WorldWideScience

Sample records for bicycles

  1. Bicycle Commuting

    OpenAIRE

    Heinen, E

    2011-01-01

    Cycling is cheaper, healthier and in urban environments often faster than other transport modes. Nevertheless, even at short distances, many individuals do not cycle. This thesis aims to explain why commuters vary in their decision to bicycle. Results indicate that the individual (day-to-day) choice to commute by bicycle is affected by personal attitudes towards cycling to work, social norms, work situation, weather conditions and trip characteristics. Additionally, this thesis provides evide...

  2. Bicycling injuries.

    Science.gov (United States)

    Silberman, Marc R

    2013-01-01

    Bicycling injuries can be classified into bicycle contact, traumatic, and overuse injuries. Despite the popularity of cycling, there are few scientific studies regarding injuries. Epidemiological studies are difficult to compare due to different methodologies and the diverse population of cyclists studied. There are only three studies conducted on top level professionals. Ninety-four percent of professionals in 1 year have experienced at least one overuse injury. Most overuse injuries are mild with limited time off the bike. The most common site of overuse injury is the knee, and the most common site of traumatic injury is the shoulder, with the clavicle having the most common fracture. Many overuse and bicycle contact ailments are relieved with simple bike adjustments.

  3. Bicycle accidents.

    Science.gov (United States)

    Lind, M G; Wollin, S

    1986-01-01

    Information concerning 520 bicycle accidents and their victims was obtained from medical records and the victims' replies to questionnaires. The analyzed aspects included risk of injury, completeness of accident registrations by police and in hospitals, types of injuries and influence of the cyclists' age and sex, alcohol, fatigue, hunger, haste, physical disability, purpose of cycling, wearing of protective helmet and other clothing, type and quality of road surface, site of accident (road junctions, separate cycle paths, etc.) and turning manoeuvres.

  4. Solar Bicycle

    OpenAIRE

    S. Sridhar; HARSHENDRA. N. SHET. K

    2011-01-01

    The running costs of the present vehicles are rising day by day hence common man is looking for an alternate mode of transport, with low fuel and maintenance cost. Solar bicycle is an attempt to meet these needs. It is an environmentally sustainable and zero running cost vehicle. It uses photovoltaic cells to absorb energy from sunlight. The absorbed energy is stored in battery. The hub motor mounted on the rear wheel uses this energy to run the cycle. A fully charged battery gives a mileage ...

  5. Solar Bicycle

    Directory of Open Access Journals (Sweden)

    SRIDHAR. S

    2011-07-01

    Full Text Available The running costs of the present vehicles are rising day by day hence common man is looking for an alternate mode of transport, with low fuel and maintenance cost. Solar bicycle is an attempt to meet these needs. It is an environmentally sustainable and zero running cost vehicle. It uses photovoltaic cells to absorb energy from sunlight. The absorbed energy is stored in battery. The hub motor mounted on the rear wheel uses this energy to run the cycle. A fully charged battery gives a mileage of 15-20 km. It is also provided with manual pedaling which increases the cycle’s mileage further. Average speed of the cycle is 15-18 kmph.

  6. Lost Kingdom of Bicycles?

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    For most people born in the 1950s and '60s, the bicycle was a faithful companion of their youth, when China was known as a kingdom of bicycles. A bicycle ride was a favorite pastime during a colorful spring day or in the crisp

  7. Bicycle Detection System

    OpenAIRE

    Yu, James; Arellano , Secundino; Carrillo , Alma; Cruz , Melinda; Kunitskiy, Dmitriy; Maynigo , Marlo; Sell , Monica

    2013-01-01

    Project Description:  Bicycle detection has become a popular feature of high demand in cities and agencies across the United States. California has recently mandated that all new limit line detector installations as well as modifications to existing limit line detection must provide bicycle detection. This has created the need to develop detection methodologies which are able to detect bicycles as well as differentiate them from vehicles. The objective of this project is to utilize Econolite ...

  8. Recumbent bicycle design

    OpenAIRE

    Basso Puig, Carlos

    2014-01-01

    The subject of this project is the design of a recumbent bicycle prototype. A recumbent bike is a type of bicycle in which the rider mounts in a reclined position. In order to do this, we will learn about these bicycles by showing the different types there are, its evolution over the years, and so on. After that, it is shown the recumbent bicycle design and all its components. It has been invented the frame and so, it is explained the material choice, a brief anthropometric study and FE...

  9. Bicycle Safety in Action.

    Science.gov (United States)

    National Commission on Safety Education, Washington, DC.

    This material was designed to assist schools in teaching bicycle safety. As the population grows and competition for road space increases, it is more imperative than ever that we concentrate attention on the need for caution among pupil cyclists. The pamphlet: (1) discusses the role of bicycle safety in classroom instruction and in student…

  10. Butchers and Bicycles

    DEFF Research Database (Denmark)

    Kahle, Lynn; Eriksen, Steen Mandsfelt

    2016-01-01

    Morten Wagener is a Danish design, and innovator who founded the cargo and personal transportation bicycle company, ”Butchers and Bicycles,”. He identified a business opportunity to improve the future of urban transport. His idea was that most of the trikes) on the market lacked good design, mane...

  11. Bicycling and Hostels.

    Science.gov (United States)

    Kyle, George M., Ed.

    1974-01-01

    This collection of articles focuses on bicycling and hosteling as important recreational activities that can (a) help conserve energy, (b) benefit the economy offering a low-cost pasttime, and (c) stimulate foreign travel to the U.S. Articles include the following: (a) "Bicycling and Hosteling--An American Partnership," (b) "The Return of the…

  12. Bicycles made to measure

    NARCIS (Netherlands)

    Van Dijk, T.

    2007-01-01

    For almost a century and a half, mathematicians have been racking their brains about the bike. How can a rolling bicycle be so stable of its own accord? Delft researchers now say they have completed the model to end all models. Bicycle manufacturer Batavus intends to use it to make better bikes for

  13. Butchers and Bicycles

    OpenAIRE

    Kahle, Lynn; Eriksen, Steen Mandsfelt

    2016-01-01

    Morten Wagener is a Danish design, and innovator who founded the cargo and personal transportation bicycle company, ”Butchers and Bicycles,”. He identified a business opportunity to improve the future of urban transport. His idea was that most of the trikes) on the market lacked good design, maneuverability and styling. With his engineering and design background, Wagener set out to design a new trike; which would meet the needs of the target market, which his research identified as well- educ...

  14. Bicycle Culture in Denmark

    OpenAIRE

    Pedersenn, Pia; Breitenstein, Marcus Lindgaard; Nilsson, Asbjørn Lupo

    2014-01-01

    The research area involves the cycling culture in Denmark. Cycling is one of the main forms of transport in Denmark today, and it has been a big part of Denmark’s culture since the early 20th century. This project specifically looks at bicycle helmets. Today in Denmark, there is no legislation demanding cyclists to wear helmets. However we would like to investigate what the government’s stance is concerning bicycle helmets. The project will begin by looking at the efficiency of helmets. Some ...

  15. Electric Bicycle Design

    OpenAIRE

    Tovar López, Carlos

    2009-01-01

    The thesis consists of the design of an electric bike. Based on the analysis of the needs arising from urban transport in Sweden and its people.We wanted to develop a bicycle that could be manufactured in the coming years and be widely accepted by the Swedish population and later also in Europe.

  16. Bicycles and Valentines

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Shanghai municipality's announcement late last year that bicycles were to be banned from the city's main thoroughfares was ill received by many residents. The measure was taken to relieve traffic congestion and reflects how traditional modes of transport fail to meet the changing needs of Chinese contemporary life.

  17. The safety of electrically assisted bicycles compared to classic bicycles.

    Science.gov (United States)

    Schepers, J P; Fishman, E; den Hertog, P; Wolt, K Klein; Schwab, A L

    2014-12-01

    Use of electrically assisted bicycles with a maximum speed of 25 km/h is rapidly increasing. This growth has been particularly rapid in the Netherlands, yet very little research has been conducted to assess the road safety implications. This case-control study compares the likelihood of crashes for which treatment at an emergency department is needed and injury consequences for electric bicycles to classic bicycles in the Netherlands among users of 16 years and older. Data were gathered through a survey of victims treated at emergency departments. Additionally, a survey of cyclists without any known crash experience, drawn from a panel of the Dutch population acted as a control sample. Logistic regression analysis is used to compare the risk of crashes with electric and classical bicycles requiring treatment at an emergency department. Among the victims treated at an emergency department we compared those being hospitalized to those being send home after the treatment at the emergency department to compare the injury consequences between electric and classical bicycle victims. The results suggest that, after controlling for age, gender and amount of bicycle use, electric bicycle users are more likely to be involved in a crash that requires treatment at an emergency department due to a crash. Crashes with electric bicycles are about equally severe as crashes with classic bicycles. We advise further research to develop policies to minimize the risk and maximize the health benefits for users of electric bicycles.

  18. Electric power generating bicycle

    OpenAIRE

    Brito, Nuno; Ribeiro, Luís; Esteves, João Sena

    2006-01-01

    It is manifest the growing interest in both personal health and environmental issues. The device described on this paper contemplates both aspects: generating environment-friendly electric power while keeping fit. A car alternator excited through a 12V battery is coupled to a mountain bicycle, and this arrangement enables the lighting of six halogen lamps, if a cyclist pedals fast enough. Such a machine gives rise to the thought of a self-powered gymnasium. Considerable physical effort is req...

  19. The Bicycle Assembly Line Game

    Science.gov (United States)

    Klotz, Dorothy

    2011-01-01

    "The Bicycle Assembly Line Game" is a team-based, in-class activity that helps students develop a basic understanding of continuously operating processes. Each team of 7-10 students selects one of seven prefigured bicycle assembly lines to operate. The lines are run in real-time, and the team that operates the line that yields the…

  20. Bicycle Rider Control: Observations, Modeling & Experiments

    NARCIS (Netherlands)

    Kooijman, J.D.G.

    2012-01-01

    Bicycle designers traditionally develop bicycles based on experience and trial and error. Adopting modern engineering tools to model bicycle and rider dynamics and control is another method for developing bicycles. This method has the potential to evaluate the complete design space, and thereby dev

  1. [Prevention of bicycle accidents].

    Science.gov (United States)

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  2. [Prevention of bicycle accidents].

    Science.gov (United States)

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  3. Design of an electric bicycle

    OpenAIRE

    Cabré Viñeta, Anna

    2010-01-01

    The purpose of this study is to make an electrical bicycle. As this bike has an electrical motor, it will not be used as a sport method, the main idea is to use it as a public transport so people can move from side to side of the city without traffic, without pollution and without getting tired. Once selected the purpose of the bicycle, it is necessary to take into account the main features that it must have. A bicycle used as a transport around the city needs to be easy to ...

  4. Control for an Autonomous Bicycle

    OpenAIRE

    Getz, Neil H.; Marsden, J. E.

    1995-01-01

    The control of nonholonomic and underactuated systems with symmetry is illustrated by the problem of controlling a bicycle. We derive a controller which, using steering and rear-wheel torque, causes a model of a riderless bicycle to recover its balance from a near fall as well as converge to a time parameterized path in the ground plane. Our construction utilizes new results for both the derivation of equations of motion for nonholonomic systems with symmetry, as well as the control of undera...

  5. Valuing public investments to support bicycling

    OpenAIRE

    Götschi, Thomas; Hintermann, Beat

    2014-01-01

    We develop a framework for assessing the net benefits of investments to promote bicycling, which explicitly accounts for internal costs of bicycling. We apply our model to eight Swiss cities using data from the Swiss national travel survey and find that increasing the level of bicycling by reducing internal costs leads to inframarginal benefits that exceed the net benefits from the additional bicycling.  We further find that Swiss cyclists only partially internalize health benefits, which aff...

  6. The Bicycle Rental Market In Hangzhou

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    On May 1, 2008, Hangzhou, capital of east China’s Zhejiang Province, included bicycle rentals in the public transportation system. Now, bicycles have become the most convenient form of transport for Hangzhou residents. Data from the Hangzhou Bureau of Transportation show that on average each bicycle gets rented five times a day.

  7. EP BICYCLE POOL - VIGNETTES 2002

    CERN Multimedia

    EP-SMI Help Desk

    2002-01-01

    The vignettes (insurance certificates) for 2002 become obligatory from 1 June. If you have a bicycle from the EP Pool, please bring it to the EP-SMI Help Desk (Building 124) on any working day up to 31 May between 8h.30 - 12h.00 or 13h.30 - 17h.30. EP-SMI Help Desk

  8. Proper fit of the bicycle.

    Science.gov (United States)

    Burke, E R

    1994-01-01

    After cyclists have carefully made adjustments for proper fit, minor aches and pains may develop before the body adjusts to the new riding posture. This is normal--so resist the temptation to fiddle with the position much. They will become accustomed to the new riding position after a few rides, and cycling performance will be improved. Then they can concentrate on bike handling skills and fitness confident that their riding position is as good as can be. Proper bicycle fit requires careful review of bicycle selection, saddle height for proper leg extension, fore-and-aft positioning of the knee over the pedal, saddle tilt, handlebar position, and positioning of the upper body for optimum comfort and performance. Further research on the effects of maintaining an aerodynamic position for extended periods of time needs to be investigated to review fatigue patterns in lower and upper body musculature. The underlying principle of positioning a cyclist on a bicycle is to remember that the bicycle is adjustable, and the cyclist is adaptable. PMID:8111846

  9. Road characteristics and bicycle accidents.

    Science.gov (United States)

    Nyberg, P; Björnstig, U; Bygren, L O

    1996-12-01

    In Umeå, Sweden, defects in the physical road surface contributed to nearly half of the single bicycle accidents. The total social cost of these injuries to people amount to at least SEK 20 million (SEK 60,000 or about USD 8,500 per accident), which corresponds to the estimated loss of "eight life equivalents a year". Improved winter maintenance seems to have the greatest injury prevention potential and would probably reduce the number of injuries considerably, whereas improved road quality and modification of kerbs would reduce the most severe injuries. A local traffic safety program should try to prevent road accidents instead of handling the consequences of them. In accordance with Parliament decisions on traffic we would like to see increased investment in measures favoring bicycle traffic, where cycling is seen as a solution, not as a problem.

  10. Characterisation of Electric Bicycles Performances

    OpenAIRE

    Cappelle, Jan; Lataire, Philippe; Maggetto, Gaston; Meeusen, Roman; Kempenaers, Farid

    2002-01-01

    The proposed paper reports on characterisation work performed in the scope of the E-tour project. This project has already been presented at EVS-18. At the ‘Vrije Universiteit Brussel’ different EPACs (Electric Power Assisted Cycles) are put at the public’s disposal for testing. To quantify the performances of these electrical bicycles we want to link the subjective experienced driving comfort to some measurable objective parameters. For this purpose we converted a treadmill in...

  11. A study on electric bicycle energy efficiency

    Directory of Open Access Journals (Sweden)

    Ivan EVTIMOV

    2015-09-01

    Full Text Available The paper presents a construction of an experimental electric bicycle for evaluation of the energy efficiency. The bicycle is equipped with onboard computer which can store the information about motion and energy consumption. The result concerning power, energy consumption, recharging during brake process, etc. are given. Energy consumption for 3 typical city routes is studied.

  12. Bicycle parking preferences: costs versus walking time

    NARCIS (Netherlands)

    Molin, E.J.E.; Maat, K.

    2014-01-01

    Successful bicycle stimulating policies may increase the need for bicycle parking capacity, especially at main railway stations located in city centers. A potential solution for this problem involves combining paid surveyed indoor parking near the platforms and free open-air parking without surveill

  13. Stabilizing a Bicycle: A Modeling Project

    Science.gov (United States)

    Pennings, Timothy J.; Williams, Blair R.

    2010-01-01

    This article is a project that takes students through the process of forming a mathematical model of bicycle dynamics. Beginning with basic ideas from Newtonian mechanics (forces and torques), students use techniques from calculus and differential equations to develop the equations of rotational motion for a bicycle-rider system as it tips from…

  14. Bicycle helmet use and bicycling-related injury among young Canadians: an equity analysis

    Science.gov (United States)

    2013-01-01

    Introduction Cycling is a major activity for adolescents in Canada and potential differences exist in bicycling-related risk and experience of injury by population subgroup. The overall aim of this study was to inform health equity interventions by profiling stratified analytic methods and identifying potential inequities associated with bicycle-related injury and the use of bicycle helmets among Canadian youth. The two objectives of this study were: (1) To examine national patterns in bicycle ridership and also bicycle helmet use among Canadian youth in a stratified analysis by potentially vulnerable population subgroups, and (2) To examine bicycling-related injury in the same population subgroups of Canadian youth in order to identify possible health inequities. Methods Data for this study were obtained from the 6th cycle (2009/10) of the Health Behaviour in School-aged Children (HBSC) study, which is a general health survey that was completed by 26,078 students in grades 6–10 from 436 Canadian schools. Based on survey responses, we determined point prevalence for bicycle ridership, bicycle helmet use and relative risks for bicycling-related injury. Results Three quarters of all respondents were bicycle riders (n=19,410). Independent factors associated with bicycle ridership among students include being male, being a younger student, being more affluent, and being a resident of a small town. Among bicycle riders, 43% (95%CI ± 0.6%) reported never wearing and 32% (± 0.6%) inconsistently wearing a helmet. Only 26% (± 0.5%) of students reported always wearing a bicycle helmet. Helmets were less frequently used among older students and there were also important patterns by sex, geographic location and socioeconomic status. Adjusting for all other demographic characteristics, boys reported 2.02-fold increase (95% CI: 1.61 to 1.90) and new immigrants a 1.35-fold increase (95%CI: 1.00 to1.82) in the relative risk of bicycling-related injury in the past 12 months

  15. STRESS ANALYSIS OF BICYCLE FRAME

    Directory of Open Access Journals (Sweden)

    Mr.M.V.Pazare

    2014-06-01

    Full Text Available This paper deals with the stress analysis of bicycle frame by using Finite Element Method. The analysis is carried out in Ansys, The F.E.A. results are compared with theoretical results. In theoretical analysis the frame is treated as truss like structure and the stresses in various members of frame like top tube, down tube, seat tube, chain stay and seat stay are determined, considering various condition like, static start up, steady state paddling, vertical impact, horizontal impact, rear wheel braking. Also Finite Element Analysis is done considering the above conditions. From the analysis it is found that there is a good agreement between analytical and F.E.A. results. Result of all the cases reveals that maximum stress is found in top tube of the bicycle frame as compared to other frame members and is equal to 24.84 MPa which is less than yield strength in tension (i.e.Syt = 290 MPa for the material (aluminum T 6061 selected.

  16. Electric bicycles in The Netherlands: Current developments and future possibilities

    NARCIS (Netherlands)

    Rooijen, T. van

    2010-01-01

    Developments with electric bicycles in the Netherlands are progressing rapidly. The number of electric bicycles sold is rises every year. Cycling is a very popular mode of transport in The Netherlands. In 2008 more than one million bicycles were sold. At the moment one out of ten bicycles sold is al

  17. Survey of options on legalizing bicycling (VB)

    DEFF Research Database (Denmark)

    Zwahlen, Jurg; Sulewski, Sharon; Sacovitch, Stephen;

    1999-01-01

    the opposition against the proposal was.The goal of this project was to identify categories of users that were opposed to bicycling on the Dosseringen of the Østerbro and Nørrebro District lakes in Copenhagen. The identification of the opposition and its strength, rationale and organization was in terms of age......, gender, residency, frequency of use and their utilization of the area (i.e. walking, jogging, bicycling) as compared to the support for bicycling in the area. This was an Interactive Qualifying Project (IQP), that was designed to merge technical and scientific knowledge with society, and stresses...... the importance of this interaction....

  18. A Sociological Analysis of the Relationship between Attitude towards Bicycle and Using Bicycle in Short Trips in Isfahan

    Directory of Open Access Journals (Sweden)

    Siroos Ahmadi

    2013-07-01

    The main goal of this research is to investigate relationship between attitude toward bicycle and using bicycle among the men in Isfahan. Based on the descriptive research findings, mean using bicycle score is low in Iran. This situation is not satisfactory for a metropolis such as Isfahan that has an increasing population and motor vehicles, and also has many difficulties in urban base facilities and must be changed. In addition to mean attitude toward bicycle is high that is an opportunity for urban planners. Inferential findings show that attitude toward bicycle has a significant impact on using bicycle. In other words, increase attitude toward bicycle means an increase in using bicycle for short trips. This research finding theoretically confirm relation between attitude and behavior. Moreover it is compatible with results of the research that show there is significant relationship between attitude toward bicycle and using bicycle. There is an inverse significant relationship between age and using bicycle and with rising age using bicycle is decreased. This research finding shows that urban infrastructure in Isfahan for using bicycle is not available and consequently with rising age, bicycle risk is increased. There is a direct significant relationship between income rate and using bicycle and with increasing income rate, using bicycle is also increased. This research finding is rooted in social prestige bicycle and higher classes prefer to use motor vehicle for transportation instead of bicycle. There is a significant relationship between marital status and using bicycle and single men use bicycle more than married men but there is no significant relationship between education level and using bicycle. This research findings show that with rising education level in spite of rising income, using bicycle is not decreased. And finally there is no significant relationship between employed and unemployed persons in using bicycle. On the basis of the evidences such

  19. Synthesis of Caged Bicyclic Phosphate Derivatives

    Institute of Scientific and Technical Information of China (English)

    FANG Xiao-min; OU Yu-xiang; LUO Rui-bin; WANG Yong; LIAN Dan-jun; LI Xin

    2008-01-01

    Seven caged bicyclic phosphate compounds were synthesized by using 1-oxo-4-hydroxymethy1-2,6,7-trioxa-1-pho-sphabicyclo[2.2.2] octane (PEPA) as starting material. Within them were three PEPA derivatives containing single caged bicyclic phosphate structure(1a,2a,3a), another three PEPA deviratives containing two caged bicyclic phosphate structures(1b,2b,3b) and one devirative(1c) containing three caged bicyclic phosphate structures. Structures of the products were characterized by FTIR, 1H NMR, elemental analysis and TG analysis. The reaction conditions were also discussed. Thermal analysis showed they had high thermal stability and excellent char-forming ability. Besides, these compounds had pentaerythritol bone and flame retardant elements of phosphorus, bromine or nitrogen simultaneously in their molecules, endowed them with good fire retardancy, and made them can be used as intumescent flame retardant.

  20. 36 CFR 1004.30 - Bicycles.

    Science.gov (United States)

    2010-07-01

    ... routes designated for bicycle use; provided, however, that the Board may close any Presidio Trust road or... consistent with the protection of natural, scenic and aesthetic values, safety considerations and...

  1. 36 CFR 4.30 - Bicycles.

    Science.gov (United States)

    2010-07-01

    ... road or parking area to bicycle use pursuant to the criteria and procedures of §§ 1.5 and 1.7 of this... consistent with the protection of a park area's natural, scenic and aesthetic values, safety...

  2. Public Bicycle Share Programs and Head Injuries

    Science.gov (United States)

    Pless, Barry; Moore, Lynne; Nathens, Avery B.; Hunte, Garth; Rivara, Frederick P.

    2014-01-01

    Objectives. We evaluated the effect of North American public bicycle share programs (PBSPs), which typically do not offer helmets with rentals, on the occurrence of bicycle-related head injuries. Methods. We analyzed trauma center data for bicycle-related injuries from 5 cities with PBSPs and 5 comparison cities. We used logistic regression models to compare the odds that admission for a bicycle-related injury would involve a head injury 24 months before PBSP implementation and 12 months afterward. Results. In PBSP cities, the proportion of head injuries among bicycle-related injuries increased from 42.3% before PBSP implementation to 50.1% after (P < .01). This proportion in comparison cities remained similar before (38.2%) and after (35.9%) implementation (P = .23). Odds ratios for head injury were 1.30 (95% confidence interval = 1.13, 1.67) in PBSP cities and 0.94 (95% confidence interval = 0.79, 1.11) in control cities (adjusted for age and city) when we compared the period after implementation to the period before. Conclusions. Results suggest that steps should be taken to make helmets available with PBSPs. Helmet availability should be incorporated into PBSP planning and funding, not considered an afterthought following implementation. PMID:24922150

  3. Bicycling to school improves the cardiometabolic risk factor profile

    DEFF Research Database (Denmark)

    Ostergaard, Lars; Børrestad, Line A B; Tarp, Jakob;

    2012-01-01

    To investigate whether bicycling to school improves cardiometabolic risk factor profile and cardiorespiratory fitness among children.......To investigate whether bicycling to school improves cardiometabolic risk factor profile and cardiorespiratory fitness among children....

  4. Bicycle helmet promotion programs--Canada, Australia, and United States.

    Science.gov (United States)

    1993-03-26

    The use of bicycle helmets substantially reduces the risk for serious head injuries during bicycle-related crashes. Despite this benefit, epidemiologic data indicate a worldwide low prevalence of helmet use. Strategies to increase the use of bicycle helmets in the United States and other countries include subsidies, legislation, and education. This report summarizes information regarding three strategies to increase bicycle helmet use and the impact of implementing these approaches in Canada (helmet subsidies), Australia (legislation), and the United States (education). PMID:8446097

  5. On the stability of a bicycle on rollers

    Energy Technology Data Exchange (ETDEWEB)

    Cleary, Patricia A [Department of Geosciences, University of Wisconsin-Parkside, Kenosha, WI 53141 (United States); Mohazzabi, Pirooz, E-mail: pirooz.mohazzabi@uwp.edu [Department of Physics, University of Wisconsin-Parkside, Kenosha, WI 53141 (United States)

    2011-09-15

    Riding a bicycle on the newest form of indoor training, rollers, presents a unique experiment on bicycle stability. The stability factors eliminated by riding on rollers are discussed in terms of refined handling and control of the centre of mass on a bicycle. This paper is intended for undergraduate physics majors as well as any other general readership interested in the dynamics of bicycle stability.

  6. Beijing Bicycle - Stories from a Transformative Space

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2012-01-01

    ’s Beijing Bicycle can be understood as the result of stories-so-far, as the cinematic representation of the globalized ”space” within the setting of the national. Beijing Bicycle is a production of space as well as a space of production, since it tells a new story in the trajectory of stories......Ideas, words, images and stories travel from west to east – and from east to west. Stories are chosen and retold in different settings and images are reproduced and appropriated into new contexts – and in new times. Cinema, in this case the mainland Chinese, becomes both a space of production...... and a production of space that reveals how transnational and translocal mechanisms affect the cinematic language, transforming the images and stories chosen for the cinematic representation. Wang Xiaoshuai’s Beijing Bicycle (Shiqi Sui de Danche) (2001) is a result of transnational currents weaving the carpet...

  7. On the Stability of a Bicycle on Rollers

    Science.gov (United States)

    Cleary, Patricia A.; Mohazzabi, Pirooz

    2011-01-01

    Riding a bicycle on the newest form of indoor training, rollers, presents a unique experiment on bicycle stability. The stability factors eliminated by riding on rollers are discussed in terms of refined handling and control of the centre of mass on a bicycle. This paper is intended for undergraduate physics majors as well as any other general…

  8. An Analysis of Florida Physical Educators' Knowledge of Bicycle Laws

    Science.gov (United States)

    Connaughton, Daniel P.; Egberts, John B.; Spengler, J. O.; Zhang, James J.; Jin, Liyan

    2012-01-01

    Bicycling among youth is a popular activity, but like all modes of travel it is not without risk. Florida has a particularly high rate of bicycle-related fatalities and injuries. To reduce such risks, the Florida Department of Transportation and Florida Department of Education have developed a youth bicycle safety educational program (Florida…

  9. Successful Swiss solar bicycles in Australia

    International Nuclear Information System (INIS)

    The article takes a look at the Swiss 'Spirit of Bike' team's success in the 'Power Challenge' race across Australia using solar-bicycles based on commercially available models. Apart from the sporting aspects of race, technical details on the cycles and their supply of solar power are given. Also, the history behind the success of the team is presented and the monitoring of man (and woman) and machine during the race is described. The article also discusses the electric bicycles that are commercially available and the potential of these energy-efficient vehicles in Switzerland

  10. Bicyclic semigroups of left I-quotients

    CERN Document Server

    Ghroda, Nassraddin

    2011-01-01

    In this article we study left I-orders in the bicyclic monoid $\\mathcal{B}$. We give necessary and sufficient conditions for a subsemigroup of $\\mathcal{B}$ to be a left I-oreder in $\\mathcal{B}$. We then prove that any left I-order in $\\mathcal{B}$ is straight.

  11. What do we know about bicycle helmets?

    NARCIS (Netherlands)

    Bogerd, C.P. Halldin, P. Houtenbos, M. Otte, D. Rossi, R.M. Walker, L. Willinger, R. & Shinar, D.

    2012-01-01

    Cycling is an excellent sustainable alternative to driving for many journeys. But cyclists have fewer safety options than car-users, with a helmet being the main safety device that is available. However, there are indications that increasing bicycle helmet usage through legislation causes confoundin

  12. 15 CFR 265.22 - Bicycle traffic.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Bicycle traffic. 265.22 Section 265.22... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE REGULATIONS GOVERNING TRAFFIC AND CONDUCT REGULATIONS GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS &...

  13. Solutions to the Triangular Bicycle Flags Problem

    Science.gov (United States)

    Hartweg, Kim

    2005-01-01

    Students in a fifth-grade general education class and a second-grade gifted class participated in the Triangular Bicycle Flags problem. The results indicated that providing students with geometric experiences at the correct van Hiele level is necessary for helping students move from one level of understanding to the next.

  14. Traffic conflicts on bicycle paths: a systematic observation of behaviour from video

    NARCIS (Netherlands)

    Horst, A.R.A. van der; Goede, M. de; Hair-Buijssen, S.H.H.M. de; Methorst, R.

    2014-01-01

    In The Netherlands, on bicycle paths, single-bicycle accidents, bicycle-bicycle and bicycle-moped accidents constitute a considerable share of all bicyclist injuries. Over three quarters of all hospitalised bicyclist victims in the Netherlands cannot be directly related to a crash with motorised tra

  15. Physiological and cognitive responses when riding an electrically assisted bicycle versus a classical bicycle.

    Science.gov (United States)

    Theurel, J; Theurel, A; Lepers, R

    2012-01-01

    The present study compared the physiological responses and the subsequent cognitive performance when riding an electrically assisted (EB) versus a classical (CB) bicycle. Oxygen uptake, heart rate and leg extensor muscles electromyographic (EMG) activity were recorded in 10 subjects during a 30-min intermittent cycling exercise performed with EB versus CB. Cognitive performance was evaluated by a mail sorting test, performed at rest and after each cycling session. Averaged oxygen uptake and heat rate were significantly (P cycling than during CB cycling. The EMG activities of the vastus lateralis, rectus femoris and gastrocnemius medialis muscles were significantly (P cycling than during EB cycling. The time to complete the mail sorting test was significantly (P cycling than after CB cycling. Because EB cycling reduced muscle strains and physiological stress, it might offer benefits for those using bicycles in their work, such as postal workers and police officers. STATEMENT OF RELEVANCE: This study compared physiological and cognitive responses when riding an electrically assisted versus a classical bicycle. The results showed that the electrically assisted bicycle led to reduced muscle strains and physiological stress and, therefore, might offer benefits for those using bicycles in their work, such as postal workers and police officers. PMID:22506555

  16. Fatal falls from bicycles: a case report.

    Science.gov (United States)

    Venara, A; Mauillon, D; Gaudin, A; Rouge-Maillart, C; Jousset, N

    2013-03-10

    Though rare occurrences, fatal falls from bicycles are generally linked to the absence of a protective helmet and/or a collision with another vehicle. The case presented here is exceptional due to its circumstances and the consequences of the accident: a fall with no obstacle at a low speed that brought about multiple traumas and the death of a cyclist wearing a protective helmet. Comparing this against a review of cyclist accidentology literature, this case is unique. The increased use of autopsy in terms of forensic accidentology is to be encouraged so as not to misunderstand the possibility of such lesion-based consequences following a simple fall from a bicycle. PMID:23312586

  17. Maximum Estrada Index of Bicyclic Graphs

    CERN Document Server

    Wang, Long; Wang, Yi

    2012-01-01

    Let $G$ be a simple graph of order $n$, let $\\lambda_1(G),\\lambda_2(G),...,\\lambda_n(G)$ be the eigenvalues of the adjacency matrix of $G$. The Esrada index of $G$ is defined as $EE(G)=\\sum_{i=1}^{n}e^{\\lambda_i(G)}$. In this paper we determine the unique graph with maximum Estrada index among bicyclic graphs with fixed order.

  18. Applying riding-posture optimization on bicycle frame design.

    Science.gov (United States)

    Hsiao, Shih-Wen; Chen, Rong-Qi; Leng, Wan-Lee

    2015-11-01

    Customization design is a trend for developing a bicycle in recent years. Thus, the comfort of riding a bike is an important factor that should be paid much attention to while developing a bicycle. From the viewpoint of ergonomics, the concept of "fitting object to the human body" is designed into the bicycle frame in this study. Firstly, the important feature points of riding posture were automatically detected by the image processing method. In the measurement process, the best riding posture was identified experimentally, thus the positions of feature points and joint angles of human body were obtained. Afterwards, according to the measurement data, three key points: the handlebar, the saddle and the crank center, were identified and applied to the frame design of various bicycle types. Lastly, this study further proposed a frame size table for common bicycle types, which is helpful for the designer to design a bicycle. PMID:26154206

  19. Free Use of Bicycles at CERN

    CERN Multimedia

    2000-01-01

    Imagine you have just arrived at CERN. You are from Russia or Japan and have no car but you do need to get around and do not like depending on public transport. What do you do? You go to the EP Service Point (Building 124) and meet Boris Cabaud to get a CERN bicycle. Use of the bicycle is free but you have to fill in an application form which needs to be signed by your Group or Division Secretary. Then the application is filled in, you are put on the waiting list and it might take you from one to four weeks to get your bike depending on the season. “Normally the bikes are only for Users in the EP division as they are paid for by the EP budget,” says Boris, “but some other divisions have made arrangements to cover the costs.” Boris takes care of 350 bicycles at present. Each bike can be lent for maximum one year. During the winter the bikes can be stored in building 301 as it is difficult to ride them in the snow. If a bike is broken or lost all costs will be billed to the group or team account of the bo...

  20. Psychological Delaying Model of Bicycle Passing Events on Physically Separated Bicycle Roadways in China*

    Science.gov (United States)

    Zhao, De; Wang, Wei; Li, Zhibin; Shan, Xiaonian; Sun, Xin

    Bicycle facilities are quite common in China but there are not enough quantitative methods to evaluate the Level of Service (LOS) of bicycle roadways. The number of passing events, which considers the interactions between bicyclists, has been proved to be a proper indicator for evaluating bicycle LOS under the special traffic and roadway conditions in China. The primary objective of this study is to propose a model considering the delay effects of passing events and rider's overtaking motivation. Field data was collected on South Zhongshan Road and Huaihai Road in Nanjing city of China with 639 bicyclists investigated. Then a new mathematical model was built to evaluate those effects through probability and regression analyses. It was found that the delay effect of passing events and rider's overtaking motivation are significant influencing factors which cannot be omitted. Correlation test shows the fitted relationship is greater between the model prediction and field data comparing with the previous model.

  1. Bicycling and walking are associated with different cortical oscillatory dynamics

    Directory of Open Access Journals (Sweden)

    Lena eStorzer

    2016-02-01

    Full Text Available Although bicycling and walking involve similar complex coordinated movements, surprisingly Parkinson’s patients with freezing of gait typically remain able to bicycle despite severe difficulties walking. This observation suggests functional differences in the motor networks subserving bicycling and walking. However, a direct comparison of brain activity related to bicycling and walking has never been performed, neither in healthy participants nor in patients. Such a comparison could potentially help elucidating the cortical involvement in motor control and the mechanisms through which bicycling ability may be preserved in patients with freezing of gait. The aim of this study was to contrast the cortical oscillatory dynamics involved in bicycling and walking in healthy participants.To this end, EEG and EMG data of 14 healthy participants were analyzed, who cycled on a stationary bicycle at a slow cadence of 40 revolutions per minute (rpm and walked at 40 strides per minute (spm, respectively.Relative to walking, bicycling was associated with a stronger power decrease in the high beta band (23-35 Hz during movement initiation and execution, followed by a stronger beta power increase after movement termination. Walking, on the other hand, was characterized by a stronger and persisting alpha power (8-12 Hz decrease. Both bicycling and walking exhibited movement cycle-dependent power modulation in the 24-40 Hz range that was correlated with EMG activity. This modulation was significantly stronger in walking.The present findings reveal differential cortical oscillatory dynamics in motor control for two types of complex coordinated motor behavior, i.e., bicycling and walking. Bicycling was associated with a stronger sustained cortical activation as indicated by the stronger high beta power decrease during movement execution and less cortical motor control within the movement cycle. We speculate this to be due to the more continuous nature of

  2. Technical analysis and market study of electric bicycles

    OpenAIRE

    Matasyan, Artur

    2015-01-01

    This thesis project was done in collaboration with a Prismattery LLC, which is based in Tallinn, Estonia and is interested in entering the market of electric bicycles. For that reason in this report a detailed study concerning the market of electrical bicycles, its current situation and trends were performed and a promising target market was indicated. The market study showed that although in different countries the specifications and preferred types of electric bicycles may vary,...

  3. Will a bicycle friendly policy make passenger travel more sustainably?

    OpenAIRE

    Christensen, Linda; Jensen, Thomas Christian

    2009-01-01

    The purpose of this paper is to analyse the possibility to transfer a larger part of the short car trips to walking or bicycling in order to obtain environmental and health benefits. The project contains a logistic choice model used to explain which circumstances are particularly important for choosing walking and bicycling, and how very different instruments can promote walking and bicycling at the expense of short car trips. Furthermore, the paper describes the most important factors when c...

  4. Potential risk and its influencing factors for separated bicycle paths.

    Science.gov (United States)

    Xu, Cheng; Yang, Ying; Jin, Sheng; Qu, Zhaowei; Hou, Lei

    2016-02-01

    In this paper, we propose two potential risk indicators to define and evaluate the safety of bicycle path at the microscopic level. Field bicycle data were collected from three survey sites under different traffic conditions. These two risk indicators based on speed dispersion were proposed and calculated during each 5-min interval. The risk influences of various widths of bicycle path and traffic conditions were analyzed by using one-way ANOVA. We further proposed a generalized linear model (GLM) for modeling and analyzing the relationships between bicycle risks and v/c ratio and percentages of electric bicycles, male cyclists, young cyclists, and loaded cyclists. The stepwise regression models were applied for determination of coefficients. The results show that the influences of gender and age of cyclists on potential risks are not significant. The risks increase with the width of bicycle path and percentage of electric bicycles, while only for wider bicycle path (4-lane case in this study), the risks are associated with whether or not cyclists are loaded. The findings could contribute for analysis and evaluation of the safety for bicycle path. PMID:26647016

  5. Potential risk and its influencing factors for separated bicycle paths.

    Science.gov (United States)

    Xu, Cheng; Yang, Ying; Jin, Sheng; Qu, Zhaowei; Hou, Lei

    2016-02-01

    In this paper, we propose two potential risk indicators to define and evaluate the safety of bicycle path at the microscopic level. Field bicycle data were collected from three survey sites under different traffic conditions. These two risk indicators based on speed dispersion were proposed and calculated during each 5-min interval. The risk influences of various widths of bicycle path and traffic conditions were analyzed by using one-way ANOVA. We further proposed a generalized linear model (GLM) for modeling and analyzing the relationships between bicycle risks and v/c ratio and percentages of electric bicycles, male cyclists, young cyclists, and loaded cyclists. The stepwise regression models were applied for determination of coefficients. The results show that the influences of gender and age of cyclists on potential risks are not significant. The risks increase with the width of bicycle path and percentage of electric bicycles, while only for wider bicycle path (4-lane case in this study), the risks are associated with whether or not cyclists are loaded. The findings could contribute for analysis and evaluation of the safety for bicycle path.

  6. The relationship between public and private bicycle use: the case of Seville

    OpenAIRE

    José I. Castillo-Manzano; Castro-Nuño, Mercedes; Lopez-Valpuesta, Lourdes

    2015-01-01

    Despite the success achieved by Public Bicycle Sharing Systems (PBSS) across the world, several researchers provide evidence on their limitations and constraints in a medium-long term, and bicycle ownership may be considered as a complementary tool to promote a 'bicycle-culture'. This paper aims to cover the gap about the interaction between both systems (public bicycle / private bicycle) and which are the key aspects to explain the bicycle-buying decision. After a fieldwork based on surveys ...

  7. Bicycle Sharing in Developing Countries : A proposal towards sustainable transportation in Brazilian median cities

    OpenAIRE

    Dias Batista, Edgard

    2010-01-01

    Bicycle-sharing programs are a new trend in urban transportation. The main difference of a bicycle-sharing program with a regular bicycle rental is that is possible to get a bicycle in one station and return it in any other station. There are many models of bicycle sharing, each model with its pros and cons. This study analyzes the bicycle-sharing models in order to build a proposal of a bicycle-sharing program suitable for Brazilian median cities. The study begins with an overview of bicycle...

  8. Bicycle Helmet Laws are Associated with a Lower Fatality Rate from Bicycle-Motor Vehicle Collisions

    Science.gov (United States)

    Meehan, William P.; Lee, Lois K.; Fischer, Christopher M.; Mannix, Rebekah C.

    2013-01-01

    Objective To assess the association between bicycle helmet legislation and bicycle-related deaths sustained by children involved in bicycle-motor vehicle collisions. Study design We conducted a cross sectional study of all bicyclists aged 0-16 years included in the Fatality Analysis Reporting System (FARS) who died between January 1999 and December 2010. We compared fatality rates per age-specific state populations between states with helmet laws and those without helmet laws. We used a clustered Poisson multivariate regression model to adjust for factors previously associated with rates of motor vehicle fatalities: elderly driver licensure laws, legal blood alcohol limit ( 0.08 between states with helmet laws and those without helmet laws. The mean unadjusted rates of fatalities were lower in states with helmet laws (2.0/1,000,000 vs. 2.5/1,000,000; p= 0.03). After adjusting for potential confounding factors, states with mandatory helmet laws continued to be associated with a lower rate of fatalities (adjusted Incidence Rate Ratio 0.84; 95% CI 0.70, 0.98). Conclusions Bicycle helmet safety laws are associated with a lower incidence of fatalities among child bicyclists involved in motor vehicle collisions. PMID:23706604

  9. Bicycle Freewheeling with Air Drag as a Physics Experiment

    Science.gov (United States)

    Janssen, Paul; Janssens, Ewald

    2015-01-01

    To familiarize first-year students with the important ingredients of a physics experiment, we offer them a project close to their daily life: measuring the effect of air resistance on a bicycle. Experiments are done with a bicycle freewheeling on a downhill slope. The data are compared with equations of motions corresponding to different models…

  10. Methods to assess the stability of a bicycle rider system

    NARCIS (Netherlands)

    Cooke, A.G.; Bulsink, V.E.; Beusenberg, C.M.; Dubbeldam, R.; Bonnema, G.M.; Poelman, W.A.; Koopman, H.F.J.M.

    2012-01-01

    The SOFIE (Intelligent Assisted Bicycles) project wishes to create performance and design guidelines for mechatronic appliances which improve the stability of electric bicycles, so-called intelligent stability assist devices (IAD). To achieve this goal, a stability hypothesis, an advanced rider/bicy

  11. Modeling of speed distribution for mixed bicycle traffic flow

    Directory of Open Access Journals (Sweden)

    Cheng Xu

    2015-11-01

    Full Text Available Speed is a fundamental measure of traffic performance for highway systems. There were lots of results for the speed characteristics of motorized vehicles. In this article, we studied the speed distribution for mixed bicycle traffic which was ignored in the past. Field speed data were collected from Hangzhou, China, under different survey sites, traffic conditions, and percentages of electric bicycle. The statistics results of field data show that the total mean speed of electric bicycles is 17.09 km/h, 3.63 km/h faster and 27.0% higher than that of regular bicycles. Normal, log-normal, gamma, and Weibull distribution models were used for testing speed data. The results of goodness-of-fit hypothesis tests imply that the log-normal and Weibull model can fit the field data very well. Then, the relationships between mean speed and electric bicycle proportions were proposed using linear regression models, and the mean speed for purely electric bicycles or regular bicycles can be obtained. The findings of this article will provide effective help for the safety and traffic management of mixed bicycle traffic.

  12. Bicycle facilities on road segments and intersections of distributor roads.

    NARCIS (Netherlands)

    2008-01-01

    A sustainably safe road environment requires bicycle facilities that separate motorized traffic from relatively vulnerable road users like cyclists. Research indicates that on distributor roads the road sections with adjoining or separate bicycle tracks are safer than the road sections without any b

  13. On Wiener polarity index of bicyclic networks

    Science.gov (United States)

    Ma, Jing; Shi, Yongtang; Wang, Zhen; Yue, Jun

    2016-01-01

    Complex networks are ubiquitous in biological, physical and social sciences. Network robustness research aims at finding a measure to quantify network robustness. A number of Wiener type indices have recently been incorporated as distance-based descriptors of complex networks. Wiener type indices are known to depend both on the network’s number of nodes and topology. The Wiener polarity index is also related to the cluster coefficient of networks. In this paper, based on some graph transformations, we determine the sharp upper bound of the Wiener polarity index among all bicyclic networks. These bounds help to understand the underlying quantitative graph measures in depth.

  14. Solar Electric Bicycle Body Modeling and Simulation

    Directory of Open Access Journals (Sweden)

    Zhikun Wang

    2013-10-01

    Full Text Available A new solar electric bicycle design and study were carried out on in this paper. Application of CAD technology to establish three-dimension geometric model, using the kinetic analysis on the frame and other parts for numerical simulation and static strength analysis for the vehicle model design, virtual assembly, complete frame dynamics analysis and vibration analysis, with considering other factors, first on the frame structure improvement, second on security of design calculation analysis and comparison, finally get the ideal body design.

  15. Revitalization of Cycling in a Former Bicycle Kingdom: Beijing

    DEFF Research Database (Denmark)

    Zhao, Chunli; Carstensen, Trine Agervig; Olafsson, Anton Stahl;

    are revealed by collection and analysis of historical material and interviews with key stakeholders. The historical material is obtained from libraries, online resources, and reports from professionals including urban designers, transportation engineers, research centres and politicians of the Beijing......This paper scrutinizes and analyses the relevant historical policy documents chronologically - from the 1960s to the present - in order to figure out the potentials of revitalizing the bicycle mode share in Beijing. Firstly, we targeted two top-drawer conflicts of the bicycle use, which are travel......- or commuting distance and motorised vehicle-oriented urban development. Secondly, we analysed how the various related policies resulted in the changing landscape of the bicycle mode share, including increasing in the bicycle mode share, created the conflicts and declined the bicycle mode share. The results...

  16. Safety effects of permanent running lights for bicycles

    DEFF Research Database (Denmark)

    Madsen, Jens Chr. Overgaard; Andersen, T.; Lahrmann, Harry

    2013-01-01

    Making the use of daytime running lights mandatory for motor vehicles is generally documented to have had a positive impact upon traffic safety. Improving traffic safety for bicyclists is a focal point in the road traffic safety work in Denmark. In 2004 and 2005 a controlled experiment including...... 3845 cyclists was carried out in Odense, Denmark in order to examine, if permanent running lights mounted to bicycles would improve traffic safety for cyclists. The permanent running lights were mounted to 1845 bicycles and the accident rate was recorded through 12 months for this treatment group......, including all recorded bicycle accidents with personal injury to the participating cyclist, is 19% lower for cyclists with permanent running lights mounted; indicating that the permanent bicycle running light significantly improves traffic safety for cyclists. The study shows that use of permanent bicycle...

  17. Infiuence of Bicycle Traffic on Capacity of Typical Signalized Intersection

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; YUE Hao

    2007-01-01

    Bicycle traffic has a significant effect on the capacity of signalized intersections. This paper divides the influence of bicyclists on vehicular flow into four types with the time durations estimated based on probability, shock wave, and gap acceptance theory. Vehicular saturation flow rate is predicted for various conditions on the basis of the speed-flow curve for the capacity of typical intersections influenced by bicycle traffic.The model overcomes the limitations of the Highway Capacity Manual (HCM, 2000) method for left-turns due to data collection, and takes into account the effect of trapped bicycles on the through vehicular traffic.The numerical results show that the left-turn and through capacities predicted by the model are lower than those of the HCM method. The right-turn capacity is close to that of the HCM method at Iow bicycle volumes and higher than that of the HCM method at high bicycle volumes.

  18. Safe bicycling – Problems and solutions

    Directory of Open Access Journals (Sweden)

    Grecka M.

    2014-01-01

    Full Text Available Herewith a popularity of bicycling, various safety problems of cyclists are researched. Studies are connected with infrastructure, riding culture, choice of cyclist's suit and riding equipment. Overall, 382 respondents (159 cyclists, 119 drivers, 104 pedestrians were involved in the survey. The road participants' mutual communication problems in the traffic and opportunities of solving them were clarified. Most of cyclists wear comfortable daily or sporty clothing with reflective elements, and in their opinion, clothing with light emissive elements must be like daily clothing. The drivers could better notice cyclists, if they wear brightly colored suit with light emissive and reflective elements, but pedestrians – if cyclists use warning sound signals. The opinions of road participants about the placement of light emissive and reflective elements in cyclist's clothing were clarified. The prototype of cycling belt (Fig. 1e has been drawn up with LED stop signals, which are activated by the accelerometer placed in the central back pocket. The results of approbation have shown that the sensor does not provide the proper functioning of signals, due to a high level of riding movements. Using Motion Capture technology and bicycle exercise equipment, the research of oscillation of anthropometric points on the back has been carried out. The accelerometer should be placed between scapulae to design the cycling jacket.

  19. The Design of Sport Bicycle Speed Odometer

    Directory of Open Access Journals (Sweden)

    Dongbing Liu

    2013-04-01

    Full Text Available As bicycle sport equipment, a sport bike needs a speed and distance measuring device, due to the characteristic of road cycling, thereby mastering the state of motion. According to external conditions such as temperature, wind speed, the bike can make the appropriate adjustment to achieve the best movement effect. The bicycle speed odometer is a major accessibility tool that satisfies with needs of the people with fast development. This study elaborated a bike speed odometer design based on Hall element, taking AT89C52 single chip as the core, measuring speed with A44E Hall sensor, to finish the bike mileage/speed measurement and statistics by displaying bike mileage and speed in real time. By using the Hall elements, the hardware of speed odometer input the number of pulse of per circle into the single-chip computer system. Then the signal processed by the single-chip computer displays. The software is programmed with assembly language and modular design idea. The design of the hardware circuit is simple and the subroutine has universal property, which fully meet the design requirements and possess a wide range of application and dissemination value.

  20. The effect of tyre and rider properties on the stability of a bicycle

    NARCIS (Netherlands)

    Bulsink, V.E.; Doria, A.; Belt, van de D.; Koopman, H.F.J.M.

    2015-01-01

    To work towards an advanced model of the bicycle-rider-environment system, an open-loop bicycle-rider model was developed in the commercial multibody dynamics software ADAMS. The main contribution of this article to bicycle dynamics is the analysis of tyre and rider properties that influence bicycle

  1. Helmet Wearing Among Users of a Public Bicycle-Sharing Program in the District of Columbia and Comparable Riders on Personal Bicycles

    Science.gov (United States)

    Roffenbender, Jason S.; Anderko, Laura

    2012-01-01

    Bicycle-sharing programs are increasingly popular and have the potential to increase physical activity and decrease air pollution, but anecdotal evidence suggests helmet use is lower among users of bicycle-sharing programs than cyclists on private bicycles. We conducted a cross-sectional study to assess helmet use among users of a bicycle-sharing program in Washington, DC. Helmet use was significantly lower among cyclists on shared bicycles than private bicycles, highlighting a need for targeted helmet promotion activities. PMID:22698021

  2. Improving bicycle safety: The role of paediatricians and family physicians.

    Science.gov (United States)

    Leblanc, John C; Huybers, Sherry

    2004-05-01

    Cycling is a complex activity requiring motor, sensory and cognitive skills that develop at different rates from childhood to adolescence. While children can successfully ride a two-wheeled bicycle at age five or six, judgment of road hazards are poor at that age and matures slowly until adult-like judgment is reached in early adolescence. Safe cycling depends on the care, skills and judgment of cyclists and motorists; roadway design that promotes safe coexistence of bicycles and motor vehicles; and the use of safety devices, including bicycle helmets, lights and reflective tape. Whereas, research into optimal roadway design and educational programs for drivers to improve road safety has yielded contradictory results, the benefits of bicycle helmet use and programs to enhance their use have been clearly shown. This paper has the following objectives for paediatricians and family physicians: To understand the relationship between bicycle safety and children's motor and cognitive skills.To understand the effectiveness and limitations of strategies to improve bicycle safety.To describe activities to promote bicycle safety that physicians can undertake in clinical settings and in the community. PMID:19657515

  3. The frequency of single-bicycle crashes (SBCs) in countries with varying bicycle mode shares

    DEFF Research Database (Denmark)

    Schepers, Paul; Agerholm, Niels; Amoros, Emmanuelle;

    In  order  to  encourage  cycling,  we  need  to  reduce  the  hazards  that  cyclists  face. Single-bicycle crashes or ‘bicycle-only crashes’ are falls and obstacle collisions in which only one cyclist is involved. Between 60 and 95% of cyclists admitted to hospital or treated at an emergency...... department are victims of single-bicycle crashes. As proportion of the total number of traffic casualties  the  share  exceeds  20%  in  most  countries  with  medium  to  high  levels  of cycling.  This paper  discusses  the  prevalence  of  the  problem  and  describes  measures  that  may  both reduce...... the risks and make cycling a more attractive transport choice at the same time....

  4. Symbolic derivation of bicycle kinematics with toroidal wheels

    Directory of Open Access Journals (Sweden)

    Wang Everett X.

    2015-01-01

    Full Text Available Bicycle kinematics with toroidal wheels is presented in this paper. Using symbolic mathematic tool Maple, we obtain two holonomic and four nonholonomic constraint equations due to front and rear wheels of a bicycle. We show that the two holonomic constraints cannot be expressed in quartic form for bicycle rear body pitch angle unless the minor (crown radius of the torus are the same for both the front and rear wheels. In addition, we show that all the constraints can be written in differential form, from which a constraint matrix is constructed, according to standard procedure for developing dynamics in robotics.

  5. Associations between a walkability index and bicycle use in Denmark

    DEFF Research Database (Denmark)

    Madsen, T.; Christiansen, L.; Nielsen, Thomas Alexander Sick;

    2012-01-01

    /day, and important health benefits can accrue from regular commuting cycling. Studies have shown a positive correlation between walkability attributes of neighborhood environments (street connectivity, and use mix, residential density, retail floor area ratio) and cycling. Results from Australia/Belgium show...... associations between measures of walkability and bicycle use for transport and the present study focuses on exploring whether these findings can be applied to a Danish setting where cycling culture differs and bicycle share is much higher (17% of all trips are by bicycle)...

  6. Associations between bicycling and carotid arterial stiffness in adolescents

    DEFF Research Database (Denmark)

    Ried-Larsen, M; Grøntved, A; Østergaard, Lars;

    2015-01-01

    The aim of the study was to investigate the associations between bicycling and carotid arterial stiffness, independent of objectively measured moderate-and-vigorous physical activity. This cross-sectional study included 375 adolescents (age 15.7 ± 0.4 years) from the Danish site of the European...... modulus [standard beta -0.48 (95% CI -0.91 to -0.06)]. Similar trends were observed when investigating the association between commuter bicycling and carotid arterial stiffness. These associations were not observed in girls. Our observations suggest that increasing bicycling in adolescence may...

  7. The effect of tyre and rider properties on the stability of a bicycle

    OpenAIRE

    Bulsink, V.E.; Doria, A.; Belt, van de, M.; Koopman, H.F.J.M.

    2015-01-01

    To work towards an advanced model of the bicycle-rider-environment system, an open-loop bicycle-rider model was developed in the commercial multibody dynamics software ADAMS. The main contribution of this article to bicycle dynamics is the analysis of tyre and rider properties that influence bicycle stability. A system identification method is used to extract linear stability properties from time domain analysis. The weave and capsize eigenmodes of the bicycle-rider system are analysed. The e...

  8. Bicyclic graphs with maximal revised Szeged index

    CERN Document Server

    Li, Xueliang

    2011-01-01

    The revised Szeged index $Sz^*(G)$ is defined as $Sz^*(G)=\\sum_{e=uv \\in E}(n_u(e)+ n_0(e)/2)(n_v(e)+ n_0(e)/2),$ where $n_u(e)$ and $n_v(e)$ are, respectively, the number of vertices of $G$ lying closer to vertex $u$ than to vertex $v$ and the number of vertices of $G$ lying closer to vertex $v$ than to vertex $u$, and $n_0(e)$ is the number of vertices equidistant to $u$ and $v$. Hansen used the AutoGraphiX and made the following conjecture about the revised Szeged index for a connected bicyclic graph $G$ of order $n \\geq 6$:

  9. Bicycling induced pudendal nerve pressure neuropathy.

    Science.gov (United States)

    Silbert, P L; Dunne, J W; Edis, R H; Stewart-Wynne, E G

    1991-01-01

    Pudendal neuropathies are well recognised as part of more generalised peripheral neuropathies; however, focal abnormalities of the pudendal nerve due to cycling-related injuries have been infrequently reported. We describe two patients who developed pudendal neuropathies secondary to pressure effects on the perineum from racing-bicycle saddles. Both were male competitive athletes, one of whom developed recurrent numbness of the penis and scrotum after prolonged cycling; the other developed numbness of the penis, an altered sensation of ejaculation, with disturbance of micturition and reduced awareness of defecation. Both patients improved with alterations in saddle position and riding techniques. We conclude that pudendal nerve pressure neuropathy can result from prolonged cycling, particularly when using a poor riding technique. PMID:1821826

  10. Bicycle helmet ventilation and comfort angle dependence.

    Science.gov (United States)

    Brühwiler, Paul A; Ducas, Charline; Huber, Roman; Bishop, Phillip A

    2004-09-01

    Five modern bicycle helmets were studied to elucidate some of the variations in ventilation performance, using both a heated manikin headform and human subjects (n = 7). Wind speed and head angle were varied to test their influence on the measured steady-state heat exchange (cooling power) in the skull section of the headform. The cooling power transmitted by the helmets varied from about 60% to over 90% of that of the nude headform, illustrating the range of present manufacturer designs. Angling the head forward by 30 degrees was found to provide better cooling power to the skull (up to 25%) for three of the helmets and almost equal cooling power in the remaining two cases. Comparisons of skull ventilation at these angles with human subjects strongly supported the headform results.

