Sample records for bibenzyl

  1. A new bibenzyl derivative from Pleione bulbocodioides

    Institute of Scientific and Technical Information of China (English)

    Xin Qiao Liu; Qiao Yu Yuan; Yuan Qiang Guo


    A new bibenzyl derivative 1, named 2-(4"-hydrixybenzyl)-3-(3'-hydroxyphenethyl)-5-methoxy-cyclohexa-2,5-diene-1,4-dione, and two known stilbenoids (2, 3) were isolated from the tubers of Pleione bulbocodioides (Franch.) Rolfe. Their structureswere elucidated by spectroscopic methods.2008 Xin Qiao Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  2. Testing a new NIF neutron time-of-flight detector with a bibenzyl scintillator on OMEGA. (United States)

    Glebov, V Yu; Forrest, C; Knauer, J P; Pruyne, A; Romanofsky, M; Sangster, T C; Shoup, M J; Stoeckl, C; Caggiano, J A; Carman, M L; Clancy, T J; Hatarik, R; McNaney, J; Zaitseva, N P


    A new neutron time-of-flight (nTOF) detector with a bibenzyl crystal as a scintillator has been designed and manufactured for the National Ignition Facility (NIF). This detector will replace a nTOF20-Spec detector with an oxygenated xylene scintillator currently operational on the NIF to improve the areal-density measurements. In addition to areal density, the bibenzyl detector will measure the D-D and D-T neutron yield and the ion temperature of indirect- and direct-drive-implosion experiments. The design of the bibenzyl detector and results of tests on the OMEGA Laser System are presented.

  3. Rapid Identification of Bibenzyls of Stemona sessilifolia using Hyphenated LC-UV-NMR and LC-MS Methods

    Institute of Scientific and Technical Information of China (English)


    As a part of the ongoing search for new constituents of Stemona species in China, chemical investigation of Stemona sessilifolia, a plant used in the traditional Chinese medicine to treat respiratory disorders, was carried out. To identify the chemical components rapidly, a selected sample of S. sessilifolia containing bibenzyls was tested using LC-ESIMS and analyzed further using stop-flow LC-UV-NMR, which was sensitive for the detection of the main constituents. LC microfractions were collected using the LC-UV-NMR technique and HR-EIMS off-line analysis was carried out on the collected fractions. This chemical screening strategy allowed for the on-line identification of the main constituents of S. sessilifolia and provided information that was useful for a further peak-guided isolation procedure.Using these methods, four bibenzyls were isolated: two known compounds, 3,5-dihydroxy-4-methyl bibenzyl(1) and 3,5-dihydroxy-2'-methoxy-4-methyl bibenzyl ( 2 ), and two novel compounds, 3, 3'-dihydroxy-5, 6'-dimethoxy bibenzyl (3) and 3,5-dihydroxy-2' ,5'-dimethoxy bibenzyl (4).

  4. Effect of plagiochin E, an antifungal macrocyclic bis(bibenzyl), on cell wall chitin synthesis in Candida albicans

    Institute of Scientific and Technical Information of China (English)

    Xiu-zhen WU; Ai-xia CHENG; Ling-mei SUN; Hong-xiang LOU


    Aim: To investigate the effect of plagiochin E (PLE), an antifungal macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L, on cell wall chitin synthesis in Candida albicans. Methods: The effect of PLE on chitin synthesis in Candida albicans was investigated at the cellular and molecular lev-els. First, the ultrastructural changes were observed under transmission electron microscopy (TEM). Second, the effects of PLE on chitin synthetase (Chs) activi-ties in vitro were assayed using 6-O-dansyl-N-acetylglucosamine as a fluorescent substrate, and its effect on chitin synthesis in situ was assayed by spheroplast regeneration. Finally, real-time RT-PCR was performed to assay its effect on the expression of Chs genes (CHS). Results: Observation under TEM showed that the structure of the cell wall in Candida albicans was seriously damaged, which suggested that the antifungal activity of PLE was associated with its effect on the cell wail. Enzymatic assays and spheroplast regeneration showed that PLE inhibited chitin synthesis in vitro and in situ. The results of the PCR showed that PLE significantly downregulated the expression of CHS1, and upregulated the expression of CHS2 and CHS3. Because different Chs is regulated at different stages of transcription and post-translation, the downregulation of CHS1 would decrease the level of Chs 1 and inhibit its activity, and the inhibitory effects of PLE on Chs2 and Chs3 would be at the post-translational level or by the inhibi-tion on the enzyme-active center. Conclusion: These results indicate that the antifungal activity of PLE would be attributed to its inhibitory effect on cell wall chitin synthesis in Candida albicans.

