WorldWideScience

Sample records for bilayers interbilayer bridges

  1. Salt-bridge-supported bilayer lipid membrane biosensor for determination of anticancer drug cyclophosphamide

    Science.gov (United States)

    Zhang, Yanli; Wang, Tao; Zhang, Chunxu; Shen, Hanxi; Chao, Fuhuan

    2001-09-01

    A novel biosensor for assaying anticancer drug cyclophosphamide was constructed with salt-bridge supported bilayer lipid membrane modified with tetraphenylborate- cyclophosphamide complex. The modification was achieved by the introduction of the complex into the membrane forming solution. The biosensor show a linear response to the drug over the concentration range 8.96 X 10-6 mol L-1. The effects of coexistent substances and pH on assay were evaluated. The results show that the distinguish merits of this kind of biosensor is the excellently biological compatibility and no need of mediator for ions exchange. It also shows good selectivity and sensitivity for cyclophosphamide assay.

  2. X-Ray Kinematography of Temperature-Jump Relaxation Probes the Elastic Properties of Fluid Bilayers

    OpenAIRE

    Pabst, Georg; Rappolt, Michael; Amenitsch, Heinz; Bernstorff, Sigrid; Laggner, Peter

    2000-01-01

    The response kinetics of liquid crystalline phosphatidylcholine bilayer stacks to rapid, IR-laser induced temperature jumps has been studied by millisecond time-resolved x-ray diffraction. The system reacts on the fast temperature change by a discrete bilayer compression normal to its surface and a lateral bilayer expansion. Since water cannot diffuse from the excess phase into the interbilayer water region within the 2 ms duration of the laser pulse, the water layer has to follow the bilayer...

  3. X-Ray Kinematography of Temperature-Jump Relaxation Probes the Elastic Properties of Fluid Bilayers

    CERN Document Server

    Pabst, G; Amenitsch, H; Bernstorff, S; Laggner, P; Pabst, Georg; Rappolt, Michael; Amenitsch, Heinz; Bernstorff, Sigrid; Laggner, Peter

    2000-01-01

    The response kinetics of liquid crystalline phosphatidylcholine bilayerstacks to rapid, IR-laser induced temperature jumps has been studied bymillisecond time-resolved x-ray diffraction. The system reacts on the fasttemperature change by a discrete bilayer compression normal to its surface anda lateral bilayer expansion. Since water cannot diffuse from the excess phaseinto the interbilayer water region within the 2 ms duration of the laser pulse,the water layer has to follow the bilayer expansion, by an anomalous thinning.Structural analysis of a 20 ms diffraction pattern from the intermediate phaseindicates that the bilayer thickness remains within the limits of isothermalequilibrium values. Both, the intermediate structure and its relaxation intothe original equilibrium L_(alpha)-phase, depend on the visco-elasticproperties of the bilayer/water system. We present an analysis of therelaxation process by an overdamped one-dimensional oscillation model revealingthe concepts of Hooke's law for phospholipid bila...

  4. Effect of Solvent Dielectric Constant on the Formation of Large Flat Bilayer Stacks in a Lecithin/Hexadecanol Hydrogel.

    Science.gov (United States)

    Nakagawa, Yasuharu; Nakazawa, Hiromitsu; Kato, Satoru

    2016-07-12

    We investigated the effect of dielectric properties of the aqueous medium on the novel type of hydrogel composed of a crude lecithin mixture (PC70) and hexadecanol (HD), in which charged sheet-like bilayers are kept far apart due to interbilayer repulsive interaction. We used dipropylene glycol (DPG) as a modifier of the dielectric properties and examined its effect on the hydrogel by synchrotron X-ray diffraction, differential scanning calorimetry (DSC), polarized optical microscopy, and freeze-fracture electron microscopy. We found that at a DPG weight fraction in the aqueous medium WDPG ≈ 0.4, the bilayer organization is transformed into unusually large flat bilayer stacks with a regular lamellar spacing of 6.25 nm and consequently disintegration of the hydrogel takes place. Semiquantitative calculation of the interbilayer interaction energy based on the Deyaguin-Landau-Verwey-Overbeek (DLVO) theory suggested that the reduction of the aqueous medium dielectric constant ε by DPG may lower the energy barrier preventing flat bilayers from coming closer together. We inferred that the size of the bilayer sheet increases because the reduction of ε promotes protonation of acidic lipids that work as edge-capping molecules. PMID:27322136

  5. Structural Effects of Small Molecules on Phospholipid Bilayers Investigated by Molecular Simulations

    CERN Document Server

    Lee, B W; Sum, A K; Vattulainen, I; Patra, M; Karttunen, M; Lee, Bryan W; Faller, Roland; Sum, Amadeu K; Vattulainen, Ilpo; Patra, Michael; Karttunen, Mikko

    2004-01-01

    We summarize and compare recent Molecular Dynamics simulations on the interactions of dipalmitoylphosphatidylcholine (DPPC) bilayers in the liquid crystalline phase with a number of small molecules including trehalose, a disaccharide of glucose, alcohols, and dimethylsulfoxide (DMSO). The sugar molecules tend to stabilize the structure of the bilayer as they bridge adjacent lipid headgroups. They do not strongly change the structure of the bilayer. Alcohols and DMSO destabilize the bilayer as they increase its area per molecule in the bilayer plane and decrease the order parameter. Alcohols have a stronger detrimental effect than DMSO. The observables which we compare are the area per molecule in the plane of the bilayer, the membrane thickness, and the NMR order parameter of DPPC hydrocarbon tails. The area per molecule and the order parameter are very well correlated whereas the bilayer thickness is not necessarily correlated with them.

  6. A Molecular Dynamics Study of the Structural and Dynamical Properties of Putative Arsenic Substituted Lipid Bilayers

    Directory of Open Access Journals (Sweden)

    Ratna Juwita

    2013-04-01

    Full Text Available Cell membranes are composed mainly of phospholipids which are in turn, composed of five major chemical elements: carbon, hydrogen, nitrogen, oxygen, and phosphorus. Recent studies have suggested the possibility of sustaining life if the phosphorus is substituted by arsenic. Although this issue is still controversial, it is of interest to investigate the properties of arsenated-lipid bilayers to evaluate this possibility. In this study, we simulated arsenated-lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-arsenocholine (POAC, lipid bilayers using all-atom molecular dynamics to understand basic structural and dynamical properties, in particular, the differences from analogous 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, (POPC lipid bilayers. Our simulations showed that POAC lipid bilayers have distinct structural and dynamical properties from those of native POPC lipid bilayers. Relative to POPC lipid bilayers, POAC lipid bilayers have a more compact structure with smaller lateral areas and greater order. The compact structure of POAC lipid bilayers is due to the fact that more inter-lipid salt bridges are formed with arsenate-choline compared to the phosphate-choline of POPC lipid bilayers. These inter-lipid salt bridges bind POAC lipids together and also slow down the head group rotation and lateral diffusion of POAC lipids. Thus, it would be anticipated that POAC and POPC lipid bilayers would have different biological implications.

  7. Bridge? What's a Bridge?

    Science.gov (United States)

    Gutsche, George

    1996-01-01

    Considers the metaphor of the "bridge" as it applies to Russian-language courses at the university level. The article examines broader curricular issues of technology, innovation, and outside pressures on language teaching. (22 references) (CK)

  8. Railroad Bridges

    Data.gov (United States)

    Department of Homeland Security — Bridges-Rail in the United States According to The National Bridge Inspection Standards published in the Code of Federal Regulations (23 CFR 650.3), a bridge isA...

  9. Compressibility of bilayer graphene

    OpenAIRE

    Borghi, Giovanni; Polini, Marco; Asgari, Reza; MacDonald, A. H.

    2010-01-01

    Bilayer graphene is a recently isolated and intriguing class of many-body systems with massive chiral quasiparticles. We present theoretical results for the electronic compressibility of bilayer graphene that are based on a four-band continuum band structure model combined with a random phase approximation treatment of electronic correlations. We find that the compressibility is strongly suppressed by electron-electron interactions at low carrier densities. Correlations do not lead to any qua...

  10. Myocardial Bridging.

    Science.gov (United States)

    Yuan, Shi-Min

    2016-02-01

    Myocardial bridging is rare. Myocardial bridges are most commonly localized in the middle segment of the left anterior descending coronary artery. The anatomic features of the bridges vary significantly. Alterations of the endothelial morphology and the vasoactive agents impact on the progression of atherosclerosis of myocardial bridging. Patients may present with chest pain, myocardial infarction, arrhythmia and even sudden death. Patients who respond poorly to the medical treatment with β-blockers warrant a surgical intervention. Myotomy is a preferred surgical procedure for the symptomatic patients. Coronary stent deployment has been in limited use due to the unsatisfactory long-term results. PMID:27074276

  11. Myocardial Bridging

    Directory of Open Access Journals (Sweden)

    Shi-Min Yuan

    2016-02-01

    Full Text Available Abstract Myocardial bridging is rare. Myocardial bridges are most commonly localized in the middle segment of the left anterior descending coronary artery. The anatomic features of the bridges vary significantly. Alterations of the endothelial morphology and the vasoactive agents impact on the progression of atherosclerosis of myocardial bridging. Patients may present with chest pain, myocardial infarction, arrhythmia and even sudden death. Patients who respond poorly to the medical treatment with β-blockers warrant a surgical intervention. Myotomy is a preferred surgical procedure for the symptomatic patients. Coronary stent deployment has been in limited use due to the unsatisfactory long-term results.

  12. Phospholipid bilayers are viscoelastic

    OpenAIRE

    Harland, Christopher W.; Bradley, Miranda J.; Parthasarathy, Raghuveer

    2010-01-01

    Lipid bilayers provide the structural framework for cellular membranes, and their character as two-dimensional fluids enables the mobility of membrane macromolecules. Though the existence of membrane fluidity is well established, the nature of this fluidity remains poorly characterized. Three-dimensional fluids as diverse as chocolates and cytoskeletal networks show a rich variety of Newtonian and non-Newtonian dynamics that have been illuminated by contemporary rheological techniques. Applyi...

  13. Irradiated bilayer graphene

    OpenAIRE

    Abergel, D. S. L.; Chakraborty, Tapash

    2010-01-01

    We describe the gated bilayer graphene system when it is subjected to intense terahertz frequency electromagnetic radiation. We examine the electron band structure and density of states via exact diagonalization methods within Floquet theory. We find that dynamical states are induced which lead to modification of the band structure. We first examine the situation where there is no external magnetic field. In the unbiased case, dynamical gaps appear in the spectrum which manifest as dips in th...

  14. Twisted Bilayer Graphene Superlattices

    OpenAIRE

    Wang, Yanan; Su, Zhihua; Wu, Wei; Nie, Shu; Xie, Nan; Gong, Huiqi; Guo, Yang; Lee, Joon Hwan; Xing, Sirui; Lu, Xiaoxiang; Wang, Haiyan; Lu, Xinghua; McCarty, Kevin; Pei, Shin- shem; Robles-Hernandez, Francisco

    2013-01-01

    Twisted bilayer graphene (tBLG) provides us with a large rotational freedom to explore new physics and novel device applications, but many of its basic properties remain unresolved. Here we report the synthesis and systematic Raman study of tBLG. Chemical vapor deposition was used to synthesize hexagon- shaped tBLG with a rotation angle that can be conveniently determined by relative edge misalignment. Superlattice structures are revealed by the observation of two distinctive Raman features: ...

  15. Bridge Management Systems

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper bridge management systems are discussed with special emphasis on management systems for reinforced concrete bridges. Management systems for prestressed concrete bridges, steel bridges, or composite bridges can be developed in a similar way....

  16. Programmevaluierung Bridge

    OpenAIRE

    Warta, Katharina; Good, Barbara; Geyer, Anton

    2009-01-01

    BRIDGE is an initiative funded by the Ministry for Transport, Innovation and Technology (BMVIT) that aims to close the “funding gap” between basic and applied research in stand-alone projects with the primary objective of jointly developing the potential of basic and applied research. BRIDGE acts as an  umbrella structure under which the Austrian Science Fund (FWF) and the  Austrian Research Promotion Agency (FFG) coordinate two thematically open funding programmes: The ...

  17. National Bridge Inventory (NBI) Bridges

    Data.gov (United States)

    Department of Homeland Security — The NBI is a collection of information (database) describing the more than 600,000 of the Nation's bridges located on public roads, including Interstate Highways,...

  18. Bursting Bubbles and Bilayers

    Directory of Open Access Journals (Sweden)

    Steven P. Wrenn, Stephen M. Dicker, Eleanor F. Small, Nily R. Dan, Michał Mleczko, Georg Schmitz, Peter A. Lewin

    2012-01-01

    Full Text Available This paper discusses various interactions between ultrasound, phospholipid monolayer-coated gas bubbles, phospholipid bilayer vesicles, and cells. The paper begins with a review of microbubble physics models, developed to describe microbubble dynamic behavior in the presence of ultrasound, and follows this with a discussion of how such models can be used to predict inertial cavitation profiles. Predicted sensitivities of inertial cavitation to changes in the values of membrane properties, including surface tension, surface dilatational viscosity, and area expansion modulus, indicate that area expansion modulus exerts the greatest relative influence on inertial cavitation. Accordingly, the theoretical dependence of area expansion modulus on chemical composition - in particular, poly (ethylene glyclol (PEG - is reviewed, and predictions of inertial cavitation for different PEG molecular weights and compositions are compared with experiment. Noteworthy is the predicted dependence, or lack thereof, of inertial cavitation on PEG molecular weight and mole fraction. Specifically, inertial cavitation is predicted to be independent of PEG molecular weight and mole fraction in the so-called mushroom regime. In the “brush” regime, however, inertial cavitation is predicted to increase with PEG mole fraction but to decrease (to the inverse 3/5 power with PEG molecular weight. While excellent agreement between experiment and theory can be achieved, it is shown that the calculated inertial cavitation profiles depend strongly on the criterion used to predict inertial cavitation. This is followed by a discussion of nesting microbubbles inside the aqueous core of microcapsules and how this significantly increases the inertial cavitation threshold. Nesting thus offers a means for avoiding unwanted inertial cavitation and cell death during imaging and other applications such as sonoporation. A review of putative sonoporation mechanisms is then presented

  19. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...... in the Media”, “Audience Interactivity and Participation”, “The Role of Media and ICT Use for Evolving Social Relationships” and “Audience Transformations and Social Integration”. Building Bridges is the result of an ongoing dialogue between the Action and non-academic stakeholders in the field of audience...

  20. Cholesterol's location in lipid bilayers.

    Science.gov (United States)

    Marquardt, Drew; Kučerka, Norbert; Wassall, Stephen R; Harroun, Thad A; Katsaras, John

    2016-09-01

    It is well known that cholesterol modifies the physical properties of lipid bilayers. For example, the much studied liquid-ordered Lo phase contains rapidly diffusing lipids with their acyl chains in the all trans configuration, similar to gel phase bilayers. Moreover, the Lo phase is commonly associated with cholesterol-enriched lipid rafts, which are thought to serve as platforms for signaling proteins in the plasma membrane. Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown - at least in some bilayers - to align differently from its canonical upright orientation, where its hydroxyl group is in the vicinity of the lipid-water interface. In this article we review recent works describing cholesterol's location in different model membrane systems with emphasis on results obtained from scattering, spectroscopic and molecular dynamics studies. PMID:27056099

  1. Stone bridges

    Czech Academy of Sciences Publication Activity Database

    Drdácký, Miloš; Slížková, Zuzana

    Prague : Institute of theoretical and applied mechanics AS CR, v.v.i, 2011 - (Drdácký, M.; Binda, L.; Hennen, I.; Kőpp, C.; Lanza, L.), s. 122-129 ISBN 978-80-86246-37-6 Grant ostatní: evropská komise(XE) CHEF-SSPI-044251 Institutional research plan: CEZ:AV0Z20710524 Keywords : flood * stone bridge * cultural heritage Subject RIV: AL - Art, Architecture, Cultural Heritage

  2. Computer Simulations of Lipid Bilayers and Proteins

    DEFF Research Database (Denmark)

    Sonne, Jacob

    2006-01-01

    The importance of computer simulations in lipid bilayer research has become more prominent for the last couple of decades and as computers get even faster, simulations will play an increasingly important part of understanding the processes that take place in and across cell membranes. This thesis...... entitled Computer simulations of lipid bilayers and proteins describes two molecular dynamics (MD) simulation studies of pure lipid bilayers as well as a study of a transmembrane protein embedded in a lipid bilayer matrix. Below follows a brief overview of the thesis. Chapter 1. This chapter is a short......, Pressure profile calculations in lipid bilayers: A lipid bilayer is merely $\\sim$5~nm thick, but the lateral pressure (parallel to the bilayer plane) varies several hundred bar on this short distance (normal to the bilayer). These variations in the lateral pressure are commonly referred to as the pressure...

  3. Electromechanical Oscillations in Bilayer Graphene

    OpenAIRE

    Benameur, Muhammed M.; Gargiulo, Fernando; Manzeli, Sajedeh; Autès, Gabriel; Tosun, Mahmut; Yazyev, Oleg V.; Kis, Andras

    2015-01-01

    Nanoelectromechanical systems constitute a class of devices lying at the interface between fundamental research and technological applications. Realizing nanoelectromechanical devices based on novel materials such as graphene allows studying their mechanical and electromechanical characteristics at the nanoscale and addressing fundamental questions such as electron–phonon interaction and bandgap engineering. In this work, we realize electromechanical devices using single and bilayer graphene ...

  4. Bilayer Effects of Antimalarial Compounds.

    Directory of Open Access Journals (Sweden)

    Nicole B Ramsey

    Full Text Available Because of the perpetual development of resistance to current therapies for malaria, the Medicines for Malaria Venture developed the Malaria Box to facilitate the drug development process. We tested the 80 most potent compounds from the box for bilayer-mediated effects on membrane protein conformational changes (a measure of likely toxicity in a gramicidin-based stopped flow fluorescence assay. Among the Malaria Box compounds tested, four compounds altered membrane properties (p< 0.05; MMV007384 stood out as a potent bilayer-perturbing compound that is toxic in many cell-based assays, suggesting that testing for membrane perturbation could help identify toxic compounds. In any case, MMV007384 should be approached with caution, if at all.

  5. Excitonic condensation in bilayer systems

    Science.gov (United States)

    Su, Jung-Jung

    Among the many examples of Bose condensation considered in physics, electron-hole-pair (exciton) condensation has maintained special interest because it has been difficult to realize experimentally, and because of controversy about condensate properties. In this thesis, we studied the various aspects of spontaneous symmetry broken state of exciton in bilayer using mean field theory. We calculated the photoluminescence of excitonic condensation created by laser. We developed a one-dimensional toy model of excitonic supercurrent using mean field theory plus non-equilibrium Green's function (NEGF) which give qualitatively consistent results with experiments. We proposed graphene bilayer as a novel system for excitonic condensation to occur and estimate it to exist even at temperature as high as room temperature.

  6. Cable Supported Bridges

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    Cable supported bridges in the form of suspension bridges and cable-stayed bridges are distinguished by their ability to overcome large spans.The book concentrates on the synthesis of cable supported bridges, covering both design and construction aspects. The analytical part covers simple methods...

  7. Reversibly formed bilayer vesicles: Energetics and polydispersity

    DEFF Research Database (Denmark)

    Bergstöm, M.

    Model calculations based on the multiple equilibrium approach indicate that the spontaneous formation of geometrically closed bilayer vesicles is geared primarily by the bilayer tension which in turn is largely determined by the work of bending the bilayer into a spherical vesicle. and a statisti......Model calculations based on the multiple equilibrium approach indicate that the spontaneous formation of geometrically closed bilayer vesicles is geared primarily by the bilayer tension which in turn is largely determined by the work of bending the bilayer into a spherical vesicle. and a...... orders of magnitude larger than where the local free energy minima of the equilibrium vesicle actually occur. Moreover, according to our analysis, the relative width of a vesicle size distribution, sigma(R)/R-max, is generally at full equilibrium equal to 0.283, independently of the energetic vesicle...

  8. Reversibly formed bilayer vesicles: Energetics and polydispersity

    DEFF Research Database (Denmark)

    Bergstöm, M.

    1997-01-01

    statistical-mechanical factor that accounts for the fluctuations in composition, chain packing density and shape. We demonstrate that the free energy required to form a spherical vesicle is made up of two main contributions: the (size-independent) work of bending the constituent monolayers and the work of......Model calculations based on the multiple equilibrium approach indicate that the spontaneous formation of geometrically closed bilayer vesicles is geared primarily by the bilayer tension which in turn is largely determined by the work of bending the bilayer into a spherical vesicle. and a...... stretching the bilayer that is determined by the planar bilayer tension. A previously undiscovered contribution to the work of bending a vesicle bilayer, originating from geometrical packing constraints, is presented. On this basis we obtain vesicle size distributions with maxima located at radii several...

  9. Fragmented state of lipid bilayers in water

    DEFF Research Database (Denmark)

    Helfrich, W.; Thimmel, J.; Klösgen, Beate Maria

    1999-01-01

    The bilayers of some typical biological membrane lipids such as PC and DGDG disintegrate in a large excess of water to form an optically invisible dispersive bilayer phase. `Dark bodies' can be reversibly precipitated from it by raising the temperature. The dispersive phase probably consists of...... `knotted sticks', i.e. very thin nodular tubes of bilayer. After reviewing pertinent experimental and theoretical work we report on the discovery of a lower consolute point near room temperature in DGDG/water systems. Its existence shows that the dispersive phase and the dark bodies belong to the same...... fragmented (or nodular) bilayer state, representing its expanded and condensed phases, respectively, above the critical temperature....

  10. Superdiffusion in supported lipid bilayers

    CERN Document Server

    Campagnola, Grace; Schroder, Bryce W; Peersen, Olve B; Krapf, Diego

    2015-01-01

    We study the diffusion of membrane-targeting C2 domains using single-molecule tracking in supported lipid bilayers. The ensemble-averaged mean square displacement (MSD) exhibits superdiffusive behavior. However, the time-averaged MSD of individual trajectories is found to be linear with respect to lag time, as in Brownian diffusion. These observations are explained in terms of bulk excursions that introduce jumps with a heavy-tail distribution. Our experimental results are shown to agree with analytical models of bulk-mediated diffusion and with numerical simulations.

  11. Annular bilayer magnetoelectric composites: theoretical analysis.

    Science.gov (United States)

    Guo, Mingsen; Dong, Shuxiang

    2010-01-01

    The laminated bilayer magnetoelectric (ME) composites consist of magnetostrictive and piezoelectric layers are known to have giant ME coefficient due to the high coupling efficiency in bending mode. In our previous report, the bar-shaped bilayer composite has been investigated by using a magnetoelectric-coupling equivalent circuit. Here, we propose an annular bilayer ME composite, which consists of magnetostrictive and piezoelectric rings. This composite has a much lower resonance frequency of bending mode compared with its radial mode. In addition, the annular bilayer ME composite is expected to respond to vortex magnetic field as well as unidirectional magnetic field. In this paper, we investigate the annular bilayer ME composite by using impedance-matrix method and predict the ME coefficients as a function of geometric parameters of the composites. PMID:20178914

  12. "Nanocrystal bilayer for tandem catalysis"

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Yusuke; Tsung, Chia Kuang; Huang, Wenyu; Huo, Ziyang; E.Habas, Susan E; Soejima, Tetsuro; Aliaga, Cesar E; Samorjai, Gabor A; Yang, Peidong

    2011-01-24

    Supported catalysts are widely used in industry and can be optimized by tuning the composition and interface of the metal nanoparticles and oxide supports. Rational design of metal-metal oxide interfaces in nanostructured catalysts is critical to achieve better reaction activities and selectivities. We introduce here a new class of nanocrystal tandem catalysts that have multiple metal-metal oxide interfaces for the catalysis of sequential reactions. We utilized a nanocrystal bilayer structure formed by assembling platinum and cerium oxide nanocube monolayers of less than 10 nm on a silica substrate. The two distinct metal-metal oxide interfaces, CeO2-Pt and Pt-SiO2, can be used to catalyse two distinct sequential reactions. The CeO2-Pt interface catalysed methanol decomposition to produce CO and H2, which were subsequently used for ethylene hydroformylation catalysed by the nearby Pt-SiO2 interface. Consequently, propanal was produced selectively from methanol and ethylene on the nanocrystal bilayer tandem catalyst. This new concept of nanocrystal tandem catalysis represents a powerful approach towards designing high-performance, multifunctional nanostructured catalysts

  13. Fusion and fission of fluid amphiphilic bilayers.

    Science.gov (United States)

    Gotter, Martin; Strey, Reinhard; Olsson, Ulf; Wennerström, Håkan

    2005-01-01

    The system water-oil (n-decane)-nonionic surfactant (C12E5) forms bilayer phases in a large concentration region, but, for a given oil-to-surfactant ratio, only in a narrow temperature range. In addition to the anisotropic lamellar phase (Lalpha) there is also, at slightly higher temperature, a sponge or L3-phase where the bilayers build up an isotropic structure extending macroscopically in three dimensions. In this phase the bilayer mid-surface has a mean curvature close to zero and a negative Euler characteristic. In this paper we study how the bilayers in the lamellar and the sponge phase respond dynamically to sudden temperature changes. The monolayer spontaneous curvature depends sensitively on temperature and a change of temperature thus provides a driving force for a change in bilayer topology. The equilibration therefore involves kinetic steps of fusion/fission of bilayers. Such dynamic processes have previously been monitored by temperature jump experiments using light scattering in the sponge phase. These experiments revealed an extraordinarily strong dependence of the relaxation time on the bilayer volume fraction phi. At phi magnetic resonance (2H-NMR) appear feasible. We here report on the first experiments concerned with the dynamics of the macroscopic phase transition sponge-lamellae by 2H-NMR. We find that the sponge-to-lamellae transition occurs through a nucleation process followed by domain growth involving bilayer fission at domain boundaries. In contrast, the lamellae-to-sponge transformation apparently occurs through a succession of uncorrelated bilayer fusion events. PMID:15715316

  14. Berry phase transition in twisted bilayer graphene

    Science.gov (United States)

    Rode, Johannes C.; Smirnov, Dmitri; Schmidt, Hennrik; Haug, Rolf J.

    2016-09-01

    The electronic dispersion of a graphene bilayer is highly dependent on rotational mismatch between layers and can be further manipulated by electrical gating. This allows for an unprecedented control over electronic properties and opens up the possibility of flexible band structure engineering. Here we present novel magnetotransport data in a twisted bilayer, crossing the energetic border between decoupled monolayers and coupled bilayer. In addition a transition in Berry phase between π and 2π is observed at intermediate magnetic fields. Analysis of Fermi velocities and gate induced charge carrier densities suggests an important role of strong layer asymmetry for the observed phenomena.

  15. Texture of lipid bilayer domains

    DEFF Research Database (Denmark)

    Jensen, Uffe Bernchou; Brewer, Jonathan R.; Midtiby, Henrik Skov; Ipsen, John Hjort; Bagatolli, Luis; Simonsen, Adam Cohen

    2009-01-01

    We investigate the texture of gel (g) domains in binary lipid membranes composed of the phospholipids DPPC and DOPC. Lateral organization of lipid bilayer membranes is a topic of fundamental and biological importance. Whereas questions related to size and composition of fluid membrane domain are...... chains. By imaging the intensity variations as a function of the polarization angle, we map the lateral variations of the lipid tilt within domains. Results reveal that gel domains are composed of subdomains with different lipid tilt directions. We have applied a Fourier decomposition method as a...... which correlates with the phase state of the membrane. This is quantified by the generalized polarization (GP) function, and we demonstrate that a GP analysis can be performed on supported membranes. The results show that although the gel domains have heterogeneous texture, the membrane phase state does...

  16. Spin dynamics of bilayer manganites

    Indian Academy of Sciences (India)

    Tapan Chatterji

    2004-07-01

    The results of inelastic and quasi-elastic neutron scattering investigations on the 40% hole-doped quasi-2D bilayer manganites La1.2Sr1.8Mn2O7 have been reviewed. The complete set of exchange interactions have been determined on the basis of a localized Heisenberg model. However, the spin wave dispersion in La1.2Sr1.8Mn2O7 shows softening close to the zone boundary and are also heavily damped especially close to the zone boundary and deviate from that expected for a simple Heisenberg model. A minimal double exchange model including quantum corrections can reproduce these effects qualitatively but falls short of quantitative agreement.

  17. Self healing nature of bilayer graphene

    Science.gov (United States)

    Debroy, Sanghamitra; Pavan Kumar Miriyala, V.; Vijaya Sekhar, K.; Acharyya, Swati Ghosh; Acharyya, Amit

    2016-08-01

    The phenomenon of self healing of cracks in bilayer graphene sheet has been studied using molecular dynamics simulations. The bilayer graphene sheet was subjected to uniaxial tensile load resulting in initiation and propagation of cracks on exceeding the ultimate tensile strength. Subsequently, all forces acting on the sheet were removed and sheet was relaxed. The cracks formed in the graphene sheet healed without any external aid within 0.4 ps The phenomenon of self healing of the cracks in graphene sheet was found to be independent of the length of the crack, but occurred for critical crack opening distance less than 5 Å for AA stacked sheet and 13 Å for AB stacked bilayer graphene sheet. Self healing was observed for both AB (mixed stacking of armchair and zigzag graphene sheet) and AA (both sheets of similar orientation i.e. either armchair-armchair or zigzag-zigzag) stacking of bilayer graphene sheet.

  18. Proximity induced superconductivity in bilayer graphene

    Energy Technology Data Exchange (ETDEWEB)

    Bordaz, Julien; Wu, Fan [Institute of Nanotechnology, Karlsruhe Institute of Technology (Germany); Wolf, Michael; Beckmann, Detlef [Institute of Nanotechnology, Karlsruhe Institute of Technology (Germany); DFG Center for Functional Nanostructures, Karlsruhe Institute of Technology (Germany); Loehneysen, Hilbert von [Institute of Nanotechnology, Karlsruhe Institute of Technology (Germany); DFG Center for Functional Nanostructures, Karlsruhe Institute of Technology (Germany); Institute of Physics, Karlsruhe Institute of Technology (Germany); Institute for Solid-State Physics, Karlsruhe Institute of Technology (Germany); Watanabe, Kenji; Taniguchi, Takashi [Advanced Materials Laboratory, National Institute for Materials Science, Tsukuba (Japan); Danneau, Romain [Institute of Nanotechnology, Karlsruhe Institute of Technology (Germany); Institute of Physics, Karlsruhe Institute of Technology (Germany)

    2013-07-01

    Proximity induced superconductivity effect occurs when graphene is connected with close enough superconducting electrodes. Observations of Andreev reflection and induced supercurrents flowing through graphene sheets have already been reported in graphene. However, these effects have not been explored in bilayer graphene so far. By applying a perpendicular electric field, it is possible to open a gap in a bilayer graphene. This can be achieved in practice by designing a top gate in addition to the usual back gate. Our devices are produced on top of sapphire wafers by using transfer techniques and standard electron-beam lithography. The bilayers are sandwiched between two atomically flat hexagonal boron nitride multilayers which are both used as gate dielectric. By inducing a band gap into a bilayer graphene connected by two superconducting leads, the supercurrent could be switched off inducing a superconductor-insulator transition.

  19. Proximity induced superconductivity in bilayer graphene

    International Nuclear Information System (INIS)

    Proximity induced superconductivity effect occurs when graphene is connected with close enough superconducting electrodes. Observations of Andreev reflection and induced supercurrents flowing through graphene sheets have already been reported in graphene. However, these effects have not been explored in bilayer graphene so far. By applying a perpendicular electric field, it is possible to open a gap in a bilayer graphene. This can be achieved in practice by designing a top gate in addition to the usual back gate. Our devices are produced on top of sapphire wafers by using transfer techniques and standard electron-beam lithography. The bilayers are sandwiched between two atomically flat hexagonal boron nitride multilayers which are both used as gate dielectric. By inducing a band gap into a bilayer graphene connected by two superconducting leads, the supercurrent could be switched off inducing a superconductor-insulator transition.

  20. The magnetic ratchet effect in bilayer graphene

    Science.gov (United States)

    McCann, Edward; Kheirabadi, Narjes; Fal'Ko, Vladimir

    Experiments have measured a magnetic ratchet effect for electrons in hydrogenated monolayer graphene, an effect in which a d.c. electric current is generated from an a.c. electric field in the presence of an in-plane magnetic field and spatial asymmetry. Here, we describe the theory of the magnetic ratchet effect in bilayer graphene. The Boltzmann kinetic equation is used to relate the d.c. current to the scattering probability of electrons in bilayer graphene. Taking into account details of the low-energy band structure of bilayer graphene, including interlayer hopping parameters, we compare contributions arising from gate- and disorder-induced spatial asymmetry, illustrating that bilayer and multilayer graphenes are natural candidates for the study of non-linear transport effects.

  1. Molecular dynamics simulations of the interactions of DMSO, mono- and polyhydroxylated cryosolvents with a hydrated phospholipid bilayer.

    Science.gov (United States)

    Malajczuk, Chris J; Hughes, Zak E; Mancera, Ricardo L

    2013-09-01

    Molecular dynamics (MD) simulations have been used to investigate the interactions of a variety of hydroxylated cryosolvents (glycerol, propylene glycol and ethylene glycol), methanol and dimethyl sulfoxide (DMSO) in aqueous solution with a 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) bilayer in its fluid phase at 323K. Each cryosolvent induced lateral expansion of the membrane leading to thinning of the bilayer and resulting in disordering of the lipid hydrocarbon chains. Propylene glycol and DMSO were observed to exhibit a greater disordering effect on the structure of the membrane than the other three alcohols. Closer examination exposed a number of effects on the lipid bilayer as a function of the molecular size and hydrogen bonding capacity of the cryosolvents. Analyses of hydrogen bonds revealed that increased concentrations of the polyhydroxylated cryosolvents induced the formation of a cross-linked cryosolvent layer across the surface of the membrane bilayer. This effect was most pronounced for glycerol at sufficiently high concentrations, which displayed a comparatively enhanced capacity to induce cross-linking of lipid headgroups resulting in the formation of extensive hydrogen bonding bridges and the promotion of a dense cryosolvent layer across the phospholipid bilayer. PMID:23707690

  2. Lipid bilayers decorated with photosensitive ruthenium complexes

    OpenAIRE

    Bahreman, Azadeh

    2013-01-01

    In this thesis the thermal- and photo-substitution behavior of polypyridyl ruthenium complexes is described at the surface of lipid bilayers and in homogeneous solutions. It is shown that the successive thermal binding and light-induced unbinding of the cationic ruthenium complex at the surface of the lipid bilayer requires negatively charged liposomes and ruthenium complexes containing moderately hindered N-N bidentate ligands. Our results in homogeneous solution show that changing the steri...

  3. Twisted bi-layer graphene: microscopic rainbows

    OpenAIRE

    Campos-Delgado, J.; Algara-Siller, G.; Santos, C. N.; Kaiser, U.; Raskin, J.-P.

    2013-01-01

    Twisted bi-layer graphene (tBLG) has recently attracted interest due to the peculiar electrical properties that arise from its random rotational configurations. Our experiments on CVD-grown graphene from Cu foil and transferred onto Si substrates, with an oxide layer of 100 nm, reveal naturally-produced bi-layer graphene patches which present different colorations when shined with white light. In particular yellow-, pink- and blue- colored areas are evidenced. Combining optical microscopy, Ra...

  4. Silica-based cationic bilayers as immunoadjuvants

    OpenAIRE

    Carmona-Ribeiro Ana M; da Costa Maria; Faquim-Mauro Eliana; Santana Mariana RA; Lincopan Nilton

    2009-01-01

    Abstract Background Silica particles cationized by dioctadecyldimethylammonium bromide (DODAB) bilayer were previously described. This work shows the efficiency of these particulates for antigen adsorption and presentation to the immune system and proves the concept that silica-based cationic bilayers exhibit better performance than alum regarding colloid stability and cellular immune responses for vaccine design. Results Firstly, the silica/DODAB assembly was characterized at 1 mM NaCl, pH 6...

  5. Bilayers merge even when exocytosis is transient

    OpenAIRE

    Taraska, Justin W; Almers, Wolfhard

    2004-01-01

    During exocytosis, the lumen of secretory vesicles connects with the extracellular space. In some vesicles, this connection closes again, causing the vesicle to be recaptured mostly intact. The degree to which the bilayers of such vesicles mix with the plasma membrane is unknown. Work supporting the kiss-and-run model of transient exocytosis implies that synaptic vesicles allow neither lipid nor protein to escape into the plasma membrane, suggesting that the two bilayers never merge. Here, we...

  6. Generalized Gaussian Bridges

    CERN Document Server

    Sottinen, Tommi

    2012-01-01

    A generalized bridge is the law of a stochastic process that is conditioned on linear functionals of its path. We consider two types of representations of such bridges: orthogonal and canonical. In the canonical representation the filtrations and the linear spaces generated by the bridge process and the original process coincide. In the orthogonal representation the bridge is constructed from the entire path of the underlying process. The orthogonal representation is given for any continuous Gaussian process but the canonical representation is given only for so-called prediction-invertible Gaussian processes. Finally, we apply the canonical bridge representation to insider trading by interpreting the bridge from an initial enlargement of filtration point of view.

  7. Concrete bridge prioritization system

    OpenAIRE

    Kesselring, Debbie Anne

    1995-01-01

    An alternative method of prioritization for concrete bridge maintenance, repair, and rehabilitation activities is required due to the inability of the current system to manage the increasing nmnber of aging concrete bridges. The Concrete Bridge Prioritization System was proposed because of its ability to address the critical technical parameters of safety and cost benefit in prioritization of funding and work allocation. The analysis includes four parts, service life assessment, s...

  8. Bridging the Gap

    DEFF Research Database (Denmark)

    Kramer Overgaard, Majken; Broeng, Jes; Jensen, Monika Luniewska;

    Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures.......Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures....

  9. Bridging the Gap

    OpenAIRE

    Kramer Overgaard, Majken; Broeng, Jes; Jensen, Monika Luniewska; Murdock, Karen; Schmidt, Iben Julie

    2015-01-01

    Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures. Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ve...

  10. RKKY interaction in bilayer graphene

    Science.gov (United States)

    Mohammadi, Yawar; Moradian, Rostam

    2015-12-01

    We study the RKKY interaction between two magnetic impurities located on the same layer (intralayer case) or on different layers (interlayer case) in undoped bilayer graphene (BLG) in the four-bands model, by directly calculating the Green functions in the eigenvalues and eigenvectors representation. Our results show that both intra- and interlayer RKKY interactions between two magnetic impurities located on the same (opposite) sublattice are always ferromagnetic (antiferromagnetic). Furthermore we find unusual long-distance decay of the RKKY interaction in BLG. The intralyer RKKY interactions between two magnetic impurities located on the same sublattice, J AnAn(R) and J BnBn(R), decay closely as 1 /R6 and 1 /R2 at large impurity distances respectively, but when they are located on opposite sublattices the RKKY interactions exhibit 1 /R4 decays approximately. In the interlayer case, the RKKY interactions between two magnetic impurities located on the same sublattice show a decay close to 1 /R4 at large impurity distances, but if two magnetic impurities be on opposite sublattices the RKKY interactions, J A1B2(R) and J B1A2(R), decay closely as 1 /R6 and 1 /R2 respectively. Both intra- and interlayer RKKY interactions have anisotropic oscillatory factors which for intralayer case is equal to that for single layer graphene (SLG). Our results at weak and strong interlayer coupling limits reduce to the RKKY interaction of SLG and that of BLG in the two-bands approximation respectively.

  11. Principles of Bridge Reliability

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Nowak, Andrzej S.

    The paper gives a brief introduction to the basic principles of structural reliability theory and its application to bridge engineering. Fundamental concepts like failure probability and reliability index are introduced. Ultimate as well as serviceability limit states for bridges are formulated...

  12. The floating water bridge

    International Nuclear Information System (INIS)

    When high voltage is applied to distilled water filled in two glass beakers which are in contact, a stable water connection forms spontaneously, giving the impression of a floating water bridge. A detailed experimental analysis reveals static and dynamic structures as well as heat and mass transfer through this bridge

  13. Layer resolved capacitive probing of graphene bilayers

    Science.gov (United States)

    Zibrov, Alexander; Parmentier, François; Li, Jia; Wang, Lei; Hunt, Benjamin; Dean, Cory; Hone, James; Taniguchi, Takashi; Watanabe, Kenji; Young, Andrea

    Compared to single layer graphene, graphene bilayers have an additional ``which-layer'' degree of freedom that can be controlled by an external electric field in a dual-gated device geometry. We describe capacitance measurements capable of directly probing this degree of freedom. By performing top gate, bottom gate, and penetration field capacitance measurements, we directly extract layer polarization of both Bernal and twisted bilayers. We will present measurements of hBN encapsulated bilayers at both zero and high magnetic field, focusing on the physics of the highly degenerate zero-energy Landau level in the high magnetic field limit where spin, valley, and layer degeneracy are all lifted by electronic interactions.

  14. Molecular friction and epitactic coupling between monolayers in supported bilayers

    OpenAIRE

    Merkel, R.; Sackmann, E.; Evans, E

    1989-01-01

    Microfluorescence methods were used to examine monolayer-monolayer and bilayer-substrate coupling in bilayers deposited on glass substrates. In the first part, lateral diffusion of lipid probes in individual lipid layers was measured by the fluorescence recovery after photobleach technique. The aim was to evaluate viscous molecular friction (i) between monolayers that form a single bilayer and (ii) between a bilayer and an adjacent substrate based on a recent phenomenological theory for parti...

  15. Thermally activated conductivity in gapped bilayer graphene

    Science.gov (United States)

    Trushin, Maxim

    2012-05-01

    This is a theoretical study of electron transport in gated bilayer graphene —a novel semiconducting material with a tunable band gap. It is shown that the which-layer pseudospin coherence enhances the subgap conductivity and facilitates the thermally activated transport. The mechanism proposed can also lead to the non-monotonic conductivity vs. temperature dependence at a band gap size of the order of 10 meV. The effect can be observed in gapped bilayer graphene sandwiched in boron nitride where the electron-hole puddles and flexural phonons are strongly suppressed.

  16. Bridge technology report

    CERN Document Server

    2013-01-01

    Please note this is a Short Discount publication. As LANs have proliferated, new technologies and system concepts have come to the fore. One of the key issues is how to interconnect networks. One means of interconnection is to use a 'bridge'. Other competing technologies are repeaters, routers, and gateways. Bridges permit traffic isolation, connect network segments together and operate at the MAC layer. Further, because they operate at the MAC layer, they can handle a variety of protocols such as TCP/IP, SNA, and X.25. This report focuses on the specific technology of bridging two netw

  17. Bridge Management Systems:present and future

    OpenAIRE

    Thoft-Christensen, Palle

    1997-01-01

    In this paper bridge management systems are discussed with special emphasis on management systems for reinforced concrete bridges. Management systems for prestressed concrete bridges, steel bridges, or composite bridges can be developed in a similar way.

  18. Bridging a cultural gap

    Science.gov (United States)

    Leviatan, Talma

    2008-09-01

    There has been a broad wave of change in tertiary calculus courses in the past decade. However, the much-needed change in tertiary pre-calculus programmes—aimed at bridging the gap between high-school mathematics and tertiary mathematics—is happening at a far slower pace. Following a discussion on the nature of the gap and the objectives of a potential bridging programme, this paper aims at demonstrating that the gap can be bridged, by presenting an ongoing modular bridging programme especially designed for the diverse types of student populations in teachers training colleges. We also present here some innovative teaching and assessment methods that were judged essential for the success of these programmes—focusing mainly on the "Questionnaire Based Instruction Method". Finally we suggest directions of follow up and research.

  19. Bridged Race Population Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — Population estimates from "bridging" the 31 race categories used in Census 2000, as specified in the 1997 Office of Management and Budget (OMB) race and ethnicity...

  20. In situ atomic force microscope imaging of supported lipid bilayers

    DEFF Research Database (Denmark)

    Kaasgaard, Thomas; Leidy, Chad; Ipsen, John Hjorth;

    2001-01-01

    In situ AFM images of phospholipase A/sub 2/ (PLA/sub 2/) hydrolysis of mica-supported one- and two-component lipid bilayers are presented. For one-component DPPC bilayers an enhanced enzymatic activity is observed towards preexisting defects in the bilayer. Phase separation is observed in two......-component DMPC-DSPC bilayers and a remarkable enhanced hydrolytic activity of the PLA/sub 2/-enzyme for the DMPC-rich phase is seen. Furthermore, in a supported double bilayer system a characteristic ripple structure, most likely related to the formation of the P/sub beta /-ripple phase is observed....

  1. Electronic properties of graphene-based bilayer systems

    Science.gov (United States)

    Rozhkov, A. V.; Sboychakov, A. O.; Rakhmanov, A. L.; Nori, Franco

    2016-08-01

    This article reviews the theoretical and experimental work related to the electronic properties of bilayer graphene systems. Three types of bilayer stackings are discussed: the AA, AB, and twisted bilayer graphene. This review covers single-electron properties, effects of static electric and magnetic fields, bilayer-based mesoscopic systems, spin-orbit coupling, dc transport and optical response, as well as spontaneous symmetry violation and other interaction effects. The selection of the material aims to introduce the reader to the most commonly studied topics of theoretical and experimental research in bilayer graphene.

  2. Lipid bilayers decorated with photosensitive ruthenium complexes

    NARCIS (Netherlands)

    Bahreman, Azadeh

    2013-01-01

    In this thesis the thermal- and photo-substitution behavior of polypyridyl ruthenium complexes is described at the surface of lipid bilayers and in homogeneous solutions. It is shown that the successive thermal binding and light-induced unbinding of the cationic ruthenium complex at the surface of t

  3. Topological transformation of a surfactant bilayer

    DEFF Research Database (Denmark)

    Le, T.D.; Olsson, U.; Mortensen, K.

    2000-01-01

    Surfactant lamellar phases are often complicated by the formation of multilamellar (onions) under shear, which can originate simply by shaking the sample. A systematic study has been performed on the C10E3-D2O system in which different bilayer structures under a steady shear flow were investigated...

  4. Chiral electron transport in CVD bilayer graphene

    Science.gov (United States)

    Lee, Kyunghoon; Eo, Yun Suk; Kurdak, Cagliyan; Zhong, Zhaohui

    2014-03-01

    Charge carriers in bilayer graphene have a parabolic energy spectrum. Due to this band structure they are massive quasiparticles having a finite density of state at zero energy like other non-relativistic charge carriers in conventional two dimensional materials. However, they are massive Dirac fermions which have a chiral nature similar to the case of massless Dirac fermions in single layer graphene. Coupling of pseudospin and motion of charge carrier via chirality can result in dramatic consequence for transport in bipolar regime like Klein tunneling, Fabry-Perot interference, collimation of charge carrier, Veslago lens, etc. However, little attention has been paid to chiral dependent electron transport in bilayer graphene. Here we study these properties by probing phase coherent transport behavior in CVD bilayer graphene devices with sub-200nm channel length. Complex Fabry-Perot interference patterns are observed in resonant cavities defined by local gating. By applying Fourier analysis technique, we successfully analyze and identify the origin of each individual interference pattern in bipolar and monopolar regime. Our initial results also hint at the observation of cloaking of electronic states against chiral electrons in bilayer graphene.

  5. Superconducting Calcium-Intercalated Bilayer Graphene.

    Science.gov (United States)

    Ichinokura, Satoru; Sugawara, Katsuaki; Takayama, Akari; Takahashi, Takashi; Hasegawa, Shuji

    2016-02-23

    We report the direct evidence for superconductivity in Ca-intercalated bilayer graphene C6CaC6, which is regarded as the thinnest limit of Ca-intercalated graphite. We performed the electrical transport measurements with the in situ 4-point-probe method in ultrahigh vacuum under zero- or nonzero-magnetic field for pristine bilayer graphene, Li-intercalated bilayer graphene (C6LiC6) and C6CaC6 fabricated on SiC substrate. We observed that the zero-resistance state occurs in C6CaC6 with the onset temperature (Tc(onset)) of 4 K, while the Tc(onset) is gradually decreased upon applying the magnetic field. This directly proves the superconductivity origin of the zero resistance in C6CaC6. On the other hand, both pristine bilayer graphene and C6LiC6 exhibit nonsuperconducting behavior, suggesting the importance of intercalated atoms and its species to drive the superconductivity. PMID:26815333

  6. Localized plasmons in bilayer graphene nanodisks

    DEFF Research Database (Denmark)

    Wang, Weihua; Xiao, Sanshui; Mortensen, N. Asger

    2016-01-01

    We study localized plasmonic excitations in bilayer graphene (BLG) nanodisks, comparing AA-stacked and AB-stacked BLG and contrasting the results to the case of two monolayers without electronic hybridization. The electrodynamic response of the BLG electron gas is described in terms of a spatially...

  7. Bilayer Tablet via Microsphere: A Review

    Directory of Open Access Journals (Sweden)

    Piyushkumar Vinubhai Gundaraniya

    2013-01-01

    Full Text Available The aim of the present work is to develop bilayer tablets containing sustained release microspheres as one layer and immediate release as another layer. The proposed dosage form is intended to decrease the dosing frequency and the combined administration of an anti-diabetic agent. Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anti-diabetic drugs. Bilayer tablet via microsphere is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Especially when in addition high production output is required. An attempt has been made in this review article to introduce the society to the current technological developments in bilayer and floating drug delivery system.

  8. Integral Abutment and Jointless Bridges

    OpenAIRE

    Cristian-Claudiu Comisu

    2005-01-01

    Integral bridges, or integral abutment and jointless bridges, as they are more commonly known in the USA, are constructed without any movement joints between spans or between spans and abutments. Typically these bridges have stub-type abutments supported on piles and continuous bridge deck from one embankment to the other. Foundations are usually designed to be small and flexible to facilitate horizontal movement or rocking of the support. Integrally bridges are simple or multiple span ones t...

  9. Repetitive formation of optically-observable planar lipid bilayers by rotating chambers on a microaperture.

    Science.gov (United States)

    Tomoike, Fumiaki; Tonooka, Taishi; Osaki, Toshihisa; Takeuchi, Shoji

    2016-07-01

    Optical observation of a planar lipid bilayer is an effective method of lipid bilayer characterization. However, previous methods for optically observable lipid bilayer formation are unsuitable for repetitive formation of lipid bilayers. In this paper, we propose a system that facilitates repetitive formation of horizontal lipid bilayers via mechanical rotation of the rotating part. We show that multiple bilayers can be observed within a short period, and that the electrical and optical characteristics of a bilayer can be analyzed simultaneously. PMID:27256329

  10. Istanbul Bridge Conference 2014

    CERN Document Server

    Gülkan, Polat; Mahmoud, Khaled

    2016-01-01

      The book includes peer-reviewed contributions selected from presentations given at the Istanbul Bridge Conference 2014, held from August 11 – 13 in Istanbul, Turkey. It reports on the current challenges in bridge engineering faced by professionals around the globe, giving a special emphasis to recently developed techniques, innovations and opportunities. The book covers key topics in the field, including modeling and analysis methods; construction and erection techniques; design for extreme events and condition assessment and structural health monitoring. There is a balanced presentation of theory, research and practice. This book, which provides the readers with a comprehensive and timely reference guide on current practices in bridge engineering, is intended for professionals, academic researchers and students alike.

  11. Active Control of Suspension Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper some recent research on active control of very long suspension bridges, is presented. The presentation is based on research work at Aalborg University, Denmark. The active control system is based on movable flaps attached to the bridge girder. Wind load on bridges with or without...... flaps attached to the girder is briefly presented. A simple active control system is discussed. Results from wind tunnel experiments with a bridge section show that flaps can be used effectively to control bridge girder vibrations. Flutter conditions for suspension bridges with and without flaps are...

  12. Polymer bilayer structure via inkjet printing

    Science.gov (United States)

    Xia, Yajun; Friend, Richard H.