  11. Bamboo Bicycle – Past or Future?

    Directory of Open Access Journals (Sweden)

    Suzana Jakovljević

    2016-01-01

    Full Text Available In this article the experiment was carried out to establish tensile strength values of two different bamboo species, which are obtained by the static tensile test. The tensile strength results of two tested species Tonkin Cane and Ku Zhu bamboo are presented and compared with traditional materials used for bicycle frame to determine their suitability for designing a frame. Physiology and other properties of bamboo were elaborated as well. The purpose of this study was to gain more knowledge on bamboo and prove his suitability in use as an alternative for ecologically unacceptable materials. Therefore, application of the natural materials is essential for the sustainable development. The fact that they have unlimited resources the use of bamboo has great potential and this article explains why.

  12. Will a bicycle friendly policy make passenger travel more sustainably?

    DEFF Research Database (Denmark)

    Christensen, Linda; Jensen, Thomas Christian

    The purpose of this paper is to analyse the possibility to transfer a larger part of the short car trips to walking or bicycling in order to obtain environmental and health benefits. The project contains a logistic choice model used to explain which circumstances are particularly important...... for choosing walking and bicycling, and how very different instruments can promote walking and bicycling at the expense of short car trips. Furthermore, the paper describes the most important factors when choosing between bicycling and walking and car driving, respectively, in case of trips of up to 22 km....... Hills and temperature differences appear to be particularly impor-tant, apart from car ownership. Regarding the socio-economy, particularly the number of children is of importance. Furthermore, the paper elucidates the effect of various instruments to promote the transfer of short car trips to walking...

  13. Fluid Mechanics of a High Performance Racing Bicycle Wheel

    Science.gov (United States)

    Mercat, Jean-Pierre; Cretoux, Brieuc; Huat, Francois-Xavier; Nordey, Benoit; Renaud, Maxime; Noca, Flavio

    2013-11-01

    In 2012, MAVIC released the most aerodynamic bicycle wheel on the market, the CXR 80. The french company MAVIC has been a world leader for many decades in the manufacturing of bicycle wheels for competitive events such as the Olympic Games and the Tour de France. Since 2010, MAVIC has been in a research partnership with the University of Applied Sciences in Geneva, Switzerland, for the aerodynamic development of bicycle wheels. While most of the development up to date has been performed in a classical wind tunnel, recent work has been conducted in an unusual setting, a hydrodynamic towing tank, in order to achieve low levels of turbulence and facilitate quantitative flow visualization (PIV). After a short introduction on the aerodynamics of bicycle wheels, preliminary fluid mechanics results based on this novel setup will be presented.

  14. Improving bicycle safety: The role of paediatricians and family physicians

    OpenAIRE

    LeBlanc, John C.; Huybers, Sherry

    2004-01-01

    Cycling is a complex activity requiring motor, sensory and cognitive skills that develop at different rates from childhood to adolescence. While children can successfully ride a two-wheeled bicycle at age five or six, judgment of road hazards are poor at that age and matures slowly until adult-like judgment is reached in early adolescence. Safe cycling depends on the care, skills and judgment of cyclists and motorists; roadway design that promotes safe coexistence of bicycles and motor vehicl...

  15. On the Skill of Balancing While Riding a Bicycle.

    Science.gov (United States)

    Cain, Stephen M; Ashton-Miller, James A; Perkins, Noel C

    2016-01-01

    Humans have ridden bicycles for over 200 years, yet there are no continuous measures of how skill differs between novice and expert. To address this knowledge gap, we measured the dynamics of human bicycle riding in 14 subjects, half of whom were skilled and half were novice. Each subject rode an instrumented bicycle on training rollers at speeds ranging from 1 to 7 m/s. Steer angle and rate, steer torque, bicycle speed, and bicycle roll angle and rate were measured and steering power calculated. A force platform beneath the roller assembly measured the net force and moment that the bicycle, rider and rollers exerted on the floor, enabling calculations of the lateral positions of the system centers of mass and pressure. Balance performance was quantified by cross-correlating the lateral positions of the centers of mass and pressure. The results show that all riders exhibited similar balance performance at the slowest speed. However at higher speeds, the skilled riders achieved superior balance performance by employing more rider lean control (quantified by cross-correlating rider lean angle and bicycle roll angle) and less steer control (quantified by cross-correlating steer rate and bicycle roll rate) than did novice riders. Skilled riders also used smaller steering control input with less variation (measured by average positive steering power and standard deviations of steer angle and rate) and less rider lean angle variation (measured by the standard deviation of the rider lean angle) independent of speed. We conclude that the reduction in balance control input by skilled riders is not due to reduced balance demands but rather to more effective use of lean control to guide the center of mass via center of pressure movements. PMID:26910774

  16. On the Skill of Balancing While Riding a Bicycle.

    Science.gov (United States)

    Cain, Stephen M; Ashton-Miller, James A; Perkins, Noel C

    2016-01-01

    Humans have ridden bicycles for over 200 years, yet there are no continuous measures of how skill differs between novice and expert. To address this knowledge gap, we measured the dynamics of human bicycle riding in 14 subjects, half of whom were skilled and half were novice. Each subject rode an instrumented bicycle on training rollers at speeds ranging from 1 to 7 m/s. Steer angle and rate, steer torque, bicycle speed, and bicycle roll angle and rate were measured and steering power calculated. A force platform beneath the roller assembly measured the net force and moment that the bicycle, rider and rollers exerted on the floor, enabling calculations of the lateral positions of the system centers of mass and pressure. Balance performance was quantified by cross-correlating the lateral positions of the centers of mass and pressure. The results show that all riders exhibited similar balance performance at the slowest speed. However at higher speeds, the skilled riders achieved superior balance performance by employing more rider lean control (quantified by cross-correlating rider lean angle and bicycle roll angle) and less steer control (quantified by cross-correlating steer rate and bicycle roll rate) than did novice riders. Skilled riders also used smaller steering control input with less variation (measured by average positive steering power and standard deviations of steer angle and rate) and less rider lean angle variation (measured by the standard deviation of the rider lean angle) independent of speed. We conclude that the reduction in balance control input by skilled riders is not due to reduced balance demands but rather to more effective use of lean control to guide the center of mass via center of pressure movements.

  17. On the Skill of Balancing While Riding a Bicycle.

    Directory of Open Access Journals (Sweden)

    Stephen M Cain

    Full Text Available Humans have ridden bicycles for over 200 years, yet there are no continuous measures of how skill differs between novice and expert. To address this knowledge gap, we measured the dynamics of human bicycle riding in 14 subjects, half of whom were skilled and half were novice. Each subject rode an instrumented bicycle on training rollers at speeds ranging from 1 to 7 m/s. Steer angle and rate, steer torque, bicycle speed, and bicycle roll angle and rate were measured and steering power calculated. A force platform beneath the roller assembly measured the net force and moment that the bicycle, rider and rollers exerted on the floor, enabling calculations of the lateral positions of the system centers of mass and pressure. Balance performance was quantified by cross-correlating the lateral positions of the centers of mass and pressure. The results show that all riders exhibited similar balance performance at the slowest speed. However at higher speeds, the skilled riders achieved superior balance performance by employing more rider lean control (quantified by cross-correlating rider lean angle and bicycle roll angle and less steer control (quantified by cross-correlating steer rate and bicycle roll rate than did novice riders. Skilled riders also used smaller steering control input with less variation (measured by average positive steering power and standard deviations of steer angle and rate and less rider lean angle variation (measured by the standard deviation of the rider lean angle independent of speed. We conclude that the reduction in balance control input by skilled riders is not due to reduced balance demands but rather to more effective use of lean control to guide the center of mass via center of pressure movements.

  18. Comparative life cycle assessment of ghana-made bamboo-frame bicycle and conventional bicycles assembled and used in the Netherlands

    NARCIS (Netherlands)

    Agyekum, E.O.; Fortuin, K.P.J.; Harst, van der E.J.M.

    2014-01-01

    In order to assess the sustainability of bamboo-framed bicycles produced in Ghana, an environmental and social life cycle assessments (LCA) were performed. For the environmental LCA, a bamboo-frame bicycle was compared with aluminium- and steel-frame bicycles, focussing on processes related to the f

  19. Bicycle helmet use and non-use - recently published research.

    Science.gov (United States)

    Uibel, Stefanie; Müller, Daniel; Klingelhoefer, Doris; Groneberg, David A

    2012-05-25

    Bicycle traumata are very common and especially neurologic complications lead to disability and death in all stages of the life. This review assembles the most recent findings concerning research in the field of bicycle traumata combined with the factor of bicycle helmet use. The area of bicycle trauma research is by nature multidisciplinary and relevant not only for physicians but also for experts with educational, engineering, judicial, rehabilitative or public health functions. Due to this plurality of global publications and special subjects, short time reviews help to detect recent research directions and provide also information from neighbour disciplines for researchers. It can be stated that to date, that although a huge amount of research has been conducted in this area more studies are needed to evaluate and improve special conditions and needs in different regions, ages, nationalities and to create successful prevention programs of severe head and face injuries while cycling.Focus was explicit the bicycle helmet use, wherefore sledding, ski and snowboard studies were excluded and only one study concerning electric bicycles remained due to similar motion structures within this review. The considered studies were all published between January 2010 and August 2011 and were identified via the online databases Medline PubMed and ISI Web of Science.

  20. Test Verification and Design of the Bicycle Frame Parameters

    Institute of Scientific and Technical Information of China (English)

    ZHANG Long; XIANG Zhongxia; LUO Huan; TIAN Guan

    2015-01-01

    Research on design of bicycles is concentrated on mechanism and auto appearance design, however few on matches between the bike and the rider. Since unreasonable human-bike relationship leads to both riders’ worn-out joints and muscle injuries, the design of bicycles should focus on the matching. In order to find the best position of human-bike system, simulation experiments on riding comfort under different riding postures are done with the lifemode software employed to facilitate the cycling process as well as to obtain the best position and the size function of it. With BP neural network and GA, analyzing simulation data, conducting regression analysis of parameters on different heights and bike frames, the equation of best position of human-bike system is gained at last. In addition, after selecting testers, customized bikes based on testers’ height dimensions are produced according to the size function. By analyzing and comparing the experimental data that are collected from testers when riding common bicycles and customized bicycles, it is concluded that customized bicycles are four times even six times as comfortable as common ones. The equation of best position of human-bike system is applied to improve bikes’ function, and the new direction on future design of bicycle frame parameters is presented.

  1. [Bicycle spoke-related injuries in children: emphasise prevention].

    Science.gov (United States)

    Kramer, William L M; Haaring, Gert-Jan

    2011-01-01

    Three children, a 6-year-old boy and two girls aged 5 and 4 years, were seen at an emergency department due to distal lower-leg injuries sustained from the spokes of bicycle wheels. All three patients had been passengers on rear carrying seats of moving bicycles. Only the third bicyclist had used a special child safety seat. The second girl had drawn her foot up from underneath a strap and suffered a tibial fracture later treated with an osteosynthetic plate. The other two patients recovered after conservative casting treatment. Bicycle spoke-related injuries are sustained when the foot or lower limb makes contact with the spokes of a bicycle wheel and usually by children who are bicycle passengers. In the Netherlands, approximately 4600 children are seen at emergency departments with such injuries each year. Bicycle spoke-related accidents can cause severe damage that can result in lengthy recovery periods. Not only physical complications but also psychological ones can occur. The latter are often overlooked but do deserve proper treatment. The physician treating a spoke-related injury is in a good position to advice parents as to preventive measures, particularly on the use of special child safety seats.

  2. Reviving a ghost in the history of technology: the social construction of the recumbent bicycle.

    Science.gov (United States)

    Ahmed, Hassaan; Qureshi, Omer Masood; Khan, Abid Ali

    2015-02-01

    Recumbent bicycles have never truly been associated with international cycling. Conventional safety (upright) bicycles have long been at the center of the cycling world, for both sport and transportation. This is despite the fact that recumbent bicycles are faster, more comfortable, and more efficient than the upright bicycles. The aim of this article is to explain the historical and social perspectives that led to the rejection of the recumbent bicycle by utilizing the theory of Social Construction of Technology (SCOT) and Bijker's two power theory, providing a contrast with the adoption of the safety bicycle.

  3. ROUTE CHOICE MODELLING FOR BICYCLE TRIPS

    Directory of Open Access Journals (Sweden)

    Ehsan Beheshtitabar

    2014-06-01

    Full Text Available This paper intends to find out which parameters have the highest influence on bicyclists’ route-choice-behaviour and how they contribute. There are many attributes considered throughout different studies that are favoured by cyclists. The attributes are the basis for generating a function which predicts the route choice of cyclists. The paper aims at making a comparison between distance-based routes and attribute-based routes. The model for creating the bicycle route choice program is based on the network model of Norrköping, Sweden. The preferred attributes of the model each assign a weight in the cost function of the model for each link of the urban network. The algorithm of the lowest cost function route searches the shortest path in terms of assigned link costs over the whole network. For comparing the results of the cost function and the shortest route (between an origin-destination, the model has a shortest path finding algorithm between different Origin and Destination pairs implemented. It has been viewed that around 25% of all cumulative routes do not show any distance differences between the shortest path distance and attributes based solution. With the used weights of the Standard scenario, it can be seen that the trade-off between shortest distance and safety respectively comfort can be optimized, fulfilling both criteria (distance and safety/comfort.

  4. Bicycle, city and education: search moves

    Directory of Open Access Journals (Sweden)

    Sheila Hempkemeyer

    2016-07-01

    Full Text Available This study comes from a Master’s degree in Education research, which investigates narratives of “pedaling beings” starting from the relationship bicycle-city. The theoretical assumptions lean on the Cultural Studies and concepts about education, culture, everyday life, experience and narratives. Researching with narratives closes everyday life and promotes co-authorship to the subjects in the paper. The article puts in discussion some forms of contemporary subjectivity, resistance techniques and expression. A study that builds narratives and reflections about the experiences of theses hybrid subjects and their everyday life, questioning their way of life in the city. Thinking in this urban medley is connect the environment and the dynamic of these pedaling bodies, emerging other ways of education and interaction with the medium, weaving multiple affectations in aesthetics, poetry, politics, opening breaches to reflect in the everyday happenings. The article also discusses the movements in research and the effects in those who research and are researched.

  5. Built environment influences on healthy transportation choices: bicycling versus driving.

    Science.gov (United States)

    Winters, Meghan; Brauer, Michael; Setton, Eleanor M; Teschke, Kay

    2010-12-01

    A growing body of evidence links the built environment to physical activity levels, health outcomes, and transportation behaviors. However, little of this research has focused on cycling, a sustainable transportation option with great potential for growth in North America. This study examines associations between decisions to bicycle (versus drive) and the built environment, with explicit consideration of three different spatial zones that may be relevant in travel behavior: trip origins, trip destinations, and along the route between. We analyzed 3,280 utilitarian bicycle and car trips in Metro Vancouver, Canada made by 1,902 adults, including both current and potential cyclists. Objective measures were developed for built environment characteristics related to the physical environment, land use patterns, the road network, and bicycle-specific facilities. Multilevel logistic regression was used to model the likelihood that a trip was made by bicycle, adjusting for trip distance and personal demographics. Separate models were constructed for each spatial zone, and a global model examined the relative influence of the three zones. In total, 31% (1,023 out of 3,280) of trips were made by bicycle. Increased odds of bicycling were associated with less hilliness; higher intersection density; less highways and arterials; presence of bicycle signage, traffic calming, and cyclist-activated traffic lights; more neighborhood commercial, educational, and industrial land uses; greater land use mix; and higher population density. Different factors were important within each spatial zone. Overall, the characteristics of routes were more influential than origin or destination characteristics. These findings indicate that the built environment has a significant influence on healthy travel decisions, and spatial context is important. Future research should explicitly consider relevant spatial zones when investigating the relationship between physical activity and urban form.

  6. Modeling the Distribution Characteristics of Urban Public Bicycle Rental Duration

    Directory of Open Access Journals (Sweden)

    Shuichao Zhang

    2016-01-01

    Full Text Available In order to model the distribution characteristics of public bicycle rental durations, individual journey data for three cities in China (Ningbo, Hangzhou, and Beijing, for weekdays, was obtained. The distribution curves for public bicycle rental duration in the three cities were found to be extremely similar, with small differences among the weekdays. The basic parameters such as the average rental duration, the rental duration corresponding to the maximum rental frequency, and the rental duration corresponding to 75% degree were then calculated. On this basis, the radioactive decay law from physics was used to establish a theoretical model for the relationship between rental frequency and rental duration. The data on public bicycle rental duration in Ningbo, Hangzhou, and Beijing were used to test the model and produce a corrected theoretical model. The results indicate that the relationship between rental frequency and rental duration obeys the decay law. The study results provide important theoretical support for the rental station planning of bicycle sharing systems, as well as the allocation, operation, and dispatch of public bicycles.

  7. Bicycling injury hospitalisation rates in Canadian jurisdictions: analyses examining associations with helmet legislation and mode share

    OpenAIRE

    Teschke, Kay; Koehoorn, Mieke; Shen, Hui; Dennis, Jessica

    2015-01-01

    Objectives The purpose of this study was to calculate exposure-based bicycling hospitalisation rates in Canadian jurisdictions with different helmet legislation and bicycling mode shares, and to examine whether the rates were related to these differences. Methods Administrative data on hospital stays for bicycling injuries to 10 body region groups and national survey data on bicycling trips were used to calculate hospitalisation rates. Rates were calculated for 44 sex, age and jurisdiction st...

  8. Investigation with Bluetooth Sensors of Bicycle Travel Time Estimation on a Short Corridor

    OpenAIRE

    Zhenyu Mei; Dianhai Wang; Jun De Chen

    2012-01-01

    Accurate travel time information acquisition is essential to the effective planning and management of bicycle travel conditions. Traditionally, video camera data have been used as the primary source for measuring the quality of bicycle travel time. This paper deals with an investigation of bicycle travel time estimation on a short corridor, using Bluetooth sensors, based on field survey of travel time at one arterial road in Hangzhou. Usually bicycle travel time estimates with Bluetooth senso...

  9. Influences of infrastructure and attitudes to health on value of travel time savings in bicycle journeys

    OpenAIRE

    Björklund, Gunilla; Mortazavi , Reza

    2013-01-01

    In this paper we investigate how attitudes to health and exercise in connection with cycling influence the estimation of values of travel time savings in different kinds of bicycle environments (mixed traffic, bicycle lane in the road way, bicycle path next to the road, and bicycle path not in connection with the road). The results, based on two Swedish stated choice studies, suggest that the values of travel time savings are lower when cycling in better conditions. Surprisingly, the responde...

  10. Predicting Public Bicycle Adoption Using the Technology Acceptance Model

    Directory of Open Access Journals (Sweden)

    Benjamin T. Hazen

    2015-10-01

    Full Text Available Bicycle sharing programs provide a sustainable mode of urban transportation. Although cities across the globe have developed these systems for their citizens and visitors, usage rates are not as high as anticipated. This research uses the technology acceptance model as the basis to understand one’s intention to adopt bicycle sharing programs. Using survey data derived from 421 participants in Beijing, China, the proposed covariance-based structural equation model consisting of perceived quality, perceived convenience, and perceived value is found to predict 50.5% of the variance in adoption intention. The findings of this research contribute to theory and practice in the burgeoning literature on public bicycle systems and sustainable urban transportation by offering a theoretical lens through which to consider system adoption, and providing information to practitioners as to what factors might contribute most to adoption.

  11. Using magnetorheological fluids in an innovative hybrid bicycle damper

    Science.gov (United States)

    Shiao, Y. J.; Nguyen, T. S.

    2015-12-01

    Magnetorheological fluids are capable of changing their viscosity quickly. This can provide good controllability and fast dynamic response. A conventional passive suspension system with air spring or hydraulic damper has simple design and financial benefit for bicycles, but its operation is uncontrollable and non-adaptive. This paper presented a semi-active hybrid bicycle suspension system which combines conventional air spring and a new magnetorheological damping brake together to reduce vibration of a bicycle. A multi-layer magnetorheological brake and linkage mechanism are connected to bike fork to form the adaptive damping part of the innovative hybrid suspension system. The simulation results proved that the semi-active suspension system can reduce bike vibration effectively.

  12. Interventions in Bicycle Infrastructure, Lessons from Dutch and Danish Cases

    DEFF Research Database (Denmark)

    van Goeverden, K.; Nielsen, Thomas Alexander Sick; Harder, Henrik;

    2015-01-01

    Today the interest in cycling is increasing worldwide and in many countries authorities are faced with the question how cycling can be promoted efficiently. In the Netherlands and Denmark, this question came up already in the 1970s when the downsides of the rapidly increasing motorisation became...... evident. At the time, in both countries large scale interventions in bicycle infrastructure were introduced and evaluated extensively in order to create knowledge on efficient promoting of cycling in urban areas. The interventions included the construction of new bicycle routes on urban arterials in some...... was used in both countries for formulating guidelines for road and bicycle infrastructure design. However, at that time the study results were not shared with the international scientific audience. The paper describes briefly the classical cases and the main study results. The outcomes of the classical...

  13. Bicycling crash characteristics: An in-depth crash investigation study.

    Science.gov (United States)

    Beck, Ben; Stevenson, Mark; Newstead, Stuart; Cameron, Peter; Judson, Rodney; Edwards, Elton R; Bucknill, Andrew; Johnson, Marilyn; Gabbe, Belinda

    2016-11-01

    The aim of this study was to describe the crash characteristics and patient outcomes of a sample of patients admitted to hospital following bicycle crashes. Injured cyclists were recruited from the two major trauma services for the state of Victoria, Australia. Enrolled cyclists completed a structured interview, and injury details and patient outcomes were extracted from the Victorian State Trauma Registry (VSTR) and the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR). 186 cyclists consented to participate in the study. Crashes commonly occurred during daylight hours and in clear weather conditions. Two-thirds of crashes occurred on-road (69%) and were a combination of single cyclist-only events (56%) and multi-vehicle crashes (44%). Of the multi-vehicle crashes, a motor vehicle was the most common impact partner (72%) and distinct pre-crash directional interactions were observed between the cyclist and motor vehicle. Nearly a quarter of on-road crashes occurred when the cyclist was in a marked bicycle lane. Of the 31% of crashes that were not on-road, 28 (15%) occurred on bicycle paths and 29 (16%) occurred in other locations. Crashes on bicycle paths commonly occurred on shared bicycle and pedestrian paths (83%) and did not involve another person or vehicle. Other crash locations included mountain bike trails (39%), BMX parks (21%) and footpaths (18%). While differences in impact partners and crash characteristics were observed between crashes occurring on-road, on bicycle paths and in other locations, injury patterns and severity were similar. Most cyclists had returned to work at 6 months post-injury, however only a third of participants reported a complete functional recovery. Further research is required to develop targeted countermeasures to address the risk factors identified in this study. PMID:27544886

  14. Bicycling crash characteristics: An in-depth crash investigation study.

    Science.gov (United States)

    Beck, Ben; Stevenson, Mark; Newstead, Stuart; Cameron, Peter; Judson, Rodney; Edwards, Elton R; Bucknill, Andrew; Johnson, Marilyn; Gabbe, Belinda

    2016-11-01

    The aim of this study was to describe the crash characteristics and patient outcomes of a sample of patients admitted to hospital following bicycle crashes. Injured cyclists were recruited from the two major trauma services for the state of Victoria, Australia. Enrolled cyclists completed a structured interview, and injury details and patient outcomes were extracted from the Victorian State Trauma Registry (VSTR) and the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR). 186 cyclists consented to participate in the study. Crashes commonly occurred during daylight hours and in clear weather conditions. Two-thirds of crashes occurred on-road (69%) and were a combination of single cyclist-only events (56%) and multi-vehicle crashes (44%). Of the multi-vehicle crashes, a motor vehicle was the most common impact partner (72%) and distinct pre-crash directional interactions were observed between the cyclist and motor vehicle. Nearly a quarter of on-road crashes occurred when the cyclist was in a marked bicycle lane. Of the 31% of crashes that were not on-road, 28 (15%) occurred on bicycle paths and 29 (16%) occurred in other locations. Crashes on bicycle paths commonly occurred on shared bicycle and pedestrian paths (83%) and did not involve another person or vehicle. Other crash locations included mountain bike trails (39%), BMX parks (21%) and footpaths (18%). While differences in impact partners and crash characteristics were observed between crashes occurring on-road, on bicycle paths and in other locations, injury patterns and severity were similar. Most cyclists had returned to work at 6 months post-injury, however only a third of participants reported a complete functional recovery. Further research is required to develop targeted countermeasures to address the risk factors identified in this study.

  15. Bicycle Training for Youth with Down Syndrome and Autism Spectrum Disorders

    Science.gov (United States)

    MacDonald, Megan; Esposito, Phil; Hauck, Janet; Jeong, Irully; Hornyak, Joseph; Argento, Angela; Ulrich, Dale A.

    2012-01-01

    Children with Down syndrome (DS) and autism spectrum disorders (ASD) frequently have difficulty riding a two-wheel bicycle. The purpose of this study was to investigate an intervention using an adapted bicycle and individualized instruction to teach 71 youth to ride a standard two-wheel bicycle. Youth with DS (n = 30) and ASD (n = 41) between the…

  16. A City Plans for Bicycles: A Case Study of Olympia, Washington.

    Science.gov (United States)

    Litman, Todd

    1990-01-01

    Discusses community planning for bicycling programs with emphasis on safety education for children and adults, enforcement of bicycle laws, engineering improvements, and special events. Describes how Olympia improved existing bicycling facilities and summarizes planning, communication, engineering, and policy issues addressed. (SV)

  17. Bicycle cycles and mobility patterns - Exploring and characterizing data from a community bicycle program

    CERN Document Server

    Kaltenbrunner, Andreas; Grivolla, Jens; Codina, Joan; Banchs, Rafael

    2008-01-01

    This paper provides an analysis of human mobility data in an urban area using the amount of available bikes in the stations of the community bicycle program Bicing in Barcelona. The data was obtained by periodic mining of a KML-file accessible through the Bicing website. Although in principle very noisy, after some preprocessing and filtering steps the data allows to detect temporal patterns in mobility as well as identify residential, university, business and leisure areas of the city. The results lead to a proposal for an improvement of the bicing website, including a prediction of the number of available bikes in a certain station within the next minutes/hours. Furthermore a model for identifying the most probable routes between stations is briefly sketched.

  18. Experimental and mathematical car-bicycle collision simulations.

    OpenAIRE

    Huybers, J.J.W. & Janssen, E.G.

    1988-01-01

    The results of 35 mathematical simulations will be used to get a better insight in car-bicycle collisions. This information will be used later on to formulate hypotheses to be tested in an accident investigation project. In this paper special attention is given to the influence of the shape of the car and the dimensions of the bicycle/cyclist on the severity of the impacts. It is known that the speed of the car at impact is an important parameter in the resulting injury severity of the cyclis...

  19. Head injuries and bicycle helmet laws.

    Science.gov (United States)

    Robinson, D L

    1996-07-01

    The first year of the mandatory bicycle helmet laws in Australia saw increased helmet wearing from 31% to 75% of cyclists in Victoria and from 31% of children and 26% of adults in New South Wales (NSW) to 76% and 85%. However, the two major surveys using matched before and after samples in Melbourne (Finch et al. 1993; Report No. 45, Monash Univ. Accident Research Centre) and throughout NSW (Smith and Milthorpe 1993; Roads and Traffic Authority) observed reductions in numbers of child cyclists 15 and 2.2 times greater than the increase in numbers of children wearing helmets. This suggests the greatest effect of the helmet law was not to encourage cyclists to wear helmets, but to discourage cycling. In contrast, despite increases to at least 75% helmet wearing, the proportion of head injuries in cyclists admitted or treated at hospital declined by an average of only 13%. The percentage of cyclists with head injuries after collisions with motor vehicles in Victoria declined by more, but the proportion of head injured pedestrians also declined; the two followed a very similar trend. These trends may have been caused by major road safety initiatives introduced at the same time as the helmet law and directed at both speeding and drink-driving. The initiatives seem to have been remarkably effective in reducing road trauma for all road users, perhaps affecting the proportions of victims suffering head injuries as well as total injuries. The benefits of cycling, even without a helmet, have been estimated to outweigh the hazards by a factor of 20 to 1 (Hillman 1993. Cycle helmets-the case for and against. Policy Studies Institute, London). Consequently, a helmet law, whose most notable effect was to reduce cycling, may have generated a net loss of health benefits to the nation. Despite the risk of dying from head injury per hour being similar for unhelmeted cyclists and motor vehicle occupants, cyclists alone have been required to wear head protection. Helmets for motor

  20. An international review of the frequency of single-bicycle crashes (SBCs) and their relation to bicycle modal share

    DEFF Research Database (Denmark)

    Schepers, Paul; Agerholm, Niels; Amoros, Emmanuelle;

    2015-01-01

    . Different countries show a range of values between 5% and 30%. Between 60% and 95% of cyclists admitted to hospitals or treated at emergency departments are victims of SBCs. The proportion of all injured cyclists who are injured in SBCs is unrelated to the share of cycling in the modal split. The share...... of SBC casualties among the total number of road crash casualties increases proportionally less than the increase in bicycle modal share. Conclusions While most fatal injuries among cyclists are due to motor vehicle–bicycle crashes, most hospital admissions and emergency department attendances result...

  1. "Walking" Along a Free Rotating Bicycle Wheel (Round and Round)

    CERN Document Server

    Guemez, Julio

    2016-01-01

    We describe the kinematics, dynamics and also some energetic issues related to the Marta mouse motion when she walks on top of a horizontal bicycle wheel, which is free to rotate like a merry-to-go round, as presented recently by Paul Hewitt in the Figuring Physics section of this magazine.

  2. The safety impact of a yellow bicycle jacket

    DEFF Research Database (Denmark)

    Lahrmann, Harry; Madsen, Tanja Kidholm Osmann

    2016-01-01

    of the project, i.e. after a year. The safety effect of the bicycle jacket was analysed by comparing the number of self-reported accident for the test and control group. The self-reported accidents showed that the test group had 38 % fewer personal injury accidents with other road users – so-called multi...

  3. Consumers’ preferences for “bicycle poultry” in Benin

    DEFF Research Database (Denmark)

    Sodjinou, Epiphane; Henningsen, Arne; Koudande, Delphin O.;

    2015-01-01

    Village poultry, also termed "bicycle poultry," is produced in scavenging farming systems and is a chewy meat with a low fat content, and constitutes an important source of meat in many African countries. This study investigates consumers’ preferences regarding the physical traits of these birds ...

  4. Mapping Bicycle Crash Risk Patterns on the Local Scale

    Directory of Open Access Journals (Sweden)

    Martin Loidl

    2016-09-01

    Full Text Available Currently, mainly aggregated statistics are used for bicycle crash risk calculations. Thus, the understanding of spatial patterns at local scale levels remains vague. Using an agent-based flow model and a bicycle crash database covering 10 continuous years of observation allows us to calculate and map the crash risk on various spatial scales for the city of Salzburg (Austria. In doing so, we directly account for the spatial heterogeneity of crash occurrences. Additionally, we provide a measure for the statistical robustness on the level of single reference units and consider modifiable areal unit problem (MAUP effects in our analysis. This study is the first of its kind. The results facilitate a better understanding of spatial patterns of bicycle crash rates on the local scale. This is especially important for cities that strive to improve the safety situation for bicyclists in order to address prevailing safety concerns that keep people from using the bicycle as a utilitarian mode of (urban transport.

  5. Utilizing the Bicycle for Non-Traditional Activities

    Science.gov (United States)

    Maina, Michael P.; Maina, Julie Schlegel; Sebek, Ludek; Hoffmanova, Jana; Kane, Jennifer Jackson

    2012-01-01

    This article examines the bicycle as not simply a means of transportation or as an exercise device, but rather as a vehicle for teambuilding and problem solving activities within a physical education curriculum. The activities described in this article focus on bike-centered initiatives that foster creative problem solving. They have universal…

  6. Bicyclic graphs with exactly two main signless Laplacian eigenvalues

    CERN Document Server

    Huang, He

    2012-01-01

    A signless Laplacian eigenvalue of a graph $G$ is called a main signless Laplacian eigenvalue if it has an eigenvector the sum of whose entries is not equal to zero. In this paper, all connected bicyclic graphs with exactly two main eigenvalues are determined.

  7. 77 FR 39927 - Vehicles and Traffic Safety-Bicycles

    Science.gov (United States)

    2012-07-06

    ... family--they bicycle to visit points of interest, to be healthy, and because it's fun. The National Park... that, at a minimum, the plan: Evaluates the suitability of existing trail surface and soil condition... objectives and will not disturb wildlife or park resources. See NPS Management Policies 2006,...

  8. Experimental and mathematical car-bicycle collision simulations.

    NARCIS (Netherlands)

    Huybers, J.J.W. & Janssen, E.G.

    1988-01-01

    The results of 35 mathematical simulations will be used to get a better insight in car-bicycle collisions. This information will be used later on to formulate hypotheses to be tested in an accident investigation project. In this paper special attention is given to the influence of the shape of the

  9. Bicyclic peptide inhibitor of urokinase-type plasminogen activator

    DEFF Research Database (Denmark)

    Roodbeen, Renée; Jensen, Berit Paaske; Jiang, Longguang;

    2013-01-01

    The development of protease inhibitors for pharmacological intervention has taken a new turn with the use of peptide-based inhibitors. Here, we report the rational design of bicyclic peptide inhibitors of the serine protease urokinase-type plasminogen activator (uPA), based on the established...

  10. Bicycle sharing system: role, effects and application to Plymouth

    OpenAIRE

    Wiersma, Bouke

    2010-01-01

    Abstract This thesis investigates the role and effects of a bicycle sharing system, and studies the feasi-bility of such a system in Plymouth. The research consists of a literature review, policy dis-cussion, case studies, and a detailed assessment of t

  11. Expedition Paris-Beijing by Bicycle 2008 Launched

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>From March 15 to17, at the invitation of the Euro-Chinese Friendship Association (ECFA) of France, a CPAFFC representative attended the launching ceremony of the Expedition Paris-Beijing by Bicycle 2008 in Paris, during which he met with officials of the National Commission on Decentralized Cooperation (Commission Nationale de la Cooperation Decentralisee-CNCD) of France.

  12. Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids

    DEFF Research Database (Denmark)

    Conti, Paola; De Amici, Marco; Joppolo Di Ventimiglia, Samuele;

    2003-01-01

    Bicyclic acidic amino acids (+/-)-6 and (+/-)-7, which are conformationally constrained homologues of glutamic acid, were prepared via a strategy based on a 1,3-dipolar cycloaddition. The new amino acids were tested toward ionotropic and metabotropic glutamate receptor subtypes; both of them...

  13. Efficiency of choice set generation methods for bicycle routes

    DEFF Research Database (Denmark)

    Halldórsdóttir, Katrín; Rieser-Schussler, Nadine; Axhausen, Kay W.;

    2014-01-01

    for scenic routes, dedicated cycle lanes, and road type. Data consisted of 778 bicycle trips traced by GPS and carried out by 139 persons living in the Greater Copenhagen Area, in Denmark. Results suggest that both the breadth first search on link elimination and the doubly stochastic generation function...

  14. Use and activity levels on newly built bicycle playgrounds

    DEFF Research Database (Denmark)

    Schipperijn, Jasper; Hansen, Christine Kier; Rask, Simon

    2015-01-01

    Increasing the use of urban green space (UGS) as well as increasing cycling could potentially help address the growing inactivity problem. Three bicycle playgrounds were designed based on a participatory process and afterwards constructed in the UGS along a cycle-route on the historic outer defen...

  15. A Formal Synthesis of ( + )-Cassiol Exploiting Meyers' Bicyclic Lactam Methodology

    Institute of Scientific and Technical Information of China (English)

    SHEN,Xin(沈鑫); WU,Yi-Kang(伍贻康); ZHANG,Fan(张帆)

    2002-01-01

    A formal synthesis of ( + )-cassiol using (1S,2S)-2-amino-1-(4- nitrophenyl)-1,3-propanediol as chiral auxiliary is reported.The quaternary chiral center in the molecule was constructed by sequential alkylation of a bicyclic lactam (prepared from the aforementioned auxiliary and 5-oxo-heptanlic acid) with methyl iodide and benzyloxymethyl chloride.

  16. Bicycle Conversion Factor Calibration at Two-Phase Intersections in Mixed Traffic Flows

    Institute of Scientific and Technical Information of China (English)

    WANG Dianhai; LIANG Chunyan; JING Chunguang; WANG Guohua

    2007-01-01

    Chinese traffic is typically composed of bicycles and motor vehicles on the same road. The efficiency of bicycle traffic in time and space at intersections was investigated for eight typical intersections in the cities of Tianjin, Shenyang, and Changchun, all in China, by means of video recording. Models were developed to calculate the through bicycle traffic and the left-turn bicycle traffic conversion factors in intersections where bicycles and motor vehicles share the same road. The results indicate that the through bicycle conversion factor is 0.28 and the left-turn bicycle conversion factor is 0.33. This conclusion differs from the current value used in China. More research on the conversion factor is necessary to evaluate the impact of intersections.

  17. Bicycle injuries: a matter of mechanism and age.

    Science.gov (United States)

    Siman-Tov, Maya; Jaffe, Dena H; Peleg, Kobi

    2012-01-01

    Bicycle riding is a popular form of recreation with positive health and environmental effects. These road users are vulnerable to serious injuries, especially when motor vehicles are involved. The goal of this study was to characterize cyclist-related injuries according to motor vehicle involvement for adults versus children. A retrospective study was carried out using data from 11 trauma centers in the Israeli National Trauma Registry (2001-2007). Injuries were classified according to whether a motor vehicle was involved, and differences in injury characteristics were assessed for adults (18+ years) versus children (1-17 years). A total of 5529 patients were hospitalized for bicycle injuries, of whom 1765 were adults and 3764 were children. Thirty percent (n=1662) of all bicycle injuries involved motor vehicles, although the rate of injuries resulting in hospitalization was 37% among adults and 27% among children. Injury characteristics and hospital resource utilization differed substantially by age group. Cyclists struck by a motor vehicle presented with more severe injuries requiring more hospital resources and resulting in poorer outcomes than those not involved with motor vehicles. The interaction effect between motor vehicle involvement and age was significant for torso injuries and need for medical imaging. We found that injury characteristics, hospital resource utilization and health-related outcomes for bicycle injuries are highly dependent on patient's age and mechanism of injury. Effect modification of motor vehicle involvement by age may in part reflect physicians' attitudes toward pediatric imaging. The risks identified in this study should be used for preparedness and management of trauma hospitalizations from bicycle injuries. PMID:22062347

  18. Chest Traumas due to Bicycle accident in Childhood

    Directory of Open Access Journals (Sweden)

    Ufuk Cobanoglu

    2011-09-01

    Full Text Available Aim:Childhood injuries are the leading cause of death in children and result in significant healthcare utilization. Trauma is the second most common cause of mortality in children aged 1-4 years and leading cause of death in children older than 4 years. Thoracic injury is the second most leading cause of death in traumatized children. Multisystemic injury is found in more than 50% of children with thoracic injuries most of which are secondary to blunt traumas. We planned this study to evaluate thorax trauma cases secondary to bicycle driving in childhood and to draw attention to the importance of the regulation of traffic rules, the education of bicycle drivers.Material and Methods:  A retrospective evaluation was performed in 17 pediatric patients admitted to the Department of Thoracic Surgery during 2006-2010 with a diagnosis of chest trauma due to bicycle driving. For every patient, a pediatric trauma score (PTS was calculated. Descriptive statistics were performed for PTS. Results; Eleven (64.70% cases were injured due to the tricycle accidents and six cases 6 (35.29% were injured due to the two-wheeled bicycle accidents. The most frequent thoracic pathologies included pulmonary contusion (41.2% and chest wall contusion (29.41%. Extrathoracic injuries were seen in 35.29%, the extremities (17.64% and abdomino pelvic (11.76% being the most commonly involved. Treatment consisted of symptomatic treatment in 12 patients (70.58%, tube thoracostomy in 2 patients (11.76%, and thoracotomy in 1 patient (5.9%. The morbidity was seen in 3 patients (17.64%. The mortality rate was 5.9% (n:1. The mean PTS of the cases who had additional system injuries were significantly worse than the cases who had isolated chest traumas Conclusions: The pediatric thorax has a greater cartilage content and incomplete ossification of the ribs. Due to the pliability of the pediatric rib cage and mediastinal mobility, significant intrathoracic injury may exist in the

  19. Personal and behavioral factors associated with bicycling in adults from Curitiba, Parana State, Brazil

    Directory of Open Access Journals (Sweden)

    Marilson Kienteka

    2014-01-01

    Full Text Available Bicycling is an important form of physical activity that can promote health benefits. The objective of this study was to analyze the association between personal and behavioral aspects in transportation bicycling and leisure time bicycling in adults. Data was drawn from a household survey involving 677 adults (53.1% female in Curitiba, Paraná State, Brazil. The prevalence of bicycling was 11.2% for transportation and 16.7% for leisure. The frequency of leisure time bicycling was higher among men (PR = 2.08; p < 0.001, young people < 30 and adults aged between 30 and 39.9, bicycle owners (PR = 8.76; p < 0.001 and among the physically active. Transportation bicycling occurred more frequently among men (PR = 3.63; p < 0.001, individuals aged 30 to 39.9, those with a low socioeconomic status (PR = 5.00; p = 0.006, bicycle owners (PR = 10.2; p < 0.001 and individuals with a negative perception of their quality of life. The prevalence of bicycling is low in Curitiba considering its potential as a means of physical activity. Personal and behavioral factors were associated with each form of bicycling.

  20. The fastest bicycle in the world; how a team of Delft students is building a bicycle to break the world speed record

    NARCIS (Netherlands)

    Annega, G.

    2011-01-01

    The Netherlands is a country known for its extensive use of bicycles as a means of everyday transport. However, while it has existed for about two centuries, todays bicycles only differ from those of the 19th century in relatively small details. Human Power Team Delft is building a whole new type of

  1. Efficiency of Choice Set Generation Methods for Bicycle Routes

    DEFF Research Database (Denmark)

    Halldórsdóttir, Katrín; Rieser-Schüssler, Nadine; W. Axhausen, Kay;

    With a growing interest in sustainable transport systems, the interest has increased on encouraging more cycling. To encourage cycling, it is important to identify which network attributes influence cyclists route choice and evaluate the trade-offs among these attributes. To analyse travel...... behaviour, observed choices and alternatives composing the choice set of each cyclist are necessary. However, generating the alternative choice sets can prove challenging. This paper analyses the efficiency of various choice set generation methods for bicycle routes in order to contribute to our...... that might produce inconsistent estimates. There have been some studies on bicycle route choice set generation reported in the literature, whereof few studies focussed on route choice models for bicyclist estimated from GPS observations. Menghini et al. [3] successfully applied a Breadth First Search on Link...

  2. Simultaneous optimization of transit network and public bicycle station network

    Institute of Scientific and Technical Information of China (English)

    刘洋; 朱宁; 马寿峰

    2015-01-01

    The traditional manner to design public transportation system is to sequentially design the transit network and public bicycle network. A new public transportation system design problem that simultaneously considers both bus network design and public bicycle network design is proposed. The chemical reaction optimization (CRO) is designed to solve the problem. A shortcoming of CRO is that, when the two-molecule collisions take place, the molecules are randomly picked from the container. Hence, we improve CRO by employing different mating strategies. The computational results confirm the benefits of the mating strategies. Numerical experiments are conducted on the Sioux-Falls network. A comparison with the traditional sequential modeling framework indicates that the proposed approach has a better performance and is more robust. The practical applicability of the approach is proved by employing a real size network.

  3. [Electrically assisted bicycles: health enhancement or "green" gadget?].

    Science.gov (United States)

    Welker, J; Cornuz, J; Gojanovic, B

    2012-07-25

    Electrically assisted bicycles (EAB) are flourishing in cities throughout the world and capitalize on ecological and practical advantages, helping in the fight against pollution, CO2 emissions and traffic jam. Human power is necessary to activate the electrical support, so that it equals to a moderate intensity physical activity (> 3 MET), or a vigorous one on hilly courses (>6 MET). The ecological benefits are obvious and transportation departments tend to support citizens who purchase one. EAB offer increased mobility at speeds of 15 to 25 km/h depending on hills and fitness of the rider, but could cause more accidents. EAB is linked to a real physical activity beneficial for health, but potentially more dangerous than a traditional bicycle. PMID:22913003

  4. A system for quantifying the cooling effectiveness of bicycle helmets.

    Science.gov (United States)

    Reid, J; Wang, E L

    2000-08-01

    This article describes the design and development of a system that is capable of quantifying the thermal comfort of bicycle helmets. The motivation for the development of the system stems from the desire both to increase helmet use and to provide the designer with a quantitative method of evaluating the thermal comfort of a helmet. The system consists of a heated mannequin head form, a heated reference sphere, a small wind tunnel, and a data acquisition system. Both the head form and the reference sphere were instrumented with thermocouples. The system is capable of simulating riding speeds ranging from 4.5-15.5 m/s. A cooling effectiveness, C1, that is independent of both ambient conditions and wind velocity is defined as a measure of how well the helmet ventilates as compared to the reference sphere. The system was validated by testing six commercially available bicycle helmets manufactured between approximately 1992 and 1998. PMID:11036573

  5. Cellular automata simulation of traffic including cars and bicycles

    Science.gov (United States)

    Vasic, Jelena; Ruskin, Heather J.

    2012-04-01

    As 'greening' of all aspects of human activity becomes mainstream, transportation science is also increasingly focused around sustainability. Modal co-existence between motorised and non-motorised traffic on urban networks is, in this context, of particular interest for traffic flow modelling. The main modelling problems here are posed by the heterogeneity of vehicles, including size and dynamics, and by the complex interactions at intersections. Herein we address these with a novel technique, based on one-dimensional cellular automata components, for modelling network infrastructure and its occupancy by vehicles. We use this modelling approach, together with a corresponding vehicle behaviour model, to simulate combined car and bicycle traffic for two elemental scenarios-examples of components that would be used in the building of an arbitrary network. Results of simulations performed on these scenarios, (i) a stretch of road and (ii) an intersection causing conflict between cars and bicycles sharing a lane, are presented and analysed.

  6. Optimization of electric bicycle for youths with disabilities

    OpenAIRE

    Blumenstein, Tobias; Zeitlmann, Hilar; Alves-Pinto, Ana; Turova, Varvara; Lampe, Renée

    2014-01-01

    Cerebral palsy is a group of neurodevelopmental disorders that affect a person’s ability to move and to maintain balance and posture. People with cerebral palsy have also perception and space orientation deficits so that special assistance devices should be developed to compensate these handicaps. The objective was to optimize an adapted electric bicycle (E-bike) for youths with neurodevelopmental disorders. An adapted E-bike was provided with ultrasonic sensors that measure distances to obje...

  7. Interventions in Bicycle Infrastructure, Lessons from Dutch and Danish Cases

    OpenAIRE

    Van Goeverden, K.; Nielsen, Thomas Alexander Sick; Harder, Henrik; van Nes, Rob

    2015-01-01

    Today the interest in cycling is increasing worldwide and in many countries authorities are faced with the question how cycling can be promoted efficiently. In the Netherlands and Denmark, this question came up already in the 1970s when the downsides of the rapidly increasing motorisation became evident. At the time, in both countries large scale interventions in bicycle infrastructure were introduced and evaluated extensively in order to create knowledge on efficient promoting of cycling in ...

  8. Methodology for a global bicycle real world accidents reconstruction

    OpenAIRE

    Bourdet, Nicolas; Deck, Caroline; Serre, Thierry; Perrin, Christophe; LLARI, Maxime; Willinger, Rémy

    2012-01-01

    The use of the bicycle on a large scale encouraged in the context to develop an eco friendly environment is facing today on a range of barriers. One of these barriers identified by researchers and governments is observed to include ‘road safety’. Hence, it is necessary to set up a protection system for bicyclists especially for the cephalic segment. Currently only few studies are available concerning the head impact loading in case of real accidents. Therefore, the objective of th...

  9. In-depth real-world bicycle accident reconstructions

    OpenAIRE

    Bourdet, Nicolas; Deck, Caroline; Serre, Thierry; Perrin, Christophe; LLARI, Maxime; Willinger, Rémy

    2013-01-01

    Use of bicycles on a large scale, encouraged in the context to develop an eco-friendly environment, is facing today a range of barriers. One of these barriers identified by researchers and governments is observed to include ‘road safety’. Hence, it is necessary to set up a protection system for bicyclists especially for the cephalic segment. Currently only few studies are available concerning the head impact loading in case of real accidents. Therefore, the objective of this work ...

  10. Mobile cockpit system for enhanced electric bicycle use

    OpenAIRE

    João C. Ferreira; Monteiro, Vítor Duarte Fernandes; Afonso, José A.; Afonso, João L.

    2015-01-01

    This paper presents the project of a Mobile Cockpit System (MCS) for smartphones, which provides assistance to Electric Bicycle (EB) cyclists in Smart Cities’ environment. The presented system introduces a mobile application (MCS App) with the goal to provide useful personalized information to the cyclist related with the EB’s use, including EB range prediction considering the intended path, management of the cycling effort performed by the cyclist, handling of the battery charging process an...

  11. The value of time and external benefits in bicycle appraisal

    OpenAIRE

    Börjesson, Maria; ELIASSON, Jonas

    2011-01-01

    We estimate the value of time savings, different cycling environments and additional benefits in cost-benefit analysis of cycling investments. Cyclists’ value of travel time savings turns out to be high, considerably higher than the value of time savings on alternative modes. Cyclists also value other improvements highly, such as separated bicycle lanes. As to additional benefits of cycling improvements in the form of health and reduced car traffic, our results do not support the notion that ...

  12. Harvesting Energy from the Counterbalancing (Weaving) Movement in Bicycle Riding

    OpenAIRE

    Shashank Priya; Jeongjin Yeo; Yoonseok Yang

    2012-01-01

    Bicycles are known to be rich source of kinetic energy, some of which is available for harvesting during speedy and balanced maneuvers by the user. A conventional dynamo attached to the rim can generate a large amount of output power at an expense of extra energy input from the user. However, when applying energy conversion technology to human powered equipments, it is important to minimize the increase in extra muscular activity and to maximize the efficiency of human movements. This study p...

  13. Finite element analysis of advanced bicycle precision brake disk forming technology

    Directory of Open Access Journals (Sweden)

    Chen Dyi-Cheng

    2015-01-01

    Full Text Available In recent years, the bicycle has become an environmentally friendly transportation. The bicycle can be divided into mountain bicycle and highway bicycle. Safe driving is the prior consideration. The bicycle braking system can be divided into oil pressure disk brakes and mechanical disk brakes. The brake disk system is one indispensable component of the safe system. In accordance to overall weight consideration of the bike, the brake disk should also focus on the lightweight design. This paper discussed an innovative brake disk forming technology for 6061 aluminum alloy by the rigid-plastic finite element analysis. The simulation parameters include geometric shapes of the brake disk and mold, die temperature, and friction factors. The stress and strain in forming, brake deformation and vibration modal analysis of brake disk in riding were studied. The paper is expected to offer some precision bicycle brake disk manufacture knowledge for industry.

  14. Harvesting Energy from the Counterbalancing (Weaving) Movement in Bicycle Riding

    Science.gov (United States)

    Yang, Yoonseok; Yeo, Jeongjin; Priya, Shashank

    2012-01-01

    Bicycles are known to be rich source of kinetic energy, some of which is available for harvesting during speedy and balanced maneuvers by the user. A conventional dynamo attached to the rim can generate a large amount of output power at an expense of extra energy input from the user. However, when applying energy conversion technology to human powered equipments, it is important to minimize the increase in extra muscular activity and to maximize the efficiency of human movements. This study proposes a novel energy harvesting methodology that utilizes lateral oscillation of bicycle frame (weaving) caused by user weight shifting movements in order to increase the pedaling force in uphill riding or during quick speed-up. Based on the 3D motion analysis, we designed and implemented the prototype of an electro-dynamic energy harvester that can be mounted on the bicycle's handlebar to collect energy from the side-to-side movement. The harvester was found to generate substantial electric output power of 6.6 mW from normal road riding. It was able to generate power even during uphill riding which has never been shown with other approaches. Moreover, harvesting of energy from weaving motion seems to increase the economy of cycling by helping efficient usage of human power. PMID:23112598

  15. Electric motor assisted bicycle as an aerobic exercise machine.

    Science.gov (United States)

    Nagata, T; Okada, S; Makikawa, M

    2012-01-01

    The goal of this study is to maintain a continuous level of exercise intensity around the aerobic threshold (AT) during riding on an electric motor assisted bicycle using a new control system of electrical motor assistance which uses the efficient pedaling rate of popular bicycles. Five male subjects participated in the experiment, and the oxygen uptake was measured during cycling exercise using this new pedaling rate control system of electrical motor assistance, which could maintain the pedaling rate within a specific range, similar to that in previous type of electrically assisted bicycles. Results showed that this new pedaling rate control system at 65 rpm ensured continuous aerobic exercise intensity around the AT in two subjects, and this intensity level was higher than that observed in previous type. However, certain subjects were unable to maintain the expected exercise intensity because of their particular cycling preferences such as the pedaling rate. It is necessary to adjust the specific pedaling rate range of the electrical motor assist control according to the preferred pedaling rate, so that this system becomes applicable to anyone who want continuous aerobic exercise.

  16. Harvesting energy from the counterbalancing (weaving) movement in bicycle riding.

    Science.gov (United States)

    Yang, Yoonseok; Yeo, Jeongjin; Priya, Shashank

    2012-01-01

    Bicycles are known to be rich source of kinetic energy, some of which is available for harvesting during speedy and balanced maneuvers by the user. A conventional dynamo attached to the rim can generate a large amount of output power at an expense of extra energy input from the user. However, when applying energy conversion technology to human powered equipments, it is important to minimize the increase in extra muscular activity and to maximize the efficiency of human movements. This study proposes a novel energy harvesting methodology that utilizes lateral oscillation of bicycle frame (weaving) caused by user weight shifting movements in order to increase the pedaling force in uphill riding or during quick speed-up. Based on the 3D motion analysis, we designed and implemented the prototype of an electro-dynamic energy harvester that can be mounted on the bicycle's handlebar to collect energy from the side-to-side movement. The harvester was found to generate substantial electric output power of 6.6 mW from normal road riding. It was able to generate power even during uphill riding which has never been shown with other approaches. Moreover, harvesting of energy from weaving motion seems to increase the economy of cycling by helping efficient usage of human power.

  17. Electric motor assisted bicycle as an aerobic exercise machine.

    Science.gov (United States)

    Nagata, T; Okada, S; Makikawa, M

    2012-01-01

    The goal of this study is to maintain a continuous level of exercise intensity around the aerobic threshold (AT) during riding on an electric motor assisted bicycle using a new control system of electrical motor assistance which uses the efficient pedaling rate of popular bicycles. Five male subjects participated in the experiment, and the oxygen uptake was measured during cycling exercise using this new pedaling rate control system of electrical motor assistance, which could maintain the pedaling rate within a specific range, similar to that in previous type of electrically assisted bicycles. Results showed that this new pedaling rate control system at 65 rpm ensured continuous aerobic exercise intensity around the AT in two subjects, and this intensity level was higher than that observed in previous type. However, certain subjects were unable to maintain the expected exercise intensity because of their particular cycling preferences such as the pedaling rate. It is necessary to adjust the specific pedaling rate range of the electrical motor assist control according to the preferred pedaling rate, so that this system becomes applicable to anyone who want continuous aerobic exercise. PMID:23366293

  18. [Mortality due to bicycle accidents in Pernambuco, Brazil].

    Science.gov (United States)

    Galvão, Pauliana Valéria Machado; Pestana, Luciana Pinto; Pestana, Valter Mário; Spíndola, Michelline Oliveira Pedrosa; Campello, Reginaldo Inojosa Carneiro; de Souza, Eliane Helena Alvim

    2013-05-01

    The scope of this paper was to conduct a quantitative analysis of deaths resulting from bicycle accidents in the state of Pernambuco by studying secondary data between 2001 and 2010. The sample consisted of all the Deaths recorded in the Mortality Information System of the Unified Health System Database that reported bicycle accidents between 2001 and 2010. Descriptive measures were determined for all variables. Socio-demographic variables were paired with the basic cause of death in order to find a statistical correlation. In Pernambuco, the aforementioned information system recorded 517 deaths resulting from bicycle accidents, with greater frequency in men between 25 and 59 years of age, Afro-Brazilians, single and of unknown schooling. The mean age was 36.82 years (SD = 17.026), and the minimum and maximum age of 4 and 86 years old, respectively. The findings highlight the need for the creation of adequate infrastructure and effective legal measures to prevent traffic accidents involving this type of vehicle, relying on the evidence of distribution of cases in most Pernambuco municipalities.

  19. Design Analysis And Applications Of A Regenerative Bicycle Ergometer

    Directory of Open Access Journals (Sweden)

    Chukwuneke J. L.

    2015-08-01

    Full Text Available Man needs to do some form of physical work in other to remain healthy this work is similar to the work done by any machine or equipment and thus should be channeled to give useful output but rather it is usually dissipated into the environment in form of heat. The regenerative bicycle ergometer takes advantage of the greater power generated by the limbs and arms thus conserves converts and stores the energy dissipated by the rider with an ideal mechanical advantage of 7.6 it strategically uses simple mechanisms to magnify its work and then converts this mechanical energy into electrical energy by the use of a dynamo with a speed ratio of 108.5 and a transmission efficiency of 89 the rider pedals 27rpm to obtain the dynamos rated input of 2600rpm giving an output of 12.6volts. The regenerative bicycle ergometer is designed and constructed to perform all the core functions of a bicycle ergometer having an allowable load of 116.5kg and a maximum resistance of 65.33N which is equivalent to a mass of 6.66kg. The energy converted is stored in a 12volts battery making its use flexible clean and meeting the energy demands of man.

  20. Conversion Of An Ordinary N Bicycle Into An Electric Bike And Related Research

    OpenAIRE

    Marius Janavičius

    2014-01-01

    An electric bicycle as a transport and leisure vehicle is expected to have a promising future. Currently, he market offers a great choice of factory electric bicycles and conversion kits to remake an ordinary bicycle into an electric bike. Also, the increasing number of electric vehicles is determined by the reduction in costs for manufacturing of batteries and an evolution in battery technology. This article presents the implementation of an electric bike by selecting the “Golden Motor Techn...

  1. A Modified Cellular Automaton Approach for Mixed Bicycle Traffic Flow Modeling

    OpenAIRE

    Xiaonian Shan; Zhibin Li; Xiaohong Chen; Jianhong Ye

    2015-01-01

    Several previous studies have used the Cellular Automaton (CA) for the modeling of bicycle traffic flow. However, previous CA models have several limitations, resulting in differences between the simulated and the observed traffic flow features. The primary objective of this study is to propose a modified CA model for simulating the characteristics of mixed bicycle traffic flow. Field data were collected on physically separated bicycle path in Shanghai, China, and were used to calibrate the C...