  5. Catalyst system and process for benzyl ether fragmentation and coal liquefaction (United States)

    Zoeller, Joseph Robert


    Dibenzyl ether can be readily cleaved to form primarily benzaldehyde and toluene as products, along with minor amounts of bibenzyl and benzyl benzoate, in the presence of a catalyst system comprising a Group 6 metal, preferably molybdenum, a salt, and an organic halide. Although useful synthetically for the cleavage of benzyl ethers, this cleavage also represents a key model reaction for the liquefaction of coal; thus this catalyst system and process should be useful in coal liquefaction with the advantage of operating at significantly lower temperatures and pressures.

  6. Impact of an atmospheric argon plasma jet on a dielectric surface and desorption of organic molecules (United States)

    Damany, Xavier; Pasquiers, Stéphane; Blin-Simiand, Nicole; Bauville, Gérard; Bournonville, Blandine; Fleury, Michel; Jeanney, Pascal; Santos Sousa, João


    The propagation of a DC-pulsed argon plasma jet through the surrounding ambient air, and its interaction with an ungrounded glass plate placed on the jet trajectory, was studied by means of fast imaging. The surface plays an important role in the spatio-temporal characteristics of the plasma. Indeed, for an argon jet propagating perpendicularly to the surface, the plasma jet structure changes from filamentary to diffuse when the distance between the nozzle of the capillary tube and the surface is short (≤10 mm). Changing the angle between the capillary tube and the glass plate, and varying the gas flow rate strongly affects the spatial extension of the plasma that develops on the surface. This surface plasma propagates while the plasma in the argon jet is maintained with the same luminous intensity. Finally, this plasma jet shows interesting characteristics for desorption of low volatile organic molecules such as bibenzyl. A maximum removal of bibenzyl is located at the intersection area between the jet axis and the glass surface, and some of the initially deposited molecules are found intact in gas phase. Contribution to the topical issue "6th Central European Symposium on Plasma Chemistry (CESPC-6)", edited by Nicolas Gherardi, Ester Marotta and Cristina Paradisi

  7. Chemical structures and reactivities of coal as an organic natural product

    Energy Technology Data Exchange (ETDEWEB)

    Collins, C J; Hombach, H P; Benjamin, B M; Roark, W H; Maxwell, B; Raaen, V F


    Some chemical reactions involved in coal liquefaction have been studied using carbon 14 labelled compounds and nuclear magnetic resonance. On the basis of these studies it is concluded that the role of tetralin during coal conversion is (1) to act as a dispersion vehicle; (2) to supply hydrogen radicals, when needed, to trap coal radicals, and (3) in a very minor way to undergo intermolecular reaction with the coal through making and breaking of C--C (and possibly other) bonds. As a result of other experiments it is concluded that to the methods previously employed for breaking bonds in coal molecules and thereby lowering their molecular weights, must now be added the use of solvated-electrons for breaking -CH/sub 2/--CH/sub 2/- linkages. A possible mechanism for the cleavage of bibenzyl (used as a model compound for coal) is given. (LTN)

  8. Thermal decomposition of allylbenzene ozonide

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, J.C.; Church, D.F.; Pryor, W.A. (Louisiana State Univ., Baton Rouge (USA))


    Thermal decomposition of allylbenzene ozonide (ABO) at 98{degree}C in the liquid phase yields toluene, bibenzyl, phenylacetaldehyde, formic acid, and (benzyloxy)methyl formate as major products; benzyl chloride is formed when chlorinated solvents are employed. These products, as well as benzyl formate, are formed when ABO is decomposed at 37{degree}C. When the decomposition of ABO is carried out in the presence of 1-butanethiol, the product distribution changes: yields of toluene increase, no bibenzyl is formed, and decreases in yields of (benzyloxy)methyl formate, phenylacetladehyde, and benzyl chloride are observed. The decomposition of 1-octene ozonide (OTO) also was studied for comparison. The activation parameters for both ABO and OTO are similar (28.2 kcal/mol, log A = 13.6 and 26.6 kcal/mol, log A = 12.5, respectively); these data suggest that ozonides decompose by homolysis of the O-O bond, rather than by an alternative synchronous two-bond scission process. When ABO is decomposed at 37{degree}C in the presence of the spin traps 5,5-dimethyl-1-pyrroline N-oxide (DMPO) or 3,3,5,5-tetramethyl-1-pyrroline N-oxide (M{sub 4}PO), ESR signals are observed that are consistent with the trapping of benzyl and other carbon- and oxygen-centered radicals. A mechanism for the thermal decomposition of ABO that involves peroxide bond homolysis and subsequent {beta}-scission is proposed. Thus, Criegee ozonides decompose to give free radicals at quite modest temperatures.

