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Sample records for bicc1 impairs tubulomorphogenesis

  1. Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones.

    Science.gov (United States)

    Davidson, S; Shanley, L; Cowie, P; Lear, M; McGuffin, P; Quinn, J P; Barrett, P; MacKenzie, A

    2016-08-01

    The Bicaudal C Homolog 1 (BICC1) gene, which encodes an RNA binding protein, has been identified by genome wide association studies (GWAS) as a candidate gene associated with major depressive disorder (MDD). We explored the hypothesis that MDD associated single-nucleotide polymorphisms (SNPs) affected the ability of cis-regulatory elements within intron 3 of the BICC1 gene to modulate the activity of the BICC1 promoter region. We initially established that the BICC1 promoter drove BICC1 mRNA expression in amygdala, hippocampus and hypothalamus. Intriguingly, we provide evidence that MDD associated polymorphisms alter the ability of the BICC1 promoter to respond to PKA signalling within amygdala neurones. Considering the known role of amygdala PKA pathways in fear learning and mood these observations suggest a possible mechanism through which allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders. Our findings also suggest a novel direction for the identification of novel drug targets and the design of future personalised therapeutics.The Pharmacogenomics Journal advance online publication, 6 October 2015; doi:10.1038/tpj.2015.62. PMID:26440730

  2. Impaired Driving

    Science.gov (United States)

    ... help prevent injuries and deaths from alcohol-impaired driving. The Problem Risk Factors BAC Effects Prevention Additional Resources How big is the problem? In 2014, 9,967 people were killed in alcohol-impaired driving crashes, accounting for nearly one-third (31%) of ...

  3. Visual Impairment

    Science.gov (United States)

    ... poorly lit spaces, and colors that seem faded. Diabetic retinopathy (pronounced: reh-ton-AH-pa-thee) occurs when ... that is likely to cause visual impairment, many treatments are available. Options may include eyeglasses, contact lenses, ...

  4. Hearing Impairment

    Science.gov (United States)

    ... hearing loss is present at birth. Acquired hearing loss happens later in life — during childhood, the teen years, or in adulthood — ... for your ears to avoid a permanent hearing loss. See your doctor right away ... basis. What's Life Like for People Who Are Hearing Impaired? For ...

  5. All Vision Impairment

    Science.gov (United States)

    ... Cases of Vision Impairment (in thousands) by Age, Gender, and Race/Ethnicity Table for 2010 U.S. Prevalent ... Cases of Vision Impairment (in thousands) by Age, Gender, and Race/Ethnicity Table for 2000 U.S. Prevalent ...

  6. Speech impairment (adult)

    Science.gov (United States)

    ... impairment; Impairment of speech; Inability to speak; Aphasia; Dysarthria; Slurred speech; Dysphonia voice disorders ... in others the condition does not get better. DYSARTHRIA With dysarthria, the person has ongoing difficulty expressing ...

  7. Mild Cognitive Impairment

    Science.gov (United States)

    ... Research Portfolio (IADRP) AMP-AD Detecting Cognitive Impairment Database ... Mild cognitive impairment (MCI) is a condition in which people have more memory or other thinking problems than normal for their ...

  8. Visual impairment in the hearing impaired students

    Directory of Open Access Journals (Sweden)

    Gogate Parikshit

    2009-01-01

    Full Text Available Background : Ocular problems are more common in children with hearing problems than in normal children. Neglected visual impairment could aggravate educational and social disability. Aim : To detect and treat visual impairment, if any, in hearing-impaired children. Setting and Design : Observational, clinical case series of hearing-impaired children in schools providing special education. Materials and Methods : Hearing-impaired children in selected schools underwent detailed visual acuity testing, refraction, external ocular examination and fundoscopy. Ocular motility testing was also performed. Teachers were sensitized and trained to help in the assessment of visual acuity using Snellen′s E charts. Refractive errors and squint were treated as per standard practice. Statistical Analysis : Excel software was used for data entry and SSPS for analysis. Results : The study involved 901 hearing-impaired students between four and 21 years of age, from 14 special education schools. A quarter of them (216/901, 24% had ocular problems. Refractive errors were the most common morbidity 167(18.5%, but only 10 children were using appropriate spectacle correction at presentation. Fifty children had visual acuity less than 20/80 at presentation; after providing refractive correction, this number reduced to three children, all of whom were provided low-vision aids. Other common conditions included strabismus in 12 (1.3% children, and retinal pigmentary dystrophy in five (0.6% children. Conclusion : Ocular problems are common in hearing-impaired children. Screening for ocular problems should be made mandatory in hearing-impaired children, as they use their visual sense to compensate for the poor auditory sense.

  9. Hypertension and cognitive impairment

    Directory of Open Access Journals (Sweden)

    Su-hang SHANG

    2015-08-01

    Full Text Available As a leading risk factor for stroke, hypertension is also an important risk factor for cognitive impairment. Midlife hypertension doubles the risk of dementia later in life and accelerates the progression of dementia, but the correlation between late-life blood pressure and cognitive impairment is still unclear. Beside blood pressure, the effect of pulse pressure, blood pressure variability and circadian rhythm of blood pressure on cognition is currently attracting more and more attention. Hypertension induces alterations in cerebrovascular structure and functions, which lead to brain lesions including cerebral atrophy, stroke, lacunar infarcts, diffuse white matter damage, microinfarct and microhemorrhage, resuling in cognitive impairment. Hypertension also impairs the metabolism and transfer of amyloid-β protein (Aβ, thus accelerates cognitive impairment. Individualized therapy, focusing on characteristics of hypertensive patients, may be a good choice for prevention and treatment of cognitive impairment. DOI: 10.3969/j.issn.1672-6731.2015.08.004

  10. Impairments to Vision

    Science.gov (United States)

    ... an external Non-Government web site. Impairments to Vision Normal Vision Diabetic Retinopathy Age-related Macular Degeneration In this ... pictures, fixate on the nose to simulate the vision loss. In diabetic retinopathy, the blood vessels in ...

  11. Aids for visual impairment.

    OpenAIRE

    Dudley, N. J.

    1990-01-01

    This article provides only a flavour of the type and range of aids available to the visually impaired person. Many other aids for leisure, learning, and daily living are illustrated in the RNIB equipment and games catalogue.

  12. Kids' Quest: Vision Impairment

    Science.gov (United States)

    ... and neighborhood . Step 8: Now see if your attitudes have changed. Take the Fact Checkup again. ... impairment also have at least one other developmental disability, such as intellectual disabilities, cerebral palsy, hearing loss, ...

  13. Speech impairment (adult)

    Science.gov (United States)

    ... ALS or Lou Gehrig disease), cerebral palsy, myasthenia gravis, or multiple sclerosis (MS) Facial trauma Facial weakness, ... provider will likely ask about the speech impairment. Questions may include when the problem developed, whether there ...

  14. What determines goodwill impairment?

    OpenAIRE

    Verriest, Arnt; Gaeremynck, Ann

    2009-01-01

    This study investigates determinants of goodwill impairment decisions and their disclosure quality. Under IAS36 goodwill is subject to an annual impairment test in which the carrying amount of goodwill is not allowed to exceed the recoverable amount. However, valuing this recoverable amount is subject to substantial managerial discretion. Therefore, we predict that ownership concentration, corporate governance quality and firm performance provide incentives for managers to engage in goodwill ...

  15. Vascular cognitive impairment

    Directory of Open Access Journals (Sweden)

    N.V. Vakhnina

    2014-05-01

    Full Text Available Vascular pathology of the brain is the second most common cause of cognitive impairment after Alzheimer's disease. The article describes the modern concepts of etiology, pathogenetic mechanisms, clinical features and approaches to diagnosis and therapy of vascular cognitive impairment (VCI. Cerebrovascular accident, chronic cerebral circulatory insufficiency and their combination, sometimes in combination with a concomitant neurodegenerative process, are shown to be the major types of brain lesions leading to VCI. The clinical presentation of VCI is characterized by the neuropsychological status dominated by impairment of the executive frontal functions (planning, control, attention in combination with focal neurological symptoms. The diagnosis is based on comparing of the revealed neuropsychological and neurological features with neuroimaging data. Neurometabolic, acetylcholinergic, glutamatergic, and other vasoactive drugs and non-pharmacological methods are widely used to treat VCI. 

  16. Visual Impairment, Including Blindness

    Science.gov (United States)

    ... top Adapting the Environment Making adaptations to the environment where a child with a visual impairment lives, works, or plays ... can consult, depending on your role in the child’s life, are: Family Connect ... to the Physical Environment: Setting up a Classroom for Students with Visual ...

  17. Specific Language Impairment

    Science.gov (United States)

    ... to distinguish between children who are struggling to learn a new language and children with true language impairments. After studying a large group of Hispanic children who speak English as a second language, NIDCD-funded researchers have developed a dual ...

  18. Neurological Impairment: Nomenclature and Consequences.

    Science.gov (United States)

    Spears, Catherine E.; Weber, Robert E.

    Neurological impairment as discussed includes a range of disabilities referred to as neurological impairment: minimal brain dysfunction/damage, developmental disability, perceptual handicap, learning disability, hyperkinetic behavioral syndrome, and others. Defined are causes of neurological impairment and methods of diagnosis. Symptoms…

  19. Impaired Consciousness in Epilepsy

    OpenAIRE

    Blumenfeld, Hal

    2012-01-01

    Consciousness is essential to normal human life. In epileptic seizures consciousness is often transiently lost making it impossible for the individual to experience or respond. This has huge consequences for safety, productivity, emotional health and quality of life. To prevent impaired consciousness in epilepsy it is necessary to understand the mechanisms leading to brain dysfunction during seizures. Normally the “consciousness system”—a specialized set of cortical-subcortical structures—mai...

  20. Cryotherapy impairs proprioception function?

    OpenAIRE

    Cordeiro, Nuno; Henriques, Sara

    2014-01-01

    INTRODUCTION: Cryotherapy application over a joint causes a nerve conduction velocity decrease and proprioceptive changes. OBJECTIVE: This study aims to determine if cryotherapy impairs proprioception acuity. METHODS: Proprioception was assessed by joint position sense (JPS), measured with an isokinetic dynamometer Biodex System 3, in twenty one females on experimental group, before 15 minutes cryotherapy (T0) and immediately after (T1). A control group (n=20) performed also the JPS...

  1. The visually impaired child.

    Science.gov (United States)

    Thompson, Lisa; Kaufman, Lawrence M

    2003-02-01

    This article discusses the causes of childhood blindness and how the primary care provider may begin the appropriate steps toward diagnosing and managing the visually impaired child. Community resources (see Box 3) and low-vision programs in schools should be used so that parents do not need to reinvent strategies to raise a blind child. Worldwide, childhood blindness, which places is a tremendous burden on families and communities of the third world, is mostly preventable with improved hygiene, diet, and immunization. PMID:12713115

  2. Mild cognitive impairment

    Directory of Open Access Journals (Sweden)

    Pavlović Dragan M.

    2009-01-01

    Full Text Available Mild cognitive impairment (MCI is a syndrome that spans the area between normal ageing and dementia. It is classified into amnestic and non-amnestic types, both with two subtypes: single domain and multiple domains. Prevalence of MCI depends on criteria and population and can vary from 0.1 to 42% persons of older age. In contrast to dementia, cognitive deterioration is less severe and activities of daily living are preserved. Most impaired higher cognitive functions in MCI are memory, executive functions, language, visuospatial functions, attention etc. Also there are depression, apathy or psychomotor agitation, and signs of psychosis. Aetiology of MCI is multiple, mostly neurodegenerative, vascular, psychiatric, internistic, neurological, traumatic and iatrogenic. Persons with amnestic MCI are at a higher risk of converting to Alzheimer's disease, while those with a single non-memory domain are at risk of developing frontotemporal dementia. Some MCI patients also progress to other dementia types, vascular among others. In contrast, some patients have a stationary course, some improve, while others even normalize. Every suspicion of MCI warrants a detailed clinical exploration to discover underlying aetiology, laboratory analyses, neuroimaging methods and some cases require a detailed neuropsychological assessment. At the present time there is no efficacious therapy for cognitive decline in MCI or the one that could postpone conversion to dementia. The treatment of curable causes, application of preventive measures and risk factor control are reasonable measures in the absence of specific therapy.

  3. Specific language impairment.

    Science.gov (United States)

    Kamhi, Alan G; Clark, Mary Kristen

    2013-01-01

    The acquisition of language is one of the most important achievements in young children, in part because most children appear to acquire language with little effort. Some children are not so fortunate, however. There is a large group of children who also have difficulty learning language, but do not have obvious neurological, cognitive, sensory, emotional, or environmental deficits. Clinicians often refer to these children as language disordered or language impaired. Researchers tend to refer to these children as specific language impaired (SLI). Children with SLI have intrigued researchers for many years because there is no obvious reason for their language learning difficulties. SLI has been found to be an enduring condition that begins in early childhood and often persists into adolescence and adulthood. The language problems of children with SLI are not limited to spoken language; they also affect reading and writing and thus much of academic learning. Knowledge of the characteristics of SLI should aid physicians, pediatricians, and early childhood specialists to identify these children during the preschool years and ensure that they receive appropriate services. With high-quality language intervention and literacy instruction, most children with SLI should be able to perform and function adequately in school and beyond. PMID:23622167

  4. Dimethylfumarate Impairs Neutrophil Functions.

    Science.gov (United States)

    Müller, Susen; Behnen, Martina; Bieber, Katja; Möller, Sonja; Hellberg, Lars; Witte, Mareike; Hänsel, Martin; Zillikens, Detlef; Solbach, Werner; Laskay, Tamás; Ludwig, Ralf J

    2016-01-01

    Host defense against pathogens relies on neutrophil activation. Inadequate neutrophil activation is often associated with chronic inflammatory diseases. Neutrophils also constitute a significant portion of infiltrating cells in chronic inflammatory diseases, for example, psoriasis and multiple sclerosis. Fumarates improve the latter diseases, which so far has been attributed to the effects on lymphocytes and dendritic cells. Here, we focused on the effects of dimethylfumarate (DMF) on neutrophils. In vitro, DMF inhibited neutrophil activation, including changes in surface marker expression, reactive oxygen species production, formation of neutrophil extracellular traps, and migration. Phagocytic ability and autoantibody-induced, neutrophil-dependent tissue injury ex vivo was also impaired by DMF. Regarding the mode of action, DMF modulates-in a stimulus-dependent manner-neutrophil activation using the phosphoinositide 3-kinase/Akt-p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 pathways. For in vivo validation, mouse models of epidermolysis bullosa acquisita, an organ-specific autoimmune disease caused by autoantibodies to type VII collagen, were employed. In the presence of DMF, blistering induced by injection of anti-type VII collagen antibodies into mice was significantly impaired. DMF treatment of mice with clinically already-manifested epidermolysis bullosa acquisita led to disease improvement. Collectively, we demonstrate a profound inhibitory activity of DMF on neutrophil functions. These findings encourage wider use of DMF in patients with neutrophil-mediated diseases. PMID:26763431

  5. Impaired Verb Fluency: A Sign of Mild Cognitive Impairment

    Science.gov (United States)

    Ostberg, Per; Fernaeus, Sven-Erik; Hellstrom, Ake; Bogdanovic, Nenad; Wahlund, Lars Olof

    2005-01-01

    We assessed verb fluency vs. noun and letter-based fluency in 199 subjects referred for cognitive complaints including Subjective Cognitive Impairment, Mild Cognitive Impairment, and Alzheimer's disease. ANCOVAs and factor analyses identified verb, noun, and letter-based fluency as distinct tasks. Verb fluency performance in Mild Cognitive…

  6. Astrocytes Underlie Neuroinflammatory Memory Impairment

    OpenAIRE

    Osso, LA; Chan, JR

    2015-01-01

    © 2015 Elsevier Inc. All rights reserved. Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.

  7. Management of impaired fracture healing: Historical aspects

    OpenAIRE

    Gajdobranski Đorđe; Micić Ivan; Mitković Milorad B.; Mladenović Desimir; Milankov Miroslav

    2005-01-01

    Introduction Establishing continuity of long bones in cases of impaired bone healing and pseudo-arthrosis is one of the most complex problems in orthopedics. Impaired bone healing The problem of impaired fracture healing is not new. As in other areas of human life, the roots of modern treatment of impaired bone healing lie in ancient medicine. A relatively high percentage of impaired bone healing, as well as unsatisfactory results of standard therapies of impaired bone healing and pseudoarthr...

  8. [Cognitive Impairment in Multiple Sclerosis].

    Science.gov (United States)

    Niino, Masaaki; Miyazaki, Yusei

    2016-04-01

    While cognitive impairment is a major symptom of multiple sclerosis (MS), it is commonly overlooked. This may be explained by the fact that it is difficult to evaluate cognitive function in patients with MS using screening batteries for the detection of dementia such as the mini-mental state examination. Further more, cognitive impairment in MS typically involves domain-specific deficits such as imparement of sustained attention and information processing speed rather than global cognitive decline. Cognitive impairment may influence the daily living and social lines of affected patients. This review discusses the characteristics of cognitive impairment, appropreate tests to evaluate its symptoms, and the current status of clinical trials for the treatment of MS. PMID:27056855

  9. [Drug-induced Cognitive Impairment].

    Science.gov (United States)

    Shinohara, Moeko; Yamada, Masahito

    2016-04-01

    Elderly people are more likely than young people to develop cognitive impairments associated with medication use. One of the reasons for this is that renal and liver functions are often impaired in elderly people. Dementia and delirium (an acute confused state) are known to be associated with drug toxicity. Anticholinergic medications are common causes of both acute and chronic cognitive impairment. Psychoactive drugs, antidepressants and anticonvulsants can cause dementia and delirium. In addition, non-psychoactive drugs such as histamine H2 receptor antagonists, corticosteroids, NSAIDs (nonsteroidal anti-inflammatory agent), and cardiac medications, may cause acute or chronic cognitive impairment. Early diagnosis and withdrawal of the offending agent are essential for the prevention of drug-induced dementia and delirium. PMID:27056860

  10. ENVIRONMENTAL INJUSTICE AND MOBILITY IMPAIRMENT

    Directory of Open Access Journals (Sweden)

    Michael Cahill

    2013-06-01

    Full Text Available The study of mobility is a growth area in the social sciences.  The car system (automobility has had as one of its consequences reduced opportunities for mobility impaired people to walk in their local environment. Immobility has resulted for many people with disabilities. Despite the promotion of physical activity by public health guidance local environments are often hazardous for mobility impaired people.  In particular, there is a problem with cars parking on pavements and pavement cycling.

  11. Emotional impairment in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    CHEN Hai-bo

    2013-08-01

    Full Text Available Emotional impairment is the common complication of Parkinson's disease (PD. Depression, anxiety and apathy affect the quality of life and the prognosis of PD patients. Neuropsychological and neuroimaging studies of emotional impairment in PD patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways, but the specific mechanism needs further study. In this review we discuss the clinical manifestation, possible pathological mechanism, diagnosis and treatment in PD patients.

  12. Assessing functional impairment in individuals with mild cognitive impairment

    Directory of Open Access Journals (Sweden)

    Patrícia Belchior

    2016-04-01

    Full Text Available To date, there is no consensus on how to assess functional impairment in individuals with mild cognitive impairment (MCI, and this lack of consensus is reflected in the clinical practice. Since the criterion used in the literature is very vague, clinicians are still left without much guidance in this area. Thus, the main goal of this study was to examine how functional impairment in individuals with MCI has been assessed in the literature. An electronic database search strategy was developed in consultation with an experienced librarian. Four databases (CINAHL, PsycINFO, PubMed, and MEDLINE were searched from 2000 to May 2014 to provide a comprehensive coverage of the literature. The literature search yielded 14 tools that assessed functional impairment in MCI. Among those, nine tools were performance-based measures in which participants were observed while executing a task in a simulated environment using real life material. In terms of questionnaires (either informant- or self-reports, five tools were found. Different functional domains have been assessed in each tool. According to this review, the characteristics of the instruments used in the literature to assess functional impairment in individuals with MCI vary greatly. Nonetheless, results of this study allow clinicians to make better-informed decisions when choosing a functional assessment for this population.

  13. Patterns of Semantic Memory Impairment in Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Sven Joubert

    2008-01-01

    Full Text Available Although the semantic memory impairment has been largely documented in Alzheimer's disease, little is known about semantic memory in the preclinical phase of the disease (Mild Cognitive Impairment. The purpose of this study was to document the nature of semantic breakdown using a battery of tests assessing different aspects of conceptual knowledge: knowledge about common objects, famous people and famous public events. Results indicate that all domains of semantic memory were impaired in MCI individuals but knowledge about famous people and famous events was affected to a greater extent than knowledge about objects. This pattern of results suggests that conceptual entities with distinctive and unique properties may be more prone to semantic breakdown in MCI. In summary, results of this study support the view that genuine semantic deficits are present in MCI. It could be useful to investigate the etiological outcome of patients failing or succeeding at such tests.

  14. Language Impairment and Generative Analysis

    Directory of Open Access Journals (Sweden)

    Andrej Stopar

    2004-12-01

    Full Text Available This article deals with different types of language impairment from the perspective of generative grammar. The paper focuses on syntactic deficiencies observed in aphasic and SLI (specific language impairment patients. We show that the observed ungrammatical structures do not appear in a random fashion but can be predicted by that theory of universal sentence structure which posits a strict hierarchy of its constituent parts. The article shows that while the hierarchically lower elements remain unaffected, the higher positions in the hierarchy show various degrees of syntactic impairment. The paper supports the implementation of recent developments in the field of generative grammar with the intention of encouraging further theoretical, experimental and therapeutic research in the field.

  15. Driver Compensation: Impairment or Improvement?

    Science.gov (United States)

    Young, Richard A

    2015-12-01

    Strayer et al.'s conclusion that their "cognitive distraction scale" for auditory-vocal tasks indicates "significant impairments to driving" is not supported by their data. Additional analysis demonstrates that slower brake reaction times during auditory-vocal tasks were fully compensated for by longer following distances to the lead car. Naturalistic driving data demonstrate that cellular conversation decreases crash risk, the opposite of the article's assumption. Hence, the scale's internal and external validities for indicating driving impairment are highly questionable. PMID:26534851

  16. Oceanography for the Visually Impaired

    Science.gov (United States)

    Fraser, Kate

    2008-01-01

    Amy Bower is a physical oceanographer and senior scientist at the Woods Hole Oceanographic Institution (WHOI) in Woods Hole, Massachusetts--she has also been legally blind for 14 years. Through her partnership with the Perkins School for the Blind in Watertown, Massachusetts, the oldest K-12 school for the visually impaired in the United States,…

  17. Language Impairment in Autistic Children.

    Science.gov (United States)

    Deaton, Ann Virginia

    Discussed is the language impairment of children with infantile autism. The speech patterns of autistic children, including echolalia, pronomial reversal, silent language, and voice imitation, are described. The clinical picture of the autistic child is compared to that of children with such other disorders as deafness, retardation, and…

  18. Language Impairment in Cerebellar Ataxia

    NARCIS (Netherlands)

    van Gaalen, Judith; de Swart, Bert J. M.; Oostveen, Judith; Knuijt, Simone; van de Warrenburg, Bart P. C.; Kremer, Berry (H. ) P. H.

    2014-01-01

    Background: Several studies have suggested that language impairment can be observed in patients with cerebellar pathology. The aim of this study was to investigate language performance in patients with spinocerebellar ataxia type 6 (SCA6). Methods: We assessed speech and language in 29 SCA6 patients

  19. Cognitive Impairment in Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Farnaz Etesam

    2014-01-01

    Full Text Available Cognitive impairment can emerge in the earliest phases of multiple sclerosis. It strongly impacts different aspects of Multiple Sclerosis (MS patients' lives, like employment, social relationships and the overall quality of life; thus, its on-time recognition and treatment is mandatory. This paper discusses issues, diagnostic methods and treatment options for cognitive dysfunctions in MS. This paper is a descriptive review of the related studies in the recent 10 years, performing a keyword search in the main databases4T. Cognitive impairment mostly involves aspects of information processing, memory and executive functioning in MS. Neuropsychological tests like MACFIMS and BRB-N are recommended for its assessment. Still, there is no fully efficient treatment for cognitive impairment. Researchers have shown some positive effects, using disease-modifying therapies and cognitive rehabilitation. Depression, pain, fatigue and other factors influencing cognitive functions must be paid attention to4T. Recognizing cognitive impairment as a major symptom for MS, makes studying this subject one of the priorities in dealing with the disease. Therefore, a consecutive research for identification and management of this part of quality of life in MS patients is obligatory4T.4T

  20. Cognitive impairments may mimic delusions.

    Science.gov (United States)

    Eterović, Marija; Kozarić-Kovačić, Dragica

    2015-12-01

    Delusions are often recognized as key to the concept of psychosis. What is delusion is one of the basic questions of psychopathology. The common denominator of definitions of delusions is the divergence between the strong conviction in the delusional belief and superior evidences to the contrary which are continually ignored. An implicit, sustainably unspoken assumption is that the person with delusional belief has cognitive capacities to process the (counter-)arguments relevant to their delusion. However, individual's cognitive capacities are not being emphasized when delusions are evaluated. Moreover, the impact of cognitive decline on formation of delusions is neglected, both in theory and practice. We elaborate that cognitive deficits may facilitate, oppose, or mimic delusions. We focus on the last, which can lead to diagnosing as delusion what could be explained by cognitive decline and better called pseudo-delusion. The risk is significant when cognition is impaired, as in demented people; an issue which has not yet been debated. True delusions are incompatible with person's cognitive capacities, i.e., if we take into account person's cognitive status, we still cannot understand how the person holds the strange belief with an extraordinary conviction. Pseudo-delusions would be beliefs, thoughts or judgments that at first seem delusional (they are false, subculturally atypical beliefs that are strongly maintained in the face of counterargument), but lose the essence of delusions after we take cognitive impairment into account. Pseudo-delusions could actually be explained or understood by person's cognitive impairments, they "fit into" them. The reported reality-based contents of delusions in the elderly, poor response to antipsychotics and lack of association with early or family history of psychiatric disorders could in part be accounted for by the bias of misdiagnosing the cognitive impairment as the delusion. Not recognizing that the cognitive impairment

  1. Cognitive impairments in cerebrovascular disease

    Directory of Open Access Journals (Sweden)

    A. Yu. Emelin

    2014-12-01

    Full Text Available Cerebrovascular diseases belong to a group of the major causes of cognitive impairments, in the elderly in particular. The paper presents current ideas on the etiology and pathogenesis of vascular cognitive impairments (VCI. The etiological factors of VCI may be divided into genetic, sociodemographic, and common risk factors for vascular and other diseases. The pathogenesis of VCI is multifactorial; cognitive function decrement results from brain damage due to cerebral circulatory disorders. Damage to the deep white matter portions and basal ganglions plays a leading role in the development of cognitive deficit in cerebral circulatory insufficiency, disrupting the connections between the frontal lobes and subcortical structures (a dissociation phenomenon. Regulatory functions are impaired; instability of volitional attention develops; the speed of thinking processes and the performance of professional and everyday skills are suffered, mnestic functions being impaired to a lesser extent. Impairments in other higher cortical functions, such as speech, gnosis, praxis, thinking, generally occur in the later stages of cognitive deficit. The comprehensive approach to examining patients with cognitive dysfunctions, which encompasses physical examination with a mandatory evaluation of neurological symptoms, neuropsychological testing, laboratory studies, instrumental diagnostic methods, and structural and functional neuroimaging techniques, are most justified now. VCI therapy is a challenging task requiring the specific features of different types of cognitive deficit to be analyzed, by providing a rationale for the choice of medications. Therapeutic effectiveness may be enhanced by rational combined multimodal therapy, by keeping in mind a variety of factors for the pathogenesis of VCI.

  2. Impaired glycemia increases disease progression in mild cognitive impairment

    OpenAIRE

    Morris, Jill K.; Vidoni, Eric D.; Honea, Robyn A.; Burns, Jeffrey M.

    2013-01-01

    Insulin resistance and Type 2 Diabetes are associated with cognitive decline and increased risk for Alzheimer’s disease (AD). Relatively few studies have assessed the impact of metabolic dysfunction on conversion to AD in mild cognitive impairment (MCI), and it is unclear whether glycemic status is associated with clinically-relevant measures of cognitive decline and brain structure in MCI. This study used the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database to examine the relation...

  3. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND)

    OpenAIRE

    Stephan, Blossom CM; Matthews, Fiona E; Khaw, Kay-Tee; Dufouil, Carole; Brayne, Carol

    2009-01-01

    Identifying the causes of dementia is important in the search for effective preventative and treatment strategies. The concept of mild cognitive impairment (MCI), as prodromal dementia, has been useful but remains controversial since in population-based studies it appears to be a limited predictor of progression to dementia. Recognising the relative contribution of neurodegenerative and vascular causes, as well as their interrelationship, may enhance predictive accuracy. The concept of vascul...

  4. Diagnosis advances in vascular cognitive impairment

    Institute of Scientific and Technical Information of China (English)

    Hua Zhou; Zhong Zhao

    2009-01-01

    Vascular cognitive impairment(VCI) encompasses the entire range of cognitive deficits associated with cerebrovascular disease(CVD), from mild deficits with little or no functional impairment, such as vascular cognitive impairment-no dementia(VCIND), to full-blown vascular dementia(VaD). Accurate diagnosis of vascular cognitive impairment is important but may be difficult. In this review we report advances in VCI in the following areas: etiology, subtypes, neuropsychology, biomarkers, neuroimaging, and diagnostic criteria.

  5. Endocrine Risk Factors for Cognitive Impairment

    OpenAIRE

    Moon, Jae Hoon

    2016-01-01

    Cognitive impairment, including Alzheimer's disease and other kinds of dementia, is a major health problem in older adults worldwide. Although numerous investigators have attempted to develop effective treatment modalities or drugs, there is no reasonably efficacious strategy for preventing or recovering from cognitive impairment. Therefore, modifiable risk factors for cognitive impairment have received attention, and the growing literature of metabolic risk factors for cognitive impairment h...

  6. Impaired sleep and allostatic load

    DEFF Research Database (Denmark)

    Clark, Alice Jessie; Dich, Nadya; Lange, Theis;

    2014-01-01

    Objective: Understanding the mechanisms linking sleep impairment to morbidity and mortality is important for future prevention, but these mechanisms are far from elucidated. We aimed to determine the relation between impaired sleep, both in terms of duration and disturbed sleep, and allostatic load...... Biobank with comprehensive information on sleep duration, disturbed sleep, objective measures of an extensive range of biological risk markers, and physical conditions. Results: Long sleep (mean difference 0.23; 95% confidence interval, 0.13, 0.32) and disturbed sleep (0.14; 0.06, 0.22) were associated...... with higher AL as well as with high-risk levels of risk markers from the anthropometric, metabolic, and immune system. Sub-analyses suggested that the association between disturbed sleep and AL might be explained by underlying disorders. Whereas there was no association between short sleep and AL, the...

  7. The Relationship between Visual Impairment and Gestures.

    Science.gov (United States)

    Frame, Melissa J.

    2000-01-01

    A study found the gestural activity of 15 adolescents with visual impairments differed from that of 15 adolescents with sight. Subjects with visual impairments used more adapters (especially finger-to-hand gestures) and fewer conversational gestures. Differences in gestural activity by degree of visual impairment and grade in school were also…

  8. Alcohol and the Physically Impaired: Special Focus.

    Science.gov (United States)

    Boros, Alexander, Ed.