  2. "The Mechanisms. Light and Miraculous": The Convivial Bicycle in Literature and Film

    OpenAIRE

    Guevara, J. Josh

    2012-01-01

    This dissertation explores the prevalent representation of the bicycle as a liberatory figure in theoretical texts, novels, films, and poetry. Because the bicycle confers unexpected creativity and autonomy, it alters definitions of technology, modernity, and identity. Chapter one recuperates and employs Ivan Illich's concept of conviviality in order to re-examine the inheritance of the project of modernity and question the definition of technology in the twenty-first century bicycle epoch. Fo...

  3. Automated Analysis Methods for the Assessment of Bicycle Infrastructure and Demand

    OpenAIRE

    Pashkevich, Anton

    2013-01-01

    A first phase of the research activity has been related to the study of the state of art of the infrastructures for cycling, bicycle use and methods for evaluation. In this part, the candidate has studied the "bicycle system" in countries with high bicycle use and in particular in the Netherlands. Has been carried out an evaluation of the questionnaires of the survey conducted within the European project BICY on mobility in general in 13 cities of the participating countries. The questionn...

  4. Development of New Chiral Bicyclic Ligands : Applications in Catalytic Asymmetric Transfer Hydrogenation, Epoxidations, and Epoxide Rearrangements

    OpenAIRE

    Gayet, Arnaud

    2005-01-01

    This thesis describes the synthesis and application of new chiral bicyclic ligands and their application in asymmetric catalysis. The studies involved: [i] The development of novel chiral bicyclic amino sulfur ligands and their use in transfer hydrogenation. [ii] The development of the kinetic resolution of racemic epoxide through the use of chiral lithium amides. [iii] The synthesis and application of chiral bicyclic amine in the organocatalysed epoxidation of alkenes. [iv] Development and a...

  5. Compositions comprising a polypeptide having cellulolytic enhancing activity and a bicyclic compound and uses thereof

    Energy Technology Data Exchange (ETDEWEB)

    Quinlan, Jason; Xu, Feng; Sweeney, Matthew

    2016-10-04

    The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a bicyclic compound. The present invention also relates to methods of using the compositions.

  6. Compositions comprising a polypeptide having cellulolytic enhancing activity and a bicycle compound and uses thereof

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Feng; Sweeney, Matthew; Quinlan, Jason

    2015-06-16

    The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a bicyclic compound. The present invention also relates to methods of using the compositions.

  7. Thermoregulation during prolonged actual and laboratory-simulated bicycling.

    Science.gov (United States)

    Brown, S L; Banister, E W

    1985-01-01

    Thermoregulatory and cardiorespiratory responses to bicycling 55 km (mean speed 9.7 m X s-1) outdoors (15 degrees C DB) were compared to equivalent cycle ergometry (90 min at 65% VO2max) in the laboratory (20-23 degrees C DB, 50% RH) in 7 trained cyclists. Outdoor environmental conditions were simulated with fans and lamps, and were contrasted with standard no-wind, no-sun laboratory conditions. Sweating rate was similar during outdoor and laboratory simulated outdoor cycling (0.90 and 0.87 to 0.94 1 X h-1 respectively). During outdoor bicycling, mean heart rate (161 bt X min-1) was 7-13% higher (p less than .05) than under laboratory conditions, suggesting a greater strain for a similar external work rate. The increase in rectal temperature (0.8 degrees C) was 33-50% less (p less than 0.05) at the cooler outdoor ambient temperature than in the laboratory. Thermoregulatory stress was greater under the no-fan, no-lamp laboratory condition than during simulated outdoor conditions (36-38% greater (p less than 0.05) sweating rate, 15-18% greater (p less than 0.01) mean skin temperature, 6.4 to 7.8 fold greater (p less than 0.01) amount of clothing-retrained sweat). The cooling wind encountered in actual road bicycling apparently reduces thermoregulatory and circulatory demands compared with stationary cycle ergometry indoors. Failure to account for this enhanced cooling may result in overestimation of the physiological stress of actual road cycling.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Safety effects of permanent running lights for bicycles: A controlled experiment.

    Science.gov (United States)

    Madsen, J C O; Andersen, T; Lahrmann, H S

    2013-01-01

    Making the use of daytime running lights mandatory for motor vehicles is generally documented to have had a positive impact upon traffic safety. Improving traffic safety for bicyclists is a focal point in the road traffic safety work in Denmark. In 2004 and 2005 a controlled experiment including 3845 cyclists was carried out in Odense, Denmark in order to examine, if permanent running lights mounted to bicycles would improve traffic safety for cyclists. The permanent running lights were mounted to 1845 bicycles and the accident rate was recorded through 12 months for this treatment group and 2000 other bicyclists, the latter serving as a control group without bicycle running lights. The safety effect of the running lights is analysed by comparing incidence rates - number of bicycle accidents recorded per man-month - for the treatment group and the control group. The incidence rate, including all recorded bicycle accidents with personal injury to the participating cyclist, is 19% lower for cyclists with permanent running lights mounted; indicating that the permanent bicycle running light significantly improves traffic safety for cyclists. The study shows that use of permanent bicycle running lights reduces the occurrence of multiparty accidents involving cyclists significantly. In the study the bicycle accidents were recorded trough self-reporting on the Internet. Possible shortcomings and problems related to this accident recording are discussed and analysed. PMID:22884376

  9. Advocating Green Transport and Promoting Healthy Urban Development: Strategies for Bicycle Transport Development in Jinan

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>As a green transport means,the bicycle has a history of over two hundred years.Since the 1970s,due to the inf luence of energy crisis and the consciousness of environment protection,the bicycle has regained its popularity in the public for its

  10. Use of Adapted Bicycles on the Learning of Conventional Cycling by Children with Mental Retardation

    Science.gov (United States)

    Burt, Tammy L.; Porretta, David L.; Klein, Richard E.

    2007-01-01

    This study investigated the use of adapted bicycles on the acquisition, maintenance, and generalization of conventional cycling by seven children with mild mental retardation. Feedback was used in addition to the adapted bicycles and consisted of pedal rate, head position, and steering participation. A multiple probe design was used. Participants…

  11. 16 CFR Figure 8 to Part 1512 - Reflectorized Bicycle Wheel Rim Abrasion Test Device

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reflectorized Bicycle Wheel Rim Abrasion Test Device 8 Figure 8 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL...—Reflectorized Bicycle Wheel Rim Abrasion Test Device EC03OC91.074...

  12. 77 FR 12761 - Special Regulations; Areas of the National Park System, Saguaro National Park, Bicycle Route

    Science.gov (United States)

    2012-03-02

    ...The National Park Service (NPS) is proposing to designate the Hope Camp Trail as a bicycle route within Saguaro National Park (Park). The National Park Service general regulation at 36 CFR 4.30(b) requires promulgation of a special regulation to designate bicycle routes outside of developed areas and special use...

  13. [A specific sign of the injury inflicted by the front wheel of a bicycle].

    Science.gov (United States)

    Leonov, S V; Pinchuk, P V; Molchanov, D V

    2016-01-01

    The authors report the results of the comprehensive forensic medical expertise of the injury inflicted by the front wheel of a bicycle that revealed a new specific sign of the contact between the protruding part of the wheel of the bicycle (the brake disk) and the pedestrian's body. PMID:27070037

  14. The unexpected stable market share of the bicycle in The Netherlands

    NARCIS (Netherlands)

    Van Goeverden, C.D.; Van Arem, B.; Godefrooij, T.

    2013-01-01

    In the Netherlands, the share of the bicycle as the main mode in all person trips has been highly constant in the past three decades (about 27%). A constant share is remarkable because a number of developments in this period were unfavourable for bicycle use, like ageing of the population, growing n

  15. Bicycle Design: A different approach to improving on the world human powered speed records

    NARCIS (Netherlands)

    Epema, H.K.; Van den Brand, S.; Gregoor, W.; Kooijman, J.D.G.; Pereboom, H.P.; Wielemaker, D.C.; Van der Zweep, C.J.

    2012-01-01

    The current International Human Powered Vehicle Association world records for faired bicycles stand at 133.284km/h for the 200m flying start speed record and 91.562 km for the hour record. Traditionally the recumbent bicycles that have been developed for breaking one of either of these records have

  16. Does pedalling on a recumbent bicycle influence the cyclist’s steering behaviour?

    NARCIS (Netherlands)

    Boon, K.M.; Klap, P.; Van Lanen, J.A.; Letsoin, G.J.; Jansen, A.J.

    2014-01-01

    The paper presents the answer to the question how pedalling on a specific recumbent bicycle, such as the VeloX3, influences a cyclist’s ability to steer the bicycle. The research aims to find the correlation between pedalling and the undesired steering movements it creates. To test this assumption a

  17. Getting Bicycles on Trains - Inter-modal Transport Developments in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Pedersen, Bjørn Brix

    2001-01-01

    The combined use of bicycles and trains has been favored in contemporary public transport policies in Denmark. Although bicycling has played a major role in Danish personal transportation in more than hundred years, the attitude from public transport authorities towards supporting bicyclists has...

  18. The Dutch Reference Study: Cases of interventions in bicycle infrastructure reviewed in the framework of Bikeability

    NARCIS (Netherlands)

    Van Goeverden, C.D.; Godefrooij, T.

    2011-01-01

    The Netherlands have a tradition of high bicycle usage and a long history of research on effective policies for promoting cycling. Findings in Dutch studies can be useful in the Danish Bikeability-project that has the objective to increase the level of knowledge in relation to bicycle based transpor

  19. Design Analysis And Applications Of A Regenerative Bicycle Ergometer

    OpenAIRE

    Chukwuneke J. L.; Ugwuegbu D. C.; Sinebe J. E.; Enyi L. C.

    2015-01-01

    Man needs to do some form of physical work in other to remain healthy this work is similar to the work done by any machine or equipment and thus should be channeled to give useful output but rather it is usually dissipated into the environment in form of heat. The regenerative bicycle ergometer takes advantage of the greater power generated by the limbs and arms thus conserves converts and stores the energy dissipated by the rider with an ideal mechanical advantage of 7.6 it strategically use...

  20. Can You Ride a Bicycle? The Ability to Ride a Bicycle Prevents Reduced Social Function in Older Adults With Mobility Limitation

    Directory of Open Access Journals (Sweden)

    Ryota Sakura

    2016-06-01

    Full Text Available Background: The health benefits of bicycling in older adults with mobility limitation (ML are unclear. We investigated ML and functional capacity of older cyclists by evaluating their instrumental activities of daily living (IADL, intellectual activity, and social function. Methods: On the basis of interviews, 614 community-dwelling older adults (after excluding 63 participants who never cycled were classified as cyclists with ML, cyclists without ML, non-cyclists with ML (who ceased bicycling due to physical difficulties, or non-cyclists without ML (who ceased bicycling for other reasons. A cyclist was defined as a person who cycled at least a few times per month, and ML was defined as difficulty walking 1 km or climbing stairs without using a handrail. Functional capacity and physical ability were evaluated by standardized tests. Results: Regular cycling was documented in 399 participants, and 74 of them (18.5% had ML; among non-cyclists, 49 had ML, and 166 did not. Logistic regression analysis for evaluating the relationship between bicycling and functional capacity revealed that non-cyclists with ML were more likely to have reduced IADL and social function compared to cyclists with ML. However, logistic regression analysis also revealed that the risk of bicycle-related falls was significantly associated with ML among older cyclists. Conclusions: The ability and opportunity to bicycle may prevent reduced IADL and social function in older adults with ML, although older adults with ML have a higher risk of falls during bicycling. It is important to develop a safe environment for bicycling for older adults.

  1. Vision-Based Bicycle Detection Using Multiscale Block Local Binary Pattern

    Directory of Open Access Journals (Sweden)

    Hongyu Hu

    2014-01-01

    Full Text Available Bicycle traffic has heavy proportion among all travel modes in some developing countries, which is crucial for urban traffic control and management as well as facility design. This paper proposes a real-time multiple bicycle detection algorithm based on video. At first, an effective feature called multiscale block local binary pattern (MBLBP is extracted for representing the moving object, which is a well-classified feature to distinguish between bicycles and nonbicycles; then, a cascaded bicycle classifier trained by AdaBoost algorithm is proposed, which has a good computation efficiency. Finally, the method is tested with video sequence captured from the real-world traffic scenario. The bicycles in the test scenario are successfully detected.

  2. Bicycle Riding: Impact on Lower Urinary Tract Symptoms and Erectile Function in Healthy Men

    Science.gov (United States)

    Baek, Seok; Lee, Sun Young; Kim, Jong Min; Shin, Esther; Kam, Sin

    2011-01-01

    Purpose Recently, reports in the mass media have implicated that bicycle riding increases the risk of erectile dysfunction and prostatic diseases. So, we evaluate the impact of bicycle riding on erectile function and lower urinary tract symptoms (LUTS) in healthy general men. Methods From 26 June 2010 to 20 July 2010, we investigate degree of LUTS (voiding and storage symptoms), using International Continence Society-male Questionnaire (ICS-mQ) and erectile function using International Index of Erectile Function-5 Questionnaire (IIEF-5) in 5 work places (personnel of public office, hospital, university, etc.) of which bicycle riding club members were doing active club activities. Respondents, who participated in club activities for 6 months and longer, were classified as the bicycle club (142 men; age, 44.02±8.56). Ones who do not ride bicycles were classified as the control group (83 men; age, 42.13±7.85). People who were having the history of urological and other chronic diseases (diabetes, vascular disease, heart disease, etc) were excluded from both groups. Results Bicycle club is not significantly associated with increased prevalence of LUTS (bicycle club, 2.1 to 57.7% control, 4.8 to 73.5%) and erectile dysfunction (bicycle club, 46.1% control, 55.4%). The total mean score (storage/voiding/erectile function) of bicycle club (13.93±1.95/11.14±3.49/20.46±5.30) were not significantly different from control (14.35±2.49/11.52±3.38/20.40±4.07) (P=0.190 to 0.968). Conclusions These results suggested that bicycle riding as exercise or hobby has no negative effect on LUTS and erectile function in healthy general men, although this research data were limited to the questionnaire analysis. PMID:21811700

  3. The influence of body mass in endurance bicycling.

    Science.gov (United States)

    Swain, D P

    1994-01-01

    Bicycling is a complex sport in which an athlete's energy cost is related to two principal forces: air resistance when traveling on flat terrain, and gravity when traveling uphill. Both wind tunnel data and physiological measurements suggest that air resistance scales as body mass to about the 1/3 power. Thus, large cyclists have only slightly greater frontal drags than small cyclists. If expressed relative to body mass, the frontal drag of small cyclists is considerably greater than that of large cyclists. The difference in frontal drag (energy cost) is not made up for by the advantage to small cyclists in relative VO2max (energy supply), since the mass exponent for drag (1/3) is closer to zero than that for VO2max (2/3). Thus, small cyclists should be at a disadvantage in flat time trials, which field data support. The energy cost of riding uphill slightly favors the large cyclist, because the weight of the bicycle represents a relatively smaller load than it does to a small cyclist. The mass exponent is 0.79. Since this exponent is greater than that for VO2max, the small cyclists have an advantage in climbing, which is supported by field data. PMID:8133740

  4. Harvesting Energy from the Counterbalancing (Weaving Movement in Bicycle Riding

    Directory of Open Access Journals (Sweden)

    Shashank Priya

    2012-07-01

    Full Text Available Bicycles are known to be rich source of kinetic energy, some of which is available for harvesting during speedy and balanced maneuvers by the user. A conventional dynamo attached to the rim can generate a large amount of output power at an expense of extra energy input from the user. However, when applying energy conversion technology to human powered equipments, it is important to minimize the increase in extra muscular activity and to maximize the efficiency of human movements. This study proposes a novel energy harvesting methodology that utilizes lateral oscillation of bicycle frame (weaving caused by user weight shifting movements in order to increase the pedaling force in uphill riding or during quick speed-up. Based on the 3D motion analysis, we designed and implemented the prototype of an electro-dynamic energy harvester that can be mounted on the bicycle’s handlebar to collect energy from the side-to-side movement. The harvester was found to generate substantial electric output power of 6.6 mW from normal road riding. It was able to generate power even during uphill riding which has never been shown with other approaches. Moreover, harvesting of energy from weaving motion seems to increase the economy of cycling by helping efficient usage of human power.

  5. An improved multi-value cellular automata model for heterogeneous bicycle traffic flow

    International Nuclear Information System (INIS)

    This letter develops an improved multi-value cellular automata model for heterogeneous bicycle traffic flow taking the higher maximum speed of electric bicycles into consideration. The update rules of both regular and electric bicycles are improved, with maximum speeds of two and three cells per second respectively. Numerical simulation results for deterministic and stochastic cases are obtained. The fundamental diagrams and multiple states effects under different model parameters are analyzed and discussed. Field observations were made to calibrate the slowdown probabilities. The results imply that the improved extended Burgers cellular automata (IEBCA) model is more consistent with the field observations than previous models and greatly enhances the realism of the bicycle traffic model. - Highlights: • We proposed an improved multi-value CA model with higher maximum speed. • Update rules are introduced for heterogeneous bicycle traffic with maximum speed 2 and 3 cells/s. • Simulation results of the proposed model are consistent with field bicycle data. • Slowdown probabilities of both regular and electric bicycles are calibrated

  6. Bicycle Guidelines and Crash Rates on Cycle Tracks in the United States

    Science.gov (United States)

    Morency, Patrick; Miranda-Moreno, Luis F.; Willett, Walter C.; Dennerlein, Jack T.

    2013-01-01

    Objectives. We studied state-adopted bicycle guidelines to determine whether cycle tracks (physically separated, bicycle-exclusive paths adjacent to sidewalks) were recommended, whether they were built, and their crash rate. Methods. We analyzed and compared US bicycle facility guidelines published between 1972 and 1999. We identified 19 cycle tracks in the United States and collected extensive data on cycle track design, usage, and crash history from local communities. We used bicycle counts and crash data to estimate crash rates. Results. A bicycle facility guideline written in 1972 endorsed cycle tracks but American Association of State Highway and Transportation Officials (AASHTO) guidelines (1974–1999) discouraged or did not include cycle tracks and did not cite research about crash rates on cycle tracks. For the 19 US cycle tracks we examined, the overall crash rate was 2.3 (95% confidence interval = 1.7, 3.0) per 1 million bicycle kilometers. Conclusions. AASHTO bicycle guidelines are not explicitly based on rigorous or up-to-date research. Our results show that the risk of bicycle–vehicle crashes is lower on US cycle tracks than published crashes rates on roadways. This study and previous investigations support building cycle tracks. PMID:23678920

  7. An improved multi-value cellular automata model for heterogeneous bicycle traffic flow

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Sheng [College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310058 China (China); Qu, Xiaobo [Griffith School of Engineering, Griffith University, Gold Coast, 4222 Australia (Australia); Xu, Cheng [Department of Transportation Management Engineering, Zhejiang Police College, Hangzhou, 310053 China (China); College of Transportation, Jilin University, Changchun, 130022 China (China); Ma, Dongfang, E-mail: mdf2004@zju.edu.cn [Ocean College, Zhejiang University, Hangzhou, 310058 China (China); Wang, Dianhai [College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310058 China (China)

    2015-10-16

    This letter develops an improved multi-value cellular automata model for heterogeneous bicycle traffic flow taking the higher maximum speed of electric bicycles into consideration. The update rules of both regular and electric bicycles are improved, with maximum speeds of two and three cells per second respectively. Numerical simulation results for deterministic and stochastic cases are obtained. The fundamental diagrams and multiple states effects under different model parameters are analyzed and discussed. Field observations were made to calibrate the slowdown probabilities. The results imply that the improved extended Burgers cellular automata (IEBCA) model is more consistent with the field observations than previous models and greatly enhances the realism of the bicycle traffic model. - Highlights: • We proposed an improved multi-value CA model with higher maximum speed. • Update rules are introduced for heterogeneous bicycle traffic with maximum speed 2 and 3 cells/s. • Simulation results of the proposed model are consistent with field bicycle data. • Slowdown probabilities of both regular and electric bicycles are calibrated.

  8. Predicting Free Flow Speed and Crash Risk of Bicycle Traffic Flow Using Artificial Neural Network Models

    Directory of Open Access Journals (Sweden)

    Cheng Xu

    2015-01-01

    Full Text Available Free flow speed is a fundamental measure of traffic performance and has been found to affect the severity of crash risk. However, the previous studies lack analysis and modelling of impact factors on bicycles’ free flow speed. The main focus of this study is to develop multilayer back propagation artificial neural network (BPANN models for the prediction of free flow speed and crash risk on the separated bicycle path. Four different models with considering different combinations of input variables (e.g., path width, traffic condition, bicycle type, and cyclists’ characteristics were developed. 459 field data samples were collected from eleven bicycle paths in Hangzhou, China, and 70% of total samples were used for training, 15% for validation, and 15% for testing. The results show that considering the input variables of bicycle types and characteristics of cyclists will effectively improve the accuracy of the prediction models. Meanwhile, the parameters of bicycle types have more significant effect on predicting free flow speed of bicycle compared to those of cyclists’ characteristics. The findings could contribute for evaluation, planning, and management of bicycle safety.

  9. Cyclist safety on bicycle boulevards and parallel arterial routes in Berkeley, California.

    Science.gov (United States)

    Minikel, Eric

    2012-03-01

    This study compares the safety of bicyclists riding on bicycle boulevards to those riding on parallel arterial routes in Berkeley, California. Literature on the impact of motor vehicle traffic characteristics on cyclist safety shows that high motor vehicle speeds and volumes and the presence of heavy vehicles are all detrimental to cyclist safety. This suggests that cyclists may be safer on side streets than on busy arterials. Bicycle boulevards-traffic-calmed side streets signed and improved for cyclist use-purport to offer cyclists a safer alternative to riding on arterials. Police-reported bicycle collision data and manually collected cyclist count data from bicycle boulevards and parallel arterial routes in Berkeley, California from 2003 to 2010 are used to test the hypothesis that Berkeley's bicycle boulevards have lower cyclist collision rates and a lower proportion of bicycle collisions resulting in severe injury. While no significant difference is found in the proportion of collisions that are severe, results show that collision rates on Berkeley's bicycle boulevards are two to eight times lower than those on parallel, adjacent arterial routes. The difference in collision rate is highly statistically significant, unlikely to be caused by any bias in the collision and count data, and cannot be easily explained away by self-selection or safety in numbers. Though the used dataset is limited and the study design is correlational, this study provides some evidence that Berkeley's bicycle boulevards are safer for cyclists than its parallel arterial routes. The results may be suggestive that, more generally, properly implemented bicycle boulevards can provide cyclists with a safer alternative to riding on arterials. PMID:22269506

  10. Optimal Time-Trial Bicycle Racing with Headwinds and Tailwinds

    CERN Document Server

    Anton, A Brad

    2013-01-01

    Many time-trial and triathlon bicycle races take place on relatively flat, closed-circuit courses. In the absence of hills, riding-speed is limited almost solely by aerodynamic drag; consequently, winds can have a big effect on elapsed times. I analyze the special case of a straight out-and-back race in a steady wind, assuming the rider has a given total amount of energy to expend and can choose only two speeds - the aided speed with tailwind and the hindered speed into headwind. In this ideal circumstance the problem of choosing optimal riding speeds reduces to a constrained nonlinear optimization that can be solved with elementary calculus. My analysis reveals a practical rule of thumb that can be used more generally to choose optimal riding speeds for time-trial racing on closed-circuit courses in the presence of headwinds and tailwinds.

  11. [Prognostic significance of bicycle ergometry test in patients with myocarditis].

    Science.gov (United States)

    Gavalova, R F; Borodina, V I

    1992-04-01

    A total of 42 patients with rheumatic carditis were examined in the acute-subacute period and following 3-5 years. Seventeen patients were diagnosed as having primary rheumatic carditis, 9 presented with tonsillogenic rheumatic carditis, and 16 had viral rheumatic carditis. The diagnosis of myocarditis was established on the basis of clinical, immunological, and virological findings. The study involved ECG, PhCG, PCG, and bicycle ergometer testing recordings. Groups of patients with good and poor prognosis were identified. Low threshold exercise, exercise-inadequate tachycardia, complex cardiac arrhythmias, phasic myocardial hypodynamic syndrome and volume exercise syndrome that are formed during performance are prognostically poor indicators. More profound electric and mechanic dysfunctions were observed in patients with tonsillogenic or viral myocarditis.

  12. Synthesis of bicyclic alkaloids from the iridoid antirrhinoside

    DEFF Research Database (Denmark)

    Frederiksen, Signe Maria

    The present thesis describes the isolation of the iridoid glucoside antirrhinoside from Antirrhinum majus, and the approaches made towards its transformation into analogues of biologically active compounds, with special interest in syntheses of bicyclic alkaloids.A synthetic piperidine monoterpene...... alkaloid was prepared from antirrhinoside by means of an enzymatic cleavage to afford the aglucone, followed by a double reductive amination with benzylamine hydrochloride and sodium cyanoborohydride. The resulting piperidine was modified by opening of the epoxide on the cyclopropane ring by azide...... strategy was therefore abandoned.A one-pot reaction involving ozonolysis and subsequent reduction of the 5,6-O-isopropylidene-2',3',4',6'-tetra-O-acetyl antirrhinoside yielded a diol, which was considered a potential intermediate in the preparation of enantiopure 3-azabicyclo[3.3.0]octane alkaloids...

  13. Consumers’ preferences for “bicycle poultry” in Benin

    DEFF Research Database (Denmark)

    Sodjinou, Epiphane; Henningsen, Arne; Koudande, Delphin O.;

    Village poultry, also termed "bicycle poultry," is produced in scavenging farming systems and is a chewy meat with a low fat content, and constitutes an important source of meat in many African countries. This study investigates consumers’ preferences regarding the physical traits of these birds...... are willing to pay a premium for these types of birds. The factors which significantly influence the price of chicken are the breed of the bird, the plumage color, the meatiness and the age of the bird. Consumers are willing to pay a price premium for meatier birds of traditional breeds with white plumage...... color and aged between six and twelve months. Thus, efforts to improve local breeds should stress these preferred traits....

  14. Aromatic Esters of Bicyclic Amines as Antimicrobials against Streptococcus pneumoniae.

    Science.gov (United States)

    de Gracia Retamosa, María; Díez-Martínez, Roberto; Maestro, Beatriz; García-Fernández, Esther; de Waal, Bas; Meijer, E W; García, Pedro; Sanz, Jesús M

    2015-11-01

    A double approach was followed in the search of novel inhibitors of the surface choline-binding proteins (CBPs) of Streptococcus pneumoniae (pneumococcus) with antimicrobial properties. First, a library of 49 rationally-designed esters of alkyl amines was screened for their specific binding to CBPs. The best binders, being esters of bicyclic amines (EBAs), were then tested for their in vitro effect on pneumococcal growth and morphology. Second, the efficiency of EBA-induced CBP inhibition was enhanced about 45,000-fold by multivalency effects upon synthesizing a poly(propylene imine) dendrimer containing eight copies of an atropine derivative. Both approaches led to compounds that arrest bacterial growth, dramatically decrease cell viability, and exhibit a protection effect in animal disease models, demonstrating that the pneumococcal CBPs are adequate targets for the discovery of novel antimicrobials that overcome the currently increasing antimicrobial resistance issues. PMID:26377931

  15. Synthesis and screening of bicyclic carbohydrate-based compounds: a novel type of antivirals.

    Science.gov (United States)

    Van Hoof, Steven; Ruttens, Bart; Hubrecht, Idzi; Smans, Gert; Blom, Petra; Sas, Benedikt; Van hemel, Johan; Vandenkerckhove, Jan; Van der Eycken, Johan

    2006-03-15

    A small library of bicyclic carbohydrate derivatives was synthesized and screened. A strong and selective activity against cytomegalovirus was found. Structure-activity relationship for this new type of antivirals is discussed.

  16. Prioritization of Integrated Bicycle Network Clusters in Istanbul Using Analytic Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Dilek Çol Yılmaz

    2014-06-01

    Full Text Available In this study, the impact of the integration of nonmotorized transport and public transport on hypermobility was evaluated. The role of bicycle in non-motorized transportation, and its contribution to sustainable travel goals were examined. A decision support model was established in order to plan the phases of a bicycle network integrated with the public transport sytem in Istanbul Metropolitan Area. Data such as public transport routes planned for the target year 2023, locations of transfer centers, number of passengers at transfer centers, and a revised bicycle network were used as layers for the Geographic Information Systems (GIS map produced. Based on the survey data collected from the experts, Analytic Hierarchy Process (AHP which is a multi-criteria decision-making procedure that contains both qualitative and quantitative factors was used to prioritize the bicycle network clusters integrated with public transport system in Istanbul.

  17. EU to Continue 48.5% Anti-dumping Duties on Chinese Bicycles

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On June 10, European Commission informed the Business Office of the Mission of Ministry of Commerce in EU and disclosed the adjudication on the review of the EU imposing anti-dumping on Chinese bicycles.

  18. Sleep Deprivation Is Associated with Bicycle Accidents and Slip and Fall Injuries in Korean Adolescents.

    Directory of Open Access Journals (Sweden)

    So Young Kim

    Full Text Available This study sought to evaluate associations between sleep time and bicycle accidents, falls under various circumstances, and dental injuries in adolescents.A total of 61,696 participants ranging from 12 to 18 years of age who completed the Korea Youth Risk Behavior Web-based Survey (KYRBWS in 2013 were enrolled in this study. Bicycle riding accidents were analyzed for 17,232 bicycle-riding participants. Data were collected regarding the weekday sleep duration for the most recent 7 days, which was categorized as the 5.5-6.5 h group > the 6.5-7.5 h group. There was no significant relationship between sleep deprivation and dental injury.This study demonstrated that sleep deprivation among Korean adolescents was associated with bicycle accidents and falls at home and school. Thus, adequate sleep may be needed to prevent accidents and falls.

  19. Physiological responses and exercise preference between the Trikke and the bicycle ergometer

    Directory of Open Access Journals (Sweden)

    Eddie T.C. Lam

    2016-06-01

    Conclusion: Participants were more efficient in using the Trikke than the bicycle ergometer. The Trikke may be an enjoyable alternative for those individuals, particularly women, who have lost interest in traditional forms of exercise.

  20. An Analyses of Bicycle Accidents in Ankara: Analyses of 5 Years

    Directory of Open Access Journals (Sweden)

    Muhittin Yilmaz

    2014-12-01

    Full Text Available Aim: Bicycles are used for transportation, exercise and recreation. In this study we aimed to investigate the epidemiological, clinical and economic aspects of bicycle injuries. Material and Method: We included in the study who admitted to the Emergency Department with a bicycle accident between January 2008 and July 2012. Patient age and sex, accident pattern, presence of personal protective measures, injured body part, Glasgow Coma Scale (GCS score, Revised Trauma Score (RTS, radiological findings, requested consultations, duration of hospital stay, season of injury, and average cost rates were recorded. The study population was divided into 2 age groups as 0-14 years and over 14 years. Results: A patients were 238 (81.2% male and their mean age was 31.5±14.1 years. Fifty-five (18.8% patients were female and their mean age was 34.5±15.9 years. Males had significantly higher rate of bicycle injury (p

  1. Isn't it time to take bicycles seriously again in Beijing ?%Isn't it time to take bicycles seriously again in Beijing ?

    Institute of Scientific and Technical Information of China (English)

    Shannon Bufton; Florian Lorenz

    2011-01-01

    The humble bicycle was once the predominant mode of transport in Beijing and it can be argued that the city has previously been one of the best bicycle cities in the world. Now the streets are littered with rusting old bikes and it seems as if Beijing has turned its back on the bicycle in its quest for modernity and evolution. The resultant re-configuration of the city and the rapid speed of development of modern transportation systems (particularly the lightening growth of personal automobiles) have created a complex set of issues and challenges which now put the city under pressure such as sustainability, air quality, health and traffic congestion problems.

  2. Modeling and simulation of the transmission system for a chainless electric bicycle

    OpenAIRE

    Garcia Farreny, Alex

    2015-01-01

    This project, entitled Modeling and Simulation of the Transmission System for a Chainless Electric Bicycle, consists in the design of the controllers’ logics governing a chainless electric bicycle’s transmission in order to accomplish certain behavior in front of inputs such as pedaling torque, slope gradient, frontal wind, gear selected, etc. To better understand it, a chainless electric bicycle replaces the conventional mechanical transmission (chain) by two electric mac...

  3. Teaching children about bicycle safety: an evaluation of the New Jersey Bike School program.

    Science.gov (United States)

    Lachapelle, Ugo; Noland, Robert B; Von Hagen, Leigh Ann

    2013-03-01

    There are multiple health and environmental benefits associated with increasing bicycling among children. However, the use of bicycles is also associated with severe injuries and fatalities. In order to reduce bicycle crashes, a bicycling education program was implemented in selected New Jersey schools and summer camps as part of the New Jersey Safe Routes to School Program. Using a convenience sample of participants to the program, an opportunistic study was designed to evaluate the effectiveness of two bicycle education programs, the first a more-structured program delivered in a school setting, with no on-road component, and the other a less structured program delivered in a summer camp setting that included an on-road component. Tests administered before and after training were designed to assess knowledge acquired during the training. Questions assessed children's existing knowledge of helmet use and other equipment, bicycle safety, as well as their ability to discriminate hazards and understand rules of the road. Participating children (n=699) also completed a travel survey that assessed their bicycling behavior and their perception of safety issues. Response to individual questions, overall pre- and post-training test scores, and changes in test scores were compared using comparison of proportion, t-tests, and ordinary least-squares (OLS) regression. Improvements between the pre-training and post-training test are apparent from the frequency distribution of test results and from t-tests. Both summer camps and school-based programs recorded similar improvements in test results. Children who bicycled with their parents scored higher on the pre-training test but did not improve as much on the post-training test. Without evaluating long-term changes in behavior, it is difficult to ascertain how successful the program is on eventual behavioral and safety outcomes.

  4. A Modified Cellular Automaton Approach for Mixed Bicycle Traffic Flow Modeling

    Directory of Open Access Journals (Sweden)

    Xiaonian Shan

    2015-01-01

    Full Text Available Several previous studies have used the Cellular Automaton (CA for the modeling of bicycle traffic flow. However, previous CA models have several limitations, resulting in differences between the simulated and the observed traffic flow features. The primary objective of this study is to propose a modified CA model for simulating the characteristics of mixed bicycle traffic flow. Field data were collected on physically separated bicycle path in Shanghai, China, and were used to calibrate the CA model using the genetic algorithm. Traffic flow features between simulations of several CA models and field observations were compared. The results showed that our modified CA model produced more accurate simulation for the fundamental diagram and the passing events in mixed bicycle traffic flow. Based on our model, the bicycle traffic flow features, including the fundamental diagram, the number of passing events, and the number of lane changes, were analyzed. We also analyzed the traffic flow features with different traffic densities, traffic components on different travel lanes. Results of the study can provide important information for understanding and simulating the operations of mixed bicycle traffic flow.

  5. Bicycle helmet use and non-use – recently published research

    Science.gov (United States)

    2012-01-01

    Bicycle traumata are very common and especially neurologic complications lead to disability and death in all stages of the life. This review assembles the most recent findings concerning research in the field of bicycle traumata combined with the factor of bicycle helmet use. The area of bicycle trauma research is by nature multidisciplinary and relevant not only for physicians but also for experts with educational, engineering, judicial, rehabilitative or public health functions. Due to this plurality of global publications and special subjects, short time reviews help to detect recent research directions and provide also information from neighbour disciplines for researchers. It can be stated that to date, that although a huge amount of research has been conducted in this area more studies are needed to evaluate and improve special conditions and needs in different regions, ages, nationalities and to create successful prevention programs of severe head and face injuries while cycling. Focus was explicit the bicycle helmet use, wherefore sledding, ski and snowboard studies were excluded and only one study concerning electric bicycles remained due to similar motion structures within this review. The considered studies were all published between January 2010 and August 2011 and were identified via the online databases Medline PubMed and ISI Web of Science. PMID:22632628

  6. Association of Sociodemographic and Perceived Environmental Factors with Public Bicycle Use among Taiwanese Urban Adults

    Directory of Open Access Journals (Sweden)

    Yung Liao

    2016-03-01

    Full Text Available Background: This study examined the sociodemographic and perceived environmental factors associated with public bicycle use among Taiwanese urban adults. Methods: A random-digit-dialing telephone-based cross-sectional survey was administered to Taiwanese urban adults aged 20–64 years in 2015. Data on sociodemographic variables, perceived environmental factors (for attributes identified in the International Physical Activity Questionnaire-Environmental Module, and public bicycle use were obtained from 1002 adults in three cities. Adjusted logistic regression was used. Results: After adjustment for potential confounders, the results showed that adults aged 20–29 years (odds ratio (OR = 4.42 with a university degree or higher (OR = 2.03 were more likely to use public bicycles. In addition, adults living in Kaohsiung City were less likely to use public bicycles (OR = 0.24. Adults who saw people being active (OR = 1.76; 95% CI: 1.05–2.86 and had positive aesthetic experiences of their environment (OR = 1.69 were more likely to use public bicycles. Conclusions: Our findings suggest that seeing physically active people and positive aesthetic perceptions of the environment are key factors for developing transportation policies and intervention strategies for promoting public bicycle use among Taiwanese urban adults.

  7. The Effects of Surface-Induced Loads on Forearm Muscle Activity During Steering a Bicycle

    Science.gov (United States)

    Arpinar-Avsar, Pinar; Birlik, Gülin; Sezgin, Önder C.; Soylu, Abdullah R.

    2013-01-01

    On the bicycle, the human upper extremity has two essential functions in steering the bicycle and in supporting the body. Through the handlebar, surface- induced loads are transmitted to the hand and arm of the bicycle rider under vibration exposure conditions. Thus, the purpose of the study was to investigate the effect of vibration exposure on forearm muscle activity for different road surfaces (i.e. smooth road, concrete stone pavement, rough road) and for different bicycles. Ten subjects participated in experiments and two types of bicycles, i.e. Road Bike (RB) and Mountain Bike (MTB) are compared. The acceleration magnitudes were dominant along x and z-axes. The r.m.s acceleration values in the z direction at the stem of MTB were at most 2.56, 7.04 and 10.76 m·s-2 when pedaling respectively on asphalt road, concrete pavement and rough road. In the case of RB the corresponding values were respectively 4.43, 11.75 and 27.31 m·s-2. The cumulative normalized muscular activity levels during MTB trials on different surfaces had the same tendency as with acceleration amplitudes and have ranked in the same order from lowest to highest value. Although road bike measurements have resulted in a similar trend of increment, the values computed for rough road trials were higher than those in MTB trials. During rough road measurements on MTB, rmsEMG of extensor muscles reached a value corresponding to approximately 50% of MVC (Maximum Voluntary Contraction). During RB trials performed on rough road conditions, rmsEMG (%MVC) values for the forearm flexor muscles reached 45.8% of their maximal. The level of muscular activity of forearm muscles in controlling handlebar movements has been observed to be enhanced by the increase in the level of vibration exposed on the bicycle. Since repeated forceful gripping and pushing forces to a handle of a vibratory tool can create a risk of developing circulatory, neurological, or musculoskeletal disorder, a bicycle rider can be

  8. Incidence and costs of bicycle-related traumatic brain injuries in the Netherlands.

    Science.gov (United States)

    Scholten, Annemieke C; Polinder, Suzanne; Panneman, Martien J M; van Beeck, Ed F; Haagsma, Juanita A

    2015-08-01

    The main cause of death and serious disability in bicycle accidents is traumatic brain injury (TBI). The aim of this population-based study was to assess the incidence and costs of bicycle-related TBI across various age groups, and in comparison to all bicycle-related injuries, to identify main risk groups for the development of preventive strategies. Data from the National Injury Surveillance System and National Medical Registration were used for all patients with bicycle-related injuries and TBI who visited a Dutch emergency department (ED) between 1998 and 2012. Demographics and national, weighted estimates of injury mechanism, injury severity and costs were analysed per age group. Direct healthcare costs and indirect costs were determined using the incidence-based Dutch Burden of Injury Model. Between 1998 and 2012, the incidence of ED treatments due to bicycle-related TBI strongly increased with 54%, to 43 per 100,000 persons in 2012. However, the incidence of all bicycle-related injuries remained stable, from 444 in 1998 to 456/100,000 in 2012. Incidence of hospital admission increased in both TBI (92%) and all injuries from cycling (71%). Highest increase in incidence of both ED treatments and hospital admissions was seen in adults aged 55+. The injury rate of TBI per kilometre travelled increased (44%) except in children, but decreased (-4%) for all injuries, showing a strong decrease in children (-36%) but an increase in men aged 25+, and women aged 15+. Total costs of bicycle-related TBI were €74.5 million annually. Although bicycle-related TBI accounted for 9% of the incidence of all ED treatments due to cycling, it accounted for 18% of the total costs due to all bicycle-related injuries (€410.7 million). Children and adolescents (aged 0-24) had highest incidence of ED treatments due to bicycle-related injuries. Men in the working population (aged 15-64) had highest indirect costs following injuries from cycling, including TBI. Older cyclists (aged

  9. Optimization of electric bicycle for youths with disabilities.

    Science.gov (United States)

    Blumenstein, Tobias; Zeitlmann, Hilar; Alves-Pinto, Ana; Turova, Varvara; Lampe, Renée

    2014-01-01

    Cerebral palsy is a group of neurodevelopmental disorders that affect a person's ability to move and to maintain balance and posture. People with cerebral palsy have also perception and space orientation deficits so that special assistance devices should be developed to compensate these handicaps. The objective was to optimize an adapted electric bicycle (E-bike) for youths with neurodevelopmental disorders. An adapted E-bike was provided with ultrasonic sensors that measure distances to objects. If the distance to other objects reduces, an acoustic signal is sent. Additionally, a self-created force plate was fixed on the pedal to evaluate the muscle performances during biking. An experiment with the ultrasound warning system confirmed that acoustic feedback was helpful in avoiding obstacles. The measurement of the blood pressure, the heart frequency and the pedaling force during biking approved that the training condition of the test person can be registered and enables tuning the power of the electric motor to individual requirements. The results demonstrate that an adapted E-bike can be improved to provide better space orientation for people with perceptual disorders and to measure training conditions of patients. Moreover, these enable individual adjustment of the electric motor power to optimize comfort and therapy effect. PMID:25485189

  10. Big Bicycle Data Processing: from Personal Data to Urban Applications

    Science.gov (United States)

    Pettit, C. J.; Lieske, S. N.; Leao, S. Z.

    2016-06-01

    Understanding the flows of people moving through the built environment is a vital source of information for the planners and policy makers who shape our cities. Smart phone applications enable people to trace themselves through the city and these data can potentially be then aggregated and visualised to show hot spots and trajectories of macro urban movement. In this paper our aim is to develop procedures for cleaning, aggregating and visualising human movement data and translating this into policy relevant information. In conducting this research we explore using bicycle data collected from a smart phone application known as RiderLog. We focus on the RiderLog application initially in the context of Sydney, Australia and discuss the procedures and challenges in processing and cleaning this data before any analysis can be made. We then present some preliminary map results using the CartoDB online mapping platform where data are aggregated and visualised to show hot spots and trajectories of macro urban movement. We conclude the paper by highlighting some of the key challenges in working with such data and outline some next steps in processing the data and conducting higher volume and more extensive analysis.

  11. Environmental Determinants of Bicycling Injuries in Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Nicole T. R. Romanow

    2012-01-01

    Full Text Available This study examined environmental risk factors for bicycling injuries, by combining data on bicyclist injuries collected by interviews in the emergency department (ED with street-level environmental audits of injury locations, capturing path, roadway, safety, land use, and aesthetic characteristics. Cases were bicyclists struck by a motor vehicle (MV or with severe injuries (hospitalized. Controls were bicyclists who were not hit by a car or those seen and discharged from the ED, matched on time and day of injury. Logistic regression odds ratios (ORs adjusted for age, sex, peak time, and bicyclist speed with 95% confidence intervals (CIs were estimated to relate injury risk to environmental characteristics. Factors contributing to MV events included greater traffic volume (OR 5.13; 95% CI [1.44, 18.27], intersections (OR 6.89; 95% CI [1.48, 32.14], retail establishments (OR 5.56; 95% CI [1.72, 17.98], and path obstructions (OR 3.83; 95% CI [1.03, 14.25]. Locations where the road was in good condition (OR 0.25; 95% CI [0.07, 0.96] and where there was high surveillance from surrounding buildings (OR 0.32; 95% CI [0.13, 0.82] were associated with less severe injuries. These findings could be used by bicyclists and transportation planners to improve safety.

  12. Environmental Determinants of Bicycling Injuries in Alberta, Canada

    Science.gov (United States)

    Romanow, Nicole T. R.; Couperthwaite, Amy B.; McCormack, Gavin R.; Nettel-Aguirre, Alberto; Rowe, Brian H.; Hagel, Brent E.

    2012-01-01

    This study examined environmental risk factors for bicycling injuries, by combining data on bicyclist injuries collected by interviews in the emergency department (ED) with street-level environmental audits of injury locations, capturing path, roadway, safety, land use, and aesthetic characteristics. Cases were bicyclists struck by a motor vehicle (MV) or with severe injuries (hospitalized). Controls were bicyclists who were not hit by a car or those seen and discharged from the ED, matched on time and day of injury. Logistic regression odds ratios (ORs) adjusted for age, sex, peak time, and bicyclist speed with 95% confidence intervals (CIs) were estimated to relate injury risk to environmental characteristics. Factors contributing to MV events included greater traffic volume (OR 5.13; 95% CI [1.44, 18.27]), intersections (OR 6.89; 95% CI [1.48, 32.14]), retail establishments (OR 5.56; 95% CI [1.72, 17.98]), and path obstructions (OR 3.83; 95% CI [1.03, 14.25]). Locations where the road was in good condition (OR 0.25; 95% CI [0.07, 0.96]) and where there was high surveillance from surrounding buildings (OR 0.32; 95% CI [0.13, 0.82]) were associated with less severe injuries. These findings could be used by bicyclists and transportation planners to improve safety. PMID:23251192

  13. The Aeroflex: A Bicycle for Mobile Air Quality Measurements

    Directory of Open Access Journals (Sweden)

    Bart Elen

    2012-12-01

    Full Text Available Fixed air quality stations have limitations when used to assess people's real life exposure to air pollutants. Their spatial coverage is too limited to capture the spatial variability in, e.g., an urban or industrial environment. Complementary mobile air quality measurements can be used as an additional tool to fill this void. In this publication we present the Aeroflex, a bicycle for mobile air quality monitoring. The Aeroflex is equipped with compact air quality measurement devices to monitor ultrafine particle number counts, particulate mass and black carbon concentrations at a high resolution (up to 1 second. Each measurement is automatically linked to its geographical location and time of acquisition using GPS and Internet time. Furthermore, the Aeroflex is equipped with automated data transmission, data pre-processing and data visualization. The Aeroflex is designed with adaptability, reliability and user friendliness in mind. Over the past years, the Aeroflex has been successfully used for high resolution air quality mapping, exposure assessment and hot spot identification. 

  14. On the closure of the extended bicyclic semigroup

    CERN Document Server

    Fihel, Iryna

    2012-01-01

    In the paper we study the semigroup $\\mathscr{C}_{\\mathbb{Z}}$ which is a generalization of the bicyclic semigroup. We describe main algebraic properties of the semigroup $\\mathscr{C}_{\\mathbb{Z}}$ and prove that every non-trivial congruence $\\mathfrak{C}$ on the semigroup $\\mathscr{C}_{\\mathbb{Z}}$ is a group congruence, and moreover the quotient semigroup $\\mathscr{C}_{\\mathbb{Z}}/\\mathfrak{C}$ is isomorphic to a cyclic group. Also we show that the semigroup $\\mathscr{C}_{\\mathbb{Z}}$ as a Hausdorff semitopological semigroup admits only the discrete topology. Next we study the closure $\\operatorname{cl}_T(\\mathscr{C}_{\\mathbb{Z}})$ of the semigroup $\\mathscr{C}_{\\mathbb{Z}}$ in a topological semigroup $T$. We show that the non-empty remainder of $\\mathscr{C}_{\\mathbb{Z}}$ in a topological inverse semigroup $T$ consists of a group of units $H(1_T)$ of $T$ and a two-sided ideal $I$ of $T$ in the case when $H(1_T)\

  15. Bicycle accident-related head injuries in India

    Science.gov (United States)

    Munivenkatappa, Ashok; Devi, Bhagavatula Indira; Gregor, Thomas Issac; Bhat, Dhananjay I.; Kumarsamy, Akhil Deepika; Shukla, Dhaval P.

    2013-01-01

    Objectives: To describe the epidemiology of head injuries sustained due to bicycle accidents in India. Materials and Methods: Data were retrospectively collected over a period of six months (15 May 2011 to 15 November 2011). Demography of patients, Glasgow coma scale (GCS), clinical and imaging findings, and mortality and outcome using Glasgow outcome scale (GOS), Rivermead post-concussion symptom questionnaire (RPCSQ) and Rivermead head injury follow-up questionnaire (RHFUQ), were analyzed. Outcome was assessed by telephonic interview. Results: There were 108 patients (100 males) with mean age of 27.7 years. Seventy-four (68.5%) were from rural areas. Accidents due to vehicular collision accounted for 60 (55.6%) cases. None wore a helmet. The admission GCS was 14-15 in 68.5% cases, 13-3 in 31.5%. The risk of moderate to severe injuries was increased among working laborers (OR = 5), and patients with loss of consciousness (OR = 4). Sixty-three (49%) patients had abnormal computed tomography (CT) findings; most common finding was skull fracture 25 (23.1%). Four patients needed surgery. The GOS assessment at three to six months revealed favorable outcome in 66 patients (61.1%) and death in 8 (7.4%). The common post-concussion symptoms were headache, fatigue, and poor concentration. Conclusion: The majority of hospitalized cyclists were from a rural background and of the lower income group. After three months the majority of patients had good recovery with few persistent concussion symptoms. PMID:24250156

  16. The Aeroflex: A Bicycle for Mobile Air Quality Measurements

    Science.gov (United States)

    Elen, Bart; Peters, Jan; Van Poppel, Martine; Bleux, Nico; Theunis, Jan; Reggente, Matteo; Standaert, Arnout

    2013-01-01

    Fixed air quality stations have limitations when used to assess people's real life exposure to air pollutants. Their spatial coverage is too limited to capture the spatial variability in, e.g., an urban or industrial environment. Complementary mobile air quality measurements can be used as an additional tool to fill this void. In this publication we present the Aeroflex, a bicycle for mobile air quality monitoring. The Aeroflex is equipped with compact air quality measurement devices to monitor ultrafine particle number counts, particulate mass and black carbon concentrations at a high resolution (up to 1 second). Each measurement is automatically linked to its geographical location and time of acquisition using GPS and Internet time. Furthermore, the Aeroflex is equipped with automated data transmission, data pre-processing and data visualization. The Aeroflex is designed with adaptability, reliability and user friendliness in mind. Over the past years, the Aeroflex has been successfully used for high resolution air quality mapping, exposure assessment and hot spot identification. PMID:23262484

  17. Optimization of electric bicycle for youths with disabilities.

    Science.gov (United States)

    Blumenstein, Tobias; Zeitlmann, Hilar; Alves-Pinto, Ana; Turova, Varvara; Lampe, Renée

    2014-01-01

    Cerebral palsy is a group of neurodevelopmental disorders that affect a person's ability to move and to maintain balance and posture. People with cerebral palsy have also perception and space orientation deficits so that special assistance devices should be developed to compensate these handicaps. The objective was to optimize an adapted electric bicycle (E-bike) for youths with neurodevelopmental disorders. An adapted E-bike was provided with ultrasonic sensors that measure distances to objects. If the distance to other objects reduces, an acoustic signal is sent. Additionally, a self-created force plate was fixed on the pedal to evaluate the muscle performances during biking. An experiment with the ultrasound warning system confirmed that acoustic feedback was helpful in avoiding obstacles. The measurement of the blood pressure, the heart frequency and the pedaling force during biking approved that the training condition of the test person can be registered and enables tuning the power of the electric motor to individual requirements. The results demonstrate that an adapted E-bike can be improved to provide better space orientation for people with perceptual disorders and to measure training conditions of patients. Moreover, these enable individual adjustment of the electric motor power to optimize comfort and therapy effect.

  18. Heparin-induced circular dichroism of an achiral, bicyclic species.

    Science.gov (United States)

    Stanley, Floyd E; Warner, Andrew M; McWilliams, Kayla M; Stalcup, Apryll M

    2011-01-01

    Antimalarial drugs have shown potential in suppressing the role of glycosaminoglycans (GAGs) in the pathology of prion protein conformational disorders (e.g. "Mad Cow" disease) by competing for sites of electrostatic interaction. In this study, circular dichroism (CD) and UV/Visible (UV/Vis) absorption spectroscopy techniques were used to investigate the interactions between N-methyl-N'-(7-chloro-4-quinolyl)-1,3-diaminopropane (QD), an achiral, bicyclic compound similar to previously investigated antimalarial drugs, and heparin, a complex GAG that is frequently used as a clinical anticoagulant. Relatively intense heparin-induced CD features were observed for QD and were noted to be radically different from previous studies using related chiral drugs, underscoring the importance of the Pfieffer effect on this and similar heparin research. Additionally, the induced CD for QD was observed to be highly dependent upon drug concentration, heparin concentration, system pH, equilibration time, and ionic strength. These results, in connection with recent work, provide new insight into the nature of the association between GAGs and antimalarial species. PMID:21125690

  19. Bicycle Frame Prediction Techniques with Fuzzy Logic Method

    Directory of Open Access Journals (Sweden)

    Rafiuddin Syam

    2015-03-01

    Full Text Available In general, an appropriate size bike frame would get comfort to the rider while biking. This study aims to predict the simulation system on the bike frame sizes with fuzzy logic. Testing method used is the simulation test. In this study, fuzzy logic will be simulated using Matlab language to test their performance. Mamdani fuzzy logic using 3 variables and 1 output variable intake. Triangle function for the input and output. The controller is designed in the type mamdani with max-min composition and the method deffuzification using center of gravity method. The results showed that height, inseam and Crank Size generating appropriate frame size for the rider associated with comfort. Has a height range between 142 cm and 201 cm. Inseam has a range between 64 cm and 97 cm. Crank has a size range between 175 mm and 180 mm. The simulation results have a range of frame sizes between 13 inches and 22 inches. By using the fuzzy logic can be predicted the size frame of bicycle suitable for the biker.

  20. Innovation and the Interrelatedness of Core Competencies: How Taiwan's Giant Bicycles broke into the US Bicycle Market

    Directory of Open Access Journals (Sweden)

    S. Phineas Upham

    2006-03-01

    Full Text Available I argue that capabilities and barriers to entry are, in certain circumstances, interconnected in such a way that sacrificing one of them can lead to the subsequent vulnerability or erosion of another capability or barrier to entry. I illustrate this through a study of the US bicycle market in the 1980's in general, and Schwinn Corporation and Giant Manufacturing in particular, arguing that both the barriers to entry and the firm capabilities were interrelated. A specific set of decisions by Schwinn had broad and unanticipated effects that went beyond the capacity they explicitly relinquished. In this case manufacturing and distribution were tightly linked in such a way that without some form of tight link between them successful incremental innovation became difficult. Seemingly unrelated capabilities and strengths become mutually reinforcing or interconnected. Instead of being able to choose to add a single capability, or choose to discard one, companies may instead be choosing between sets, groups of interlinked, or patterned capabilities. A seemingly small change may require a major reorganization of other core capabilities that its ostensible status belies.

  1. Evaluating the Safety Effects of Bicycle Lanes in New York City

    Science.gov (United States)

    Srinivasan, Raghavan; McKnight, Claire E.; Ewing, Reid; Roe, Matthew

    2012-01-01

    Objectives. We evaluated the effects of on-street bicycle lanes installed prior to 2007 on different categories of crashes (total crashes, bicyclist crashes, pedestrian crashes, multiple-vehicle crashes, and injurious or fatal crashes) occurring on roadway segments and at intersections in New York City. Methods. We used generalized estimating equation methodology to compare changes in police-reported crashes in a treatment group and a comparison group before and after installation of bicycle lanes. Our study approach allowed us to control confounding factors, such as built environment characteristics, that cannot typically be controlled when a comparison group is used. Results. Installation of bicycle lanes did not lead to an increase in crashes, despite the probable increase in the number of bicyclists. The most likely explanations for the lack of increase in crashes are reduced vehicular speeds and fewer conflicts between vehicles and bicyclists after installation of these lanes. Conclusions. Our results indicate that characteristics of the built environment have a direct impact on crashes and that they should thus be controlled in studies evaluating traffic countermeasures such as bicycle lanes. To prevent crashes at intersections, we recommend installation of “bike boxes” and markings that indicate the path of bicycle lanes across intersections. PMID:22095351

  2. The impact response of traditional and BMX-style bicycle helmets at different impact severities.

    Science.gov (United States)

    DeMarco, Alyssa L; Chimich, Dennis D; Gardiner, John C; Siegmund, Gunter P

    2016-07-01

    Bicycle helmets reduce the frequency and severity of severe to fatal head and brain injuries in bicycle crashes. Our goal here was to measure the impact attenuation performance of common bicycle helmets over a range of impact speeds. We performed 127 drop tests using 13 different bicycle helmet models (6 traditional style helmets and 7 BMX-style helmets) at impact speeds ranging from 1 to 10m/s onto a flat anvil. Helmets were struck on their left front and/or right front areas, a common impact location that was at or just below the test line of most bicycle helmet standards. All but one of the 10 certified helmet models remained below the 300g level at an impact speed of 6m/s, whereas none of the 3 uncertified helmets met this criterion. We found that the helmets with expanded polystyrene liners performed similarly and universally well. The single certified helmet with a polyurethane liner performed below the level expected by the Consumer Product Safety Commission (CPSC) standard at our impact location and the helmet structure failed during one of two supplemental tests of this helmet above the test line. Overall, we found that increased liner thickness generally reduced peak headform acceleration, particularly at higher impact speeds. PMID:27077273

  3. Johnson Space Center's Free Range Bicycle Program.- Fall 2015 Intern Report

    Science.gov (United States)

    Lee-Stockton, Willem

    2015-01-01

    NASA's Johnson Space Center is a big place, encompassing 1,620 acres and more than a hundred buildings. Furthermore, there are reportedly 15 thousand employees, all of which have somewhere to be. To facilitate the movement of all these people JSC has historically relied on human power. Pedaling their way towards deep space, bicycles have been the go to method. Currently there are about 200 Free Range Bicycles at JSC. Free Range Bicycles belong to nobody, except NASA, and are available for anybody to use. They are not to be locked or hidden (although frequently are) and the intention is that there will always be a bike to hop on to get where you're going (although it may not be the bike you rode in on). Although not without its own shortcomings, the Free Range Bicycle Program has continued to provide low cost, simple transportation for NASA's JSC. In addition to the approximately 200 Free Range Bicycles, various larger divisions (like engineering) will often buy a few dozen bikes for their team members to use or individuals will bring their own personal bike to either commute or use on site. When these bicycles fall into disrepair or are abandoned (from retirees etc) they become a problem at JSC. They are an eye sore, create a safety hazard and make it harder to find a working bike in a time of need. The Free Range Program hopes to address this first problem by "tagging out" abandoned or out of service bicycles. A bright orange "DO NOT OPERATE" tag is placed on the bike and given a serial number for tracking purposes. See picture to the right. If the bike has an active owner with intentions to repair the bike the bottom of the tag has instructions for how to claim the abandoned bicycle. After being tagged the owner of the bicycle has 30 days to claim the bicycle and either haul it off site or get it repaired (and labeled) in accordance with Johnson's Bicycle Policy. If the abandoned bicycle is not claimed within 30 days it becomes the property of the Government. The

  4. Lateral Drift Behavior Analysis in Mixed Bicycle Traffic: A Cellular Automaton Model Approach

    Directory of Open Access Journals (Sweden)

    Xue Feng

    2016-01-01

    Full Text Available Bicycle movements are always associated with lateral drifts. However, the impacts of lateral drift behavior, as well as variable lateral clearance maintaining behavior due to the variation of drift intensity, on mixed bicycle flow are not clear. This paper establishes a new cellular automata model to study typical characteristics of mixed bicycle traffic induced by lateral drift and its accompanying behavior. Based on derived positive correlation between passing speed and drift speed through survey, the occurrence probability of lateral drift and the degree of maintained lateral clearance are both introduced in accordance with the variance of passing speed. Then, in whole density region, firm conformity between simulation results and actual survey data is reached, which has seldom been achieved in previous studies. It is further verified that speed distortions in intermediate and high density region induced by assumption of constant lateral clearance requirements can be revised by introducing its variability characteristics. In addition, two contrastive impacts of lateral drift behavior are observed. That is, it causes speed fluctuation in low density while alleviating the speed fluctuation in relatively high density. These results are expected to be helpful to improve the simulation performance of mixed bicycle flow as well as depict more realistic vehicle-bicycle conflicts and so on.