    2006-04-01

    We report the formation of a polymer bilayer structure by inkjet printing poly(9,9'-dioctylfluorene-co-benzothiadiazole) (F8BT) from p-xylene solution onto a poly(9,9-dioctylfluorene-co-N-(4-butylphenyl)diphenylamine (TFB) thin film. Despite the compatibility of both polymers with the same organic solvent, a TFB layer under the later-deposited F8BT was directly observed through fluorescence microscopy. Micro-Raman spectroscopy reveals that this bottom layer is ˜10nm thick for a film made by inkjet printing F8BT onto a TFB film of ˜20nm thickness. The bilayer structure leads to enhanced efficiency for light-emitting diodes in comparison with devices made from spin-coated TFB:F8BT blend films.

  13. The surface layer of cleaved bilayer manganites

    International Nuclear Information System (INIS)

    Recently, several informative reports have been published on spectroscopy experiments performed on cleaved surfaces of the bilayered colossal magnetoresistive manganite La2-2xSr1+2xMn2O7 (Konoto et al 2004 Phys. Rev. Lett. 93 107201, Freeland et al 2005 Nat. Mater. 4 62, Mannella et al 2005 Nature 438 474, Roennow et al 2006 Nature 440 1025). For the detailed interpretation of these results, it is of importance to know exactly which layer within the crystal structure is exposed to the surface upon cleavage. Here we combine crystal structure arguments, scanning tunnelling microscopy and x-ray photoelectron spectroscopy measurements to demonstrate that the crystals cleave between the rare-earth rock-salt oxide layers, leaving one outermost rare-earth oxide layer before the first electronically active MnO bilayer

  14. Negative differential resistance in bilayer graphene nanoribbons

    OpenAIRE

    Zahid, F.; Habib, KMM; Lake, RK

    2011-01-01

    Lack of a bandgap is one of the significant challenges for application of graphene as the active element of an electronic device. A bandgap can be induced in bilayer graphene by application of a potential difference between the two layers. The simplest geometry for creating such a potential difference is two overlayed graphene nanoribbons independently contacted. Calculations, based on density functional theory and the nonequilibrium Green's function formalism, show that transmission through ...

  15. Lipid Bilayers: Clusters, Domains and Phases

    OpenAIRE

    Ackerman, David G.; Feigenson, Gerald W.

    2015-01-01

    In this chapter we discuss the complex mixing behavior of plasma membrane lipids. To do so, we first introduce the plasma membrane and membrane mixtures often used to model its complexity. We then discuss the nature of lipid phase behavior in bilayers and the distinction between these phases and other manifestations of nonrandom mixing found in one-phase mixtures, such as clusters, micelles, and microemulsions. Finally, we demonstrate the applicability of Gibbs phase diagrams to the study of ...

  16. Interaction of small peptides with lipid bilayers.

    OpenAIRE

    Damodaran, K. V.; Merz, K M; Gaber, B P

    1995-01-01

    Molecular dynamics simulations of the tripeptide Ala-Phe-Ala-O-tert-butyl interacting with dimyristoylphosphatidylcholine lipid bilayers have been carried out. The lipid and aqueous environments of the peptide, the alkyl chain order, and the lipid and peptide dynamics have been investigated with use of density profiles, radial distribution functions, alkyl chain order parameter profiles, and time correlation functions. It appears that the alkyl chain region accommodates the peptides in the bi...

  17. Edge states of zigzag bilayer graphite nanoribbons

    OpenAIRE

    Rhim, Jun-Won; Moon, Kyungsun

    2008-01-01

    Electronic structures of the zigzag bilayer graphite nanoribbons(Z-BGNR) with various ribbon width $N$ are studied within the tight binding approximation. Neglecting the inter-layer hopping amplitude $\\gamma_4$, which is an order of magnitude smaller than the other inter-layer hopping parameters $\\gamma_1$ and $\\gamma_3$, there exist two fixed Fermi points $\\pm k^*$ independent of the ribbon width with the peculiar energy dispersion near $k^*$ as $\\ve (k) \\sim \\pm (k-k^*)^N$. By investigating...

  18. Sub-diffraction imaging with compensating bilayers

    International Nuclear Information System (INIS)

    We derive a general expression for the material properties of a compensating bilayer, which is a pair of material layers which transfer the field distribution from one side of the bilayer to the other with resolution limited only by the deviation of the material properties from specified values. One of the layers can be free space, a special case of which is the perfect lens, but the layers need not have equal thickness. Compensating a thick layer of free space with a thin layer creates a focusing device with increased working distance, and employs an anisotropic material. It is also possible to achieve compensation of materials with property tensors that are neither positive nor negative definite. In this case, we refer to such media as indefinite, and we analyse, in detail, bilayers of these media which support coupling of internal propagating waves to incident waves of any transverse wave vector. In this case, we find that the enhanced spatial resolution provided by large transverse wave vectors is far less sensitive to loss than that of the perfect lens

  19. Stability analysis of the pulmonary liquid bilayer.

    Science.gov (United States)

    Halpern, David; Grotberg, James

    2010-11-01

    The lung consists of liquid-lined compliant airways that convey air to and from the alveoli where gas exchange takes place. Because the airways are coated with a bilayer consisting of a mucus layer on top of a periciliary fluid layer, a surface tension instability can generate flows within the bilayer and induce the formation of liquid plugs that block the passage of air. This is a problem for example with premature neonates whose lungs do not produce sufficient quantities of surfactant and suffer from respiratory distress syndrome. To study this instability a system of coupled nonlinear evolution equations are derived using lubrication theory for the thicknesses of the two liquid layers which are assumed to be Newtonian. A normal mode analysis is used to investigate the initial growth of the disturbances, and reveals how the grow rate is affected by the ratio of viscosities λ, film thicknesses η and surface tensions δ of the two layers which can change by disease. Numerical solutions of the evolution equations show that there is a critical bilayer thickness ɛc above which closure occurs, and that a more viscous and thicker layer compared to the periciliary layer closes more slowly. However, ɛcis weakly dependent on λ, η and δ. We also examine the potential impact of wall shear stress and normal stress on cell damage. This work is funded by NIH HL85156.

  20. Self-folding graphene-polymer bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Tao [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China); Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Yoon, ChangKyu [Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Jin, Qianru [Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Li, Mingen [Department of Physics, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Liu, Zewen [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China); Gracias, David H., E-mail: dgracias@jhu.edu [Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States)

    2015-05-18

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  1. Self-folding graphene-polymer bilayers

    Science.gov (United States)

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-01

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  2. Electronic structure theory of weakly interacting bilayers

    Science.gov (United States)

    Fang, Shiang; Kaxiras, Efthimios

    2016-06-01

    We derive electronic structure models for weakly interacting bilayers such as graphene-graphene and graphene-hexagonal boron nitride, based on density functional theory calculations followed by Wannier transformation of electronic states. These transferable interlayer coupling models can be applied to investigate the physics of bilayers with arbitrary translations and twists. The functional form, in addition to the dependence on the distance, includes the angular dependence that results from higher angular momentum components in the Wannier pz orbitals. We demonstrate the capabilities of the method by applying it to a rotated graphene bilayer, which produces the analytically predicted renormalization of the Fermi velocity, Van Hove singularities in the density of states, and moiré pattern of the electronic localization at small twist angles. We further extend the theory to obtain the effective couplings by integrating out neighboring layers. This approach is instrumental for the design of van der Walls heterostructures with desirable electronic features and transport properties and for the derivation of low-energy theories for graphene stacks, including proximity effects from other layers.

  3. Automatable lipid bilayer formation for ion channel studies

    Science.gov (United States)

    Poulos, Jason L.; Bang, Hyunwoo; Jeon, Tae-Joon; Schmidt, Jacob J.

    2008-08-01

    Transmembrane proteins and ion channels are important drug targets and have been explored as single molecule sensors. For these proteins to function normally they must be integrated within lipid bilayers; however, the labor and skill required to create artificial lipid bilayers have the limited the possible applications utilizing these proteins. In order to reduce the complexity and cost of lipid bilayer formation and measurement, we have modified a previously published lipid bilayer formation technique using mechanically contacted monolayers so that the process is automatable, requiring minimal operator input. Measurement electronics are integrated with the fluid handling system, greatly reducing the time and operator feedback characteristically required of traditional bilayer experiments. To demonstrate the biological functionality of the resultant bilayers and the system's capabilities as a membrane platform, the ion channel gramicidin A was incorporated and measured with this system.

  4. Molecular dynamics modelling of EGCG clusters on ceramide bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Yeo, Jingjie; Cheng, Yuan; Li, Weifeng; Zhang, Yong-Wei [Institute of High Performance Computing, A*STAR, 138632 (Singapore)

    2015-12-31

    A novel method of atomistic modelling and characterization of both pure ceramide and mixed lipid bilayers is being developed, using only the General Amber ForceField. Lipid bilayers modelled as pure ceramides adopt hexagonal packing after equilibration, and the area per lipid and bilayer thickness are consistent with previously reported theoretical results. Mixed lipid bilayers are modelled as a combination of ceramides, cholesterol, and free fatty acids. This model is shown to be stable after equilibration. Green tea extract, also known as epigallocatechin-3-gallate, is introduced as a spherical cluster on the surface of the mixed lipid bilayer. It is demonstrated that the cluster is able to bind to the bilayers as a cluster without diffusing into the surrounding water.

  5. Building Migratory Bridges

    Science.gov (United States)

    Roy, Michael; Doss, Laurie K.

    2007-01-01

    The Building Migratory Bridges (BOMB) program--a collaboration between the Marvel wood School and Audubon Sharon in Connecticut and Conservation Research Education Action (CR EA), a U.S. not-for-profit in Panama--uses nontropical migratory bird research in the United States and Panama to demonstrate how negative environmental impacts in one…

  6. Quantum Bidding in Bridge

    Science.gov (United States)

    Muhammad, Sadiq; Tavakoli, Armin; Kurant, Maciej; Pawłowski, Marcin; Żukowski, Marek; Bourennane, Mohamed

    2014-04-01

    Quantum methods allow us to reduce communication complexity of some computational tasks, with several separated partners, beyond classical constraints. Nevertheless, experimental demonstrations of this have thus far been limited to some abstract problems, far away from real-life tasks. We show here, and demonstrate experimentally, that the power of reduction of communication complexity can be harnessed to gain an advantage in a famous, immensely popular, card game—bridge. The essence of a winning strategy in bridge is efficient communication between the partners. The rules of the game allow only a specific form of communication, of very low complexity (effectively, one has strong limitations on the number of exchanged bits). Surprisingly, our quantum technique does not violate the existing rules of the game (as there is no increase in information flow). We show that our quantum bridge auction corresponds to a biased nonlocal Clauser-Horne-Shimony-Holt game, which is equivalent to a 2→1 quantum random access code. Thus, our experiment is also a realization of such protocols. However, this correspondence is not complete, which enables the bridge players to have efficient strategies regardless of the quality of their detectors.

  7. Bridge of Light

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Lying gleaming white under a brooding sky,the Lhasa River Railway Bridge forms a gate to Lhasa City.Built as a part of Qinghai-Tibet Railway,on July 1,2011, the highest altitude railway in the world has been in service for five years. Lhasa,Tibet

  8. Bridge over troubled water?

    DEFF Research Database (Denmark)

    Svendsen, Gunnar Lind Haase; Nannestad, Peter; Svendsen, Gert Tinggaard

    2008-01-01

    The problem of integrating non-Western immigrants into Western welfare states is the focus of this paper. To address this issue, we suggest a social capital approach in which we apply the conceptual pair of bridging social capital (BR), which connects an individual to the broader social structure...

  9. Supercurrent reversal in Josephson junctions based on bilayer graphene flakes

    OpenAIRE

    Rameshti, Babak Zare; Zareyan, Malek; Moghaddam, Ali G.

    2015-01-01

    We investigate the Josephson effect in a bilayer graphene flake contacted by two monolayer sheet deposited by superconducting electrodes. It is found that when the electrodes are attached to the different layers of the bilayer, the Josephson current is in a $\\pi$ state when the bilayer region is undoped and in the absence of vertical bias. Applying doping or bias to the junction reveals $\\pi-0$ transitions which can be controlled by varying the temperature and the junction length. The supercu...

  10. Ionic motion in PEDOT and PPy conducting polymer bilayers

    DEFF Research Database (Denmark)

    Zainudeen, Umer L.; Careem, M.A.; Skaarup, Steen

    2006-01-01

    Conducting polymer bilayers with poly(3,4-ethylenedioxythiophene) (PEDOT) and polypyrrole (PPy), each containing dodecyl benzenesulfonate (DBS) as immobile dopant species, were synthesized galvanostatically. The electrochemical behaviour of the bilayers was investigated using cyclic voltammetry......, optical absorption spectroscopy and electrochemical quartz crystal microbalance (EQCM) techniques. Two important conclusions of relevance for actuator performance were reached: It is possible to make a bilayer film that does not delaminate – the two polymers are compatible; and both polymers are active in...

  11. Intercalation of small hydrophobic molecules in lipid bilayers containing cholesterol

    Energy Technology Data Exchange (ETDEWEB)

    Worcester, D.L.; Hamacher, K.; Kaiser, H.; Kulasekere, R.; Torbet, J. [Univ. of Missouri, Columbia, MO (United States)

    1994-12-31

    Partitioning of small hydrophobic molecules into lipid bilayers containing cholesterol has been studied using the 2XC diffractometer at the University of Missouri Research Reactor. Locations of the compounds were determined by Fourier difference methods with data from both deuterated and undeuterated compounds introduced into the bilayers from the vapor phase. Data fitting procedures were developed for determining how well the compounds were localized. The compounds were found to be localized in a narrow region at the center of the hydrophobic layer, between the two halves of the bilayer. The structures are therefore intercalated structures with the long axis of the molecules in the plane of the bilayer.

  12. Synthesis and sensing application of large scale bilayer graphene

    Science.gov (United States)

    Hong, Sung Ju; Yoo, Jung Hoon; Baek, Seung Jae; Park, Yung Woo

    2012-02-01

    We have synthesized large scale bilayer graphene by using Chemical Vapor Deposition (CVD) in atmospheric pressure. Bilayer graphene was grown by using CH4, H2 and Ar gases. The growth temperature was 1050^o. Conventional FET measurement shows ambipolar transfer characteristics. Results of Raman spectroscopy, Atomic Force microscope (AFM) and Transmission Electron Microscope (TEM) indicate the film is bilayer graphene. Especially, adlayer structure which interrupt uniformity was reduced in low methane flow condition. Furthermore, large size CVD bilayer graphene film can be investigated to apply sensor devices. By using conventional photolithography process, we have fabricated device array structure and studied sensing behavior.

  13. Intercalation of small hydrophobic molecules in lipid bilayers containing cholesterol

    International Nuclear Information System (INIS)

    Partitioning of small hydrophobic molecules into lipid bilayers containing cholesterol has been studied using the 2XC diffractometer at the University of Missouri Research Reactor. Locations of the compounds were determined by Fourier difference methods with data from both deuterated and undeuterated compounds introduced into the bilayers from the vapor phase. Data fitting procedures were developed for determining how well the compounds were localized. The compounds were found to be localized in a narrow region at the center of the hydrophobic layer, between the two halves of the bilayer. The structures are therefore intercalated structures with the long axis of the molecules in the plane of the bilayer

  14. Revised Rules for Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Jensen, F. M.; Middleton, C.; Blackmore, A.

    This paper is based on research performed for the Highway Agency, London, UK under the project DPU/9/44 "Revision of Bridge Assessment Rules Based on Whole Life Performance: Concrete Bridges" It contains details of a methodology which can be used to generate Whole Life (WL) reliability profiles....... These WL reliability profiles may be used to establish revised rules for Concrete Bridges....

  15. Direct in situ measurement of specific capacitance, monolayer tension, and bilayer tension in a droplet interface bilayer.

    Science.gov (United States)

    Taylor, Graham J; Venkatesan, Guru A; Collier, C Patrick; Sarles, Stephen A

    2015-10-14

    Thickness and tension are important physical parameters of model cell membranes. However, traditional methods to measure these quantities require multiple experiments using separate equipment. This work introduces a new multi-step procedure for directly accessing in situ multiple physical properties of droplet interface bilayers (DIB), including specific capacitance (related to thickness), lipid monolayer tension in the Plateau-Gibbs border, and bilayer tension. The procedure employs a combination of mechanical manipulation of bilayer area followed by electrowetting of the capacitive interface to examine the sensitivities of bilayer capacitance to area and contact angle to voltage, respectively. These data allow for determining the specific capacitance of the membrane and surface tension of the lipid monolayer, which are then used to compute bilayer thickness and tension, respectively. The use of DIBs affords accurate optical imaging of the connected droplets in addition to electrical measurements of bilayer capacitance, and it allows for reversibly varying bilayer area. After validating the accuracy of the technique with diphytanoyl phosphatidylcholine (DPhPC) DIBs in hexadecane, the method is applied herein to quantify separately the effects on membrane thickness and tension caused by varying the solvent in which the DIB is formed and introducing cholesterol into the bilayer. Because the technique relies only on capacitance measurements and optical images to determine both thickness and tension, this approach is specifically well-suited for studying the effects of peptides, biomolecules, natural and synthetic nanoparticles, and other species that accumulate within membranes without altering bilayer conductance. PMID:26289743

  16. Bilayer-thickness-mediated interactions between integral membrane proteins

    Science.gov (United States)

    Kahraman, Osman; Koch, Peter D.; Klug, William S.; Haselwandter, Christoph A.

    2016-04-01

    Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large-scale organization of integral membrane proteins into protein clusters in cell membranes. Within the continuum elasticity theory of membranes, the energy cost of protein-induced bilayer thickness deformations can be captured by considering compression and expansion of the bilayer hydrophobic core, membrane tension, and bilayer bending, resulting in biharmonic equilibrium equations describing the shape of lipid bilayers for a given set of bilayer-protein boundary conditions. Here we develop a combined analytic and numerical methodology for the solution of the equilibrium elastic equations associated with protein-induced lipid bilayer deformations. Our methodology allows accurate prediction of thickness-mediated protein interactions for arbitrary protein symmetries at arbitrary protein separations and relative orientations. We provide exact analytic solutions for cylindrical integral membrane proteins with constant and varying hydrophobic thickness, and develop perturbative analytic solutions for noncylindrical protein shapes. We complement these analytic solutions, and assess their accuracy, by developing both finite element and finite difference numerical solution schemes. We provide error estimates of our numerical solution schemes and systematically assess their convergence properties. Taken together, the work presented here puts into place an analytic and numerical framework which allows calculation of bilayer-mediated elastic interactions between integral membrane proteins for the complicated protein shapes suggested by structural biology and at the small protein separations most relevant for the crowded membrane

  17. Effect of monoglycerides and fatty acids on a ceramide bilayer.

    Science.gov (United States)

    Akinshina, Anna; Das, Chinmay; Noro, Massimo G

    2016-07-14

    Monoglycerides and unsaturated fatty acids, naturally present in trace amounts in the stratum corneum (top layer of skin) lipid matrix, are commonly used in pharmaceutical, cosmetic and health care formulations. However, a detailed molecular understanding of how the oil additives get incorporated into the skin lipids from topical application and, once incorporated, how they affect the properties and integrity of the lipid matrix remains unexplored. Using ceramide 2 bilayers as skin lipid surrogates, we use a series of molecular dynamics simulations with six different natural oil ingredients at multiple concentrations to investigate the effect of the oils on the properties and stability of the bilayers. The six oils: monoolein, monostearin, monoelaidin, oleic acid, stearic acid and linoleic acid - all having the same length of the alkyl chain, C18, but a varying degree of saturation, allow us to systematically address the effect of unsaturation in the additives. Our results show that at low oil concentration (∼5%) the mixed bilayers containing any of the oils and ceramide 2 (CER2) become more rigid than pure CER2 bilayers due to more efficient lipid packing. Better packing also results in the formation of larger numbers of hydrogen bonds between the lipids, which occurs at the expense of the hydrogen bonds between lipids and water. The mixed bilayers with saturated or trans-unsaturated oils remain stable over the whole range of oil concentration. In contrast, the presence of the oils with at least one cis-double bond leads to bilayer instability and complete loss of bilayer structure at the oil content of about 50-65%. Two cis-double bonds in the lipid tail induce bilayer disruption at even lower concentration (∼30%). The mixed bilayers remain in the gel phase (without melting to a fluid phase) until the phase transition to a non-bilayer phase occurs. We also demonstrate that the stability of the bilayer strongly correlates with the order parameter of the lipid

  18. [Retention of adhesive bridges].

    Science.gov (United States)

    Raes, F; De Boever, J

    1994-04-01

    Since the development of adhesive bridges in the early seventies, the retention and therefore the durability of these bridges has been tremendously improved. Conditioning of the non-precious metal by silanisation, careful acid etching of the enamel and the use of the appropriate composite resin are of prime importance. Furthermore, the meticulous preparation with enough interproximal embrace, occlusal rests, interocclusal clearance and cingulum stops is equally important. Including more teeth in the design does not necessarily lead to an improved retention. Besides the material and technical aspects, the whole clinical procedure needs much attention. The retention does not depend on one single factor, but on the precision of all the necessary clinical steps and on a well-defined selection of the material. In this way a five-year survival rate of close to 80% can be obtained. PMID:11830965

  19. Nasal Bridge Intramuscular Hemangioma

    OpenAIRE

    Zulkifli Hamir Basah; Irfan Mohamad; Ramiza Ramza Ramli; Maha Khadum Gayadh; Samarendra Singh Mutum

    2015-01-01

    Intramuscular haemangioma (IMH) is a benign mesenchymal tumour. It appears as a deep, nontender mass within the soft tissue, particularly in the extremities. This tumour may not be obvious on clinical examination. Head and neck IMHs represent only 13.5% of the total IMHs. The most common site for a head and neck IMH is the masseter muscle, followed by trapezius, sternocleidomastoid, and very rarely temporalis muscle. We present a patient with left nasal bridge swelling which was excised and h...

  20. BRIDGING SERVICE QUALITY GAPS

    OpenAIRE

    BARKATH UNISSA

    2012-01-01

    Bridging the Service quality gaps is one of the foremost areas of concern for amarketer. Service marketing is inherently different from product or goods marketing.Services are distinctively characterized by their intangible, heterogeneous, inseparableand perishable nature. The importance of the service sector in today's world is a verywidely accepted and renowned idea. “We are already experiencing a service society“services do have some basic characteristics which make them fundamentally diff...

  1. Bridging as Coercive Accommodation

    CERN Document Server

    Bos, J W; Mineur, A M; Bos, Johan; Buitelaar, Paul; Mineur, Anne-Marie

    1995-01-01

    In this paper we discuss the notion of "bridging" in Discourse Representation Theory as a tool to account for discourse referents that have only been established implicitly, through the lexical semantics of other referents. In doing so, we use ideas from Generative Lexicon theory, to introduce antecedents for anaphoric expressions that cannot be "linked" to a proper antecedent, but that do not need to be "accommodated" because they have some connection to the network of discourse referents that is already established.

  2. Nematic liquid crystal bridges

    Science.gov (United States)

    Doss, Susannah; Ellis, Perry; Vallamkondu, Jayalakshmi; Danemiller, Edward; Vernon, Mark; Fernandez-Nieves, Alberto

    We study the effects of confining a nematic liquid crystal between two parallel glass plates with homeotropic boundary conditions for the director at all bounding surfaces. We find that the free surface of the nematic bridge is a surface of constant mean curvature. In addition, by changing the distance between the plates and the contact angle with the glass plates, we transition between loops and hedgehogs that can be either radial or hyperbolic.

  3. Reference hypernetted chain theory for ferrofluid bilayer: distribution functions compared with Monte Carlo.

    Science.gov (United States)

    Polyakov, Evgeny A; Vorontsov-Velyaminov, Pavel N

    2014-08-28

    Properties of ferrofluid bilayer (modeled as a system of two planar layers separated by a distance h and each layer carrying a soft sphere dipolar liquid) are calculated in the framework of inhomogeneous Ornstein-Zernike equations with reference hypernetted chain closure (RHNC). The bridge functions are taken from a soft sphere (1/r(12)) reference system in the pressure-consistent closure approximation. In order to make the RHNC problem tractable, the angular dependence of the correlation functions is expanded into special orthogonal polynomials according to Lado. The resulting equations are solved using the Newton-GRMES algorithm as implemented in the public-domain solver NITSOL. Orientational densities and pair distribution functions of dipoles are compared with Monte Carlo simulation results. A numerical algorithm for the Fourier-Hankel transform of any positive integer order on a uniform grid is presented. PMID:25173007

  4. Membrane-Protein Interactions in a Generic Coarse-Grained Model for Lipid Bilayers

    CERN Document Server

    West, Beate; Schmid, Friederike

    2008-01-01

    We study membrane-protein interactions and membrane-mediated protein-protein interactions by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers with cylindrical hydrophobic inclusions. The strength of the hydrophobic force and the hydrophobic thickness of the proteins are systematically varied. The results are compared with analytical predictions of two popular analytical theories: The Landau-de Gennes theory and the elastic theory. The elastic theory provides an excellent description of the fluctuation spectra of pure membranes and successfully reproduces the deformation profiles of membranes around single proteins. However, its prediction for the potential of mean force between proteins is not compatible with the simulation data for large distances. The simulations show that the lipid-mediated interactions are governed by five competing factors: Direct interactions, lipid-induced depletion interactions, lipid bridging, lipid packing, and a smooth long-range contribution. The mechan...

  5. Bilayer avalanche spin-diode logic

    International Nuclear Information System (INIS)

    A novel spintronic computing paradigm is proposed and analyzed in which InSb p-n bilayer avalanche spin-diodes are cascaded to efficiently perform complex logic operations. This spin-diode logic family uses control wires to generate magnetic fields that modulate the resistance of the spin-diodes, and currents through these devices control the resistance of cascaded devices. Electromagnetic simulations are performed to demonstrate the cascading mechanism, and guidelines are provided for the development of this innovative computing technology. This cascading scheme permits compact logic circuits with switching speeds determined by electromagnetic wave propagation rather than electron motion, enabling high-performance spintronic computing

  6. Giant magnetoresistance in bilayer graphene nanoflakes

    Science.gov (United States)

    Farghadan, Rouhollah; Farekiyan, Marzieh

    2016-09-01

    Coherent spin transport through bilayer graphene (BLG) nanoflakes sandwiched between two electrodes made of single-layer zigzag graphene nanoribbon was investigated by means of Landauer-Buttiker formalism. Application of a magnetic field only on BLG structure as a channel produces a perfect spin polarization in a large energy region. Moreover, the conductance could be strongly modulated by magnetization of the zigzag edge of AB-stacked BLG, and the junction, entirely made of carbon, produces a giant magnetoresistance (GMR) up to 100%. Intestinally, GMR and spin polarization could be tuned by varying BLG width and length. Generally, MR in a AB-stacked BLG strongly increases (decreases) with length (width).

  7. Vortex dynamics in ferromagnetic/superconducting bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Cieplak, M.Z.; Adamus, Z. [Polish Acad Sci, Inst Phys, PL-02668 Warsaw, (Poland); Konczykowski, M. [CEA, DSM, DRECAM, Lab Solides Irradies, Ecole Polytechnique, CNRS-UMR 7642, F-91128 Palaiseau (France); Zhu, L.Y.; Chien, C.L. [Johns Hopkins Univ, Dept Phys and Astron, Baltimore, MD 21218 (United States)

    2008-07-01

    The dependence of vortex dynamics on the geometry of magnetic domain pattern is studied in the superconducting/ferromagnetic bilayers, in which niobium is a superconductor, and Co/Pt multilayer with perpendicular magnetic anisotropy serves as a ferromagnetic layer. Magnetic domain patterns with different density of domains per surface area and different domain size, w, are obtained for Co/Pt with different thickness of Pt. The dense patterns of domains with the size comparable to the magnetic penetration depth (w {>=} {lambda}) produce large vortex pinning and smooth vortex penetration, while less dense patterns with larger domains (w {>=}{>=} {lambda}) enhance pinning less effectively and result in flux jumps during flux motion. (authors)

  8. Bilayer avalanche spin-diode logic

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Joseph S., E-mail: joseph.friedman@u-psud.fr; Querlioz, Damien [Institut d’Electronique Fondamentale, Univ. Paris-Sud, CNRS, 91405 Orsay (France); Fadel, Eric R. [Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Wessels, Bruce W. [Department of Electrical Engineering & Computer Science, Northwestern University, Evanston, IL 60208 (United States); Department of Materials Science & Engineering, Northwestern University, Evanston, IL 60208 (United States); Sahakian, Alan V. [Department of Electrical Engineering & Computer Science, Northwestern University, Evanston, IL 60208 (United States); Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 (United States)

    2015-11-15

    A novel spintronic computing paradigm is proposed and analyzed in which InSb p-n bilayer avalanche spin-diodes are cascaded to efficiently perform complex logic operations. This spin-diode logic family uses control wires to generate magnetic fields that modulate the resistance of the spin-diodes, and currents through these devices control the resistance of cascaded devices. Electromagnetic simulations are performed to demonstrate the cascading mechanism, and guidelines are provided for the development of this innovative computing technology. This cascading scheme permits compact logic circuits with switching speeds determined by electromagnetic wave propagation rather than electron motion, enabling high-performance spintronic computing.

  9. Computer Simulations of Lipid Bilayers and Proteins

    OpenAIRE

    Sonne, Jacob

    2006-01-01

    Molekyldynamiske (MD) computersimuleringer benyttes i dag i stor ud\\-str{\\ae}k\\-ning til at studere forskellige typer systemer p{\\aa} submikroskopiske l{\\ae}ng\\-de\\-ska\\-laer. I denne afhandling med titlen {\\it Computer simulations of lipid bilayers and proteins} beskrives MD simuleringer af biologiske membraner og proteiner. I en MD simulering l{\\o}\\-ses Newtons be\\-v{\\ae}gel\\-ses\\-lig\\-ning numerisk for en samling af op til nogle hundrede tusinde atomer. Hovedresultatet af en s{\\aa}dan simu...

  10. DNA nanostructures interacting with lipid bilayer membranes.

    Science.gov (United States)

    Langecker, Martin; Arnaut, Vera; List, Jonathan; Simmel, Friedrich C

    2014-06-17

    CONSPECTUS: DNA has been previously shown to be useful as a material for the fabrication of static nanoscale objects, and also for the realization of dynamic molecular devices and machines. In many cases, nucleic acid assemblies directly mimic biological structures, for example, cytoskeletal filaments, enzyme scaffolds, or molecular motors, and many of the applications envisioned for such structures involve the study or imitation of biological processes, and even the interaction with living cells and organisms. An essential feature of biological systems is their elaborate structural organization and compartmentalization, and this most often involves membranous structures that are formed by dynamic assemblies of lipid molecules. Imitation of or interaction with biological systems using the tools of DNA nanotechnology thus ultimately and necessarily also involves interactions with lipid membrane structures, and thus the creation of DNA-lipid hybrid assemblies. Due to their differing chemical nature, however, highly charged nucleic acids and amphiphilic lipids do not seem the best match for the construction of such systems, and in fact they are rarely found in nature. In recent years, however, a large variety of lipid-interacting DNA conjugates were developed, which are now increasingly being applied also for the realization of DNA nanostructures interacting with lipid bilayer membranes. In this Account, we will present the current state of this emerging class of nanosystems. After a brief overview of the basic biophysical and biochemical properties of lipids and lipid bilayer membranes, we will discuss how DNA molecules can interact with lipid membranes through electrostatic interactions or via covalent modification with hydrophobic moieties. We will then show how such DNA-lipid interactions have been utilized for the realization of DNA nanostructures attached to or embedded within lipid bilayer membranes. Under certain conditions, DNA nanostructures remain mobile on

  11. Bilayer avalanche spin-diode logic

    Directory of Open Access Journals (Sweden)

    Joseph S. Friedman

    2015-11-01

    Full Text Available A novel spintronic computing paradigm is proposed and analyzed in which InSb p-n bilayer avalanche spin-diodes are cascaded to efficiently perform complex logic operations. This spin-diode logic family uses control wires to generate magnetic fields that modulate the resistance of the spin-diodes, and currents through these devices control the resistance of cascaded devices. Electromagnetic simulations are performed to demonstrate the cascading mechanism, and guidelines are provided for the development of this innovative computing technology. This cascading scheme permits compact logic circuits with switching speeds determined by electromagnetic wave propagation rather than electron motion, enabling high-performance spintronic computing.

  12. Deformation of giant lipid bilayer vesicles in shear flow

    NARCIS (Netherlands)

    Haas, de K.H.; Blom, C.; Ende, van den D.; Duits, M.H.G.; Mellema, J.

    1997-01-01

    We describe experimental studies of the deformation of giant lipid bilayer vesicles in shear flow. The experiments are carried out with a counterrotating Couette apparatus. The deformation depends on the mechanical properties of the lipid bilayer, the vesicle radius, and the viscosity of the surroun

  13. Tetracycline diffusion through phospholipid bilayers and binding to phospholipids.

    OpenAIRE

    Argast, M; Beck, C.F.

    1984-01-01

    The ability of tetracycline to pass through phospholipid bilayers by diffusion was investigated. Liposomes did not retain enclosed tetracycline. Accumulation of tetracycline was observed with liposomes containing entrapped Tet repressor protein. These results indicate that the drug can pass through lipid bilayers. The antibiotic was also shown to bind to liposomes and isolated phospholipids.

  14. Fluid lipid bilayers: Intermonolayer coupling and its thermodynamic manifestations

    DEFF Research Database (Denmark)

    Hansen, Per Lyngs; Miao, Ling; Ipsen, John Hjorth

    1998-01-01

    A fluid membrane of lipid bilayer consists of two individual molecular monolayers physically opposed to each other. This unique molecular architecture naturally necessitates the need to treat a lipid-bilayer membrane as one entity of two coupled two-dimensional systems (monolayers), each of which...

  15. A NOVEL APPROACH OF BILAYER TABLET TECHNOLOGY: A REVIEW

    Directory of Open Access Journals (Sweden)

    Panchal Hiten Ashok

    2012-05-01

    Full Text Available Over the past 30 years as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. . So use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. Several pharmaceutical companies are currently developing bi-layer tablets. For a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains about different techniques of bilayer tablet and why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, Inaccurate individual layer weight control, cross-contamination between the layers, reduced yield etc.

  16. Regulation of sodium channel function by bilayer elasticity

    DEFF Research Database (Denmark)

    Lundbaek, Jens A; Birn, Pia; Hansen, Anker J;

    2004-01-01

    kinetics of the protein conformational changes therefore will be regulated by the bilayer elasticity, which is determined by the lipid composition. This hydrophobic coupling mechanism has been studied extensively in gramicidin channels, where the channel-bilayer hydrophobic interactions link a...... "conformational" change (the monomerdimer transition) to an elastic bilayer deformation. Gramicidin channels thus are regulated by the lipid bilayer elastic properties (thickness, monolayer equilibrium curvature, and compression and bending moduli). To investigate whether this hydrophobic coupling mechanism could...... be a general mechanism regulating membrane protein function, we examined whether voltage-dependent skeletal-muscle sodium channels, expressed in HEK293 cells, are regulated by bilayer elasticity, as monitored using gramicidin A (gA) channels. Nonphysiological amphiphiles (beta...

  17. Millimeter-area, free standing, phospholipid bilayers.

    Science.gov (United States)

    Beltramo, Peter J; Van Hooghten, Rob; Vermant, Jan

    2016-05-11

    Minimal model biomembrane studies have the potential to unlock the fundamental mechanisms of cellular function that govern the processes upon which life relies. However, existing methods to fabricate free-standing model membranes currently have significant limitations. Bilayer sizes are often tens of micrometers, decoupling curvature or substrate effects, orthogonal control over tension, and solvent exchange combined with microscopy techniques is not possible, which restricts the studies that can be performed. Here, we describe a versatile platform to generate free standing, planar, phospholipid bilayers with millimeter scale areas. The technique relies on an adapted thin-film balance apparatus allowing for the dynamic control of the nucleation and growth of a planar black lipid membrane in the center of an orifice surrounded by microfluidic channels. Success is demonstrated using several different lipid types, including mixtures that show the same temperature dependent phase separation as existing protocols, moreover, membranes are highly stable. Two advantages unique to the proposed method are the dynamic control of the membrane tension and the possibility to make extremely large area membranes. We demonstrate this by showing how a block polymer, F68, used in drug delivery increases the membrane compliance. Together, the results demonstrate a new paradigm for studying the mechanics, structure, and function of model membranes. PMID:27050618

  18. Edge states of zigzag bilayer graphite nanoribbons

    Science.gov (United States)

    Rhim, Jun-Won; Moon, Kyungsun

    2008-09-01

    The electronic structures of zigzag bilayer graphite nanoribbons (Z-BGNRs) with various ribbon widths N are studied within the tight binding approximation. Neglecting the inter-layer hopping amplitude γ4, which is an order of magnitude smaller than the other inter-layer hopping parameters, there exist two fixed Fermi points ± k* independent of the ribbon width with a peculiar energy dispersion near k* as ɛ(k)~ ± (k-k*)N. By investigating the edge states of Z-BGNRs, we notice that the trigonal warping of the bilayer graphene sheets is reflected in the edge state structure. With the inclusion of γ4, the above two Fermi points are not fixed but drift toward the vicinity of the Dirac point with increasing width N, as shown by the finite scaling method, and the peculiar dispersions change to parabolic ones. The edge magnetism of Z-BGNRs is also examined by solving the half-filled Hubbard Hamiltonian for the ribbon using the Hartree-Fock approximation. We have shown that within the same side of the edges, the edge spins are aligned ferromagnetically for the experimentally relevant set of parameters.

  19. Edge states of zigzag bilayer graphite nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Rhim, Jun-Won; Moon, Kyungsun [Department of Physics and Institute of Physics and Applied Physics, Yonsei University, Seoul 120-749 (Korea, Republic of)], E-mail: kmoon@yonsei.ac.kr

    2008-09-10

    The electronic structures of zigzag bilayer graphite nanoribbons (Z-BGNRs) with various ribbon widths N are studied within the tight binding approximation. Neglecting the inter-layer hopping amplitude {gamma}{sub 4}, which is an order of magnitude smaller than the other inter-layer hopping parameters, there exist two fixed Fermi points {+-} k{sup *} independent of the ribbon width with a peculiar energy dispersion near k{sup *} as {epsilon}(k){approx} {+-} (k-k{sup *}){sup N}. By investigating the edge states of Z-BGNRs, we notice that the trigonal warping of the bilayer graphene sheets is reflected in the edge state structure. With the inclusion of {gamma}{sub 4}, the above two Fermi points are not fixed but drift toward the vicinity of the Dirac point with increasing width N, as shown by the finite scaling method, and the peculiar dispersions change to parabolic ones. The edge magnetism of Z-BGNRs is also examined by solving the half-filled Hubbard Hamiltonian for the ribbon using the Hartree-Fock approximation. We have shown that within the same side of the edges, the edge spins are aligned ferromagnetically for the experimentally relevant set of parameters.

  20. Vulnerability of bridges to fire

    DEFF Research Database (Denmark)

    Giuliani, Luisa; Crosti, C.; Gentili, F.

    2012-01-01

    Even if recent effort in developing methodology and measures for design structures against fire and explosions has been mostly focused on buildings, bridges can also be very sensitive to those actions, as witnesses by some recent bridge accidents, which caused major economic losses and also...... endangered people safety in few cases. Purpose of this paper is making a focus on the state of the art of the research and current regulations concerning the response of bridges to fire. Several cases of bridge fires are reported and a focus is made on the occurrence and consequence of bridge fires......, considering both the costs deriving by structural damages and by limited serviceability and other indirect societal aspects. Few cases of recent bridge fire are reviewed in detail and structural consequences are highlighted, distinguishing between damages directly induced by fire and damages induced by local...

  1. Monitoring of concrete bridges

    Czech Academy of Sciences Publication Activity Database

    Pirner, Miroš; Urushadze, Shota

    Orlando,Florida: Society for Experimental Mechanics, Inc, 2007 - (Wicks, A.), s. 250-257 ISBN 0-912053-97-6. [IMAC, Conference & Exposition on Structural Dynamics/25./. Orlando (US), 17.02.2007-19.02.2007] R&D Projects: GA MDS(CZ) 1F45D/013/120; GA ČR(CZ) GA103/05/2066 Institutional research plan: CEZ:AV0Z20710524 Keywords : Long-term measurements * Dynamic response * Bridge * Strain gauges * Rain-flow Subject RIV: JM - Building Engineering

  2. Theory of bridge aerodynamics

    CERN Document Server

    Strømmen, Einar

    2006-01-01

    This text book is intended for studies in wind engineering, with focus on the stochastic theory of wind induced dynamic response calculations for slender bridges or other line ?like civil engineering type of structures. It contains the background assumptions and hypothesis as well as the development of the computational theory that is necessary for the prediction of wind induced fluctuating displacements and cross sectional forces. The simple cases of static and quasi-static structural response calculations are for the sake of completeness also included. The text is at an advanced level in the

  3. Nondestructive testing for bridge diagnosis

    International Nuclear Information System (INIS)

    There are many motivations for bridge diagnosis using Nondestructive testing (NDT) to monitor its integrity. The measured frequency and damping on real bridge are compared in one figure as a function of span length and general aspects are explained. These date were measured in every construction of bridges and applied to design new bridges. Ultrasonic testing is also well used for concrete and steel members mainly to detect internal damages or delaminations. Detail analysis on reflected waves gives us more accurate information about the defect. Experimental results are shown as examples in this paper.

  4. Modelling railway bridge asset management

    OpenAIRE

    Le, Bryant Linh Hai

    2014-01-01

    The UK has a long history in the railway industry with a large number of railway assets. Railway bridges form one of the major asset groups with more than 35,000 bridges. The majority of the bridge population are old being constructed over 100 years ago. Many of the bridges were not designed to meet the current network demand. With an expected increasing rate of deterioration due to the increasing traffic loads and intensities, the management authorities are faced with the difficult task of k...

  5. Environmental life cycle assessment comparison between two bridge types: reinforced concrete bridge and steel composite bridge

    DEFF Research Database (Denmark)

    Du, Guangli; Karoumi, Raid

    2013-01-01

    The concept of sustainable construction has attracted an increased attention. Bridge infrastructures and their belonged construction activities consume considerable material and energy, which is responsible for large environmental burdens. However, the environmental assessment of bridges has not...... been integrated into the decision-making process. This paper presents a systematic LCA method for quantifying the environmental impacts for bridges. The comparison study is performed between a reinforced concrete bridge and a steel bridge as an alternative design, with several key maintenance and EOL...... scenarios outlined. LCA study is performed with the ReCiPe methodology with life cycle inventories data from public database. Five selected mid-point level impact categories and the energy consumption are presented. The result shows that the steel bridge has a better environmental performance due to the...

  6. Fabrication of Supported Lipid Bilayer on Graphene Oxide

    International Nuclear Information System (INIS)

    Planar lipid bilayers of dioleoylphosphatidylcholine was prepared on graphene oxide (GO), as a fundamental platform for biosensing in plasma membrane model using graphene. The GO flakes were prepared according to modified Hummer's method, and deposited on thermally oxidized SiO2/Si surfaces. We found that planar lipid bilayers were reproducibility formed on the GO/SiO2/Si surface in the presence of Ca2+ ions, while unruptured vesicles remained on the GO surface without Ca2+ ion. The results of atomic force microscope observation and fluorescence recovery after photobleaching experiment revealed that double lipid bilayers were spontaneously formed on the GO surfaces.

  7. Shape Changes of Self-Assembled Actin Bilayer Composite Membranes

    CERN Document Server

    Hackl, W; Sackmann, E

    1997-01-01

    We report the self-assembly of thin actin shells beneath the membranes of giant vesicles. Ion-carrier mediated influx of Mg2+ induces actin polymerization in the initially spherical vesicles. Buckling of the vesicles and the formation of blisters after thermally induced bilayer expansion is demonstrated. Bilayer flickering is dominated by tension generated by its coupling to the actin cortex. Quantitative flicker analysis suggests the bilayer and the actin cortex are separated by 0.4 \\mum to 0.5 \\mum due to undulation forces.

  8. A circuit model for defective bilayer graphene transistors

    Science.gov (United States)

    Umoh, Ime J.; Moktadir, Zakaria; Hang, Shuojin; Kazmierski, Tom J.; Mizuta, Hiroshi

    2016-05-01

    This paper investigates the behaviour of a defective single-gate bilayer graphene transistor. Point defects were introduced into pristine graphene crystal structure using a tightly focused helium ion beam. The transfer characteristics of the exposed transistors were measured ex-situ for different defect concentrations. The channel peak resistance increased with increasing defect concentration whilst the on-off ratio showed a decreasing trend for both electrons and holes. To understand the electrical behaviour of the transistors, a circuit model for bilayer graphene is developed which shows a very good agreement when validated against experimental data. The model allowed parameter extraction of bilayer transistor and can be implemented in circuit level simulators.

  9. Fractional quantum Hall states in charge-imbalanced bilayer systems

    OpenAIRE

    Thiebaut, N.; Regnault, N.; Goerbig, M. O.

    2013-01-01

    We study the fractional quantum Hall effect in a bilayer with charge-distribution imbalance induced, for instance, by a bias gate voltage. The bilayer can either be intrinsic or it can be formed spontaneously in wide quantum wells, due to the Coulomb repulsion between electrons. We focus on fractional quantum Hall effect in asymmetric bilayer systems at filling factor nu=4/11 and show that an asymmetric Halperin-like trial wavefunction gives a valid description of the ground state of the system.

  10. Oxygen diffusion in bilayer polymer films

    DEFF Research Database (Denmark)

    Poulsen, Lars; Zebger, Ingo; Tofte, Jannik Pentti;

    2004-01-01

    Experiments to quantify oxygen diffusion have been performed on polymer samples in which a film of poly(ethylene-co-norbornene) was cast onto a film of polystyrene which, in turn, was cast onto an oxygen-impermeable substrate. In the technique employed, the time evolution of oxygen transport...... through the film of poly(ethylene-co-norbornene) and into the polystyrene film was monitored using the phosphorescence of singlet oxygen as a spectroscopic probe. To analyze the data, it was necessary to solve Fick's second law of diffusion for both polymer films. Tractable analytical and numerical...... solutions were obtained for the problem. Moreover, the numerical solution is sufficiently general that it can be used to simulate oxygen concentration profiles in films consisting of more than two layers. Data obtained from the bilayer films yield a diffusion coefficient for oxygen in poly...

  11. Vortex dynamics in ferromagnetic/superconducting bilayers

    International Nuclear Information System (INIS)

    The dependence of vortex dynamics on the geometry of magnetic domain pattern is studied in the superconducting/ferromagnetic bilayers, in which niobium is a superconductor, and Co/Pt multilayer with perpendicular magnetic anisotropy serves as a ferromagnetic layer. Magnetic domain patterns with different density of domains per surface area and different domain size, w, are obtained for Co/Pt with different thickness of Pt. The dense patterns of domains with the size comparable to the magnetic penetration depth (w ≥ λ) produce large vortex pinning and smooth vortex penetration, while less dense patterns with larger domains (w ≥≥ λ) enhance pinning less effectively and result in flux jumps during flux motion. (authors)

  12. Vortex Dynamics in Ferromagnetic/Superconducting Bilayers

    Science.gov (United States)

    Cieplak, M. Z.; Adamus, Z.; Kończykowski, M.; Zhu, L. Y.; Chien, C. L.

    2008-07-01

    The dependence of vortex dynamics on the geometry of magnetic domain pattern is studied in the superconducting/ferromagnetic bilayers, in which niobium is a superconductor, and Co/Pt multilayer with perpendicular magnetic anisotropy serves as a ferrromagnetic layer. Magnetic domain patterns with different density of domains per surface area and different domain size, w, are obtained for Co/Pt with different thickness of Pt. The dense patterns of domains with the size comparable to the magnetic penetration depth (w ≥ qλ) produce large vortex pinning and smooth vortex penetration, while less dense patterns with larger domains (w ≫ λ) enhance pinning less effectively and result in flux jumps during flux motion.

  13. Experimental demonstration of a bilayer thermal cloak.

    Science.gov (United States)

    Han, Tiancheng; Bai, Xue; Gao, Dongliang; Thong, John T L; Li, Baowen; Qiu, Cheng-Wei

    2014-02-01

    Invisibility has attracted intensive research in various communities, e.g., optics, electromagnetics, acoustics, thermodynamics, dc, etc. However, many experimental demonstrations have only been achieved by virtue of simplified approaches due to the inhomogeneous and extreme parameters imposed by the transformation-optic method, and usually require a challenging realization with metamaterials. In this Letter, we demonstrate a bilayer thermal cloak made of bulk isotropic materials, and it has been validated as an exact cloak. We experimentally verified its ability to maintain the heat front and its heat protection capabilities in a 2D proof-of-concept experiment. The robustness of this scheme is validated in both 2D (including oblique heat front incidence) and 3D configurations. The proposed scheme may open a new avenue to control the diffusive heat flow in ways inconceivable with phonons, and also inspire new alternatives to the functionalities promised by transformation optics. PMID:24580600

  14. Population inversion in monolayer and bilayer graphene

    International Nuclear Information System (INIS)

    The recent demonstration of saturable absorption and negative optical conductivity in the Terahertz range in graphene has opened up new opportunities for optoelectronic applications based on this and other low dimensional materials. Recently, population inversion across the Dirac point has been observed directly by time- and angle-resolved photoemission spectroscopy (tr-ARPES), revealing a relaxation time of only ∼130 femtoseconds. This severely limits the applicability of single layer graphene to, for example, Terahertz light amplification. Here we use tr-ARPES to demonstrate long-lived population inversion in bilayer graphene. The effect is attributed to the small band gap found in this compound. We propose a microscopic model for these observations and speculate that an enhancement of both the pump photon energy and the pump fluence may further increase this lifetime. (paper)

  15. Thermal bridges of modern windows

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker;

    2013-01-01

    With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even if the wi...

  16. Vulnerability of bridges to fire

    DEFF Research Database (Denmark)

    Giuliani, Luisa; Crosti, C.; Gentili, F.

    2012-01-01

    Even if recent effort in developing methodology and measures for design structures against fire and explosions has been mostly focused on buildings, bridges can also be very sensitive to those actions, as witnesses by some recent bridge accidents, which caused major economic losses and also endan...

  17. Superconductivity in small metal bridges

    International Nuclear Information System (INIS)

    Josephson effects in weaklinks are discussed for low and high frequency regimes using simple perturbation techniques. It is proven that no measurement of the supercurrent dependence upon frequency above the Riedel peak frequency can be made using rf sources whose frequencies are below the Riedel peak. Thus the bulk of work done in the field on the high frequency structure of the Josephson current is shown to be invalid. Metal bridges shorter than a newly defined temperature independent length for superconductors, l/sub PHONON/, are proven to be identical in their Josephson current behavior to tunneling junctions. The BCS gap equation is generalized to include voltage gradient effects on pairs within the bridge. The oscillation frequency for long bridges (l/sub BRIDGE/ greater than l/sub PHONON/) is shown to be limited to less than 10'' Hz. An experimental test of the new voltage dependent gap is made as well as tests of the pair reforming time of bridges

  18. Bridge Coupler for APT

    CERN Document Server

    Greninger, P T; Spalek, G; Greninger, Paul T.; Rodarte, Henry J.

    2000-01-01

    The Coupled Cavity Drift Tube Linac (CCDTL) used in the Accelerator for the Production of Tritium (APT) is fully described elsewhere [1]. The modules are composed of several machined and brazed segments that must account for the accumulation of dimensional tolerances in the build up of the stack. In addition, space requirements dictate that power fed to the accelerator cannot be through the accelerating cavities. As well, we would like to remove a single segment of the accelerator without removing additional segments. These requirements combined with phasing relationships of the design and space limitations have resulted in a different bridge coupling method used in the module comprising 3-gap segments. The coupling method, phasing relationships and other features that enhance the flexibility of the design will be discussed.

