF(DPI) decreased, IT(DPI) increased, with no significant change in V(DPI). At the lowest resistance mean PIF(DPI) was 105 LPM (range 45-163) for all patients; 112 LPM (range 75-163) in adults; and 89 LPM (45-126) in children. Mean inspired V(DPI) was 1.75 L for all patients; 2.2 L (0.8-3.7) in adults; and 1.2 L (0.5-1.8) in children. At the lowest resistance a minimal flow rate of 30, 45, and 60 LPM was attained in 100%, 99%, and 96% of all patients. Volumes of 1.0, 1.5, and 2.0 L were attained by 85%, 57%, and 30% of the patients. At the highest resistance mean PIF(DPI) was 52 LPM (range 26-70) for all patients; 55 LPM (40-70) in adults; and 47 LPM (26

  13. Promoting mobility after hip fracture (ProMo: study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people

    Directory of Open Access Journals (Sweden)

    Sipilä Sarianna

    2011-12-01

    Full Text Available Abstract Background To cope at their homes, community-dwelling older people surviving a hip fracture need a sufficient amount of functional ability and mobility. There is a lack of evidence on the best practices supporting recovery after hip fracture. The purpose of this article is to describe the design, intervention and demographic baseline results of a study investigating the effects of a rehabilitation program aiming to restore mobility and functional capacity among community-dwelling participants after hip fracture. Methods/Design Population-based sample of over 60-year-old community-dwelling men and women operated for hip fracture (n = 81, mean age 79 years, 78% were women participated in this study and were randomly allocated into control (Standard Care and ProMo intervention groups on average 10 weeks post fracture and 6 weeks after discharged to home. Standard Care included written home exercise program with 5-7 exercises for lower limbs. Of all participants, 12 got a referral to physiotherapy. After discharged to home, only 50% adhered to Standard Care. None of the participants were followed-up for Standard Care or mobility recovery. ProMo-intervention included Standard Care and a year-long program including evaluation/modification of environmental hazards, guidance for safe walking, pain management, progressive home exercise program and physical activity counseling. Measurements included a comprehensive battery of laboratory tests and self-report on mobility limitation, disability, physical functional capacity and health as well as assessments for the key prerequisites for mobility, disability and functional capacity. All assessments were performed blinded at the research laboratory. No significant differences were observed between intervention and control groups in any of the demographic variables. Discussion Ten weeks post hip fracture only half of the participants were compliant to Standard Care. No follow-up for Standard Care or

  14. Coaching Older

    Directory of Open Access Journals (Sweden)

    Stacey Masters

    2012-08-01

    Full Text Available BackgroundFrail older people who are considering movement into residential aged care or returning home following a hospital admission often face complex and difficult decisions. Despite research interest in this area, a recent Cochrane review was unable to identify any studies of interventions to support decision-making in this group that met the experimental or quasi-experimental study design criteria. AimsThis study tests the impact of a multi-component coaching intervention on the quality of preparation for care transitions, targeted to older adults and informal carers. In addition, the study assesses the impact of investing specialist geriatric resources into consultations with families in an intermediate care setting where decisions about future care needs are being made. Method This study was a randomised controlled trial of 230 older adults admitted to intermediate care in Australia. Masked assessment at 3 and 12 months examined physical functioning, health-related quality of life and utilisation of health and aged care resources. A geriatrician and specialist nurse delivered a coaching intervention to both the older person and their carer/family. Components of the intervention included provision of a Question Prompt List prior to meeting with a geriatrician (to clarify medical conditions and treatments, medications, ‘red flags’, end of life decisions and options for future health care and a follow-up meeting with a nurse who remained in telephone contact. Participants received a printed summary and an audio recording of the meeting with the geriatrician.ConclusionThe costs and outcomes of the intervention are compared with usual care. Trial registration: Australian New Zealand Clinical Trials Registry.

  15. Older workers

    OpenAIRE

    Ybema, J.F.; Giesen, F.

    2014-01-01

    Due to an ageing population and global economic competition, there is a societal need for people to extend their working lives while maintaining high work productivity. This article presents an overview of the labour participation, job performance, and job characteristics of older workers in the European Union. The way in which several factors, including health, working conditions, skills and knowledge, and social and financial factors influence sustainable employability and the early retirem...

  16. Induction with lopinavir-based treatment followed by switch to nevirapine-based regimen versus non-nucleoside reverse transcriptase inhibitors-based treatment for first line antiretroviral therapy in HIV infected children three years and older.

    Directory of Open Access Journals (Sweden)

    Gerardo Alvarez-Uria

    Full Text Available The World Health Organization recommends non-nucleoside reverse transcriptase inhibitors (NNRTIs-based antiretroviral therapy (ART for children three years and older. In younger children, starting ART with lopinavir boosted with ritonavir (LPVr results in lower risk of virological failure, but data in children three years and older are scarce, and long-term ART with LPVr is problematic in resource-poor settings.Retrospective cohort of children three years and older who started triple ART including LPVr or a NNRTI between 2007 and 2013 in a rural setting in India. Children who started LPVr were switched to nevirapine-based ART after virological suppression. We analysed two outcomes, virological suppression (HIV-RNA 1000 copies/ml after virological suppression using Cox proportional hazard regression. A sensitivity analysis was performed using inverse probability of treatment weighting (IPTW based of propensity score methods.Of 325 children having a viral load during the first year of ART, 74/83 (89.2% in the LPVr group achieved virological suppression versus 185/242 (76.5% in the NNRTI group. In a multivariable analysis, the use of LPVr-based ART was associated with higher probability of virological suppression (adjusted odds ratio 3.19, 95% confidence interval [CI] 1.11-9.13. After IPTW, the estimated risk difference was 12.2% (95% CI, 2.9-21.5. In a multivariable analysis including 292 children who had virological suppression and available viral loads after one year of ART, children switched from LPVr to nevirapine did not have significant higher risk of virological failure (adjusted hazard ratio 1.18, 95% CI 0.36-3.81.In a cohort of HIV infected children three years and older in a resource-limited setting, an LPVr induction- nevirapine maintenance strategy resulted in more initial virological suppression and similar incidence of virological failure after initial virological suppression than NNRTI-based regimens.

  17. Qijiang Plans to Build 50 Billion Yuan Industrial Cluster for Transport-use Aluminum

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    The reporter learned from the China International Transport-use Aluminum Forum2015 that 5 years later Qijiang District is expected to develop transport-use aluminum industrial cluster with annual output of 50billion yuan.According to statistics,last year 1 in every 9automobile OEM manufacturers nationwide

  18. Handgrip strength, quadriceps muscle power, and optimal shortening velocity roles in maintaining functional abilities in older adults living in a long-term care home: a 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Kozicka I

    2016-05-01

    Full Text Available Izabela Kozicka, Tomasz Kostka Department of Geriatrics, Medical University of Lodz, Lodz, Poland Purpose: To assess the relative role of handgrip strength (HGS, quadriceps muscle power (Pmax, and optimal shortening velocity (υopt in maintaining functional abilities (FAs in older adults living in a long-term care home over a 1-year follow-up. Subjects and methods: Forty-one inactive older institutionalized adults aged 69.8±9.0 years participated in this study. HGS, Pmax, υopt, cognitive function using the Mini-Mental State Examination, depressive symptoms using the Geriatric Depression Scale, nutritional status using the Mini Nutritional Assessment (MNA, and physical activity (PA using the Seven-Day Physical Activity Recall Questionnaire were assessed at baseline and at 1-year follow-up. FAs were assessed with activities of daily living (ADL, instrumental ADL, and Timed Up & Go test. Results: Both at baseline and at follow-up, FAs were related to age, HGS, Pmax/kg, υopt, MNA, and PA. These associations were generally similar in both sexes. As revealed in multiple regression analysis, υopt was the strongest predictor of FA, followed by Pmax/kg, PA, and MNA. FA deteriorated after 1 year as measured by ADL and Timed Up & Go test. Pmax and υopt, but not HGS, also decreased significantly after 1 year. Nevertheless, 1-year changes in FAs were not related to changes in HGS, Pmax, υopt, or PA. Conclusion: The 1-year period of physical inactivity among older institutionalized adults was found to have a negative effect on their FAs, Pmax, and υopt. The present study demonstrates that Pmax and, especially, υopt correlated with FAs of older adults more than HGS, both at baseline and at follow-up. Despite this, 1-year natural fluctuations of PA, Pmax, and υopt are not significant enough to influence FAs in inactive institutionalized older adults. Keywords: aging, handgrip strength, institutionalization, functional status, physical activity

  19. Associations of Work-Related Factors and Work Engagement with Mental and Physical Health: A 1-Year Follow-up Study Among Older Workers

    NARCIS (Netherlands)

    Leijten, F.R.M.; Heuvel, S.G. van den; Beek, A.J. van der; Ybema, J.F.; Robroek, S.J.W.; Burdorf, A.

    2015-01-01

    Purpose The goals of this study were to determine whether, among older employees, unfavourable physical and psychosocial work-related factors were associated with poorer mental and physical health and whether high work engagement buffered the associations between unfavourable work-related factors an

  20. Why Is Health Literacy Related to Health? An Exploration among U.S. National Assessment of Adult Literacy Participants 40 Years of Age and Older

    Science.gov (United States)

    Ownby, Raymond L.; Waldrop-Valverde, Drenna; Taha, Jessica

    2012-01-01

    Health literacy has emerged as an important factor related to health in older persons. The reason for the link between health literacy and health outcomes is not clear. Possible explanations include common relations among income, education, access to health care, health-promotion behaviors, frequency of reading, and perceptual impairments. In this…

  1. Older siblings, pets and early life infections: impact on gut microbiota and allergy prevalence during the first three years of life

    DEFF Research Database (Denmark)

    Laursen, Martin Frederik; Zachariassen, Gitte; Bahl, Martin Iain;

    allergies did not differ substantially from that in children without symptoms. Conclusions: Early life infections might precede childhood respiratory allergy and are associated with low microbial diversity/richness during late infancy. The presence of older siblings affects the gut microbiota composition...

  2. Magnesium (Mg) Supplementation Improves Magnesium Status And Decreases Elevated C-reactive Protein in Adults Older Than 51 Years With Poor Quality Sleep.

    Science.gov (United States)

    NHANES data indicate that two-thirds of U.S. adults consume less than the RDA for Mg. A low Mg intake or status has been associated with poor quality sleep and inflammatory stress. Thus, 100 adults (22 males and 78 females) older than 51 yr with a Pittsburgh Sleep Quality Index (PSQI) higher than 5 ...

  3. Uranium in Canada: Billion-dollar industry

    International Nuclear Information System (INIS)

    In 1988, Canada maintained its position as the world's leading producer and exporter of uranium; five primary uranium producers reported concentrate output containing 12,400 MT of uranium, or about one-third of Western production. Uranium shipments made by these producers in 1988 exceeded 13,200 MT, worth Canadian $1.1 billion. Because domestic requirements represent only 15% of current Canadian output, most of Canada's uranium production is available for export. Despite continued market uncertainty in 1988, Canada's uranium producers signed new sales contracts for some 14,000 MT, twice the 1987 level. About 90% of this new volume is with the US, now Canada's major uranium customer. The recent implementation of the Canada/US Free Trade agreement brings benefits to both countries; the uranium industries in each can now develop in an orderly, free market. Canada's uranium industry was restructured and consolidated in 1988 through merger and acquisition; three new uranium projects advanced significantly. Canada's new policy on nonresident ownership in the uranium mining sector, designed to encourage both Canadian and foreign investment, should greatly improve efforts to finance the development of recent Canadian uranium discoveries

  4. Sneak Peek to the 2016 Billion-Ton Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    The 2005 Billion-Ton Study became a landmark resource for bioenergy stakeholders, detailing for the first time the potential to produce at least one billion dry tons of biomass annually in a sustainable manner from U.S. agriculture and forest resources. The 2011 U.S. Billion-Ton Update expanded and updated the analysis, and in 2016, the U.S. Department of Energy’s Bioenergy Technologies Office plans to release the 2016 Billion-Ton Report: Advancing Domestic Resources for a Thriving Bioeconomy.

  5. Redefining racial residential segregation and its association with physical activity among African Americans 50 years and older: a mixed methods approach.

    Science.gov (United States)

    Armstrong-Brown, Janell; Eng, Eugenia; Hammond, Wizdom Powell; Zimmer, Catherine; Bowling, J Michael

    2015-04-01

    Physical inactivity is one of the factors contributing to disproportionate disease rates among older African Americans. Previous literature indicates that older African Americans are more likely to live in racially segregated neighborhoods and that racial residential segregation is associated with limited opportunities for physical activity. A cross-sectional mixed methods study was conducted guided by the concept of therapeutic landscapes. Multilevel regression analyses demonstrated that racial residential segregation was associated with more minutes of physical activity and greater odds of meeting physical activity recommendations. Qualitative interviews revealed the following physical activity related themes: aging of the neighborhood, knowing your neighbors, feeling of safety, and neighborhood racial identity. Perceptions of social cohesion enhanced participants' physical activity, offering a plausible explanation to the higher rates of physical activity found in this population. Understanding how social cohesion operates within racially segregated neighborhoods can help to inform the design of effective interventions for this population. PMID:24812201

  6. Strategies to reduce the risk of falling: Cohort study analysis with 1-year follow-up in community dwelling older adults

    OpenAIRE

    John N. Morris; Howard, Elizabeth P.; Steel, Knight; Berg, Katherine; Tchalla, Achille; Munankarmi, Amy; David, Daniel

    2016-01-01

    Background According to the CDC, falls rank among the leading causes of accidental death in the United States, resulting in significant health care costs annually. In this paper we present information about everyday lifestyle decisions of the older adult that may help reduce the risk of falling. We pursued two lines of inquiry: first, we identify and then test known mutable fall risk factors and ask how the resolution of such problems correlates with changes in fall rates. Second, we identify...

  7. A qualitative geographical information systems approach to explore how older people over 70 years interact with and define their neighbourhood environment

    OpenAIRE

    Milton, S.; Pliakas, T; Hawkesworth, S; Nanchahal, K.; Grundy, C.; Amuzu, A; Casas, JP; Lock, K.

    2015-01-01

    A growing body of literature explores the relationship between the built environment and health, and the methodological challenges of understanding these complex interactions across the lifecourse. The impact of the neighbourhood environment on health and behaviour amongst older adults has received less attention, despite this age group being potentially more vulnerable to barriers in their surrounding social and physical environment. A qualitative geographical information systems (QGIS) appr...

  8. Company Policies on Working Hours and Night Work in Relation to Older Workers' Work Ability and Work Engagement: Results From a Dutch Longitudinal Study with 2 Year Follow-Up.

    Science.gov (United States)

    van der Meer, Laudry; Leijten, Fenna R M; Heuvel, Swenneke G; Ybema, Jan F; de Wind, Astrid; Burdorf, Alex; Geuskens, Goedele A

    2016-06-01

    Purpose To longitudinally investigate (1) whether lower work ability and work engagement predict the use of company policies on reduced working hours and exemption from evening/night work among older workers, and (2) whether using such policies subsequently contribute to higher work ability and work engagement. Methods In total 6922 employees (45-64 years) participating in the first three waves of the Study on Transitions in Employment, Ability and Motivation were included. Participants yearly filled out an online questionnaires. Regression analyses were applied to study the influence of baseline work ability and work engagement on the incident use of policies during the first year of follow-up, and the incident use of these policies on work ability and work engagement during the second year of follow-up. Results Employees with a higher work ability were less likely to start using the policy 'reduced working hours' [OR 0.91 (95 % CI 0.83-0.98)]. Starting to use this policy was in turn related to lower work ability 1 year later [B -0.28 (95 % CI -0.47 to -0.08)]. Starting to use the policy 'exemption from evening/night work' was related to higher work engagement 1 year later [B 0.23 (95 % CI 0.07-0.39)]. Conclusions Low work ability precedes the use of some company policies aiming to support sustainable employability of older workers. Further research is needed to explore whether company policies result in a (longstanding) improvement, or reduced deterioration, of older workers' employability. PMID:26250870

  9. A 17-billion-solar-mass black hole in a group galaxy with a diffuse core

    OpenAIRE

    Thomas, Jens; Ma, Chung-Pei; McConnell, Nicholas J.; Greene, Jenny E.; Blakeslee, John P.; Janish, Ryan

    2016-01-01

    Quasars are associated with and powered by the accretion of material onto massive black holes; the detection of highly luminous quasars with redshifts greater than z = 6 suggests that black holes of up to ten billion solar masses already existed 13 billion years ago. Two possible present-day dormant descendants of this population of active black holes have been found in the galaxies NGC 3842 and NGC 4889 at the centres of the Leo and Coma galaxy clusters, which together form the central regio...

  10. U of M seeking $1.1 billion in projects for Soudan Mine lab.

    CERN Multimedia

    2003-01-01

    The University of Minnesota is hoping that groundbreaking research underway at its labs at the Soudan Underground Mine near Tower will help secure up to $1.1 billion in the next 5 to 20 years to expand its work into particle physics (1 page).

  11. Chongqing Bosai plans to make an investment of RMB 10 billion in bauxite

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Following the acquisition of Guyana bauxite mine with USD 600 million,Chongqing Bosai Group has planned to make an investment of RMB 10 billion in expansion of bauxite pro- duction in the coming 5 years and to purchase a

  12. Price of next big thing in physics: $6.7 billion

    CERN Multimedia

    Overbye, Dennis

    2007-01-01

    The price of exploring inner space went up Thursday. The machine discusses in a news conference in Beijing, will be 20 miles long and would cost about $6.7 billion and 13'000 person-years of labor to be built. (1,5 page)

  13. Chinalco Plans to Invest 6 Billion Yuan in Guizhou in 2012

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>According to Xiong Weiping,President of Chinalco,Chinalco plans to invest 6 billion yuan in Guizhou this year;it will step up aluminum industrial base projects and co-generation projects in Guiyang and Zunyi,take strong measures to support deep processing of aluminumin Guizhou,extend the industry chain,and

  14. Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial

    OpenAIRE

    Meattini, Icro; Saieva, Calogero; Marrazzo, Livia; Di Brina, Lucia; Pallotta, Stefania; Mangoni, Monica; Meacci, Fiammetta; Bendinelli, Benedetta; Francolini, Giulio; Desideri, Isacco; De Luca Cardillo, Carla; Scotti, Vieri; Furfaro, Ilaria Francesca; Rossi, Francesca; Greto, Daniela

    2015-01-01

    The purpose of this study was to report the efficacy and the safety profile on the subset of selected early breast cancer (BC) patients aged 70 years or older from a single-center phase 3 trial comparing whole breast irradiation (WBI) to accelerated partial breast irradiation (APBI) using intensity-modulated radiation therapy technique. Between 2005 and 2013, 520 patients aged more than 40 years old were enrolled and randomly assigned to receive either WBI or APBI in a 1:1 ratio. Eligible pat...

  15. Low-dose amiodarone for the prevention of atrial fibrillation after coronary artery bypass grafting in patients older than 70 years

    Institute of Scientific and Technical Information of China (English)

    GU Song; SU Pi-xiong; LIU Yan; YAN Jun; ZHANG Xi-tao; WANG Tian-you

    2009-01-01

    Background Atrial fibrillation (AF) is one of the most common arrhythmia after coronary artery bypass grafting (CABG), which not only increases the suffering of the patients, but also prolongs hospital stay and enhances cost of care, especially for patients older than 70 years. This study was designed to evaluate the efficacy and safety of low-dose amiodarone in the prevention of AF after CABG, especially for the elderly.Methods Two hundred and ten senile patients undergoing off-pump CABG were included in this prospective, randomized, double-blind and placebo controlled study. Patients were given 10 mg/kg of amiodarone (low-dose amiodarone group, n=100) or placebo (control group, n=110) daily for 7 days before surgery and followed by 200 mg of amiodarone or placebo daily for 10 days postoperatively.Results Postoperative AF occurred in 16 patients (16%) receiving amiodarone and in 36 (37.7%) patients receiving placebo (P=0.006). AF occurred at (58.13±16.63) hours after CABG in the low-dose amiodarone group and at (45.03±17.40) hours in the control group (P=0.018). The maximum ventricular rate during AF was significantly slower in the low-dose amiodarone group ((121.42±28.91) beats/min) than in the control group ((134.11 ±30.57) beats/min, P=0.036). The duration of AF was (10.92±9.56) hours for the low-dose amiodarone group compared with (14.81 ±10.37) hours for the control group (P=0.002). The postoperative left ventricular ejection fraction (LVEF) was significantly improved in the low-dose amiodarone group (from (59.9 ±10.3)% to (63.4±11.4)%, P=0.001), and significantly higher compared with the control group ((58.5±10.7)%, P=0.002). Both groups had a similar incidence of complication other than rhythm disturbances (12.0% vs 16.4%, P=0.368). The low-dose amiodarone group patients had shorter hospital stays ((11.8±3.2) days vs (13.8±4.7) days, P=0.001) and lower cost of care (RMB (79 115±16 673) Yuan vs RMB (84 997±21 587) Yuan, P=0.031) than that of

  16. Proton collider breaks the six-billion-dollar barrier

    CERN Multimedia

    Vaughan, C

    1990-01-01

    The SSC will cost at least 1 billion more than its estimated final price of 5.9 billion dollars. Critics in congress believe the final bill could be double that figure. The director of the SSC blames most of the increase in cost on technical problems with developing the superconducting magnets for the SSC (1/2 page).

  17. Economic toll of AIDS put at $10 billion in Canada.

    Science.gov (United States)

    1996-11-29

    John McCallum, Chief economist at the Royal Bank of Canada, announced that AIDS has cost the nation's economy $10 billion since 1981. These calculations included losses in both direct medical care and human capital. This monetary figure is expected to rise to $36 billion by 2010. An estimated 42,500 to 45,000 Canadians are infected with HIV. PMID:11364044

  18. ZTE Records 21.52% Increase in Revenue to RMB37.3 Billion in the First Half of 2011%ZTE Records 21.52% Increase in Revenue to RMB37.3 Billion in the First Half of 2011

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On August 30, 2011, ZTE Corporation announced a 21.52% increase in operating revenue to RMB37.337 billion for the half year ended June 30, 2011. Based on HKFRS, interim net profit fell 12.33% to RMB769 million. Basic earnings per share were RMB0.27. Applying PRC ASBEs, operating revenue for the first half rose 21.52% to RMB37.34 billion.

  19. Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older

    OpenAIRE

    Bunce, D; Kivipelto, M.; Wahlin, A

    2004-01-01

    Apolipoprotein E (APOE), vitamin B12, and folate were examined in relation to free recall among 167 community-based older adults. Cognitive support at encoding and retrieval was also taken into account. Participants were classified as APOE e4 or non-e4 allele carriers and as either low or normal vitamin B12 or folate status. A significant association was identified between low vitamin B12 and the e4 genotype in respect to free recall, but only in circumstances of low cognitive support. This r...

  20. Transtorno de ansiedade generalizada em idosos com oitenta anos ou mais Generalized anxiety disorder in a population aged 80 years and older

    Directory of Open Access Journals (Sweden)

    Flávio MF Xavier

    2001-06-01

    qualidade de vida relativa à saúde.OBJECTIVE: To describe the prevalence of generalized anxiety disorder (GAD in a community-dwelling population aged 80 years and older. Also, to compare sleep patterns, cognitive function and prevalence rate of other psychiatric conditions between healthy controls and GAD subjects. METHODS: DSM-IV criteria were used to diagnose GAD. A representative random sample of 77 community-dwelling subjects (35%, aged 80 years or more from the rural southern county of Veranopolis, Brazil, was selected. Sleep patterns were assessed using the Pittsburgh Sleep Quality Index and a 2-week sleep/wake diary. Five neuropsychological tests (Buschke-Fuld Selective Reminding Test, CERAD word list, verbal fluency test, and two sub-tests of the Wechsler memory scale were used for cognitive evaluation. RESULTS: The estimated GAD prevalence was 10.6 percent. GAD was associated with major depression, with a significant greater number of depressive symptoms as measured by the Geriatric Depression Scale and with a significant more frequent occurrence of minor depression. Sleeping patterns and cognition function among GAD subjects were not compromised. The severity of physical diseases was similar in both GAD subjects and healthy controls. GAD was associated with a significantly lower health-related quality of life. CONCLUSIONS: In comparison with previous studies, the prevalence of GAD is higher in the studied population. This disorder is frequently associated with both depressive symptoms and a lower health-related quality of life.

  1. Performance in Older Adults

    Directory of Open Access Journals (Sweden)

    David Predovan

    2012-01-01

    Full Text Available Growing evidence supports the use of physical training interventions to improve both physical and cognitive performances in healthy older adults. Few studies have examined the impact of aerobic exercise on Stroop task performance, a measure of executive functions. In the current 3-month aerobic training study, 50 older adults (mean age = 67.96 ± 6.25 years were randomly assigned to either a three-month physical training group or to a control group (waiting list. Training sessions were 3 times per week for 60 minutes. All participants completed pre- and post-test measures of cognitive performance using the modified Stroop task and physical performance (Rockport one-mile test. Compared to controls, the training group showed significant improvements in physical capacity (P<0.001 and enhanced Stroop performance, but only in the inhibition/switching condition (P<0.03. Furthermore, the increase in aerobic capacity induced by the training regimen correlated negatively with reaction time in the inhibition/switching condition of the Stroop task at posttest (r=−0.538; P=0.007. Importantly, the reported gains in cognitive performance were observed after only three months of physical training. Taken together, the results suggest that even short-term physical interventions can enhance older adults’ executive functions.

  2. Short-term prognostic value of forced expiratory volume in 1 second divided by height cubed in a prospective cohort of people 80 years and older

    OpenAIRE

    Turkeshi, Eralda; Vaes, Bert; Andreeva, Elena; Matheï, Cathy; Adriaensen, Wim; Van Pottelbergh, Gijs; Degryse, Jean-Marie

    2015-01-01

    Spirometry-based parameters of pulmonary function such as forced expiratory volume in 1 second (FEV1) have prognostic value beyond respiratory morbidity and mortality. FEV1 divided by height cubed (FEV1/Ht(3)) has been found to be better at predicting all-cause mortality than the usual standardization as percentage of predicted "normal values" (FEV1%) and its use is independent of reference equations. Yet, limited data are available on the very old adults (80 years and older) and in associati...

  3. Short-term prognostic value of forced expiratory volume in 1 second divided by height cubed in a prospective cohort of people 80 years and older

    OpenAIRE

    Turkeshi, Eralda; Vaes, Bert; Andreeva, Elena; Matheï, Catharina; Adriaensen, Wim; Van Pottelbergh, Gijs; Degryse, Jean-Marie

    2015-01-01

    Background Spirometry-based parameters of pulmonary function such as forced expiratory volume in 1 second (FEV1) have prognostic value beyond respiratory morbidity and mortality. FEV1 divided by height cubed (FEV1/Ht3) has been found to be better at predicting all-cause mortality than the usual standardization as percentage of predicted "normal values" (FEV1%) and its use is independent of reference equations. Yet, limited data are available on the very old adults (80 years and older) and in ...