  9. Novel bimetallic dispersed catalysts for temperature-programmed coal liquefaction. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Chunshan Song; Schobert, H.H.; Parfitt, D.P. [and others


    Development of new catalysts is a promising approach to more efficient coal liquefaction. It has been recognized that dispersed catalysts are superior to supported catalysts for primary liquefaction of coals, because the control of initial coal dissolution or depolymerization requires intimate contact between the catalyst and coal. This research is a fundamental and exploratory study on catalytic coal liquefaction, with the emphasis on exploring novel bimetallic dispersed catalysts for coal liquefaction and the effectiveness of temperature-programmed liquefaction using dispersed catalysts. The primary objective of this research was to explore novel bimetallic dispersed catalysts from organometallic molecular precursors, that could be used in low concentrations but exhibit relatively high activity for efficient hydroliquefaction of coals under temperature-programmed conditions. We have synthesized and tested various catalyst precursors in liquefaction of subbituminous and bituminous coals and in model compound studies to examine how do the composition and structure of the catalytic precursors affect their effectiveness for coal liquefaction under different reaction conditions, and how do these factors affect their catalytic functions for hydrogenation of polyaromatic hydrocarbons, for cleavage of C-C bonds in polycyclic systems such as 4-(1-naphthylmethyl)bibenzyl, for hydrogenolysis of C-O bond such as that in dinaphthylether, for hydrodeoxygenation of phenolic compounds and other oxygen-containing compounds such as xanthene, and for hydrodesulfurization of polycyclic sulfur compounds such as dibenzothiophene. The novel bimetallic and monometallic precursors synthesized and tested in this project include various Mo- and Fe-based compounds.

  10. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells (United States)

    Unahabhokha, Thitita; Chanvorachote, Pithi; Kitsongsermthon, Jutarat


    Lung cancer remains a leading public health problem as evidenced by its increasing death rate. The main cause of death in lung cancer patients is cancer metastasis. The metastatic behavior of lung cancer cells becomes enhanced when cancer cells undergo epithelial to mesenchymal transition (EMT). Gigantol, a bibenzyl compound extracted from the Thai orchid, Dendrobium draconis, has been shown to have promising therapeutic potential against cancer cells, which leads to the hypothesis that gigantol may be able to inhibit the fundamental EMT process in cancer cells. This study has demonstrated for the first time that gigantol possesses the ability to suppress EMT in non-small cell lung cancer H460 cells. Western blot analysis has revealed that gigantol attenuates the activity of ATP-dependent tyrosine kinase (AKT), thereby inhibiting the expression of the major EMT transcription factor, Slug, by both decreasing its transcription and increasing its degradation. The inhibitory effects of gigantol on EMT result in a decrease in the level of migration in H460 lung cancer cells. The results of this study emphasize the potential of gigantol for further development against lung cancer metastasis. PMID:27651818

  11. Bond cleavage reactions of the bridge structure in coal in the presence of hydrogen donating compounds; Suiso kyoyosei kagobutsu sonzaika deno sekitanchu no kakyo kozo no kairetsu hanno

    Energy Technology Data Exchange (ETDEWEB)

    Bando, N.; Kidena, K.; Murata, S.; Nomura, M. [Osaka University, Osaka (Japan). Faculty of Engineering


    In this paper, bond cleavage reactions are discussed in relation to the softening and solubilization of coal. Were used 9,10-dihydroanthracene (DHA) and 9,10-dihydrophenanthrene (DHP) as models of hydrogen donating compounds in coal, and bibenzyl, 1,2-diethane, benzylphenylether, and 1,5-dibenzylnaphthalene were used as models of bridge structure compounds. They were compared mutually, as to reactivity of coal against DHA and DHP. For the homolytic cleavage of bridges, DHA with excellent radical supplement performance provided excellent hydrogen donating performance. While, for the ipso-position cleavage of bridges, it was found that DHP can act as an effective hydrogen donor. For the reaction between coal and hydrogenated aromatic compounds, cleavage of relatively weak bonds, such as ether linkage and dimethylene linkage, occurred at about 380{degree}C, and hydrogen from DHA or DHP was consumed. On the other hand, the results suggested that the cleavage reaction at ipso-position affected by hydrogen donating solvent is also important at temperature range around 420{degree}C. 2 refs., 3 figs., 1 tab.

  12. Advances in Studies on Chemical Constituents and Antimicrobial Activity of Bryophytes%苔藓植物化学成分及抑菌作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    余治锦; 姜山


    苔藓植物是没有维管束的陆生植物,分为藓纲、苔纲和角苔纲3类。近年来的研究表明,苔藓植物能产生萜类、黄酮类及联苄类等生物活性物质,其中许多对病原真菌和细菌具有良好的抑制作用,是天然抗菌药物的重要来源。本文主要介绍苔藓植物的化学组成及其抑菌作用的研究情况。%Including Musci, Hepaticae and Anthocerotae, bryophytes are members of the land plants without vascular. Bryophytes can produce a great variety of bioactive compounds such as terpenoids, flavonoids and bibenzyls, some of which have obviously antifungal and antibacterial activities and are vital sources of naturally antimicrobial drugs. Chemical constituents of bryophyte and its antimicrobial activity are summarized and discussed in this paper.