  19. Half Bridge Inductive Heater

    Directory of Open Access Journals (Sweden)

    Zoltán GERMÁN-SALLÓ

    2015-12-01

    Full Text Available Induction heating performs contactless, efficient and fast heating of conductive materials, therefore became one of the preferred heating procedure in industrial, domestic and medical applications. During induction heating the high-frequency alternating currents that heat the material are induced by means of electromagnetic induction. The material to be heated is placed inside the time-varying magnetic field generated by applying a highfrequency alternating current to an induction coil. The alternating electromagnetic field induces eddy currents in the workpiece, resulting resistive losses, which then heat the material. This paper describes the design of a power electronic converter circuit for induction heating equipment and presents the obtained results. The realized circuit is a low power half bridge resonant inverter which uses power MOS transistors and adequate driver circuits.

  20. Nanoparticle bridge DNA biosensor

    Science.gov (United States)

    Huang, Hong-Wen

    A new DNA sensing method is demonstrated in which DNA hybridization events lead to the formation of nanoparticle satellites that bridge two electrodes and are detected electrically. The hybridization events are exclusively carried out only on specific locations, the surfaces of C-ssDNA modified 50 nm GNPs. The uniqueness of this work is that only a small number of T-ccDNA molecules (target DNA and three-base-pair-mismatched DNA in 20nM concentrations. Three single-stranded DNA (ssDNA) system is used in our experiment which includes Capture-ssDNA (C-ssDNA), Target-ssDNA (T-ssDNA) and Probe-ssDNA (P-ssDNA). Both C-ssDNA and P-ssDNA are modified by a thiol group and can hybridize with different portions of T-ssDNA. T-ssDNA requires no modification in three ssDNA system, which is beneficial in many applications. C-ssDNA modified 50nm gold nanoparticle (C-50au) and P-ssDNA modified 30nm gold nanoparticle (P-30au) are prepared through the reaction of thiol-gold chemical bonding between thiolated ssDNA and gold nanoparticle (GNP) (C-ssDNA with 50nm GNP, P-ssDNA with 30nm GNP). We controllably place the C-50au only on the SiO2 band surface (˜ 90nm width) between two gold electrodes (source and drain electrodes) by forming positively- and negatively-charged self-assembled monolayers (SAMs) on SiO2 and gold surface, respectively. DNA modified GNP is negatively charged due to ionization of phosphate group on DNA back bone. C-50au therefore is negatively charged and can only be attracted toward SiO2 area (repelled by negatively charged gold electrode surface). The amine group of positively-charged SAMs on SiO2 surface is then passivated by converting to non-polar methyl functional group after C-50au placement. P-30au is first hybridized with T-ssDNA in the solution phase (T-P- 30au formed) and is introduced into DNA detection device in which C-50au are immobilized on ˜90nm width SiO2 band (between two gold electrodes). The passivation step ensures every TP-30au are attached

  1. Electronic properties of asymmetrically doped twisted graphene bilayers

    Science.gov (United States)

    Trambly de Laissardière, Guy; Namarvar, Omid Faizy; Mayou, Didier; Magaud, Laurence

    2016-06-01

    Rotated graphene bilayers form an exotic class of nanomaterials with fascinating electronic properties governed by the rotation angle θ . For large rotation angles, the electron eigenstates are restricted to one layer and the bilayer behaves like two decoupled graphene layers. At intermediate angles, Dirac cones are preserved but with a lower velocity and van Hove singularities are induced at energies where the two Dirac cones intersect. At very small angles, eigenstates become localized in peculiar moiré zones. We analyze here the effect of an asymmetric doping for a series of commensurate rotated bilayers on the basis of tight-binding calculations of their band dispersions, density of states, participation ratio, and diffusive properties. While a small doping level preserves the θ dependence of the rotated bilayer electronic structure, larger doping induces a further reduction of the band velocity in the same way as a further reduction of the rotation angle.

  2. Tethered and Polymer Supported Bilayer Lipid Membranes: Structure and Function

    Directory of Open Access Journals (Sweden)

    Jakob Andersson

    2016-05-01

    Full Text Available Solid supported bilayer lipid membranes are model systems to mimic natural cell membranes in order to understand structural and functional properties of such systems. The use of a model system allows for the use of a wide variety of analytical tools including atomic force microscopy, impedance spectroscopy, neutron reflectometry, and surface plasmon resonance spectroscopy. Among the large number of different types of model membranes polymer-supported and tethered lipid bilayers have been shown to be versatile and useful systems. Both systems consist of a lipid bilayer, which is de-coupled from an underlying support by a spacer cushion. Both systems will be reviewed, with an emphasis on the effect that the spacer moiety has on the bilayer properties.

  3. Capacitance Variation of Electrolyte-Gated Bilayer Graphene Based Transistors

    Directory of Open Access Journals (Sweden)

    Hediyeh Karimi

    2013-01-01

    Full Text Available Quantum capacitance of electrolyte-gated bilayer graphene field-effect transistors is investigated in this paper. Bilayer graphene has received huge attention due to the fact that an energy gap could be opened by chemical doping or by applying external perpendicular electric field. So, this extraordinary property can be exploited to use bilayer graphene as a channel in electrolyte-gated field-effect transistors. The quantum capacitance of bi-layer graphene with an equivalent circuit is presented, and also based on the analytical model a numerical solution is reported. We begin by modeling the DOS, followed by carrier concentration as a function V in degenerate and nondegenerate regimes. To further confirm this viewpoint, the presented analytical model is compared with experimental data, and acceptable agreement is reported.

  4. Fluorination of Isotopically Labeled Turbostratic and Bernal Stacked Bilayer Graphene

    Czech Academy of Sciences Publication Activity Database

    Ek Weis, Johan; da Costa, Sara; Frank, Otakar; Bastl, Zdeněk; Kalbáč, Martin

    2015-01-01

    Roč. 21, č. 3 (2015), s. 1081-1087. ISSN 1521-3765 R&D Projects: GA MŠk LL1301 Institutional support: RVO:61388955 Keywords : fluorination * graphene * bilayers Subject RIV: CF - Physical ; Theoretical Chemistry

  5. Sub-wavelength antenna enhanced bilayer graphene tunable photodetector

    Energy Technology Data Exchange (ETDEWEB)

    Beechem, III, Thomas Edwin; Howell, Stephen W.; Peters, David W.; Davids, Paul; Ohta, Taisuke

    2016-03-22

    The integration of bilayer graphene with an absorption enhancing sub-wavelength antenna provides an infrared photodetector capable of real-time spectral tuning without filters at nanosecond timescales.

  6. Pairing of cholesterol with oxidized phospholipid species in lipid bilayers

    DEFF Research Database (Denmark)

    Khandelia, Himanshu; Loubet, Bastien; Olzynska, Agnieszka;

    2014-01-01

    We claim that (1) cholesterol protects bilayers from disruption caused by lipid oxidation by sequestering conical shaped oxidized lipid species such as 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PZPC) away from phospholipid, because cholesterol and the oxidized lipid have complementary...... shapes and (2) mixtures of cholesterol and oxidized lipids can self-assemble into bilayers much like lysolipid–cholesterol mixtures. The evidence for bilayer protection comes from molecular dynamics (MD) simulations and dynamic light scattering (DLS) measurements. Unimodal size distributions of extruded...... vesicles (LUVETs) made up of a mixture of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and PZPC containing high amounts of PZPC are only obtained when cholesterol is present in high concentrations. In simulations, bilayers containing high amounts of PZPC become porous, unless cholesterol is also present...

  7. Energy levels of hybrid monolayer-bilayer graphene quantum dots

    Science.gov (United States)

    Mirzakhani, M.; Zarenia, M.; Ketabi, S. A.; da Costa, D. R.; Peeters, F. M.

    2016-04-01

    Often real samples of graphene consist of islands of both monolayer and bilayer graphene. Bound states in such hybrid quantum dots are investigated for (i) a circular single-layer graphene quantum dot surrounded by an infinite bilayer graphene sheet and (ii) a circular bilayer graphene quantum dot surrounded by an infinite single-layer graphene. Using the continuum model and applying zigzag boundary conditions at the single-layer-bilayer graphene interface, we obtain analytical results for the energy levels and the corresponding wave spinors. Their dependence on perpendicular magnetic and electric fields are studied for both types of quantum dots. The energy levels exhibit characteristics of interface states, and we find anticrossings and closing of the energy gap in the presence of a bias potential.

  8. Effect of impurity doping in gapped bilayer graphene

    International Nuclear Information System (INIS)

    Impurity doping plays a pivotal role in semiconductor electronics. We study the doping effect in a two-dimensional semiconductor, gapped bilayer graphene. By employing in situ deposition of calcium on the bilayer graphene, dopants are controllably introduced. Low temperature transport results show a variable range hopping conduction near the charge neutrality point persisting up to 50 K, providing evidence for the impurity levels inside the gap. Our experiment confirms a predicted peculiar effect in the gapped bilayer graphene, i.e., formation of in-gap states even if the bare impurity level lies in the conduction band. The result provides perspective on the effect of doping and impurity levels in semiconducting bilayer graphene

  9. Thermal stability of Mo/Au bilayers for TES applications

    International Nuclear Information System (INIS)

    Mo/Au bilayers are among the most suitable materials to be used as transition-edge sensors (TES) in cryogenic microcalorimeters and bolometers, developed, among other fields, for space missions. For this purpose the thermal stability of TES at temperatures below 150 °C is a critical issue. We report on the dependence of functional properties (superconducting critical temperature, residual resistance and α) as well as on microstructure, chemical composition and interface quality for optimized high quality Mo/Au bilayers on annealing temperature and time. Data show that the functional properties of the bilayers remain stable at T C at T ≥ 200 °C are mainly due to an increase in the average Au grain size and to Au migration along the Mo grain boundaries at the Au/Mo interface. A way to stabilize the functional properties of the Mo/Au bilayers against temperature enhancements is proposed. (paper)

  10. Influence of trigonal warping on interference effects in bilayer graphene

    OpenAIRE

    Kechedzhi, K.; Falko, Vladimir I; McCann, E.; Altshuler, B.L.

    2007-01-01

    Bilayer graphene (two coupled graphitic monolayers arranged according to Bernal stacking) is a two-dimensional gapless semiconductor with a peculiar electronic spectrum different from the Dirac spectrum in the monolayer material. In particular, the electronic Fermi line in each of its valleys has a strong p -> -p asymmetry due to a trigonal warping, which suppresses the weak localization effect. We show that weak localisation in bilayer graphene may be present only in devices with pronounced ...

  11. Deformation of giant lipid bilayer vesicles in shear flow

    OpenAIRE

    Haas,; Blom, C.; Ende, van den, D.; Duits, M. H. G.; Mellema, J.

    1997-01-01

    We describe experimental studies of the deformation of giant lipid bilayer vesicles in shear flow. The experiments are carried out with a counterrotating Couette apparatus. The deformation depends on the mechanical properties of the lipid bilayer, the vesicle radius, and the viscosity of the surrounding Newtonian liquid. We show that the relevant mechanical parameter is the bending rigidity. A simple model has been developed that describes the deformation of a vesicle. This model takes therma...

  12. Atomistic Simulations of Pore Formation and Closure in Lipid Bilayers

    OpenAIRE

    Bennett, W. F. Drew; Sapay, Nicolas; Tieleman, D. Peter

    2014-01-01

    Cellular membranes separate distinct aqueous compartments, but can be breached by transient hydrophilic pores. A large energetic cost prevents pore formation, which is largely dependent on the composition and structure of the lipid bilayer. The softness of bilayers and the disordered structure of pores make their characterization difficult. We use molecular-dynamics simulations with atomistic detail to study the thermodynamics, kinetics, and mechanism of pore formation and closure in DLPC, DM...

  13. Constant helical pitch of the gramicidin channel in phospholipid bilayers.

    OpenAIRE

    Katsaras, J.; Prosser, R S; Stinson, R H; Davis, J H

    1992-01-01

    X-ray diffraction has been applied in measuring the helical pitch of the gramicidin channel in oriented bilayers of dilauroylphosphatidylcholine (DLPC) and dimyristoylphosphatidylcholine (DMPC) at a polypeptide concentration of 9.1 mol %. The diffraction data show the helical pitch of gramicidin to be 4.7 +/- 0.2 A in both gel and liquid-crystalline phase bilayers, with and without monovalent cations. In addition, the width of the reflection due to the pitch of the helical gramicidin channel ...

  14. Polysaccharide-supported planar bilayer lipid model membranes

    OpenAIRE

    Baumgart, T.; Offenhäusser, A.

    2003-01-01

    Bilayer lipid membranes were deposited onto two different thin water swellable polymer cushions predominantly by Langmuir-Blodgett trough methods. Membranes consisting of zwitterionic lipids supported by agarose films were shown to be unstable, as observed by fluorescence microscopy, reflection interference contrast microscopy, and the impossibility of bilayer spreading (Radler, J.; Strey, H.; Sackmann, E. Langmuir 1995, 11, 4539-4548) on the agarose surface. Chitosan, formerly observed to pe...

  15. Dynamics and instabilities of lipid bilayer membrane shapes

    OpenAIRE

    Shi, Zheng; Baumgart, Tobias

    2014-01-01

    Biological membranes undergo constant shape remodeling involving the formation of highly curved structures. The lipid bilayer represents the fundamental architecture of the cellular membrane with its shapes determined by the Helfrich curvature bending energy. However, the dynamics of bilayer shape transitions, especially their modulation by membrane proteins, and the resulting shape instabilities, are still not well understood. Here, we review in a unifying manner several theories that descri...

  16. Molecular Dynamics of a Water-Lipid Bilayer Interface

    Science.gov (United States)

    Wilson, Michael A.; Pohorille, Andrew

    1994-01-01

    We present results of molecular dynamics simulations of a glycerol 1-monooleate bilayer in water. The total length of analyzed trajectories is 5ns. The calculated width of the bilayer agrees well with the experimentally measured value. The interior of the membrane is in a highly disordered fluid state. Atomic density profile, orientational and conformational distribution functions, and order parameters indicate that disorder increases toward the center of the bilayer. Analysis of out-of-plane thermal fluctuations of the bilayer surfaces occurring at the time scale of the present calculations reveals that the distribution of modes agrees with predictions of the capillary wave model. Fluctuations of both bilayer surfaces are uncorrelated, yielding Gaussian distribution of instantaneous widths of the membrane. Fluctuations of the width produce transient thinning defects in the bilayer which occasionally span almost half of the membrane. The leading mechanism of these fluctuations is the orientational and conformational motion of head groups rather than vertical motion of the whole molecules. Water considerably penetrates the head group region of the bilayer but not its hydrocarbon core. The total net excess dipole moment of the interfacial water points toward the aqueous phase, but the water polarization profile is non-monotonic. Both water and head groups significantly contribute to the surface potential across the interface. The calculated sign of the surface potential is in agreement with that from experimental measurements, but the value is markedly overestimated. The structural and electrical properties of the water-bilayer system are discussed in relation to membrane functions, in particular transport of ions and nonelectrolytes across membranes.

  17. Edge State and Intrinsic Hole Doping in Bilayer Phosphorene

    OpenAIRE

    Osada, Toshihito

    2014-01-01

    Using a simple LCAO model by Harrison, we have qualitatively studied the edge state of bilayer phosphorene, which is a unit structure of the layered crystal of black phosphorus. This model successfully reproduces the isolated edge state in the bulk gap in monolayer phosphorene. In bilayer phosphorene, however, it shows that edge states are almost buried in the valence band and there is no isolated midgap edge state at the zigzag edge. Since the buried edge state works as acceptor, holes are d...

  18. Modeling constrained sintering of bi-layered tubular structures

    DEFF Research Database (Denmark)

    Tadesse Molla, Tesfaye; Kothanda Ramachandran, Dhavanesan; Ni, De Wei; Esposito, Vincenzo; Teocoli, Francesca; Olevsky, Eugene A.; Bjørk, Rasmus; Pryds, Nini; Kaiser, Andreas; Frandsen, Henrik Lund

    2015-01-01

    densification and stress developments during sintering of tubular bi-layered samples. The correspondence between linear elastic and linear viscous theories is used as a basis for derivation of the model. The developed model is first verified by finite element simulation for sintering of tubular bi-layer system...... thermo-mechanical analysis. Results from the analytical model are found to agree well with finite element simulations as well as measurements from sintering experiment....

  19. The edge engineering of topological Bi(111) bilayer

    OpenAIRE

    Li, Xiao; Liu, Hai-Wen; Jiang, Hua; Wang, Fa; Feng, Ji

    2014-01-01

    A topological insulator is a novel quantum state, characterized by symmetry-protected non-trivial edge/surface states. Our first-principle simulations show the significant effects of the chemical decoration on edge states of topological Bi(111) bilayer nanoribbon, which remove the trivial edge state and recover the Dirac linear dispersion of topological edge state. By comparing the edge states with and without chemical decoration, the Bi(111) bilayer nanoribbon offers a simple system for asse...

  20. Robustly Engineering Thermal Conductivity of Bilayer Graphene by Interlayer Bonding

    Science.gov (United States)

    Zhang, Xiaoliang; Gao, Yufei; Chen, Yuli; Hu, Ming

    2016-01-01

    Graphene and its bilayer structure are the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. Their realistic applications in emerging nanoelectronics usually call for thermal transport manipulation in a controllable and precise manner. In this paper we systematically studied the effect of interlayer covalent bonding, in particular different interlay bonding arrangement, on the thermal conductivity of bilayer graphene using equilibrium molecular dynamics simulations. It is revealed that, the thermal conductivity of randomly bonded bilayer graphene decreases monotonically with the increase of interlayer bonding density, however, for the regularly bonded bilayer graphene structure the thermal conductivity possesses unexpectedly non-monotonic dependence on the interlayer bonding density. The results suggest that the thermal conductivity of bilayer graphene depends not only on the interlayer bonding density, but also on the detailed topological configuration of the interlayer bonding. The underlying mechanism for this abnormal phenomenon is identified by means of phonon spectral energy density, participation ratio and mode weight factor analysis. The large tunability of thermal conductivity of bilayer graphene through rational interlayer bonding arrangement paves the way to achieve other desired properties for potential nanoelectronics applications involving graphene layers. PMID:26911859

  1. Predicting proton titration in cationic micelle and bilayer environments

    Energy Technology Data Exchange (ETDEWEB)

    Morrow, Brian H.; Shen, Jana K. [Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland 21201 (United States); Eike, David M.; Murch, Bruce P.; Koenig, Peter H. [Computational Chemistry, Modeling and Simulation GCO, Procter and Gamble, Cincinnati, Ohio 45201 (United States)

    2014-08-28

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pK{sub a}’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pK{sub a} of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and liquid as well as gel-phase bilayers of diethyl ester dimethylammonium chloride. Interestingly, the pK{sub a} of the fatty acid in the gel bilayer is 5.4, 0.4 units lower than that in the analogous liquid bilayer or micelle, despite the fact that the protonated carboxylic group is significantly more desolvated in the gel bilayer. This work illustrates the capability of all-atom constant pH molecular dynamics in capturing the delicate balance in the free energies of desolvation and Coulombic interactions. It also shows the importance of the explicit treatment of ions in sampling the protonation states. The ability to model dynamics of pH-responsive substrates in a bilayer environment is useful for improving fabric care products as well as our understanding of the side effects of anti-inflammatory drugs.

  2. Robustly Engineering Thermal Conductivity of Bilayer Graphene by Interlayer Bonding

    Science.gov (United States)

    Zhang, Xiaoliang; Gao, Yufei; Chen, Yuli; Hu, Ming

    2016-02-01

    Graphene and its bilayer structure are the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. Their realistic applications in emerging nanoelectronics usually call for thermal transport manipulation in a controllable and precise manner. In this paper we systematically studied the effect of interlayer covalent bonding, in particular different interlay bonding arrangement, on the thermal conductivity of bilayer graphene using equilibrium molecular dynamics simulations. It is revealed that, the thermal conductivity of randomly bonded bilayer graphene decreases monotonically with the increase of interlayer bonding density, however, for the regularly bonded bilayer graphene structure the thermal conductivity possesses unexpectedly non-monotonic dependence on the interlayer bonding density. The results suggest that the thermal conductivity of bilayer graphene depends not only on the interlayer bonding density, but also on the detailed topological configuration of the interlayer bonding. The underlying mechanism for this abnormal phenomenon is identified by means of phonon spectral energy density, participation ratio and mode weight factor analysis. The large tunability of thermal conductivity of bilayer graphene through rational interlayer bonding arrangement paves the way to achieve other desired properties for potential nanoelectronics applications involving graphene layers.

  3. Mechanism of unassisted ion transport across membrane bilayers

    Science.gov (United States)

    Wilson, M. A.; Pohorille, A.

    1996-01-01

    To establish how charged species move from water to the nonpolar membrane interior and to determine the energetic and structural effects accompanying this process, we performed molecular dynamics simulations of the transport of Na+ and Cl- across a lipid bilayer located between two water lamellae. The total length of molecular dynamics trajectories generated for each ion was 10 ns. Our simulations demonstrate that permeation of ions into the membrane is accompanied by the formation of deep, asymmetric thinning defects in the bilayer, whereby polar lipid head groups and water penetrate the nonpolar membrane interior. Once the ion crosses the midplane of the bilayer the deformation "switches sides"; the initial defect slowly relaxes, and a defect forms in the outgoing side of the bilayer. As a result, the ion remains well solvated during the process; the total number of oxygen atoms from water and lipid head groups in the first solvation shell remains constant. A similar membrane deformation is formed when the ion is instantaneously inserted into the interior of the bilayer. The formation of defects considerably lowers the free energy barrier to transfer of the ion across the bilayer and, consequently, increases the permeabilities of the membrane to ions, compared to the rigid, planar structure, by approximately 14 orders of magnitude. Our results have implications for drug delivery using liposomes and peptide insertion into membranes.

  4. Predicting proton titration in cationic micelle and bilayer environments

    International Nuclear Information System (INIS)

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pKa’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pKa of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and liquid as well as gel-phase bilayers of diethyl ester dimethylammonium chloride. Interestingly, the pKa of the fatty acid in the gel bilayer is 5.4, 0.4 units lower than that in the analogous liquid bilayer or micelle, despite the fact that the protonated carboxylic group is significantly more desolvated in the gel bilayer. This work illustrates the capability of all-atom constant pH molecular dynamics in capturing the delicate balance in the free energies of desolvation and Coulombic interactions. It also shows the importance of the explicit treatment of ions in sampling the protonation states. The ability to model dynamics of pH-responsive substrates in a bilayer environment is useful for improving fabric care products as well as our understanding of the side effects of anti-inflammatory drugs

  5. Microporous device for local electric recordings on model lipid bilayers

    International Nuclear Information System (INIS)

    A powerful approach for characterizing lipid membranes and embedded proteins is the reconstitution of model lipid bilayers. The extreme fragility of 5 nm thick bilayers is a challenge for device design and requires a trade off of stability against accessibility. We here present a microporous lab-on-chip device that allows us to form stable, solvent-free lipid bilayers from giant unilamellar vesicles (GUVs) in a geometry that provides a unique set of access possibilities. The device is constructed around a micro-fabricated silicon chip with clusters of 1 µm-diameter pores and provides optical access to the lipid bilayers for high-NA epifluorescence imaging. At the same time, solvent exchange is possible on both sides of the lipid bilayer. Complete coverage can be achieved with GUVs, so that voltages can be applied across the lipid bilayer and single-channel currents can be measured using external or integrated silver/silver chloride electrodes. We describe the micro-fabrication by standard cleanroom techniques and the characterization of the device by atomic force microscopy, scanning electron microscopy and impedance spectroscopy. In proof-of-concept experiments we demonstrate that the device is capable of low-noise, single-ion-channel recordings. (paper)

  6. Formation of supported lipid bilayers by vesicle fusion

    DEFF Research Database (Denmark)

    Lind, Tania Kjellerup; Cardenas Gomez, Marite; Wacklin, Hanna

    2014-01-01

    We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main p...... observed during the deposition process by QCM-D correspond to vesicles absorbed on top of a continuous bilayer and not to a surface-supported vesicular layer as previously reported. © 2014 American Chemical Society.......We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main...... phase-transition temperature of the lipid. We have carefully studied the formation mechanism of supported DPPC bilayers below and above the lipid melting temperature (Tm) by quartz crystal microbalance and atomic force microscopy under continuous flow conditions. We also measured the structure of lipid...

  7. Liquid-Bridge Breaking Limits

    Science.gov (United States)

    Macner, Ashley; Steen, Paul

    2011-11-01

    Wet adhesion by liquid bridges in large arrays shows promise for use in lightweight, controllable on-demand devices. Applications include grab/release of wafer substrates, transport of micron-sized tiles for use in 3D printing and micro-dosing of personalized pharmaceutical drugs. By wetting and spreading, a drop can form a bridge and thereby ``grab'' a nearby solid substrate. By volume decrease or extension, the bridge can break. The breaking limit corresponds to bridge instability which can be predicted, knowing the static mechanical response of the bridge. Mechanical behaviors include force-volume (FV), pressure-volume (pV) and force-length (FL) responses. Instability crucially depends on the mode of failure - failure under constant-force or constant length are typical cases. We study single bridge equilibria for their breaking limits. FV diagrams for the pin-pin equal and pin-pin unequal radii boundary conditions for different bridge heights are measured in the laboratory. The FL response in the case of pin-pin equal radii is also measured. Results are compared to predictions of static theory. Static results are then used to compare to dynamical sequences where volume is driven quasistatically by syringe or an electro-osmotic pump. As the breaking limit is approached, the shape deformation accelerates leading to non-equilibrium shapes not captured by the static analysis.

  8. Bridge Creek IMW database - Bridge Creek Restoration and Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The incised and degraded habitat of Bridge Creek is thought to be limiting a population of ESA-listed steelhead (Oncorhynchus mykiss). A logical restoration...

  9. National Bridge Inventory - National Geospatial Data Asset (NGDA) Bridges

    Data.gov (United States)

    Department of Transportation — The NBI (NTAD 2015) is a collection of information (database) describing the more than 610,000 of the Nation's bridges located on public roads, including Interstate...

  10. General hydrophobic interaction potential for surfactant/lipid bilayers from direct force measurements between light-modulated bilayers

    OpenAIRE

    Donaldson, Stephen H., Jr.; Lee, C. Ted; Chmelka, Bradley F.; Israelachvili, Jacob N.

    2011-01-01

    We establish and quantify correlations among the molecular structures, interaction forces, and physical processes associated with light-responsive self-assembled surfactant monolayers or bilayers at interfaces. Using the surface forces apparatus (SFA), the interaction forces between adsorbed monolayers and bilayers of an azobenzene-functionalized surfactant can be drastically and controllably altered by light-induced conversion of trans and cis molecular conformations. These reversible confor...

  11. Reliability Assessment of Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Middleton, C. R.

    This paper is partly based on research performed for the Highways Agency, London, UK under the project DPU/9/44 "Revision of Bridge Assessment Rules Based on Whole Life Performance: concrete bridges". It contains the details of a methodology which can be used to generate Whole Life (WL) reliability...... profiles. These WL reliability profiles may be used to establish revised rules for concrete bridges. This paper is to some extend based on Thoft-Christensen et. al. [1996], Thoft-Christensen [1996] et. al. and Thoft-Christensen [1996]....

  12. Bridging the urological divide.

    Science.gov (United States)

    Roberts, Robin

    2011-09-23

    The advanced disease clinical presentations, higher morbidity and mortality rates and lack of available treatment options in prostate cancer care, attest to disparities in the delivery and outcomes of urological services in Black men of African lineage in both the Developed and Developing countries. This gap in health care and services in the global management of prostate cancer denotes the urological divide.Through the experience of a Developing country urologist with a comparative literature review, this presentation defines the determinants of the disparity through deficiencies in human, material and financial resources, as is most prevalent in Developing countries.Solutions to ending health care disparities must take into account the existing development phase of Third World countries and thus determine whether the Developed countries should export a total service delivery system or seek primarily to advance the competence and skills of the existing Developing country resources.Collaboration in prostate cancer research has the greatest promise and sustainability of bridging this urological divide and is of mutual benefit to both entities. PMID:21992183

  13. Magnetic Irreversibility in VO2/Ni Bilayers

    Science.gov (United States)

    de La Venta, Jose; Lauzier, Josh; Sutton, Logan

    The temperature dependence of the coercivity and magnetization of VO2/Ni bilayers was studied. VO2 exhibits a well-known Structural Phase Transition (SPT) at 330-340 K, from a low temperature monoclinic (M) to a high temperature rutile (R) structure. The SPT of VO2 induces an inverse magnetoelastic effect that strongly modifies the coercivity and magnetization of the Ni films. In addition, the growth conditions allow tuning of the magnetic properties. Ni films deposited on top of VO2 (M) show an irreversible change in the coercivity after the first cycle through the high temperature phase, with a corresponding change in the surface morphology of VO2. On the other hand, the Ni films grown on top of VO2 (R) do not show this irreversibility. These results indicate that properties of magnetic films are strongly affected by the strain induced by materials that undergo SPT and that it is possible to control the magnetic properties by tuning the growth conditions.

  14. Properties of bilayer contacts to porous silicon

    Science.gov (United States)

    Gallach, D.; Torres-Costa, V.; García-Pelayo, L.; Climent-Font, A.; Martín-Palma, R. J.; Barreiros-das-Santos, M.; Sporer, C.; Samitier, J.; Manso, M.

    2012-05-01

    The aim of the present work is the growth by PVD techniques and ulterior characterization of electrical contacts to columnar porous silicon (PSi) as an approach to reliable PSi sensor devices. Contacts consist of a NiCr (40:60) and Au bilayer on the PSi surface deposited by magnetron sputtering. These structures show a good adhesion to the rough surface of columnar PSi. The morphology of these electrical contacts is characterized by electron microscopy and their crystalline structure by X-ray diffraction. Compositional profiles are determined by Rutherford backscattering spectroscopy and energy dispersive X-ray spectroscopy, which demonstrate that the infiltration of NiCr into the PSi is at the origin of the metallic thin film adhesion improvement. I- V characteristics and impedance spectroscopy measurements show that this configuration provides rectifying electrical contacts to PSi, for which a simple equivalent circuit based on one resistor and two capacitors can be modeled. These results further support the use of PSi electrical structures for sensing purposes.

  15. Properties of bilayer contacts to porous silicon

    Energy Technology Data Exchange (ETDEWEB)

    Gallach, D.; Torres-Costa, V.; Garcia-Pelayo, L.; Climent-Font, A.; Martin-Palma, R.J.; Manso, M. [Universidad Autonoma de Madrid, Departamento de Fisica Aplicada, Madrid (Spain); Barreiros-das-Santos, M.; Sporer, C.; Samitier, J. [Institute for Bioengineering of Catalonia (IBEC), Nanobioengineering Group, Barcelona (Spain)

    2012-05-15

    The aim of the present work is the growth by PVD techniques and ulterior characterization of electrical contacts to columnar porous silicon (PSi) as an approach to reliable PSi sensor devices. Contacts consist of a NiCr (40:60) and Au bilayer on the PSi surface deposited by magnetron sputtering. These structures show a good adhesion to the rough surface of columnar PSi. The morphology of these electrical contacts is characterized by electron microscopy and their crystalline structure by X-ray diffraction. Compositional profiles are determined by Rutherford backscattering spectroscopy and energy dispersive X-ray spectroscopy, which demonstrate that the infiltration of NiCr into the PSi is at the origin of the metallic thin film adhesion improvement. I-V characteristics and impedance spectroscopy measurements show that this configuration provides rectifying electrical contacts to PSi, for which a simple equivalent circuit based on one resistor and two capacitors can be modeled. These results further support the use of PSi electrical structures for sensing purposes. (orig.)

  16. Condensation energy of the superconducting bilayer cuprates

    Indian Academy of Sciences (India)

    Govind; Ajay; S K Joshi

    2002-05-01

    In the present work, we report the interplay of single particle and Cooper pair tunnelings on the superconducting state of layered high-c cuprate superconductors. For this we have considered a model Hamiltonian incorporating the intra-planar interactions and the contributions arising due to the coupling between the planes. The interplanar interactions include the single particle tunneling as well as the Josephson tunneling of Cooper pairs between the two layers. The expression of the out-of-plane correlation parameter which describes the hopping of a particle from one layer to another layer in the superconducting state is obtained within a Bardeen–Cooper–Schriefer (BCS) formalism using the Green’s function technique. This correlation is found to be sensitive to the various parameter of the model Hamiltonian. We have calculated the out-of-plane contribution to the superconducting condensation energy. The calculated values of condensation energy are in agreement with those obtained from the specific heat and the -axis penetration depth measurements on bilayer cuprates.

  17. Detection of bilayer lipid with graphene nanoribbon

    Science.gov (United States)

    Akbari, Elnaz; Buntat, Zolkafle; Afroozeh, Abdolkarim; Zeinalinezhad, Alireza; Nilashi, Mehrbakhsh

    2015-09-01

    Single-layer graphene consists of sp 2-bonded carbon atoms arranged in a two-dimensional (2D) hexagonal lattice comprising a thin layer of single carbon atoms. Owing to its special characteristics including electrical, physical, and optical properties, graphene is considered more suitable for sensor applications than other materials. Moreover, it is possible to produce biosensors using electrolyte-gated field-effect transistors based on graphene (GFETs) to identify the alterations in charged lipid membrane properties. This paper illustrates how membrane thickness and electrical charge can result in a monolayer GFET, with emphasis on conductance variation. It is proposed that the thickness and electrical charge of the lipid bilayer are functions of carrier density, and equations relating these suitable control parameters were derived. Adaptive neuro fuzzy inference system (ANFIS) has been incorporated to obtain other model for conductance characteristic. The comparison between the analytical models and ANFIS with the experimental data extracted from previous work show an acceptable agreement. [Figure not available: see fulltext.

  18. Raman modes in transferred bilayer CVD graphene

    Directory of Open Access Journals (Sweden)

    Niilisk Ahti

    2015-01-01

    Full Text Available A systematic experimental Raman spectroscopic study of twisted bilayer graphene (tBLG domains localized inside wide-area single layer graphene (SLG produced by low-pressure CVD on Cu foil and transferred onto SiO2/Si substrate has been performed. According to the Raman characterization the tBLG domains had a great variety of twisting angles θ between the bottom and top graphene layers (6° < θ < 25°. The twisting angle θ was estimated from the spectral position of the rotating R and R' modes in the Raman spectrum.Under G band resonance conditions the breathing mode ZO' with a frequency of 95- 97 cm−1 was detected, and a breathing mode ZO was found in the spectra between 804 cm−1 and 836 cm−1, its position depending on the twisting angle θ. An almost linear relationship was found between the frequencies ωZO and ωR. Also a few other spectral peculiarities were found, e.g. a high-energy excitation of the G band resonance, the 2G overtone appearing at 3170-3180 cm−1 by the G band resonance, revealing a linear dispersion of 80 cm−1/eV of the 2D band in tBLG

  19. Localized plasmons in bilayer graphene nanodisks

    Science.gov (United States)

    Wang, Weihua; Xiao, Sanshui; Mortensen, N. Asger

    2016-04-01

    We study localized plasmonic excitations in bilayer graphene (BLG) nanodisks, comparing AA-stacked and AB-stacked BLG and contrasting the results to the case of two monolayers without electronic hybridization. The electrodynamic response of the BLG electron gas is described in terms of a spatially homogeneous surface conductivity, and an efficient alternative two-dimensional electrostatic approach is employed to carry out all the numerical calculations of plasmon resonances. Due to unique electronic band structures, the resonance frequency of the traditional dipolar plasmonic mode in the AA-stacked BLG nanodisk is roughly doping independent in the low-doping regime, while the mode is highly damped as the Fermi level approaches the interlayer hopping energy γ associated with tunneling of electrons between the two layers. In addition to the traditional dipolar mode, we find that the AB-stacked BLG nanodisk also hosts a new plasmonic mode with energy larger than γ . This mode can be tuned by either the doping level or structural size, and, furthermore, this mode can dominate the plasmonic response for realistic structural conditions.

  20. Thermoelectric power in a bilayer graphene device

    Science.gov (United States)

    Yung-Yu, Chien; Hongtao, Yuan; Chang-Ran, Wang; Chun-Hsuan, Lin; Wei-Li, Lee; Geballe LaboratoryAdvanced Materials Collaboration; Institute of Physics, Academia Sinica, Taipei, Taiwan Team

    2014-03-01

    There have been great interests on band gap engineering in a bilayer graphene (BLG) device, where inversion symmetry breaking by a perpendicular electric field can give rise to a sizable band gap. In our previous works, we have demonstrated a large enhancement in the thermoelectric power (TEP) associated with the band gap opening in a dual-gated BLG device. It is, therefore, an interesting question to ask whether even larger TEP can be achieved with a larger perpendicular electric field applied. We explored such possibility by utilizing the ionic liquid gating technique in BLG devices. By controlling the side gate voltage of ionic liquid and the bottom gate voltage via SiO2/Si substrate, large increase of the sheet resistance at charge neutral point was observed suggesting the opening of a band gap. At T = 120 K, TEP increases by more than 44% with a side gate voltage of ~ 1V. The influence of charge puddles to TEP using ionic liquid gating will be discussed.

  1. Mineral bridges in nacre revisited

    CERN Document Server

    Checa, Antonio G; Willinger, Marc-Georg

    2012-01-01

    We confirm with high-resolution techniques the existence of mineral bridges between superposed nacre tablets. In the towered nacre of both gastropods and the cephalopod Nautilus there are large bridges aligned along the tower axes, corresponding to gaps (150-200 nm) in the interlamellar membranes. Gaps are produced by the interaction of the nascent tablets with a surface membrane that covers the nacre compartment. In the terraced nacre of bivalves bridges associated with elongated gaps in the interlamellar membrane (> 100 nm) have mainly been found at or close to the edges of superposed parental tablets. To explain this placement, we hypothesize that the interlamellar membrane breaks due to differences in osmotic pressure across it when the interlamellar space below becomes reduced at an advanced stage of calcification. In no cases are the minor connections between superimposed tablets (< 60 nm), earlier reported to be mineral bridges, found to be such.

  2. Bridge Culture of Langde Village

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Langde, a village in Leishan County ofsouthwestern Guizhou province, is known for itslarge number of unique bridges bearing the distinctdesign style of the Miao ethnic group. Animpressive variety of well-preserved ancient

  3. Simulation of multivariate diffusion bridges

    DEFF Research Database (Denmark)

    Bladt, Mogens; Finch, Samuel; Sørensen, Michael

    We propose simple methods for multivariate diffusion bridge simulation, which plays a fundamental role in simulation-based likelihood and Bayesian inference for stochastic differential equations. By a novel application of classical coupling methods, the new approach generalizes a previously...

  4. Applications of overburden conveyor bridges

    Energy Technology Data Exchange (ETDEWEB)

    Schachtschneider, H.

    1987-06-01

    In large scale surface mines of the capacities required today, a cross-pit operation with overburden conveyor bridges is the most economical method of overburden removal and disposal. In order to provide the production capacity required in surface mining equipment by the GDR brown coal industry, VEB Schwermaschinenbau Lauchhammerwerk undertook the design and manufacture of standard overburden conveyor bridges for cut heights of 34 m, 45 m and 60 m. All three base types may be equipped to match the site specific geological and geotechnical conditions, and to meet customer's demands. Specifications of the bridges are given as well as details of conveyor belt speeds, modifications to the standards, and number manufactured. Design problems faced with the 60 m bridge are discussed, together with details of the superstructure, method of operation, transportation rates, structural steel used, assembly and power supply. 5 refs.

  5. ANGIOGRAPHIC ASPECTS OF MYOCARDIAL BRIDGES

    Directory of Open Access Journals (Sweden)

    Sujatha. M

    2015-12-01

    Full Text Available Introduction: The segment of epicardial coronary artery that traverses intramurally through the myocardium and bridged by a bunch of cardiac muscle fibers is called tunneled artery or intramural artery. The band of cardiac muscle fibers passing over the tunneled artery segment is named as myocardial bridge. During angiography milking effect is observed during systole due to the external pressure of muscle fibers on the tunneled artery that leads to narrowing of vessel lumen and further ischemia. Materials & Methods: It is a prospective study performed from 2012- 2015 in cardiac centers available around Tirupati, Andhra Pradesh, South India. A total number of 2015 adult patients who underwent diagnostic coronary angiography were evaluated to detect myocardial bridges. With the informed consent the relevant data was collected from the patients and analyzed. Results: The prevalence of myocardial bridges was 3.17%. Among the 2015 patients 70.7% are males and 29.2% are females. Among 64 myocardial bridge positive cases 62.5% were male and 37.5% were female patients. Regarding coronary dominance 84% were right dominant and 14.4% were left dominant and 1.6% are balanced. The percentage incidence of myocardial bridging according to dominance was 3.01% for right dominant patients, 4.12% for left dominant patients and 3.1% for balanced dominant patients. In all the myocardial bridge positive cases they were located on the left anterior descending artery (LAD. According to diagnosis the patients with normal coronaries were 22.6%, patients with MILD CAD were 17.9%, patients with single vessel disease were 23.4%, patients with two vessel disease were 14.7% and the patients with triple vessel disease were 21.3%. The 64 myocardial bridging cases were grouped in to three groups according to their age. Incidence of double bridges was observed in 3 cases of which 66.7% males & 33.3% in females. Conclusion: These results show that Andhra Pradesh population are

  6. Enhanced magnetic response and metallicity in AB stacked bilayer graphene via Cr-doping

    Energy Technology Data Exchange (ETDEWEB)

    Thakur, Jyoti [Department of Physics, Kurukshetra University, Kurukshetra 136119, Haryana (India); Kashyap, Manish K., E-mail: manishdft@gmail.com [Department of Physics, Kurukshetra University, Kurukshetra 136119, Haryana (India); Saini, Hardev S. [Department of Physics, Panjab University, Chandigarh 160014 (India); Reshak, Ali H. [New Technologies – Research Centre, University of West Bohemia, Univerzitni 8, 306 14 Pilsen (Czech Republic); Center of Excellence Geopolymer and Green Technology, School of Material Engineering, University Malaysia Perlis, 01007 Kangar, Perlis (Malaysia)

    2015-11-15

    First-principles study for the electronic and magnetic properties of Cr atom doping in lower layer of AB bernal stacked bilayer graphene (BLG) is presented. This doping is analysed in three different configurations; (i) Hollow type (above the centre of C hexagon), (ii) Top-type (directly on the top of any C atom) and (iii) Bridge type (mid point of any C–C bond). It has been observed that the doping of Cr atom enlarges the interlayer spacing in BLG as compared to pure one. The Top-type (T-type) doping is found to be most stable energetically. The doping of Cr atom in all configurations generates the large spin polarization and induces the appreciable magnetic moment. Half metallicity has been obtained in Hollow type (H-type) doping with a suitable band gap of 0.28 eV in minority spin channel. The origin of magnetism has been identified via interactions of 3d-states of doped Cr atom with p-states of inequivalent C atoms present in the vicinity of doping site. The electron densities plots also confirm the metallic nature of Cr-doped BLG. Our results reveal that the resultant BLG has potential for futuristic applications such as high frequency transistors, spintronics, photodetectors and energy resources. - Highlights: • Cr-doping in bilayer graphene induces magnetic channel. • Half metallicity is observed only in H-type Cr-doping in graphene. • T-type doping is most energetically stable among all types (H-type, B-type and T-type). • The strong hybridization of Cr-3d states with C-p states governs the magnetism in BLG.

  7. Molecular architecture of nanocapsules, bilayer-enclosed solid particles of Cisplatin.

    Science.gov (United States)

    Chupin, Vladimir; de Kroon, Anton I P M; de Kruijff, Ben

    2004-10-27

    Cisplatin nanocapsules represent a lipid formulation of the anticancer drug cis-diamminedichloroplatinum(II) (cisplatin) characterized by an unprecedented cisplatin-to-lipid ratio and exhibiting strongly improved cytotoxicity against tumor cells in vitro as compared to the free drug (Burger, K. N. J., et al. Nat. Med. 2002, 8, 81-84). Cisplatin nanocapsules are prepared by the repeated freezing and thawing of an equimolar dispersion of phosphatidylserine (PS) and phosphatidylcholine (PC) in a concentrated aqueous solution of cisplatin. Here, the molecular architecture of these novel nanostructures was elucidated by solid-state NMR techniques. 15N NMR and 2H NMR spectra of nanocapsules containing 15N- and 2H-labeled cisplatin, respectively, demonstrated that the core of the nanocapsules consists of solid cisplatin devoid of free water. Magic-angle spinning 15N NMR showed that approximately 90% of the cisplatin in the core is present as the dichloro species. The remaining 10% was accounted for by a newly discovered dinuclear Pt compound that was identified as the positively charged chloride-bridged dimer of cisplatin. NMR techniques sensitive to lipid organization, 31P NMR and 2H NMR, revealed that the cisplatin core is coated by phospholipids in a bilayer configuration and that the interaction between solid core and bilayer coat exerts a strong ordering effect on the phospholipid molecules. Compared to phospholipids in liposomal membranes, the motion of the phospholipid headgroups is restricted and the ordering of the acyl chains is increased, particularly in PS. The implications of these findings for the structural organization, the mechanism of formation, and the mode of action of cisplatin nanocapsules are discussed. PMID:15493941

  8. ANGIOGRAPHIC ASPECTS OF MYOCARDIAL BRIDGES

    OpenAIRE

    Sujatha M; V Subhadra Devi; C. S. S. Raju; B. Yugandhar; Nagaraju

    2015-01-01

    Introduction: The segment of epicardial coronary artery that traverses intramurally through the myocardium and bridged by a bunch of cardiac muscle fibers is called tunneled artery or intramural artery. The band of cardiac muscle fibers passing over the tunneled artery segment is named as myocardial bridge. During angiography milking effect is observed during systole due to the external pressure of muscle fibers on the tunneled artery that leads to narrowing of vessel lumen and further isc...

  9. SURGERY OF SYMPTOMATIC MYOCARDIAL BRIDGING

    OpenAIRE

    N. Maghamipour N. Safaei

    2007-01-01

    Myocardial bridging with systolic compression of the left anterior descending coronary artery (LAD) may be associated with myocardial ischemia. In symptomatic myocardial bridging unresponsive to medical treatment, surgical unroofing of the left LAD can be performed. Little information is available about the long-term prognosis of patients with this coronary anomaly after the surgical unroofing, so we decided to evaluate the result of this operation. A total of 26 patients underwent surgical u...

  10. Stability of liquid crystalline bridges

    Science.gov (United States)

    Mahajan, Milind P.; Tsige, Mesfin; Taylor, P. L.; Rosenblatt, Charles

    1999-02-01

    The stability of cylindrical bridges of the liquid crystal octylcyanobiphenyl in an immiscible liquid bath was investigated in the nematic and smectic A phases. In the nematic phase the bridge was found to destabilize at a length-to-diameter (slenderness) ratio R similar to that of ordinary Newtonian fluids. On the other hand, the Bingham behavior of the smectic A phase, i.e., an apparent yield stress, enabled the formation of stable columns with R well in excess of π.

  11. SURGERY OF SYMPTOMATIC MYOCARDIAL BRIDGING

    Directory of Open Access Journals (Sweden)

    N. Maghamipour N. Safaei

    2007-06-01

    Full Text Available Myocardial bridging with systolic compression of the left anterior descending coronary artery (LAD may be associated with myocardial ischemia. In symptomatic myocardial bridging unresponsive to medical treatment, surgical unroofing of the left LAD can be performed. Little information is available about the long-term prognosis of patients with this coronary anomaly after the surgical unroofing, so we decided to evaluate the result of this operation. A total of 26 patients underwent surgical unroofing of myocardial bridging. Patients had a myocardial bridge of at least 3 cm in length in the middle of LAD and with more than 70% compression during systole. Unroofing was performed with cardiopulmonary bypass in 16 and with off pump technique in 10 patients. In 6 patients repeat angiographies for control of myotomy were done. In one of them a nonsignificant 20% narrowing was seen. Postoperative scintigraphic and angiographic studies demonstrated restoration of coronary flow and myocardial perfusion without residual myocardial bridges under beta-stimulation in 24 patients. Two patients had residual narrowing. With off pump technique, 1 patient had perforation of the right ventricle and 1 patient underwent reoperation because of incomplete unroofing during the first operation. None of the patients with cardiopulmonary bypass technique had residual chest pain or other complications. Surgical unroofing of myocardial bridging with the aid of cardiopulmonary bypass is a safe and easy procedure with low operative risk and with excellent functional results.

  12. Wave-current force on bridge foundation

    OpenAIRE

    Pan, J.N.; Wang, D.T.; Wang, X. G.; Nie, F

    2013-01-01

    Many cross-sea bridges have been constructed or in construction in the Chinese coastal areas, such as Hangzhou Bay Bridge, East China Sea Bridge and Hong Kong-Zhuhai-Macau Bridge, etc. Usually the foundations of cross-sea bridges will bear the load of wave and current simultaneously, the extreme value of which is an important factor for bridge design. It is quite difficult to estimate the extreme wave-current forces on bridge foundations due to their complex form, for example a polygonal plat...

  13. Redundancy Evaluation of Fracture Critical Bridges

    OpenAIRE

    Bapat, Amey Vivek

    2014-01-01

    Cases of brittle fractures in major bridges prompted AASHTO to publish its first fracture control plan in 1978. It focused on material and fabrication standards, and required periodic 24-month hands-on inspection of bridges with fracture critical members. The practical result of this plan was to significantly increase the life cycle cost of these bridges, rendering them uneconomical. Apart from the Point Pleasant Bridge that failed in 1967, no other bridge has collapsed in the USA following a...

  14. Interleaflet mixing and coupling in liquid-disordered phospholipid bilayers.

    Science.gov (United States)

    Capponi, Sara; Freites, J Alfredo; Tobias, Douglas J; White, Stephen H

    2016-02-01

    Organized as bilayers, phospholipids are the fundamental building blocks of cellular membranes and determine many of their biological functions. Interactions between the two leaflets of the bilayer (interleaflet coupling) have been implicated in the passage of information through membranes. However, physically, the meaning of interleaflet coupling is ill defined and lacks a structural basis. Using all-atom molecular dynamics simulations of fluid phospholipid bilayers of five different lipids with differing degrees of acyl-chain asymmetry, we have examined interleaflet mixing to gain insights into coupling. Reasoning that the transbilayer distribution of terminal methyl groups is an appropriate measure of interleaflet mixing, we calculated the transbilayer distributions of the acyl chain terminal methyl groups for five lipids: dioleoylphosphatidylcholine (DOPC), palmitoyloleoylphosphatidylcholine (POPC), stearoyloleoylphosphatidylcholine (SOPC), oleoylmyristoylphosphatidylcholine (OMPC), and dimyristoylphosphatidylcholine (DMPC). We observed in all cases very strong mixing across the bilayer midplane that diminished somewhat with increasing acyl-chain ordering defined by methylene order parameters. A hallmark of the interleaflet coupling idea is complementarity, which postulates that lipids with short alkyl chains in one leaflet will preferentially associate with lipids with long alkyl chains in the other leaflet. Our results suggest a much more complicated picture for thermally disordered bilayers that we call distributed complementarity, as measured by the difference in the peak positions of the sn-1 and sn-2 methyl distributions in the same leaflet. PMID:26657692

  15. Hydrogel-Stabilized Droplet Bilayers for High Speed Solution Exchange

    Science.gov (United States)

    Acharya, Shiv A.; Portman, Alexander; Salazar, Carl S.; Schmidt, Jacob J.

    2013-11-01

    Many applications utilizing artificial lipid bilayers require the ability to exchange the bilayer's solution environment. However, because of the instability of the bilayer, the rate of solution exchange is limited, which significantly hinders the measurement rate and throughput. We have developed an artificial bilayer system that can withstand high flow speeds, up to 2.1 m/s, by supporting the bilayer with a hydrogel. We demonstrated the ability to measure during flow by measuring the conductance of gramicidin-A channels while switching between solutions of two different compositions, recording a time to measure 90% change in current of approximately 2.7 seconds at a flow rate of 0.1 m/s. We also demonstrated a potential application of this system by measuring the conductance modulation of the rat TRPM8 ion channel by an agonist and antagonist at varying concentrations, obtaining 7-point IC50 and EC50 values in approximately 7 minutes and 4-point values within 4 minutes.