  4. User-centered Development of Video telephony for Servicing Mainly Older Users: Review and Evaluation of an Approach Applied for 10 Years

    Directory of Open Access Journals (Sweden)

    Seppo Väyrynen

    2006-01-01

    Full Text Available A research and development (R&D approach has been applied to video telephony (VT in northern Finland since 1994 by broad consortia. The focus has been on the considerable involvement of ergonomics within the engineering and implementation of VT. This multidisciplinary participatory ergonomic R&D approach (PERDA is described briefly, in general and through two cases. The user-centeredness should be discernible in this sociotechnical systemic entity. A consortium—comprising mainly manufacturers, individual and organizational users of technological products, and R&D organizations—serves as a natural context for product development. VT has been considered to have much potential for enhancing (multimedia interaction and effective multimodal communication, thereby facilitating many activities of everyday life and work. An assessment of the VT system, called HomeHelper, involved older citizens, as clients or customers, and the staff of social, health, and other services.

  5. Academic Pork Barrel Tops $2-Billion for the First Time.

    Science.gov (United States)

    Brainard, Jeffrey; Borrego, Anne Marie

    2003-01-01

    Describes how, despite the growing budget deficit, Congress directed a record $2 billion to college projects in 2003, many of them dealing with security and bioterrorism. Includes data tables on the earmarks. (EV)

  6. God particle disappears down 6 billion pound drain

    CERN Multimedia

    Henderson, M

    2001-01-01

    An estimated 6 billion pounds has been spent looking for the Higgs particle over the last three decades. Recent results from LEP though, are now causing some scientists to doubt that it exists at all (1 page).

  7. Summary and Comparison of the 2016 Billion-Ton Report with the 2011 U.S. Billion-Ton Update

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    In terms of the magnitude of the resource potential, the results of the 2016 Billion-Ton Report (BT16) are consistent with the original 2005 Billion-Ton Study (BTS) and the 2011 report, U.S. Billion-Ton Update: Biomass Supply for a Bioenergy and Bioproducts Industry (BT2. An effort was made to reevaluate the potential forestland, agricultural, and waste resources at the roadside, then extend the analysis by adding transportation costs to a biorefinery under specified logistics assumptions to major resource fractions.

  8. Comparison of Clinicopathological Features and Treatments between Young (≤40 Years) and Older (>40 Years) Female Breast Cancer Patients in West China: A Retrospective, Epidemiological, Multicenter, Case Only Study

    OpenAIRE

    Ke Wang; Yu Ren; Hongyuan Li; Ke Zheng; Jun Jiang; Tianning Zou; Binlin Ma; Hui Li; Qilun Liu; Jianghua Ou; Ling Wang; Wei Wei; Jianjun He; Guosheng Ren

    2016-01-01

    The incidence of young cases of breast cancer is higher in China compared to the western world. We aimed to explore differences in risk factors, clinicopathological features and treatment modes of young female breast cancer compared to older patients in West China. We collected clinical information from 12,209 female breast cancer patients in West China, including risk factors, clinicopathological features and treatment modes, from January 2010 to December 2012. Chi-square tests and the multi...

  9. Mining survival in parts per billion

    International Nuclear Information System (INIS)

    The paper discusses the economic situation in the coal industry of Utah. Coal prices are down for the tenth year in a row, Utah is isolated from major markets and freight rates are high, and the state legislature has not dropped the issue of a coal severance tax. The author believes the only potential for increased use of Utah coal is the Pacific Rim countries. Environmental issues are also discussed

  10. DOE wants $1 billion from Hanford overhaul

    International Nuclear Information System (INIS)

    This article is a review of the agreement between DOE/Hanford site contractors and state and federal regulators to slice $1B from the cleanup budget over the next three years. DOE has unveiled a cost-cutting blueprint for the facility. It was also noted that DOE will accelerate the rebid of the MAO contract by six months, from December 1996 to June 1996, and the incumbent (Westinghouse Hanford) expects to compete in that effort

  11. LLNL's Big Science Capabilities Help Spur Over $796 Billion in U.S. Economic Activity Sequencing the Human Genome

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Jeffrey S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-07-28

    LLNL’s successful history of taking on big science projects spans beyond national security and has helped create billions of dollars per year in new economic activity. One example is LLNL’s role in helping sequence the human genome. Over $796 billion in new economic activity in over half a dozen fields has been documented since LLNL successfully completed this Grand Challenge.

  12. Sugar-sweetened beverage intake before 6 years of age and weight or BMI status among older children: systematic review of prospective studies

    Directory of Open Access Journals (Sweden)

    Eugenia Pérez-Morales

    2013-02-01

    Full Text Available The purpose of this study was to conduct a systematic review of prospective studies that examined the association between sugar-sweetened beverage intake before 6y of age and later weight or BMI status among older children. An electronic literature search was conducted in the MEDLINE/PubMed, SciELO, and EBSCO databases of prospective studies published from 2001 to 2011. Seven studies were analyzed. The study population was from 72 to 10,904 children. Three studies showed a consistent association between SSB intake before 6 y of age and increased weight, BMI, or waist circumference later in childhood, one study showed a positive trend of consumption of SSB and childhood obesity and the OR for incidence of overweight by baseline beverage intake was 1.04, another study it was observed that an increase in total sugar intake and sugar from sweets and beverages in children 1-2 y of age and 7-9 y of age have a tendency to increase BMI, and two studies showed no association. In conclusion, although the trend of the reviews studies, indicate an association between sugar-sweetened beverage intake before 6 y of age and increased weight, BMI or waist circumference later in childhood, to date, the results are inconsistent, and the two studies with the higher number of children showed a positive association.

  13. Eight billion asteroids in the Oort cloud

    CERN Document Server

    Shannon, Andrew; Veras, Dimitri; Wyatt, Mark

    2014-01-01

    The Oort cloud is usually thought of as a collection of icy comets inhabiting the outer reaches of the Solar system, but this picture is incomplete. We use simulations of the formation of the Oort cloud to show that ~4% of the small bodies in the Oort cloud should have formed within 2.5 au of the Sun, and hence be ice-free rock-iron bodies. If we assume these Oort cloud asteroids have the same size distribution as their cometary counterparts, the Large Synoptic Survey Telescope should find roughly a dozen Oort cloud asteroids during ten years of operations. Measurement of the asteroid fraction within the Oort cloud can serve as an excellent test of the Solar system's formation and dynamical history. Oort cloud asteroids could be of particular concern as impact hazards as their high mass density, high impact velocity, and low visibility make them both hard to detect and hard to divert or destroy. However, they should be a rare class of object, and we estimate globally catastrophic collisions should only occur ...

  14. Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥ 40 years of age).

    Science.gov (United States)

    Coker-Gurkan, Ajda; Coskun, Deniz; Arisan, Elif Damla; Obakan, Pinar; Soylu, Özer; Unsal, Narcin Palavan

    2015-07-01

    Inflammation and genetics have key roles in the pathogenesis of atherosclerosis, and the etiology of myocardial infarction (MI). Recent studies have indicated that lower serum levels of fetuin-A may accelerate the vascular mineralization process, which leads to pathophysiological conditions, such as coronary heart disease and chronic renal failure. The aim of the present study was to evaluate the association between specific fetuin-A polymorphisms (742 and 766) that are associated with circulating serum levels, and MI cases. The study consisted of 292 participants; 146 healthy control subjects and 146 patients with MI. The patient group was divided into two subgroups: 56 MI ≤ 40 years and 90 MI ≥ 40 years. The genotype distribution of fetuin 742 (C/T) and fetuin 766 (C/G) were determined by restriction enzyme digestion of polymerase chain reaction products. A significant difference was determined between the patients with MI and the control subjects with regards to fetuin-A 742 C/T gene polymorphism (P=0.028), regardless of age. Genotype distributions of fetuin-A 742 (C/G, P=0.004) and 766 (C/T, P=0.017) were statistically different in the older patients with MI (MI ≥ 40 years old), as compared with the healthy controls; however, there were no significant differences between the younger patients with MI and the controls, with regards to fetuin-A 742 C/T (P=0.519) and 766 C/G (P=0.653) gene polymorphisms. In addition, an association was observed between the presence of fetuin-A 742 T and 766 G alleles, and MI cases. The present study demonstrates that fetuin-A 742 (C/T) and 766 (C/G) genotypes may be risk factors for MI in patients older than 40 years of age. PMID:25815703

  15. Exploring Older Adults' Health Information Seeking Behaviors

    Science.gov (United States)

    Manafo, Elizabeth; Wong, Sharon

    2012-01-01

    Objective: To explore older adults' (55-70 years) health information-seeking behaviors. Methods: Using a qualitative methodology, based on grounded theory, data were collected using in-depth interviews. Participants were community-living, older adults in Toronto, Canada who independently seek nutrition and health information. Interview transcripts…

  16. Sleep Changes in Older Adults

    Science.gov (United States)

    ... might get sleepy earlier in the evening. Older adults may have insomnia, which makes it hard to fall asleep when they go to bed or stay asleep all night. They might wake up very early in the ... sleep problems. By the time an adult is over 65 years old, his or her ...

  17. Chongqing Hechuan District Plans to Build 10 Billion Yuan Size Aluminum Industry Park

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Recently,the reporter learned from Chongqing Hechuan District Aluminum Industry Integration Enterprise Discussion Meeting that Hechuan District would build aluminum industrial park at Caojie Development Park,and strive to fulfill 10 billion yuan output value within 3 to 5 years.It has been learned that Hechuan District currently has 29 aluminum product enterprises(including enterprises with aluminum and aluminum products as raw material),in which 9

  18. Global Organic Food & Beverages Market to Reach USD 211.44 Billion by 2020

    OpenAIRE

    Haakon, Johnson

    2014-01-01

    Global organic food & beverages market is expected to reach USD 211.44 billion by 2020, growing at a CAGR of 15.7% from 2014 to 2020. Growing adoption of organic food & beverages owing to associated health benefits and eco-friendly characteristics is expected to drive demand over the next six years. In addition, regulatory support for organic farming is also expected to have a positive influence on the market by improving supply and product quality.

  19. Older Consumers Safety Test

    Science.gov (United States)

    ... Pool Safely Home / Safety Education / Safety Guides / Home Older Consumers Safety Test This is a quiz on consumer ... mind when you think of Safety for the Older Consumer? Smoke Alarms? Hand Rails? Good Health? These are ...

  20. Older Adults and Depression

    Science.gov (United States)

    ... Older Adults and Depression Share Older Adults and Depression Download PDF Download ePub Download Mobi Order a ... If so, you may have depression. What is depression? Everyone feels down or sad sometimes, but these ...

  1. Violence against older women.

    Science.gov (United States)

    2016-07-01

    Domestic abuse is widespread and indiscriminate. Older women living with domestic abuse experience a number of health-related concerns and significant mental health issues. Research suggests that the needs of older women experiencing domestic abuse are not being met by existing services. This article examines the issues that older women face as a result of abusive relationships and the barriers to seeking help. Research suggests that a stepped approach, tailored to suit older women's needs, could be beneficial. PMID:27384810

  2. Sexuality in Older Adults

    Science.gov (United States)

    MENU Return to Web version Sexuality in Older Adults Sexuality in Older Adults What are the benefits of a healthy sex life for older adults? Sex is ... concerns, and acknowledge new relationships with respect. Bibliography Sexuality in Later Life by National Institute on Aging ( ...

  3. Incidence, patterns and severity of reported unintentional injuries in Pakistan for persons five years and older: results of the National Health Survey of Pakistan 1990–94

    Directory of Open Access Journals (Sweden)

    Qureshi Huma I

    2007-07-01

    Full Text Available Abstract Background National level estimates of injuries are not readily available for developing countries. This study estimated the annual incidence, patterns and severity of unintentional injuries among persons over five years of age in Pakistan. Methods National Health Survey of Pakistan (NHSP 1990–94 is a nationally representative survey of the household. Through a two-stage stratified design, 18, 315 persons over 5 years of age were interviewed to estimate the overall annual incidence, patterns and severity of unintentional injuries for males and females in urban and rural areas over the preceding one year. Weighted estimates were computed adjusting for complex survey design using surveyfreq and surveylogistic option of SAS 9.1 software. Results The overall annual incidence of all unintentional injuries was 45.9 (CI: 39.3–52.5 per 1000 per year; 59.2 (CI: 49.2–69.2 and 33.2 (CI: 27.0–39.4 per 1000 per year among males and females over five years of age, respectively. An estimated 6.16 million unintentional injuries occur in Pakistan annually among persons over five years of age. Urban and rural injuries were 55.9 (95% CI: 48.1–63.7 and 41.2 (95% CI: 32.2–50.0 per 1000 per year, respectively. The annual incidence of injuries due to falls were 22.2 (95% CI: 18.0–26.4, poisoning 3.3 (95%CI: 0.5–6.1 and burn was 1.5 (95%CI: 0.9–2.1 per 1000 per year. The majority of injuries occurred at home 19.2 (95%CI: 16.0–22.4 or on the roads 17.0 (95%CI: 13.8–20.2. Road traffic/street, school and urban injuries were more likely to result in handicap. Conclusion There is high burden of unintentional injuries among persons over five years of age in Pakistan. These results are useful to plan further studies and prioritizing prevention programs on injuries nationally and other developing countries with similar situation.

  4. Nocturia in older men.

    Science.gov (United States)

    van Doorn, Boris; Bosch, J L H Ruud

    2012-01-01

    Nocturia is a common and bothersome symptom that impacts on sleep-quality and quality of life. Nocturia often has a multi-factorial etiology which makes thorough assessment of the complaint indispensable. This review summarizes the definition of nocturia, its epidemiology, clinical presentation, pathophysiology, diagnostics, and treatment options with special reference to older men. Nocturia is defined as a nocturnal voiding frequency of two or more, based on impact on quality of life. It is very prevalent in older men. Apart from the negative effects of sleep-disruption, it may be a risk-factor for hip fractures and increased mortality. Most common causes are: nocturnal polyuria, 24-h polyuria, overactive bladder (sometimes due to BPH) and sleep disturbance. A clear understanding of the etiology in the individual patient is indispensable when addressing the various possible causes and co-morbidities. Most important tool for this is the frequency-volume chart, but also patient history, physical examination and serum analysis. For treatment, lifestyle adjustments are often helpful. Medical therapy with 5-alpha reductase inhibitors, alpha-blockers, a combination of the two, or anti-muscarinics, has a limited effect. Most important medical option is desmopressin (arginine vasopressin analogue); however, treatment with this drug is limited to men under 65 years mainly due to the risk of hyponatraemia. PMID:22079871

  5. Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project

    OpenAIRE

    Lacey, RJ; Strauss, VY; Rathod, T; Belcher, J; Croft, PR; Natvig, B; Wilkie, R; McBeth, J.

    2015-01-01

    Objective Most pain in patients aged ≥50 years affects multiple sites and yet the predominant mode of presentation is single-site syndromes. The aim of this study was to investigate if pain sites form clusters in this population and if any such clusters are associated with health factors other than pain. Setting Six general practices in North Staffordshire, UK. Design Cross-sectional, postal questionnaire, study. Participants Community-dwelling adults aged ≥50 years registered at the general ...

  6. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

    DEFF Research Database (Denmark)

    Inzitari, Domenico; Pracucci, Giovanni; Poggesi, Anna; Carlucci, Giovanna; Barkhof, Frederik; Chabriat, Hugues; Erkinjuntti, Timo; Fazekas, Franz; Ferro, José M; Hennerici, Michael; Langhorne, Peter; O'Brien, John; Scheltens, Philip; Visser, Marieke C; Wahlund, Lars-Olof; Waldemar, Gunhild; Wallin, Anders; Pantoni, Leonardo; NN, NN

    2009-01-01

    , history of atrial fibrillation, and complaint of gait disturbances. The effect of severe changes remained significant independently of baseline degree of atrophy and number of infarcts. Incident stroke and dementia only slightly modified this effect. CONCLUSION: The three year results of the LADIS study...... cerebral infarcts and atrophy. MAIN OUTCOME MEASURE: Transition from no disability (defined as a score of 0 or 1 on the instrumental activities of daily living scale) to disability (score >/=2) or death over three year follow-up. Secondary outcomes were incident dementia and stroke. RESULTS: Over a mean...

  7. Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures

    Directory of Open Access Journals (Sweden)

    Jun Iwamoto

    2009-09-01

    Full Text Available Jun Iwamoto1, Atsushi Miyata2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Internal Medicine, Yahata Clinic, Tokyo, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: A retrospective study was conducted to evaluate the outcome of treatment with alendronate (ALN for 5 years in postmenopausal Japanese women with an increased risk of fractures. Forty postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures (mean age: 75.4 years were analyzed; 33 patients were treated with alendronate and 7 were treated with alfacalcidol (ALF, controls in an outpatient clinic run by general practitioners. The metacarpal bone mineral density (BMD measured using a computed X-ray densitometer, urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX, and serum levels of alkaline phosphatase (ALP were monitored during the 5-year treatment period. The urinary NTX and serum ALP levels decreased significantly in the ALN group, compared with the ALF group. The metacarpal BMD was sustained in the ALN group but decreased significantly in the ALF group; the difference between these two groups was also significant. The present study evaluated the outcome of treatment with ALN for 5 years in postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures. ALN successfully suppressed bone turnover and sustained the metacarpal BMD over the 5-year period of treatment in postmenopausal Japanese women with an increased risk of fractures.Keywords: alendronate, osteoporosis, osteopenia, risk factors for fractures, postmenopausal women

  8. [Six billion people: how the continents were populated--yesterday, today, and tomorrow].

    Science.gov (United States)

    Dupaquier, J

    1998-01-01

    World population growth from settlement of the continents to future population size is broadly traced in this work. Population growth has accelerated greatly in the past two centuries and especially since 1950. The first billion was reached only in 1850, while the fifth billion, in 1986, required only 11 years. Past population growth was slow, irregular, and variable from continent to continent. Population estimates for prehistory have a margin of error of around 50%. Modern man first appeared in Africa or possibly the Middle East around 100,000 BC. The three great centers of population in China, India, and the Middle East and Mediterranean area developed during the Neolithic Revolution and have maintained their importance. At least 500,000 years ago, humans began using fire and clothing to escape the limits of their biotype and geographic area of origin. The peopling of the continents was not achieved by massive displacement of surplus population, but by movement of small groups into empty space where they proliferated. World population was an estimated 460-510 million in 1500, with probably 135 million in China, 95 million in India, and 80 million in Europe. The balance between fertility and mortality postulated by transition theory has not occurred in Europe. World population is projected to increase from 2.5 billion to 6 billion between 1950 and 2000, with 61% in Asia, 12% in Africa, 9% in Latin America, and 5% in Europe. The world rate of population growth is still about 1.4% annually. The demographic explosion will have been a transitory episode in human history, but revolutionary in its impact. PMID:12179517

  9. Prevalence of symptomatic knee, hand and hip osteoarthritis among individuals 40 years or older: a study conducted in İzmir city

    OpenAIRE

    Yesil, Hilal; Hepguler, Simin; Ozturk, Cihat; Capaci, Kazım; Yesil, Murat

    2013-01-01

    Objective: This cross-sectional study was conducted to determine the prevalence of symptomatic knee, hand and hip osteoarthritis among men and women at or over 40 years of age, living in the Bayraklı Adalet district of İzmir. Methods: The study included a sample size of 522 people calculated using the Epi Info™ software. Demographic information, weight, height and body mass index were recorded. Patients were physically examined for evidence of osteoarthritis, such as joint tenderness, ran...

  10. The Association between the Consumption of Fish/Shellfish and the Risk of Osteoporosis in Men and Postmenopausal Women Aged 50 Years or Older

    OpenAIRE

    Eunjin Choi; Youngsoon Park

    2016-01-01

    Fish rich in n-3 polyunsaturated fatty acids have been suggested to have a favorable effect on bone health, but previous epidemiologic studies have shown inconsistent results. The purpose of the present study was to investigate the hypothesis that the consumption of fish and shellfish is positively associated with bone mass and negatively associated with the risk of osteoporosis in Koreans and Americans. Men and postmenopausal women ≥50 years old from the Korean National Health and Nutrition ...

  11. The China-ROK Trade Surpasses US$130 Billion

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ In 2006,the important trade partnership between China and POK was further strengthened and consolidated.By the end of 2005,POK recognized China's status of market economy, making the bilateral trade environment more fair and reasonable.The governments of both sides have strived for the target of increasing the bilateral trade to US$200 billion by 2012.

  12. With US$5 Billion,China Purchases 42 Boeing Planes

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ On August 8, Air China, China Eastern Airlines, Shanghai Airlines, Xiamen Airlines signed the final Purchase agreement of 42 Boeing planes with Boeing. The price in catalogue is US$5.04 billion. The first plane will be delivered in 2008.

  13. With US$5 Billion,China Purchases 42 Boeing Planes

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      On August 8, Air China, China Eastern Airlines, Shanghai Airlines, Xiamen Airlines signed the final Purchase agreement of 42 Boeing planes with Boeing. The price in catalogue is US$5.04 billion. The first plane will be delivered in 2008.……

  14. International collaboration in SSC (or any $4 billion scientific project)

    International Nuclear Information System (INIS)

    In this paper, the author discusses the superconducting supercollider. This is a project that costs U.S. $4.4 billion. The author spends a short time giving the motivation (which is a scientific motivation) and also giving the idea of how it is possible, with U.S. deficits

  15. Vision Loss in Older Adults.

    Science.gov (United States)

    Pelletier, Allen L; Rojas-Roldan, Ledy; Coffin, Janis

    2016-08-01

    Vision loss affects 37 million Americans older than 50 years and one in four who are older than 80 years. The U.S. Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for impaired visual acuity in adults older than 65 years. However, family physicians play a critical role in identifying persons who are at risk of vision loss, counseling patients, and referring patients for disease-specific treatment. The conditions that cause most cases of vision loss in older patients are age-related macular degeneration, glaucoma, ocular complications of diabetes mellitus, and age-related cataracts. Vitamin supplements can delay the progression of age-related macular degeneration. Intravitreal injection of a vascular endothelial growth factor inhibitor can preserve vision in the neovascular form of macular degeneration. Medicated eye drops reduce intraocular pressure and can delay the progression of vision loss in patients with glaucoma, but adherence to treatment is poor. Laser trabeculoplasty also lowers intraocular pressure and preserves vision in patients with primary open-angle glaucoma, but long-term studies are needed to identify who is most likely to benefit from surgery. Tight glycemic control in adults with diabetes slows the progression of diabetic retinopathy, but must be balanced against the risks of hypoglycemia and death in older adults. Fenofibrate also slows progression of diabetic retinopathy. Panretinal photocoagulation is the mainstay of treatment for diabetic retinopathy, whereas vascular endothelial growth factor inhibitors slow vision loss resulting from diabetic macular edema. Preoperative testing before cataract surgery does not improve outcomes and is not recommended. PMID:27479624

  16. Complications and clinical outcomes of minimally invasive transforaminal lumbar interbody fusion for the treatment of one- or two-level degenerative disc diseases of the lumbar spine in patients older than 65 years

    Institute of Scientific and Technical Information of China (English)

    WU Wen-jian; LIANG Yu; ZHANG Xin-kai; CAO Peng; ZHENG Tao

    2012-01-01

    Background Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has been successfully used to treat degenerative diseases of the lumbar spine.There are few reports comparing the complications and clinical outcomes in older patients who have undergone one- or two-level MIS-TLIF with those of younger patients.The aim of this study was to investigate the clinical outcomes of MIS-TLIF in the treatment of degenerative disc disease of lumbar spine of the patients older than 65 years,with an emphasis on perioperative complications compared to the younger patients.Methods One hundred and fifty-one consecutive cases of one- or two-level degenerative disc disease of lumbar spine treated with MIS-TLIF were reviewed for the radiological and clinical outcomes.They were divided into elderly group (age ≥65 years old) and younger group (age <65 years old),and were followed for at least 6 months.Radiographs were obtained before and after surgery,3 months postoperatively,and at the final follow-up to determine the presence of fusion,hardware-related problems.The clinical outcomes were evaluated using the Oswestry Disability Index (ODI)before and after surgery,and at the final follow-up.The visual analogue scale (VAS) score of back and leg pain were evaluated as well.The intra-operative data and peri-operative complications were recorded.Results The mean age of these patients at operation was (57.7±14.2) years (range 26-82 years).Of 151 patients,62were 65 years or older.The elderly patients had more comorbidities and more porportion of lumbar canal stenosis.The overall fusion rate was 88.4% at the final follow-up,with no significant difference between younger and elderly patients.The ODI,the VAS of back pain and radicular pain of both young and elderly group were significantly improved aftersurgery and at the final follow-up,without significant difference between two groups.There were 16 complications with an incidence of 10.6%,including 7 major complications

  17. Cognitive characteristics of older Japanese drivers

    Directory of Open Access Journals (Sweden)

    Susilowati Indri H

    2012-02-01

    Full Text Available Abstract Background Some causes of accidents among older drivers are: not paying attention to traffic signals; missing stop lines; and having to deal with and misjudging emergency situations. These causes of accidents reveal problems with attention and cognition. Such incidents are also related to driver perception and stress-coping mechanisms. It is important to examine the relation of stress reactions to attention and cognition as a factor influencing the causes of accidents commonly involving older drivers. Finding Subjects were 10 young drivers (23.3 ± 3.33 years and 25 older drivers divided into two groups (older1 [60 to 65 years] and older2 [> 65 years]. This study revealed the correlation within driver stress inventory and driver coping questionnaires parameters was observed only in older drivers. They also needed a longer response time for Trail Making Test A and B. The factors affected the attention and cognition of older drivers by age but not driving experience itself, and coping parameters such as emotion focus, reappraisal, and avoidance were not included as stress inventory parameters. Being prone to fatigue was less for younger drivers than older drivers. Because they have shorter distances, shorter drive times, and no need for expressways, older drivers also had a significantly lower risk of thrill-seeking behaviour and more patience. Conclusion The intervention addressing their attention skills, aggressive feelings, and emotion focus should be considered. The technological improvements in cars will make older drivers feel safer and make driving easier which might lower the attention paid to the road, and regular driving training might be needed to assess and enhance their safety.

  18. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

    DEFF Research Database (Denmark)

    Inzitari, Domenico; Pracucci, Giovanni; Poggesi, Anna; Carlucci, Giovanna; Barkhof, Frederik; Chabriat, Hugues; Erkinjuntti, Timo; Fazekas, Franz; Ferro, José M; Hennerici, Michael; Langhorne, Peter; O'Brien, John; Scheltens, Philip; Visser, Marieke C; Wahlund, Lars-Olof; Waldemar, Gunhild; Wallin, Anders; Pantoni, Leonardo

    2009-01-01

    rank test P<0.001). In a Cox model comparing severe with mild changes and adjusted for clinical factors of functional decline, the risk of transition to disability or death was more than twofold higher (hazard ratio 2.36, 95% confidence interval 1.65 to 3.81). The other predictors were age group......, history of atrial fibrillation, and complaint of gait disturbances. The effect of severe changes remained significant independently of baseline degree of atrophy and number of infarcts. Incident stroke and dementia only slightly modified this effect. CONCLUSION: The three year results of the LADIS study...

  19. Relation between clinical depression risk and physical activity and time spent watching television in older women: a 10-year prospective follow-up study.