  13. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans.

    Directory of Open Access Journals (Sweden)

    Li Zhang

    Full Text Available The yeast-to-hypha transition plays a crucial role in the pathogenesis of C. albicans. Farnesol, a quorum sensing molecule (QSM secreted by the fungal itself, could prevent the formation of hyphae and subsequently lead to the defect of biofilm formation. The DPP3, encoding phosphatase, is a key gene in regulating farnesol synthesis. In this study, we screened 24 bisbibenzyls and 2 bibenzyls that were isolated from bryophytes or chemically synthesized by using CLSI method for antifungal effect. Seven bisbibenzyls were found to have antifungal effects with IC(80 less than 32 µg/ml, and among them, plagiochin F, isoriccardin C and BS-34 were found to inhibit the hyphae and biofilm formation of C. albicans in a dose-dependent manner. To uncover the underlying relationship between morphogenesis switch and QSM formation, we measured the farnesol production by HPLC-MS and quantified Dpp3 expression by detecting the fluorescent intensity of green fluorescent protein tagged strain using Confocal Laser Scanning microscopy and Multifunction Microplate Reader. The DPP3 transcripts were determined by real-time PCR. The data indicated that the bisbibenzyls exerted antifungal effects through stimulating the synthesis of farnesol via upregulation of Dpp3, suggesting a potential antifungal application of bisbibenzyls. In addition, our assay provides a novel, visual and convenient method to measure active compounds against morphogenesis switch.

  14. Therapeutic potential of bryophytes and derived compounds against cancer

    Institute of Scientific and Technical Information of China (English)

    Abhijit Dey; Anuradha Mukherjee


    Bryophytes, taxonomically placed between the algae and the pteridophytes, are divided into three classes such as Liverworts, Hornworts and Mosses. Indigenous use involves this small group of plants to treat various diseases. Bryophytes have been investigated pharmacologically for active biomolecules. Several constituents with therapeutic potential have been isolated, characterized and investigated for antibacterial, antifungal, antiviral, antioxidative, antiinflamatory and anticancerous efficacy. The present review deals with the literature covering the anticancerous potential of bryophytes. Apart from the examples of the compounds and the containing bryophyte genera, the authors have tried to include the examples of cancer cell lines on which the efficacy have been tested and the mode of action of certain cytotoxic agents. Crude extracts and isolated compounds from bryophytes were found to possess potent cytotoxic properties. Different types of terpenoids and bibenzyls have been reported among the most potent cytotoxic compounds. Most of these compounds were found to induce apoptosis by activating a number of genes and enzymes. Biochemical markers such as DNA fragmentation, nuclear condensation, proteolysis of poly (ADP-ribose) polymerase, activation of caspases, inhibition of antiapoptotic nuclear transcriptional factor-kappaB, activation of p38 mitogen-activated protein kinase etc. have been found to be associated with apoptotic and necrotic response. This review summarizes recent scientific findings and suggests further investigations to evaluate the cytotoxic efficacy of bryophytes.

  15. Superacid Catalyzed Coal Conversion Chemistry. 1st and 2nd Quarterly Technical Progress Reports, September 1, 1983-March 30, 1984. (United States)

    Olah, G. A.


    In our laboratories we have previously developed a mild coal conversion process. This involves the use of a superacid system consisting of HF and BF{sub 3} in presence of hydrogen and/or a hydrogen donor solvent. In order to understand the chemistry involved in the process of depolymerization of coal by the HF:BF{sub 3}:H{sub 2} system we are carrying out a systematic study of a number of coal model compounds. The model compounds selected for present study have two benzene rings connected with various bridging units such as alkylidene, ether, sulfide etc. From studies so far carried out it appears that high pyridine extractibilities achieved by treating coal at temperature below 100 degrees C results from the cleavage of bridges such as present in bibenzyl, diphenyl methane, dibenzyl ether, dibenzyl sulfide etc. On the other hand the increased cyclohexane extractibility and distillability observed at relatively higher temperatures and hydrogen pressures reflects the hydrogenation and cleavage of the aromatic backbone in coal structure similar to what is seen in the conversion of model compounds such as biphenyl, diphenyl ether, diphenyl sulfide, anthracene, etc.