  5. Bicycle accident-related head injuries in India

    Directory of Open Access Journals (Sweden)

    Ashok Munivenkatappa

    2013-01-01

    Full Text Available Objectives: To describe the epidemiology of head injuries sustained due to bicycle accidents in India. Materials and Methods: Data were retrospectively collected over a period of six months (15 May 2011 to 15 November 2011. Demography of patients, Glasgow coma scale (GCS, clinical and imaging findings, and mortality and outcome using Glasgow outcome scale (GOS, Rivermead post-concussion symptom questionnaire (RPCSQ and Rivermead head injury follow-up questionnaire (RHFUQ, were analyzed. Outcome was assessed by telephonic interview. Results: There were 108 patients (100 males with mean age of 27.7 years. Seventy-four (68.5% were from rural areas. Accidents due to vehicular collision accounted for 60 (55.6% cases. None wore a helmet. The admission GCS was 14-15 in 68.5% cases, 13-3 in 31.5%. The risk of moderate to severe injuries was increased among working laborers (OR = 5, and patients with loss of consciousness (OR = 4. Sixty-three (49% patients had abnormal computed tomography (CT findings; most common finding was skull fracture 25 (23.1%. Four patients needed surgery. The GOS assessment at three to six months revealed favorable outcome in 66 patients (61.1% and death in 8 (7.4%. The common post-concussion symptoms were headache, fatigue, and poor concentration. Conclusion: The majority of hospitalized cyclists were from a rural background and of the lower income group. After three months the majority of patients had good recovery with few persistent concussion symptoms.

  6. Synthetic strategy for bicyclic tetrapeptides HDAC inhibitors using ring closing metathesis

    Indian Academy of Sciences (India)

    Md Nurul Islam; Md Shahidul Islam; Md Ashraful Hoque; Tamaki Kato; Norikazu Nishino

    2015-09-01

    Cyclic peptides show diverse biological activities and are considered as good therapeutic agents due to structural rigidity, receptor selectivity and biochemical stability. We have developed bicyclic tetrapeptide HDAC inhibitors based on different cyclic tetrapeptide scaffolds. For the synthesis of these bicyclic tetrapeptides, two cyclization steps, namely, peptide cyclization and fusion of aliphatic side chains by ring closing metathesis (RCM) were involved. In the course of these syntheses, we have established two facts: a lower limit of aliphatic loop length and better synthetic route for bicyclic tetrapeptide synthesis. It was found that nine methylene loop length is the lower limit for aliphatic loop and the synthetic route selection depended on the configuration of amino acids in the cyclic tetrapeptide scaffold. RCM followed by peptide cyclization was the proper route for LDLD configuration and the reverse route was suitable for LLLD configuration.

  7. Conversion Of An Ordinary N Bicycle Into An Electric Bike And Related Research

    Directory of Open Access Journals (Sweden)

    Marius Janavičius

    2014-05-01

    Full Text Available An electric bicycle as a transport and leisure vehicle is expected to have a promising future. Currently, he market offers a great choice of factory electric bicycles and conversion kits to remake an ordinary bicycle into an electric bike. Also, the increasing number of electric vehicles is determined by the reduction in costs for manufacturing of batteries and an evolution in battery technology. This article presents the implementation of an electric bike by selecting the “Golden Motor Technology” company’s electric front wheel conversion kit MagicPie3 and 16 cell 10Ah LiFePO4 battery. After installation of the engine and other components, experiments were conducted to evaluate the performance characteristics of the electric bike and check the manufacturer’s specifications.

  8. Study of the health effects of bicycling in an urban atmosphere. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Waldman, M.; Weiss, S.; Articola, W.

    1977-10-14

    This report analyzes data on the health effects of bicycling in an urban environment through intensive study of ten healthy male subjects bicycling or driving in systematically varied conditions in the streets of Washington, D.C. Evaluation criteria for available technology and instrumentation are included and a methodology is developed for route selection. Specific air pollutants (carbon monoxide, ozone, sulfates, nitrates, and particulates) are measured concurrently with exposure and subsequent changes in health status identified through pulmonary function testing, cardiovascular testing, and blood and symptoms analysis. The report concludes that no major adverse short-term health effects were noted for ten healthy male subjects while bicycling or driving in levels of pollution and thermal stress encountered during the study period. Recommendations for further research are also presented.

  9. Association between neighborhood walkability and GPS-measured walking, bicycling and vehicle time in adolescents

    DEFF Research Database (Denmark)

    Carlson, Jordan A.; Saelens, Brian E.; Kerr, Jacqueline;

    2015-01-01

    Objectives: To investigate relations of walking, bicycling and vehicle time to neighborhood walkability and total physical activity in youth. Methods: Participants (N=690) were from 380 census block groups of high/low walkability and income in two US regions. Home neighborhood residential density......, intersection density, retail density, entertainment density and walkability were derived using GIS. Minutes/day of walking, bicycling and vehicle time were derived from processing algorithms applied to GPS. Accelerometers estimated total daily moderate-to-vigorous physical activity (MVPA). Models were adjusted...... for nesting of days (N=2987) within participants within block groups. Results: Walking occurred on 33%, active travel on 43%, and vehicle time on 91% of the days observed. Intersection density and neighborhood walkability were positively related to walking and bicycling and negatively related to vehicle time...

  10. The spatio-temporal Development of Copenhagen's bicycle infrastructure 1912-2013

    DEFF Research Database (Denmark)

    Carstensen, Trine Agervig; Olafsson, Anton Stahl; Bech, Nynne Marie;

    2015-01-01

    Cycling plays an important role in low-carbon transitions. Around the globe, cities are constructing bicycle infrastructure. The city of Copenhagen has a bicycle-friendly infrastructure celebrated for its fine-meshed network. This study documents the spatio-temporal development of Copenhagen....... In search for identifying drivers, the study analyses the city’s spatial growth pattern, migration pattern, development of road network and changes in the transport culture. Analyses reveal that the bicycle infrastructure expanded at a relatively constant pace during distinct periods of urban transformation...... and safety (first cycling city); the flow for cars (car city); urban liveability for soft transport (liveable city); and, finally, to improve the flow for cyclists as part a strategic re-design of urban space (liveable cycling city)....

  11. The effects of operating a touch screen smartphone and other common activities performed while bicycling on cycling behaviour

    NARCIS (Netherlands)

    de Waard, Dick; Lewis Evans, Ben; Jelijs, Bart; Tucha, Oliver; Brookhuis, Karel

    2014-01-01

    Although it has been shown that making phone calls or sending text messages while riding a bicycle can have a negative impact on bicyclist’s behaviour, in countries such as the Netherlands the operation of a mobile phone while cycling on a bicycle is not illegal and is actually quite common. In rece

  12. The role of bicycle sharing systems in normalising the image of cycling: An observational study of London cyclists

    Science.gov (United States)

    Goodman, Anna; Green, Judith; Woodcock, James

    2014-01-01

    Bicycle sharing systems are increasingly popular around the world and have the potential to increase the visibility of people cycling in everyday clothing. This may in turn help normalise the image of cycling, and reduce perceptions that cycling is ‘risky’ or ‘only for sporty people’. This paper sought to compare the use of specialist cycling clothing between users of the London bicycle sharing system (LBSS) and cyclists using personal bicycles. To do this, we observed 3594 people on bicycles at 35 randomly-selected locations across central and inner London. The 592 LBSS users were much less likely to wear helmets (16% vs. 64% among personal-bicycle cyclists), high-visibility clothes (11% vs. 35%) and sports clothes (2% vs. 25%). In total, 79% of LBSS users wore none of these types of specialist cycling clothing, as compared to only 30% of personal-bicycle cyclists. This was true of male and female LBSS cyclists alike (all p>0.25 for interaction). We conclude that bicycle sharing systems may not only encourage cycling directly, by providing bicycles to rent, but also indirectly, by increasing the number and diversity of cycling ‘role models’ visible. PMID:25568838

  13. Outcomes of Home-Support Consultation on the Maintenance of Bicycle-Riding Skills for Youth with Autism Spectrum Disorder

    Science.gov (United States)

    Reynolds, Jennifer L.; Pitchford, E. Andrew; Hauck, Janet L.; Ketcheson, Leah R.; Ulrich, Dale A.

    2016-01-01

    Bicycle riding is a functional motor skill that increases physical activity opportunities, social interaction, and independence. However, bicycle riding is difficult for youth with autism spectrum disorder (ASD) to learn. This study examined the effectiveness of home-support consultation (HSC) on increasing the maintenance of independent bicycle…

  14. Perceiving and Acting on Complex Affordances: How Children and Adults Bicycle across Two Lanes of Opposing Traffic

    Science.gov (United States)

    Grechkin, Timofey Y.; Chihak, Benjamin J.; Cremer, James F.; Kearney, Joseph K.; Plumert, Jodie M.

    2013-01-01

    This investigation examined how children and adults negotiate a challenging perceptual-motor problem with significant real-world implications--bicycling across two lanes of opposing traffic. Twelve- and 14-year-olds and adults rode a bicycling simulator through an immersive virtual environment. Participants crossed intersections with continuous…

  15. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams

    Science.gov (United States)

    Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Chris A.; Bi, Danse; Basha, Fatima Z.; Hanson, Paul R.

    2013-01-01

    The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several additional cyclization strategies have been realized enabling access to new bicyclic sultams. PMID:24385680

  16. Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.

    Science.gov (United States)

    Cromm, Philipp M; Schaubach, Sebastian; Spiegel, Jochen; Fürstner, Alois; Grossmann, Tom N; Waldmann, Herbert

    2016-01-01

    Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic peptide architectures is limited due to a lack of appropriate orthogonal ring-closing reactions. Here, we report chemically orthogonal ring-closing olefin (RCM) and alkyne metathesis (RCAM), which enable an efficient chemo- and regioselective synthesis of complex bicyclic peptide scaffolds with variable macrocycle geometries. We also demonstrate that the formed alkyne macrocycle can be functionalized subsequently. The orthogonal RCM/RCAM system was successfully used to evolve a monocyclic peptide inhibitor of the small GTPase Rab8 into a bicyclic ligand. This modified peptide shows the highest affinity for an activated Rab GTPase that has been reported so far. The RCM/RCAM-based formation of bicyclic peptides provides novel opportunities for the design of bioactive scaffolds suitable for the modulation of challenging protein targets. PMID:27075966

  17. Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.

    Science.gov (United States)

    Cromm, Philipp M; Schaubach, Sebastian; Spiegel, Jochen; Fürstner, Alois; Grossmann, Tom N; Waldmann, Herbert

    2016-04-14

    Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic peptide architectures is limited due to a lack of appropriate orthogonal ring-closing reactions. Here, we report chemically orthogonal ring-closing olefin (RCM) and alkyne metathesis (RCAM), which enable an efficient chemo- and regioselective synthesis of complex bicyclic peptide scaffolds with variable macrocycle geometries. We also demonstrate that the formed alkyne macrocycle can be functionalized subsequently. The orthogonal RCM/RCAM system was successfully used to evolve a monocyclic peptide inhibitor of the small GTPase Rab8 into a bicyclic ligand. This modified peptide shows the highest affinity for an activated Rab GTPase that has been reported so far. The RCM/RCAM-based formation of bicyclic peptides provides novel opportunities for the design of bioactive scaffolds suitable for the modulation of challenging protein targets.

  18. Risky riding: Naturalistic methods comparing safety behavior from conventional bicycle riders and electric bike riders.

    Science.gov (United States)

    Langford, Brian Casey; Chen, Jiaoli; Cherry, Christopher R

    2015-09-01

    As electric bicycles (e-bikes) have emerged as a new transportation mode, their role in transportation systems and their impact on users have become important issues for policy makers and engineers. Little safety-related research has been conducted in North America or Europe because of their relatively small numbers. This work describes the results of a naturalistic GPS-based safety study between regular bicycle (i.e., standard bicycle) and e-bike riders in the context of a unique bikesharing system that allows comparisons between instrumented bike technologies. We focus on rider safety behavior under four situations: (1) riding in the correct direction on directional roadway segments, (2) speed on on-road and shared use paths, (3) stopping behavior at stop-controlled intersections, and (4) stopping behavior at signalized intersections. We find that, with few exceptions, riders of e-bike behave very similarly to riders of bicycles. Violation rates were very high for both vehicles. Riders of regular bicycles and e-bikes both ride wrong-way on 45% and 44% of segments, respectively. We find that average on-road speeds of e-bike riders (13.3kph) were higher than regular bicyclists (10.4kph) but shared use path (greenway) speeds of e-bike riders (11.0kph) were lower than regular bicyclists (12.6kph); both significantly different at >95% confidence. At stop control intersections, both bicycle and e-bike riders violate the stop signs at the similar rate with bicycles violating stop signs at a slightly higher rate at low speed thresholds (∼80% violations at 6kph, 40% violations at 11kph). Bicycles and e-bikes violate traffic signals at similar rates (70% violation rate). These findings suggest that, among the same population of users, e-bike riders exhibit nearly identical safety behavior as regular bike riders and should be regulated in similar ways. Users of both technologies have very high violation rates of traffic control devices and interventions should occur to

  19. The Feasibility of Wood and its Derivatives as a Bicycle Frame Building Material

    OpenAIRE

    BRENT TAYLOR, NICHOLAS

    2016-01-01

    [EN] ABSTRACT Nicholas Brent Taylor: The Feasibility of Wood and its Derivatives as a Bicycle Frame Building Material The bicycle is often considered as one of the most important inventions of all time. In addition, it is the most efficient form of human transport in the world. It is non pollutant, uses no fuel other than human power and its carbon footprint is neutralised in a short time. Today, faced with the threat of global warming brought about by fossil fuels, countries such as De...

  20. Device and method to determine perineal artery occlusion during road bicycling.

    Science.gov (United States)

    Parthiban, Sujeeth; Hotaling, James M; Ohlander, Samuel J; Baftiri, Amit P; Freels, Sally; Niederberger, Craig S

    2014-01-01

    Greater than 60 million American men who ride bicycles are at risk of developing erectile dysfunction. One possible reason is occlusion of the perineal arteries. Researchers relied on indirect methods and stationary models to study this problem. We developed a novel system to quantify occlusion among bicycle riders during a road bike ride. Our verification and validation activities show that this system can be safely used on human subjects to measure perineal artery occlusion. The method described in this paper provides a valuable tool to the researchers to study or to develop new solutions that alleviate this problem. The outcomes of these efforts will help millions of cyclists worldwide. PMID:25570811

  1. Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

    OpenAIRE

    Lakshminarayana, Suresh B.; Helena I M Boshoff; Joseph Cherian; Sindhu Ravindran; Anne Goh; Jan Jiricek; Mahesh Nanjundappa; Amit Nayyar; Meera Gurumurthy; Ramandeep Singh; Thomas Dick; Francesca Blasco; Barry, Clifton E.; Ho, Paul C.; Manjunatha, Ujjini H

    2014-01-01

    PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during which the free drug concentrations in plasma are above the MIC (fT>MIC ). In this study, a panel of closely related potent bicyclic 4-nitroimidazoles was profiled in both in vivo PK and efficacy studies. In an established murine TB model, the eff...

  2. Mapping cyclist activity and injury risk in a network combining smartphone GPS data and bicycle counts.

    Science.gov (United States)

    Strauss, Jillian; Miranda-Moreno, Luis F; Morency, Patrick

    2015-10-01

    In recent years, the modal share of cycling has been growing in North American cities. With the increase of cycling, the need of bicycle infrastructure and road safety concerns have also raised. Bicycle flows are an essential component in safety analysis. The main objective of this work is to propose a methodology to estimate and map bicycle volumes and cyclist injury risk throughout the entire network of road segments and intersections on the island of Montreal, achieved by combining smartphone GPS traces and count data. In recent years, methods have been proposed to estimate average annual daily bicycle (AADB) volume and injury risk estimates at both the intersection and segment levels using bicycle counts. However, these works have been limited to small samples of locations for which count data is available. In this work, a methodology is proposed to combine short- and long-term bicycle counts with GPS data to estimate AADB volumes along segments and intersections in the entire network. As part of the validation process, correlation is observed between AADB values obtained from GPS data and AADB values from count data, with R-squared values of 0.7 for signalized intersections, 0.58 for non-signalized intersections and between 0.48 and 0.76 for segments with and without bicycle infrastructure. The methodology is also validated through the calibration of safety performance functions using both sources of AADB estimates, from counts and from GPS data. Using the validated AADB estimates, the factors associated with injury risk were identified using data from the entire population of intersections and segments throughout Montreal. Bayesian injury risk maps are then generated and the concentrations of expected injuries and risk at signalized intersections are identified. Signalized intersections, which are often located at the intersection of major arterials, witness 4 times more injuries and 2.5 times greater risk than non-signalized intersections. A similar

  3. Bicycle-related genitourinary injuries in the USA from 2002–2010

    Science.gov (United States)

    Tasian, Gregory E; Appa, Ayesha A; Bagga, Herman S; Blaschko, Sarah; McCulloch, Charles E; McAninch, Jack W; Breyer, Benjamin N

    2014-01-01

    Among children, the incidence of bicycle-related genitourinary (GU) injuries was 448 per 100 000 (95% CI 383 to 514) and, among adults, was 53 per 100 000 (95% CI 36 to 71). Although children sustained more injuries, adults were more likely to being admitted to the hospital for the GU injury (OR 1.95, 95% CI 1.13 to 3.37). Children sustain nearly 10 times more GU injuries due to bicycles than adults, but adults have higher odds of sustaining injuries requiring admission. PMID:24618096

  4. Risky riding: Naturalistic methods comparing safety behavior from conventional bicycle riders and electric bike riders.

    Science.gov (United States)

    Langford, Brian Casey; Chen, Jiaoli; Cherry, Christopher R

    2015-09-01

    As electric bicycles (e-bikes) have emerged as a new transportation mode, their role in transportation systems and their impact on users have become important issues for policy makers and engineers. Little safety-related research has been conducted in North America or Europe because of their relatively small numbers. This work describes the results of a naturalistic GPS-based safety study between regular bicycle (i.e., standard bicycle) and e-bike riders in the context of a unique bikesharing system that allows comparisons between instrumented bike technologies. We focus on rider safety behavior under four situations: (1) riding in the correct direction on directional roadway segments, (2) speed on on-road and shared use paths, (3) stopping behavior at stop-controlled intersections, and (4) stopping behavior at signalized intersections. We find that, with few exceptions, riders of e-bike behave very similarly to riders of bicycles. Violation rates were very high for both vehicles. Riders of regular bicycles and e-bikes both ride wrong-way on 45% and 44% of segments, respectively. We find that average on-road speeds of e-bike riders (13.3kph) were higher than regular bicyclists (10.4kph) but shared use path (greenway) speeds of e-bike riders (11.0kph) were lower than regular bicyclists (12.6kph); both significantly different at >95% confidence. At stop control intersections, both bicycle and e-bike riders violate the stop signs at the similar rate with bicycles violating stop signs at a slightly higher rate at low speed thresholds (∼80% violations at 6kph, 40% violations at 11kph). Bicycles and e-bikes violate traffic signals at similar rates (70% violation rate). These findings suggest that, among the same population of users, e-bike riders exhibit nearly identical safety behavior as regular bike riders and should be regulated in similar ways. Users of both technologies have very high violation rates of traffic control devices and interventions should occur to

  5. Relationship between Locations of Facial Injury and the Use of Bicycle Helmets: A Systematic Review.

    Science.gov (United States)

    Hwang, Kun; Jeon, Yun Moon; Ko, Yeong Seung; Kim, Yeon Soo

    2015-07-01

    The aim of this study is to review the protective effect of a bicycle helmet on each facial location systematically. PubMed was searched for articles published before December 12, 2014. The data were summarized, and the odds ratio (OR) between the locations of facial injury was calculated. A statistical analysis was performed with Review Manager (The Nordic Cochrane Centre). Bicycle helmets protect the upper and middle face from serious facial injury but do not protect the lower face. Non-wearers had significantly increased risks of upper facial injury (OR, 2.07; Pchin cap might decrease the risk of lower facial injury.

  6. Aminocyclopentanols as sugar mimics. Synthesis from unsaturated bicyclic lactones by Overman rearrangement

    DEFF Research Database (Denmark)

    Bøjstrup, Marie; Fanefjord, Mette; Lundt, Inge

    2007-01-01

    Bicyclic cyclopentane lactones, prepared from bromodeoxyaldonolactones, were transformed into aminocyclopentanols with an Overman rearrangement as the key step. Two of the compounds prepared, 7 and 19, were found to be good inhibitors of jack bean alpha-mannosidase and beta-D-N-acetylglucosaminid......Bicyclic cyclopentane lactones, prepared from bromodeoxyaldonolactones, were transformed into aminocyclopentanols with an Overman rearrangement as the key step. Two of the compounds prepared, 7 and 19, were found to be good inhibitors of jack bean alpha-mannosidase and beta...

  7. Knights of death: introducing bicycles and motor vehicles to Turin, 1890-1907.

    Science.gov (United States)

    Moraglio, Massimo

    2015-04-01

    The aim of this article is to investigate, through a case study from the city of Turin, the reaction to the arrival of bicycles and automobiles in Italy. It focuses on the early years of bicycle and automobile use, using municipal council minutes, local newspapers, and satirical magazines as sources. The introduction of velocipedes and cars disrupted the traditional use of roads as public spaces, generating protests against the new transport devices, especially with regard to safety concerns resulting from the transgression of traditional uses of urban streets, the speed of vehicles, and the anonymity of riders and drivers. PMID:26005084

  8. 16 CFR Figure 1 to Part 1512 - Bicycle Front Fork Cantilever Bending Test Rig

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Bicycle Front Fork Cantilever Bending Test Rig 1 Figure 1 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS... Fork Cantilever Bending Test Rig EC03OC91.070...

  9. Use of automated video analysis for the evaluation of bicycle movement and interaction

    Science.gov (United States)

    Twaddle, Heather; Schendzielorz, Tobias; Fakler, Oliver; Amini, Sasan

    2014-03-01

    With the purpose of developing valid models of microscopic bicycle behavior, a large quantity of video data is collected at three busy urban intersections in Munich, Germany. Due to the volume of data, the manual processing of this data is infeasible and an automated or semi-automated analysis method must be implemented. An open source software, "Traffic Intelligence", is used and extended to analyze the collected video data with regard to research questions concerning the tactical behavior of bicyclists. In a first step, the feature detection parameters, the tracking parameters and the object grouping parameters are calibrated, making it possible to accurately track and group the objects at intersections used by large volumes of motor vehicles, bicycles and pedestrians. The resulting parameters for the three intersections are presented. A methodology for the classification of road users as cars, bicycles or pedestrians is presented and evaluated. This is achieved by making hypotheses about which features belong to cars, or bicycles and pedestrians, and using grouping parameters specified for that road user group to cluster the features into objects. These objects are then classified based on their dynamic characteristics. A classification structure for the maneuvers of different road users is presented and future applications are discussed.

  10. The Effects of Prompting and Reinforcement on Safe Behavior of Bicycle and Motorcycle Riders

    Science.gov (United States)

    Okinaka, Takeru; Shimazaki, Tsuneo

    2011-01-01

    A reversal design was used to evaluate the effects of vocal and written prompts as well as reinforcement on safe behavior (dismounting and walking bicycles or motorcycles on a sidewalk) on a university campus. Results indicated that an intervention that consisted of vocal and written prompts and reinforcement delivered by security guards was…

  11. A Study of Bicycle and Passenger Car Collisions Based on Insurance Claims Data

    Science.gov (United States)

    Isaksson-Hellman, Irene

    2012-01-01

    In Sweden, bicycle crashes are under-reported in the official statistics that are based on police reports. Statistics from hospital reports show that cyclists constitute the highest percentage of severely injured road users compared to other road user groups. However, hospital reports lack detailed information about the crash. To get a more comprehensive view, additional data are needed to accurately reflect the casualty situation for cyclists. An analysis based on 438 cases of bicycle and passenger car collisions is presented, using data collected from insurance claims. The most frequent crash situations are described with factors as to where and when collisions occur, age and gender of the involved cyclists and drivers. Information on environmental circumstances such as road status, weather- and light conditions, speedlimits and traffic environment is also included. Based on the various crash events, a total of 32 different scenarios have been categorized, and it was found that more than 75% were different kinds of intersection related situations. From the data, it was concluded that factors such as estimated impact speed and age significantly influence injury severity. The insurance claims data complement the official statistics and provide a more comprehensive view of bicycle and passenger car collisions by considering all levels of crash and injury severity. The detailed descriptions of the crash situations also provide an opportunity to find countermeasures to prevent or mitigate collisions. The results provide a useful basis, and facilitates the work of reducing the number of bicycle and passenger car collisions with serious consequences. PMID:23169111

  12. Macroscopic modeling of pedestrian and bicycle crashes: A cross-comparison of estimation methods.

    Science.gov (United States)

    Amoh-Gyimah, Richard; Saberi, Meead; Sarvi, Majid

    2016-08-01

    The paper presents a cross-comparison of different estimation methods to model pedestrian and bicycle crashes. The study contributes to macro level safety studies by providing further methodological and empirical evidence on the various factors that influence the frequency of pedestrian and bicycle crashes at the planning level. Random parameter negative binomial (RPNB) models are estimated to explore the effects of various planning factors associated with total, serious injury and minor injury crashes while accounting for unobserved heterogeneity. Results of the RPNB models were compared with the results of a non-spatial negative binomial (NB) model and a Poisson-Gamma-CAR model. Key findings are, (1) the RPNB model performed best with the lowest mean absolute deviation, mean squared predicted error and Akaiki information criterion measures and (2) signs of estimated parameters are consistent if these variables are significant in models with the same response variables. We found that vehicle kilometers traveled (VKT), population, percentage of commuters cycling or walking to work, and percentage of households without motor vehicles have a significant and positive correlation with the number of pedestrian and bicycle crashes. Mixed land use is also found to have a positive association with the number of pedestrian and bicycle crashes. Results have planning and policy implications aimed at encouraging the use of sustainable modes of transportation while ensuring the safety of pedestrians and cyclist. PMID:27209153

  13. Tertiary Student Attitudes to Bicycle Commuting in a Regional Australian University

    Science.gov (United States)

    Whannell, Patricia; Whannell, Robert; White, Richard

    2012-01-01

    Purpose: The purpose of this paper is to provide executive management at a regional university with empirical data to justify, or otherwise, a substantial outlay of funds to support bicycle commuting as a viable strategy for the reduction of traffic congestion. Design/methodology/approach: A custom designed questionnaire was completed by 270…

  14. [Changes in ECG indicators during bicycle ergometry in patients having suffered myocardial infarction].

    Science.gov (United States)

    Kheifets, Z N

    1984-01-01

    Altogether 218 patients with a history of myocardial infarction were subjected to bicycle ergometry. The ECG recorded at the height of the exercise showed a significant increase in the heart rate and in the amplitudes of P and R waves. The diastole and electric systole shortened. As the load was raised, the rate of A-B conduction was relatively decelerated.

  15. Modeling Mixed Bicycle Traffic Flow: A Comparative Study on the Cellular Automata Approach

    Directory of Open Access Journals (Sweden)

    Dan Zhou

    2015-01-01

    Full Text Available Simulation, as a powerful tool for evaluating transportation systems, has been widely used in transportation planning, management, and operations. Most of the simulation models are focused on motorized vehicles, and the modeling of nonmotorized vehicles is ignored. The cellular automata (CA model is a very important simulation approach and is widely used for motorized vehicle traffic. The Nagel-Schreckenberg (NS CA model and the multivalue CA (M-CA model are two categories of CA model that have been used in previous studies on bicycle traffic flow. This paper improves on these two CA models and also compares their characteristics. It introduces a two-lane NS CA model and M-CA model for both regular bicycles (RBs and electric bicycles (EBs. In the research for this paper, many cases, featuring different values for the slowing down probability, lane-changing probability, and proportion of EBs, were simulated, while the fundamental diagrams and capacities of the proposed models were analyzed and compared between the two models. Field data were collected for the evaluation of the two models. The results show that the M-CA model exhibits more stable performance than the two-lane NS model and provides results that are closer to real bicycle traffic.

  16. Design of an aluminium bicycle path integrated in a steel bridge

    NARCIS (Netherlands)

    Maljaars, J.; Soetens, F.; Burggraaf, H.G.

    2007-01-01

    This paper describes the design of the aluminium structure of a bicycle path which is mounted on an existing steel brige. The benefits of aluminium, being low self weight, freedom in design obtained by extrusion and good corrosion resistance were maximal utilized. One of the main drawbacks of alumin

  17. Sensor design for outdoor racing bicycle field testing for human vibration comfort evaluation

    International Nuclear Information System (INIS)

    This paper is concerned with the vibrational comfort evaluation of the cyclist when cycling a rough surface. Outdoor comfort tests have so far only been done through instrumenting the bicycle with accelerometers. This work instruments a racing bicycle with custom-made contact force sensors and velocity sensors to acquire human comfort through the absorbed power method. Comfort evaluation is assessed at the hand–arm and seat interface of the cyclist with the bicycle. By means of careful finite-element analysis for designing the force gauges at the handlebar and the seat combined with precise calibration of both force and velocity sensors, all sensors have proven to work properly. Initial field tests are focused on the proper functioning of the designed sensors and their suitability for vibration comfort measurements. Tests on a cobblestone road reveal that the outcome of the absorbed power values is within the same range as those from laboratory tests found in the literature. This sensor design approach for outdoor testing with racing bicycles may give a new interpretation on evaluating the cyclist's comfort since the vibrational load is not only quantified in terms of acceleration but also in terms of force and velocity at the bicycle–cyclist contact points. (paper)

  18. Road safety and bicycle usage impacts of unbundling vehicular and cycle traffic in Dutch urban networks.

    NARCIS (Netherlands)

    Schepers, P. Heinen, E. Methorst, R. & Wegman, F.

    2015-01-01

    Bicycle-motor vehicle crashes are concentrated along distributor roads where cyclists are exposed to greater volumes of high-speed motorists than they would experience on access roads. This study examined the road safety impact of network-level separation of vehicular and cycle traffic in Dutch urba

  19. Road safety and bicycle usage impacts of unbundling vehicular and cycle traffic in Dutch urban networks

    NARCIS (Netherlands)

    Schepers, P.; Heinen, E.; Methorst, R.; Wegman, F.C.M.

    2013-01-01

    Bicycle-motor vehicle crashes are concentrated along distributor roads where cyclists are exposed to greater volumes of high-speed motorists than they would experience on access roads. This study examined the road safety impact of network-level separation of vehicular and cycle traffic in Dutch urba

  20. Balance and control of a rear-wheel steered speed-record recumbent bicycle

    NARCIS (Netherlands)

    Schwab, A.L.; Kooijman, J.D.G.

    2014-01-01

    The goal of the Human Power Team from the TU Delft and the Free University of Amsterdam is to break the world speed record in unpaced cycling (Sam Whittingham, 133.28 km/h). The design of such a faired recumbent bicycle is a challenge. The Delft design, called VeloX (Human Power Team (2013)), is a f

  1. Building the fastest bicycle in the world; a year with the Human Power Team Delft & Amsterdam

    NARCIS (Netherlands)

    Schuurman, M.; Roks, G.

    2014-01-01

    “Third time lucky” is the saying, but for the third Human Power Team it almost turned out as a year for nothing. The team has been attempting to set the world record for the fastest bicycle powered only by human muscles for two years already. This endeavor to let a Dutchman be the fastest human on e

  2. Assessing and Prioritizing bicycle projects in Denmark: the CPP-Model

    DEFF Research Database (Denmark)

    Salling, Kim Bang

    2011-01-01

    billion DKK in the period from 2009-2014. This presentation will mainly focus upon the modelling aspect of the prioritization of different bicycle applications for the funds and the experiences from the latter. Accordingly, the modelling approach is based upon the collaborative work between the Technical...

  3. Comparison of dipyridamole-handgrip test and bicycle exercise test for thallium tomographic imaging

    Energy Technology Data Exchange (ETDEWEB)

    Huikuri, H.V.; Korhonen, U.R.; Airaksinen, J.; Ikaeheimo, M.J.H.; Heikkilae, J.T.; Takkunen, J.T.

    1988-02-01

    Seventy-three patients with angina pectoris and 20 with atypical chest pain, who underwent coronary angiography, were examined by single-photon emission computed thallium tomography (TI-SPECT) using a combined dipyridamole-handgrip stress test. Perfusion defects were detected in 78 of 81 patients with angiographically significant coronary artery disease (CAD) (sensitivity 96%). In 9 of 12 patients without CAD, the thallium images were normal (specificity 75%). Thirty-five patients with CAD were reexamined by TI-SPECT using a dynamic bicycle exercise stress test. The sensitivity of the dipyridamole-handgrip test did not differ from the bicycle exercise test in diagnosing the CAD (97% vs 94%). Multiple thallium defects were seen in 19 of 22 (86%) patients with multivessel CAD by the dipyridamole-handgrip test but only in 14 of 22 (64%) by the bicycle exercise test. Noncardiac side-effects occurred in 17 of 93 (18%) patients after dipyridamole infusion. Cardiac symptoms were less common during the dipyridamole-handgrip test than during the bicycle exercise (15% vs 76%, p less than 0.01). These data suggest that the dipyridamole-handgrip test is a useful alternative stress method for thallium perfusion imaging, particularly in detecting multivessel CAD.

  4. 77 FR 60050 - Special Regulations; Areas of the National Park System, Saguaro National Park, Bicycling

    Science.gov (United States)

    2012-10-02

    ... and adopted by NPS leadership after an adequate analysis of the benefits, impacts, and economic cost... Hope Camp Trail as a bicycle route within Saguaro National Park (77 FR 12761). The proposed rule was... solitude and wilderness-like aesthetics that are long-standing attributes in this area and the primary...

  5. Sandia bicycle commuters group -- pollution prevention at Sandia National Laboratories, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Wrons, R.

    1998-06-01

    The Sandia Bicycle Commuters Group (SBCG) formed three years ago for the purpose of addressing issues that impact the bicycle commuting option. The meeting that launched the SBCG was scheduled in conjunction with National Bike-to-Work day in May 1995. Results from a survey handed out at the meeting solidly confirmed the issues and that an advocacy group was needed. The purpose statement for the Group headlines its web site and brochure: ``Existing to assist and educate the SNL workforce bicyclist on issues regarding Kirtland Air Force Base (KAFB) access, safety and bicycle-supporting facilities, in order to promote bicycling as an effective and enjoyable means of commuting.`` The SNL Pollution Prevention (P2) Team`s challenge to the SNL workforce is to ``prevent pollution, conserve natural resources, and save money``. In the first winter of its existence, the SBCG sponsored a winter commute contest in conjunction with the City`s Clean Air Campaign (CAC). The intent of the CAC is to promote alternative (to the single-occupant vehicle) commuting during the Winter Pollution Advisory Period (October 1--February 28), when the City runs the greatest risk of exceeding federal pollution limits.

  6. THE EFFECTS OF SURFACE-INDUCED LOADS ON FOREARM MUSCLE ACTIVITY DURING STEERING A BICYCLE

    Directory of Open Access Journals (Sweden)

    Pinar Arpinar-Avsar

    2013-09-01

    Full Text Available On the bicycle, the human upper extremity has two essential functions in steering the bicycle and in supporting the body. Through the handlebar, surface- induced loads are transmitted to the hand and arm of the bicycle rider under vibration exposure conditions. Thus, the purpose of the study was to investigate the effect of vibration exposure on forearm muscle activity for different road surfaces (i.e. smooth road, concrete stone pavement, rough road and for different bicycles. Ten subjects participated in experiments and two types of bicycles, i.e. Road Bike (RB and Mountain Bike (MTB are compared. The acceleration magnitudes were dominant along x and z-axes. The r.m.s acceleration values in the z direction at the stem of MTB were at most 2.56, 7.04 and 10.76 m·s-2 when pedaling respectively on asphalt road, concrete pavement and rough road. In the case of RB the corresponding values were respectively 4.43, 11.75 and 27.31 m·s-2. The cumulative normalized muscular activity levels during MTB trials on different surfaces had the same tendency as with acceleration amplitudes and have ranked in the same order from lowest to highest value. Although road bike measurements have resulted in a similar trend of increment, the values computed for rough road trials were higher than those in MTB trials. During rough road measurements on MTB, rmsEMG of extensor muscles reached a value corresponding to approximately 50% of MVC (Maximum Voluntary Contraction. During RB trials performed on rough road conditions, rmsEMG (%MVC values for the forearm flexor muscles reached 45.8% of their maximal. The level of muscular activity of forearm muscles in controlling handlebar movements has been observed to be enhanced by the increase in the level of vibration exposed on the bicycle. Since repeated forceful gripping and pushing forces to a handle of a vibratory tool can create a risk of developing circulatory, neurological, or musculoskeletal disorder, a bicycle rider

  7. Impact Evaluation of a Public Bicycle Share Program on Cycling: A Case Example of BIXI in Montreal, Quebec

    Science.gov (United States)

    Gauvin, Lise; Kestens, Yan; Fournier, Michel; Morency, Patrick; Drouin, Louis

    2013-01-01

    Objectives. We examined associations between residential exposure to BIXI (BIcycle-taXI)—a public bicycle share program implemented in Montreal, Quebec, in 2009, which increases accessibility to cycling by making available 5050 bicycles at 405 bicycle docking stations—and likelihood of cycling (BIXI and non-BIXI) in Montreal over the first 2 years of implementation. Methods. Three population-based samples of adults participated in telephone surveys. Data collection occurred at the launch of the program (spring 2009), and at the end of the first (fall 2009) and second (fall 2010) seasons of implementation. Difference in differences models assessed whether greater cycling was observed for those exposed to BIXI compared with those not exposed at each time point. Results. We observed a greater likelihood of cycling for those exposed to the public bicycle share program after the second season of implementation (odds ratio = 2.86; 95% confidence interval = 1.85, 4.42) after we controlled for weather, built environment, and individual variables. Conclusions. The implementation of a public bicycle share program can lead to greater likelihood of cycling among persons living in areas where bicycles are made available. PMID:23327280

  8. Determining the Optimal Layout Design for Public Bicycle System within the Attractive Scope of a Metro Station

    Directory of Open Access Journals (Sweden)

    Jingxu Chen

    2015-01-01

    Full Text Available Public bicycle acts as a seamless feeder mode in combination with the citywide public transit, as well as a competitor for the inner-city short trips. The primary objective of this study is to address the layout planning of public bicycle system within the attracted scope of a metro station. Based on the land use function, population, and bicycle mode share, bicycle rental stations are divided into three types, namely, the metro station, district station, and resident station, and later the quantity of bicycle facilities in each rental station is estimated. Then, the service stations are selected from these bicycle rental stations to provide the service of periodical bicycle redistribution. An improved immune algorithm is proposed to determine the number and locations of service stations and the optimal route options for the implement of redistributing strategy. Finally, a case study of Nanjing Tianyin Road metro station is conducted to illustrate the proposed model and clarify some of its implementation details.

  9. Enantioselective Recognition of Calix [4] arene Derivative Bearing Bicyclic Guanidinium for D/L Amino Acid Zwitterions

    Institute of Scientific and Technical Information of China (English)

    刘芳; 陆国元; 何卫江; 王震生; 朱龙根

    2001-01-01

    The p-tetra-tert-butyl calix[4]arene derivatives ( 3 and 4 )with(S,S) chiral bicyclic guanidinium, as the receptors of amino acid zwitterions, have been synthesized via a O-alkylation reaction of p-tetra-tert-rutyi calix [4] arene with chloromethly chiral bicyclic guanidinium 2 in the presence of anhydrous K2CO3 in acetonitrile.The results obtained from liquid-liquid competitive extraction experiments indicate that the two receptors may selectively recognize L-aromatic amino acids, and that the enantioselective recognizability of the receptor 4 with two chiral bicyclic guanidinium units reachs up to about 90% for L-Phe.

  10. Bicycle transport as an object of ecological marketing and innovations in urban transportations

    Directory of Open Access Journals (Sweden)

    O.S. Teletov

    2016-09-01

    Full Text Available The aim of the article. In the modern world society is faced with problems of growing population, increasing environmental problems, lack of minerals and social-economic globalization when necessity of both individual and humanity survival is becoming extremely important. By next few years 80% of the world’s population will live in the cities. This is the main reason which force us to think about the more effective usage of urban space and transport people in cities. Nowadays ecological pollution and increased costs on transport service highlight the importance of seeking alternative types of transport. The youth of many European countries prefer bikes as main transport. Usage of bicycles in Europe is constantly growing due to European and local urban and mobility policies. Therefore, we may consider an opportunity to promote bicycle transport in Ukraine, that requires complex investigation of this question. The purpose of the article is to define features and the ways of bicycle transport implementation in Ukrainian cities as a priority for youth; it includes the best world practices of bicycle transport implementation into urban space and searching for possible ways to apply the European experience in Ukraine. The results of the analysis. As a part of our research we considered investigating international experience of cycling in Europe as an alternative to the public transport and as an example of ecological marketing. The best methods of usage cycling in the urban space were described and analysed. Moreover, we identified the main problems (and the potential solutions with implementation of cycling infrastructure in urban space based on international and national experience (special signs, traffic lights etc.. In the article different opportunities for realization in city Sumy were proposed. Our focus was on atomized network of bike rental services and we confirmed the effectiveness of such program in this city. The bicycle infrastructure

  11. 双圈图的代数连通度%On the algebraic connectivity of bicyclic graphs

    Institute of Scientific and Technical Information of China (English)

    袁西英; 张丽; 孙玉芹

    2007-01-01

    Bicyclic graphs are connected graphs in which the number of edges equals the number of vertices plus one.The aothors study the algebraic connectivity α(G)of a bicyclic graph G on n vertices and prove that α(G)≤1 for all bicyclic graphs G on n(n≥10)vertices.Funhermore they determine all the bicyclic graphs G on n(,n≥10)vertices such that α(G)=1.%边数等于点数加1的连通图称为双圈图.研究双圈图G的代数连通度,记作α(G),证明了结论:对所有的n(n≥10)阶双圈图G都有α(G)≤1成立,并且确定了满足α(G)=1的所有,n(n≥10)阶双圈图.

  12. "Bicycles May Use Full Lane" Signage Communicates U.S. Roadway Rules and Increases Perception of Safety.

    Science.gov (United States)

    Hess, George; Peterson, M Nils

    2015-01-01

    Many global challenges, including obesity, health care costs, and climate change, could be addressed in part by increasing the use of bicycles for transportation. Concern about the safety of bicycling on roadways is frequently cited as a deterrent to increasing bicycle use in the USA. The use of effective signage along roadways might help alleviate these concerns by increasing knowledge about the rights and duties of bicyclists and motorists, ideally reducing crashes. We administered a web-based survey, using Twitter for recruitment, to examine how well three US traffic control devices communicated the message that bicyclists are permitted in the center of the travel lane and do not have to "get out of the way" to allow motorists to pass without changing lanes: "Bicycles May Use Full Lane" and "Share the Road" signage, and Shared Lane Markings on the pavement. Each was compared to an unsigned roadway. We also asked respondents whether it was safe for a bicyclist to occupy the center of the travel lane. "Bicycles May Use Full Lane" signage was the most consistently comprehended device for communicating the message that bicyclists may occupy the travel lane and also increased perceptions of safety. "Share the Road" signage did not increase comprehension or perceptions of safety. Shared Lane Markings fell somewhere between. "Bicycles May Use Full Lane" signage showed notable increases in comprehension among novice bicyclists and private motor vehicle commuters, critical target audiences for efforts to promote bicycling in the USA. Although limited in scope, our survey results are indicative and suggest that Departments of Transportation consider replacing "Share the Road" with "Bicycles May Use Full Lane" signage, possibly combined with Shared Lane Markings, if the intent is to increase awareness of roadway rights and responsibilities. Further evaluation through virtual reality simulations and on-road experiments is merited.

  13. "Bicycles May Use Full Lane" Signage Communicates U.S. Roadway Rules and Increases Perception of Safety.

    Directory of Open Access Journals (Sweden)

    George Hess

    Full Text Available Many global challenges, including obesity, health care costs, and climate change, could be addressed in part by increasing the use of bicycles for transportation. Concern about the safety of bicycling on roadways is frequently cited as a deterrent to increasing bicycle use in the USA. The use of effective signage along roadways might help alleviate these concerns by increasing knowledge about the rights and duties of bicyclists and motorists, ideally reducing crashes. We administered a web-based survey, using Twitter for recruitment, to examine how well three US traffic control devices communicated the message that bicyclists are permitted in the center of the travel lane and do not have to "get out of the way" to allow motorists to pass without changing lanes: "Bicycles May Use Full Lane" and "Share the Road" signage, and Shared Lane Markings on the pavement. Each was compared to an unsigned roadway. We also asked respondents whether it was safe for a bicyclist to occupy the center of the travel lane. "Bicycles May Use Full Lane" signage was the most consistently comprehended device for communicating the message that bicyclists may occupy the travel lane and also increased perceptions of safety. "Share the Road" signage did not increase comprehension or perceptions of safety. Shared Lane Markings fell somewhere between. "Bicycles May Use Full Lane" signage showed notable increases in comprehension among novice bicyclists and private motor vehicle commuters, critical target audiences for efforts to promote bicycling in the USA. Although limited in scope, our survey results are indicative and suggest that Departments of Transportation consider replacing "Share the Road" with "Bicycles May Use Full Lane" signage, possibly combined with Shared Lane Markings, if the intent is to increase awareness of roadway rights and responsibilities. Further evaluation through virtual reality simulations and on-road experiments is merited.

  14. Perceiving and Acting on Complex Affordances: How Children and Adults Bicycle Across Two Lanes of Opposing Traffic

    OpenAIRE

    Grechkin, Timofey Y.; Chihak, Benjamin J.; Cremer, James F.; Kearney, Joseph K.; Plumert, Jodie M.

    2012-01-01

    This investigation examined how children and adults negotiate a challenging perceptual-motor problem with significant real-world implications – bicycling across two lanes of opposing traffic. Twelve- and 14-year-olds and adults rode a bicycling simulator through an immersive virtual environment. Participants crossed intersections with continuous cross traffic coming from opposing directions. Opportunities for crossing were divided into aligned (far gap opens with or before near gap) and rolli...

  15. The risk of pediatric bicycle handlebar injury compared with non-handlebar injury: a retrospective multicenter study in Osaka, Japan

    OpenAIRE

    Hirose, Tomoya; Ogura, Hiroshi; Kiguchi, Takeyuki; Mizushima, Yasuaki; Kimbara, Futoshi; Shimazaki, Junya; Shiono, Shigeru; Yamamura, Hitoshi; Wakai, Akinori; Takegawa, Ryosuke; Matsumoto, Hisatake; Ohnishi, Mitsuo; Shimazu, Takeshi

    2015-01-01

    Background Bicycle accidents are one of the major causes of unintentional traumatic injury in childhood. The purpose of this study was to examine characteristics and risks of handlebar injury in childhood. Methods We conducted a more than 5-year retrospective survey of patients under 15 years of age with bicycle-related injuries admitted to eight urban tertiary emergency centers in Osaka, Japan. Patients were divided into the direct-impact handlebar injury (HI) group and the non-handlebar inj...

  16. The Bicycle – Future’s Solution for an Eco-friendly Urban Transport

    Directory of Open Access Journals (Sweden)

    Cristina Ciovică

    2012-05-01

    Full Text Available Even though more and more cities across the globe impose restrictive measures regarding theuse of cars and offer instead incentives in order to choose alternative means of transport, they do not slowdown their economic growth, but on the contrary they prove their skills towards providing citizens a betterlife. Under these circumstances, the bicycle appears as a viable solution for most of us, and the publicprograms that support its use have started to develop globally, at European level, and in Romania as well.The current paper wishes to point out the stimulating perspectives brought by the slight increase in thenumber of bicycles sold in our country in recent years towards the future of urban transport.

  17. Study of Drive Mechanisms of Bicycle, Tricycle or Like Vehicles to Optimize Operating Performance - A Review

    Directory of Open Access Journals (Sweden)

    Rahul U. Urunkar

    2014-01-01

    Full Text Available A cycle or cycle rickshaw is a small-scale local means of transport. Cycle rickshaws are human-powered, a type of tricycle designed to carry passengers in addition to the driver. Tricycles are used primarily for commercial transportation. Various locally made configurations of bicycle or tricycle are available. The present form of cycle has many shortcomings. One of the major problems faced by available bicycle or tricycle is its less efficiency or mechanical advantage. This paper reviews patent (which are now open for public access and experimental work brought by researchers on drive mechanism of cycle in order to optimize its operating performance. An individual idea or any possible combination of different ideas can be used for optimizing performance of driving mechanism for cycle.

  18. The effect of cannabis on regular cannabis consumers' ability to ride a bicycle.

    Science.gov (United States)

    Hartung, Benno; Schwender, Holger; Roth, Eckhard H; Hellen, Florence; Mindiashvili, Nona; Rickert, Annette; Ritz-Timme, Stefanie; Grieser, Almut; Monticelli, Fabio; Daldrup, Thomas

    2016-05-01

    To assess the effects of cannabis on the ability required to ride a bicycle, repetitive practical cycling tests and medical examinations were carried out before and after inhalative consumption of cannabis. A maximum of three joints with body weight-adapted THC content (300 μg THC per kg body weight) could be consumed by each test subject. Fourteen regular cannabis-consuming test subjects were studied (12 males, 2 females). In summary, only a few driving faults were observed even under the influence of very high THC concentrations. A defined THC concentration that leads to an inability to ride a bicycle cannot be presented. The test subjects showed only slight distinctive features that can be documented using a medical test routinely run for persons under suspicion of driving under the influence of alcohol or drugs. PMID:26739323

  19. Optimal design parameters of the bicycle-rider system for maximal muscle power output.

    Science.gov (United States)

    Yoshihuku, Y; Herzog, W

    1990-01-01

    The purpose of this study was to find the optimal values of design parameters for a bicycle-rider system (crank length, pelvic inclination, seat height, and rate of crank rotation) which maximize the power output from muscles of the human lower limb during bicycling. The human lower limb was modelled as a planar system of five rigid bodies connected by four smooth pin joints and driven by seven functional muscle groups. The muscles were assumed to behave according to an adapted form of Hill's equation. The dependence of the average power on the design parameters was examined. The instantaneous power of each muscle group was studied and simultaneous activity of two seemingly antagonistic muscle groups was analyzed. Average peak power for one full pedal revolution was found to be around 1100 W. The upper body position corresponding to this peak power output was slightly reclined, and the pedalling rate was 155 rpm for a nominal crank length of 170 mm.

  20. Is the three-foot bicycle passing law working in Baltimore, Maryland?

    Science.gov (United States)

    Love, David C; Breaud, Autumn; Burns, Sean; Margulies, Jared; Romano, Max; Lawrence, Robert

    2012-09-01

    Maryland (MD) recently became one of fourteen states in the United States to enact a traffic law requiring motor vehicles to pass bicyclists at a distance of greater than three feet. To our knowledge, motorist compliance with the law has never been assessed. This study measured the distance between overtaking motor vehicles and cyclists [e.g. vehicle passing distance (VPD)], to develop baseline metrics for tracking implementation of the three-foot passing law in Baltimore, MD and to assess risk factors for dangerous passes. During September and October 2011, cyclists (n=5) measured VPD using a previously published video technique (Parkin and Meyers, 2010). Cyclists logged a total of 10.8h of video footage and 586 vehicle passes on 34 bicycle commuting trips. The average trip lasted 19.5±4.9 min and cyclists were passed on average 17.2±11.8 times per trip. VPDs of three feet or less were common when cycling in standard lanes (17%; 78 of 451 passes) and lanes with a shared lane marking (e.g. sharrows) (23%; 11 of 47 passes). No passes of three feet or less occurred in bicycle lanes (0 of 88 passes). A multiple linear regression model was created, which explained 26% of the variability in VPD. Significant model variables were lane width, bicycle infrastructure, cyclist identity, and street identity. Interventions, such as driver education, signage, enforcement, and bicycle infrastructure changes are needed to influence driving behavior in Baltimore to increase motorist compliance with the three-foot law. PMID:22664711

  1. Automatic control of cycling effort using electric bicycles and mobile devices

    OpenAIRE

    Jose A. Afonso; Rodrigues, Filipe J.; Delfim Pedrosa; Joao L. Afonso

    2015-01-01

    This paper describes the development and evaluation of a novel effort control system for cycling, which contributes to promote the users’ mobility and physical health. This system provides automatic control of the motor assistance level of an electric bicycle in order to ensure that the cyclist’s effort remains inside the desired target zone, regardless of changes in other variables which normally affect the effort, such as the slope of the road. The system presented in this paper controls th...

  2. A Universal Design Method for Reflecting Physical Characteristics Variability: Case Study of a Bicycle Frame.

    Science.gov (United States)

    Shimada, Masato; Suzuki, Wataru; Yamada, Shuho; Inoue, Masato

    2016-01-01

    To achieve a Universal Design, designers must consider diverse users' physical and functional requirements for their products. However, satisfying these requirements and obtaining the information which is necessary for designing a universal product is very difficult. Therefore, we propose a new design method based on the concept of set-based design to solve these issues. This paper discusses the suitability of proposed design method by applying bicycle frame design problem. PMID:27534334

  3. The Regional Response to Federal Fundingfor Bicycle and Pedestrian Projects: Executive Summary

    OpenAIRE

    McCann, Barbara; McRee, Lanier; Handy, Susan L; Meharg, Emily; Bailey, Linda; Ewing, Reid; Ernst, Michelle; Wright, Kate

    2009-01-01

    Since its initiation in the early 20th century, the federal transportation funding program has focused on highway construction for automobile travel. In the last few decades, public transportation has received 20% of federal resources, a significant share, but non-motorized modes such as bicycling and walking have historically received very limited funding. Over the past three decades, however, views of non-motorized modes and the federal interest in promoting them have changed dramatically. ...

  4. A simple, enaminone-based approach to some bicyclic pyridazinium tetrafluoroborates

    OpenAIRE

    František Josefík; Markéta Svobodová; Valerio Bertolasi; Petr Šimůnek

    2013-01-01

    Easily obtainable cyclic enaminones (piperidin-2-ylidenealkanones) can be transformed into substituted bicyclic pyridazinium tetrafluoroborates upon treatment with corresponding diazonium salts. The transformation can be performed either in a one-pot way or in a two-step process with the isolation of single azo-coupled enaminone as the intermediate. The former method is superior. Under the optimized conditions, a number of pyridazinium salts substituted with both electron-donating and electro...

  5. 'Cycle thieves, we are watching you': impact of a simple signage intervention against bicycle theft.

    Directory of Open Access Journals (Sweden)

    Daniel Nettle

    Full Text Available BACKGROUND: Bicycle theft is a serious problem in many countries, and there is a lack of evidence concerning effective prevention strategies. Displaying images of 'watching eyes' has been shown to make people behave in more socially desirable ways in a number of settings, but it is not yet clear if this effect can be exploited for purposes of crime prevention. We report the results of a simple intervention on a university campus where signs featuring watching eyes and a related verbal message were displayed above bicycle racks. METHODOLOGY AND PRINCIPAL FINDINGS: We installed durable signs at three locations which had experienced high levels of bicycle theft, and used the rest of the university campus as a control location. Reported thefts were monitored for 12 months before and after the intervention. Bicycle thefts decreased by 62% at the experimental locations, but increased by 65% in the control locations, suggesting that the signs were effective, but displaced offending to locations with no signs. The Odds Ratio for the effect of the intervention was 4.28 (95% confidence interval 2.04-8.98, a large effect compared to other place-based crime prevention interventions. CONCLUSIONS AND SIGNIFICANCE: The effectiveness of this extremely cheap and simple intervention suggests that there can be considerable crime-reduction benefits to engaging the psychology of surveillance, even in the absence of surveillance itself. Simple interventions for high-crime locations based on this principle should be considered as an adjunct to other measures, although a possible negative consequence is displacement of offending.

  6. A sketch planning methodology for determining interventions for bicycle and pedestrian crashes: an ecological approach

    OpenAIRE

    Thakuriah, P.; Cottrill, C.; Thomas, N; Vaughn, S.

    2010-01-01

    Bicycle and pedestrian safety planning have recently been gaining increased attention. With this focus, however, comes increased responsibilities for planning agencies and organizations tasked with evaluating and selecting safety interventions, a potentially arduous task given limited staff and resources. This study presents a sketch planning framework based on ecological factors that attempts to provide an efficient and effective method of selecting appropriate intervention measures. A Chica...