    Science.gov (United States)

    Lucas, Michel; Mekary, Rania; Pan, An; Mirzaei, Fariba; O'Reilly, Eilis J; Willett, Walter C; Koenen, Karestan; Okereke, Olivia I; Ascherio, Alberto

    2011-11-01

    Although physical activity (PA) has been inversely associated with depressive symptoms, it is not clear whether regular PA and television watching are associated with clinical depression risk. The authors conducted a prospective analysis involving 49,821 US women from the Nurses' Health Study who were free from depressive symptoms at baseline (1996). Information on PA was obtained from validated questionnaires completed in 1992, 1994, 1996, 1998, and 2000; analyses were conducted using the cumulative average of PA (minutes/day) with a 2-year latency period applied. Participants were asked about television-watching habits in 1992. Cox proportional hazards regression models adjusted for multiple risk factors were used to estimate relative risks of clinical depression (self-reported physician-diagnosed depression or use of antidepressants). During 10 years of follow-up (1996-2006), 6,505 incident cases of depression were documented. Higher levels of PA were associated with lower depression risk. The multivariate relative risk comparing the highest level of PA (≥ 90 minutes/day) with the lowest (confidence interval: 0.70, 0.92; P(trend) women who spent 21 hours/week or more watching television with those who spent 0-1 hour/week was 1.13 (95% confidence interval: 1.00, 1.27; P(trend) = 0.01). Analyses simultaneously considering PA and television watching suggested that both contributed independently to depression risk. PMID:21984659

  20. Relationship between serum ferritin levels and sarcopenia in Korean females aged 60 years and older using the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3, 2008-2009.

    Directory of Open Access Journals (Sweden)

    Tae Ho Kim

    Full Text Available CONTEXT: It has been suggested that elevated serum ferritin is associated with several metabolic disorders. However, there is no reported study assessing any association between serum ferritin and sarcopenia despite the close relationship between sarcopenia and metabolic disorders. OBJECTIVE: We investigated whether serum ferritin was associated with sarcopenia in older Koreans. DESIGN AND SETTING: We conducted a cross-sectional study based on data acquired in the second and third years (2008-9 of the fourth Korean National Health and Nutrition Examination Survey. PARTICIPANTS: In total, 952 men (mean age 69.0 years and 1,380 women (mean age 69.3 years aged 60 years and older completed a body composition study using dual energy X-ray absorptiometry. MEASUREMENTS: Serum ferritin levels were measured. Sarcopenia was defined as an appendicular skeletal mass as a percentage of body weight that was less than two standard deviations below the gender-specific mean for young adults. RESULTS: Serum ferritin levels were lower in women than in men. Women with sarcopenia showed a higher level of serum ferritin than women without sarcopenia (men: without sarcopenia 115.7 ng/mL and with sarcopenia 134.4 ng/mL vs. women: without sarcopenia 70.7 ng/mL and with sarcopenia 85.4 ng/mL. The prevalence of sarcopenia increased as the tertile of serum ferritin increased. However, statistical significance was only seen in elderly women (1(st tertile 6.3%, 2(nd tertile 8.0%, 3(rd tertile 12.0%; p = 0.008. Without adjustment, compared with those in the lowest tertile of serum ferritin level, participants in the highest tertile had an odds ratio of 2.02 (95% confidence interval = 1.26-3.23 for sarcopenia in women. After adjusting for known risk factors, the OR for sarcopenia was 1.74 (95% CI = 1.02-2.97 in women. There was no statistically significant association between sarcopenia and serum ferritin tertiles in men. CONCLUSIONS: Elevated serum ferritin levels were

  1. Clinical impact of postprogression survival for overall survival in elderly patients (aged 75 years or older with advanced nonsmall cell lung cancer

    Directory of Open Access Journals (Sweden)

    Reiko Yoshino

    2015-01-01

    Full Text Available Introduction: The effects of first-line single-agent chemotherapy on overall survival (OS might be confounded by subsequent treatments in elderly patients with nonsmall cell lung cancer (NSCLC. We, therefore, aimed to evaluate whether progression-free survival (PFS, postprogression survival (PPS, or tumor response might be a valid surrogate endpoint for OS in this patient population. Patients and Methods: We retrospectively reviewed the clinical data of 58 elderly patients with advanced NSCLC, who received first-line single-agent cytotoxic chemotherapy at our institution between October 2003 and November 2013. The relationships of PFS, PPS, and tumor response with OS were individually analyzed. Results: The study cohort included 46 men and 12 women with a median age of 79 years (range: 75-87 years. There were 30 adenocarcinomas, 22 squamous cell carcinomas, and 6 other histologic types with 1 stage IIIA, 9 IIIB, and 48 IV cases. The performance status (PS scores were 0, 1, and 2 in 18, 35, and 5 patients, respectively. The median PFS and OS were 2.8 and 5.4 months, respectively. Our analyses revealed a strong correlation of PPS and PFS with OS, whereas that between tumor shrinkage and OS was weak. Tumor stage and PS after initial treatment were significantly associated with PPS. Individual analysis indicated that PPS might serve as a surrogate for OS in elderly patients with advanced NSCLC receiving first-line single-agent chemotherapy. Conclusion: Our findings suggested that the disease course after progression following first-line single-agent chemotherapy might influence the OS of elderly patients with advanced NSCLC.

  2. A 17-billion-solar-mass black hole in a group galaxy with a diffuse core.

    Science.gov (United States)

    Thomas, Jens; Ma, Chung-Pei; McConnell, Nicholas J; Greene, Jenny E; Blakeslee, John P; Janish, Ryan

    2016-04-21

    Quasars are associated with and powered by the accretion of material onto massive black holes; the detection of highly luminous quasars with redshifts greater than z = 6 suggests that black holes of up to ten billion solar masses already existed 13 billion years ago. Two possible present-day 'dormant' descendants of this population of 'active' black holes have been found in the galaxies NGC 3842 and NGC 4889 at the centres of the Leo and Coma galaxy clusters, which together form the central region of the Great Wall--the largest local structure of galaxies. The most luminous quasars, however, are not confined to such high-density regions of the early Universe; yet dormant black holes of this high mass have not yet been found outside of modern-day rich clusters. Here we report observations of the stellar velocity distribution in the galaxy NGC 1600--a relatively isolated elliptical galaxy near the centre of a galaxy group at a distance of 64 megaparsecs from Earth. We use orbit superposition models to determine that the black hole at the centre of NGC 1600 has a mass of 17 billion solar masses. The spatial distribution of stars near the centre of NGC 1600 is rather diffuse. We find that the region of depleted stellar density in the cores of massive elliptical galaxies extends over the same radius as the gravitational sphere of influence of the central black holes, and interpret this as the dynamical imprint of the black holes. PMID:27049949

  3. Prevalence and Predictors of Pre-Diabetes and Diabetes among Adults 18 Years or Older in Florida: A Multinomial Logistic Modeling Approach.

    Directory of Open Access Journals (Sweden)

    Ifechukwude Obiamaka Okwechime

    Full Text Available Individuals with pre-diabetes and diabetes have increased risks of developing macro-vascular complications including heart disease and stroke; which are the leading causes of death globally. The objective of this study was to estimate the prevalence of pre-diabetes and diabetes, and to investigate their predictors among adults ≥18 years in Florida.Data covering the time period January-December 2013, were obtained from Florida's Behavioral Risk Factor Surveillance System (BRFSS. Survey design of the study was declared using SVYSET statement of STATA 13.1. Descriptive analyses were performed to estimate the prevalence of pre-diabetes and diabetes. Predictors of pre-diabetes and diabetes were investigated using multinomial logistic regression model. Model goodness-of-fit was evaluated using both the multinomial goodness-of-fit test proposed by Fagerland, Hosmer, and Bofin, as well as, the Hosmer-Lemeshow's goodness of fit test.There were approximately 2,983 (7.3% and 5,189 (12.1% adults in Florida diagnosed with pre-diabetes and diabetes, respectively. Over half of the study respondents were white, married and over the age of 45 years while 36.4% reported being physically inactive, overweight (36.4% or obese (26.4%, hypertensive (34.6%, hypercholesteremic (40.3%, and 26% were arthritic. Based on the final multivariable multinomial model, only being overweight (Relative Risk Ratio [RRR] = 1.85, 95% Confidence Interval [95% CI] = 1.41, 2.42, obese (RRR = 3.41, 95% CI = 2.61, 4.45, hypertensive (RRR = 1.69, 95% CI = 1.33, 2.15, hypercholesterolemic (RRR = 1.94, 95% CI = 1.55, 2.43, and arthritic (RRR = 1.24, 95% CI = 1.00, 1.55 had significant associations with pre-diabetes. However, more predictors had significant associations with diabetes and the strengths of associations tended to be higher than for the association with pre-diabetes. For instance, the relative risk ratios for the association between diabetes and being overweight (RRR = 2.00, 95

  4. Comparison of Angiography Findings in Iranian Patients Younger and Older Than 50 Years Underwent Coronary Angiography in Boo-Ali Hospital: A Cross-sectional Study

    Directory of Open Access Journals (Sweden)

    Moshar

    2016-01-01

    Full Text Available Background Coronary artery disease (CAD or ischemic heart disease (IHD is the most common cause of death globally. CAD is a multifactorial disease with many variable risk factors. It is estimated that its prevalence is increasing in various populations. CAD in young adults is also increasing in Iran due to the life style changes. Identifying risk factors and timely correction can reduce the burden of disease and related health problems. Objectives To evaluate the prevalence of CAD and the traditional risk factors according to angiographic findings of patient’s ≤ 50 and > 50 years old. Patients and Methods This is a cross sectional descriptive study on 112 patients who were admitted to Boo-Ali hospital from November 2013 to December 2014 for evaluation of CAD. Self-administered questionnaire consisted of demographic data and risk factors were filled. Angiographic film was reviewed in respect to coronary arteries involvement and echocardiography was performed. For evaluation of left ventricular (LV function, patients divided into two groups of ages ≤ 50 (group A and > 50 (group B years old. Risk factors, coronary angiography and ejection fraction (EF were compared. Results Of the 112 patients, 51 (45.5% were in group A and 61 (54.5% were in group B with mean age of 37.6 ± 4.4 and 63 ± 8.5, respectively. No significant statistical differences were found between the body mass index (BMI, smoking, family history (FH, hyperlipidemia (HLP and diabetes mellitus type 2 (DM2 between two groups (P > 0.05. Hypertension (HTN was significantly higher in group B vs. group A respect to 65.6% and 31.4% (P 0.05. There were a significant higher number of patients with a decline in EF in group B (P = 0.01. Conclusions The pattern and number of vessels involved were similar in both groups. Based on common prevalence of traditional risk factors among two groups, planning for lifestyle changes is recommended.

  5. The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994–2006

    Directory of Open Access Journals (Sweden)

    Liu Y

    2014-01-01

    Full Text Available Yong Liu,1 Janet B Croft,1 Lynda A Anderson,2 Anne G Wheaton,1 Letitia R Presley-Cantrell,3 Earl S Ford11Epidemiology and Surveillance Branch, 2Healthy Aging Program, Division of Population Health, CDC and Rollins School of Public Health, Emory University, 3Program Development and Services Management, Division of Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USAPurpose: To assess associations among chronic obstructive pulmonary disease (COPD, disability as measured by activities of daily living (ADL and instrumental ADL (IADL, engagement in social activities, and death among elderly noninstitutionalized US residents.Materials and methods: A nationally representative sample of 9,415 adults who were aged ≥70 years and responded to the Second Supplement on Aging survey in 1994–1996 and mortality follow-up study through 2006 were assessed. Multiple logistic regression analyses were performed to assess the risk of all-cause mortality in participants with COPD after accounting for age, sex, race/ethnicity, and smoking status.Results: At baseline, approximately 9.6% of study participants reported having COPD. Compared with participants without COPD, those with COPD were significantly more likely (P<0.05 to have difficulty with at least one ADL (44.3% versus [vs] 27.5% and with at least one IADL (59.9% vs 40.2%, significantly less likely to be engaged in social activities (32.6% vs 26.3%, and significantly more likely to die by 2006 (70.7% vs 60.4%; adjusted risk ratio 1.15, P<0.05. The association between COPD and risk for death was moderately attenuated by disability status.Conclusion: COPD is positively associated with disability and mortality risk among US adults aged ≥70 years. The significant relationship between COPD and mortality risk was moderately attenuated, but was not completely explained by stages of ADL and IADL limitations and social activities.Keywords: chronic obstructive pulmonary

  6. Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial.

    Science.gov (United States)

    Meattini, Icro; Saieva, Calogero; Marrazzo, Livia; Di Brina, Lucia; Pallotta, Stefania; Mangoni, Monica; Meacci, Fiammetta; Bendinelli, Benedetta; Francolini, Giulio; Desideri, Isacco; De Luca Cardillo, Carla; Scotti, Vieri; Furfaro, Ilaria Francesca; Rossi, Francesca; Greto, Daniela; Bonomo, Pierluigi; Casella, Donato; Bernini, Marco; Sanchez, Luis; Orzalesi, Lorenzo; Simoncini, Roberta; Nori, Jacopo; Bianchi, Simonetta; Livi, Lorenzo

    2015-10-01

    The purpose of this study was to report the efficacy and the safety profile on the subset of selected early breast cancer (BC) patients aged 70 years or older from a single-center phase 3 trial comparing whole breast irradiation (WBI) to accelerated partial breast irradiation (APBI) using intensity-modulated radiation therapy technique. Between 2005 and 2013, 520 patients aged more than 40 years old were enrolled and randomly assigned to receive either WBI or APBI in a 1:1 ratio. Eligible patients were women with early BC (maximum diameter 2.5 cm) suitable for breast conserving surgery. This study is registered with ClinicalTrials.gov, NCT02104895. A total of 117 patients aged 70 years or more were analyzed (58 in the WBI arm, 59 in the APBI arm). At a median follow-up of 5-years (range 3.4-7.0), the ipsilateral breast tumor recurrence (IBTR) rate was 1.9 % in both groups. No significant difference between the two groups was identified (log-rank test p = 0.96). The 5-year disease-free survival (DFS) rates in the WBI group and APBI group were 6.1 and 1.9 %, respectively (p = 0.33). The APBI group presented significantly better results in terms of acute skin toxicity, considering both any grade (p = 0.0001) and grade 2 or higher (p = 0.0001). Our subgroup analyses showed a very low rate and no significant difference in terms of IBTR, using both WBI and APBI. A significant impact on patients compliance in terms of acute and early late toxicity was shown, which could translate in a consistent improvement of overall quality of life. PMID:26350524

  7. Tendances Carbone no. 75 'The CDM: let's not discard a tool that raised over US$ 200 billion'

    International Nuclear Information System (INIS)

    Among the publications of CDC Climat Research, 'Tendances Carbone' bulletin specifically studies the developments of the European market for CO2 allowances. This issue addresses the following points: Everyone wonders which miraculous instrument will enable the Green Climate Fund to mobilize the pledged US$100 billion per year in climate finance by 2020. Developing countries are now asking for interim targets to quench their mounting skepticism that this level of commitment can be reached. In the meantime paradoxically, the Clean Development Mechanism (CDM) - a tool that managed to leverage over US$200 billion of mostly private investment for climate change mitigation - is left dying without much regret

  8. RCT of a theory-based intervention promoting healthy eating and physical activity amongst out-patients older than 65 years.

    Science.gov (United States)

    Kelley, Kate; Abraham, Charles

    2004-08-01

    A randomised controlled trial was used to evaluate a theory-based health promotion intervention. The intervention, a healthy living booklet, was designed to promote healthy eating and physical activity amongst people aged over 65 years attending hospital out-patient clinics. The booklet employed persuasive arguments targeting the most proximal cognitive antecedents of behaviour specified by the theory of planned behaviour, as well as goal setting prompts. Participants (N = 252, average age=82) were randomly allocated to a control (patient satisfaction questionnaire) or intervention (healthy living booklet) group. Cognitions and behaviour were measured pre-intervention and at a two week follow up. The intervention group made significantly higher gains in perceived behavioural control, intention and behaviour for both target behaviours, suggesting that the intervention was successful. Sixty three of those invited to set goals to eat more healthily (e.g., "to eat five portions of fruit and vegetables a day") did so, and 67% of those who set such goals reported 100% success in acting on them. By contrast, only 34% of intervention participants set an activity goal (e.g., "a five minute walk everyday"), and only 51% reported 100% success in enacting these goals. Results suggest that the observed behavioural effects of the healthy eating booklet could be attributed to goal setting as well as changes in perceived behavioural control and intention. PMID:15177835

  9. The Association between the Consumption of Fish/Shellfish and the Risk of Osteoporosis in Men and Postmenopausal Women Aged 50 Years or Older

    Directory of Open Access Journals (Sweden)

    Eunjin Choi

    2016-02-01

    Full Text Available Fish rich in n-3 polyunsaturated fatty acids have been suggested to have a favorable effect on bone health, but previous epidemiologic studies have shown inconsistent results. The purpose of the present study was to investigate the hypothesis that the consumption of fish and shellfish is positively associated with bone mass and negatively associated with the risk of osteoporosis in Koreans and Americans. Men and postmenopausal women ≥50 years old from the Korean National Health and Nutrition Examination Survey 2008–2011 (n = 7154 and the National Health and Nutrition Examination Survey 2007–2010 (n = 2658 were included. There was a positive correlation between the consumption of fish and shellfish and bone mineral density (BMD of the total femur, femoral neck, and lumbar spine in Koreans. Consistently, multivariate logistic regression analysis showed a significant association between intake of fish and shellfish and the risk of osteoporosis in Koreans but not in Americans. Consumption of fish and shellfish was 4–5 times higher in Koreans than Americans in the present study. In conclusion, intake of fish and shellfish was associated with BMD and the risk of osteoporosis in Koreans but not in Americans, suggesting that a minimum intake level of fish and shellfish might be recommended to protect against bone loss and osteoporosis.

  10. Does multicomponent physical exercise with simultaneous cognitive training boost cognitive performance in older adults? A 6-month rando­mized controlled trial with a 1-year follow-up

    Directory of Open Access Journals (Sweden)

    Eggenberger P

    2015-08-01

    Full Text Available Patrick Eggenberger,1 Vera Schumacher,2,3 Marius Angst,1 Nathan Theill,4,5 Eling D de Bruin1,6,7 1Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, 2Department of Gerontopsychology and Gerontology, 3University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Zurich, 4Division of Psychiatry Research, University of Zurich, Schlieren, 5Center for Gerontology, University of Zurich, Zurich, Switzerland; 6CAPHRI School for Public Health and Primary Care, Department of Epidemiology, 7Centre for Evidence Based Physiotherapy, Maastricht University, Maastricht, the Netherlands Background: Cognitive impairment is a health problem that concerns almost every second elderly person. Physical and cognitive training have differential positive effects on cognition, but have been rarely applied in combination. This study evaluates synergistic effects of multicomponent physical exercise complemented with novel simultaneous cognitive training on cognition in older adults. We hypothesized that simultaneous cognitive–physical components would add training specific cognitive benefits compared to exclusively physical training.Methods: Seniors, older than 70 years, without cognitive impairment, were randomly assigned to either: 1 virtual reality video game dancing (DANCE, 2 treadmill walking with simultaneous verbal memory training (MEMORY, or 3 treadmill walking (PHYS. Each program was complemented with strength and balance exercises. Two 1-hour training sessions per week over 6 months were applied. Cognitive performance was assessed at baseline, after 3 and 6 months, and at 1-year follow-up. Multiple regression analyses with planned comparisons were calculated.Results: Eighty-nine participants were randomized to the three groups initially, 71 completed the training, while 47 were available at 1-year follow-up. Advantages of the simultaneous cognitive–physical programs were

  11. Medications and Older Adults

    Science.gov (United States)

    ... older adults and often require the use of antihistamines. Antihistamines are divided into two classes: first generation antihistamines and second generation antihistamines. First generation antihistamines, while ...

  12. Normal Values of the Maximal Respiratory Pressures in Healthy People Older than 20 Years Old in the City of Manizales – Colombia

    Directory of Open Access Journals (Sweden)

    Lida Maritza Gil Obando

    2012-06-01

    Full Text Available The Maximal Inspiratory Pressure (MIP and Maximal Expiratory Pressure (MEP are global measures of the maximal strength of the respiratory muscles. Objectives :To determine the values of MIP and MEP in healthy subjects aged 20 years old from the urban area of Maniza­les, Colombia and to correlate them with sociodemographic and anthropometric variables. Methods: This is an observational descriptive study. The population of the study was 203.965 healthy people from Ma­nizales, a Colombian city located at 2150 meters above sea level. The sample size was 308 subjects, selected using simple random sampling. The maximal respiratory pressures were determined in the sample chosen and were then considered according to the variables of age, gender, size, weight, Body Mass Index (BMI, and BMI classification. Finally a predictive model was created. Results: The average MIP value among the subjects of the study was 75±27cmH20 and the MEP value was 96.4±36cmH20. Both averages were higher in men than in women. Predictive equations were established for the normal values of MIP and MEP in healthy subjects; the best model for MIP was the resultant one among age, gender and BMI classification and for the MEP among gender, weight and height. Conclusion: Maximal respiratory pressure values were lower among the population of Manizales than those found in in­ternational studies. Gender and anthropometric characteristics (weight, height and BMI classification are the explanatory variables that better support the average values of MIP and MEP in the predictive models proposed. 14.00 800x600 Normal 0 21 false false false ES-CO X-NONE X-NONE MicrosoftInternetExplorer4

  13. Identifying the Poorest Older Americans

    OpenAIRE

    Fisher, Johathan; Johnson, David; Marchand, Joseph; Smeeding, Timothy; Boyle Torrey, B.

    2009-01-01

    Objectives: Public policies generally target a subset of the population defined as poor or needy, but rarely are people poor or needy in the same way. This is particularly true among older adults, as they have fewer options to compensate for financial decisions made earlier in life. This study investigates poverty among this group in order to identify who among them is financially worst off. Methods: We use 20 years of data from the Consumer Expenditure Survey to examine the income and consum...

  14. Cost of solving mysteries of universe: $6.7 billion

    CERN Multimedia

    Overbye, Dennis

    2007-01-01

    "An international consortium of physicists on Thursday released the first detailed design of what they believe will be the next big thing in physics. The machine, 20 miles long, will slam together electrons and their opposites, positrons, to produce fireballs of energy re-creating conditions when the universe was only a trillionth of a second old. It would cost about $6.7 billion." (1 page)

  15. Oxytocin improves emotion recognition for older males.

    Science.gov (United States)

    Campbell, Anna; Ruffman, Ted; Murray, Janice E; Glue, Paul

    2014-10-01

    Older adults (≥60 years) perform worse than young adults (18-30 years) when recognizing facial expressions of emotion. The hypothesized cause of these changes might be declines in neurotransmitters that could affect information processing within the brain. In the present study, we examined the neuropeptide oxytocin that functions to increase neurotransmission. Research suggests that oxytocin benefits the emotion recognition of less socially able individuals. Men tend to have lower levels of oxytocin and older men tend to have worse emotion recognition than older women; therefore, there is reason to think that older men will be particularly likely to benefit from oxytocin. We examined this idea using a double-blind design, testing 68 older and 68 young adults randomly allocated to receive oxytocin nasal spray (20 international units) or placebo. Forty-five minutes afterward they completed an emotion recognition task assessing labeling accuracy for angry, disgusted, fearful, happy, neutral, and sad faces. Older males receiving oxytocin showed improved emotion recognition relative to those taking placebo. No differences were found for older females or young adults. We hypothesize that oxytocin facilitates emotion recognition by improving neurotransmission in the group with the worst emotion recognition. PMID:24856057

  16. Treatment of periodontal disease in older adults.

    Science.gov (United States)

    Renvert, Stefan; Persson, G Rutger

    2016-10-01

    Within the next 40 years the number of older adults worldwide will more than double. This will impact periodontal treatment needs and presents a challenge to health-care providers and governments worldwide, as severe periodontitis has been reported to be the sixth most prevalent medical condition in the world. Older adults (≥ 80 years of age) who receive regular dental care retain more teeth than those who do not receive such care, but routine general dental care for these individuals is not sufficient to prevent the progression of periodontitis with the same degree of success as in younger individuals. There is a paucity of data on the efficacy of different periodontal therapies for older individuals. However, considering the higher prevalence of chronic medical conditions seen in older adults, it cannot be assumed that periodontal therapy will yield the same degree of success seen in younger individuals. Furthermore, medications can influence the status of the periodontium and the delivery of periodontal care. As an example, anticoagulant drugs are common among older patients and may be a contraindication to certain treatments. Newer anticoagulants will, however, facilitate surgical intervention in older patients. Furthermore, prescription medications taken for chronic conditions, such as osteoporosis and cardiovascular diseases, can affect the periodontium in a variety of ways. In summary, consideration of socio-economic factors, general health status and multiple-drug therapies will, in the future, be an important part of the management of periodontitis in older adults. PMID:27501494

  17. Perceived age discrimination in older adults

    OpenAIRE

    Rippon, Isla; Kneale, Dylan; de Oliveira, Cesar; Demakakos, Panayotes; Steptoe, Andrew

    2013-01-01

    Objectives: to examine perceived age discrimination in a large representative sample of older adults in England. Methods: this cross-sectional study of over 7,500 individuals used data from the fifth wave of the English Longitudinal Study of Ageing (ELSA), a longitudinal cohort study of men and women aged 52 years and older in England. Wave 5 asked respondents about the frequency of five everyday discriminatory situations. Participants who attributed any experiences of discrimination to their...

  18. Managing Status Epilepticus in the Older Adult

    OpenAIRE

    Stephane Legriel; Brophy, Gretchen M.

    2016-01-01

    The aim of this systematic review was to describe particularities in epidemiology, outcome, and management modalities in the older adult population with status epilepticus. There is a higher incidence of status epilepticus in the older adult population, and it commonly has a nonconvulsive presentation. Diagnosis in this population may be difficult and requires an unrestricted use of EEG. Short and long term associated-mortality are high, and age over 60 years is an independent factor associat...

  19. Multicomponent physical exercise with simultaneous cognitive training to enhance dual-task walking of older adults: a secondary analysis of a 6-month randomized controlled trial with 1-year follow-up

    Directory of Open Access Journals (Sweden)

    Eggenberger P

    2015-10-01

    Full Text Available Patrick Eggenberger,1 Nathan Theill,2,3 Stefan Holenstein,1 Vera Schumacher,4,5 Eling D de Bruin1,6,7 1Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, 2Division of Psychiatry Research, 3Center for Gerontology, 4Department of Gerontopsychology and Gerontology, 5University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Zurich, Switzerland; 6Department of Epidemiology, CAPHRI School for Public Health and Primary Care, 7Centre for Evidence Based Physiotherapy, Maastricht University, Maastricht, the Netherlands Background: About one-third of people older than 65 years fall at least once a year. Physical exercise has been previously demonstrated to improve gait, enhance physical fitness, and prevent falls. Nonetheless, the addition of cognitive training components may potentially increase these effects, since cognitive impairment is related to gait irregularities and fall risk. We hypothesized that simultaneous cognitive–physical training would lead to greater improvements in dual-task (DT gait compared to exclusive physical training.Methods: Elderly persons older than 70 years and without cognitive impairment were randomly assigned to the following groups: 1 virtual reality video game dancing (DANCE, 2 treadmill walking with simultaneous verbal memory training (MEMORY, or 3 treadmill walking (PHYS. Each program was complemented with strength and balance exercises. Two 1-hour training sessions per week over 6 months were applied. Gait variables, functional fitness (Short Physical Performance Battery, 6-minute walk, and fall frequencies were assessed at baseline, after 3 months and 6 months, and at 1-year follow-up. Multiple regression analyses with planned comparisons were carried out.Results: Eighty-nine participants were randomized to three groups initially; 71 completed the training and 47 were available at 1-year follow-up. DANCE/MEMORY showed a

  20. Low-Dose lnterleukin-2 Immunotherapy Does Not Improve Outcome of Patients Age 60 Years and Older with Acute Myeloid Leukemia in First Complete Remission%首次缓解后使用小剂量IL-2免疫治疗不能改善≥60岁老年急性髓性白血病患者预后

    Institute of Scientific and Technical Information of China (English)

    马军; 吴穗晶; 杜欣

    2009-01-01

    @@ 1文献来源 Low-dose Interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720. [J]. J Clin Oncol, 2008,12(26):4934-4939.