    1989-01-01

    The articles in this special issue explore the connections between the dual disabilities of alcohol abuse and physical impairment, and reflect progress made in exploring the causes and treatments of alcohol abuse among the physically impaired. Selected articles include: "Results of a Model Intervention Program for Physically Impaired Persons"…

  9. Specific Language Impairment Across Languages

    OpenAIRE

    Leonard, Laurence B.

    2013-01-01

    Children with specific language impairment (SLI) have a significant and longstanding deficit in spoken language ability that adversely affects their social and academic well-being. Studies of children with SLI in a wide variety of languages reveal diverse symptoms, most of which seem to reflect weaknesses in grammatical computation and phonological short-term memory. The symptoms of the disorder are sensitive to the type of language being acquired, with extraordinary weaknesses seen in those ...

  10. Nutrition in neurologically impaired children

    OpenAIRE

    2009-01-01

    Malnutrition, either under- or overnutrition, is a common condition among neurologically impaired children. Energy needs are difficult to define in this heterogeneous population, and there is a lack of information on what normal growth should be in these children. Non-nutritional factors may influence growth, but nutritional factors such as insufficient caloric intake, excessive nutrient losses and abnormal energy metabolism also contribute to growth failure. Malnutrition is associated with s...

  11. Epigenetic Treatments for Cognitive Impairments

    OpenAIRE

    Day, Jeremy J.; Sweatt, J. David

    2011-01-01

    Epigenetic mechanisms integrate signals from diverse intracellular transduction cascades and in turn regulate genetic readout. Accumulating evidence has revealed that these mechanisms are critical components of ongoing physiology and function in the adult nervous system, and are essential for many cognitive processes, including learning and memory. Moreover, a number of psychiatric disorders and syndromes that involve cognitive impairments are associated with altered epigenetic function. In t...

  12. Multilingualism and Specific Language Impairment

    OpenAIRE

    Engel de Abreu, Pascale

    2014-01-01

    Is a multilingual education beneficial for children? What are the optimal conditions under which a child can become perfectly multilingual? When should we be concerned about a multilingual child's language skills? What are the signs of Specific Language Impairment in a child who speaks more than one language? Developmental psychologist and Associate Professor in multilingual cognitive development at the University of Luxembourg Pascale Engel de Abreu will address these questions based on what...

  13. Electrophysiology in visually impaired children

    OpenAIRE

    Genderen, Maria Michielde van

    2006-01-01

    Inherited retinal disorders and posterior visual pathway abnormalities are important causes of visual impairment in children. Visual electrophysiology often is indispensable in diagnosing these conditions. This thesis shows the wide range of use of pediatric electro-ophthalmology, and demonstrates its value in establishing diagnoses and predicting the course of a disease, with consequences for the rehabilitation process. The electrophysiological results also contribute to the understanding of...

  14. Cognitive impairment in Parkinson's disease.

    Science.gov (United States)

    Cosgrove, Jeremy; Alty, Jane Elizabeth; Jamieson, Stuart

    2015-04-01

    Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). Longitudinal cohort studies have demonstrated that approximately 50% of those with PD develop dementia after 10 years, increasing to over 80% after 20 years. Deficits in cognition can be identified at the time of PD diagnosis in some patients and this mild cognitive impairment (PD-MCI) has been studied extensively over the last decade. Although PD-MCI is a risk factor for developing Parkinson's disease dementia there is evidence to suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses. The major pathological correlate of Parkinson's disease dementia is Lewy body deposition in the limbic system and neocortex although Alzheimer's related pathology is also an important contributor. Pathological damage causes alteration to neurotransmitter systems within the brain, producing behavioural change. Management of cognitive impairment in PD requires a multidisciplinary approach and accurate communication with patients and relatives is essential. PMID:25814509

  15. Sleep, Torpor and Memory Impairment

    Science.gov (United States)

    Palchykova, S.; Tobler, I.

    It is now well known that daily torpor induces a sleep deficit. Djungarian hamsters emerging from this hypometabolic state spend most of the time in sleep. This sleep is characterized by high initial values of EEG slow-wave activity (SWA) that monotonically decline during recovery sleep. These features resemble the changes seen in numerous species during recovery after prolonged wakefulness or sleep deprivation (SD). When hamsters are totally or partially sleep deprived immediately after emerging from torpor, an additional increase in SWA can be induced. It has been therefore postulated, that these slow- waves are homeostatically regulated, as predicted by the two-process model of sleep regulation, and that during daily torpor a sleep deficit is accumulated as it is during prolonged waking. The predominance of SWA in the frontal EEG observed both after SD and daily torpor provides further evidence for the similarity of these conditions. It has been shown in several animal and human studies that sleep can enhance memory consolidation, and that SD leads to memory impairment. Preliminary data obtained in the Djungarian hamster showed that both SD and daily torpor result in object recognition deficits. Thus, animals subjected to SD immediately after learning, or if they underwent an episode of daily torpor between learning and retention, displayed impaired recognition memory for complex object scenes. The investigation of daily torpor can reveal mechanisms that could have important implications for hypometabolic state induction in other mammalian species, including humans.

  16. Empathy in schizophrenia: impaired resonance.

    Science.gov (United States)

    Haker, Helene; Rössler, Wulf

    2009-09-01

    Resonance is the phenomenon of one person unconsciously mirroring the motor actions as basis of emotional expressions of another person. This shared representation serves as a basis for sharing physiological and emotional states of others and is an important component of empathy. Contagious laughing and contagious yawning are examples of resonance. In the interpersonal contact with individuals with schizophrenia we can often experience impaired empathic resonance. The aim of this study is to determine differences in empathic resonance-in terms of contagion by yawning and laughing-in individuals with schizophrenia and healthy controls in the context of psychopathology and social functioning. We presented video sequences of yawning, laughing or neutral faces to 43 schizophrenia outpatients and 45 sex- and age-matched healthy controls. Participants were video-taped during the stimulation and rated regarding contagion by yawning and laughing. In addition, we assessed self-rated empathic abilities (Interpersonal Reactivity Index), psychopathology (Positive and Negative Syndrome Scale in the schizophrenia group resp. Schizotypal Personality Questionnaire in the control group), social dysfunction (Social Dysfunction Index) and executive functions (Stroop, Fluency). Individuals with schizophrenia showed lower contagion rates for yawning and laughing. Self-rated empathic concern showed no group difference and did not correlate with contagion. Low rate of contagion by laughing correlated with the schizophrenia negative syndrome and with social dysfunction. We conclude that impaired resonance is a handicap for individuals with schizophrenia in social life. Blunted observable resonance does not necessarily reflect reduced subjective empathic concern. PMID:19377866

  17. 20 CFR 416.921 - What we mean by a not severe impairment(s) in an adult.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What we mean by a not severe impairment(s) in an adult. 416.921 Section 416.921 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL... Disability § 416.921 What we mean by a not severe impairment(s) in an adult. (a) Non-severe impairment(s)....

  18. Vision impairment in Liverpool: prevalence and morbidity.

    OpenAIRE

    Rogers, M.

    1996-01-01

    A database related to the activities of the Liverpool vision assessment team was used to identify all children with vision impairment aged 0-16 years, resident in Liverpool, UK, on 1 April 1995. Prevalence rates were calculated for all children with vision impairment, and separately for two groups: those with uncomplicated vision impairment, and those with additional pathology. Visual tract pathologies were tabulated and compared. Associated handicapping conditions were defined and the extent...

  19. Visual Impairments in Children with Cerebral Palsy

    OpenAIRE

    Alimović, Sonja

    2012-01-01

    Cerebral palsy (CP) is the neurological developmental disorder mainly affecting motor abilities. Considering the high rate of associated impairments even the definition of CP is revised and changed. Visual impairment is one of the most common associated impairment. Unfortunately, it is often unrecognized and considered to be a normal consequence of motor problems. Sense of sight is most important for early child development, motivation, learning through imitation. It is, therefore, indispensa...

  20. Family Members Responding to a Visual Impairment.

    Science.gov (United States)

    Tuttle, Dean W.

    1986-01-01

    A literature review regarding family adjustment to a visually impaired family member considered the stages of denial, withdrawal, acceptance, depression, reaffirmation, coping, mobilization, and self-acceptance. (CB)

  1. The Differences Between Revaluation and Assets Impairment

    Directory of Open Access Journals (Sweden)

    BOBIȚAN Nicolae

    2013-05-01

    Full Text Available Impairment and revaluation are terms closely related to one another, with subtle differences. Revaluation and impairment both require the company to evaluate the assets for their fair value, and then take appropriate action in updating the accounting books. The major difference between the two is that a revaluation can be made upwards (to increase the value of the asset to market value or downwards (to ecrease the value. An impairment, on the other hand, only refers to one of the two, a fall in the market value which is then written down. The purpose of the paper is to establish what are the differences between revaluation and impairment of assets.

  2. Evacuation characteristics of visually impaired people

    DEFF Research Database (Denmark)

    Sørensen, Janne Gress; Dederichs, Anne

    2015-01-01

    Evacuation characteristics for blind and visually impaired people are presented in the current study. The study was carried out in 2011 and engaged 40 participants in the age from 10 to 69 years. The participants had impairments for all of the four Danish categories for visual impairments (A......-bodied adults. It was found that people with visual impairments were able to uphold a higher walking speed descending stairs than able-bodied adults for increasing person density. The initial walking speed on horizontal planes is lower than the value suggested by the N&M-model. The horizontal mean free walking...

  3. Cognitive impairment in Parkinson's disease.

    Science.gov (United States)

    Ransmayr, Gerhard

    2015-12-01

    Parkinson's disease is the second most frequent neurodegenerative disorder. There is significantly elevated risk of cognitive decline and associated neuropsychiatric symptoms. Dementia may develop insidiously several years after manifestation of Parkinson motor symptoms (dementia associated with Parkinson's disease; Parkinson's disease dementia) or in close temporal relationship (within one year) after onset of motor symptoms (Dementia with Lewy bodies). There are clinical, pathophysiological and therapeutic similarities between these two conditions. Men are more frequently affected than women. Risk factor or indicators are advanced age at disease onset, disease duration, rigidity, akinesia and posture and gait impairment and falls as opposed to tremor dominance, and associated neuropsychiatric symptoms (depression, apathy, hallucinosis, delirium). Dementia is treatable with cholinesterase inhibitors (rivastigmine, donepezil), memantine, and adjustment of the pharmacological regimen of parkinsonian motor symptoms. Concomitant autonomic nervous system symptoms and neuropsychiatric complications warrant early clinical awareness and are accessible to pharmacological therapy. PMID:26609664

  4. Verbal memory impairments in dyslexia.

    Science.gov (United States)

    Kramer, J H; Knee, K; Delis, D C

    2000-01-01

    Although verbal memory deficits are frequently reported in reading disabled children, the specific mechanisms underlying these impairments have yet to be clearly defined. The present study used the California Verbal Learning Test-Children's Version (CVLT-C) to assess verbal learning in 57 dyslexic children and 114 controls matched for gender, age, and WISC-R Vocabulary score. Three areas of verbal memory were investigated: Recall and recognition, use of learning strategies, and interference effects. The dyslexic group learned the list items more slowly, recalled fewer words on the last learning trial and the delayed trials, and performed less well on the recognition condition. Dyslexics and controls displayed similar vulnerability to interference, but group differences were evident in serial position effects. Taken together, our data suggest that dyslexics have less efficient rehearsal and encoding mechanisms, resulting in deficient encoding of new information, but normal retention and retrieval. PMID:14590570

  5. Clean Water Act 303(d) Listed Impaired Waters and their Causes of Impairment from All Years

    Data.gov (United States)

    U.S. Environmental Protection Agency — Waters identified as impaired as well as their associated causes of impairment from all approved Clean Water Act 303(d) lists submitted by the states. Includes all...

  6. Library Automation Design for Visually Impaired People

    Science.gov (United States)

    Yurtay, Nilufer; Bicil, Yucel; Celebi, Sait; Cit, Guluzar; Dural, Deniz

    2011-01-01

    Speech synthesis is a technology used in many different areas in computer science. This technology can bring a solution to reading activity of visually impaired people due to its text to speech conversion. Based on this problem, in this study, a system is designed needed for a visually impaired person to make use of all the library facilities in…

  7. Resources for Visually Impaired or Blind Students.

    Science.gov (United States)

    Hart, Elizabeth

    2000-01-01

    Suggests resources for school librarians who need materials for visually impaired or blind students. Highlights include the National Library Service for the Blind and Physically Handicapped; Louis Database of Accessible Materials for People Who Are Blind or Visually Impaired; Braille books; large print books, audio books; assistive technology; and…

  8. Pegasus Project for the Hearing-Impaired.

    Science.gov (United States)

    Krahe, Jane M.

    The Pegasus Project offered nine gifted hearing impaired students (11-15 years old) a summer enrichment experience with hearing peers. Courses included computer programming, literature, fine arts, physical and biological sciences, math enrichment, and sign language. All hearing impaired students also attended a special class on issues for the…

  9. Behaviour Problems in Children with Language Impairment

    Science.gov (United States)

    van Daal, John; Verhoeven, Ludo; van Balkom, Hans

    2007-01-01

    Background: Language impairment is often associated with behaviour problems. However, detailed relations between different types of language impairment and specific behaviour problems in children have yet to be demonstrated. The present study attempted to do just this with an eye to the implications to identify foci for early intervention.…

  10. Signs and Symptoms of the Impaired Counselor.

    Science.gov (United States)

    Emerson, Shirley; Markos, Patricia A.

    1996-01-01

    Although the problem of impaired professionals has been with us for as long as professionals have been so designated, this article considers potential harm to clients and the profession's obligation to monitor its members and provide appropriate rehabilitation. Definitions of distress and professional impairment are discussed, as are the…

  11. Cognitive impairment in COPD: a systematic review

    Directory of Open Access Journals (Sweden)

    Irene Torres-Sánchez

    2015-04-01

    Full Text Available The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains in such patients. To that end, we performed a systematic review using the following databases: PubMed, Scopus, and ScienceDirect. We included articles that provided information on cognitive impairment in COPD patients. The review of the findings of the articles showed a significant relationship between COPD and cognitive impairment. The most widely studied cognitive domains are memory and attention. Verbal memory and learning constitute the second most commonly impaired cognitive domain in patients with COPD. The prevalence of impairment in visuospatial memory and intermediate visual memory is 26.9% and 19.2%, respectively. We found that cognitive impairment is associated with the profile of COPD severity and its comorbidities. The articles reviewed demonstrated that there is considerable impairment of the cognitive domains memory and attention in patients with COPD. Future studies should address impairments in different cognitive domains according to the disease stage in patients with COPD.

  12. Endocrine Risk Factors for Cognitive Impairment.

    Science.gov (United States)

    Moon, Jae Hoon

    2016-06-01

    Cognitive impairment, including Alzheimer's disease and other kinds of dementia, is a major health problem in older adults worldwide. Although numerous investigators have attempted to develop effective treatment modalities or drugs, there is no reasonably efficacious strategy for preventing or recovering from cognitive impairment. Therefore, modifiable risk factors for cognitive impairment have received attention, and the growing literature of metabolic risk factors for cognitive impairment has expanded from epidemiology to molecular pathogenesis and therapeutic management. This review focuses on the epidemiological evidence for the association between cognitive impairment and several endocrine risk factors, including insulin resistance, dyslipidemia, thyroid dysfunction, vitamin D deficiency, and subclinical atherosclerosis. Researches suggesting possible mechanisms for this association are reviewed. The research investigating modifiable endocrine risk factors for cognitive impairment provides clues for understanding the pathogenesis of cognitive impairment and developing novel treatment modalities. However, so far, interventional studies investigating the beneficial effect of the "modification" of these "modifiable risk factors" on cognitive impairment have reported variable results. Therefore, well-designed, randomized prospective interventional studies are needed. PMID:27118278

  13. Depressive Symptoms and Impaired Respiration in Sleep.

    Science.gov (United States)

    Bliwise, Donald L.; And Others

    1986-01-01

    Associations between depression and impaired respiration in sleep are frequently noted clinically. This relationship was documented psychometrically with the Geriatric Depression Scale, a self-report measure of nonsomatic depressive symptoms. Mean values and effect size suggest that impaired respiration in sleep was associated with only relatively…

  14. Impaired gap detection in juvenile microgyric rats.

    Science.gov (United States)

    Peiffer, Ann M; Friedman, Jennifer T; Rosen, Glenn D; Fitch, R Holly

    2004-09-17

    Previous research with adult animal models links the presence of cortical neuromigrational anomalies (i.e., microgyria similar to that found in brains of dyslexics) with rapid auditory processing (RAP) impairments. RAP impairments are in turn found in children with specific language impairment (SLI) and also in individuals with dyslexia. Gap detection, a simple measure of auditory temporal acuity, appears to be impaired in children with SLI but not in dyslexic adults, even though both groups exhibit impaired processing on more complex, rapid auditory tasks. In the current study, juvenile rats with bilateral microgyria, but not their adult counterparts, exhibited impaired detection of short duration silent gaps in white noise when compared to age-matched sham littermates. Results lend further support to: (1) an association between neuromigrational anomalies and RAP impairments; and (2) the validity of an animal model of RAP impairments associated with language disturbances in humans. Current results also support the view that auditory processing disturbances associated with cortical malformations may be evident early in development at a relatively "low" level (e.g., simple gap detection), but may require "higher-order" auditory discrimination tasks (e.g., tone sequences, phonemic discriminations) to be elicited later in life. PMID:15351496

  15. Mild Cognitive Impairment Status and Mobility Performance

    DEFF Research Database (Denmark)

    Pedersen, Mette; Holt, Nicole E; Grande, Laura;

    2014-01-01

    : An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (a...

  16. Survivable Impairment-Aware Traffic Grooming

    NARCIS (Netherlands)

    Beshir, A.; Nuijts, R.; Malhotra, R.; Kuipers, F.

    2011-01-01

    Traffic grooming allows efficient utilization of network capacity by aggregating several independent traffic streams into a wavelength. In addition, survivability and impairment-awareness (i.e., taking into account the effect of physical impairments) are two important issues that have gained a lot o

  17. Cognitive impairment and mortality among nonagenarians

    DEFF Research Database (Denmark)

    Andersen, Kjeld; Nybo, Hanne; Gaist, David;

    2002-01-01

    regression analysis was applied to adjust for a number of known and suspected factors known or suspected of being associated with cognition and mortality (e.g. sociodemographic factors, sex, smoking, alcohol consumption, depressive symptoms, and physical abilities), and yielded hazard ratios (95% confidence......Cognitive impairment has been associated with increased mortality. Most studies, however, have only included small numbers, if at all, of the very old. In a large nationwide survey of all Danes born in 1905 and still alive in 1998, where the baseline examination was conducted, we examined the...... impact of cognitive impairment on mortality over a 2-year period. No cognitive impairment was defined as a score of 24-30 points on the Mini Mental State Examination, mild cognitive impairment was defined as a score of 18-23 points, and severe impairment was defined as a score of 0-17 points. Cox...

  18. Impaired Leydig cell function in infertile men

    DEFF Research Database (Denmark)

    Andersson, A-M; Jørgensen, N; Frydelund-Larsen, L; Rajpert-De Meyts, E; Skakkebaek, N E

    2004-01-01

    To investigate whether an impaired Leydig cell function is present in severely oligospermic men, serum testosterone (T), LH, estradiol (E(2)), and SHBG levels in 357 idiopathic infertile men were compared with levels in 318 proven fertile men. In addition, the T/LH ratio, E(2)/T ratio, and...... fertile levels.Thus, the group of infertile men showed significant signs of impaired Leydig cell function in parallel to their impaired spermatogenesis. The association of decreased spermatogenesis and impaired Leydig cell function might reflect a disturbed paracrine communication between the seminiferous...... epithelium and the Leydig cells, triggered by distorted function of the seminiferous epithelium. On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development....

  19. A methoxydiphenidine-impaired driver.

    Science.gov (United States)

    Stachel, Nicole; Jacobsen-Bauer, Andrea; Skopp, Gisela

    2016-03-01

    Methoxydiphenidine (MXP) was first reported in 1989 as a dissociative anesthetic but did not enter the market for pharmaceuticals. The substance re-appeared in 2013 as a new psychoactive substance. A case of driving under the influence of MXP is reported. The concentration of MXP has been determined from a serum sample (57 ng/mL) by liquid chromatography tandem mass spectrometry following liquid-liquid extraction. In addition, amphetamine, methylenedioxymethamphetamine, and its major metabolite were present in concentrations of 111, 28, and 3 ng/mL, respectively. The subject presented with amnesia, out-of-body experiences, bizarre behavior, and decreased motor abilities. At present, information on human toxicity of MXP is not available. MXP is comparable in structure as well as in action at the N-methyl-D-aspartate (NMDA) receptor to phencyclidine or ketamine. Therefore, it is likely that MXP exerts similar severe psychotropic action in man. However, there is no information on the duration and intensity of MXP's impairing effects, the interpretation of a particular concentration in the blood or serum, and its detectability in routine drug screenings. Confirmation analysis may be confined to cases where the police has specific intelligence that points to MXP use. PMID:26482953

  20. Is Hearing Impairment Associated with Rheumatoid Arthritis?

    DEFF Research Database (Denmark)

    Emamifar, Amir; Bjoerndal, Kristine; Jensen Hansen, Inger Marie

    2016-01-01

    BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease that affects 1% of the population. The auditory system may be involved during the course of disease; however the association of RA and hearing impairment has not been clearly defined. OBJECTIVE: The objective of this review......, hearing test, audiometry, auditory dysfunction and rheumatoid arthritis. CONCLUSION: Based on our review it can be postulated that patients with RA are at higher risk of hearing impairment compared to healthy subjects in their course of the disease. The hearing impairment in RA seems to be a...

  1. Hydrographic and Impairment Statistics Database: FODO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: MALL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: CHAM

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: BOAF

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: DESO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: WICL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: FOSM

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: FILA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: GRSA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: ROMO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: TUPE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: FLFO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Space Activities for the Visually Impaired

    Science.gov (United States)

    Ries, J. G.; Baguio, M.

    2005-12-01

    To a visually impaired person celestial objects or concepts of space exploration are likely to be more abstract than to other people, but they encounter news about the universe through their daily life. A partnership between Texas Space Grant Consortium, The University of Texas at Austin, and the Texas School for the Blind and Visually Impaired provided the opportunity to assist visually impaired students increase their understanding of astronomy and space science. The activities helped visually impaired students activity engage in inquiry-based, hands-on astronomy activities. The experiences provided during the educator workshops, adapted instructional classroom activities, and tactile learning aids will be shared in the hopes that others may be able to incorporate these lessons into their regular teaching activities.

  14. Hydrographic and Impairment Statistics Database: CONG

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: FOSU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: CAGR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: SAGU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: WRBR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: ARPO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: SAPA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: ELRO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: GUCO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: GLBA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: HOME

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: FLNI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: DAAV

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: JODA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: NATR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: FOTH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: NATC

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: BICA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: CANY

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: RICH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: OCMU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: AMME

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: APCO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: DEWA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: PAAL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: WAPA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: RUCA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: WIHO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: FRHI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: SAFR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: FOST

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: SAMA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: SACN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: ADAM

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: SAAN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: PINN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: FOVA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: MONO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: ISRO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: APPA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: RABR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: OLYM

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: PEFO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: CORO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: CAVO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: BITH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: LACH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: CHCU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: BOST

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: SAJH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: SAND

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: GOSP

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: JICA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: VIIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: ANTI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: VICR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: CHAT

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: FOPO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: CUVA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: GOGA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: STEA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: PIRO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: PEVI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: JOFI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: WUPA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: ALPO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: PIPE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: FEHA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: NICO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: NOCA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: VAMA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: INPE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: ALFL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: ILMI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: CLBA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: AZRU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: POPO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: WRST

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: KALA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: JEFF

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: CHSC

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: SAIR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: CEBR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: JECA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Impaired decision making among morbidly obese adults.

    LENUS (Irish Health Repository)

    Brogan, Amy

    2011-02-01

    The Iowa Gambling Task (IGT) measures affective decision making and has revealed decision making impairments across a wide range of eating disorders. This study aimed to investigate affective decision making in severely obese individuals.

  19. Hydrographic and Impairment Statistics Database: NISI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: ZION

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: POCH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: CHCH

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: HOFU

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: MOJA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: MORA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: CARI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: HALE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: MIMI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: GREE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: GATE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: CASA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: ELMA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: ASIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: NACC

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: RORI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: LAKE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: THST

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: KOWA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: GERO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: CACL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: TUIN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: HSTR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: LAVO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: ALAG

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: EDIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Tone language fluency impairs pitch discrimination

    Directory of Open Access Journals (Sweden)

    IsabellePeretz

    2011-07-01

    Full Text Available Here we present evidence that native speakers of a tone language, in which pitch contributes to word meaning, are impaired in the discrimination of falling pitches in tone sequences, as compared to speakers of a non-tone language. Both groups were presented with monotonic and isochronous sequences of five tones (i.e., constant pitch and intertone interval. They were required to detect when the fourth tone was displaced in pitch or time. While speakers of a tone language performed more poorly in the detection of downward pitch changes, they did not differ from non-tone language speakers in their perception of upward pitch changes or in their perception of subtle time changes. Moreover, this impairment cannot be attributed to low musical aptitude since the impairment remains unchanged when individual differences in musical pitch-based processing is taken into account. Thus, the impairment appears highly specific and may reflect the influence of statistical regularities of tone languages.

  7. Hydrographic and Impairment Statistics Database: ACAD

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: NAVA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: GRKO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: MCHO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: TUZI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: GWMP

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: CANA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: HOBE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: SUCR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: WOTR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: PRWI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: TONT

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: FOUN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: CHIR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: MAVA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: HEHO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: HOFR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: JOTR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: FOUS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: VAFO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: BIBE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: FODA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: FOMA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: CURE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: CUIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: SHIL

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: MOCR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: SPAR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: PAGR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: BRVB

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: KATM

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: ANJO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: JOFK

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: PETE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. Hydrographic and Impairment Statistics Database: PUHE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Hydrographic and Impairment Statistics Database: KIMO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  3. Hydrographic and Impairment Statistics Database: CALO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  4. Hydrographic and Impairment Statistics Database: HAFE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  5. Hydrographic and Impairment Statistics Database: CAHA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  6. Hydrographic and Impairment Statistics Database: COLO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  7. Hydrographic and Impairment Statistics Database: CIRO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  8. Hydrographic and Impairment Statistics Database: AMIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  9. Hydrographic and Impairment Statistics Database: LABE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  10. Hydrographic and Impairment Statistics Database: LEWI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  11. Hydrographic and Impairment Statistics Database: NEBE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  12. Hydrographic and Impairment Statistics Database: GRTE

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  13. Hydrographic and Impairment Statistics Database: ORPI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  14. Hydrographic and Impairment Statistics Database: FOBO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  15. Hydrographic and Impairment Statistics Database: ROCR

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  16. Hydrographic and Impairment Statistics Database: SEMO

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  17. Hydrographic and Impairment Statistics Database: MIIN

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  18. Hydrographic and Impairment Statistics Database: CHIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  19. Hydrographic and Impairment Statistics Database: DEVA

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  20. Hydrographic and Impairment Statistics Database: LIRI

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  1. OPHTHALMOLOGIC ABNORMALITIES IN CHILDREN WITH IMPAIRED HEARING

    OpenAIRE

    Inderjit; Jagdeepak; Prempal; Anup Narayanrao

    2014-01-01

    AIM: To determine the nature of ophthalmologic abnormalities in severe and profound grades of hearing impaired children and to treat visual impairment if any at the earliest . MATERIAL AND METHODS: Study was conducted on100 children in the age group of 5 - 14 years with severe and profound hearing loss visiting outpatient department of Ram Lal Eye and ENT hospital Govt. Medical College Amritsar and subjected to detailed ophthalmological examination. R...

  2. Gestural Interfaces for Hearing-Impaired Communication

    OpenAIRE

    Aran, Oya; Burger, Thomas; Akarun, Lale; Caplier, Alice

    2008-01-01

    International audience Gestural interfaces, besides providing natural means of human computer interaction for everyone, enable the hearing impaired to use sign language or better understand speech through vision. This chapter overviews (1) the various modalities involved in gestured languages (2) the mean to automatically apprehend them individually and (3) to fuse them in order to provide a communication medium adapted to hearing-impaired. We present two example applications, a sign langu...

  3. Creating workshops for blind and visually impaired

    OpenAIRE

    Rot, Peter

    2013-01-01

    The thesis Načrtovanje projektnih delavnic za osebe s slepoto in slabovidnostjo discusses the planning stage and the performance of projects for blind and visually impaired adults. It points out the positive effects of those projects on the life of an individual. Adults and senior citizens who are not blind from birth often lack professional help which would enable their adaptation to the life of blind and visually impaired. The thesis concentrates on one of the ways of integrating blind and ...

  4. Banknote design for the visually impaired

    OpenAIRE

    Hans de Heij

    2009-01-01

    The visually impaired are divided in three subgroups: colour-blind, partially sighted and blind people. Their first needs are useful denomination features rather than security features, as they help them in determining a banknote's value. This study provides a historical overview of banknote design features for the visually impaired, especially as applied in the former Dutch guilder notes. Furthermore, it looks into the methodology of banknotes tests for the colour-blind, showing images of ho...

  5. Navigation of blind and visually impaired people

    OpenAIRE

    Axer, Steffen; Belz, Jörg; Leske, Kathrin; Friedrich, Bernhard; Hesse, Tobias; Vollrath, Mark

    2015-01-01

    The mobility of the blind and visually impaired is associated with many barriers and risks. To secure crossings, signalized intersections are partially equipped with acoustic or tactile indicators. However, environmental conditions might interfere with the acoustic identification of the green time. Furthermore, information such as intersection topology, bicycle traffic or the curb structure is not accessible to visually impaired road users. Therefore, most trips are limited to trained routes....

  6. Obesity and Hypertriglyceridemia Produce Cognitive Impairment

    OpenAIRE

    Farr, Susan A.; Yamada, Kelvin A.; Butterfield, D. Allan; Abdul, H. Mohammad; Xu, Lin; Miller, Nicole E.; Banks, William A.; Morley, John E.

    2008-01-01

    Obesity is associated with cognitive impairments. Long-term mechanisms for this association include consequences of hyperglycemia, dyslipidemia, or other factors comprising metabolic syndrome X. We found that hypertriglyceridemia, the main dyslipidemia of metabolic syndrome X, is in part responsible for the leptin resistance seen in obesity. Here we determined whether triglycerides have an immediate and direct effect on cognition. Obese mice showed impaired acquisition in three different cogn...

  7. Impaired visuomotor adaptation in adults with ADHD

    OpenAIRE

    Kurdziel, Laura B. F.; Dempsey, Katherine; Zahara, Mackenzie; Valera, Eve; Rebecca M.C. Spencer

    2015-01-01

    Attention-deficit/hyperactivity disorder (ADHD) is a prevalent psychiatric disorder in children that often continues into adulthood. It has been suggested that motor impairments in ADHD are associated with underlying cerebellar pathology. If such is the case, individuals with ADHD should be impaired on motor tasks requiring healthy cerebellar function. To test this, we compared performance of individuals with ADHD and ADHD-like symptoms with non-ADHD controls on a visuomotor adaptation task k...