  16. Toward Direct Reaction-in-Flight Measurements (United States)

    Wilhelmy, Jerry; Bredeweg, Todd; Fowler, Malcolm; Gooden, Matthew; Hayes, Anna; Rusev, Gencho; Caggiano, Joseph; Hatarik, Robert; Henry, Eugene; Tonchev, Anton; Yeaman, Charles; Bhike, Megha; Krishichayan, Krishi; Tornow, Werner


    At the National Ignition Facility (NIF) neutrons having energies greater than the equilibrium 14.1 MeV value can be produced via Reaction-in-Flight (RIF) interactions between plasma atoms and upscattered D or T ions. The yield and spectrum of these RIF produced neutrons carry information on the plasma properties as well as information on the stopping power of ions under plasma conditions. At NIF the yield of these RIF neutrons is predicted to be 4-7 orders of magnitude below the peak 14 MeV neutron yield. The current generation of neutron time of flight (nTOF) instrumentation has so far been incapable of detecting these low-yield neutrons primarily due to high photon backgrounds. To date, information on RIF neutrons has been obtained in integral activation experiments using reactions with high energy thresholds such as 169Tm(n,3n)167Tm and 209Bi(n,4n) 206Bi. Initial experiments to selectively suppress photon backgrounds have been performed at TUNL using pulsed monoenergetic neutron beams of 14.9, 18.5, 24.2, and 28.5 MeV impinging on a Bibenzyl scintillator. By placing 5 cm of Pb before the scintillator we were able to selectively suppress the photons from the flash occurring at the production target and enhance the n/_signal by ~6 times.

  17. Molecular evolution and sequence divergence of plant chalcone synthase and chalcone synthase-Like genes. (United States)

    Han, Yingying; Zhao, Wenwen; Wang, Zhicui; Zhu, Jingying; Liu, Qisong


    Plant chalcone synthase (CHS) and CHS-Like (CHSL) proteins are polyketide synthases. In this study, we evaluated the molecular evolution of this gene family using representative types of CHSL genes, including stilbene synthase (STS), 2-pyrone synthase (2-PS), bibenzyl synthase (BBS), acridone synthase (ACS), biphenyl synthase (BIS), benzalacetone synthase, coumaroyl triacetic acid synthase (CTAS), and benzophenone synthase (BPS), along with their CHS homologs from the same species of both angiosperms and gymnosperms. A cDNA-based phylogeny indicated that CHSLs had diverse evolutionary patterns. STS, ACS, and 2-PS clustered with CHSs from the same species (late diverged pattern), while CTAS, BBS, BPS, and BIS were distant from their CHS homologs (early diverged pattern). The amino-acid phylogeny suggested that CHS and CHSL proteins formed clades according to enzyme function. The CHSs and CHSLs from Polygonaceae and Arachis had unique evolutionary histories. Synonymous mutation rates were lower in late diverged CHSLs than in early diverged ones, indicating that gene duplications occurred more recently in late diverged CHSLs than in early diverged ones. Relative rate tests proved that late diverged CHSLs had unequal rates to CHSs from the same species when using fatty acid synthase, which evolved from the common ancestor with the CHS superfamily, as the outgroup, while the early diverged lineages had equal rates. This indicated that late diverged CHSLs experienced more frequent mutation than early diverged CHSLs after gene duplication, allowing obtaining new functions in relatively short period of time.

  18. 铁皮石斛有效成分与功效研究进展%Advances in the of Constituents and Pharmacological Effects of Dendrobium candidum Wall. ex. Lind.

    Institute of Scientific and Technical Information of China (English)

    廖俊杰; 李文静; 李进进; 李桂锋; 姚焕霞


    铁皮石斛是具有滋阴补益功效的名贵药材, 在治疗和日常保健中应用广泛. 本文主要对铁皮石斛多糖、 生物碱、 菲类、 联苄类、 酚酸类等有效化学成分和抗肿瘤、 提高免疫、 抗衰老、 降血糖等药理作用进行综述, 为铁皮石斛有效化学成分研究及开发药用价值的天然产物提供理论基础.%Dendrobium candidum Wall. ex. Lind. is a valuable medicinal plant and is widely used in treatment and daily health care. Chemical constituents in polysaccharides, alkaloids, phenanthrenes, bibenzyls and phenolic acids are reviewed, and pharmacological effects for improving immune functioning, anti-tumor, anti-aging and lowering blood glucose are integrated. A scientific and theoretical foundation for studying constituents and biological activities of Dendrobium candidum Wall. ex. Lind. , and for further developing medicinal value of natural products is provided.

  19. The synthesis and characterization of iron colloid catalysts in inverse micelle solutions

    Energy Technology Data Exchange (ETDEWEB)

    Martino, Anthony; Sault, Allen G.; Kawola, Jeffrey S. [Fuel Science Department, Sandia National Laboratories Albuquerque, NM (United States); Stoker, Matthew; Hicks, Michael; Bartholomew, Calvin H. [Department of Chemical Engineering, Brigham Young University Provo, UT (United States)


