WorldWideScience

Sample records for bia approve lenders

  1. 25 CFR 103.11 - How does BIA approve lenders for the Program?

    Science.gov (United States)

    2010-04-01

    ... opportunities the lender has given to Indian business efforts through the Program; and (5) The lender's... corporate structure; (2) The effective date of a merger between the lender and any other entity, when the... of the lender's assets may be subject to disposition through laws governing bankruptcy, insolvency...

  2. 25 CFR 103.39 - When will BIA refuse to pay all or part of a lender's claim?

    Science.gov (United States)

    2010-04-01

    ... to liquidate loan collateral, and: (1) The lender has not made a reasonable effort to liquidate all... from collateral liquidation proceeds applied to the loan balance; or (e) The lender has otherwise... ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY Default and Payment by BIA § 103.39 When will BIA...

  3. 75 FR 28814 - FHA Lender Approval, Annual Renewal, Periodic Updates and Required Reports From FHA Approved Lenders

    Science.gov (United States)

    2010-05-24

    ... proposal. This information is required for: (1) FHA lender approval, (2) Annual renewal of each FHA lender... following information: Title of Proposal: FHA Lender Approval, Annual Renewal, Periodic Updates and Required... and HUD-92001-C. Description of the Need for the Information and Its Proposed Use: This information is...

  4. 25 CFR 103.19 - When must the lender pay BIA the loan guaranty or insurance premium?

    Science.gov (United States)

    2010-04-01

    ... insurance premium? 103.19 Section 103.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY How a Lender Obtains a Loan Guaranty or Insurance Coverage § 103.19 When must the lender pay BIA the loan guaranty or insurance premium? The premium...

  5. 25 CFR 103.16 - How does BIA approve or reject a loan guaranty or insurance application?

    Science.gov (United States)

    2010-04-01

    ..., or if necessary, from liquidating loan collateral. Lenders are expected to obtain a first lien security interest in enough collateral to reasonably secure repayment of each loan guaranteed or insured... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA approve or reject a loan guaranty or...

  6. 75 FR 12251 - Notice of Proposed Information Collection for Public Comment; FHA Lender Approval, Annual Renewal...

    Science.gov (United States)

    2010-03-15

    ... Lenders. OMB Control Number, if applicable: 2502-0005. Description of the need for the information and proposed use: The information is used by FHA to verify that lenders meet all approval, renewal, update and... Information Collection for Public Comment; FHA Lender Approval, Annual Renewal, Periodic Updates and...

  7. 78 FR 17937 - Notice of Proposed Information Collection for Public Comment; FHA Lender Approval, Annual Renewal...

    Science.gov (United States)

    2013-03-25

    ... Lenders. OMB Control Number, if applicable: 2502-0005. Description of the need for the information and proposed use: The information is used by FHA to verify that lenders meet all approval, renewal, update and... Information Collection for Public Comment; FHA Lender Approval, Annual Renewal, Periodic Updates and...

  8. 78 FR 36560 - 30-Day Notice of Proposed Information Collection: FHA Lender Approval, Annual Renewal, Periodic...

    Science.gov (United States)

    2013-06-18

    ... 92001-C Non-compliances on Title I Lenders Description of the need for the information and proposed use... Information Collection: FHA Lender Approval, Annual Renewal, Periodic Updates and Noncompliance Reporting by FHA Approved Lenders AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY...

  9. 77 FR 63323 - Notice of Proposed Information Collection for Public Comment; FHA Lender Approval, Annual Renewal...

    Science.gov (United States)

    2012-10-16

    ... Lenders OMB Control Number, if applicable: 2502-0005. Description of the need for the information and proposed use: The information is used by FHA to verify that lenders meet all approval, renewal, update and... Information Collection for Public Comment; FHA Lender Approval, Annual Renewal, Periodic Updates and...

  10. 76 FR 34091 - Notice of Proposed Information Collection for Public Comment; FHA Lender Approval, Annual Renewal...

    Science.gov (United States)

    2011-06-10

    ... managing its financial risks and protect consumers from lender noncompliance with FHA rules and regulations... Information Collection for Public Comment; FHA Lender Approval, Annual Renewal, Periodic Updates and Noncompliance Reporting by FHA Approved Lenders AGENCY: Office of the Assistant Secretary for Housing, HUD...

  11. 25 CFR 103.32 - What sort of loan documentation does BIA expect the lender to maintain?

    Science.gov (United States)

    2010-04-01

    ... other documentation of efforts to liquidate loan collateral; and (i) Originals or copies, as appropriate... 25 Indians 1 2010-04-01 2010-04-01 false What sort of loan documentation does BIA expect the... FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY Loan Servicing Requirements § 103.32...

  12. 24 CFR 202.9 - Investing lenders and mortgagees.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Investing lenders and mortgagees... Investing lenders and mortgagees. (a) Definition. An investing lender or mortgagee is an organization that is not approved under any other section of this part. An investing lender or mortgagee may purchase...

  13. 25 CFR 103.14 - Can BIA request additional information?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA request additional information? 103.14 Section 103.14 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY How a Lender Obtains a Loan Guaranty or Insurance Coverage § 103.14 Can BIA...

  14. 49 CFR 22.27 - Eligible reimbursements to participating lenders.

    Science.gov (United States)

    2010-10-01

    ... reimbursement. Prior written approval from DOT OSDBU is required. Attorney fees will be reimbursed on a pro-rata... 49 Transportation 1 2010-10-01 2010-10-01 false Eligible reimbursements to participating lenders... PROGRAM (STLP) Participating Lenders § 22.27 Eligible reimbursements to participating lenders...

  15. Mortgage lenders and loans

    NARCIS (Netherlands)

    Aalbers, M.B.; Smith, S.J.

    2012-01-01

    This article presents a short historical overview of the different types of lenders that are active in the origination of residential mortgage loans. First, a distinction is made between depository and nondepository lenders. Second, there are two major types of depository lenders: commercial banks,

  16. 77 FR 21991 - Federal Housing Administration (FHA): Multifamily Accelerated Processing (MAP)-Lender and...

    Science.gov (United States)

    2012-04-12

    .... This practice would mitigate risk, since MAP lenders and underwriters will now be approved at a tier... Administration (FHA): Multifamily Accelerated Processing (MAP)--Lender and Underwriter Eligibility Criteria and Credit Watch for MAP Lenders AGENCY: Office of the Assistant Secretary for Housing--Federal Housing...

  17. 25 CFR 103.37 - What must the lender do to collect payment under its loan guaranty certificate or loan insurance...

    Science.gov (United States)

    2010-04-01

    ... collateral securing the loan under § 103.36(d)(2), and has a residual loss after doing so, it must send BIA... principal collateral securing the loan; or (iii) One hundred eighty calendar days after the date of the default. (b) For insured loans, after liquidating all loan collateral, the lender must submit a claim for...

  18. HUD Subprime and Manufactured Home Lender List

    Data.gov (United States)

    Department of Housing and Urban Development — The U.S. Department of Housing and Urban Development (HUD) periodically produce its HUD Subprime and Manufactured home Lender List for the lenders who specialize in...

  19. The French National Authority for Health (HAS) Guidelines for Conducting Budget Impact Analyses (BIA).

    Science.gov (United States)

    Ghabri, Salah; Autin, Erwan; Poullié, Anne-Isabelle; Josselin, Jean Michel

    2018-04-01

    Budget impact analysis (BIA) provides short- and medium-term estimates on changes in budgets and health outcomes resulting from the adoption of new health interventions. The purpose of this study is to present the newly developed French National Authority for Health (HAS) guidelines on budget impact analysis as follows: process, literature review, recommendations and comparisons with other guidelines. The development process of the HAS guidelines included a literature review (search dates: January 2000 to June 2016), a retrospective investigation of BIA previously submitted to HAS, a public consultation, international expert reviews and approval from the HAS Board and the Economic and Public Health Evaluation Committee of HAS. Documents identified in the literature review included 12 national guidelines, 5 recommendations for good practices developed by national and international society of health economics and 14 methodological publications including recommendations for conducting BIA. Based on its research findings, HAS developed its first BIA guidelines, which include recommendations on the following topics: BIA definition, perspective, populations, time horizon, compared scenarios, budget impact models, costing, discounting, choice of clinical data, reporting of results and uncertainty exploration. It is expected that the HAS BIA guidelines will enhance the usefulness, quality and transparency of BIA submitted by drug manufacturers to HAS. BIA is becoming an essential part of a comprehensive economic assessment of healthcare interventions in France, which also includes cost-effectiveness analysis and equity of access to healthcare.

  20. 7 CFR 3565.110 - Insolvency of lender.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Insolvency of lender. 3565.110 Section 3565.110... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Lender Requirements § 3565.110 Insolvency of lender. The... determination of insolvency by the lender. If the lender fails to transfer a loan when required, the guarantee...

  1. 13 CFR 120.410 - Requirements for all participating Lenders.

    Science.gov (United States)

    2010-01-01

    ... performance, as determined by SBA in its discretion. The 7(a) Lender's Risk Rating, among other factors, will... Lenders. 120.410 Section 120.410 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Participation Criteria § 120.410 Requirements for all participating Lenders. A Lender must...

  2. 12 CFR 619.9135 - Direct lender.

    Science.gov (United States)

    2010-01-01

    ... and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9135 Direct lender. The term direct lender refers to Farm Credit banks and associations (production credit associations, agricultural credit associations, and Federal land credit associations) authorized to lend to eligible...

  3. How SEA can inform lenders

    DEFF Research Database (Denmark)

    Banhalmi-Zakar, Zsuzsa; Larsen, Sanne Vammen

    with identifying the financial incentives that ‘green’ projects attract. Although bank lending decisions apply to projects, examination of the lending practices of an Australian and a Hungarian bank have shown that decisions about the type of projects to target or avoid are also made at strategic level...... to inform bank lending decisions.......SEA can be a powerful tool to improve decision-making for plans, policies and programmes, but it can also be a useful for banks. SEA can help lenders address the reputational risks they are exposed to through financing projects that may have a negative impact on the environment and it can also help...