  16. Functional reconstitution of ICln in lipid bilayers.

    Science.gov (United States)

    Fürst, J; Bazzini, C; Jakab, M; Meyer, G; König, M; Gschwentner, M; Ritter, M; Schmarda, A; Bottà, G; Benz, R; Deetjen, P; Paulmichl, M

    2000-05-01

    Reconstitution of purified ICln in lipid bilayer leads to functional ion channels showing varying rectification. The reconstituted single channels have a conductance of approximately equal to 3 pS and their open probability is sensitive to nucleoside analogues. Mutation of a putative nucleotide binding site identified at the predicted extracellular mouth of the ICln channel protein leads to the reduction of the nucleoside-analogue sensitivity. Reconstituted ICln channels can be permeated both by cations and anions. The relative permeability of cations over anions depends on the presence of calcium. In the presence of calcium reconstituted ICln channels are more permeable to bromide than chloride, and more permeable to potassium than sodium. Similarly in NIH3T3 fibroblasts, the relative permeability of cations over anions of swelling-dependent chloride channels depends on extracellular calcium. Site-directed mutagenesis revealed the calcium-binding site responsible for the shift of the selectivity from cations towards anions of reconstituted ICln channels. Additional indirect structural information has been obtained by mutating a histidine in the predicted pore region of ICln. This histidine seems to have access to the ion-conducting tunnel of the pore. Our experiments show that ICln can act as an ionic channel, which does not exclude additional functions of the protein in regulatory mechanisms of the cell. Since knocking down the ICln protein in fibroblasts and epithelial cells leads to an impaired regulatory volume decrease (RVD) after cytoplasmic swelling and reconstituted ICln channels show several biophysical features of ion channels activated after swelling, ICln is a molecular candidate for these channels. PMID:10864003

  17. Assessment of pseudo-bilayer structures in the heterogate germanium electron-hole bilayer tunnel field-effect transistor

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, J. L., E-mail: jose.padilladelatorre@epfl.ch; Alper, C.; Ionescu, A. M. [Nanoelectronic Devices Laboratory, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015 (Switzerland); Medina-Bailón, C.; Gámiz, F. [Departamento de Electrónica y Tecnología de los Computadores, Universidad de Granada, Avda. Fuentenueva s/n, 18071 Granada (Spain)

    2015-06-29

    We investigate the effect of pseudo-bilayer configurations at low operating voltages (≤0.5 V) in the heterogate germanium electron-hole bilayer tunnel field-effect transistor (HG-EHBTFET) compared to the traditional bilayer structures of EHBTFETs arising from semiclassical simulations where the inversion layers for electrons and holes featured very symmetric profiles with similar concentration levels at the ON-state. Pseudo-bilayer layouts are attained by inducing a certain asymmetry between the top and the bottom gates so that even though the hole inversion layer is formed at the bottom of the channel, the top gate voltage remains below the required value to trigger the formation of the inversion layer for electrons. Resulting benefits from this setup are improved electrostatic control on the channel, enhanced gate-to-gate efficiency, and higher I{sub ON} levels. Furthermore, pseudo-bilayer configurations alleviate the difficulties derived from confining very high opposite carrier concentrations in very thin structures.

  18. Assessment of pseudo-bilayer structures in the heterogate germanium electron-hole bilayer tunnel field-effect transistor

    International Nuclear Information System (INIS)

    We investigate the effect of pseudo-bilayer configurations at low operating voltages (≤0.5 V) in the heterogate germanium electron-hole bilayer tunnel field-effect transistor (HG-EHBTFET) compared to the traditional bilayer structures of EHBTFETs arising from semiclassical simulations where the inversion layers for electrons and holes featured very symmetric profiles with similar concentration levels at the ON-state. Pseudo-bilayer layouts are attained by inducing a certain asymmetry between the top and the bottom gates so that even though the hole inversion layer is formed at the bottom of the channel, the top gate voltage remains below the required value to trigger the formation of the inversion layer for electrons. Resulting benefits from this setup are improved electrostatic control on the channel, enhanced gate-to-gate efficiency, and higher ION levels. Furthermore, pseudo-bilayer configurations alleviate the difficulties derived from confining very high opposite carrier concentrations in very thin structures

  19. Preisach analysis of epitaxial hard/soft bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Cornejo, D.R.; Rhen, F.M.; Missell, F.P. E-mail: fmissell@macbeth.if.usp.br; Fullerton, E.E

    2001-05-01

    We used the moving Preisach model to study the magnetization-reversal process in epitaxial SmCo (1 1 =macron 0 0)/Fe bilayers prepared by magnetron sputtering. The SmCo(20 nm)/Fe(t nm) (t=0, 5, 10, 20) bilayers were grown onto single-crystal (1 1 0)MgO substrates with an epitaxial 20 nm Cr(2 1 1) buffer layer. The second-quadrant magnetization curves were strictly reversible up to a field H{sub 0}, close to the field H{sub c} at which the magnetization switched irreversibly. Henkel plots for these bilayers indicated very strong magnetizing interactions for all films. Magnetization reversal in these films reflects their epitaxial structure.

  20. Bilayer polymer/oxide coating for electroluminescent organic semiconductors

    DEFF Research Database (Denmark)

    Tavares, Luciana

    of the fibers with oxygen. We have developed a bilayer coating that does not change significantly the p6P spectrum but strongly reduces bleaching. This bilayer coating consists of a first layer of a stable polymer (PMMA) on top of the organic nanofibers as a protecting layer for avoiding...... modifications of the p6P luminescence spectrum and as a second layer SiOx for blocking the oxyg en penetration. In this work, we show the applicability of this bilayer coating of PMMA/SiOx in prolonging the operational lifetime of field-effect transistor (FET) devices based on p6P nanofibers. The coating...... prevents strong degradation of transferred nanofibers on FET platforms during electrical biasing as is observed for uncoated devices. We are currently investigating the effect of the coating during electrically stimulated light emission experiments from transferred fibers on transistor platforms....

  1. Neutron diffraction studies of amphipathic helices in phospholipid bilayers

    International Nuclear Information System (INIS)

    The structural feature which is thought to facilitate the interaction of many peptides with phospholipid bilayers is the ability to fold into an amphipathic helix. In most cases the exact location and orientation of this helix with respect to the membrane is not known, and may vary with factors such as pH and phospholipid content of the bilayer. The growing interest in this area is stimulated by indications that similar interactions can contribute to the binding of certain hormones to their cell-surface receptors. We have been using the techniques of neutron diffraction from stacked phospholipid bilayers in an attempt to investigate this phenomenon with a number of membrane-active peptides. Here we report some of our findings with three of these: the bee venom melittin; the hormone calcitonin; and a synthetic peptide representing the ion channel fragment of influenza A M2 protein

  2. Sodium chloride's effect on self-assembly of diphenylalanine bilayer.

    Science.gov (United States)

    Kwon, Junpyo; Lee, Myeongsang; Na, Sungsoo

    2016-07-15

    Understanding self-assembling peptides becomes essential in nanotechnology, thereby providing a bottom-up method for fabrication of nanostructures. Diphenylalanine constitutes an outstanding building block that can be assembled into various nanostructures, including two-dimensional bilayers or nanotubes, exhibiting superb mechanical properties. It is known that the effect of the ions is critical in conformational and chemical interactions of bilayers or membranes. In this study, we analyzed the effect of sodium chloride on diphenylalanine bilayer using coarse-grained molecular dynamics simulations, and calculated the bending Young's modulus and the torsional modulus by applying normal modal analysis using an elastic network model. The results showed that sodium chloride dramatically increases the assembling efficiency and stability, thereby promising to allow the precise design and control of the fabrication process and properties of bio-inspired materials. © 2016 Wiley Periodicals, Inc. PMID:27241039

  3. The organization of n-alkanes in lipid bilayers.

    Science.gov (United States)

    McIntosh, T J; Simon, S A; MacDonald, R C

    1980-04-24

    The interaction of n-alkanes (C6--C16) with phosphatidylcholine has been studied by the combined use of differential scanning calorimetry, X-ray diffraction and monolayer techniques. It has been found that the thermal properties and ultrastructure of lipid-alkane vesicles are strongly dependent on the length of the n-alkanes. Long alkanes, such as tetradecane and hexadecane, increase the transition temperature of dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine, while the X-ray data indicate that these long alkanes align parallel to the lipid acyl chains. In contrast, shorter alkanes, such as hexane and octane, decrease and broaden the thermal transition and electron density profiles show that these alkanes increase bilayer width by partitioning between the apposing monolayers of the bilayer. For lipids in the gel and liquid crystalline states, the short alkanes form an alkane region in the geometric center of the bilayer. PMID:6892885

  4. Neutron diffraction studies of amphipathic helices in phospholipid bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Bradshaw, J.P.; Gilchrist, P.J. [Univ. of Edinburgh (United Kingdom); Duff, K.C. [Univ. of Edinburgh Medical School (United Kingdom); Saxena, A.M. [Brookhaven National Laboratory, Upton, NY (United States)

    1994-12-31

    The structural feature which is thought to facilitate the interaction of many peptides with phospholipid bilayers is the ability to fold into an amphipathic helix. In most cases the exact location and orientation of this helix with respect to the membrane is not known, and may vary with factors such as pH and phospholipid content of the bilayer. The growing interest in this area is stimulated by indications that similar interactions can contribute to the binding of certain hormones to their cell-surface receptors. We have been using the techniques of neutron diffraction from stacked phospholipid bilayers in an attempt to investigate this phenomenon with a number of membrane-active peptides. Here we report some of our findings with three of these: the bee venom melittin; the hormone calcitonin; and a synthetic peptide representing the ion channel fragment of influenza A M2 protein.

  5. Interaction driven quantum Hall effect in artificially stacked graphene bilayers

    Science.gov (United States)

    Iqbal, Muhammad Zahir; Iqbal, Muhammad Waqas; Siddique, Salma; Khan, Muhammad Farooq; Ramay, Shahid Mahmood; Nam, Jungtae; Kim, Keun Soo; Eom, Jonghwa

    2016-04-01

    The honeycomb lattice structure of graphene gives rise to its exceptional electronic properties of linear dispersion relation and its chiral nature of charge carriers. The exceptional electronic properties of graphene stem from linear dispersion relation and chiral nature of charge carries, originating from its honeycomb lattice structure. Here, we address the quantum Hall effect in artificially stacked graphene bilayers and single layer graphene grown by chemical vapor deposition. The quantum Hall plateaus started to appear more than 3 T and became clearer at higher magnetic fields up to 9 T. Shubnikov-de Hass oscillations were manifestly observed in graphene bilayers texture. These unusual plateaus may have been due to the layers interaction in artificially stacked graphene bilayers. Our study initiates the understanding of interactions between artificially stacked graphene layers.

  6. Interaction driven quantum Hall effect in artificially stacked graphene bilayers

    Science.gov (United States)

    Iqbal, Muhammad Zahir; Iqbal, Muhammad Waqas; Siddique, Salma; Khan, Muhammad Farooq; Ramay, Shahid Mahmood; Nam, Jungtae; Kim, Keun Soo; Eom, Jonghwa

    2016-01-01

    The honeycomb lattice structure of graphene gives rise to its exceptional electronic properties of linear dispersion relation and its chiral nature of charge carriers. The exceptional electronic properties of graphene stem from linear dispersion relation and chiral nature of charge carries, originating from its honeycomb lattice structure. Here, we address the quantum Hall effect in artificially stacked graphene bilayers and single layer graphene grown by chemical vapor deposition. The quantum Hall plateaus started to appear more than 3 T and became clearer at higher magnetic fields up to 9 T. Shubnikov-de Hass oscillations were manifestly observed in graphene bilayers texture. These unusual plateaus may have been due to the layers interaction in artificially stacked graphene bilayers. Our study initiates the understanding of interactions between artificially stacked graphene layers. PMID:27098387

  7. Equilibrium Configurations of Lipid Bilayer Membranes and Carbon Nanostructures

    Institute of Scientific and Technical Information of China (English)

    Iva(i)lo M.Mladenov; Peter A.Djondjorov; Mariana Ts.Hadzhilazova; Vassil M.Vassilev

    2013-01-01

    The present article concerns the continuum modelling of the mechanical behaviour and equilibrium shapes of two types of nano-scale objects:fluid lipid bilayer membranes and carbon nanostructures.A unified continuum model is used to handle four different case studies.Two of them consist in representing in analytic form cylindrical and axisymmetric equilibrium configurations of single-wall carbon nanotubes and fluid lipid bilayer membranes subjected to uniform hydrostatic pressure.The third one is concerned with determination of possible shapes of junctions between a single-wall carbon nanotube and a fiat graphene sheet or another single-wall carbon nanotube.The last one deals with the mechanical behaviour of closed fluid lipid bilayer membranes (vesicles) adhering onto a fiat homogeneous rigid substrate subjected to micro-injection and uniform hydrostatic pressure.

  8. Lipid peroxidation and water penetration in lipid bilayers

    DEFF Research Database (Denmark)

    Conte, Elena; Megli, Francesco Maria; Khandelia, Himanshu;

    2012-01-01

    Lipid peroxidation plays a key role in the alteration of cell membrane's properties. Here we used as model systems multilamellar vesicles (MLVs) made of the first two products in the oxidative cascade of linoleoyl lecithin, namely 1-palmitoyl-2-(13-hydroperoxy-9,11-octadecanedienoyl)-lecithin (Hp......(zz) parameters revealed that OHPLPC, but mostly HpPLPC, induced a measurable increase in polarity and H-bonding propensity in the central region of the bilayer. Molecular dynamics simulation performed on 16-DSA in the PLPC-HpPLPC bilayer revealed that water molecules are statistically favored with respect to the...... hydroperoxide groups to interact with the nitroxide at the methyl-terminal, confirming that the H-bonds experimentally observed are due to increased water penetration in the bilayer. The EPR and MD data on model membranes demonstrate that cell membrane damage by oxidative stress cause alteration of water...

  9. Edge State and Intrinsic Hole Doping in Bilayer Phosphorene

    Science.gov (United States)

    Osada, Toshihito

    2015-01-01

    Using a simple LCAO model by Harrison, we have qualitatively studied the edge state of bilayer phosphorene, which is a unit structure of the layered crystal of black phosphorus. This model successfully reproduces the isolated edge state in the bulk gap in monolayer phosphorene. In bilayer phosphorene, however, it shows that edge states are almost buried in the valence band and there is no isolated midgap edge state at the zigzag edge. Since the buried edge state works as acceptor, holes are doped from the edge state into the bulk. This gives a possible explanation for p-type conduction in undoped black phosphorus. Under the vertical electric field, the intrinsic hole doping is reduced because a part of edge states move into the gap. These features of bilayer phosphorene might be better suited for device application.

  10. Electronic transport in B-N substituted bilayer graphene nanojunctions

    Science.gov (United States)

    Giofré, Daniele; Ceresoli, Davide; Fratesi, Guido; Trioni, Mario I.

    2016-05-01

    We investigated a suspended bilayer graphene where the bottom/top layer is doped by boron/nitrogen substitutional atoms. By using density functional theory calculations, we found that at high dopant concentration (one B-N pair every 32 C atoms), the electronic structure of the bilayer does not depend on the B-N distance but on the relative occupation of the bilayer graphene sublattices by B and N. The presence of the dopants and the consequent charge transfer establish a built-in electric field between the layers, giving rise to an energy gap. We further investigated the electronic transport properties and found that intralayer current is weakly influenced by the presence of these dopants while the interlayer one is enhanced for biases, allowing an easy tunneling between layers. This effect leads to current rectification in asymmetric junctions.

  11. Manipulating interface states in monolayer–bilayer graphene planar junctions

    Science.gov (United States)

    Zhao, Fang; Xu, Lei; Zhang, Jun

    2016-05-01

    We report on transport properties of monolayer–bilayer graphene planar junctions in a magnetic field. Due to its unique geometry, the edge and interface states can be independently manipulated by either interlayer potential or Zeeman field, and the conductance exhibits interesting quantized behaviors. In the hybrid graphene junction, the quantum Hall (QH) conductance is no longer antisymmetric with respect to the charge neutrality point. When the Zeeman field is considered, a quantum spin Hall (QSH) phase is found in the monolayer region while the weak-QSH phase stays in the bilayer region. In the presence of both interlayer potential and Zeeman field, the bilayer region hosts a QSH phase, whereas the monolayer region is still in a QH phase, leading to a spin-polarized current in the interface. In particular, the QSH phase remains robust against the disorder.

  12. A strange bridge by Leonardo

    CERN Document Server

    Huylebrouck, Dirk

    2013-01-01

    On folio 855 recto of the Codex Atlanticus, Leonardo da Vinci drew three 'easily movable' bridges, but one of them is enigmatic: all 'replicas' in Leonardo museums and exhibitions come as a surprise, to say the least, to any engineer or architect whose attention is drawn to it. This is the case for models in Amboise (France), Chicago and Portland (USA), Florence (Italy) and for the one of the traveling exhibition by the Australian company 'Grande Exhibitions' that already visited 40 major cities in the world. All 'replicas' of the bridge model attributed to Leonardo have pillars standing on the deck of the bridge, while the deck is suspended by cables attached on these pillars. At first sight this problem does not catch the attention of the observer, as the bridge seems to be a mixed form of a beam and a suspension bridge, but it was not overlooked by my colleague architect-engineer Dr. Laurens Luyten (Gent, Belgium). Yet, after a TV-interview in Brussels so much pressure was exerted by some of the museum col...

  13. Floating liquid bridge charge dynamics

    Science.gov (United States)

    Teschke, Omar; Soares, David Mendez; Gomes, Whyllerson Evaristo; Valente Filho, Juracyr Ferraz

    2016-01-01

    The interaction of liquid with electric fields is investigated in a configuration where up to 13 kV are applied between electrodes resulting in a 106 V/m electric field in the capillaries and where there is the formation of a free-standing fluid bridge in the interelectrode gap. The Mott-Gurney equation was fitted to the measured ionization current vs applied voltage curve which indicates that the ionization rate at the high-voltage anode electrode dimethylsulfoxide (DMSO) interface and space charging in the interelectrode gap determine the floating liquid bridge current for a given cathode-to-anode voltage. Space charge effects were measured in the cathode becker and also at the liquid bridge since the ionized charges at the anode migrate to the bridge outer surface and decrease the interfacial tension from 43 mJ/m2 to 29 mJ/m2. Two distinct structural regions then form the bridge, a charged plastic (bulk modulus ˜100 MPa) conducting outer layer with a surface conductivity of ˜10-9 Ω-1, which shapes and supports the floating fluid structure, and an inner liquid cylinder, where DMSO molecules flow.

  14. Efficient Organic Photovoltaics Utilizing Nanoscale Heterojunctions in Sequentially Deposited Polymer/fullerene Bilayer

    OpenAIRE

    Seok, Jeesoo; Shin, Tae Joo; Park, Sungmin; Cho, Changsoon; Lee, Jung-Yong; Yeol Ryu, Du; Kim, Myung Hwa; Kim, Kyungkon

    2015-01-01

    A highly efficient sequentially deposited bilayer (SD-bilayer) of polymer/fullerene organic photovoltaic (OPV) device is developed via the solution process. Herein, we resolve two essential problems regarding the construction of an efficient SD-bilayer OPV. First, the solution process fabrication of the SD-bilayer is resolved by incorporating an ordering agent (OA) to the polymer solution, which improves the ordering of the polymer chain and prevents the bottom-layer from dissolving into the ...

  15. Optical and electrical properties of Mg/Co bilayer thin film metal hydrides

    OpenAIRE

    M. K. JANGID,; S.P. Nehra; M Singh

    2010-01-01

    Bilayer Mg/Co thin films have been prepared using thermal evaporation method at pressure 10-5 torr. Annealing of bilayer thin films have been performed for 1 hour at different temperature. Hydrogenation of pristine and annealed bilayer structure has been performed at different hydrogen pressure for half an hour. The optical transmission increased with hydrogen pressure and also the band gap of thin films found to be increase with hydrogen pressure. Pristine Mg/Co bilayers show ohmic behavior ...

  16. Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

    DEFF Research Database (Denmark)

    Lundbæk, Jens August; Collingwood, S.A.; Ingolfsson, H.I.;

    2010-01-01

    Membrane protein function is regulated by the host lipid bilayer composition. This regulation may depend on specific chemical interactions between proteins and individual molecules in the bilayer, as well as on non-specific interactions between proteins and the bilayer behaving as a physical enti...... use of gramicidin channels as molecular force probes for studying this mechanism, with a unique ability to discriminate between consequences of changes in monolayer curvature and bilayer elastic moduli....

  17. Transport methods for probing the barrier domain of lipid bilayer membranes.

    OpenAIRE

    Xiang, T X; Chen, X.; Anderson, B. D.

    1992-01-01

    Two experimental techniques have been utilized to explore the barrier properties of lecithin/decane bilayer membranes with the aim of determining the contributions of various domains within the bilayer to the overall barrier. The thickness of lecithin/decane bilayers was systematically varied by modulating the chemical potential of decane in the annulus surrounding the bilayer using different mole fractions of squalene in decane. The dependence of permeability of a model permeant (acetamide) ...

  18. Manipulating lipid bilayer material properties using biologically active amphipathic molecules

    Energy Technology Data Exchange (ETDEWEB)

    Ashrafuzzaman, Md [Department of Physiology and Biophysics, Weill Medical College of University of Cornell, New York, NY 10021 (United States); Lampson, M A [Department of Physiology and Biophysics, Weill Medical College of University of Cornell, New York, NY 10021 (United States); Greathouse, D V [Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701 (United States); II, R E Koeppe [Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701 (United States); Andersen, O S [Department of Physiology and Biophysics, Weill Medical College of University of Cornell, New York, NY 10021 (United States)

    2006-07-19

    Lipid bilayers are elastic bodies with properties that can be manipulated/controlled by the adsorption of amphipathic molecules. The resulting changes in bilayer elasticity have been shown to regulate integral membrane protein function. To further understand the amphiphile-induced modulation of bilayer material properties (thickness, intrinsic monolayer curvature and elastic moduli), we examined how an enantiomeric pair of viral anti-fusion peptides (AFPs)-Z-Gly-D-Phe and Z-Gly-Phe, where Z denotes a benzyloxycarbonyl group, as well as Z-Phe-Tyr and Z-D-Phe-Phe-Gly-alters the function of enantiomeric pairs of gramicidin channels of different lengths in planar bilayers. For both short and long channels, the channel lifetimes and appearance frequencies increase as linear functions of the aqueous AFP concentration, with no apparent effect on the single-channel conductance. These changes in channel function do not depend on the chirality of the channels or the AFPs. At pH 7.0, the relative changes in channel lifetimes do not vary when the channel length is varied, indicating that these compounds exert their effects primarily by causing a positive-going change in the intrinsic monolayer curvature. At pH 4.0, the AFPs are more potent than at pH 7.0 and have greater effects on the shorter channels, indicating that these compounds now change the bilayer elastic moduli. When AFPs of different anti-fusion potencies are compared, the rank order of the anti-fusion activity and the channel-modifying activity is similar, but the relative changes in anti-fusion potency are larger than the changes in channel-modifying activity. We conclude that gramicidin channels are useful as molecular force transducers to probe the influence of small amphiphiles upon lipid bilayer material properties.

  19. Diffraction studies on natural and model lipid bilayers

    Science.gov (United States)

    Sebastiani, F.; Harvey, R.; Khanniche, S.; Artero, J.-B.; Haertlein, M.; Fragneto, G.

    2012-11-01

    In this study we have used neutron diffraction to examine the swelling behaviour and bilayer parameters of membranes reconstituted from polar lipids extracted from B. subtilis and model systems composed of synthetic phospholipids. Evidence for phase separation in the model system (lacking in Lysyl-PG, L-PG) is discussed in relation to its possible contribution to membrane domain formation through lipid-lipid interactions. Comparing these results with those obtained from the bilayers composed of lipids extracted from bacterial cells gives us some indication of the role of L-PG in the B. subtilis plasma membrane.

  20. Enhanced Configurational Entropy in High-Density Nanoconfined Bilayer Ice

    Science.gov (United States)

    Corsetti, Fabiano; Zubeltzu, Jon; Artacho, Emilio

    2016-02-01

    A novel kind of crystal order in high-density nanoconfined bilayer ice is proposed from molecular dynamics and density-functional theory simulations. A first-order transition is observed between a low-temperature proton-ordered solid and a high-temperature proton-disordered solid. The latter is shown to possess crystalline order for the oxygen positions, arranged on a close-packed triangular lattice with A A stacking. Uniquely among the ice phases, the triangular bilayer is characterized by two levels of disorder (for the bonding network and for the protons) which results in a configurational entropy twice that of bulk ice.

  1. Bilayer graphene Hall bar with a pn-junction

    OpenAIRE

    Milovanovic, S. P.; Masir, M. Ramezani; Peeters, F. M.

    2013-01-01

    We investigate the magnetic field dependence of the Hall and the bend resistances for a ballistic Hall bar structure containing a pn-junction sculptured from a bilayer of graphene. The electric response is obtained using the billiard model and we investigate the cases of bilayer graphene with and without a band gap. Two different conduction regimes are possible: $i$) both sides of the junction have the same carrier type, and $ii$) one side of the junction is n-type while the other one is p-ty...

  2. Structure and metastability of N-lignocerylgalactosylsphingosine (cerebroside) bilayers.

    Science.gov (United States)

    Reed, R A; Shipley, G G

    1987-01-26

    Differential scanning calorimetry (DSC) and X-ray diffraction have been used to study hydrated N-lignocerylgalactosylsphingosine (NLGS) bilayers. DSC of fully hydrated NLGS shows an endothermic transition at 69-70 degrees C, immediately followed by an exothermic transition at 72-73 degrees C; further heating shows a high-temperature (Tc = 82 degrees C), high-enthalpy (delta H = 15.3 kcal/mol NLGS) transition. Heating to 75 degrees C, cooling to 20 degrees C and subsequent reheating shows no transitions at 69-73 degrees C; only the high-temperature (82 degrees C), high-enthalpy (15.3 kcal/mol) transition. Two exothermic transitions are observed on cooling; for the upper transition its temperature (about 65 degrees C) and enthalpy (about 6 kcal/mol NLGS) are essentially independent of cooling rate, whereas the lower transition exhibits marked changes in both temperature (30----60 degrees C) and enthalpy (2.2----9.5 kcal/mol NLGS) as the cooling rate decreases from 40 to 0.625 Cdeg/min. On reheating, the enthalpy of the 69-70 degrees C transition is dependent on the previous cooling rate. The DSC data provide clear evidence of conversions between metastable and stable forms. X-ray diffraction data recorded at 26, 75 and 93 degrees C show clearly that NLGS bilayer phases are present at all temperatures. The X-ray diffraction pattern at 75 degrees C shows a bilayer periodicity d = 65.4 A, and a number of sharp reflections in the wide-angle region indicative of a crystalline chain packing mode. This stable bilayer form converts to a liquid-crystal bilayer phase; at 93 degrees C, the bilayer periodicity d = 59.1 A, and a diffuse reflection at 1/4.6 A-1 is observed. The diffraction pattern at 22 degrees C represents a combination of the stable and metastable low-temperature bilayer forms. NLGS exhibits a complex pattern of thermotropic changes related to conversions between metastable (gel), stable (crystalline) and liquid-crystalline bilayer phases. The structure and

  3. Anomalous Hall effect in Fe/Gd bilayers

    KAUST Repository

    Xu, W. J.

    2010-04-01

    Non-monotonic dependence of anomalous Hall resistivity on temperature and magnetization, including a sign change, was observed in Fe/Gd bilayers. To understand the intriguing observations, we fabricated the Fe/Gd bilayers and single layers of Fe and Gd simultaneously. The temperature and field dependences of longitudinal resistivity, Hall resistivity and magnetization in these films have also been carefully measured. The analysis of these data reveals that these intriguing features are due to the opposite signs of Hall resistivity/or spin polarization and different Curie temperatures of Fe and Gd single-layer films. Copyright (C) EPLA, 2010

  4. Gramicidin-based fluorescence assay; for determining small molecules potential for modifying lipid bilayer properties

    NARCIS (Netherlands)

    Ingólfsson, Helgi I; Sanford, R Lea; Kapoor, Ruchi; Andersen, Olaf S

    2010-01-01

    Many drugs and other small molecules used to modulate biological function are amphiphiles that adsorb at the bilayer/solution interface and thereby alter lipid bilayer properties. This is important because membrane proteins are energetically coupled to their host bilayer by hydrophobic interactions.

  5. Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay

    NARCIS (Netherlands)

    Ingólfsson, Helgi I; Andersen, Olaf S

    2010-01-01

    Many drugs and other small molecules used to modulate biological function are amphiphiles that adsorb at the bilayer/solution interface and thereby alter lipid bilayer properties. This is important because membrane proteins are energetically coupled to their host bilayer by hydrophobic interactions.

  6. Phase Transition of MoS2 Bilayer Structures

    DEFF Research Database (Denmark)

    Pandey, Mohnish; Bothra, Pallavi; Pati, Swapan K.

    2016-01-01

    In the present study, using density functional calculations we have investigated a possible mechanism for the structural phase transition of the semiconducting bilayer 2H-MoS2 via lithiation. The results indicate that the addition of lithium to the bilayer 2H-MoS2 transforms the bilayer to a hete...

  7. Bridge Decomposition of Restriction Measures

    CERN Document Server

    Alberts, Tom

    2009-01-01

    Motivated by Kesten's bridge decomposition for two-dimensional self-avoiding walks in the upper half plane, we show that the conjectured scaling limit of the half-plane SAW, the SLE(8/3) process, also has an appropriately defined bridge decomposition. This continuum decomposition turns out to entirely be a consequence of the restriction property of SLE(8/3), and as a result can be generalized to the wider class of restriction measures. Specifically we show that the restriction hulls with index less than one can be decomposed into a Poisson Point Process of irreducible bridges in a way that is similar to Ito's excursion decomposition of a Brownian motion according to its zeros.

  8. Bridge Number and Conway Products

    OpenAIRE

    Blair, Ryan C.

    2007-01-01

    Schubert proved that, given a composite link $K$ with summands $K_{1}$ and $K_{2}$, the bridge number of $K$ satisfies the following equation: $$\\beta(K)=\\beta(K_{1})+\\beta(K_{2})-1.$$ In ``Conway Produts and Links with Multiple Bridge Surfaces", Scharlemann and Tomova proved that, given links $K_{1}$ and $K_{2}$, there is a Conway product $K_{1}\\times_{c}K_{2}$ such that $$\\beta(K_{1}\\times_{c} K_{2}) \\leq \\beta(K_{1}) + \\beta(K_{2}) - 1$$ In this paper, we define the generalized Conway prod...

  9. Optimum selection on bridge erection with floating crane in East China Sea Bridge and Hangzhou Bay Bridge

    Institute of Scientific and Technical Information of China (English)

    Shunquan Qin; Pu Zhou; Youheng Hua

    2004-01-01

    @@ Introduction With the rapid development of China′s economy, many bridges will be built over the Chinese coastal waters of Pacific Ocean. Among them, construction of East China Sea Bridge has been commenced in June 2001, and will be completed at the end of 2005, Hangzhou Bay Bridge was also started to construct in June 2003(Fig. 1). These two ultralong bridges are designed as twin expressway bridges standing side by side each carries a 3-lane one-way carriageway. The total width is 31.5m and 33.0m respectively. East China Sea Bridge starts from Nanhui District, Shanghai and extends to the Yangshan Deep Water Port Area, which is located at one of the Qiqu Islands. The total length of the bridge is about 31.0 km, in which 25 km are on the sea, and 22 km is in the unnavigable region. Hangzhou Bay Bridge across the mouth of Qiantang River.

  10. Nonlinear dynamics of bi-layered graphene sheet, double-walled carbon nanotube and nanotube bundle

    Science.gov (United States)

    Gajbhiye, Sachin O.; Singh, S. P.

    2016-05-01

    Due to strong van der Waals (vdW) interactions, the graphene sheets and nanotubes stick to each other and form clusters of these corresponding nanostructures, viz. bi-layered graphene sheet (BLGS), double-walled carbon nanotube (DWCNT) and nanotube bundle (NB) or ropes. This research work is concerned with the study of nonlinear dynamics of BLGS, DWCNT and NB due to nonlinear interlayer vdW forces using multiscale atomistic finite element method. The energy between two adjacent carbon atoms is represented by the multibody interatomic Tersoff-Brenner potential, whereas the nonlinear interlayer vdW forces are represented by Lennard-Jones 6-12 potential function. The equivalent nonlinear material model of carbon-carbon bond is used to model it based on its force-deflection relation. Newmark's algorithm is used to solve the nonlinear matrix equation governing the motion of the BLGS, DWCNT and NB. An impulse and harmonic excitations are used to excite these nanostructures under cantilevered, bridged and clamped boundary conditions. The frequency responses of these nanostructures are computed, and the dominant resonant frequencies are identified. Along with the forced vibration of these structures, the eigenvalue extraction problem of armchair and zigzag NB is also considered. The natural frequencies and corresponding mode shapes are extracted for the different length and boundary conditions of the nanotube bundle.

  11. Melittin-Induced Bilayer Leakage Depends on Lipid Material Properties: Evidence for Toroidal Pores

    OpenAIRE

    Allende, Daniel; Simon, S. A.; McIntosh, Thomas J.

    2004-01-01

    The membrane-lytic peptide melittin has previously been shown to form pores in lipid bilayers that have been described in terms of two different structural models. In the “barrel stave” model the bilayer remains more or less flat, with the peptides penetrating across the bilayer hydrocarbon region and aggregating to form a pore, whereas in the “toroidal pore” melittin induces defects in the bilayer such that the bilayer bends sharply inward to form a pore lined by both peptides and lipid head...

  12. Characterization of the Prokaryotic Sodium Channel NavSp Pore with a Microfluidic Bilayer Platform.

    Directory of Open Access Journals (Sweden)

    Shimul Chandra Saha

    Full Text Available This paper describes the use of a newly-developed micro-chip bilayer platform to examine the electrophysiological properties of the prokaryotic voltage-gated sodium channel pore (Na(vSp from Silicibacter pomeroyi. The platform allows up to 6 bilayers to be analysed simultaneously. Proteoliposomes were incorporated into suspended lipid bilayers formed within the microfluidic bilayer chips. The chips provide access to bilayers from either side, enabling the fast and controlled titration of compounds. Dose-dependent modulation of the opening probability by the channel blocking drug nifedipine was measured and its IC50 determined.

  13. Normal and Frictional Interactions between Liposome-Bearing Biomacromolecular Bilayers.

    Science.gov (United States)

    Gaisinskaya-Kipnis, Anastasia; Klein, Jacob

    2016-08-01

    Highly efficient lubricating boundary layers at biosurfaces such as cartilage have been proposed to comprise phospholipids complexed with biomacromolecules exposed at the surfaces. To gain insight into this, a systematic study on the normal and frictional forces between surfaces bearing a sequentially deposited model alginate-on-chitosan bilayer, bearing different adsorbed phosphatidylcholine (PC) liposomes, was carried out using a surface force balance. Structures of the resulting surface complexes were determined using atomic force microscopy (AFM) and cryo-scanning electron microscopy (cryo-SEM). The liposome/lipid-polymer complexes could maintain their integrity up to high pressures in terms of both normal and shear interactions between the surfaces, which were repeatable, reproducible, and revealed very low friction (coefficient of friction μ down to 10(-3)-10(-4), depending on the PC used) up to pressures of hundreds of atm. We attribute this remarkable lubrication capability ultimately to hydration lubrication acting at the hydrated phosphocholine headgroups of the PC lipids, either exposed at the liposome surfaces or through complexation with the polyelectrolyte bilayer. Values of μ, while low, were roughly an order of magnitude higher than for the same PC vesicles adsorbed on bare mica, a difference attributed to their lower density on the bilayer; the bilayer, however, stabilized the PC-vesicles far better than bare mica against rupture and shear at high compressions and sliding. PMID:27409248

  14. Negative terahertz conductivity in disordered graphene bilayers with population inversion

    International Nuclear Information System (INIS)

    The gapless energy band spectra make the structures based on graphene and graphene bilayer with the population inversion to be promising media for the interband terahertz (THz) lasing. However, a strong intraband absorption at THz frequencies still poses a challenge for efficient THz lasing. In this paper, we show that in the pumped graphene bilayer, the indirect interband radiative transitions accompanied by scattering of carriers by disorder can provide a substantial negative contribution to the THz conductivity (together with the direct interband transitions). In the graphene bilayer on high-κ substrates with point charged defects, these transitions substantially compensate the losses due to the intraband (Drude) absorption. We also demonstrate that the indirect interband contribution to the THz conductivity in a graphene bilayer with the extended defects (such as the charged impurity clusters) can surpass by several times the fundamental limit associated with the direct interband transitions, and the Drude conductivity as well. These predictions can affect the strategy of the graphene-based THz laser implementation

  15. Polydimethylsiloxane bilayer films with an embedded spontaneous curvature.

    Science.gov (United States)

    Egunov, A I; Korvink, J G; Luchnikov, V A

    2016-01-01

    Elastomer polydimethylsiloxane (PDMS) films with embedded in-plane gradient stress are created by making PDMS/(PDMS + silicone oil) crosslinked bilayers and extracting the oil in a suitable organic solvent bath. The collapse of the elastomer after oil extraction generates differential stress in the films that is manifested through their out-of-plane deformation. The curvature κ of narrow stripes of the bilayer, which is composed of layers of approximately equal thicknesses and elasticity moduli, is satisfactorily described by the simple relationship κ = 1.5δH(-1), where δ is the mechanical strain, and H is the total thickness of the bilayer. Curvature mapping of triangular PDMS plates reveals the existence of spherical and cylindrical types of deformation at different locations of the plates. Various 3D-shaped objects can be formed by the self-folding of appropriately designed 2D patterns that are cut from the films, or by nonuniform distribution of the collapsing layer. Thin PDMS bilayers with embedded stress roll up into microtubes of almost perfect cylindrical shape when released in a controlled manner from a substrate. PMID:26539638

  16. Topological entanglement entropy in bilayer quantum Hall systems

    OpenAIRE

    Chung, Myung-Hoon

    2013-01-01

    We calculate the topological entanglement entropy in bilayer quantum Hall systems, dividing the set of quantum numbers into four parts. This topological entanglement entropy allows us to draw a phase diagram in the parameter space of layer separation and tunneling amplitude. We perform the finite size scaling analysis of the topological entanglement entropy in order to see the quantum phase transition clearly.

  17. Lipid Bilayer Membrane Perturbation by Embedded Nanopores: A Simulation Study.

    Science.gov (United States)

    Garcia-Fandiño, Rebeca; Piñeiro, Ángel; Trick, Jemma L; Sansom, Mark S P

    2016-03-22

    A macromolecular nanopore inserted into a membrane may perturb the dynamic organization of the surrounding lipid bilayer. To better understand the nature of such perturbations, we have undertaken a systematic molecular dynamics simulation study of lipid bilayer structure and dynamics around three different classes of nanopore: a carbon nanotube, three related cyclic peptide nanotubes differing in the nature of their external surfaces, and a model of a β-barrel nanopore protein. Periodic spatial distributions of several lipid properties as a function of distance from the nanopore were observed. This was especially clear for the carbon nanotube system, for which the density of lipids, the bilayer thickness, the projection of lipid head-to-tail vectors onto the membrane plane, and lipid lateral diffusion coefficients exhibited undulatory behavior as a function of the distance from the surface of the channel. Overall, the differences in lipid behavior as a function of the nanopore structure reveal local adaptation of the bilayer structure and dynamics to different embedded nanopore structures. Both the local structure and dynamic behavior of lipids around membrane-embedded nanopores are sensitive to the geometry and nature of the outer surface of the macromolecule/molecular assembly forming the pore. PMID:26943498

  18. Pinning and switching of magnetic moments in bilayer graphene

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Eduardo V; Lopez-Sancho, M P; Vozmediano, M A H [Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, E-28049 Madrid (Spain)], E-mail: evcastro@icmm.csic.es, E-mail: pilar@icmm.csic.es, E-mail: vozmediano@icmm.csic.es

    2009-09-15

    We examine the magnetic properties of the localized states induced by lattice vacancies in bilayer graphene with an unrestricted Hartree-Fock calculation. We show that, with realistic values of the parameters and for experimentally accessible gate voltages, we can have magnetic switching between an unpolarized and a fully polarized system.

  19. Pinning and switching of magnetic moments in bilayer graphene

    International Nuclear Information System (INIS)

    We examine the magnetic properties of the localized states induced by lattice vacancies in bilayer graphene with an unrestricted Hartree-Fock calculation. We show that, with realistic values of the parameters and for experimentally accessible gate voltages, we can have magnetic switching between an unpolarized and a fully polarized system.

  20. Super-Sensitive and Robust Biosensors from Supported Polymer Bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Paxton, Walter F. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    Biological organisms are potentially the most sensitive and selective biological detection systems known, yet we are currently severely limited in our ability to exploit biological interactions in sensory devices, due in part to the limited stability of biological systems and derived materials. This proposal addresses an important aspect of integrating biological sensory materials in a solid state device. If successful, such technology could enable entirely new classes of robust biosensors that could be miniaturized and deployed in the field. The critical aims of the proposed work were 1) the calibration of a more versatile approach to measuring pH, 2) the use of this method to monitor pH changes caused by the light-induced pumping of protons across vesicles with bacteriorhodopsin integrated into the membranes (either polymer or lipid); 3) the preparation of bilayer assemblies on platinum surfaces; 4) the enhanced detection of lightinduced pH changes driven by bR-loaded supported bilayers. I have developed a methodology that may enable that at interfaces and developed a methodology to characterize the functionality of bilayer membranes with reconstituted membrane proteins. The integrity of the supported bilayer films however must be optimized prior to the full realization of the work originally envisioned in the original proposal. Nevertheless, the work performed on this project and the encouraging results it has produced has demonstrated that these goals are challenging yet within reach.

  1. Kinetics of domain registration in multicomponent lipid bilayer membranes

    DEFF Research Database (Denmark)

    Sornbundit, K.; Modchang, C.; Triampo, W.;

    2014-01-01

    The kinetics of registration of lipid domains in the apposing leaflets of symmetric bilayer membranes is investigated via systematic dissipative particle dynamics simulations. The decay of the distance between the centres of mass of the domains in the apposing leaflets is almost linear during early...

  2. Phase behavior of pure lipid bilayers with mismatch interactions

    DEFF Research Database (Denmark)

    Zhang, Zhengping; Laradji, Mohamed; Guo, Hong;

    1992-01-01

    Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but c...

  3. The lipid bilayer membrane and its interactions with additives.

    NARCIS (Netherlands)

    Meijer, L.A.

    1994-01-01

    The aim of this study was to make accurate predictions on the interaction of biologically relevant molecules with lipid bilayer membranes. We emphasised on the partitioning of these molecules between the membrane phase, and the aqueous phase quantified by the partition coefficient. To make detailed

  4. Dynamics and instabilities of lipid bilayer membrane shapes.

    Science.gov (United States)

    Shi, Zheng; Baumgart, Tobias

    2014-06-01

    Biological membranes undergo constant shape remodeling involving the formation of highly curved structures. The lipid bilayer represents the fundamental architecture of the cellular membrane with its shapes determined by the Helfrich curvature bending energy. However, the dynamics of bilayer shape transitions, especially their modulation by membrane proteins, and the resulting shape instabilities, are still not well understood. Here, we review in a unifying manner several theories that describe the fluctuations (i.e. undulations) of bilayer shapes as well as their local coupling with lipid or protein density variation. The coupling between local membrane curvature and lipid density gives rise to a 'slipping mode' in addition to the conventional 'bending mode' for damping the membrane fluctuation. This leads to a number of interesting experimental phenomena regarding bilayer shape dynamics. More importantly, curvature-inducing proteins can couple with membrane shape and eventually render the membrane unstable. A criterion for membrane shape instability is derived from a linear stability analysis. The instability criterion reemphasizes the importance of membrane tension in regulating the stability and dynamics of membrane geometry. Recent progresses in understanding the role of membrane tension in regulating dynamical cellular processes are also reviewed. Protein density is emphasized as a key factor in regulating membrane shape transitions: a threshold density of curvature coupling proteins is required for inducing membrane morphology transitions. PMID:24529968

  5. Plasmons in metallic monolayer and bilayer transition metal dichalcogenides

    DEFF Research Database (Denmark)

    Andersen, Kirsten; Thygesen, Kristian S.

    2013-01-01

    We study the collective electronic excitations in metallic single-layer and bilayer transition metal dichalcogenides (TMDCs) using time dependent density functional theory in the random phase approximation. For very small momentum transfers (below q≈0.02 Å−1), the plasmon dispersion follows the √q...

  6. Interaction of gramicidin with DPPC/DODAB bilayer fragments.

    Science.gov (United States)

    Carvalho, Camilla A; Olivares-Ortega, Constanza; Soto-Arriaza, Marco A; Carmona-Ribeiro, Ana M

    2012-12-01

    The interaction between the antimicrobial peptide gramicidin (Gr) and dipalmitoylphosphatidylcholine (DPPC)/dioctadecyldimethylammonium bromide (DODAB) 1:1 large unilamellar vesicles (LVs) or bilayer fragments (BFs) was evaluated by means of several techniques. The major methods were: 1) Gr intrinsic fluorescence and circular dichroism (CD) spectroscopy; 2) dynamic light scattering for sizing and zeta-potential analysis; 3) determination of the bilayer phase transition from extrinsic fluorescence of bilayer probes; 4) pictures of the dispersions for evaluation of coloidal stability over a range of time and NaCl concentration. For Gr in LVs, the Gr dimeric channel conformation is suggested from: 1) CD and intrinsic fluorescence spectra similar to those in trifluoroethanol (TFE); 2) KCl or glucose permeation through the LVs/Gr bilayer. For Gr in BFs, the intertwined dimeric, non-channel Gr conformation is evidenced by CD and intrinsic fluorescence spectra similar to those in ethanol. Both LVs and BFs shield Gr tryptophans against quenching by acrylamide but the Stern-Volmer quenching constant was slightly higher for Gr in BFs confirming that the peptide is more exposed to the water phase in BFs than in LVs. The DPPC/DODAB/Gr supramolecular assemblies may predict the behavior of other antimicrobial peptides in assemblies with lipids. PMID:22960286

  7. Negative terahertz conductivity in disordered graphene bilayers with population inversion

    Energy Technology Data Exchange (ETDEWEB)

    Svintsov, D. [Laboratory of Nanooptics and Plasmonics, Moscow Institute of Physics and Technology, Dolgoprudny 141700 (Russian Federation); Otsuji, T.; Ryzhii, V., E-mail: v-ryzhii@riec.tohoku.ac.jp [Research Institute of Electrical Communication, Tohoku University, Sendai 980-8577 (Japan); Mitin, V. [Research Institute of Electrical Communication, Tohoku University, Sendai 980-8577 (Japan); Department of Electrical Engineering, University at Buffalo, SUNY, Buffalo, New York 1460-1920 (United States); Shur, M. S. [Departments of Electrical, Electronics, and Systems Engineering and Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

    2015-03-16

    The gapless energy band spectra make the structures based on graphene and graphene bilayer with the population inversion to be promising media for the interband terahertz (THz) lasing. However, a strong intraband absorption at THz frequencies still poses a challenge for efficient THz lasing. In this paper, we show that in the pumped graphene bilayer, the indirect interband radiative transitions accompanied by scattering of carriers by disorder can provide a substantial negative contribution to the THz conductivity (together with the direct interband transitions). In the graphene bilayer on high-κ substrates with point charged defects, these transitions substantially compensate the losses due to the intraband (Drude) absorption. We also demonstrate that the indirect interband contribution to the THz conductivity in a graphene bilayer with the extended defects (such as the charged impurity clusters) can surpass by several times the fundamental limit associated with the direct interband transitions, and the Drude conductivity as well. These predictions can affect the strategy of the graphene-based THz laser implementation.

  8. New dielectric relaxation in a bilayered fluid smectic phase

    OpenAIRE

    Benguigui, L.; Hardouin, F.

    1984-01-01

    We present dielectric measurements of the « DB8Cl » cyano compound which exhibits a Smectic A2 → Smectic C2 → Smectic ? sequence of bilayered fluid smectic phases. In particular a new perpendicular relaxation is observed in the S? which we interpret as indicative of a dipole ordering. A simplified model taking this result into account is proposed.

  9. The effects of globotriaosylceramide tail saturation level on bilayer phases

    DEFF Research Database (Denmark)

    Pezeshkian, Weria; Chaban, Vitaly V; Johannes, Ludger;

    2015-01-01

    Globotriaosylceramide (Gb3) is a glycosphingolipid present in the plasma membrane that is the natural receptor of the bacterial Shiga toxin. The unsaturation level of Gb3 acyl chains has a drastic impact on lipid bilayer properties and phase behaviour, and on many Gb3-related cellular processes. ...... of sphingomyelin lipids and (3) At higher Gb3 concentrations, U-Gb3 mixes better with dioleoylphosphatidylcholine than S-Gb3. Our simulations also provide the first molecular level structural model of Gb3 in membranes.......Globotriaosylceramide (Gb3) is a glycosphingolipid present in the plasma membrane that is the natural receptor of the bacterial Shiga toxin. The unsaturation level of Gb3 acyl chains has a drastic impact on lipid bilayer properties and phase behaviour, and on many Gb3-related cellular processes...... of the Gb3 concentration and its acyl chain saturation on the phase behaviour of a mixed bilayer of dioleoylphosphatidylcholine and Gb3. The simulation results show that: (1) the Gb3 acyl chains (longer tails) from one leaflet interdigitate into the opposing leaflet and lead to significant bilayer...

  10. An Expert System for Concrete Bridge Management

    DEFF Research Database (Denmark)

    Brito, J. de; Branco, F. A.; Thoft-Christensen, Palle;

    1997-01-01

    The importance of bridge repair versus new bridge construction has risen in recent decades due to high deterioration rates that have been observed in these structures. Budgets both for building new bridges and keeping the existing ones are always limited. To help rational decision-making, bridge ...... information complemented by a knowledge-based interactive system, BRIDGE-1. To optimize management strategies at the headquarters, the BRIDGE-2 module was implemented, including three submodules: inspection strategy, maintenance and repair....... management systems are presently being implemented by bridge authorities in several countries. The prototype of an expert system for concrete bridge management is presented in this paper, with its functionality relying on two modules. The inspection module relies on a periodic acquisition of field...

  11. Intercellular bridges in vertebrate gastrulation.

    Directory of Open Access Journals (Sweden)

    Luca Caneparo

    Full Text Available The developing zebrafish embryo has been the subject of many studies of regional patterning, stereotypical cell movements and changes in cell shape. To better study the morphological features of cells during gastrulation, we generated mosaic embryos expressing membrane attached Dendra2 to highlight cellular boundaries. We find that intercellular bridges join a significant fraction of epiblast cells in the zebrafish embryo, reaching several cell diameters in length and spanning across different regions of the developing embryos. These intercellular bridges are distinct from the cellular protrusions previously reported as extending from hypoblast cells (1-2 cellular diameters in length or epiblast cells (which were shorter. Most of the intercellular bridges were formed at pre-gastrula stages by the daughters of a dividing cell maintaining a membrane tether as they move apart after mitosis. These intercellular bridges persist during gastrulation and can mediate the transfer of proteins between distant cells. These findings reveal a surprising feature of the cellular landscape in zebrafish embryos and open new possibilities for cell-cell communication during gastrulation, with implications for modeling, cellular mechanics, and morphogenetic signaling.

  12. Architectural engineering of FRP bridges

    OpenAIRE

    Smits, J.E.P.

    2014-01-01

    This paper deals with the use of Fibre Reinforced Polymers (FRP's) in architectural and structural bridge design. The challenges and opportunities that come with this relatively new material are discussed. An inventory is made of recent engineers' solutions in FRP, followed by a discussion on architectural application of FRP's derived from the authors architectural practice.