  8. Cognitive impairment in COPD: a systematic review

    OpenAIRE

    Irene Torres-Sánchez; Elisabeth Rodríguez-Alzueta; Irene Cabrera-Martos; Isabel López-Torres; Maria Paz Moreno-Ramírez; Marie Carmen Valenza

    2015-01-01

    The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains in such patients. To that end, we performed a systematic review using the following databases: PubMed, Scopus, and ScienceDirect. We included articles that provided information on cognitive impairment in COPD patients. The review of the findin...

  9. Cognitive impairment in COPD: a systematic review*

    OpenAIRE

    Torres-Sánchez, Irene; Rodríguez-Alzueta, Elisabeth; Cabrera-Martos, Irene; López-Torres, Isabel; Moreno-Ramírez, Maria Paz; Valenza, Marie Carmen

    2015-01-01

    The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains in such patients. To that end, we performed a systematic review using the following databases: PubMed, Scopus, and ScienceDirect. We included articles that provided information on cognitive impairment in COPD patients. The review of the findin...

  10. Difficulties in Parenting Hearing-Impaired Children

    Directory of Open Access Journals (Sweden)

    Dr. Gita Movallali

    2010-06-01

    Full Text Available Background and Aim: Despite the abundance of literature about deaf children, few works specifically address the concept and practice of difficulties in parenting hearing-impaired children. The first interactions of the child are with his parents, and parents have the most important role in child improvements during early intervention programs. The main purpose of this paper was to investigate different aspects of parenting hearing-impaired children.Methods: In this article, we reviewed all aspects of parenting hearing-impaired children in papers from 1984-2009 in Medline, Scopus and Proquest and relative textbooks. The semi-professional role of parents of hearing-impaired children make them feel under excessive stress and this usually affects their other roles as fathers and mothers. Many factors including child age, type of hearing loss and parents’ individual characteristics may influence the impact of child’s hearing loss on parents.Conclusion: Parenting a hearing-impaired child is both similar and different to parenting any other child. Where there are differences, there are usually challenges too. Taking support and advice from professionals and other parents are necessary and invaluable for parents of hearing-impaired children.

  11. 20 CFR 404.1576 - Impairment-related work expenses.

    Science.gov (United States)

    2010-04-01

    ... deduct payments you make for physical therapy which you require because of your impairment(s) and which... physical fitness. If it is prescribed and used as necessary treatment of your impairment and necessary to... physical examinations, optician services (unrelated to a disabling visual impairment) and...

  12. The effect of hearing impairment on mathematical skill of hearing-impaired elementary-school students

    Directory of Open Access Journals (Sweden)

    Azam Sharifi

    2012-06-01

    Full Text Available Background and Aim: Hearing impairment can effect many educational abilities and will lead in a dealy in his growth. The objective of this research was to study the effect of hearing impairment on mathematical skill of hearing-impaired students of 4th grade of elementary in contrast with normal-hearing students.Methods: The project was cross-sectional and the tool used was the international standard booklet of mathematical questions. There has been 35 hearing-impaired students with range of moderately sever-profound hearing loss selected from the 4th grade of elementary from exceptional schools in Ray, Pakdasht and Varamina, Iran, and 35 normal-hearing students were randomly selected from ordinary schools next to exceptional schools.Results: By analyzing the outcomes, the normal-hearing students showed a better result in knowing, application, argument in aspects of cognitive in contrast with hearing-impaired students and there has been a meaningful difference (p<0.05. There was not a meaningful difference in mathematical skill between Ray, Pakdasht and Varamina, Iran in hearing-impaired and normal-hearing groups.Conclusion: The hearing impairment effects learing of mathematical skill. It is important for hearing-impaired students to presentation various methods in instruction in progress deductive thought and cognitive structure and also development in concepts understand in mathematical domain in rehabilitation services.

  13. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

    Science.gov (United States)

    Fujisawa, Haruki; Sugimura, Yoshihisa; Takagi, Hiroshi; Mizoguchi, Hiroyuki; Takeuchi, Hideyuki; Izumida, Hisakazu; Nakashima, Kohtaro; Ochiai, Hiroshi; Takeuchi, Seiji; Kiyota, Atsushi; Fukumoto, Kazuya; Iwama, Shintaro; Takagishi, Yoshiko; Hayashi, Yoshitaka; Arima, Hiroshi; Komatsu, Yukio; Murata, Yoshiharu; Oiso, Yutaka

    2016-03-01

    Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response to adaptation by the brain, recent evidence suggests that chronic hyponatremia may be linked to attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction in quality of life and may be a significant cause of mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, and cancer may also affect brain function, the contribution of hyponatremia alone to neurologic manifestations and the underlying mechanisms remain unclear. Using a syndrome of inappropriate secretion of antidiuretic hormone rat model, we show here that sustained reduction of serum sodium ion concentration induced gait disturbances; facilitated the extinction of a contextual fear memory; caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3-CA1 synapses. In vivo microdialysis revealed an elevated extracellular glutamate concentration in the hippocampus of chronically hyponatremic rats. A sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. Furthermore, gait and memory performances of corrected hyponatremic rats were equivalent to those of control rats. Thus, these results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality. PMID:26376860

  14. Cognitive impairment and stroke in elderly patients.

    Science.gov (United States)

    Lo Coco, Daniele; Lopez, Gianluca; Corrao, Salvatore

    2016-01-01

    We reviewed current knowledge about the interaction between stroke and vascular risk factors and the development of cognitive impairment and dementia. Stroke is increasingly recognized as an important cause of cognitive problems and has been implicated in the development of both Alzheimer's disease and vascular dementia. The prevalence of cognitive impairment after stroke is high, and their combined effects significantly increase the cost of care and health resource utilization, with reflections on hospital readmissions and increased mortality rates. There is also substantial evidence that vascular risk factors (such as hypertension, diabetes, obesity, dyslipidemia, and tobacco smoking) are independently associated with an increased risk of cognitive decline and dementia. Thus, a successful management of these factors, as well as optimal acute stroke management, might have a great impact on the development of cognitive impairment. Notwithstanding, the pathological link between cognitive impairment, stroke, and vascular risk factors is complex and still partially unclear so that further studies are needed to better elucidate the boundaries of this relationship. Many specific pharmacological treatments, including anticholinergic drugs and antihypertensive medications, and nonpharmacological approaches, such as diet, cognitive rehabilitation, and physical activity, have been studied for patients with vascular cognitive impairment, but the optimal care is still far away. Meanwhile, according to the most recent knowledge, optimal stroke care should also include cognitive assessment in the short and long term, and great efforts should be oriented toward a multidisciplinary approach, including quality-of-life assessment and support of caregivers. PMID:27069366

  15. Effect of Somatosensory Impairments on Balance Control

    Directory of Open Access Journals (Sweden)

    Alireza Hassanpour

    2012-10-01

    Full Text Available Background and Aim: The somatosensory system is one of the most effective systems in balance control. It consists of peripheral and central components. Knowing the role of these components in balance control assists the developing of effective rehabilitation protocols. In some diseases peripheral components and in others central components are impaired. This paper reviews the effect of impairment of peripheral and central components of the somatosensory system on balance control.Methods: In this study publication about somatosensory impairments from 1983 through 2011 in PubMed, Scopus, ProQuest, Google Scholar, Iran Medex, Iran Doc and Magiran were reviewed. Medical subject headings terms and keywords related to balance, somatosensory, somatosensory loss, and sensory integration/processing were used to perform the searches.Conclusion: Somatosensory impairments either with peripheral or central origin, can cause problems in balance control. However, these problems are not considered in some patients. In these impairments, balance training is recommended to be used alongside other routine treatments in the patients' rehabilitation programs.

  16. Impairments in the Perception of Odor-Induced Tastes and Their Relationship to Impairments in Taste Perception

    Science.gov (United States)

    Stevenson, Richard J.; Miller, Laurie A.; Thayer, Zoe C.

    2008-01-01

    Certain odors have tastelike qualities when sniffed. To the extent that these qualities are akin to real taste experiences, impairment in perception of odor-induced tastes should be accompanied by taste impairment, and vice versa. Twelve patients were selected with possible odor-induced taste impairments or general taste impairments via a…

  17. Smart Wheel Chair for Visually Impaired

    Directory of Open Access Journals (Sweden)

    Dev Pratap Singh

    2014-08-01

    Full Text Available The visually impaired persons suffer from lack of confidence, restricted mobility and dependence on others in their daily life. This paper proposes an embedded system design of a smart wheel chair aiming for visually impaired using high-end technical tools like AVR Studio, ATMEGA 16 Development Board (Atmel Corporation, proximity sensors and DTMF Decoder. The movement of wheelchair is controlled by cellular phones specifically designed for the visually challenged people (Toshiba, Huawei, Sens are companies that manufacture such specific mobiles. In this paper existing designs of wheel chair are also discussed. In addition to being user-friendly, the proposed design also provides a high degree of mobility and defence against obstacles for the visually impaired. Further the design is also tested using Printed Circuit Board (PCB and the results obtained are in perfect accordance with the expectations. This proposed smart chair design outperforms the existing designs in terms of obstacle avoidance and technology.

  18. Cognitive impairment and preferences for current health

    Directory of Open Access Journals (Sweden)

    Tsevat Joel

    2009-01-01

    Full Text Available Abstract Background We assessed preferences for current health using the visual analogue scale (VAS, standard gamble (SG, time trade-off (TTO, and willingness to pay (WTP in patients with cerebral aneurysms, a population vulnerable to cognitive deficits related to aneurysm bleeding or treatment. Methods We measured VAS, SG, TTO, and WTP values for current health in 165 outpatients with cerebral aneurysms. We assessed cognitive impairment with the Mini Mental State Examination (MMSE; scores Results Eleven patients (7% had MMSE scores Conclusion Cognitive impairment is associated with lower preferences for current health in patients with cerebral aneurysms. Cognitively impaired patients have poor inter-preference test correlations and different response distributions compared to unimpaired patients.

  19. Impairment of assets - between regulation and deregulation

    OpenAIRE

    Professor Traian Nicolae, Ph.D.

    2010-01-01

    Objective of IAS 36 Impairment of assets is to prescribe procedures that apply to an undertaking to ensure that its assets are carried at amounts not exceeding their recoverable amount if the carrying amount is recoverable in full. An asset is carried at an amount not exceeding the amount will be recovered through its use or sale. If this case proves, is described as impaired assets and IAS 36 requires the company to account for a loss of value. Also, the rule specifies that a business case s...

  20. Cohomologie quantique des grassmanniennes symplectiques impaires

    OpenAIRE

    Pech, Clélia

    2011-01-01

    Les grassmanniennes symplectiques impaires sont une famille d'espaces quasi-homogènes très proches des grassmanniennes symplectiques de par leur construction et leurs propriétés. Dans ce travail, j'étudie leur cohomologie classique et quantique. Pour les grassmanniennes symplectiques impaires de droites, j'obtiens une règle de Pieri quantique ainsi qu'une présentation de l'anneau de cohomologie quantique. J'en déduis la semi-simplicité de cet anneau et je détermine une collection exceptionnel...

  1. Early Language Milestones and Specific Language Impairment

    Science.gov (United States)

    Rudolph, Johanna M.; Leonard, Laurence B.

    2016-01-01

    Delayed appearance of early language milestones can be one of the first signs of a developmental disorder. In this study, we investigated how well late acquisition of language milestones predicted an outcome of specific language impairment (SLI). The sample included 150 children (76 SLI), aged 4 to 7 years old. Milestone information was collected…

  2. Cognitive impairment in MS: rehabilitation approaches.

    Science.gov (United States)

    Hämäläinen, P; Rosti-Otajärvi, E

    2016-09-01

    Cognitive deficits have been reported in 45%-70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages have been suggested to contribute to cognitive impairments in MS. There is no direct relationship between cognitive deficits and physical disability, disease duration or course of the disease. In addition to cognitive impairments, neuropsychiatric symptoms are observed in MS, the most common being alterations in mood state. Neurobehavioral deficits have multidimensional effects on the activities of daily living and quality of life. Consequently, attention should be paid to early diagnosis and treatment. Based on studies on cognitive retraining and more multimodal neuropsychological rehabilitation, both approaches show promise in the treatment of cognitive impairments and their harmful effects. This review introduces the frequency and characteristics of cognitive impairments, as well as main findings on the effects of neuropsychological rehabilitation in MS. PMID:27580900

  3. Impaired decisional impulsivity in pathological videogamers.

    Directory of Open Access Journals (Sweden)

    Michael A Irvine

    Full Text Available Pathological gaming is an emerging and poorly understood problem. Impulsivity is commonly impaired in disorders of behavioural and substance addiction, hence we sought to systematically investigate the different subtypes of decisional and motor impulsivity in a well-defined pathological gaming cohort.Fifty-two pathological gaming subjects and age-, gender- and IQ-matched healthy volunteers were tested on decisional impulsivity (Information Sampling Task testing reflection impulsivity and delay discounting questionnaire testing impulsive choice, and motor impulsivity (Stop Signal Task testing motor response inhibition, and the premature responding task. We used stringent diagnostic criteria highlighting functional impairment.In the Information Sampling Task, pathological gaming participants sampled less evidence prior to making a decision and scored fewer points compared with healthy volunteers. Gaming severity was also negatively correlated with evidence gathered and positively correlated with sampling error and points acquired. In the delay discounting task, pathological gamers made more impulsive choices, preferring smaller immediate over larger delayed rewards. Pathological gamers made more premature responses related to comorbid nicotine use. Greater number of hours played also correlated with a Motivational Index. Greater frequency of role playing games was associated with impaired motor response inhibition and strategy games with faster Go reaction time.We show that pathological gaming is associated with impaired decisional impulsivity with negative consequences in task performance. Decisional impulsivity may be a potential target in therapeutic management.

  4. Anaerobic Infections in Children with Neurological Impairments.

    Science.gov (United States)

    Brook, Itzhak

    1995-01-01

    Children with neurological impairments are prone to develop serious infection with anaerobic bacteria. The most common anaerobic infections are decubitus ulcers; gastrostomy site wound infections; pulmonary infections (aspiration pneumonia, lung abscesses, and tracheitis); and chronic suppurative otitis media. The unique microbiology of each of…

  5. Distance Education for People with Visual Impairments

    Science.gov (United States)

    Liakou, Maria; Manousou, Evaggelia

    2015-01-01

    This paper studies the standards of higher Distance Education, focusing on the Hellenic Open University, for people who have visual impairments, so that it becomes fully accessible and thus helps reduce social exclusion. Specifically, it aims to study the operational context of Distance Education, the possibilities that modern technology provides…

  6. Embedded Glove’ To Aid The Visually Impaired

    Directory of Open Access Journals (Sweden)

    Sankar Kumar S, Abarna J, Lavanya G, Nithya Lakshmi S

    2013-03-01

    Full Text Available This paper presents a model of ‘Embedded Glove’, a hand mounted tactile (vibration mechanism feedback Sound Navigation And Ranging (SONAR obstacle avoidance system, by warning through vibration motors for visually impaired to whom traveling in indoor/outdoor environments is really a difficult task. This system acts as an Electronic Travelling Aid (ETA providing independent mobility of the visually impaired. This model comprises of a glove strapped to the wrist, embedded with ultrasonic sensors, battery, microcontroller and vibrator motors. Along with being completely reliable, this system also provides to be a cost-effective guidance mechanism for the visually impaired. The system is designed to scan a wide area with a set of ultrasonic sensors which also provides a good range and speed in the detection of the obstacle. The detected obstacle is immediately notified to the possessor thereby the presence of obstacle along with its direction is conveyed to the visually impaired person by means of a tactile system. The energy consumption for the whole system is controlled by a Photovoltaic (PV panel, making it more efficient. The analysis described in this paper helps to estimate the distance at which the obstacle is present based on the reliability of measurement performed with ultrasonic sensors. It is also possible to detect the speed of moving objects in addition to direction with increased accuracy, with the enhanced response timings and varying intensities in the vibration mechanism.

  7. Type 2 diabetes mellitus and exercise impairment.

    Science.gov (United States)

    Reusch, Jane E B; Bridenstine, Mark; Regensteiner, Judith G

    2013-03-01

    Limitations in physical fitness, a consistent finding in individuals with both type I and type 2 diabetes mellitus, correlate strongly with cardiovascular and all-cause mortality. These limitations may significantly contribute to the persistent excess cardiovascular mortality affecting this group. Exercise impairments in VO2 peak and VO2 kinetics manifest early on in diabetes, even with good glycemic control and in the absence of clinically apparent complications. Subclinical cardiac dysfunction is often present but does not fully explain the observed defect in exercise capacity in persons with diabetes. In part, the cardiac limitations are secondary to decreased perfusion with exercise challenge. This is a reversible defect. Similarly, in the skeletal muscle, impairments in nutritive blood flow correlate with slowed (or inefficient) exercise kinetics and decreased exercise capacity. Several correlations highlight the likelihood of endothelial-specific impairments as mediators of exercise dysfunction in diabetes, including insulin resistance, endothelial dysfunction, decreased myocardial perfusion, slowed tissue hemoglobin oxygen saturation, and impairment in mitochondrial function. Both exercise training and therapies targeted at improving insulin sensitivity and endothelial function improve physical fitness in subjects with type 2 diabetes. Optimization of exercise functions in people with diabetes has implications for diabetes prevention and reductions in mortality risk. Understanding the molecular details of endothelial dysfunction in diabetes may provide specific therapeutic targets for the remediation of this defect. Rat models to test this hypothesis are under study. PMID:23299658

  8. Counselor Wellness and Impairment: A National Survey

    Science.gov (United States)

    Lawson, Gerard

    2007-01-01

    Counselor wellness has a direct impact on the quality of services clients receive, but little is known about the overall wellness of counselors. This study begins the process of better understanding counselor wellness by examining responses to a national survey that assessed both counselor wellness and impairment variables. (Contains 2 tables.)

  9. Psychopathology in hearing-impaired children

    NARCIS (Netherlands)

    Theunissen, Stephanie Carla Petra Maria

    2013-01-01

    Children with hearing loss are at risk for developing psychopathology, which has detrimental consequences for academic and psychosocial functioning. Therefore, the aims of this thesis were to objectify levels of psychopathology in hearing-impaired children, and to investigate the influence of variou

  10. Psychological Adjustment in Adolescents with Vision Impairment

    Science.gov (United States)

    Pinquart, Martin; Pfeiffer, Jens P.

    2012-01-01

    The present study compared psychological adjustment of 158 adolescents with vision impairment and 158 sighted adolescents with a matched-pair design using the Strengths and Difficulties Questionnaire. Adolescent self-reports and teacher reports on emotional problems, peer problems, and total difficulties showed higher scores in students with…

  11. Impaired response of pancreatic polypeptide to hypoglycaemia

    DEFF Research Database (Denmark)

    Krarup, T; Schwartz, Tania; Hilsted, J; Madsbad, S; Verlaege, O; Sestoft, L

    1979-01-01

    The pancreatic polypeptide (PP) response to insulin-induced hypoglycaemia was studied in 18 juvenile diabetics and was calculated as the difference between the prestimulatory PP concentration and the maximal concentration measured. The response was severely impaired in patients with autonomic...

  12. Impaired Decisional Impulsivity in Pathological Videogamers

    Science.gov (United States)

    Irvine, Michael A.; Worbe, Yulia; Bolton, Sorcha; Harrison, Neil A.; Bullmore, Edward T.; Voon, Valerie

    2013-01-01

    Background Pathological gaming is an emerging and poorly understood problem. Impulsivity is commonly impaired in disorders of behavioural and substance addiction, hence we sought to systematically investigate the different subtypes of decisional and motor impulsivity in a well-defined pathological gaming cohort. Methods Fifty-two pathological gaming subjects and age-, gender- and IQ-matched healthy volunteers were tested on decisional impulsivity (Information Sampling Task testing reflection impulsivity and delay discounting questionnaire testing impulsive choice), and motor impulsivity (Stop Signal Task testing motor response inhibition, and the premature responding task). We used stringent diagnostic criteria highlighting functional impairment. Results In the Information Sampling Task, pathological gaming participants sampled less evidence prior to making a decision and scored fewer points compared with healthy volunteers. Gaming severity was also negatively correlated with evidence gathered and positively correlated with sampling error and points acquired. In the delay discounting task, pathological gamers made more impulsive choices, preferring smaller immediate over larger delayed rewards. Pathological gamers made more premature responses related to comorbid nicotine use. Greater number of hours played also correlated with a Motivational Index. Greater frequency of role playing games was associated with impaired motor response inhibition and strategy games with faster Go reaction time. Conclusions We show that pathological gaming is associated with impaired decisional impulsivity with negative consequences in task performance. Decisional impulsivity may be a potential target in therapeutic management. PMID:24146789

  13. The Impaired Physician: Some Coping Mechanisms

    OpenAIRE

    Nicholson, J. F.

    1980-01-01

    Doctoring is a stressful way of life. Both normal and neurotic needs can increase the complexity of the family physician's life. Certain vulnerable doctors seek easement in tranquilizers, sedatives or alcohol, and can become addicted. Impairment may be episodic or steady, leading to deterioration in personality and ability

  14. Specific Language Impairment at Adolescence: Avoiding Complexity

    Science.gov (United States)

    Tuller, Laurice; Henry, Celia; Sizaret, Eva; Barthez, Marie-Anne

    2012-01-01

    This study explores complex language in adolescents with specific language impairment (SLI) with the aim of finding out how aspects of language characteristic of typical syntactic development after childhood fare and, in particular, whether there is evidence that individuals with SLI avoid using structures whose syntactic derivation involves…

  15. Impaired Visual Habituation in Adults with ADHD

    Science.gov (United States)

    Massa, Jacqueline; O'Desky, Ilyse H.

    2012-01-01

    Objective: Habituation has an important role in attention. By reducing one's sensitivity to a constant source of stimulation, it frees up attention resources to process new distinct items. Impaired habituation may disrupt sustained attention via inability to modulate the repeated intrusion of irrelevant stimuli. Method: Using Troxler fading, this…

  16. Cognitive impairment in relapsing remitting Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Saška Roškar

    2003-06-01

    Full Text Available The purpose of the study was to identify changes in cognitive abilities that affect patients with relapsing remitting form of multiple sclerosis (MS and to find out which instrument manifests them best. The performance of MS patients was compared to a matched group of healthy people using three neuropsychological tests: Wisconsin card sorting test (WCST, Stroop color and word test and Trail making test (TMT part B. Results on all three tests indicate general cognitive impairments in the group of patients. Compared to the group of healthy people patients with MS exhibited impaired ability of abstract reasoning (WCST, impaired cognitive flexibility and less resistance to irrelevant stimuli (Stroop color and word test, slowed information processing and impaired ability of shifting attention from one symbol to another (TMT. The largest differences between groups occured in Stroop color and word test as well as in TMT. The estimation of cognitive abilities of MS patients is of high importance and sistematicaly observing of changes in those abilities should be considered.

  17. Services for Visually Impaired Adults in Canada.

    Science.gov (United States)

    Magarrell, G.

    1990-01-01

    The article examines the partnership between the Canadian government and nonprofit organizations in delivering rehabilitation services to blind/visually impaired adults. Discussed are legislation, concessions to blind persons, services of the Canadian National Institute for the Blind, special equipment, dog guide schools, consumer groups, and the…

  18. Lighting Up Science for the Visually Impaired.

    Science.gov (United States)

    Billings, Gilbert W.; And Others

    1980-01-01

    Described are activities designed specifically for visually impaired students, demonstrating (1) meiosis, (2) mass, (3) enzyme-substrate reactions, (4) function and relationships of flowering parts. Employed are tactile and auditory learning aids, such as the tape recorder, electric eye, Braille typewriter, textured fabrics, and three-dimensional…

  19. Dual Task Impairments in Vascular Dementia

    Directory of Open Access Journals (Sweden)

    Kate Inasaridze

    2010-01-01

    Full Text Available Several studies have shown that people with Alzheimer's disease (AD demonstrate difficulties in doing two things at once or 'dual-tasking' and that this dual task impairment is insensitive to normal ageing, chronic depression or prodromal conditions like Mild Cognitive Impairment. It is not known, however, if this impairment is specific to AD, or also present in other dementias, such as vascular dementia (VaD. In this study 15 people with VaD, 25 healthy age-matched and 25 healthy young controls were assessed using a paper and pencil dual tasking paradigm and several measures of working and episodic memory. Age had no effect on dual task performance, but the VaD patients demonstrated a significant impairment in dual tasking ability. Performance on the memory measures was instead affected by age with a further deterioration in the VaD patients. Both dual tasking and memory ability were significantly correlated with disease severity, as assessed by the MMSE. These results indicate that performance on the dual task could be a specific indicator of pathological ageing.

  20. Rehabilitation and Visual Impairment: A Human System.

    Science.gov (United States)

    Vander Kolk, Charles J.

    1982-01-01

    The rehabilitation of visually impaired persons can be conceptualized by a human systems approach. This paper explaines seven levels of human systems, related factors, and 10 assumptions that lead to high standards for rehabilitation workers and organizations. The concepts are applied to work with clients and use in rehabilitation agencies.…

  1. Language Learning Impairment in Sequential Bilingual Children

    Science.gov (United States)

    Ebert, Kerry Danahy; Kohnert, Kathryn

    2016-01-01

    We review and synthesize empirical evidence at the intersection of two populations: children with language learning impairment (LLI) and children from immigrant families who learn a single language from birth and a second language beginning in early childhood. LLI is a high incidence disorder that, in recent years, has been referred to by…

  2. Speech and neurology-chemical impairment correlates

    Science.gov (United States)

    Hayre, Harb S.

    2002-05-01

    Speech correlates of alcohol/drug impairment and its neurological basis is presented with suggestion for further research in impairment from poly drug/medicine/inhalent/chew use/abuse, and prediagnosis of many neuro- and endocrin-related disorders. Nerve cells all over the body detect chemical entry by smoking, injection, drinking, chewing, or skin absorption, and transmit neurosignals to their corresponding cerebral subsystems, which in turn affect speech centers-Broca's and Wernick's area, and motor cortex. For instance, gustatory cells in the mouth, cranial and spinal nerve cells in the skin, and cilia/olfactory neurons in the nose are the intake sensing nerve cells. Alcohol depression, and brain cell damage were detected from telephone speech using IMPAIRLYZER-TM, and the results of these studies were presented at 1996 ASA meeting in Indianapolis, and 2001 German Acoustical Society-DEGA conference in Hamburg, Germany respectively. Speech based chemical Impairment measure results were presented at the 2001 meeting of ASA in Chicago. New data on neurotolerance based chemical impairment for alcohol, drugs, and medicine shall be presented, and shown not to fully support NIDA-SAMSHA drug and alcohol threshold used in drug testing domain.

  3. Does Reversal of Asset Impairment Loss Matter? Evidence from China

    Directory of Open Access Journals (Sweden)

    Ming-Lei Chang

    2015-04-01

    Full Text Available The purpose of this research is to investigate whether the reforms of asset impairment regulations affect the provision and functional role of impairment losses and reversals of listed firms in China. The results reveal that listed firms decrease the provision of long-term asset impairments, but increase the provision of current asset impairments and reversals following the implementation of new asset impairment regulations. This research also verifies that listed firms adjust impairment provisions and reversals policy for income smoothing and big-bath purposes. Under different earnings management incentives, this study also finds that special treatment (ST and non-ST firms show different level of accounting policy adjustment.

  4. Impaired GABAergic Neurotransmission in Schizophrenia Underlies Impairments in Cortical Gamma Band Oscillations

    OpenAIRE

    McNally, James M.; McCarley, Robert W.; Brown, Ritchie E.

    2013-01-01

    Impairment of cortical circuit function is increasingly believed to be central to the pathophysiology of schizophrenia (Sz). Such impairments are suggested to result in abnormal gamma band oscillatory activity observed in Sz patients, and likely underlie the psychosis and cognitive deficits linked to this disease. Development of improved therapeutic strategies to enhance functional outcome of Sz patients is contingent upon a detailed understanding of the mechanisms behind the cortical circuit...

  5. Profile of Cognitive Complaints in Vascular Mild Cognitive Impairment and Mild Cognitive Impairment

    OpenAIRE

    Schweizer, Tom A.; Gustavo Saposnik; Corinne E. Fischer; Jenny Gu

    2013-01-01

    Objective. Vascular mild cognitive impairment (VaMCI) is differentiated from mild cognitive impairment (MCI) by the presence of vascular events such as stroke or small vessel disease. Typically, MCI and VaMCI patients present with subjective complaints regarding cognition; however, little is known about the specific nature of these complaints. We aimed to create a profile of subjective cognitive complaints in MCI and VaMCI patients with similar levels of objective cognitive performance. Metho...

  6. Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment

    OpenAIRE

    Westerberg, Carmen E.; Mander, Bryce A.; Florczak, Susan M.; Weintraub, Sandra; Mesulam, M.-Marsel; Zee, Phyllis C.; Paller, Ken A.

    2012-01-01

    Whereas patients with Alzheimer's disease (AD) experience difficulties forming and retrieving memories, their memory impairments may also partially reflect an unrecognized dysfunction in sleep-dependent consolidation that normally stabilizes declarative memory storage across cortical areas. Patients with amnestic mild cognitive impairment (aMCI) exhibit circumscribed declarative memory deficits, and many eventually progress to an AD diagnosis. Whether sleep is disrupted in aMCI and whether sl...

  7. Nutrient Impaired 303(d) Streams for the Pacific Northwest

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — “Under section 303(d) of the 1972 Clean Water Act, states, territories, and authorized tribes are required to develop lists of impaired waters. These impaired...

  8. Find Services for People Who Are Blind or Visually Impaired

    Science.gov (United States)

    ... Find Services for People Who Are Blind or Visually Impaired Category All Advocacy Assessment/Evaluation Audio, Braille or ... Find Services for People Who Are Blind or Visually Impaired Browse All Search Categories About the Directory Request ...

  9. Evaluating Causes of Ecological Impairments in the Estuaries of Ukraine

    Science.gov (United States)

    Ukrainian estuaries have not undergone a systematic evaluation of the causes of ecological impairments caused by anthropogenic contamination. The objective of this evaluation is to use recently developed diagnostic tools to determine the causes of benthic ecological impairments. ...

  10. Auditory Assessment of Visually Impaired Preschoolers: A Team Effort.

    Science.gov (United States)

    Gleason, Deborah

    1984-01-01

    The paper provides an overview of audiological terms and types of hearing impairments to help teachers of visually impaired preschoolers work more effectively with audiologists. Both functional auditory assessment and formal audiometric evaluations are discussed. (Author/CL)

  11. ATTITUDE PARENTS TO EARLY INTERVENTION OF VISUALLY IMPAIRED CHILDREN

    OpenAIRE

    Mira CVETKOVA

    1997-01-01

    For centuries Visually Impaired children have been educated within the high walls of special schools (Loots ET al., 1992). It is only during the last decades that more and more Visually Impaired children were brought up in their own environment:· the integrated education is not a trend anymore, but an educational policy;· The Early Intervention has transferred into approach to young Visually Impaired children.Early Intervention is crucial because the Visually Impairment affects the early deve...