  7. Health effects of the London bicycle sharing system: health impact modelling study

    OpenAIRE

    Woodcock, James; Tainio, Marko; Cheshire, James; O’Brien, Oliver; Goodman, Anna

    2014-01-01

    Objective To model the impacts of the bicycle sharing system in London on the health of its users. Design Health impact modelling and evaluation, using a stochastic simulation model. Setting Central and inner London, England. Data sources Total population operational registration and usage data for the London cycle hire scheme (collected April 2011-March 2012), surveys of cycle hire users (collected 2011), and London data on travel, physical activity, road traffic collisions, and particulate ...

  8. Synthesis and Structure of A Novel Caged Bicyclic Phosphate Flame Retardant

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A novel caged bicyclic phosphate flame retardant tri(1-oxo-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane-methyl) phosphate (Trimer) was synthesized from 1-oxo-4-hydroxymethyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane (PEPA) and phosphorus oxychloride in this paper.Its structure was characterized by elemental analysis, FTIR, 1H NMR, 31P NMR and X-ray diffraction analysis.

  9. ω-Extension of Bicyclic Semigroup%双循环半群的ω扩张

    Institute of Scientific and Technical Information of China (English)

    朱雯; 詹亮

    2009-01-01

    In this paper,we discussed ω-extension of bicyclic semigroups.Two types of this extension are proposed.In §2 we discussed strong semilattice extension and the structure of the extension is well presented.In §3 we discussed another order extension.We proved that congruence lattice of this extension semigroups is union set of two sublattice.One is the group congruence semilattice,the other is the pure idempotent congruence semilattice.

  10. Pedaling into high gear for bicycle policy in Canada : lessons from bike summit 2008 in Toronto

    International Nuclear Information System (INIS)

    The 2008 bike summit provided a forum for the discussion of international and Canadian best practices related to bicycles and bicycling policy. The aim of the summit was to assist communities across Canada to improve conditions for cycling in the urban environment and help to generate a cultural shift towards greater acceptance of cycling on roads. This paper discussed lessons learned during the summit and outlined new methods of improving cycling in communities. The City of London has recently increased the amount of cyclists using its roads by 200 per cent. Cycling infrastructure is more affordable than constructing major public transit or road infrastructure. Savings in healthcare costs will be accrued over time as a result of the healthier lifestyles promoted by regular cycling activity. Bicycle trips can help to alleviate over-demand on heavy transit routes. Encouraging commuters to cycle will also reduce the amounts of greenhouse gases (GHGs) emitted in urban areas. Lane width reductions will help to reduce speeds as drivers are forced to pay more attention when driving. Public bike sharing programs and bike stations are now being used in many North American cities. It was concluded that strong advocacy is needed to ensure the growth and acceptance of cycling in urban centres. 23 figs

  11. 车锁式打气筒设计%Design of Bicycle Lock Type Pump

    Institute of Scientific and Technical Information of China (English)

    王超; 司慧

    2012-01-01

    The design combines a bicycle lock with a pump, realizing a uniform structure of the two. The application of a dual-pump structure makes the pumping process more efficient. In order to facilitate bicycle riders' relaxation, the air pump can also serve as a stool. Compared with carrying a single air pump or a single bicycle lock, this kind of air pump features lost air pumping cost, easy use, low space requirements, convenience to carry steady and reliable operation.%本设计将自行车车锁与打气筒巧妙地结合在一起,实现了二者结构形式的统一。应用双注气杆式打气结构,使打气效率优于现有的便携式打气筒,为了方便骑行者能够就地休息又附加了凳子的功能。与单独携带气筒、单独使用车锁相比,合二为一的车锁式打气筒成本低,使用、携带方便,节省空间,工作过程稳定、可靠。

  12. Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.

    Directory of Open Access Journals (Sweden)

    Suresh B Lakshminarayana

    Full Text Available PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during which the free drug concentrations in plasma are above the MIC (fT>MIC. In this study, a panel of closely related potent bicyclic 4-nitroimidazoles was profiled in both in vivo PK and efficacy studies. In an established murine TB model, the efficacy of diverse nitroimidazole analogs ranged between 0.5 and 2.3 log CFU reduction compared to untreated controls. Further, a retrospective analysis was performed for a set of seven nitroimidazole analogs to identify the PK parameters that correlate with in vivo efficacy. Our findings show that the in vivo efficacy of bicyclic 4-nitroimidazoles correlated better with lung PK than with plasma PK. Further, nitroimidazole analogs with moderate-to-high volume of distribution and Lung to plasma ratios of >2 showed good efficacy. Among all the PK-PD indices, total lung T>MIC correlated the best with in vivo efficacy (rs = 0.88 followed by lung Cmax/MIC and AUC/MIC. Thus, lung drug distribution studies could potentially be exploited to guide the selection of compounds for efficacy studies, thereby accelerating the drug discovery efforts in finding new nitroimidazole analogs.

  13. Influence of roadway geometric elements on driver behavior when overtaking bicycles on rural roads

    Directory of Open Access Journals (Sweden)

    Jeremy R. Chapman

    2014-02-01

    Full Text Available The objective of this research was to determine what influence geometric design elements of roadway may have on driver behavior during the overtaking maneuver. This was part of a larger research effort to eliminate crashes (and the resulting fatalities and injuries between bicycles and motorized vehicles. The data collection process produced 1151 observations with approximately 40 different independent variables for each data point through direct observation, sensor logging, or derivation from other independent variables. Prior research by the authors developed a means to collect real-time field data through the use of a bicycle-mounted data collection system. The collected data was then used to model lateral clearance distance between vehicles and bicycles. The developed model confirmed field observations that the lateral clearance distance provided by drivers changes with vehicle speed and oncoming vehicle presence. These observations were presented by the authors previously. The model shows that driver behavior can be adjusted by the inclusion, or exclusion, of geometric elements. Evaluating roadways (or roadway designs based on this model will enable stakeholders to identify those roadway segments where a paved shoulder would prove an effective safety countermeasure. This research will also enable roadway designers to better identify during the design phase those roadway segments that should be constructed with a paved shoulder.

  14. Boris Loutzky – Creator of the world's first motorized bicycle classic layout with a combustion engine

    Directory of Open Access Journals (Sweden)

    Alexander Firsov

    2012-12-01

    Full Text Available The article is dedicated to creation of the first motor vehicles with internal combustion engines. The purpose of article is to establish the name of the designer who was the first to create the world's motorized bicycle classic layout with a combustion engine. This article describes the construction of the first motorized vehicles Gottlieb Daimler, Edward Butler, Felix Millet, Giuseppe Murniotti, Edward Pennington, Alois Wolfmüller and Hans Geisenhof. based on the analysis of structures of motor vehicles. It’s stated that none of the vehicles can be called a «prototype» of modern mopeds and motorcycles. Based on the research it was found that in Germany Russian engineer B. Loutzky was engaged in creation of motorized vehicles with internal combustion engines even before Hildebrand and Pennington. These motorized vehicles were exhibited in Palermo, Erfurt, Vienna, Prague, Lamberg, Stuttgart and other cities in Europe, and were acknowledged and rewarded with gold medals. The paper describes the design of the first motorized bicycle with a classic layout by B. Loutzky and design of the unique internal combustion engines, which B. Loutzky used in his first vehicles. Overall, based on the analysis of patents for inventions, literary and archival sources, the priority of the Russian engineer B. Loutzky in creation of the motorized bicycle classic layout with a combustion engine is established.

  15. Built environment effects on cyclist injury severity in automobile-involved bicycle crashes.

    Science.gov (United States)

    Chen, Peng; Shen, Qing

    2016-01-01

    This analysis uses a generalized ordered logit model and a generalized additive model to estimate the effects of built environment factors on cyclist injury severity in automobile-involved bicycle crashes, as well as to accommodate possible spatial dependence among crash locations. The sample is drawn from the Seattle Department of Transportation bicycle collision profiles. This study classifies the cyclist injury types as property damage only, possible injury, evident injury, and severe injury or fatality. Our modeling outcomes show that: (1) injury severity is negatively associated with employment density; (2) severe injury or fatality is negatively associated with land use mixture; (3) lower likelihood of injuries is observed for bicyclists wearing reflective clothing; (4) improving street lighting can decrease the likelihood of cyclist injuries; (5) posted speed limit is positively associated with the probability of evident injury and severe injury or fatality; (6) older cyclists appear to be more vulnerable to severe injury or fatality; and (7) cyclists are more likely to be severely injured when large vehicles are involved in crashes. One implication drawn from this study is that cities should increase land use mixture and development density, optimally lower posted speed limits on streets with both bikes and motor vehicles, and improve street lighting to promote bicycle safety. In addition, cyclists should be encouraged to wear reflective clothing. PMID:26609666

  16. A Geo-Aware and VRP-Based Public Bicycle Redistribution System

    Directory of Open Access Journals (Sweden)

    J. H. Lin

    2012-01-01

    Full Text Available Public Bicycle System (PBS has been developed for short-distance transportation as a part of the mass transportation system. The supply and demand of bikes in PBS is usually unbalanced at different stations and needs to be continuously and widely monitored and redistributed. The bicycle redistribution is a part of the vehicle routing problem (VRP. We can apply solutions to the VRP to redistribute bicycle efficiently. However, most solutions to the VRP use the Euclidean distance as the condition factor, which does not take road conditions, traffic regulations, and geographical factors into account, resulting in unnecessary waste of delivery time and human resources. In this work, we propose an actual path distance optimization method for the VRP to adapt the several additional constraints of road problems. We also implement a system that integrates real-time station information, Web GIS, the urban road network, and heuristics algorithms for PBS. The system includes a simulator inside that can assist PBS managers to do the route planning efficiently and find the best scheduling strategy to achieve hotspot analysis and the adjustment of station deployment strategies to reduce PBS operation cost.

  17. Factors of the safety in bicycle traffic in the City of Zagreb and its surrounding

    Directory of Open Access Journals (Sweden)

    Sindik Joško

    2014-01-01

    Full Text Available The aim of this study was to determine the differences in underlying factors of Zagreb cycling, compared to the "types of cyclists" (driving style, i.e. different ways of using bicycles as a means of transport. The study included over 3,000 frequent participants in urban traffic cycling, sample of members of the association Cyclist Union (N = 1259 and snowball sample of "typical" of cyclists, i.e. people who are using the bike, but are not the members of the Cyclist Union (N = 1831, using the conveniently assembled questionnaire. Study participants who bike used in various applications prefer the safest driving style (only on sidewalks and bike paths / lines. Barriers of the weather conditions are ubiquitous in the safest driving style. Daily, weekly and yearly riding a bicycle are more often found in those who prefer the safest driving style. Cyclists who drive with medium secure style (roads with less traffic and lower speeds, more often ride a bike, as compared with those who prefer the safest driving style. Having a better bike line / track and other infrastructure is the most often considered at those with the highest risk driving style. The results provide the guidance for local authorities and for the cyclists to improve the conditions for a safer and more often by bicycle circulation in the City of Zagreb and its surroundings.

  18. The effect of alcohol hangover on the ability to ride a bicycle.

    Science.gov (United States)

    Hartung, Benno; Schwender, Holger; Mindiashvili, Nona; Ritz-Timme, Stefanie; Malczyk, Axel; Daldrup, Thomas

    2015-07-01

    To investigate the effects of alcohol on the ability to ride a bicycle, practical cycling tests were carried out at different blood alcohol concentrations (BAC). For this purpose, various alcoholic beverages could be consumed from around 2 p.m. until 11 p.m. Afterwards, the test persons spent the night on the trial site and were provided with dormitory sleeping accommodation. On the following morning, beginning at around 8 a.m., a final cycling test was performed. The performances of those test persons who had returned to state of soberness and of those with residual blood alcohol levels were compared to the performances on the day before. The practical ability to ride a bicycle was significantly reduced in the postalcoholic state compared to the rides of the day before. The relative cycling performance in the postalcoholic state was comparable to the rides under the influence of BAC of around 0.30 g/kg. There were no remarkable differences between the groups with and without residual blood alcohol levels regarding the rides on the next morning. Therefore, it can be assumed that the direct influence of residual blood alcohol levels plays a minor role for the ability to ride a bicycle in the postalcoholic state. Instead, the side effects of the high amounts of alcohol that were consumed the night before are crucial. PMID:25940454

  19. Study of electrode slice forming of bicycle dynamo hub power connector

    Science.gov (United States)

    Chen, Dyi-Cheng; Jao, Chih-Hsuan

    2013-12-01

    Taiwan's bicycle industry has been an international reputation as bicycle kingdom, but the problem in the world makes global warming green energy rise, the development of electrode slice of hub dynamo and power output connector to bring new hope to bike industry. In this study connector power output to gather public opinion related to patent, basis of collected documents as basis for design, structural components in least drawn to power output with simple connector. Power output of this study objectives connector hope at least cost, structure strongest, highest efficiency in output performance characteristics such as use of computer-aided drawing software Solid works to establish power output connector parts of 3D model, the overall portfolio should be considered part types including assembly ideas, weather resistance, water resistance, corrosion resistance to vibration and power flow stability. Moreover the 3D model import computer-aided finite element analysis software simulation of expected the power output of the connector parts manufacturing process. A series of simulation analyses, in which the variables relied on first stage and second stage forming, were run to examine the effective stress, effective strain, press speed, and die radial load distribution when forming electrode slice of bicycle dynamo hub.

  20. Built environment effects on cyclist injury severity in automobile-involved bicycle crashes.

    Science.gov (United States)

    Chen, Peng; Shen, Qing

    2016-01-01

    This analysis uses a generalized ordered logit model and a generalized additive model to estimate the effects of built environment factors on cyclist injury severity in automobile-involved bicycle crashes, as well as to accommodate possible spatial dependence among crash locations. The sample is drawn from the Seattle Department of Transportation bicycle collision profiles. This study classifies the cyclist injury types as property damage only, possible injury, evident injury, and severe injury or fatality. Our modeling outcomes show that: (1) injury severity is negatively associated with employment density; (2) severe injury or fatality is negatively associated with land use mixture; (3) lower likelihood of injuries is observed for bicyclists wearing reflective clothing; (4) improving street lighting can decrease the likelihood of cyclist injuries; (5) posted speed limit is positively associated with the probability of evident injury and severe injury or fatality; (6) older cyclists appear to be more vulnerable to severe injury or fatality; and (7) cyclists are more likely to be severely injured when large vehicles are involved in crashes. One implication drawn from this study is that cities should increase land use mixture and development density, optimally lower posted speed limits on streets with both bikes and motor vehicles, and improve street lighting to promote bicycle safety. In addition, cyclists should be encouraged to wear reflective clothing.

  1. A solid solution to a conjecture on the maximal energy of bipartite bicyclic graphs

    CERN Document Server

    Huo, Bofeng; Li, Xueliang; Shi, Yongtang

    2011-01-01

    The energy of a simple graph $G$, denoted by $E(G)$, is defined as the sum of the absolute values of all eigenvalues of its adjacency matrix. Let $C_n$ denote the cycle of order $n$ and $P^{6,6}_n$ the graph obtained from joining two cycles $C_6$ by a path $P_{n-12}$ with its two leaves. Let $\\mathscr{B}_n$ denote the class of all bipartite bicyclic graphs but not the graph $R_{a,b}$, which is obtained from joining two cycles $C_a$ and $C_b$ ($a, b\\geq 10$ and $a \\equiv b\\equiv 2\\, (\\,\\textmd{mod}\\, 4)$) by an edge. In [I. Gutman, D. Vidovi\\'{c}, Quest for molecular graphs with maximal energy: a computer experiment, {\\it J. Chem. Inf. Sci.} {\\bf41}(2001), 1002--1005], Gutman and Vidovi\\'{c} conjectured that the bicyclic graph with maximal energy is $P^{6,6}_n$, for $n=14$ and $n\\geq 16$. In [X. Li, J. Zhang, On bicyclic graphs with maximal energy, {\\it Linear Algebra Appl.} {\\bf427}(2007), 87--98], Li and Zhang showed that the conjecture is true for graphs in the class $\\mathscr{B}_n$. However, they could not...

  2. The impact of transportation infrastructure on bicycling injuries and crashes: a review of the literature

    Directory of Open Access Journals (Sweden)

    Cripton Peter A

    2009-10-01

    Full Text Available Abstract Background Bicycling has the potential to improve fitness, diminish obesity, and reduce noise, air pollution, and greenhouse gases associated with travel. However, bicyclists incur a higher risk of injuries requiring hospitalization than motor vehicle occupants. Therefore, understanding ways of making bicycling safer and increasing rates of bicycling are important to improving population health. There is a growing body of research examining transportation infrastructure and the risk of injury to bicyclists. Methods We reviewed studies of the impact of transportation infrastructure on bicyclist safety. The results were tabulated within two categories of infrastructure, namely that at intersections (e.g. roundabouts, traffic lights or between intersections on "straightaways" (e.g. bike lanes or paths. To assess safety, studies examining the following outcomes were included: injuries; injury severity; and crashes (collisions and/or falls. Results The literature to date on transportation infrastructure and cyclist safety is limited by the incomplete range of facilities studied and difficulties in controlling for exposure to risk. However, evidence from the 23 papers reviewed (eight that examined intersections and 15 that examined straightaways suggests that infrastructure influences injury and crash risk. Intersection studies focused mainly on roundabouts. They found that multi-lane roundabouts can significantly increase risk to bicyclists unless a separated cycle track is included in the design. Studies of straightaways grouped facilities into few categories, such that facilities with potentially different risks may have been classified within a single category. Results to date suggest that sidewalks and multi-use trails pose the highest risk, major roads are more hazardous than minor roads, and the presence of bicycle facilities (e.g. on-road bike routes, on-road marked bike lanes, and off-road bike paths was associated with the lowest

  3. A Comparison of Static and Dynamic Measures of Lower Limb Joint Angles in Cycling: Application to Bicycle Fitting

    Directory of Open Access Journals (Sweden)

    Bini Rodrigo Rico

    2016-03-01

    Full Text Available Purpose. Configuration of bicycle components to the cyclist (bicycle fitting commonly uses static poses of the cyclist on the bicycle at the 6 o’clock crank position to represent dynamic cycling positions. However, the validity of this approach and the potential use of the different crank position (e.g. 3 o’clock have not been fully explored. Therefore, this study compared lower limb joint angles of cyclists in static poses (3 and 6 o’clock compared to dynamic cycling. Methods. Using a digital camera, right sagittal plane images were taken of thirty cyclists seated on their own bicycles mounted on a stationary trainer with the crank at 3 o’clock and 6 o’clock positions. Video was then recorded during pedalling at a self-selected gear ratio and pedalling cadence. Sagittal plane hip, knee and ankle angles were digitised. Results. Differences between static and dynamic angles were large at the 6 o’clock crank position with greater mean hip angle (4.9 ± 3°, smaller knee angle (8.2 ± 5° and smaller ankle angle (8.2 ± 5.3° for static angles. Differences between static and dynamic angles (< 1.4° were trivial to small for the 3 o’clock crank position. Conclusions. To perform bicycle fitting, joint angles should be measured dynamically or with the cyclist in a static pose at the 3 o’clock crank position.

  4. Angular Impact Mitigation System for Bicycle Helmets to Reduce Head Acceleration and Risk of Traumatic Brain Injury

    Science.gov (United States)

    Hansen, Kirk; Dau, Nathan; Feist, Florian; Deck, Caroline; Willinger, Rémy; Madey, Steven M.; Bottlang, Michael

    2013-01-01

    Angular acceleration of the head is a known cause of traumatic brain injury (TBI), but contemporary bicycle helmets lack dedicated mechanisms to mitigate angular acceleration. A novel Angular Impact Mitigation (AIM) system for bicycle helmets has been developed that employs an elastically suspended aluminum honeycomb liner to absorb linear acceleration in normal impacts as well as angular acceleration in oblique impacts. This study tested bicycle helmets with and without AIM technology to comparatively assess impact mitigation. Normal impact tests were performed to measure linear head acceleration. Oblique impact tests were performed to measure angular head acceleration and neck loading. Furthermore, acceleration histories of oblique impacts were analyzed in a computational head model to predict the resulting risk of TBI in the form of concussion and diffuse axonal injury (DAI). Compared to standard helmets, AIM helmets resulted in a 14% reduction in peak linear acceleration (p < 0.001), a 34% reduction in peak angular acceleration (p < 0.001), and a 22% to 32% reduction in neck loading (p < 0.001). Computational results predicted that AIM helmets reduced the risk of concussion and DAI by 27% and 44%, respectively. In conclusion, these results demonstrated that AIM technology could effectively improve impact mitigation compared to a contemporary expanded polystyrene-based bicycle helmet, and may enhance prevention of bicycle-related TBI. Further research is required. PMID:23770518

  5. The effectiveness of helmets in bicycle collisions with motor vehicles: a case-control study.

    Science.gov (United States)

    Bambach, M R; Mitchell, R J; Grzebieta, R H; Olivier, J

    2013-04-01

    There has been an ongoing debate in Australia and internationally regarding the effectiveness of bicycle helmets in preventing head injury. This study aims to examine the effectiveness of bicycle helmets in preventing head injury amongst cyclists in crashes involving motor vehicles, and to assess the impact of 'risky cycling behaviour' among helmeted and unhelmeted cyclists. This analysis involved a retrospective, case-control study using linked police-reported road crash, hospital admission and mortality data in New South Wales (NSW), Australia during 2001-2009. The study population was cyclist casualties who were involved in a collision with a motor vehicle. Cases were those that sustained a head injury and were admitted to hospital. Controls were those admitted to hospital who did not sustain a head injury, or those not admitted to hospital. Standard multiple variable logistic regression modelling was conducted, with multinomial outcomes of injury severity. There were 6745 cyclist collisions with motor vehicles where helmet use was known. Helmet use was associated with reduced risk of head injury in bicycle collisions with motor vehicles of up to 74%, and the more severe the injury considered, the greater the reduction. This was also found to be true for particular head injuries such as skull fractures, intracranial injury and open head wounds. Around one half of children and adolescents less than 19 years were not wearing a helmet, an issue that needs to be addressed in light of the demonstrated effectiveness of helmets. Non-helmeted cyclists were more likely to display risky riding behaviour, however, were less likely to cycle in risky areas; the net result of which was that they were more likely to be involved in more severe crashes. PMID:23377086

  6. Attention and expectation problems in bicycle-car collisions: an in-depth study.

    Science.gov (United States)

    Räsänen, M; Summala, H

    1998-09-01

    One hundred and eighty-eight bicycle-car accidents in four cities were studied by multidisciplinary in-depth analysis. The sample was representative of the national accident statistics. All the accidents were analyzed in detail to reconstruct the actual movements of those involved and to assess detection of the other party. In 37% of collisions, neither driver nor cyclist realized the danger or had time to yield. In the remaining collisions, the driver (27%), the cyclist (24%) or both (12%) did something to avert the accident. Two common mechanisms underlying the accidents were identified. First, allocation of attention such that others were not detected, and second, unjustified expectations about the behavior of others. These mechanisms were found to be closely related to the system of two-way cycle tracks and to the fact that the general priority rule is applied to the crossings of a cycle track and a roadway. The most frequent accident type among collisions between cyclists and cars at bicycle crossings was a driver turning right and a bicycle coming from the driver's right along a cycle track. The result confirmed an earlier finding (Accident Analysis and Prevention 28, 147-153, 1996) that drivers turning right hit cyclists because they looked left for cars during the critical phase. Only 11% of drivers noticed the cyclist before impact. Cyclists' behavior was in marked contrast to that of drivers. In these cases, 68% of cyclists noticed the driver before the accident, and 92% of those who noticed believed the driver would give way as required by law. Cyclists with a driving license and those who cycled daily through the accident site were involved in different accident types to other cyclists. PMID:9678219

  7. Deaths of bicycle riders in Brazil: characteristics and trends during the period of 2000 - 2010

    Directory of Open Access Journals (Sweden)

    Leila Posenato Garcia

    2013-12-01

    Full Text Available INTRODUCTION: In Brazil, bicycle use has been increasing. Accidents involving cyclists are important causes of morbidity and mortality. OBJECTIVE: To describe the mortality of cyclists injured in transport accidents in Brazil, the characteristics of the victims and of the occurrence, and to investigate its trends during the period between 2000 and 2010. METHODS: A descriptive study with data from the Mortality Information System (SIM was conducted in the period of 2000 - 2010. Crude and age-standardized corrected mortality rates were calculated for Brazil, its macro-regions and states. Linear regression was used to study the trends. RESULTS: In the period of 2000 - 2010, 32,422 bicycle-related deaths were identified in Brazil. In 2010, there were, on average, 8.8 bicycle-related deaths per day. Age-standardized mortality rates for the country were 15.3 and 15.9 deaths per million inhabitants in 2000 and 2010, respectively (p = 0.725. During the whole period, the Center-Western region showed the highest rates, though stable, corresponding to 23.4 deaths per million inhabitants in 2010. Men accounted for 85.4% of deaths, with death risk 5 times higher than women. CONCLUSION: In spite of the stable rates for the country, there was an increase trend in the Northern and Northeastern regions, while a decreasing trend was observed in the Southern and Southeastern regions. The risk of death was higher among men, elderly, and people living in large cities and at the Center-Western region.

  8. A wearable ECG-HR detector and its application to automatic assist-mode selection of an electrically assisted bicycle.

    Science.gov (United States)

    Ueno, Akinori; Miyashita, Osamu; Yoshida, Toshiya; Yamamoto, Junichi; Lataire, Philippe

    2011-01-01

    Recently, an electrically assisted bicycle has been widely used in daily life and becomes very popular. The user selects the stepwise assist-mode to determine the assistive torque for pleasurable running. From the viewpoint of improvement of health by exercise, the electrically assisted bicycle can be an exercise machine like a treadmill. The heart rate (HR) is regarded as an indication of exercise load. This paper presents an automatic assist-mode selection system based on the HR of the bicycle user. The HR is obtained from the R-waves measured by the proposed wearable electrocardiograph on the user. The mode-selection system is simply implemented by a personal computer, USB-connected interface, and some electronic switching circuits. The running experiments confirm that the proposed assist-mode selection method has practicability. PMID:22255925

  9. A review on bicycle and motorcycle rider control with a perspective on handling qualities

    Science.gov (United States)

    Kooijman, J. D. G.; Schwab, A. L.

    2013-11-01

    This paper is a review study on handling and control of bicycles and motorcycles, the so-called single-track vehicles. The first part gives a brief overview on the modelling of the dynamics of single-track vehicles and the experimental validation. The second part focusses on a review of modelling and measuring human rider control. The third part deals with the concepts of handling and manoeuvrability and their experimental validation. Parallels are drawn with the literature on aircraft handling and pilot models. The paper concludes with the open ends and promising directions for future work in the field of handling and control of single-track vehicles.

  10. [The electrical stimulation bicycle: a neuroprosthesis for the everyday use of paraplegic patients].

    Science.gov (United States)

    Szecsi, J; Fiegel, M; Krafczyk, S; Straube, A; Quintern, J; Brandt, Th

    2004-06-24

    Until recently, few patients with complete paraplegia could walk or stand with the help of functional electrical stimulation (FES) of the leg muscles regularly at home. In comparison, FES cycling with an adapted tricycle is easy to put into practice because the legs remain connected to the pedals and through the use of a tricycle or stationary bicycle, the balancing problems of the patient recedes into the background. In the first German feasibility studies for paraplegic cycling, eleven completely paraplegic patients have been tested so far. The goal is to make FES cycling a daily activity in the lives of as many patients as possible.

  11. Feasibility study on a perceived fatigue prediction dependent power control for an electrically assisted bicycle.

    Science.gov (United States)

    Kiryu, T; Minagawa, H

    2013-01-01

    Several types of electric motor assists have been developed, as a result, it is important to control muscular fatigue on-site in terms of health promotion and motor rehabilitation. Predicting the perceived fatigue by several biosignal-related variables with the multiple regression model and polynomial approximation, we try to propose a self control design for the electrically assisted bicycle (EAB). We also determine the meaningful muscles during pedaling by muscle synergies in relation to the motion maturity. In field experiments, prediction of ongoing perceived physical fatigue could have the potential of suitable control of EAB.

  12. Enantiospecific Synthesis of All Four Stereoisomers of Novel Bicyclic Arylacetamides as κ—Opioid Agonists

    Institute of Scientific and Technical Information of China (English)

    龙亚秋; 牟奇勇; 仇达萍; 吴瑞琴

    2002-01-01

    Conformationally constrained bicyclic derivatives of the potent and selective κ-opioid receptor agonist 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-Phenyl-2-(1-Pyrrolidinyl)-ethyl]acetamide(3,ICI-199,441)were designed to explore the effect of the conformational restriction and stereochemistry of the pharmacophoric ethylenediamine incorporated into the pyrrolidine on the affinity and κ-selectivity.A facile enantiosipecitfic synthetic route was extablished to afford all four stereoisomers starting from readily available amino acids through mild cyclization and amide formation.

  13. Enantiospecific Synthesis of All Four Stereoisomers of Novel Bicyclic Arylacetamides as κ-Opioid Agonists

    Institute of Scientific and Technical Information of China (English)

    LONG,Ya-Qiu(龙亚秋); MOU,Qi-Yong(牟奇勇); QIU,Da-Ping(仇达萍); WU,Rui-Qin(吴瑞琴)

    2002-01-01

    Conformationally constrained bicyclic derivatives of the potent and selective κ-opioid receptor agonist 2-(3,4-dichlorophenyl)-N-methyl- N- [ (1S ) - 1-phenyl-2- (1-pyrrolidinyl)-ethyl] acetamide (3, ICI-199,441) were designed to explore the effect of the conformational restriction and stereochemistry of the pharmacophoric ethylenediamine incorporated into the pyrrolidine on the affinity and κ-selectivity. A facile enantiospecific synthetic route was established to afford all four stereoisomers starting from readily available amino acids through mild cyclization and amide formation.

  14. Feasibility study on a perceived fatigue prediction dependent power control for an electrically assisted bicycle.

    Science.gov (United States)

    Kiryu, T; Minagawa, H

    2013-01-01

    Several types of electric motor assists have been developed, as a result, it is important to control muscular fatigue on-site in terms of health promotion and motor rehabilitation. Predicting the perceived fatigue by several biosignal-related variables with the multiple regression model and polynomial approximation, we try to propose a self control design for the electrically assisted bicycle (EAB). We also determine the meaningful muscles during pedaling by muscle synergies in relation to the motion maturity. In field experiments, prediction of ongoing perceived physical fatigue could have the potential of suitable control of EAB. PMID:24110131

  15. [The electrical stimulation bicycle: a neuroprosthesis for the everyday use of paraplegic patients].

    Science.gov (United States)

    Szecsi, J; Fiegel, M; Krafczyk, S; Straube, A; Quintern, J; Brandt, Th

    2004-06-24

    Until recently, few patients with complete paraplegia could walk or stand with the help of functional electrical stimulation (FES) of the leg muscles regularly at home. In comparison, FES cycling with an adapted tricycle is easy to put into practice because the legs remain connected to the pedals and through the use of a tricycle or stationary bicycle, the balancing problems of the patient recedes into the background. In the first German feasibility studies for paraplegic cycling, eleven completely paraplegic patients have been tested so far. The goal is to make FES cycling a daily activity in the lives of as many patients as possible. PMID:15529690

  16. Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

    OpenAIRE

    Menachem J. Gunzburg; Ketav Kulkarni; Gabrielle M. Watson; Ambaye, Nigus D.; Del Borgo, Mark P.; Rebecca Brandt; Stephanie C. Pero; Patrick Perlmutter; Wilce, Matthew C. J.; Wilce, Jacqueline A

    2016-01-01

    The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain. This revealed an unexpected binding mode of the peptide, in which the staple forms a...

  17. Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

    DEFF Research Database (Denmark)

    Bolvig, T; Larsson, O M; Pickering, D S;

    1999-01-01

    transporter-1 (GAT-1), GAT-2, -3 or -4. It was found that 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol (THPO) and 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO) displayed some inhibitory activity on GAT-1 and GAT-2, where the compounds exhibited a slightly lower potency on GAT-2 compared to GAT-1...... anticonvulsant activity, lack of proconvulsant activity and the ability of THPO to increase extracellular GABA concentration, indicate that these bicyclic isoxazole GABA analogues and their DPB derivatives may be useful lead structures in future search for new antiepileptic drugs....

  18. Aliphatic and aromatic hydrocarbons in Candiota coal samples: novel series of bicyclic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, A.C.M.L.; Loureiro, M.R.B.; Cardoso, J.N. [Universidade Federal do Rio de Janeiro, Rio de Janeiro (Brazil). Inst. de Quimica

    1999-07-01

    Gas chromatography - mass spectrometry was used to analyse aliphatic and aromatic fractions obtained from nine samples taken from two different seams of five boreholes in the Candiota coalfield (Lower Permian). The occurrence of certain tetracyclic diterpenoids among the aliphatic hydrocarbons, and the tricyclic diterpenoids simonellite and retene in the aromatic hydrocarbon concentrates, suggest an important input from conifers to the sedimentary biomass. This may explain the origin of a novel series of saturated and aromatic bicyclic compounds detected in the extracts which may be structurally related to the same precursor, possibly a conifer resin-derived tricyclic diterpenoid.

  19. Understanding adolescents' intentions to commute by car or bicycle as adults

    DEFF Research Database (Denmark)

    Sigurdardottir, Sigrun Birna; Kaplan, Sigal; Møller, Mette;

    2013-01-01

    This study focuses on the intentions of adolescents to commute by car or bicycle as adults. The behavioral model is based on intrapersonal and interpersonal constructs from the theory of planned behavior extended to include constructs from the institutional, community and policy domains. Data from...... a survey among Danish adolescents is analyzed. It is found that car use intentions are related to positive car passenger experience, general interest in cars, and car ownership norms, and are negatively related to willingness to accept car restrictions and perceived lack of behavioral control. Cycling...

  20. Comparison between treadmill and bicycle ergometer exercise tests in mild-to-moderate hypertensive Nigerians

    Directory of Open Access Journals (Sweden)

    Abiodun OO

    2015-08-01

    Full Text Available Olugbenga O Abiodun, Michael O Balogun, Anthony O Akintomide, Rasaaq A Adebayo, Olufemi E Ajayi, Suraj A Ogunyemi, Valentine N Amadi, Victor O Adeyeye Cardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC, Ile-Ife, Osun state, Nigeria Background: Comparative cardiovascular responses to treadmill and bicycle ergometer (bike exercise tests in hypertensive Nigerians are not known. This study compared cardiovascular responses to the two modes of exercise testing in hypertensives using maximal exercise protocols. Methods: One hundred and ten male subjects with mild-to-moderate hypertension underwent maximal treadmill and bike test one after the other at a single visit in a simple random manner. Paired-sampled t-test was used to compare responses to both exercise tests while chi-squared test was used to compare categorical variables. Results: The maximal heart rate (P<0.001, peak systolic blood pressure (P=0.02, rate pressure product (P<0.001, peak oxygen uptake (P<0.001, and exercise capacity (P<0.001 in metabolic equivalents were significantly higher on the treadmill than on the bike. Conclusion: Higher cardiovascular responses on treadmill in Nigerian male hypertensives in this study, similar to findings in non-hypertensives and non-Nigerians in earlier studies, suggest that treadmill may be of better diagnostic utility in our population. Keywords: maximal exercise, treadmill, bicycle ergometer, hypertension, Nigerians

  1. 双圈图的Laplacian Spread%The Laplacian Spread of Bicyclic Graphs

    Institute of Scientific and Technical Information of China (English)

    刘颖; 王立庆

    2011-01-01

    Laplacian spread的概念在刻画图的整体性质方面非常重要.近年来,Fan等分别刻画了树中具有极大和极小Lap|acian spread的图.另外Bao等确定了在所有单圈图中具有极大Laplacian spread的图.边数减去顶点数目为1的连通图称为双圈图.令召。是所有有几个顶点构成的双圈图集合.对n≥11,本文确定了Bn中所有具有极大Laplacian spread的那些图.%The notion of Laplacian spread is very important in characterizing the global structural property of graphs. Recently, Fan et al. showed that K1,n-1 and Pn are the only trees with the maximal and the minimal Laplacian spread among all trees with n vertices, respectively. Furthermore, Bao etal. determined the graph with the maximal Laplacian spread among all unicyclic graphs. Connected graphs in which the number of edges equals the number of vertices plus one are called bicyclic graphs. Let Bn be the set of all bicyclic graphs with n vertices. In this paper, we continue the work on Laplacian spread of graphs, and determine those graphs with the maximal Laplacian spread in Bn for n≥11.

  2. Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis.

    Science.gov (United States)

    Sontakke, Vyankat A; Lawande, Pravin P; Kate, Anup N; Khan, Ayesha; Joshi, Rakesh; Kumbhar, Anupa A; Shinde, Vaishali S

    2016-04-26

    An efficient route was developed for synthesis of bicyclic benzimidazole nucleosides from readily available d-glucose. The key reactions were Vörbruggen glycosylation and ring closing metathesis (RCM). Primarily, to understand the mode of DNA binding, we performed a molecular docking study and the binding was found to be in the minor groove region. Based on the proposed binding model, UV-visible and fluorescence spectroscopic techniques using calf thymus DNA (CT-DNA) demonstrated a non-intercalative mode of binding. Antiproliferative activity of nucleosides was tested against MCF-7 and MDA-MB-231 breast cancer cell lines and found to be active at low micromolar concentrations. Compounds and displayed significant antiproliferative activity as compared to and with the reference anticancer drug, doxorubicin. Cell cycle analysis showed that nucleoside induced cell cycle arrest at the S-phase. Confocal microscopy has been performed to validate the induction of cellular apoptosis. Based on these findings, such modified bicyclic benzimidazole nucleosides will make a significant contribution to the development of anticancer drugs. PMID:27074628

  3. The Structure of Spatial Networks and Communities in Bicycle Sharing Systems

    Science.gov (United States)

    Zaltz Austwick, Martin; O’Brien, Oliver; Strano, Emanuele; Viana, Matheus

    2013-01-01

    Bicycle sharing systems exist in hundreds of cities around the world, with the aim of providing a form of public transport with the associated health and environmental benefits of cycling without the burden of private ownership and maintenance. Five cities have provided research data on the journeys (start and end time and location) taking place in their bicycle sharing system. In this paper, we employ visualization, descriptive statistics and spatial and network analysis tools to explore system usage in these cities, using techniques to investigate features specific to the unique geographies of each, and uncovering similarities between different systems. Journey displacement analysis demonstrates similar journey distances across the cities sampled, and the (out)strength rank curve for the top 50 stands in each city displays a similar scaling law for each. Community detection in the derived network can identify local pockets of use, and spatial network corrections provide the opportunity for insight above and beyond proximity/popularity correlations predicted by simple spatial interaction models. PMID:24040320

  4. Does Bicycle Riding Impact the Development of Lower Urinary Tract Symptoms and Sexual Dysfunction in Men?

    Science.gov (United States)

    Kim, Dong Gon; Kim, Dae Woong

    2011-01-01

    Purpose This study was designed to determine whether men who engaged in recreational bicycle riding are more likely to be affected by lower urinary tract symptoms (LUTS) and sexual dysfunction than are man who exercised by amateur marathon running with less perineal impact. Materials and Methods A total of 22 healthy male amateur bicyclists and 17 healthy male amateur marathoners were enrolled in the study. We evaluated questionnaires including the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function (IIEF), serum prostate-specific antigen (PSA), uroflowmetric values, postvoid residual (PVR) urine volume, and transrectal ultrasound of the prostate in all subjects. We also compared the prevalence of urination disorders (UD) and erectile dysfunction (ED). Results There were no significant differences between the two groups in age, body mass index, comorbidities, or exercise habits (p>0.05). Mean total and subscale scores of the IPSS and IIEF and the prevalence of UD (8/22 vs. 4/17, p=0.494) and ED (11/22 vs. 10/17, p=0.748) were not significantly different between the two groups. Also, there were no significant differences between the two groups in uroflowmetric parameters such as peak urinary flow rates, voided urine volume, PVR urine volume, prostate volume, or serum PSA level. Conclusions Bicycle riding seems to have no measurable hazardous effect on voiding function or sexual function in men who cycled recreationally. PMID:21687396

  5. The structure of spatial networks and communities in bicycle sharing systems.

    Directory of Open Access Journals (Sweden)

    Martin Zaltz Austwick

    Full Text Available Bicycle sharing systems exist in hundreds of cities around the world, with the aim of providing a form of public transport with the associated health and environmental benefits of cycling without the burden of private ownership and maintenance. Five cities have provided research data on the journeys (start and end time and location taking place in their bicycle sharing system. In this paper, we employ visualization, descriptive statistics and spatial and network analysis tools to explore system usage in these cities, using techniques to investigate features specific to the unique geographies of each, and uncovering similarities between different systems. Journey displacement analysis demonstrates similar journey distances across the cities sampled, and the (outstrength rank curve for the top 50 stands in each city displays a similar scaling law for each. Community detection in the derived network can identify local pockets of use, and spatial network corrections provide the opportunity for insight above and beyond proximity/popularity correlations predicted by simple spatial interaction models.

  6. Injuries Due to Wedging of Bicycle Wheels in On-road Tram Tracks

    Science.gov (United States)

    Deunk, Jaap; Harmsen, Annelieke M. K.; Schonhuth, Casper P.; Bloemers, Frank W.

    2014-01-01

    Background: In cities with trams as public transportation, tram tracks are often on public roads, creating a shared road situation with other road participants like cyclists. Beside the risk of direct collisions, this situation can also lead to bicycle wheels getting wedged in tram tracks, causing cyclists to fall. Objectives: The aim of this study was to gain more insight in the injury pattern of this trauma mechanism and to draw attention to the risks of the infrastructural situation with on-road tram tracks. Patients and Methods: A one-year, prospective, observational cohort study was conducted. All patients admitted after presentation to the emergency department of a level 1 trauma center, who got injured because their bicycle wheels got wedged in tram tracks, were included. Data were collected on patient demographics, type of injury and treatment. Results: Ten patients were included. Six were male. The mean age was 38 years. Six patients required surgery, mostly because of extremity injuries. Mean duration of admission was 4 days. Mean injury severity score was 13. One patient died as a result of the injuries sustained in the accident. Conclusions: Tram tracks on public roads are potentially dangerous and can lead to serious injuries and even mortality amongst cyclist. Operative intervention is frequently needed. PMID:25685751

  7. Long-term use of computerized bicycle ergometry for spinal cord injured subjects.

    Science.gov (United States)

    Sipski, M L; Alexander, C J; Harris, M

    1993-03-01

    Twenty-eight spinal cord injured subjects who participated in an electrical stimulation bicycle ergometry home program were surveyed to determine perceived benefits, home exercise adherence, and predictors of continued home exercise with electrical stimulation. Subjects were classified as users or nonusers depending upon if they used the electrical stimulation ergometry on a regular basis in the home during the past four months. Nineteen subjects qualified as users and nine were nonusers. Ninety-five percent of the users cycled at least twice per week whereas the majority of the nonusers stopped regular home exercise within one month postclinic discharge. All subjects generally perceived increases in muscle bulk and endurance. Users and nonusers perceived inconsistent results related to spasticity. Minimal effects were noted with neurogenic pain and swelling. Adherence to the home exercise program was significantly related to sex of subject and pre-injury exercise habits. Results are discussed in relation to the costs and benefits of electrical stimulation bicycle ergometry in the home.

  8. The Bicycle Drawing Test: What Does It Measure in Developmentally Typical Children?

    Science.gov (United States)

    Cannoni, Eleonora; Di Norcia, Anna; Bombi, Anna Silvia; Di Giunta, Laura

    2015-10-01

    To verify the dimensionality of Bicycle Drawing Test (BDT), we applied the coding system of Greenberg, Rodriguez, and Sesta to bicycle drawings made by 295 boys and 320 girls (6-10 years old) with typical development, and submitted the data to item analysis, exploratory factor analysis, and confirmatory factor analysis. These analyses confirmed only two of the original four dimensions of the BDT: spatial reasoning and visual-motor control. The scores in these two factors were correlated with the Colored Progressive Matrices, the Rey Complex Figure (Copy and Memory) and with the teachers' ratings in mathematics, language, and drawing. The correlations, albeit moderate in magnitude, were consistent with the hypothesized convergent and discriminant validity. After checking for measurement invariance across gender and age, we conducted two analyses of variance, the first of which showed a significant difference between younger children (6-8 years old) and older children (9-10 years old); the analysis of variance by gender did not yield significant differences. These data enhance the usefulness of the BDT as a measure of separate cognitive components, but do not support its use as a measure of mechanical reasoning. PMID:25336037

  9. Solution and Structural Investigations of Ligand Preorganization in Trivalent Lanthanide Complexes of Bicyclic Malonamides

    Energy Technology Data Exchange (ETDEWEB)

    Parks, Bevin W.; Gilbertson, Robert D.; Hutchison, J. E.; Rather Healey, Elisabeth; Weakley, Timothy J R; Rapko, Brian M.; Hay, Benjamin P.; Sinkov, Sergei I.; Broker, Grant A.; Rogers, Robin D.

    2006-02-20

    This report describes an investigation into the coordination chemistry of trivalentlanthanides in solution and the solid state with acyclic and preorganized bicyclic malonamide ligands. Two experimental investigations were performed: solution bindingaffinities were determined through single-phase spectrophotometric titrations and the extent of conformational change upon binding was investigated with single-crystal X-raycrystallography. Both experimental methods compare the bicyclic malonamide (BMA), which is designed to be preorganized for binding trivalent lanthanides, to an analogousacyclic malonamide. Results from the spectrophotometric titrations indicate that BMA exhibits a 10-100 times increase in binding affinity to Ln(III) over acyclic malonamide.In addition, BMA forms compounds with high ligand-metal ratios, even when competing with water and nitrate ligands for binding sites. The crystal structures exhibit nosignificant differences in the nature of the binding between Ln(III) and the BMA or acyclic malonamide. These results support the conclusion that rational ligand design canlead to compounds that enhance the binding affinities within a ligand class.

  10. Energy cost and mechanical efficiency of riding a human-powered recumbent bicycle.

    Science.gov (United States)

    Capelli, Carlo; Ardigo, Luca Paolo; Schena, Federico; Zamparo, Paola

    2008-10-01

    When dealing with human-powered vehicles, it is important to quantify the capability of converting metabolic energy in useful mechanical work by measuring mechanical efficiency. In this study, net mechanical efficiency (eta) of riding a recumbent bicycle on flat terrain and at constant speeds (v, 5.1-10.0 m/s) was calculated dividing mechanical work (w, J/m) by the corresponding energy cost (C(c), J/m). w and C(c) increased linearly with the speed squared: w = 9.41 + 0.156 . v(2); C(c) = 39.40 + 0.563 . v(2). eta was equal to 0.257 +/- 0.0245, i.e. identical to that of concentric muscular contraction. Hence, i) eta seems unaffected by the biomechanical arrangement of the human-vehicle system; ii) the efficiency of transmission seems to be close to 100%, suggesting that the particular biomechanical arrangement does not impair the transformation of metabolic energy in mechanical work. When dealing with human-powered vehicles, it is important to quantify mechanical efficiency (eta) of locomotion. eta of riding a recumbent bicycle was calculated dividing the mechanical work to the corresponding energy cost of locomotion; it was practically identical to that of concentric muscular contraction (0.257 +/- 0.0245), suggesting that the power transmission from muscles to pedals is unaffected by the biomechanical arrangement of the vehicle.

  11. Long-term use of computerized bicycle ergometry for spinal cord injured subjects.

    Science.gov (United States)

    Sipski, M L; Alexander, C J; Harris, M

    1993-03-01

    Twenty-eight spinal cord injured subjects who participated in an electrical stimulation bicycle ergometry home program were surveyed to determine perceived benefits, home exercise adherence, and predictors of continued home exercise with electrical stimulation. Subjects were classified as users or nonusers depending upon if they used the electrical stimulation ergometry on a regular basis in the home during the past four months. Nineteen subjects qualified as users and nine were nonusers. Ninety-five percent of the users cycled at least twice per week whereas the majority of the nonusers stopped regular home exercise within one month postclinic discharge. All subjects generally perceived increases in muscle bulk and endurance. Users and nonusers perceived inconsistent results related to spasticity. Minimal effects were noted with neurogenic pain and swelling. Adherence to the home exercise program was significantly related to sex of subject and pre-injury exercise habits. Results are discussed in relation to the costs and benefits of electrical stimulation bicycle ergometry in the home. PMID:8439248

  12. A holistic approach to the integration of bicycle traffic into the urban landscape

    Directory of Open Access Journals (Sweden)

    Polonca Andrejčič Mušič

    2015-10-01

    Full Text Available Qualitative and quantitative indicators can be used to assess the quality of public space. The coherence of cycling infrastructure connectivity is an indicator of a public space's attractiveness as a basis for the quality of the bicycle traffic operation. We would like to find an optimal balance between the space's form and its image to provide good conditions for cycling as one of the most important forms of sustainable mobility, and consequently a factor facilitating a healthy lifestyle. The new approach brings a completely different view on planning cycling infrastructure, while rather than physical infrastructure characteristics, humans are placed at the forefront of the cycling infrastructure design as the most important measure of its quality. Since the complexity of human beings cannot be controlled with only one science or profession, solving the problem of bicycle traffic is not just a technical problem, but its design and management also lend a multidisciplinary character. From the perspective of different cycling infrastructure users, the study will define integrated multidisciplinary methodology for evaluating the quality of cycling infrastructure, which will equally include the criteria of sensing and perceiving of space. The new approach seeks a system of criteria, which enables the integrated planning of cycling infrastructure in all spatial, organizational, sectoral, and professional levels. All theoretical findings will be tested and demonstrated on the pilot case of the long-distance cycling connection in the area of four Slovenian coastal municipalities, namely Koper, Izola, Piran, and Ankaran.

  13. 150 bicycle injuries in children: a comparison with accidents due to other causes.

    Science.gov (United States)

    Illingworth, C M; Noble, D; Bell, D; Kemn, I; Roche, C; Pascoe, J

    1981-07-01

    One hundred and fifty bicycle accidents seen at the Children's Hospital Sheffield over a 6-month period from mid-August 1979 were analysed and 9.3 per cent of the cases were admitted. Twenty-two per cent had fractures, 20 per cent had soft tissue injuries of face or scalp, 8 children having damaged their teeth. Of the accidents 17.3 per cent were due to hitting an obstruction, 30.7 per cent were due to loss of control on a hill or corner and 8 per cent were of mechanical origin. Eighty-eight per cent had cycling experience of a year or more, and 32.7 per cent had had previous cycling accidents. Comparison with other types of accidents previously studied at the hospital, involving skateboards, playground equipment or road traffic accidents affecting child pedestrians, showed that by far the most serious were those involving child pedestrians. The injuries from bicycle accidents were similar in severity to those involving skateboards.

  14. Age Does Not Affect the Material Properties of Expanded Polystyrene Liners in Field-Used Bicycle Helmets.

    Science.gov (United States)

    Kroeker, Shannon G; Bonin, Stephanie J; DeMarco, Alyssa L; Good, Craig A; Siegmund, Gunter P

    2016-04-01

    Bicycle helmet foam liners absorb energy during impacts. Our goal was to determine if the impact attenuation properties of expanded polystyrene (EPS) foam used in bicycle helmets change with age. Foam cores were extracted from 63 used and unused bicycle helmets from ten different models spanning an age range of 2-20 yrs. All cores were impact tested at a bulk strain rate of 195 s(-1). Six dependent variables were determined from the stress-strain curve derived from each impact (yield strain, yield stress, elastic modulus, plateau slope, energy at 65% compression, and stress at 65% compression), and a general linear model was used to assess the effect of age on each dependent variable with density as a covariate. Age did not affect any of the dependent variables; however, greater foam density, which varied from 58 to 100 kg/m(3), generated significant increases in all of the dependent variables except for yield strain. Higher density foam cores also exhibited lower strains at which densification began to occur, tended to stay within the plateau region of the stress-strain curve, and were not compressed as much compared with the lower density cores. Based on these data, the impact attenuation properties of EPS foam in field-used bicycle helmets do not degrade with the age. PMID:26902784

  15. Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors.

    Science.gov (United States)

    Yan, Qi; Ding, Ning; Li, Yingxia

    2016-02-01

    A series of novel C-aryl glucosides containing dioxa-bicycle were synthesized and evaluated for inhibition activity against hSGLT2. Among the compounds tested, compound 6a showed moderate SGLT2 inhibition activities at 700 nM. The results could benefit the discovery of new SGLT2 inhibitors. PMID:26735747

  16. Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors

    DEFF Research Database (Denmark)

    Conti, Paola; Grazioso, Giovanni; di Ventimiglia, Samuele Joppolo;

    2005-01-01

    N1-substituted bicyclic pyrazole amino acids (S)-9a-9c and (R)-9a-9c, which are conformationally constrained analogues of glutamic acid, were prepared via a strategy based on a 1,3-dipolar cycloaddition. The new amino acids were tested for activity at ionotropic and metabotropic glutamate receptors...

  17. Examining the potential for modal change : motivators and barriers for bicycle commuting in Dar-es-Salaam

    NARCIS (Netherlands)

    Nkurunziza, A.; Zuidgeest, M.H.P.; Brussel, M.J.G.; Maarseveen, van M.F.A.M.

    2012-01-01

    The paper examines the effect of various motivators, barriers and policy related interventions (i.e., personal, social and physical–environmental factors) on bicycle commuting in Dares-Salaam, Tanzania. The research shows that these factors have different effects on people depending on the stage of

  18. Copper(II)-salt-promoted oxidative ring-opening reactions of bicyclic cyclopropanol derivatives via radical pathways

    OpenAIRE

    Hasegawa, Eietsu; Tateyama, Minami; Nagumo, Ryosuke; Tayama, Eiji; Iwamoto, Hajime

    2013-01-01

    Copper(II)-salt-promoted oxidative ring-opening reactions of bicyclic cyclopropanol derivatives were investigated. The regioselectivities of these processes were found to be influenced by the structure of cyclopropanols as well as the counter anion of the copper(II) salts. A mechanism involving rearrangement reactions of radical intermediates and their competitive trapping by copper ions is proposed.

  19. Copper(II-salt-promoted oxidative ring-opening reactions of bicyclic cyclopropanol derivatives via radical pathways

    Directory of Open Access Journals (Sweden)

    Eietsu Hasegawa

    2013-07-01

    Full Text Available Copper(II-salt-promoted oxidative ring-opening reactions of bicyclic cyclopropanol derivatives were investigated. The regioselectivities of these processes were found to be influenced by the structure of cyclopropanols as well as the counter anion of the copper(II salts. A mechanism involving rearrangement reactions of radical intermediates and their competitive trapping by copper ions is proposed.

  20. The effect of depressive symptomatology on plasma cortisol responses to acute bicycle exercise among post-menopausal women

    NARCIS (Netherlands)

    van der Pompe, G.; Bernards, N; Meijman, T.F.; Heijnen, C.J

    1999-01-01

    The present study was designed to elucidate the effect of depressive symptomatology on the cortisol response to strenuous exercise. Thirteen healthy, post-menopausal women participated in this study. The results show that acute bicycle exercise activates the hypothalamic-pituitary-adrenal (HPA) axis

  1. A Balanced Scorecard of Sustainable Management in the Taiwanese Bicycle Industry: Development of Performance Indicators and Importance Analysis

    Directory of Open Access Journals (Sweden)

    Chih-Chao Chung

    2016-05-01

    Full Text Available The main purpose of this study is to investigate the development of the performance indicators of sustainable management in the Taiwanese bicycle industry and to perform an importance analysis. Based on the Balanced Scorecard concept, the framework of sustainable management is added. Ten experts evaluated the performance indicators of a sustainable Balanced Scorecard in the Taiwanese bicycle industry using five major categories: (1 Financial, (2 Customer, (3 Internal Business Processes, (4 Learning and Growth, and (5 Sustainable Development, and a total of 21 performance indicators were used. The analytic network process (ANP was used to perform an importance analysis of the various performance indicators. Most of the experts suggested that for the introduction of a sustainable management strategy into the bicycle industry in Taiwan, it is necessary to include the definition of sustainable management and to improve five performance indicators: innovation process, customer satisfaction, operations process, after-sales service, and market share. According to the analysis results, this study proposed relevant management definitions and suggestions to be used as important references for decision-makers to understand the introduction of sustainable management strategies to the current bicycle industry in Taiwan.

  2. Helmet use among users of the Citi Bike bicycle-sharing program: a pilot study in New York City.

    Science.gov (United States)

    Basch, Corey H; Ethan, Danna; Rajan, Sonali; Samayoa-Kozlowsky, Sandra; Basch, Charles E

    2014-06-01

    The use of bicycle helmets to prevent or reduce serious head injuries is well established. However, it is unclear how to effectively promote helmet use, particularly in the context of bicycle-sharing programs. The need to determine rates of helmet use specifically among users of bicycle-sharing programs and understand if certain characteristics, such as time of day, affect helmet use, is imperative if effective promotion and/or legislative efforts addressing helmet use are to be developed. We estimated the prevalence of helmet use among a sample of Citi Bike program users in New York City. A total of 1,054 cyclists were observed over 44 h and across the 22 busiest Citi Bike locations. Overall, 85.3% (95% CI 82.2, 88.4%) of the cyclists observed did not wear a helmet. Rates of helmet non-use were also consistent whether cyclists were entering or leaving the docking station, among cyclists using the Citi Bikes earlier versus later in the day, and among cyclists using the Citi Bikes on weekends versus weekdays. Improved understanding about factors that facilitate and hinder helmet use is needed to help reduce head injury risk among users of bicycle sharing programs.

  3. Bicycle helmets.

    OpenAIRE

    2012-01-01

    One third of the cyclists who are admitted to hospital with serious injury after a road crash are diagnosed with head or brain injury. Approximately three-quarters of the head and brain injuries among cyclists are caused by crashes that do not involve motorized traffic; as many as nine out of ten young children who sustain head/brain injury, do so in crashes not involving motor vehicles. These are mostly cyclist-only crashes. This type of crash is difficult to prevent, but it is possible to l...

  4. Bicycle helmets.

    NARCIS (Netherlands)

    2012-01-01

    One third of the cyclists who are admitted to hospital with serious injury after a road crash are diagnosed with head or brain injury. Approximately three-quarters of the head and brain injuries among cyclists are caused by crashes that do not involve motorized traffic; as many as nine out of ten yo

  5. Interactive bicycle

    CERN Multimedia

    Measure your power : VOLTMETER x AMPMETER = electric power generated in Watts Pedal power! The force from your legs turns the back wheel which is connected to an alternator. This generates a voltage and current which lights the bulbs. The faster you pedal, the more light there is. Have a go and measure your power!. To generate a kilowatt hour of energy, you would need to produce 1000 Watts continuously for an hour. Where does the energy come from to move your legs? After several minutes of pedalling, the body starts to use the chemical energy stored in your fat. Did you know? On a clear day, the power of sunlight is enough to light twenty 50W lightbulbs per square metre!