  4. 13 CFR 120.1000 - Risk-Based Lender Oversight.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Risk-Based Lender Oversight. 120.1000 Section 120.1000 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1000 Risk-Based Lender Oversight. (a) Risk-Based Lender...

  5. 13 CFR 500.211 - Lender responsibilities.

    Science.gov (United States)

    2010-01-01

    ...) Monitoring. In accordance with the Guarantee the Lender shall monitor Borrower's performance under the Loan... borrower, as provided in the Guarantee; (2) Projected balance sheet, income statement, and cash flows for...

  6. 13 CFR 120.441 - How does a Lender become a CLP Lender?

    Science.gov (United States)

    2010-01-01

    ... consider whether the Lender: (1) Has the ability to process, close, service and liquidate loans; (2) Has a... application packages; (3) Has an acceptable SBA purchase rate; and (4) Has shown the ability to work well with... Lender may appeal to the D/FA, whose decision will be final. If SBA grants CLP status, it applies only in...

  7. 7 CFR 1980.309 - Lender participation in guaranteed RH loans.

    Science.gov (United States)

    2010-01-01

    ...) Has any change in the Lender name, location, address, or corporate structure; (F) Has become... interests of the Lender and the Government. If the Lender is determined to be no longer eligible, the Lender...

  8. 24 CFR 232.865 - Election by lender.

    Science.gov (United States)

    2010-04-01

    ... FACILITIES Contract Rights and Obligations Rights and Duties of Lender Under the Contract of Insurance § 232.865 Election by lender. Where a real estate mortgage, or other security instrument has been used to...

  9. 24 CFR 241.865 - Election by the lender.

    Science.gov (United States)

    2010-04-01

    ... Without a HUD-Insured or HUD-Held Mortgage Rights and Duties of Lender Under the Contract of Insurance § 241.865 Election by the lender. Where a real estate mortgage, or other security instrument has been...

  10. 12 CFR 528.5 - Equal Housing Lender Poster.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Equal Housing Lender Poster. 528.5 Section 528... REQUIREMENTS § 528.5 Equal Housing Lender Poster. (a) Each savings association shall post and maintain one or more Equal Housing Lender Posters, the text of which is prescribed in paragraph (b) of this section, in...

  11. 12 CFR 626.6025 - Equal housing lender poster.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Equal housing lender poster. 626.6025 Section... § 626.6025 Equal housing lender poster. (a) Each Farm Credit institution that makes loans for the... by a dwelling shall post and maintain an Equal Housing Lender Poster in the lobby of each of its...

  12. 7 CFR 762.106 - Preferred and certified lender programs.

    Science.gov (United States)

    2010-01-01

    ... eligible lender under § 762.105; (2) Have a lender loss rate not in excess of the maximum CLP loss rate... loss rate criteria for those lenders whose loss rate was substantially affected by a disaster as... number of guaranteed OL, FO, or Soil and Water (SW) loans established by the Agency and published...

  13. 7 CFR 762.105 - Eligibility and substitution of lenders.

    Science.gov (United States)

    2010-01-01

    ... from participation in Government contracts or programs or be delinquent on a Government debt. (c... writing by executing a modification of the guarantee to identify the new lender, the amount of debt at the... the loan. (d) Lender name or ownership changes. (1) When a lender begins doing business under a new...

  14. 13 CFR 500.201 - Eligible Lender.

    Science.gov (United States)

    2010-01-01

    ...: (1) The Lender's level of regulatory capital, in the case of banking institutions, or net worth, in... eligible to apply to the Board for a Guarantee of a loan must be: (1) A banking institution, such as a commercial bank or trust company, subject to regulation by the Federal banking agencies enumerated in 12 U.S...

  15. 7 CFR 2201.13 - Lender.

    Science.gov (United States)

    2010-01-01

    ... guaranteed loans; (4) The performance of the Lender's loan portfolio, including its current delinquency rate... nationally recognized statistical rating organization, as evidenced by written confirmation from the nationally recognized statistical rating organization, subject to updating upon request of the Board; and (ii...

  16. 7 CFR 4279.29 - Eligible lenders.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL... have the legal authority to operate a lending program and sufficient lending expertise and financial... consideration to become a guaranteed lender must submit a request in writing to the State Office for the State...

  17. Discharge of residual debt: Do private and institutional lenders differ?

    OpenAIRE

    Kirchkamp, Oliver; Prömpers, Henning

    2013-01-01

    With the help of lab experiments we study the impact of discharging insolvent debtors of their residual debt. We investigate the impact of different participation rules and the impact of different types of lenders. We find that higher participation rates encourage risk taking behaviour of borrowers. Higher participation rates also reduce the amount of moonlighting. Most importantly, institutional lenders can suffer more from moonlighting than private lenders.

  18. 13 CFR 120.451 - How does a Lender become a PLP Lender?

    Science.gov (United States)

    2010-01-01

    ... for final decision. (b) In making its decision, SBA considers whether the Lender: (1) Has the required..., historical performance measures (like default rate, purchase rate and loss rate), loan volume to the extent..., policies and procedures. The recertification decision is made by the appropriate Office of Capital Access...

  19. 78 FR 55238 - Notice of Request for Extension of a Currently Approved Information Collection

    Science.gov (United States)

    2013-09-10

    ... participating lenders, the Agency keeps abreast of information required by other lenders to ensure that RHS is... Agency needs updated income and financial information to settle any outstanding indebtedness. With the... Approved Information Collection AGENCY: Rural Housing Service, USDA. ACTION: Notice and request for...

  20. 75 FR 13073 - Notice of Request for Extension of a Currently Approved Information Collection

    Science.gov (United States)

    2010-03-18

    ... participating lenders, the Agency keeps abreast of information required by other lenders to ensure that RHS is... Agency needs updated income and financial information to settle any outstanding indebtedness. With the... Approved Information Collection AGENCY: Rural Housing Service, USDA. ACTION: Notice and request for...

  1. 34 CFR 601.10 - Preferred lender arrangement disclosures.

    Science.gov (United States)

    2010-07-01

    ... Loan (FFEL) Program from any eligible lender the student selects; and (2) On such covered institution's... interest rates, or other terms and conditions or provisions of Title IV, HEA program loans or private... loyalty to compile the preferred lender list under paragraph (d) of this section without prejudice and for...

  2. 13 CFR 120.1070 - Lender oversight fees.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Lender oversight fees. 120.1070 Section 120.1070 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based... Lender” means a Small Business Lending Company or a Non-Federally Regulated Lender. (2) On-site reviews...

  3. 12 CFR 560.110 - Most favored lender usury preemption.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Most favored lender usury preemption. 560.110... INVESTMENT Lending and Investment Provisions Applicable to all Savings Associations § 560.110 Most favored... permits its most favored lender to charge late fees, then a savings association located in that state may...

  4. 7 CFR 4287.135 - Substitution of lender.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE SERVICING Servicing Business and Industry Guaranteed... borrower, the proposed substitute lender, and the original lender if still in existence. (b) Where the...

  5. 25 CFR 170.801 - What is the BIA Road Maintenance Program?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the BIA Road Maintenance Program? 170.801 Section... ROADS PROGRAM BIA Road Maintenance § 170.801 What is the BIA Road Maintenance Program? The BIA Road... subpart contains a list of activities that are eligible for funding under the BIA road maintenance program. ...

  6. Funkcje białek bakteriofagowych

    Directory of Open Access Journals (Sweden)

    Ewa Brzozowska

    2011-01-01

    Full Text Available Bakteriofagi (fagi stanowią naturalny czynnik regulujący liczebność populacji bakteryjnych w przyrodzie. Zainteresowanie bakteriofagami ciągle wzrasta ze względu na ich ogromną liczebność w naturalnym środowisku, a tym samym wpływ na funkcjonowanie organizmów żywych oraz zastosowanie w terapii przeciwko patogennym bakteriom opornym na stosowane antybiotyki. Za swoistość i za zjadliwość fagów wobec bakterii odpowiadają białka wchodzące w skład cząstki fagowej. Białkami tymi są adhezyny rozpoznające receptory na komórkach gospodarzy oraz enzymy degradujące określone struktury ściany komórkowej lub otoczki bakterii. Inne białka fagowe pełnią funkcję strukturalną, wchodząc w skład kapsydów. Białka te chronią fagowy kwas nukleinowy oraz umożliwiają przekazanie wirusowego genomu do wnętrza komórki bakteryjnej, a tym samym odpowiadają za proces infekcji i namnażania fagów potomnych. Enzymy fagowe są ważną grupą białek, które degradują struktury ścian i otoczek bakteryjnych od zewnętrznej, a także od wewnętrznej strony komórki gospodarza. Są to enzymy lityczne hydrolizujące komponenty cukrowe oraz białkowe. Bliższe poznanie natury bakteriofagów oraz pojawienie się lekooporności wśród patogennych bakterii, spowodowało wzrost zainteresowania fagami, jako czynnikami leczniczymi. Bakteriofagi coraz częściej wykorzystywane są także w innych dziedzinach życia człowieka. Testowano je nie tylko w terapii roślin, zwierząt i ludzi, ale także zaproponowano ich użycie do odkażania żywności i środowiska.

  7. 13 CFR 120.424 - What are the basic conditions a Lender must meet to securitize?

    Science.gov (United States)

    2010-01-01

    ... performance, as determined by SBA in its discretion. The Lender's Risk Rating, among other factors, will be... Lender must meet to securitize? 120.424 Section 120.424 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Lenders Participating Lender Financings § 120.424 What are the basic conditions a...