    We have studied the synthesis and characterization of Fe based nanometer sized clusters formed in inverse micelle solutions. Inverse micelles provide a colloidal sized reaction template in an oleic solvent. Metal salts are solubilized within the interior of inverse micelles, and the addition of a reducing agent initiates nucleation and growth to produce the clusters. Surfactant acts to stabilize the particles. TEM shows that the average particle size is less than 3nm in diameter. The reduction reaction of iron salts with LiBH{sub 4} in inverse micelle solutions results in the formation of FeB, Fe{sup 2+}BO{sub x} (i.e. pyroborate), and {alpha}-Fe as determined by Mossbauer spectroscopy, electron diffraction, and X-ray photoelectron spectroscopy (XPS). Oxidation after exposure to air leads to the conversion of the FeB to {alpha}-Fe then to an undetermined Fe{sup 2+} phase and then finally to Fe{sub 3}O{sub 4}. Iron based metals are of interest as active, selective catalysts for a number of hydrogenation reactions including methanation and Fischer-Tropsch synthesis. We report catalytic results of iron clusters in the hydrogenolysis of naphthyl bibenzyl methane (NBM), a model reaction for coal liquefaction. The role of surfactant in the reaction mechanism is determined

  20. Novel bimetallic dispersed catalysts for temperature-programmed coal liquefaction

    Energy Technology Data Exchange (ETDEWEB)

    Chunshan, Song; Kirby, S.; Schmidt, E. [Pennsylvania State Univ., University Park, PA (United States)] [and others


    The objective of this project is to explore bimetallic dispersed catalysts for more efficient coal liquefaction. Coal liquefaction involves cleavage of methylene, dimethylene and ether bridges connecting various aromatic units and the reactions of various oxygen functional groups. This paper describes recent results on (1) hydrodeoxygenation of O-containing polycyclic model compounds using novel organometallic catalyst precursors; and (2) activity and selectivity of dispersed Fe catalysts from organometallic and inorganic precursors for hydrocracking of 4-(1-naphthylmethyl) bibenzyl. The results showed that some iron containing catalysts have higher activity in the sulfur-free form, contrary to conventional wisdom. Adding sulfur to Fe precursors with Cp-ligands decreased the activity of the resulting catalyst. This is in distinct contrast to the cases with iron pentacarbonyl and superfine Fe{sub 2}O{sub 3}, where S addition increased their catalytic activity substantially. A positive correlation between sulfur addition and increased activity can be seen, but a reversed trend between Fe cluster size and hydrocracking conversion could be observed, for carbonyl-type Fe precursors. It is apparent that the activity and selectivity of Fe catalysts for NMBB conversion depends strongly on both the type of ligand environment, the oxidation state and the number of intermetal bonds in the molecular precursor.

  1. Synthesis and characterization of Fe colloid catalysts in inverse micelle solutions

    Energy Technology Data Exchange (ETDEWEB)

    Martino, A.; Stoker, M.; Hicks, M. [Sandia National Lab., Alburquerque, NM (United States)] [and others


    Surfactant molecules, possessing a hydrophilic head group and a hydrophobic tail group, aggregate in various solvents to form structured solutions. In two component mixtures of surfactant and organic solvents (e.g., toluene and alkanes), surfactants aggregate to form inverse micelles. Here, the hydrophilic head groups shield themselves by forming a polar core, and the hydrophobic tails groups are free to move about in the surrounding oleic phase. The formation of Fe clusters in inverse miscelles was studied.Iron salts are solubilized within the polar interior of inverse micelles, and the addition of the reducing agent LiBH{sub 4} initiates a chemical reduction to produce monodisperse, nanometer sized Fe based particles. The reaction sequence is sustained by material exchange between inverse micelles. The surfactant interface provides a spatial constraint on the reaction volume, and reactions carried out in these micro-heterogeneous solutions produce colloidal sized particles (10-100{Angstrom}) stabilized in solution against flocculation of surfactant. The clusters were stabilized with respect to size with transmission electron microscopy (TEM) and with respect to chemical composition with Mossbauer spectroscopy, electron diffraction, and x-ray photoelectron spectroscopy (XPS). In addition, these iron based clusters were tested for catalytic activity in a model hydrogenolysis reaction. The hydrogenolysis of naphthyl bibenzyl methane was used as a model for coal pyrolysis.

  2. 构树叶中的细胞毒成分%Cytotoxic constituents from the leaves of Broussonetia papyrifera

    Institute of Scientific and Technical Information of China (English)