  1. Alcohol, tabaco y deterioro cognoscitivo en adultos mexicanos mayores de 65 años Cognitive impairment and alcohol and cigarette consumption in Mexican adults older than 65 years

    Directory of Open Access Journals (Sweden)

    Sara Gloria Aguilar-Navarro

    2007-01-01

    Full Text Available OBJETIVO: Conocer la prevalencia del consumo de alcohol y tabaco y su asociación con deterioro cognoscitivo en la población mexicana mayor de 65 años. MATERIAL Y MÉTODOS: Se incluyeron 4 872 mayores de 65 años en la muestra del Estudio Nacional sobre Salud y Envejecimiento en México (ENASEM 2001. Se interrogó sobre el consumo de alcohol y tabaco. Para la clasificación de los sujetos con deterioro cognoscitivo, se utilizó la escala total de los diferentes dominios cognoscitivos. Se aplicaron ji cuadrada, Mann Whitney U y regresión logística para encontrar asociaciones. RESULTADOS: La prevalencia de alcoholismo según CAGE fue de 2.8% y la del consumo de tabaco de 14 por ciento. Factores asociados con el consumo de alcohol: edad 65-69 años (p OBJECTIVE: To determine the prevalence of the consumption of alcohol and cigarette smoking and their association with cognitive impairment among older Mexican adults. MATERIAL AND METHODS: A total of 4 872 people over 65 years of age included in the sample of the National Mexican Health and Aging Study carried out in 2001 were questioned about their consumption of alcohol and cigarette smoking. For the classification of those subjects with cognitive impairment, the total scale of the different cognitive domains was used. The chi-square, Mann-Whitney U test, and logistical regression were used in order to find associations. RESULTS: The prevalence of alcoholism according to CAGE was 2.8% and the prevalence of the consumption of cigarette smoking was 14%. Factors associated with the consumption of alcohol were:age 65-69 (p <0.001, men (RR 3.17,p <0.001, and high level of education (p <0.001. The association between the consumption of alcohol and cognitive impairment (X2=6.59, p <0.01 was statistically significant. CONCLUSIONS: The prevalence of consumption of alcohol and cigarette smoking in older Mexican adults are similar to that reported in other countries; the consumption of alcohol and its

  2. Billion particle linac simulations for future light sources

    International Nuclear Information System (INIS)

    In this paper we report on multi-physics, multi-billion macroparticle simulation of beam transport in a free electron laser (FEL) linac for future light source applications. The simulation includes a self-consistent calculation of 3D space-charge effects, short-range geometry wakefields, longitudinal coherent synchrotron radiation (CSR) wakefields, and detailed modeling of RF acceleration and focusing. We discuss the need for and the challenges associated with such large-scale simulation. Applications to the study of the microbunching instability in an FEL linac are also presented

  3. Developing economic environment: energy for a billion people

    International Nuclear Information System (INIS)

    The ongoing reforms in the Indian economy provide an interesting canvas for optimal development of the energy sector serving the needs for a billion people. It will be necessary in the global interest, to avoid the pitfalls of developing an energy intensive society as in the west and remain within the realms of sustainable development. It also deals with the strategies to be adopted for energy conservation, rehabilitation of existing plants and optimal utilisation of hydro thermal capacities by integrated grid operation on a commercial basis and setting up of pumped storage plants. 9 tabs

  4. Older people without children

    OpenAIRE

    Reynolds, Jill

    2009-01-01

    In a recent discussion about government proposals on care for older people (July 2009), the Radio 4 news presenter referred to a possible need to return to the attitude that it's the family's responsibility to look after its older members. Yet there is often already an expectation that the family – by which is usually meant children or grandchildren – can be relied upon to take an active part in the social life and any care arrangements for their older members. Indeed, social policy in much o...

  5. Cycling strategies of young and older cyclists.

    Science.gov (United States)

    Bulsink, Vera E; Kiewiet, Hielke; van de Belt, Dorien; Bonnema, G Maarten; Koopman, Bart

    2016-04-01

    This study concentrates on the cycling strategies of older cyclists (54-62year olds) in comparison to young cyclists (20-30year olds). While cycling in a safe laboratory set-up, controlled lateral perturbations are applied to the rear of the bicycle. Three possible strategies to keep balance are analysed for a young and older aged group: steering, lateral trunk movement and outward knee movement. Older subjects appear to rely more on knee movement as a control mechanism than young subjects. Furthermore, the frequency domain analysis revealed that the older adults need more effort to counteract high frequency perturbations. Increased inter-individual variation for the older adults subject group suggests that this group can be seen as a transition group in terms of physical fitness. This explains their increased risk in single-sided bicycle accidents (i.e. accidents involving the cyclist only). Therefore, older cyclists could benefit from improving the stability of cycling at lower speeds. PMID:26796419

  6. How Active Are Older Americans?

    Directory of Open Access Journals (Sweden)

    Judy Kruger, PhD

    2007-07-01

    Full Text Available IntroductionRegular physical activity can reduce age-related functional decline, as well people’s risk for chronic diseases such as coronary heart disease, hypertension, colon cancer, and diabetes. The objective of this study was to estimate the level of participation in aerobic, muscle-strengthening, and flexibility activities among Americans aged 50 years or older.MethodsUsing population-based data from the 2001 National Health Interview Survey, we classified qualified respondents (N = 11,969 according to whether they met the activity criteria used in Healthy People 2010 goals for leisure-time participation in regular aerobic physical activity, vigorous-intensity aerobic activity, strength-training activity, and flexibility activity. We also classified respondents according to their level of aerobic activity (i.e., inactive, insufficiently active, and regularly active.ResultsWe estimated that 46.4% of older Americans engaged in no leisure-time aerobic activity; that 26.1% were regularly active (participated in light- to moderate-intensity aerobic activities at least 5 days per week for at least 30 minutes or vigorous-intensity activities at least 3 days per week for at least 20 minutes; that 16.2% participated in vigorous-intensity aerobic activities at least 3 days per week for at least 20 minutes; that 13.7% participated in strength-training activities at least 2 days per week; and that 24.5% participated in flexibility activities at least 1 day per week. Among the 26.1% of older Americans who were regularly active, 30.5% engaged in strengthen-training activities at least 2 days per week. Overall, only 8.2% of older Americans met the criteria for both aerobic and strength-training activity.ConclusionAs of 2001, the percentage of older Americans who met recommended activity levels of physical activity were well below the goals for U.S. adults in Healthy People 2010. Further efforts are needed to encourage older Americans to engage in

  7. The older adult driver.

    Science.gov (United States)

    Carr, D B

    2000-01-01

    More adults aged 65 and older will be driving in the next few decades. Many older drivers are safe behind the wheel and do not need intensive testing for license renewal. Others, however, have physiologic or cognitive impairments that can affect their mobility and driving safety. When an older patient's driving competency is questioned, a comprehensive, step-by-step assessment is recommended. Many diseases that impair driving ability can be detected and treated effectively by family physicians. Physicians should take an active role in assessing and reducing the risk for injury in a motor vehicle and, when possible, prevent or delay driving cessation in their patients. Referral to other health care professionals, such as an occupational or physical therapist, may be helpful for evaluation and treatment. When an older patient is no longer permitted or able to drive, the physician should counsel the patient about using alternative methods of transportation. PMID:10643955

  8. Yoga and Older Adults

    Science.gov (United States)

    ... My Go4Life Get Free Stuff Be a Partner Yoga and Older Adults Yoga is a mind and body practice that typically ... breathing exercises, and relaxation. Researchers are studying how yoga may help improve health and to learn more ...

  9. Food patterns of Polish older people

    DEFF Research Database (Denmark)

    Wadolowska, L.; Danowska-Oziewicz, M.; Niedzwiedzka, E.;

    2006-01-01

    Food patterns of Polish older people were separated and described. The research included 422 people aged 65+ years, living in 5 geographical locations. Participants of the study were selected in quota sampling. Criteria for recruitment included sex, age (65-^74 or 75+ years) and family status...

  10. Depression in Older Adults

    OpenAIRE

    Fiske, Amy; Wetherell, Julie Loebach; Gatz, Margaret

    2009-01-01

    Depression is less prevalent among older adults than among younger adults but can have serious consequences. Over half of cases represent a first onset in later life. Although suicide rates in the elderly are declining, they are still higher than in younger adults and more closely associated with depression. Depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. Risk fac...

  11. PTSD in older bereaved people.

    Science.gov (United States)

    O'Connor, Maja

    2010-08-01

    Late life bereavement has been associated with psychological problems, mainly depression. A few studies indicated that posttraumatic stress disorder (PTSD) was an important issue in late life bereavement reactions. This study aimed to assess the prevalence of PTSD in recently bereaved older people compared with married controls and to investigate whether the loss of a spouse in old age, in contrast with earlier assumptions, could lead to PTSD. Two hundred and ninety-six Danish older bereaved people (mean age 73 years, 113 males) were chosen from national registers and assessed two months postbereavement. They were compared with a control group of 276 married older people. The prevalence of PTSD and depression were measured through a self-report questionnaire. Results showed that 16% of the bereaved and 4% of the control group had a PTSD diagnosis (ES = 0.35; Cohen's d = 0.74). Additionally, 37% of the bereaved and 22% of the control group had mild to severe depression (ES = 0.19; Cohen's d = 0.37). The results suggested that late life spousal bereavement result in PTSD with equal frequency to general samples of bereaved persons. Furthermore, the prevalence of PTSD in the first months after bereavement was more elevated than the level of depression. This makes PTSD an important factor when studying late life bereavement reactions. PMID:20686978

  12. A 17-billion-solar-mass black hole in a group galaxy with a diffuse core

    Science.gov (United States)

    Thomas, Jens; Ma, Chung-Pei; McConnell, Nicholas J.; Greene, Jenny E.; Blakeslee, John P.; Janish, Ryan

    2016-04-01

    Quasars are associated with and powered by the accretion of material onto massive black holes; the detection of highly luminous quasars with redshifts greater than z = 6 suggests that black holes of up to ten billion solar masses already existed 13 billion years ago. Two possible present-day ‘dormant’ descendants of this population of ‘active’ black holes have been found in the galaxies NGC 3842 and NGC 4889 at the centres of the Leo and Coma galaxy clusters, which together form the central region of the Great Wall—the largest local structure of galaxies. The most luminous quasars, however, are not confined to such high-density regions of the early Universe; yet dormant black holes of this high mass have not yet been found outside of modern-day rich clusters. Here we report observations of the stellar velocity distribution in the galaxy NGC 1600—a relatively isolated elliptical galaxy near the centre of a galaxy group at a distance of 64 megaparsecs from Earth. We use orbit superposition models to determine that the black hole at the centre of NGC 1600 has a mass of 17 billion solar masses. The spatial distribution of stars near the centre of NGC 1600 is rather diffuse. We find that the region of depleted stellar density in the cores of massive elliptical galaxies extends over the same radius as the gravitational sphere of influence of the central black holes, and interpret this as the dynamical imprint of the black holes.

  13. Survivability demonstration and characterization of a multi-billion shot, Q-switched, Nd:YAG laser

    Energy Technology Data Exchange (ETDEWEB)

    Dallas, J.L.; Stephen, M.A.; Afzal, R.S. [NASA, Greenbelt, MD (United States)

    1996-12-31

    As part of NASA`s suite of Earth Observing Satellites, Goddard Space Flight Center is developing a laser altimeter for measuring the polar ice sheet mass balance. The Geoscience Laser Altimeter System (GLAS) requires a diode pumped, Q-switched, Nd:YAG laser transmitter producing 150 mJ, 4 ns pulses at a 40 Hz repetition rate in a single transverse mode. The mission lifetime goal is five years (6.3 billion shots). The projected performance of the GLAS laser can be limited by a number of failure sources including optical damage to the components and degradation of the pump laser diodes. To the authors` knowledge, no data exists describing the multi-billion shot accumulative exposure effect Q-switched, 4 ns pulses have on intracavity optical components. To obtain multi-billion shot results in a reasonable time, an accelerated repetition rate (500 Hz) version of the GLAS oscillator was built with modifications for thermal management. An Accelerated GLAS Exposure Station (AGES) was developed to autonomously monitor the laser`s vital signs. Upon analysis of the stored data, the system dynamics were decoupled to identify the sources of degradation. Over 7 billion shots were accumulated during AGES` non-stop 5.5 month operation.

  14. Application of therapeutic ERCP in patients 80 years of age and older%高龄患者进行治疗性逆行胆管造影的经验体会

    Institute of Scientific and Technical Information of China (English)

    邵晓冬; 郭晓钟; 任丽楠; 赵佳均; 梁振东; 林浩

    2013-01-01

    Objective To evaluate the efficacy and the safety of therapeutic ERCP in patients 80 years of age and older with biliary and pancreatic diseases. Methods Patients with biliary and pancreatic diseases treated with therapeutic ERCP in our hospital from December 2005 to December 2011 were retrospectively reviewed. Results Two hundred and thirty seven patients underwent 268 therapeutic ERCP procedures. The indications included choledocholithiasis( 53. 2% ), malignant obstructive jaundice( 20. 2% ), biliary pancreatitis ( 10. 5% ),acute suppurative cholangitis( 9. 7% ),benign biliary stricture( 3. 4% )and others( 3. 0% ). The success rate of therapeutic ERCP was 94. 9% and 14. 6% of all procedures were emergent. Bile duct stones were completely cleared in 95. 4% of patients with cho-ledocholithiasis. Four patients underwent ERBD and two patients were referred for surgical intervention due to unsuccessful clearance of bile duct stone. Metal biliary stents were inserted in 23 patients with malignant obstructive jaundice. Plastic biliary stents were inserted in 34 patients,of which 11 patients underwent stent replacement because of stent occlustion. Unsuccessful ERCP procedures occurred in 12 cases. There were 183( 77. 2% )patients with peripapillary diverticulum. Complications occurred in 6 patients including cholangitis( 2 cases ), pancreatitis( 1 case ), hemorrhage( 2 cases )and perforation( 1 case )and there was no death case in the group. Conclusion For patients 80 years of age and older with biliary and pancreatic diseases, therapeutic ERCP is an effective and safe treatment.%目的 评估在80岁以上高龄患者中经逆行胆管造影(ERCP)进行胆胰疾病治疗的疗效和安全性.方法 回顾性分析该院自2005年12月-2011年12月经ERCP进行胆胰疾病治疗的80岁以上高龄患者的病历资料.结果 237例80岁以上高龄患者共进行了268例次治疗性ERCP.患者行ERCP治疗的原因有:胆管结石(53.2%)、恶性梗阻性黄疸(20.2%)

  15. Preventing Malnutrition in Older Adults

    Science.gov (United States)

    ... 3.7 million older adults are malnourished. Good nutrition is very important for all older adults. It is especially important for older adults who ... can be hard to tell if an older adult is malnourished. Check the ... your loved one’s risk of nutrition problems, and keep an eye out for the ...

  16. Inmunogenicidad y tolerancia de una vacuna contra influenza, en una población mexicana mayor de 55 años de edad Immunogenicity and safety of the influenza vaccine, in a population older than 55-years in Mexico

    Directory of Open Access Journals (Sweden)

    Octavio Ayala-Montiel

    2005-04-01

    ños de edad. Se demostró también la producción de anticuerpos de alta afinidad contra el virus, posterior a la vacunación. Además, se identificó una frecuencia de reacciones locales y sistémicas similares a las previamente reportadas. Estos resultados pueden ser extensivos a instituciones de salud que atienden principalmente a adultos mayores de 55 años de edad, para incrementar las tasas anuales de cobertura de vacunación contra influenza.OBJECTIVE: To confirm the immunogenicity and tolerance of the inactivated, fractionated, and purified influenza vaccine, in a Mexican adult population aged 55 and older, medically served at a Petróleos Mexicanos Hospital (Pemex, Mexican Oil Company. MATERIAL AND METHODS: The study was conducted between November and December, 2000, among ninety adult subjects aged 55 years and older who were seen at the Hospital Central Sur Pemex. The primary endpoints regarding immunogenicity were the percentage of individuals with protective antibodies targeting hemagglutinins higher than or equal to 1:40, and the percentage of subjects who seroconverted as measured by a four-fold increase in protective antibody production. Secondary endpoints included the frequency of local and systemic reactions to the vaccine. An additional criterion that was evaluated included antigen-antibody affinity assays to measure the polyclonal antibody response to the vaccine and the specific generation of high-affinity antibodies to viral proteins, before and after vaccination. RESULTS: The antibody protection rate was 95.6% against the H1N1 strain, 98.9% against the H3N2 strain, and a 100% against the B/Yamanashi strain. Seroconversion to the H1N1 strain was elicited in 74.4% of subjects, to the H3N2 strain in 88.9%, and to the B / Yamanashi strain in 82.2%. Eighteen (20% subjects developed local reactions; 17 (18.8% developed a systemic reaction post vaccination at day 5 and nine subjects (10% at day 28. Local reactions consisted of pain in 10 (11.1% subjects

  17. Older African American Women’s Lived Experiences with Depression

    OpenAIRE

    Ward, Earlise C.; Mengesha, Maigenete; Issa, Fathiya

    2013-01-01

    Little is known about older African American women’s lived experiences with depression. What does depression mean to this group? What are they doing about their depression? Unfortunately, these questions are unanswered. This study examined older African American women’s lived experiences with depression and coping behaviours. The common sense model provided the theoretical framework for present study. Thirteen community-dwelling African American women aged 60 and older (M =71 years) participa...

  18. Older adults and sport and physical activity professionals in Spain

    OpenAIRE

    María Martín-Rodríguez; María Dolores González-Rivera; José Emilio Jiménez-Beatty; Antonio Campos-Izquierdo; David del Hierro-Pinés

    2010-01-01

    Presence of monitors in physical activities and sports practiced by adults older than 64 years of age in Spain is analyzed in this research. The objective of this study is to determine the existence of monitors in relation to the sociodemographic features of older adults, the size of municipalities, the activities practiced, and the organizations where they are performed. The methodology used included a cross-sectional survey applied to a sample of older adults in Spain. The most relevant ...

  19. SAME-SEX PARTNERSHIPS AND THE HEALTH OF OLDER ADULTS

    OpenAIRE

    Williams, Mark Edward; Fredriksen-Goldsen, Karen I.

    2014-01-01

    While extensive research has examined associations between marriage, cohabitation, and the health of heterosexual adults, it remains unclear whether similar patterns of health are associated with same-sex partnerships for lesbian, gay, and bisexual (LGB) older adults. This article examines whether having a same-sex partner is associated with general self-reported health and depressive symptoms for LGB older adults. Based on survey data collected from LGB adults 50 years of age and older, havi...

  20. A 17-billion-solar-mass black hole in a group galaxy with a diffuse core

    CERN Document Server

    Thomas, Jens; McConnell, Nicholas J; Greene, Jenny E; Blakeslee, John P; Janish, Ryan

    2016-01-01

    Quasars are associated with and powered by the accretion of material onto massive black holes; the detection of highly luminous quasars with redshifts greater than z = 6 suggests that black holes of up to ten billion solar masses already existed 13 billion years ago. Two possible present-day dormant descendants of this population of active black holes have been found in the galaxies NGC 3842 and NGC 4889 at the centres of the Leo and Coma galaxy clusters, which together form the central region of the Great Wall - the largest local structure of galaxies. The most luminous quasars, however, are not confined to such high-density regions of the early Universe; yet dormant black holes of this high mass have not yet been found outside of modern-day rich clusters. Here we report observations of the stellar velocity distribution in the galaxy NGC 1600 - a relatively isolated elliptical galaxy near the centre of a galaxy group at a distance of 64 Mpc from Earth. We use orbit superposition models to determine that the ...

  1. Assessing the Prayer Lives of Older Whites, Older Blacks and Older Mexican Americans: A Descriptive Analysis

    OpenAIRE

    Krause, Neal

    2011-01-01

    The purpose of this study was to see whether differences emerge between older whites, older blacks, and older Mexican Americans in 12 measures of prayer. These measures assess four dimensions of prayer: The social context of prayer, interpersonal aspects of prayer, beliefs about how prayer operates, and the content or focus of prayers. Data from two nationwide surveys of older adults suggest that with respect to all four dimensions, the prayer lives of older whites appear be less developed th...

  2. Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen

    OpenAIRE

    Maury, Sébastien; Bacigalupo, Andrea; Anderlini, Paolo; Aljurf, Mahmoud; Marsh, Judith; Socié, Gérard; Oneto, Rosi; Passweg, Jakob R

    2009-01-01

    Upfront or second line allogeneic hematopoietic stem cell transplantation (HSCT) offers a good disease-free survival option for patients suffering from severe idiopathic aplastic anemia. This report shows improved outcome of reduced-intensity versus conventional conditioning in HLA-identical sibling HSCT for older aplastic anemia patients.

  3. Company Policies on Working Hours and Night Work in Relation to Older Workers’ Work Ability and Work Engagement: Results From a Dutch Longitudinal Study with 2 Year Follow-Up

    NARCIS (Netherlands)

    Meer, L. van der; Leijten, F.R.; Heuvel, S.G. van den; Ybema, J.F.; Wind, A. de; Burdorf, A.; Geuskens, G.A.

    2015-01-01

    Purpose To longitudinally investigate (1) whether lower work ability and work engagement predict the use of company policies on reduced working hours and exemption from evening/night work among older workers, and (2) whether using such policies subsequently contribute to higher work ability and work

  4. Relationship between Stage of Chronic Kidney Disease and Sarcopenia in Korean Aged 40 Years and Older Using the Korea National Health and Nutrition Examination Surveys (KNHANES IV-2, 3, and V-1, 2, 2008-2011.

    Directory of Open Access Journals (Sweden)

    Sung Jin Moon

    Full Text Available Protein-energy wasting is common in patients with end-stage kidney disease. However, few studies have examined the relationship between early stages of chronic kidney disease (CKD and sarcopenia.We conducted a cross-sectional study based on data in the Korea National Health and Nutrition Examination Survey, 2008-2011. In total, 11,625 subjects aged 40 years or older who underwent dual-energy X-ray absorptiometry were analyzed. Sarcopenia was defined based on values of appendicular skeletal muscle mass as a percentage of body weight (ASM/Wt two standard deviations below the gender-specific mean for young adults. Estimated glomerular filtration rates (eGFR were calculated using the CKD-EPI equation.Mean age, body mass index (BMI, and HOMA-IR were higher and caloric intake, physical activity, and vitamin D level were lower in the sarcopenia groups in both men and women. As the stage of CKD increased, the prevalence of sarcopenia increased, even in the early stages of CKD (normal and CKD1, 2, and 3-5: 2.6%, 5.6%, and 18.1% in men and 5.3%, 7.1%, and 12.6% in women, respectively; p < 0.001. In addition, a correlation analysis showed that GFR and ASM/Wt had significant correlations in both men and women. Logistic regression analyses, after adjusting for age, BMI, caloric intake, log(physical activity, vitamin D level, and log(HOMA-IR, showed that the odds ratio for sarcopenia with respect to CKD 3-5 was 1.93 (95% CI = 1.02-3.68 in men but was not statistically significant in women.The prevalence of sarcopenia was higher in elderly Korean patients with even mildly reduced kidney function. Stage of CKD was associated with an increased prevalence of sarcopenia in men but not women. Thus, we should evaluate the risk of sarcopenia and work to prevent it, even in patients with early CKD.

  5. Habits of use of videogames in Spain between older than 35 years / Hábitos de uso de los videojuegos en España entre los mayores de 35 años

    Directory of Open Access Journals (Sweden)

    Joaquín Pérez Martín

    2009-01-01

    Full Text Available Videogames are showing a growing degree of social implantation, mainly in more developed countries. This circumstance is demonstrated because their influence is extended not only to younger groups but to all the society too. Altogether with innovations like television, internet o mobile telephony, videogames are contributing to change the traditional pattern of accessing and transmission of knowledge, that passes from reading written texts to viewing audiovisual and multimedia contents. This article, based in a research referred to more than 900 people, analyzes which is the degree of its penetration in Spain between older than 35 years and which are the habits of use of this technology between this group. In order to do this, the article exams items like habits of playing by ages, daily dedication, range of playing during day and week and aspects more valued in videogames.Los videojuegos demuestran un creciente grado de implantación social, particularmente perceptible en los países más desarrollados. Tal circunstancia se manifiesta porque su influencia ya no se limita exclusivamente a los grupos poblacionales más jóvenes sino que actualmente alcanzan la totalidad de la sociedad. Conjuntamente con innovaciones como la televisión, internet o la telefonía móvil, los videojuegos están contribuyendo a modificar el tradicional proceso de acceso y transmisión del conocimiento, que pasa de basarse en la lectura del texto escrito a la contemplación de contenidos audiovisuales y multimedia. Este artículo, que se basa en una investigación planteada a más de 900 individuos, analiza cuál es su grado de implantación en España entre las personas mayores de 35 años y cuáles son los hábitos de uso de esta tecnología entre dicho grupo poblacional. Para ello examina variables como hábitos de juego por edades, dedicación diaria, franjas del día y de la semana más habituales y aspectos más valorados en los videojuegos.

  6. Pedestrian fatalities and injuries involving Irish older people.

    LENUS (Irish Health Repository)

    Martin, A J

    2012-02-01

    BACKGROUND: It has been established internationally that road traffic accidents (RTAs) involving older drivers follow clearly different patterns of timing, location and outcomes from those of younger age groups. Older pedestrians are also a vulnerable group and fewer analyses have been undertaken of the phenomenology of their injuries and fatalities. We studied the pattern of pedestrian RTAs in Ireland over a five-year period with the aim of identifying differences between older pedestrians (aged 65 or older) and younger adults. METHODS: We examined the datasets of the Irish National Road Authority (now the Road Safety Authority) from 1998-2002. We analysed patterns of crashes involving older pedestrians (aged 65) and compared them with younger adults (aged 18-64). RESULTS: Older people represented 36% (n = 134) of pedestrian fatalities and 23% of serious injuries while they only account for 19% of total RTAs. Mortality in RTA is more than doubled for older pedestrians compared to younger adults (RR 2.30). Most accidents involving older pedestrians happen in daylight with good visibility (56%) and in good weather conditions (77%). CONCLUSIONS: Older pedestrians are particularly vulnerable in RTAs. These occur more frequently during daylight hours and in good weather conditions. This may point to a need for prevention strategies that are targeted at the traffic environment and other road users rather than at older people.