  12. [Working with hearing impairment: an integrated approach].

    Science.gov (United States)

    van Til, Marten J; Kramer, Sophia E; Anema, Johannes R; Goverts, S T Theo

    2016-01-01

    Patients with hearing impairment are more likely to encounter health problems and difficulties at work than their colleagues with normal hearing. This is often not realised by either patients or professionals. In this article we describe three cases that illustrate how working conditions can influence the health of workers with hearing loss. We have implemented a vocational enablement protocol that follows a multidisciplinary approach in order to meet these patients' needs. Due to a mismatch between the demands of a job and an individual's auditory capacities, even a mild hearing impairment can cause serious problems if a patient works in adverse conditions. In addition, in many workplaces the ability to hear well is a safety issue. Professionals have to be aware of both possibilities. Specialized centres offer good facilities and ensure the optimal transfer of insight into the working environment by involving an occupational physician in their team. PMID:27050493

  13. Intrafamilial phenotypic variability of Specific Language Impairment.

    Science.gov (United States)

    Bartha-Doering, Lisa; Regele, Sabrina; Deuster, Dirk; Seidl, Rainer; Bogdanova, Nadja; Röpke, Albrecht; Wieacker, Peter; Am Zehnhoff-Dinnesen, Antoinette

    2016-08-01

    We investigated language functions in 32 members of a four generation family with several members affected by Specific Language Impairment with an extensive language test battery in order to determine the prevalence, overlap, and homogeneity of linguistic deficits within one pedigree. In sum, one fourth of all family members tested fulfilled the criteria of Specific Language Impairment. Despite of some similarities in language abilities, different combinations of language deficits were observed, and individual language profiles varied substantially. Thus, though there is a high prevalence of language deficits in this family which raises the likelihood of a genetic origin of these deficits, and though all affected study participants displayed selective linguistic deficits with normal non-verbal functioning, language testing showed considerable variance in overlap and homogeneity of linguistic deficits. Thus, even in one genetic population, an underlying linguistic disorder manifests itself in different language abilities to a variant degree. PMID:27388785

  14. Theophylline antagonizes diazepam-induced psychomotor impairment.

    Science.gov (United States)

    Henauer, S A; Hollister, L E; Gillespie, H K; Moore, F

    1983-01-01

    Eight healthy men received an oral dose of 0.25 mg/kg diazepam followed 40 min later by an intravenous infusion of 100 ml physiological sodium chloride solution, with or without 4.4 mg/kg theophylline. Psychomotor function was assessed after each blood sampling up to 5 h post-infusion. Thirty min after diazepam psychomotor performance measured by Card Sorting test and Digit Symbol Substitution test was impaired and subjects felt sleepy and could think less clearly (two factors of the Clyde Mood Scale). Theophylline antagonized the diazepam-induced impairment statistically significantly for up to 5 h and subjects felt less tense and less apprehensive (State Anxiety Inventory). Since pharmacokinetic parameters of diazepam seemed not to be different after theophylline, interaction at receptor level can be assumed. PMID:6662173

  15. A case of impaired shape integration

    DEFF Research Database (Denmark)

    Gerlach, Christian; Marstrand, Lisbet; Habekost, Thomas; Gade, Anders

    2005-01-01

    We describe a patient, HE, who was left with a remarkably selective deficit in intermediate vision following an infarct in the right occipito-temporal region. Thus, HE was able to group elements by colour and proximity but impaired in grouping based on similarity in shape. This finding supports the...... notion that grouping may be divided into two general steps: (i) element clustering and (ii) shape configuration, with the latter operation being impaired in HE. As opposed to previous cases with shape integration deficits, HE was able to name objects accurately. Initially, this might suggest that shape...... integration is not a prerequisite for normal object naming. However, on more demanding tests of visual object recognition, HE's performance deteriorated, with her performance being inversely related to the demand placed on integration of local elements into more elaborate shape descriptions. From this we...

  16. Evacuation of People with Visual Impairments

    DEFF Research Database (Denmark)

    Sørensen, Janne Gress

    able-bodied. This is expected since the model is based on data for this group. Likewise, the theoretical model is conservative estimate for the hearing impaired participants moving on horizontal planes. For all tested subpopulations the walking speed decreased with increasing person density, but the...... fire for this segment of the population is larger than for able-bodied people. It can therefore be questioned whether our buildings provide a sufficient safety level for this group of people. The aim of the PhD Study is to increase knowledge and data on evacuation characteristics of vulnerable people...... and with a special focus on blind and visually impaired people. An experimental program is designed to obtain data on walking speeds horizontally and descending stairs, interaction between participants and their interaction with the building environment. Experiments are conducted in different...

  17. Rehabilitation of impaired speech function (dysarthria, dysglossia

    Directory of Open Access Journals (Sweden)

    Schröter-Morasch, Heidrun

    2005-09-01

    Full Text Available Speech disorders can result (1 from sensorimotor impairments of articulatory movements = dysarthria, or (2 from structural changes of the speech organs, in adults particularly after surgical and radiochemical treatment of tumors = dysglossia. The decrease of intelligibility, a reduced vocal stamina, the stigmatization of a conspicuous voice and manner of speech, the reduction of emotional expressivity all mean greatly diminished quality of life, restricted career opportunities and diminished social contacts. Intensive therapy based on the pathophysiological facts is absolutely essential: Functional exercise therapy plays a central role; according to symptoms and their progression it can be complemented with prosthetic and surgical approaches. In severe cases communicational aids have to be used. All rehabilitation measures have to take account of frequently associated disorders of body motor control and/or impairment of cognition and behaviour.

  18. Impaired inhibitory control in recreational cocaine users.

    Directory of Open Access Journals (Sweden)

    Lorenza S Colzato

    Full Text Available Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult recreational users and in a cocaine-free-matched sample controlled for age, race, gender distribution, level of intelligence, and alcohol consumption. Response inhibition and response execution were measured by a stop-signal paradigm. Results show that users and non users are comparable in terms of response execution but users need significantly more time to inhibit responses to stop-signals than non users. Interestingly, the magnitude of the inhibitory deficit was positively correlated with the individuals lifetime cocaine exposure suggesting that the magnitude of the impairment is proportional to the degree of cocaine consumed.

  19. Parkinson's disease associated with impaired oxidative phosphorylation

    International Nuclear Information System (INIS)

    Parkinson's disease may be due to primary or secondary oxidative phosphorylation (OXPHOS) defects. In a 76-year-old man with Parkinson's disease since 1992, slightly but recurrently elevated creatine phosphokinase, recurrently elevated blood glucose, thickening of the left ventricular myocardium, bifascicular block and hypacusis were found. Cerebral MRI showed atrophy, periventricular demyelination, multiple, disseminated, supra- and infratentorial lacunas, and haemosiderin deposits in both posterior horns. Muscle biopsy showed typical features of an OXPHOS defect. Whether the association of Parkinson's disease and impaired OXPHOS was causative or coincidental remains unknown. Possibly, the mitochondrial defect acted as an additional risk factor for Parkinson's disease or the OXPHOS defect worsened the preexisting neurological impairments by a cumulative or synergistic mechanism. In conclusion, this case shows that Parkinson's disease may be associated with a mitochondrially or nuclearly encoded OXPHOS defect, manifesting as hypacusis, myopathy, axonal polyneuropathy, cardiomyopathy and recurrent subclinical ischaemic strokes and haemorrhages. (orig.)

  20. Image and Video for Hearing Impaired People

    Directory of Open Access Journals (Sweden)

    Aran Oya

    2007-01-01

    Full Text Available We present a global overview of image- and video-processing-based methods to help the communication of hearing impaired people. Two directions of communication have to be considered: from a hearing person to a hearing impaired person and vice versa. In this paper, firstly, we describe sign language (SL and the cued speech (CS language which are two different languages used by the deaf community. Secondly, we present existing tools which employ SL and CS video processing and recognition for the automatic communication between deaf people and hearing people. Thirdly, we present the existing tools for reverse communication, from hearing people to deaf people that involve SL and CS video synthesis.

  1. Image and Video for Hearing Impaired People

    Directory of Open Access Journals (Sweden)

    Thomas Burger

    2008-04-01

    Full Text Available We present a global overview of image- and video-processing-based methods to help the communication of hearing impaired people. Two directions of communication have to be considered: from a hearing person to a hearing impaired person and vice versa. In this paper, firstly, we describe sign language (SL and the cued speech (CS language which are two different languages used by the deaf community. Secondly, we present existing tools which employ SL and CS video processing and recognition for the automatic communication between deaf people and hearing people. Thirdly, we present the existing tools for reverse communication, from hearing people to deaf people that involve SL and CS video synthesis.

  2. The Impact of Visual Impairment on Perceived School Climate

    Science.gov (United States)

    Schade, Benjamin; Larwin, Karen H.

    2015-01-01

    The current investigation examines whether visual impairment has an impact on a student's perception of the school climate. Using a large national sample of high school students, perceptions were examined for students with vision impairment relative to students with no visual impairments. Three factors were examined: self-reported level of…

  3. Attentional Processes in Young Children with Congenital Visual Impairment

    Science.gov (United States)

    Tadic, Valerie; Pring, Linda; Dale, Naomi

    2009-01-01

    The study investigated attentional processes of 32 preschool children with congenital visual impairment (VI). Children with profound visual impairment (PVI) and severe visual impairment (SVI) were compared to a group of typically developing sighted children in their ability to respond to adult directed attention in terms of establishing,…

  4. Grief and Needs of Adults with Acquired Visual Impairments

    Science.gov (United States)

    Murray, Shirley A.; McKay, Robert C.; Nieuwoudt, Johan M.

    2010-01-01

    This report aims to illuminate the complex phenomenon of grief and the needs experienced throughout the time course of their impairments by adults with acquired visual impairments. The study applied a phenomenological research strategy using 10 case studies of South African adults, visually impaired within and beyond six years. Qualitative…

  5. Effective Classroom Adaptations for Students with Visual Impairments.

    Science.gov (United States)

    Cox, Penny R.; Dykes, Mary K.

    2001-01-01

    This article discusses strategies for including students with visual impairments in general education settings. It explains categories of visual impairments and how students with visual impairments learn. Auditory learning and visual learning accommodations are addressed, and checklists for orientation and mobility adaptations, and for classroom…

  6. Annual research review : conceptualising functional impairment in children and adolescents

    NARCIS (Netherlands)

    Rapee, R.M.; Bogels, S.M.; van der Sluis, Cathy .M.; Craske, M.G.; Ollendick, T.

    2012-01-01

    Functional impairment is a key factor in the clinical importance of mental health problems in children. Yet, the nature of impairment and criteria for defining and assessing impairment in childhood disorders has been surprisingly overlooked in much of the literature. The current article examines the

  7. Specific language impairment as systemic developmental disorders

    OpenAIRE

    Parisse, Christophe; Maillart, Christelle

    2009-01-01

    Specific Language Impairment (SLI) is a disorder characterised by slow, abnormal language development.Most children with this disorder do not present any other cognitive or neurological deficits. Thereare many different pathological developmental profiles and switches from one profile to another oftenoccur. An alternative would be to consider SLI as a generic name covering three developmental languagedisorders: developmental verbal dyspraxia, linguistic dysphasia, and pragmatic language impai...

  8. Impaired decisional impulsivity in pathological videogamers

    OpenAIRE

    Irvine, Michael A.; Worbe, Yulia; Bolton, Sorcha; Harrison, Neil A.; Bullmore, Edward T.; Voon, Valerie

    2013-01-01

    Abstract Background Pathological gaming is an emerging and poorly understood problem. Impulsivity is commonly impaired in disorders of behavioural and substance addiction, hence we sought to systematically investigate the different subtypes of decisional and motor impulsivity in a well-defined pathological gaming cohort. Methods Fifty-two pathological gaming subjects and age-, gender- and IQ-matched healthy volunteers were tested on decisional impulsivity (Information Sampling ...

  9. Cognitive impairments in patients with brain injury

    OpenAIRE

    Vladimir Vladimirovich Zakharov; E. A. Drozdova

    2013-01-01

    The paper gives the data of Russian and foreign authors and the results of this paper authors’ investigation of higher cerebral functions in patients who have sustained brain injury (BI). It shows their high prevalence, the predominance of cognitive impairments (CI) over neurological disorders in patients with mild and moderate injury, presents their quantitative and qualitative features (a preponderance of focal symptoms in severe injury and neurodynamic disorders in mild injury), describes ...

  10. Visualization Learning for Visually Impaired People

    OpenAIRE

    Salamin, Patrick; Thalmann, Daniel; Vexo,Frederic

    2007-01-01

    Virtual Environments (VE) are mainly visual experiments that exclude visually impaired people. In this paper we present an application that should allow almost everybody to ``see'' or at least to perceive 3D shapes. We will first describe the mandatory aspects of such an application, the tests we made and finally conclude by the results we obtained with geometrically basic shapes that are very promising.

  11. Type 2 diabetes mellitus and exercise impairment

    OpenAIRE

    Reusch, Jane E. B.; Bridenstine, Mark; Regensteiner, Judith G

    2013-01-01

    Limitations in physical fitness, a consistent finding in individuals with both type I and type 2 diabetes mellitus, correlate strongly with cardiovascular and all-cause mortality. These limitations may significantly contribute to the persistent excess cardiovascular mortality affecting this group. Exercise impairments in VO2 peak and VO2 kinetics manifest early on in diabetes, even with good glycemic control and in the absence of clinically apparent complications. Subclinical cardiac dysfunct...

  12. Impaired glucose tolerance in acute pancreatitis

    OpenAIRE

    Kikuta, Kazuhiro; Masamune, Atsushi; Shimosegawa, Tooru

    2015-01-01

    Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. In spite of the pivotal role of the endocrine pancreas in glucose metabolism, the impact of impaired glucose tolerance on AP has not been fully elucidated. A meta-analysis of seven observational studies showed that type 2 diabetes mellitus (DM) was associated with an increased risk of AP. The increased risk of AP shown in the meta-analysis was independent of hyperlipidemia, alcohol use and gallstones. Anti-diab...

  13. Impaired Fibrinolysis in the Antiphospholipid Syndrome

    OpenAIRE

    Krone, Katie A.; Allen, Kristi L.; McCrae, Keith R

    2010-01-01

    The antiphospholipid syndrome (APS) is characterized by venous and/or arterial thrombosis, or recurrent fetal loss, in the presence of antiphospholipid antibodies (APL). The pathogenesis of APS is multifaceted and involves numerous mechanisms including activation of endothelial cells, monocytes, and/or platelets; inhibition of natural anticoagulant pathways such as protein C, tissue factor inhibitor, and annexin A5; activation of the complement system; and impairment of the fibrinolytic syste...

  14. Signal processing for RF circuit impairment mitigation

    CERN Document Server

    Huang, Xinping; Leung, Henry

    2014-01-01

    A wireless communication system employs a radio frequency (RF) wave to transmit information bearing signals. In modern digital communication systems, sophisticated modulation techniques are developed to modulate information onto an RF carrier waveform, so as to transmit more information.This new book presents signal processing techniques for reducing impairments of analog and RF circuits in wireless communications systems. Engineers, researchers, and students will find full coverage of the topic, including vector modulators, power amplifiers, vector demodulators, group delay distortion in anal

  15. A Neurocomputational Model of Impaired Imitation

    OpenAIRE

    Petreska, B.; Billard, A.

    2006-01-01

    This abstract addresses the question of human imitation through convergent evidence from neuroscience, using tools from machine learning. In particular, we consider a deficit in imitation of meaningless gestures (i.e., hand postures relative to the head) following callosal brain lesion (i.e., disconnected hemispheres). We base our work on the rational that looking at how imitation in apraxic patients is impaired can unveil its underlying neural principles. We ground the functional architectur...

  16. Specific affect regulation impairments in major depression

    OpenAIRE

    Brockmeyer, Timo

    2012-01-01

    Impairments in affect regulation as well as cognitive reactivity have been considered to play important roles in the development, maintenance, and recurrence of major depressive disorder (MDD). However, there is a lack of studies investigating, (a) whether certain difficulties in emotion regulation are specific for MDD, (b) whether certain meta-mood beliefs are associated with an increased risk for MDD, and (c) whether reduced abilities to engage in mood-incongruent information processing and...

  17. Cumulative life course impairment in vitiligo.

    Science.gov (United States)

    Krüger, Christian; Schallreuter, Karin Uta

    2013-01-01

    Vitiligo is an acquired, idiopathic skin disease characterized by the mostly progressive loss of the inherited skin color leading to white patches and in some cases to total depigmentation. The course of this ancient disease is still unknown. The worldwide prevalence range is 0.5-1%. The disease burden includes stigmatization, depression, impaired quality of life, lack of self-confidence, embarrassment and self-consciousness. To the best of our knowledge, the extent to which this chronic disease may exert an influence upon the life course of affected individuals has, to date, not been investigated. The material presented herein is the result of an accurate analysis of published literature. Moreover, we included our own data collected in two studies. To apply the concept of cumulative life course impairment in vitiligo, we looked at possible trigger factors, role of patient's age and the age at disease onset, disease duration and stigmatization. Stigmatization had the strongest impact. It is common in patients with an early disease onset, often leading to other disturbances. Our data revealed that older patients or those with a disease onset later in life adjust better to this chronic skin disorder and that they are less socially avoidant. However, long disease duration can also lead to impaired quality of life and obsession, while this group seems to be less depressed or embarrassed. Results from our own work with peer groups of these patients strongly support a positive long-lasting effect of treatment on quality of life of children, adolescents and adults. To which extent vitiligo may contribute to a cumulative life course impairment remains to be shown. PMID:23796814

  18. Impairment of Proprioception After Whiplash Injury

    OpenAIRE

    Uremović, Melita; Cvijetić, Selma; Bošnjak Pašić, Marija; Šerić, Vesna; Vidrih, Branka; Demarin, Vida

    2007-01-01

    Whiplash injury usually occurs in traffic accidents. Persons experienced this injury might have an impairment of proprioception clinically expressed as inability to determine the exact position of their heads. The aim of this study was to examine the loss of proprioception in people who had a whiplash injury. The study included 60 subjects with cervical spine injury, aged 20 to 50 years and 60 healthy volunteers matched by sex and age. The instrument used for cervical spine mobili...

  19. Metformin promotes isolated rat liver mitochondria impairment

    OpenAIRE

    Carvalho, Cristina; Correia, Sónia; Santos, Maria,; Seiça, Raquel; Oliveira, Catarina; Moreira, Paula

    2008-01-01

    Abstract Metformin, a drug widely used in the treatment of type 2 diabetes, has recently received attention due to the new and contrasting findings regarding its effects on mitochondrial function. In the present study, we evaluated the effect of metformin in isolated rat liver mitochondria status. We observed that metformin concentrations =8 mM induce an impairment of the respiratory chain characterized by a decrease in RCR and state 3 respiration. However, only metformin concentrations =10 ...

  20. Haemostasis impairment in bitches with pyometra

    OpenAIRE

    Plavec Tanja; Celinšek Barbara; Dolinar Kristina; Pečar J.; Nemec Alenka; Butinar Janoš

    2006-01-01

    It is well known that pyometra syndrome with endotoxemia and/or sepsis in bitches may impair different organ systems and functions including haemostasis, which may considerably influence the outcome if overlooked or underestimated. The present clinical study was carried out on thirty-seven clinical patients admitted to the Clinic for Small Animal Medicine and Surgery at the Veterinary Faculty in Ljubljana, Slovenia. Preoperative diagnosis was based on clinical signs, haematology results and u...

  1. Impaired picture recognition in transient epileptic amnesia.

    Science.gov (United States)

    Dewar, Michaela; Hoefeijzers, Serge; Zeman, Adam; Butler, Christopher; Della Sala, Sergio

    2015-01-01

    Transient epileptic amnesia (TEA) is an epileptic syndrome characterized by recurrent, brief episodes of amnesia. Transient epileptic amnesia is often associated with the rapid decline in recall of new information over hours to days (accelerated long-term forgetting - 'ALF'). It remains unknown how recognition memory is affected in TEA over time. Here, we report a systematic study of picture recognition in patients with TEA over the course of one week. Sixteen patients with TEA and 16 matched controls were presented with 300 photos of everyday life scenes. Yes/no picture recognition was tested 5min, 2.5h, 7.5h, 24h, and 1week after picture presentation using a subset of target pictures as well as similar and different foils. Picture recognition was impaired in the patient group at all test times, including the 5-minute test, but it declined normally over the course of 1week. This impairment was associated predominantly with an increased false alarm rate, especially for similar foils. High performance on a control test indicates that this impairment was not associated with perceptual or discrimination deficits. Our findings suggest that, at least in some TEA patients with ALF in verbal recall, picture recognition does not decline more rapidly than in controls over 1week. However, our findings of an early picture recognition deficit suggest that new visual memories are impoverished after minutes in TEA. This could be the result of deficient encoding or impaired early consolidation. The early picture recognition deficit observed could reflect either the early stages of the process that leads to ALF or a separable deficit of anterograde memory in TEA. Lastly, our study suggests that at least some patients with TEA are prone to falsely recognizing new everyday visual information that they have not in fact seen previously. This deficit, alongside their ALF in free recall, likely affects everyday memory performance. PMID:25506793

  2. Quantitative analysis of brain metabolites in patients,with non-dementia vascular cognitive impairment and mild cognitive impairment

    Institute of Scientific and Technical Information of China (English)

    刘艳艳

    2013-01-01

    Objective To investigate metabolite changes in the brain of patients with non-dementia vascular cognitive impairment(VCIND) and mild cognitive impairment(MCI) using magnetic resonance spectroscopy(MRS)

  3. Behavioral symptoms related to cognitive impairment

    Directory of Open Access Journals (Sweden)

    Dillon C

    2013-09-01

    Full Text Available Carol Dillon,1 Cecilia M Serrano,1 Diego Castro,1 Patricio Perez Leguizamón,1 Silvina L Heisecke,1,2 Fernando E Taragano1 1CEMIC (Centro de Educación Médica e Investigaciones Clínicas University Institute, 2CONICET (Consejo Nacional de Investigaciones Cientificas y Técnicas, Buenos Aires, Argentina Abstract: Neuropsychiatric symptoms (NPS are core features of Alzheimer's disease and related dementias. On one hand, behavioral symptoms in patients with mild cognitive impairment (MCI can indicate an increased risk of progressing to dementia. On the other hand, mild behavioral impairment (MBI in patients who usually have normal cognition indicates an increased risk of developing dementia. Whatever the cause, all dementias carry a high rate of NPI. These symptoms can be observed at any stage of the disease, may fluctuate over its course, are a leading cause of stress and overload for caregivers, and increase rates of hospitalization and early institutionalization for patients with dementia. The clinician should be able to promptly recognize NPI through the use of instruments capable of measuring their frequency and severity to support diagnosis, and to help monitor the treatment of behavioral symptoms. The aims of this review are to describe and update the construct ‘MBI’ and to revise the reported NPS related to prodromal stages of dementia (MCI and MBI and dementia stages of Alzheimer’s disease and frontotemporal lobar degeneration. Keywords: behavioral or neuropsychiatric symptoms, cognitive impairment, dementia

  4. OPHTHALMOLOGIC ABNORMALITIES IN CHILDREN WITH IMPAIRED HEARING

    Directory of Open Access Journals (Sweden)

    Inderjit

    2014-02-01

    Full Text Available AIM: To determine the nature of ophthalmologic abnormalities in severe and profound grades of hearing impaired children and to treat visual impairment if any at the earliest . MATERIAL AND METHODS: Study was conducted on100 children in the age group of 5 - 14 years with severe and profound hearing loss visiting outpatient department of Ram Lal Eye and ENT hospital Govt. Medical College Amritsar and subjected to detailed ophthalmological examination. RESULTS: 100 children in the age group 5 - 14 years with hearing impairment were enrolled for t he study , 68 had profound and 32 had severe hearing loss . Visual disorders were found to be as high as 71%. Highest percentage was seen in children aged 7 years. Majority of them (50% had refractive error. Out of these 50 children , 28(56% had myopia , 10 (20% hypermetropia and 12(24% had astigmatism . The other ophthalmic abnormalities in our study were conjunctivitis 14(19.71% , fundus abnormalities and squint 11(15.49% , blepharitis 5 (7.04% , vitamin A deficiency 6 (8.04% , amblyopia 8 (11.26% , pupil disorder 3 (4.22% , cataract 3 (4.22% and heterochromia iridis 7 (9.85%. CONCLUSION : The high prevalence of ophthalmic abnormalities in deaf children mandate screening them for possible ophthalmic abnormalities. Early diagnosis and correction of visual d isturbances would go a long way in social and professional performance of these children.

  5. Cognitive impairment, genomic instability and trace elements.

    Science.gov (United States)

    Meramat, A; Rajab, N F; Shahar, S; Sharif, R

    2015-01-01

    Cognitive impairments are often related to aging and micronutrient deficiencies. Various essential micronutrients in the diet are involved in age-altered biological functions such as, zinc, copper, iron, and selenium that play pivotal roles either in maintaining and reinforcing the antioxidant performances or in affecting the complex network of genes (nutrigenomic approach) involved in encoding proteins for biological functions. Genomic stability is one of the leading causes of cognitive decline and deficiencies or excess in trace elements are two of the factors relating to it. In this review, we report and discuss the role of micronutrients in cognitive impairment in relation to genomic stability in an aging population. Telomere integrity will also be discussed in relation to aging and cognitive impairment, as well as, the micronutrients related to these events. This review will provide an understanding on how these three aspects can relate with each other and why it is important to keep a homeostasis of micronutrients in relation to healthy aging. Micronutrient deficiencies and aging process can lead to genomic instability. PMID:25560816

  6. Stroke injury, cognitive impairment and vascular dementia☆

    Science.gov (United States)

    Kalaria, Raj N.; Akinyemi, Rufus; Ihara, Masafumi

    2016-01-01

    The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes. Current evidence suggests that 25–30% of ischaemic stroke survivors develop immediate or delayed vascular cognitive impairment (VCI) or vascular dementia (VaD). Dementia after stroke injury may encompass all types of cognitive disorders. States of cognitive dysfunction before the index stroke are described under the umbrella of pre-stroke dementia, which may entail vascular changes as well as insidious neurodegenerative processes. Risk factors for cognitive impairment and dementia after stroke are multifactorial including older age, family history, genetic variants, low educational status, vascular comorbidities, prior transient ischaemic attack or recurrent stroke and depressive illness. Neuroimaging determinants of dementia after stroke comprise silent brain infarcts, white matter changes, lacunar infarcts and medial temporal lobe atrophy. Until recently, the neuropathology of dementia after stroke was poorly defined. Most of post-stroke dementia is consistent with VaD involving multiple substrates. Microinfarction, microvascular changes related to blood–brain barrier damage, focal neuronal atrophy and low burden of co-existing neurodegenerative pathology appear key substrates of dementia after stroke injury. The elucidation of mechanisms of dementia after stroke injury will enable establishment of effective strategy for symptomatic relief and prevention. Controlling vascular disease risk factors is essential to reduce the burden of cognitive dysfunction after stroke. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID:26806700

  7. Stroke injury, cognitive impairment and vascular dementia.

    Science.gov (United States)

    Kalaria, Raj N; Akinyemi, Rufus; Ihara, Masafumi

    2016-05-01

    The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes. Current evidence suggests that 25-30% of ischaemic stroke survivors develop immediate or delayed vascular cognitive impairment (VCI) or vascular dementia (VaD). Dementia after stroke injury may encompass all types of cognitive disorders. States of cognitive dysfunction before the index stroke are described under the umbrella of pre-stroke dementia, which may entail vascular changes as well as insidious neurodegenerative processes. Risk factors for cognitive impairment and dementia after stroke are multifactorial including older age, family history, genetic variants, low educational status, vascular comorbidities, prior transient ischaemic attack or recurrent stroke and depressive illness. Neuroimaging determinants of dementia after stroke comprise silent brain infarcts, white matter changes, lacunar infarcts and medial temporal lobe atrophy. Until recently, the neuropathology of dementia after stroke was poorly defined. Most of post-stroke dementia is consistent with VaD involving multiple substrates. Microinfarction, microvascular changes related to blood-brain barrier damage, focal neuronal atrophy and low burden of co-existing neurodegenerative pathology appear key substrates of dementia after stroke injury. The elucidation of mechanisms of dementia after stroke injury will enable establishment of effective strategy for symptomatic relief and prevention. Controlling vascular disease risk factors is essential to reduce the burden of cognitive dysfunction after stroke. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID:26806700

  8. Non-Word Repetition Impairment in Autism and Specific Language Impairment: Evidence for Distinct Underlying Cognitive Causes

    Science.gov (United States)

    Williams, David; Payne, Heather; Marshall, Chloe

    2013-01-01

    Language-impaired individuals with autism perform poorly on tests such as non-word repetition that are sensitive clinical markers of specific language impairment (SLI). This has fuelled the theory that language impairment in autism represents a co-morbid SLI. However, the underlying cause of these deficits may be different in each disorder. In a…

  9. A Comparison of Social Skills in Turkish Children with Visual Impairments, Children with Intellectual Impairments and Typically Developing Children

    Science.gov (United States)

    Ozkubat, Ufuk; Ozdemir, Selda

    2014-01-01

    The purpose of this study was to compare the social skills of five groups of children: children with visual impairments attending inclusive education schools, children with visual impairments attending schools for the blind, children with intellectual impairments attending inclusive education schools, children with intellectual impairments…

  10. The effect of hearing impairment on educational achievement of hearing-impaired students

    Directory of Open Access Journals (Sweden)

    Ali Asghar Kakojoibari

    2014-06-01

    Full Text Available Background and Aim: Hearing is one of the most vital sensational abilities. Learning, which is the most basic ability for human compatibility to mental development, is affected by hearing ability. The main goal of this article was to review the effect of hearing impairment on educational achievement of hearing-impaired students, especially in the field of basic learning skills (reading, writing, and mathematics.Methods: In this article, the researches on the effect of hearing impairment on educational achievement were reviewed. There were 37 articles extracted from different databases such as Iran Medex, Scopus, PubMed, Magiran, Iran Journal, Google Scholar, and 12 credible books published from 1944 to 2013. In order to search in these databases, educational achievement and other related keywords were used.Conclusion: Hearing impairment affects listening skills, which is a mental process and is known as the first lingual skill. Subsequently, other lingual skills and learning abilities like educational achievement are affected as well. In order to decrease the educational gap in hearing-impaired students, it is very important to interfere in early stages and use of presentation methods to improve lingual skills in educational system.

  11. Evaluation of packet loss impairment on streaming video

    Institute of Scientific and Technical Information of China (English)

    RUI Hua-xia; LI Chong-rong; QIU Sheng-ke

    2006-01-01

    Video compression technologies are essential in video streaming application because they could save a great amount of network resources. However compressed videos are also extremely sensitive to packet loss which is inevitable in today's best effort IP network. Therefore we think accurate evaluation of packet loss impairment on compressed video is very important. In this work, we develop an analytic model to describe these impairments without the reference of the original video (NR) and propose an impairment metric based on the model, which takes into account both impairment length and impairment strength. To evaluate an impaired frame or video, we design a detection and evaluation algorithm (DE algorithm) to compute the above metric value. The DE algorithm has low computational complexity and is currently being implemented in the real-time monitoring module of our HDTV over IP system. The impairment metric and DE algorithm could also be used in adaptive system or be used to compare diffeient error concealment strategies.