    冉小库; 王晓彤; 刘培培; 迟玉新; 王博佳; 窦德强; 康廷国; 熊伟


    目的:研究构树叶的化学成分.方法:采用D101型大孔吸附树脂、硅胶、ODS和半制备型高效液相色谱等分离方法对构树叶提取物分离纯化,通过1D,2D NMR技术确定其结构,并采用MTT法对分得化合物进行细胞毒活性测定,同时比色法和采用高效液相色谱法建立了对构树叶中总黄酮和cosmosiin的含量测定方法.结果:分离鉴定了6个化合物,它们的结构鉴定为:(+)-pinoresinol-4'-O-β-D-glucopyransyl-4”-O-β-D-apiofuranoside (1),cosmosiin (2),luteolin-7-O-β-D-glucopyranoside (3),liriodendrin(4),3,5,4'-trihydroxy-bibenzyl-3-O-β-D-glucoside (5),apigenin-6-C-β-D-glycopyranside (6).结论:化合物1为一个新的木脂素,化合物5,6为首次从该属植物中分离,化合物1,4,6对HepG-2细胞株有不同程度的抑制活性,而化合物2,3,5对HepG-2细胞株没有活性;根据含量测定结果得知,确定构树叶的最佳采收时间为9月份.%AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera.METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101,silica gel,and ODS column chromatography and preparative HPLC.Their structures were elucidated on the basis of 1D and 2D NMR analyses.In addition,their cytotoxic activity against human hepatoma carcinoma cells (HepG-2) were evaluated by the MTT method.Furthermore,RP-HPLC and colorimetric methods were used for the analysis of cosmosiin and total flavonoids.RESULTS:A new lignan,together with five known compounds were obtained,and their structures were characterized as (+)-pinoresinol-4'-O-β-D-glucopyranosyl-4"-O-β-D-apiofuranoside (1),cosmosiin (2),luteolin-7-O-β-D-glucopyranoside (3),liriodendrin (4),3,5,4'-trihydroxy-bibenzyl-3-O-β-D-glucoside (5),and apigenin-6-C-β-Dglucopyranside (6).Furthermore,RP-HPLC and colorimetric methods were established for the analysis of cosmosiin and total flavonoids.CONCLUSION:Compound 1 was a new lignan

  3. 构树叶中的细胞毒成分(英文)

    Institute of Scientific and Technical Information of China (English)

    冉小库; 王晓彤; 刘培培; 迟玉新; 王博佳; 窦德强; 康廷国; 熊伟



  4. Kinetics assisted design of catalysts for coal liquefaction. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Klein, M.T.; Foley, H.C.; Calkins, W.H.; Scouten, C.


    The thermal and catalytic reactions of 4-(1-naphthylmethyl)bibenzyl (NBBM), a resid and coal model compound, were examined. Catalytic reaction of NBBM was carried out at 400 C under hydrogen with a series of transition metal-based catalytic materials including Fe(CO){sub 4}PPh{sub 3}, Fe(CO){sub 3}(PPh{sub 3}){sub 2}, Fe(CO){sub 2}(PPh{sub 3}){sub 2}CS{sub 2}, Fe(CO){sub 5}, Mo(CO){sub 6}, Mn{sub 2}(CO){sub 10}, Fe{sub 2}O{sub 3} and MoS{sub 2}. Experimental findings and derived mechanistic insights were organized into molecular-level reaction models for NBBM pyrolysis and catalysis. Hydropyrolysis and catalysis reaction families occurring during NBBM hydropyrolysis at 420 C were summarized in the form of reaction matrices which, upon exhaustive application to the components of the reacting system, yielded the mechanistic reaction model. Each reaction family also had an associated linear free energy relationship (LFER) which provided an estimate of the rate constant k{sub i} given a structural property of species i or its reaction. Including the catalytic reaction matrices with those for the pyrolysis model provided a comprehensive NBBM catalytic reaction model and allowed regression of fundamental LFER parameters for the catalytic reaction families. The model also allowed specification of the property of an optimal catalyst. Iron, molybdenum and palladium were predicted to be most effective for model compound consumption. Due to the low costs associated with iron and its disposal, it is a good choice for coal liquefaction catalysis and the challenge remains to synthesize small particles able to access the full surface area of the coal macromolecule.


    Energy Technology Data Exchange (ETDEWEB)



    Inadequacies of current recovery and disposal methods for mixed plastic wastes drive the exploration of viable strategies for plastics resource recovery. The combination of diminishing landfill space and increasing usage of plastic products poses a significant dilemma, since current recovery methods are costly and ill-suited to handle contaminants. Coprocessing of polymeric waste with other materials may provide potential solutions to the deficiencies of current resource recovery methods, including unfavorable process economics. By incorporating plastic waste as a minor feed into an existing process, variations in supply and composition could be mediated, permitting continuous operation. One attractive option is the coprocessing of polymeric waste with coal under direct liquefaction conditions, allowing for simultaneous conversion of both feedstocks into high-valued products. Catalyst-directed coliquefaction of coal and polymeric materials not only has attractive environmental implications but also has the potential to enhance the economic viability of traditional liquefaction processes. By exploiting the higher H/C ratio of the polymeric material and using it as a hydrogen source, the overall process demand for molecular hydrogen and hydrogen donor solvents may be reduced. A series of model compound experiments has been conducted, providing a starting point for unraveling the complex chemistry underlying coliquefaction of coal and polymeric materials. Tetradecane (C{sub 14} H{sub 30} ) was used as a polyethylene mimic, and 4-(naphthylmethyl)bibenzyl (NBBM) was used as a coal model compound. Neat and binary mixture reactions of tetradecane and NBBM were carried out in an inert atmosphere at both low and high pressures to establish a thermal baseline for subsequent catalytic experiments. Work in the past six months has focused on analysis of light gaseous products for neat reactions of tetradecane, resulting in mass balances greater than 94%. The experimental