  7. The older woman: beyond the stereotype.

    Science.gov (United States)

    1995-01-01

    During 1975-2025 the population aged over 60 years is expected to increase by 225%, of whom almost 50% will be "old old" or aged over 70 years. Females are expected be the dominant gender among the aged. Over 70% of the aged in 2025 are expected to live in developing countries. Elderly women are faced with health care cost and psychological changes from isolation or institutional impacts from job loss or lack of appropriate skills for the job market. Women tend to remain active in the informal sector. Public discussion of the issues of the elderly is more likely in industrialized countries. Few studies focus on differences in the aging experience of women compared to men. The issues of aging are viewed in this article as a development issue and a women's issue. The UN Mexico City Conference was the first time that the older woman as an issue, even though a small one, was on the international agenda. The second women's conference in Copenhagen called for an emphasis on older women. The 1982 Vienna Plan of Action made one recommendation out of 62 on the inequities of older women. The 1985 women's conference in Nairobi established that aging was a developmental stage in the life cycle. Since 1985, older women have received inclusion in all development strategies and programs and recognition by numerous UN groups. 1999 will be commemorated as the International Year of Older Persons. At that time a review will be complete of the International Plan of Action on Aging. INSTRAW and the UN Commission of Social Development recently released their report on the conditions of older women based on baseline data on age and sex. Some of the findings are summarized in this article. Trends reflect that the elderly are living alone in developed countries and in extended families in developing countries. Culture is a factor affecting living arrangements. Marital ties are the key factor for women's social and economic well-being. Men are more likely to remarry at older ages. Family

  8. INTERVENTIONS FOR INCREASING BALANCE & CONFIDENCE IN OLDER ADULTS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Foram Dhebar

    2014-08-01

    Full Text Available Elderly is defined as being 65 years of age or older. Geriatrics or geriatric medicine is a specialty that focuses on health care of elderly people. The number of persons above the age of 60 years is fast growing, especially in India. Falls are the leading cause of traumatic brain injury, fractures & the leading cause of emergency department visits by older adults. Low balance confidence is a major health problem among older adults restricting their participation in daily life. Objective of this review is to determine what interventions are most effective in increasing balance confidence in older adults. The American Geriatrics Society (AGS published clinical guidelines 2011 that recommended all adults aged 65 years and older be screened for falls. Prevention of the fall can be done by combination of exercise include Strengthening exercise, Balance & co-ordination exercise,Hydrotherapy and allied therapeutics such as tai chi and yoga.

  9. Prevalência de dilatação da aorta abdominal em coronariopatas idosos Prevalence of abdominal aortic dilatation in patients aged 60 years or older with coronary disease

    Directory of Open Access Journals (Sweden)

    Guilherme Vieira Meirelles

    2007-06-01

    Full Text Available CONTEXTO: A realização de programas de triagem para o aneurisma da aorta abdominal de forma indiscriminada auxiliará uma pequena porcentagem de indivíduos, mas ao considerarmos grupos com fatores de risco relacionados à dilatação da aorta, aumentando a probabilidade da doença, este permitirá um direcionamento adequado dos recursos e um benefício maior à população. Programas direcionados pelas sociedades médicas, permitindo um diagnóstico precoce das doenças vasculares e conseqüentemente um melhor preparo do doente, promoveriam melhores taxas de sobrevida com menor morbidade. OBJETIVO: Avaliar a prevalência da dilatação da aorta abdominal em uma amostra de pacientes idosos com mais de 60 anos de idade, portadores de coronariopatia aterosclerótica diagnosticada por cineangiocoronariografia. MÉTODOS: Para a seleção dessa amostra, levou-se em consideração o fato de que a avaliação pré-operatória de cirurgia vascular não tenhasido a indicação do cateterismo. Procedeu-se então a avaliação, baseada na anamnese, exame físico e Doppler ultra-som da aorta abdominal. A análise estatística iniciou-se com o teste qui-quadrado, com a posterior análise de regressão logística multivariada e regressão logística univariada, considerando significativo um p BACKGROUND: Indiscriminate screening programs for abdominal aortic aneurysm will help a small percentage of individuals. However, when considering groups with risk factors associated with aortic dilatation, which increases the probability of the disease, such programs will provide an adequate allocation of resources and a greater benefit to the population. Programs guided by medical societies, providing an early diagnosis of vascular diseases and consequently a better preparation of patients, would result in better survival rates with lower morbidity. OBJECTIVE: To evaluate the prevalence of abdominal aortic dilatation in patients aged 60 years or older with

  10. Smoking and Older Adults

    Centers for Disease Control (CDC) Podcasts

    2008-10-27

    This podcast discusses the importance of older adults quitting smoking and other tobacco products. It is primarily targeted to public health and aging services professionals.  Created: 10/27/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 11/20/2008.

  11. Rehabilitation and older people.

    OpenAIRE

    Young, J.

    1996-01-01

    Rehabilitation is concerned with lessening the impact of disabling conditions. These are particularly common in older people and considerable health gain can be achieved by successful rehabilitation. Hospital doctors and general practitioners should be aware of the core principles of rehabilitation, be able to recognise rehabilitation need in their patients, and have sufficient knowledge of their local rehabilitation services to trigger the referral process.

  12. Older Women and Poverty.

    Science.gov (United States)

    Ferraro, Geraldine A.

    1982-01-01

    Discusses the socioeconomic causes of the disproportionate level of poverty found among women aged 65 and over. Reasons why Social Security programs are essential for maintaining minimal standards of living for many older women are presented. Specific proposals for bringing about change are included. (AM)

  13. Dance for Older Adults.

    Science.gov (United States)

    Pruett, Diane Milhan, Ed.; And Others

    1983-01-01

    Dance programs for older adults that encourage exercise and socializing are described in six articles. Program guidelines of the American Alliance Committee on Aging are explained, and other articles emphasize a movement education approach that may involve intergenerational contact. A dance program held in a worship setting is also discussed. (PP)

  14. Emotional Wellness Needs: Older Adults in Rural Communities

    Science.gov (United States)

    Russ, Randall

    2009-01-01

    The importance of emotional wellness for rural older adults is a topic of growing significance. Older adults, now the fastest growing United States population sector, have special wellness needs. By the year 2030, about 70 million people will be over the age of 65. A low or declining sense of control over one's life increases depression. Emotional…

  15. Evaluation of a Spiritually Focused Intervention with Older Trauma Survivors

    Science.gov (United States)

    Bowland, Sharon; Edmond, Tonya; Fallot, Roger D.

    2012-01-01

    This study evaluated the effectiveness of an 11-session, spiritually focused group intervention with older women survivors (age 55 years and older) of interpersonal trauma (child abuse, sexual assault, or domestic violence) in reducing trauma-related depressive symptoms, posttraumatic stress, and anxiety. Forty-three community-dwelling women…

  16. Assessment of Anxiety in Older Home Care Recipients

    Science.gov (United States)

    Diefenbach, Gretchen J.; Tolin, David F.; Meunier, Suzanne A.; Gilliam, Christina M.

    2009-01-01

    Purpose: This study determined the psychometric properties of a variety of anxiety measures administered to older adults receiving home care services. Design and Methods: Data were collected from 66 adults aged 65 years and older who were receiving home care services. Participants completed self-report and clinician-rated measures of anxiety and…

  17. ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN OLDER ADULTS WITH DIABETES MELLITUS

    OpenAIRE

    Barzilay, Joshua I.; Mukamal, Kenneth J.; Kizer, Jorge R.

    2014-01-01

    Diabetes Mellitus exerts a strong effect on atherosclerotic cardiovascular disease risk into older age (beyond ages 70 to 74 years). This effect is particularly noticeable with regard to coronary artery disease and cerebral microvascular disease. Thus Diabetes Mellitus in older age deserves the same careful medical attention as it does in middle age.

  18. Why Social Exclusion Persists among Older People in Australia

    Directory of Open Access Journals (Sweden)

    Riyana Miranti

    2015-07-01

    Full Text Available The existing literature on social exclusion among older people, though relatively limited, suggests that disadvantage among older people is cumulative in nature. Some aspects of disadvantage starting at early life stages have long-term consequences. As such, older people with disadvantages may be subject to higher risks of persistent social exclusion. This article aims to improve understanding of social exclusion and its persistence among senior Australians in three ways. Firstly, the incidence of social exclusion among older people is analysed using selected indicators. Secondly, the study examines whether an older person experiencing social exclusion at one time is more likely to experience it again (persistence. Thirdly, it investigates what factors may be protecting older people from social exclusion. The analysis is conducted using the first eight waves of the Household, Income and Labour Dynamics in Australia (HILDA Survey. The sample of older people is disaggregated into a younger group (55–64 years at wave 1 and an older group (65+ years. The article suggests that higher education and income, as well as better health conditions and previous employment experiences, are important protective factors from social exclusion for older Australians.

  19. Older Workers and VET. At a Glance

    Science.gov (United States)

    Dawe, Susan

    2009-01-01

    Australia, in common with many industrialised countries, must adjust in the coming years to an ageing population. The labour force participation rate is projected to fall and there will be a record number of older people who have retired from work. Thus, there will be fewer workers as a share of the population to generate the income needed to…

  20. PetroChina to Invest US$60 Billion for Worldwide Expansion

    Institute of Scientific and Technical Information of China (English)

    Liu Geng

    2010-01-01

    @@ PetroChina plans to spend at least US$60 billion in the next decade on overseas acquisitions,challenging ExxonMobil and BP in the race to control oil and gas fields."Ten years ago,PetroChina was a State-owned oil company,but now we aim at becoming an international,integrated energy company,"Jiang Jiemin,chairman of the world's largest company by market value,said in an interview with news media in late March,in which he announced the investment plan.This move aims to secure the company's annual output of oil and natural gas in foreign lands equivalent to 200 million tons of oil.

  1. Zooming the Zoomers : The portrayal of older consumers in printed adverts and the perceptions of this portrayal of younger and older consumers

    OpenAIRE

    Holkko Lafourcade, Johanna; Josefsson, Lisa

    2010-01-01

    Purpose: The purpose of this thesis is two folded: firstly to do a content analysis on how consumers older than 55 years (Zoomers) are portrayed in advertisements in the largest Swedish magazines, and secondly, to uncover what perceptions of this portrayal that older and younger consumers have. Background: The population of the world is growing older, and thus older consumers (+55) are a large and rapidly growing group of the population which also are strong in purchasing power. Research ind...

  2. Deliveries of district heat amounted 5.1 billion FIM in 1999

    International Nuclear Information System (INIS)

    The sales of district heat in 1999 was 26.2 TWh, which is about 5% less than in 1998. The decrease was due to milder weather conditions. The year 1999 was more than 1 deg C warmer than the long-term average. The value of the sales was 5.1 billion FIM. The share of residences of the district heat sales was 52%, corresponding to 2.7 billion FIM. The number of district heated residences at the end of 1999 was 1 080 000. Nearly a half of the buildings in Finland were connected to district heating. In largest cities the share is nearly 90%. In total 28 TWh of district heat was generated in 1999, which is nearly 5% less than in 1998. About 77% of the district heat was generated at combined heat and power plants. About 12.2 TWh of electric power was generated at combined heat and power plants. The share of electric power generated at combined heat and power plants decreased by 4% from the year 1998. About 36% of district heat and co-generation power were generated with natural gas. The share of coal was 26%, which is 3.5% less than in 1998. The shares of indigenous fuels remained on the same level as in 1998. A fifth of the fuels was peat. The share of peat decreased by 1%. The share of other indigenous fuels (wood, biogas, and industrial waste heat) was 8%, being the same as the share of oil. The average price of district heat was 19.5 p/kWh, which is about 1% higher than in 1998. The share of taxes of the price of district heat is 30%. The article is based on the preliminary information on generation and delivery of district heat in 1999. The press release is available in URL http://www.energia.fi/sky/eindex.htm

  3. Hip Fractures among Older Adults

    Science.gov (United States)

    ... online training for health care providers. Learn More Hip Fractures Among Older Adults Recommend on Facebook Tweet ... get older. What You Can Do to Prevent Hip Fractures You can prevent hip fractures by taking ...

  4. Dementia: Unique to Older Adults

    Science.gov (United States)

    ... our e-newsletter! Aging & Health A to Z Dementia Unique to Older Adults This section provides information ... Managing Additional Health Problems in Older Adults with Dementia Dementia is rare in adults younger than 60. ...

  5. Diabetes Resources for Older Adults

    Science.gov (United States)

    ... Follow Us Health Information > Health Communication Programs > National Diabetes Education Program > Living With Diabetes > Diabetes in Older Adults | ... it's more common in older adults. The National Diabetes Education Program offers access to a range of resources ...

  6. 40岁以上成年骨肉瘤患者的外科治疗及预后因素%Surgical treatment and prognostic analysis of osteosarcoma in adults older than 40 years

    Institute of Scientific and Technical Information of China (English)

    唐顺; 郭卫; 杨荣利; 汤小东; 李大森; 董森

    2015-01-01

    Objective: To determine the prognostic factors of primary osteosarcoma in adults . Methods:This is a review of 54 patients older than 40 years (24 men and 30 women) who were treated between 1998 and 2011 at the authors ’ institution .Demographic information and follow-up data were obtained and statistically analyzed .Results: Tumors involved the limbs in 30 patients ( 55 .5%) and axial skeleton in 17 patients (31.5%), and arose from soft tissue in 7 patients (13%).And 6 patients (11.1%) had synchronous metastasis .According to our review , tumors were treated surgically in 52 patients (96.3%).Local recurrence was documented in 14 patients (26.9%).Metastasis after diagno-sis appeared in 21 patients (38.9%).In the 52 patients who received the surgical treatment , the 5 year disease-free survival and overall survival rates were 43.7% and 50.4%, respectively.Conclusion:Adult patients with primary osteosarcoma had a poor clinical outcome .Inadequate surgical margins , more tumors in the axial location due to high recurrence rates , metastatic disease at presentation , and large tumor volumes were associated with significantly lower survival rates .Aggressive multi-agent treatment regimens might improve survival .%目的:确定原发成人骨肉瘤患者的相关预后因素。方法:对1998年10月到2011年10月在北京大学人民医院骨肿瘤中心接收治疗的54例年龄超过40岁的成年骨肉瘤患者(其中男性24例,女性30例)的临床资料进行回顾性分析。结果:肿瘤位于肢体骨30例(55.5%)、中轴骨17例(31.5%)、骨外软组织7例(13%),6例患者(11.1%)在诊断时伴有其他部位转移,52例患者(96.3%)接受了手术治疗,14例患者局部复发(26.9%),21例患者(38.9%)诊断后出现转移。52例接受手术治疗的骨肉瘤患者5年的无病生存率和总体生存率分别为43.7%和50.4%。结论:造成成人骨肉瘤患者预后较

  7. Yichuan Power’s High-precision Aluminum Belt Project Invests RMB2.95 Billion

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>Yichuan Power Group’s continuous casting and rolling aluminum belt project features an annual production capacity of 250,000 tons and commenced construction in April 2009.Total investment in the project will be RMB2.95 billion, and following production,sales income are projected to reach RMB5.2 billion,with profits and taxes amounting to RMB0.6 billion.

  8. Connecting galaxy and supermassive black hole growth during the last 8 billion years

    Science.gov (United States)

    Juneau, Stephanie

    It has become increasingly clear that a complete picture of galaxy evolution requires a better understanding of the role of Active Galactic Nuclei (AGN). In particular, they could be responsible for regulating star formation and galaxy growth via feedback processes. There are also competing views about the main modes of stellar growth and supermassive black hole growth in galaxies that need to be resolved. With high infrared luminosities (thus star formation rates) and a frequent occurrence of AGN, galaxies selected in the far-infrared wavebands form an ideal sample to search for a connection between AGN and star formation. The first part of this thesis contains a detailed analysis of the molecular gas properties of nearby infrared luminous and ultraluminous infrared galaxies (LIRGs and ULIRGs). We find that the enhanced molecular gas density in the most IR-luminous systems can be explained by major galaxy mergers, and that AGN are more likely to reside in higher-density systems. While the frequent concurrence of AGN and galaxy mergers in ULIRGs was already established, this work provides a coherent framework that explains trends observed with five molecular gas tracers with a broad range of critical densities, and a comparison with simulations that reproduce observed molecular line ratios without invoking AGN-induced chemistry. The second part of the thesis presents an analysis of the AGN content of intermediate redshift galaxies (0.3 < z < 1). However, identifying complete AGN samples at these redshift is challenging because it is difficult to find X-ray weak or absorbed AGN. To alleviate this problem, we developed the Mass-Excitation (MEx) diagram, which is applicable out to redshift of ˜ 1 with existing optical spectra. It improves the overall AGN census by detecting AGN that are missed in even the most sensitive X-ray surveys. The new diagnostic was used to study the concurrence of star formation and AGN in 70 micron-selected galaxies from the Far-Infrared Deep Extragalactic Legacy survey. When multiple AGN diagnostics are combined, we find not only a high AGN fraction in FIR-selected galaxies (as high as for nearby FIR-selected galaxies), but a high incidence of X-ray absorbed AGN. These findings may have considerable implications for current views about the main mode of AGN growth.

  9. The evolution of the earth's background radiation field over the past four billion years

    International Nuclear Information System (INIS)

    It seems likely that life has evolved under an evolving background radiation field. The radiation dose from the earth itself has changed over geologic time as the crust of the earth has become enriched in radioactive elements and as those elements subsequently decayed away. The radiation dose from biologic potassium has steadily decreased with time according to the law of radioactive decay. Because of these two effects, it seems likely that early life was exposed to nearly ten times current radiation dose rates. In addition to these sources, cosmic and cosmogenic sources may have periodically raised radiation dose rates to very high levels at times in the past. These sources of radiation exposure are not well understood at present, but are the subject of ongoing research. Modern organisms may be more resistant to the adverse effects of radiation because mutation repair mechanisms evolved under higher radiation levels. This may help to shed some light on the current controversy regarding the biological effects of exposure to low levels of ionizing radiation, or it may simply help us to understand why cancer is primarily a disease of the elderly rather than the middle-aged. In addition, changing radiation levels over geologic time may help to reconcile molecular models of evolution with what is currently known from the fossil record. It may also be that this reconciliation can be used to validate the radiation dose rate models described above. Only time and further research will tell

  10. The evolution of the earth's background radiation field over the past four billion years

    International Nuclear Information System (INIS)

    Modern organisms may be more resistant to the adverse effects of radiation because mutation repair mechanisms evolved under higher radiation levels. This may help to shed some light on the current controversy regarding the biological effects of exposure to low levels of ionizing radiation. (author)

  11. Three billion years of crustal evolution in eastern Canada: Constraints from receiver functions

    Science.gov (United States)

    Petrescu, L.; Bastow, I. D.; Darbyshire, F. A.; Gilligan, A.; Bodin, T.; Menke, W.; Levin, V.

    2016-02-01

    The geological record of SE Canada spans more than 2.5 Ga, making it a natural laboratory for the study of crustal formation and evolution over time. We estimate the crustal thickness, Poisson's ratio, a proxy for bulk crustal composition, and shear velocity (Vs) structure from receiver functions at a network of seismograph stations recently deployed across the Archean Superior Craton, the Proterozoic Grenville, and the Phanerozoic Appalachian provinces. The bulk seismic crustal properties and shear velocity structure reveal a correlation with tectonic provinces of different ages: the post-Archean crust becomes thicker, faster, more heterogeneous, and more compositionally evolved. This secular variation pattern is consistent with a growing consensus that crustal growth efficiency increased at the end of the Archean. A lack of correlation among elevation, Moho topography, and gravity anomalies within the Proterozoic belt is better explained by buoyant mantle support rather than by compositional variations driven by lower crustal metamorphic reactions. A ubiquitous ˜20 km thick high-Vs lower crustal layer is imaged beneath the Proterozoic belt. The strong discontinuity at 20 km may represent the signature of extensional collapse of an orogenic plateau, accommodated by lateral crustal flow. Wide anorthosite massifs inferred to fractionate from a mafic mantle source are abundant in Proterozoic geology and are underlain by high-Vs lower crust and a gradational Moho. Mafic underplating may have provided a source for these intrusions and could have been an important post-Archean process stimulating mafic crustal growth in a vertical sense.

  12. A Powerful Toolkit for Synthetic Biology: Over 3.8 Billion Years of Evolution

    Science.gov (United States)

    Rothschild, Lynn J.

    2010-01-01

    The combination of evolutionary with engineering principles will enhance synthetic biology. Conversely, synthetic biology has the potential to enrich evolutionary biology by explaining why some adaptive space is empty, on Earth or elsewhere. Synthetic biology, the design and construction of artificial biological systems, substitutes bio-engineering for evolution, which is seen as an obstacle. But because evolution has produced the complexity and diversity of life, it provides a proven toolkit of genetic materials and principles available to synthetic biology. Evolution operates on the population level, with the populations composed of unique individuals that are historical entities. The source of genetic novelty includes mutation, gene regulation, sex, symbiosis, and interspecies gene transfer. At a phenotypic level, variation derives from regulatory control, replication and diversification of components, compartmentalization, sexual selection and speciation, among others. Variation is limited by physical constraints such as diffusion, and chemical constraints such as reaction rates and membrane fluidity. While some of these tools of evolution are currently in use in synthetic biology, all ought to be examined for utility. A hybrid approach of synthetic biology coupled with fine-tuning through evolution is suggested

  13. Intergalactic Lyman continuum photon budget in the past 5 billion years

    CERN Document Server

    Gaikwad, Prakash; Choudhury, Tirthankar Roy; Srianand, Raghunathan

    2016-01-01

    We constrain the H I photoionization rate $(\\Gamma_{\\rm HI})$ at $z \\lesssim 0.45$ by comparing the flux probability distribution function and power spectrum of the Ly-$\\alpha$ forest data along 82 QSO sightlines obtained using Cosmic Origins Spectrograph with models generated from smoothed particle hydrodynamic simulations. We have developed a module named "Code for Ionization and Temperature Evolution (CITE)" for calculating the intergalactic medium (IGM) temperature evolution from high to low redshifts by post-processing the GADGET-2 simulation outputs. Our method, that produces results consistent with other simulations, is computationally less expensive thus allowing us to explore a large parameter space. It also allows rigorous estimation of the error covariance matrix for various statistical quantities of interest. We find that the best-fit $\\Gamma_{\\rm HI}(z)$ increases with $z$ and follows $(4 \\pm 0.1) \\times 10^{-14}\\:(1+z)^{4.99 \\pm 0.12}$ s$^{-1}$. At any given $z$ the typical uncertainties $\\Delta...

  14. Evidence for oxygenic photosynthesis half a billion years before the Great Oxidation Event

    OpenAIRE

    Planavsky, Noah J.; Asael, Dan; Hofman, Axel; Reinhard, Christopher T.; Lalonde, Stefan V.; Knudsen, Andrew; WANG, Xiangli; Ossa, Frantz Ossa; Pecoits, Ernest; Smith, Albertus J. B.; Beukes, Nicolas J.; Bekker, Andrey; Johnson, Thomas M.; Konhauser, Kurt O.; Lyons, Timothy W.

    2014-01-01

    The early Earth was characterized by the absence of oxygen in the ocean–atmosphere system, in contrast to the well-oxygenated conditions that prevail today. Atmospheric concentrations first rose to appreciable levels during the Great Oxidation Event, roughly 2.5–2.3 Gyr ago. The evolution of oxygenic photosynthesis is generally accepted to have been the ultimate cause of this rise, but it has proved difficult to constrain the timing of this evolutionary innovation. The oxidation of manganese ...

  15. Rapid oxygenation of Earths atmosphere 2.33 billion years ago

    OpenAIRE

    Luo, Genming; Ono, Shuhei; Beukes, Nicolas J.; Wang, David T.; Xie, Shucheng; Summons, Roger E.

    2016-01-01

    Molecular oxygen (O[subscript 2]) is, and has been, a primary driver of biological evolution and shapes the contemporary landscape of Earth’s biogeochemical cycles. Although “whiffs” of oxygen have been documented in the Archean atmosphere, substantial O2 did not accumulate irreversibly until the Early Paleoproterozoic, during what has been termed the Great Oxygenation Event (GOE). The timing of the GOE and the rate at which this oxygenation took place have been poorly constrained until now. ...

  16. The discovery of fullerenes in the 1.85 billion-year-old Sudbury meteorite crater

    Energy Technology Data Exchange (ETDEWEB)

    Becker, L.; Bada, J.L. [Scripps Institution of Oceanography, La Jolla, CA (United States); Winans, R.E.; Hunt, J.E. [Argonne National Lab., IL (United States); Bunch, T.E. [National Aeronautics and Space Administration, Moffett Field, CA (United States). Ames Research Center; French, B.M. [National Aeronautics and Space Administration, Washington, DC (United States)

    1996-02-01

    Fullerenes (C{sub 60}, C{sub 70}) have been identified by laser time-of-flight and electron-ionization mass spectroscopy in rock samples (black tuff in the Onaping formation) from the crater. They were likely synthesized within the impact plume from carbon contained in the meteorite. The isotopic ratios suggest {sup 13}C enrichment. They are associated with sulfur which may have protected them. This is the largest known deposit of naturally occurring fullerenes.

  17. The evolution in the stellar mass of brightest cluster galaxies over the past 10 billion years

    Science.gov (United States)

    Bellstedt, Sabine; Lidman, Chris; Muzzin, Adam; Franx, Marijn; Guatelli, Susanna; Hill, Allison R.; Hoekstra, Henk; Kurinsky, Noah; Labbe, Ivo; Marchesini, Danilo; Marsan, Z. Cemile; Safavi-Naeini, Mitra; Sifón, Cristóbal; Stefanon, Mauro; van de Sande, Jesse; van Dokkum, Pieter; Weigel, Catherine

    2016-08-01

    Using a sample of 98 galaxy clusters recently imaged in the near-infrared with the European Southern Observatory (ESO) New Technology Telescope, WIYN telescope and William Herschel Telescope, supplemented with 33 clusters from the ESO archive, we measure how the stellar mass of the most massive galaxies in the universe, namely brightest cluster galaxies (BCGs), increases with time. Most of the BCGs in this new sample lie in the redshift range 0.2 theory using mock images, is required if a more detailed comparison between the models and the data is to be made.

  18. The role of bars in AGN fueling in disk galaxies over the last seven billion years

    CERN Document Server

    Cisternas, Mauricio; Salvato, Mara; Knapen, Johan H; Civano, Francesca; Santini, Paola

    2014-01-01

    We present empirical constraints on the influence of stellar bars on the fueling of active galactic nuclei (AGN) out to z=0.84 using a sample of X-ray-selected AGN hosted in luminous face-on disk galaxies from the Chandra COSMOS survey. Using high-resolution Hubble Space Telescope imaging to identify bars, we find that the fraction of barred active galaxies displays a similar behavior as that of inactive spirals, declining with redshift from 71% at z~0.3, to 35% at z~0.8. With active galaxies being typically massive, we compare them against a mass-matched sample of inactive spirals and find that the AGN bar fraction is higher, with this enhancement being marginal at z>0.4, but becoming more pronounced at low redshift. The presence of a bar has no influence on the AGN strength, with barred and unbarred active galaxies showing equivalent X-ray luminosity distributions, though barred galaxies on average seem to show higher levels of central star formation. From our results, we conclude that the role of bars is r...