  13. Artropathies that produce osseous bridges

    International Nuclear Information System (INIS)

    In this paper, it is reviewed the most common artropathies that are presented with osseous bridging, with emphasis in the radiological finding of the spine. Also, it's showed other different radiological finding that can help in the differential diagnosis of this disease, such us the sacroilitis in the ankylosing spondylitis or the osteolysis in the psoriatic arthritis

  14. Bridge Aesthetics and Structural Honesty

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    In bridges the overall form must be chosen with due respect to the transmission of forces if efficient structures shall be created, The design must therefore be governed by experienced structural engineers - in some cases assisted by aesthetic advisers on specific issues. Some basic requirements ...

  15. Formation and finite element analysis of tethered bilayer lipid structures.

    Science.gov (United States)

    Kwak, Kwang Joo; Valincius, Gintaras; Liao, Wei-Ching; Hu, Xin; Wen, Xuejin; Lee, Andrew; Yu, Bo; Vanderah, David J; Lu, Wu; Lee, L James

    2010-12-01

    Rapid solvent exchange of an ethanolic solution of diphytanoyl phosphatidylcholine (DPhyPC) in the presence of a mixed self-assembled monolayer (SAM) [thiolipid/β-mercaptoethanol (βME) (3/7 mol/mol) on Au] shows a transition from densely packed tethered bilayer lipid membranes [(dp)tBLMs], to loosely packed tethered bilayer lipid membranes [(lp)tBLMs], and tethered bilayer liposome nanoparticles (tBLNs) with decreasing DPhyPC concentration. The tethered lipidic constructs in the aqueous medium were analyzed by atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS). Finite element analysis (FEA) was applied to interpret spectral EIS features without referring to equivalent circuit modeling. Using structural data obtained earlier from neutron reflectometry and dielectric constants of lipid bilayers, we reproduced experimentally observed features of the electrochemical impedance (EI) spectra of complex surface constructs involving small pinhole defects, large membrane-free patches, and bound liposomes. We demonstrated by FEA that highly insulating (dp)tBLMs with low-defect density exhibit EI spectra in the shape of a perfect semicircle with or without low-frequency upward "tails" in the Cole-Cole representation. Such EI spectra were observed at DPhyPC concentrations of >5 × 10(-3) mol L(-1). While AFM was not able to visualize very small lateral defects in such films, EI spectra unambiguously signaled their presence by increased low frequency "tails". Using FEA we demonstrate that films with large diameter visible defects (>25 nm by AFM) produce EI spectral features consisting of two semicircles of comparable size. Such films were typically obtained at DPhyPC concentrations of FEA revealed that, to account for these EI features for bound liposome systems (50-500 nm diameter), one needs to assume much lower tBLM conductivities of the submembrane space, which separates the electrode surface and the phospholipid bilayer. Alternatively, FEA

  16. Regulation of membrane protein function by lipid bilayer elasticity—a single molecule technology to measure the bilayer properties experienced by an embedded protein

    DEFF Research Database (Denmark)

    Lundbæk, Jens August

    2008-01-01

    protein and the host lipid bilayer provide an energetic coupling, whereby protein function can be regulated by the bilayer elasticity. The feasibility of this ‘hydrophobic coupling mechanism’ has been demonstrated using the gramicidin channel, a model membrane protein, in planar lipid bilayers. Using...... voltage-dependent sodium channels, N-type calcium channels and GABAA receptors, it has been shown that membrane protein function in living cells can be regulated by amphiphile induced changes in bilayer elasticity. Using the gramicidin channel as a molecular force transducer, a nanotechnology to measure...

  17. Transition Slabs of Integral Abutment Bridges

    OpenAIRE

    Dreier, Damien; Muttoni, Aurelio; BURDET, Olivier

    2011-01-01

    Over the past decades, an increasing number of bridges with integral abutment have been built in Switzerland. This type of bridge offers various advantages over standard bridges with abutments, equipped with expansion joints and bearings that require regular inspection and maintenance. One main concern of integral abutment bridges is related to the soil-structure interaction, in particular between the transition slab and the embankment. To avoid any expansion joints, transition slabs are dire...

  18. Dynamic identification of paradela historic railway bridge

    OpenAIRE

    Ramos, Luís F.; Valente, Isabel; Guimarães, Paulo; Vazquez, Kevin; Lourenço, Paulo B.

    2013-01-01

    Paradela Bridge is a metallic bridge located along the bank of the Tua River in northern Portugal. While the bridge is not currently in service, its structure is representative of many metallic truss structures built across the country between the 19th and the 20th century. The construction of the Paradela Bridge was completed in 1886 and served for about 120 years connecting northern Portugal. Tua Line belongs to the Douro area that UNESCO recently declared as world heritage. This work acqui...

  19. Path transformations of first passage bridges

    OpenAIRE

    Bertoin, Jean

    2003-01-01

    We define the first passage bridge from 0 to $\\lambda$ as the Brownian motion on the time interval $[0,1]$ conditioned to first hit $\\lambda$ at time 1. We show that this process may be related to the Brownian bridge, the Bessel bridge or the Brownian excursion via some path transformations, the main one being an extension of Vervaat's transformation. We also propose an extension of these results to certain bridges with cyclically exchangeable increments.

  20. Bilayer Approaches for Nanoparticle Phase Transfer

    Science.gov (United States)

    Kini, Gautam Chandrakanth

    Nanoparticles (NPs) are often synthesized in organic solvents due to advantages of superior size and shape control obtainable in a non-polar environment. However, many applications featuring NPs require them to be in aqueous media. To transfer NPs from oil to water, surfactants with amphiphilic (hydrophobic and hydrophilic) groups have been widely used. A popular phase-transfer approach involves formation of oil-in-water emulsions upon which the oil storing the NPs is boiled off. In the process, surfactants form bilayers with hydrophobic groups on the NPs rendering them water-dispersible. This transfer route however is limited in that NPs aggregate to form clusters which results in poor colloidal stability and for the specific case of quantum dots (QDs), adversely impacts optical properties. It has ever since remained a challenge to devise approaches that transfer NPs from oil to water as single particles without compromising NP stability and properties. We have discovered that by simple addition of salt to water during the step of emulsion formation, NP transfer efficiency can be greatly enhanced in "salty-micelles" of surfactants. The strength of this approach lies in its simplicity and generic nature in that the transfer scheme is valid for different NP, surfactant and salt types. Using a model system with cadmium selenide (CdSe) QDs as NPs, Aerosol-OT (AOT) as the surfactant and NaCl as the salt in water, we found >90% of CdSe QDs transferred in salty-micelles of AOT which was significantly higher than the 45-55% QDs that transferred in deionized-water (DI-water) micelles of AOT. In the salty-micelle environment, QDs were found to exist predominantly as single NPs with narrow size distribution, as established by light scattering, analytical ultracentrifugation and electron microscopy. The effects of salt were in lowering aqueous solubility of AOT through "salting-out" action and in screening repulsions between like-charged head groups of AOT molecules

  1. Amphiphile regulation of ion channel function by changes in the bilayer spring constant

    DEFF Research Database (Denmark)

    Lundbæk, Jens August; Koeppe, R.E.; Andersen, Oluf Sten

    2010-01-01

    predicted from measurements of isolated changes in such properties. Thus, the bilayer contribution to the promiscuous regulation of membrane proteins by drugs and other amphiphiles remains unknown. To overcome this problem, we use gramicidin A (gA) channels as molecular force probes to measure the net...... altering the energetic cost (Delta G(bilayer)) of bilayer deformations associated with protein conformational changes that involve the protein-bilayer interface. But amphiphiles have complex effects on the physical properties of lipid bilayers, meaning that the net change in Delta G(bilayer) cannot be......-dependent sodium channels in living cells. The use of gA channels as molecular force probes provides a tool for quantitative, predictive studies of bilayer-mediated regulation of membrane protein function by amphiphiles....

  2. 47 CFR 80.331 - Bridge-to-bridge communication procedure.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bridge-to-bridge communication procedure. 80..., Alarm, Urgency and Safety Procedures § 80.331 Bridge-to-bridge communication procedure. (a) Vessels... position). I plan to (give proposed course of action). Over. (3) (Coast station), this is (vessel's...

  3. Cholesterol enhances surface water diffusion of phospholipid bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Chi-Yuan; Kausik, Ravinath; Han, Songi, E-mail: songi@chem.ucsb.edu [Department of Chemistry and Biochemistry and Materials Research Laboratory, University of California, Santa Barbara, California 93106 (United States); Olijve, Luuk L. C. [Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven (Netherlands)

    2014-12-14

    Elucidating the physical effect of cholesterol (Chol) on biological membranes is necessary towards rationalizing their structural and functional role in cell membranes. One of the debated questions is the role of hydration water in Chol-embedding lipid membranes, for which only little direct experimental data are available. Here, we study the hydration dynamics in a series of Chol-rich and depleted bilayer systems using an approach termed {sup 1}H Overhauser dynamic nuclear polarization (ODNP) NMR relaxometry that enables the sensitive and selective determination of water diffusion within 5–10 Å of a nitroxide-based spin label, positioned off the surface of the polar headgroups or within the nonpolar core of lipid membranes. The Chol-rich membrane systems were prepared from mixtures of Chol, dipalmitoyl phosphatidylcholine and/or dioctadecyl phosphatidylcholine lipid that are known to form liquid-ordered, raft-like, domains. Our data reveal that the translational diffusion of local water on the surface and within the hydrocarbon volume of the bilayer is significantly altered, but in opposite directions: accelerated on the membrane surface and dramatically slowed in the bilayer interior with increasing Chol content. Electron paramagnetic resonance (EPR) lineshape analysis shows looser packing of lipid headgroups and concurrently tighter packing in the bilayer core with increasing Chol content, with the effects peaking at lipid compositions reported to form lipid rafts. The complementary capability of ODNP and EPR to site-specifically probe the hydration dynamics and lipid ordering in lipid membrane systems extends the current understanding of how Chol may regulate biological processes. One possible role of Chol is the facilitation of interactions between biological constituents and the lipid membrane through the weakening or disruption of strong hydrogen-bond networks of the surface hydration layers that otherwise exert stronger repulsive forces, as reflected in

  4. Cholesterol enhances surface water diffusion of phospholipid bilayers

    Science.gov (United States)

    Cheng, Chi-Yuan; Olijve, Luuk L. C.; Kausik, Ravinath; Han, Songi

    2014-12-01

    Elucidating the physical effect of cholesterol (Chol) on biological membranes is necessary towards rationalizing their structural and functional role in cell membranes. One of the debated questions is the role of hydration water in Chol-embedding lipid membranes, for which only little direct experimental data are available. Here, we study the hydration dynamics in a series of Chol-rich and depleted bilayer systems using an approach termed 1H Overhauser dynamic nuclear polarization (ODNP) NMR relaxometry that enables the sensitive and selective determination of water diffusion within 5-10 Å of a nitroxide-based spin label, positioned off the surface of the polar headgroups or within the nonpolar core of lipid membranes. The Chol-rich membrane systems were prepared from mixtures of Chol, dipalmitoyl phosphatidylcholine and/or dioctadecyl phosphatidylcholine lipid that are known to form liquid-ordered, raft-like, domains. Our data reveal that the translational diffusion of local water on the surface and within the hydrocarbon volume of the bilayer is significantly altered, but in opposite directions: accelerated on the membrane surface and dramatically slowed in the bilayer interior with increasing Chol content. Electron paramagnetic resonance (EPR) lineshape analysis shows looser packing of lipid headgroups and concurrently tighter packing in the bilayer core with increasing Chol content, with the effects peaking at lipid compositions reported to form lipid rafts. The complementary capability of ODNP and EPR to site-specifically probe the hydration dynamics and lipid ordering in lipid membrane systems extends the current understanding of how Chol may regulate biological processes. One possible role of Chol is the facilitation of interactions between biological constituents and the lipid membrane through the weakening or disruption of strong hydrogen-bond networks of the surface hydration layers that otherwise exert stronger repulsive forces, as reflected in faster

  5. Structure and properties of mixed-chain phosphatidylcholine bilayers.

    Science.gov (United States)

    Shah, J; Sripada, P K; Shipley, G G

    1990-05-01

    The structural and thermotropic properties of the hydrated mixed-chain phosphatidylcholines (PCs), C(8):C(18)-PC and C(10):C(18)-PC, have been studied by X-ray diffraction and differential scanning calorimetry. For fully hydrated C(8):C(18)-PC, the reversible chain melting transition is observed at 9.9 degrees C (delta H = 7.3 kcal/mol). X-ray diffraction at 0 degrees C (below the chain melting transition) shows a small bilayer repeat distance, d = 51.0 A, and a sharp, symmetric wide-angle reflection at 4.1 A, characteristic of a mixed interdigitated bilayer gel phase [see McIntosh, T. J., Simon, S. A., Ellington, J. C., Jr., & Porter, N. A. (1984) Biochemistry 23, 4038-4044; Hui, S. W., Mason, J. T., & Huang, C. (1984) Biochemistry 23, 5570-5577]. At 30 degrees C (above the chain melting transition), a diffuse band is observed at 4.5 A characteristic of an L alpha phase but with an increased bilayer periodicity, d = 61 A. Both the calculated lipid bilayer thickness (d1) and that determined directly from electron density profiles (dp-p) show unusual increases as a consequence of chain melting. In contrast, fully hydrated C(10):C(18)-PC shows an asymmetric endothermic transition at 11.8 degrees C. Below the chain melting transition, two lamellar phases are present, corresponding to coexisting interdigitated (d = 52.3 A) and noninterdigitated (d = 62.5 A) bilayer gel phases. The relative amounts of these phases depend upon the low-temperature incubation and/or hydration conditions, suggesting conversions, albeit kinetically complex, between metastable, and stable phases. The different behavior of C(8):C(18)-PC and C(10):C(18)-PC, as well as their positional isomers, is rationalized in terms of the molecular conformation of PC. PMID:2361142

  6. Bridge spectra of iterated torus knots

    OpenAIRE

    Zupan, Alexander

    2013-01-01

    We determine the set of all genus g bridge numbers of many iterated torus knots, listing these numbers in a sequence called the bridge spectrum. In addition, we prove a structural lemma about the decomposition of a strongly irreducible bridge surface induced by cutting along a collection of essential surfaces.

  7. Two bridges with composite prestressed tension chord

    OpenAIRE

    Muttoni, Aurelio

    2002-01-01

    the bridges over the river Capriasca (1996) and over the river Ticino (1997) are characterised by the application of an innovative structural system. The central part of the main span of both bridges is constituted by the bridge concrete deck with two longitudinal stiffening girders, constituted by polygonal steel members that contain two prestressing tendons each.

  8. Stabilizer for seismically exposed bridge cranes

    International Nuclear Information System (INIS)

    The invention concerns a stabilizer for seismically exposed bridge cranes in reactor buildings. The trolley and the crane bridge are fitted with the stabilizer consisting of a bipartite safety catch which is connected with a joint and able to take up the vertical loads during an earthquake. This stabilizer is suitable for all kinds of bridge cranes operated in seismically active regions

  9. Remediation: Higher Education's Bridge to Nowhere

    Science.gov (United States)

    Complete College America, 2012

    2012-01-01

    The intentions were noble. It was hoped that remediation programs would be an academic bridge from poor high school preparation to college readiness. Sadly, remediation has become instead higher education's "Bridge to Nowhere." This broken remedial bridge is travelled by some 1.7 million beginning students each year, most of whom will…

  10. Comprehensive Real-Time Bridge Health Monitoring System of Tongtai Bridge

    OpenAIRE

    Lei Su-su; Gao Yong-tao; Pan Dan-guang

    2015-01-01

    Tongtai Bridge is the world’s largest suspension curve-girder-skew-arch bridge, which is located in Zhangjiakou, China. The understanding of mechanics characteristics is limited to such complex bridges, so it is necessary to establish reliable health monitoring system to investigate the static and dynamic responses and monitor the safety of the bridge. A comprehensive real-time bridge health monitoring system is establish, which includes four aspects: sensor system, data acquisition and trans...

  11. Theory of water and charged liquid bridges.

    Science.gov (United States)

    Morawetz, K

    2012-08-01

    The phenomenon of liquid bridge formation due to an applied electric field is investigated. A solution of a charged catenary is presented, which allows one to determine the static and dynamical stability conditions where charged liquid bridges are possible. The creeping height, the bridge radius and length, as well as the shape of the bridge are calculated showing an asymmetric profile, in agreement with observations. The flow profile is calculated from the Navier-Stokes equation leading to a mean velocity, which combines charge transport with neutral mass flow and which describes recent experiments on water bridges. PMID:23005849

  12. New Concept for Durable Concrete Bridges

    OpenAIRE

    Damek, Marek

    2015-01-01

    This master’s thesis covers the design of a post-tensioned concrete bridge in Trondheim municipality in Norway, in collaboration with Statens vegvesen (SVV). The concept of the bridge is inspired by Egg-Graben-Brücke in Austria, which was designed and built without steel reinforcement in the bridge deck. The idea is to eliminate steel reinforcement which can corrode in the bridge deck. The total length of the bridge is 73 meters and it is divided into 3 spans. The crosssection ...

  13. Noise Considerations in Resistance Bridges

    DEFF Research Database (Denmark)

    Diamond, Joseph M.

    1963-01-01

    thermometry, where the noise in the unknown resistor will predominate strongly. An impedance step-up device (transformer or tuned circuit) is valuable in raising the bridge signal and noise level above the noise of the first amplifier tube. However, as the step-up ratio is increased, two counterfactors appear......, namely, noise in the loss resistance of the step-up device, and grid current noise. There is therefore an optimum step-up ratio, which has been found. The step-up device is permitted to have a different temperature from the unknown and standard resistors, to evaluate the advantage of cooling it....... With certain assumptions about the noise and grid current of the first tube it is found that the equivalent temperature of a unity ratio (Mueller) bridge used for liquid helium measurements may be 400°K....

  14. Full-bridge capacitive extensometer

    Science.gov (United States)

    Peters, Randall D.

    1993-08-01

    Capacitive transducers have proven to be very effective sensors of small displacements, because of inherent stability and noninvasive high resolution. The most versatile ones have been those of a differential type, in which two elements are altered in opposite directions in response to change of the system parameter being monitored. Oftentimes, this differential pair has been incorporated into a bridge circuit, which is a useful means for employing synchronous detection to improve signal to noise ratios. Unlike previous differential capacitive dilatometers which used only two active capacitors, the present sensor is a full-bridge type, which is well suited to measuring low-level thermal expansions. This analog sensor is capable of 0.1 μm resolution anywhere within a range of several centimeters, with a linearity of 0.1%. Its user friendly output can be put on a strip chart recorder or directed to a computer for sophisticated data analysis.

  15. The radiography of Swaythling Bridge

    International Nuclear Information System (INIS)

    The particular application of high energy radiography described in this paper was developed by the Harwell Nondestructive Testing Centre (NDTC) under the sponsorship of Radiation Dynamics Ltd, (RDL) who manufacture the 'Super-X' linear accelerator (Linac) used for the work. An initial evaluation determined the limits for thickness of concrete structures which could be radiographed with the linac under practical conditions. The technique was then applied to carry out a test on a bridge carrying a main trunk road over a small river in an urban environment. A situation which demanded the utmost care in deciding safety parameters and minimal disturbance to the surrounding environment. The safety parameters were defined by the Environmental and Medical Sciences Division of AERE Harwell (EMSc). The test was successfully carried out, within all the control parameters laid down beforehand, and very important engineering data were obtained for the Bridge Engineering Departments of Hampshire County Council and Southampton City Council. (author)

  16. Bridging history and social psychology

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre; Yamamoto, Koji

    2012-01-01

    This special issue aims to bridge history and social psychology by bringing together historians and social psychologists in an exercise of reading and learning from each other’s work. This interdisciplinary exercise is not only timely but of great importance for both disciplines. Social psycholog......This special issue aims to bridge history and social psychology by bringing together historians and social psychologists in an exercise of reading and learning from each other’s work. This interdisciplinary exercise is not only timely but of great importance for both disciplines. Social...... psychologists can benefit from engaging with historical sources by being able to contextualise their findings and enrich their theoretical models. It is not only that all social and psychological phenomena have a history but this history is very much part of present-day and future developments. On the other...

  17. 2015 Bridge Inspection ERC Training

    OpenAIRE

    Dougherty, Merril

    2015-01-01

    This presentation will discuss recent changes to the County Bridge Inspection Program from the perspective of both the FHWA and INDOT. We will also discuss the responsibilities of the local public agency’s (LPA’s) employee in responsible charge (ERC) with respect to managing this program. As this course is a yearly requirement, all county ERCs are encouraged to attend. Pre-registering is strongly encouraged by e-mailing your contact information to .

  18. Severe ASR damaged concrete bridges

    DEFF Research Database (Denmark)

    Antonio Barbosa, Ricardo; Gustenhoff Hansen, Søren

    2015-01-01

    Technical University of Denmark (DTU) and University of Southern Denmark (SDU) have conducted several full-scale experiments with severe ASR deteriorated bridges. This paper presents few and preliminary results from both the shear tests and the measuring of the material properties. The shear tests...... show that the shear capacity is almost unaffected of ASR despite significant reduction in compressive concrete strength. Furthermore, measurements show a significant tensile reinforcement strain developed due to ASR expansion....

  19. Stability of Axisymmetric Liquid Bridges

    CERN Document Server

    Rubinstein, Boris

    2016-01-01

    We study stability of axisymmetric liquid bridges between two axisymmetric solid bodies in the absence of gravity under arbitrary asymmetric perturbations which are expanded into a set of angular Fourier modes. We determine the stability region boundary for every angular mode in case of both fixed and free contact lines. Application of this approach allows us to demonstrate existence of stable convex nodoid menisci between two spheres.

  20. The Bridge Program - Participant Perspectives

    OpenAIRE

    Rönnqvist, Riitta; Hakonen, Anu; Vartiainen, Matti

    2015-01-01

    The Nokia Bridge Program was established in summer 2011 in order to "make the best of the restructuring: create meaningful opportunities for individuals and local economies impacted by workforce reductions" and to "assist individuals in re-employment". This document reports whether and how the program helped individuals avoid the known negative effects of job loss and find meaningful re-employment. The document also reports how affected employees formed perceptions about Nokia´s fairness and ...

  1. Inspection Strategies for Concrete Bridges

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    In this paper an optimal inspection strategy for concrete bridges based on periodic routine and detailed inspections is presented. The failure mode considered is corrosion of the reinforcement due to chlorides. A simple modelling of the corrosion and of the inspection strategy is presented. The...... optimal inspection strategy is determined from an optimization problem, where the design variables are time intervals between detailed inspections and the concrete cover. The strategy is illustrated on a simple structure, namely a reinforced concrete beam....

  2. Adsorption of polymeric brushes: Bridging

    Science.gov (United States)

    Johner, Albert; Joanny, Jean-François

    1992-04-01

    We study the adsorption of grafted polymer layers on a planar surface parallel to the grafting surface. The layer consists of two types of chains: nonadsorbed chains with a free end and adsorbed chains forming bridges between the two plates. In the limit of strong adsorption a dead zone exists in the vicinity of the adsorbing plate; its size increases with the adsorption strength. Two adsorption mechanisms are possible: adsorption of the last monomer only and adsorption of all the monomers. In both cases the adsorption regimes at equilibrium (when no external force acts on the plates) are discussed within the framework of the self-consistent mean-field theory. We also give scaling laws taking into account excluded volume correlations. Finally, we consider situations where a finite external force, either tangential or normal to the plates, is applied on the adsorbing plate. Pulling and tangential forces both reduce the fraction of bridges and eventually lead to rupture, whereas compressional forces favor bridging. For normal forces, force vs distance profiles between planes and crossed cylinders are given.

  3. Halliburton Composite Bridge Plug Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Starbuck, J.M.; Luttrell, C.R.; Aramayo, G.

    2005-01-15

    The overall objectives of this CRADA were to assist Halliburton in analyzing a composite bridge plug and to determine why their original design was failing in the field. In Phase 1, finite element analyses were done on the original composite slip design and several alternative designs. The composite slip was the component in the bridge plug that was failing. The finite element code ABAQUS was used for these calculations and I-DEAS was used as the pre- and post-processor in the analyses. Several different designs and materials were analyzed and recommendations were made towards improving the design. In Phase 2, the objective was to develop finite element models that would accurately represent the deformations in the entire all-composite 4-1/2' diameter bridge plug assembly. The finite element code LS-DYNA was used and the results from this effort were intended to expand Halliburton's composite design and analysis capabilities with regard to developing future composite components for downhole tools. In addition to the finite element modeling, this effort involved the utilization of micromechanics to determine the necessary composite material properties that were needed as input for finite element codes.

  4. The Alzheimer's disease Aβ peptide binds to the anionic DMPS lipid bilayer.

    Science.gov (United States)

    Lockhart, Christopher; Klimov, Dmitri K

    2016-06-01

    We have applied isobaric-isothermal replica exchange molecular dynamics (REMD) and the all-atom explicit water model to study binding of Aβ10-40 peptide to the anionic DMPS bilayer. To provide comparison with a zwitterionic bilayer, we used our previous REMD simulations probing binding of the same peptide to the DMPC bilayer. Using two sets of simulations, we comparatively analyzed the equilibrium Aβ conformational ensemble, peptide-bilayer interactions, and changes in the bilayer structure induced by Aβ binding. Our results are six-fold. (1) Binding to the DMPS bilayer triggers the formation of stable helix in the Aβ C-terminal, although the helix-inducing effect caused by DMPS lipids is weaker than that of DMPC. (2) Compared to the DMPC-bound Aβ monomer, the anionic bilayer weakens intrapeptide interactions, particularly, formed by charged amino acids. (3) Binding of Aβ peptide to the DMPS bilayer is primarily governed by electrostatic interactions between charged amino acids and charged lipid groups. In contrast, these interactions play minor role in Aβ binding to the DMPC bilayer. (4) Aβ peptide generally resides on the DMPS bilayer surface causing relatively minor bilayer thinning. The opposite scenario applies to Aβ binding to the DMPC bilayer. (5) In contrast to DMPC simulations, Aβ largely expels anionic lipids from its binding "footprint" forming a ring of charged amino acids mixed with charged lipid groups around the peptide. (6) Aβ binding disorders proximal DMPS lipids more strongly than their DMPC counterparts. Our simulations show that Aβ monomers fail to perturb anionic or zwitterionic bilayers across both leaflets. PMID:26947182

  5. On the stability of foams made with surfactant bilayer phases.

    Science.gov (United States)

    Briceño-Ahumada, Zenaida; Maldonado, Amir; Impéror-Clerc, Marianne; Langevin, Dominique

    2016-02-01

    The stability of foams made with sponge phases (L3 phases) and lamellar phases (L(α) phases), both containing surfactant bilayers, has been investigated. The extreme stability of foams made with lamellar phases seems essentially due to the high viscosity of the foaming solution, which slows down gravity drainage. Moreover, the foams start draining only when the buoyancy stress overcomes the yield stress of the L(α) phase. The bubble growth associated with gas transfer is unusual: it follows a power law with an exponent smaller than those corresponding to Ostwald ripening (wet foams) and to coarsening (dry foams). The foams made with sponge phases are in turn very unstable, even less stable than pure surfactant foams made with glycerol solutions having the same viscosity. The fact that the surfactant bilayers in the sponge phase have a negative Gaussian curvature could facilitate bubble coalescence. PMID:26647140

  6. Quantum Monte Carlo study of bilayer ionic Hubbard model

    Science.gov (United States)

    Jiang, M.; Schulthess, T. C.

    2016-04-01

    The interaction-driven insulator-to-metal transition has been reported in the ionic Hubbard model (IHM) for moderate interaction U , while its metallic phase only occupies a narrow region in the phase diagram. To explore the enlargement of the metallic regime, we extend the ionic Hubbard model to two coupled layers and study the interplay of interlayer hybridization V and two types of intralayer staggered potentials Δ : one with the same (in-phase) and the other with a π -phase shift (antiphase) potential between layers. Our determinant quantum Monte Carlo (DQMC) simulations at lowest accessible temperatures demonstrate that the interaction-driven metallic phase between Mott and band insulators expands in the Δ -V phase diagram of bilayer IHM only for in-phase ionic potentials; while antiphase potential always induces an insulator with charge density order. This implies possible further extension of the ionic Hubbard model from the bilayer case here to a realistic three-dimensional model.

  7. Electrical oscillation in Pt/VO2 bilayer strips

    International Nuclear Information System (INIS)

    We report on the observation of stable electrical oscillation in Pt/vanadium dioxide (VO2) bilayer strips, in which the Pt overlayer serves the dual purposes of heating up the VO2 and weakening the electric field in the VO2 layer. Systematic measurements in an ultrahigh vacuum nanoprobe system show that the oscillation frequency increases with the bias current and/or with decreasing device dimension. In contrast to most VO2-based oscillators reported to date, which are electrically triggered, current-induced Joule heating in the Pt overlayer is found to play a dominant role in the generation of oscillation in Pt/VO2 bilayers. A simple model involving thermally triggered transition of VO2 on a heat sink is able to account for the experimental observations. The results in this work provide an alternative view of the triggering mechanism in VO2-based oscillators

  8. Model for magnetostrictive performance in soft/hard coupled bilayers

    International Nuclear Information System (INIS)

    A model is set up to investigate the magnetostrictive performance and spin response in soft/hard magnetostrictive coupled bilayers. Direct coupling between soft ferromagnet and hard TbFe2 at the interface is assumed. The magnetostriction results from the rotation of ferromagnetic vector and TbFe2 vectors from the easy axis driven by applied magnetic field. Dependence of magnetostriction on TbFe2 layer thickness and interfacial exchange interaction is studied. The simulated results reveal the compromise between interfacial exchange interaction and anisotropy of TbFe2 hard layer. - Highlights: • A model for magnetostrictive performance in soft/hard coupled bilayers. • Simulated magnetostriction loop and corresponding spin response. • Competition and compromise between interfacial interaction and TbFe2 anisotropy. • Dependence of saturated magnetostriction on different parameters

  9. Bilayer thickness mismatch controls domain size in biomimetic membranes

    Science.gov (United States)

    Heberle, Frederick A.; Petruzielo, Robin S.; Pan, Jianjun; Drazba, Paul; Kučerka, Norbert; Standaert, Robert F.; Feigenson, Gerald W.; Katsara, John

    2013-03-01

    In order to promote functionality, cells may alter the spatial organization of membrane lipids and proteins, including separation of liquid phases into distinct domains. In model membranes, domain size and morphology depend strongly on composition and temperature, but the physicochemical mechanisms controlling them are poorly understood. Theoretical work suggests a role for interfacial energy at domain boundaries, which may be driven in part by thickness mismatch between a domain and its surrounding bilayer. However, no direct evidence linking thickness mismatch to domain size in free-standing bilayers has been reported. We describe the use of Small Angle Neutron Scattering (SANS) to detect domains in simplified lipid-only models that mimic the composition of plasma membrane. We find that domain size is controlled by the degree of acyl chain unsaturation of low-melting temperature lipids, and that this size transition is correlated to changes in the thickness mismatch between coexisting liquid phases.

  10. Electron diffraction studies on CVD grown bi-layered graphene

    Science.gov (United States)

    Lingam, Kiran; Karakaya, Mehmet; Podila, Ramakrishna; Quin, Haijun; Rao, Apparao; Dept. of Physics and Astronomy, Clemson University, Clemson, SC USA 29634. Team; Advanced Materials Research Laboratories, Clemson University, Anderson, SC USA 29625 Collaboration

    2013-03-01

    Graphene has generated enormous interest in the scientific community due to its peculiar properties like electron mobility, thermal conductivity etc. Several recent reports on exfoliated graphene emphasized the role of layer stacking on the electronic and optical properties of graphene in case of bi-layered and few layered graphene and several synthesis techniques like chemical vapor deposition (CVD) on Copper foils are employed to prepare graphene for applications at a large scale. However, a correlated study pertinent to the stacking order in CVD grown graphene is still unclear. In this work, using a combination of Raman spectroscopy and selected area electron diffraction analysis we analyzed the preferred misorientation angles in a CVD grown bi-layered graphene and also the role of Cu crystal facets on the graphene stacking order will be presented.

  11. Self-avoiding walks on a bilayer Bethe lattice

    International Nuclear Information System (INIS)

    We propose and study a model of polymer chains in a bilayer. Each chain is confined in one of the layers and polymer bonds on first neighbor edges in different layers interact. We also define and comment on results for a model with interactions between monomers on first neighbor sites of different layers. The thermodynamic properties of the model are studied in the grand-canonical formalism and both layers are considered to be Cayley trees. In the core region of the trees, which we call a bilayer Bethe lattice, we find a very rich phase diagram in the parameter space defined by the two activities of monomers and the Boltzmann factor associated with the interlayer interaction between bonds or monomers. In addition to critical and coexistence surfaces, there are tricritical, bicritical and critical endpoint lines, as well as higher order multicritical points. (paper)

  12. Self-avoiding walks on a bilayer Bethe lattice

    Science.gov (United States)

    Serra, Pablo; Stilck, Jürgen F.

    2014-04-01

    We propose and study a model of polymer chains in a bilayer. Each chain is confined in one of the layers and polymer bonds on first neighbor edges in different layers interact. We also define and comment on results for a model with interactions between monomers on first neighbor sites of different layers. The thermodynamic properties of the model are studied in the grand-canonical formalism and both layers are considered to be Cayley trees. In the core region of the trees, which we call a bilayer Bethe lattice, we find a very rich phase diagram in the parameter space defined by the two activities of monomers and the Boltzmann factor associated with the interlayer interaction between bonds or monomers. In addition to critical and coexistence surfaces, there are tricritical, bicritical and critical endpoint lines, as well as higher order multicritical points.

  13. Phase-separation transitions in asymmetric lipid bilayers

    CERN Document Server

    Shimobayashi, Shunsuke F; Taniguchi, Takashi

    2015-01-01

    Morphological transitions of phase separation associated with the asymmetry of lipid composition were investigated using micrometer-sized vesicles of lipid bilayers made from a lipid mixture. The complete macro-phase-separated morphology undergoes a transition to a micro-phase-separation-like morphology via a lorate morphology as a metastable state. The transition leads to the emergence of monodisperse nanosized domains through repeated domain scission events. Moreover, we have numerically confirmed the transitions using the time-dependent Ginzburg-Landau model describing phase separation and the bending elastic membrane, which is quantitatively consistent with experimental results by fixing one free parameter. Our findings suggest that the local spontaneous curvature due to the asymmetric composition plays an essential role in the thermodynamic stabilization of micro-phase separation in lipid bilayers.

  14. Effect of PEGylation on Drug Entry into Lipid Bilayer

    DEFF Research Database (Denmark)

    Rissanen, S.; Kumorek, M.; Martinez-Seara, H.;

    2014-01-01

    dynamics (MD) simulations to consider the behavior of two drug molecules functionalized with PEG (tetraphenylporphyrin used in cancer phototherapy and biochanin A belonging to the isoflavone family) in the presence of a lipid bilayer. The commonly held view is that functionalization of a drug molecule with......Poly(ethylene glycol) (PEG) is a polymer commonly used for functionalization of drug molecules to increase their bloodstream lifetime, hence efficacy. However, the interactions between the PEGylated drugs and biomembranes are not clearly understood. In this study, we employed atomic-scale molecular...... a polymer acts as an entropic barrier, inhibiting the penetration of the drug molecule through a cell membrane. Our results indicate that in the bloodstream there is an additional source of electrostatic repulsive interactions between the PEGylated drugs and the lipid bilayer. Both the PEG chain and...

  15. Physisorbed Polymer-Tethered Lipid Bilayer with Lipopolymer Gradient

    Directory of Open Access Journals (Sweden)

    Christoph A. Naumann

    2012-11-01

    Full Text Available Physisorbed polymer-tethered lipid bilayers consisting of phospholipids and lipopolymers represent an attractive planar model membrane platform, in which bilayer fluidity and membrane elastic properties can be regulated through lipopolymer molar concentration. Herein we report a method for the fabrication of such a planar model membrane system with a lateral gradient of lipopolymer density. In addition, a procedure is described, which leads to a sharp boundary between regions of low and high lipopolymer molar concentrations. Resulting gradients and sharp boundaries are visualized on the basis of membrane buckling structures at elevated lipopolymer concentrations using epifluorescence microscopy and atomic force microscopy. Furthermore, results from spot photobleaching experiments are presented, which provide insight into the lipid lateral fluidity in these model membrane architectures. The presented experimental data highlight a planar, solid-supported membrane characterized by fascinating length scale-dependent dynamics and elastic properties with remarkable parallels to those observed in cellular membranes.

  16. Bilayer graphene: physics and application outlook in photonics

    Directory of Open Access Journals (Sweden)

    Yan Hugen

    2015-05-01

    Full Text Available Layered materials, such as graphene, transition metal dichacogenides and black phosphorus have attracted lots of attention recently. They are emerging novel materials in electronics and photonics, with tremendous potential in revolutionizing the traditional electronics and photonics industry. Marrying layered material to the nanophotonics is being proved fruitful. With the recent emphasis and development of metasurfaces in nanophotonics, atomically thin materials can find their unique position and strength in this field. In this article, I will focus on one specific two dimensional material: bilayer graphene. Basic physics will be reviewed, such as band-gap opening, electron-phonon interaction, phonon-plasmon interaction and Fano resonances in the optical response. Moreover, I will review the application of bilayer graphene as a sensitive and fast photodetector. An outlook will be given in the final part of the paper.

  17. Wrinkled bilayer graphene with wafer scale mechanical strain

    Science.gov (United States)

    Mikael, Solomon; Seo, Jung-Hun; Javadi, Alireza; Gong, Shaoqin; Ma, Zhenqiang

    2016-05-01

    Wafer-scale strained bilayer graphene is demonstrated by employing a silicon nitride (Si3N4) stressor layer. Different magnitudes of compressive stress up to 840 MPa were engineered by adjusting the Si3N4 deposition recipes, and different strain conditions were analyzed using Raman spectroscopy. The strained graphene displayed significant G peak shifts and G peak splitting with 16.2 cm-1 and 23.0 cm-1 of the G band and two-dimensional band shift, which corresponds to 0.26% of strain. Raman mapping of large regions of the graphene films found that the largest shifts/splitting occurred near the bilayer regions of the graphene films. The significance of our approach lies in the fact that it can be performed in a conventional microfabrication process, i.e., the plasma enhanced chemical vapor deposition system, and thus easily implemented for large scale production.

  18. Methodological problems in pressure profile calculations for lipid bilayers

    DEFF Research Database (Denmark)

    Sonne, Jacob; Hansen, Flemming Yssing; Peters, Günther H.J.

    2005-01-01

    calculations: The first problem is that the pressure profile is not uniquely defined since the expression for the local pressure involves an arbitrary choice of an integration contour. We have investigated two different choices leading to the Irving-Kirkwood (IK) and Harasima (H) expressions for the local......From molecular dynamics simulations of a dipalmitoyl-phosphatidyl-choline (DPPC) lipid bilayer in the liquid crystalline phase, pressure profiles through the bilayer are calculated by different methods. These profiles allow us to address two central and unresolved problems in pressure profile...... and H profiles are calculated in order to test the uniqueness of the profile. The second problem is how to include electrostatic interactions in pressure profile calculations when the simulations are conducted without truncating the electrostatic potential, i.e., using the Ewald summation technique...

  19. Model for magnetostrictive performance in soft/hard coupled bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Jianjun, Li, E-mail: ljj8081@gmail.com [National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150080 (China); Laboratoire de Magnétisme de Bretagne, Université de Bretagne Occidentale, 29238 Brest Cedex 3 (France); Beibei, Duan; Minglun, Li [National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150080 (China)

    2015-11-01

    A model is set up to investigate the magnetostrictive performance and spin response in soft/hard magnetostrictive coupled bilayers. Direct coupling between soft ferromagnet and hard TbFe{sub 2} at the interface is assumed. The magnetostriction results from the rotation of ferromagnetic vector and TbFe{sub 2} vectors from the easy axis driven by applied magnetic field. Dependence of magnetostriction on TbFe{sub 2} layer thickness and interfacial exchange interaction is studied. The simulated results reveal the compromise between interfacial exchange interaction and anisotropy of TbFe{sub 2} hard layer. - Highlights: • A model for magnetostrictive performance in soft/hard coupled bilayers. • Simulated magnetostriction loop and corresponding spin response. • Competition and compromise between interfacial interaction and TbFe{sub 2} anisotropy. • Dependence of saturated magnetostriction on different parameters.

  20. Anomalous Hall effect in YIG|Pt bilayers

    International Nuclear Information System (INIS)

    We measure the ordinary and the anomalous Hall effect in a set of yttrium iron garnet|platinum (YIG|Pt) bilayers via magnetization orientation dependent magnetoresistance experiments. Our data show that the presence of the ferrimagnetic insulator YIG leads to an anomalous Hall effect like voltage in Pt, which is sensitive to both Pt thickness and temperature. Interpretation of the experimental findings in terms of the spin Hall anomalous Hall effect indicates that the imaginary part of the spin mixing conductance Gi plays a crucial role in YIG|Pt bilayers. In particular, our data suggest a sign change in Gi between 10 K and 300 K. Additionally, we report a higher order Hall effect contribution, which appears in thin Pt films on YIG at low temperatures

  1. Anomalous Hall effect in YIG|Pt bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Sibylle, E-mail: sibylle.meyer@wmi.badw.de; Schlitz, Richard [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, 85748 Garching (Germany); Physik-Department, Technische Universität München, 85748 Garching (Germany); Geprägs, Stephan; Opel, Matthias [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, 85748 Garching (Germany); Huebl, Hans; Goennenwein, Sebastian T. B. [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, 85748 Garching (Germany); Nanosystems Initiative Munich, 80799 München (Germany); Gross, Rudolf [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, 85748 Garching (Germany); Physik-Department, Technische Universität München, 85748 Garching (Germany); Nanosystems Initiative Munich, 80799 München (Germany)

    2015-03-30

    We measure the ordinary and the anomalous Hall effect in a set of yttrium iron garnet|platinum (YIG|Pt) bilayers via magnetization orientation dependent magnetoresistance experiments. Our data show that the presence of the ferrimagnetic insulator YIG leads to an anomalous Hall effect like voltage in Pt, which is sensitive to both Pt thickness and temperature. Interpretation of the experimental findings in terms of the spin Hall anomalous Hall effect indicates that the imaginary part of the spin mixing conductance G{sub i} plays a crucial role in YIG|Pt bilayers. In particular, our data suggest a sign change in G{sub i} between 10 K and 300 K. Additionally, we report a higher order Hall effect contribution, which appears in thin Pt films on YIG at low temperatures.

  2. Spin rectification by orbital polarization in Bi-bilayer nanoribbons.

    Science.gov (United States)

    Jin, Kyung-Hwan; Jhi, Seung-Hoon

    2016-03-16

    We investigate the edge states of quantum spin-Hall phase Bi(111) bilayer nano-ribbons (BNRs) and their spin-rectifying effect using first-principles calculations and a non-equilibrium transport method. As low-dimensional materials, BNRs have tunable electronic properties, which are not only dependent on the edge shape, chemical passivation, or external electric fields but also governed by geometrical deformation. Depending on the passivation types, the interaction of the helical edge states in BNRs exhibits various patterns, enabling the valley engineering of the Dirac cones. In addition, the spin texture of the Dirac state is significantly tuned by edge passivation, external electric fields and geometric deformations. We demonstrate that curved BNRs can be used as the spin valves to rectify the electric currents via the edge states. Our results provide a practical way of utilizing two-dimensional topological insulator Bi bilayers for spintronic devices. PMID:26947010

  3. Asymmetric bilayer graphene nanoribbon MOSFETs for analog and digital electronics

    Science.gov (United States)

    Dinarvand, A.; Ahmadi, V.; Darvish, Gh.

    2016-05-01

    In this paper, a new structure was proposed for bilayer graphene nanoribbon field-effect transistor (BGNFET) mainly to enhance the electrical characteristics in analog and digital applications. The proposed device uses two metallic gates on the top and bottom of a bilayer graphene nanoribbon, which is surrounded by SiO2 and connected to heavily doped source/drain contacts. Electrical properties of the proposed device were explored using fully self-consistent solution of Poisson and Schrödinger equations based on the nonequilibrium Green's function (NEGF) formalism. Significant improvements in the electrical behavior was seen in the simulation results for gates asymmetrically biased. The comparison with graphene nanoribbon FET showed that the proposed structure benefited from higher intrinsic voltage gain and cut-off frequency and improved switching characteristics such as delay and Ion/Ioff ratio.

  4. Optical response of Al/Ti bilayer transition edge sensors

    Science.gov (United States)

    Zhang, Qing-Ya; Wang, Tian-Shun; Liu, Jian-She; Dong, Wen-Hui; He, Gen-Fang; Li, Tie-Fu; Zhou, Xing-Xiang; Chen, Wei

    2014-11-01

    We report the optical response characteristics of Al/Ti bilayer transition edge sensors (TESs), which are mainly comprised of Al/Ti bilayer thermometers and suspended SiN membranes for thermal isolation. The measurement was performed in a 3He sorption refrigerator and the device's response to optical pulses was investigated using a pulsed laser source. Based on these measurements, we obtained the effective recovery time (τeff) of the devices at different biases and discussed the dependence of τeff on the bias. The device with a 940 μm × 940 μm continuous suspended SiN membrane demonstrated a fast response speed with τeff = 3.9 μs, which indicates a high temperature sensitivity (α = T/R · dR/dT = 326). The results also showed that the TES exhibits good linearity under optical pulses of variable widths.

  5. Exchange bias in diluted-antiferromagnet/antiferromagnet bilayers

    International Nuclear Information System (INIS)

    The hysteresis-loop properties of a diluted-antiferromagnetic (DAF) layer exchange coupling to an antiferromagnetic (AF) layer are investigated by means of numerical simulations. Remarkable loop shift and coercivity enhancement are observed in such DAF/AF bilayers, while they are absent in the uncoupled DAF single layer. The influences of pinned domains, dilution, cooling field and DAF layer thickness on the loop shift are investigated systematically. The result unambiguously confirms an exchange bias (EB) effect in the DAF/AF bilayers. It also reveals that the EB effect originates from the pinned AF domains within the DAF layer. In contrast to conventional EB systems, frozen uncompensated spins are not found at the interface of the AF pinning layer. (paper)

  6. Hybrid bilayer plasmonic metasurface efficiently manipulates visible light

    OpenAIRE

    Qin, Fei; Ding, Lu; Zhang, Lei; Monticone, Francesco; Chum, Chan Choy; Deng, Jie.; Mei, Shengtao; Ying LI; Teng, Jinghua; Hong, Minghui; Shuang ZHANG; Alù, Andrea; Qiu, Cheng-Wei

    2016-01-01

    Metasurfaces operating in the cross-polarization scheme have shown an interesting degree of control over the wavefront of transmitted light. Nevertheless, their inherently low efficiency in visible light raises certain concerns for practical applications. Without sacrificing the ultrathin flat design, we propose a bilayer plasmonic metasurface operating at visible frequencies, obtained by coupling a nanoantenna-based metasurface with its complementary Babinet-inverted copy. By breaking the ra...

  7. Quantum quench dynamics and population inversion in bilayer graphene

    OpenAIRE

    Dóra, Balázs; Castro, Eduardo V.; Moessner, Roderich

    2010-01-01

    The gap in bilayer graphene (BLG) can directly be controlled by a perpendicular electric field. By tuning the field through zero at a finite rate in neutral BLG, excited states are produced. Due to screening, the resulting dynamics is determined by coupled non-linear Landau-Zener models. The generated defect density agrees with Kibble-Zurek theory in the presence of subleading logarithmic corrections. After the quench, population inversion occurs for wavevectors close to the Dirac point. This...

  8. Molecular dynamics simulation of melittin in a dimyristoylphosphatidylcholine bilayer membrane.

    OpenAIRE

    Bernèche, S; Nina, M; Roux, B

    1998-01-01

    Molecular dynamics trajectories of melittin in an explicit dimyristoyl phosphatidylcholine (DMPC) bilayer are generated to study the details of lipid-protein interactions at the microscopic level. Melittin, a small amphipathic peptide found in bee venom, is known to have a pronounced effect on the lysis of membranes. The peptide is initially set parallel to the membrane-solution interfacial region in an alpha-helical conformation with unprotonated N-terminus. Solid-state nuclear magnetic reso...

  9. The Stability and Charge Carriers in Bilayer Silicene

    OpenAIRE

    Rui, Wang; Shaofeng, Wang; Xiaozhi, Wu

    2013-01-01

    The structure optimization, phonon, and ab initio ?nite temperature molecular dynamics calculations have been performed to predict that bilayer silicene has stable structure with AB stacking geometry and is more favorable energetically to synthesize than monolayer silicene, a two-dimensional honeycomb lattice with buckled geometry. Marvellously, its electronic bands show that the charge carriers behave like relativistic Dirac fermions with linear energy dispersions near the K points. An insig...

  10. Robustly Engineering Thermal Conductivity of Bilayer Graphene by Interlayer Bonding

    OpenAIRE

    Xiaoliang Zhang; Yufei Gao; Yuli Chen; Ming Hu

    2016-01-01

    Graphene and its bilayer structure are the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. Their realistic applications in emerging nanoelectronics usually call for thermal transport manipulation in a controllable and precise manner. In this paper we systematically studied the effect of interlayer covalent bonding, in particular different interlay bonding arrangement, on the...

  11. Exchange bias in Fe/KNiF3 bilayers

    Science.gov (United States)

    Wee, L.; Stamps, R. L.; Celinski, Z.; Skrzypek, D.

    2001-06-01

    The exchange bias effect is known to depend strongly on the condition of the ferromagnet/antiferromagnet interface. Bilayers of single-crystal Fe and polycrystalline KNiF3 were grown and exchange bias observed using superconducting quantum interference device magnetometry. Hysteresis loops after field cooling are asymmetric in the forward and reverse directions. This asymmetry disappears at 50 K, indicating a blocking temperature for the bias well below the Néel temperature of KNiF3 (250 K).

  12. Effect of monoglycerides and fatty acids on a ceramide bilayer

    OpenAIRE

    Akinshina, Anna; Das, Chinmay; Noro, Massimo G.

    2016-01-01

    Monoglycerides and unsaturated fatty acids, naturally present in trace amounts in the stratum corneum (top layer of skin) lipid matrix, are commonly used in pharmaceutical, cosmetic and health care formulations. However, a detailed molecular understanding of how the oil additives get incorporated into the skin lipids from topical application and, once incorporated, how they affect the properties and integrity of the lipid matrix remains unexplored. Using ceramide 2 bilayers as skin lipid surr...

  13. Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen

    OpenAIRE

    Perioli, Luana; Ambrogi, Valeria; Giovagnoli, Stefano; Ricci, Maurizio; Blasi, Paolo; Rossi, Carlo

    2007-01-01

    The aim of this work was the design of sustained-release mucoadhesive bilayered tablets, using mixtures of mucoadhesive polymers and an inorganic matrix (hydrotalcite), for the topical administration of flurbiprofen in the oral cavity. The first layer, responsible for the tablet retention on the mucosa, was prepared by compression of a cellulose derivative and polyacrylic derivative blend. The second layer, responsible for buccal drug delivery, was obtained by compression of a mixture of the ...

  14. Comparison of thermal fluctuations in foam films and bilayer structures

    OpenAIRE

    Ivanova, N. G.; Tsekov, R.

    2013-01-01

    In the frames of the DLVO theory the root mean square amplitude and correlation length of capillary waves in thin liquid films are calculated. Their dependencies on some important physical parameters are studied. Two models are considered: films with classical interfaces and films between lipid bilayers. The performed numerical analysis demonstrates essential difference in their behavior, which is due to the different elastic properties of the film surfaces in the models.

  15. Helix insertion into bilayers and the evolution of membrane proteins

    OpenAIRE

    Renthal, Robert

    2009-01-01

    Polytopic α-helical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic α-helical membrane proteins that already reside in the membrane. This raises the question of how these proteins evolved. Our current knowledge of the insertion of α-helices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membrane proteins. Topics include: translocon-dependent membrane protein insertion, antibiotic peptides ...