  8. 75 FR 62335 - Federal Housing Administration (FHA) Single Family Lender Insurance Process: Eligibility...

    Science.gov (United States)

    2010-10-08

    ... those lenders with ineffective risk management practices and/or those lenders who have refused to... a marginal impact on those lenders with ineffective risk management practices and who have refused... has any impact, it will be as a consequence of the lender's inability to maintain acceptable risk...

  9. 7 CFR 4279.43 - Certified Lender Program.

    Science.gov (United States)

    2010-01-01

    ... guaranteed by any Federal agency, with information on delinquencies and losses and, if applicable, the... lender will provide a written certification to this effect along with a statistical analysis of its...

  10. 25 CFR 103.6 - To what extent will BIA guarantee or insure a loan?

    Science.gov (United States)

    2010-04-01

    ... insurance percentage rate that satisfies the lender's risk management requirements. (d) Absent exceptional... lender has insured under the Program as of the date the lender makes a claim under its insurance coverage... outstanding loans from the same lender to the same borrower; or (2) One loan guaranty under the Program when...

  11. 42 CFR 60.43 - Limitation, suspension, or termination of the eligibility of a HEAL lender or holder.

    Science.gov (United States)

    2010-10-01

    ... notice, sent by certified mail, specifying his or her intention to terminate the lender or holder's... that a HEAL lender fails to meet the statutory definition of an “eligible lender.” (d) This section...

  12. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Science.gov (United States)

    2010-04-01

    ... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible for maintenance under the BIA Road Maintenance Program: (1) BIA transportation facilities listed in...

  13. 25 CFR 170.804 - How is BIA's Road Maintenance Program related to the IRR Program?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How is BIA's Road Maintenance Program related to the IRR... WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.804 How is BIA's Road Maintenance Program related to the IRR Program? The following chart illustrates how BIA's Road Maintenance Program is...

  14. 13 CFR 120.1010 - SBA access to SBA Lender, Intermediary, and NTAP files.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBA access to SBA Lender, Intermediary, and NTAP files. 120.1010 Section 120.1010 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Supervision § 120.1010 SBA access to SBA Lender...

  15. 12 CFR 617.7130 - What initial disclosures must a qualified lender make to a borrower?

    Science.gov (United States)

    2010-01-01

    ... lender make to a borrower? 617.7130 Section 617.7130 Banks and Banking FARM CREDIT ADMINISTRATION FARM... must a qualified lender make to a borrower? (a) Required disclosures—in general. A qualified lender... certificates that borrowers are required to purchase are at risk and may only be retired at the discretion of...

  16. 75 FR 13145 - SBA Lender Risk Rating System

    Science.gov (United States)

    2010-03-18

    ... SMALL BUSINESS ADMINISTRATION [Docket No. SBA-2010-0004] SBA Lender Risk Rating System AGENCY: Small Business Administration. ACTION: Notice; extension of comment period and correction. SUMMARY: On... of Credit Risk Management, U.S. Small Business Administration, 409 Third Street, SW., 8th Floor...

  17. 7 CFR 3565.304 - Lender loan processing responsibilities.

    Science.gov (United States)

    2010-01-01

    ... application at the feasibility stage or when they request a conditional commitment. (b) Project servicing, management and disposition. Unless otherwise permitted by the Agency, the originating lender must perform all loan functions during the period of the guarantee. These functions include servicing, asset management...

  18. 24 CFR 202.6 - Supervised lenders and mortgagees.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Supervised lenders and mortgagees. 202.6 Section 202.6 Housing and Urban Development Regulations Relating to Housing and Urban... Secretary in the amount of 20 percent of its net worth, up to a maximum liquidity requirement of $100,000...

  19. 13 CFR 120.1600 - General procedures for enforcement actions against SBA Lenders, SBA Supervised Lenders, Other...

    Science.gov (United States)

    2010-01-01

    ... Persons, Intermediaries, and NTAPs. 120.1600 Section 120.1600 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions § 120.1600 General... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false General procedures for enforcement...

  20. Use of electrocardiogram (ECG) electrodes for Bioelectrical Impedance Analysis (BIA)

    International Nuclear Information System (INIS)

    Caicedo-Eraso, J C; González-Correa, C H; González-Correa, C A

    2012-01-01

    BIA is a safe, noninvasive, portable and relatively inexpensive method of estimating body composition that is practical and suitable for individual use and large-scale studies. However, the cost of the electrodes recommended by some BIA manufacturers is too high for developing countries; where very often the long and complicated process of importation reduces the time they can be used. The purpose of this study was to evaluate the use of two types of ECG electrodes (2290 and 2228 by 3M ® ) in BIA measurements to decrease the costs of the test. The results showed that the 2228 ECG electrodes can be used in BIA measurements for adult's body composition assessment. These electrodes are available in the domestic market and their costs are 92% lower than the electrodes recommended by manufacturer. The results show a new cost-benefit relation for BIA method and make this a more accessible tool for individual tests, large-scale researches and studies in the community.

  1. [Abdomen specific bioelectrical impedance analysis (BIA) methods for evaluation of abdominal fat distribution].

    Science.gov (United States)

    Ida, Midori; Hirata, Masakazu; Hosoda, Kiminori; Nakao, Kazuwa

    2013-02-01

    Two novel bioelectrical impedance analysis (BIA) methods have been developed recently for evaluation of intra-abdominal fat accumulation. Both methods use electrodes that are placed on abdominal wall and allow evaluation of intra-abdominal fat area (IAFA) easily without radiation exposure. Of these, "abdominal BIA" method measures impedance distribution along abdominal anterior-posterior axis, and IAFA by BIA method(BIA-IAFA) is calculated from waist circumference and the voltage occurring at the flank. Dual BIA method measures impedance of trunk and body surface at the abdominal level and calculates BIA-IAFA from transverse and antero-posterior diameters of the abdomen and the impedance of trunk and abdominal surface. BIA-IAFA by these two BIA methods correlated well with IAFA measured by abdominal CT (CT-IAFA) with correlatipn coefficient of 0.88 (n = 91, p abdominal adiposity in clinical study and routine clinical practice of metabolic syndrome and obesity.

  2. 23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR part...

  3. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the IRR Program and BIA Road Maintenance Program... and BIA Road Maintenance Program policy? (a) It is the policy of the Secretary of the Interior and the... designed to enable Indian tribes to participate in all contractible IRR and BIA Road Maintenance programs...

  4. 25 CFR 103.12 - How does a lender apply for a loan guaranty?

    Science.gov (United States)

    2010-04-01

    ... of the lender's loan guaranty application package, outlining the credit history of the borrower, and... all makers, cosigners and guarantors, maturity dates, payment schedules, uncured delinquencies...

  5. 25 CFR 170.808 - Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA Road Maintenance Program funds be used to improve... THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.808 Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities? No. BIA Road...

  6. 75 FR 80066 - Quality Control Requirements for Direct Endorsement Lenders; Notice of Proposed Information...

    Science.gov (United States)

    2010-12-21

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5380-N-50] Quality Control Requirements... information: Title of Proposal: Quality Control Requirements for Direct Endorsement Lenders. OMB Control... a result, DE lenders will be responsible for conducting quality control on TPO originations of FHA...

  7. 24 CFR 232.520 - Maximum fees and charges by lender.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MORTGAGE INSURANCE FOR NURSING HOMES, INTERMEDIATE CARE FACILITIES, BOARD AND CARE HOMES, AND... of Fire Safety Equipment Fees and Charges § 232.520 Maximum fees and charges by lender. The lender...

  8. 12 CFR 591.4 - Loans originated by lenders other than Federal savings associations.

    Science.gov (United States)

    2010-01-01

    ... Federal savings associations. (a) With regard to any real property loan originated by a lender other than... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Loans originated by lenders other than Federal savings associations. 591.4 Section 591.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF...

  9. 12 CFR 617.7125 - How should a qualified lender determine the effective interest rate?

    Science.gov (United States)

    2010-01-01

    ... effective interest rate? 617.7125 Section 617.7125 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Disclosure of Effective Interest Rates § 617.7125 How should a qualified lender determine the effective interest rate? (a) A qualified lender must calculate the effective interest rate on...

  10. How do mortgage lenders influence neighbourhood dynamics? Redlining and predatory lending

    NARCIS (Netherlands)

    Aalbers, M.B.; van Ham, M.; Manley, D.; Bailey, N.; Simpson, L.; Maclennan, D.

    2013-01-01

    Manuel Aalbers argues that the actions of mortgage lenders can play an important role in understanding the trajectories of some of the most deprived neighbourhoods in Western cities. Mortgage lenders use the notion of the neighbourhood as a means to reduce their risk or to extract profit, and as

  11. Lender of last resort in a monetary union

    Directory of Open Access Journals (Sweden)

    Gylfi Magnússon

    2014-12-01

    Full Text Available The theory of optimal currency areas was developed during the 1960’s and 1970’s. At that time the international financial system was very different from the current system, banking systems were smaller and the flow of funds across borders limited. Developments in the Eurozone in recent years have shown that when the theory was developed and the decision made to adopt the euro some of the drawbacks of a common currency were not foreseen and important issues were not addressed. This includes the role of a common central bank as a lender of last resort to national governments. In addition, few foresaw how many closely linked financial systems could create problems that are unsolvable without the cooperation of several governments. An adequate framework for dealing with such problems was thus not put in place. The possibility that macro-economic shocks could originate in the financial system was mainly ignored. During the current crisis it has been necessary to address all these issues. It took four years to find a politically viable solution. This involves the redefinition of the role of the European Central Bank, making it a lender of last resort to national governments. This policy change buys time to deal with many fundamental imbalances within the Eurozone but does not in and of itself solve the underlying problems. The delay in implementing this policy was however very costly.