  12. Does Visual Impairment Affect Mobility Over Time? The Salisbury Eye Evaluation Study

    OpenAIRE

    Swenor, Bonnielin K.; Muñoz, Beatriz; Sheila K West

    2013-01-01

    Longitudinal analyses found visually impaired older adults were more likely to report mobility disability than their nonvisually impaired counterparts. But mobility disability trajectories were not steeper in the visually impaired than in the nonvisually impaired over the 8-year study.

  13. Incidence and Risk Factors for Cognitive Impairment No Dementia and Mild Cognitive Impairment in African Americans

    OpenAIRE

    Unverzagt, Frederick W.; Ogunniyi, Adesola; Taler, Vanessa; Gao, Sujuan; Lane, Ms. Kathleen A.; Baiyewu, Olusegun; Gureje, Oye; Smith-Gamble, Valerie; Hake, Ann; Hendrie, Hugh C.; Hall, Kathleen S.

    2011-01-01

    The aim of this study was to estimate the age-specific incidence of cognitive impairment, no dementia and mild cognitive impairment (CIND/MCI) in a large, community-based sample of older African Americans in Indianapolis, IN. A longitudinal, prospective, two-stage design was used with follow-up assessments 2 and 5 years after the baseline. A total of 1668 participants completed the 2-year follow-up and a total of 1255 participants completed the 5-year follow-up. The person–years method was us...

  14. Endocrine disruptors and childhood social impairment.

    Science.gov (United States)

    Miodovnik, Amir; Engel, Stephanie M; Zhu, Chenbo; Ye, Xiaoyun; Soorya, Latha V; Silva, Manori J; Calafat, Antonia M; Wolff, Mary S

    2011-03-01

    Prenatal exposure to endocrine disruptors has the potential to impact early brain development. Neurodevelopmental toxicity in utero may manifest as psychosocial deficits later in childhood. This study investigates prenatal exposure to two ubiquitous endocrine disruptors, the phthalate esters and bisphenol A (BPA), and social behavior in a sample of adolescent inner-city children. Third trimester urines of women enrolled in the Mount Sinai Children's Environmental Health Study between 1998 and 2002 (n=404) were analyzed for phthalate metabolites and BPA. Mother-child pairs were asked to return for a follow-up assessment when the child was between the ages of 7 and 9 years. At this visit, mothers completed the Social Responsiveness Scale (SRS) (n=137), a quantitative scale for measuring the severity of social impairment related to Autistic Spectrum Disorders (ASD) in the general population. In adjusted general linear models increasing log-transformed low molecular weight (LMW) phthalate metabolite concentrations were associated with greater social deficits (β=1.53, 95% CI 0.25-2.8). Among the subscales, LMWP were also associated with poorer Social Cognition (β=1.40, 95% CI 0.1-2.7); Social Communication (β=1.86, 95% CI 0.5-3.2); and Social Awareness (β=1.25, 95% CI 0.1-2.4), but not for Autistic Mannerisms or Social Motivation. No significant association with BPA was found (β=1.18, 95% CI -0.75, 3.11). Prenatal phthalate exposure was associated with childhood social impairment in a multiethnic urban population. Even mild degrees of impaired social functioning in otherwise healthy individuals can have very important adverse effects over a child's lifetime. These results extend our previous finding of atypical neonatal and early childhood behaviors in relation to prenatal phthalate exposure. PMID:21182865

  15. Resilience and vision impairment in older people.

    Science.gov (United States)

    Thetford, Clare; Bennett, Kate M; Hodge, Suzanne; Knox, Paul C; Robinson, Jude

    2015-12-01

    Some people fare better than others when faced with adversity; they appear to be more 'resilient'. This article explores the concept of resilience in the context of vision impairment using two linked sets of narrative interview data from 2007 to 2010. Three case studies were analysed in detail using a framework approach based upon a social-ecological model of resilience and vision impairment. Within the model a range of assets and resources are identified which influence an individual's capacity for resilience. A set of criteria were used to establish the extent to which each individual appeared to be resilient at each point in time. Analysis revealed that it is not merely the presence or absence of individual, social, and community resources - but how these resources interact with each other - that influences resilience and can create a risk to wellbeing. To possess only some of these resources is not sufficient; there is a co-dependency between these resources which requires the presence of other resources for resilience to be achieved. Resilience is not a fixed state; individuals can become more or less resilient as their circumstances and resources change over time. We suggest that the concept of resilience has much to offer the field of vision impairment as it allows the identification of enablers as well as areas of barriers to improving people's health and wellbeing and suggests further opportunities for service providers to engage with clients, even those who appear to be supported, as people's social, economic and emotional landscapes continue to change over time, rather than identifying deficit. PMID:26568213

  16. A potential source of hearing impairment; headphones

    International Nuclear Information System (INIS)

    Technological expansions have been observed in recent years for portable devices with hi-fi audio playback capability such as MP4 players, multimedia phones and hand-held game consoles. Usually these devices are used with headphones; therefore the noise levels of different headphones are of particular relevance. Despite of its several benefits, noise levels can be quite high and may cause hearing impairment. In this research, different headphones were selected to check noise levels at varying volumes. It was found in majority of cases that noise levels ranged from 75dB to 85 dB; surpassing the NEQ's and OSHA standard values. (author)

  17. Sonar bat for visually impaired people

    OpenAIRE

    Pedrero Rodríguez, Mauro

    2013-01-01

    Visually impaired people have many difficulties when traveling because it is impossible for them to detect obstacles that stand in their way. Bats instead of using the sight to detect these obstacles use a method based on ultrasounds, as their sense of hearing is much more developed than that of sight. The aim of the project is to design and build a device based on the method used by the bats to detect obstacles and transmit this information to people with vision problems to improve the...

  18. Cognitive impairments in patients with brain injury

    Directory of Open Access Journals (Sweden)

    Vladimir Vladimirovich Zakharov

    2013-01-01

    Full Text Available The paper gives the data of Russian and foreign authors and the results of this paper authors’ investigation of higher cerebral functions in patients who have sustained brain injury (BI. It shows their high prevalence, the predominance of cognitive impairments (CI over neurological disorders in patients with mild and moderate injury, presents their quantitative and qualitative features (a preponderance of focal symptoms in severe injury and neurodynamic disorders in mild injury, describes the predictors of their course and prognosis (the degree of injury is one of the most important predictors, and discusses current trends in the medical correction of detected abnormalities.

  19. What Causes Specific Language Impairment in Children?

    OpenAIRE

    Bishop, Dorothy V. M.

    2006-01-01

    Specific language impairment (SLI) is diagnosed when a child's language development is deficient for no obvious reason. For many years, there was a tendency to assume that SLI was caused by factors such as poor parenting, subtle brain damage around the time of birth, or transient hearing loss. Subsequently it became clear that these factors were far less important than genes in determining risk for SLI. A quest to find “the gene for SLI” was undertaken, but it soon became apparent that no sin...

  20. Residual impairment after lower extremity fracture

    DEFF Research Database (Denmark)

    Faergemann, C; Frandsen, P A; Röck, N D

    1998-01-01

    2.7 pretraumatically and 8.7 6 months posttraumatically. Major deficits in range of motion was observed, especially in the ankle joint. Additionally, loss of muscle strength was observed in the thigh and calf muscles in one fourth of the patients. Only low levels of residual pain were reported after...... functional status before the injury. Additionally, three major aspects of impairments were measured 6 months after the fractures: range of motion, muscle strength, and pain. Most patients had a significantly higher SIP score 6 months after the fracture(s) than pretraumatically. The mean overall SIP score was...

  1. Mild cognitive impairment is becoming more psychosocial.

    Science.gov (United States)

    Verhey, Frans; de Vugt, Marjolein

    2013-01-01

    In recent years, researchers have underlined the need for more studies of early psychosocial interventions for patients with mild cognitive impairment (MCI) and early dementia (Moniz-Cook, Vernooij-Dassen, Woods, & Orrell, 2011 ). In the last 10 years, MCI has become more 'psychosocial' and a starting point for professionals to help patients and their nearest ones to deal with their handicaps, to cope with a future that is insecure and gloomy, and to get prepared for the possibility of further decline and dependency. It is timely that Aging & Mental Health is devoting this paper, a special section in this issue with contributions dealing with psychological and social aspects of MCI. PMID:23402425

  2. A conceptual framework for evaluating impairments in myasthenia gravis.

    Directory of Open Access Journals (Sweden)

    Carolina Barnett

    Full Text Available BACKGROUND: Myasthenia gravis is characterized by weakness and fatigability of different muscle groups, including ocular, bulbar and the limbs. Therefore, a measure of disease severity at the impairment level in myasthenia needs to reflect all the relevant impairments, as well as their variations with activity and fatigue. We conducted a qualitative study of patients with myasthenia, to explore their experiences and related impairments, aimed at developing a conceptual framework of disease severity at the impairment level in myasthenia gravis. METHODS: Twenty patients representing the spectrum of disease participated in semi-structured interviews. Interviews were recorded and the transcripts were analyzed by content analysis using an inductive approach with line-by-line open coding. Themes were generated from these codes. RESULTS: Two main themes were identified: the severity of the impairments and fatigability (i.e., triggering or worsening of an impairment with activity. The impairments were further classified within body regions (ocular, bulbar and axial/limbs. Fatigability was described as a phenomenon affecting the whole body but also affecting specific impairments, and was associated with fluctuation of the symptoms. Patients were concerned that clinical examination at a single point in time might not reflect their true clinical state due to fatigability and fluctuations in severity. CONCLUSIONS: This conceptual framework reflects the relevance of both severity and fatigability in understanding impairment-based disease severity in myasthenia. This framework could inform the development of impairment measures in myasthenia gravis.

  3. Does Stroke Impair Learning in Children?

    Directory of Open Access Journals (Sweden)

    Sonia das Dores Rodrigues

    2011-01-01

    Full Text Available Objective. To assess cognitive development and learning in children who have had strokes. Method. Twenty-nine stroke patients and 18 children with no brain lesions and no learning impairments were evaluated. For the cognitive assessment, Piaget's clinical method was used. Writing, arithmetic, and reading abilities were assessed by the school performance test. Results. The mean age at evaluation was 9.6 years. Among the 29 children, 20 had early lesions (mean of 2.4 years old. The stroke was ischemic in 18 subjects; there were 7 cases of recurrence. Six children could not answer the tests. A high index of cognitive delay and low performance in writing, arithmetic, and reading were verified. Comparison with the control group revealed that the children who have had strokes had significantly lower performances. Conclusion. In this sample, strokes impaired cognitive development and learning. It is important that children have access to educational support and cognitive rehabilitation after injury. These approaches may minimise the effects of strokes on learning in children.

  4. Memory Impairment following Acute Tricyclic Antidepressants Overdose

    Directory of Open Access Journals (Sweden)

    Nastaran Eizadi-Mood

    2015-01-01

    Full Text Available Background. Psychiatric consultation is necessary for all patients with intentional poisoning and its reliability depends on the proper function of patients’ memory performance. This study aimed to determine the possible memory impairment following acute TCAs’ poisoning. Materials and Methods. In this cross-sectional study, patients with acute TCAs poisoning were allocated to two groups of severe poisoning (with coma, seizures, cardiac arrhythmias, hypotension, and a wide QRS complex and mild-to-moderate poisoning according to their clinical presentation at the time of hospital admission. All patients underwent memory performance test both immediately and 24 hours after their initial consciousness after admission, using Wechsler Memory Scale (WMS-IV. Results. During the study period, 67 TCA-poisoned patients (aged, 20–64 years were evaluated, of which 67.2% were female. The mean memory scores of patients immediately and 24 hours after the initial consciousness were 31.43±9.02 and 50.62±9.12, respectively (P<0.001. Twenty-four hours after the initial consciousness, memory score was statistically correlated with the amount of ingested drug and the intoxication severity. Conclusion. Following the recovery from somatic symptoms of acute TCA poisoning, patients may still suffer from memory impairment and it seems that this time is not suitable for performing a reliable psychiatric consultation.

  5. Enhancing Wheelchair Manoeuvrability for Severe Impairment Users

    Directory of Open Access Journals (Sweden)

    Razali Tomari

    2013-02-01

    Full Text Available A significant number of individuals with severe motor impairments are unable to control their wheelchair using a standard joystick. Even when they can facilitate the control input, navigation in a confined space or crowded environments is still a great challenge. Here we propose a wheelchair framework that enables the user to issue the command via a multi‐input hands free interface (HFI, which subsequently assists him/her to overcome difficult circumstances using a multimodal control strategy. Initially the HFI inputs are analysed to infer the desired control mode and the user command. Then environmental information is perceived using a combination of laser and Kinect sensors for determining all possible obstacle locations and outputting a safety map around the wheelchair’s vicinity. Eventually, the user’s command is validated with the safety map to moderate the final motion, which is collision free and the best for the user’s preference. The proposed method can reduce the burden of severe impairment users when controlling wheelchairs by continuously monitoring the surroundings and can make them move easily according to the users’ intention.

  6. Impaired coronary microvascular function in diabetics

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, Go [Kobe Rosai Hospital (Japan)

    2000-06-01

    Global and regional myocardial uptake was determined with technetium-99m tetrofosmin and a 4 hour exercise (370 MBq iv) and rest (740 MBq iv) protocol, in 24 patients with non-insulin dependent diabetes mellitus and in 22 control subjects. The purpose of this study was to evaluate impaired coronary microvascular function in diabetics by measurement of % uptake increase in myocardial counts. The parameter of % uptake increase ({delta}MTU) was calculated as the ratio of exercise counts to rest myocardial counts with correction of myocardial uptake for dose administered and physical decay between the exercise study and the rest study. Global {delta}MTU was significantly lower in the diabetics than in control subjects (14.4{+-}5.4% vs. 21.7{+-}8.5%, p<0.01). Regional {delta}MTU in each of 4 left ventricular regions (anterior, septal, inferior, posterolateral) was significantly lower in the diabetic group than in the control group (p<0.01) respectively, but there were no significant differences between {delta}MTU in the 4 left ventricular regions in the same group. {delta}MTU was useful as a non-invasive means of evaluating impaired coronary microvascular function in diabetics. (author)

  7. Acute stress selectively impairs learning to act.

    Science.gov (United States)

    de Berker, Archy O; Tirole, Margot; Rutledge, Robb B; Cross, Gemma F; Dolan, Raymond J; Bestmann, Sven

    2016-01-01

    Stress interferes with instrumental learning. However, choice is also influenced by non-instrumental factors, most strikingly by biases arising from Pavlovian associations that facilitate action in pursuit of rewards and inaction in the face of punishment. Whether stress impacts on instrumental learning via these Pavlovian associations is unknown. Here, in a task where valence (reward or punishment) and action (go or no-go) were orthogonalised, we asked whether the impact of stress on learning was action or valence specific. We exposed 60 human participants either to stress (socially-evaluated cold pressor test) or a control condition (room temperature water). We contrasted two hypotheses: that stress would lead to a non-selective increase in the expression of Pavlovian biases; or that stress, as an aversive state, might specifically impact action production due to the Pavlovian linkage between inaction and aversive states. We found support for the second of these hypotheses. Stress specifically impaired learning to produce an action, irrespective of the valence of the outcome, an effect consistent with a Pavlovian linkage between punishment and inaction. This deficit in action-learning was also reflected in pupillary responses; stressed individuals showed attenuated pupillary responses to action, hinting at a noradrenergic contribution to impaired action-learning under stress. PMID:27436299

  8. Cognitive impairment in human chronic Chagas' disease

    Directory of Open Access Journals (Sweden)

    C.A. Mangone

    1994-06-01

    Full Text Available We proposed to investigate subclinical cognitive impairment secondary to chronic Chagas' disease (CCD. No similar study was previously done. The neuropsychological performance of 45 chronic Chagasic patients and 26 matched controls (age, education place and years of residency in endemic area was compared using the Mini Mental State Exam (MMSE, Weschler Memory Scale (WMS and the Weschler Adult Intelligent Scale (WAIS. Non-parametric tests and Chi2 were used to compare group means and multivariate statistics in two way frequency tables for measures of independence and association of categorical variables with the disease. Results: Chagasic patients showed lower MMSE scores (p<004, poor orientation (p<.004, and attention (p<.007. Lower WMS MQ were associated with CCD (Chi2 5.9; p<.01; Fisher test p<.02. Lower WAIS IQ were associated with CCD (Chi2 6.3, p<.01; Fisher test p<.01 being the digit symbol (p<.03, picture completion (p<.03, picture arrangement (p<.01 and object assembly (p<.03 subtests the most affected. The impairment in non-verbal reasoning, speed of information processing, problem solving, learning and sequencing observed in chronic Chagas disease patients resembles the cognitive dysfunction associated with white matter disease.

  9. Novel genetic causes for cerebral visual impairment.

    Science.gov (United States)

    Bosch, Daniëlle Gm; Boonstra, F Nienke; de Leeuw, Nicole; Pfundt, Rolph; Nillesen, Willy M; de Ligt, Joep; Gilissen, Christian; Jhangiani, Shalini; Lupski, James R; Cremers, Frans Pm; de Vries, Bert Ba

    2016-05-01

    Cerebral visual impairment (CVI) is a major cause of low vision in children due to impairment in projection and/or interpretation of the visual input in the brain. Although acquired causes for CVI are well known, genetic causes underlying CVI are largely unidentified. DNAs of 25 patients with CVI and intellectual disability, but without acquired (eg, perinatal) damage, were investigated by whole-exome sequencing. The data were analyzed for de novo, autosomal-recessive, and X-linked variants, and subsequently classified into known, candidate, or unlikely to be associated with CVI. This classification was based on the Online Mendelian Inheritance in Man database, literature reports, variant characteristics, and functional relevance of the gene. After classification, variants in four genes known to be associated with CVI (AHDC1, NGLY1, NR2F1, PGAP1) in 5 patients (20%) were identified, establishing a conclusive genetic diagnosis for CVI. In addition, in 11 patients (44%) with CVI, variants in one or more candidate genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30). Our findings show that diverse genetic causes underlie CVI, some of which will provide insight into the biology underlying this disease process. PMID:26350515

  10. Probabilistic Sequence Learning in Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Dezso eNemeth

    2013-07-01

    Full Text Available Mild Cognitive Impairment (MCI causes slight but noticeable disruption in cognitive systems, primarily executive and memory functions. However, it is not clear if the development of sequence learning is affected by an impaired cognitive system and, if so, how. The goal of our study was to investigate the development of probabilistic sequence learning, from the initial acquisition to consolidation, in MCI and healthy elderly control groups. We used the Alternating Serial Reaction Time task (ASRT to measure probabilistic sequence learning. Individuals with MCI showed weaker learning performance than the healthy elderly group. However, using the reaction times only from the second half of each learning block – after the reactivation phase - we found intact learning in MCI. Based on the assumption that the first part of each learning block is related to reactivation/recall processes, we suggest that these processes are affected in MCI. The 24-hour offline period showed no effect on sequence-specific learning in either group but did on general skill learning: the healthy elderly group showed offline improvement in general reaction times while individuals with MCI did not. Our findings deepen our understanding regarding the underlying mechanisms and time course of sequence acquisition and consolidation.

  11. Cognitive impairments and depression: a critical review.

    Science.gov (United States)

    Roca, Miquel; Vives, Margalida; López-Navarro, Emilio; García-Campayo, Javier; Gili, Margalida

    2015-09-01

    Cognitive impairments are core symptoms of depressive disorders. We assess the systematic reviews and meta-analysis studies published over the last 10 years (2004-2014) that address cognitive performance of depressed patients and taking into account age; clinical and demographic features; symptom severity; number of previous episodes; clinical remission; depressive subtypes and pharmacological treatment. Twelve (12) papers were included after search in international databases. In first episode depression the cognitive domains affected were psychomotor speed, attention, visual learning and memory as well as executive functions. Depressive patients in remission phase improved their performance in attention tasks although they did not achieve similar performance levels as healthy controls. Melancholic patients seem to have a different pattern of cognitive impairment compared with non-melancholic depressive patients. Patients treated with the current antidepressants perform worse in inhibition tasks, verbal fluency, and working memory scores as well as on composite scores of visual and verbal working memory. Future research should study longitudinal outcome and clinical relevance of cognitive symptoms, determine their underlying etiopathogenesis and how they impact on clinical functioning. Specifically, it would be important to analyze the ability of the new antidepressant drugs to improve affective symptoms as well as cognitive dysfunctions. PMID:26320897

  12. Hidden Language Impairments in Children: Parallels between Poor Reading Comprehension and Specific Language Impairment?

    Science.gov (United States)

    Nation, Kate; Clarke, Paula; Marshall, Catherine M.; Durand, Marianne

    2004-01-01

    This study investigates the oral language skills of 8-year-old children with impaired reading comprehension. Despite fluent and accurate reading and normal nonverbal ability, these children are poor at understanding what they have read. Tasks tapping 3 domains of oral language, namely phonology, semantics, and morphosyntax, were administered,…

  13. Concurrent impairments in sleep and memory in amnestic mild cognitive impairment.

    Science.gov (United States)

    Westerberg, Carmen E; Mander, Bryce A; Florczak, Susan M; Weintraub, Sandra; Mesulam, M-Marsel; Zee, Phyllis C; Paller, Ken A

    2012-05-01

    Whereas patients with Alzheimer's disease (AD) experience difficulties forming and retrieving memories, their memory impairments may also partially reflect an unrecognized dysfunction in sleep-dependent consolidation that normally stabilizes declarative memory storage across cortical areas. Patients with amnestic mild cognitive impairment (aMCI) exhibit circumscribed declarative memory deficits, and many eventually progress to an AD diagnosis. Whether sleep is disrupted in aMCI and whether sleep disruptions contribute to memory impairment is unknown. We measured sleep physiology and memory for two nights and found that aMCI patients had fewer stage-2 spindles than age-matched healthy adults. Furthermore, aMCI patients spent less time in slow-wave sleep and showed lower delta and theta power during sleep compared to controls. Slow-wave and theta activity during sleep appear to reflect important aspects of memory processing, as evening-to-morning change in declarative memory correlated with delta and theta power during intervening sleep in both groups. These results suggest that sleep changes in aMCI patients contribute to memory impairments by interfering with sleep-dependent memory consolidation. PMID:22300710

  14. Sleep impairment and prognosis of acute myocardial infarction

    DEFF Research Database (Denmark)

    Clark, Alice; Lange, Theis; Hallqvist, Johan;

    2014-01-01

    STUDY OBJECTIVES: Impaired sleep is an established risk factor for the development of cardiovascular disease, whereas less is known about how impaired sleep affects cardiovascular prognosis. The aim of this study is to determine how different aspects of impaired sleep affect the risk of case...... fatality and subsequent cardiovascular events following first-time acute myocardial infarction (AMI). DESIGN: Prospective cohort study. SETTING: The Stockholm Heart Epidemiology Program, Sweden. PARTICIPANTS: There were 2,246 first-time AMI cases. MEASUREMENTS AND RESULTS: SLEEP IMPAIRMENT WAS ASSESSED BY...... THE KAROLINA SLEEP QUESTIONNAIRE, WHICH COVERS VARIOUS INDICES OF IMPAIRED SLEEP: disturbed sleep, impaired awakening, daytime sleepiness, and nightmares. Case fatality, defined as death within 28 days of initial AMI, and new cardiovascular events within up to 10 y of follow-up were identified through...

  15. Depreciation and impairment. A tradeoff in a stewardship setting

    OpenAIRE

    Scholze, Andreas; Wielenberg, Stefan

    2007-01-01

    This paper examines the relationship between depreciation and future impairment losses. This relationship exists, since impairment losses can only be recognized if the carrying amount of an asset exceeds a certain recoverable amount that can be defined in different ways. Sufficiently large depreciation charges in the beginning of the asset's useful life make it very unlikely that an impairment acutally occurs in future periods. In the context of a multi-period agency model with ex ante long-t...

  16. Associations of HLA alleles with specific language impairment

    OpenAIRE

    Nudel, Ron; Simpson, Nuala H; Baird, Gillian; O’Hare, Anne; Conti-Ramsden, Gina; Bolton, Patrick F.; Hennessy, Elizabeth R; Monaco, Anthony P; Knight, Julian C.; Winney, Bruce; Fisher, Simon E.; Newbury, Dianne F

    2014-01-01

    Background Human leukocyte antigen (HLA) loci have been implicated in several neurodevelopmental disorders in which language is affected. However, to date, no studies have investigated the possible involvement of HLA loci in specific language impairment (SLI), a disorder that is defined primarily upon unexpected language impairment. We report association analyses of single-nucleotide polymorphisms (SNPs) and HLA types in a cohort of individuals affected by language impairment. Methods We perf...

  17. Awareness of Academic Writing among Hearing Impaired Students

    OpenAIRE

    Hosoya, Miyoko

    2006-01-01

    This paper addresses the teaching of academic writing to hearing impaired (Deaf) students. The study assesses awareness of academic writing by students and covers 135 students at the Division for the Hearing Impaired at Tsukuba College of Technology. The study shows that; 1. the interest and motivation of hearing impaired students in academic writing is very high 2. students are aware of their inability, but cannot recognize where they experience problems.

  18. Guideline Development for the Evaluation of Visual Impairment in Korea

    OpenAIRE

    Chin, Hee Seung; Park, Song Hee; Park, In Ki; Kwon, Ji Won; Lee, Soo Jeong

    2009-01-01

    This guideline is developed to provide criteria for evaluating permanent impairment of the visual system as it affects an individual's ability to perform activities of daily living. This new assessment system is based on the 5th and 6th edition of American Medical Association and McBride impairment assessment system but revised on the consideration of Korean culture and simple application. This evaluation of impairment is based on an assessment of visual acuity and visual field. Especially it...

  19. Making Gestural Interaction Accessible to Visually Impaired People

    OpenAIRE

    Brock, Anke; Truillet, Philippe; Oriola, Bernard; Jouffrais, Christophe

    2014-01-01

    As touch screens become widely spread, making them more accessible to visually impaired people is an important task. Touch displays possess a poor accessibility for visually impaired people. One possibility to make them more accessible without sight is through gestural interaction. Yet, there are still few studies on using gestural interaction for visually impaired people. In this paper we present a comprehensive summary of existing projects investigating accessible gestural interaction. We a...

  20. Architects and visually impaired people: analysing two ways of talking

    OpenAIRE

    Peter-Willem Vermeersch; Megan Strickfaden; Jasmien Herssens; Ann Heylighen

    2009-01-01

    While architects think and work in a visual way, people who are visually impaired may pay more attention to other senses and, as a result, are able to appreciate other spatial qualities. Because of this particular ability, our research seeks to explore how to enhance communication between architects and visually impaired people. It is imaginable that there is significant disparity between how architects and visually impaired people talk; even so, this paper seeks to discover points of connect...

  1. Congenital Blindness and Visual Impairment Cause Infection or Non Infection

    OpenAIRE

    Mirjana A. Janicijevic-Petrovic; Tatjana S. Sarenac-Vulovic; Katarina M. Janicijevic; Dragan I. Vujic; Dejan D. Vulovic

    2013-01-01

    Conflict of interest: none declared. Introduction Authors are from reference documentation to archive at Organization of Federation of blind and visually impaired in central Serbia (Kragujevac), by retrograde analysis, of 2007-2012, comprehend two groups by etiology–clinical characteristics of congenital blindness and visually impaired, caused infection or non infection example. Aim to analyze relationship between infectious and non infectious of congenital blindness and visually impaired in ...

  2. Voice and GPS Based Navigation System For Visually Impaired

    OpenAIRE

    Harsha Gawari; Prof. Meeta Bakuli

    2014-01-01

    The paper represents the architecture and implementation of a system that will help in the navigation of the visually impaired people. The system that we have designed uses GPS and voice recognition along with obstacle avoidance for the purpose of guiding visually impaired. The visually impaired person issues the command and receives the direction response using audio signals. The latitude and longitude values are received continuously from the GPS receiver. The directions are given to the us...

  3. Tactile outline graphics for people who are visually impaired

    OpenAIRE

    Petrič, Ajda

    2013-01-01

    Tactile outline graphics are an important means for the blind and visually impaired. The grahics help to complete the images and contribute to understand special notions which are directly unavailable. Spreading the material which is primarily designed for the blind and visually impaired, contribute to indirect public awarness-rising how to communicate correctly with such people. More knowledge enables to the blind and visually impaired to the social integration, awarness-rising of the correc...

  4. Type 2 diabetes and cognitive impairment: linking mechanisms

    OpenAIRE

    Luchsinger, José A.

    2012-01-01

    This manuscript provides a brief review of current concepts in the mechanisms potentially linking type-2-diabetes (T2D) with cognitive impairment. Existing epidemiologic studies, imaging studies, autopsy studies and clinical trials provide insights into the mechanisms linking T2D and cognitive impairment. There seems to be little dispute that T2D can cause cerebrovascular disease and thus cause vascular cognitive impairment (VCI). Whether T2D can cause late onset Alzheimer’s disease (LOAD) re...

  5. Prevalence of Cognitive Impairment in Community-Dwelling Older Adults

    OpenAIRE

    Rashedi, Vahid; Rezaei, Mohammad; Gharib, Masoud

    2014-01-01

    Introduction Mild cognitive impairment can be considered as an intermediate clinical state between normal cognitive aging and mild dementia. Elderly people with this impairment represent an at-risk group for the development of dementia. The aim of this study was to investigate the prevalence of cognitive impairment in community-dwelling older adults by Mini-Mental State Examination (MMSE) and its relationship with socio-demographic variables. Methods In this analytical-descriptive study, 212 ...

  6. Cognitive Impairment in Affective Psychoses: A Meta-analysis

    OpenAIRE

    Bora, Emre; Yücel, Murat; Pantelis, Christos

    2009-01-01

    It has recently been suggested that cognitive impairment should be included in the diagnostic criteria of schizophrenia. One of the main arguments in support of this suggestion has been the hope that cognitive impairment can help distinguish schizophrenia from bipolar disorder (BD). However, recent evidence shows that cognitive deficits occur in BD and persist beyond euthymia. Further, mood disorders with psychotic features might be expected to manifest greater cognitive impairment, which fur...

  7. A comparison of oral hygiene status and dental caries experience among institutionalized visually impaired and hearing impaired children of age between 7 and 17 years in central India

    OpenAIRE

    Venugopal K Reddy; Kshitij Chaurasia; Ajay Bhambal; Ninad Moon; Eshwar K Reddy

    2013-01-01

    Aim: The aim of this study is to compare the oral hygiene status and dental caries experience among institutionalized visually impaired and hearing impaired children of age between 7 and 17 years in Bhopal city of Madhya Pradesh located in Central India. Materials and Methods: A total of 95 hearing impaired and 48 visually impaired children of age between 7 and 17 years were recruited from special care institutions (one institution of hearing impaired and two institutions of visually impaired...

  8. Performance Visualization for Hearing-Impaired Students

    Directory of Open Access Journals (Sweden)

    Rumi Hiraga

    2005-10-01

    Full Text Available We have been teaching computer music to hearing impaired students of Tsukuba College of Technology for six years. Although students have hearing difficulties, almost all of them show an interest in music. Thus, this has been a challenging class to turn their weakness into enjoyment. We thought that performance visualization is a good method for them to keep their interest in music and try cooperative performances with others. In this paper, we describe our computer music class and the result of our preliminary experiment on the effectiveness of visual assistance. Though it was not a complete experiment with a sufficient number of subjects, the result showed that the show-ahead and selected-note-only types of performance visualization were necessary according to the purpose of the visual aid.