  6. Advances in the of Resources, Constituents and Pharmacological Effects of Dendrobium officinale%铁皮石斛资源、化学成分及药理作用研究进展

    Institute of Scientific and Technical Information of China (English)

    李娟; 李顺祥; 黄丹; 赵兴兵; 蔡光先


    Dendrobium officinale is a valuable medicinal plant, and is widely used in the treatment and daily health care, however, the lack of wild resources and expensive price lead to market disruption of Dendrobium officinale With the maturation of artificial cultivation technology, the problem related to the lack of resources is gradually solved in recent years. Its tissue culture, cultivation, quality control, chemical constituents, pharmacology and clinical applications, etc are studied at home and aboard. Resources of Dendrobium officinal*: in terra of the Latin name, morphological characteristics, commodity, quality evaluation, and genetic diversity are comprehensively summarized, chemical constituents in polysaccharides, ami no acids, trace elements, phenanthrenes, bibenzyls, phenolic acids, and alkaloids are reviewed, and pharmacological effects for improving immune functioning, anti-tumor, anti -aging, lowering blood glucose and blood pressure are integrated. A scientific and theoretical foundation for studying constituents and biological activities of Dendrobium officinale, and for further developing medicinal value of natural products is provided.%铁皮石斛是滋阴补益的名贵药用植物,在治疗和日常保健中应用广泛.由于野生资源的匮乏和价格昂贵等原因,导致市场上的铁皮石斛良莠不齐,掺假严重.随着人工栽培技术的日益成熟,铁皮石斛资源匮乏的问题逐步得到解决.近10年,国内外对其组织培养、种植栽培、鉴别和质量控制、化学成分、药理作用和临床应用等方面进行了大量深入研究.本文主要从铁皮石斛拉丁学名、商品、资源现状、质量评价和遗传多样性等方面综述铁皮石斛的资源情况;对已发现的多糖、氨基酸、微量元素、菲类、联苄类、酚酸类和生物碱等类型的化学成分和提高免疫、抗肿瘤、抗衰老、降血糖和降血压等药理作用进行系统综述,为铁皮石斛化学成分与

  7. Progress in the studies on chemical constituents and anti-tumor effects of polytrichum spp%金发藓属化学成分及抗肿瘤作用研究进展

    Institute of Scientific and Technical Information of China (English)

    成晓霞; 张志琪; 肖娅萍; 刘全宏


    The recent advances in the study on chemical constituents,pharmacological activities and anti-tumor mechanism of Polytrichum spp.are reviewed.A series of new compounds with novel skeletons and significant bioactivities have been obtained from Polytrichum spp. For example,1 1 new benzonaphthoxanthenones with novel polycyclic skeleton,2 unusual flavonones coupled with styryl units and 2 novel cinnamoyl bibenzyls from the moss Polytrichum commune L.ex Hedw, Polytrichum ohioense Ren&Card and Polytrichum pallidisetum Funck, respectively.These compounds exhibited cytotoxicity against several kinds of tumor cells in vitro,including human lung carcinoma (A-549),human hepatoma carcinoma (HepG2),human breast adenocarcinoma (MCF-7 & MDA-MB-435),huamn bowel carcinoma (LOVO),human colon adenocarcinoma (HT-29 ), Human melanoma (RPMI-7951 ) and human glioblastoma multiforme (U-251).Moreover,these new compounds also can significantly inhibit the growth of leukaemia cells (6T-CEM human T cell leukemia,9PS murine P388 leukemia and L1210 murine lymphocytic leukemia ). Studies demonstrated that mitochondria dysfunction, excessive accumulation of active oxygen radicals,cell cycle arrest,cell membrane inj ury and cell apoptosis-inducing are the possible underlying anti-tumor mechanisms. Further studies are needed to confirm the chemical structure-antitumor activity relationship, drug metabolism, anti-tumor effects and precise mechanism not only in vitro but in vivo.%从金发藓的化学成分、抗肿瘤活性和抑癌机制等方面对国内外金发藓属植物研究的现状进行了综述.已有研究表明,在金发藓属(Polytrichum spp.)植物中分离得到苯并萘并呫吨酮类化合物及其衍生物、苯乙烯醛基并联苄化合物和苯乙烯基并二氢黄酮类化合物等具有新颖结构骨架的化合物,药理活性分析显示这些新化合物对体外培养的多种肿瘤细胞(如:A-549人肺癌细胞、HepG2人肝癌细胞、MCF-7人乳腺