  12. Preliminary bioelectrical impedance analysis (BIA) equation for body composition assessment in young females from Colombia

    International Nuclear Information System (INIS)

    Caicedo, J C; González-Correa, C H; González-Correa, C A

    2013-01-01

    A previous study showed that reported BIA equations for body composition are not suitable for Colombian population. The purpose of this study was to develop and validate a preliminary BIA equation for body composition assessment in young females from Colombia, using hydrodensitometry as reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, BIA, residual lung volume (RV) and underwater weight (UWW) were measured. A preliminary BIA equation was developed (r 2 = 0.72, SEE = 2.48 kg) by stepwise multiple regression with fat-free mass (FFM) as dependent variable and weight, height and impedance measurements as independent variables. The quality of regression was evaluated and a cross-validation against 50% of sample confirmed that results obtained with the preliminary BIA equation is interchangeable with results obtained with hydrodensitometry (r 2 = 0.84, SEE = 2.62 kg). The preliminary BIA equation can be used for body composition assessment in young females from Colombia until a definitive equation is developed. The next step will be increasing the sample, including a second reference method, as deuterium oxide dilution (D 2 O), and using multi-frequency BIA (MF-BIA). It would also be desirable to develop equations for males and other ethnic groups in Colombia.

  13. Tekst (dźwiękowy Mirona Białoszewskiego

    Directory of Open Access Journals (Sweden)

    Andrzej Hejmej

    2007-08-01

    Full Text Available The paper focuses on the interaction between the visual text and sound-text in the works of Miron Białoszewski, especially in his Separate Theatre. In this case, considerations on the subject of textuality show a relation between Białoszewskim linguistics experiments and contemporary sound poetry. In essence, the sound poetry as an artistic practice (particularly, the sound poetry of Bernard Heidsieck appears to be an important and inspiring context for interpretation of Białoszewskim text. Finally, based on the problem of sound-text, many similarities are found between Miron Białoszewski and Bernard Heidsieck.

  14. 77 FR 51465 - Federal Housing Administration: Strengthening Risk Management Through Responsible FHA-Approved...

    Science.gov (United States)

    2012-08-24

    ... equal to ``the size standard for its industry classification established by the Small Business Administration at 13 CFR 121.201 Sector 52 (Finance and Insurance), Subsector 522 (Credit Intermediation and... approved lender or mortgagee that exceeds the size standard for its industry classification established by...

  15. 7 CFR 762.130 - Loan approval and issuing the guarantee.

    Science.gov (United States)

    2010-01-01

    ... complete until all information required to make an approval decision, including the information for an... lender's loan or line of credit conditions and requirements since submission of the application (except... compensation, and personal life insurance (when required) are in effect; (iii) Truth in lending requirements...

  16. 13 CFR 120.1500 - Types of enforcement actions-SBA Lenders.

    Science.gov (United States)

    2010-01-01

    ... general partner, a manager, an employee, an agent or other participant in the affairs of an SBA Lender's... termination. SBA may institute a civil action to terminate the rights, privileges, and franchises of an SBLC...

  17. Bioelectrical impedance analysis (BIA) equations validation against hydrodensitometry in a Colombian population

    International Nuclear Information System (INIS)

    Caicedo-Eraso, J C; Gonzalez-Correa, C A; Gonzalez-Correa, C H

    2013-01-01

    Several studies have shown that the accuracy of BIA results depends of ethnicity, age, gender, hormonal and genetic variations and, so far, there are not specific equations for Colombian population. The purpose was to evaluate reported BIA equations to determine their usefulness in body composition assessment in young females from Colombia using hydrodensitometry as the reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, multi-frequency BIA, residual lung volume (RV) and underwater weight (UWW) were measured. Five BIA equations met the inclusion criteria of this study. Three equations overestimated and two equations underestimated body fat (BF). Paired Student t-test and Bland and Altman analysis (p<0.05) showed significant differences in four BIA equations. However, all standard error of estimate (SEE) to BF was greater than 2.7 kg. This study showed that the five selected BIA equations are not valid for estimation of body composition in young females from Colombia. It is recommended to develop BIA equations to improve BF fat assessment in our population.

  18. 43 CFR 30.128 - What happens if an error in BIA's estate inventory is alleged?

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What happens if an error in BIA's estate... INDIAN PROBATE HEARINGS PROCEDURES Judicial Authority and Duties § 30.128 What happens if an error in BIA's estate inventory is alleged? This section applies when, during a probate proceeding, an interested...

  19. 25 CFR 171.310 - Can I use water delivered by BIA for livestock purposes?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I use water delivered by BIA for livestock purposes? 171.310 Section 171.310 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.310 Can I use water delivered by BIA for livestock...

  20. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  1. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Will BIA provide leaching service to me? 171.305 Section... OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide you leaching service if: (1) You submit a written plan that documents how soil salinity limits your...

  2. 76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

    Science.gov (United States)

    2011-01-25

    ... Deputation Agreements are effective on January 25, 2011. FOR FURTHER INFORMATION CONTACT: Charles Addington... http://www.bia.gov/WhoWeAre/BIA/OJS/index.htm . The documents were the subject of tribal consultation in November and December 2010. The Office of Justice Services continues consultation on the Tribal...

  3. 25 CFR 170.401 - What is BIA's role in transportation planning?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is BIA's role in transportation planning? 170.401... RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Transportation Planning § 170.401 What is BIA's role in transportation planning? Except as provided in § 170.402...

  4. 25 CFR 170.614 - Can a tribe receive funds before BIA publishes the notice of funding availability?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe receive funds before BIA publishes the notice... Contracts and Agreements Under Isdeaa § 170.614 Can a tribe receive funds before BIA publishes the notice of funding availability? A tribe can receive funds before BIA publishes the notice of funding availability...

  5. 24 CFR 202.3 - Approval status for lenders and mortgagees.

    Science.gov (United States)

    2010-04-01

    ... own portfolio or the portfolios of other mortgagees with which it has a servicing contract. (d... by the Secretary and signed by the mortgagee; (ii) Be accompanied by an independent analysis of the... and claim rate. The independent analysis must be prepared by an independent Certified Public...

  6. 23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

    Science.gov (United States)

    2010-04-01

    ... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available funding...

  7. Fast BIA-amperometric determination of isoniazid in tablets.

    Science.gov (United States)

    Quintino, Maria S M; Angnes, Lúcio

    2006-09-26

    This paper proposes a new, fast and precise method to analyze isoniazid based on the electrochemical oxidation of the analyte at a glassy carbon electrode in 0.1M NaOH. The quantification was performed utilizing amperometry associated with batch injection analysis (BIA) technique. Fast sequential analysis (60 determinations h(-1)) in an unusually wide linear dynamic range (from 2.5 x 10(-8) to 1.0 x 10(-3)M), with high sensitivity and low limits of detection (4.1 x 10(-9)M) and quantification (1.4 x 10(-8)M), was achieved. Such characteristics allied to a good repeatability of the current responses (relative standard deviation of 0.79% for 30 measurements), were explored for the specific determination of isoniazid in isoniazid-rifampin tablet.

  8. 25 CFR 103.36 - What options and remedies does the lender have if the borrower defaults on the loan?

    Science.gov (United States)

    2010-04-01

    ... result in the borrower curing the default. (b) The lender may make precautionary advances on the borrower... prospects do not significantly deteriorate. Items for which the lender may make precautionary advances include, for example: (1) Hazard, liability, or key man life insurance premiums; (2) Security measures to...

  9. 12 CFR 617.7315 - What records must the qualified lender maintain on behalf of the CRC?

    Science.gov (United States)

    2010-01-01

    ... on behalf of the CRC? 617.7315 Section 617.7315 Banks and Banking FARM CREDIT ADMINISTRATION FARM... must the qualified lender maintain on behalf of the CRC? A qualified lender must maintain a complete file of all requests for CRC reviews, including participation in state mediation programs, the minutes...

  10. 13 CFR 120.462 - What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders?

    Science.gov (United States)

    2010-01-01

    ... capital that each SBA Supervised Lender must maintain to protect against the credit risk and other general... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are SBA's additional requirements on capital maintenance for SBA Supervised Lenders? 120.462 Section 120.462 Business Credit and...

  11. BIA and DOD Schools: Student Achievement and Other Characteristics Often Differ from Public Schools

    National Research Council Canada - National Science Library

    2001-01-01

    ...) and the Department of Defense (DOD) school systems. Unlike public schools, where federal funding constitutes a small portion of total resources, the BIA and DOD school systems depend almost entirely on federal funds...

  12. BIA AND DOD SCHOOLS: Student Achievement and Other Characteristics Often Differ from Public Schools

    National Research Council Canada - National Science Library

    2001-01-01

    ...) and the Department of Defense (DOD) school systems. Unlike public schools, where federal funding constitutes a small portion of total resources, the BIA and DOD school systems depend almost entirely on federal funds...

  13. 22 Cases of BIA-ALCL: Awareness and Outcome Tracking from the Italian Ministry of Health.

    Science.gov (United States)

    Antonella, Campanale; Rosaria, Boldrini; Marcella, Marletta

    2017-09-13

    To date, 359 cases of anaplastic large cell lymphoma in women with breast implants (BIA-ALCL) worldwide have been reported out of more than 10 million implanted patients but Health Care Authorities suspect this is a possible underestimation and the limited number of cases makes it difficult to clarify its etiology. The General Directorate of Medical Devices and Pharmaceutical Services of the Italian Ministry of Health (IMoH) has examined and studied the Italian BIA-ALCL cases, and the aim of this study is to report on the knowledge and experience gained on this new emerging disease. An official document has been diffused by the IMoH to all the Italian medical associations, aiming at encouraging all physicians to notify each BIA-ALCL case through the compilation of a specific on-line form. A retrospective study has been performed on the notified BIA-ALCL cases collected in the IMoH's database named DISPOVIGILANCE. Research on DISPOVIGILANCE gives back a list of 22 Italian BIA-ALCL cases. The patients' mean age was 49.6 years (range 30 -71). The average time to the onset of the symptoms was 6.8 years (range 1-22). The average time to the diagnosis was 7.8 years (range 4 -22). The estimated incidence of the Italian BIA-ALCL cases related to 2015 is 2.8 per 100.000 patients. The BIA-ALCL pathogenesis remains unknown. The Italian Ministry of Health, together with scientific associations and other Competent Authorities worldwide, is working on the BIA-ALCL issue to increase awareness and knowledge of this disease by healthcare professionals.