  9. Automatic hypermnesia and impaired recollection in schizophrenia.

    Science.gov (United States)

    Linscott, R J; Knight, R G

    2001-10-01

    Evidence from studies of nonmnemonic automatic cognitive processes provides reason to expect that schizophrenia is associated with exaggerated automatic memory (implicit memory), or automatic hypermnesia. Participants with schizophrenia (n = 22) and control participants (n = 26) were compared on word stem completion (WSC) and list discrimination (LD) tasks administered using the process dissociation procedure. Unadjusted, extended measurement model and dual-process signal-detection methods were used to estimate recollection and automatic memory indices. Schizophrenia was associated with automatic hypermnesia on the WSC task and impaired recollection on both tasks. Thought disorder was associated with even greater automatic hypermnesia. The absence of automatic hypermnesia on the LD task was interpreted with reference to the neuropsychological bases of context and content memory. PMID:11761047

  10. Cognitive impairment in heart failure patients

    Institute of Scientific and Technical Information of China (English)

    Laura Leto; Mauro Feola

    2014-01-01

    Cognitive damage in heart failure (HF) involves different domains thus interfering with the ability for single patient to self-care and to cope with treatment regimens, modifying symptoms and health behaviours. Many cerebral and functional changes were detected in brain imaging, involving areas of both grey and white matter deputed to cognition. Although various instruments are available to explore cognition, no consensus was obtained on better tools to be used in HF population. Reduction in cerebral blood flow, decreased cardiac output, altera-tions of cerebrovascular reactivity and modification of blood pressure levels are the main features involved in the etiopathogenetic mecha-nisms of cognitive deficit. Several cardiac variables, laboratory parameters, demographic and clinical elements were studied for their possible relation with cognition and should be properly evaluated to define patients at increased risk of impairment. The present review gathers avail-able data pointing out assured information and discussing possible areas of research development.

  11. Modeling Speech Intelligibility in Hearing Impaired Listeners

    DEFF Research Database (Denmark)

    Scheidiger, Christoph; Jørgensen, Søren; Dau, Torsten

    2014-01-01

    threshold (SRT) of HI people in stationary noise compared to NH. However, this approach can, to some extent, account for the reduced ability of HI people to listen in the dips as measured by a reduced masking release (MR), where MR is dened as the SRT benefit listeners obtain in uctuating noise compared to...... speech, e.g. phase jitter or spectral subtraction. Recent studies predict SI for normal-hearing (NH) listeners based on a signal-to-noise ratio measure in the envelope domain (SNRenv), in the framework of the speech-based envelope power spectrum model (sEPSM, [20, 21]). These models have shown good...... agreement with measured data under a broad range of conditions, including stationary and modulated interferers, reverberation, and spectral subtraction. Despite the advances in modeling intelligibility in NH listeners, a broadly applicable model that can predict SI in hearing-impaired (HI) listeners is not...

  12. Functional Hubs in Mild Cognitive Impairment

    Science.gov (United States)

    Navas, Adrián; Papo, David; Boccaletti, Stefano; Del-Pozo, F.; Bajo, Ricardo; Maestú, Fernando; Martínez, J. H.; Gil, Pablo; Sendiña-Nadal, Irene; Buldú, Javier M.

    We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.

  13. [Cognitive impairment of alcohol-dependent subjects].

    Science.gov (United States)

    Bernardin, Florent; Maheut-Bosser, Anne; Paille, François

    2014-04-01

    Chronic excessive alcohol consumption induces multiple brain damages. Secondary cognitive disorders include executive functions, episodic memory and visuospatial capacities. The severity of these alcohol induced disorders may vary between sub-clinical manifestations (that may, nevertheless, interfere with medical management) and more important ones like Korsakoff syndrome or dementia. The latter are usually irreversible but many of these manifestations are potentially reversible with persistent abstinence. It therefore appears of particular importance to clearly define neuropsychological management in order to identify and evaluate the type and severity of alcohol-related cognitive disorders. The patients may then be offered rehabilitation for these cognitive impairments. This is the first step of a complete addiction program based especially on cognitive behavioral therapies. PMID:24855773

  14. SUCCES AT SCHOOL IN VISUALLY IMPAIRED CHILDREN

    Directory of Open Access Journals (Sweden)

    Stanika DIKIC

    1998-04-01

    Full Text Available The research included 200 visually impaired children of primary school during the period from 1992 to 1996. By means of adequate instruments we have tested the relation between the success at school of partially seeing children and hyperkinetic behavior, active and passive vocabulary richness, visuo-motoric coordination and the maturity of handwriting. Besides the already known factors (intellectual level, specific learning disturbances, emotional and neurotic disturbances, cultural deprivation, the success in class depends very much on the intensity of hyperkinetic behavior as well as its features: unstable attention, impulsiveness and hyperactivity. Visual-motor coordination eye-hand and the maturity of handwriting have a strong influence on their success at school.

  15. Impaired regulatory B cells in myasthenia gravis.

    Science.gov (United States)

    Sheng, Jian Rong; Rezania, Kourosh; Soliven, Betty

    2016-08-15

    Regulatory B cells (Bregs) attenuate the severity of experimental autoimmune myasthenia gravis (EAMG) in an interleukin-10 (IL-10)-dependent manner. The goal of this study was to investigate the role of human Bregs in MG focusing on CD19(+)CD1d(hi) CD5(+) and CD19(+)CD24(hi)CD38(hi) subsets. We found that MG patients exhibited a decrease in the frequency of both Breg subsets and IL-10 producing B cells within each subset, which correlated with disease severity. In addition, there was impaired suppression of Th1 polarization in MG. These findings, taken together with EAMG data, indicate that Bregs play an important role in regulating the severity of MG. PMID:27397074

  16. Impaired postural stability after laparoscopic surgery

    DEFF Research Database (Denmark)

    Eskildsen, K Z; Staehr-Rye, A K; Rasmussen, L S; Rosenberg, J; Claudius, C; Kjaer, B H; Clausen, H V; Gätke, M R

    2015-01-01

    BACKGROUND: Early postoperative mobilisation may reduce patient morbidity and improve hospital efficiency by accelerated discharge. The aim of this study was to measure postural stability early after laparoscopic surgery in order to assess how early it is safe to mobilise and discharge patients....... METHODS: We included 25 women undergoing outpatient gynaecological laparoscopic surgery in the study. Patients received standardised anaesthesia with propofol, remifentanil and rocuronium. Postural stability was assessed preoperatively, at 30 min after tracheal extubation, and at discharge from the post...... postoperatively. No significant changes were found for sway velocity. We found no significant changes in mean sway, sway area or sway velocity at discharge from the post-anaesthesia care unit approximately 2 h after surgery. CONCLUSION: Postural stability was significantly impaired 30 min after outpatient...

  17. Spatial memory impairments in amnestic mild cognitive impairment in a virtual radial arm maze

    Directory of Open Access Journals (Sweden)

    Lee JY

    2014-04-01

    Full Text Available Jun-Young Lee,1,2 Sooyeon Kho,1,2 Hye Bin Yoo,1,2 Soowon Park,1,2 Jung-Seok Choi,1,2 Jun Soo Kwon,3 Kyung Ryeol Cha,4 Hee-Yeon Jung1,21Department of Psychiatry, Seoul National University, 2Seoul Metropolitan Government – Seoul National University Boramae Medical Center, 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; 4Department of Psychiatry, Osan Mental Hospital, Gyeonggi, South KoreaObjective: This study aims to apply the virtual radial arm maze (VRAM task to find spatial working memory and reference memory impairments in patients of amnestic mild cognitive impairment (aMCI and Alzheimer's disease (AD. Spatial memory functions between aMCI converters and nonconverters are also compared using VRAM results.Methods: We assessed the spatial memory in 20 normal controls, 20 aMCI, and 20 mild AD subjects using VRAM. The Mini-Mental State Examination, Clinical Dementia Rating scale, and other neuropsychological tests were given to the subjects in conjunction with the VRAM test. Scores in working memory errors and reference memory errors were compared among the three groups using repeated measures analysis of variance. In addition, aMCI patients were followed-up after 5 years and surveyed for AD conversion rate.Results: In AD patients, both spatial working and reference memory were impaired. However, in aMCI subjects, only spatial reference memory was impaired. Significant spatial reference memory impairment was found in the aMCI converter group when compared to the nonconverter group.Conclusion: Spatial working memory is less impaired in aMCI while reference memory is similarly damaged in AD. In aMCI patients, more severe spatial reference memory deficit is a neuropsychological marker for AD conversion. VRAM may be well utilized in humans to assess spatial memory in normal aging, in aMCI, and in AD.Keywords: spatial behavior, Alzheimer's disease, user computer interface, cognition

  18. Impaired lysosomal cobalamin transport in Alzheimer's disease.

    Science.gov (United States)

    Zhao, Hua; Li, Hongyun; Ruberu, Kalani; Garner, Brett

    2015-01-01

    Cobalamin (vitamin B12) is required for erythrocyte formation and DNA synthesis and it plays a crucial role in maintaining neurological function. As a coenzyme for methionine synthase and methylmalonyl-CoA mutase, cobalamin utilization depends on its efficient transit through the intracellular lysosomal compartment and subsequent delivery to the cytosol and mitochondria. Lysosomal function deteriorates in Alzheimer's disease (AD). Lysosomal acidification is defective in AD and lysosomal proteolysis is disrupted by AD-related presenilin 1 mutation. In this study, we propose that AD related lysosomal dysfunction may impair lysosomal cobalamin transport. The experiments use in vitro and in vivo models of AD to define how lysosomal dysfunction directly affects cobalamin utilization. SH-SY5Y-AβPP mutant cells were treated with a proteasome inhibitor to induce lysosomal amyloid-β accumulation. We metabolically labeled these cells with [57Co] cobalamin and isolated purified lysosomes, mitochondria, and cytosol fractions. The results indicated that proteasome inhibition was associated with lysosomal amyloid-β accumulation and a doubling of lysosomal [57Co] cobalamin levels. We also used AβPPxPS1 transgenic AD mice that were intraperitoneally injected with [57Co] cobalamin. The amount of [57Co] cobalamin in the major organs of these mice was measured and the subcellular [57Co] cobalamin distribution in the brain was assessed. The results demonstrated that lysosomal [57Co] cobalamin level was significantly increased by 56% in the AβPPxPS1 AD mouse brains as compared to wild type control mice. Together these data provide evidence that lysosomal cobalamin may be impaired in AD in association with amyloid-β accumulation. PMID:25125476

  19. Visually Impaired Children's Acceptances on Assistive Courseware

    Directory of Open Access Journals (Sweden)

    Nurulnadwan Aziz

    2011-01-01

    Full Text Available Problem statement: The government of Malaysia is considering serious efforts in promoting the usage of computers among disabled people. Currently, the availability of computer applications especially related to creative contents for disabled people in Malaysia is infancy and very expensive. Research and expertise in the area of Assistive Technology (AT in Malaysia is still uncommon and not extensively utilized. Therefore research involving special communities such as disabled people on the usage of electronic applications should be focused because records show that their population populations are increasing. Hence, this research will be tailored for Visually-Impaired (VI learners. In Malaysia, visual impairment is one of the highest registered disabilities. Approach: This study presents an ongoing project that determines whether the VI children can accept the Assistive Courseware (AC as one of the effective tools in their learning process. Specification identification, AC development and testing and evaluation are three activities involved in this study. In addition, data have been collected through qualitative approaches. Results: The results highlight four important elements for incorporated in an AC for VI children. Through the testing and evaluation, it was found that the VI children accept the AC due to interesting usage of audio, graphic, text and easy navigation method. Conclusion: In a nutshell, the positive responses prove that the AC not only exposes the VI children to the world of technology but also educates them in terms of interpersonal skills, intrapersonal skills and motivation. The recommended future work is to produce a much comprehensive AC which focuses on interactivity, various multimedia elements, multiple intelligence elements and multiple stages of exercise in granting value-added AC not only for VI children in Malaysia but also to other world VI communities in the world.

  20. Early intervention programme for hearing impaired children.

    Science.gov (United States)

    Narayanswamy, S

    1992-01-01

    The School for Young Deaf Children was founded in 1969 when the All India Institute of Speech and Hearing at Mysore and the Christian Medical College Hospital at Vellore started diagnosing hearing impairment in children and prescribing hearing aids. These schools admitted children when they were 5 years old. Bala Vidyalaya was funded as an experimental school to satisfy the needs of younger children. A multi sensory approach based on the Montessori method of teaching with special emphasis on language acquisition was adopted. The School that began with 5 children and 2 teachers had 120 children and 15 teachers in 1992: 50 children were under 3 years old and the rest were between 3 and 6 years. Early auditory management and training is the foundation of the child's linguistic achievement which help the child use the innate ability to develop sophisticated listening skills such as listening to one signal in the presence of competing sounds. Simple games captivate the infants. At the age of 2 1/2 years ideovisual reading is introduced to the child: written sentences are presented to the child about an activity that the child had just experienced. Even before 2 years of age he or she starts scribbling. School lessons are used as tools for writing. The school takes efforts to win the confidence of the parents. So far 97 children have joined the mainstream of education after an initial training the school. Of these, 6 are settled in jobs, 5 are in college or in postgraduate studies, 11 are studying at the university, 8 are in the higher secondary school (classes XI or XII)m 28 are studying in high school (class VI to class X), while the remaining 39 are in primary schools. It has been demonstrated that early educational intervention and involvement of the family into the educational program are very important for the successful integration of hearing-impaired children into the main stream. PMID:12286296

  1. Neuromuscular impairment following backpack load carriage.

    Science.gov (United States)

    Blacker, Sam D; Fallowfield, Joanne L; Bilzon, James L J; Willems, Mark E T

    2013-01-01

    Load Carriage using backpacks is an occupational task and can be a recreational pursuit. The aim of this study was to investigate the mechanisms responsible for changes in neuromuscular function of the m. quadriceps femoris following load carriage. The physiological responses of 10 male participants to voluntary and electrically stimulated isometric contractions were measured before and immediately after two hours of treadmill walking at 6.5 km•h(-1) during level walking with no load [LW], and level walking with load carriage (25 kg backpack) [LC]. Maximal voluntary contraction force decreased by 15 ± 11 % following LC (p=0.006), with no change following LW (p=0.292). Voluntary activation decreased after LW and LC (p=0.033) with no difference between conditions (p=0.405). Doublet contraction time decreased after both LW and LC (p=0.002), with no difference between conditions (p=0.232). There were no other changes in electrically invoked doublet parameters in either condition. The 20:50 Hz ratio did not change following LW (p=0.864) but decreased from 0.88 ± 0.04 to 0.84 ± 0.04 after LC (p=0.011) indicating reduced Ca2+ release from the sarcoplasmic reticulum during excitation contraction coupling. In conclusion, two hours of load carriage carrying a 25 kg back pack caused neuromuscular impairment through a decrease in voluntary activation (i.e. central drive) and fatigue or damage to the peripheral muscle, including impairment of the excitation contraction coupling process. This may reduce physical performance and increase the risk of musculoskeletal injury. PMID:24146709

  2. Non-word repetition impairment in autism and specific language impairment: Evidence for distinct underlying neuro-cognitive causes

    OpenAIRE

    David M. Williams; Payne, Heather; Marshall, Chloe

    2013-01-01

    Language-impaired individuals with autism perform poorly on tests such as non-word repetition that are sensitive clinical markers of specific language impairment (SLI). This has fuelled the theory that language impairment in autism represents co-morbid SLI. However, the underlying cause of these deficits may be different in each disorder. In a novel task, we manipulated non-word stimuli in three ways known to influence the repetition accuracy of children with SLI. Participants with SLI we...

  3. Age-related impairments on one hippocampal-dependent task predict impairments on a subsequent hippocampal-dependent task

    OpenAIRE

    Curlik, Daniel M.; Weiss, Craig; Nicholson, Daniel A.; Disterhoft, John F.

    2014-01-01

    Age-related cognitive impairments are particularly prevalent in forms of learning that require a functionally intact hippocampal formation, such as spatial learning and declarative memory. However, there is notable heterogeneity in the cognitive abilities of aged subjects. To date, few studies have determined whether age-related impairments on one learning task relate to impairments on different learning tasks that engage overlapping cognitive processes. Here, we hypothesized that aged animal...

  4. PSYCHOSOCIAL INFLUENCE OF HEARING IMPAIRMENT ON THE INTERPERSONAL BEHAVIOR OF YOUTHS WITH HEARING IMPAIRMENT IN OYO STATE, NIGERIA

    Directory of Open Access Journals (Sweden)

    Osisanya AYO

    2013-03-01

    Full Text Available Individuals with hearing impairment are confronted with a lot of problems due to the condition of their disability. This has a negative impact on their social and psychological well-being with multiplying effect on their interpersonal relationship. Therefore, this study investigated the psycho-social influence of hearing impairment on interpersonal behavior of youths with hearing loss.MethodologyThe study adopted a survey research design. A sample consisting of 211 participants with hearing loss were purposively selected from the Federal College of Education (Special Oyo, Nigeria. A questionnaire, part of Psycho-social Competence Scale (PCS, was used for data collection with reliability coefficient of 0.72.ResultsThe findings revealed that hearing impairement affects social interaction of youths with hearing impairment, hearing loss affects emotional well-being of youths with hearing impairment and youths with hearing impairment feel inferior in company of persons without hearing impairment. Based on this, it was recommended that a friendly home environment should be made and youths with hearing impairment should be advised to accept their loss and take it as a challenge that can be used to achieve a better end and the society should have right attitude and beliefs toward youths with hearing impairment.

  5. Renal impairment in a rural African antiretroviral programme

    Directory of Open Access Journals (Sweden)

    Lessells Richard J

    2009-08-01

    Full Text Available Abstract Background There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofovir, such information is important for the planning of antiretroviral programmes Methods (i Retrospective review of the prevalence and risk factors for impaired renal function in 2189 individuals initiating antiretroviral treatment in a rural African setting between 2004 and 2007 (ii A prospective study of 149 consecutive patients initiating antiretrovirals to assess the utility of urine analysis for the detection of impaired renal function. Severe renal and moderately impaired renal function were defined as an estimated GFR of ≤ 30 mls/min/1.73 m2 and 30–60 mls/min/1.73 m2 respectively. Logistic regression was used to determine odds ratio (OR of significantly impaired renal function (combining severe and moderate impairment. Co-variates for analysis were age, sex and CD4 count at initiation. Results (i There was a low prevalence of severe renal impairment (29/2189, 1.3% 95% C.I. 0.8–1.8 whereas moderate renal impairment was more frequent (287/2189, 13.1% 95% C.I. 11.6–14.5 with many patients having advanced immunosuppression at treatment initiation (median CD4 120 cells/μl. In multivariable logistic regression age over 40 (aOR 4.65, 95% C.I. 3.54–6.1, male gender (aOR 1.89, 95% C.I. 1.39–2.56 and CD4 Conclusion In this rural African setting, significant renal impairment is uncommon in patients initiating antiretrovirals. Urine analysis alone may be inadequate for identification of those with impaired renal function where resources for biochemistry are limited.

  6. Recognition of losses to impairment of assets: impairment in oil operation and production assets

    OpenAIRE

    Odilanei Morais dos Santos; Ariovaldo dos Santos; Paula Danyelle Almeida da Silva

    2011-01-01

    Losses to impairment of assets are placed in the context that assets cannot be registered above their recoverable amount, through use or sale of by the company. In the oil sector, the representativeness of exploration and production assets is relevant and meaningful. Therefore, the practice in the industry is not new and dates of the 70’s. Moreover, oil companies are obligated to publish additional information about their typical activities. Thus, the purpose is to analyze how this addition...

  7. All subtypes of mild cognitive impairment are impaired in episodic-like memory

    Czech Academy of Sciences Publication Activity Database

    Vlček, Kamil; Laczó, J.; Vajnerová, O.; Ort, Michael; Vyhnálek, M.; Hort, Jan

    Praha: The Czech Neuroscience Society, 2007. s. 78-78. [Conference of the Czech Neuroscience Society /6./. 19.11.2007-20.11.2007, Praha] R&D Projects: GA MŠk(CZ) 1M0517; GA ČR(CZ) GA309/06/1231 Institutional research plan: CEZ:AV0Z50110509 Keywords : spo2 * mild cognitive impairment * spatial navigation * Alzheimer 's disease Subject RIV: FH - Neurology

  8. Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease

    OpenAIRE

    Hayashi, Atsuko; Nomura, Hiroshi; Mochizuki, Ruriko; Ohnuma, Ayumu; Kimpara, Teiko; SUZUKI, Kyoko; Mori, Etsuro

    2015-01-01

    Background/Aims We investigated writing abilities in patients with the amnestic type of mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD). To examine the earliest changes in writing function, we used writing tests for both words and sentences with different types of Japanese characters (Hiragana, Katakana, and Kanji). Methods A total of 25 aMCI patients, 38 AD patients, and 22 healthy controls performed writing to dictation for Kana and Kanji words, copied Kanji words, and wr...

  9. Impaired neural discrimination of emotional speech prosody in children with autism spectrum disorder and language impairment.

    Science.gov (United States)

    Lindström, R; Lepistö-Paisley, T; Vanhala, R; Alén, R; Kujala, T

    2016-08-15

    Autism spectrum disorders (ASD) are characterized by deficient social and communication skills, including difficulties in perceiving speech prosody. The present study addressed processing of emotional prosodic changes (sad, scornful and commanding) in natural word stimuli in typically developed school-aged children and in children with ASD and language impairment. We found that the responses to a repetitive word were diminished in amplitude in the children with ASD, reflecting impaired speech encoding. Furthermore, the amplitude of the MMN/LDN component, reflecting cortical discrimination of sound changes, was diminished in the children with ASD for the scornful deviant. In addition, the amplitude of the P3a, reflecting involuntary orienting to attention-catching changes, was diminished in the children with ASD for the scornful deviant and tended to be smaller for the sad deviant. These results suggest that prosody processing in ASD is impaired at various levels of neural processing, including deficient pre-attentive discrimination and involuntary orientation to speech prosody. PMID:27291458

  10. Medical Impairment and Computational Reduction to a Single Whole Person Impairment (WPI) Rating Value

    Science.gov (United States)

    Artz, Jerry; Alchemy, John; Weilepp, Anne; Bongiovanni, Michael; Siddhartha, Kumar

    2014-03-01

    A medical, biophysics, engineering collaboration has produced a standardized cloud-based application for creating automated WPI ratings. The project assigns numerical values to injuries/illness in accordance with the American Medical Association Guides to the Evaluation of Permanent Impairment, Fifth Edition, AMA Press handbook, 5th edition (with 63 medical contributors and 89 medical reviewers). The AMA Guide serves as the industry standard for assigning impairment values for 32 US states and 190 other countries. Clinical medical data is collected using a menu-driven user interface which is computationally combined into a single numeric value. A medical doctor performs a biometric analysis and enters the quantitative data into a mobile device. The data is analyzed using proprietary validation algorithms, and a WPI Impairment rating is created. The findings are imbedded into a formalized medicolegal report in a matter of minutes. This particular presentation will concentrate upon the WPI rating of the spine--cervical, thoracic, and lumbar. Both common rating techniques will be presented--i.e., Diagnosis Related Estimates (DRE) and Range of Motion (ROM).

  11. Face Scanning Distinguishes Social from Communication Impairments in Autism

    Science.gov (United States)

    Falck-Ytter, Terje; Fernell, Elisabeth; Gillberg, Christopher; Von Hofsten, Claes

    2010-01-01

    How closely related are the social and communicative impairments in Autism Spectrum Disorder (ASD)? Recent findings in typically developing children suggest that both types of impairment are highly heritable but have only moderate behavioural and genetic overlap. So far, their respective roles in social perception are poorly understood. Here we…

  12. Gestural Abilities of Children with Specific Language Impairment

    Science.gov (United States)

    Wray, Charlotte; Norbury, Courtenay Frazier; Alcock, Katie

    2016-01-01

    Background: Specific language impairment (SLI) is diagnosed when language is significantly below chronological age expectations in the absence of other developmental disorders, sensory impairments or global developmental delays. It has been suggested that gesture may enhance communication in children with SLI by providing an alternative means to…

  13. Adults with Intellectual Impairment Who Stammer: A Clinical Case Study

    Science.gov (United States)

    Stansfield, Jois; Collier, Ruth; King, Ruth

    2012-01-01

    Adults with intellectual impairments have a high prevalence of stammering. Characteristic speech and associated behaviours are also different in quality and more variable between individuals than those of the typical adult population. This paper describes a speech and language therapy group with two adults with intellectual impairments and…

  14. Language impairments in sign language: breakthroughs and puzzles

    OpenAIRE

    Morgan, G.; Herman, R.; Woll, B.

    2007-01-01

    Short Report. Background: Specific Language Impairment (SLI) has previously solely been documented for children acquiring spoken languages despite informal reports of deaf children with possible sign language disorder. Aims: This research evaluates current theories of SLI in light of cases of sign language impairment. Current explanations for SLI include deficits in processing the acoustic signal, phonological short-term memory and grammatical computation. Methods:...

  15. Impairments in Learning Due to Motivational Conflict: Situation Really Matters

    Science.gov (United States)

    Brassler, Nina K.; Grund, Axel; Hilckmann, Kristina; Fries, Stefan

    2016-01-01

    Although many theories mention distractions by conflicting alternatives as a problem for self-regulation, motivational conflicts are rarely considered when explaining impairments in learning. In two studies, we investigate the assumption of motivational interference theory that students show different amounts of impairments in learning depending…

  16. AODA Training Experiences of Blindness and Visual Impairment Professionals

    Science.gov (United States)

    Davis, S. J.; Koch, D. Shane; McKee, Marissa F.; Nelipovich, Michael

    2009-01-01

    Co-existing alcohol and other drug abuse (AODA) and blindness or visually impairment may complicate the delivery of rehabilitation services. Professionals working with individuals who are blind or visually impaired need to be aware of unique issues facing those with co-existing disabilities. This study sought to examine the AODA training needs,…

  17. 20 CFR 220.145 - Impairment-related work expenses.

    Science.gov (United States)

    2010-04-01

    ... ACT DETERMINING DISABILITY Substantial Gainful Activity § 220.145 Impairment-related work expenses. (a... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Impairment-related work expenses. 220.145... work. The costs are deductible even though the claimant also needs or uses the items and services...

  18. Factors of Problem Behavior in Visually Impaired Children.

    Science.gov (United States)

    Schnittjer, Carl J.; Hirshoren, Alfred

    1981-01-01

    The Behavior Problem Checklist was completed by teachers of 104 students in a residential school for the visually impaired. Overall, the visually impaired children tended to have problem-behavior patterns similar to other populations and these patterns were largely independent of the visual handicap. (Author)

  19. Determinants of social participation of visually impaired older adults

    NARCIS (Netherlands)

    Alma, Manna A.; Van der Mei, Sijrike F.; Groothoff, Johan W.; Suurmeijer, Theo P. B. M.

    2012-01-01

    To assess determinants of social participation among visually impaired older adults. This cross-sectional study included visually impaired persons (a parts per thousand yen55 years; n = 173) who were referred to a low-vision rehabilitation center. Determinants (i.e., sociodemographic, physical, soci

  20. Attitudes of Visually Impaired Persons toward Cane Use.

    Science.gov (United States)

    Wainapel, S. F.

    1989-01-01

    Semistructured telephone interviews with 10 visually impaired adult cane users found that early negative attitudes of stigma were usually replaced by more positive attitudes and that there was a mean of 1 3/4 years between the onset of severe visual impairment and commencement of orientation and mobility training. (Author/DB)

  1. White Matter Damage and Cognitive Impairment after Traumatic Brain Injury

    Science.gov (United States)

    Kinnunen, Kirsi Maria; Greenwood, Richard; Powell, Jane Hilary; Leech, Robert; Hawkins, Peter Charlie; Bonnelle, Valerie; Patel, Maneesh Chandrakant; Counsell, Serena Jane; Sharp, David James

    2011-01-01

    White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent. In contrast, diffusion tensor imaging provides a validated and sensitive way of identifying the impact of axonal injury. The relationship between cognitive impairment after traumatic brain injury…

  2. Visual Impairment and Self-Esteem: What Makes a Difference?

    Science.gov (United States)

    Bowen, Jayne

    2010-01-01

    This account follows on from the research report "Visual impairment and its impact on self-esteem" (Bowen, 2010) published in this journal. The original article reported the results of an investigation of self-esteem levels amongst a sample group of 60 children with visual impairment. Four children, whose self-esteem was measured as "low" or "very…

  3. 38 CFR 3.385 - Disability due to impaired hearing.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Disability due to... Considerations Relative to Specific Diseases § 3.385 Disability due to impaired hearing. For the purposes of applying the laws administered by VA, impaired hearing will be considered to be a disability when...

  4. Awareness of deficits in mild cognitive impairment and Alzheimer's disease

    DEFF Research Database (Denmark)

    Vogel, Asmus; Stokholm, Jette; Gade, Anders;

    2004-01-01

    In this study we investigated impaired awareness of cognitive deficits in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Very few studies have addressed this topic, and methodological inconsistencies make the comparison of previous studies difficult. From a prospective...

  5. Semantic memory impairment in the earliest phases of Alzheimer's disease

    DEFF Research Database (Denmark)

    Vogel, Asmus; Gade, Anders; Stokholm, Jette;

    2005-01-01

    The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD...

  6. Access to electronic resources by visually impaired people

    OpenAIRE

    Jenny Craven

    2003-01-01

    Research into access to electronic resources by visually impaired people undertaken by the Centre for Research in Library and Information Management has not only explored the accessibility of websites and levels of awareness in providing websites that adhere to design for all principles, but has sought to enhance understanding of information seeking behaviour of blind and visually impaired people when using digital resources.

  7. The Oral Referential Communication Skills of Hearing-Impaired Children

    Science.gov (United States)

    Lloyd, Julian; Lieven, Elena; Arnold, Paul

    2005-01-01

    This paper focuses on the oral referential communication skills of hearing-impaired (HI) children. A task based on that used with language impaired children by Leinonen and Letts (1997) was used to assess the speaking and listening skills of 20 HI children (mean age=10;2 years; mean better ear average hearing loss=88.85 dBHL). Their performance…

  8. Factors Affecting the Reading Media Used by Visually Impaired Adults

    Science.gov (United States)

    Goudiras, Dimitrios B.; Papadopoulos, Konstantinos S.; Koutsoklenis, Athanasios Ch.; Papageorgiou, Virginia E.; Stergiou, Maria S.

    2009-01-01

    The aim of this study was to examine reading media (braille, cassettes, screen-reader, screen-magnifier, large print, low vision aids, CCTV) used by visually impaired adults. This article reports the results of a research project involving 100 people with visual impairment. The participants were interviewed and asked to fill in a questionnaire to…

  9. Hearing impairment and renal failure associated with RMND1 mutations

    DEFF Research Database (Denmark)

    Ravn, Kirstine; Neland, Mette; Wibrand, Flemming;

    2016-01-01

    RMND1 homopolymeric complex was highly impaired. The two siblings had a markedly milder phenotype and longer survival compared to previously reported patients. In addition, they had renal failure and hearing impairment. These two newly described patients contribute to delineation of the clinical...