  16. Lipid Bilayer Formation in Aqueous Solutions of Ionic Liquids

    OpenAIRE

    Young, Taylor Tront

    2012-01-01

    The formation of lipid bilayer membranes between droplets of ionic liquid is presented as a means of forming functional bimolecular networks for use in sensor applications. Ionic liquids are salts that have a number of useful properties, such as low melting points making them liquid at room temperature and exceedingly low vapor pressure. Ionic liquids have seen recent popularity as environmentally friendly industrial solvent alternatives. Our research demonstrates that it is possible to cons...

  17. Electronic spin transport in bilayer and single layer graphene

    OpenAIRE

    Yang, Tsung-Yeh

    2011-01-01

    Graphene has drawn plenty of attention since its discovery in 2004. Due to its excellent properties, such as long spin relaxation length and gate-tunable spin transport, graphene is expected to be a potential candidate for spintronics applications. In this thesis, the systematic study of the spin relaxation mechanisms in bilayer and single layer graphene is presented. Graphene-based spin valve devices in four-terminal non-local geometry are fabricated for the investigation of the charge and s...

  18. Interactions of monovalent salts with cationic lipid bilayers

    Czech Academy of Sciences Publication Activity Database

    Pokorná, Šárka; Jurkiewicz, Piotr; Cwiklik, Lukasz; Vazdar, Mario; Hof, Martin

    2013-01-01

    Roč. 160, č. 2013 (2013), s. 341-358. ISSN 1359-6640 R&D Projects: GA ČR GBP208/12/G016; GA AV ČR GEMEM/09/E006 Institutional support: RVO:61388955 ; RVO:61388963 Keywords : FLUORESCENCE SOLVENT RELAXATION * MOLECULAR-DYNAMICS SIMULATIONS * PHOSPHOLIPID-BILAYERS Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.194, year: 2013

  19. Formation of artificial lipid bilayers using droplet dielectrophoresis

    OpenAIRE

    Aghdaei, Sara; Sandison, Mairi E.; Zagnoni, Michele; Green, Nicolas G; Morgan, Hywel

    2008-01-01

    We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid-alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be...

  20. A defect mediated lamellar to isotropic transition of amphiphile bilayers

    OpenAIRE

    Pal, Antara; Pabst, Georg; Raghunathan, V. A.

    2011-01-01

    We report the observation of a novel isotropic phase of amphiphile bilayers in a mixed system consisting of the ionic surfactant, sodium docecylsulphate (SDS), and the organic salt p-toludine hydrochloride (PTHC). This system forms a collapsed lamellar ($L_\\alpha$) phase over a wide range of water content, which transforms into an isotropic phase on heating. This transition is not observed in samples without excess water, where the $L_\\alpha$ phase is stable at higher temperatures. Our observ...

  1. The lipid bilayer membrane and its interactions with additives.

    OpenAIRE

    Meijer, L.A.

    1994-01-01

    The aim of this study was to make accurate predictions on the interaction of biologically relevant molecules with lipid bilayer membranes. We emphasised on the partitioning of these molecules between the membrane phase, and the aqueous phase quantified by the partition coefficient. To make detailed predictions a theory had to be set up along the lines of the self-consistent-field theory developed by Scheutjens and Fleer and extended by Evers, Leermakers, Van Lent, Böhmer, Barneveld, Israëls, ...

  2. Capacitance of Graphene Bilayer as a Which-Layer Probe

    OpenAIRE

    Young, Andrea F.; Levitov, Leonid S.

    2011-01-01

    The unique capabilities of capacitance measurements in bilayer graphene enable probing of layer-specific properties that are normally out of reach in transport measurements. Furthermore, capacitance measurements in the top-gate and penetration field geometries are sensitive to different physical quantities: the penetration field capacitance probes the two layers equally, whereas the top gate capacitance preferentially samples the near layer, resulting in the "near-layer capacitance enhancemen...

  3. Predicting proton titration in cationic micelle and bilayer environments

    OpenAIRE

    Brian H. Morrow; Eike, David M.; Murch, Bruce P.; Koenig, Peter H.; Shen, Jana K.

    2014-01-01

    Knowledge of the protonation behavior of pH-sensitive molecules in micelles and bilayers has significant implications in consumer product development and biomedical applications. However, the calculation of pKa’s in such environments proves challenging using traditional structure-based calculations. Here we apply all-atom constant pH molecular dynamics with explicit ions and titratable water to calculate the pKa of a fatty acid molecule in a micelle of dodecyl trimethylammonium chloride and l...

  4. Tight-binding study of bilayer graphene Josephson junctions

    OpenAIRE

    Muñoz, W. A.; Covaci, L.; Peeters, F. M.

    2012-01-01

    Using highly efficient simulations of the tight-binding Bogoliubov-de Gennes model we solved self-consistently for the pair correlation and the Josephson current in a Superconducting-Bilayer graphene-Superconducting Josephson junction. Different doping levels for the non-superconducting link are considered in the short and long junction regime. Self-consistent results for the pair correlation and superconducting current resemble those reported previously for single layer graphene except in th...

  5. Enhanced Thermoelectric Power in Dual-Gated Bilayer Graphene

    OpenAIRE

    Wang, Chang-Ran; Lu, Wen-Sen; Hao, Lei; Lee, Wei-Li; Lee, Ting-Kuo; Lin, Feng; Cheng, I-Chun; Chen, Jian-Zhang

    2011-01-01

    Thermoelectric power of a material, typically governed by its band structure and carrier density, can be varied by chemical doping that is often restricted by solubility of the dopant. Materials showing large thermoelectric power are useful for many industrial applications, such as the heat-to-electricity conversion and the thermoelectric cooling device. Here we show a full electric field tuning of thermoelectric power in a dual-gated bilayer graphene device resulting from the opening of a ba...

  6. Cooperative Multiscale Aging in a Ferromagnet/Antiferromagnet Bilayer

    OpenAIRE

    Urazhdin, Sergei

    2015-01-01

    We utilize anisotropic magnetoresistance to study temporal evolution of the magnetization state in epitaxial Ni$_{80}$Fe$_{20}$/Fe$_{50}$Mn$_{50}$ ferromagnet/antiferromagnet bilayers. The resistance exhibits power-law evolution over a wide range of temperatures and magnetic fields, indicating that aging is characterized by a wide range of activation time scales. We show that aging is a cooperative process, i.e. the magnetic system is not a superposition of weakly interacting subsystems chara...

  7. Elastic deformation and failure of lipid bilayer membranes containing cholesterol.

    OpenAIRE

    Needham, D; Nunn, R. S.

    1990-01-01

    Giant bilayer vesicles were reconstituted from several lipids and lipid/cholesterol (CHOL) mixtures: stearolyloleoylphosphatidylcholine (SOPC), bovine sphingomyelin (BSM), diarachidonylphosphatidylcholine (DAPC), SOPC/CHOL, BSM/CHOL, DAPC/CHOL, and extracted red blood cell (RBC) lipids with native cholesterol. Single-walled vesicles were manipulated by micropipette suction and several membrane material properties were determined. The properties measured were the elastic area compressibility m...

  8. Anomalous Hall effect in YIG$|$Pt bilayers

    OpenAIRE

    Meyer, Sibylle; Schlitz, Richard; Geprägs, Stephan; Opel, Matthias; Huebl, Hans; Gross, Rudolf; Goennenwein, Sebastian T. B.

    2015-01-01

    We measure the ordinary and the anomalous Hall effect in a set of yttrium iron garnet$|$platinum (YIG$|$Pt) bilayers via magnetization orientation dependent magnetoresistance experiments. Our data show that the presence of the ferrimagnetic insulator YIG leads to an anomalous Hall like signature in Pt, sensitive to both Pt thickness and temperature. Interpretation of the experimental findings in terms of the spin Hall anomalous Hall effect indicates that the imaginary part of the spin mixing ...

  9. Atomic force microscopic study on lipid bilayer nanoscale phase separation

    OpenAIRE

    Liu, Rui

    2014-01-01

    Phase separation of copolymers or lipid membranes in nanoscale has attracted increasing interests for their applications in the synthesis of inorganic nanomaterial. The nanoscale phase separation of liquid bilayer as a supported membrane is systematically investigated by atomic force microscope (AFM). Moreover, the position of the fluorescence indicator, which is commonly used in the phase separation study in optical microscope, is also probed in this study to complete the knowledge of tradit...

  10. Phase-separation transitions in asymmetric lipid bilayers

    OpenAIRE

    Shimobayashi, Shunsuke F.; Ichikawa, Masatoshi; Taniguchi, Takashi

    2015-01-01

    Morphological transitions of phase separation associated with the asymmetry of lipid composition were investigated using micrometer-sized vesicles of lipid bilayers made from a lipid mixture. The complete macro-phase-separated morphology undergoes a transition to a micro-phase-separation-like morphology via a lorate morphology as a metastable state. The transition leads to the emergence of monodisperse nanosized domains through repeated domain scission events. Moreover, we have numerically co...

  11. Quantum Hall effect in bilayer system with array of antidots

    Science.gov (United States)

    Pagnossin, I. R.; Gusev, G. M.; Sotomayor, N. M.; Seabra, A. C.; Quivy, A. A.; Lamas, T. E.; Portal, J. C.

    2007-04-01

    We have studied the Quantum Hall effect in a bilayer system modulated by gate-controlled antidot lattice potential. The Hall resistance shows plateaus which are quantized to anomalous multiplies of h/e2. We suggest that this complex behavior is due to the nature of the edge-states in double quantum well (DQW) structures coupled to an array of antidots: these plateaus may be originated from the coexistence of normal and counter-rotating edge-states in different layers.

  12. Theory of integer quantum Hall effect in insulating bilayer graphene

    OpenAIRE

    Roy, Bitan

    2012-01-01

    A variational ground state for insulating bilayer graphene (BLG), subject to quantizing magnetic fields, is proposed. Due to the Zeeman coupling, the layer anti-ferromagnet (LAF) order parameter in fully gapped BLG gets projected onto the spin easy plane, and simultaneously a ferromagnet order, which can further be enhanced by exchange interaction, develops in the direction of the magnetic field. The activation gap for the $\

  13. Supported lipid bilayer membranes for water purification by reverse osmosis.

    Science.gov (United States)

    Kaufman, Yair; Berman, Amir; Freger, Viatcheslav

    2010-05-18

    Some biological plasma membranes pass water with a permeability and selectivity largely exceeding those of commercial membranes for water desalination using specialized trans-membrane proteins aquaporins. However, highly selective transport of water through aquaporins is usually driven by an osmotic rather mechanical pressure, which is not as attractive from the engineering point of view. The feasibility of adopting biomimetic membranes for water purification driven by a mechanical pressure, i.e., filtration is explored in this paper. Toward this goal, it is proposed to use a commercial nanofiltration (NF) membrane as a support for biomimetic lipid bilayer membranes to render them robust enough to withstand the required pressures. It is shown in this paper for the first time that by properly tuning molecular interactions supported phospholipid bilayers (SPB) can be prepared on a commercial NF membrane. The presence of SPB on the surface was verified and quantified by several spectroscopic and microscopic techniques, which showed morphology close to the desired one with very few defects. As an ultimate test it is shown that hydraulic permeability of the SPB supported on the NF membrane (NTR-7450) approaches the values deduced from the typical osmotic permeabilities of intact continuous bilayers. This permeability was unaffected by the trans-membrane flow of water and by repeatedly releasing and reapplying a 10 bar pressure. Along with a parallel demonstration that aquaporins could be incorporated in a similar bilayer on mica, this demonstrates the feasibility of the proposed approach. The prepared SPB structure may be used as a platform for preparing biomimetic filtration membranes with superior performance based on aquaporins. The concept of SPBs on permeable substrates of the present type may also be useful in the future for studying transport of various molecules through trans-membrane proteins. PMID:20099798

  14. Persistent Currents and Dissipation in Narrow Bilayer Quantum Hall Bars

    OpenAIRE

    Kyriakidis, Jordan; Radzihovsky, Leo

    2000-01-01

    Bilayer quantum Hall states support a flow of nearly dissipationless staggered current which can only decay through collective channels. We study the dominant finite-temperature dissipation mechanism which in narrow bars is driven by thermal nucleation of pseudospin solitons. We find the finite-temperature resistivity, predict the resulting staggered current-voltage characteristics, and calculate the associated zero-temperature critical staggered current and gate voltage.

  15. Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles

    OpenAIRE

    Liu, Juewen; Stace-Naughton, Alison; Jiang, Xingmao; Brinker, C. Jeffrey

    2009-01-01

    Mixing liposomes with hydrophilic particles will induce fusion of the liposome onto the particle surface. Such supported bilayers have been extensively studied as a model for the cell membrane, while its application in drug delivery has not been pursued. In this communication, we report the use of phospholipids to achieve synergistic loading and encapsulating of a fluorescent dye (calcein) in mesoporous silica nanoparticles, and its delivery into mammalian cells. We found that cationic lipid ...

  16. Self-assembling bilayers of palladiumthiolates in organic media

    Indian Academy of Sciences (India)

    P John Thomas; A Lavanya; V Sabareesh; G U Kulkarni

    2001-10-01

    Alkylthiolates of palladium forming a homologous series (butyl to octadecyl) have been prepared and characterized using X-ray diffraction and STM. The thiolates adopt an unusual bilayered lamellar structure, whose thickness is governed by the length of the alkyl chain. These mesophases melt in the temperature range, 60° to 100°C, with the melting point increasing linearly with the thiol chain length. There is evidence to suggest that the alkyl chains are orientationally disordered especially prior to melting.

  17. Entanglement spectrum of fermionic bilayer honeycomb lattice: Hofstadter butterfly

    OpenAIRE

    Moradi, Z; Abouie, J.

    2016-01-01

    We perform an analytical study of the energy and entanglement spectrum of non-interacting fermionic bilayer honeycomb lattices in the presence of trigonal warping in the energy spectrum, on-site energy difference and uniform magnetic field. Employing single particle correlation functions, we present an explicit form for layer-layer entanglement Hamiltonian whose spectrum is entanglement spectrum. We demonstrate that in the absence of trigonal warping, at zero on-site energy difference exact c...

  18. Intermolecular interactions of lysobisphosphatidic acid with phosphatidylcholine in mixed bilayers.

    Science.gov (United States)

    Holopainen, Juha M; Söderlund, Tim; Alakoskela, Juha-Matti; Säily, Matti; Eriksson, Ove; Kinnunen, Paavo K J

    2005-01-01

    Lysobisphosphatidic acid (LBPA) can be regarded to represent a unique derivative of phosphatidylglycerol. This lipid is highly enriched in late endosomes where it can comprise up to 10-15 mol% of all lipids and in these membranes, LBPA appears to be segregated into microdomains. We studied the thermotropic behavior of pure dioleoyl-LBPA mono- and bilayers using Langmuir-lipid monolayers, electron microscopy, differential scanning calorimetry (DSC), and fluorescence spectroscopy. LBPA formed metastable, liquid-expanded monolayers at an air/buffer interface, and its compression isotherms lacked any indication for structural phase transitions. Neat LBPA formed multilamellar vesicles with no structural transitions or phase transitions between 10 and 80 degrees C at a pH range of 3.0-7.4. We then proceeded to study mixed LBPA/dipalmitoylphosphatidylcholine (DPPC) bilayers by DSC and fluorescence spectroscopy. Incorporating increasing amounts of LBPA (up to X(LBPA) (molar fraction)=0.10) decreased the co-operativity of the main transition for DPPC, and a decrease in the main phase transition as well as pretransition temperature of DPPC was observed yet with no effect on the enthalpy of this transition. In keeping with the DSC data for DPPC, 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC)/LBPA mixed bilayers were more fluid, and no evidence for lateral phase segregation was observed. These results were confirmed using fluorescence microscopy of Langmuir-lipid films composed of POPC and LBPA up to X(LBPA)=0.50 with no evidence for lateral phase separation. As late endosomes are eminently acidic, we examined the effect of lowering pH on lateral organization of mixed PC/LBPA bilayers by DSC and fluorescence spectroscopy. Even at pH 3.0, we find no evidence of LBPA-induced microdomain formation at LBPA contents found in cellular organelles. PMID:15589226

  19. Pedot and PPy Conducting Polymer Bilayer and Trilayer Actuators

    DEFF Research Database (Denmark)

    Zainudeen, Umer Lebbe; Careem, Mohamed Abdul; Skaarup, Steen

    2008-01-01

    Actuators based on conducting polymers are attracting increasing interest due to their desirable features such as large mechanical stress generated, sufficient maximum strain values, high reversibility, good safety properties and the possibility of precise control using small voltages. Many...... attempts have been made to improve the actuator performance. We report electromechanical measurements on actuators of bilayer and trilayer free standing films prepared with polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) conducting polymers. Both types of conducting polymer are pre...

  20. Unassisted translocation of large polypeptide domains across phospholipid bilayers

    OpenAIRE

    Brambillasca, Silvia; Yabal, Monica; Makarow, Marja; Borgese, Nica

    2006-01-01

    Although transmembrane proteins generally require membrane-embedded machinery for integration, a few can insert spontaneously into liposomes. Previously, we established that the tail-anchored (TA) protein cytochrome b(5) (b5) can posttranslationally translocate 28 residues downstream to its transmembrane domain (TMD) across protein-free bilayers (Brambillasca, S., M. Yabal, P. Soffientini, S. Stefanovic, M. Makarow, R.S. Hegde, and N. Borgese. 2005. EMBO J. 24:2533–2542). In the present study...

  1. 90° Rotation of orbital stripes in bilayer manganite PrCa{sub 2}Mn{sub 2}O{sub 7} studied by in situ transmission electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    He, Z.B., E-mail: Zhanbing.He@ua.ac.be [Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, Antwerp B-2020 (Belgium); Deng, G. [Laboratory for Developments and Methods, Paul Scherrer Institute, Villigen CH-5232 (Switzerland); Bragg Institute, Australian Nuclear Science and Technology Organization, New Illawarra Road, Lucas Heights, NSW 2234 (Australia); Tian, H. [Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, Antwerp B-2020 (Belgium); Xu, Q. [Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, Antwerp B-2020 (Belgium); National Centre for High Resolution Electron Microscopy, Technical University Delft, Lorentzweg 1, CJ Delft 2628 (Netherlands); Van Tendeloo, G. [Electron Microscopy for Materials Research (EMAT), University of Antwerp, Groenenborgerlaan 171, Antwerp B-2020 (Belgium)

    2013-04-15

    We present an in situ transmission electron microscopy study on the half-doped bilayer manganite PrCa{sub 2}Mn{sub 2}O{sub 7} to reveal the rotation process of the orbital stripes. Between the reported initial and final ordering phases, we identified an intermediate state with two sets of satellite spots to bridge the 90° rotation of the orbital stripes. Furthermore, we determined that the rotation of the orbital stripes does not always occur. Some restricted conditions for the orbital rotation to occur were found and reasons are discussed. - Graphical abstract: The intermediate state of the thermally induced 90° rotation of orbital stripes between two charge/orbital ordering CO1 and CO2 phase in the bilayer manganite PrCa{sub 2}Mn{sub 2}O{sub 7} is revealed by in situ TEM. A new state with two sets of satellite spots in the [001] electron diffraction patterns is found to bridge this transition. The reasons to this transition are explained. Highlights: ► Intermediate states to bridge the 90° rotation of the orbital stripes in bilayer manganite PrCa{sub 2}Mn{sub 2}O{sub 7} were identified. ► Some restricted conditions for the orbital rotation to occur were found and reasons were discussed. ► The reported CO2 phase at high temperatures in PrCa{sub 2}Mn{sub 2}O{sub 7} can also exist at room temperature.

  2. Hybrid bilayer plasmonic metasurface efficiently manipulates visible light.

    Science.gov (United States)

    Qin, Fei; Ding, Lu; Zhang, Lei; Monticone, Francesco; Chum, Chan Choy; Deng, Jie; Mei, Shengtao; Li, Ying; Teng, Jinghua; Hong, Minghui; Zhang, Shuang; Alù, Andrea; Qiu, Cheng-Wei

    2016-01-01

    Metasurfaces operating in the cross-polarization scheme have shown an interesting degree of control over the wavefront of transmitted light. Nevertheless, their inherently low efficiency in visible light raises certain concerns for practical applications. Without sacrificing the ultrathin flat design, we propose a bilayer plasmonic metasurface operating at visible frequencies, obtained by coupling a nanoantenna-based metasurface with its complementary Babinet-inverted copy. By breaking the radiation symmetry because of the finite, yet small, thickness of the proposed structure and benefitting from properly tailored intra- and interlayer couplings, such coupled bilayer metasurface experimentally yields a conversion efficiency of 17%, significantly larger than that of earlier single-layer designs, as well as an extinction ratio larger than 0 dB, meaning that anomalous refraction dominates the transmission response. Our finding shows that metallic metasurface can counterintuitively manipulate the visible light as efficiently as dielectric metasurface (~20% in conversion efficiency in Lin et al.'s study), although the metal's ohmic loss is much higher than dielectrics. Our hybrid bilayer design, still being ultrathin (~λ/6), is found to obey generalized Snell's law even in the presence of strong couplings. It is capable of efficiently manipulating visible light over a broad bandwidth and can be realized with a facile one-step nanofabrication process. PMID:26767195

  3. Viscoelastic changes measured in partially suspended single bilayer membranes.

    Science.gov (United States)

    Hasan, Imad Younus; Mechler, Adam

    2015-07-21

    For studies involving biomimetic phospholipid membrane systems, such as membrane-protein interactions, it is crucial that the supported membrane is biomimetic in its physical properties as well as in its composition. Two often overlooked aspects of biomimicry are the need for unrestrained lipid mobility, reflected in the viscoelastic properties of the membrane, and sufficient space between the membrane and the support for the insertion of transmembrane proteins. Here we show for a series of DMPC-based membranes that a partially suspended single bilayer membrane can be formed on functionalized gold surface without tethering. These membranes exhibit sufficient freedom of motion to represent the viscoelastic properties of a free lamellar bilayer membrane as demonstrated by determining the phase transition temperatures of these single bilayer membranes from the viscosity change upon chain melting using the dissipation signal of a quartz crystal microbalance (QCM-D). Atomic force microscopy imaging confirmed confluent, smooth membrane coverage of the QCM-D sensor that completely obscured the roughness of the sputtered gold surface. High-force AFM imaging was able to push membrane patches into the valleys of the gold morphology, confirming the inherently suspended nature of the MPA supported membrane. We show that the correlation between frequency and dissipation changes in the QCM-D sensograms is a sensitive indicator of the morphology of the membrane. PMID:26073288

  4. Amphotericin B induced interdigitation of apolipoprotein stabilized nanodisk bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, T; Weers, P M; Sulchek, T; Hoeprich, P D; Ryan, R O

    2006-12-07

    Amphotericin B nanodisks (AMB-ND) are ternary complexes of AMB, phospholipid (PL) and apolipoprotein organized as discrete nanometer scale disk-shaped bilayers. In gel filtration chromatography experiments, empty ND lacking AMB elute as a single population of particles with a molecular weight in the range of 200 kDa. AMB-ND formulated at a 4:1 PL:AMB weight ratio, separated into two peaks. Peak 1 eluted at the position of control ND lacking AMB while the second peak, containing all of the AMB present in the original sample, eluted in the void volume. When ND prepared with increased AMB (1:1 phospholipid:AMB molar ratio) were subjected to gel filtration chromatography, an increased proportion of phospholipid and apolipoprotein were recovered in the void volume with the AMB. Prior to gel filtration the AMB-ND sample could be passed through a 0.22 {micro}m filter without loss of AMB while the voided material was lost. Native gel electrophoresis studies corroborated the gel permeation chromatography data. Far UV circular dichroism analyses revealed that apoA-I associated with AMB-ND denatures at a lower guanidine HCl concentration than apoA-I associated with ND lacking AMB. Atomic force microscopy revealed that AMB induces compression of the ND bilayer thickness consistent with bilayer interdigitation, a phenomenon that is likely related to the ability of AMB to induce pore formation in susceptible membranes.

  5. Supercurrent reversal in Josephson junctions based on bilayer graphene flakes

    Science.gov (United States)

    Rameshti, Babak Zare; Zareyan, Malek; Moghaddam, Ali G.

    2015-08-01

    We investigate the Josephson effect in a bilayer graphene flake contacted by two monolayer sheets deposited by superconducting electrodes. It is found that when the electrodes are attached to the different layers of the bilayer, the Josephson current is in a π state, if the bilayer region is undoped and there is no vertical bias. Applying doping or bias to the junction reveals π -0 transitions which can be controlled by varying the temperature and the junction length. The supercurrent reversal here is very different from the ferromagnetic Josephson junctions where the spin degree of freedom plays the key role. We argue that the scattering processes accompanied by layer and sublattice index change give rise to the scattering phases, the effect of which varies with doping and bias. Such scattering phases are responsible for the π -0 transitions. On the other hand, if both of the electrodes are coupled to the same layer of the flake or the flake has AA stacking instead of common AB, the junction will be always in 0 state since the layer or sublattice index is not changed.

  6. Hybrid bilayer plasmonic metasurface efficiently manipulates visible light

    Science.gov (United States)

    Qin, Fei; Ding, Lu; Zhang, Lei; Monticone, Francesco; Chum, Chan Choy; Deng, Jie; Mei, Shengtao; Li, Ying; Teng, Jinghua; Hong, Minghui; Zhang, Shuang; Alù, Andrea; Qiu, Cheng-Wei

    2016-01-01

    Metasurfaces operating in the cross-polarization scheme have shown an interesting degree of control over the wavefront of transmitted light. Nevertheless, their inherently low efficiency in visible light raises certain concerns for practical applications. Without sacrificing the ultrathin flat design, we propose a bilayer plasmonic metasurface operating at visible frequencies, obtained by coupling a nanoantenna-based metasurface with its complementary Babinet-inverted copy. By breaking the radiation symmetry because of the finite, yet small, thickness of the proposed structure and benefitting from properly tailored intra- and interlayer couplings, such coupled bilayer metasurface experimentally yields a conversion efficiency of 17%, significantly larger than that of earlier single-layer designs, as well as an extinction ratio larger than 0 dB, meaning that anomalous refraction dominates the transmission response. Our finding shows that metallic metasurface can counterintuitively manipulate the visible light as efficiently as dielectric metasurface (~20% in conversion efficiency in Lin et al.’s study), although the metal’s ohmic loss is much higher than dielectrics. Our hybrid bilayer design, still being ultrathin (~λ/6), is found to obey generalized Snell’s law even in the presence of strong couplings. It is capable of efficiently manipulating visible light over a broad bandwidth and can be realized with a facile one-step nanofabrication process. PMID:26767195

  7. Soliton-dependent plasmon reflection at bilayer graphene domain walls

    Science.gov (United States)

    Jiang, Lili; Shi, Zhiwen; Zeng, Bo; Wang, Sheng; Kang, Ji-Hun; Joshi, Trinity; Jin, Chenhao; Ju, Long; Kim, Jonghwan; Lyu, Tairu; Shen, Yuen-Ron; Crommie, Michael; Gao, Hong-Jun; Wang, Feng

    2016-08-01

    Layer-stacking domain walls in bilayer graphene are emerging as a fascinating one-dimensional system that features stacking solitons structurally and quantum valley Hall boundary states electronically. The interactions between electrons in the 2D graphene domains and the one-dimensional domain-wall solitons can lead to further new quantum phenomena. Domain-wall solitons of varied local structures exist along different crystallographic orientations, which can exhibit distinct electrical, mechanical and optical properties. Here we report soliton-dependent 2D graphene plasmon reflection at different 1D domain-wall solitons in bilayer graphene using near-field infrared nanoscopy. We observe various domain-wall structures in mechanically exfoliated graphene bilayers, including network-forming triangular lattices, individual straight or bent lines, and even closed circles. The near-field infrared contrast of domain-wall solitons arises from plasmon reflection at domain walls, and exhibits markedly different behaviours at the tensile- and shear-type domain-wall solitons. In addition, the plasmon reflection at domain walls exhibits a peculiar dependence on electrostatic gating. Our study demonstrates the unusual and tunable coupling between 2D graphene plasmons and domain-wall solitons.

  8. Spatial arrangement of selected fluorescence labels in lipid bilayer.

    Science.gov (United States)

    Zawada, Zygmunt H

    2013-08-01

    The method for the determination the orientation factor κ(2), spatial arrangement and depth position of fluorescence labels located in hydrophilic layers of vesicles bilayer from resonance energy transfer (RET) data is presented. The method is based on the broadened Wolber and Hudson RET model in two dimensions (Biophys J. 1979). The vesicles were labeled with N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (NBD-PE) as the donor and N-(Lissamine rhodamine B sulfonyl) 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (NRh-PE) as the acceptor. It was found that in basic environment sodium dithionite quenches fluorescence of both labels located in outer leaflet of bilayer. Therefore, RET data prior to and following dithionite treatment were compared and the donor-acceptor cis and trans distances of the closest approach as well as cis and trans Förster radii R0, and orientation factors κ(2) for cis RET equal to 0.61±0.06 and for trans RET equal to 0.17±0.01 were assigned. Knowing the κ(2) data, the spatial arrangement of NBD and NRh labels as dipoles in dipalmitoylphosphatidylcholine bilayer were described. PMID:23727616

  9. Local membrane mechanics of pore-spanning bilayers.

    Science.gov (United States)

    Mey, Ingo; Stephan, Milena; Schmitt, Eva K; Müller, Martin Michael; Ben Amar, Martine; Steinem, Claudia; Janshoff, Andreas

    2009-05-27

    The mechanical behavior of lipid bilayers spanning the pores of highly ordered porous silicon substrates was scrutinized by local indentation experiments as a function of surface functionalization, lipid composition, solvent content, indentation velocity, and pore radius. Solvent-containing nano black lipid membranes (nano-BLMs) as well as solvent-free pore-spanning bilayers were imaged by fluorescence and atomic force microscopy prior to force curve acquisition, which allows distinguishing between membrane-covered and uncovered pores. Force indentation curves on pore-spanning bilayers attached to functionalized hydrophobic porous silicon substrates reveal a predominately linear response that is mainly attributed to prestress in the membranes. This is in agreement with the observation that indentation leads to membrane lysis well below 5% area dilatation. However, membrane bending and lateral tension dominate over prestress and stretching if solvent-free supported membranes obtained from spreading giant liposomes on hydrophilic porous silicon are indented. An elastic regime diagram is presented that readily allows determining the dominant contribution to the mechanical response upon indentation as a function of load and pore radius. PMID:19453196

  10. Optical and electrical properties of Mg/Co bilayer thin film metal hydrides

    Directory of Open Access Journals (Sweden)

    M. K. JANGID,

    2010-12-01

    Full Text Available Bilayer Mg/Co thin films have been prepared using thermal evaporation method at pressure 10-5 torr. Annealing of bilayer thin films have been performed for 1 hour at different temperature. Hydrogenation of pristine and annealed bilayer structure has been performed at different hydrogen pressure for half an hour. The optical transmission increased with hydrogen pressure and also the band gap of thin films found to be increase with hydrogen pressure. Pristine Mg/Co bilayers show ohmic behavior and conductivity increase with hydrogen pressure. After annealing bilayers show semiconductor nature and conductivity has been found to be increased with annealing temperature and decreased with hydrogenation. Raman spectra of these sample shows decreasing intensity of peaks with annealing and hydrogenation. The relative resistivity varies nonlinearly withtime and increases with hydrogen pressure. Surface morphology of annealed and annealed hydrogenated bilayer structure has been confirmed by optical microscopy.

  11. Graphene Monoxide Bilayer As a High-Performance on/off Switching Media for Nanoelectronics.

    Science.gov (United States)

    Woo, Jungwook; Yun, Kyung-Han; Chung, Yong-Chae

    2016-04-27

    The geometries and electronic characteristics of the graphene monoxide (GMO) bilayer are predicted via density functional theory (DFT) calculations. All the possible sequences of the GMO bilayer show the typical interlayer bonding characteristics of two-dimensional bilayer systems with a weak van der Waals interaction. The band gap energies of the GMO bilayers are predicted to be adequate for electronic device application, indicating slightly smaller energy gaps (0.418-0.448 eV) compared to the energy gap of the monolayer (0.536 eV). Above all, in light of the band gap engineering, the band gap of the GMO bilayer responds to the external electric field sensitively. As a result, a semiconductor-metal transition occurs at a small critical electric field (EC = 0.22-0.30 V/Å). It is therefore confirmed that the GMO bilayer is a strong candidate for nanoelectronics. PMID:27046262

  12. Study of annealing effects in Al–Sb bilayer thin films

    Indian Academy of Sciences (India)

    R K Mangal; B Tripathi; M Singh; Y K Vijay

    2007-02-01

    In this paper, we present preparation and characterization of Al–Sb bilayer thin films. Thin films of thicknesses, 3000/1000 Å and 3000/1500 Å, were obtained by the thermal evaporation (resistive heating) method. Vacuum annealing and rapid thermal annealing methods were used to mix bilayer thin film structure. Results obtained from optical band gap data and Rutherford back scattering spectrometry showed mixing of Al–Sb bilayer system.

  13. Reparameterization of All-Atom Dipalmitoylphosphatidylcholine Lipid Parameters Enables Simulation of Fluid Bilayers at Zero Tension

    OpenAIRE

    Sonne, Jacob; Jensen, Morten Ø.; Hansen, Flemming Y.; Hemmingsen, Lars Bo Stegeager; Peters, Günther H.

    2007-01-01

    Molecular dynamics simulations of dipalmitoylphosphatidylcholine (DPPC) lipid bilayers using the CHARMM27 force field in the tensionless isothermal-isobaric (NPT) ensemble give highly ordered, gel-like bilayers with an area per lipid of ∼48 Å2. To obtain fluid (Lα) phase properties of DPPC bilayers represented by the CHARMM energy function in this ensemble, we reparameterized the atomic partial charges in the lipid headgroup and upper parts of the acyl chains. The new charges were determined ...

  14. Electrowetting on dielectric-based microfluidics for integrated lipid bilayer formation and measurement

    Science.gov (United States)

    Poulos, Jason L.; Nelson, Wyatt C.; Jeon, Tae-Joon; Kim, Chang-Jin ``Cj''; Schmidt, Jacob J.

    2009-07-01

    We present a microfluidic platform for the formation and electrical measurement of lipid bilayer membranes. Using electrowetting on dielectric (EWOD), two or more aqueous droplets surrounded by a lipid-containing organic phase were manipulated into contact to form a lipid bilayer at their interface. Thin-film Ag/AgCl electrodes integrated into the device enabled electrical measurement of membrane formation and the incorporation of gramicidin channels of two bilayers in parallel.

  15. Effects of cholesterol or gramicidin on slow and fast motions of phospholipids in oriented bilayers.

    OpenAIRE

    Peng, Z. Y.; Simplaceanu, V; Dowd, S R; Ho, C.

    1989-01-01

    Nuclear spin-lattice relaxation both in the rotating frame and in the laboratory frame is used to investigate the slow and fast molecular motions of phospholipids in oriented bilayers in the liquid crystalline phase. The bilayers are prepared from a perdeuterated phospholipid labeled with a pair of 19F atoms at the 7 position of the 2-sn acyl chain. Phospholipid-cholesterol or phospholipid-gramicidin interactions are characterized by measuring the relaxation rates as a function of the bilayer...

  16. High Yield Chemical Vapor Deposition Growth of High Quality Large-Area AB Stacked Bilayer Graphene

    OpenAIRE

    Liu, Lixin; Zhou, Hailong; Cheng, Rui; Yu, Woo Jong; Liu, Yuan; Chen, Yu; Shaw, Jonathan; Zhong, Xing; Huang, Yu; Duan, Xiangfeng

    2012-01-01

    Bernal stacked (AB stacked) bilayer graphene is of significant interest for functional electronic and photonic devices due to the feasibility to continuously tune its band gap with a vertical electrical field. Mechanical exfoliation can be used to produce AB stacked bilayer graphene flakes but typically with the sizes limited to a few micrometers. Chemical vapor deposition (CVD) has been recently explored for the synthesis of bilayer graphene but usually with limited coverage and a mixture of...

  17. The isolated ciliary bilayer is useful for studies of aqueous humor formation.

    OpenAIRE

    Sears, M L; Yamada, E.; Cummins, D; Mori, N; Mead, A.; Murakami, M.

    1991-01-01

    An intact ciliary epithelial bilayer has been isolated from the rabbit eye by perfusion, microsurgical dissection, and recovery techniques. Vital subcellular organelles and intercellular junctions of this epithelial bilayer preparation are very well preserved. The total electrical resistance of the epithelial bilayer is 350 ohms, and the transepithelial potential is 650 microV, nonpigmented epithelium side negative. The electrical resistance is reduced by 0.2 mM EGTA and the transepithelial p...

  18. Single DNA molecules on freestanding and supported cationic lipid bilayers: diverse conformational dynamics controlled by the local bilayer properties

    Science.gov (United States)

    Herold, Christoph; Schwille, Petra; Petrov, Eugene P.

    2016-02-01

    We present experimental results on the interaction of DNA macromolecules with cationic lipid membranes with different properties, including freestanding membranes in the fluid and gel state, and supported lipid membranes in the fluid state and under conditions of fluid-gel phase coexistence. We observe diverse conformational dynamics of membrane-bound DNA molecules controlled by the local properties of the lipid bilayer. In case of fluid-state freestanding lipid membranes, the behaviour of DNA on the membrane is controlled by the membrane charge density: whereas DNA bound to weakly charged membranes predominantly behaves as a 2D random coil, an increase in the membrane charge density leads to membrane-driven irreversible DNA collapse and formation of subresolution-sized DNA globules. On the other hand, electrostatic binding of DNA macromolecules to gel-state freestanding membranes leads to completely arrested diffusion and conformational dynamics of membrane-adsorbed DNA. A drastically different picture is observed in case of DNA interaction with supported cationic lipid bilayers: When the supported bilayer is in the fluid state, membrane-bound DNA molecules undergo 2D translational Brownian motion and conformational fluctuations, irrespectively of the charge density of the supported bilayer. At the same time, when the supported cationic membrane shows fluid-gel phase coexistence, membrane-bound DNA molecules are strongly attracted to micrometre-sized gel-phase domains enriched with the cationic lipid, which results in 2D compaction of the membrane-bound macromolecules. This DNA compaction, however, is fully reversible, and disappears as soon as the membrane is heated above the fluid-gel coexistence. We also discuss possible biological implications of our experimental findings.

  19. Positively charged supported lipid bilayer formation on gold surfaces for neuronal cell culture.

    Science.gov (United States)

    Choi, Sung-Eun; Greben, Kyrylo; Wördenweber, Roger; Offenhäusser, Andreas

    2016-06-01

    Supported lipid bilayers are widely used as cell membrane models and sensor platforms, but the usage on gold surface needs additional surface modification or optimized experimental conditions. In this work, the authors show lipid bilayer formation on plasma activated gold surfaces in physiological conditions without any other modification if at least 30% positively charged lipids are present. Details of bilayer formation from small unilamellar vesicles were monitored using quartz crystal microbalance with dissipation in both basic and acidic environment. The authors also confirmed that this positively charged bilayer system can sustain primary cortical neuron growth and lipid transfer. This method will provide simple means to construct biomimetic interface on gold electrodes. PMID:27052005

  20. MARTINI Coarse-Grained Model of Triton TX-100 in Pure DPPC Monolayer and Bilayer Interfaces.

    Science.gov (United States)

    Pizzirusso, Antonio; De Nicola, Antonio; Milano, Giuseppe

    2016-04-28

    The coarse-grained MARTINI model of Triton TX-100 has been validated by direct comparison of the experimental and calculated area increase in pure DPPC lipid bilayers and monolayers at water/air interfaces in the presence of surfactant and by comparison of electron density profiles calculated with more detailed atomistic models based on the CHARMM force field. Bilayer simulations have been performed and compared with monolayers and with atomistic models. The validated CG model has been employed to study the phase separation of TX-100 molecules in lipid bilayers and the effect of the lipid bilayer curvature. PMID:27042862

  1. Lindane Suppresses the Lipid-bilayer Permeability in Main Transition Region

    DEFF Research Database (Denmark)

    Sabra, Mads Christian; Jørgensen, Kent; Mouritsen, Ole G.

    1996-01-01

    the transition and lower the transition temperature, without changing the transition enthalpy significantly. Lindane therefore enhances the thermal fluctuations of the bilayer. The calorimetric data furthermore suggest that the bilayer structure is intact and not disrupted by even high concentrations (32 mol......%) of lindane. Fluorescence spectroscopy was used to measure the passive permeability of unilamellar DMPC bilayers to Co2+ ions. The data show that lindane seals the bilayer for Co2+ penetration and that this effect increases with increasing lindane concentration. The results are discussed in relation...

  2. A bridge to advanced mathematics

    CERN Document Server

    Sentilles, Dennis

    2011-01-01

    This helpful workbook-style ""bridge"" book introduces students to the foundations of advanced mathematics, spanning the gap between a practically oriented calculus sequence and subsequent courses in algebra and analysis with a more theoretical slant. Part 1 focuses on logic and number systems, providing the most basic tools, examples, and motivation for the manner, method, and concerns of higher mathematics. Part 2 covers sets, relations, functions, infinite sets, and mathematical proofs and reasoning. Author Dennis Sentilles also discusses the history and development of mathematics as well a

  3. Fatigue problems of steel bridges

    Czech Academy of Sciences Publication Activity Database

    Urushadze, Shota; Frýba, Ladislav; Škaloud, Miroslav; Pirner, Miroš; Zörnerová, Marie

    Stirlingshire : Civil-Comp Press, 2012 - (Pombo, J.), s. 142-151 ISBN 978-1-905088-53-9. ISSN 1759-3433. [International Conference on Railway Technology: Research, Development and Maintenance /1./. Las Palmas de Gran Canaria (ES), 18.04.2012-20.04.2012] R&D Projects: GA MŠk(CZ) 7E08098 Grant ostatní: evropská komise(XE) RFSR-CT-2008-00033 (BRIFAG); GA ČR(CZ) GA103/08/1340 Institutional support: RVO:68378297 Keywords : steel bridges * fatigue * S-N curve * orthotropic deck * web breathing Subject RIV: JM - Building Engineering

  4. Nanoclusters a bridge across disciplines

    CERN Document Server

    Jena, Purusottam

    2010-01-01

    This comprehensive book on Nanoclusters comprises sixteen authoritative chapters written by leading researchers in the field. It provides insight into topics that are currently at the cutting edge of cluster science, with the main focus on metal and metal compound systems that are of particular interest in materials science, and also on aspects related to biology and medicine. While there are numerous books on clusters, the focus on clusters as a bridge across disciplines sets this book apart from others. Delivers cutting edge coverage of cluster science Covers a broad range of topics in

  5. Seismic Evaluation of Highway Bridges - Phase 1

    OpenAIRE

    Ramirez, J.A.; Pan, Austin D.; Mwakasisi, Frank Thompson

    1996-01-01

    The primary objective of the study was to establish the guidelines for screening, assessing, and ranking Indiana bridges for seismic upgrade. The outcome of the study is a complete strategy for the detailed structural assessment of Indiana highway bridges subjected to seismic forces. The structural evaluation is conducted using a nonlinear time-history analysis of the bridge for simulated or actual records. The specific soil conditions at the site are accounted in terms of the ground motio...

  6. REPORT: BioMedBridges standards workshop

    OpenAIRE

    Conte, Nathalie; Hancocks, Tom; Suhr, Stephanie

    2014-01-01

    This workshop, co-organized by BioMedBridges WP3 and 12, was held on 24-25 June and hosted by BioMedBridges partners at VUMC in Amsterdam. Attendees included BioMedBridges personnel, members from the ESFRI BMS research infrastructures and invited external experts from existing standards organisations. The following aspects of data standardisation were explored: Defining entity identifiers and identifiers best practice Development of a Meta models and Mappings Registry for bio...

  7. Bridges and wildlife: issues and solutions

    OpenAIRE

    Carey, Marion

    2003-01-01

    The Washington State Department of Transportation (WSDOT) owns over 3,000 steel and concrete bridges, many of which are occupied by wildlife. Species documented occupying bridges range from birds of prey, such as ospreys, peregrines and owls, to mammals such as raccoons, bats and bushy tailed wood rats. While the bridges are playing an important role in providing habitat for wildlife, their presence can also lead to costly project delays. Project Objective The project objective is to develop ...

  8. Markovian Bridges: Weak continuity and pathwise constructions

    OpenAIRE

    Chaumont, Loïc; Uribe Bravo, Gerónimo

    2009-01-01

    A Markovian bridge is a probability measure taken from a disintegration of the law of an initial part of the path of a Markov process given its terminal value. As such, Markovian bridges admit a natural parameterization in terms of the state space of the process. In the context of Feller processes with continuous transition densities, we construct by weak convergence considerations the only versions of Markovian bridges which are weakly continuous with respect to their parameter. We use this ...

  9. Bridge Engineering-Oriented Parametric Model

    Institute of Scientific and Technical Information of China (English)

    周凌远; 李乔

    2004-01-01

    A new model is proposed to improve the efficiency of structural modeling. In this model, the bridge structural components are expressed with component description, parametric description and geometric description in a software system. This model provides both convenience and flexibility for users in structural modeling process. The object-oriented method is applied in the model implementation. A bridge analysis preprocessor is developed on the basis of this model. It provides an effective way for bridge modeling.

  10. Maximal liquid bridges between horizontal cylinders

    OpenAIRE

    Cooray, Himantha; Huppert, Herbert E.; Neufeld, Jerome A

    2016-01-01

    We investigate two-dimensional liquid bridges trapped between pairs of identical horizontal cylinders. The cylinders support forces due to surface tension and hydrostatic pressure which balance the weight of the liquid. The shape of the liquid bridge is determined by analytically solving the nonlinear Laplace-Young equation. Parameters that maximize the trapping capacity (defined as the cross-sectional area of the liquid bridge) are then determined. The results show that these parameters can ...

  11. Bridge engineering handbook construction and maintenance

    CERN Document Server

    Chen, Wai-Fah

    2014-01-01

    Over 140 experts, 14 countries, and 89 chapters are represented in the second edition of the Bridge Engineering Handbook. This extensive collection highlights bridge engineering specimens from around the world, contains detailed information on bridge engineering, and thoroughly explains the concepts and practical applications surrounding the subject.Published in five books: Fundamentals, Superstructure Design, Substructure Design, Seismic Design, and Construction and Maintenance, this new edition provides numerous worked-out examples that give readers step-by-step design procedures, includes c

  12. Life Cycle Assessment of a Norwegian Bridge

    OpenAIRE

    Dequidt, Thomas Charles Edouard

    2012-01-01

    Life cycle assessment (LCA) methodology aims at evaluating the environmental impacts of a product or system from a holistic approach. In this methodology, all life cycle phases of the product are identified and assessed, from the raw material acquisition to the end-of-life phase. This master thesis is dealing with the LCA of a Norwegian bridge. First, a literature review is realized by going through 14 bridge LCA references. Then, a detailed description of bridge LCA methodology ...

  13. Measurement of Deflection Line on Bridges

    Science.gov (United States)

    Urban, Rudolf; Štroner, Martin

    2013-12-01

    Prestressed concrete bridges are very sensitive to the increase in long-term deflections. Reliable forecasts of deflections of bridge structures during construction and durability are crucial for achieving good durability. The main results of measurements are the changes of the deflection line of the bridge structures, which places special demands on the measurement procedure. Results from measurements are very useful for the improvement of mathematical prediction methods of behaviour of long span prestressed concrete structures.

  14. Axisymmetric long liquid bridges stability and resonances

    OpenAIRE

    Meseguer Ruiz, José; Sanz Andres, Angel Pedro; Perales Perales, José Manuel

    1990-01-01

    In this paper mathematical expressions for minimum-volume stability limits and resonance frequencies of axisymmetric long liquid bridges are presented. These expressions are valid for a wide range of liquid bridge configurations, accounting for ef-fects like unequal disks and axial microgravity in the case of minimum-volume stability limits,and unequal disks, axial microgravity,non-zero viscosity and liquid bridge volume different from the cylindrical one in the case of resonance frequenc...

  15. Myocardial bridges: morphological and functional aspects.

    OpenAIRE

    A.G. Ferreira; Trotter, S E; König, B; Décourt, L V; Fox, K; Olsen, E G

    1991-01-01

    OBJECTIVE--To assess the arrangement of myocardial bridges. DESIGN--A necropsy study of 90 consecutive hearts (56 male, 34 female). RESULTS--Myocardial bridges, either single or multiple, were seen in 50 (55.6%) of the 90 hearts. The left anterior descending artery was the most commonly affected artery. Thirty five of the 50 hearts which contained in total 41 muscle bridges were dissected further with a magnifying glass. Two different types of muscle bridges could be identified. Thirty one of...

  16. Review of Energy Harvesters Utilizing Bridge Vibrations

    Directory of Open Access Journals (Sweden)

    Farid Ullah Khan

    2016-01-01

    Full Text Available For health monitoring of bridges, wireless acceleration sensor nodes (WASNs are normally used. In bridge environment, several forms of energy are available for operating WASNs that include wind, solar, acoustic, and vibration energy. However, only bridge vibration has the tendency to be utilized for embedded WASNs application in bridge structures. This paper reports on the recent advancements in the area of vibration energy harvesters (VEHs utilizing bridge oscillations. The bridge vibration is narrowband (1 to 40 Hz with low acceleration levels (0.01 to 3.8 g. For utilization of bridge vibration, electromagnetic based vibration energy harvesters (EM-VEHs and piezoelectric based vibration energy harvesters (PE-VEHs have been developed. The power generation of the reported EM-VEHs is in the range from 0.7 to 1450000 μW. However, the power production by the developed PE-VEHs ranges from 0.6 to 7700 μW. The overall size of most of the bridge VEHs is quite comparable and is in mesoscale. The resonant frequencies of EM-VEHs are on the lower side (0.13 to 27 Hz in comparison to PE-VEHs (1 to 120 Hz. The power densities reported for these bridge VEHs range from 0.01 to 9539.5 μW/cm3 and are quite enough to operate most of the commercial WASNs.

  17. Risk assessment of strait crossing bridges

    OpenAIRE

    Forsnes, Mari Krogness

    2015-01-01

    The purpose of this thesis is to try to provide an overall risk picture for the planned strait cross- ing (SC) bridges on coastal highway E39 between Trondheim and Kristiansand in Norway. The thesis starts off by explaining the concepts and solutions of SC bridges to understand what the National Public Road Administration (NPRA) is planning to accomplish with the coastal high- way E39. The SC bridges cannot be compared to any other bridge structures in the world, which will lead to some chall...

  18. 33 CFR 118.140 - Painting bridge piers.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Painting bridge piers. 118.140 Section 118.140 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.140 Painting bridge piers. The District Commander may require painting the sides of bridge channel piers...

  19. 23 CFR 650.409 - Evaluation of bridge inventory.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Evaluation of bridge inventory. 650.409 Section 650.409... Evaluation of bridge inventory. (a) Sufficiency rating of bridges. Upon receipt and evaluation of the bridge inventory, a sufficiency rating will be assigned to each bridge by the Secretary in accordance with...

  20. 49 CFR 237.101 - Scheduling of bridge inspections.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Scheduling of bridge inspections. 237.101 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.101 Scheduling of bridge inspections. (a) Each bridge management program shall include a provision for scheduling...

  1. 33 CFR 118.85 - Lights on vertical lift bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on vertical lift bridges... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.85 Lights on vertical lift bridges. (a) Lift span lights. The vertical lift span of every vertical lift bridge shall be lighted so that the center of...