  14. Książka o getcie białostockim

    DEFF Research Database (Denmark)

    Kerszman, Gustaw

    2014-01-01

    Remarks about the book: Rafael Rajzner, Henry R. Lew: Losy nieopowiedziane. Zagłada Żydów białostockich 1939-1945 (Żydowski Instytut Historyczny im. E. Ringelbluma : Warszawa 2013)......Remarks about the book: Rafael Rajzner, Henry R. Lew: Losy nieopowiedziane. Zagłada Żydów białostockich 1939-1945 (Żydowski Instytut Historyczny im. E. Ringelbluma : Warszawa 2013)...

  15. 13 CFR 120.213 - What fixed interest rates may a Lender charge?

    Science.gov (United States)

    2010-01-01

    ... Lender charge? 120.213 Section 120.213 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... have a reasonable fixed interest rate. SBA periodically publishes the maximum allowable rate in the... government determines the interest rate on direct loans. SBA publishes the rate periodically in the Federal...

  16. 34 CFR 682.411 - Lender due diligence in collecting guaranty agency loans.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Lender due diligence in collecting guaranty agency... due diligence in collecting guaranty agency loans. (a) General. In the event of delinquency on an FFEL... certification. (n) Due diligence for endorsers. (1) Before filing a default claim on a loan with an endorser...

  17. 34 CFR 601.12 - Use of institution and lender name.

    Science.gov (United States)

    2010-07-01

    ... such institution or organization, in the marketing of private education loans to students attending... 34 Education 3 2010-07-01 2010-07-01 false Use of institution and lender name. 601.12 Section 601.12 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF...

  18. 13 CFR 120.460 - What are SBA's additional requirements for SBA Supervised Lenders?

    Science.gov (United States)

    2010-01-01

    ... company and does not have its own board of directors) must adopt an internal control policy which provides... the SBA Supervised Lender regulations that follow. (b) Operations and internal controls. Each SBA... operations, programs, and resources. The internal control policy must, at a minimum: (1) Direct management to...

  19. 75 FR 80516 - Notice of Submission of Proposed Information Collection to OMB; Lender Qualifications for...

    Science.gov (United States)

    2010-12-22

    ... Proposed Information Collection to OMB; Lender Qualifications for Multifamily Accelerated Processing (MAP) AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: The proposed information... Number: 2502-0541. Form Numbers: None. Description of the Need for the Information and Its Proposed Use...

  20. 12 CFR 617.7415 - How does a qualified lender decide to restructure a loan?

    Science.gov (United States)

    2010-01-01

    ... restructure a loan? 617.7415 Section 617.7415 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Distressed Loan Restructuring; State Agricultural Loan Mediation Programs § 617.7415 How... the cost to the lender of restructuring the loan is equal to or less than the cost of foreclosure...

  1. 13 CFR 120.920 - Required participation by the Third Party Lender.

    Science.gov (United States)

    2010-01-01

    ...) Third Party Loan collateral. Third Party Loans usually are collateralized by a first lien on the Project... BUSINESS LOANS Development Company Loan Program (504) Third Party Loans § 120.920 Required participation by the Third Party Lender. (a) Amount of Third Party Loans. A Project financing must include one or more...

  2. 25 CFR 103.17 - Must the lender follow any special procedures to close the loan?

    Science.gov (United States)

    2010-04-01

    ... searches for each asset to be used as loan collateral. (c) At or prior to closing, the lender must obtain recent appraisals for all real property and improvements to be used as collateral for the loan, to the... instruments designed to document the loan, establish the basis for a security interest in loan collateral, and...

  3. Lending Policies of Informal, Formal, and Semi-formal Lenders: Evidence from Vietnam

    NARCIS (Netherlands)

    Lensink, B.W.; Pham, T.T.T.

    2007-01-01

    This paper compares lending policies of formal, informal and semiformal lenders with respect to household lending in Vietnam. The analysis suggests that the probability of using formal or semiformal credit increases if borrowers provide collateral, a guarantor and/or borrow for business-related

  4. Lending policies of informal, formal and semiformal lenders - Evidence from Vietnam

    NARCIS (Netherlands)

    Pham, Thi Thu Tra; Lensink, Robert

    2007-01-01

    This paper compares lending policies of formal, informal and semiformal lenders with respect to household lending in Vietnam. The analysis suggests that the probability of using formal or semiformal credit increases if borrowers provide collateral, a guarantor and/or borrow for business-related

  5. 24 CFR 1007.70 - Disqualification of lenders and civil money penalties.

    Science.gov (United States)

    2010-04-01

    ... civil money penalties. 1007.70 Section 1007.70 Housing and Urban Development Regulations Relating to....70 Disqualification of lenders and civil money penalties. (a) In general—(1) Grounds for action. HUD... or holder that are guaranteed under this part. (b) Civil money penalties for intentional violations...

  6. 76 FR 71329 - Request for Information Regarding Private Education Loans and Private Educational Lenders

    Science.gov (United States)

    2011-11-17

    ... Regarding Private Education Loans and Private Educational Lenders AGENCY: Bureau of Consumer Financial... Justice and the Federal Trade Commission, to prepare a Report on Private Education Loans and Private... Justice and the Federal Trade Commission, to prepare a Report on Private Education Loans and Private...

  7. Crisis management and lender of last resort in the European banking market

    NARCIS (Netherlands)

    Boot, A.W.A.; Marinč, M.

    2008-01-01

    We discuss some key issues related to supervisory arrangements in the Euro-system countries. In particular, we address the lender of last resort (LOLR) structure and the related crisis management framework. We focus on the responsibilities and powers of individual countries (and national central

  8. Crisis management and lender of last resort in the European banking market

    NARCIS (Netherlands)

    Boot, A.W.A.; Marinč, M.; Alessandrini, P.; Fratianni, M.; Zazzaro, A.

    2009-01-01

    We discuss some key issues related to supervisory arrangements in the Euro-system countries. In particular, we address the lender of last resort (LOLR) structure and the related crisis management framework. We focus on the responsibilities and powers of individual countries (and national central

  9. Morphotectonic control of the Białka drainage basin (Central Carpathians: Insights from DEM and morphometric analysis.

    Directory of Open Access Journals (Sweden)

    Wołosiewicz Bartosz

    2016-06-01

    Full Text Available The Białka river valley is directly related to a deep NNW-SSE oriented fault zone. According to the results of previous morphometric analyses, the Białka drainage basin is one of the most tectonically active zones in the Central Carpathians. It is also located within an area of high seismic activity.

  10. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Science.gov (United States)

    2010-04-01

    ... Transportation Facility Maintenance Program A Appendix A to Subpart G Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance Pt. 170... Transportation Facility Maintenance Program The following activities are eligible for BIA Transportation Facility...

  11. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Science.gov (United States)

    2010-04-01

    ... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.807 What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System...

  12. 25 CFR 171.420 - Can I dispose of sewage, trash, or other refuse on a BIA irrigation project?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I dispose of sewage, trash, or other refuse on a BIA... AND WATER IRRIGATION OPERATION AND MAINTENANCE Irrigation Facilities § 171.420 Can I dispose of sewage, trash, or other refuse on a BIA irrigation project? No. Sewage, trash, or other refuse are considered...

  13. The impact of the European insolvency regulation on lenders, lending decisions, the structuring of transactions and enforcement of security

    OpenAIRE

    Sharma, R

    2011-01-01

    This Thesis seeks to shed light on the issue of how far secured creditor rights are protected in EU cross-border insolvencies by focusing on the perspective and position of English lenders. The main thread throughout is the legal concerns faced by lenders when lending to a company incorporated in England and Wales which operates across the European Union and has assets and creditors spread across various Member States. The initial stages of the structuring of a cross-border security arrangeme...

  14. 25 CFR 115.422 - As a custodial parent, the legal guardian, the person who BIA has recognized as having control...

    Science.gov (United States)

    2010-04-01

    ... BIA has recognized as having control and custody of the minor, or an emancipated minor, what are your... BIA has recognized as having control and custody of the minor, or an emancipated minor, what are your... legal guardian, the person who BIA has recognized as having control and custody of the minor, or an...

  15. Literatura białoruska w Polsce po roku 1989. O potrzebie tworzenia bazy literackiej

    Directory of Open Access Journals (Sweden)

    Grażyna Charytoniuk-Michiej

    2014-12-01

    Full Text Available Belarusian literature in Poland after 1989. About the necessity of developing a literature database Speaking about Belarusian literature in Poland we focus on fiction, its translation into Polish and the study of literature. The existence of the Belarusian literature in Poland in the post-war period is indicated by the following bibliographies: a bibliography of translations for the period 1945–1994 (G. Charytoniuk, Literatura białoruska w Polsce. Bibliografia przekładów za lata 1945–1994, Białystok 1996 and a subject bibliography for the period 1945–1998 (G. Charytoniuk, Polskie białorutenika literackie. Bibliografia przedmiotowa 1945–1998, Białystok 1998. The new political, economical and social conditions in Poland after 1989 have had an influence on the situation of the Belarusian literature. In addition to the existing departments some new university departments and scientific branches have been organized. Their aim is to realize new scientific projects connected with the Belarusian literature in Poland and Belarus. A lot of nongovernment organizations (funds, partnerships, associations have been organized not only in Bialystok region, but also in the other parts of the country. A new publishing market has been established which has focused on the modern literature of Central and Eastern Europe including Belarusian literature. The Internet also plays an important role in popularization of the Belarusian literature. That literature has been included in the database of the National library (Przewodnik Bibliograficzny, Bibliografia Zawartości Czasopism, regional libraries (Bibliografia województwa podlaskiego and the digital library (Polska Bibliografia Literacka. The information is searched by institutional scientific depositories and digital libraries. The considerable part of the information has not been registered in the bibliographic database. In this situation it is necessary to develop an integral literature

  16. Financing biotechnology projects: lender due diligence requirements and the role of independent technical consultants.