  10. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis

    DEFF Research Database (Denmark)

    Frøkjaer, Vibe G; Strauss, Gitte I; Mehlsen, Jesper;

    2006-01-01

    .0+/-2.0 bpm) compared to the controls (21.7+/-2.2 bpm, p=0.001, Tukey' test). Systolic blood pressure fell during head-up tilt only in patients with severe cirrhosis. Our results imply that cerebral autoregulation was impaired in the most severe cases of liver cirrhosis, and that those with impaired cerebral...

  11. TMDLs (Total Maximum Daily Loads) for Bacteria Impairments

    OpenAIRE

    Benham, Brian Leslie, 1960-; Zeckoski, Sara C.

    2009-01-01

    When the concentration of bacteria exceeds the state-specified water-quality criteria, the water is deemed to have a bacteria or pathogen impairment. This publication explains how bacteria impairments are determined and how this relates to the TMDL process.

  12. Listening Skills Materials for Visually Impaired Students: Catalog.

    Science.gov (United States)

    Alber, Bernadette

    The catalog lists 24 commercially available listening skills materials for visually impaired students. Materials were selected for inclusion by a committee of educators for the visually impaired; some materials may require minimal modification (such as transcribing answer sheets into braille). An introduction describes seven functional areas of…

  13. Monterey Learning Systems: Improving Academic Achievement of Visually Impaired Learners

    Science.gov (United States)

    Daugherty, Kathryn M.

    1977-01-01

    Tested was the premise that the academic competencies of visually impaired learners could be enhanced by training procedures that combine auditory and visual skills in a project using the Monterey Learning Systems Reading and Mathematics Programs with 29 visually impaired print readers. (Author/MH)

  14. Cognitive impairment in affective psychoses: a meta-analysis.

    Science.gov (United States)

    Bora, Emre; Yücel, Murat; Pantelis, Christos

    2010-01-01

    It has recently been suggested that cognitive impairment should be included in the diagnostic criteria of schizophrenia. One of the main arguments in support of this suggestion has been the hope that cognitive impairment can help distinguish schizophrenia from bipolar disorder (BD). However, recent evidence shows that cognitive deficits occur in BD and persist beyond euthymia. Further, mood disorders with psychotic features might be expected to manifest greater cognitive impairment, which further complicates the potential to differentiate these disorders. The goal of the current meta-analysis was to examine the magnitude and characteristics of cognitive impairments in affective psychoses (AP). A systematic search of the existing literature sourced 27 studies that met the inclusion criteria. These studies compared cognitive performances of 763 patients with AP (550 BD and 213 major depressive disorder) and 1823 healthy controls. Meta-regression and subgroup analyses were used to examine the effects of moderator variables. Meta-analyses of these studies showed that patients with AP were impaired in all 15 cognitive tasks with large effect sizes for most measures. There were no significant differences between the magnitude of impairments between the BD and major depressive disorder groups. The largest effect size was found for symbol coding, stroop task, verbal learning, and category fluency, reflecting impairments in elementary and complex aspects of attentional processing, as well as learning and memory. In general, the pattern of cognitive impairments in AP was similar to reported findings in euthymic patients with BD, but relatively more pronounced. PMID:19767349

  15. Auditory Stream Biasing in Children with Reading Impairments

    Science.gov (United States)

    Ouimet, Tialee; Balaban, Evan

    2010-01-01

    Reading impairments have previously been associated with auditory processing differences. We examined "auditory stream biasing", a global aspect of auditory temporal processing. Children with reading impairments, control children and adults heard a 10 s long stream-bias-inducing sound sequence (a repeating 1000 Hz tone) and a test sequence (eight…

  16. Perceived social support in adolescents with and without visual impairment.

    Science.gov (United States)

    Pinquart, Martin; Pfeiffer, Jens P

    2013-11-01

    The study assessed perceived availability of support from parents, peers, and teachers in adolescents with and without visual impairment. Adolescents with visual impairment perceived lower levels of parental support but higher levels of support from teachers than sighted adolescents, and these differences remained stable across a 2-year interval. There was considerable heterogeneity within the groups as adolescents with visual impairment were most often found in clusters with high levels as well as low levels of all assessed sources of support. High perceived support from all sources showed positive associations with life-satisfaction of adolescents with and without visual impairment. As lower levels of perceived parental support of students with visual impairment were based on students from residential schools, we conclude that measures would be welcomed for improvement of parent-child contacts during the school days. PMID:24060727

  17. CONTEMPOPARY VIEWS TO SIGN LANGUAGE OF HEARING IMPAIRED

    Directory of Open Access Journals (Sweden)

    Bojka TATAREVA

    1998-04-01

    Full Text Available The place of the sign language in education of hearing impaired children in Denmark, USA and Sweden.Hearing impaired people ought to have a possibility of access to vital information, so they can move step by step, to live as useful members of society.Sign language is nonverbal communication which appears as a kind of compensation of the language lack, a means of development of that activity an opinion of unlimited human communicative nature.Mimic sign language in the system of education of hearing impaired children in Denmark, USA and Sweden take a primary place. The school with Hearing impaired children are bilingual. In the schools sign language is taken as a training language and it is available to every child.Contemporary views and practice tell us that teaching of hearing impaired children with sign language is more effective and more available.

  18. Aging neuromodulation impairs associative binding: a neurocomputational account.

    Science.gov (United States)

    Li, Shu-Chen; Naveh-Benjamin, Moshe; Lindenberger, Ulman

    2005-06-01

    Relative to young adults, older adults are particularly impaired in episodic memory tasks requiring associative binding of separate components into compound episodes, such as tasks requiring item-context and item-item binding. This associative-binding deficit has been attributed to senescent changes in frontal-hippocampal circuitry but has not been formally linked to impaired neuromodulation involving this circuitry. Previous neurocomputational work showed that impaired neuromodulation could result in less distinct neurocognitive representations. Here we extend this computational principle to simulate aging-related deficits in associative binding. As expected, networks with simulated deficiency in neuromodulation resulted in less distinct internal representations than did networks simulating the processing and performance of young adults, and were also more impaired under task conditions that required associative binding. The findings suggest that senescent changes in neuromodulatory mechanisms may play a basic role in aging-related impairment in associative binding by reducing the efficacy of distributed conjunctive coding. PMID:15943670

  19. Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

    DEFF Research Database (Denmark)

    Lemaire, Laurence A; Goulley, Joan; Kim, Yung Hae;

    2015-01-01

    that line the ducts during development, and in the ducts after birth, but not in differentiated endocrine or acinar cells. Genetic inactivation of Bicc1 leads to ductal cell over-proliferation and cyst formation. Transcriptome comparison between WT and Bicc1 KO pancreata, before the phenotype onset, reveals......(+) endocrine progenitor production. Its deletion leads to a late but sustained endocrine progenitor decrease, resulting in a 50% reduction of endocrine cells. We show that BICC1 functions downstream of ONECUT1 in the pathway controlling both NEUROG3(+) endocrine cell production and ductal morphogenesis......, and suggest a new candidate gene for syndromes associating kidney dysplasia with pancreatic disorders, including diabetes....

  20. Physical impairment aware transparent optical networks

    Science.gov (United States)

    Antona, Jean-Christophe; Morea, Annalisa; Zami, Thierry; Leplingard, Florence

    2009-11-01

    As illustrated by optical fiber and optical amplification, optical telecommunications have appeared for the last ten years as one of the most promising candidates to increase the transmission capacities. More recently, the concept of optical transparency has been investigated and introduced: it consists of the optical routing of Wavelength Division Multiplexed (WDM) channels without systematic optoelectronic processing at nodes, as long as propagation impairments remain acceptable [1]. This allows achieving less power-consuming, more scalable and flexible networks, and today partial optical transparency has become a reality in deployed systems. However, because of the evolution of traffic features, optical networks are facing new challenges such as demand for higher transmitted capacity, further upgradeability, and more automation. Making all these evolutions compliant on the same current network infrastructure with a minimum of upgrades is one of the main issues for equipment vendors and operators. Hence, an automatic and efficient management of the network needs a control plan aware of the expected Quality of Transmission (QoT) of the connections to set-up with respect to numerous parameters such as: the services demanded by the customers in terms of protection/restoration; the modulation rate and format of the connection under test and also of its adjacent WDM channels; the engineering rules of the network elements traversed with an accurate knowledge of the associated physical impairments. Whatever the method and/or the technology used to collect this information, the issue about its accuracy is one of the main concerns of the network system vendors, because an inaccurate knowledge could yield a sub-optimal dimensioning and so additional costs when installing the network in the field. Previous studies [1], [2] illustrated the impact of this knowledge accuracy on the ability to predict the connection feasibility. After describing usual methods to build

  1. Impairment in visual cognition in patients with Parkinson disease

    International Nuclear Information System (INIS)

    Neural pathway for visual information processing involves retina, lateral geniculate body, primary visual cortex, and higher visual cortical areas, all of which have been reported to be disordered either functionally or pathologically in Parkinson disease (PD). As elementary visual disorders, there have been studies that reported reduced contrast sensitivity for middle to high spatial frequencies and impaired blue color perception. Most of those studies suggested retina as the damaged cite that is responsible for the impairments, whereas some studies pointed to the possible cortical involvement. Impairments of higher visual functions also have been reported. In the dorsal stream, impairments of object localization, depth perception, and mental rotation have been reported. In the ventral stream, object perception and visual integration of objects have been found to be impaired. A meta-analysis study, however, concluded that although there may be impairments in higher order functions like attention and problem solving capacity there is no firm evidence for the impairments of higher visual functions. Neuroimaging studies have found a relationship between reduced metabolism centered in the parietal lobe and impaired performance in higher visual functions. Impaired identification of overlapping figures has been reported in dementia with Lewy bodies a disease that is akin to PD. Capacity to discriminate textured areas has been found to be damaged in PD. We conducted a fluorodeoxyglucose-positron emission tomography (FDG-PET) study to explore the relationship between brain metabolism and perception of overlapping figures, perception of shapes defined by texture differences and perception of subjective contours in PD. It revealed that there is a correlation between reduced activation in lateral occipital complex and impaired performance for these tasks, suggesting some compromised ventral rout functions. (author)

  2. Education Practices Incorporating Technologies in the Field of Visual Impairments at a Special Needs Education School for Orthopedically Impaired Children

    OpenAIRE

    Miyagi, Manabi; Amano, Kazuhiko; Shinya, Mikihide

    2015-01-01

    This paper reports on the use of technological applications for specific educationalvisual impairments at a special needs education school for orthopedically impaired children. Tactilegraphics and voice IC tag recorders were introduced as educational materials for students who haddifficulties in visual recognition and speech production. Compared with conventional educationalmaterials, these innovative technologies were expected to increase student interest and overallsatisfaction.

  3. Impaired nonspecific cellular immunity in experimental cholestasis.

    Science.gov (United States)

    Roughneen, P T; Drath, D B; Kulkarni, A D; Rowlands, B J

    1987-11-01

    The abilities of polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM), to demonstrate chemotaxis, phagocytosis, and superoxide release after bile duct ligation in the rat were investigated to determine the effect of cholestasis on nonspecific cellular immune mechanisms. Chemotactic response to C5a and FMLP, phagocytosis of 14C labeled Staphylococcus aureus, and zymosan-induced superoxide release were evaluated 21 days after bile duct ligation (BDL), sham operation, or in normal controls. Serum total bilirubin level was elevated after BDL (p less than 0.01). Chemotactic ability was similar to each group. PMN phagocytic uptake of 14C labeled Staphylococcus aureus was depressed in BDL (p less than 0.05). BDL rats exhibited impaired PAM phagocytic indices and improved PMN superoxide release (p less than 0.03). PAM superoxide release was similar in each study group. Alterations in phagocytic function with cholestasis are important deficits in nonspecific cellular immunity that may contribute to the high incidence of infective complications associated with obstructive jaundice. PMID:2823730

  4. Impaired Fracture Healing after Hemorrhagic Shock

    Directory of Open Access Journals (Sweden)

    Philipp Lichte

    2015-01-01

    Full Text Available Impaired fracture healing can occur in severely injured patients with hemorrhagic shock due to decreased soft tissue perfusion after trauma. We investigated the effects of fracture healing in a standardized pressure controlled hemorrhagic shock model in mice, to test the hypothesis that bleeding is relevant in the bone healing response. Male C57/BL6 mice were subjected to a closed femoral shaft fracture stabilized by intramedullary nailing. One group was additionally subjected to pressure controlled hemorrhagic shock (HS, mean arterial pressure (MAP of 35 mmHg for 90 minutes. Serum cytokines (IL-6, KC, MCP-1, and TNF-α were analyzed 6 hours after shock. Fracture healing was assessed 21 days after fracture. Hemorrhagic shock is associated with a significant increase in serum inflammatory cytokines in the early phase. Histologic analysis demonstrated a significantly decreased number of osteoclasts, a decrease in bone quality, and more cartilage islands after hemorrhagic shock. μCT analysis showed a trend towards decreased bone tissue mineral density in the HS group. Mechanical testing revealed no difference in tensile failure. Our results suggest a delay in fracture healing after hemorrhagic shock. This may be due to significantly diminished osteoclast recruitment. The exact mechanisms should be studied further, particularly during earlier stages of fracture healing.

  5. Computer interfaces for the visually impaired

    Science.gov (United States)

    Higgins, Gerry

    1991-01-01

    Information access via computer terminals extends to blind and low vision persons employed in many technical and nontechnical disciplines. Two aspects are detailed of providing computer technology for persons with a vision related handicap. First, research into the most effective means of integrating existing adaptive technologies into information systems was made. This was conducted to integrate off the shelf products with adaptive equipment for cohesive integrated information processing systems. Details are included that describe the type of functionality required in software to facilitate its incorporation into a speech and/or braille system. The second aspect is research into providing audible and tactile interfaces to graphics based interfaces. Parameters are included for the design and development of the Mercator Project. The project will develop a prototype system for audible access to graphics based interfaces. The system is being built within the public domain architecture of X windows to show that it is possible to provide access to text based applications within a graphical environment. This information will be valuable to suppliers to ADP equipment since new legislation requires manufacturers to provide electronic access to the visually impaired.

  6. NCOA4 Deficiency Impairs Systemic Iron Homeostasis

    Directory of Open Access Journals (Sweden)

    Roberto Bellelli

    2016-01-01

    Full Text Available The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, and decreased levels of duodenal ferroportin. Despite signs of iron overload, NCOA4-null mice had mild microcytic hypochromic anemia. Under an iron-deprived diet (2–3 mg/kg, mice failed to release iron from ferritin storage and developed severe microcytic hypochromic anemia and ineffective erythropoiesis associated with increased erythropoietin levels. When fed an iron-enriched diet (2 g/kg, mice died prematurely and showed signs of liver damage. Ferritin accumulated in primary embryonic fibroblasts from NCOA4-null mice consequent to impaired autophagic targeting. Adoptive expression of the NCOA4 COOH terminus (aa 239–614 restored this function. In conclusion, NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.

  7. Thal fundoplication in neurologically impaired children.

    Science.gov (United States)

    Ramachandran, V; Ashcraft, K W; Sharp, R J; Murphy, P J; Snyder, C L; Gittes, G K; Bickler, S W

    1996-06-01

    Children with neurological impairment (NI) frequently require feeding gastrostomy, and this often aggravates or produces gastroesophageal reflux (GER). From 1976 to 1994, 141 children with severe NI underwent Thal fundoplication and gastrostomy (GT). GER was evident in 80%; in the rest, fundoplication was an adjunct to GT. Ph results were positive in 38 cases, and 57 children had reflux according to the barium studies. There were no major intraoperative complications. Disruption of the repair and/or recurrent GER was noted in 14 cases (10%); 8 were redone as Thals, and 6 were converted to Nissen procedures. Pyloroplasty was done later in 9 children (6%). Bowel obstruction was seen in 4 patients (3%). Clinical follow-up (mean, 54 months) showed improvement in 96%; only 5 of the 141 (3.2%) have residual symptoms. Of the patients with an intact Thal, 67% could burp or vomit. The ability to vomit may protect the Thal fundoplication and avoid disruption of the repair. PMID:8783112

  8. Extinction memory is impaired in schizophrenia

    Science.gov (United States)

    Holt, Daphne. J.; Lebron-Milad, Kelimer; Milad, Mohammed R.; Rauch, Scott L.; Pitman, Roger K.; Orr, Scott P.; Cassidy, Brittany S.; Walsh, Jared P.; Goff, Donald C.

    2013-01-01

    Background Schizophrenia is associated with abnormalities in emotional processing and social cognition, which may result from disruption of the underlying neural mechanism(s) governing emotional learning and memory. To investigate this possibility, we measured the acquisition and extinction of conditioned fear responses and delayed recall of extinction in schizophrenia and control subjects. Methods 28 schizophrenia and 18 demographically-matched control subjects underwent a two-day fear conditioning, extinction learning and extinction recall procedure, in which skin conductance response (SCR) magnitude was used as the index of conditioned responses. Results During fear acquisition, 83% of the controls and 57% of the patients showed autonomic responsivity (‘responders’), and the patients showed larger SCRs to the stimulus that was not paired with the unconditioned stimulus (CS−) than the controls. Within the responder group, there was no difference between the patients and controls in levels of extinction learning; however, the schizophrenia patients showed significant impairment, relative to the controls, in context-dependent recall of the extinction memory. In addition, delusion severity in the patients correlated with baseline skin conductance levels. Conclusions These data are consistent with prior evidence for a heightened neural response to innocuous stimuli in schizophrenia and elevated arousal levels in psychosis. The finding of deficient extinction recall in schizophrenia patients who showed intact extinction learning suggests that schizophrenia is associated with a disturbance in the neural processes supporting emotional memory. PMID:18986648

  9. Impaired Fibrinolysis in the Antiphospholipid Syndrome

    Science.gov (United States)

    Krone, Katie A.; Allen, Kristi L.; McCrae, Keith R.

    2010-01-01

    The antiphospholipid syndrome (APS) is characterized by venous and/or arterial thrombosis, or recurrent fetal loss, in the presence of antiphospholipid antibodies (APL). The pathogenesis of APS is multifaceted and involves numerous mechanisms including activation of endothelial cells, monocytes, and/or platelets; inhibition of natural anticoagulant pathways such as protein C, tissue factor inhibitor, and annexin A5; activation of the complement system; and impairment of the fibrinolytic system. Fibrinolysis—the process by which fibrin thrombi are remodeled and degraded—involves the conversion of plasminogen to plasmin by tissue plasminogen activator (tPA) or urokinase-type plasminogen activator, and is tightly regulated. Although the role of altered fibrinolysis in patients with APS is relatively understudied, several reports suggest that deficient fibrinolytic activity may contribute to the pathogenesis of disease in these patients. This article discusses the function of the fibrinolytic system and reviews studies that have reported alterations in fibrinolytic pathways that may contribute to thrombosis in patients with APL. Some of these mechanisms include elevations in plasminogen activator inhibitor-1 levels, inhibitory antibodies against tPA or other components of the fibrinolytic system, antibodies against annexin A2, and finally, antibodies to β2-glycoprotein-I (β2GPI) that block the ability of β2GPI to stimulate tPA-mediated plasminogen activation. PMID:20425534

  10. Impaired glucose tolerance in sleep disorders.

    Directory of Open Access Journals (Sweden)

    Marietta Keckeis

    Full Text Available BACKGROUND: Recent epidemiological and experimental data suggest a negative influence of shortened or disturbed night sleep on glucose tolerance. Due to the high prevalence of sleep disorders this might be a major health issue. However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders. METHODOLOGY/PRINCIPAL FINDINGS: We performed oral glucose tolerance tests (OGTT and assessed additional parameters of carbohydrate metabolism in patients suffering from obstructive sleep apnea syndrome (OSAS, N = 25, restless legs syndrome (RLS, N = 18 or primary insomnia (N = 21, and in healthy controls (N = 33. Compared to controls, increased rates of impaired glucose tolerance were found in OSAS (OR: 4.9 and RLS (OR: 4.7 patients, but not in primary insomnia patients (OR: 1.6. In addition, HbA1c values were significantly increased in the same two patient groups. Significant positive correlations were found between 2-h plasma glucose values measured during the OGTT and the apnea-arousal-index in OSAS (r = 0.56; p<0.05 and the periodic leg movement-arousal-index in RLS (r = 0.56, p<0.05, respectively. Sleep duration and other quantitative aspects of sleep were similar between patient groups. CONCLUSIONS/SIGNIFICANCE: Our findings suggest that some, but not all sleep disorders considerably compromise glucose metabolism. Repeated arousals during sleep might be a pivotal causative factor deserving further experimental investigations to reveal potential novel targets for the prevention of metabolic diseases.

  11. Evaluation of functional impairment in psoriasis

    Directory of Open Access Journals (Sweden)

    Gaikwad Rohini

    2006-01-01

    Full Text Available Background: Psoriasis is a chronic disease, the course of which is punctuated by exacerbations and remissions. The impact of a chronic, relapsing, and disfiguring disease such as psoriasis on occupational, social, and other areas of functioning is substantial and needs attention. Aim: The purpose of this study was to assess the level and nature of functional impairment in psoriasis. Methods: Forty-three consecutive patients attending the dermatology clinic of a rural hospital were studied for psychiatric comorbidity and the level of functioning, using a semistructured questionnaire. Results: Psoriasis affected social functioning of 48% patients, led to decreased work efficiency in 51.1%, and to subjective distress at work in 62.8% of patients. Stress in home environment and interpersonal relationships was reported by 69.8%. Social and occupational functioning worsened with increasing severity of psoriasis after 1-year duration of illness. Patients complaining of pruritis frequently had anxiety disorders. Psychiatric comorbidity was detected in 67.4% cases. Conclusion : Substantial proportion of patients suffered deterioration of functioning, especially with increasing duration of illness. Thus, timely attention by dermatologists is needed in order to limit the disability caused by psoriasis. To achieve this, liaison with psychiatrist would be crucial along with illness education and emotional support.

  12. Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

    Directory of Open Access Journals (Sweden)

    Ganna Bilousova

    2005-12-01

    Full Text Available Impaired cell cycle progression can be paradoxically associated with increased rates of malignancies. Using retroviral transduction of bone marrow progenitors followed by transplantation into mice, we demonstrate that inhibition of hematopoietic progenitor cell proliferation impairs competition, promoting the expansion of progenitors that acquire oncogenic mutations which restore cell cycle progression. Conditions that impair DNA replication dramatically enhance the proliferative advantage provided by the expression of Bcr-Abl or mutant p53, which provide no apparent competitive advantage under conditions of healthy replication. Furthermore, for the Bcr-Abl oncogene the competitive advantage in contexts of impaired DNA replication dramatically increases leukemogenesis. Impaired replication within hematopoietic progenitor cell pools can select for oncogenic events and thereby promote leukemia, demonstrating the importance of replicative competence in the prevention of tumorigenesis. The demonstration that replication-impaired, poorly competitive progenitor cell pools can promote tumorigenesis provides a new rationale for links between tumorigenesis and common human conditions of impaired DNA replication such as dietary folate deficiency, chemotherapeutics targeting dNTP synthesis, and polymorphisms in genes important for DNA metabolism.

  13. Assessing depression related severity and functional impairment: the Overall Depression Severity and Impairment Scale (ODSIS.

    Directory of Open Access Journals (Sweden)

    Masaya Ito

    Full Text Available The Overall Depression Severity and Impairment Scale (ODSIS is a brief, five-item measure for assessing the frequency and intensity of depressive symptoms, as well as functional impairments in pleasurable activities, work or school, and interpersonal relationships due to depression. Although this scale is expected to be useful in various psychiatric and mental health settings, the reliability, validity, and interpretability have not yet been fully examined. This study was designed to examine the reliability, factorial, convergent, and discriminant validity of a Japanese version of the ODSIS, as well as its ability to distinguish between individuals with and without a major depressive disorder diagnosis.From a pool of registrants at an internet survey company, 2830 non-clinical and clinical participants were selected randomly (619 with major depressive disorder, 619 with panic disorder, 576 with social anxiety disorder, 645 with obsessive-compulsive disorder, and 371 non-clinical panelists. Participants were asked to respond to the ODSIS and conventional measures of depression, functional impairment, anxiety, neuroticism, satisfaction with life, and emotion regulation.Exploratory and confirmatory factor analysis of three split subsamples indicated the unidimensional factor structure of ODSIS. Multi-group confirmatory factor analysis showed invariance of factor loadings between non-clinical and clinical subsamples. The ODSIS also showed excellent internal consistency and test-retest intraclass correlation coefficients. Convergence and discriminance of the ODSIS with various measures were in line with our expectations. Receiver operating characteristic curve analyses showed that the ODSIS was able to detect a major depressive syndrome accurately.This study supports the reliability and validity of ODSIS in a non-western population, which can be interpreted as demonstrating cross-cultural validity.

  14. Episodic-like memory impairment in subtypes of mild cognitive impairment

    Czech Academy of Sciences Publication Activity Database

    Vlček, Kamil; Laczó, J.; Vajnerová, O.; Ort, Michael; Vyhnálek, M.; Hort, J.

    2007-01-01

    Roč. 2007, - (2007), s. 69-69. ISSN 0792-8483. [Annual general meeting of the European Brain and Behaviour Society /39./. 15.09.2007-19.09.2007, Trieste] R&D Projects: GA ČR(CZ) GA309/05/0693; GA ČR(CZ) GA309/06/1231; GA MŠk(CZ) 1M0517 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * mild cognitive impairment * spatial navigation * Alzheimer's disease Subject RIV: FH - Neurology

  15. EPA Office of Water (OW): 303(d) Listed Impaired Waters NHDPlus Indexed Dataset

    Data.gov (United States)

    U.S. Environmental Protection Agency — The 303(d) Listed Impaired Waters program system provides impaired water data and impaired water features reflecting river segments, lakes, and estuaries designated...

  16. Positivity effect specific to older adults with subclinical memory impairment.

    Science.gov (United States)

    Leal, Stephanie L; Noche, Jessica A; Murray, Elizabeth A; Yassa, Michael A

    2016-08-01

    Numerous studies have suggested that older adults preferentially remember positive information ("positivity effect"), however others have reported mixed results. One potential source of conflict is that aging is not a unitary phenomenon and individual differences exist. We modified a standard neuropsychological test to vary emotional content and tested memory at three time points (immediate/20 min/1 wk). Cognitively normal older adults were stratified into those with and without subclinical memory impairment. We found that the positivity effect was limited to those with subclinical memory impairment, suggesting that consideration of subclinical memory impairment is necessary for understanding age-related emotional memory alterations. PMID:27421893

  17. Glucocorticoids can induce PTSD-like memory impairments in mice.

    Science.gov (United States)

    Kaouane, Nadia; Porte, Yves; Vallée, Monique; Brayda-Bruno, Laurent; Mons, Nicole; Calandreau, Ludovic; Marighetto, Aline; Piazza, Pier Vincenzo; Desmedt, Aline

    2012-03-23

    Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition. PMID:22362879

  18. Concordance Rates for Cognitive Impairment among Older African American Twins

    OpenAIRE

    Whitfield, Keith E.; Kiddoe, Jared; Gamaldo, Alyssa; Andel, Ross; Christopher L Edwards

    2009-01-01

    We calculated concordance rates and heritability for cognitive impairment in 95 same-sexed pairs of African American twins from the Carolina African American Twin Study on Aging (CAATSA). The average age of the sample was 59.6 yrs (SD = 8.6 years, range 50–88 years) and 60% of the sample was female. The Telephone Interview for Cognitive Status (TICS) was used in the assessment of cognitive impairment. We lowered the cutoff for cognitive impairment based on our previous research with African A...

  19. The phenomenology of the intersubjective impairment.

    Science.gov (United States)

    Hipolito, Ines

    2016-08-01

    Several studies suggest that the disorders of the self include a disturbance of the most elementary component of self - the minimal self. Characterizing these disorders and understanding the mechanisms involved remain a challenge to medical epistemology and health care professionals. In the present work, I bring together concepts of different fields, such as neuroscience, epistemology and phenomenology. The main goal is to show that the second-person perspective can be used to point out particular features of social cognition and its related psychopathology. Taking the hypothesis that the second-person perspective is the congruence point between an objective process and the subjective experience, I will attempt to explain schizophrenia as a self-related deficit, first in the light of the first-person and the third-person perspective and afterward, in the light of the poorly less understood second-person perspective. On the one hand, the first-person experience is correlated both with space and time. In fact, psychiatric patients report subjective experiences that can be understood within research on the bodily self, such as (1) spatially incongruent proprioception and (2) impaired sense of time as the basic mechanism that allows conscious experience. On the other hand, the second-person approach has already begun to prove productive within social cognition research, pointing out the importance of experiencing and interacting with others as our primarily way well-being. I will phenomenological analyse subjective and intersubjective experience in the disorders of the self and derive practical consequences to evidence-based medicine. PMID:27237551

  20. Modeling Impaired Hippocampal Neurogenesis after Radiation Exposure.

    Science.gov (United States)

    Cacao, Eliedonna; Cucinotta, Francis A

    2016-03-01

    Radiation impairment of neurogenesis in the hippocampal dentate gyrus is one of several factors associated with cognitive detriments after treatment of brain cancers in children and adults with radiation therapy. Mouse models have been used to study radiation-induced changes in neurogenesis, however the models are limited in the number of doses, dose fractions, age and time after exposure conditions that have been studied. The purpose of this study is to develop a novel predictive mathematical model of radiation-induced changes to neurogenesis using a system of nonlinear ordinary differential equations (ODEs) to represent the time, age and dose-dependent changes to several cell populations participating in neurogenesis as reported in mouse experiments exposed to low-LET radiation. We considered four compartments to model hippocampal neurogenesis and, consequently, the effects of radiation treatment in altering neurogenesis: (1) neural stem cells (NSCs), (2) neuronal progenitor cells or neuroblasts (NB), (3) immature neurons (ImN) and (4) glioblasts (GB). Because neurogenesis is decreasing with increasing mouse age, a description of the age-related dynamics of hippocampal neurogenesis is considered in the model, which is shown to be an important factor in comparisons to experimental data. A key feature of the model is the description of negative feedback regulation on early and late neuronal proliferation after radiation exposure. The model is augmented with parametric descriptions of the dose and time after irradiation dependences of activation of microglial cells and a possible shift of NSC proliferation from neurogenesis to gliogenesis reported at higher doses (∼10 Gy). Predictions for dose-fractionation regimes and for different mouse ages, and prospects for future work are then discussed. PMID:26943452

  1. Impaired endothelial function in lone atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Polovina Marija

    2013-01-01

    Full Text Available Background/Aim. Impaired endothelial function has been previously documented in patients with atrial fibrillation (AF and underlying comorbidities or older patients with idiopathic AF. The aim of this study was to evaluate systemic endothelial function in younger AF patients (less than 7 days lone AF. The second group comprised of 28 healthy controls in sinus rhythm (the mean age 43 ± 13, 53% male, matched by age, gender and atherosclerotic risk factors. All the participants underwent physical examination, laboratory analysis [including determination of C-reactive protein (CRP], standard echocardiography and exercise-stress testing. Brachial artery FMD and endothelium independent dilation (NMD were assessed with a high-resolution ultrasound probe and arterial diameters taken from 5 consecutive cardiac cycles were averaged for each measurement to accommodate to beat-to-beat flow variations in AF. Results. There were no differences between the 2 groups regarding age, gender and most clinical, laboratory and echocardiographic characteristics (all p > 0.05, apart from the increased heart rate (p = 0.018, body mass index (p = 0.027, CRP levels (p = 0.007 and left atrial anteroposterior dimension (p 0.05. In the multivariate analysis, the independent FMD determinants in our study population were the presence of AF, smoking and total cholesterol levels (all p < 0.001. In patients with AF, the strongest independent FMD determinant was arrhythmia duration (p < 0.001, followed by smoking (p = 0.013 and total cholesterol levels (p = 0.045. Conclusions. Our findings confirm that sustained AF is associated with systemic endothelial dysfunction even in relatively young patients with no cardiovascular disorders or risk factors. AF is an independent contributor to lower FMD and a prolonged arrhythmia duration may confer the risk for more profound endothelial damage.