  2. The Influence of Lipid Bilayer Physicochemical Properties on Gramicidin A Conformer Preferences.

    Science.gov (United States)

    Patrick, John W; Gamez, Roberto C; Russell, David H

    2016-04-26

    The conformational preferences adopted by gramicidin A (GA) dimers inserted into phospholipid bilayers are reported as a function of the bilayer cholesterol content, temperature, and incubation time. Through use of vesicle capture-freeze drying methodology, GA dimers were captured in lipid bilayers and the conformational preferences of the complex were analyzed using ion mobility-mass spectrometry. Perturbations that affect the physicochemical interactions in the lipid bilayer such as cholesterol incorporation, temperature, and incubation time directly alter the conformer preferences of the complex. Regardless of bilayer cholesterol concentration, the antiparallel double helix (ADH) conformation was observed to be most abundant for GA dimers in bilayers composed of lipids with 12 to 22 carbon acyl chains. Incorporation of cholesterol into lipid bilayers yields increased bilayer thickness and rigidity, and an increased abundance of parallel double helix (PDH) and single-stranded head-to-head (SSHH) dimers were observed. Bilayers prepared using 1,2-dilauroyl-sn-glycero-3-phosphocholine, a lipid with 12 carbon acyl chains, yielded a nascent conformer that decreased in abundance as a function of bilayer cholesterol content. High resolution ion mobility-mass spectrometry data revealed two peaks in the ADH region suggesting that ADH populations are composed of two distinct conformers. The conformer preferences of GA dimers from 1,2-distearoyl-sn-glycero-3-phosphocholine bilayers were significantly different for samples incubated at 4°C vs. 60°C; increased cholesterol content yielded more PDH and SSHH at 60°C. The addition of cholesterol as well as incubating samples of 1,2-distearoyl-sn-glycero-3-phosphocholine at 60°C for 24-72 h yielded an increase in PDH and SSHH abundance. PMID:27119642

  3. Stress Transfer and Structural Failure of Bilayered Material Systems

    Science.gov (United States)

    Prieto-Munoz, Pablo Arthur

    Bilayered material systems are common in naturally formed or artificially engineered structures. Understanding how loads transfer within these structural systems is necessary to predict failure and develop effective designs. Existing methods for evaluating the stress transfer in bilayered materials are limited to overly simplified models or require experimental calibration. As a result, these methods have failed to accurately account for such structural failures as the creep induced roofing panel collapse of Boston's I-90 connector tunnel, which was supported by adhesive anchors. The one-dimensional stress analyses currently used for adhesive anchor design cannot account for viscoelastic creep failure, and consequently results in dangerously under-designed structural systems. In this dissertation, a method for determining the two-dimensional stress and displacement fields for a generalized bilayered material system is developed, and proposes a closed-form analytical solution. A general linear-elastic solution is first proposed by decoupling the elastic governing equations from one another through the so-called plane assumption. Based on this general solution, an axisymmetric problem and a plane strain problem are formulated. These are applied to common bilayered material systems such as: (1) concrete adhesive anchors, (2) material coatings, (3) asphalt pavements, and (4) layered sedimentary rocks. The stress and displacement fields determined by this analytical analysis are validated through the use of finite element models. Through the correspondence principle, the linear-elastic solution is extended to consider time-dependent viscoelastic material properties, thus facilitating the analysis of adhesive anchors and asphalt pavements while incorporating their viscoelastic material behavior. Furthermore, the elastic stress analysis can explain the fracturing phenomenon of material coatings, pavements, and layered rocks, successfully predicting their fracture

  4. Effects of Dipole Potential Modifiers on Heterogenic Lipid Bilayers.

    Science.gov (United States)

    Efimova, Svetlana S; Malev, Valery V; Ostroumova, Olga S

    2016-04-01

    In this work, we examine the ability of dipole modifiers, flavonoids, and RH dyes to affect the dipole potential (φ d) and phase separation in membranes composed of ternary mixtures of POPC with different sphingolipids and sterols. Changes in the steady-state conductance induced by cation-ionophore complexes have been measured to evaluate the changes in dipole potential of planar lipid bilayers. Confocal fluorescence microscopy has been employed to investigate lipid segregation in giant unilamellar vesicles. The effects of flavonoids on φ d depend on lipid composition and dipole modifier type. The effectiveness of RH dyes to increase φ d depends on sphingolipid type but is not influenced by sterol content. Tested modifiers lead to partial or complete disruption of gel domains in bilayers composed of POPC, sphingomyelin, and cholesterol. Substitution of cholesterol to ergosterol or 7-dehydrocholesterol leads to a loss of fluidizing effects of modifiers except phloretin. This may be due to various compositions of gel domains. The lack of influence of modifiers on phase scenario in vesicles composed of ternary mixtures of POPC, cholesterol, and phytosphingosine or sphinganine is related to an absence of gel-like phase. It was concluded that the membrane lateral heterogeneity affects the dipole-modifying abilities of the agents that influence the magnitude of φ d by intercalation into the bilayer and orientation of its own large dipole moments (phloretin and RH dyes). The efficacy of modifiers that do not penetrate deeply and affect φ d through water adsorption (phlorizin, quercetin, and myricetin) is not influenced by lateral heterogeneity of membrane. PMID:26454655

  5. Electromagnetic coupling of spins and pseudospins in bilayer graphene

    Science.gov (United States)

    Winkler, R.; Zülicke, U.

    2015-05-01

    We present a detailed theoretical study of bilayer-graphene's electronic properties in the presence of electric and magnetic fields. Using group-theoretical methods, we derive an invariant expansion of the Hamiltonian for electron states near the K point of the Brillouin zone. In contrast to known materials, including single-layer graphene, any possible coupling of physical quantities to components of the external electric (magnetic) field has a counterpart where the analogous component of the magnetic (electric) field couples to exactly the same combination of quantities. For example, a purely electric spin splitting appears as the magnetoelectric analog of the familiar magnetic Zeeman spin splitting. The measurable thermodynamic response induced by magnetic and electric fields is thus completely symmetric. The Pauli magnetization induced by a magnetic field takes exactly the same functional form as the polarization induced by an electric field. Our findings thus reveal unconventional behavior of spin and pseudospin degrees of freedom in their coupling to external fields. We explain how these counterintuitive couplings are consistent with fundamental principles such as time reversal symmetry. For example, only a magnetic field can give rise to a macroscopic spin polarization, whereas only a perpendicular electric field can induce a macroscopic polarization of the sublattice-related pseudospin degree of freedom characterizing the intravalley orbital motion in bilayer graphene. These rules enforced by symmetry for the matter-field interactions clarify the nature of spins versus pseudospins. We also provide numerical values of prefactors for relevant coupling terms. While our theoretical arguments use bilayer graphene as an example, they are generally valid for any material with similar symmetries. The unusual equivalence of magnetic and electric fields discussed here can provide the basis for designing more versatile device architectures for creating polarizations

  6. Bridge weigh-in-motion on steel orthotropic decks and application to bridge assessment

    OpenAIRE

    Jacob, Bernard; Ieng, Sio Song; SCHMIDT, Franziska

    2012-01-01

    Bridge weigh-in-motion uses an instrumented bridge as a scale to weigh vehicles. Several types of bridges may be used, if being sensitive to wheel or axle loads. Here some strains of steel orthotropic deck bridges are measured by extensometers and analyzed by software, to calculate axle loads and gross vehicle weights. Between 2009 and 2011, several large scale tests were done on the Millau viaduct (France), the tallest cable stayed bridge in the world. These tests showed that the system meet...

  7. Bridge Lock-up Device System

    OpenAIRE

    ECT Team, Purdue

    2007-01-01

    The Colebrand Lock-up Device (LUD) provides additional substructure strength to resist seismic forces as a structural shock transmission unit for highway bridges. This system can provide a temporary rigid link between bridge structural members under seismic, braking, or other fast-acting type loads, while permitting slow thermal movements.

  8. Analysis of Biaxially Stressed Bridge Deck Plates

    DEFF Research Database (Denmark)

    Jönsson, Jeppe; Bondum, Tommi Højer

    The ultimate state analysis of bridge deck plates at the intersection zone between main girders and transverse beams is complicated by biaxial membrane stresses, which may be in compression or tension in either direction depending on the bridge configuration and the specific location. This paper ...

  9. Re-Assessment of Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper two aspects of re-assessment of the reliability of concrete bridges are discussed namely modelling of the corrosion of reinforcement and updating of uncertain variables. The main reason for deterioration of concrete bridges is corrosion of the reinforcement. Therefore, modelling of...

  10. Paul Dirac:. Building Bridges of the Mind

    Science.gov (United States)

    Brown, Laurie M.

    2003-12-01

    Paul Dirac was a brilliant and original thinker. He used his physical intuition and his ideal of mathematical beauty to construct bridges between major areas of physics. This article discusses several such important works, including the bridge between quantum mechanics and relativity that led to his prediction of the existence of antimatter.

  11. Fast response Full Bridge Power Factor Corrector

    OpenAIRE

    Chan, CH; Pong, MH

    1998-01-01

    A fast response Full Bridge Power Factor Corrector (FBPFC) is presented in this paper. The converter is combined by two interleaved boost cells and a conventional full bridge converter. As the interleaving technique is applied, the input ripple current of FBPFC are reduced. Experimental result shows that the maximum power factor is 0.98 even without input filter.

  12. A STUDY OF BARRIERS IN BRIDGING COMMUNICATION

    OpenAIRE

    Niteen V. Dandekar

    2014-01-01

    The main objective of this paper is to make a thought provoking discussion on the role barriers in bridging communication. It focuses on the concept of communication, process and the role of language related barriers in bridging communication. It studies the significance of communication in modern human life.

  13. Heavy Vehicles on Minor Highway Bridges

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Nielsen, Søren R. K.; Enevoldsen, I.

    the results obtained using the numerical models given in details in "Heavy Vehicles on Minor Highway Bridges : dynamic modelling of vehicles and bridges". The models are established using a ordinary vehicle which consists of a 48 t Scania with a 3 axle tractor and a 3 axle trailer, joined in a flexible hinge...

  14. General framework for bridge life cycle design

    Institute of Scientific and Technical Information of China (English)

    Junhai MA; Airong CHEN; Jun HE

    2009-01-01

    Based on a detailed illustration for bridge life cycle design which comprises the processes of service life design, aesthetics design, performance design, environ-mental and ecological design, inspection, maintenance and repair design as well as cost analysis, this paper presented a general framework for bridge life cycle design comprising three design phases and six design processes.

  15. History of cable-stayed bridges

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    The principle of supporting a bridge deck by inclined tension members leading to towers on either side of the span has been known for centuries. However, the real development of cable-stayed bridges did not begin before the 1950s. Since then the free span has been increased from 183 m in the Strö...

  16. COUPLING VIBRATION OF VEHICLE-BRIDGE SYSTEM

    Institute of Scientific and Technical Information of China (English)

    陈炎; 黄小清; 马友发

    2004-01-01

    By applying the sinusoidal wave mode to simulate the rugged surface of bridge deck,accounting for vehicle-bridge interaction and using Euler-Bernoulli beam theory, a coupling vibration model of vehicle-bridge system was developed. The model was solved by mode analyzing method and Runge-Kutta method, and the dynamic response and the resonance curve of the bridge were obtained. It is found that there are two resonance regions, one represents the main resonance while the other the minor resonance, in the resonance curve. The influence due to the rugged surface, the vibration mode of bridge, and the interaction between vehicle and bridge on vibration of the system were discussed. Numerical results show that the influence due to these parameters is so significant that the effect of roughness of the bridge deck and the mode shape of the bridge can't be ignored and the vehicle velocity should be kept away from the critical speed of the vehicle.

  17. Molecular dynamics simulation of DPPC bilayer in DMSO.

    OpenAIRE

    Smondyrev, A M; Berkowitz, M L

    1999-01-01

    We performed molecular dynamics simulations on dipalmitoylphosphatidylcholine (DPPC)/dimethylsulfoxide (DMSO) system that has the same lipid:solvent weight ratio as in our previous simulation done on DPPC/water. We did not observe a large change in the size of DPPC membrane when the solvent was changed from water to DMSO. Also, we did not observe that a large number of DMSO molecules is permeating into the membrane, as it was suggested to explain the observed change in the bilayer repeat peri...

  18. Photoinduced electron transfer of chlorophyll in lipid bilayer system

    Indian Academy of Sciences (India)

    D K Lee; K W Seo; Y S Kang

    2002-12-01

    Photoinduced electron transfer from chlorophyll- through the interface of dipalmitoylphosphatidylcholine (DPPC) headgroup of the lipid bilayers was studied with electron magnetic resonance (EMR). The photoproduced radicals were identified with electron spin resonance (ESR) and radical yields of chlorophyll- were determined by double integration ESR spectra. The formation of vesicles was identified by changes in measured max values from diethyl ether solutions to vesicles solutions indirectly, and observed directly with SEM and TEM images. The efficiency of photosynthesis in model system was determined by measuring the amount of chlorophyll-a radical yields which were obtained from integration of ESR spectra.

  19. The sting. Melittin forms channels in lipid bilayers.

    OpenAIRE

    Tosteson, M T; Tosteson, D. C.

    1981-01-01

    Melittin, a toxin of bee venom, is a cationic polypeptide composed of 26 amino acids. The six residues of the C-terminal end are polar and 19 of the 20 residues of the N-terminal end are hydrophobic. Exposure of the lecithin bilayer to melittin results in the formation of channels that are more permeable to anions that to cations. Unilateral addition of melittin produces a voltage-dependent increase in membrane conductance when the side where the polypeptide is present in made positive but no...

  20. Negative terahertz conductivity in remotely doped graphene bilayer heterostructures

    International Nuclear Information System (INIS)

    Injection or optical generation of electrons and holes in graphene bilayers (GBLs) can result in the interband population inversion enabling the terahertz (THz) radiation lasing. The intraband radiative processes compete with the interband transitions. We demonstrate that remote doping enhances the indirect interband generation of photons in the proposed GBL heterostructures. Therefore, such remote doping helps to surpass the intraband (Drude) absorption, and results in large absolute values of the negative dynamic THz conductivity in a wide range of frequencies at elevated (including room) temperatures. The remotely doped GBL heterostructure THz lasers are expected to achieve higher THz gain compared with previously proposed GBL-based THz lasers

  1. Planar-bilayer activities of linear oligoester bolaamphiphiles

    Directory of Open Access Journals (Sweden)

    Jonathan K. W. Chui

    2011-11-01

    Full Text Available Voltage-clamp experiments of eight oligoester bolaamphiphiles in two subclasses are described. Syntheses of three new terephthalate-based compounds were achieved in three linear steps. Together with five previously described, related compounds, the ion transport activity was assessed by means of the voltage-clamp technique. All of the compounds show multiple types of conductance behavior in planar bilayers, a subset of which was exponentially voltage-dependent. The varied and irregular activities were summarized with the aid of a recently developed “activity-grid” method.

  2. Study of ion transports across model phospholipid bilayers

    Czech Academy of Sciences Publication Activity Database

    Navrátil, Tomáš; Šestáková, Ivana; Mareček, Vladimír

    Brno : PřF Masarykovy univerzity, 2009, s. 106-108. ISBN 978-80-7375-309-2. [Pracovní setkání fyzikálních chemiků a elektrochemiků /9./. Brno (CZ), 29.06.2009-30.06.2009] R&D Projects: GA AV ČR IAA400400806 Institutional research plan: CEZ:AV0Z40400503 Keywords : supported phospholipid bilayer * transport of charged particles * voltammetry * electrochemical impedance spectroscopy Subject RIV: CG - Electrochemistry

  3. Superior thermal conductivity in suspended bilayer hexagonal boron nitride

    Science.gov (United States)

    Wang, Chengru; Guo, Jie; Dong, Lan; Aiyiti, Adili; Xu, Xiangfan; Li, Baowen

    2016-05-01

    We reported the basal-plane thermal conductivity in exfoliated bilayer hexagonal boron nitride h-BN that was measured using suspended prepatterned microstructures. The h-BN sample suitable for thermal measurements was fabricated by dry-transfer method, whose sample quality, due to less polymer residues on surfaces, is believed to be superior to that of PMMA-mediated samples. The measured room temperature thermal conductivity is around 484 Wm‑1K‑1(+141 Wm‑1K‑1/ ‑24 Wm‑1K‑1) which exceeds that in bulk h-BN, providing experimental observation of the thickness-dependent thermal conductivity in suspended few-layer h-BN.

  4. Phase Diagram of Antiferromagnetically Exchange-Coupled Bilayer

    Institute of Scientific and Technical Information of China (English)

    GUO Guang-Hua; ZHANG Guang-Fu; SUN Li-Yuan; Peter A. J. de Groot

    2008-01-01

    Magnetic hysteresis properties of antiferromagnetically exchange-coupled bilayer structures, in which the two magnetic layers have different magnetic parameters and thicknesses, are studied within the framework of the Stoner-Wohifarth model. Analytical expressions for the switching fields corresponding to the linear magnetic states are obtained. By adjusting the magnetic parameters or thicknesses of layers, nine different types of easyaxis hysteresis loops may exist. The phase diagram of easy-axis hysteresis loops is mapped in the k,1 and k,2 plane, where k,1 and k,2 are the ratios of magnetic anisotropy to the interlayer exchange coupling of the two magnetic layers, respectively.

  5. Tailored sequential drug release from bilayered calcium sulfate composites

    Energy Technology Data Exchange (ETDEWEB)

    Orellana, Bryan R.; Puleo, David A., E-mail: puleo@uky.edu

    2014-10-01

    The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt.%) of metronidazole-loaded poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography showed the overall layered geometry as well as the uniform distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (i.e., 1 vs. 10 wt.%) had a small but significant effect on the erosion rate (3% vs. 3.4%/d). Mechanical testing determined that introducing a layered geometry had a significant effect on the compressive strength, with an average reduction of 35%, but properties were comparable to those of mandibular trabecular bone. Sustained release of simvastatin directly loaded into CS demonstrated that changing the shell to core volume ratio dictates the duration of drug release from each layer. When loaded together in the shell or in separate layers, sequential release of metronidazole and simvastatin was achieved. By introducing a tunable, layered geometry capable of releasing multiple drugs, CS-based bone graft substitutes could be tailored in order to help streamline the multiple steps needed to regenerate tissue in infected defects. - Highlights: • Bilayered CS composites were fabricated as potential bone graft substitutes. • The shell

  6. Negative terahertz conductivity in remotely doped graphene bilayer heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Ryzhii, V. [Research Institute of Electrical Communication, Tohoku University, Sendai 980-8577 (Japan); Institute of Ultra High Frequency Semiconductor Electronics of RAS, and Center for Photonics and Infrared Engineering, Bauman Moscow State Technical University, Moscow 111005 (Russian Federation); Ryzhii, M. [Department of Computer Science and Engineering, University of Aizu, Aizu-Wakamatsu 965-8580 (Japan); Mitin, V. [Department of Electrical Engineering, University at Buffalo, SUNY, Buffalo, New York 1460-1920 (United States); Shur, M. S. [Departments of Electrical, Electronics, and Systems Engineering and Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States); Otsuji, T. [Research Institute of Electrical Communication, Tohoku University, Sendai 980-8577 (Japan)

    2015-11-14

    Injection or optical generation of electrons and holes in graphene bilayers (GBLs) can result in the interband population inversion enabling the terahertz (THz) radiation lasing. The intraband radiative processes compete with the interband transitions. We demonstrate that remote doping enhances the indirect interband generation of photons in the proposed GBL heterostructures. Therefore, such remote doping helps to surpass the intraband (Drude) absorption, and results in large absolute values of the negative dynamic THz conductivity in a wide range of frequencies at elevated (including room) temperatures. The remotely doped GBL heterostructure THz lasers are expected to achieve higher THz gain compared with previously proposed GBL-based THz lasers.

  7. Inverse Proximity Effect in Superconductor-ferromagnet Bilayer Structures

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Jing

    2010-04-05

    Measurements of the polar Kerr effect using a zero-area-loop Sagnac magnetometer on Pb/Ni and Al/(Co-Pd) proximity-effect bilayers show unambiguous evidence for the 'inverse proximity effect,' in which the ferromagnet (F) induces a finite magnetization in the superconducting (S) layer. To avoid probing the magnetic effects in the ferromagnet, the superconducting layer was prepared much thicker than the light's optical penetration depth. The sign and size of the effect, as well as its temperature dependence agree with recent predictions by Bergeret et al.[1].

  8. Application of pressure perturbation calorimetry to lipid bilayers.

    OpenAIRE

    Heerklotz, Heiko; Seelig, Joachim

    2002-01-01

    Pressure perturbation calorimetry (PPC) is a new method that measures the heat consumed or released by a sample after a sudden pressure jump. The heat change can be used to derive the thermal volume expansion coefficient, alpha(V), as a function of temperature and, in the case of phase transitions, the volume change, DeltaV, occurring at the phase transition. Here we present the first report on the application of PPC to determine these quantities for lipid bilayers. We measure the volume chan...

  9. Lipid bilayer array for simultaneous recording of ion channel activities

    Science.gov (United States)

    Hirano-Iwata, Ayumi; Nasu, Tomohiro; Oshima, Azusa; Kimura, Yasuo; Niwano, Michio

    2012-07-01

    This paper describes an array of stable and reduced-solvent bilayer lipid membranes (BLMs) formed in microfabricated silicon chips. BLMs were first vertically formed simultaneously and then turned 90° in order to realize a horizontal BLM array. Since the present BLMs are mechanically stable and robust, the BLMs survive this relatively tough process. Typically, a ˜60% yield in simultaneous BLM formation over 9 sites was obtained. Parallel recordings of gramicidin channel activities from different BLMs were demonstrated. The present system has great potential as a platform of BLM-based high throughput drug screening for ion channel proteins.

  10. Protein-induced bilayer Perturbations: Lipid ordering and hydrophobic coupling

    DEFF Research Database (Denmark)

    Petersen, Frederic Nicolas Rønne; Laursen, Ib; Bohr, Henrik;

    2009-01-01

    between the model protein gramicidin and lipid bilayers of varying thickness. The free energy of the interaction is up to −6 kJ/mol; thus not strongly favored over lipid–lipid interactions. Incorporation of gramicidin results in increased order parameters with increased protein concentration and...... hydrophobic mismatch. Our findings also show that at high protein:lipid ratios the lipids are motionally restricted but not completely immobilized. Both exchange on and off rate values for the lipid ↔ gramicidin interaction are lowest at optimal hydrophobic matching. Hydrophobic mismatch of few Å results in...

  11. Tailored sequential drug release from bilayered calcium sulfate composites

    International Nuclear Information System (INIS)

    The current standard for treating infected bony defects, such as those caused by periodontal disease, requires multiple time-consuming steps and often multiple procedures to fight the infection and recover lost tissue. Releasing an antibiotic followed by an osteogenic agent from a synthetic bone graft substitute could allow for a streamlined treatment, reducing the need for multiple surgeries and thereby shortening recovery time. Tailorable bilayered calcium sulfate (CS) bone graft substitutes were developed with the ability to sequentially release multiple therapeutic agents. Bilayered composite samples having a shell and core geometry were fabricated with varying amounts (1 or 10 wt.%) of metronidazole-loaded poly(lactic-co-glycolic acid) (PLGA) particles embedded in the shell and simvastatin directly loaded into either the shell, core, or both. Microcomputed tomography showed the overall layered geometry as well as the uniform distribution of PLGA within the shells. Dissolution studies demonstrated that the amount of PLGA particles (i.e., 1 vs. 10 wt.%) had a small but significant effect on the erosion rate (3% vs. 3.4%/d). Mechanical testing determined that introducing a layered geometry had a significant effect on the compressive strength, with an average reduction of 35%, but properties were comparable to those of mandibular trabecular bone. Sustained release of simvastatin directly loaded into CS demonstrated that changing the shell to core volume ratio dictates the duration of drug release from each layer. When loaded together in the shell or in separate layers, sequential release of metronidazole and simvastatin was achieved. By introducing a tunable, layered geometry capable of releasing multiple drugs, CS-based bone graft substitutes could be tailored in order to help streamline the multiple steps needed to regenerate tissue in infected defects. - Highlights: • Bilayered CS composites were fabricated as potential bone graft substitutes. • The shell

  12. Reconstitution of Cholesterol-Dependent Vaginolysin into Tethered Phospholipid Bilayers

    DEFF Research Database (Denmark)

    Budvytyte, Rima; Pleckaityte, M.; Zvirbliene, A.;

    2013-01-01

    Functional reconstitution of the cholesterol-dependent cytolysin vaginolysin (VLY) from Gardnerella vaginalis into artificial tethered bilayer membranes (tBLMs) has been accomplished. The reconstitution of VLY was followed in real-time by electrochemical impedance spectroscopy (EIS). Changes of the...... EIS parameters of the tBLMs upon exposure to VLY solutions were consistent with the formation of water-filled pores in the membranes. It was found that reconstitution of VLY is a strictly cholesterol-dependent, irreversible process. At a constant cholesterol concentration reconstitution of VLY...... platform for the detection of the activity of VLY and possibly other cholesterol-dependent cytolysins....

  13. A transverse Ising bilayer film with an antiferromagnetic spin configuration

    Science.gov (United States)

    Kaneyoshi, T.

    2015-10-01

    The phase diagrams and temperature dependences of magnetizations in a transverse Ising bilayer film with an antiferromagnetic spin configuration are studied by the uses of the effective-field theory (EFT) with correlations, in order to clarify whether the appearance of a compensation point is possible below the transition temperature in the system. From these investigations, we have found a lot of characteristic phenomena in these properties, when the value of an interlayer coupling takes a large value, such as the reentrant phenomenon free from the disorder-induced frustration and the novel types of magnetization curve with a compensation point.

  14. FORMULATION & EVALUATION OF BILAYER FLOATING TABLETS OF METOPROLOL TARTRATE

    OpenAIRE

    2012-01-01

    The objective of the present research was to develop a bi-layer tablet of Metoprolol tartrate using  disintegrant  starch  for the fast release layer and HPMC K grade polymers  for the sustaining layer. In vitro dissolution studies were carried out in an Indian Pharmacopoeia dissolution testing apparatus II (paddle method). The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedd...

  15. Flux Penetration in a Ferromagnetic/Superconducting Bilayer

    Science.gov (United States)

    Adamus, Z.; Cieplak, M. Z.; Abal-Oshev, A.; Kończykowski, M.; Cheng, X. M.; Zhu, L. Y.; Chien, C. L.

    2007-01-01

    An array of miniature Hall sensors is used to study the magnetic flux penetration in a ferromagnetic/superconducting bilayer consisting of Nb as a superconducting layer and Co/Pt multilayer with perpendicular magnetic anisotropy as a ferromagnetic layer, separated by an amorphous Si layer to avoid the proximity effect. It is found that the magnetic domains in the ferromagnetic layer create a large edge barrier in the superconducting layer which delays flux penetration. The smooth flux profiles observed in the absence of magnetic pinning change into terraced profiles in the presence of domains.

  16. Flux penetration in a ferromagnetic/superconducting bilayer

    International Nuclear Information System (INIS)

    An array of miniature Hall sensors is used to study the magnetic flux penetration in a ferromagnetic/superconducting bilayer consisting of Nb as a superconducting layer and Co/Pt multilayer with perpendicular magnetic anisotropy as a ferromagnetic layer, separated by an amorphous Si layer to avoid the proximity effect. It is found that the magnetic domains in the ferromagnetic layer create a large edge barrier in the superconducting layer which delays flux penetration. The smooth flux profiles observed in the absence of magnetic pinning change into terraced profiles in the presence of domains. (authors)

  17. Flux penetration in a ferromagnetic/superconducting bilayer

    Energy Technology Data Exchange (ETDEWEB)

    Adamus, Z.; Cieplak, M.Z.; Abal' Oshev, A. [Polish Acad Sci, Inst Phys, PL-02668 Warsaw, (Poland); Konczykowski, M. [CEA/DSM/DRECAM, Laboratoire des Solides Irradies, F-91191 Gif Sur Yvette, (France); Konczykowski, M. [Ecole Polytech, CNRS - UMR 7642, F-91128 Palaiseau, (France); Cheng, X.M.; Zhu, L.Y.; Chien, C.L. [Johns Hopkins Univ, Dept Phys and Astron, Baltimore, MD 21218 (United States)

    2007-07-01

    An array of miniature Hall sensors is used to study the magnetic flux penetration in a ferromagnetic/superconducting bilayer consisting of Nb as a superconducting layer and Co/Pt multilayer with perpendicular magnetic anisotropy as a ferromagnetic layer, separated by an amorphous Si layer to avoid the proximity effect. It is found that the magnetic domains in the ferromagnetic layer create a large edge barrier in the superconducting layer which delays flux penetration. The smooth flux profiles observed in the absence of magnetic pinning change into terraced profiles in the presence of domains. (authors)

  18. Giant exchange bias in MnPd/Co bilayers

    International Nuclear Information System (INIS)

    A systematic study of exchange bias in MnPd/Co bilayers has been carried out, where the dependences of exchange bias, unidirectional anisotropy constant and coercivity on the thicknesses of MnPd and Co layers were investigated. A huge unidirectional anisotropy constant, JK=2.5erg/cm2 was observed, which is in reasonable agreement with the theoretical prediction based on the model by Meiklejohn and Bean. The angular dependences of exchange bias field and coercivity have also been examined showing that both exchange bias and coercivity follow 1/cosα rule

  19. Van der Waals interaction in a boron nitride bilayer

    International Nuclear Information System (INIS)

    We have carried out quantum Monte Carlo (QMC) calculations to study the interlayer interaction in a boron nitride (BN) bilayer. The binding energy, 81 meV/2BN after finite-size corrections, was found to be larger than that obtained by density functional theory (DFT) with local density approximation, and smaller than those using van der Waals density functionals, both by considerable amounts. The QMC calculated interaction beyond the equilibrium interlayer separation was found to have a longer-range behavior than all the available DFT schemes. (paper)

  20. Optimum Maintenance Strategies for Highway Bridges

    DEFF Research Database (Denmark)

    Frangopol, Dan M.; Thoft-Christensen, Palle; Das, Parag C.;

    expected life-cycle costs or maximum life-cycle benefits. This is because many maintenance activities can be associated with significant costs, but their effects on bridge safety can be minor. In this paper, the program of an investigation on optimum maintenance strategies for different bridge types is......As bridges become older and maintenance costs become higher, transportation agencies are facing challenges related to implementation of optimal bridge management programs based on life cycle cost considerations. A reliability-based approach is necessary to find optimal solutions based on minimum...... described. The end result of this investigation will be a general reliability-based framework to be used by the UK Highways Agency in order to plan optimal strategies for the maintenance of its bridge network so as to optimize whole-life costs....

  1. Modeling walker synchronization on the Millennium Bridge

    Science.gov (United States)

    Eckhardt, Bruno; Ott, Edward; Strogatz, Steven H.; Abrams, Daniel M.; McRobie, Allan

    2007-02-01

    On its opening day the London Millennium footbridge experienced unexpected large amplitude wobbling subsequent to the migration of pedestrians onto the bridge. Modeling the stepping of the pedestrians on the bridge as phase oscillators, we obtain a model for the combined dynamics of people and the bridge that is analytically tractable. It provides predictions for the phase dynamics of individual walkers and for the critical number of people for the onset of oscillations. Numerical simulations and analytical estimates reproduce the linear relation between pedestrian force and bridge velocity as observed in experiments. They allow prediction of the amplitude of bridge motion, the rate of relaxation to the synchronized state and the magnitude of the fluctuations due to a finite number of people.

  2. Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing.

    Science.gov (United States)

    Thu, Hnin-Ei; Zulfakar, Mohd Hanif; Ng, Shiow-Fern

    2012-09-15

    The aims of this research were to develop a novel bilayer hydrocolloid film based on alginate and to investigate its potential as slow-release wound healing vehicle. The bilayer is composed of an upper layer impregnated with model drug (ibuprofen) and a drug-free lower layer, which acted as a rate-controlling membrane. The thickness uniformity, solvent loss, moisture vapour transmission rate (MVTR), hydration rate, morphology, rheology, mechanical properties, in vitro drug release and in vivo wound healing profiles were investigated. A smooth bilayer film with two homogenous distinct layers was produced. The characterisation results showed that bilayer has superior mechanical and rheological properties than the single layer films. The bilayers also showed low MVTR, slower hydration rate and lower drug flux in vitro compared to single layer inferring that bilayer may be useful for treating low suppurating wounds and suitable for slow release application on wound surfaces. The bilayers also provided a significant higher healing rate in vivo, with well-formed epidermis with faster granulation tissue formation when compared to the controls. In conclusions, a novel alginate-based bilayer hydrocolloid film was developed and results suggested that they can be exploited as slow-release wound dressings. PMID:22643226

  3. Solid-Supported Monolayers and Bilayers of Amphiphilic B-Cyclodextrins

    NARCIS (Netherlands)

    Cristiano, Antonella; Lim, Choon Woo; Rozkiewicz, Dorota I.; Reinhoudt, David N.; Ravoo, Bart Jan

    2007-01-01

    This paper describes the adsorption and spreading of B-cyclodextrin (CD) vesicles on hydrophobic and hydrophilic substrates, which involves a transition from bilayer vesicles to planar molecular monolayers or bilayers. On substrates that are patterned with self-assembled monolayers by microcontact p

  4. Effect of fatty acids on phase behavior of hydrated dipalmitoylphosphatidylcholine bilayer: saturated versus unsaturated fatty acids.

    Science.gov (United States)

    Inoue, T; Yanagihara, S; Misono, Y; Suzuki, M

    2001-02-01

    The effect of some fatty acids on the phase behavior of hydrated dipalmitoylphosphatidylcholine (DPPC) bilayer was investigated with special interest in possible difference between saturated and unsaturated fatty acids. The phase behavior of hydrated DPPC bilayer was followed by a differential scanning calorimetry and a Fourier transform infrared spectroscopy. The addition of palmitic acid (PA) increased the bilayer phase transition temperature with the increase of the PA content in the mixture. In addition, DPPC molecules in gel phase bilayer became more rigid in the presence of PA compared with those in the absence of PA. This effect of PA on the phase behavior of hydrated DPPC bilayer is common to other saturated fatty acids, stearic acid, myristic acid, and also to unsaturated fatty acid with trans double bond, elaidic acid. Contrary to these fatty acids, oleic acid (OA), the unsaturated fatty acid with cis double bond in the acyl chain, exhibited quite different behavior. The effect of OA on the bilayer phase transition temperature was rather small, although a slight decrease in the temperature was appreciable. Furthermore, the IR spectral results demonstrated that the perturbing effect of OA on the gel phase bilayer of DPPC was quite small. These results mean that OA does not disturb the hydrated DPPC bilayer significantly. PMID:11269932

  5. Ca2+-induced isotropic motion and phosphatidylcholine flip-flop in phosphatidylcholine-cardiolipin bilayers

    OpenAIRE

    Gerritsen, W.J.; de Kruijff, B.; Verkleij, A.J.; Gier, J.; Van Deenen, L. L. M.

    1980-01-01

    Ca2+ induces a structural change in phosphatidylcholine-cardiolipin bilayers, which is visualised by freeze-fracturing as lipidic particles associated with the bilayer and is detected by 31P-NMR as isotropic motion of the phospholipids. In this structure a rapid transbilayer movement of phosphatidylcholine and a highly increased permeability towards Mn2+ are observed.

  6. Sign reversal of drag in bilayer systems with in-plane periodic potential modulation

    DEFF Research Database (Denmark)

    Alkauskas, A.; Flensberg, Karsten; Hu, Ben Yu-Kuang; Jauho, Antti-Pekka

    2002-01-01

    We develop a theory for describing frictional drag in bilayer systems with in-plane periodic potential modulations, and use it to investigate the drag between bilayer systems in which one of the layers is modulated in one direction. At low temperatures, as the density of carriers in the modulated...

  7. High Resistivity Lipid Bilayers Assembled on Polyelectrolyte Multilayer Cushions: An Impedance Study.

    Science.gov (United States)

    Diamanti, Eleftheria; Gregurec, Danijela; Rodríguez-Presa, María José; Gervasi, Claudio A; Azzaroni, Omar; Moya, Sergio E

    2016-06-28

    Supported membranes on top of polymer cushions are interesting models of biomembranes as cell membranes are supported on a polymer network of proteins and sugars. In this work lipid vesicles formed by a mixture of 30% 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 70% 1,2-dioleoyl-sn-glycero-3-phospho-l-serine (DOPS) are assembled on top of a polyelectrolyte multilayer (PEM) cushion of poly(allylamine hydrochloride) (PAH) and poly(styrene sodium sulfonate) (PSS). The assembly results in the formation of a bilayer on top of the PEM as proven by means of the quartz crystal microbalance with dissipation technique (QCM-D) and by cryo-transmission electron microscopy (cryo-TEM). The electrical properties of the bilayer are studied by electrochemical impedance spectroscopy (EIS). The bilayer supported on the PEMs shows a high resistance, on the order of 10(7) Ω cm(2), which is indicative of a continuous, dense bilayer. Such resistance is comparable with the resistance of black lipid membranes. This is the first time that such values are obtained for lipid bilayers supported on PEMs. The assembly of polyelectrolytes on top of a lipid bilayer decreases the resistance of the bilayer up to 2 orders of magnitude. The assembly of the polyelectrolytes on the lipids induces defects or pores in the bilayer which in turn prompts a decrease in the measured resistance. PMID:27267089

  8. Lipid Bilayer – mediated Regulation of Ion Channel Function by Amphiphilic Drugs

    DEFF Research Database (Denmark)

    Lundbæk, Jens August

    2008-01-01

    that are transforming it into a subject of quantitative science. It is described how the hydrophobic interactions between a membrane protein and the host lipid bilayer provide the basis for a mechanism, whereby protein function is regulated by the bilayer physical properties. The use of gramicidin...

  9. Molecular dynamics simulations and free energy profile of Paracetamol in DPPC and DMPC lipid bilayers

    Indian Academy of Sciences (India)

    Yousef Nademi; Sepideh Amjad Iranagh; Abbas Yousefpour; Seyedeh Zahra Mousavi; Hamid Modarress

    2014-05-01

    Molecular dynamics (MD) simulations and biased MD simulation were carried out for the neutral form of Paracetamol inserted in fully hydrated dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylcholine (DMPC) lipid bilayers. For comparison, fully hydrated DMPC and DPPC lipid bilayers were also simulated separately without Paracetamol. The simulation time for each system was 50 ns. At two concentrations of Paracetamol, various properties of the lipid bilayer such as area per lipid, order parameter, diffusion coefficient, radial distribution function, electrostatic potential, mass density and hydrogen bonds have been calculated. Also, the convergence in time of the free energy profile of the Paracetamol along a DPPC bilayer normal was calculated by umbrella sampling method. From the obtained results, it can be concluded that neutral form of Paracetamol shows a generally similar behaviour in DPPC and DMPC lipid bilayers. It was shown that the addition of Paracetamol causes a decrease in tail order parameter of both DPPC and DMPC lipid bilayers and the tail of Paracetamol adopts an inward orientation in the lipid bilayers. Also from the free energy profile, the high penetration barrier in the bilayer centre was determined.

  10. Edge State Transport of Separately Contacted Bilayer Systems in the Fractional Quantum Hall Regime

    OpenAIRE

    Yoshioka, Daijiro; Nomura, Kentaro

    1999-01-01

    Hall and diagonal resistances of bilayer fractional quantum Hall systems are discussed theoretically. The bilayers have electrodes attached separately to each layer. They are assumed to be coupled weakly by interlayer tunneling, while the interlayer Coulomb interaction is negligibly small. It is shown that source-drain voltage dependence of the resistances reflects the Luttinger liquid parameter of the edge state.

  11. Real-Time Structural Investigation of a Lipid Bilayer during Its Interaction with Melittin Using Sum Frequency Generation Vibrational Spectroscopy

    OpenAIRE

    Chen, Xiaoyun; Wang, Jie; Kristalyn, Cornelius B.; Chen, Zhan

    2007-01-01

    Interactions between membrane bilayers and peptides/proteins are ubiquitous throughout a cell. To determine the structure of membrane bilayers and the associated peptides/proteins, model systems such as supported lipid bilayers are often used. It has been difficult to directly investigate the interactions between a single membrane bilayer and peptides/proteins without exogenous labeling. In this work we demonstrate that sum frequency generation vibrational spectroscopy can be employed to stud...

  12. Hydration-optimized oriented phospholipid bilayer samples for solid-state NMR structural studies of membrane proteins

    OpenAIRE

    Marassi, Francesca M.; Crowell, Kevin J.

    2003-01-01

    The preparation of oriented, hydration-optimized lipid bilayer samples, for NMR structure determination of membrane proteins, is described. The samples consist of planar phospholipid bilayers, containing membrane proteins, that are oriented on single pairs of glass slides, and are placed in the coil of the NMR probe with the bilayer plane perpendicular to the direction of the magnetic field. Lipid bilayers provide a medium that closely resembles the biological membrane, and sample orientation...

  13. Building bridges … and accelerators

    CERN Multimedia

    2009-01-01

    Lyn Evans, the LHC project leader, was awarded an honorary doctorate from the University of Geneva (UNIGE) to celebrate his role not just in building accelerators, but also in building bridges between nations. He was one of four notables honoured at the event on Friday 5 June, coinciding with the University’s 450th Anniversary. Lyn Evans arriving at the ceremony with Archbishop Desmond Tutu. "It was a big surprise when I found out I’d been nominated," recounts Evans, "but it was an even bigger surprise to find out with whom I’d been nominated". At the ceremony Evans was awarded the honorary doctorate along with three others: Archbishop Desmond Tutu, who was acclaimed for his fight against apartheid in South Africa, Mary Robinson, first woman president of Ireland and former United Nations’ high commissioner of human rights, and Pascal Lamy, Director-General of the World Trade Organization. The award ceremony, known as the �...

  14. Membrane bridging and hemifusion by denaturated Munc18.

    Directory of Open Access Journals (Sweden)

    Yi Xu

    Full Text Available Neuronal Munc18-1 and members of the Sec1/Munc18 (SM protein family play a critical function(s in intracellular membrane fusion together with SNARE proteins, but the mechanism of action of SM proteins remains highly enigmatic. During experiments designed to address this question employing a 7-nitrobenz-2-oxa-1,3-diazole (NBD fluorescence de-quenching assay that is widely used to study lipid mixing between reconstituted proteoliposomes, we observed that Munc18-1 from squid (sMunc18-1 was able to increase the apparent NBD fluorescence emission intensity even in the absence of SNARE proteins. Fluorescence emission scans and dynamic light scattering experiments show that this phenomenon arises at least in part from increased light scattering due to sMunc18-1-induced liposome clustering. Nuclear magnetic resonance and circular dichroism data suggest that, although native sMunc18-1 does not bind significantly to lipids, sMunc18-1 denaturation at 37 °C leads to insertion into membranes. The liposome clustering activity of sMunc18-1 can thus be attributed to its ability to bridge two membranes upon (perhaps partial denaturation; correspondingly, this activity is hindered by addition of glycerol. Cryo-electron microscopy shows that liposome clusters induced by sMunc18-1 include extended interfaces where the bilayers of two liposomes come into very close proximity, and clear hemifusion diaphragms. Although the physiological relevance of our results is uncertain, they emphasize the necessity of complementing fluorescence de-quenching assays with alternative experiments in studies of membrane fusion, as well as the importance of considering the potential effects of protein denaturation. In addition, our data suggest a novel mechanism of membrane hemifusion induced by amphipathic macromolecules that does not involve formation of a stalk intermediate.

  15. Modified Geometry of Transition Slabs for Integral Bridges

    OpenAIRE

    Dreier, Damien

    2010-01-01

    Over the past decades, an increasing number of integral bridges have been built. This type of bridge offers various advantages in comparison with standard bridges equipped with expansion joints and bearings. In particular, integral bridges require less maintenance since they require less mechanical elements. Transition slabs, which are used in integral bridges, are directly connected to the bridge deck and therefore they are subjected to large displacements caused by creep, shrinkage and temp...

  16. Finite element of multilayer surfacing systems on orthotropic steel bridges

    OpenAIRE

    Li, J.; Liu, X.; Scarpas, A.; Tzimiris, G.

    2013-01-01

    Light weight orthotropic steel bridge decks have been widely utilized for bridges in seismic zones, movable bridges and long span bridges. In the last three decades, severe problems were reported in relation to asphaltic surfacing materials on orthotropic steel deck bridges. Earlier investigations have shown that the bonding strength of membrane layers to the surrounding materials has a strong influence on the structural response of orthotropic steel bridge decks. The most important requireme...

  17. Regulation of membrane protein function by lipid bilayer elasticity-a single molecule technology to measure the bilayer properties experienced by an embedded protein

    Energy Technology Data Exchange (ETDEWEB)

    Lundbaek, Jens August [Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021 (United States)

    2006-07-19

    Membrane protein function is generally regulated by the molecular composition of the host lipid bilayer. The underlying mechanisms have long remained enigmatic. Some cases involve specific molecular interactions, but very often lipids and other amphiphiles, which are adsorbed to lipid bilayers, regulate a number of structurally unrelated proteins in an apparently non-specific manner. It is well known that changes in the physical properties of a lipid bilayer (e.g., thickness or monolayer spontaneous curvature) can affect the function of an embedded protein. However, the role of such changes, in the general regulation of membrane protein function, is unclear. This is to a large extent due to lack of a generally accepted framework in which to understand the many observations. The present review summarizes studies which have demonstrated that the hydrophobic interactions between a membrane protein and the host lipid bilayer provide an energetic coupling, whereby protein function can be regulated by the bilayer elasticity. The feasibility of this 'hydrophobic coupling mechanism' has been demonstrated using the gramicidin channel, a model membrane protein, in planar lipid bilayers. Using voltage-dependent sodium channels, N-type calcium channels and GABA{sub A} receptors, it has been shown that membrane protein function in living cells can be regulated by amphiphile induced changes in bilayer elasticity. Using the gramicidin channel as a molecular force transducer, a nanotechnology to measure the elastic properties experienced by an embedded protein has been developed. A theoretical and technological framework, to study the regulation of membrane protein function by lipid bilayer elasticity, has been established.

  18. Interaction of Ionic Liquids with a Lipid Bilayer: A Biophysical Study of Ionic Liquid Cytotoxicity.

    Science.gov (United States)

    Jing, Benxin; Lan, Nan; Qiu, Jie; Zhu, Yingxi

    2016-03-17

    Ionic liquids (ILs) have been widely considered and used as "green solvents" for more than two decades. However, their ecotoxicity results have contradicted this view, as ILs, particularly hydrophobic ones, are reported to exhibit high toxicity. Yet the origin of their toxicology remains unclear. In this work, we have investigated the interaction of amphiphilic ILs with a lipid bilayer as a model cell membrane to understand their cytotoxicity at a molecular level. By employing fluorescence imaging and light and X-ray scattering techniques, we have found that amphiphilic ILs could disrupt the lipid bilayer by IL insertion, end-capping the hydrophobic edge of the lipid bilayer, and eventually disintegrating the lipid bilayer at high IL concentration. The insertion of ILs to cause the swelling of the lipid bilayer shows strong dependence on the hydrophobicity of IL cationic alky chain and anions and is strongly correlated with the reported IL cytotoxicity. PMID:26910537

  19. A simple method to tune graphene growth between monolayer and bilayer

    Directory of Open Access Journals (Sweden)

    Xiaozhi Xu

    2016-02-01

    Full Text Available Selective growth of either monolayer or bilayer graphene is of great importance. We developed a method to readily tune large area graphene growth from complete monolayer to complete bilayer. In an ambient pressure chemical vapor deposition process, we used the sample temperature at which to start the H2 flow as the control parameter and realized the change from monolayer to bilayer growth of graphene on Cu foil. When the H2 starting temperature was above 700°C, continuous monolayer graphene films were obtained. When the H2 starting temperature was below 350°C, continuous bilayer films were obtained. Detailed characterization of the samples treated under various conditions revealed that heating without the H2 flow caused Cu oxidation. The more the Cu substrate oxidized, the less graphene bilayer could form.

  20. A simple method to tune graphene growth between monolayer and bilayer

    Science.gov (United States)

    Xu, Xiaozhi; Lin, Chenfang; Fu, Rui; Wang, Shuo; Pan, Rui; Chen, Guangshi; Shen, Qixin; Liu, Can; Guo, Xia; Wang, Yiquan; Zhao, Ruguang; Liu, Kaihui; Luo, Zhengtang; Hu, Zonghai; Li, Hongyun

    2016-02-01

    Selective growth of either monolayer or bilayer graphene is of great importance. We developed a method to readily tune large area graphene growth from complete monolayer to complete bilayer. In an ambient pressure chemical vapor deposition process, we used the sample temperature at which to start the H2 flow as the control parameter and realized the change from monolayer to bilayer growth of graphene on Cu foil. When the H2 starting temperature was above 700°C, continuous monolayer graphene films were obtained. When the H2 starting temperature was below 350°C, continuous bilayer films were obtained. Detailed characterization of the samples treated under various conditions revealed that heating without the H2 flow caused Cu oxidation. The more the Cu substrate oxidized, the less graphene bilayer could form.

  1. Filament networks attached to membranes: cytoskeletal pressure and local bilayer deformation

    Energy Technology Data Exchange (ETDEWEB)

    Auth, Thorsten [Department of Materials and Interfaces, Weizmann Institute of Science, PO Box 26, Rehovot 76100 (Israel); Safran, S A [Department of Materials and Interfaces, Weizmann Institute of Science, PO Box 26, Rehovot 76100 (Israel); Gov, Nir S [Department of Chemical Physics, Weizmann Institute of Science, PO Box 26, Rehovot 76100 (Israel)

    2007-11-15

    Several cell types, among them red blood cells, have a cortical, two-dimensional (2D) network of filaments sparsely attached to their lipid bilayer. In many mammalian cells, this 2D polymer network is connected to an underlying 3D, more rigid cytoskeleton. In this paper, we consider the pressure exerted by the thermally fluctuating, cortical network of filaments on the bilayer and predict the bilayer deformations that are induced by this pressure. We treat the filaments as flexible polymers and calculate the pressure that a network of such linear chains exerts on the bilayer; we then minimize the bilayer shape in order to predict the resulting local deformations. We compare our predictions with membrane deformations observed in electron micrographs of red blood cells. The polymer pressure along with the resulting membrane deformation can lead to compartmentalization, regulate in-plane diffusion and may influence protein sorting as well as transmit signals to the polymerization of the underlying 3D cytoskeleton.

  2. CONTEMPORARY APPROACHES FOR BI-LAYER TECHNOLOGY OF DRUGS THROUGH ORAL ROUTE: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Rishikesh*, M. A. Bhuiyan, S. M. Ashraful Islam, I. Dewan, Md. A. Islam and Md. S.- Ul H. Miah

    2013-04-01

    Full Text Available ABSTRACT: Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction. This review indicates the different aspects of drug release mechanism, different strategies of drug release, various techniques for bilayer tablet, and the influence of different process and formulation parameters must be considered during the development of bilayer tablet. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose.

  3. Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

    Science.gov (United States)

    Cox, Charles D.; Bae, Chilman; Ziegler, Lynn; Hartley, Silas; Nikolova-Krstevski, Vesna; Rohde, Paul R.; Ng, Chai-Ann; Sachs, Frederick; Gottlieb, Philip A.; Martinac, Boris

    2016-01-01

    Mechanosensitive ion channels are force-transducing enzymes that couple mechanical stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is challenging because the stimulus seen by the channel reflects forces shared between the membrane, cytoskeleton and extracellular matrix. Here we examine whether the mechanosensitive channel PIEZO1 is activated by force-transmission through the bilayer. To achieve this, we generate HEK293 cell membrane blebs largely free of cytoskeleton. Using the bacterial channel MscL, we calibrate the bilayer tension demonstrating that activation of MscL in blebs is identical to that in reconstituted bilayers. Utilizing a novel PIEZO1-GFP fusion, we then show PIEZO1 is activated by bilayer tension in bleb membranes, gating at lower pressures indicative of removal of the cortical cytoskeleton and the mechanoprotection it provides. Thus, PIEZO1 channels must sense force directly transmitted through the bilayer.