    Science.gov (United States)

    Keller, J B; Plath, P B

    1999-01-01

    An increasing number of biotechnology projects are being brought to commercialization using conventional structured finance sources, which have traditionally only been available to proven technologies and primary industries. Attracting and securing competitive cost financing from mainstream lenders, however, will require the sponsor of a new technology or process to undergo a greater level of due diligence. The specific areas and intensity of investigation, which are typically required by lenders in order to secure long-term financing for biotechnology-based manufacturing systems, is reviewed. The processes for evaluating the adequacy of prior laboratory testing and pilot plant demonstrations is discussed. Particular emphasis is given to scale-up considerations and the ability of the proposed facility design to accommodate significant modifications, in the event that scale-up problems are encountered.

  17. The European central bank and the us federal reserve as lender of last resort

    Directory of Open Access Journals (Sweden)

    Herr Hansjörg

    2014-01-01

    Full Text Available Without a lender of last resort financial stability is not possible and systemic financial crises get out of control. During and after the Great Recession the US Federal Reserve System (Fed and the European Central Bank (ECB took on the role of lender of last resort in a comprehensive way. The Fed stabilised the financial system, including the shadow banking system. However, the chance to fundamentally restructure the financial system was not used. The ECB was confronted with sovereign debt crises and an incomplete integration of the European Monetary Union (EMU. It followed a kind of “muddling through” to keep the Euro area together. In the EMU not only a fundamental restructuring of the financial system is needed but also a deeper economic and political integration. The Fed and the ECB both were the most important institutions to avoid repetition of the 1930s.

  18. Why borrowers pay premiums to larger lenders: Empirical evidence from sovereign syndicated loans

    OpenAIRE

    Hallak, Issam

    2002-01-01

    All other terms being equal (e.g. seniority), syndicated loan contracts provide larger lending compensations (in percentage points) to institutions funding larger amounts. This paper explores empirically the motivation for such a price design on a sample of sovereign syndicated loans in the period 1990-1997. I find strong evidence that a larger premium is associated with higher renegotiation probability and information asymmetries. It hardly has any impact on the number of lenders though. Thi...

  19. Modeling code-interactions in bilingual word recognition: Recent empirical studies and simulations with BIA+

    NARCIS (Netherlands)

    Lam, K.J.Y.; Dijkstra, A.F.J.

    2010-01-01

    Daily conversations contain many repetitions of identical and similar word forms. For bilinguals, the words can even come from the same or different languages. How do such repetitions affect the human word recognition system? The Bilingual Interactive Activation Plus (BIA+) model provides a

  20. 25 CFR 170.805 - What are the local, tribal, and BIA roles in transportation facility maintenance?

    Science.gov (United States)

    2010-04-01

    ... transportation facility maintenance? 170.805 Section 170.805 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.805 What are the local... Road Maintenance dollars. ...

  1. 25 CFR 10.11 - How would someone detained or incarcerated, or their representative, get the BIA policies and...

    Science.gov (United States)

    2010-04-01

    ... are used for operations or maintenance programs, the BIA's policies, standards, and procedures will be... physical or mental condition of the person at time of incarceration. In these cases, the Inmate Handbook...

  2. 7 CFR Exhibit B to Subpart F of... - Suggested Outline for Seeking Information From Lenders on Credit Criteria for Graduation of...

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Suggested Outline for Seeking Information From Lenders... Seeking Information From Lenders on Credit Criteria for Graduation of Single Family Housing Loans Date... (CONTINUED) PROGRAM REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation...

  3. A massa gorda de risco afeta a capacidade aeróbia de jovens adolescentes

    Directory of Open Access Journals (Sweden)

    Luís Massuça

    2013-12-01

    Full Text Available OBJETIVO: Estudar o comportamento do sexo e os efeitos da idade e da massa gorda sobre a capacidade aeróbia de jovens adolescentes. MÉTODOS: Os 621 estudantes do ensino secundário participantes no estudo (14 aos 17 anos; feminino: n = 329, idade, 15,84 ± 0,92 anos; masculino: n = 292, idade, 15,82 ± 0,87 anos foram avaliados em duas categorias: morfologia (altura, peso e % massa gorda - %MG e aptidão física (capacidade aeróbia. As medições antropométricas foram realizadas de acordo com o protocolo descrito por Marfell-Jones e a %MG foi calculada por bioimpedância. A avaliação da capacidade aeróbia foi realizada com o teste aeróbio de corrida - PACER, e VO2máx relativo foi calculado utilizando a equação de Léger. Os resultados das avaliações foram classificados de acordo com os valores normativos das tabelas de referência da bateria de testes FITNESSGRAM® As técnicas estatísticas utilizadas foram: 1 cálculo de frequências; 2 teste t de Student para amostras independentes; e 3 ANOVA two-way seguida do teste post-hoc HSD de Bonferroni. RESULTADOS: 1 existem diferenças significativas entre sexos no que se refere à %MG e ao VO2máx; 2 durante a adolescência, o VO2máx estabiliza nos rapazes e sofre um declínio nas moças; 3 independentemente do sexo, a classe de %MG e a idade cronológica têm um efeito significativo sobre a capacidade aeróbia; e 4 em jovens adolescentes, com %MG de risco, a redução da %MG para níveis saudáveis parece resultar na melhoria da capacidade aeróbia. CONCLUSÃO: O impacto da %MG na capacidade aeróbia, reforça a importância da educação física escolar na promoção da saúde cardiovascular.

  4. 78 FR 40312 - 30-Day Notice of Proposed Information Collection: FHA TOTAL (Technology Open to Approved Lenders...

    Science.gov (United States)

    2013-07-03

    ... the FHA Transformation Program, Single Family Housing is moving the TOTAL Scorecard to the Mortgage... used throughout the industry and are therefore listed as industry standard business practice. The...-0059 will be affected in the two initial transformation phases and Informed Consumer Choice Notice and...

  5. Design and Development of a Portable WiFi enabled BIA device

    International Nuclear Information System (INIS)

    Kriz'aj, D; Baloh, M; Zagar, T; Brajkovic, R

    2013-01-01

    A bioimpedance device (BIA) for evaluation of sarcopenia – age related muscle mass loss – is designed, developed and evaluated. The requirements were based on lightweight design, flexible and user enabled incorporation of measurement protocols and WiFi protocol for remote device control, full internet integration and fast development and usage of measurement protocols. The current design is based on usage of a microcontroller with integrated AD/DA converters. The prototype system was assembled and the operation and connectivity to different handheld devices and laptop computers was successfully tested. The designed BIA device can be accessed using TCP sockets and once the connection is established the data transfer runs successfully at the specified speed. The accuracy of currently developed prototype is about 5% for the impedance modulus and 5 deg. for the phase for the frequencies below 20 kHz with an unfiltered excitation signal and no additional amplifiers employed.

  6. Oil price risk management in the 1990s - issues for producers and lenders

    International Nuclear Information System (INIS)

    Lambert, S.

    1994-01-01

    Oil prices have exhibited considerable volatility over the past five or ten years and the management of oil price risk has become an important factor in underpinning the viability of many oil producing operations from both a lender's and investor's perspective. Various oil based hedging products are now available to protect against such volatility, ranging from products which fix forward prices to option based arrangements which set a floor price but retain some (or all) of the potential upside. These products have particular relevance for petroleum companies with limited financial resources or who are looking to limit recourse to particular assets/cash flows. There are a number of techniques which can be successfully combined to mitigate oil price volatility and the most relevant of these to a producer are discussed. The recent development of the Tapis swap and option markets, which have provided flexibility to Australasian producers, is also discussed. Oil based financial products can also be used as a method of funding (e.g. for a development or acquisition) as an alternative to traditional cash based borrowing structures, thus creating a natural hedge against oil price movements. It is estimated that the use of such structures, coupled with a well structured revenue hedging program, can enhance a project's attractiveness from a lender's perspective (particularly with respect to protection against down side movements in oil price) and/or provide greater certainty of returns to producers. A case study of a recent commodity risk management based financing is presented. 1 fig., 6 tabs

  7. Smart Multi-Frequency Bioelectrical Impedance Spectrometer for BIA and BIVA Applications.

    Science.gov (United States)

    Harder, Rene; Diedrich, Andre; Whitfield, Jonathan S; Buchowski, Macie S; Pietsch, John B; Baudenbacher, Franz J

    2016-08-01

    Bioelectrical impedance analysis (BIA) is a noninvasive and commonly used method for the assessment of body composition including body water. We designed a small, portable and wireless multi-frequency impedance spectrometer based on the 12 bit impedance network analyzer AD5933 and a precision wide-band constant current source for tetrapolar whole body impedance measurements. The impedance spectrometer communicates via Bluetooth with mobile devices (smart phone or tablet computer) that provide user interface for patient management and data visualization. The export of patient measurement results into a clinical research database facilitates the aggregation of bioelectrical impedance analysis and biolectrical impedance vector analysis (BIVA) data across multiple subjects and/or studies. The performance of the spectrometer was evaluated using a passive tissue equivalent circuit model as well as a comparison of body composition changes assessed with bioelectrical impedance and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Our results show an absolute error of 1% for resistance and 5% for reactance measurements in the frequency range of 3 kHz to 150 kHz. A linear regression of BIA and DXA fat mass estimations showed a strong correlation (r(2)=0.985) between measures with a maximum absolute error of 6.5%. The simplicity of BIA measurements, a cost effective design and the simple visual representation of impedance data enables patients to compare and determine body composition during the time course of a specific treatment plan in a clinical or home environment.