  19. The First Billion Years project - IV: Proto-galaxies reionising the Universe

    CERN Document Server

    Paardekooper, Jan-Pieter; Vecchia, Claudio Dalla

    2012-01-01

    The contribution of stars in galaxies to cosmic reionisation depends on the star formation history in the Universe, the abundance of galaxies during reionisation, the escape fraction of ionising photons and the clumping factor of the inter-galactic medium (IGM). We compute the star formation rate and clumping factor during reionisation in a cosmological volume using a high-resolution hydrodynamical simulation. We post-process the output with detailed radiative transfer simulations to compute the escape fraction of ionising photons. Together, this gives us the opportunity to assess the contribution of galaxies to reionisation self-consistently. The strong mass and redshift dependence of the escape fraction indicates that reionisation occurred between z=15 and z=10 and was mainly driven by proto-galaxies forming in dark-matter haloes with masses between 1e7 and 1e8 solar mass. More massive galaxies that are rare at these redshifts and have significantly lower escape fractions contribute less photons to the reio...

  20. Could organic matter have been preserved on Mars for 3.5 billion years?

    Science.gov (United States)

    Kanavarioti, Anastassia; Mancinelli, Rocco L.

    1990-01-01

    About 3.5 Gyr ago, when it is thought that Mars and earth had similar climates, biological evolution on earth had made considerable progress, such that life was abundant. It is therefore surmised that prior to this time period, the advent of chemical evolution and subsequent origin of life occurred on earth and may have occurred on Mars. Analysis for organic compounds in the soil buried beneath the Martian surface may yield useful information regarding the occurrence of chemical evolution and possibly biological evolution. Calculations based on the stability of amino acids lead to the conclusion that remnants of these compounds, if they existed on Mars 3.5 Gyr ago, might have been preserved buried beneath the surface oxidizing layer. For example, if phenylalanine, an amino acid of average stability, existed on Mars 3.5 Gyr ago, then 1.6 percent would remain buried today. Martian soil may exist from remnants of meteoritic and cometary bombardment, assuming that 1 percent of the organics survived impact.

  1. The First Billion Years Project: The escape fraction of ionising photons in the epoch of reionisation

    CERN Document Server

    Paardekooper, Jan-Pieter; Vecchia, Claudio Dalla

    2015-01-01

    Proto-galaxies forming in low-mass dark matter haloes are thought to provide the majority of ionising photons needed to reionise the Universe, due to their high escape fractions of ionising photons. We study how the escape fraction in high-redshift galaxies relates to the physical properties of the halo in which the galaxies form by computing escape fractions for 75801 haloes between redshifts 27 and 6 that were extracted from the FiBY project, high-resolution cosmological hydrodynamics simulations of galaxy formation. We find that the main constraint on the escape fraction is the presence of dense gas within 10 pc of the young sources that emit the majority of the ionising photons produced over the lifetime of the stellar population. This results in a strong mass dependence of the escape fraction. The lower potential well in haloes with virial mass below 10^8 solar mass results in lower column densities close to the sources that can be penetrated by the radiation from young, massive stars. In general only a ...

  2. The Formation of Submillimetre-Bright Galaxies from Gas Infall over a Billion Years

    CERN Document Server

    Narayanan, Desika; Feldmann, Robert; Robitaille, Thomas; Hopkins, Philip; Thompson, Robert; Hayward, Christopher; Ball, David; Faucher-Giguere, Claude-Andre; Keres, Dusan

    2015-01-01

    Submillimetre-luminous galaxies at high-redshift are the most luminous, heavily star-forming galaxies in the Universe, and are characterised by prodigious emission in the far-infrared at 850 microns (S850 > 5 mJy). They reside in halos ~ 10^13Msun, have low gas fractions compared to main sequence disks at a comparable redshift, trace complex environments, and are not easily observable at optical wavelengths. Their physical origin remains unclear. Simulations have been able to form galaxies with the requisite luminosities, but have otherwise been unable to simultaneously match the stellar masses, star formation rates, gas fractions and environments. Here we report a cosmological hydrodynamic galaxy formation simulation that is able to form a submillimetre galaxy which simultaneously satisfies the broad range of observed physical constraints. We find that groups of galaxies residing in massive dark matter halos have rising star formation histories that peak at collective rates ~ 500-1000 Msun/yr at z=2-3, by wh...

  3. ON THE LAST 10 BILLION YEARS OF STELLAR MASS GROWTH IN STAR-FORMING GALAXIES

    International Nuclear Information System (INIS)

    The star formation rate-stellar mass relation (SFR-M*) and its evolution (i.e., the SFR main sequence) describe the growth rate of galaxies of a given stellar mass and at a given redshift. Assuming that present-day star-forming galaxies (SFGs) were always star forming in the past, these growth rate observations can be integrated to calculate average star formation histories (SFHs). Using this Main Sequence Integration (MSI) approach, we trace present-day massive SFGs back to when they were 10%-20% of their current stellar mass. The integration is robust throughout those epochs: the SFR data underpinning our calculations are consistent with the evolution of stellar mass density in this regime. Analytic approximations to these SFHs are provided. Integration-based results reaffirm previous suggestions that current SFGs formed virtually all of their stellar mass at z 2 are not the typical progenitors of SFGs today. We also check MSI-based SFHs against those inferred from analysis of the fossil record—from spectral energy distributions (SEDs) of SFGs in the Sloan Digital Sky Survey and color-magnitude diagrams (CMDs) of resolved stars in dwarf irregular galaxies. Once stellar population age uncertainties are accounted for, the main sequence is in excellent agreement with SED-based SFHs (from VESPA). Extrapolating SFR main sequence observations to dwarf galaxies, we find differences between MSI results and SFHs from CMD analysis of Advanced Camera for Surveys Nearby Galaxy Survey Treasury and Local Group galaxies. Resolved dwarfs appear to grow much slower than main sequence trends imply, and also slower than slightly higher mass SED-analyzed galaxies. This difference may signal problems with SFH determinations, but it may also signal a shift in star formation trends at the lowest stellar masses.

  4. The Last Eight-Billion Years of Intergalactic SiIV Evolution

    CERN Document Server

    Cooksey, Kathy L; Thom, Christopher; Chen, Hsiao-Wen

    2010-01-01

    We identified 24 SiIV absorption systems with z 3 sigma. The absorber line density of the G = 1 doublets was dN_SiIV/dX = 1.4+0.4/-0.3 for log N(Si+3) > 12.9. The best-fit power law to the G = 1 frequency distribution of column densities f(N(Si+3)) had normalization k = (1.2+0.5/-0.4) x 10^{-14} cm^-2 and slope alpha = -1.6+0.3/-0.3. Using the power-law model of f(N(Si+3)), we measured the Si+3 mass density relative to the critical density: Omega(Si+3) = (3.71+2.82/-1.68) x 10^-8. From a simple linear fit to Omega(Si+3) over the age of the Universe, we estimated a slow and steady increase from z = 5.5 --> 0 with dOmega/dt_age = (0.61+/-0.13) x 10^-8 Gyr^-1. We compared our ionic ratios N(Si+3)/N(C+3) to a 2 < z < 4.5 sample and concluded, from survival analysis, that the two populations are similar, with mean N(Si+3)/N(C+3) ~ 0.16.

  5. Mental health and older women.

    OpenAIRE

    Liptzin, B

    1987-01-01

    The number of elderly women is growing in absolute numbers and in proportion to the U. S. population. Current epidemiologic research indicates that the most frequent psychiatric disorders among older women are phobias, severe cognitive impairment, dysthymia, and major depressive episode without grief. The rates of all of these disorders, except for cognitive impairment, are lower for older than for younger women. The rates of psychiatric disorders in older women are higher than in older men, ...

  6. Spatial navigation in young versus older adults

    Directory of Open Access Journals (Sweden)

    Ivana Gazova

    2013-12-01

    Full Text Available Older age is associated with changes in the brain, including the medial temporal lobe, which may result in mild spatial navigation deficits, especially in allocentric navigation. The aim of the study was to characterize the profile of real-space allocentric (world-centered, hippocampus dependent and egocentric (body-centered, parietal lobe dependent navigation and learning in young vs. older adults, and to assess a possible influence of gender. We recruited healthy participants without cognitive deficits on standard neuropsychological testing, white matter lesions or pronounced hippocampal atrophy: 24 young participants (18-26 years old and 44 older participants stratified as participants 60-70 years old (n=24 and participants 71-84 years old (n=20. All underwent spatial navigation testing in the real-space human analog of the Morris Water Maze, which has the advantage of assessing separately allocentric and egocentric navigation and learning. Of the 8 consecutive trials, trials 2-8 were used to reduce bias by a rebound effect (more dramatic changes in performance between trials 1 and 2 relative to subsequent trials. The participants who were 71-84 years old (p< .001, but not those 60-70 years old, showed deficit in allocentric navigation compared to the young participants. There were no differences in egocentric navigation. All three groups showed spatial learning effect (p´s ≤.01. There were no gender differences in spatial navigation and learning. The linear regression limited to older participants showed linear (β=0.30, p=.045 and quadratic (β=0.30, p=.046 effect of age on allocentric navigation. There was no effect of age on egocentric navigation. These results demonstrate that navigation deficits in older age may be limited to allocentric navigation, whereas egocentric navigation and learning may remain preserved. This specific pattern of spatial navigation impairment may help differentiate normal aging from prodromal Alzheimer

  7. A study of relationships between bone-related vitamins and minerals, related risk markers, and subsequent mortality in older British people: the National Diet and Nutrition Survey of People Aged 65 Years and Over

    OpenAIRE

    Bates, C. J.; Hamer, M.; Mishra, G.D.

    2011-01-01

    Summary Follow-up of a British national survey of older people found that in men, all-cause mortality was predicted by baseline plasma concentrations of phosphorus, albumin, creatinine and α1-antichymotrypsin, and food energy intake and in women by plasma alkaline phosphatase, creatinine, α1-antichymotrypsin, 25-hydroxy-vitamin D (marginally), and phosphorus intake. Introduction Predictive power, for all-cause mortality, of bone-related vitamin and mineral indices and intakes, measured at bas...

  8. Lifelong Learning and Older Workers

    Science.gov (United States)

    Karmel, Tom; Woods, Davinia

    2004-01-01

    Discussion about Australia's ageing population has focused on the importance of increasing labour force participation rates of older people. This paper examines the influence of education and training on the participation of older people in the labour market, and the pay-off of undertaking education and training as an older-person compared to…

  9. Optimal breast cancer screening strategies for older women: current perspectives

    Directory of Open Access Journals (Sweden)

    Braithwaite D

    2016-02-01

    Full Text Available Dejana Braithwaite,1 Joshua Demb,1 Louise M Henderson2 1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, 2Department of Radiology, University of North Carolina, Chapel Hill, NC, USA Abstract: Breast cancer is a major cause of cancer-related deaths among older women, aged 65 years or older. Screening mammography has been shown to be effective in reducing breast cancer mortality in women aged 50–74 years but not among those aged 75 years or older. Given the large heterogeneity in comorbidity status and life expectancy among older women, controversy remains over screening mammography in this population. Diminished life expectancy with aging may decrease the potential screening benefit and increase the risk of harms. In this review, we summarize the evidence on screening mammography utilization, performance, and outcomes and highlight evidence gaps. Optimizing the screening strategy will involve separating older women who will benefit from screening from those who will not benefit by using information on comorbidity status and life expectancy. This review has identified areas related to screening mammography in older women that warrant additional research, including the need to evaluate emerging screening technologies, such as tomosynthesis among older women and precision cancer screening. In the absence of randomized controlled trials, the benefits and harms of continued screening mammography in older women need to be estimated using both population-based cohort data and simulation models. Keywords: aging, breast cancer, precision cancer screening

  10. A Multi-billion Parcel Atmospheric Trajectory Model

    Science.gov (United States)

    Cruz, C.; Clune, T. L.; Lait, L. R.; Ranawake, U.; Burns, R. W.

    2009-12-01

    We present a new parallel implementation of an atmospheric trajectory modelling framework which provides improved numerical accuracy, greater flexibility for specifying experiments, and sufficient raw performance to simultaneously simulate billions of parcel trajectories on suitable computing platforms. The application is parallelized using the Message Passing Interface (MPI) library and can scale efficiently on a wide variety of modern computing platforms. The ability to treat such large numbers of parcels is expected to enable a new generation of experiments to explore questions related to global stratosphere-troposphere exchange, age-of-air spectra, and transport of trace gases and aerosols. The modelling framework is written in C++ for easy integration with other computing technologies. It also provides a great deal of flexibility by allowing users to select from (or add to) alternative subclasses for vertical coordinates (pressure, potential temperature), integration schemes (Runge-Kutta, Euler), meteorological data sources (NCEP/NCAR Reanalsyis, MERRA), data interpolation methods (linear, log-linear, splines), and output (parcel histories, summary statistics, min/max quantities encountered). Significantly improved numerical accuracy, especially near the poles, is provided by expressing integration in terms of purely geometric constructs which avoid various complications associated with spherical coordinates near the poles. The entire package has been rigorously developed using Test-Driven Development (TDD) which both provides confidence in the implementation and should also assist other developers that wish to extend the framework. Several tests are performed to demonstrate the fourth-order Runge-Kutta integration scheme with our spherical geometric constructs. Tilted solid body rotation provides a baseline synthetic wind field for assessing model performance, and a time-varying case is used to examine the errors introduced by interpolating linearly in time

  11. Older Consumers in Malaysia

    OpenAIRE

    Phillips, David R.; Fon Sim Ong

    2007-01-01

    The main objective of this study was to understand the concerns and problems faced by older people in an industrializing middle-income country, Malaysia, in their process of acquiring products to meet their everyday needs. Respondents aged 55 and over were interviewed in eight states throughout Peninsular Malaysia providing 1356 usable questionnaires; two-thirds from urban and one-third from rural areas. Education, health status, and life satisfaction were recorded. Service patronage behaviou...

  12. Rhinitis in Older Adults

    OpenAIRE

    Nyenhuis, Sharmilee; Mathur, Sameer K.

    2013-01-01

    Rhinitis symptoms of rhinorrhea, congestion, sneezing, nasal/ocular pruritis, and postnasal drainage can significantly affect the quality of life for older adults. As the US population ages, it will be increasingly important for healthcare providers to effectively diagnose and manage rhinitis. Rhinitis is categorized broadly into allergic rhinitis and non-allergic rhinitis. Environmental changes and avoidance measures are a primary means of intervention. In addition, there are several topical...

  13. Missing billions. How the Australian government's climate policy is penalising farmers

    International Nuclear Information System (INIS)

    The Climate Institute analysis suggests ratifying the Kyoto Protocol and implementing a national emissions trading scheme today could provide Australian farmers with an income of $1.8 billion over the period 2008-2012, due to the emissions saved by limiting land clearing. Separately, a report to the National Farmers Federation by the Allen Consulting Group earlier this year concluded that a carbon emission trading system which recognised Kyoto Protocol rules could create an additional income stream of $0.7-0.9 billion over a five year period from revenue to farmers from forestry sinks. These two studies suggest that ratification of the Kyoto Protocol and the introduction of a national emissions trading scheme could provide farmers an income stream in the order of $2.5 billion. A central tenet of the Federal Government's greenhouse policy for over a decade has been to not ratify Kyoto, but to meet its Kyoto target - a national emissions increase of 8% from 1990 levels, in the period 2008-2012. Australia's National Greenhouse Gas Accounts show that farmers, by reducing land clearing rates since 1990, have offset substantial increases in greenhouse gas emissions from other sectors, mainly energy. Official Federal Government projections show that without land clearing reductions, Australia's greenhouse emissions would be 30% above 1990 levels by 2010. Australia's farmers have been responsible for virtually the entire share of the nation's greenhouse gas emissions reductions, but their efforts, worth around $2 billion, have not been recognised or financially rewarded by the Government. By reducing land clearing, farmers have already reduced greenhouse gas emissions by about 75 million tonnes since 1990. By 2010, the savings are projected to be about 83 million tonnes. This level of emissions reductions is equivalent to eliminating the total annual emissions of New Zealand or Ireland. Over that same period, emissions from energy and transport have and continue to sky

  14. 高龄食管癌患者术后早期肠内营养的临床研究%Early postoperative enteral nutrition with esophageal cancer in patients aged 70 years and older

    Institute of Scientific and Technical Information of China (English)

    夏晓明; 施仁忠; 张亚峰

    2010-01-01

    目的 探讨高龄食管癌患者术后早期肠内营养的意义.方法 选取62例70岁以上食管癌患者,随机分肠内营养(EN)组和肠外营养(PN)组,对术前、术后第1天、术后第8天的血清白蛋白、前白蛋白、外周血淋巴细胞、血清免疫球蛋白(IgG、IgM、IgA)、补体C3和C4进行测定.并观察术后感染性并发症和心血管并发症发生状况.结果 术后第8天2组比较,tALB=2.535、tPA=2.880、t淋巴细胞数=2.720、tIgA=2.166、tIgM=2.065、tC3=4.103、tC4=2.478,P均<0.05,表明EN组在改善营养状况、增强免疫力方面优于PN组.术后并发症比较,x2感染性并发症=4.24、x2心血管并发症=15.55,P均<0.05,表明EN组并发症的发生率低于PN组.结论 高龄食管癌患者术后早期肠内营养能明显改善患者营养状况、增强机体免疫力、减少并发症的发生率.%Objective To investigate the significance of early postoperative enteral nutrition with esophageal cancer in the elderly. Methods A total of 62 cases of esophageal cancer patients aged 70 years and older were randomly divided into the enteral nutrition(EN)group and the parenteral nutrition(PN)group. In preoperative and the first day and eighth day of postoperative serum albumin,prealbumin,peripheral blood lymphocytes,serum immunoglobulin(IgG,IgM,IgA),complement C3 and C4 were measured,and the postoperative infectious complications and cardiovascular complications were observed. Results During the eighth day after operation,the statistic analysis of the data between EN group and PN group showed: tALB = 2. 535,tPA = 2. 880,tLymphocyte =2. 720,tIgA =2. 166,tIgM =2. 065 ,tC3 =4. 103 ,tC4 =2. 478,P <0. 05. The result indicated that the EN group was better than the PN group in improving the nutritional status of patients,strengthened the immune system. The complication comparison between the two groups after operation: x2 Infection = 4. 24,x2 Cardiovascular =15.55,P < 0. 05. The result indicated that

  15. Adaptation of the older worker to occupational challenges.

    Science.gov (United States)

    Moyers, Penelope A; Coleman, Shelley D

    2004-01-01

    The occupational adaptation practice model guided the search for and the analysis of the literature on the older worker. The purpose of this literature review was to: identify the occupational challenges that older workers experience, determine ways in which the occupational therapist can promote the occupational adaptation of older workers, and articulate the research and policy changes implied in the model related to health and improved productivity. The analysis of the worker's personal characteristics, work tasks, and environments highlighted the types of occupational challenges that may overwhelm the older worker's adaptive capacity. Straining adaptive capacity of the older worker leads to degradation in levels of mastery. The occupational therapist and others could assist the older worker to achieve relative mastery in response to occupational challenges through ergonomic solutions, training, assistive devices, management policy, and health promotion. Combined efforts of the employer, of the occupational therapist, and of the older work to capitalize on the older worker's years of experience, existing skills, and knowledge facilitates higher job satisfaction, better performance, and an increased sense of well-being in the older worker. PMID:15004340

  16. Late life gambling: the attitudes and behaviors of older adults.

    Science.gov (United States)

    McNeilly, D P; Burke, W J

    2000-01-01

    For a significant number of retired older adults (aged 65+), gambling has become a new form of recreation and entertainment. While prevalence studies have examined the incidence of problem gambling in other age groups, little research attention has been paid to the impact of gambling on older adults since the increase in availability and accessibility of legalized gambling within the last ten years. This study investigated the prevalence of problem gambling behaviors (SOGS-R), depression (GDS-15), levels of life satisfaction (SWLS), and motivations for gambling among older adults. A total of 315 older adults completed the study questionnaire and were grouped and analyzed according to those sampled from gambling venues and those from within the community. Results of the study found the most frequent accession and spending on several types of gambling occurred among older adults who were sampled at gambling venues. Older adults who were sampled at gambling venues were also found more likely to have higher levels of disordered gambling than older adults from the community, as measured by the SOGS-R. Relaxation, boredom, passing time, and getting away for the day were also the most likely reported motivations for the older adults who were gambling patrons. These findings provide an initial profile of older adults and their attitudes, motivations and gambling behaviors. PMID:14634305

  17. Fitness for Those with Disabilities and Older Adults

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Healthy New Year Fitness for Those with Disabilities and Older Adults Past Issues / Winter 2016 Table of Contents Fitness for Those with Disabilities Physical activity is great ...

  18. Metabolic and Cardiovascular Responses during Aquatic Exercise in Water at Different Temperatures in Older Adults

    Science.gov (United States)

    Bergamin, Marco; Ermolao, Andrea; Matten, Sonia; Sieverdes, John C.; Zaccaria, Marco

    2015-01-01

    Purpose: The aim of this study was to investigate the physiological responses during upper-body aquatic exercises in older adults with different pool temperatures. Method: Eleven older men (aged 65 years and older) underwent 2 identical aquatic exercise sessions that consisted of 3 upper-body exercises using progressive intensities (30, 35, and 40…

  19. Drug-related falls in older patients: Implicated drugs, consequences, and possible prevention strategies

    NARCIS (Netherlands)

    M.R. de Jong (Marlies R.); M. van der Elst (Maarten); K.A. Hartholt (Klaas)

    2013-01-01

    textabstractFalls are the leading cause of injuries among older adults, aged 65 years and older. Furthermore, falls are an increasing public health problem because of ageing populations worldwide due to an increase in the number of older adults, and an increase in life expectancy. Numerous studies h

  20. Effects of Service Barriers on Health Status of Older Chinese Immigrants in Canada

    Science.gov (United States)

    Lai, Daniel W. L.; Chau, Shirley B.

    2007-01-01

    The authors examine the effects of service barriers on the health status of older Chinese immigrants in Canada. A survey was completed in seven Canadian cities by a random sample of 2,214 older Chinese immigrants age 55 years or older. Service barriers related to administrative problems, personal attitudes, and circumstantial difficulties were…

  1. Forearm vascular responses to mental stress in healthy older adults

    OpenAIRE

    Heffernan, Matthew J.; Patel, Hardikkumar M.; Muller, Matthew D.

    2013-01-01

    Abstract Forearm vascular conductance (FVC) increases in response to mental stress (verbal mental arithmetic) in young people. However, the effect of healthy aging and mental stress on FVC is unknown. In this study, we tested the hypothesis that FVC and cutaneous vascular conductance (CVC) would be attenuated in older adults compared to young adults. In 13 young (27 ± 1 year) and 11 older (62 ± 1 year) subjects, we quantified heart rate (HR), mean arterial pressure (MAP), FVC (Doppler ultraso...

  2. Attitudes and Experiences With Older Adults: A Case for Service Learning for Undergraduates.

    Science.gov (United States)

    Obhi, Hardeep K; Woodhead, Erin L

    2016-01-01

    The current study examined whether relationship quality with older adults currently and in childhood, as well as experience with older adults, was associated with biases toward older adults and interest in working with older adults as a possible career area. The authors sampled undergraduate students (N = 753, M = 18.97 years, SD = 2.11 years) from a Northern California university. In hierarchical regression analyses, higher perceived quality of relationships with older adult family members, higher perceived social support, and lower perceived conflict from relationships with older adults was significantly associated with positive attitudes toward older adults. Interest in working with older adults was significantly associated with taking courses in aging, providing care to an older adult, and volunteering with older adults. These results suggest that positive relationships with older adults are useful in reducing biases, though student interactions with older adults are key in helping to promote interest in working with older adults. PMID:26596911

  3. Tuberculosis in Older Adults.

    Science.gov (United States)

    Rajagopalan, Shobita

    2016-08-01

    Tuberculosis (TB) remains one of the world's most lethal infectious diseases. Preventive and control strategies among other high-risk groups, such as the elderly population, continues to be a challenge. Clinical features of TB in older adults may be atypical and confused with age-related diseases. Diagnosis and management of TB in the elderly person can be difficult; treatment can be associated with adverse drug reactions. This article reviews the current global epidemiology, pathogenesis, clinical characteristics, diagnosis, management, and prevention of Mycobacterium tuberculosis infection in community-dwelling and institutionalized aging adults. PMID:27394018

  4. Resilience among older women.

    Science.gov (United States)

    Wagnild, G; Young, H M

    1990-01-01

    This qualitative study was designed to identify and describe characteristics of successfully adjusted older women. The participants reported a recent major loss and were considered successfully adjusted as evidenced by social involvement in a senior center, a mid level to high level of morale and self-report. Using a grounded theory approach, five underlying themes were identified: equanimity, self-reliance, existential aloneness, perseverance and meaningfulness. These themes are thought to constitute resilience. Lateral grounding of the concept resilience is accomplished by comparison with philosophical writings of Frankl, Bettelheim, Frank, May and von Witzleben. Resilience is important in late life as a component of successful psychosocial adjustment. PMID:2292448

  5. Differences between younger and older patients with childhood hodgkin lymphoma.

    Science.gov (United States)

    Pourtsidis, Apostolos; Doganis, Dimitrios; Baka, Margarita; Bouhoutsou, Despina; Varvoutsi, Maria; Synodinou, Maria; Strantzia, Katerina; Kosmidis, Helen

    2013-09-01

    From 1979 to 2006, 74 children with Hodgkin's lymphoma were treated at our center. Among them, 15 (14 boys and 1 girl) and 59 (33 boys and 26 girls) patients were younger and older than 8 years, respectively. Six (40%) children among younger patients and 26 (44%) among older patients had advanced stage disease. We detected 3 (20%) relapses among younger patients and 5 (8.5%) among the older patients. All of younger patients are alive whereas three of the older patients have died. Second malignancy developed in one and three children among younger and older patients, respectively. The only difference that was detected concerning the age was a male predominance among the younger patients. PMID:23941743

  6. Older Consumers in Malaysia

    Directory of Open Access Journals (Sweden)

    David R. Phillips

    2007-07-01

    Full Text Available The main objective of this study was to understand the concerns and problems faced by older people in an industrializing middle-income country, Malaysia, in their process of acquiring products to meet their everyday needs. Respondents aged 55 and over were interviewed in eight states throughout Peninsular Malaysia providing 1356 usable questionnaires; two-thirds from urban and one-third from rural areas. Education, health status, and life satisfaction were recorded. Service patronage behaviour was examined for four main categories of commonly-sought consumer goods: groceries, health supplements, apparel, eating outlets, plus selected services (public transport, vacation packages and financial services. The findings showed that older adults in Malaysia are rather discerning consumers. Many respondents are price conscious and have developed consumer attitudes with regard to attitude of staff and assistance rendered. Many display a good ability to discriminate and to select, especially on the basis of price and durability of products and many appear to be acting as effectively as consumers in any other age group.