  6. Conformational Preference and Donor Atom Interaction Leading to Hexacoordination vs Pentacoordination in Bicyclic Tetraoxyphosphoranes(1).

    Science.gov (United States)

    Sherlock, David J.; Chandrasekaran, A.; Prakasha, T. K.; Day, Roberta O.; Holmes, Robert R.

    1998-01-12

    New bicyclic tetraoxyphosphoranes all containing a six-membered oxaphosphorinane ring, C(6)H(8)(CH(2)O)(2)P(OC(12)H(8))(OXyl) (1), (C(6)H(4)O)(2)P(OC(12)H(8))(OXyl) (2), CH(2)[(t-Bu)(2)C(6)H(2)O](2)P(OC(12)H(8))(OXyl) (3), O(2)S[(t-Bu)MeC(6)H(2)O](2)P(OC(12)H(8))(OXyl) (4), and S[(t-Bu)MeC(6)H(2)O](2)P(OC(12)H(8))(OXyl) (5), were synthesized by the oxidative addition reaction of the cyclic phosphine P(OC(12)H(8))(OXyl) (6) with an appropriate diol in the presence of N-chlorodiisopropylamine. X-ray analysis revealed trigonal bipyramidal (TBP) geometries for 1-4 where the dioxa ring varied in size from six- to eight-membered. With a sulfur donor atom as part of an eight-membered ring in place of a potential oxygen donor atom of a sulfone group as in 4, the X-ray study of 5 showed the formation of a hexacoordinated structure via a P-S interaction. Ring constraints are evaluated to give an order of conformational flexibility associated with the (TBP) tetraoxyphosphoranes 4 > 3 approximately 1 > 2 which parallels the degree of shielding from (31)P NMR chemical shifts: 4 > 3 > 1 > 2. The six- and seven-membered dioxa rings in 1 and 2, respectively, are positioned at axial-equatorial sites, whereas the eight-membered dioxa ring in 3 and 4 occupies diequatorial sites of a TBP. V-T (1)H NMR data give barriers to xylyl group rotation about the C-OXyl bond. The geometry of 5 is located along a coordinate from square pyramidal toward octahedral to the extent of 60.7%. Achieving hexacoordination in bicyclic tetraoxyphosphoranes of reduced electrophilicity relative to bicyclic pentaoxyphosphoranes appears to be dependent on the presence of a sufficiently strong donor atom.

  7. Health effects of the London bicycle sharing system: health impact modelling study

    Science.gov (United States)

    Tainio, Marko; Cheshire, James; O’Brien, Oliver; Goodman, Anna

    2014-01-01

    Objective To model the impacts of the bicycle sharing system in London on the health of its users. Design Health impact modelling and evaluation, using a stochastic simulation model. Setting Central and inner London, England. Data sources Total population operational registration and usage data for the London cycle hire scheme (collected April 2011-March 2012), surveys of cycle hire users (collected 2011), and London data on travel, physical activity, road traffic collisions, and particulate air pollution (PM2.5, (collected 2005-12). Participants 578 607 users of the London cycle hire scheme, aged 14 years and over, with an estimated 78% of travel time accounted for by users younger than 45 years. Main outcome measures Change in lifelong disability adjusted life years (DALYs) based on one year impacts on incidence of disease and injury, modelled through medium term changes in physical activity, road traffic injuries, and exposure to air pollution. Results Over the year examined the users made 7.4 million cycle hire trips (estimated 71% of cycling time by men). These trips would mostly otherwise have been made on foot (31%) or by public transport (47%). To date there has been a trend towards fewer fatalities and injuries than expected on cycle hire bicycles. Using these observed injury rates, the population benefits from the cycle hire scheme substantially outweighed harms (net change −72 DALYs (95% credible interval −110 to −43) among men using cycle hire per accounting year; −15 (−42 to −6) among women; note that negative DALYs represent a health benefit). When we modelled cycle hire injury rates as being equal to background rates for all cycling in central London, these benefits were smaller and there was no evidence of a benefit among women (change −49 DALYs (−88 to −17) among men; −1 DALY (−27 to 12) among women). This sex difference largely reflected higher road collision fatality rates for female cyclists. At older ages the modelled

  8. Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Zbynek Heger

    2016-03-01

    Full Text Available Herein, we present a study focused on the determination of the influence of long-distance (53 km bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa biomarkers total prostate-specific antigen (tPSA, free PSA (fPSA and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively, lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L and C-reactive protein (p = 0.01, 0.0–0.01 mg/L. It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL. Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine. Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA.

  9. Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer.

    Science.gov (United States)

    Heger, Zbynek; Gumulec, Jaromir; Ondrak, Ales; Skoda, Jan; Zitka, Zdenek; Cernei, Natalia; Masarik, Michal; Zitka, Ondrej; Adam, Vojtech

    2016-01-01

    Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49-57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0-0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa-sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA. PMID:26999116

  10. Solar battery powered bicycle lamp SKL050. Final report; Solar/Akkufahrradleuchte SKL050. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Lang, O.

    2001-06-01

    Up to now there are no functional or high quality mobile solar powered chargers and lamps available for the outdoor and bicycle consumer. Hence the project SKL050 was concerned with the development of a novel combination of battery powered multi-functional lamp and solar charger. All components such as solar module, bulb, electronics and housing were supposed to be involved in the development. The goal was a ready-for-production development well placed in the field of high quality bicycle, camping and household appliances by efficient, well matched components and an exclusive and functional design. Another issue in the development was a cost effective production by automated assembling in order to maintain the maximum customer price of 129,- DM (incl. VAT). Most of the stated goals were reached at the end of the project. Only the detailed construction of the housing parts and final approvals have to be carried out by a bicycle accessories company which is interested to produce and market the SKL050 in licence. Apart from the product SKL050 several important results regarding automation processes of small solar modules have been collected and are supposed to be integrated in future products of the SOLARC GmbH. (orig.) [German] Im Bereich mobiler solarbetriebener Ladegeraete und Leuchten fuer den Outdoor- und Fahrradkonsumenten sind bislang keine funktionell oder aesthetisch brauchbaren Produkte verfuegbar. Das Vorhaben SKL050 umfasste daher gezielt die Entwicklung einer neuartigen Kombination aus akkubetriebener Mehrzweckleuchte und Solar-Akkulader. Saemtliche Basiskomponenten wie Solarmodul, Leuchtmittel, Elektronik und Gehaeuse sollten mit in die Entwicklung einbezogen werden. Ziel des Vorhabens war ein zur Serienreife entwickeltes Produkt, welches durch leistungsfaehige, optimal aufeinander abgestimmte Komponenten sowie durch ein exklusives und funktionelles Design einen Platz im Bereich der hochwertigen Fahrrad-, Camping-, und Haushaltsaccessoires findet. Bei

  11. Emergency department coding of bicycle and pedestrian injuries during the transition from ICD-9 to ICD-10

    Science.gov (United States)

    Karkhaneh, M; Hagel, B E; Couperthwaite, A; Saunders, L D; Voaklander, D C

    2011-01-01

    Background The international classification of diseases version 10 (ICD-10) uses alphanumeric expanded codes and external cause of injury codes (E-codes). Objective To examine the reliability and validity of emergency department (ED) coders in applying E-codes in ICD-9 and -10. Methods Bicycle and pedestrian injuries were identified from the ED information system from one period before and two periods after transition from ICD-9 to -10 coding. Overall, 180 randomly selected bicycle and pedestrian injury charts were reviewed as the reference standard (RS). Original E-codes assigned by ED coders (ICD-9 in 2001 and ICD-10 in 2004 and 2007) were compared with charts (validity) and also to ICD-9 and -10 codes assigned from RS chart review, to each case by an independent (IND) coder (reliability). Sensitivity, specificity, simple, and chance-corrected agreements (κ statistics) were calculated. Results Sensitivity of E-coding bicycle injuries by the IND coder in comparison with the RS ranged from 95.1% (95% CI 86.3 to 99.0) to 100% (95% CI 94.0 to 100.0) for both ICD-9 and -10. Sensitivity of ED coders in E-coding bicycle injuries ranged from 90.2% (95% CI 79.8 to 96.3) to 96.7% (95% CI 88.5 to 99.6). The sensitivity estimates for the IND coder ranged from 25.0% (95% CI 14.7 to 37.9) to 45.0% (95% CI 32.1 to 58.4) for pedestrian injuries for both ICD-9 and -10. Conclusion Bicycle injuries are coded in a reliable and valid manner; however, pedestrian injuries are often miscoded as falls. These results have important implications for injury surveillance research. PMID:21705466

  12. Theoretical Studies on the Thermodynamic Properties and Detonation Performances of Bicyclic Nitramines: TNAD Isomers

    Institute of Scientific and Technical Information of China (English)

    QIU Ling; XIAO He-Ming; GONG Xue-Dong; JU Xue-Hai

    2006-01-01

    Ab initio molecular orbital calculations have been performed at Hartree-Fock (HF), second-order Mōller-Plesset (MP2), and hybrid density functional theory (DFT) B3LYP levels with 6-31G** basis set to investigate the low sensitive explosive trans-1,4,5,8-tetranitro-1,4,5,8- tetraazadecalin (TNAD) and its seven bicyclic isomers. Their molecular geometries, electronic structures, thermodynamic properties, and detonation performances were predicted and compared. The relationships between structures and various properties were discussed in detail. The calculated results agree well with the available experimental data, and suggest that some compounds may be novel potential candidates of high energy density materials (HEDMs) with performances better than TNT (2,4,6-trinitrotoluene) and similar to RDX (1,3,5-trinitro-1,3,5-triazacyclohexane).

  13. Including Accident Information in Automatic Bicycle Route Planning for Urban Areas

    Directory of Open Access Journals (Sweden)

    Alex D. Singleton

    2011-01-01

    Full Text Available Between 2005 and 2007 there were 9071 traffic accidents involving bicycles within London and this paper demonstrates the utility of Geographic Information Systems as a tool for analysing and visualising these occurrences. Through linkage of these spatial locations to a street network dataset it was possible to create a variety of intelligence about the types of street infrastructure where accidents predominantly occur. Additionally, a network routing algorithm was adapted to account for the frequency of accidents within a series of proposed journeys. This pilot routing application compared the quickest route with an accident avoidance weighted route between a series of origins and destinations. The results demonstrated that the routes avoiding areas of high accident volume did not increase journey length significantly; however they did provide a “safer” route based on empirical evidence over the volume of accident locations.

  14. A concealed small bowel perforation in an adult secondary to bicycle handlebar trauma

    Science.gov (United States)

    Nolan, GJ; Simpson, RR

    2013-01-01

    Traumatic abdominal wall hernia (TAWH) secondary to bicycle handlebar is a rare injury. The majority of the literature describes abdominal wall herniation in children. We present a rare case of TAWH in an adult with a concealed small bowel perforation. Although clinical examination in conjunction with computed tomography can exclude the majority of solid organ injuries, small bowel injuries can often be missed. Our case initially revealed a serosal tear in the small bowel but, on close inspection, a separate 3mm perforation was identified, hidden in the small bowel mesentery. We strongly support a low threshold for operative intervention if there is any suspicion. Moreover, we stress the importance of meticulous examination during laparotomy as this injury could have been easily missed, resulting in potential morbidity or mortality in a patient sustaining such an injury. PMID:23676803

  15. Commuter Transport Mode Choice and Typologies in the Bicycle City Copenhagen

    DEFF Research Database (Denmark)

    Olesen, Anne Vingaard; Kjems, Erik; Reinau, Kristian Hegner;

    2016-01-01

    Bicycle Cities” such as Copenhagen can serve as role models: how far can we push the commuter modal shares in the direction of more sustainable transport? This paper presents a study that aims to give a state-of-the-art picture of a Copenhagen that provides wide cycling highways and the politica...... restricted our analysis to commuters both living and working within the city center. The characterization of these commuter types was strikingly short of personal attitudes about environmental concerns....... transport and car use. Furthermore, we derived a typology of four commuter types: “cyclists because of short distances” (40 percent), ”commuters by car or public transport out of necessity” (35 percent), ”more eco-oriented cyclists and others” (16 percent) and ”passionate motorists” (8 percent) when we...

  16. Compliant mechanism road bicycle brake: a rigid-body replacement case study

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, Brian M [Los Alamos National Laboratory; Howell, Larry L [NON LANL; Magleby, Spencer P [NON LANL

    2011-01-19

    The design of high-performance bicycle brakes is complicated by the competing design objectives of increased performance and low weight. But this challenge also provides a good case study to demonstrate the design of compliant mechanisms to replace current rigid-link mechanisms. This paper briefly reviews current road brake designs, demonstrates the use of rigid-body replacement synthesis to design a compliant mechanism, and illustrates the combination of compliant mechanism design tools. The resulting concept was generated from the modified dual-pivot brake design and is a partially compliant mechanism where one pin has the dual role of a joint and a mounting pin. The pseudo-rigid-body model, finite element analysis, and optimization algorithms are used to generate design dimensions, and designs are considered for both titanium and E-glass flexures. The resulting design has the potential of reducing the part count and overall weight while maintaining a performance similar to the benchmark.

  17. A simple, enaminone-based approach to some bicyclic pyridazinium tetrafluoroborates

    Directory of Open Access Journals (Sweden)

    František Josefík

    2013-07-01

    Full Text Available Easily obtainable cyclic enaminones (piperidin-2-ylidenealkanones can be transformed into substituted bicyclic pyridazinium tetrafluoroborates upon treatment with corresponding diazonium salts. The transformation can be performed either in a one-pot way or in a two-step process with the isolation of single azo-coupled enaminone as the intermediate. The former method is superior. Under the optimized conditions, a number of pyridazinium salts substituted with both electron-donating and electron-withdrawing substituents was easily synthesized. A mechanism of the formation of the pyridazinium salts is suggested. A partial drawback is the possibility of the formation of a mixture of products when using a different diazonium salt in each step due to a reversibility of the azo coupling. This can be suppressed by using a more reactive diazonium salt before a less reactive one.

  18. Laser dye stability. Pt. 4. Photodegradation relationships for bicyclic dyes in alcohol solutions

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, A.N. (Naval Weapons Center, China Lake, Calif. (USA). Research Dept.)

    1978-05-01

    Changes in the absorption of a dye laser solution are examined after excitation with a xenon flashlamp. It is found that the rate of bleaching as a function of the total input energy of coumarin or quinolone dyes in ethanol increases in direct proportion to the dye concentration. This relationship suggests that the dye reacts with a photoproduct of the solvent rather than being directly decomposed by the xenon flash. We have measured the conversion of the dye to form products, P, absorbing at the lasing wavelength. Results correspond to the dye reacting with a precursor of P to form either insoluble products or ones not absorbing at the lasing wavelength. Thus larger total amounts of bleached dye do not proportionately increase P, and hence do not proportionately inhibit lasing. Furthermore, we find that P increases with the total input energy fairly independent of the rate of bleaching for a given bicyclic dye in an alcohol solution.

  19. Universal flow-density relation of single-file bicycle, pedestrian and car motion

    CERN Document Server

    Zhang, Jun; Holl, Stefan; Boltes, Maik; Andresen, Erik; Schadschneider, Andreas; Seyfried, Armin

    2013-01-01

    The relation between flow and density, also known as the fundamental diagram, is an essential quantitative characteristic to describe the efficiency of traffic systems. We have performed experiments with single-file motion of bicycles and compare the results with previous studies for car and pedestrian motion in similar setups. In the space-time diagrams we observe three different states of motion (free flow state, jammed state and stop-and-go waves) in all these systems. Despite of their obvious differences they are described by a universal fundamental diagram after proper rescaling of space and time which takes into account the size and free velocity of the three kinds of agents. This indicates that the similarities between the systems go deeper than expected.

  20. Visual guidance during bicycle steering through narrow lanes: a study in children.

    Science.gov (United States)

    Vansteenkiste, Pieter; Cardon, Greet; Lenoir, Matthieu

    2015-05-01

    Recently, Vansteenkiste et al. (2013) explored how visual behaviour guides bicycle steering when cycling at different speeds through 15m long lanes of 10, 25 and 40cm wide. Participants were found to shift their gaze direction towards the end of the lanes at higher speeds, towards the near pathway on narrow lanes and more towards irrelevant areas on wider lanes. To investigate to what extent young learner bicyclists adapt their visual behaviour in a similar way as adults, the experiment was repeated with seven eight-year-old children, and results were compared to the adult data. Children were found to cycle slower through narrow lanes than adults. However, with increasing lane width and cycling speed, children made the same shifts of visual gaze direction as the adults. These results suggest that for a simple precision steering task, children are able to adopt a similar visual-motor strategy as adults, provided that they cycle at their own pace. PMID:25725423

  1. Universal flow-density relation of single-file bicycle, pedestrian and car motion

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, J., E-mail: ju.zhang@fz-juelich.de [Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, 52425 Jülich (Germany); Mehner, W., E-mail: w.mehner@fz-juelich.de [Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, 52425 Jülich (Germany); Holl, S., E-mail: st.holl@fz-juelich.de [Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, 52425 Jülich (Germany); Boltes, M., E-mail: m.boltes@fz-juelich.de [Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, 52425 Jülich (Germany); Andresen, E., E-mail: e.andresen@uni-wuppertal.de [Department of Computer Simulation for Fire Safety and Pedestrian Traffic, Bergische Universität Wuppertal, 42285 Wuppertal (Germany); Schadschneider, A., E-mail: as@thp.uni-koeln.de [Institut für Theoretische Physik, Universität zu Köln, 50937 Köln (Germany); Seyfried, A., E-mail: a.seyfried@fz-juelich.de [Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, 52425 Jülich (Germany); Department of Computer Simulation for Fire Safety and Pedestrian Traffic, Bergische Universität Wuppertal, 42285 Wuppertal (Germany)

    2014-09-12

    The relation between flow and density is an essential quantitative characteristic to describe the efficiency of traffic systems. We have performed experiments with single-file motion of bicycles and compared the results with previous studies for car and pedestrian motion in similar setups. In the space–time diagrams we observe three different states of motion (free flow state, jammed state and stop-and-go waves) in all these systems. Despite their obvious differences they are described by a universal fundamental diagram after proper rescaling of space and time which takes into account the size and free velocity of the three kinds of agents. This indicates that the similarities between the systems go deeper than expected.

  2. Deciphering characteristics of bicyclic aromatics--mediators for reductive decolorization and bioelectricity generation.

    Science.gov (United States)

    Xu, Bin; Chen, Bor-Yann; Hsueh, Chung-Chuan; Qin, Lian-Jie; Chang, Chang-Tang

    2014-07-01

    This first-attempt study quantitatively assessed electron-mediating characteristics of bicyclic aromatics - 1-amino-2-naphthol, 4-amino-1-naphthol (i.e., decolorized intermediates of azo dyes - orange I and II) for color removal and power generation in MFCs. According to cyclic-voltammetric profiles, the presence of reduction and oxidation peak potentials clearly suggested a crucial role of these intermediates as electron-shuttling mediators. Shake-flask cultures also showed that appropriate accumulation of 1A2N, 4A1N apparently enhanced color-removal efficiencies of bacterial decolorization. This study clearly suggested that suitable supplementation of electrochemically active electron shuttle(s) to dye-bearing MFCs is a promising strategy to stimulate reductive decolorization and bioelectricity generation.

  3. Systemic and forearm vascular resistance changes after upright bicycle exercise in man.

    Science.gov (United States)

    Coats, A J; Conway, J; Isea, J E; Pannarale, G; Sleight, P; Somers, V K

    1989-06-01

    1. Blood pressure, cardiac function and forearm blood flow following voluntary maximal upright bicycle exercise were studied in thirteen normal volunteers in a cross-over design against a control day. 2. After exercise there was a short-lived (5-10 min) increase in systolic blood pressure, peak aortic blood velocity and aortic acceleration suggesting a persistence of the positive inotropic influence of exercise. 3. Systemic vasodilation, which was seen immediately exercise stopped, lasted at least 60 min. This was associated with a reduction in diastolic blood pressure for the whole hour. After 30 min systolic blood pressure was also reduced. Heart rate and cardiac output were still significantly elevated and systemic vascular resistance still reduced at 60 min post-exercise. 4. A non-exercising limb vascular bed (forearm) showed a marked vasodilation for 1 h after predominately leg exercise indicating the presence of a vasodilatory influence affecting vascular beds other than the exercising muscle groups. PMID:2600851

  4. “This bicycle gives me a headache”, a congenital anomaly

    Science.gov (United States)

    2013-01-01

    Backround The combination of a presacral mass, a sacral bone deformity, and an anorectal malformation are also known as the Currarino triad or Currarino syndrome. The syndrome is associated with a very high rate of severe and intractable constipation and urinary incontinence. However, it can also result in less common complaints and symptoms. Although the syndrome is known since 1981 and the involved genes are clarified to a great extent, the diagnosis may be delayed or missed if unrecognized. Case presentation A 24-year old female presented with periodical headaches. She was born with an imperforate anus, absent rectum and colon, double bladder, and sacral defect. Soon after birth she underwent several surgical procedures for anorectal and bladder reconstructions. The patient now came to her pediatric urologist for urinary incontinence and mentioned severe headaches on the side, particularly when riding a bike. Finally, she solved her headache problem by stopping to ride her bicycle. On physical examination no abnormalities were found except the ileostomy that was present ever since soon after birth and her urinary incontinence. Blood tests showed no abnormalities. Additional MRI showed a large and previously not known anterior meningocele at the level of the sacrum. Surgical treatment consisted of closure of the dura by posterior approach. Conclusion In this case report we describe the late discovery with an atypical presentation of an anterior meningocele in a young adult with urinary incontinence, a sacral defect, an anorectal malformation and headaches during bicycle riding. After surgical treatment of our patient the meningocele regressed. Three months after successful surgery she had no complaints and was able to ride a bike again. PMID:24124700

  5. Driver behavior during bicycle passing maneuvers in response to a Share the Road sign treatment.

    Science.gov (United States)

    Kay, Jonathan J; Savolainen, Peter T; Gates, Timothy J; Datta, Tapan K

    2014-09-01

    The interaction of motorists and bicyclists, particularly during passing maneuvers, is an area of concern to the bicycle safety community as there is a general perception that motor vehicle drivers may not share the road effectively with bicyclists. This is a particular concern on road sections with centerline rumble strips where motorists are prone to crowd bicyclists during passing events. One potential countermeasure to address this concern is the use of a bicycle warning sign with a "Share the Road" plaque. This paper presents the results of a controlled field evaluation of this sign treatment, which involved an examination of driver behavior while overtaking bicyclists. A series of field studies were conducted concurrently on two segments of a high-speed, rural two-lane highway. These segments were similar in terms of roadway geometry, traffic volumes, and other relevant factors, except that one of the segments included centerline rumble strips while the other did not. A before-and-after study design was utilized to examine changes in motor vehicle lateral placement and speed at the time of the passing event as they relate to the presence of centerline rumble strips and the sign treatment. Centerline rumble strips generally shifted vehicles closer to the bicyclists during passing maneuvers, though the magnitude of this effect was marginal. The sign treatment was found to shift motor vehicles away from the rightmost lane positions, though the signs did not significantly affect the mean buffer distance between the bicyclists and passing motorists or the propensity of crowding events during passing. The sign treatment also resulted in a 2.5miles/h (4.0km/h) reduction in vehicle speeds. Vehicle type, bicyclist position, and the presence of opposing traffic were also found to affect lateral placement and speed selection during passing maneuvers. PMID:24705278

  6. Prediction of oxygen uptake on a bicycle wind-loaded simulator.

    Science.gov (United States)

    Dengel, D R; Graham, R E; Jones, M T; Norton, K I; Cureton, K J

    1990-08-01

    The primary purpose of this study was to determine the accuracy of estimating oxygen uptake (VO2) from the flywheel revolution rate of a bicycle wind-loaded simulator. VO2 at four different flywheel revolution rates was measured on a Findlay Road Machine (FRM). Ten male trained cyclists, 10 male untrained cyclists, 10 female trained cyclists and 10 female untrained cyclists served as subjects. Significant curvilinear relationships (P less than 0.01) were found between road speed estimated from flywheel revolution rate and VO2 expressed as 1.min-1, ml.kg-1.min-1, 1.min-1.m-2 (r = 0.97, 0.96, 0.98, respectively). The absolute standard error of the mean VO2 was 0.21 l.min-1 (9.6%), 3.71 ml.kg-1.min-1 (11.5%) and 0.10 l.min-1.m-2 (7.9%), respectively. The relationship between VO2 and speed was similar to that reported during road cycling. To determine the magnitude of between-machine differences in VO2, six subjects randomly performed cycling using two different FMR. Significant (P less than 0.05) differences between machines were found at only the highest speed. The present study indicates that it is possible to accurately predict VO2 from flywheel revolution rate using a FRM. Since the FRM appears to approximate the resistance a cyclist experiences on the road and allows cyclists to use their own bicycle, it provides a good alternative to traditional laboratory ergometers.

  7. Analysis of the Influencing Factors of the Public Willingness to Participate in Public Bicycle Projects and Intervention Strategies—A Case Study of Jiangsu Province, China

    Directory of Open Access Journals (Sweden)

    Ranran Yang

    2016-04-01

    Full Text Available In this study, factors influencing the willingness to participate in public bicycle projects were analyzed using the binary logistic model. The study builds on a broad and practical conceptual framework that embraces four dimensions of influencing factors, including household demographic, psychological, external, and public bicycle variables. The empirical results are based on a questionnaire survey that was sent to 520 urban residents in Xuzhou, Taizhou, and Suzhou in Jiangsu province. The survey indicates that environmental responsibility, improvement of the public transport system, health and safety considerations in relation to public bicycles, and environmental crisis consciousness have appreciable impacts upon the willingness to participation in public bicycle projects. The first three of these have a positive impact, whereas the last (environmental crisis consciousness has a negative impact. Consequently, some policy suggestions are proposed.

  8. New and Concise Syntheses of the Bicyclic Oxamazin Core Using an Intramolecular Nitroso Diels-Alder Reaction and Ring-Closing Olefin Metathesis

    Science.gov (United States)

    Watson, Kyle D.; Carosso, Serena

    2013-01-01

    Herein two new and concise synthetic approaches for making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels-Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the second fused ring of the core. The scope of the second approach was also expanded further to afford larger ringed bicyclic systems. PMID:23276301

  9. New and concise syntheses of the bicyclic oxamazin core using an intramolecular nitroso Diels-Alder reaction and ring-closing olefin metathesis.

    Science.gov (United States)

    Watson, Kyle D; Carosso, Serena; Miller, Marvin J

    2013-01-18

    Herein two new and concise synthetic approaches for making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels-Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the second fused ring of the core. The scope of the second approach was also expanded further to afford larger ringed bicyclic systems.

  10. 中国电动自行车市场结构分析%Analysis of China electric bicycle market structure

    Institute of Scientific and Technical Information of China (English)

    杜小蓉

    2011-01-01

    the paper discusses the electric bicycle market development on the base of analysis of China electric bicycle market structure according to the Western industrial organization theory.%本文在以西方产业组织理论对我国电动自行车市场结构进行分析的的基础上,对未来电动自行车市场的发展进行了探讨。

  11. ‘Cycle Thieves, We Are Watching You’: Impact of a Simple Signage Intervention against Bicycle Theft

    Science.gov (United States)

    Nettle, Daniel; Nott, Kenneth; Bateson, Melissa

    2012-01-01

    Background Bicycle theft is a serious problem in many countries, and there is a lack of evidence concerning effective prevention strategies. Displaying images of ‘watching eyes’ has been shown to make people behave in more socially desirable ways in a number of settings, but it is not yet clear if this effect can be exploited for purposes of crime prevention. We report the results of a simple intervention on a university campus where signs featuring watching eyes and a related verbal message were displayed above bicycle racks. Methodology and Principal Findings We installed durable signs at three locations which had experienced high levels of bicycle theft, and used the rest of the university campus as a control location. Reported thefts were monitored for 12 months before and after the intervention. Bicycle thefts decreased by 62% at the experimental locations, but increased by 65% in the control locations, suggesting that the signs were effective, but displaced offending to locations with no signs. The Odds Ratio for the effect of the intervention was 4.28 (95% confidence interval 2.04–8.98), a large effect compared to other place-based crime prevention interventions. Conclusions and Significance The effectiveness of this extremely cheap and simple intervention suggests that there can be considerable crime-reduction benefits to engaging the psychology of surveillance, even in the absence of surveillance itself. Simple interventions for high-crime locations based on this principle should be considered as an adjunct to other measures, although a possible negative consequence is displacement of offending. PMID:23251615

  12. Policies in favor of the bicycle development.; Politiques en faveur du developpement du velo. Bonnes pratiques de villes europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Vallar, J.P.; Kerveillan, A.

    2001-07-01

    This study presents, ten cases of european towns which realized a policy in favor of the bicycle development. With the incitation to the displacement on foot and the public transportation, it is a good and efficient way of environmental quality. For each case, the following points are presented: global policy of the local government, technical aspects and organization, economic, environmental aspects and behavior, future orientations and contacts. (A.L.B.)

  13. Safety aspects of the bicycle traffic and the needs of cyclists in the City of Zagreb and its surrounding

    Directory of Open Access Journals (Sweden)

    Sindik Joško

    2015-01-01

    Full Text Available The goals of this study were: to determine the possibility of forecasting for the preferences of cycling on the basis of all relevant factors Zagreb cycling (1 and to determine the differences between the participants in all the relevant factors in Zagreb cycling, by gender, in relation to membership in the Association "Trad Union of bicyclists", type of cycling and part of the city where cyclists live (2. Over 3000 members of the Association and cyclists who are not members of the Association ("average" cyclist are tested, using conveniently assembled questionnaire. It turned out that latent dimensions of the sub-questionnaires well represented themes: barriers to cycling, the role of the City in bicycle traffic, the purpose of using bicycle accident during bicycle traffic. People who are more inclined to participate in city traffic riding, often believe that the City should significantly improve conditions for cycling, tend to safer driving and more negative estimate lack of road cycling conditions in Zagreb. Women and members of the Union of cyclists often feel that the City should improve conditions for cycling and negatively evaluate the existing conditions of cycling, more often use the bike for different purposes and had frequent accidents bicycle. In the northern part of the city, Samobor, Zaprešić and Sesvete, Dugo Selo and Ivanja Reka participants were assessed to have the most adverse road conditions for cycling, while the wider center of Zagreb currently has the most favorable conditions for cycling. The results provide the guidance for improving the safety of the cycling in Zagreb and its surrounding, for taking constructive social actions at the state level and on the local-community level, as well as in the broader context of sustainable development.

  14. On-bicycle exposure to particulate air pollution: Particle number, black carbon, PM2.5, and particle size

    Science.gov (United States)

    Hankey, Steve; Marshall, Julian D.

    2015-12-01

    Inhalation of air pollution during transport is an important exposure pathway, especially for certain modes of travel and types of particles. We measured concentrations of particulate air pollution (particle number [PN], black carbon [BC], fine particles [PM2.5], particle size) using a mobile, bicycle-based monitoring platform during morning and afternoon rush-hour to explore patterns of exposure while cycling (34 days between August 14 and October 16, 2012 in Minneapolis, MN). Measurements were geo-located at 1 ​s intervals along 3 prescribed monitoring routes totaling 85 h (1426 km) of monitoring. Mean morning [afternoon] on-road concentrations were 32,500 [16,600] pt cm-3, 2.5 [0.7] μg m-3 BC, 8.7 [8.3] μg m-3 PM2.5, and 42 [39] nm particle diameter. Concentrations were correlated with street functional class and declined within small distances from a major road (e.g., for PN and BC, mean concentration decreased ∼20% by moving 1 block away from major roads to adjacent local roads). We estimate the share of on-bicycle exposure attributable to near-traffic emissions (vs. regional pollution) is ∼50% for PN and BC; ∼25% for PM2.5. Regression models of instantaneous traffic volumes, derived from on-bicycle video recordings of nearby traffic, quantify the increase in particle-concentrations associated with each passing vehicle; for example, trucks were associated with acute, high concentration exposure events (average concentration-increase per truck: 31,000 pt cm-3, 1.0 μg m-3 PM2.5, 1.6 μg m-3 BC). Our findings could be used to inform design of low-exposure bicycle networks in urban areas.

  15. Teste de Conconi adaptado para bicicleta aquática Conconi test adapted to aquatic bicycle

    Directory of Open Access Journals (Sweden)

    Jonas Neves Martins

    2007-10-01

    Full Text Available A prática regular de exercícios físicos tem sido considerada um dos mecanismos que auxiliam a melhoria de padrões da saúde e de qualidade de vida. Em conseqüência do crescimento da procura por academias de ginástica, as atividades físicas no meio líquido, com destaque para a bicicleta aquática, têm aumentado nos últimos anos. No entanto, há ainda carência de métodos para a avaliação e prescrição do treinamento aeróbio neste tipo de equipamento. O objetivo deste estudo foi propor uma adaptação do teste de Conconi et al. (1982 para bicicleta aquática. Foram testados 27 participantes (24 ± 6 anos, 171 ± 8cm, 66 ± 12kg 15 do sexo masculino e 12 do feminino. Os participantes foram submetidos a um teste progressivo, realizado em bicicleta aquática, com carga inicial de 50RPM e incremento de 3RPM a cada minuto, até a exaustão. A FC foi registrada durante todo o teste. Para análise dos dados, foi utilizada estatística descritiva e o teste "t" de Student (P Physical exercise has been considered one of the mechanisms that improve health and quality of life. As a consequence of the enhanced demand for fitness centers, physical activities in liquid environment, especially aquatic cycling, have increased in the last years. However, methods of assessment and prescription of aerobic training in these equipments are still scarce. The objective of this study was to propose an adapted test of Conconi et al (1982 to aquatic bicycle. 27 participants (24 ± 6 years, 171 ± 8 cm, 66 ± 12 kg, 15 male and 12 female, were assessed. The participants have been submitted to a graded test in aquatic bicycle, with initial load of 50 RPM and increments of 3 RPM each minute, until exhaustion. HR was registered during the entire test. For data analysis, descriptive statistics were used as well as Student "t" test for comparison between genders. HRDP was identified in 85% of the subjects. There were not significant differences in HRmax (181 ± 12

  16. Macro-level pedestrian and bicycle crash analysis: Incorporating spatial spillover effects in dual state count models.

    Science.gov (United States)

    Cai, Qing; Lee, Jaeyoung; Eluru, Naveen; Abdel-Aty, Mohamed

    2016-08-01

    This study attempts to explore the viability of dual-state models (i.e., zero-inflated and hurdle models) for traffic analysis zones (TAZs) based pedestrian and bicycle crash frequency analysis. Additionally, spatial spillover effects are explored in the models by employing exogenous variables from neighboring zones. The dual-state models such as zero-inflated negative binomial and hurdle negative binomial models (with and without spatial effects) are compared with the conventional single-state model (i.e., negative binomial). The model comparison for pedestrian and bicycle crashes revealed that the models that considered observed spatial effects perform better than the models that did not consider the observed spatial effects. Across the models with spatial spillover effects, the dual-state models especially zero-inflated negative binomial model offered better performance compared to single-state models. Moreover, the model results clearly highlighted the importance of various traffic, roadway, and sociodemographic characteristics of the TAZ as well as neighboring TAZs on pedestrian and bicycle crash frequency. PMID:27153525

  17. Design and Analysis of a Novel Speed-Changing Wheel Hub with an Integrated Electric Motor for Electric Bicycles

    Directory of Open Access Journals (Sweden)

    Yi-Chang Wu

    2013-01-01

    Full Text Available The aim of this paper is to present an innovative electromechanical device which integrates a brushless DC (BLDC hub motor with a speed-changing wheel hub stored on the rear wheel of an electric bicycle. It combines a power source and a speed-changing mechanism to simultaneously provide functions of power generation and transmission for electric bicycles. As part of the proposed integrated device, the wheel hub consists of a basic planetary gear train providing three forward speeds including a low-speed gear, a direct drive, and a high-speed gear. Each gear is manually controlled by the shift control sleeve to selectively engage or disengage four pawl-and-ratchet clutches based on its clutching sequence table. The number of gear teeth of each gear element of the wheel hub is synthesized. The BLDC hub motor is an exterior-rotor-type permanent-magnet synchronous motor. Two-dimensional finite-element analysis (FEA software is employed to facilitate the motor design and performance analysis. An analysis of the power transmission path at each gear is provided to verify the validity of the proposed design. The results of this work are beneficial to the embodiment, design, and development of novel electromechanical devices for the power and transmission systems of electric bicycles.

  18. Design of "N-bike" folding bicycle%N-bike折叠自行车的设计研究

    Institute of Scientific and Technical Information of China (English)

    刘自范; 陈艳红; 张鬲君; 田华泉

    2012-01-01

    In order to make the folding bike be ride comfortably and be carried easily,the stress a-nalysis and optimization design for frame,chain box and other major components were made. The "N-bike" bicycle had been folded easily in five times, then the volume became 0.03 m3 and the weight was 5. 4 kg. The bicycle frame was "N" font shape and according to the principle of ergonomics, its layout was reasonable. The riding position of the bicycle becomes more comfortable. With more labor-saving transmission, strong practicability, dynamic and stylish appearance, the N-bike is more suitable as a convenient means of transport for cities.%为了使折叠自行车既骑行舒适又易携带,对车架、链盒等主要部件进行受力分析及优化设计.设计出的N-bike自行车,经过5次完成折叠,体积为0.03 m3,质量为5.4 kg,车架为“N”字型形状,根据人机工程学原理设计,布局合理.N-bike骑行更舒适,传动更省力,实用性强,外形动感时尚,更适合作为城市便捷的代步工具.

  19. Bicycle and Car Share Schemes as Inclusive Modes of Travel? A Socio-Spatial Analysis in Glasgow, UK

    Directory of Open Access Journals (Sweden)

    Julie Clark

    2016-06-01

    Full Text Available Public bicycle and car sharing schemes have proliferated in recent years and are increasingly part of the urban transport landscape. Shared transport options have the potential to support social inclusion by improving accessibility: these initiatives could remove some of the barriers to car ownership or bicycle usage such as upfront costs, maintenance and storage. However, the existing evidence base indicates that, in reality, users are most likely to be white, male and middle class. This paper argues that there is a need to consider the social inclusivity of sharing schemes and to develop appropriate evaluation frameworks accordingly. We therefore open by considering ways in which shared transport schemes might be inclusive or not, using a framework developed from accessibility planning. In the second part of the paper, we use the case study of Glasgow in Scotland to undertake a spatial equity analysis of such schemes. We examine how well they serve different population groups across the city, using the locations of bicycle stations and car club parking spaces in Glasgow, comparing and contrasting bike and car. An apparent failure to deliver benefits across the demographic spectrum raises important questions about the socially inclusive nature of public investment in similar schemes.

  20. Adult headform impact tests of three Japanese child bicycle helmets into a vehicle.

    Science.gov (United States)

    Mizuno, Koji; Ito, Daisuke; Yoshida, Ryoichi; Masuda, Hiroyuki; Okada, Hiroshi; Nomura, Mitsunori; Fujii, Chikayo

    2014-12-01

    The head is the body region that most frequently incurs fatal and serious injuries of cyclists in collisions against vehicles. Many research studies investigated helmet effectiveness in preventing head injuries using accident data. In this study, the impact attenuation characteristics of three Japanese child bicycle helmets were examined experimentally in impact tests into a concrete surface and a vehicle. A pedestrian adult headform with and without a Japanese child bicycle helmet was dropped onto a concrete surface and then propelled into a vehicle at 35 km/h in various locations such as the bonnet, roof header, windshield and A-pillar. Accelerations were measured and head injury criterion (HIC) calculated. In the drop tests using the adult headform onto a concrete surface from the height of 1.5m, the HIC for a headform without a child helmet was 6325, and was reduced by around 80% when a child helmet was fitted to the headform. In the impact tests, where the headform was fired into the vehicle at 35 km/h at various locations on a car, the computed acceleration based HIC varied depending on the vehicle impact locations. The HIC was reduced by 10-38% for impacts headforms with a child helmet when the impact was onto a bonnet-top and roof header although the HIC was already less than 1000 in impacts with the headform without a child helmet. Similarly, for impacts into the windshield (where a cyclist's head is most frequently impacted), the HIC using the adult headform without a child helmet was 122; whereas when the adult headform was used with a child helmet, a higher HIC value of more than 850 was recorded. But again, the HIC values are below 1000. In impacts into the A-pillar, the HIC was 4816 for a headform without a child helmet and was reduced by 18-38% for a headform with a child helmet depending on the type of Japanese child helmet used. The tests demonstrated that Japanese child helmets are effective in reducing accelerations and HIC in a drop test using

  1. Adult headform impact tests of three Japanese child bicycle helmets into a vehicle.

    Science.gov (United States)

    Mizuno, Koji; Ito, Daisuke; Yoshida, Ryoichi; Masuda, Hiroyuki; Okada, Hiroshi; Nomura, Mitsunori; Fujii, Chikayo

    2014-12-01

    The head is the body region that most frequently incurs fatal and serious injuries of cyclists in collisions against vehicles. Many research studies investigated helmet effectiveness in preventing head injuries using accident data. In this study, the impact attenuation characteristics of three Japanese child bicycle helmets were examined experimentally in impact tests into a concrete surface and a vehicle. A pedestrian adult headform with and without a Japanese child bicycle helmet was dropped onto a concrete surface and then propelled into a vehicle at 35 km/h in various locations such as the bonnet, roof header, windshield and A-pillar. Accelerations were measured and head injury criterion (HIC) calculated. In the drop tests using the adult headform onto a concrete surface from the height of 1.5m, the HIC for a headform without a child helmet was 6325, and was reduced by around 80% when a child helmet was fitted to the headform. In the impact tests, where the headform was fired into the vehicle at 35 km/h at various locations on a car, the computed acceleration based HIC varied depending on the vehicle impact locations. The HIC was reduced by 10-38% for impacts headforms with a child helmet when the impact was onto a bonnet-top and roof header although the HIC was already less than 1000 in impacts with the headform without a child helmet. Similarly, for impacts into the windshield (where a cyclist's head is most frequently impacted), the HIC using the adult headform without a child helmet was 122; whereas when the adult headform was used with a child helmet, a higher HIC value of more than 850 was recorded. But again, the HIC values are below 1000. In impacts into the A-pillar, the HIC was 4816 for a headform without a child helmet and was reduced by 18-38% for a headform with a child helmet depending on the type of Japanese child helmet used. The tests demonstrated that Japanese child helmets are effective in reducing accelerations and HIC in a drop test using

  2. Bicycle-spoke injuries of the foot and ankle: A prospective study

    Directory of Open Access Journals (Sweden)

    HK Gupta

    2014-04-01

    Full Text Available Objective Bicycle spoke wheel injuries can be as simple as minor abrasions and lacerations even to amputation of toes and heel injuries. The purpose of this study was to assess the severity of soft tissue damage and skeletal injuries in such injuries. Methods This prospective observational study included all the cases with spoke wheel injuries presenting between October 2012 to September 2013 in the College of Medical Sciences and Teaching Hospital, Bharatpur. Demographic information was collected from each patient including age, sex, injured side, position at the time of injury, and characteristic of injury. The soft tissue injury was classified according to Oestern and Tscherne classification and managed accordingly. Results A total of 50 cases were included in the study with 29 males ( 58% and 21 females (42% . Their age ranged from 6 yrs to 12 yrs (mean 9 yrs.. The mean interval from injury to presentation in hospital was 5 hrs (range 1-22 hrs. Majority had injury to right ankle and foot. Fore foot and mid foot injuries were more common when the feet got entrapped in front wheel. 36 cases had sustained injury while riding as pillion on the back seat and their injury was on posterior ankle (n=20 and posterolateral aspect of ankle and foot (n=16. Majority of cases were of grade 0 and 1 injury. Two patients had grade 3 injury, one with great toe amputation another with partial heel avulsion and exposed tendoachilles. All cases were managed with wound care, tetanus prophylaxis and splintage of the foot. Conclusion In our study we found that these spoke wheel related injuries were more common in children and are important cause of temporary loss of daily activities. Although all injuries healed properly, risk of severe injuries like amputations and heel pad loss and tendoachilles transaction and fractures of foot and ankle still prevails where bicycle is a common mode of transportation. Journal of College of Medical Sciences-Nepal, 2013, Vol-9

  3. Users, uses and potential of electric-assisted bicycles - Results of a survey in the Canton of Geneva; Usagers, usages et potentiel des velos a assistance electrique. Resultats d'une enquete menee dans le canton de Geneve

    Energy Technology Data Exchange (ETDEWEB)

    Bernardoni, S.; Iseli, A.; Munafo, S.

    2009-12-15

    The municipal, regional and national authorities wanted to assess the potential of electric-assisted bicycles in the Geneva region. A survey performed by the University of Geneva is reported. The following points were investigated: (i) Who uses an electric bicycle? (ii) How is an electric bicycle used? (iii) Why is an electric bicycle purchased? (iv) How many people could potentially use an electric bicycle in the Geneva region? (v) How much energy would be saved and what fraction of the carbon dioxide emissions would be avoided thanks to electric bicycles in the region? Some interesting results: Most current electric bicycle users are women and live in Geneva outskirts. Most users have an academic degree or equivalent and have a good job. Most of them have also a car and other bicycles without electric motor. The main uses of electric bicycles is commuting between house and job locations, leisure activities and shopping. The average annual distance per electric bicycle is about 3000 km. The majority of the electric bicycles in use are limited to 25 km/h and can be driven without any license. The users wish an extension of the bicycle track network along the roads and of the protected parking areas. The number of potential users in the City of Geneva is estimated to 9% or 15,600 new users and to 10% or 43,000 new users in the suburbs. In 2030, 7,500,000 litres-equivalent of gasoline could be annually saved in the region and more than 16,000 tons CO{sub 2} emissions avoided.

  4. From bicycle chain ring shape to gear ratio: algorithm and examples.

    Science.gov (United States)

    van Soest, A J

    2014-01-01

    A simple model of the bicycle drive system with a non-circular front chain ring is proposed and an algorithm is devised for calculation of the corresponding Gear Ratio As a Function Of Crank Angle (GRAFOCA). It is shown that the true effective radius of the chain ring is always the perpendicular distance between the crank axis and the line through the chain segment between the chain ring and the cog. It is illustrated that the true effective radius of the chain ring at any crank angle may differ substantially from the maximum vertical distance between the crank axis and the chain ring circumference that is used as a proxy for the effective chain ring radius in several studies; in particular, the crank angle at which the effective chain ring radius is maximal as predicted from the latter approach may deviate by as much as 0.30 rad from the true value. The algorithm proposed may help in designing chain rings that achieve the desired GRAFOCA. PMID:24200338

  5. Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase.

    Science.gov (United States)

    Pinto, Andrea; Tamborini, Lucia; Pennacchietti, Eugenia; Coluccia, Antonio; Silvestri, Romano; Cullia, Gregorio; De Micheli, Carlo; Conti, Paola; De Biase, Daniela

    2016-01-01

    The γ-aminobutyrate (GABA)-degradative enzyme GABA aminotransferase (GABA-AT) is regarded as an attractive target to control GABA levels in the central nervous system: this has important implications in the treatment of several neurological disorders and drug dependencies. We have investigated the ability of newly synthesized compounds to act as GABA-AT inhibitors. These compounds have a unique bicyclic structure: the carbocyclic ring bears the GABA skeleton, while the fused 3-Br-isoxazoline ring contains an electrophilic warhead susceptible of nucleophilic attack by an active site residue of the target enzyme. Out of the four compounds tested, only the one named (+)-3 was found to significantly inhibit mammalian GABA-AT in vitro. Docking studies, performed on the available structures of GABA-AT, support the experimental findings: out of the four tested compounds, only (+)-3 suitably orients the electrophilic 3-Br-isoxazoline warhead towards the active site nucleophilic residue Lys329, thereby explaining the irreversible inhibition of GABA-AT observed experimentally. PMID:25807299

  6. An Ultra-Low Power Wireless Sensor Network for Bicycle Torque Performance Measurements

    Directory of Open Access Journals (Sweden)

    Sadik K. Gharghan

    2015-05-01

    Full Text Available In this paper, we propose an energy-efficient transmission technique known as the sleep/wake algorithm for a bicycle torque sensor node. This paper aims to highlight the trade-off between energy efficiency and the communication range between the cyclist and coach. Two experiments were conducted. The first experiment utilised the Zigbee protocol (XBee S2, and the second experiment used the Advanced and Adaptive Network Technology (ANT protocol based on the Nordic nRF24L01 radio transceiver chip. The current consumption of ANT was measured, simulated and compared with a torque sensor node that uses the XBee S2 protocol. In addition, an analytical model was derived to correlate the sensor node average current consumption with a crank arm cadence. The sensor node achieved 98% power savings for ANT relative to ZigBee when they were compared alone, and the power savings amounted to 30% when all components of the sensor node are considered. The achievable communication range was 65 and 50 m for ZigBee and ANT, respectively, during measurement on an outdoor cycling track (i.e., velodrome. The conclusions indicate that the ANT protocol is more suitable for use in a torque sensor node when power consumption is a crucial demand, whereas the ZigBee protocol is more convenient in ensuring data communication between cyclist and coach.

  7. A Survey on Energy Efficient Wireless Sensor Networks for Bicycle Performance Monitoring Application

    Directory of Open Access Journals (Sweden)

    Sadik Kamel Gharghan

    2014-01-01

    Full Text Available Wireless sensor networks (WSNs have greatly advanced in the past few decades and are now widely used, especially for remote monitoring; the list of potential uses seems endless. Three types of wireless sensor technologies (Bluetooth, ZigBee, and ANT have been used to monitor the biomechanical and physiological activities of bicycles and cyclists, respectively. However, the wireless monitoring of these activities has faced some challenges. The aim of this paper is to highlight various methodologies for monitoring cycling to provide an effective and efficient way to overcome the various challenges and limitations of sports cycling using wireless sensor interfaces. Several design criteria were reviewed and compared with different solutions for the implementation of current WSN research, such as low power consumption, long distance communications, small size, and light weight. Conclusions were drawn after observing the example of an advanced and adaptive network technology (ANT network highlighting reduced power consumption and prolonged battery life. The power saving achieved in the slave node was 88–95% compared to the similar ANT protocol used in the medical rehabilitation.

  8. THE EFFECTS OF BICYCLE FRAME GEOMETRY ON MUSCLE ACTIVATION AND POWER DURING A WINGATE ANAEROBIC TEST

    Directory of Open Access Journals (Sweden)

    Mark D. Ricard

    2006-03-01

    Full Text Available The purpose of this study was to compare the effects of bicycle seat tube angles (STA of (72° and 82° on power production and EMG of the vastus laeralis (VL, vastus medialis (VM, semimembranous (SM, biceps femoris (BF during a Wingate test (WAT. Twelve experienced cyclists performed a WAT at each STA. Repeated measures ANOVA was used to identify differences in muscular activation by STA. EMG variables were normalized to isometric maximum voluntary contraction (MVC. Paired t-tests were used to test the effects of STA on: peak power, average power, minimum power and percent power drop. Results indicated BF activation was significantly lower at STA 82° (482.9 ± 166.6 %MVC·s compared to STA 72° (712.6 ± 265.6 %MVC·s. There were no differences in the power variables between STAs. The primary finding was that increasing the STA from 72° to 82° enabled triathletes' to maintain power production, while significantly reducing the muscular activation of the biceps femoris muscle

  9. The protective effect of a helmet in three bicycle accidents--A finite element study.

    Science.gov (United States)

    Fahlstedt, Madelen; Halldin, Peter; Kleiven, Svein

    2016-06-01

    There is some controversy regarding the effectiveness of helmets in preventing head injuries among cyclists. Epidemiological, experimental and computer simulation studies have suggested that helmets do indeed have a protective effect, whereas other studies based on epidemiological data have argued that there is no evidence that the helmet protects the brain. The objective of this study was to evaluate the protective effect of a helmet in single bicycle accident reconstructions using detailed finite element simulations. Strain in the brain tissue, which is associated with brain injuries, was reduced by up to 43% for the accident cases studied when a helmet was included. This resulted in a reduction of the risk of concussion of up to 54%. The stress to the skull bone went from fracture level of 80 MPa down to 13-16 MPa when a helmet was included and the skull fracture risk was reduced by up to 98% based on linear acceleration. Even with a 10% increased riding velocity for the helmeted impacts, to take into account possible increased risk taking, the risk of concussion was still reduced by up to 46% when compared with the unhelmeted impacts with original velocity. The results of this study show that the brain injury risk and risk of skull fracture could have been reduced in these three cases if a helmet had been worn. PMID:26974030

  10. Isolated Jejunal Perforation Following Bicycle Handlebar Injury in Adults: A Case Report

    Science.gov (United States)

    Neofytou, Kyriakos; Michailidou, Maria; Petrou, Athanasios; Loizou, Sakis; Andreou, Charalampos

    2013-01-01

    The small intestine is the third in frequency intraperitoneal organ which is injured after blunt trauma of the abdomen. In most of the cases, this type of injuries is accompanied by other injuries, which make it more difficult to diagnose. Failure of diagnosis and delay in treating these injuries significantly increase the morbidity and mortality of these patients. Abdominal visceral injuries after flipping the handlebar of the bike are common in children. Such injuries can cause injury to both solid and hollow abdominal viscera. Unlike children, adults' abdominal visceral injuries after flipping the bike's handlebar are extremely rare. A 25-year-old man was admitted to our department due to progressively abdominal pain after an accident with the handlebar of his bike. The subsequent CT scan after per os administration of contrast medium revealed the presence of free intraperitoneal contrast. It is a rare case of jejunal perforation after flipping the handlebar of the bicycle which was treated by partial removal of the injured part of jejunum and end-to-end anastomosis. To the best of our knowledge this is the first time we describe such an injury with this mechanism to an adult. PMID:23984116

  11. Relationship between the Pedaling Biomechanics and Strain of Bicycle Frame during Submaximal Tests

    Directory of Open Access Journals (Sweden)

    Aneliya V. Manolova

    2015-06-01

    Full Text Available The aim of this study was to analyse the effect of forces applied to pedals and cranks on the strain imposed to an instrumented bicycle motocross (BMX frame. Using results from a finite element analysis to determine the localisation of highest stress, eight strain gauges were located on the down tube, the seat tube and the right chain stay. Before the pedaling tests, static loads were applied to the frame during bench tests. Two pedaling conditions have been analysed. In the first, the rider was in static standing position on the pedals and applied maximal muscular isometric force to the right pedal. The second pedaling condition corresponds to three pedaling sprint tests at submaximal intensities at 150, 300 and 550 W on a cycle-trainer. The results showed that smaller strain was observed in the pedaling condition than in the rider static standing position condition. The highest strains were located in the seat tube and the right chain stay near the bottom bracket area. The maximum stress observed through all conditions was 41 MPa on the right chain stay. This stress was 11 times lower than the yield stress of the frame material (460 MPa. This protocol could help to adapt the frame design to the riders as a function of their force and mechanical power output. These results could also help design BMX frames for specific populations (females and rider morphology.

  12. Fatal transorbital penetrating intracranial injury caused by a bicycle hand brake

    Science.gov (United States)

    2012-01-01

    A transorbital penetrating intracranial injury is a rare and severe traumatic brain injury. Patients with this type of injury may present dramatically, but often the injury is subtle and therefore easily overlooked and not recognized in the first place. We present the case of a 45-year-old female admitted to the emergency department after she fell with her bike and the bicycle brake handle penetrated her left eye. A computerized tomography of the cerebrum showed a fracture of the superior orbital roof with multiple bone fragments extending into the brain near the circle of Willis. A pneumocephalus and traumatic frontobasal, intraventricular and subdural hemorrhage was seen. The patient deteriorated suddenly and was transferred to a neurosurgical center where she underwent an emergency craniotomy with evacuation of the intracerebral hematoma and an intraventricular drain was placed. After surgery, the patient’s condition deteriorated, and total compression of the brain stem occurred, upon which the patient was declared brain dead. Our case report shows that the Glasgow Coma Scale score at admission is not always a good predictor of the severity of the injury. Even when there is minimal suspicion of a penetrating intracranial injury, a computerized tomography should be performed immediately, independent of the patient’s Glasgow Coma Scale score. A direct transfer to a specialized neurosurgical center is recommended because this injury often results in death due to fatal complications such as intracerebral hemorrhage, pneumocephalus and brain stem injury. PMID:22989177

  13. State and actuator fault estimation observer design integrated in a riderless bicycle stabilization system.

    Science.gov (United States)

    Brizuela Mendoza, Jorge Aurelio; Astorga Zaragoza, Carlos Manuel; Zavala Río, Arturo; Pattalochi, Leo; Canales Abarca, Francisco

    2016-03-01

    This paper deals with an observer design for Linear Parameter Varying (LPV) systems with high-order time-varying parameter dependency. The proposed design, considered as the main contribution of this paper, corresponds to an observer for the estimation of the actuator fault and the system state, considering measurement noise at the system outputs. The observer gains are computed by considering the extension of linear systems theory to polynomial LPV systems, in such a way that the observer reaches the characteristics of LPV systems. As a result, the actuator fault estimation is ready to be used in a Fault Tolerant Control scheme, where the estimated state with reduced noise should be used to generate the control law. The effectiveness of the proposed methodology has been tested using a riderless bicycle model with dependency on the translational velocity v, where the control objective corresponds to the system stabilization towards the upright position despite the variation of v along the closed-loop system trajectories. PMID:26708303

  14. The Path of the Bicycle. Reflections on the Sense, Achievements and Challenges of the Iberoamerican Summits

    Directory of Open Access Journals (Sweden)

    Manuel Montobbio

    2000-12-01

    Full Text Available In responding to the question of the meaning and the sense of the Iberoamerican Summits in the international community of the post-cold war period, their achievements and future challenges with particular attention to their implications for Spanish foreign policy, the author undertakes an intellectual itinerary whose point of departure is a consideration of the players and reasons at the origin of the Summits with particular attention to the “driving” foreign policies of Spain—in the context of its “external transition” and Mexico.He then moves on to look at the different collective subjects whose construction is variously proposed: the Iberoamerican Summits as such, the Iberoamerican Community of Nations or the Iberoamerican region. He analyzes the functioning and the dynamics of the processthus far and its achievements and then inquires into possible directions an evolution might take in a forum that must be understood as a process. He also looks into its strategic position in the complex architecture-under-construction of the international, bilateral and multilateral insertion of Latin America, a process put into motion from the top that has moved along like a bicycle requiring constant pedaling so as not to fall over and that faces the challenge of catching on further down and consolidating itself in its own dynamic that does not rely only on the initial pedaling.