  8. 7 CFR Appendix H to Subpart E of... - Suggested Format for the Opinion of the Lender's Legal Counsel

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Suggested Format for the Opinion of the Lender's Legal Counsel H Appendix H to Subpart E of Part 1980 Agriculture Regulations of the Department of Agriculture... Industrial Loan Program Pt. 1980, Subpt. E, App. H Appendix H to Subpart E of Part 1980—Suggested Format for...

  9. 12 CFR 221.119 - Applicability of plan-lender provisions to financing of stock options and stock purchase rights...

    Science.gov (United States)

    2010-01-01

    ... experience that in some nonqualified plans, particularly stock purchase plans, the credit arrangement is... financing of stock options and stock purchase rights qualified or restricted under Internal Revenue Code... PURCHASING OR CARRYING MARGIN STOCK (REGULATION U) Interpretations § 221.119 Applicability of plan-lender...

  10. 12 CFR 617.7105 - When must a qualified lender disclose the effective interest rate to a borrower?

    Science.gov (United States)

    2010-01-01

    ... effective interest rate to a borrower? 617.7105 Section 617.7105 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Disclosure of Effective Interest Rates § 617.7105 When must a qualified lender disclose the effective interest rate to a borrower? (a) Disclosure to prospective borrowers...

  11. TARGET2 Imbalances and the ECB as Lender of Last Resort

    Directory of Open Access Journals (Sweden)

    Francesco Purificato

    2015-10-01

    Full Text Available This paper analyses the issue of the dynamics of the TARGET2 system balances during the sovereign debt crisis, when some countries registered a decisive inflow of the central bank liquidity and others showed an outflow. The dynamics in the TARGET2 are here explained as being due to a fall in the level of confidence in the capacity of the Economic and Monetary Union to survive, rather than to disparities in the level of competitiveness among countries of the Eurozone. This crisis of confidence has to be considered as the consequence of the implicit refusal of the European institutions to create a mechanism working as lender of last resort for the euro area member States; indeed, only when the ECB took this responsibility by launching the Outright Monetary Transactions clear signs of improvement were observed in the sovereign debt crisis.

  12. 25 CFR 161.610 - What will BIA do if livestock is not removed when a permit expires or is cancelled?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What will BIA do if livestock is not removed when a permit expires or is cancelled? 161.610 Section 161.610 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... will BIA do if livestock is not removed when a permit expires or is cancelled? If the livestock is not...

  13. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Science.gov (United States)

    2010-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application... Tribe/Consortium in drafting its planning grant application? 1000.68 Section 1000.68 Indians OFFICE OF... planning grant application? Yes, upon request from the Tribe/Consortium, a non-BIA bureau may provide...

  14. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Science.gov (United States)

    2010-04-01

    ...: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its... notice of its decision to restrict your account, the only information the public notice will include is... 25 Indians 1 2010-04-01 2010-04-01 false What information will the BIA include in its notice of...

  15. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the BIA notify you or your guardian, as... guardian, as applicable, of its decision to restrict your IIM account? The BIA will notify you or your guardian, as applicable, of its decision to restrict your IIM account by: (a) United States certified mail...

  16. 25 CFR 115.423 - If you are a custodial parent, a legal guardian, or an emancipated minor, may BIA authorize the...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false If you are a custodial parent, a legal guardian, or an emancipated minor, may BIA authorize the disbursement of funds from a minor's supervised account without your... custodial parent, a legal guardian, or an emancipated minor, may BIA authorize the disbursement of funds...

  17. Detection of muscle gap by L-BIA in muscle injuries: clinical prognosis.

    Science.gov (United States)

    Nescolarde, L; Yanguas, J; Terricabras, J; Lukaski, H; Alomar, X; Rosell-Ferrer, J; Rodas, G

    2017-06-21

    Sport-related muscle injury classifications are based basically on imaging criteria such as ultrasound (US) and magnetic resonance imaging (MRI) without consensus because of a lack of clinical prognostics for return-to-play (RTP), which is conditioned upon the severity of the injury, and this in turn with the muscle gap (muscular fibers retraction). Recently, Futbol Club Barcelona's medical department proposed a new muscle injury classification in which muscle gap plays an important role, with the drawback that it is not always possible to identify by MRI. Localized bioimpedance measurement (L-BIA) has emerged as a non-invasive technique for supporting US and MRI to quantify the disrupted soft tissue structure in injured muscles. To correlate the severity of the injury according to the gap with the RTP, through the percent of change in resistance (R), reactance (Xc) and phase-angle (PA) by L-BIA measurements in 22 muscle injuries. After grouping the data according to the muscle gap (by MRI exam), there were significant differences in R between grade 1 and grade 2f (myotendinous or myofascial muscle injury with feather-like appearance), as well as between grade 2f and grade 2g (myotendinous or myofascial muscle injury with feather and gap). The Xc and PA values decrease significantly between each grade (i.e. 1 versus 2f, 1 versus 2g and 2f versus 2g). In addition, the severity of the muscle gap adversely affected the RTP with significant differences observed between 1 and 2g as well as between 2f and 2g. These results show that L-BIA could aid MRI and US in identifying the severity of an injured muscle according to muscle gap and therefore to accurately predict the RTP.

  18. Functional Characterization of 4´OMT and 7OMT Genes in BIA Biosynthesis

    Directory of Open Access Journals (Sweden)

    Tugba eGurkok

    2016-02-01

    Full Text Available Alkaloids are diverse group of secondary metabolites generally found in plants. Opium poppy (Papaver somniferum L., the only commercial source of morphinan alkaloids, has been used as a medicinal plant since ancient times. It produces benzylisoquinoline alkaloids (BIA including the narcotic analgesic morphine, the muscle relaxant papaverine, and the anti-cancer agent noscapine. Though BIAs play crucial roles in many biological mechanisms their steps in biosynthesis and the responsible genes remain to be revealed. In this study, expressions of 3-hydroxy-N-methylcoclaurine 4´-O-methyltransferase (4´OMT and reticuline 7-O-methyltransferase (7OMT genes were subjected tomanipulation to functionally characterize their roles in BIA biosynthesis. Measurements of alkaloid accumulation were performed in leaf, stem and capsule tissues accordingly. Suppression of 4´OMT expression caused reduction in the total alkaloid content in stem tissue whereas total alkaloid content was significantly induced in the capsule. Silencing of the 7OMT gene also caused repression in total alkaloid content in the stem. On the other hand, over-expression of 4´OMT and 7OMT resulted in higher morphine accumulation in the stem but suppressed amount in the capsule. Moreover, differential expression in several BIA synthesis genes (CNMT, TYDC, 6OMT, SAT, COR, 4´OMT and 7OMT were observed upon manipulation of 4´OMT and 7OMT expression. Upon silencing and overexpression applications, tissue specific effects of these genes were identified. Manipulation of 4´OMT and 7OMT genes caused differentiated accumulation of BIAs including morphine and noscapine in capsule and stem tissues.

  19. Od internacjonalnej do własnej historii – mniejszość białoruska w Polsce

    Directory of Open Access Journals (Sweden)

    Wojciech Śleszyński

    2017-12-01

    Full Text Available From international history to one’s own history – Belorusian minority in Poland After World War II the Belarusians who did not leave Poland could gain upward mobility only if they avoided displaying their national and cultural distinctiveness. Belarusians made a political choice which coincided with a vision of history and thus accepted a historical narrative spread by communist circles. The narrative constructed by the Belarusian minority was consistent with the officially proclaimed state ideological narrative. It contained mostly the history of the Communist Party of Western Belarus and described a difficult situation of Belarus in the Second Polish Republic and during World War II (especially the Great Patriotic War. The Belarusian community made first attempts to rebuild the current vision of the world in 1980–1981. Students tried to create an alternative historical narrative that contradicted the communist one. However, it was a gradual collapse of the communist system that became an impetus for more active development of the Belarusian minority in Poland, and consequently, the creation of its own national vision of history. The Belarusian heritage has been based on the Belarusian People's Republic and the Grand Duchy of Lithuania, and not, as it was in the Soviet Socialist Republic of Belarus or after 1994, on the Republic of Belarus and the victory in the Great Patriotic War.   Od internacjonalnej do własnej historii – mniejszość białoruska w Polsce Pozostała w Polsce po II wojnie światowej społeczność białoruska uzyskała możliwość awansu społecznego pod warunkiem nieeksponowania swojej narodowej i kulturowej odrębności. Białorusini, dokonując wyboru politycznego, pokrywającego się z wyborem wizji historii, akceptowali obraz dziejów prezentowany przez środowiska komunistyczne. Konstruowany przez mniejszość białoruską przekaz historyczny zgodny był z oficjalnie głoszonym państwowym przekazem

  20. Zakład Medycyny Sądowej w Bielsku-Białej

    Directory of Open Access Journals (Sweden)

    Jerzy Brzyski

    2014-10-01

    Full Text Available Zakład Medycyny Sądowej w Bielsku-Białej został utworzony w 1978 roku. Podstawą dla jego utworzenia i wpisania w strukturę Wojewódzkiego Szpitala Zespolonego były wytyczne Ministra Zdrowia i Opieki Społecznej z dnia 15.06.1978 roku w sprawie organizacji i zadań komórek medycyny sądowej (Dz.U. MZiOS Nr 11, poz 28.