  2. Visual Impairment/Intracranial Pressure Risk Assessment

    Science.gov (United States)

    Fogarty, Jennifer A.; Durham, T.; Otto, C.; Grounds, D.; Davis, J. R.

    2010-01-01

    Since 2006 there have been 6 reported cases of altered visual acuity and intracranial pressure (ICP) in long duration astronauts. In order to document this risk and develop an integrated approach to its mitigation, the NASA Space Life Sciences Directorate (SLSD) and Human Research Program (HRP) have chosen to use the Human System Risk Board (HSRB) and the risk management analysis tool (RMAT). The HSRB is the venue in which the stakeholders and customers discuss and vet the evidence and the RMAT is the tool that facilitates documentation and comparison of the evidence across mission profiles as well as identification of risk factors, and documentation of mitigation strategies. This process allows for information to be brought forward and dispositioned so that it may be properly incorporated into the RMAT and contribute to the design of the research and mitigation plans. The evidence thus far has resulted in the identification of a visual impairment/intracranial pressure (VIIP) project team, updating of both short and long duration medical requirements designed to assess visual acuity, and a research plan to characterize this issue further. In order to understand this issue more completely, a plan to develop an Accelerated Research Collaboration (ARC) has been approved by the HSRB. The ARC is a novel research model pioneered by the Myelin Repair Foundation. It is a patient centered research model that brings together researchers and clinicians, under the guidance of a scientific advisory panel, to collaborate and produce results much quickly than accomplished through traditional research models. The data and evidence from the updated medical requirements and the VIIP ARC will be reviewed at the HSRB on a regular basis. Each review package presented to the HSRB will include an assessment and recommendation with respect to continuation of research, countermeasure development, occupational surveillance modalities, selection criteria, etc. This process will determine the

  3. Cause of impaired carbohydrate metabolism in hyperthyroidism

    International Nuclear Information System (INIS)

    Hyperthyroidism (HT) affects glucose metabolism in various ways. The role of insulin, glucagon and growth-hormone (GH) was determined. After glucose loading the insulin response is weaker in HT than in euthyroid subjects. Enhanced degradation of insulin has been reported. It is suggested that in HT the serum insulin concentration declines at a slightly accelerated rate. In HT the deranged carbohydrate metabolism might be a consequence of altered tissue sensitivity to insulin. To elucidate this problem insulin receptors on erythrocytes obtained from hyperthyroid women were investigated. The maximal specific binding of 125I-insulin to RBC of hyperthyroid patients was decreased and the analysis refers to a decreased receptor concentration in RBC. The nature of glucagon secretion and its influence on glucose metabolism in HT was investigated. The basal plasma glucagon is elevated in hyperthyroid patients. The suppression of glucagon secretion induced by an oral glucose loading was of significantly lesser degree in hyperthyroid patients than in controls. Applying the erythrocyte receptor assay a decreased specific binding of 125I-glucagon to RBC of hyperthyroid patients has been found and data indicate a significantly less glucagon receptor concentration in thyrotoxicosis. Physiological elevations of serum GH levels led to a significant impairment of glucose metabolism. Beside the GH-RH and somatostatin, the dopaminergic neurotransmitter system participates in the regulation of GH secretion too. It has been demonstrated that after administration of the dopamine agonist l-dopa the GH response was weaker in HT than in controls. This indicates that in thyrotoxicosis the GH secretion can not be stimulated in such a degree as in euthyroidism. (author)

  4. Nonmainstream dialect use and specific language impairment.

    Science.gov (United States)

    Oetting, J B; McDonald, J L

    2001-02-01

    Most work looking at specific language impairment (SLI) has been done in the context of mainstream dialects. This paper extends the study of SLI to two nonmainstream dialects: a rural version of Southern African American English (SAAE) and a rural version of Southern White English (SWE). Data were language samples from 93 4- to 6-year-olds who lived in southeastern Louisiana. Forty were classified as speakers of SAAE, and 53 were classified as speakers of SWE. A third were previously diagnosed as SLI; the others served as either age-matched (6N) or language-matched (4N) controls. The two dialects differed in frequency of usage on 14 of the 35 coded morphosyntactic surface patterns; speakers of these dialects could be successfully discriminated (94%) from each other in a discriminant analysis using just four of these patterns. Across dialects, four patterns resulted in main effects that were related to diagnostic condition (SLI vs. 6N), and a slightly different set of four patterns showed effects that were related to developmental processes (4N vs. 6N). More interestingly, the surface characteristics of SLI were found to manifest in the two dialects in different ways. A discriminant function based solely on SAAE speakers tended to misclassify SWE children with SLI as having normal language, and a discriminant function based on SWE speakers tended to misclassify SAAE unaffected children as SLI. Patterns within the SLI profile that cut across the two dialects included difficulties with tense marking and question formation. The results provide important direction for future studies and argue for the inclusion of contrastive as well as noncontrastive features of dialects within SLI research. PMID:11218104

  5. Impaired Hyperemic Response to Exercise Post Stroke.

    Directory of Open Access Journals (Sweden)

    Matthew J Durand

    Full Text Available Individuals with chronic stroke have reduced perfusion of the paretic lower limb at rest; however, the hyperemic response to graded muscle contractions in this patient population has not been examined. This study quantified blood flow to the paretic and non-paretic lower limbs of subjects with chronic stroke after submaximal contractions of the knee extensor muscles and correlated those measures with limb function and activity. Ten subjects with chronic stroke and ten controls had blood flow through the superficial femoral artery quantified with ultrasonography before and immediately after 10 second contractions of the knee extensor muscles at 20, 40, 60, and 80% of the maximal voluntary contraction (MVC of the test limb. Blood flow to the paretic and non-paretic limb of stroke subjects was significantly reduced at all load levels compared to control subjects even after normalization to lean muscle mass. Of variables measured, increased blood flow after an 80% MVC was the single best predictor of paretic limb strength, the symmetry of strength between the paretic and non-paretic limbs, coordination of the paretic limb, and physical activity. The impaired hemodynamic response to high intensity contractions was a better predictor of lower limb function than resting perfusion measures. Stroke-dependent weakness and atrophy of the paretic limb do not explain the reduced hyperemic response to muscle contraction alone as the response is similarly reduced in the non-paretic limb when compared to controls. These data may suggest a role for perfusion therapies to optimize rehabilitation post stroke.

  6. Neuropathology of mild cognitive impairment (MCI)

    International Nuclear Information System (INIS)

    Described are retrospective pathological studies on mild cognitive impairment (MCI) of brain specimens in the brain bank of authors' institute and current clinical studies of outpatients for screening of MCI based on those pathological findings. The study projects, aided by Ministry of Health, Labour and Welfare (MHLW) from 2003 and from 2007, have aimed to develop the optimal way for prophylaxis of dementia. In the former autopsy, about 10% of the elderly dead registered in the institute are found to have pathological changes of the clinical dementia rating 0.5, in whom the early Alzheimer disease (AD), Lewy body dementia, argentaffin granular disease and neurofibrillary tangle dominant disease are involved in a similar ratio to each other. Clinically, new patients with memory complaint are first screened by neurological tests involving CT, and then those with suspicious dementia undergo the second screening (2-day hospitalization) involving MRI with VSRAD (Voxel-based Specific Regional Analysis System for AD), ECD single photon emission computed tomography (SPECT) with eZis (easy Z-score imaging system), myocardial scintigraphy with homovanillic acid (HVA)/m-iodobenzylguanidine (MIBG), and if necessary, PET with fluorodeoxyglucose (FDG), PIB (Pittsburgh Compound B, an amyloid prove) and/or 11C-CFT and 11C-raclopride. Further, new patients with suspicious Parkinson disease undergo the screening (3-day) of various tests involving MRI with voxel-based morphometry and VSRAD, cerebral blood flow ECD SPECT with eZis and MIBG myocardial scintigraphy. It is concluded that AD is the most important subject in MCI and systemic diseases can also affect the cognitive ability as well. (R.T.)

  7. Multiple intranigral unilateral LPS infusion protocol generates a persistent cognitive impairment without cumulative dopaminergic impairment.

    Science.gov (United States)

    Delattre, Ana Marcia; Carabelli, Bruno; Mori, Marco Aurélio; Pudell, Claudia; da Silva, Danielle R B L; Menezes, Isabela; Kempe, Paula R G; Staziaki, Pedro Vinícius; Dombrowski, Patrícia A; da Cunha, Claudio; Lima, Marcelo M S; Ferraz, Anete C

    2013-11-01

    Inflammation in Parkinson's disease (PD) is a continuous process and might be implicated in the progression of neuronal degeneration. Taking this into account, we proposed a new protocol with multiple and consecutive intranigral lipopolysaccharide (LPS) administration in order to analyze its effects on cognitive behavior. Additionally, striatal concentrations of the neurotransmitters dopamine (DA) and serotonin and their respective metabolites were assessed in three different time-points with the purpose of identifying the consecutive and cumulative effects of LPS infusions. We demonstrated that with a minimum administered dose there was stabilization of neuronal damage as revealed by absence of synergic effect on DA concentration. Although the DA decrease (-43%) generates an animal model of early phase of PD, without apparent motor impairment, the LPS group exhibited deficit in episodic-like memory behavior from the first time-point until the last one, indicating persisted disturbances in memory-recognition responses. These findings provide evidence that multiple intranigral LPS infusions are not sufficient to cause cumulative and progressive damage to dopaminergic neurons, but confirm that the LPS model can be adopted as a useful tool providing insight about the cognitive impairment observed in pre-motor phase of PD. PMID:23844681

  8. Role of marine pollutants in impairment of DNA integrity.

    Digital Repository Service at National Institute of Oceanography (India)

    Sarker, S.; Sarkar, A.

    In this article, we present an overview on the role of marine pollutants in impairment of DNA integrity in marine gastropods exposed to xenobiotics released from various sources into the coastal ecosystem. We provide an insight into the impact...

  9. Voice and GPS Based Navigation System for Visually Impaired

    Directory of Open Access Journals (Sweden)

    Harsha Gawari

    2014-05-01

    Full Text Available The paper represents the architecture and implementation of a system that will help in the navigation of the visually impaired people. The system that we have designed uses GPS and voice recognition along with obstacle avoidance for the purpose of guiding visually impaired. The visually impaired person issues the command and receives the direction response using audio signals. The latitude and longitude values are received continuously from the GPS receiver. The directions are given to the user with the help of audio signals. An obstacle detector is used to help the user to avoid obstacles by sending an audio message.GPS receivers uses NMEA standard. With the advancement in voice recognition it becomes easier to issue commands regarding directions to the visually impaired.

  10. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

    OpenAIRE

    Kaushik, Susmita; Arias, Esperanza; Kwon, Hyokjoon; Lopez, Nuria Martinez; Athonvarangkul, Diana; Sahu, Srabani; Schwartz, Gary J.; Pessin, Jeffrey E.; Singh, Rajat

    2012-01-01

    Both selective loss of autophagy in POMC neurons and ageing decrease ?-melanocyte stimulating hormone levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. These effects can be pharmacologically alleviated, suggesting prevention strategies for obesity and metabolic syndrome.

  11. Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

    Directory of Open Access Journals (Sweden)

    Rebecca Sowers

    2011-01-01

    Full Text Available Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was adapted to evaluate methotrexate transport in 69 high-grade osteosarcoma tumor samples. All samples studied were shown to have relatively impaired methotrexate transport by PT430 assay. Ninety-nine percent of the samples had less than 20% PT430 displacement by methotrexate. Eighty-eight percent exhibited displacement by methotrexate at less than 50% of the displacement by trimetrexate. The high frequency of impaired transport suggests the presence of decreased functionality of the reduced folate carrier protein. The overwhelming presence of impaired transport may explain why methotrexate needs to be given in high doses to be effective in osteosarcoma therapy and suggests that reduced folate carrier-independent antifolates should be explored.

  12. Genetic Risk Score Predicts Late-Life Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Mariegold E. Wollam

    2015-01-01

    Full Text Available Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female, we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired. Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013 when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.

  13. Inflectional morphology in German hearing-impaired children.

    Science.gov (United States)

    Penke, Martina; Wimmer, Eva; Hennies, Johannes; Hess, Markus; Rothweiler, Monika

    2016-04-01

    Despite modern hearing aids, children with hearing impairment often have only restricted access to spoken language input during the 'critical' years for language acquisition. Specifically, a sensorineural hearing impairment affects the perception of voiceless coronal consonants which realize verbal affixes in German. The aim of this study is to explore if German hearing-impaired children have problems in producing and/or acquiring inflectional suffixes expressed by such phonemes. The findings of two experiments (an elicitation task and a picture-naming task) conducted with a group of hearing-impaired monolingual German children (age 3-4 years) demonstrate that difficulties in perceiving specific phonemes relate to the avoidance of these same sounds in speech production independent of the grammatical function these phonemes have. PMID:25175166

  14. Voice and GPS Based Navigation System For Visually Impaired

    Directory of Open Access Journals (Sweden)

    Harsha Gawari

    2014-04-01

    Full Text Available The paper represents the architecture and implementation of a system that will help to navigate the visually impaired people. The system designed uses GPS and voice recognition along with obstacle avoidance for the purpose of guiding visually impaired. The visually impaired person issues the command and receives the direction response using audio signals. The latitude and longitude values are received continuously from the GPS receiver. The directions are given to the user with the help of audio signals. An obstacle detector is used to help the user to avoid obstacles by sending an audio message.GPS receivers use NMEA standard. With the advancement in voice recognition it becomes easier to issue commands regarding directions to the visually impaired.

  15. Auditory spatial localization: Developmental delay in children with visual impairments.

    Science.gov (United States)

    Cappagli, Giulia; Gori, Monica

    2016-01-01

    For individuals with visual impairments, auditory spatial localization is one of the most important features to navigate in the environment. Many works suggest that blind adults show similar or even enhanced performance for localization of auditory cues compared to sighted adults (Collignon, Voss, Lassonde, & Lepore, 2009). To date, the investigation of auditory spatial localization in children with visual impairments has provided contrasting results. Here we report, for the first time, that contrary to visually impaired adults, children with low vision or total blindness show a significant impairment in the localization of static sounds. These results suggest that simple auditory spatial tasks are compromised in children, and that this capacity recovers over time. PMID:27002960

  16. Assessed Clean Water Act 305(b) Water Sources of Impairment

    Data.gov (United States)

    U.S. Environmental Protection Agency — Identifies the sources of impairment for assessed waters under the Clean Water Act 305(b) program. This view can be used for viewing the details at the assessment...

  17. Identity Crisis of Teenagers with Hearing Impairment in Palestine

    Directory of Open Access Journals (Sweden)

    Suheir .S. Sabbah

    2014-08-01

    Full Text Available This study aimed at identifying the degree of identity crises of teenagers with hearing impairment and the levels of the dimensions of this crises and revealing the impact of the following variables: gender, grade, economic level, age, degree and nature of the difficulty on the degree of the identity crisis. The results showed the identity crisis of the teenagers with hearing impairment was. Ideological Ego Identity, Interpersonal Ego Identity, relation with the other sex, and Identity verses role confusion. There were statistically significant differences in the identity crisis of the teenagers with hearing impairment attributed to the variables: gender in favor the category (18-20 years and the degree of disability in favor of the moderate disability. There were no differences in the identity crisis of the teenagers with hearing impairment attributed to the variables (gender, grade, economic situation and nature of the disability.

  18. 45 CFR 1308.17 - Eligibility criteria: Other impairments.

    Science.gov (United States)

    2010-10-01

    ... areas: physical development, cognitive development, communication development, social or emotional... classified as deaf-blind, whose concomitant hearing and visual impairments cause such severe communication... for deaf or blind children are eligible for services under this category. (e) Children classified...

  19. Mild Cognitive Impairment and Progession to Dementia: New Findings

    Science.gov (United States)

    ... mild cognitive impairment cases who revert to normal. Neurology 2014;82:317 – 325. 2. Norton M, Breitner ... 42:1252 – 1256. e34 © 2014 American Academy of Neurology PATIENT PAGE Section Editors David C. Spencer, MD ...

  20. Cognitive impairment and self-care in heart failure

    Directory of Open Access Journals (Sweden)

    Hajduk AM

    2013-10-01

    Full Text Available Alexandra M Hajduk,1,2 Stephenie C Lemon,3 David D McManus,1,2,4 Darleen M Lessard,1 Jerry H Gurwitz,1,2,4 Frederick A Spencer,5 Robert J Goldberg,1,2 Jane S Saczynski1,2,4 1Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; 2Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA; 3Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; 4Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; 5Department of Medicine, McMaster University, Hamilton, ON, Canada Background: Heart failure (HF is a prevalent chronic disease in older adults that requires extensive self-care to prevent decompensation and hospitalization. Cognitive impairment may impact the ability to perform HF self-care activities. We examined the association between cognitive impairment and adherence to self-care in patients hospitalized for acute HF. Design: Prospective cohort study. Setting and participants: A total of 577 patients (mean age = 71 years, 44% female hospitalized for HF at five medical centers in the United States and Canada. Measurements and methods: Participants were interviewed for information on self-reported adherence to self-care using the European Heart Failure Self-care Behaviour Scale. We assessed cognitive impairment in three domains (memory, processing speed, and executive function using standardized measures. Patients' demographic and clinical characteristics were obtained through medical record review. Multivariable linear regression was used to examine the association between cognitive impairment and self-care practices adjusting for demographic and clinical factors. Results: A total of 453 patients (79% were impaired in at least one cognitive

  1. How do firms implement impairment tests of goodwill?

    OpenAIRE

    Petersen, Christian; Plenborg, Thomas

    2007-01-01

    Adopting a survey approach, our study examines how firms implement impairment test of goodwill. We focus on how firms define and measure the recoverable amount of CGU. The survey includes 58 completed questionnaires representing 73% of the firms on the Copenhagen Stock Exchange that recognise goodwill in the balance sheet. Our survey generally supports that a common practice on impairment tests of goodwill has not yet been established. Based on our analysis it is difficult to determine wheth...

  2. Determinants of social participation of visually impaired older adults

    OpenAIRE

    Alma, Manna A.; Van der Mei, Sijrike F.; Groothoff, Johan W; Suurmeijer, Theo P. B. M.

    2012-01-01

    Purpose To assess determinants of social participation among visually impaired older adults. Methods This cross-sectional study included visually impaired persons (≥55 years; n = 173) who were referred to a low-vision rehabilitation center. Determinants (i.e., sociodemographic, physical, social and psychological factors, and personal values) of participation were identified in four domains of participation: (1) domestic life; (2) interpersonal interactions and relationships; (3) major life ar...

  3. Ettlinger revisited: the relation between agnosia and sensory impairment.

    OpenAIRE

    De Haan, E H; Heywood, C A; Young, A. W.; Edelstyn, N; Newcombe, F

    1995-01-01

    The concept of agnosia as a higher order functional impairment, which can occur in the absence of low level visual perceptual deficits, continues to provoke debate. This controversy is complicated by the fact that, on close examination, agnosic patients do tend to have some perceptual difficulties. Thus the issue centres around the question as to whether these deficits play a causal part in the aetiology of agnosia or whether they are functionally independent, with both impairments resulting ...

  4. The biological basis of language: insight from developmental grammatical impairments

    OpenAIRE

    van der Lely, Heather K. J.; Pinker, Steven

    2014-01-01

    Specific language impairment (SLI), a genetic developmental disorder, offers insights into the neurobiological and computational organization of language. A subtype, Grammatical-SLI (G-SLI), involves greater impairments in ‘extended’ grammatical representations, which are nonlocal, hierarchical, abstract, and composed, than in ‘basic’ ones, which are local, linear, semantic, and holistic. This distinction is seen in syntax, morphology, and phonology, and may be tied to abnormalities in the le...

  5. INCLUSIVE EDUCATION OF BLIND AND VISUALLY IMPAIRED PUPILS IN SLOVENIA

    OpenAIRE

    Cankar, Franc; Deutsch, Tomi; GLOBACNIK Bojana; PINTERIC Andreja

    2015-01-01

    Introduction: In the last years, the demand to include children with special needs in the mainstream kindergartens and schools in Slovenia has grown. This brought with it the need for changing the role of the special schools and institutes for children with special needs and for their transformation into resource centres. Methodology: We pilot tested a resource centre for support of blind and visually impaired children. We included 15 educational institutes and one blind or visually impair...

  6. Working memory and reward association learning impairments in obesity

    OpenAIRE

    Coppin, Géraldine; Nolan-Poupart, Sarah; Jones-Gotman, Marilyn; Small, Dana M.

    2014-01-01

    Obesity has been associated with impaired executive functions including working memory. Less explored is the influence of obesity on learning and memory. In the current study we assessed stimulus reward association learning, explicit learning and memory and working memory in healthy weight, overweight and obese individuals. Explicit learning and memory did not differ as a function of group. In contrast, working memory was significantly and similarly impaired in both overweight and obese indiv...

  7. Attentional and executive impairments in children with spastic cerebral palsy

    DEFF Research Database (Denmark)

    Bottcher, Louise; Flachs, Esben Meulengracht; Uldall, Peter

    2010-01-01

    Children with cerebral palsy (CP) are reported to have learning and social problems. The aim of the present study was to examine whether children with CP have impairments in attention or executive function.......Children with cerebral palsy (CP) are reported to have learning and social problems. The aim of the present study was to examine whether children with CP have impairments in attention or executive function....

  8. Verbal memory impairments in schizophrenia associated with cortical thinning

    Directory of Open Access Journals (Sweden)

    S. Guimond

    2016-01-01

    Full Text Available Verbal memory (VM represents one of the most affected cognitive domains in schizophrenia. Multiple studies have shown that schizophrenia is associated with cortical abnormalities, but it remains unclear whether these are related to VM impairments. Considering the vast literature demonstrating the role of the frontal cortex, the parahippocampal cortex, and the hippocampus in VM, we examined the cortical thickness/volume of these regions. We used a categorical approach whereby 27 schizophrenia patients with ‘moderate to severe’ VM impairments were compared to 23 patients with ‘low to mild’ VM impairments and 23 healthy controls. A series of between-group vertex-wise GLM on cortical thickness were performed for specific regions of interest defining the parahippocampal gyrus and the frontal cortex. When compared to healthy controls, patients with ‘moderate to severe’ VM impairments revealed significantly thinner cortex in the left frontal lobe, and the parahippocampal gyri. When compared to patients with ‘low to mild’ VM impairments, patients with ‘moderate to severe’ VM impairments showed a trend of thinner cortex in similar regions. Virtually no differences were observed in the frontal area of patients with ‘low to mild’ VM impairments relative to controls. No significant group differences were observed in the hippocampus. Our results indicate that patients with greater VM impairments demonstrate significant cortical thinning in regions known to be important in VM performance. Treating VM deficits in schizophrenia could have a positive effect on the brain; thus, subgroups of patients with more severe VM deficits should be a prioritized target in the development of new cognitive treatments.

  9. Guideline for the development of products for visually impaired

    OpenAIRE

    Ana Carolina Richter do Nascimento; Carlos Cziulik

    2013-01-01

    The concern about the needs of disabled people has grown, worldwide and in Brazil. The government seeks to address this issue. Visually impaired people represent 48,1% of the disabled person group in Brazil. Brazilian products that are used by visually impaired people are not developed specifically for this group and this fact is a big gap. Predominantly, product development approaches do not study methodologies to design products for people that can not see. Therefore, the objective of this ...

  10. Association of family history and consanguinity with permanent hearing impairment

    OpenAIRE

    Heramba Ganapathy Selvarajan; Ravi Kumar Arunachalam; Rajashekar Bellur; Kalyani Mandke; Roopa Nagarajan

    2013-01-01

    Background: Risk factors for hearing impairment can offer important information for both the family and health-care providers regarding etiology, other associated health problems, and risk of recurrence in sub-sequent pregnancy. Family history and consanguinity indicates the possible involvement of genetic factors. Objective: The aim of the study is to find the strength of association of family history and consanguinity with permanent hearing impairment in infants. Materials and Methods: A ca...

  11. Access to electronic resources by visually impaired people

    Directory of Open Access Journals (Sweden)

    Jenny Craven

    2003-01-01

    Full Text Available Research into access to electronic resources by visually impaired people undertaken by the Centre for Research in Library and Information Management has not only explored the accessibility of websites and levels of awareness in providing websites that adhere to design for all principles, but has sought to enhance understanding of information seeking behaviour of blind and visually impaired people when using digital resources.

  12. Education Differences in Life Expectancy With Cognitive Impairment

    OpenAIRE

    Matthews, Fiona E.; Jagger, Carol; Miller, Laura L; Brayne, Carol; ,

    2009-01-01

    Background Low education has an impact on life expectancy and level of cognition, but little is known on its effect on life expectancy with cognitive impairment. Methods The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) collected population-based longitudinal data on people aged 65 years and older including measures of education and cognitive impairment, using the Mini-Mental State Examination (MMSE), for five geographically diverse areas around England and Wales int...

  13. Elements of successful communication skills of people with visually impaired

    OpenAIRE

    Zlodej, Marsela

    2013-01-01

    The main topic of the thesis are the answers to the questions, what are the factors of successful communication of persons with visual impairment, and what are the beliefs about communicating that affect on successful communication. The systematic review of the literature identifies communication as a concept and the specification of communication of people with visual impairment. Irrational beliefs are defined; what they are and why they arise. Some ways of learning communication of persons ...

  14. Enhancing Color Representation for the Color Vision Impaired

    OpenAIRE

    Huang, Jia-Bin; Wu, Sih-Ying; Chen, Chu-Song

    2008-01-01

    In this paper, we propose a fast re-coloring algorithm to improve the accessibility for the color vision impaired. Compared to people with normal color vision, people with color vision impairment have difficulty in distinguishing between certain combinations of colors. This may hinder visual communication owing to the increasing use of colors in recent years. To address this problem, we re-map the hue components in the HSV color space based on the statistics of local characteristics of the or...

  15. Cognitive impairments after critical illness. Methodology, incidences and consequences

    OpenAIRE

    Torgersen, Johan

    2011-01-01

    Brain dysfunction describes the wide range of alterations in brain function from persistent vegetative state to minor cognitive impairments. It has become evident that brain dysfunctions that arise during an intensive care unit (ICU) stay are associated with mortality, morbidity, post-ICU functional status and rehabilitation. Brain dysfunction in ICU patients is therefore of major interest both in clinical practice and research. Cognitive impairment is one of several types o...

  16. Wearable Obstacle Detection System for visually impaired People

    OpenAIRE

    Cardin, S; Vexo, F.; Thalmann, D

    2005-01-01

    This paper presents an obstacle detection system for visually impaired people. User can be alerted of closed obstacles in range while traveling in their environment. The system we propose detects the nearest obstacle via a stereoscopic sonar system and sends back vibro-tactile feedback to inform the user about its localization. The system aims at increasing the mobility of visually impaired people by offering new sensing abilities.

  17. iShoes for blind and visually impaired people

    OpenAIRE

    Assairi, Bandar; Holmes, Violeta

    2013-01-01

    This paper presents the development of an iShoes system for blind and visually impaired people. The iShoes system utilizes a microcontroller with sound output interfaced with ultrasonic sensors. The prototype system is designed to be specifically mounted on/in the shoes to aid navigation in urban routes. The ultrasonic transducers determine the range from an obstacle and then play an audio message to reflect the distance from the target. This system will assist blind and visually impaired peo...

  18. Promoting Hope in Visually Impaired Patients in Finland

    OpenAIRE

    Guo, Jiaojiao; Popa, Diana

    2014-01-01

    The aim of this study was to explore the benefits of hope promotion in visually impaired patients in Finland, since there is insufficient information on the topic. The purpose was to develop teaching material for the students in Tampere University of Applied Sciences. The product provides evidence-based recommendations for nurses to build hope in visually impaired patients. The findings reveal that hope is a crucial element in the recovery process. The major aspects of building hope in v...

  19. Behavioral and Neurophysiological Signatures of Benzodiazepine-Related Driving Impairments.

    Science.gov (United States)

    Stone, Bradly T; Correa, Kelly A; Brown, Timothy L; Spurgin, Andrew L; Stikic, Maja; Johnson, Robin R; Berka, Chris

    2015-01-01

    Impaired driving due to drug use is a growing problem worldwide; estimates show that 18-23.5% of fatal accidents, and up to 34% of injury accidents may be caused by drivers under the influence of drugs (Drummer et al., 2003; Walsh et al., 2004; NHTSA, 2010). Furthermore, at any given time, up to 16% of drivers may be using drugs that can impair one's driving abilities (NHTSA, 2009). Currently, drug recognition experts (DREs; law enforcement officers with specialized training to identify drugged driving), have the most difficult time with identifying drivers potentially impaired on central nervous system (CNS) depressants (Smith et al., 2002). The fact that the use of benzodiazepines, a type of CNS depressant, is also associated with the greatest likelihood of causing accidents (Dassanayake et al., 2011), further emphasizes the need to improve research tools in this area which can facilitate the refinement of, or additions to, current assessments of impaired driving. Our laboratories collaborated to evaluate both the behavioral and neurophysiological effects of a benzodiazepine, alprazolam, in a driving simulation (miniSim(TM)). This drive was combined with a neurocognitive assessment utilizing time synched neurophysiology (electroencephalography, ECG). While the behavioral effects of benzodiazepines are well characterized (Rapoport et al., 2009), we hypothesized that, with the addition of real-time neurophysiology and the utilization of simulation and neurocognitive assessment, we could find objective assessments of drug impairment that could improve the detection capabilities of DREs. Our analyses revealed that (1) specific driving conditions were significantly more difficult for benzodiazepine impaired drivers and (2) the neurocognitive tasks' metrics were able to classify "impaired" vs. "unimpaired" with up to 80% accuracy based on lane position deviation and lane departures. While this work requires replication in larger studies, our results not only identified

  20. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment

    OpenAIRE

    Vasconcelos, Andrea R; Yshii, Lidia M; Viel, Tania A; Buck, Hudson S; Mark P Mattson; Scavone, Cristoforo; Kawamoto, Elisa M

    2014-01-01

    Background Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury and disease by stimulating adaptive cellular stress responses. However, the impact of IF on the cognitive sequelae of systemic and brain inflammation is unknown. Methods Rats on ...