  7. NREL Helps Clean Cities Displace Billions of Gallons of Petroleum, One Vehicle at a Time (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2010-10-01

    With more than 15 years and nearly 3 billion gallons of displaced petroleum under its belt, the Clean Cities program relies on the support and expertise of the National Renewable Energy Laboratory (NREL). An initiative of the U.S. Department of Energy (DOE), Clean Cities creates public-private partnerships with a common mission: to reduce petroleum consumption in the transportation sector. Since the inception of Clean Cities in 1993, NREL has played a central role in supporting the program, an effort that stems from the laboratory's strategy to put scientific innovation into action in the marketplace.

  8. Providing safe drinking water to 1.2 billion unserved people

    Energy Technology Data Exchange (ETDEWEB)

    Gadgil, Ashok J.; Derby, Elisabeth A.

    2003-06-01

    Despite substantial advances in the past 100 years in public health, technology and medicine, 20% of the world population, mostly comprised of the poor population segments in developing countries (DCs), still does not have access to safe drinking water. To reach the United Nations (UN) Millennium Goal of halving the number of people without access to safe water by 2015, the global community will need to provide an additional one billion urban residents and 600 million rural residents with safe water within the next twelve years. This paper examines current water treatment measures and implementation methods for delivery of safe drinking water, and offers suggestions for making progress towards the goal of providing a timely and equitable solution for safe water provision. For water treatment, based on the serious limitations of boiling water and chlorination, we suggest an approach based on filtration coupled with ultraviolet (UV) disinfection, combined with public education. Additionally, owing to the capacity limitations for non-governmental organizations (NGOs) to take on this task primarily on their own, we suggest a strategy based on financially sustainable models that include the private sector as well as NGOs.

  9. Older people's perceptions about symptoms.

    OpenAIRE

    R. Morgan; Pendleton, N; Clague, J E; Horan, M A

    1997-01-01

    BACKGROUND: Little is known of the nature and origins of the attitudes that older people have towards ageing, disease, and medical treatments. Several studies on older people in the community have suggested under-reporting of symptoms. There may be several reasons for this, including the possibility that some older people regard disease processes as a natural feature of ageing and, consequently, feel that medical intervention may have little to offer. AIM: To investigate the perceptions of ol...

  10. Getting older can be exhausting

    OpenAIRE

    Mittal, Rohit; Ford, Mandy L.; Coopersmith, Craig M.

    2014-01-01

    Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary ...

  11. 180 billion pounds to fix transport or save New Labour?

    International Nuclear Information System (INIS)

    This article considers that the UK government's ten-year transport plan, launched in July 2000, is as much about boosting New Labour's popularity as it is about addressing the nation's transport problems

  12. Forecast 1978: $45.2-Billion for R and D

    Science.gov (United States)

    Mosbacher, C. J.

    1978-01-01

    Discusses Research and Development (R&D) funding trends from industry and the federal government. A real increase for the third consecutive year is forecast for 1978, if inflation stays below 7.9 percent. (SL)

  13. Getting older can be exhausting.

    Science.gov (United States)

    Mittal, Rohit; Ford, Mandy L; Coopersmith, Craig M

    2014-01-01

    Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission. PMID:25184737

  14. Addressing violence against older women.

    Science.gov (United States)

    2016-07-01

    Domestic abuse is widespread and indiscriminate, causing health-related concerns and mental health issues in older women. Research suggests their needs are not met by existing services. This article examines physical and mental health issues faced by older women as a result of abusive relationships, and the barriers that exist to seeking help. Healthcare professionals can facilitate therapeutic engagement of older women living with domestic abuse. Refuges and related interventions are limited, but developing a stepped approach, tailored to older women's needs, could help. PMID:27369732

  15. [Management of older adults with COPD].

    Science.gov (United States)

    Hattori, Kumiko; Kida, Kozui

    2016-05-01

    In older adults, the clinical condition of COPD is complicated and treatment often becomes difficult, because of existence of multimorbidity, such as nutritional deficiencies, thinness, sarcopenia, osteoporosis, cardiovascular disease, depression and cognitive impairment. Consideration based on each of coexistence is needed in the management of older adults with COPD. In end period of COPD, sleep disorder, depressive state and decline of ADL are often shown, in addition to the respiratory symptoms, such as dyspnea, cough and sputum. Financial strain for the nursing cost and medical equipment cost tend to become big year by year, utilization of social resources (i.e. application of respiratory disabilities and an insurance of the elderly care) is need to be considered. PMID:27254959

  16. Filipino Older Adults’ Beliefs About Exercise Activity

    Science.gov (United States)

    Ceria-Ulep, Clementina D.; Serafica, Reimund C.; Tse, Alice

    2016-01-01

    PURPOSE This study explored how the older traditional Filipino adults 65 years old and above living in Honolulu, Hawaii, describe their beliefs regarding exercise activity. The location of this research setting is unique because a blending of traditional Filipino culture exists within an acculturated social setting. The Filipino older adults who have relocated to this U.S. location may have also stayed close to their own cultural traditions. METHODOLOGIES A perception of exercise activity was generated through the lens of 47 participants using qualitative methodology. FINDINGS While focusing on the older adults’ beliefs about exercise activity, it became evident that exercise may have been seen as a proxy measure of physical activity. The study revealed four main domains: balancing barriers against benefits; engaging capabilities; intervening factors; and defining exercise. The data suggest that the four themes are juxtaposed among each other, with overarching social obligations to the kin group governing the older adults’ engagement in what constitutes structured exercise by Western definition. IMPLICATIONS Further investigation is needed to conceptualize what types of physical activities traditional Filipino elders perceive as exercise, and whether these activities fall into the Western definition of exercise. PMID:22029767

  17. Acute myeloid leukemia in the older patient.

    Science.gov (United States)

    Godwin, John E; Smith, Scott E

    2003-10-15

    Acute myeloid leukemia (AML) is an extremely heterogeneous disorder. The biology of AML is incompletely understood, but much data indicates that older patients have a more biologically diverse and chemotherapy resistant form of AML that is quite different from that seen in the younger patients. Approximately 60% of AML cases are in patients greater than 60 years of age, so the predominant burden is in older patients. This problem will be magnified in the future, because the US population is both growing and aging. When one examines the treatment outcomes of older AML patients over the last three decades, there is little progress in long-term survival. Nine major published randomized placebo controlled trials of myeloid growth factors given during induction for AML have been conducted. All of these trials with one exception demonstrated no significant impact on the clinical outcomes of complete response (CR) rate, disease-free, and overall survival. However, the duration of neutropenia was consistently and uniformly reduced by the use of growth factor in all nine of these trials. Because of the favorable impact of the colony-stimulating factors (CSFs) on resource use, antibiotic days, hospital days, etc., it can be more economical and beneficial to use CSFs in AML than to withhold use. The overall dismal outlook for the older AML patient can only be altered by clinical trials with new therapeutic agents. New cellular and molecularly targeted agents are entering clinical trials and bring hope for progress to this area of cancer therapy. PMID:14563517

  18. Depression among older adults with diabetes mellitus

    OpenAIRE

    Park, Mijung; Reynolds, Charles F.

    2014-01-01

    Depression is among the leading causes of decreased disability-adjusted life years in the world1 and a serious public health problem.2 Older adults with DM experience greater risk for comorbid depression compared to those who do not have DM.3 Having DM increases the risk of subsequent development or recurrence of depression. Conversely, history of depression increases the risk for new onset DM.4 As an unwanted co-traveler of DM, undetected, untreated or undertreated depression impinges an ind...

  19. Polypharmacy among older adults in Tehran

    OpenAIRE

    B. Ahmadi; M. Alimohamadian; Mahmoodi, M

    2006-01-01

    Background: Multiple drug use is frequently considered to be hazardous for the elderly because of their greater vulnerability to the complications. The purpose of this study was to determine the prevalence of polypharmacy in Tehran and to assess the relative demographic characteristics of patients. Methods: In a cross-sectional study 400 persons aging 55 years and older were interviewed in order to determine the presence of polypharmacy (daily intake of three or more drugs). The cases were ra...

  20. U.S. Billion-Ton Update: Biomass Supply for a Bioenergy and Bioproducts Industry

    Energy Technology Data Exchange (ETDEWEB)

    Downing, Mark [ORNL; Eaton, Laurence M [ORNL; Graham, Robin Lambert [ORNL; Langholtz, Matthew H [ORNL; Perlack, Robert D [ORNL; Turhollow Jr, Anthony F [ORNL; Stokes, Bryce [Navarro Research & Engineering; Brandt, Craig C [ORNL

    2011-08-01

    The report, Biomass as Feedstock for a Bioenergy and Bioproducts Industry: The Technical Feasibility of a Billion-Ton Annual Supply (generally referred to as the Billion-Ton Study or 2005 BTS), was an estimate of 'potential' biomass based on numerous assumptions about current and future inventory, production capacity, availability, and technology. The analysis was made to determine if conterminous U.S. agriculture and forestry resources had the capability to produce at least one billion dry tons of sustainable biomass annually to displace 30% or more of the nation's present petroleum consumption. An effort was made to use conservative estimates to assure confidence in having sufficient supply to reach the goal. The potential biomass was projected to be reasonably available around mid-century when large-scale biorefineries are likely to exist. The study emphasized primary sources of forest- and agriculture-derived biomass, such as logging residues, fuel treatment thinnings, crop residues, and perennially grown grasses and trees. These primary sources have the greatest potential to supply large, reliable, and sustainable quantities of biomass. While the primary sources were emphasized, estimates of secondary residue and tertiary waste resources of biomass were also provided. The original Billion-Ton Resource Assessment, published in 2005, was divided into two parts-forest-derived resources and agriculture-derived resources. The forest resources included residues produced during the harvesting of merchantable timber, forest residues, and small-diameter trees that could become available through initiatives to reduce fire hazards and improve forest health; forest residues from land conversion; fuelwood extracted from forests; residues generated at primary forest product processing mills; and urban wood wastes, municipal solid wastes (MSW), and construction and demolition (C&D) debris. For these forest resources, only residues, wastes, and small

  1. Emergency Department and Older Adult Motor Vehicle Collisions

    Directory of Open Access Journals (Sweden)

    Lotfipour, Shahram

    2013-11-01

    Full Text Available In 2009, the Center for Disease Control and Prevention reported there were 33 million licensed drivers 65 years and older in the U.S. This represents a 23 percent increase from 1999, number that is predicted to double by 2030. Although, motor vehicle collisions (MVC-related to emergency department (ED visits for older adults are lower per capita than for younger adults, the older-adults MVCs require more resources, such as additional diagnostic imaging and increased odds of admission. Addressing the specific needs of older-adults could lead to better outcomes yet not enough research currently exists. It is important to continue training emergency physicians to treat the increasing older-patient population, but its also imperative we increase our injury prevention and screening methodology. We review research findings from the article: Emergency Department Visits by Older Adults for Motor Vehicle Collisions: A Five-year national study, with commentary on current recommendation and policies for the growing older-adult driving population. [West J Emerg Med.2013;14(6:582–584.

  2. A cohort study on the evolution of psychosocial problems in older patients with breast or colorectal cancer: comparison with younger cancer patients and older primary care patients without cancer

    OpenAIRE

    Deckx, Laura; van Abbema, Doris L.; van den Akker, Marjan; Van Den Broeke, Carine; van Driel, Mieke; Bulens, Paul; Tjan-Heijnen, Vivianne C. G.; Kenis, Cindy; de Jonge, Eric T.; Houben, Bert; Buntinx, Frank

    2015-01-01

    Background Although older cancer survivors commonly report psychosocial problems, the impact of both cancer and ageing on the occurrence of these problems remains largely unknown. The evolution of depression, cognitive functioning, and fatigue was evaluated in a group of older cancer patients in comparison with a group of younger cancer patients and older persons without cancer. Methods Older (≥70 years) and younger cancer patients (50 – 69 years) with breast or colorectal cancer stage I - II...

  3. Marketing to Older American Consumers.

    Science.gov (United States)

    Mertz, Barbara; Stephens, Nancy

    1986-01-01

    Examined older adults as a potential market for American businesses. Data indicate that in terms of size and income, senior citizens comprise a substantial buying group. Their buying styles, product and service needs, and shopping behavior vary from younger adults and within the older adult population. Strategies for successful marketing are…

  4. Quitting Smoking for Older Adults

    Science.gov (United States)

    ... Related Topics Alcohol Use and Older Adults COPD Lung Cancer The information in this topic was provided by the National Cancer Institute Topic last reviewed: June 2014 For an enhanced version of this page please turn Javascript on. Quitting Smoking for Older ...

  5. How To Manage Older Workers.

    Science.gov (United States)

    American Association of Retired Persons, Washington, DC.

    Most older workers continue to work hard and perform well; those who do not often perceive that their opportunities for promotion and increased earnings are limited. Six principles of management particularly apply to older workers: (1) recognize that needs can be powerful motivators; (2) link need satisfaction to job performance; (3) set specific,…

  6. Obama Asks Congress for $1.9 Billion to Battle Zika Virus

    Science.gov (United States)

    ... Congress for $1.9 Billion to Battle Zika Virus Money would go toward mosquito-control programs, vaccine development and tests to better spot the virus To use the sharing features on this page, ...

  7. The economic downturn and its lingering effects reduced medicare spending growth by $4 billion in 2009-12.

    Science.gov (United States)

    Dranove, David; Garthwaite, Craig; Ody, Christopher

    2015-08-01

    Previous work has found a strong connection between the most recent economic recession and reductions in private health spending. However, the effect of economic downturns on Medicare spending is less clear. In contrast to studies involving earlier time periods, our study found that when the macroeconomy slowed during the Great Recession of 2007-09, so did Medicare spending growth. A small (14 percent) but significant share of the decline in Medicare spending growth from 2009 to 2012 relative to growth from 2004 to 2009 can be attributed to lingering effects of the recession. Absent the economic downturn, Medicare spending would have been $4 billion higher in 2009-12. A major reason for the relatively small impact of the macroeconomy is the relative lack of labor-force participation among people ages sixty-five and older. We estimate that if they had been working at the same rate as the nonelderly before the recession, the effect of the downturn on Medicare spending growth would have been twice as large. PMID:26240251

  8. FlashGraph: Processing Billion-Node Graphs on an Array of Commodity SSDs

    OpenAIRE

    Zheng, Da; Mhembere, Disa; Burns, Randal; Vogelstein, Joshua; Carey E. Priebe; Szalay, Alexander S.

    2014-01-01

    Graph analysis performs many random reads and writes, thus, these workloads are typically performed in memory. Traditionally, analyzing large graphs requires a cluster of machines so the aggregate memory exceeds the graph size. We demonstrate that a multicore server can process graphs with billions of vertices and hundreds of billions of edges, utilizing commodity SSDs with minimal performance loss. We do so by implementing a graph-processing engine on top of a user-space SSD file system desi...

  9. 1.3 Billion People: A Weighty Responsibility——China's Population Policy

    Institute of Scientific and Technical Information of China (English)

    LURUCAI

    2005-01-01

    A sample survey of the 2004 population increase releasedby the State Statistics Bureau shows that by the end of 2004 the total population of the Chinese mainland was 1.29988 billion, and that it was increasing by 208,000 people per day. According to this data,on January 6, 2005,China's population(excluding HongKong, Macao andTaiwan) reached 1.3 billion.

  10. Environmentally Benign Coal Mining: Target One Billion Tonne Coal Production by CIL by 2019-20

    Directory of Open Access Journals (Sweden)

    Gurdeep Singh1,2 and

    2016-08-01

    Full Text Available Coal is the most abundant fuel resource in India. Coal is the major source of energy and is the principal contributor for the industrial growth of the developing nation like India. Coal is a bridge component in a current, balanced energy group. It is connection for the future as a vital low cost energy solution for achieving sustainability challenges for competing with the developed countries. The largest consumer of coal in India is power sector, and the industrial sector is coming next to power sector. The major consumption of coal in India is in steel plant, cement plant and brick-manufacturing units.52%of primary energy is coal dependent1.About 66% of India's power generation is based upon coal production1. While coal is considered the most significant element for the growth of country, it faces major and massive social and environmental issues. Environmental worries are the most important parameter for the coal industry’s future. In comparison to the other fossil fuels, coal is more pollution causing and less energy efficient. Coal has an important role in fulfillment of current needs. 212.10 Million Tonnes of coal was imported in the financial year 2014-152.The coal demand will be increasing due to increase in electricity demand of the country. Coal India being the largest producer of coal in India has to plan accordingly to fulfill the coal demand of country. A road map for enhancement of coal production up to 1 Billion of coal by 2019-2020 has been prepared by Coal India3. Due to coal mining the key environmental impacts are on air, water, land, forest, biodiversity, and climate etc. The biggest challenge is to put on the innovative technologies in the most efficient and environmentally friendly manner and to solve social issues by taking care of the implementation of rehabilitation and resettlement (R&R.Thrust is now to promote inclusive growth of mining areas by adequate corporate social responsibilities (CSR activities4,5. Thus the

  11. Large data analysis: automatic visual personal identification in a demography of 1.2 billion persons

    Science.gov (United States)

    Daugman, John

    2014-05-01

    The largest biometric deployment in history is now underway in India, where the Government is enrolling the iris patterns (among other data) of all 1.2 billion citizens. The purpose of the Unique Identification Authority of India (UIDAI) is to ensure fair access to welfare benefits and entitlements, to reduce fraud, and enhance social inclusion. Only a minority of Indian citizens have bank accounts; only 4 percent possess passports; and less than half of all aid money reaches its intended recipients. A person who lacks any means of establishing their identity is excluded from entitlements and does not officially exist; thus the slogan of UIDAI is: To give the poor an identity." This ambitious program enrolls a million people every day, across 36,000 stations run by 83 agencies, with a 3-year completion target for the entire national population. The halfway point was recently passed with more than 600 million persons now enrolled. In order to detect and prevent duplicate identities, every iris pattern that is enrolled is first compared against all others enrolled so far; thus the daily workflow now requires 600 trillion (or 600 million-million) iris cross-comparisons. Avoiding identity collisions (False Matches) requires high biometric entropy, and achieving the tremendous match speed requires phase bit coding. Both of these requirements are being delivered operationally by wavelet methods developed by the author for encoding and comparing iris patterns, which will be the focus of this Large Data Award" presentation.

  12. Analysis of precious metals at parts-per-billion levels in industrial applications

    Science.gov (United States)

    Tickner, James; O'Dwyer, Joel; Roach, Greg; Smith, Michael; Van Haarlem, Yves

    2015-11-01

    Precious metals, including gold and the platinum group metals (notable Pt, Pd and Rh), are mined commercially at concentrations of a few parts-per-million and below. Mining and processing operations demand sensitive and rapid analysis at concentrations down to about 100 parts-per-billion (ppb). In this paper, we discuss two technologies being developed to meet this challenge: X-ray fluorescence (XRF) and gamma-activation analysis (GAA). We have designed on-stream XRF analysers capable of measuring targeted elements in slurries with precisions in the 35-70 ppb range. For the past two years, two on-stream analysers have been in continuous operation at a precious metals concentrator plant. The simultaneous measurement of feed and waste stream grades provides real-time information on metal recovery, allowing changes in operating conditions and plant upsets to be detected and corrected more rapidly. Separately, we have been developing GAA for the measurement of gold as a replacement for the traditional laboratory fire-assay process. High-energy Bremsstrahlung X-rays are used to excite gold via the 197Au(γ,γ‧)197Au-M reaction, and the gamma-rays released in the decay of the meta-state are then counted. We report on work to significantly improve accuracy and detection limits.

  13. Nordic energy co-operation can save the equivalent of 4 - 10 billion USD

    International Nuclear Information System (INIS)

    Better co-ordination of the energy- and environment policies among the Nordic countries can be very profitable from the socio-economic point of view and facilitate the fulfilment of the Kyoto agreement. A Swedish calculation shows that up to 10 billion USD can be saved by building a trans-nordic gasline and at the same time preparing for a common implementation of the Kyoto agreement, combined with increased electricity trade, improving the efficiency and increasing the use of renewable energy sources. The consumption of natural gas must then increase threefold the next 25 years. There is no alternative to natural gas of the same potential if coal and oil are to be replaced to reduce the emission of carbon dioxide. The importance of natural gas is further increased by the phase-out of nuclear energy in Sweden. After 2025 the use of natural gas will be reduced and in 2040 biomass energy, wind energy and solar energy will contribute as much as the natural gas, that is, 250 TWh. Throughout the entire period more than half of the electricity production will be hydropower. It is presupposed that the cogeneration sector and the district heating network are substantially expanded, even in South Norway. The Nordic energy system is quite flexible with respect to fulfilling future CO2 targets. Although the different Nordic countries have different commitments with respect to the Kyoto agreement, they will profit economically from acting jointly within the sum of their individual emission quotas

  14. If slow rate of health care spending growth persists, projections may be off by $770 billion.

    Science.gov (United States)

    Cutler, David M; Sahni, Nikhil R

    2013-05-01

    Despite earlier forecasts to the contrary, US health care spending growth has slowed in the past four years, continuing a trend that began in the early 2000s. In this article we attempt to identify why US health care spending growth has slowed, and we explore the spending implications if the trend continues for the next decade. We find that the 2007-09 recession, a one-time event, accounted for 37 percent of the slowdown between 2003 and 2012. A decline in private insurance coverage and cuts to some Medicare payment rates accounted for another 8 percent of the slowdown, leaving 55 percent of the spending slowdown unexplained. We conclude that a host of fundamental changes--including less rapid development of imaging technology and new pharmaceuticals, increased patient cost sharing, and greater provider efficiency--were responsible for the majority of the slowdown in spending growth. If these trends continue during 2013-22, public-sector health care spending will be as much as $770 billion less than predicted. Such lower levels of spending would have an enormous impact on the US economy and on government and household finances. PMID:23650316

  15. Carboxyhaemoglobin levels and their determinants in older British men

    OpenAIRE

    Lennon Lucy; Papacosta Olia; Whincup Peter; Haines Andrew

    2006-01-01

    Abstract Background Although there has been concern about the levels of carbon monoxide exposure, particularly among older people, little is known about COHb levels and their determinants in the general population. We examined these issues in a study of older British men. Methods Cross-sectional study of 4252 men aged 60–79 years selected from one socially representative general practice in each of 24 British towns and who attended for examination between 1998 and 2000. Blood samples were mea...

  16. Self-Management of Heart Disease in Older Adults

    OpenAIRE

    Huynh-Hohnbaum, Anh-Luu T.; Marshall, Lia; Villa, Valentine M.; Lee, Gi

    2015-01-01

    The American Heart Association estimates that 81% of people who die of coronary heart disease are 65 years old or older. The leading risk health behaviors include physical inactivity, poor diet, smoking and binge drinking. Using the 2011–2012 California Health Interview Survey (CHIS), this study looked at how self-management, which includes a plan developed by a medical professional and the confidence to manage one’s disease, may decrease negative risk behaviors in older adults. The presence ...

  17. Dimensions of self-rated health in older adults

    OpenAIRE

    Flávia Silva Arbex Borim; Anita Liberalesso Neri; Priscila Maria Stolses Bergamo Francisco; Marilisa Berti de Azevedo Barros

    2014-01-01

    OBJECTIVE To analyze the association between negative self-rated health and indicators of health, wellbeing and sociodemographic variables in older adults. METHODS Cross-sectional study that used data from a population-based health survey with a probability cluster sample that was carried out in Campinas, SP, Southeastern Brazil,, in 2008 and 2009. The participants were older adults (≥ 60 years) and the dependent variable was self-rated health, categorized as: excellent, very good, good, ...

  18. Social determinants of physical exercise in older men in Jamaica

    OpenAIRE

    Chloe Morris; Bourne, Paul A; Denise Eldemire-Shearer; Donovan A McGrowder

    2010-01-01

    Background : Background: Physical activity interventions have been demonstrated to improve health-related quality of life and to be of special benefit to older adults with specific chronic conditions including arthritis, hypertension, diabetes mellitus, and heart disease. Aim: This study examined the extent and social determinants of physical exercise in elderly men in Jamaica. Materials and Methods : A sample of 2,000 men 55 years of age and older was extracted from a total of 33,674 males i...

  19. How Older Adults Combine Medical and Experiential Notions of Depression

    OpenAIRE

    Wittink, Marsha N.; Dahlberg, Britt; Biruk, Crystal; Barg, Frances K.

    2008-01-01

    Past research has suggested that patients might not accept depression treatment in part because of differences between patient and doctor understandings of depression. In this article, we use a cultural models approach to explore how older adults incorporate clinical and experiential knowledge into their model of depression. We conducted semistructured interviews about depression with 19 patients aged 65 years and older who were identified by their physicians as depressed. We found that where...

  20. Physical Activity Interventions Among Older Adults: A Literature Review

    OpenAIRE

    Chase, Jo-Ana D.

    2013-01-01

    Physical activity (PA) is important in the management of chronic illness among older adults worldwide. Researchers have conducted several intervention studies to increase PA behavior in this population. This review of the past 12 years of relevant PA intervention research among adults age 60 and older systematically summarized research findings, identified characteristics of successful interventions, and proposed areas of future research. Twenty studies were reviewed for this paper, most empl...

  1. Exercise imagery and its correlates in older adults

    OpenAIRE

    Thøgersen-Ntoumani, Cecilie; Cumming, Jennifer; Ntoumanis, Nikos; Nikitaras, Nikitas

    2012-01-01

    Objectives The purpose of the present study was to test a structural model examining the interrelationships between exercise imagery, self-reported exercise behaviour and well-being in older adults. Design Cross-sectional survey. Method Participants were 499 older Greek adults (50.10% males) aged between 51 and 84 years (M age = 57.31; SD = 5.52) who completed questionnaires measuring exercise imagery use, exercise behaviour, subjective vitality, and physical self-worth. The ...

  2. Risk factors for septicemia-associated mortality in older adults.

    OpenAIRE

    Salive, M E; Wallace, R B; Ostfeld, A M; Satterfield, S.; Havlik, R J

    1993-01-01

    Septicemia is the 10th leading cause of death among older adults in the United States; its mortality rate has steadily increased over the past decades. Little is known about factors which predispose to septicemia mortality in the elderly. The authors investigated risk factors for septicemia-associated mortality in 10,269 older adults as part of a longitudinal study of three communities (East Boston, MA; New Haven, CT; and Iowa and Washington Counties, IA). During 6 years of followup, 177 pers...

  3. Linagliptin use in older individuals with type 2 diabetes

    OpenAIRE

    Pratley RE

    2014-01-01

    Richard E Pratley1–31Florida Hospital Diabetes Institute, 2Translational Research Institute for Metabolism and Diabetes, 3Sanford-Burnham Medical Research Institute, Orlando, FL, USAAbstract: Older people have the highest prevalence of type 2 diabetes mellitus (T2DM) of any age group and are thus frequent users of glucose-lowering agents. Because individuals 65 years or older are underrepresented in clinical studies, there is a lack of information...

  4. Factors associated with falls among older adults living in institutions

    OpenAIRE

    Damián, Javier; Pastor-Barriuso, Roberto; Valderrama-Gama, Emiliana; Pedro-Cuesta, Jesús de

    2013-01-01

    Background Falls have enormous impact in older adults. Yet, there is insufficient evidence regarding the effectiveness of preventive interventions in this setting. The objectives were to measure the frequency of falls and associated factors among older people living institutions. Methods Data were obtained from a survey on a probabilistic sample of residents aged ≥65 years, drawn in 1998-99 from institutions of Madrid (Spain). Residents, their caregivers, and facility physicians were intervie...