  4. Growth and characterization of the ZnO/ZnS bilayer obtained by chemical spray pyrolysis

    International Nuclear Information System (INIS)

    ZnO/ZnS bilayer antireflection coatings have been prepared by spray pyrolysis using aqueous solutions of zinc acetate and thiourea or zinc chloride and thiourea. The structure, surface morphology, chemical composition and optical transmittance of the bilayer have been examined as a function of the composition of the initial solution. X-ray photoelectron spectroscopy analysis and Ar ion-beam sputter etching was carried out to obtain a depth profile of bilayer. Neither carbon nor other by-products, which could alter the optical transmittance of the bilayer were found in either the interface or bulk. The differences between the bilayers arise from the annealing of the ZnS underlayer, as well as the precursor used to prepare it.

  5. Point contact Andreev reflection spectroscopy on ferromagnet/superconductor bilayers

    International Nuclear Information System (INIS)

    Highlights: • We performed PCAR spectroscopy on ferromagnet–superconductor bilayer (N/F/S). • Low temperature conductance spectra show very high zero bias peak. • Scattering theory is used to model N/F/S point contact configuration. • Fittings allow precise estimation of spin polarization and thickness for F-layer. - Abstract: We performed point contact spectroscopy experiment by pushing gold tip on the ferromagnetic side of Nb/Pd0.84Ni0.16 bilayers. Several contacts have been measured at temperature 4.2 K evidencing a wide variety of features (zero bias peak, conductance dips, etc.) appearing in the differential conductance spectra at energies up to Nb energy gap. A theoretical model has been developed within the scattering theory for ferromagnetic/superconductor heterostructures to fit experimental data. All different features can be consistently explained in our model by taking into account the spin polarization as well as the thickness of the ferromagnetic layer. We also show that we can give very precise estimation of such ferromagnetic characteristics

  6. Melittin-induced cholesterol reorganization in lipid bilayer membranes.

    Science.gov (United States)

    Qian, Shuo; Heller, William T

    2015-10-01

    The peptide melittin, a 26 amino acid, cationic peptide from honey bee (Apis mellifera) venom, disrupts lipid bilayer membranes in a concentration-dependent manner. Rather than interacting with a specific receptor, the peptide interacts directly with the lipid matrix of the membrane in a manner dependent on the lipid composition. Here, a small-angle neutron scattering study of the interaction of melittin with lipid bilayers made of mixtures of dimyristoylphosphatidylcholine (DMPC) and cholesterol (Chol) is presented. Through the use of deuterium-labeled DMPC, changes in the distribution of the lipid and cholesterol in unilamellar vesicles were observed for peptide concentrations below those that cause pores to form. In addition to disrupting the in-plane organization of Chol, melittin produces vesicles having inner and outer leaflet compositions that depend on the lipid-Chol molar ratio and on the peptide concentration. The changes seen at high cholesterol and low peptide concentration are similar to those produced by alamethicin (Qian, S. et al., J. Phys. Chem. B 2014, 118, 11200-11208), which points to an underlying physical mechanism driving the redistribution of Chol, but melittin displays an additional effect not seen with alamethicin. A model for how the peptide drives the redistribution of Chol is proposed. The results suggest that redistribution of the lipids in a target cell membrane by membrane active peptides takes places as a prelude to the lysis of the cell. PMID:26074009

  7. Conductance and shot noise in strained bilayer graphene.

    Science.gov (United States)

    Pearce, Alexander J; Cavaliere, Fabio; Mariani, Eros

    2013-09-18

    We explore the effect of trigonal warping and of elastic deformations on the electronic spectrum of bilayer graphene devices, on their ballistic conductance as well as on the shot noise. Uniaxial strain distorts the lattice creating a uniform fictitious gauge field in the electronic Dirac Hamiltonian which ultimately causes a dramatic reconstruction in the trigonally warped electronic spectrum, inducing topological transitions in the Fermi surface. In this paper we present results of ballistic transport in bilayer graphene in the absence and presence of strain, with particular focus on noise and the Fano factor F. The inclusion of trigonal warping preserves the pseudo-diffusive value of F = 1/3 at the Dirac point, as calculated in the absence of trigonal warping terms. However, the range of energies which show pseudo-diffusive transport increases by orders of magnitude compared to the results stemming out of a parabolic spectrum and the applied strain acts to increase this energy range further. PMID:23963478

  8. Vibration analysis of bi-layered FGM cylindrical shells

    Energy Technology Data Exchange (ETDEWEB)

    Arshad, Shahid Hussain; Sultana, Nazra; Iqbal, Zafar [University of Sargodha, Department of Mathematics, Sargodha, Punjab (Pakistan); Naeem, Muhammad Nawaz [G C University Faisalabad, Department of Mathematics, Faisalabad, Punjab (Pakistan); Shah, Abdul Ghafar [The Islamia University of Bahawalpur, Department of Mathematics, Bahawalpur, Punjab (Pakistan)

    2011-03-15

    In the present study, a vibration frequency analysis of a bi-layered cylindrical shell composed of two independent functionally graded layers is presented. The thickness of the shell layers is assumed to be equal and constant. Material properties of the constituents of bi-layered functionally graded cylindrical shell are assumed to vary smoothly and continuously through the thickness of the layers of the shell and are controlled by volume fraction power law distribution. The expressions for strain-displacement and curvature-displacement relationships are utilized from Love's first approximation linear thin shell theory. The versatile Rayleigh-Ritz approach is employed to formulate the frequency equations in the form of eigenvalue problem. Influence of material distribution in the two functionally graded layers of the cylindrical shells is investigated on shell natural frequencies for various shell parameters with simply supported end conditions. To check the validity, accuracy and efficiency of the present methodology, results obtained are compared with those available in the literature. (orig.)

  9. Unidirectional spin Hall magnetoresistance in ferromagnet/normal metal bilayers

    Science.gov (United States)

    Avci, Can Onur; Garello, Kevin; Ghosh, Abhijit; Gabureac, Mihai; Alvarado, Santos F.; Gambardella, Pietro

    2015-07-01

    Magnetoresistive effects are usually invariant on inversion of the magnetization direction. In non-centrosymmetric conductors, however, nonlinear resistive terms can give rise to a current dependence that is quadratic in the applied voltage and linear in the magnetization. Here we demonstrate that such conditions are realized in simple bilayer metal films where the spin-orbit interaction and spin-dependent scattering couple the current-induced spin accumulation to the electrical conductivity. We show that the longitudinal resistance of Ta|Co and Pt|Co bilayers changes when reversing the polarity of the current or the sign of the magnetization. This unidirectional magnetoresistance scales linearly with current density and has opposite sign in Ta and Pt, which we associate with the modification of the interface scattering potential induced by the spin Hall effect in these materials. Our results suggest a route to control the resistance and detect magnetization switching in spintronic devices using a two-terminal geometry, which applies also to heterostructures including topological insulators.

  10. Multiscale modeling of droplet interface bilayer membrane networks.

    Science.gov (United States)

    Freeman, Eric C; Farimani, Amir B; Aluru, Narayana R; Philen, Michael K

    2015-11-01

    Droplet interface bilayer (DIB) networks are considered for the development of stimuli-responsive membrane-based materials inspired by cellular mechanics. These DIB networks are often modeled as combinations of electrical circuit analogues, creating complex networks of capacitors and resistors that mimic the biomolecular structures. These empirical models are capable of replicating data from electrophysiology experiments, but these models do not accurately capture the underlying physical phenomena and consequently do not allow for simulations of material functionalities beyond the voltage-clamp or current-clamp conditions. The work presented here provides a more robust description of DIB network behavior through the development of a hierarchical multiscale model, recognizing that the macroscopic network properties are functions of their underlying molecular structure. The result of this research is a modeling methodology based on controlled exchanges across the interfaces of neighboring droplets. This methodology is validated against experimental data, and an extension case is provided to demonstrate possible future applications of droplet interface bilayer networks. PMID:26594262

  11. Graphene quantum dots: localized states, edges and bilayer systems

    Science.gov (United States)

    Ensslin, Klaus

    2014-03-01

    Graphene quantum dots show Coulomb blockade, excited states and their orbital and spin properties have been investigated in high magnetic fields. Most quantum dots fabricated to date are fabricated with electron beam lithography and dry etching which generally leads to uncontrolled and probably rough edges. We demonstrate that devices with reduced bulk disorder fabricated on BN substrates display similar localized states as those fabricated on the more standard SiO2 substrates. For a highly symmetric quantum dot with short tunnel barriers the experimentally detected transport features can be explained by three localized states, 1 in the dot and 2 in the constrictions. A way to overcome edge roughness and the localized states related to this are bilayer devices where a band gap can be induced by suitable top and back gate voltages. By placing bilayer graphene between two BN layers high electronic quality can be achieved as documented by the observation of broken symmetry states in the quantum Hall regime. We discuss how this method can be exploited to achieve smoother and better tunable graphene quantum devices. This work was done in collaboration with D. Bischoff, P. Simonet, A. Varlet, Y. Tian, and T. Ihn.

  12. Surface and interfacial creases in a bilayer tubular soft tissue

    Science.gov (United States)

    Razavi, Mir Jalil; Pidaparti, Ramana; Wang, Xianqiao

    2016-08-01

    Surface and interfacial creases induced by biological growth are common types of instability in soft biological tissues. This study focuses on the criteria for the onset of surface and interfacial creases as well as their morphological evolution in a growing bilayer soft tube within a confined environment. Critical growth ratios for triggering surface and interfacial creases are investigated both analytically and numerically. Analytical interpretations provide preliminary insights into critical stretches and growth ratios for the onset of instability and formation of both surface and interfacial creases. However, the analytical approach cannot predict the evolution pattern of the model after instability; therefore nonlinear finite element simulations are carried out to replicate the poststability morphological patterns of the structure. Analytical and computational simulation results demonstrate that the initial geometry, growth ratio, and shear modulus ratio of the layers are the most influential factors to control surface and interfacial crease formation in this soft tubular bilayer. The competition between the stretch ratios in the free and interfacial surfaces is one of the key driving factors to determine the location of the first crease initiation. These findings may provide some fundamental understanding in the growth modeling of tubular biological tissues such as esophagi and airways as well as offering useful clues into normal and pathological functions of these tissues.

  13. Dynamic and mechanical properties of supported lipid bilayers

    Science.gov (United States)

    Wu, Hsing-Lun; Tsao, Heng-Kwong; Sheng, Yu-Jane

    2016-04-01

    Supported lipid bilayers (SLBs) offer an excellent model system for investigating the physico-chemical properties of the cell membrane. In this work, dynamic and mechanical properties of SLBs are explored by dissipative particle dynamics simulations for lipids with different architectures (chain length, kink, and asymmetry associated with lipid tails). It is found that the lateral diffusivity (Dx) and flip-flop rate (FF) grow with increasing temperature in both gel and liquid phases and can be described by an Arrhenius-like expression. Three regimes can be clearly identified for symmetric and asymmetric saturated lipids but only two regimes are observed for kinked lipids. Both Dx and FF grow with decreasing tail length and increasing number of kinks. The stretching (KA) and apparent bending (KB) moduli exhibit concave upward curves with temperature and the minima are attained at Tm. In general, the minima of KA and KB decrease with the chain length and increase with number of kinks. The typical relation among the bending modulus, area stretching modulus, and bilayer thickness is still followed, KB = βKAh2 and β is much smaller in the gel phase. The dynamic and mechanical properties of lipids with asymmetric tails are found to situate between their symmetric counterparts.

  14. Point contact Andreev reflection spectroscopy on ferromagnet/superconductor bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Giubileo, F., E-mail: filippo.giubileo@spin.cnr.it [CNR-SPIN Salerno, c/o Dipartimento di Fisica, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Romeo, F.; Citro, R. [Dipartimento di Fisica “E.R. Caianiello”, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); CNR-SPIN Salerno, c/o Dipartimento di Fisica, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Di Bartolomeo, A. [Dipartimento di Fisica “E.R. Caianiello”, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Attanasio, C. [Dipartimento di Fisica “E.R. Caianiello”, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); CNR-SPIN Salerno, c/o Dipartimento di Fisica, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Cirillo, C. [CNR-SPIN Salerno, c/o Dipartimento di Fisica, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Dipartimento di Fisica “E.R. Caianiello”, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy); Polcari, A. [Dipartimento di Scienze e Tecnologie, Università del Sannio, 82100 Benevento (Italy); Romano, P. [Dipartimento di Scienze e Tecnologie, Università del Sannio, 82100 Benevento (Italy); CNR-SPIN Salerno, c/o Dipartimento di Fisica, Università degli Studi di Salerno, 84084 Fisciano, SA (Italy)

    2014-08-15

    Highlights: • We performed PCAR spectroscopy on ferromagnet–superconductor bilayer (N/F/S). • Low temperature conductance spectra show very high zero bias peak. • Scattering theory is used to model N/F/S point contact configuration. • Fittings allow precise estimation of spin polarization and thickness for F-layer. - Abstract: We performed point contact spectroscopy experiment by pushing gold tip on the ferromagnetic side of Nb/Pd{sub 0.84}Ni{sub 0.16} bilayers. Several contacts have been measured at temperature 4.2 K evidencing a wide variety of features (zero bias peak, conductance dips, etc.) appearing in the differential conductance spectra at energies up to Nb energy gap. A theoretical model has been developed within the scattering theory for ferromagnetic/superconductor heterostructures to fit experimental data. All different features can be consistently explained in our model by taking into account the spin polarization as well as the thickness of the ferromagnetic layer. We also show that we can give very precise estimation of such ferromagnetic characteristics.

  15. Protein-induced bilayer perturbations: Lipid ordering and hydrophobic coupling

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Frederic N.R.; Laursen, Ib; Bohr, Henrik [Quantum Protein Center, Department of Physics, Technical University of Denmark, DK-2800 Kgs. Lyngby (Denmark); Nielsen, Claus Helix, E-mail: claus.nielsen@fysik.dtu.dk [Quantum Protein Center, Department of Physics, Technical University of Denmark, DK-2800 Kgs. Lyngby (Denmark); Aquaporin A/S, Diplomvej 377, DK-2800 Kgs. Lyngby (Denmark)

    2009-10-02

    The host lipid bilayer is increasingly being recognized as an important non-specific regulator of membrane protein function. Despite considerable progress the interplay between hydrophobic coupling and lipid ordering is still elusive. We use electron spin resonance (ESR) to study the interaction between the model protein gramicidin and lipid bilayers of varying thickness. The free energy of the interaction is up to -6 kJ/mol; thus not strongly favored over lipid-lipid interactions. Incorporation of gramicidin results in increased order parameters with increased protein concentration and hydrophobic mismatch. Our findings also show that at high protein:lipid ratios the lipids are motionally restricted but not completely immobilized. Both exchange on and off rate values for the lipid {r_reversible} gramicidin interaction are lowest at optimal hydrophobic matching. Hydrophobic mismatch of few A results in up to 10-fold increased exchange rates as compared to the 'optimal' match situation pointing to the regulatory role of hydrophobic coupling in lipid-protein interactions.

  16. Embedding Ba Monolayers and Bilayers in Boron Carbide Nanowires

    Science.gov (United States)

    Yu, Zhiyang; Luo, Jian; Shi, Baiou; Zhao, Jiong; Harmer, Martin P.; Zhu, Jing

    2015-11-01

    Aberration corrected high angle annular dark field scanning transmission electron microscopy (HAADF-STEM) was employed to study the distribution of barium atoms on the surfaces and in the interiors of boron carbide based nanowires. Barium based dopants, which were used to control the crystal growth, adsorbed to the surfaces of the boron-rich crystals in the form of nanometer-thick surficial films (a type of surface complexion). During the crystal growth, these dopant-based surface complexions became embedded inside the single crystalline segments of fivefold boron-rich nanowires collectively, where they were converted to more ordered monolayer and bilayer modified complexions. Another form of bilayer complexion stabilized at stacking faults has also been identified. Numerous previous works suggested that dopants/impurities tended to segregate at the stacking faults or twinned boundaries. In contrast, our study revealed the previously-unrecognized possibility of incorporating dopants and impurities inside an otherwise perfect crystal without the association to any twin boundary or stacking fault. Moreover, we revealed the amount of barium dopants incorporated was non-equilibrium and far beyond the bulk solubility, which might lead to unique properties.

  17. Fibonacci anyons from Abelian bilayer quantum Hall states.

    Science.gov (United States)

    Vaezi, Abolhassan; Barkeshli, Maissam

    2014-12-01

    The possibility of realizing non-Abelian statistics and utilizing it for topological quantum computation (TQC) has generated widespread interest. However, the non-Abelian statistics that can be realized in most accessible proposals is not powerful enough for universal TQC. In this Letter, we consider a simple bilayer fractional quantum Hall system with the 1/3 Laughlin state in each layer. We show that interlayer tunneling can drive a transition to an exotic non-Abelian state that contains the famous "Fibonacci" anyon, whose non-Abelian statistics is powerful enough for universal TQC. Our analysis rests on startling agreements from a variety of distinct methods, including thin torus limits, effective field theories, and coupled wire constructions. We provide evidence that the transition can be continuous, at which point the charge gap remains open while the neutral gap closes. This raises the question of whether these exotic phases may have already been realized at ν=2/3 in bilayers, as past experiments may not have definitively ruled them out. PMID:25526149

  18. Vortex confinement by magnetic domains in superconductor-ferromagnet bilayers

    Science.gov (United States)

    Cieplak, Marta Z.; Adamus, Z.; Konczykowski, M.; Zhu, L. Y.; Chien, C. L.; Cheng, X. M.

    2013-03-01

    We use a line of miniature Hall sensors to study the effect of magnetic-domain-induced vortex confinement on the flux dynamics in a superconductor/ferromagnet bilayer. A single tunable bilayer is built of a ferromagnetic Co/Pt multilayer with perpendicular magnetic anisotropy and a superconducting Nb layer, with the insulating layer in between to avoid proximity effect. The magnetic domain patterns of various geometries are reversibly predefined in the Co/Pt multilayer using the appropriate magnetization procedure. The magnetic domain geometry strongly affects vortex dynamics, leading to geometry-dependent trapping of vortices at the sample edge, nonuniform flux penetration, and strongly nonuniform critical current density. With the decreasing temperature the magnetic pinning increases but this increase is substantially weaker than that of the intrinsic pinning. The analysis of the initial flux penetration suggests that vortices may form various vortex structures, including disordered Abrikosov lattice or single and double vortex chains, in which minimal vortex-vortex distance is comparable to the magnetic penetration depth. Supported by Polish NCS grant 2011/01/B/ST3/00462, by the French-Polish Program PICS 2012, by EU grant POIG.01.01.02-00-108/09, and by NSF grants DMR05-20491 and DMR-1053854.

  19. Bi-layer functionally gradient thick film semiconducting methane sensors

    Indian Academy of Sciences (India)

    A Banerjee; A K Haldar; J Mondal; A Sen; H S Maiti

    2002-11-01

    Gas sensors based on metal oxide semiconductors like tin dioxide are widely used for the detection of toxic and combustible gases like carbon monoxide, methane and LPG. One of the problems of such sensors is their lack of sensitivity, which to some extent, can be circumvented by using different catalysts. However, highly reactive volatile organic compounds (VOC) coming from different industrial and domestic products (e.g. paints, lacquers, varnishes etc) can play havoc on such sensors and can give rise to false alarms. Any attempt to adsorb such VOCs (e.g. by using activated charcoal) results in sorption of the detecting gases (e.g. methane) too. To get round the problem, bi-layer sensors have been developed. Such tin oxide based functionally gradient bi-layer sensors have different compositions at the top and bottom layers. Here, instead of adsorbing the VOCs, they are allowed to interact and are consumed on the top layer of the sensors and a combustible gas like methane being less reactive, penetrates the top layer and interacts with the bottom layer. By modifying the chemical compositions of the top and bottom layers and by designing the electrode-lead wire arrangement properly, the top layer can be kept electrically shunted from the bottom layer and the electrical signal generated at the bottom layer from the combustible gas is collected. Such functionally gradient sensors, being very reliable, can find applications in domestic, industrial and strategic sectors.

  20. Optical response of Al/Ti bilayer transition edge sensors

    International Nuclear Information System (INIS)

    We report the optical response characteristics of Al/Ti bilayer transition edge sensors (TESs), which are mainly comprised of Al/Ti bilayer thermometers and suspended SiN membranes for thermal isolation. The measurement was performed in a 3He sorption refrigerator and the device's response to optical pulses was investigated using a pulsed laser source. Based on these measurements, we obtained the effective recovery time (τeff) of the devices at different biases and discussed the dependence of τeff on the bias. The device with a 940 μm × 940 μm continuous suspended SiN membrane demonstrated a fast response speed with τeff = 3.9 μs, which indicates a high temperature sensitivity (α = T/R · dR/dT = 326). The results also showed that the TES exhibits good linearity under optical pulses of variable widths. (interdisciplinary physics and related areas of science and technology)

  1. Micropatterning of nanoparticle films by bilayer lift-off

    International Nuclear Information System (INIS)

    Nanostructured films are deposited by a new technique that matches supersonic cluster beam deposition with flame spray pyrolysis production of nanoparticles (FlameBeam). These films are structured with micrometric lateral resolution, applying a lift-off method by pre-structuring a photoresist-PMMA bilayer with a suitable ‘mushroom-like’ cross-section, depositing a nanostructured silver film on top and lifting off the bilayer in an aqueous solution. Optical inspection revealed that line-shaped microstructures, having a minimal width of up to 3 µm, can be successfully obtained. The nanostructured films have survived the aqueous treatment, as demonstrated by electron microscopy imaging and electrical characterization through 4-point measurement method (Van-der-Pauw). The latter has been possible through sputtered gold pads that were realized on the substrate prior to the deposition of the photoresist and of the nanostructured film. These results disclose novel possibilities in the fine patterning of FlameBeam-deposited films and their integration into microelectromechanical systems devices in general. (paper)

  2. Nanometer Scale Hard/Soft Bilayer Magnetic Antidots.

    Science.gov (United States)

    Béron, Fanny; Kaidatzis, Andreas; Velo, Murilo F; Arzuza, Luis C C; Palmero, Ester M; Del Real, Rafael P; Niarchos, Dimitrios; Pirota, Kleber R; García-Martín, José Miguel

    2016-12-01

    The effect of arrays of nanometer scale pores on the magnetic properties of thin films has been analyzed. Particularly, we investigated the influence of the out-of-plane magnetization component created by the nanopores on the in-plane magnetic behavior of patterned hard/soft magnetic thin films in antidot morphology. Its influence on the coupling in Co/Py bilayers of few tens of nanometer thick is compared for disordered and ordered antidots of 35-nm diameter. The combination of magneto-optical Kerr effect (MOKE) and first-order reversal curve (FORC) technique allows probing the effects of the induced perpendicular magnetization component on the bilayer magnetic behavior, while magnetic force microscopy (MFM) is used to image it. We found that ordered antidots yield a stronger out-of-plane component than disordered ones, influencing in a similar manner the hard layer global in-plane magnetic behavior if with a thin or without soft layer. However, its influence changes with a thicker soft layer, which may be an indication of a weaker coupling. PMID:26873261

  3. The Influence of the Recommended LRFD Guidelines for the Seismic Design of Highway Bridges on Virginia Bridges

    OpenAIRE

    Widjaja, Matius Andy

    2003-01-01

    THE INFLUENCE OF THE RECOMMENDED LRFD GUIDELINES FOR THE SEISMIC DESIGN OF HIGHWAY BRIDGES ON VIRGINIA BRIDGES by Matius A. Widjaja Committee Chairwoman: Prof. Carin Roberts-Wollmann Civil Engineering (ABSTRACT) The influence of the recommended LRFD Guidelines for the seismic design of highway bridges in Virginia was investigated by analyzing two existing bridges. The first bridge has prestressed concrete girders and is located in the Richmond area. The second bridge has...

  4. Track-Bridge Longitudinal Interaction of Continuous Welded Rails on Arch Bridge

    Directory of Open Access Journals (Sweden)

    Rong Chen

    2013-01-01

    Full Text Available Taking arch bridges, including deck, half-through, and through arch bridges (short for DAB, HTAB, and TAB as examples, mechanics analysis models of longitudinal interaction between continuously welded rails (short for CWRs and arch bridges are established. Based on the finite element method (FEM, the longitudinal interaction calculation software of CWR on arch bridges has been developed. Focusing on an HTAB, the tension, compression, and deflection conditions are calculated and analyzed. The results show that the mechanics analysis models of three types of arch bridges can truly reflect the real state of the structure; the calculation software can be used for systematic research of the CWR on arch bridge; as for HTAB, temperature difference of arch rib has a small effect on rail tension/compression, and arch bridge can be simplified as a continuous beam for rail tension/compression additional force calculation; in calculation of deflection conditions of HTAB, it is suggested that train loads are arranged on half span and full span and take the direction of load entering bridge into account. Additionally, the deflection additional force variation of CFST basket handle arch bridge is different from that of ordinary bridge.

  5. Signal and noise in bridging PCR

    Directory of Open Access Journals (Sweden)

    Thaler David S

    2002-07-01

    Full Text Available Abstract Background In a variant of the standard PCR reaction termed bridging, or jumping, PCR the primer-bound sequences are originally on separate template molecules. Bridging can occur if, and only if, the templates contain a region of sequence similarity. A 3' end of synthesis in one round of synthesis that terminates in this region of similarity can prime on the other. In principle, Bridging PCR (BPCR can detect a subpopulation of one template that terminates synthesis in the region of sequence shared by the other template. This study considers the sensitivity and noise of BPCR as a quantitative assay for backbone interruptions. Bridging synthesis is also important to some methods for computing with DNA. Results In this study, BPCR was tested over a 328 base pair segment of the E. coli lac operon and a signal to noise ratio (S/N of approximately 10 was obtained under normal PCR conditions with Taq polymerase. With special precautions in the case of Taq or by using the Stoffel fragment the S/N was improved to 100, i.e. 1 part of cut input DNA yielded the same output as 100 parts of intact input DNA. Conclusions In the E. coli lac operator region studied here, depending on details of protocol, between 3 and 30% per kilobase of final PCR product resulted from bridging. Other systems are expected to differ in the proportion of product that is bridged consequent to PCR protocol and the sequence analyzed. In many cases physical bridging during PCR will have no informational consequence because the bridged templates are of identical sequence, but in a number of special cases bridging creates, or, destroys, information.

  6. Bridge and brick motifs in complex networks

    Science.gov (United States)

    Huang, Chung-Yuan; Sun, Chuen-Tsai; Cheng, Chia-Ying; Hsieh, Ji-Lung

    2007-04-01

    Acknowledging the expanding role of complex networks in numerous scientific contexts, we examine significant functional and topological differences between bridge and brick motifs for predicting network behaviors and functions. After observing similarities between social networks and their genetic, ecological, and engineering counterparts, we identify a larger number of brick motifs in social networks and bridge motifs in the other three types. We conclude that bridge and brick motif content analysis can assist researchers in understanding the small-world and clustering properties of network structures when investigating network functions and behaviors.

  7. Partially entangled states bridge in quantum teleportation

    Science.gov (United States)

    Cai, Xiao-Fei; Yu, Xu-Tao; Shi, Li-Hui; Zhang, Zai-Chen

    2014-10-01

    The traditional method for information transfer in a quantum communication system using partially entangled state resource is quantum distillation or direct teleportation. In order to reduce the waiting time cost in hop-by-hop transmission and execute independently in each node, we propose a quantum bridging method with partially entangled states to teleport quantum states from source node to destination node. We also prove that the designed specific quantum bridging circuit is feasible for partially entangled states teleportation across multiple intermediate nodes. Compared to two traditional ways, our partially entanglement quantum bridging method uses simpler logic gates, has better security, and can be used in less quantum resource situation.

  8. Active Control of Long Bridges Using Flaps

    DEFF Research Database (Denmark)

    Hansen, H. I.; Thoft-Christensen, Palle

    The main problem in designing ultra-long span suspension bridges is flutter. A solution to this problem might be to introduce an active flap control system to increase the flutter wind velocity. The investigated flap control system consists of flaps integrated in the bridge girder so each flap is...... different flap configurations for a bridge section model by using aerodynamic derivatives for a flat plate. The example shows that different flap configurations can either increase or decrease the flutter wind velocity. for optimal flap configurations flutter will not occur....

  9. Human Errors and Bridge Management Systems

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Nowak, A. S.

    Human errors are divided in two groups. The first group contains human errors, which effect the reliability directly. The second group contains human errors, which will not directly effect the reliability of the structure. The methodology used to estimate so-called reliability distributions on...... basis of reliability profiles for bridges without human errors are extended to include bridges with human errors. The first rehabilitation distributions for bridges without and with human errors are combined into a joint first rehabilitation distribution. The methodology presented is illustrated for...

  10. Maxwell Tension Supports the Water Bridge

    OpenAIRE

    Widom, A.; Srivastava, Y. N.; Swain, J.; Sivasubramanian, S.

    2008-01-01

    A cylindrical flexible cable made up of pure fluid water can be experimentally spanned across a spatial gap with cable endpoints fixed to the top edges of two glass beakers. The cable has been called a water bridge in close analogy to iron cables employed to build ordinary span bridges. A necessary condition for the construction of a water bridge is that a large electric field exists parallel to and located within the water cable. Presently, there is no accepted detailed theory which quantita...

  11. Building the clinical bridge: an Australian success.

    Science.gov (United States)

    Wallis, Marianne; Chaboyer, Wendy

    2012-01-01

    Nursing effectiveness science includes primary, secondary, and translational, clinically focused research activities which aim to improve patient or client outcomes. It is imperative, for the successful conduct of a program of nursing effectiveness science, that a clinical bridge is established between academic and healthcare service facilities. An Australian example of the development of a robust clinical bridge through the use of jointly funded positions at the professorial level is outlined. In addition, an analysis of the practical application of Lewin's model of change management and the contribution of both servant and transformational leadership styles to the bridge building process is provided. PMID:22577536

  12. Pilot testing of a hydraulic bridge exciter

    OpenAIRE

    Andersson Andreas; Ülker-Kaustell Mahir; Borg Richard; Dymén Olivier; Carolin Anders; Karoumi Raid

    2015-01-01

    This paper describes the development of a hydraulic bridge exciter and its first pilot testing on a full scale railway bridge in service. The exciter is based on a hydraulic load cylinder with a capacity of 50 kN and is intended for controlled dynamic loading up to at least 50 Hz. The load is applied from underneath the bridge, enabling testing while the railway line is in service. The system is shown to produce constant load amplitude even at resonance. The exciter is used to experimentally ...

  13. The effects of cryosolvents on DOPC-β-sitosterol bilayers determined from molecular dynamics simulations.

    Science.gov (United States)

    Hughes, Zak E; Malajczuk, Chris J; Mancera, Ricardo L

    2013-03-28

    Polyhydroxylated alcohols and DMSO are common cryosolvents that can damage cell membranes at sufficiently high concentrations. The interaction of representative plant cell membranes composed of mixed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-β-sitosterol bilayers, at a range of compositions, with a variety of cryosolvent molecules (DMSO, propylene glycol, ethylene glycol, glycerol, and methanol) has been investigated using molecular dynamics simulations. All the cryosolvents cause the bilayers to thin and become disordered; however, DMSO and propylene glycol have a greater disordering effect on the bilayer. Propylene glycol is shown to have the ability to cause the formation of pores in pure DOPC bilayers in a manner similar to that previously shown for DMSO. As the concentration of β-sitosterol within the bilayer increases, the membranes become more resistant to the deleterious effects of the cryosolvents. All three polyhydroxylated species are observed to form hydrogen bonds to multiple phospholipid molecules, effectively acting as cross-linkers, with glycerol being the most effective cross-linker. Increases in the concentration of β-sitosterol reduce overall hydrogen bonding of the bilayer with the cryosolvents as well as cross-linking, with glycerol and ethylene glycol being the most affected. The ability of all of these cryosolvents to affect the integrity of cell membranes appears to be the result of the balance of their ability to disorder lipid bilayers, to diffuse across them, and to interact with the lipid head groups. PMID:23445456

  14. Role of substrate induced electron–phonon interactions in biased graphitic bilayers

    Science.gov (United States)

    Davenport, A. R.; Hague, J. P.

    2016-08-01

    Bilayers of graphitic materials have potential applications in field effect transistors (FETs). A potential difference applied between certain ionic bilayers made from insulating graphitic materials such as BN, ZnO and AlN could reduce gap sizes, turning them into useful semiconductors. On the other hand, opening of a small semiconducting gap occurs in graphene bilayers under applied field. The aim here is to investigate to what extent substrate induced electron–phonon interactions (EPIs) modify this gap change. We examine EPIs in several lattice configurations of graphitic bilayers, using a perturbative approach. The typical effect of EPIs on the ionic bilayers is an undesirable gap widening. The size of this gap change varies considerably with lattice structure and the magnitude of the bias. When bias is larger than the non-interacting gap size, EPIs have the smallest effect on the bandgap, especially in configurations with A{{A}\\prime} and AB structures. Thus careful selection of substrate, lattice configuration and bias strength to minimise the effects of EPIs could be important for optimising the properties of electronic devices. We use parameters related to BN in this article. In practice, the results presented here are broadly applicable to other graphitic bilayers, and are likely to be qualitatively similar in metal dichalcogenide bilayers such as MoS2, which are already of high interest for their use in FETs.

  15. Role of substrate induced electron-phonon interactions in biased graphitic bilayers.

    Science.gov (United States)

    Davenport, A R; Hague, J P

    2016-08-17

    Bilayers of graphitic materials have potential applications in field effect transistors (FETs). A potential difference applied between certain ionic bilayers made from insulating graphitic materials such as BN, ZnO and AlN could reduce gap sizes, turning them into useful semiconductors. On the other hand, opening of a small semiconducting gap occurs in graphene bilayers under applied field. The aim here is to investigate to what extent substrate induced electron-phonon interactions (EPIs) modify this gap change. We examine EPIs in several lattice configurations of graphitic bilayers, using a perturbative approach. The typical effect of EPIs on the ionic bilayers is an undesirable gap widening. The size of this gap change varies considerably with lattice structure and the magnitude of the bias. When bias is larger than the non-interacting gap size, EPIs have the smallest effect on the bandgap, especially in configurations with [Formula: see text] and AB structures. Thus careful selection of substrate, lattice configuration and bias strength to minimise the effects of EPIs could be important for optimising the properties of electronic devices. We use parameters related to BN in this article. In practice, the results presented here are broadly applicable to other graphitic bilayers, and are likely to be qualitatively similar in metal dichalcogenide bilayers such as MoS2, which are already of high interest for their use in FETs. PMID:27346288

  16. The effect of temperature on supported dipalmitoylphosphatidylcholine (DPPC) bilayers: structure and lubrication performance.

    Science.gov (United States)

    Wang, Min; Zander, Thomas; Liu, Xiaoyan; Liu, Chao; Raj, Akanksha; Wieland, D C Florian; Garamus, Vasil M; Willumeit-Römer, Regine; Claesson, Per Martin; Dėdinaitė, Andra

    2015-05-01

    Phospholipids fulfill an important role in joint lubrication. They, together with hyaluronan and glycoproteins, are the biolubricants that sustain low friction between cartilage surfaces bathed in synovial fluid. In this work we have investigated how the friction force and load bearing capacity of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers on silica surfaces are affected by temperature, covering the temperature range 25-52°C. Friction forces have been determined utilizing the AFM colloidal probe technique, which showed that DPPC bilayers are able to provide low friction forces over the whole temperature interval. However, the load bearing capacity is improved at higher temperatures. We interpret this finding as being a consequence of lower rigidity and higher self-healing capacity of the DPPC bilayer in the liquid disordered state compared to the gel state. The corresponding structure of solid supported DPPC bilayers at the silica-liquid interface has been followed using X-ray reflectivity measurements, which suggests that the DPPC bilayer is in the gel phase at 25°C and 39°C and in the liquid disordered state at 55°C. Well-defined bilayer structures were observed for both phases. The deposited DPPC bilayers were also imaged using AFM PeakForce Tapping mode, and these measurements indicated a less homogeneous layer at temperatures below 37°C. PMID:25596372

  17. Multi-Stacked Supported Lipid Bilayer Micropatterning through Polymer Stencil Lift-Off

    Directory of Open Access Journals (Sweden)

    Yujie Zhu

    2015-08-01

    Full Text Available Complex multi-lamellar structures play a critical role in biological systems, where they are present as lamellar bodies, and as part of biological assemblies that control energy transduction processes. Multi-lamellar lipid layers not only provide interesting systems for fundamental research on membrane structure and bilayer-associated polypeptides, but can also serve as components in bioinspired materials or devices. Although the ability to pattern stacked lipid bilayers at the micron scale is of importance for these purposes, limited work has been done in developing such patterning techniques. Here, we present a simple and direct approach to pattern stacked supported lipid bilayers (SLBs using polymer stencil lift-off and the electrostatic interactions between cationic and anionic lipids. Both homogeneous and phase-segregated stacked SLB patterns were produced, demonstrating that the stacked lipid bilayers retain lateral diffusivity. We demonstrate patterned SLB stacks of up to four bilayers, where fluorescence resonance energy transfer (FRET and quenching was used to probe the interactions between lipid bilayers. Furthermore, the study of lipid phase behaviour showed that gel phase domains align between adjacent layers. The proposed stacked SLB pattern platform provides a robust model for studying lipid behaviour with a controlled number of bilayers, and an attractive means towards building functional bioinspired materials or devices.

  18. Corrugation of Phase-Separated Lipid Bilayers Supported by Nanoporous Silica Xerogel Surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Goksu, E I; Nellis, B A; Lin, W; Satcher Jr., J H; Groves, J T; Risbud, S H; Longo, M L

    2008-10-30

    Lipid bilayers supported by substrates with nanometer-scale surface corrugations holds interest in understanding both nanoparticle-membrane interactions and the challenges of constructing models of cell membranes on surfaces with desirable properties, e.g. porosity. Here, we successfully form a two-phase (gel-fluid) lipid bilayer supported by nanoporous silica xerogel. Surface topology, diffusion, and lipid density in comparison to mica-supported lipid bilayers were characterized by AFM, FRAP, FCS, and quantitative fluorescence microscopy, respectively. We found that the two-phase lipid bilayer follows the xerogel surface contours. The corrugation imparted on the lipid bilayer results in a lipid density that is twice that on a flat mica surface. In direct agreement with the doubling of actual bilayer area in a projected area, we find that the lateral diffusion coefficient (D) of lipids on xerogel ({approx}1.7 {micro}m{sup 2}/s) is predictably lower than on mica ({approx}4.1 {micro}m{sup 2}/s) by both FRAP and FCS techniques. Furthermore, the gel-phase domains on xerogel compared to mica were larger and less numerous. Overall, our results suggest the presence of a relatively defect-free continuous two-phase bilayer that penetrates approximately midway into the first layer of {approx}50 nm xerogel beads.

  19. Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids

    Directory of Open Access Journals (Sweden)

    Isabel Baeza

    2012-12-01

    Full Text Available Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in those with preeclampsia; these antibodies have also been documented in an experimental murine model of lupus, in which they are associated with immunopathology. Here, we demonstrate the presence of antibodies against non-bilayer phospholipid arrangements containing mycolic acids in the sera of lepromatous leprosy (LL patients, but not those of healthy volunteers. The presence of antibodies that recognise these non-bilayer lipid arrangements may contribute to the hypergammaglobulinaemia observed in LL patients. We also found IgM and IgG anti-cardiolipin antibodies in 77% of the patients. This positive correlation between the anti-mycolic-non-bilayer arrangements and anti-cardiolipin antibodies suggests that both types of antibodies are produced by a common mechanism, as was demonstrated in the experimental murine model of lupus, in which there was a correlation between the anti-non-bilayer phospholipid arrangements and anti-cardiolipin antibodies. Antibodies to non-bilayer lipid arrangements may represent a previously unrecognised pathogenic mechanism in LL and the detection of these antibodies may be a tool for the early diagnosis of LL patients.

  20. A Comparison of Half Bridge & Full Bridge Isolated DC-DC Converters for Electrolysis Application

    OpenAIRE

    R.Samuel Rajesh Babu; Joseph Henry

    2011-01-01

    This paper presents a comparison of half bridgeand full bridge isolated, soft-switched, DC-DC converters forElectrolysis application. An electrolyser is a part of renewableenergy system which generates hydrogen from water electrolysisthat used in fuel cells. A DC-DC converter is required to coupleelectrolyser to system DC bus. The proposed DC-DC converter isrealized in both full-bridge and half-bridge topology in order toachieve zero voltage switching for the power switches and toregulate the...

  1. Practical Approach to Fragility Analysis of Bridges

    Directory of Open Access Journals (Sweden)

    Yasamin Rafie Nazari

    2012-12-01

    Full Text Available Damages during past earthquakes reveal seismic vulnerability of bridge structures and the necessity of probabilistic approach toward seismic performance evaluation of bridges and its interpretation in terms of decision variables such as repair cost, downtime and life loss. This Procedure involves hazard analysis, structural analysis, damage analysis and loss analysis. The purpose of present study is reviewing different methods developed to derive fragility curves for damage analysis of bridges and demonstrating a simple procedure for fragility analysis using Microsoft Office Excel worksheet to reach probability of occurring predefined level of damage due to different levels of seismic demand parameters. The input of this procedure is the intensity of ground motion and the output is an appropriate estimate of the expected damage. Different observed damages of the bridges are discussed and compared the practical definition of damage states. Different methods of fragility analyses are discussed and a practical step by step example is illustrated.

  2. Active aerodynamic stabilisation of long suspension bridges

    DEFF Research Database (Denmark)

    Nissen, Henrik Ditlev; Sørensen, Paul Haase; Jannerup, Ole Erik

    2004-01-01

    use of control analysis and design techniques, a linear model of the structural and aerodynamic motion around equilibriun is developed. The model is validated through comparison with finite element calculations and wind tunnel experimental data on the Great Belt East Bridge in Denmark. The developed......The paper describes the addition of actively controlled appendages (flaps) attached along the length of the bridge deck to dampen wind-induced oscillations in long suppension bridges. A novel approach using control systems methods for the analysis of dynamic stability is presented. In order to make...... active control scheme is local in that the flap control signal at a given longitudinal position along the bridge only depends on local motion measurements. The analysis makes use of the Nyquist stability criteria and an anlysis of the sensitivity function for stability analysis. The analysis shows that...

  3. Bridging the Chasm between Policymakers and Educators.

    Science.gov (United States)

    Marshall, Catherine

    1988-01-01

    In an attempt to lessen the tension which often exists between educators and policymakers, this article discusses each sector's world and then offers suggestions on how to construct bridges between these worlds so that mutual goals may be attained. (JL)

  4. Allegheny County-Owned Bridges Points

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset shows the location of bridges owned by Allegheny County as centroids. If viewing this description on the Western Pennsylvania Regional Data Center’s...

  5. Allegheny County-Owned Bridges Centerlines

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset shows the bridges owned by Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open data portal...

  6. Pilot testing of a hydraulic bridge exciter

    Directory of Open Access Journals (Sweden)

    Andersson Andreas

    2015-01-01

    Full Text Available This paper describes the development of a hydraulic bridge exciter and its first pilot testing on a full scale railway bridge in service. The exciter is based on a hydraulic load cylinder with a capacity of 50 kN and is intended for controlled dynamic loading up to at least 50 Hz. The load is applied from underneath the bridge, enabling testing while the railway line is in service. The system is shown to produce constant load amplitude even at resonance. The exciter is used to experimentally determine frequency response functions at all sensor locations, which serve as valuable input for model updating and verification. An FE-model of the case study bridge has been developed that is in good agreement with the experimental results.

  7. Identifying hidden sexual bridging communities in Chicago.

    Science.gov (United States)

    Youm, Yoosik; Mackesy-Amiti, Mary Ellen; Williams, Chyvette T; Ouellet, Lawrence J

    2009-07-01

    Bridge populations can play a central role in the spread of human immunodeficiency virus (HIV) by providing transmission links between higher and lower prevalence populations. While social network methods are well suited to the study of bridge populations, analyses tend to focus on dyads (i.e., risk between drug and/or sex partners) and ignore bridges between distinct subpopulations. This study takes initial steps toward moving the analysis of sexual network linkages beyond individual and risk group levels to a community level in which Chicago's 77 community areas are examined as subpopulations for the purpose of identifying potential bridging communities. Of particular interest are "hidden" bridging communities; that is, areas with above-average levels of sexual ties with other areas but whose below-average AIDS prevalence may hide their potential importance for HIV prevention. Data for this analysis came from the first wave of recruiting at the Chicago Sexual Acquisition and Transmission of HIV Cooperative Agreement Program site. Between August 2005 through October 2006, respondent-driven sampling was used to recruit users of heroin, cocaine, or methamphetamine, men who have sex with men regardless of drug use, the sex partners of these two groups, and sex partners of the sex partners. In this cross-sectional study of the sexual transmission of HIV, participants completed a network-focused computer-assisted self-administered interview, which included questions about the geographic locations of sexual contacts with up to six recent partners. Bridging scores for each area were determined using a matrix representing Chicago's 77 community areas and were assessed using two measures: non-redundant ties and flow betweenness. Bridging measures and acquired immunodeficiency syndrome (AIDS) case prevalence rates were plotted for each community area on charts representing four conditions: below-average bridging and AIDS prevalence, below-average bridging and above

  8. Experimental study of single span railway bridges

    OpenAIRE

    Rigueiro, Constança; Rebelo, C.; Silva, L. Simões da

    2007-01-01

    The main purpose of this paper is to present some results concerning the investigation that has been done by the authors regarding the dynamic response of small to médium span railway bridges using response acceleration data colleted during the measurements carried out on single span bridges on the railway track Linz-Wels, in Austria. Using output-only methods in this experimental program, it was possible to have an estimation of the igenfrequencies, mode shapes and the corresponding viscous ...

  9. Active control of vibrations in pedestrian bridges

    OpenAIRE

    Álvaro Cunha; Carlos Moutinho

    1999-01-01

    This paper, apart from making a brief general reference to vibration problems in pedestrian bridges, as well as to the form of modelling of dynamic pedestrian loads, presents the use of a predictive control strategy for the numerical simulation of the dynamic response of actively controlled structures of this type. The consideration of this control strategy permitted the development of a computational model, which was applied to the study of a pedestrian cable-stayed bridge, in order to show ...

  10. Acoustic Emission Health Monitoring of Steel Bridges

    OpenAIRE

    Pahlavan, Pooria Lotfollah; Paulissen, Joep; Pijpers, Richard; Hakkesteegt, Henk; Jansen, Rob

    2014-01-01

    Despite extensive developments in the field of Acoustic Emission (AE) for monitoring fatigue cracks in steel structures, the implementation of AE systems for large-scale bridges is hindered by limitations associated with instrumentation costs and signal processing complexities. This paper sheds light on some of the most important challenges in the utilization of AE systems for steel bridge decks. These challenges are mainly related to the multi-modal character of guided waves, and the expensi...

  11. Building Organic Bridges: Volume 1, Argentina - France

    OpenAIRE

    Rahmann, Gerold; Aksoy, Uygun

    2014-01-01

    [Foreword ...] The 18th IFOAM Organic World Congress held on 13-15 October, 2014 in Istanbul-Turkey targets to 'build organic bridges'. The Scientific track will contribute to bridging not only scientists but also institutions and disciplines, and to linking more developed and less developed, rural and urban, research to extension, plant to animal, farm practices to world-wide problems and producer and consumers. Organic is a management system that requires a diversity of inputs from differen...

  12. Building Organic Bridges: Volume 2, Germany - India

    OpenAIRE

    Rahmann, Gerold; Aksoy, Uygun

    2014-01-01

    [Foreword ...] The 18th IFOAM Organic World Congress held on 13-15 October, 2014 in Istanbul-Turkey targets to 'build organic bridges'. The Scientific track will contribute to bridging not only scientists but also institutions and disciplines, and to linking more developed and less developed, rural and urban, research to extension, plant to animal, farm practices to world-wide problems and producer and consumers. Organic is a management system that requires a diversity of inputs from differen...

  13. Differential Local Spasticity in Myocardial Bridges

    OpenAIRE

    Angelini, Paolo; Uribe, Carlo; Lozano, Pablo

    2012-01-01

    To illustrate the effect of myocardial bridges on coronary vascular tone, we describe the cases of 2 patients with different clinical presentations in the context of reproducible increased spasticity at the site of myocardial bridging. One had an episode of takotsubo cardiomyopathy, and one developed typical Prinzmetal angina while receiving desmopressin treatment for pituitary insufficiency. In both patients, acetylcholine challenge clearly revealed both the presence and the severity of myoc...

  14. Noise measurements in superconducting proximity bridges

    International Nuclear Information System (INIS)

    Experiments and analsis have been done to show that the low-frequency noise voltage developed across a current-biased proximity-coupled superconducting bridge is well described by existing theories of electron tunneling. There is also some evidence that, on a two-fluid model, normal and supercurrent noise may be correlated. The temperature sensitivity of these bridges is calculated from the measured noise spectrum and is found to compare favorably with existing bolometric techniques

  15. Thermal Bridge Effects in Walls Separating Rowhouses

    DEFF Research Database (Denmark)

    Rose, Jørgen

    1997-01-01

    In this report the thermal bridge effects at internal wall/roof junctions in rowhouses are evaluated. The analysis is performed using a numerical calculation programme, and different solutions are evaluated with respect to extra heat loss and internal surface temperatures.......In this report the thermal bridge effects at internal wall/roof junctions in rowhouses are evaluated. The analysis is performed using a numerical calculation programme, and different solutions are evaluated with respect to extra heat loss and internal surface temperatures....

  16. The evaluation of bicycle paths on bridges

    OpenAIRE

    Wang, Hwa-chyi; De Backer, Hans; Lauwers, Dirk; Chang, SK Jason

    2016-01-01

    Bicycle accidents have increasingly caused casualties and property damage. Many countries have therefore started to pay more attention to designing the space of bicycle paths. However, few studies have focused on the design of bicycle continuity between each bicycle path. In this study, the concept of using both spatial crash probability (P) and crash severity index (CSI) is introduced to address the bicycle safety issue on bridges in Central Business Districts (CBDs). Bicycle paths on bridge...

  17. External Prestressing Bridge Reinforcement Technology Review

    Directory of Open Access Journals (Sweden)

    Zhu Hanbing

    2015-01-01

    Full Text Available Externally prestressed bridge can not only limit and reduce the cracks and deformation of the structure, improve the rigidity and bearing capacity of structure, improve the stress state of structure, but also have less interference for bridge operation when it is operating and have the good economic efficiency. This paper introduces the advantages and disadvantages of external prestressed strengthening technique, its calculation theory and construction technology described in detail, and finally the paper discusses the deficiency of existing research.

  18. Subscapularis Tendon Repair Using Suture Bridge Technique

    OpenAIRE

    Park, Yong Bok; Park, Young Eun; Koh, Kyoung Hwan; Lim, Tae Kang; Shon, Min Soo; Yoo, Jae Chul

    2015-01-01

    The subscapularis tendon plays an essential role in shoulder function. Although subscapularis tendon tears are less common than other rotator cuff tears, tears of the subscapularis tendon have increasingly been recognized with the advent of magnetic resonance imaging and arthroscopy. A suture bridge technique for the treatment of posterosuperior rotator cuff tears has provided the opportunity to improve the pressurized contact area and mean footprint pressure. However, suture bridge fixation ...

  19. Assessment of a Bridge WIM System on Integral Concrete Bridges and on Steel Orthotropic Decks

    OpenAIRE

    Ieng, Sio Song; SCHMIDT, Franziska; ROMBONI, Frédéric; Jacob, Bernard

    2011-01-01

    Bridge-Weigh-In-Motion uses bridges as a scale to weigh vehicles. Practically, this is done by measuring the strains in that bridge, and relating them to the weight and dimensions of a truck called “calibration trucks” whose shape and axle weights are well known. This article summarizes different B-WIM experiments the institute IFSTTAR (formerly called LCPC) realized and the lessons drawn from this experience. First, the system has been tested on frame-type bridges with integral s...

  20. Inspection Based Evaluation of a Danish Road Bridge

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper it is shown how an inspection-based evaluation of a Danish road bridge may be performed using the BRIDGE1 and BRIDGE2 bridge management systems produced within the EC-supported research programme "Assessment of Performance and Optimal Strategies for Inspection and Maintenance of Con...... Concrete Structures using Reliability Based Expert Systems"....