  15. Gamow's bicycle: The Appearance of Bodies at Relativistic Speeds and Apparent Superluminal Velocities

    CERN Document Server

    Nowojewski, A

    2005-01-01

    A human creates an image basing on the information delivered by photons that arrived at his retina simultaneously. Due to finite and constant velocity of light these photons left the moving body at different times, since not all points of the body are equidistant. In other words its image represents the body as it was in several different times i.e. it is distorted and does not correspond to its real appearance. The useful experimental arrangement is set and then used to derive the general expression that transforms two-dimensional stationary shapes to their apparent forms, which could be photographed once they are set in motion. It is then used to simulate the so-called Gamow's bicycle combined out of circles and straight lines. The simulation outlines two important aspects of bike's motion: apparent distance of two points and apparent velocity which are then discussed thoroughly. It is found that the approaching body is elongated and its apparent speed is greater than its real one (under certain conditions ...

  16. Two Pilot Studies of the Effect of Bicycling on Balance and Leg Strength among Older Adults

    Directory of Open Access Journals (Sweden)

    Chris Rissel

    2013-01-01

    Full Text Available Objectives. Study 1 examines whether age-related declines in balance are moderated by bicycling. Study 2 tests whether regular cycling can increase leg strength and improve balance. Methods. Study 1: a cross-sectional survey of 43 adults aged 44–79 was conducted. Leg strength was measured, and Balance was measured using the choice stepping reaction time (CSRT test (decision time and response time, leg strength and timed single leg standing. Study 2: 18 older adults aged 49–72 were recruited into a 12-week cycling program. The same pre- and postmeasures as used in Study 1 were collected. Results. Study 1: participants who had cycled in the last month performed significantly better on measures of decision time and response time. Study 2: cycling at least one hour a week was associated with significant improvements in balance (decision time and response time and timed single leg standing. Conclusions. Cycling by healthy older adults appears promising for improving risk factors for falls.

  17. Isolated Jejunal Perforation Following Bicycle Handlebar Injury in Adults: A Case Report

    Directory of Open Access Journals (Sweden)

    Kyriakos Neofytou

    2013-01-01

    Full Text Available The small intestine is the third in frequency intraperitoneal organ which is injured after blunt trauma of the abdomen. In most of the cases, this type of injuries is accompanied by other injuries, which make it more difficult to diagnose. Failure of diagnosis and delay in treating these injuries significantly increase the morbidity and mortality of these patients. Abdominal visceral injuries after flipping the handlebar of the bike are common in children. Such injuries can cause injury to both solid and hollow abdominal viscera. Unlike children, adults’ abdominal visceral injuries after flipping the bike’s handlebar are extremely rare. A 25-year-old man was admitted to our department due to progressively abdominal pain after an accident with the handlebar of his bike. The subsequent CT scan after per os administration of contrast medium revealed the presence of free intraperitoneal contrast. It is a rare case of jejunal perforation after flipping the handlebar of the bicycle which was treated by partial removal of the injured part of jejunum and end-to-end anastomosis. To the best of our knowledge this is the first time we describe such an injury with this mechanism to an adult.

  18. Isolated jejunal perforation following bicycle handlebar injury in adults: a case report.

    Science.gov (United States)

    Neofytou, Kyriakos; Michailidou, Maria; Petrou, Athanasios; Loizou, Sakis; Andreou, Charalampos; Pedonomou, Marios

    2013-01-01

    The small intestine is the third in frequency intraperitoneal organ which is injured after blunt trauma of the abdomen. In most of the cases, this type of injuries is accompanied by other injuries, which make it more difficult to diagnose. Failure of diagnosis and delay in treating these injuries significantly increase the morbidity and mortality of these patients. Abdominal visceral injuries after flipping the handlebar of the bike are common in children. Such injuries can cause injury to both solid and hollow abdominal viscera. Unlike children, adults' abdominal visceral injuries after flipping the bike's handlebar are extremely rare. A 25-year-old man was admitted to our department due to progressively abdominal pain after an accident with the handlebar of his bike. The subsequent CT scan after per os administration of contrast medium revealed the presence of free intraperitoneal contrast. It is a rare case of jejunal perforation after flipping the handlebar of the bicycle which was treated by partial removal of the injured part of jejunum and end-to-end anastomosis. To the best of our knowledge this is the first time we describe such an injury with this mechanism to an adult.

  19. Study of piezoelectric materials combined with electromagnetic design for bicycle harvesting system

    Directory of Open Access Journals (Sweden)

    Dyi-Cheng Chen

    2016-04-01

    Full Text Available Energy harvesting device involves capturing energy from the environment and it is increasingly crucial in the crisis of greenhouse effect nowadays. Equipping bicycles with many types of shock absorbers can enhance the riding comfort. Additionally, an embedded energy harvesting device will gain much benefit beyond the sports. This study applied the finite element method to analyze the components of nonlinear magnetic spring. The analytical simulations were conducted to analyze the electromagnetic effect in ANSYS©/Emag software. A model equipped with nonlinear magnetic springs was constructed to absorb the impact energy. Nevertheless, the piezoelectric components were used to capture the piezoelectric effect current caused by the compressive stress. A series of simulations were conducted, such as changing the diameter of the magnet, electric coil width, and the position of the coils. Moreover, with those finite element analysis data, the Taguchi method L9(34 orthogonal arrays were applied to determine the optimal parametric dimensions of the electromagnetic and piezoelectric assemblies for maximizing the captured kinetic energy and power transformation. The results could assist the suspension manufacturers to innovate their design for energy harvesting and impact absorbing.

  20. An ultra-low power wireless sensor network for bicycle torque performance measurements.

    Science.gov (United States)

    Gharghan, Sadik K; Nordin, Rosdiadee; Ismail, Mahamod

    2015-01-01

    In this paper, we propose an energy-efficient transmission technique known as the sleep/wake algorithm for a bicycle torque sensor node. This paper aims to highlight the trade-off between energy efficiency and the communication range between the cyclist and coach. Two experiments were conducted. The first experiment utilised the Zigbee protocol (XBee S2), and the second experiment used the Advanced and Adaptive Network Technology (ANT) protocol based on the Nordic nRF24L01 radio transceiver chip. The current consumption of ANT was measured, simulated and compared with a torque sensor node that uses the XBee S2 protocol. In addition, an analytical model was derived to correlate the sensor node average current consumption with a crank arm cadence. The sensor node achieved 98% power savings for ANT relative to ZigBee when they were compared alone, and the power savings amounted to 30% when all components of the sensor node are considered. The achievable communication range was 65 and 50 m for ZigBee and ANT, respectively, during measurement on an outdoor cycling track (i.e., velodrome). The conclusions indicate that the ANT protocol is more suitable for use in a torque sensor node when power consumption is a crucial demand, whereas the ZigBee protocol is more convenient in ensuring data communication between cyclist and coach. PMID:26007728

  1. 7500 km journey with their solar-powered bicycles: show your solidarity with their efforts

    CERN Multimedia

    Staff Association

    2013-01-01

    Our colleagues, Céline and Jean, are currently on a 7500 km journey from Geneva to Astana (Kazakhstan) via Sotchi (in Russia, mandatory stopover) to promote ecology with their solar-powered bicycles. In the context of their trip, they asked the Staff Association to launch an action of solidarity in the framework of the Long-Term Collections. It is with pleasure that we have accepted their proposal and that we offer you the possibility to take part in this humanitarian initiative. You can participate by pledging to donate CHF 10 for each country that will be crossed by Céline and Jean, which corresponds to a maximum commitment of 100 CHF. Indeed, their scheduled trip will include 10 countries across Europe and Asia. Today they are in Hungary, after travelling through parts of Switzerland, France, Italy, Slovenia and Croatia.  The details on how to participate will be published in our next issue of Echo.   For further information about this wonderful adventure, pl...

  2. [Study on Strain Detection with Si Based on Bicyclic Cascade Optical Microring Resonator].

    Science.gov (United States)

    Tang, Jun; Lei, Long-hai; Zhang, Wei; Zhang, Tian-en; Xue, Chen-yang; Zhang, Wen-dong; Liu, Jun

    2016-03-01

    Optical micro-ring resonator prepared on Silicon-On-Insulator (SOI) has high sensitivity, small size and low mode volume. Its high sensitivity has been widely applied to the optical information transmission and inertial navigation devices field, while it is rarely applied in the testing of Mechanics. This paper presents a cantilever stress/strain gauge with an optical microring resonator. It is proposed the using of radius change of ring waveguide for the sensing element. When external stress is put on the structure, the radius of the SOI ring waveguide will be subjected to variation, which causes the optical resonant parameters to change. This ultimately leads to a red-shift of resonant spectrum, and shows the excellent characteristics of the structure's stress/strain sensitivity. Designed a bicyclic cascade embedded optical micro-cavity structure, which was prepared by employing MEMS lithography and ICP etching process. The characteristic of stress/strain sensitivity was calculated theoretically. Two values of 0.185 pm x kPa(-1) and 18.04 pm x microstrain(-1) were obtained experimentally, which also was verified by theoretical simulations. Comparing with the single-loop micro-cavity structure, its measuring range and stress sensitivity increased by nearly 50.3%, 10.6%, respectively. This paper provides a new method to develop micro-opto-electromechanical system (MOEMS) sensors. PMID:27400541

  3. PROMOTION EFFECT OF MELAMINE ON FLAME RETARDANCY OF EPOXY RESINS CONTAINING CAGED BICYCLIC PHOSPHATE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Caged bicyclic phosphate (CBP) and its dimelamine salt (PDS) were synthesized and added to epoxy resins to obtain the flame retarded epoxy resin composites. The flammability of the composites was characterized by the limiting oxygen index (LOI) and cone calorimeter tests. The LOI values of flame retarded composites increase consistently with the increase of flame retardant amounts, and they are almost the same when the loading of CBP is the same as that of PDS,although the phosphorus content of PDS is much lower than that of CBP. The total heat release increases in the order of CBP30/ER < PDS30/ER < PDS15/ER < CBP15/ER, whereas that of specific extinction area is CBP15/ER > CBP30/ER > PDS30/ER ≌ PDS15/ER. PDS exhibits more effective inhibition of oxidation of combustible gases. In the tests of thermogravimetric analyses (TG) and Fourier transform infrared spectroscopy (FT-IR), it is found that the degradation of the composites is influenced greatly by the addition of flame retardants. By scanning electron microscopy (SEM), a thick and tight char-layer is observed for PDS30/ER, resulting from the interaction of nitrogen species with phosphorus species.Therefore, the combination of CBP with melamine in the flame retarded system can improve the flame retardancy greatly.

  4. 杭州市公共自行车系统服务站点研究%Hangzhou public bicycle system service site study

    Institute of Scientific and Technical Information of China (English)

    程益丹; 张生瑞

    2014-01-01

    为探索如何建设更便民的公共自行车系统和提供更完善的服务,从而提升城市的生活品质,对杭州市公共自行车系统服务站点进行研究。首先,对杭州市的公共自行车交通系统的典型服务站点的运营情况进行研究;然后,总结杭州公共自行车典型点的运行特点;最后,针对杭州市公共自行车交通系统有关服务站点提出几点建议。%For exploring how to construct a public bicycle system more convenient and provide more per-fect service,in order to improve the quality of life in the city,research on the public bicycle service station in Hangzhou city. First, study on operation situation of typical public bicycle service station in Hangzhou city. Then, summarizes its typical stations’ characteristics. Finally, according to Hangzhou public bicy-cle system, put forward several suggestions in public bicycle service station.

  5. Long term bicycle related head injury trends for New South Wales, Australia following mandatory helmet legislation.

    Science.gov (United States)

    Olivier, Jake; Walter, Scott R; Grzebieta, Raphael H

    2013-01-01

    Since the 1991 enactment of mandatory helmet legislation (MHL) for cyclists in New South Wales (NSW), Australia, there has been extensive debate as to its effect on head injury rates at a population level. Many previous studies have focused on the impact of MHL around the time of enactment, while little has been done to examine the ongoing effects. We aimed to extend prior work by investigating long-term trends in cyclist head and arm injuries over the period 1991-2010. The counts of cyclists hospitalised with head or arm injuries were jointly modelled with log-linear regression. The simultaneous modelling of related injury mechanisms avoids the need for actual exposure data and accounts for the effects of changes in the cycling environment, cycling behaviour and general safety improvements. Models were run separately with population counts, bicycle imports, the average weekday counts of cyclists in Sydney CBD and cycling estimates from survey data as proxy exposures. Overall, arm injuries were higher than head injuries throughout the study period, consistent with previous post-MHL observations. The trends in the two injury groups also significantly diverged, such that the gap between rates increased with time. The results suggest that the initial observed benefit of MHL has been maintained over the ensuing decades. There is a notable additional safety benefit after 2006 that is associated with an increase in cycling infrastructure spending. This implies that the effect of MHL is ongoing and progress in cycling safety in NSW has and will continue to benefit from focusing on broader issues such as increasing cycling infrastructure. PMID:23026203

  6. The role of multilevel factors in geographic differences in bicycle crash risk: a prospective cohort study

    Science.gov (United States)

    2013-01-01

    Background Regular cycling plays an important role in increasing physical activity levels but raises safety concerns for many people. While cyclists bear a higher risk of injury than most other types of road users, the risk differs geographically. Auckland, New Zealand’s largest urban region, has a higher injury risk than the rest of the country. This paper identified underlying factors at individual, neighbourhood and environmental levels and assessed their relative contribution to this risk differential. Methods The Taupo Bicycle Study involved 2590 adult cyclists recruited in 2006 and followed over a median period of 4.6 years through linkage to four national databases. The Auckland participants were compared with others in terms of baseline characteristics, crash outcomes and perceptions about environmental determinants of cycling. Cox regression modelling for repeated events was performed with multivariate adjustments. Results Of the 2554 participants whose addresses could be mapped, 919 (36%) resided in Auckland. The Auckland participants were less likely to be Māori but more likely to be socioeconomically advantaged and reside in an urban area. They were less likely to cycle for commuting and off-road but more likely to cycle in the dark and in a bunch, use a road bike and use lights in the dark. They had a higher risk of on-road crashes (hazard ratio: 1.47; 95% CI: 1.22, 1.76), of which 53% (95% CI: 20%, 72%) was explained by baseline differences, particularly related to cycling off-road, in the dark and in a bunch and residing in urban areas. They were more concerned about traffic volume, speed and drivers’ behaviour. Conclusions The excess crash risk in Auckland was explained by cycling patterns, urban residence and factors associated with the region’s car-dominated transport environment. PMID:24321134

  7. Does a Non-Circular Chainring Improve Performance in the Bicycle Motocross Cycling Start Sprint?

    Science.gov (United States)

    Mateo-March, Manuel; Fernández-Peña, Eneko; Blasco-Lafarga, Cristina; Morente-Sánchez, Jaime; Zabala, Mikel

    2014-01-01

    Maximising power output during the initial acceleration phase of a bicycle motocross (BMX) race increases the chance to lead the group for the rest of the race. The purpose of this study was to investigate the effect of non-circular chainrings (Q-ring) on performance during the initial acceleration phase of a BMX race. Sixteen male cyclists (Spanish National BMX team) performed two counterbalanced and randomized initial sprints (3.95s), using Q- ring vs. circular chainring, on a BMX track. The sample was divided into two different groups according to their performance (Elite; n = 8 vs. Cadet; n = 8). Elite group covered a greater distance using Q-ring (+0.26 m, p = 0.02; D = 0.23), whilst the improvement for the Cadet (+0.04 m) was not significant (p = 0.87; D = -0.02). Also, there was no significant difference in power output for the Elite group, while the Cadet group revealed larger peak power with the circular chainring. Neither lactate level, nor heart rate showed significant differences due to the different chainring used. The non-circular chainring improved the initial acceleration capacity only in the Elite riders. Key Points This work provides novel results demonstrating very significant improvements in the sprint performance of BMX cycling discipline using a non-circular chainring system. This study seeks a practical application from scientific analysis All data are obtained in a real context of high competition using a sample comprised by the National Spanish Team. Some variables influencing performance as subjects’ physical fitness are discussed. Technical equipment approved by International Cycling Union is studied to check its potentially beneficial influence on performance. PMID:24570612

  8. [Effects of breathing high concentrations of oxygen on changes in blood indices during bicycle exercise].

    Science.gov (United States)

    Nagata, A; Yoshida, M; Fuke, T; Miyazato, I; Shiba, K

    1990-01-01

    The purpose of this study is to examine effects of hyperoxic gas mixtures on changes of blood indices during bicycle exercise of human. Oxygen-enriched gases (30% O2) were inspired during the ramp load exercise of 25 watt/min. Changes of blood indices were analyzed with Sequential Multiple Analyzer with the computer (SMAC). The improvement of exercise performance were discussed about relationship between function of hyperoxic gas and physiological mechanism. Three experimental conditions were set as follows (I) 30% O2 +N2 gases balance, (II) air (21% O2), and (III) 30% O2 +2% CO2 +N2 gases balance. Arterial blood were sampled from the radial artery of the forearm in order to analyze following items; 1) pH level, PaO2, PaCO2, and HCO3 of these blood gases, 2) Blood sugar, TG, and F-CH of the blood contents, 3) red blood corpuscle, white blood corpuscle, Hb, and Ht values, 4) LDH, CK, GOT, and GPT of the blood enzymes, 5) TP, ALB, Na, K, Ca and Cl of the electric ions. In the case of inspiring hyperoxic gases, the recovery rate of blood indices increased after this ramp load exercise remarkably, and the whole exercise metabolism were removed from acidosis tendency to alkalosis value of the resting condition significantly. At hyperoxic experimental conditions, the blood sugar and oxygen consumption were much more decreased than these at normal oxygen content one during both states of exercise and recovery times. These data of the blood indices would support strongly to the hypothesis that improvement of oxygen delivery should be depended upon the enhanced performance with the hyperoxic gases. There might be effects of the hyperoxia on the cellular metabolism and on function of the vascular muscle during those aerobic exercise.

  9. Long distance bicycle riding causes prostate-specific antigen to increase in men aged 50 years and over.

    Directory of Open Access Journals (Sweden)

    Sandra L Mejak

    Full Text Available OBJECTIVES: To investigate whether bicycle riding alters total prostate-specific antigen (tPSA serum concentrations in healthy older men. METHODS: 129 male participants, ranging in age from 50 to 71 years (mean 55 years, rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. RESULTS: Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1-12.9; p<0.001 or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges. Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled. CONCLUSIONS: Cycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24-48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results.

  10. Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

    Science.gov (United States)

    Mejak, Sandra L.; Bayliss, Julianne; Hanks, Shayne D.

    2013-01-01

    Objectives To investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men. Methods 129 male participants, ranging in age from 50 to 71 years (mean 55 years), rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. Results Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1–12.9; p<0.001) or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml) increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges). Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled. Conclusions Cycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24–48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results. PMID:23418500

  11. 清华励志修车哥 小人物也有春天%Bicycle Repairman Finds the Right Gear

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    On a chilly day, a man wearing a dirty glove was changing a bicycle chain in front of his repair shop at Tsinghua University. Compared to the surrounding buildings of China's top university, his 3-square-meter shop looks quite small and shabby. But the owner shows his pride, saying, "With my shop, I can repair bicycles for students. Furthermore, with the experience and money I get here, I will manufacture my own bicycles with lower prices but superior quality for them."%从试图结束自己生命的打工者,到成为备受学生尊敬的"修车哥",清华大学修车师傅任玉华在这个校园里追寻着自己的理想,也用自己的故事感动着身边的人。

  12. An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women : Relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise

    NARCIS (Netherlands)

    van der Pompe, G; Bernards, N; Kavelaars, A; Heijnen, C

    2001-01-01

    It is well-established that bicycle exercise alters the endocrine and immune responses in men, but little information is available for women, especially middle-aged, post-menopausal women. The purpose of our study was to document the endocrine and immune reactivity to exhausting bicycle exercise in

  13. Tandem cross enyne metathesis (CEYM)-intramolecular Diels-Alder reaction (IMDAR). An easy entry to linear bicyclic scaffolds.

    Science.gov (United States)

    Miró, Javier; Sánchez-Roselló, María; Sanz, Álvaro; Rabasa, Fernando; Del Pozo, Carlos; Fustero, Santos

    2015-01-01

    A new tandem cross enyne metathesis (CEYM)-intramolecular Diels-Alder reaction (IMDAR) has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enables the preparation of a small family of linear bicyclic scaffolds in a very simple manner with moderate to good levels of diastereoselectivity. This methodology constitutes one of the few examples that employ olefins differently than ethylene in tandem CEYM-IMDAR protocols. PMID:26425205

  14. Robust LQR and LQI control with actuator failure of a 2DOF unmanned bicycle robot stabilized by an inertial wheel

    Directory of Open Access Journals (Sweden)

    Owczarkowski Adam

    2016-06-01

    Full Text Available Essential ingredients for robust control are the ability to cope with different types of system behavior following modeling imperfections and the ability to assure a certain performance level. In this paper, we propose to use an actuator fault-tolerant control law to govern, during experiments, the stabilization of a bicycle robot with an inertial wheel in order to take into account unmodeled uncertainty introduced by using a linearized model in an LQR fashion. Our proposal is illustrated by signal plots and the values of performance indices obtained from a set of experiments.

  15. Challenges in the Accurate Surveillance of Booster Seat and Bicycle Helmet Usage by Children: Lessons from the Field

    Directory of Open Access Journals (Sweden)

    Curt Pankratz

    2016-07-01

    Full Text Available Motor vehicle collisions and bicycle collisions and falls are a leading cause of death by preventable injury for children. In order to design, implement and evaluate campaigns and programs aimed at improving child safety, accurate surveillance is needed. This paper examined the challenges that confront efforts to collect surveillance data relevant to child traffic safety, including observation, interview, and focus group methods. Strategies to address key challenges in order to improve the efficiency and accuracy of surveillance methods were recommended. The potential for new technology to enhance existing surveillance methods was also explored.

  16. Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols.

    Science.gov (United States)

    Painter, Thomas O; Bunn, Jonathon R; Schoenen, Frank J; Douglas, Justin T; Day, Victor W; Santini, Conrad

    2013-04-19

    The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocyclic 3-furanone, are each obtained using a two-step sequence featuring a common first step. Both scaffold types lead to intermediates that can be orthogonally diversified using the same final components. One of the scaffold types was obtained in sufficiently high yield that it was immediately used to produce a 97-compound library.

  17. Challenges in the Accurate Surveillance of Booster Seat and Bicycle Helmet Usage by Children: Lessons from the Field

    Science.gov (United States)

    Pankratz, Curt; Warda, Lynne; Piotrowski, Caroline

    2016-01-01

    Motor vehicle collisions and bicycle collisions and falls are a leading cause of death by preventable injury for children. In order to design, implement and evaluate campaigns and programs aimed at improving child safety, accurate surveillance is needed. This paper examined the challenges that confront efforts to collect surveillance data relevant to child traffic safety, including observation, interview, and focus group methods. Strategies to address key challenges in order to improve the efficiency and accuracy of surveillance methods were recommended. The potential for new technology to enhance existing surveillance methods was also explored. PMID:27399749

  18. Tandem cross enyne metathesis (CEYM–intramolecular Diels–Alder reaction (IMDAR. An easy entry to linear bicyclic scaffolds

    Directory of Open Access Journals (Sweden)

    Javier Miró

    2015-08-01

    Full Text Available A new tandem cross enyne metathesis (CEYM–intramolecular Diels–Alder reaction (IMDAR has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enables the preparation of a small family of linear bicyclic scaffolds in a very simple manner with moderate to good levels of diastereoselectivity. This methodology constitutes one of the few examples that employ olefins differently than ethylene in tandem CEYM–IMDAR protocols.

  19. Challenges in the Accurate Surveillance of Booster Seat and Bicycle Helmet Usage by Children: Lessons from the Field.

    Science.gov (United States)

    Pankratz, Curt; Warda, Lynne; Piotrowski, Caroline

    2016-01-01

    Motor vehicle collisions and bicycle collisions and falls are a leading cause of death by preventable injury for children. In order to design, implement and evaluate campaigns and programs aimed at improving child safety, accurate surveillance is needed. This paper examined the challenges that confront efforts to collect surveillance data relevant to child traffic safety, including observation, interview, and focus group methods. Strategies to address key challenges in order to improve the efficiency and accuracy of surveillance methods were recommended. The potential for new technology to enhance existing surveillance methods was also explored. PMID:27399749

  20. ‘We are the future’: understanding adolescents’ intentions to commute by car or bicycle as adults

    DEFF Research Database (Denmark)

    Sigurdardottir, Sigrun Birna; Kaplan, Sigal; Møller, Mette;

    This study focuses on the intentions of adolescents to commute by car or bicycle as adults, as key elements towards promoting societal transition towards sustainable modes. The behavioral model is based on the theory of planned behavior combined with positive current travel experience, willingness...... passenger experience, general interest in cars, and car-ownership norms, and are negatively related to willingness to accept car restrictions and perceived lack of behavioral control; (ii) cycling intentions are positively related to positive cycling experience, willingness to accept car restrictions...

  1. Comparison of muscle functional electrical stimulation to conventional bicycle exercise on endothelium and functional status indices in patients with heart failure.

    Science.gov (United States)

    Deftereos, Spyridon; Giannopoulos, Georgios; Raisakis, Konstantinos; Kossyvakis, Charalampos; Kaoukis, Andreas; Driva, Metaxia; Pappas, Loukas; Panagopoulou, Vasiliki; Ntzouvara, Olga; Karavidas, Apostolos; Pyrgakis, Vlasios; Rentoukas, Ilias; Aggeli, Constadina; Stefanadis, Christodoulos

    2010-12-01

    The aim of this prospective, open-label, cohort study was to compare the effect of muscle functional electrical stimulation (FES) on endothelial function to that of conventional bicycle training. Eligible patients were those with New York Heart Association class II or III heart failure symptoms and ejection fractions ≤ 0.35. Two physical conditioning programs were delivered: FES of the muscles of the lower limbs and bicycle training, each lasting for 6 weeks, with a 6-week washout period between them. Brachial artery flow-mediated dilation (FMD) and other parameters were assessed before and after FES and the bicycle training program. FES resulted in a significant improvement in FMD, which increased from 5.9 ± 0.5% to 7.7 ± 0.5% (95% confidence interval for the difference 1.5% to 2.3%, p Bicycle training also resulted in a substantial improvement of endothelial function. FMD increased from 6.2 ± 0.4% to 9.2 ± 0.4% (95% confidence interval for the difference 2.5% to 3.5%, p bicycle exercise (95% confidence interval for the difference between the relative changes 1.2% to 30.5%, p = 0.034). This resulted in attaining a significantly higher FMD value after bicycle training compared to FES (9.2 ± 0.4% vs 7.7 ± 0.5%, p < 0.001). In conclusion, the effect of muscle FES in patients with heart failure on endothelial function, although not equivalent to that of conventional exercise, is substantial. Muscle FES protocols may prove very useful in the treatment of patients with heart failure who cannot or will not adhere to conventional exercise programs.

  2. Comparison of muscle functional electrical stimulation to conventional bicycle exercise on endothelium and functional status indices in patients with heart failure.

    Science.gov (United States)

    Deftereos, Spyridon; Giannopoulos, Georgios; Raisakis, Konstantinos; Kossyvakis, Charalampos; Kaoukis, Andreas; Driva, Metaxia; Pappas, Loukas; Panagopoulou, Vasiliki; Ntzouvara, Olga; Karavidas, Apostolos; Pyrgakis, Vlasios; Rentoukas, Ilias; Aggeli, Constadina; Stefanadis, Christodoulos

    2010-12-01

    The aim of this prospective, open-label, cohort study was to compare the effect of muscle functional electrical stimulation (FES) on endothelial function to that of conventional bicycle training. Eligible patients were those with New York Heart Association class II or III heart failure symptoms and ejection fractions ≤ 0.35. Two physical conditioning programs were delivered: FES of the muscles of the lower limbs and bicycle training, each lasting for 6 weeks, with a 6-week washout period between them. Brachial artery flow-mediated dilation (FMD) and other parameters were assessed before and after FES and the bicycle training program. FES resulted in a significant improvement in FMD, which increased from 5.9 ± 0.5% to 7.7 ± 0.5% (95% confidence interval for the difference 1.5% to 2.3%, p Bicycle training also resulted in a substantial improvement of endothelial function. FMD increased from 6.2 ± 0.4% to 9.2 ± 0.4% (95% confidence interval for the difference 2.5% to 3.5%, p bicycle exercise (95% confidence interval for the difference between the relative changes 1.2% to 30.5%, p = 0.034). This resulted in attaining a significantly higher FMD value after bicycle training compared to FES (9.2 ± 0.4% vs 7.7 ± 0.5%, p < 0.001). In conclusion, the effect of muscle FES in patients with heart failure on endothelial function, although not equivalent to that of conventional exercise, is substantial. Muscle FES protocols may prove very useful in the treatment of patients with heart failure who cannot or will not adhere to conventional exercise programs. PMID:21094364

  3. Bicycle Painting Exhaust Gas Treatment Technology Comparison%自行车涂装废气治理技术的对比

    Institute of Scientific and Technical Information of China (English)

    杜万义; 张晓燕

    2015-01-01

    The exhaust gas of bicycle spraying mainly contains two parts. The first part is the mist particles which appear during spraying process. The second part is VOC which appear during the process of spraying and drying. This paper describes the main treatment method of the exhaust gas during bicycle spraying.%自行车涂装废气主要有两部分,一是喷涂过程中产生的漆雾颗粒物,二是喷涂和烘干过程中产生的VOC。本文阐述了涂装废气的治理主要方法。

  4. Energy Efficiency of Ultra-Low-Power Bicycle Wireless Sensor Networks Based on a Combination of Power Reduction Techniques

    Directory of Open Access Journals (Sweden)

    Sadik Kamel Gharghan

    2016-01-01

    Full Text Available In most wireless sensor network (WSN applications, the sensor nodes (SNs are battery powered and the amount of energy consumed by the nodes in the network determines the network lifespan. For future Internet of Things (IoT applications, reducing energy consumption of SNs has become mandatory. In this paper, an ultra-low-power nRF24L01 wireless protocol is considered for a bicycle WSN. The power consumption of the mobile node on the cycle track was modified by combining adjustable data rate, sleep/wake, and transmission power control (TPC based on two algorithms. The first algorithm was a TPC-based distance estimation, which adopted a novel hybrid particle swarm optimization-artificial neural network (PSO-ANN using the received signal strength indicator (RSSI, while the second algorithm was a novel TPC-based accelerometer using inclination angle of the bicycle on the cycle track. Based on the second algorithm, the power consumption of the mobile and master nodes can be improved compared with the first algorithm and constant transmitted power level. In addition, an analytical model is derived to correlate the power consumption and data rate of the mobile node. The results indicate that the power savings based on the two algorithms outperformed the conventional operation (i.e., without power reduction algorithm by 78%.

  5. A Bicycle-Based Field Measurement System for the Study of Thermal Exposure in Cuyahoga County, Ohio, USA.

    Science.gov (United States)

    Rajkovich, Nicholas B; Larsen, Larissa

    2016-02-01

    Collecting a fine scale of microclimate data can help to determine how physical characteristics (e.g., solar radiation, albedo, sky view factor, vegetation) contribute to human exposure to ground and air temperatures. These data also suggest how urban design strategies can reduce the negative impacts of the urban heat island effect. However, urban microclimate measurement poses substantial challenges. For example, data taken at local airports are not representative of the conditions at the neighborhood or district level because of variation in impervious surfaces, vegetation, and waste heat from vehicles and buildings. In addition, fixed weather stations cannot be deployed quickly to capture data from a heat wave. While remote sensing can provide data on land cover and ground surface temperatures, resolution and cost remain significant limitations. This paper describes the design and validation of a mobile measurement bicycle. This bicycle permits movement from space to space within a city to assess the physical and thermal properties of microclimates. The construction of the vehicle builds on investigations of the indoor thermal environment of buildings using thermal comfort carts. PMID:26821037

  6. Bicycle Helmet Wearing Is Not Associated with Close Motor Vehicle Passing: A Re-Analysis of Walker, 2007

    Science.gov (United States)

    Olivier, Jake; Walter, Scott R.

    2013-01-01

    Objectives To re-analyse bicycle overtaking data collected by Walker (2007) with a view to assess factors associated with close passing (<1 m), to adjust for other observed factors in a multivariable analysis, and to assess the extent to which the sample size in the original analysis may have contributed to spurious results. Method A re-analysis of 2,355 motor vehicle passing events recorded by Walker that includes information on cyclist's distance to the kerb, vehicle size and colour, city of observation, time of day, whether the event occurred while in a bikelane and helmet wearing. Each variable was considered for a final, multivariable model using purposeful selection of variables. The analysis was repeated using multiple logistic regression with passing distance dichotomised by the one metre rule. Bootstrap p-values were computed using sample sizes computed from conventional values of power and effect size. Results The previously observed significant association between passing distance and helmet wearing was not found when dichotomised by the one metre rule. Other factors were found to be significantly associated with close passing including cyclists' distance to the kerb, vehicle size and city of observation (Salisbury or Bristol, UK). P-values from bootstrap samples indicate the significance of helmet wearing resulted from an overly large sample size. Conclusions After re-analysis of Walker's data, helmet wearing is not associated with close motor vehicle passing. The results, however, highlight other more important factors that may inform effective bicycle safety strategies. PMID:24086528

  7. Estimating bias from loss to follow-up in a prospective cohort study of bicycle crash injuries

    Science.gov (United States)

    Tin Tin, Sandar; Woodward, Alistair; Ameratunga, Shanthi

    2014-01-01

    Background Loss to follow-up, if related to exposures, confounders and outcomes of interest, may bias association estimates. We estimated the magnitude and direction of such bias in a prospective cohort study of crash injury among cyclists. Methods The Taupo Bicycle Study involved 2590 adult cyclists recruited from New Zealand's largest cycling event in 2006 and followed over a median period of 4.6 years through linkage to four administrative databases. We resurveyed the participants in 2009 and excluded three participants who died prior to the resurvey. We compared baseline characteristics and crash outcomes of the baseline (2006) and follow-up (those who responded in 2009) cohorts by ratios of relative frequencies and estimated potential bias from loss to follow-up on seven exposure-outcome associations of interest by ratios of HRs. Results Of the 2587 cyclists in the baseline cohort, 1526 (60%) responded to the follow-up survey. The responders were older, more educated and more socioeconomically advantaged. They were more experienced cyclists who often rode in a bunch, off-road or in the dark, but were less likely to engage in other risky cycling behaviours. Additionally, they experienced bicycle crashes more frequently during follow-up. The selection bias ranged between −10% and +9% for selected associations. Conclusions Loss to follow-up was differential by demographic, cycling and behavioural risk characteristics as well as crash outcomes, but did not substantially bias association estimates of primary research interest. PMID:24336816

  8. Bicycle helmet wearing is not associated with close motor vehicle passing: a re-analysis of Walker, 2007.

    Directory of Open Access Journals (Sweden)

    Jake Olivier

    Full Text Available OBJECTIVES: To re-analyse bicycle overtaking data collected by Walker (2007 with a view to assess factors associated with close passing (<1 m, to adjust for other observed factors in a multivariable analysis, and to assess the extent to which the sample size in the original analysis may have contributed to spurious results. METHOD: A re-analysis of 2,355 motor vehicle passing events recorded by Walker that includes information on cyclist's distance to the kerb, vehicle size and colour, city of observation, time of day, whether the event occurred while in a bikelane and helmet wearing. Each variable was considered for a final, multivariable model using purposeful selection of variables. The analysis was repeated using multiple logistic regression with passing distance dichotomised by the one metre rule. Bootstrap p-values were computed using sample sizes computed from conventional values of power and effect size. RESULTS: The previously observed significant association between passing distance and helmet wearing was not found when dichotomised by the one metre rule. Other factors were found to be significantly associated with close passing including cyclists' distance to the kerb, vehicle size and city of observation (Salisbury or Bristol, UK. P-values from bootstrap samples indicate the significance of helmet wearing resulted from an overly large sample size. CONCLUSIONS: After re-analysis of Walker's data, helmet wearing is not associated with close motor vehicle passing. The results, however, highlight other more important factors that may inform effective bicycle safety strategies.

  9. The impact of public transportation strikes on use of a bicycle share program in London: interrupted time series design

    Science.gov (United States)

    2013-01-01

    Objective To investigate the immediate and sustained effects of two London Underground strikes on use of a public bicycle share program. Methods An interrupted time series design was used to examine the impact of two 24 hour strikes on the total number of trips per day and mean trip duration per day on the London public bicycle share program. The strikes occurred on September 6th and October 4th 2010 and limited service on the London Underground. Results The mean total number of trips per day over the whole study period was 14699 (SD=5390) while the mean trip duration was 18.5 minutes (SD=3.7). Significant increases in daily trip rate were observed following strike 1 (3864: 95% CI 125 to 7604) and strike 2 (11293: 95% CI 5169 to 17416). Conclusions Brief interventions that greatly constrain the primary motorised mode of transportation for a population may have short-term effects on travel behaviour. Repeated brief interventions at frequent intervals could contribute to increasing population levels of physical activity by promoting the use of active modes of transportation. PMID:22024219

  10. Balanced Motions Realization for a Mechanical Regulators Free and Front-Wheel Drive Bicycle Robot Under Zero Forward Speed

    Directory of Open Access Journals (Sweden)

    Yonghua Huang

    2013-08-01

    Full Text Available This paper focuses on a mechanical regulator free and front‐ wheel drive bicycle robot. We present a scheme to achieve the robotʹs track‐stand motion and circular motion under zero forward speed. In a situation where the robotʹs front‐bar is locked at 90 degrees, a kinetic constraint about the rotating rate of the front‐wheel and the yawing rate of the frame is derived. Using the constraint as a basis, we developed a simplified model of two independent velocities for the robot. The model suggests there is an under‐ actuated rolling angle in the system. Our control strategy originates from the under‐ actuated characteristics of the robot system. Concretely, we linearize the rolling angle of the frame and set the bicycle robot to regulate its tilting by rotating the front‐wheel. In the track‐stand motion, we control the position and the rotational rate of the front‐wheel; but in the circular motion, only the rotational rate of the front‐wheel is strictly regulated. Both simulations and physical experiments results show that our strategy is effective for achieving these two motions.

  11. Effects of static bicycle training on gross motor function, muscle strength and spasticity of adolescents with spastic cerebral palsy

    Directory of Open Access Journals (Sweden)

    CHRISTOS TSIGKANOS

    2013-01-01

    Full Text Available The purpose of the present study was to examine the effects of an 8- week lower limb strengthening program on gross motor function, muscle strength and spasticity levels of both the quadriceps and hip adductors of adolescents 14 to 19 years of age with spastic cerebral palsy using a specific static bicycle (Thera-Vital exerciser. Eight students were assigned to the experimental group and another 8 to the control group. The strengthening program took place 3 times a week (6 sets of 10 to 15 full cycling circles. The Gross Motor Function Measure (GMFM (dimensions D and E, an isometric hand-held dynamometer and Asworth scale were the measurement instruments used in the study. A multivariance analysis of variance (MANOVA was applied for identifying the statistical importance of the results of the intervention protocol. A statistically significant improvement in both gross motor function (p = 0.016 and muscle strength (p = 0.039 was found without a statistically significant alteration of the muscle tone of the quadriceps and hip adductors of the participants (p = 0.13 and p = 0.33. The results of the present study indicate that static bicycle is a safe and effective means of exercise since it improves the gross motor function of adolescents with cerebral palsy without increasing the muscle tone of the lower limb.

  12. A Bicycle-Based Field Measurement System for the Study of Thermal Exposure in Cuyahoga County, Ohio, USA.

    Science.gov (United States)

    Rajkovich, Nicholas B; Larsen, Larissa

    2016-01-25

    Collecting a fine scale of microclimate data can help to determine how physical characteristics (e.g., solar radiation, albedo, sky view factor, vegetation) contribute to human exposure to ground and air temperatures. These data also suggest how urban design strategies can reduce the negative impacts of the urban heat island effect. However, urban microclimate measurement poses substantial challenges. For example, data taken at local airports are not representative of the conditions at the neighborhood or district level because of variation in impervious surfaces, vegetation, and waste heat from vehicles and buildings. In addition, fixed weather stations cannot be deployed quickly to capture data from a heat wave. While remote sensing can provide data on land cover and ground surface temperatures, resolution and cost remain significant limitations. This paper describes the design and validation of a mobile measurement bicycle. This bicycle permits movement from space to space within a city to assess the physical and thermal properties of microclimates. The construction of the vehicle builds on investigations of the indoor thermal environment of buildings using thermal comfort carts.

  13. A Bicycle-Based Field Measurement System for the Study of Thermal Exposure in Cuyahoga County, Ohio, USA

    Directory of Open Access Journals (Sweden)

    Nicholas B. Rajkovich

    2016-01-01

    Full Text Available Collecting a fine scale of microclimate data can help to determine how physical characteristics (e.g., solar radiation, albedo, sky view factor, vegetation contribute to human exposure to ground and air temperatures. These data also suggest how urban design strategies can reduce the negative impacts of the urban heat island effect. However, urban microclimate measurement poses substantial challenges. For example, data taken at local airports are not representative of the conditions at the neighborhood or district level because of variation in impervious surfaces, vegetation, and waste heat from vehicles and buildings. In addition, fixed weather stations cannot be deployed quickly to capture data from a heat wave. While remote sensing can provide data on land cover and ground surface temperatures, resolution and cost remain significant limitations. This paper describes the design and validation of a mobile measurement bicycle. This bicycle permits movement from space to space within a city to assess the physical and thermal properties of microclimates. The construction of the vehicle builds on investigations of the indoor thermal environment of buildings using thermal comfort carts.

  14. Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics.

    Science.gov (United States)

    Ling, Baoping; Dong, Lihua; Zhang, Rui; Wang, Zhiguo; Liu, Yongjun; Liu, Chengbu

    2010-11-01

    X-linked IAP can bind caspase-9 and inhibit its activity. Mitochondrial protein Smac/DIABLO can also interact with XIAP and relieve the inhibition on caspase-9 to induce apoptosis. A series of artificial Smac mimetics have been used to mimic the Smac N-terminal tetrapeptide AVPI to bind to XIAP-BIR3, but these structural diverse mimetics exhibited distinct binding affinities. To get an insight into the binding nature and optimize the structures, molecular docking and dynamics simulations were used to study the binding of XIAP-BIR3 with three groups of Smac mimetics. The docking results reveal that these Smac mimetics anchored on the surface groove of XIAP-BIR3 and superimposed well with AVPI. The modifications on the seven-membered ring of bicyclic core segment do not strengthen the binding affinity, while a benzyl introduced to the five-membered ring is favorable to the binding. Molecular dynamics simulations on three typical systems show that these complexes are very stable. Hydrogen bonds between the bicyclic core segment and Thr308 play critical roles in maintaining the stability of complex. The binding free energies calculated by MM_PBSA method are consistent with the experimental results. PMID:20980180

  15. [Myocardial ischemia caused by the injection of dipyridamole followed by low level exertion on an exercise bicycle].

    Science.gov (United States)

    Cottin, Y; Morelon, P; André, F; Touzery, C; Brunotte, F; Wolf, J E; Louis, P

    1993-05-01

    The purpose of this study was the feasibility, safety and analysis of the ischemic nature of the association of an injection of dipyridamole and an exercise test at low level exertion on an exercise bicycle for 4 minutes. The ischemic nature of this combination was assessed on the basis of three criteria: the onset of angina-type pain, electrical changes and scintigraphic abnormalities. The test could be carried out by all patients and the most common adverse events were headache (6.5%) and heartburn (3.5%). The 17 patients in this study who had one or more stenoses in excess of 70% presented with angina-type pain (3/17); electrical abnormalities (9/17) and scintigraphic abnormalities in all cases. Of the six patients who had lesions between 50 and 70%, 1 presented with angina symptoms, 2 with electrical abnormalities and 5 with scintigraphic abnormalities. Seven patients in this study showed no significant lesions when subjected to coronary artery angiography. However, angina-type pain and electrical signs were observed in 2 cases and one false positive result by scintigraphy. This study shows that it is possible to combine the injection of dipyridamole with an exercise test involving a low level of exertion on an exercise bicycle which gives a good diagnostic value to the CT scan. The frequency of clinical and electrical signs of ischemia makes it necessary to take the same precautions as for a peak exercise test. PMID:8368796

  16. Using city-wide mobile noise assessments to estimate bicycle trip annual exposure to Black Carbon.

    Science.gov (United States)

    Dekoninck, Luc; Botteldooren, Dick; Int Panis, Luc

    2015-10-01

    Several studies have shown that a significant amount of daily air pollution exposure, in particular Black Carbon (BC), is inhaled during bicycle trips. Previously, the instantaneous BC exposure of cyclists was modeled as the sum of a background concentration and a local traffic related component based on a local assessment of traffic noise. We present a fast and low cost methodology to achieve a city-wide assessment of yearly average BC exposure of cyclists along their trips, based on a city-wide mobile noise sensing campaign. The methodology requires participatory sensing measurements of noise, partially combined with BC and/or other air pollutants sensitive to local traffic variations. The combined measurements cover the spatial and meteorological variability and provide the data for an instantaneous exposure model. The mobile noise-only measurements map the full city; and yearly meteorology statistics are used to extrapolate the instantaneous exposure model to a yearly average map of in-traffic air pollution exposure. Less than four passages at each segment along the network with mobile noise equipment are necessary to reach a standard error of 500 ng/m(3) for the yearly average BC exposure. A strong seasonal effect due to the BC background concentration is detected. The background contributes only 25% to the total trip exposure during spring and summer. During winter the background component increases to 50-60%. Engine related traffic noise along the bicyclist's route is a valid indicator of the BC exposure along the route, independent of the seasonal background. Low exposure route selection results in an exposure reduction of 35% in winter and 60% in summer, sensitive to the weather conditions, specific trip attributes and the available alternatives. The methodology is relevant for further research into the local effects of air pollution on health. Mobile noise mapping adds local traffic data including traffic dynamics into the air pollution exposure

  17. Electric Bicycle Related Injury and Risk Factors in Hangzhou%杭州市电动自行车伤害状况及影响因素

    Institute of Scientific and Technical Information of China (English)

    吴欧; 刘庆敏

    2012-01-01

    In China, there were about 30 million electric bicycles by 2007. The sharp increase of electric bicycles in use led to a rise of related traffic accidents and became an important public health problem. There were about 660000 electric bicycles in Hangzhou city by 2007. The causes of rising electric bicycle usage were complicated. In 2010, the deaths of electric bicycle accidents accounted for 23.39% of all fatalities of traffic accidents in Hangzhou. The leading cause to death was brain injury. These electric bicycle accidents were caused by various factors. After correlation analysis, prevention measures were proposed in this article, such as enhancing traffic management, social publicity of traffic safety (I.e. Community education), manufacturers' technology in safety control, as well as cyclists and pedestrians' self-protection. The article aims to provide reference for electric bicycle injury prevention and control.%在中国大陆,电动自行车使用量急剧上升,到2007年已有3000多万辆,相关交通事故也不断增加,电动自行车伤害成为一个重要公共卫生问题.杭州市电动自行车数量快速增长,到2007年底已有66万辆,电动自行车数量增多原因较为复杂.2010年杭州市涉及电动自行车伤害死亡人数占交通事故死亡人数比例达23.39%,颅脑损伤是造成电动自行车驾驶员死亡的主要原因.电动自行车伤害发生影响因素涉及多个方面.本研究拟通过相关分析,针对性地提出预防措施,如加强交通管理,社会宣传含社区教育、厂商技术改进、骑车人和行人自我保护等,以期对电动自行车伤害防制提供有益参考.

  18. Mortalidade devido a acidentes de bicicletas em Pernambuco, Brasil Mortality due to bicycle accidents in Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Reginaldo Inojosa Carneiro Campello

    2013-05-01

    Full Text Available O artigo tem por objetivo analisar os casos de morte nos acidentes com bicicleta ocorridos em Pernambuco entre 2001 e 2010. Este estudo quantitativo analisou dados secundários. A amostra consistiu de todas as Declarações de Óbitos registradas no Sistema de Informação de Mortalidade do Banco de Dados do Sistema Único de Saúde que relataram acidentes de bicicleta entre 2001 e 2010. Medidas descritivas foram determinadas para todas as variáveis. As sociodemográficas foram cruzadas com a causa básica de morte em busca de correlação estatística. Em Pernambuco, no citado sistema de informação, foram registradas 517 Declarações de Óbitos decorrentes de acidentes de bicicleta, sendo nestes sinistros a participação mais frequente de homens, entre 25-59 anos, pardos, solteiros e de escolaridade ignorada. A idade média foi de 36,82 anos (desvio padrão = 17,026, sendo a idade mínima e a máxima, respectivamente, 4 e 86 anos. Os achados apontam para a necessidade da criação de infraestrutura adequada e de medidas legais efetivas para prevenir acidentes de tráfego envolvendo este tipo de veículo, apoiando-se na evidência de distribuição de casos na maioria dos municípios de Pernambuco.The scope of this paper was to conduct a quantitative analysis of deaths resulting from bicycle accidents in the state of Pernambuco by studying secondary data between 2001 and 2010. The sample consisted of all the Deaths recorded in the Mortality Information System of the Unified Health System Database that reported bicycle accidents between 2001 and 2010. Descriptive measures were determined for all variables. Socio-demographic variables were paired with the basic cause of death in order to find a statistical correlation. In Pernambuco, the aforementioned information system recorded 517 deaths resulting from bicycle accidents, with greater frequency in men between 25 and 59 years of age, Afro-Brazilians, single and of unknown schooling. The mean

  19. 踏车而飞:自行车与中国骑车人(1868-1949 年)[A History of the Bicycle and Chinese Cyclists, 1868-1949

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2012-06-01

    Full Text Available Of the many “exotic” commodities from the West that have changed the lifestyle of the Chinese people over the course of the past two centuries, the bicycle stands out as a prominent example. It has so thoroughly transformed the Chinese mode of transportation that China in the late twentieth century was known as “the kingdom of bicycles.” This essay examines the history of that transformation. The first recorded importation of bicycles to Shanghai took place in 1868. Initially rejected by prospective customers for their incompatibility with Chinese cultural and social conventions, bicycles eventually gained visibility on the streets of many cities and suburbs. The bicycle meant many different things to different sectors of the population, and the social meaning of the bike also changed over time.The first section of this article offers an overview of modern Chinese cyclists. The author argues that early adopters were Manchu aristocrats and wealthy individuals who sported their bicycles on bumpy roads for the sheer enjoyment of the bike’s exotic quality. The second section of the article examines the story of Pu Yi, the last Qing ruler, and bikers in the Forbidden City. The third section examines women bike riders in China. The author presents evidence to show that cycling carried no liberating connotations for modern Chinese women. By the 1930s, bicycles had lost their exotic quality. They also came to be associated with the comings and goings of urban working people, when cars became the vehicles of the social and economic elite. The outbreak of the Sino-Japanese War (1937-45 created a petroleum shortage that grounded all private cars. Bicycles then emerged as the common mode of transportation for the rich as well as the poor, men as well as women. It was the war that laid the foundation for China’s modern transformation into a nation of bicycles.Note: Article is in Chinese.

  20. Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei

    Directory of Open Access Journals (Sweden)

    Diaa T. A. Youssef

    2014-04-01

    Full Text Available In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamide G (1. The structure of the peptide was determined using extensive 1D and 2D NMR and high-resolution mass spectral determinations. The absolute configuration of theonellamide G was determined by chemical degradation and 2D NMR spectroscopy. Theonellamide G showed potent antifungal activity towards wild and amphotericin B-resistant strains of Candida albicans with IC50 of 4.49 and 2.0 μM, respectively. Additionally, it displayed cytotoxic activity against the human colon adenocarcinoma cell line (HCT-16 with IC50 of 6.0 μM. These findings provide further insight into the chemical diversity and biological activities of this class of compounds.

  1. Organocatalytic Asymmetric Conjugate Additions to Cyclopent-1-enecarbaldehyde: A Critical Assessment of Organocatalytic Approaches towards the Telaprevir Bicyclic Core.

    Science.gov (United States)

    Bernardi, Luca; Fochi, Mariafrancesca; Carbone, Riccardo; Martinelli, Ada; Fox, Martin E; Cobley, Christopher J; Kandagatla, Bhaskar; Oruganti, Srinivas; Dahanukar, Vilas H; Carlone, Armando

    2015-12-21

    In the context of a programme directed at the manufacture of telaprevir, eight possible approaches to its bicyclic α-amino acid core, based on organocatalytic enantioselective conjugate additions to cyclopent-1-enecarbaldehyde, were identified and preliminarily explored. Four reactions, delivering advanced intermediates en route to the target amino acid, were selected for a thorough optimisation. Three of this reactions involved iminium ion catalysis with a prolinol catalyst (addition of nitromethane, nitroacetate and acetamidomalonate) and one was based on a Cinchona-derived phase-transfer catalyst (addition of glycine imines). A careful choice of additives allowed lowering of the catalyst loading to 0.5 mol% in some cases. The preparation of intermediates that would give access to the core of telaprevir in good yields and enantioselectivities by exploiting readily available substrates and catalysts, highlights the potential of organocatalytic technology for a cost-effective preparation of pharmaceuticals. PMID:26602867

  2. Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.

    Science.gov (United States)

    Narita, Koichi; Fukui, Yurie; Sano, Yui; Yamori, Takao; Ito, Akihiro; Yoshida, Minoru; Katoh, Tadashi

    2013-02-01

    The bicyclic depsipeptide histone deacetylase (HDAC) inhibitors spiruchostatins C and D were synthesized for the first time in a highly convergent and unified manner. The method features the amide coupling of a D-leucine-D-cysteine- or D-valine-D-cysteine-containing segment with a D-alanine- or D-valine-containing segment to directly assemble the corresponding seco-acids, key precursors of macrolactonization. The HDAC inhibitory assay and cell-growth inhibition analysis of the synthesized depsipeptides determined the order of potency of spiruchostatins A-D in comparison with the clinically approved depsipeptide FK228 (romidepsin). Novel aspects of structure-activity relationships (SAR) were revealed. PMID:23313638

  3. Vibration test and analysis of Laoshan bicycle gymnasium for the Olympic Games under multi-support excitations

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The vibration tests of Laoshan bicycle gymnasium for the Olympic Games are performed under multi-support excitations in order to verify the effectiveness of multi-support time history method. The excitation sources come from the impact forces acting on the ring beam of the reticulated structure, on the basis of which the records of motions of each excited point and corresponding structural vibration responses are all collected. The theoretical analytical model of the structure is further established and the structural dynamic responses are obtained subjected to the same excitation case via multi-support time history method. The calculation results are generally in agreement with those of the test in both time domain and frequency domain, which verify the effectiveness of multi-support time history method. The vibration test can also provide references for long-span structures under multi-support excitations.

  4. The influence of speed, cyclists' age, pedaling frequency, and observer age on observers' time to arrival judgments of approaching bicycles and e-bikes.

    Science.gov (United States)

    Schleinitz, Katja; Petzoldt, Tibor; Krems, Josef F; Gehlert, Tina

    2016-07-01

    Given their potential to reach higher speed levels than conventional bicycles, the growing market share of e-bikes has been the reason for increased concerns regarding road safety. Previous studies have shown a clear relationship between object approach speed and an observers' judgment of when the object would reach a predefined position (i.e., time to arrival, TTA), with higher speed resulting in longer TTA estimates. Since TTA estimates have been linked to road users' decisions of whether or not to cross or turn in front of approaching vehicles, the higher potential speeds of e-bikes might result in an increased risk for traffic conflicts. The goal of the two experiments presented in this paper was to examine the influence of speed and a variety of other factors on TTA estimation for conventional bicycles and for e-bikes. In both experiments, participants from two age groups (20-45 years old and 65 years or older) watched video sequences of bicycles approaching at different speeds (15-25km/h) and were asked to judge the TTA at the moment the video was stopped. The results of both experiments showed that an increase in bicycle approach speed resulted in longer TTA estimates (measured as the proportion of estimated TTA relative to actual TTA) for both bicycle types (ηp(2)Exp.1=.489, ηp(2)Exp.2=.705). Compared to younger observers, older observers provided shorter estimates throughout (Exp. I: MDiff=0.35, CI [0.197, 0.509], ηp(2)=.332, Exp. II: MDiff=0.50, CI [.317, 0.682], ηp(2)=.420). In Experiment I, TTA estimates for the conventional bicycle were significantly shorter than for the e-bike (MDiff=0.03, CI [.007, 0.044], ηp(2)=.154), as were the estimates for the elder cyclist compared to the younger one (MDiff=0.05, CI [.025, 0.066], ηp(2)=.323). We hypothesized that the cause for this effect might lie in the seemingly reduced pedaling effort for the e-bike as a result of the motor assistance it provides. Experiment II was able to show that a high pedaling

  5. The E-bike : opportunities for commuter traffic. The potentials of using electric bicycles and –scooters in commuting traffic in relation to energy use, local emissions and the accessibility of a compact Dutch city

    NARCIS (Netherlands)

    Engelmoer, Wiebe

    2012-01-01

    SUMMARY The electric bicycle and -scooter are entering the personal mobility market quickly due to a number of advantages over conventional modes of personal mobility. However, the effects of this relative new mode of transport are quite unknown. Therefo

  6. Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.

    Science.gov (United States)

    Hamaguchi, Hisao; Kosaka, Shohei; Ohno, Hiroaki; Fujii, Nobutaka; Tanaka, Tetsuaki

    2007-01-01

    A highly regioselective synthesis of bicyclic sulfamides is described. Based on our recent discovery that bromoallenes can act as allyl dication equivalents in the presence of a palladium catalyst and alcohol, we investigated tandem cyclization of bromoallenes bearing a sulfamide group. It is found that some bromoallenes act as allyl dication equivalents even in the absence of a palladium(0) catalyst to afford cyclosulfamides containing five- or six-membered rings. While the palladium-free cyclization is dependent on the substrate structure affording the bicyclic sulfamides through the first cyclization onto the proximal or central carbon atom of the bromoallenes, the palladium-catalyzed reaction strongly promotes the first cyclization onto the central allenic carbon atom to afford bicyclic sulfamides containing a seven- or eight-membered ring. Formation of two types of bicyclic sulfamides from single bromoallenes by simply changing the reaction conditions is also described. PMID:17200916

  7. [Comparison of the results of transesophageal electrical stimulation of the left atrium, bicycle ergometry and selective coronary angiography in diagnosing ischemic heart disease].

    Science.gov (United States)

    Sidorenko, B A; Savchenko, A P; Liakishev, A A; Kozlov, S G; Klembovskiĭ, A A

    1985-11-01

    The clinical picture and results of bicycle ergometry and selective coronarography were compared with data obtained by esophageal electric stimulation of the left atrium in 108 patients with suspected coronary disease. It was demonstrated that esophageal left-atrial electrostimulation could be used as noninvasive load test for coronary disease. Ischemic electrocardiographic changes, induced by esophageal stimulation showed good correlation to the clinical manifestation of angina pectoris and the severity of coronary atherosclerosis. The sensitivity of esophageal stimulation in the diagnosis of hemodynamically-significant coronary atherosclerosis was 82%, its specificity was 76%, the predictive value of positive results was 82%, and the predictive value of negative results, 76%, that is, essentially the same as the respective parameters of bicycle ergometry.