  5. Factors associated with falls among older adults living in institutions

    OpenAIRE

    Damián Javier; Pastor-Barriuso Roberto; Valderrama-Gama Emiliana; de Pedro-Cuesta Jesús

    2013-01-01

    Abstract Background Falls have enormous impact in older adults. Yet, there is insufficient evidence regarding the effectiveness of preventive interventions in this setting. The objectives were to measure the frequency of falls and associated factors among older people living institutions. Methods Data were obtained from a survey on a probabilistic sample of residents aged ≥65 years, drawn in 1998-99 from institutions of Madrid (Spain). Residents, their caregivers, and facility physicians were...

  6. Factors associated with excessive polypharmacy in older people

    OpenAIRE

    Walckiers, Denise; Van der Heyden, Johan; Tafforeau, Jean

    2015-01-01

    Background Older people are a growing population. They live longer, but often have multiple chronic diseases. As a consequence, they are taking many different kind of medicines, while their vulnerability to pharmaceutical products is increased. The objective of this study is to describe the medicine utilization pattern in people aged 65 years and older in Belgium, and to estimate the prevalence and the determinants of excessive polypharmacy. Methods Data were used from the Belgian Health Inte...

  7. An ultraluminous quasar with a twelve-billion-solar-mass black hole at redshift 6.30.

    Science.gov (United States)

    Wu, Xue-Bing; Wang, Feige; Fan, Xiaohui; Yi, Weimin; Zuo, Wenwen; Bian, Fuyan; Jiang, Linhua; McGreer, Ian D; Wang, Ran; Yang, Jinyi; Yang, Qian; Thompson, David; Beletsky, Yuri

    2015-02-26

    So far, roughly 40 quasars with redshifts greater than z = 6 have been discovered. Each quasar contains a black hole with a mass of about one billion solar masses (10(9) M Sun symbol). The existence of such black holes when the Universe was less than one billion years old presents substantial challenges to theories of the formation and growth of black holes and the coevolution of black holes and galaxies. Here we report the discovery of an ultraluminous quasar, SDSS J010013.02+280225.8, at redshift z = 6.30. It has an optical and near-infrared luminosity a few times greater than those of previously known z > 6 quasars. On the basis of the deep absorption trough on the blue side of the Lyman-α emission line in the spectrum, we estimate the proper size of the ionized proximity zone associated with the quasar to be about 26 million light years, larger than found with other z > 6.1 quasars with lower luminosities. We estimate (on the basis of a near-infrared spectrum) that the black hole has a mass of ∼1.2 × 10(10) M Sun symbol, which is consistent with the 1.3 × 10(10) M Sun symbol derived by assuming an Eddington-limited accretion rate. PMID:25719667

  8. An ultra-luminous quasar with a twelve-billion-solar-mass black hole at redshift 6.30

    CERN Document Server

    Wu, Xue-Bing; Fan, Xiaohui; Yi, Weimin; Zuo, Wenwen; Bian, Fuyan; Jiang, Linhua; McGreer, Ian D; Wang, Ran; Yang, Jinyi; Yang, Qian; Thompson, David; Beletsky, Yuri

    2015-01-01

    So far, roughly 40 quasars with redshifts greater than z=6 have been discovered. Each quasar contains a black hole with a mass of one billion solar masses ( $10^9 M_\\odot$). The existence of such black holes when the Universe was less than 1 billion years old presents substantial challenges to theories of the formation and growth of black holes and the coevolution of black holes and galaxies. Here we report the discovery of an ultra-luminous quasar, SDSS J010013.02+280225.8, at redshift z=6.30. It has an optical and near-infrared luminosity a few times greater than those of previously known z>6 quasars. On the basis of the deep absorption trough on the blue side of the Ly $\\alpha$ emission line in the spectrum, we estimate the proper size of the ionized proximity zone associated with the quasar to be 26 million light years, larger than found with other z>6.1 quasars with lower luminosities. We estimate (on the basis of a near-infrared spectrum) that the black hole has a mass of $\\sim 1.2 \\times 10^{10} M_\\odo...

  9. Impact of mandating a driving lesson for older drivers at license renewal in Japan.

    Science.gov (United States)

    Ichikawa, Masao; Nakahara, Shinji; Inada, Haruhiko

    2015-02-01

    In Japan, a driving lesson consisting of a lecture, a driver aptitude test, on-road driving assessment and a discussion session was added to the driving license renewal procedure for drivers aged 75 years or older in 1998 and for drivers aged 70 years or older in 2002. We investigated whether these additions contributed to a reduction in at-fault motor vehicle collisions (MVCs) by examining the trend of the at-fault MVC rates per licensed driver and the rate ratios of the older drivers relative to those aged 65-69 years for the years 1986-2011. All data were derived from nationwide traffic statistics. If the introduction of the lesson was effective in reducing at-fault MVCs of older drivers, the rate ratio should have declined, given that the lesson targeted only the older drivers. We found this was not the case, i.e., there was no declining trend in the at-fault MVC rate ratios of both drivers aged 75 years or older and drivers aged 70 years or older, relative to drivers aged 65-69 years, after the driving lesson at license renewal became mandatory for these older drivers. Therefore, the mandatory lesson for the older drivers at license renewal needs to be reconsidered. PMID:25460091

  10. 77 FR 15052 - Dataset Workshop-U.S. Billion Dollar Disasters Dataset (1980-2011): Assessing Dataset Strengths...

    Science.gov (United States)

    2012-03-14

    ... National Oceanic and Atmospheric Administration Dataset Workshop--U.S. Billion Dollar Disasters Dataset... Goals The workshop will focus on a review, discussion, and evaluation of NOAA's U.S. Billion Dollar... of the U.S. Billion Dollar Disasters Report; What additional data sources and/or new methods...

  11. Another Record Year for Academic Pork.

    Science.gov (United States)

    Brainard, Jeffrey

    2002-01-01

    Discusses how, fueled by the war on terrorism, Congress has awarded a record $1.8 billion in academic earmarks in the 2002 fiscal year. Profiles several recipient programs and includes a campus-by-campus list of projects. (EV)

  12. Recruiting older people at nutritional risk for clinical trials: what have we learned?

    OpenAIRE

    Piantadosi, Cynthia; Chapman, Ian M; Naganathan, Vasi; Hunter, Peter; Cameron, Ian D.; Visvanathan, Renuka

    2015-01-01

    Background The difficulty of recruiting older people to clinical trials is well described, but there is limited information about effective ways to screen and recruit older people into trials, and the reasons for their reluctance to enrol. This paper examines recruitment efforts for a community-based health intervention study that targeted older adults. Methods One year randomized control trial. Undernourished men and women, aged ≥ 65 years and living independently in the community were recru...

  13. Lived experiences and challenges of older surgical patients during hospitalization for cancer: An ethnographic fieldwork

    OpenAIRE

    Uhrenfeldt, Lisbeth; Høybye, Mette Terp

    2014-01-01

    This paper explores the lived experiences of older surgical patients’ (aged 74 years and older) experienced challenges during a brief admission to hospital. Age, gender, polypharmacy, and the severity of illness are also factors known to affect the hospitalization process. For an ethnographic study using participant observation and interviews, surgical cancer patients (n9, aged 74 years and older) were recruited during admission to a Danish teaching hospital. Using ethnographic strategies of ...

  14. In the eyes of older adults: Self-reported age and adjustment in African and European older adults

    OpenAIRE

    Sofia von Humbold; Isabel Leal; Filipa Pimenta; Georgeta Niculescu

    2013-01-01

    To explore older adults’ perceptions of subjective age and adjustment to ageing and to analyse the correlational structure of the pre-categories in our study: subjective age, indicators of adjustment to ageing and of personal age perception. An exploratory, descriptive mixed-methods design was utilised. A purposive sampling method was used to select 154 older adults aged between 75 and 99 years from three different nationalities. Semi-structured interviews were performed, addressing two core ...

  15. Fatigue and Depressive Symptoms in Older People

    DEFF Research Database (Denmark)

    Mänty, Minna; Rantanen, Taina; Era, Pertti; Avlund, Kirsten

    2014-01-01

    Fatigue is considered an important indicator of aging-related declines in health and functional abilities. Previous studies have indicated strong associations between fatigue and depressive symptoms among younger populations and in patient groups with specific diseases. However, it is not known how...... different measures of fatigue are associated with depressive symptoms among general older populations. The purpose of this study is to describe the prevalence of depressive symptoms among community-dwelling older adults reporting mobility-related or general feelings fatigue. The study population consisted...... of 75-year-old community-living individuals (n = 561). Both, mobility-related and general fatigue, were associated in a stepwise relationship with depressive symptoms: a higher level of fatigue was related to higher level of depressive symptoms. Especially major general fatigue was strongly...

  16. Dextropropoxyphene: safety and efficacy in older patients.

    Science.gov (United States)

    Goldstein, David J; Turk, Dennis C

    2005-01-01

    Dextropropoxyphene, alone or in combination with acetaminophen (paracetamol), is among the most frequently prescribed opioid analgesics in the elderly in the US despite the American Geriatric Society recommendation that its use should be restricted. However, this recommendation is based on expert opinion in an apparent absence of data. Accordingly, we conducted a literature search which identified nine studies that reported efficacy and safety data for dextropropoxyphene in predominantly older patients (> or = 55 years of age). These studies were evaluated to assess the efficacy and safety of dextropropoxyphene compared with other opioids and to evaluate whether safety and tolerability differed in older versus younger patients. The efficacy of dextropropoxyphene appeared to be similar to that of other analgesics, and its safety was comparable to that of other opioid analgesics. Although the adverse event profile suggests that elderly patients might have more frequent gastrointestinal and CNS complaints than younger patients treated with dextropropoxyphene, the frequency of reports appears similar to that of other opioids. The incidences of dizziness and somnolence were not significantly greater in older patients (1-2% and 0-21%, respectively) than in younger patients (8% and 13%, respectively). The absence of clinical studies directly addressing the safety and tolerability of dextropropoxyphene in elderly patients (>65 years of age) versus younger patients encumbers assessment of the validity of restricting its use in the elderly. Careful outcomes research is needed to assess the effectiveness and safety of dextropropoxyphene in older patients and to develop evidence-based risk/benefit prescribing criteria for use of this drug in this age group. PMID:15903354

  17. Life expectancy without depression increases among Brazilian older adults

    Science.gov (United States)

    Andrade, Flávia Cristina Drumond; Wu, Fan; Lebrão, Maria Lúcia; Duarte, Yeda Aparecida de Oliveira

    2016-01-01

    ABSTRACT OBJECTIVE To estimate life expectancy with and without depressive symptoms in older adults for the years 2000 and 2010. METHODS We evaluated individuals aged 60 years or older (n = 1,862 in 2000 and n = 1,280 in 2010), participants of the Saúde, Bem-Estar e Envelhecimento (SABE – Health, Wellbeing and Aging) study in in Sao Paulo, Southeastern Brazil. Depression was measured using the shorter version of the Geriatric Depression Scale (GDS-15); respondents scoring ≥ 6 were classified as having depression. Estimates of life expectancy with and without depression were obtained using the Sullivan method. RESULTS Data from 2000 indicate that 60-year-old men could expect to live, on average, 14.7 years without depression and 60-year-old women could expect to live 16.5 years without depression. By 2010, life expectancy without depression had increased to 16.7 years for men and 17.8 years for women. Expected length of life with depression differed by sex, with women expected to live more years with depression than men. CONCLUSIONS Between 2000 and 2010, life expectancy without depression in Sao Paulo increased. However, older adults in Brazil, especially older women, still face a serious burden of mental illness. PMID:27143612

  18. Gun Access and Safety Practices among Older Adults

    Directory of Open Access Journals (Sweden)

    Hillary D. Lum

    2016-01-01

    Full Text Available Background. Given high rates of gun ownership among older adults, geriatric providers can assess firearm safety practices using a “5 Ls” approach: Locked; Loaded; Little children; feeling Low; and Learned owner. This study describes gun access and the “5 Ls” among US older adults. Methods. Data on the “5 Ls” from the Second Injury Control and Risk Survey (ICARIS-2, a national telephone survey conducted by the Centers for Disease Control and Prevention, were analyzed. Weighted variables were used to generate national estimates regarding prevalence of gun ownership and associated gun safety among older adults (≥55 years. Results. Of 2939 older adults, 39% (95% CI 37%–42% reported ≥1 gun stored at home. Among those with guns at home, 21% (95% CI 18–24% stored guns loaded and unlocked; 9.2% (95% CI 6.6–12% had ≥1 child in household; 5.1% (95% CI 3.5–6.8% reported past-year suicidal ideation and 3.6% (95% CI 2.1–5.2% reported history of a suicide attempt; and 55% (95% CI 51–59% stated that ≥1 adult had attended firearm safety workshop. Conclusion. Some older adults may be at elevated risk of firearm injury because of storage practices, suicidal thoughts, or limited safety training. Future work should assess effective approaches to reduce the risk of gun-related injuries among older adults.

  19. Gun Access and Safety Practices among Older Adults.

    Science.gov (United States)

    Lum, Hillary D; Flaten, Hanna K; Betz, Marian E

    2016-01-01

    Background. Given high rates of gun ownership among older adults, geriatric providers can assess firearm safety practices using a "5 Ls" approach: Locked; Loaded; Little children; feeling Low; and Learned owner. This study describes gun access and the "5 Ls" among US older adults. Methods. Data on the "5 Ls" from the Second Injury Control and Risk Survey (ICARIS-2), a national telephone survey conducted by the Centers for Disease Control and Prevention, were analyzed. Weighted variables were used to generate national estimates regarding prevalence of gun ownership and associated gun safety among older adults (≥55 years). Results. Of 2939 older adults, 39% (95% CI 37%-42%) reported ≥1 gun stored at home. Among those with guns at home, 21% (95% CI 18-24%) stored guns loaded and unlocked; 9.2% (95% CI 6.6-12%) had ≥1 child in household; 5.1% (95% CI 3.5-6.8%) reported past-year suicidal ideation and 3.6% (95% CI 2.1-5.2%) reported history of a suicide attempt; and 55% (95% CI 51-59%) stated that ≥1 adult had attended firearm safety workshop. Conclusion. Some older adults may be at elevated risk of firearm injury because of storage practices, suicidal thoughts, or limited safety training. Future work should assess effective approaches to reduce the risk of gun-related injuries among older adults. PMID:26949391

  20. Tuberculosis among older adults – time to take notice

    Directory of Open Access Journals (Sweden)

    Joel Negin

    2015-03-01

    Full Text Available Knowledge that older people are vulnerable to develop tuberculosis is rarely considered in developing country settings. According to 2010 Global Burden of Disease estimates, the majority of tuberculosis-related deaths occurred among people older than 50; most in those aged 65 and above. Older people also contribute a large proportion of Disability-Adjusted Life Years (DALYs; 51% of tuberculosis DALYs occurred in patients aged 50 years and older in East Asia. Tuberculosis age distributions in Africa have been severely skewed by the human immunodeficiency virus (HIV epidemic, but emerging data suggest increasing disease burdens among older people. Older adults are more likely to develop extra-pulmonary and atypical forms of disease that are often harder to diagnose than conventional sputum smear-positive pulmonary tuberculosis. Their care is complicated by more frequent drug-related adverse events and increased co-morbidity, which may prove difficult to manage in regions where health resources are already constrained. Health systems will have to confront the challenge of an ageing global population and the integrated services required to address their health needs.

  1. CROSS SECTIONAL STUDY OF NUTRITIONAL STATUS IN OLDER HAN WOMEN.

    Science.gov (United States)

    Jun, Tao; Yuan, Zhong

    2016-01-01

    Abstract. Malnutrition is one of the most prevalent problems in older people, but there is little information about the nutritional status of the older women in China. Therefore, this study was conducted to investigate the nutritional status and clinically correlated factors for malnutrition in older Han women in China. In total, 2,556 hospital- and community-based Han women aged 60 years or older were recruited between May 2007 and December 2014. All women completed comprehensive geriatric assessment, and the Mini Nutritional Assessment Short Form (MNA-SF) was used to assess the nutritional status. The clinically corre- lated factors for malnutrition were also analyzed, including social factors, health status, and dietary behavior. The average age of these women was 75.9 ± 9.4 years, and 63.8% women lived in urban areas. Of the total respondents, 344 and 716 women were classified as malnutrition and at risk of malnutrition, respectively. Five factors were independently and positively correlated with poor nutrition, including chronic obstructive pulmonary disease (COPD), gastrointestinal disease, depression, cognitive impairment, and comorbidity (≥ 2). Three factors were independently and negatively correlated with poor nutrition, including economic status, meat intake, and fish intake. The older Han women with these five health problems should be given more attention with regards to their nutritional status. Improving economic status, eating more meat and fish were recommended for preventing poor nutrition in older women. PMID:27086430

  2. Gun Access and Safety Practices among Older Adults

    Science.gov (United States)

    Lum, Hillary D.; Flaten, Hanna K.; Betz, Marian E.

    2016-01-01

    Background. Given high rates of gun ownership among older adults, geriatric providers can assess firearm safety practices using a “5 Ls” approach: Locked; Loaded; Little children; feeling Low; and Learned owner. This study describes gun access and the “5 Ls” among US older adults. Methods. Data on the “5 Ls” from the Second Injury Control and Risk Survey (ICARIS-2), a national telephone survey conducted by the Centers for Disease Control and Prevention, were analyzed. Weighted variables were used to generate national estimates regarding prevalence of gun ownership and associated gun safety among older adults (≥55 years). Results. Of 2939 older adults, 39% (95% CI 37%–42%) reported ≥1 gun stored at home. Among those with guns at home, 21% (95% CI 18–24%) stored guns loaded and unlocked; 9.2% (95% CI 6.6–12%) had ≥1 child in household; 5.1% (95% CI 3.5–6.8%) reported past-year suicidal ideation and 3.6% (95% CI 2.1–5.2%) reported history of a suicide attempt; and 55% (95% CI 51–59%) stated that ≥1 adult had attended firearm safety workshop. Conclusion. Some older adults may be at elevated risk of firearm injury because of storage practices, suicidal thoughts, or limited safety training. Future work should assess effective approaches to reduce the risk of gun-related injuries among older adults. PMID:26949391

  3. Portuguese Older Gay Men: Pathways to Family Integrity

    Directory of Open Access Journals (Sweden)

    Filipa Daniela Marques

    2016-08-01

    Full Text Available Abstract Research in the field of older gay men remains scarce. This exploratory study examines older gay men's experiences in the construction of family integrity (versus disconnection and alienation. The family integrity approach is a developmental perspective that links ego integrity to a larger process of constructing meaning within the family system. The sample comprises ten participants (from 60 to 88 years old. A semi-structured interview was conducted and submitted to content analysis. The main findings suggest three experiences in older gay men's construction of family integrity: (i influence of homosexuality throughout life; (ii establishing a family of choice; (iii creating a legacy associated with homosexuality. Family integrity in older gay men seems to evolve from disclosure at a young age to making homosexuality a legacy in old age.

  4. The pharmacist's role in preventing medication errors in older adults.

    Science.gov (United States)

    Kasbekar, Rupal; Maples, Meghan; Bernacchi, Ann; Duong, Linh; Oramasionwu, Christine U

    2014-12-01

    Approximately 1.5 million medication errors occur each year in the United States. Older adults may be at increased risk for these errors as a result of a variety of contributing factors such as inappropriate medication use, polymorbidity, and complexities in managing dosage adjustments for geriatric patients. Pharmacists, as trained medication experts, are uniquely poised to lead efforts to prevent, detect, and resolve medications errors. As the American population continues to age, future pharmacists are likely to play an even greater role in promoting safe and effective medication use in older adults. In this paper, we highlight common settings for medication errors in older individuals, explore tools and solutions for error prevention, and outline the unique role that pharmacists have in preventing medication errors in older adults. PMID:25521659

  5. Predictors of long term mortality in older people with hip fracture

    DEFF Research Database (Denmark)

    Ariza-Vega, Patrocinio; Kristensen, Morten Tange; Martín-Martín, Lydia;

    2015-01-01

    OBJECTIVE: To determine one year mortality and predisposing factors in older people who had surgery after a hip fracture. DESIGN: Prospective cohort study. SETTING: Public acute hospital, trauma service. PARTICIPANTS: A total of 281 patients, 65 years or older, admitted with a hip fracture within...

  6. Learning (Not) to Talk about Race: When Older Children Underperform in Social Categorization

    Science.gov (United States)

    Apfelbaum, Evan P.; Pauker, Kristin; Ambady, Nalini; Sommers, Samuel R.; Norton, Michael I.

    2008-01-01

    The present research identifies an anomaly in sociocognitive development, whereby younger children (8 and 9 years) outperform their older counterparts (10 and 11 years) in a basic categorization task in which the acknowledgment of racial difference facilitates performance. Though older children exhibit superior performance on a race-neutral…

  7. Randomized Trial of Social Rehabilitation and Integrated Health Care for Older People with Severe Mental Illness

    Science.gov (United States)

    Mueser, Kim T.; Pratt, Sarah I.; Bartels, Stephen J.; Swain, Karin; Forester, Brent; Cather, Corinne; Feldman, James

    2010-01-01

    Objective: The Helping Older People Experience Success (HOPES) program was developed to improve psychosocial functioning and reduce long-term medical burden in older people with severe mental illness (SMI) living in the community. HOPES includes 1 year of intensive skills training and health management, followed by a 1-year maintenance phase.…

  8. Falls and Drugs in the Older Population: medical and societal consequences

    NARCIS (Netherlands)

    K.A. Hartholt (Klaas)

    2011-01-01

    textabstractFalls represent a major public health problem among older persons in western countries, since approximately a third of all persons aged 65 years and older experience at least one fall per year. This thesis provides insights in the epidemiology, injury patterns, healthcare costs,

  9. Cancer: Unique to Older Adults

    Science.gov (United States)

    ... Tuesday, August 11, 2015 Join our e-newsletter! Aging & Health A to Z Cancer Unique to Older ... effect of your narcotic medications. These include: antidepressants anti-epileptic (anti-seizure) drugs steroids. Radiation for pain ...

  10. Older Adults and Smell Loss

    Medline Plus

    Full Text Available ... be very devastating because all of a sudden one of the main senses that they get pleasure ... they have a problem with smell. Dr. Cowart: One of the most dangerous things for older people ...

  11. Diabetes: Unique to Older Adults

    Science.gov (United States)

    ... Glaucoma High Blood Pressure Managing Multiple Health Problems Pain Management Peripheral ... section provides information to help older adults and their caregivers consider their disease or condition in conjunction with ...

  12. Cognitive Interventions for Older Diabetics.

    Science.gov (United States)

    Black, Sheila; Scogin, Forrest

    1998-01-01

    Older diabetic adults should receive memory training to improve their compliance with medication taking. The intervention should include comprehensible medical instructions, assistance with remembering the nutritional values of food, and higher order skills for disease management. (SK)

  13. Alcohol Use and Older Adults

    Science.gov (United States)

    ... version of this page please turn Javascript on. Alcohol Use and Older Adults Alcohol and Aging Adults of any age can have ... Escape (Esc) button on your keyboard.) What Is Alcohol? Alcohol, also known as ethanol, is a chemical ...

  14. Older Adults and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... JSR 286) Actions ${title} Loading... Older Adults and Food Safety An adage states, "With age, comes wisdom." Hopefully ...

  15. Heat Stress in Older Adults

    Science.gov (United States)

    ... Landslides Tornadoes Tsunamis Volcanoes Wildfires Winter Weather Heat Stress in Older Adults Recommend on Facebook Tweet Share ... What You Can Do for Someone With Heat Stress If you see any signs of severe heat ...

  16. Biomass as Feedstock for a Bioenergy and Bioproducts Industry: The Technical Feasibility of a Billion-Ton Annual Supply, April 2005

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-04-01

    The purpose of this report is to determine whether the land resources of the United States are capable of producing a sustainable supply of biomass sufficient to displace 30 percent or more of the country’s present petroleum consumption – the goal set by the Biomass R&D Technical Advisory Committee in their vision for biomass technologies. Accomplishing this goal would require approximately 1 billion dry tons of biomass feedstock per year.

  17. Meeting the Needs of Older Students in Higher Education

    Science.gov (United States)

    Caruth, Gail D.

    2014-01-01

    The number of students 25 years of age and older enrolled in higher education has been escalating over the past 50 years. What is higher education doing to prepare for this growth? With adults constituting almost half of today's student body, it is important to consider whether the academy is prepared to serve this society of adult learners.…

  18. Sexuality in Nigerian older adults

    OpenAIRE

    Olatayo, Adeoti Adekunle; Kubwa, Ojo Osaze; Adekunle, Ajayi Ebenezer

    2015-01-01

    Introduction Oftentimes the older adults are assumed to be asexual as few studies explore into the sexuality of this age group worldwide and even in Nigeria. It is an important aspect of quality of life which is often neglected by people in this age group, attending physicians and the society as a whole. The study was aimed at determining the perception of older adults about sexuality, identify the factors that could militate against sexuality and fill any void in information in this regard. ...

  19. Appropriate prescribing for older people

    OpenAIRE

    Drenth - van Maanen, A.C.

    2013-01-01

    Appropriate prescribing is the result of pharmacotherapeutic decision-making to maximise the net health benefit of treatment, given the resources available. Several risk factors for inappropriate prescribing in older people have been identified, such as polypharmacy, impaired renal function, and frequent transfers between healthcare settings. The objectives of the studies described in this thesis were to describe the frequency and nature of risk factors for inappropriate prescribing in older ...

  20. Cardiac Rehabilitation in Older Adults.

    Science.gov (United States)

    Schopfer, David W; Forman, Daniel E

    2016-09-01

    The biology of aging and the pathophysiology of cardiovascular disease (CVD) overlap, with the effect that CVD is endemic in the growing population of older adults. Moreover, CVD in older adults is usually complicated by age-related complexities, including multimorbidity, polypharmacy, frailty, and other intricacies that add to the risks of ambiguous symptoms, deconditioning, iatrogenesis, falls, disability, and other challenges. Cardiac rehabilitation (CR) is a comprehensive lifestyle program that can have particular benefit for older patients with cardiovascular conditions. Although CR was originally designed primarily as an exercise training program for younger adults after a myocardial infarction or coronary artery bypass surgery, it has evolved as a comprehensive lifestyle program (promoting physical activity as well as education, diet, risk reduction, and adherence) for a broader range of CVD (coronary heart disease, heart failure, and valvular heart disease). It provides a valuable opportunity to address and moderate many of the challenges pertinent for the large and growing population of older adults with CVD. Cardiac rehabilitation promotes physical function (cardiorespiratory fitness as well as strength and balance) that helps overcome disease and deconditioning as well as related vulnerabilities such as disability, frailty, and falls. Similarly, CR facilitates education, monitoring, and guidance to reduce iatrogenesis and promote adherence. Furthermore, CR fosters cognition, socialization, and independence in older patients. Yet despite all its conceptual benefits, CR is significantly underused in older populations. This review discusses benefits and the paradoxical underuse of CR, as well as evolving models of care that may achieve greater application and efficacy. PMID:27297002