  8. Application of flow pattern heart rate test system in electric bicycle%流谱心率系统在电动自行车上的应用

    Institute of Scientific and Technical Information of China (English)

    崔立宝; 于新昌; 崔悦; 尔洪斌; 于红丽

    2013-01-01

    介绍了心率监控系统在电动自行车上的应用,在骑行电动自行车过程中,通过车把传感器进行心率实时监控,当骑行人心率体征发生变化时系统可以及时报警,减少因为骑行人体征变化引起的交通事故,从而引领人们健康生活的理念。%The application of heart rate monitoring system in electric bicycle is introduced. In the process of riding electric bicycle,the rate is real-time monitored by the handlebar sensor,it can timely alarm when the heart rate and signs of the rider changed,thus reduce the traffic accident. Then lead the concept of healthy life for people.

  9. SYNTHESIS OF NOVEL BICYCLIC AND TRICYCLIC THIAZOLE AND IMIDAZOLE CONTAINING 2-AMINOPROPIONIC ACIDS Synthese von neuartigen bicyclischen und tricyclischen THIAZOLE und Imidazol MIT 2-Aminopropionsäuren

    Directory of Open Access Journals (Sweden)

    Tatjana Beresneva, Edgars Abele

    2011-04-01

    Full Text Available Synthesis of four novel bicyclic and tricyclic amino acids (2-amino-3-benzo[4,5]imidazo[2,1- b]thiazol-3-ylpropionic acid, 2-amino-3-benzo[d]imidazo[2,1-b]thiazol-2-ylpropionic acid, 2- amino-3-thiazolo[3,2-b][1,2,4]triazol-6-ylpropionic acid, 2-amino-3-(2- methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-ylpropionic acid were carried out.

  10. Public Bicycles: How the Concept of Human-Oriented “Mobility Sharing” Technology Can Influence Travel Behaviour Norms and Reshape Design Education

    OpenAIRE

    Nikitas, Alexandros; Wallgren, Pontus; Rahe, Ulrike

    2014-01-01

    Although at the moment an excess of 500 public bicycle schemes of variable sizes operate in almost 50 countries worldwide, the impact of their use on travel behaviour and modal change have neither been studied extensively nor have been understood thoroughly as yet. This work negotiates the initial stages of an international research scheme that means to look into the attitudes and system user experiences (the latter only when it is applicable) that could define the design (or re-design) crite...

  11. Fatalities of Pedestrians, Bicycle Riders, and Motorists Due to Distracted Driving Motor Vehicle Crashes in the U.S., 2005–2010

    Science.gov (United States)

    Wilson, Fernando A.; Muelleman, Robert L.

    2013-01-01

    Objective Distracted driving is an increasingly deadly threat to road safety. This study documents trends in and characteristics of pedestrian, bicycle rider, and other victim deaths caused by distracted drivers on U.S. public roads. Methods We obtained data from the Fatality Analysis Reporting System database from 2005 to 2010 on every crash that resulted in at least one fatality within 30 days occurring on public roads in the U.S. Following the definition used by the National Highway Traffic Safety Administration, we identified distracted driving based on whether police investigators determined that a driver had been using a technological device, including a cell phone, onboard navigation system, computer, fax machine, two-way radio, or head-up display, or had been engaged in inattentive or careless activities. Results The rate of fatalities per 10 billion vehicle miles traveled increased from 116.1 in 2005 to 168.6 in 2010 for pedestrians and from 18.7 in 2005 to 24.6 in 2010 for bicyclists. Pedestrian victims of distracted driving crashes were disproportionately male, 25–64 years of age, and non-Hispanic white. They were also more likely to die at nighttime, be struck by a distracted driver outside of a marked crosswalk, and be in a metro location. Bicycling victims of distracted crashes were disproportionately male, non-Hispanic white, and struck by a distracted driver outside of a crosswalk. Compared with pedestrians, bicyclists were less likely to be hit in early morning. Conclusions Distracted drivers are the cause of an increasing share of fatalities found among pedestrians and bicycle riders. Policies are needed to protect pedestrians and bicycle riders as they cross intersections or travel on roadways. PMID:24179255

  12. Does the effect of micro-environmental factors on a street's appeal for adults' bicycle transport vary across different macro-environments?: an experimental study

    OpenAIRE

    Lieze Mertens; Jelle Van Cauwenberg; Ariane Ghekiere; Veerle Van Holle; Ilse De Bourdeaudhuij; Benedicte Deforche; Jack Nasar; Nico Van de Weghe; Delfien Van Dyck

    2015-01-01

    Background : Characteristics of the physical environment can be classified into two broad categories: macro-("raw" urban planning features influenced on a regional level) and micro-(features specifically within a streetscape influenced on a neighborhood level) environmental factors. In urban planning applications, it is more feasible to modify conditions at the neighborhood level than at the regional level. Yet for the promotion of bicycle transport we need to know whether relationships betwe...

  13. Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support

    DEFF Research Database (Denmark)

    Oddo, Alberto; Münzker, Lena; Hansen, Paul Robert

    2015-01-01

    A convenient strategy for the on-resin synthesis of macrocyclic peptides (3- to 13-mers) via intramolecular halide substitution by a diamino acid is described. The method is compatible with standard Fmoc/tBu SPPS and affords a tail-to-side-chain macrocyclic peptide featuring an endocyclic seconda...... amine. This functional group is still reactive toward acylation, allowing for the continuation of the synthesis. An application to the synthesis of lipidated cyclic and bicyclic antimicrobial peptides is presented....

  14. Parent-child interactive exploration and research of bicycle%亲子互动型儿童自行车的探索与研究

    Institute of Scientific and Technical Information of China (English)

    韩文婷; 秦笃印

    2013-01-01

    基于对儿童心理与需求的研究,对市场现有儿童自行车进行研究与改造。从心理学角度分析儿童在学习使用自行车的过程当中会产生的问题以及应该如何解决。并且对亲子互动如何在儿童自行车上进行设计体现的进行研究和探讨。%Based on the study of children's psychology and demand, existing children bicycle to the market research and reform. From the psychology Angle analysis of children in the process of learning to use a bicycle can produce problems and should be how to solve. And to the parent-child interaction design reflects on how to in children bicycle are studied and discussed.

  15. 岳阳市公共自行车设施现状调查与思考%An Assessment of the Public Bicycle Facilities in Yueyang

    Institute of Scientific and Technical Information of China (English)

    曹诗怡

    2015-01-01

    This paper evaluates the effects of the public bicycle rental system in Yueyang based on the study of Yueyang City public bicycle distribution and operation of the site and proposes the development of a public bicycle must pay attention to the rational distribution planning bike sites, strengthen infrastructure construction, improve the public bike model species, clear direction of public bike system for the city's public bike system provides the basis for orderly development.%在考察岳阳市城市公共自行车站点分布及运行情况的基础上,对岳阳市公共自行车租赁系统运行的实际效果进行综合评价,提出了发展公共自行车必须合理布局自行车站点,加强基础设施配套建设,健全公共自行车的车型种类等改进建议,明晰公共自行车系统的发展方向,促进城市公共自行车系统的有序发展.

  16. Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    DEFF Research Database (Denmark)

    Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R;

    2005-01-01

    The X-ray structure of the ionotropic GluR2 ligand-binding core (GluR2-S1S2J) in complex with the bicyclical AMPA analogue (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]-4-isoxazolyl)propionic acid [(S)-4-AHCP] has been determined, as well as the binding pharmacology of this construct...... and of the full-length GluR2 receptor. (S)-4-AHCP binds with a glutamate-like binding mode and the ligand adopts two different conformations. The K(i) of (S)-4-AHCP at GluR2-S1S2J was determined to be 185 +/- 29 nM and at full-length GluR2(R)o it was 175 +/- 8 nM. (S)-4-AHCP appears to elicit partial agonism...... at GluR2 by inducing an intermediate degree of domain closure (17 degrees). Also, functionally (S)-4-AHCP has an efficacy of 0.38 at GluR2(Q)i, relative to (S)-glutamate. The proximity of bound (S)-4-AHCP to domain D2 prevents full D1-D2 domain closure, which is limited by steric repulsion, especially...

  17. Insights in Public Health: Initiating Bicycle Sharing in Hawai'i: Lessons Learned from a Small Pilot Bike Share Program.

    Science.gov (United States)

    Choy, Lehua B; Smith, Heidi Hansen; Espiritu, Justine; Higa, Earl; Lee, Thomas; Maddock, Jay

    2015-10-01

    In 2011, a small pilot bike share program was established in the town core of Kailua, Hawai'i, with funding from the Hawai'i State Department of Health. The Kailua system consisted of two stations with 12 bicycles, and the goal was to secure additional funding to expand the station network in the future. Community feedback consistently indicated support for the bike share program. However, system metrics showed low levels of usage, averaging 41.5 rides per month (2011-2014). From observational data, users were primarily tourists. With minimal local staff, the bike share program had limited resources for promotion and education, which may have hindered potential use by local residents. Management of station operations and bike maintenance were additional, ongoing barriers to success. Despite the challenges, the pilot bike share program was valuable in several ways. It introduced the bike share concept to Hawai'i, thereby helping to build awareness and connect an initial network of stakeholders. Furthermore, the pilot bike share program informed the development of a larger bike share program for urban Honolulu. As limited information exists in the literature about the experiences of smaller bike share programs and their unique considerations, this article shares lessons learned for other communities interested in starting similar bike share programs. PMID:26535166

  18. Nonuse of bicycle helmets and risk of fatal head injury: a proportional mortality, case–control study

    Science.gov (United States)

    Persaud, Navindra; Coleman, Emily; Zwolakowski, Dorothy; Lauwers, Bert; Cass, Dan

    2012-01-01

    Background: The effectiveness of helmets at preventing cycling fatalities, a leading cause of death among young adults worldwide, is controversial, and safety regulations for cycling vary by jurisdiction. We sought to determine whether nonuse of helmets is associated with an increased risk of fatal head injury. Methods: We used a case–control design involving 129 fatalities using data from a coroner’s review of cycling deaths in Ontario, Canada, between 2006 and 2010. We defined cases as cyclists who died as a result of head injuries; we defined controls as cyclists who died as a result of other injuries. The exposure variable was nonuse of a bicycle helmet. Results: Not wearing a helmet while cycling was associated with an increased risk of dying as a result of sustaining a head injury (adjusted odds ratio [OR] 3.1, 95% confidence interval [CI] 1.3–7.3). We saw the same relationship when we excluded people younger than 18 years from the analysis (adjusted OR 3.5, 95% CI 1.4–8.5) and when we used a more stringent case definition (i.e., only a head injury with no other substantial injuries; adjusted OR 3.6, 95% CI 1.2–10.2). Interpretation: Not wearing a helmet while cycling is associated with an increased risk of sustaining a fatal head injury. Policy changes and educational programs that increase the use of helmets while cycling may prevent deaths. PMID:23071369

  19. The potential modal shift and health benefits of implementing a public bicycle share program in Montreal, Canada

    Science.gov (United States)

    2013-01-01

    Background This study estimated the modal shift associated with the implementation of a public bicycle share program in Montreal, Canada. Methods A population-based sample of adults participated in two cross sectional telephone surveys. Self-reported travel behaviors were collected at the end of the first (fall 2009) and second (fall 2010) season of implementation. The sample included 2502 (Mean age=47.8 years, 61.8% female), and 2509 (Mean age=48.9 years, 59.0% female) adult respondents in each survey. Results The estimated modal shift associated with the implementation of the PBSP from motor vehicle use to walking, cycling, and public transportation was 6483 and 8023 trips in 2009 and 2010. This change represents 0.34% and 0.43% of all motor vehicle trips in Montreal. Conclusions The implementation of a PBSP was associated with a shift toward active transportation. The modal shift was complex and not simply the result of a discrete shift from one mode to another. Promotion of active transportation should encourage integration of multiple active transportation modes to better reflect people’s actual transportation behaviors. PMID:23705934

  20. Buses, cars, bicycles and walkers: the influence of the type of human transport on the flight responses of waterbirds.

    Directory of Open Access Journals (Sweden)

    Emily M McLeod

    Full Text Available One way to manage disturbance to waterbirds in natural areas where humans require access is to promote the occurrence of stimuli for which birds tolerate closer approaches, and so cause fewer responses. We conducted 730 experimental approaches to 39 species of waterbird, using five stimulus types (single walker, three walkers, bicycle, car and bus selected to mimic different human management options available for a controlled access, Ramsar-listed wetland. Across species, where differences existed (56% of 25 cases, motor vehicles always evoked shorter flight-initiation distances (FID than humans on foot. The influence of stimulus type on FID varied across four species for which enough data were available for complete cross-stimulus analysis. All four varied FID in relation to stimuli, differing in 4 to 7 of 10 possible comparisons. Where differences occurred, the effect size was generally modest, suggesting that managing stimulus type (e.g. by requiring people to use vehicles may have species-specific, modest benefits, at least for the waterbirds we studied. However, different stimulus types have different capacities to reduce the frequency of disturbance (i.e. by carrying more people and vary in their capacity to travel around important habitat.

  1. Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.

    Science.gov (United States)

    Shen, Sida; Benoy, Veronick; Bergman, Joel A; Kalin, Jay H; Frojuello, Mariana; Vistoli, Giulio; Haeck, Wanda; Van Den Bosch, Ludo; Kozikowski, Alan P

    2016-02-17

    Charcot-Marie-Tooth (CMT) disease is a disorder of the peripheral nervous system where progressive degeneration of motor and sensory nerves leads to motor problems and sensory loss and for which no pharmacological treatment is available. Recently, it has been shown in a model for the axonal form of CMT that histone deacetylase 6 (HDAC6) can serve as a target for the development of a pharmacological therapy. Therefore, we aimed at developing new selective and activity-specific HDAC6 inhibitors with improved biochemical properties. By utilizing a bicyclic cap as the structural scaffold from which to build upon, we developed several analogues that showed improved potency compared to tubastatin A while maintaining excellent selectivity compared to HDAC1. Further screening in N2a cells examining both the acetylation of α-tubulin and histones narrowed down the library of compounds to three potent and selective HDAC6 inhibitors. In mutant HSPB1-expressing DRG neurons, serving as an in vitro model for CMT2, these inhibitors were able to restore the mitochondrial axonal transport deficits. Combining structure-based development of HDAC6 inhibitors, screening in N2a cells and in a neuronal model for CMT2F, and preliminary ADMET and pharmacokinetic profiles, resulted in the selection of compound 23d that possesses improved biochemical, functional, and druglike properties compared to tubastatin A.

  2. Insights in Public Health: Initiating Bicycle Sharing in Hawai'i: Lessons Learned from a Small Pilot Bike Share Program.

    Science.gov (United States)

    Choy, Lehua B; Smith, Heidi Hansen; Espiritu, Justine; Higa, Earl; Lee, Thomas; Maddock, Jay

    2015-10-01

    In 2011, a small pilot bike share program was established in the town core of Kailua, Hawai'i, with funding from the Hawai'i State Department of Health. The Kailua system consisted of two stations with 12 bicycles, and the goal was to secure additional funding to expand the station network in the future. Community feedback consistently indicated support for the bike share program. However, system metrics showed low levels of usage, averaging 41.5 rides per month (2011-2014). From observational data, users were primarily tourists. With minimal local staff, the bike share program had limited resources for promotion and education, which may have hindered potential use by local residents. Management of station operations and bike maintenance were additional, ongoing barriers to success. Despite the challenges, the pilot bike share program was valuable in several ways. It introduced the bike share concept to Hawai'i, thereby helping to build awareness and connect an initial network of stakeholders. Furthermore, the pilot bike share program informed the development of a larger bike share program for urban Honolulu. As limited information exists in the literature about the experiences of smaller bike share programs and their unique considerations, this article shares lessons learned for other communities interested in starting similar bike share programs.

  3. Bicycle safety in bicycle to car accidents

    NARCIS (Netherlands)

    Rodarius, C.; Mordaka, J.K.; Versmissen, A.C.M.

    2008-01-01

    Much attention is being paid to pedestrian safety by international working groups such as EEVC WG17, in research projects such as APROSYS (www.aprosys.com) and consumer organisations like Euro NCAP (www.euroncap.com). In addition legal requirements are in place, like the EU directive 2003/102/EC. Ho

  4. Design of Recreational Body-building Wooden Horse Bicycle%娱乐健身木马车的设计

    Institute of Scientific and Technical Information of China (English)

    谢雄; 赵聪; 廖益丰

    2013-01-01

    The wooden horse carriage and body‐building bicycle are combined as a whole by adopting a chain transmission device and a crank rocker mechanism ,while people trampling the pedal board ,the crank is driven to rotate through the drive sprocket and chain ,then the crank drives the connecting rod and the rocker to move ,and eventually the wooden horse which is fixed on the connecting rod does regular wave motions in a vertical plane .Adults can take care of the children while doing exercise in this case .A spring damper and a loading device with a flywheel disc of high inertia moment are added in the device ,which can weaken the pedals’ bidirectional pulse force in the motion .At the same time ,different people can achieve their ideal exercise .%  通过链条传动装置和曲柄摇杆机构将木马车和健身车结合为一个整体,当蹬踩脚踏板时通过主动链轮和链条带动曲柄转动,继而带动连杆和摇杆运动,最终使固定在连杆上的木马在铅垂面内做有规律的波浪形运动。使大人在照顾小孩的同时锻炼健身。设计中该装置中加入了弹簧阻尼器和带有较大转动惯量飞轮盘的加载装置,以削弱运动过程踏板双向脉冲受力,使不同体质的人都能达到各自理想的锻炼强度。

  5. Infrared and Raman spectra of bicyclic molecules using scaled noncorrelated and correlated {ital ab initio} force fields

    Energy Technology Data Exchange (ETDEWEB)

    Collier, W.B. [Department of Chemistry, Oral Roberts University, Tulsa, Oklahoma 74171 (United States); Magdo, I. [Gedeon Richter Ltd., Molecular Design Unit, P.O. Box 27, H-1475, Budapest (Hungary); Klots, T.D. [Bartlesville Thermodynamic Group, BDM Petroleum Technologies, P.O. Box 2543, Bartlesville, Oklahoma 74005 (United States)

    1999-03-01

    This paper reports the application of a scaled {ital ab initio} calculated harmonic force field to predict the frequencies, infrared intensities, Raman intensities, and depolarization ratios of benzofuran, benzothiophene, indole, benzothiazole, and benzoxazole. The theoretical calculations were made using the Hartree{endash}Fock HF/3-21G{sup {asterisk}} and HF/6-31G{sup {asterisk}} basis sets and density-functional theory (DFT)B3-LYP/6-31G{sup {asterisk}} levels. The equilibrium calculated force constants are scaled according to the method of Pulay and compared with the experimentally determined frequencies, intensities, and depolarization ratios to assess the accuracy and fit of the theoretical calculation. Methods for quantitative comparison of intensities were developed. The double numerical differentiation algorithm of Komornicki and McIver was analyzed and used to calculate the Raman intensities for the (DFT)B3-LYP/6-31G{sup {asterisk}} model. The (DFT)B3-LYP/6-31G{sup {asterisk}} model is approaching the harmonic limit in the planar and nonplanar refinement of these bicyclics with wave number fits of 5 and 4 cm{sup {minus}1}, respectively. It reduces the need for scale factors and increases their transfer accuracy, largely because the scale factors values cluster near unity. The Komornicki and McIver algorithm is still a viable method for calculating Raman intensity information for methods that do not have analytic routines programmed. The main shortcoming to this method may lie in the tighter self-consistent field (SCF) convergence criterion possibly needed to calculate Raman intensities for the totally symmetric modes of large molecules. The (DFT)B3-LYP/6-31G{sup {asterisk}} model was superior for calculating the planar intensities, but equal to the HF methods for predicting the nonplanar intensities. {copyright} {ital 1999 American Institute of Physics.}

  6. 白行车阻滞干扰对交通流的延误影响模型%Modeling Bicycle Block Interference Impaction on Traffic Flow Delays

    Institute of Scientific and Technical Information of China (English)

    王明文; 关宏志:

    2011-01-01

    Traffic flow mixed motor vehicle and bicycle is the main characteristic of the urban traffic in China. Bicycles will cause interference influence on motor vehicles and traffic flow delays in the mixed traffic, which has not been studied comp]etely because of lacking the mathematical model and calculation method. Aiming at the discrete flow and continuous flow respectively, an impact model of traffic flow delays caused by bicycle blockinterference was established according to the probability theory and hydrokinetics simulation theory. To some extent, this model could be used to evaluate the road service level and determine reasonable road resistance function.%机非混合交通流是我国城市交通的一个主要特征,在机非混行路段,自行车对机动车的行驶会造成干扰影响,容易造成交通延误,目前尚缺乏对这种延误进行分析的数学模型和计算方法.本文针对交通流中出现的离散流和连续流的不同情况,分别采用概率论理论和流体动力学理论两种不同的方法提出了机非混行路段的自行车阻滞干扰对交通流的延误影响模型。该模型对于定量分析混合交通中自行车对路段交通流的影响,对于评价路段的服务水平,确定合适的路阻函数等具有重要的意义.

  7. Bicycle helmets are highly effective at preventing head injury during head impact: head-form accelerations and injury criteria for helmeted and unhelmeted impacts.

    Science.gov (United States)

    Cripton, Peter A; Dressler, Daniel M; Stuart, Cameron A; Dennison, Christopher R; Richards, Darrin

    2014-09-01

    Cycling is a popular form of recreation and method of commuting with clear health benefits. However, cycling is not without risk. In Canada, cycling injuries are more common than in any other summer sport; and according to the US National Highway and Traffic Safety Administration, 52,000 cyclists were injured in the US in 2010. Head injuries account for approximately two-thirds of hospital admissions and three-quarters of fatal injuries among injured cyclists. In many jurisdictions and across all age levels, helmets have been adopted to mitigate risk of serious head injuries among cyclists and the majority of epidemiological literature suggests that helmets effectively reduce risk of injury. Critics have raised questions over the actual efficacy of helmets by pointing to weaknesses in existing helmet epidemiology including selection bias and lack of appropriate control for the type of impact sustained by the cyclist and the severity of the head impact. These criticisms demonstrate the difficulty in conducting epidemiology studies that will be regarded as definitive and the need for complementary biomechanical studies where confounding factors can be adequately controlled. In the bicycle helmet context, there is a paucity of biomechanical data comparing helmeted to unhelmeted head impacts and, to our knowledge, there is no data of this type available with contemporary helmets. In this research, our objective was to perform biomechanical testing of paired helmeted and unhelmeted head impacts using a validated anthropomorphic test headform and a range of drop heights between 0.5m and 3.0m, while measuring headform acceleration and Head Injury Criterion (HIC). In the 2m (6.3m/s) drops, the middle of our drop height range, the helmet reduced peak accelerations from 824g (unhelmeted) to 181g (helmeted) and HIC was reduced from 9667 (unhelmeted) to 1250 (helmeted). At realistic impact speeds of 5.4m/s (1.5m drop) and 6.3m/s (2.0m drop), bicycle helmets changed the

  8. Research of psychical processes of bicyclists 12-13 years old under the influence of the specific loading (on material of bicycle moto-cross.

    Directory of Open Access Journals (Sweden)

    Prudnikova М.S.

    2012-02-01

    Full Text Available The psychical motor processes of youths and girls of specialization bicycle moto-cross are considered. In researches took part 19 young bicyclists (12 youths; 7 girls in age 12-13 years during two setup times. Researches were conducted taking into account actual material, with the use of psychological diagnostic methods. The level of the psychological state of youths and girls under act of the physical loadings is shown. It is exposed that in the process of employment sportsmen retain in a center attention the certain number of heterogeneous objects and simultaneously allow to accomplish a few actions at once.

  9. Light-Induced Copper(II) Coordination by a Bicyclic Tetraaza Chelator through a Ligand-to-Metal Charge-Transfer Reaction

    DEFF Research Database (Denmark)

    Holm-Jørgensen, Jacob Rørdam; Jensen, Mikael; Bjerrum, Morten

    2011-01-01

    To enable utilization of the broad potential of copper isotopes in nuclear medicine, rapid and robust chelation of the copper is required. Bowl adamanzanes (bicyclic tetraaza ligands) can form kinetically stable copper complexes, but they are usually formed at low rates unless high pH values...... and high temperatures are applied. We have investigated the effects of the variation in the pH, different anions, and UV irradiation on the chelation rate. UV spectra of mixtures of Cu2+ and [24.31]adz in water show the existence of a longlived two-coordinated copper(II) intermediate (only counting...

  10. Does the Effect of Micro-Environmental Factors on a Street's Appeal for Adults' Bicycle Transport Vary across Different Macro-Environments? An Experimental Study.

    Directory of Open Access Journals (Sweden)

    Lieze Mertens

    Full Text Available Characteristics of the physical environment can be classified into two broad categories: macro- ("raw" urban planning features influenced on a regional level and micro- (features specifically within a streetscape influenced on a neighborhood level environmental factors. In urban planning applications, it is more feasible to modify conditions at the neighborhood level than at the regional level. Yet for the promotion of bicycle transport we need to know whether relationships between micro-environmental factors and bicycle transport depend on different types of macro-environments. This study aimed to identify whether the effect of three micro-environmental factors (i.e., evenness of the cycle path surface, speed limits and type of separation between cycle path and motorized traffic on the street's appeal for adults' bicycle transport varied across three different macro-environments (i.e., low, medium and high residential density street.In total, 389 middle-aged adults completed a web-based questionnaire consisting of socio-demographic characteristics and a series of choice tasks with manipulated photographs, depicting two possible routes to cycle along. Conjoint analysis was used to analyze the data.Although the magnitude of the overall effects differed, in each macro-environment (i.e., low, medium and high residential density, middle-aged adults preferred a speed limit of 30 km/h, an even cycle path surface and a hedge as separation between motorized traffic and the cycle path compared to a speed limit of 50 or 70 km/h, a slightly uneven or uneven cycle path surface and a curb as separation or no separation between motorized traffic and the cycle path.Our results suggest that irrespective of the macro-environment, the same micro-environmental factors are preferred in middle-aged adults concerning the street's appeal for bicycle transport. The controlled environment simulations in the experimental choice task have the potential to inform real life

  11. Application of TL 494 t o Electrically Powered Bicycle Control%TL494在电动助力车控制中的应用

    Institute of Scientific and Technical Information of China (English)

    王培玲; 臧炜

    2001-01-01

    This paper details the basic performances of the in tegrated circuit of TL 494 switch power pulse width modulator and its applicatio n to bicycle powered by DC motor with br ush and briefs some problems which shoul d be noted in dcsign.%本文较详细介绍了TL 494开关电源脉宽调制器集成电路的基本性能和在有刷直流电动助力车中的应用。简要叙述了设计中应注意的问题。

  12. Design of data acquisition system for electric bicycle driver%电动自行车驱动装置数据采集系统的设计

    Institute of Scientific and Technical Information of China (English)

    金桂财; 许万里; 李革臣

    2009-01-01

    文章提出了一种基于USB的数据存储设计方案,介绍了用CH375和单片机设计电动自行车数据采集系统的优点及多通道数据采集、数据传输、数据存储的设计.%This paper proposed a data storage proposal based on USB, introduced the advantages of using CH375 and MCU to design the data acquisition system for electric bicycle, and the designs of multi-channel data acquisition,data transmission and data storage.

  13. Synthesis and conformational analysis of constrained beta-turn mimetics using a bicyclic turn inducer and the Petasis three-component reaction on solid-phase

    OpenAIRE

    Danieli, E; Trabocchi, A.; G. MENCHI; Guarna, A

    2007-01-01

    A new set of β-turn mimetics incorporating a bicyclic turn inducer was achieved by use of the solid-phase Petasis reaction in a stereoselective fashion. The stereoselectivity of the reaction turned out to be dependent on the side chain of the amino acid preceding the reverse turn inducer. The β-turn mimetics were stabilized by strong intramolecular 10-membered ring hydrogen bonds, detected by conformational analysis by NMR and molecular modelling, whilst the turn type was controlled by the fi...

  14. 自行车停车设施规划设计要素%Key Elements in Planning and Design for Bicycle Parking Facilities

    Institute of Scientific and Technical Information of China (English)

    王志高; 刘岱宗

    2014-01-01

    中国很多城市在规划设计自行车停车设施时,目标往往局限于提供基本条件,对提升供给质量的诉求不够强烈。首先指出中国自行车停车设施规划设计存在的突出问题:空间与设施不足、选址不合理、安全问题、使用不便,以及缺乏环境协调。基于此提出自行车停车设施规划设计的核心原则:安全、便利、美观、经济,并进一步总结体现核心原则的12项要素及其具体手段。提出实践中不同类型目的地的停车设施规划设计要素优先级建议,并以案例的形式对各规划设计要素及其优先级进行详细解析。%Lack of the motivation to develop higher quality of bicycle parking facilities, many Chinese cit-ies only go for the“minimal”in planning and designing the bicycle parking facilities. This paper first points out the main problems existed in the current bicycle parking facilities planning and design in China, such as inadequate space and amenities, inappropriate site selection, concern for safety, inconvenience for users, and little consideration for the surrounding environment. The paper then proposes the core designing principles in safety, convenience, aesthetics and economics, which is further elaborated in the 12 key ele-ments and their corresponding concrete measures. How to prioritizes key elements in bicycle parking plan-ning and design for different parking objectives is recommended. Finally the paper presents case studies to illustrate the suggested planning and design process.

  15. Determinantes e padrões de utilização da bicicleta e acidentes de trânsito sofridos por ciclistas trabalhadores da cidade de Pelotas, Rio Grande do Sul, Brasil Determinants and patterns of bicycle use and traffic accidents among bicycling workers in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Giancarlo Bacchieri

    2005-10-01

    Full Text Available Um estudo transversal de base-populacional foi realizado em Pelotas, sul do Brasil, objetivando pesquisar os determinantes e padrões de utilização da bicicleta como modo de transporte para o trabalho. Foram também descritos os acidentes ocorridos nos últimos 12 meses no deslocamento de ida e volta para o trabalho e a utilização de equipamentos de segurança na bicicleta. A amostra incluiu 1.705 trabalhadores com 15 anos ou mais de idade, residentes na zona urbana, que utilizavam modos de transporte para o trabalho. Análises bruta e ajustada foram realizadas por meio de regressão de Poisson, considerando o efeito do delineamento. A prevalência de utilização da bicicleta foi de 17,2% (IC95%: 15,4-19,0. Trabalhadores homens, com baixa escolaridade e nível econômico mais baixo apresentaram as maiores prevalências. Menos de 1,0% das bicicletas possuía os equipamentos de segurança exigidos pelo Código de Trânsito Brasileiro e 15,0% não tinham freios. Aproximadamente 6,0% desses trabalhadores sofreram acidentes de trânsito com lesões corporais nos últimos 12 meses. Concluímos que trabalhadores que utilizam bicicleta como modo de transporte são prioritários para intervenções preventivas relacionadas a acidentes de trânsito.A population-based cross-sectional study was conducted in Pelotas, southern Brazil, focusing on the determinants and patterns of bicycle use as a mode of commuting by workers. Accidents during commuting and use of safety equipment were also studied. The sample included 1,705 workers (> 15 years of age living in the urban area of Pelotas and using various modes of transportation during commuting. Crude and adjusted analyses were performed using Poisson regression, taking the design effect into account. Prevalence of bicycle use was 17.2% (95%CI: 15.4%-19.0%. Male workers and those with low schooling and low income presented higher prevalence. Less than 1.0% of the bicycles featured the safety equipment

  16. The impact of cost and network topology on urban mobility: a study of public bicycle usage in 2 U.S. cities.

    Directory of Open Access Journals (Sweden)

    Raja Jurdak

    Full Text Available Understanding the drivers of urban mobility is vital for epidemiology, urban planning, and communication networks. Human movements have so far been studied by observing people's positions in a given space and time, though most recent models only implicitly account for expected costs and returns for movements. This paper explores the explicit impact of cost and network topology on mobility dynamics, using data from 2 city-wide public bicycle share systems in the USA. User mobility is characterized through the distribution of trip durations, while network topology is characterized through the pairwise distances between stations and the popularity of stations and routes. Despite significant differences in station density and physical layout between the 2 cities, trip durations follow remarkably similar distributions that exhibit cost sensitive trends around pricing point boundaries, particularly with long-term users of the system. Based on the results, recommendations for dynamic pricing and incentive schemes are provided to positively influence mobility patterns and guide improved planning and management of public bicycle systems to increase uptake.

  17. The Impact of Cost and Network Topology on Urban Mobility: A Study of Public Bicycle Usage in 2 U.S. Cities

    Science.gov (United States)

    Jurdak, Raja

    2013-01-01

    Understanding the drivers of urban mobility is vital for epidemiology, urban planning, and communication networks. Human movements have so far been studied by observing people's positions in a given space and time, though most recent models only implicitly account for expected costs and returns for movements. This paper explores the explicit impact of cost and network topology on mobility dynamics, using data from 2 city-wide public bicycle share systems in the USA. User mobility is characterized through the distribution of trip durations, while network topology is characterized through the pairwise distances between stations and the popularity of stations and routes. Despite significant differences in station density and physical layout between the 2 cities, trip durations follow remarkably similar distributions that exhibit cost sensitive trends around pricing point boundaries, particularly with long-term users of the system. Based on the results, recommendations for dynamic pricing and incentive schemes are provided to positively influence mobility patterns and guide improved planning and management of public bicycle systems to increase uptake. PMID:24236127

  18. 一种电动车用锂电池剩余容量检测系统%A SOC detecting system for electric bicycle battery

    Institute of Scientific and Technical Information of China (English)

    赵庆河

    2012-01-01

    针对电动车应用中的需求,提出了一种电动车用锂电池剩余容量(SOC)检测的方法,并设计了一套SOC检测系统.该系统以AVR单片机为控制及计算核心、以ACS712为电流采集器,采用线性光耦隔离模拟电压信号,集合充放电电流对时间的积分和BP神经网络估算两种方法来测量电池SOC值.该系统具有成本低、安全可靠、计算准确等特点,适合在电动车上推广使用.%For electric bicycle application demand, a method of electric bicycle lithium battery state of charge (SOC) detection is proposed, and a SOC detection system is designed. The system is based on AVR MCU as the control and calculation core, used ACS712 as current collector. It uses a linearopto -isolator to insulate analog voltage signal. It measures SOC of the battery integrating two methods which are current integration to the time and BP neural network estimation. The system has the advantages of low cost, safe and reliable, accurate calculation and other characteristics. It is suitable for use in electric vehicles.

  19. 电动自行车调速系统的研究%Research on the Velocity Modulation System of Electrically Operated Bicycle

    Institute of Scientific and Technical Information of China (English)

    张俊强

    2012-01-01

    主要研究了电动自行车调速系统的实现方法、控制策略和电路原理。控制电路基于控制芯片8051单片机,通过转速传感器测量转速,通过八段数码管动态显示转速,并根据永磁无刷直流电动机的特性实施了脉宽PWM控制,在软硬件的配合下,实现了整个系统的设计要求。%The speed regulation performance of magnet brushless dc motor system controlled by single-chip microcomputer is good with small volume,energy saving,and suitable for small power work of electric bicycle.This paper mainly studies the electric bicycle speed regulation system,the realization method of control strategy and circuit principle.Control circuit is based on control chip 8051 single chip microcomputer,measures speed through the rotation speed sensor,displays the speed through the eight period of digital tube dynamic,and according to the characteristics of magnet brushless dc motor to implement the pulse width PWM control.With the cooperation of software and hardware,the system design requirements is achieved.

  20. Solar Hybrid Bicycle Control Strategy Research%太阳能混合动力自行车控制策略研究

    Institute of Scientific and Technical Information of China (English)

    游明琳; 俞红珊; 陈太祥; 龙关金; 王会武

    2014-01-01

    根据当今世界电动汽车发展的趋势,开展的一种新型混合动力电动自行车的研究,研究对象为太阳能电池/蓄电池混合动力自行车动力系统能源供电的控制策略,着重研究了太阳能电池/蓄电池选配和控制,把能源动力系统仿真模型匹配到原有的整车模型,获得太阳能电池/蓄电池混合动力自行车的控制策略。%I n this paper,according to the worldtrend of development of electric vehicles,a new hy-brid electric bicycle to carry out the research object,control strategy for solar cell / battery hybridelectric bicycle power system energy supply,focusing on the solar cell / battery selection and con-trol,the matching system simulation model of power energy to the original vehicle model the controlstrategy,the solar cell /battery hybrid bicyle.

  1. Core temperature response to immersed bicycle ergometer exercise at water temperatures of 21 degrees, 25 degrees, and 29 degrees C.

    Science.gov (United States)

    Israel, D J; Heydon, K M; Edlich, R F; Pozos, R S; Wittmers, L E

    1989-01-01

    A bicycle ergometer modified for aquatic exercise was used to determine the effects of immersion on core temperature during submaximal exercise at different water temperatures. An exercise intensity (60% of maximal oxygen consumption) and duration (30 minutes) considered appropriate for cardiovascular conditioning were used. These data will be useful in cardiovascular and leg-strengthening hydrotherapy programs. Rectal temperature, skin temperature, and a rating of thermal comfort were studied in five normal men (14.8% +/- 5.6% fat) during headout immersion at water temperatures of 21.1 degrees, 25.3 degrees, and 29.4 degrees C and exercise in air of 21.1 degrees C. Subjects were immersed for 30 minutes during static and exercise (63% +/- 0.6% maximal oxygen consumption) conditions. Data were collected every 5 minutes and analyzed by repeated measured analysis of variance. At water temperatures, rectal temperature fell from control during static immersion (p less than or equal to 0.05) and was lower than control at the end of the 30-minute recovery period (p less than or equal to 0.05). During exercise there was no change in rectal temperature at water temperatures of 21.1 degrees and 25.3 degrees C; however, rectal temperature rose at water temperatures of 29.4 degrees (p less than or equal to 0.05) and air 21.1 degrees C (p less than or equal to 0.05). At the end of recovery rectal temperature was lower than control at water temperatures 21.1 degrees C (p less than or equal to 0.05) and greater than control at water temperatures 29.4 degrees C (p less than or equal to 0.05). There was no change from control in rectal temperatures at water temperatures 25.3 degrees C and air at 21.1 degrees C. These results indicate that immersion in 25.3 degrees and 21.1 degrees C water effectively attenuates the rise in rectal temperature during exercise at 63% of maximal oxygen consumption, whereas immersion in 29.4 degrees C water does not. In addition, both skin and rectal

  2. Research on the campus bicycle management system based on The Internet of Things%基于物联网的校园自行车管理系统的研究

    Institute of Scientific and Technical Information of China (English)

    战国庆

    2012-01-01

    With the development of society,the number of bicycles is increasing on campus,which brings a lot of troubles to campus management.For loss of bicycles,misplacing bicycles,the technology of Internet of Things can solve this problem,also to enhance bicycles safety.By using RFID technology car keys,you can recharge recycling,which is green.Its internal smart chip make user authenticated automatically,park,lock your car and other automated management services.%随着社会的发展,校园自行车数量的不断增加,给校园管理带来了诸多烦恼。针对丢车、乱放车辆等现象,利用物联网技术,可以很好的解决此问题,同时也提升了车辆安全指数。系统车钥匙采用RFID(Radio Frequency Identification)技术,可以充值循环使用,绿色环保。其内部的智能芯片可自动完成用户鉴别、存车、锁车等自动化的管理服务。

  3. Ferrari Engines, Bicycle Brakes

    Science.gov (United States)

    Hallowell, Edward

    2012-01-01

    In this article, the author offers an advice to educators about how to help students with attention deficit hyperactivity disorder (ADHD) fulfill the potential of their powerful brains. It is a neurological fact that feeling safe opens up the brain, whereas feeling anxious and afraid clamps it down. So step one is to make sure all students feel as…

  4. BICYCLE TOURISM IN HUNGARY

    OpenAIRE

    Kormosne-Koch, Krisztina

    2013-01-01

    Side by side with the revaluation of a health-oriented lifestyle various kinds of axtive leisure activities and active tourism in particular have been gaining ground. Cycling, which is popular not only as a leisure time tourism activity but mainly within settlements, also as an environmentally-friendly and up to a certain extent, a highly practicable means of transport mainly in towns and cities in Western- Europe, has a privileged position within active tourism (SALAMIN, 2010). This article ...

  5. Bicycle Chain Shape Models

    DEFF Research Database (Denmark)

    Sommer, Stefan Horst; Tatu, Aditya Jayant; Chen, Chen;

    2009-01-01

    In this paper we introduce landmark-based preshapes which allow mixing of anatomical landmarks and pseudo-landmarks, constraining consecutive pseudo-landmarks to satisfy planar equidistance relations. This defines naturally a structure of Riemannian manifold on these preshapes, with a natural act...

  6. Building the Bicycle City

    DEFF Research Database (Denmark)

    2014-01-01

    and passengers stranded. This was the case in many Japanese cities after the fatal earthquake hit the country on March 11th2011. But more and more people are choosing to cycle to work. Should an earthquake hit Japan again (it will) and thousands being unable to go home by car or public transportations, cyclists...... will most likely be able to ride home. After the March 11th earthquake The Japan Cycling Association (JCA) has said that the number of cyclist in Tokyo might be five times as high today as it was before March 2011. But the worry is the safety of the new cyclists. Government statistics in 2010, showed...... that cyclists made up 16 % of road fatalities in Japan, compared to 3.7 % in France and 5.8 in UK. But what is needed? At first the topic has to be prioritized by politicians & planners and developed through innovation. According to the municipality of Copenhagen attention has to be drawn to four areas: • Urban...

  7. 基于恒流源的电动自行车续航器的设计%The Design of the Endurance for the Electric Bicycle Based on constant-current source

    Institute of Scientific and Technical Information of China (English)

    高宏洋

    2013-01-01

      To further make the mileage of electric bicycle driving and prevent battery less pressure causes the motor stops,the author invented Endurance for the Electric Bicycle Based on constant-current source, this Endurance based on the core of STC15F408AD,Real-time monitoring and prediction of the Holzer sensor of electric bicycle speed,mileage and so. In the electric bicycle battery voltage drops to 85% ,The Constant current output control speed so as to avoid the motor stop,in order to extend the bicycle travelled distance.Proven by the experiments,this invention is a reasonable design,easy to operate and can be spread for common use,it is much worth to popularize.%  针对使电动自行车行驶的里程更远并且防止因蓄电池欠压使电动机停转等问题,本文设计了基于恒流源的单片机电动自行车自动续航器,该续航器以STC15F408AD单片机为核心、通过霍尔传感器对电动自行车的速度、里程等进行实时监测和预报。在电动自行车蓄电池电压降至总电压85%时,通过恒流输出控制行驶速度从而避免了电动机停转,延长其行驶里程。通过实验证明,该设计合理、简单、通用,具有推广价值。

  8. Research on portable bicycle function instrument%便携式自行车功能仪的研究

    Institute of Scientific and Technical Information of China (English)

    董雨声; 马松浩; 汤庆威; 胡福年

    2015-01-01

    基于实现自行车使用过程中方便地了解速度里程等相关信息以及使用者的身体情况的目的, 采用以MSP430单片机为微处理器完成了便携式自行车功能仪测控系统设计方案,并完成系统的软硬件设计.系统实现温度测量、行驶里程及速度、血压及心率测量和实时显示于一身的便携式自行车功能仪系统. 系统的硬件部分主要设计各个测量参量传感器模块选择与设计以及与微处理器的接口设计,软件部分采用IAR for MSP430进行编程,实现对采集到的多个实时信号进行分析处理实现设计要求. 通过实际调试,系统可以稳定,快速得实现速度、里程、环境温度、使用者血压和心率等多个参量的实时测量与显示,并对超速,高血压进行报警,操作简单,使用方便,达到了设计要求.%Based on implementing bicycle use process easily understand the speed range and other relevant information as well as the body of the user, the purpose of using MSP430 single chip microcomputer as the microprocessor finished the portable bike function instrument measurement and control system design, and complete the hardware and software design of the system. System to realize the temperature measurement, the range and speed, blood pressure and heart rate measurement and real-time display of portable bike function instrument system. The hardware part of the system main design various measurement parameter selection and design sensor module and microprocessor interface design. Software part can be programmed using the IAR for MSP430 realize the collected multiple real-time signal analysis and processing to achieve the design requirements. Actual commissioning, the system can stabilize quickly get real-time measurement of multiple parameters of speed, mileage, temperature, blood pressure and heart rate and user display, and speeding, high blood pressure alarm, simple, easy to use, to the design requirements.

  9. 基于STC15单片机的自行车码表设计%Design of the Bicycle Speed Meter Based on STC15 MCU

    Institute of Scientific and Technical Information of China (English)

    杨凯; 周岳斌

    2015-01-01

    以S T C15系列单片机为主控芯片,采用S49E线性霍尔传感器,设计了一种可以实时显示骑行速度和里程的自行车码表,使用灵活、安装方便、可靠性高,配用新颖的O L ED显示,可以满足自行车运动的测速需求。%Adopting STC15 series single chip microcomputer as main control chip ,using S49E linear hall sensor ,a bicycle speed meter is designed ,which can real‐time display riding speed and mileage .It is capable of flexible use ,easy installation ,high relia‐bility ,and with novel OLED display ,can meet the speed measuring demand of cycle sport .

  10. 一种电动自行车控制器程序架构设计%Application Architecture Design of an Electric Bicycle Controller

    Institute of Scientific and Technical Information of China (English)

    胡伯生; 孙瑜

    2015-01-01

    介绍了一种电动自行车用BLDC电机控制器程序架构设计,利用STC15系列单片机独特的PCA模块实现对BLDC电机控制的每一个动作进行精确的设计.在电动自行车上的试验结果表明,按该程序结构设计的BLDC控制器工作稳定,有很好的应用价值.%This paper introduces a program structure design of brushless DC motor control er used on electric bicycle. This design al ows the brushless DC motor control er precisely control every movement of the motor basied on the unique PCA module of STC15 series microcontrol ers.Experiments show that,brushless DC motor works wel .

  11. Cytotoxic activity of new racemic and optically active N-phosphonoalkyl bicyclic β-amino acids against human malignant cell lines.

    Science.gov (United States)

    Todorov, Petar T; Wesselinova, Diana W; Pavlov, Nikola D; Martinez, Jean; Calmes, Monique; Naydenova, Emilia D

    2012-10-01

    The cytotoxic effects of novel racemic and optically active constrained N-phosphonoalkyl bicyclic β-amino acids were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT-29, MDA-MB-231, HepG2 and HeLa cell lines after 24 h treatment. The most sensitive cells were the HeLa cells at various concentrations of the four compounds tested. The aminophosphonate 3 exerted the most pronounced antiproliferative effect against the HeLa cells (inhibition of the cell vitality up to 70% at 0.5 mg/ml) and was not toxic to the normal Lep3 cells at lower concentration. Furthermore, the N-phosphonophenyl derivatives 1 and 2 displayed antiproliferative effect against mainly the MDA-MB-231 tumour cells at higher concentration.

  12. High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer

    International Nuclear Information System (INIS)

    Purpose: To establish high-resolution phase-contrast magnetic resonance imaging (PC-MRI) using a MRI compatible bicycle ergometer to quantify aortic and pulmonary blood flow during resting conditions and exercise. Materials and methods: In 20 healthy volunteers (mean age, 26.8 ± 5.0 years) high-resolution PC-MRI (mean temporal resolution, 7.4 ± 3.2 ms) was performed in the ascending aorta (AA) and main pulmonary artery (PA) during physical rest and three exercise stages: stage 1, no-load operation; stage 2, heart rate increase 40% compared to rest; stage 3, heart rate increase 80% compared to rest. Flow quantification in AA and PA included flow volume (FV), average velocity (AV), peak velocity (PV) and time to PV (TP). Results: In stage 1 only TP demonstrated a significant change. With progression to stage 2, all parameters altered significantly. Flow measurements during stage 3 evidenced further alterations only of AV and TP regarding both AA and PA. The deviation of the heart rate from the desired target value was significantly higher for stage 3 compared to stage 2, and 15% of the subjects did not reach the desired target heart rate of stage 3 at all. Conclusion: Flow quantification by high-resolution PC-MRI during exercise using a MRI compatible bicycle ergometer is feasible. Medium exercise stages are necessary and sufficient to demonstrate flow alterations in healthy volunteers. PC-MRI ergometry may give insights into aberrant hemodynamic conditions in patients with cardiovascular and pulmonary disease.

  13. High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Tim Frederik, E-mail: tim.weber@med.uni-heidelberg.de [Department of Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120 Heidelberg (Germany); Department of Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany); Tengg-Kobligk, Hendrik von, E-mail: hendrik.tengg-kobligk@med.uni-heidelberg.de [Department of Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120 Heidelberg (Germany); Department of Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany); Kopp-Schneider, Annette, E-mail: kopp@dkfz-heidelberg.de [Department of Biostatistics, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany); Ley-Zaporozhan, Julia, E-mail: julia.ley-zaporozhan@med.uni-heidelberg.de [Department of Pediatric Radiology, University Medical Center Heidelberg, INF 430, 69120 Heidelberg (Germany); Kauczor, Hans-Ulrich, E-mail: hans-ulrich.kauczor@med.uni-heidelberg.de [Department of Diagnostic and Interventional Radiology, University Medical Center Heidelberg, INF 110, 69120 Heidelberg (Germany); Ley, Sebastian, E-mail: sebastian.ley@med.uni.heidelberg.de [Department of Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany); Department of Pediatric Radiology, University Medical Center Heidelberg, INF 430, 69120 Heidelberg (Germany)

    2011-10-15

    Purpose: To establish high-resolution phase-contrast magnetic resonance imaging (PC-MRI) using a MRI compatible bicycle ergometer to quantify aortic and pulmonary blood flow during resting conditions and exercise. Materials and methods: In 20 healthy volunteers (mean age, 26.8 {+-} 5.0 years) high-resolution PC-MRI (mean temporal resolution, 7.4 {+-} 3.2 ms) was performed in the ascending aorta (AA) and main pulmonary artery (PA) during physical rest and three exercise stages: stage 1, no-load operation; stage 2, heart rate increase 40% compared to rest; stage 3, heart rate increase 80% compared to rest. Flow quantification in AA and PA included flow volume (FV), average velocity (AV), peak velocity (PV) and time to PV (TP). Results: In stage 1 only TP demonstrated a significant change. With progression to stage 2, all parameters altered significantly. Flow measurements during stage 3 evidenced further alterations only of AV and TP regarding both AA and PA. The deviation of the heart rate from the desired target value was significantly higher for stage 3 compared to stage 2, and 15% of the subjects did not reach the desired target heart rate of stage 3 at all. Conclusion: Flow quantification by high-resolution PC-MRI during exercise using a MRI compatible bicycle ergometer is feasible. Medium exercise stages are necessary and sufficient to demonstrate flow alterations in healthy volunteers. PC-MRI ergometry may give insights into aberrant hemodynamic conditions in patients with cardiovascular and pulmonary disease.

  14. A perspective of environmental protection to evaluate the national standard of electric bicycle%从环保角度看电动车新国标

    Institute of Scientific and Technical Information of China (English)

    俞思绮

    2012-01-01

    2012年9月1日起,《机动车运行安全托术条件》开始实施,时速在20公里以上、50公里以下,重量超过40公斤的电动车,将被作为轻便摩托车纳入机动车管理范畴。这一新国标的实施将会对人们的日常生活产生重大影响,也将改变很多人骑电动车出行这一环保行为。本文分析并论证了新国标将导致电动自行车使用减少,高耗能摩托车、汽车使用增加,最终导致大气污染加剧、人们生活水平降低。%The technical reguration of the Safety Technical Conditions of the Operation of Motor Vehicles begins to come into effect on September l, 2012, which regulates that those electr)c bicycles whose maximum speed is 20 to 50 km/h or weight ie beyond 40 Kg will be resarded as light and be included to the motor vehicle management category. The implement of it will have a significant influence on people's daily lives and change a large number of citizens' environmental habit of going out by electric bicycle. The article analyzes and demonstrates that the new regulation will result in reduction of the usage of electric bicydes and more usage of energy--intensive motorcycles and cars. thus aggravating air pollution and reducing people's living standard.

  15. A Survey on Subway & Foldable Bicycle Commuting: A Case Study in Nanjing%地铁+折叠自行车通勤出行调查——以南京市为例

    Institute of Scientific and Technical Information of China (English)

    梁晶; 石飞; 祁毅; 陈曦

    2011-01-01

    为研究地铁+折叠自行车通勤方式的效果,以南京地铁为例对使用折叠自行车的乘客和普通乘客进行了现场调查和问卷调查.分析相关数据发现:地铁+折叠自行车的通勤方式在南京已获得了较好的实践及市民的广泛认可;与私人小汽车、公共汽车、自行车、地铁+步行等交通方式相比,更加节约出行时间和出行成本,也更加低碳.随着地铁线网的加密,地铁+折叠自行车通勤方式的服务范围可达主城区总面积的92%.为更好地推广这种健康环保的出行方式、鼓励更多的人使用公共交通,从城市及交通规划、设施配置、宣传引导三个层面提出了改进建议.%In order to study the effect of subway plus foldable bicycle commuting, a survey was conducted on subway passengers with and without foldable bicycle through questionnaires and interviews in Nanjing city subway. The results show that subway plus foldable bicycle has been recognized and accepted as a practical commuting travel mode by citizens. Comparing with other travel modes such as private car, bus, bicycle, and subway & walking, the combination of subway and foldable bicycle can reduce travel time and cost, and decrease carbon emission. With the subway network expansion, the subway & bicycle commuting travel can cover 92% Nanjing main urban areas. To better promote this health and environmental friendly travel mode, improvements in urban planning, transportation facility development and public policy are proposed by the paper to encourage high utilization of public transportation.

  16. 简洁高效的双齿杆双飞轮自行车的设计%Concise and Efficient Design of Bicycle wi th Dou ble Gear Lever and Double Flywheel

    Institute of Scientific and Technical Information of China (English)

    刘国林; 刘淼

    2014-01-01

    采用双齿杆双飞轮动力传动结构,设计了一款双齿杆双飞轮自行车,设计的自行车节省了制作材料和成本、减少了摩擦环节且更省力,制造、安装、维修和使用更简便,是一款很实用的新型高效自行车。%Dynamic structure of the double gear lever and double flywheel are adopted to design a bicycle with double gear lever and double flywheel .This bicycle is of practical use ,highly efficiency ,which can save mate-rials and cost,reduce friction,and provide convenience for production,installation,maintenance and use.

  17. 自行车碟刹制动距离测试系统的设计与实现%Design and implementation of bicycle disc braking distance test system

    Institute of Scientific and Technical Information of China (English)

    陈梦群; 杨成忠

    2012-01-01

    随着碟刹的使用越来越普及,刹车的可靠性测试显得尤为重要,而国内市场上尚没有针对碟刹的测试系统.针对这一问题,设计了一套自行车碟刹制动距离测试系统.首先建立了自行车的刹车模拟装置,然后在模拟装置上安装了拉力传感器和速度传感器对其进行实时监测,传感器信号由数据采集卡采集并上传至上位机,上位机软件分析数据后下发命令控制模拟装置的刹车过程,并实时显示拉力值、速度值和制动距离等.通过多次制动距离测试,求平均值,确定了碟刹的制动距离,最后进行了试验验证.研究结果表明,该测试系统能够较准确地测量出自行车的制动距离,并且性能稳定,简单易操作,实用性强,具有良好的实际应用价值.%As the bicycle disc brake is getting more and more popular,the reliability testing is very important. But in the domestic market, there is no test system for the disc brake. Aiming at this problem,a system was designed to test the braking distance of the bicycle disc brake. The bicycle simulator was firstly created to simulate bicycle braking. Then a tension sensor and a speed sensor were installed on the braking simulator. The tension sensor was used to indirectly measure the power of gripping on the handlebar when the bicycle simulator was braking. The speed sensor was used to measure the speed of the inertial disc throughout the braking process. The signals of the two sensors were collected by the data acquisition card. The data of the sensors from the data acquisition card was gotten and analyzed, the commands were sent to control of the braking process, the data was real-time displayed,including tension value, velocity,the braking distance and so on. The braking distance of a bicycle disc brake was determined by the average of multiple test results. Finally the verification experiment was done in a factory producing Bicycle disc brakes. The results indicate that the

  18. A Setup & Design of Wuyi Mountain Chongyangxi Bicycle Tour Lane System%武夷山崇阳溪自行车游览道系统的设置与设计

    Institute of Scientific and Technical Information of China (English)

    王磊

    2013-01-01

      With the engineering background of Wuyi Mountain Chongyangxi bicycle tour lane system design, a complete framework of bicycle tour lane system is built in this paper. Meanwhile, the design content, principle and key point of every sub-system are presented and summarized.%  以武夷山崇阳溪自行车游览道系统设计为工程背景,建立自行车游览道系统的完整框架。同时,就每个子系统的设计内容、原则和要点进行阐述和小结。

  19. The Application of TRIZ Theory in the Picnic Buffet Bicycle Design%TRIZ 理论在野餐自助自行车设计中的应用

    Institute of Scientific and Technical Information of China (English)

    辛明远; 张世豪; 张淑颖

    2015-01-01

    According to the application requirements of outdoor bicycle, TRIZ tools such as problem de-scription, technical contradiction analysis are used.According to TRIZ the general path to solve the problem, the applications of comprehensive analysis of invention principles are analyzed.The final solution is formed. Picnic buffet the conceptual design of bicycle is given.%从多人户外自行车的应用需求出发,使用问题描述、技术矛盾分析等TRIZ工具,按照TRIZ解决问题的一般路径,综合分析发明原理应用的可行性,形成最终解决方案,最后给出野餐自助自行车的概念设计。

  20. Optimal Design of the Reverse Logistics Network for Wastes Electric Bicycle Battery%电动自行车电池逆向物流网络优化设计研究

    Institute of Scientific and Technical Information of China (English)

    陈红梅; 宋志伟

    2014-01-01

    To deal with the wastes electric bicycle battery recycling network is not perfect and battery recycling process is not scientific problems ,combined with the electric bicycle logistics in our country ,the enterprise setting up wastes electric bicycle battery reverse logistics network based on its forward logistics network was established in order to minimize the total cost of establishing the wastes electric bicycle battery reverse logistics network.The model is a mixed integer programming model ,and to solve it by LINGO 11.0 sofeware.The number and position of recycling centers and processing centers in the network can be decided.Finally,through effective examples verify the model.%针对电动自行车电池回收网络不完善,电池回收处理流程不科学的问题,以我国现有电动自行车销售网点为基础,以企业构建电动自行车电池逆向物流网络的总成本最小为目标,建立电动自行车电池逆向物流的非线性混合整数规划网络模型,通过LINGO 11.0软件对该模型进行求解,以确定废旧电池回收中心、处理中心数量和位置。最后,通过算例验证模型的有效性。