  1. 24 CFR 202.5 - General approval standards.

    Science.gov (United States)

    2010-04-01

    ... lenders or mortgagees in §§ 202.6 through 202.10. (a) Business form. The lender or mortgagee shall be a corporation or other chartered institution, a permanent organization having succession or a partnership. A.... (f) Business changes. The lender or mortgagee shall provide prompt notification to the Secretary of...

  2. Species of lichenized and allied fungi new to Białowieża Large Forest (NE Poland

    Directory of Open Access Journals (Sweden)

    Krystyna Czyżewska

    2014-08-01

    Full Text Available The paper presents 38 species of lichenized and allied fungi new to Białowieża Large Forest. 24 taxa of lichenized Ascomycota and 14 taxa of lichenicolous and saprobic fungi are the result of the analysis of collected materials as well as additional field studies.

  3. 25 CFR 161.713 - How will BIA determine the amount of damages to Navajo Partitioned Lands?

    Science.gov (United States)

    2010-04-01

    ... per month for comparable property or grazing privileges, or the estimated commercial value or replacement costs of the products or property. (c) BIA will determine the value of the products or property illegally used or removed based upon a valuation of similar products or property. ...

  4. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Science.gov (United States)

    2010-04-01

    ... property, including your financial affairs;” or (3) Determines through an administrative process that you... professional that you are “incapable of managing or administering property, including your financial affairs... IIM funds as security/collateral for the transaction; (ii) A copy of the document showing that the BIA...

  5. 25 CFR 166.819 - What happens if the BIA does not collect enough money to satisfy the penalty?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What happens if the BIA does not collect enough money to... does not collect enough money to satisfy the penalty? We will send written notice to the trespasser demanding immediate settlement and advising the trespasser that unless settlement is received within five...

  6. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

    NARCIS (Netherlands)

    van Esbroeck, Annelot C M; Janssen, Antonius P A; Cognetta, Armand B; Ogasawara, Daisuke; Shpak, Guy; van der Kroeg, Mark; Kantae, Vasudev; Baggelaar, Marc P; de Vrij, Femke M S; Deng, Hui; Allarà, Marco; Fezza, Filomena; Lin, Zhanmin; van der Wel, Tom; Soethoudt, Marjolein; Mock, Elliot D; den Dulk, Hans; Baak, Ilse L; Florea, Bogdan I; Hendriks, Giel; De Petrocellis, Luciano; Overkleeft, Herman S; Hankemeier, Thomas; De Zeeuw, Chris I; Di Marzo, Vincenzo; Maccarrone, Mauro; Cravatt, Benjamin F; Kushner, Steven A; van der Stelt, Mario

    2017-01-01

    A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe neurological symptoms in four others. Although the cause of the clinical neurotoxicity is unknown, it has been postulated, given the clinical safety

  7. 25 CFR 171.500 - How does BIA determine the annual operation and maintenance assessment rate for the irrigation...

    Science.gov (United States)

    2010-04-01

    ... costs needed for the reliable operation of the irrigation facility infrastructure; (8) Maintenance of a... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA determine the annual operation and... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND...

  8. Post-crisis Belarus: Marxism and the lender of last resort

    Directory of Open Access Journals (Sweden)

    Heather Bell

    2015-07-01

    Full Text Available Existing literature has examined the predictions and proscriptions of Karl Marx in response to the 2008 global financial crisis. However, the suggestions put forth by the Marxist-leaning literature never took hold and state-level banking and finance policies have remained largely unchanged. While many criticisms of Marxism exist, this paper examines Belarus, a ‘neo-communist’ or ‘market-socialist’ state, to provide a new perspective on the continuation of capitalism in the United States and Europe. In the case of Belarus, the International Monetary Fund and the Eurasian Economic Community's Anti-Crisis Fund provided both the critical liquidity needed to temporarily quell the effects of the financial crisis. Their demands meant that Belarus agreed to speed its move away from the Soviet-era finance and banking policies and more towards its western capitalist neighbors. Its failure to implement these policies further hurt its recovery. Examining Belarus' path to and out of its financial crisis makes apparent that the role of the international lender of last resort (LOLR. The LOLR acts as a key element in protecting states embroiled in the financial crisis from facing the possibility of making the difficult policy changes put forth by the Marxist literature. By ignoring its promises under the loan conditions from its LOLRs, Belarus moved further from the recovery promised by the Marxist suggestions.

  9. POTÊNCIA E CAPACIDADE ANAERÓBIA EM ATLETAS DE KARATE

    Directory of Open Access Journals (Sweden)

    Keith Sato Urbinati

    2011-01-01

    Full Text Available O objetivo do presente estudo foi verificar o nível de potência muscular, bem como a intensidade de esforço durante prova de potência e capacidade anaeróbia em atletas de Karate. Participaram do estudo treze karatekas especialistas em prova de kumitê (luta,sexo masculino, idade média de 20,7±3,79 anos. Realizou-se a avaliação de potência e capacidade anaeróbia (Wingate test, com coleta das variáveis fisiológicas:frequência cardíaca (FC, pressão arterial (PA e lactato sanguíneo (LAC de repouso, imediatamente após e em 5 min de recuperação. Para verificar se ocorrem diferenças nas variáveis fisiológicas durante o teste, realizou-se análise de variância, post hoc de Bonferronie (p?0,05. Verificou-se potência de pico(PP de 8,77 ± 0,99 W/kg-1, potência média (PM de 5,13± 0,49 W.kg-1 e % de fadiga de 50,5 ± 6,45%. Para as variáveis fisiológicas,a FC (F=9,79; p=0,00 pós-teste de Wingate foi estatisticamente maior e diferenteda FC de repouso e recuperação. Não foram encontradas diferenças nos níveis pressatórios e nas concentrações de LAC. Em relação aos valores de FC e LAC tais variáveis pós-teste não se apresentaram elevados. Os valores de potência anaeróbia estão de acordo com a necessidade da modalidade esportiva. Assim, verificou-se menores intensidades de esforço em teste de Wingate quando comparados a de situação real de competição. O nível de potência muscular parece estar adequado ao kumitê.

  10. 42 CFR 60.42 - Records, reports, inspection, and audit requirements for HEAL lenders and holders.

    Science.gov (United States)

    2010-10-01

    ... security and protected from fire, flood, water leakage, other environmental threats, electronic data system... Investigations. (Approved by the Office of Management and Budget under control numbers 0915-0043 and 0915-0108...

  11. Business English in the Eyes of Economics and Management Students at the University of Białystok

    Directory of Open Access Journals (Sweden)

    Dzięcioł-Pędich Agnieszka

    2014-09-01

    Full Text Available According to the regulations of the Polish Ministry of Science and Higher Education, university graduates should have to know a foreign language at B2 level, as described in The Common European Framework of Reference, and they should know its specialized variety. These are the only recommendations concerning general language courses and their specialized varieties. It is up to schools of foreign languages or other institutions providing language courses for institutions of higher education to determine requirements concerning language for specific purposes. However, students are rarely asked to contribute to the development of curricula and syllabi. This article presents the results of a survey conducted among students of Economics and Management at the University of Białystok. The survey was devoted to students’ perceptions of Business English in English courses conducted by the School of Foreign Languages at the University of Białystok. The aim of the survey was to answer the following questions:

  12. The role of lenders' trust in determining borrowing conditions for sovereign debt: An analysis of one-period government bonds with default risk

    OpenAIRE

    Guo, Yanling

    2015-01-01

    In this paper, the author considers the sovereign debt in the form of one-period government bonds with default risk, which can be purchased by and traded among domestic and foreign investors. She shows that the weight assigned to the lenders' interest by the borrowing government at the time of debt repayment, which captures the lenders' trust in the government's propensity to repay the debt and is denoted as », also determines the default risk: a higher » means a lower default risk ceteris pa...

  13. Redfield Energy Approval

    Science.gov (United States)

    This September 19, 2016 letter from EPA approves the petition from Poet Biorefining-Lake Crystal, regarding non-This October 27, 2016 letter from EPA approves the petition from Redfield Energy, LLC, regarding non-grandfathered ethanol produced

  14. Utilization of BIA-Derived Bone Mineral Estimates Exerts Minimal Impact on Body Fat Estimates via Multicompartment Models in Physically Active Adults.

    Science.gov (United States)

    Nickerson, Brett S; Tinsley, Grant M

    2018-03-21

    The purpose of this study was to compare body fat estimates and fat-free mass (FFM) characteristics produced by multicompartment models when utilizing either dual energy X-ray absorptiometry (DXA) or single-frequency bioelectrical impedance analysis (SF-BIA) for bone mineral content (BMC) in a sample of physically active adults. Body fat percentage (BF%) was estimated with 5-compartment (5C), 4-compartment (4C), 3-compartment (3C), and 2-compartment (2C) models, and DXA. The 5C-Wang with DXA for BMC (i.e., 5C-Wang DXA ) was the criterion. 5C-Wang using SF-BIA for BMC (i.e., 5C-Wang BIA ), 4C-Wang DXA (DXA for BMC), 4C-Wang BIA (BIA for BMC), and 3C-Siri all produced values similar to 5C-Wang DXA (r > 0.99; total error [TE] FFM characteristics (i.e., FFM density, water/FFM, mineral/FFM, and protein/FFM) for 5C-Wang DXA and 5C-Wang BIA were each compared with the "reference body" cadavers of Brozek et al. 5C-Wang BIA FFM density differed significantly from the "reference body" in women (1.103 ± 0.007 g/cm 3 ; p FFM and mineral/FFM were significantly lower in men and women when comparing 5C-Wang DXA and 5C-Wang BIA with the "reference body," whereas protein/FFM was significantly higher (all p ≤ 0.001). 3C-Lohman BIA and 3C-Lohman DXA produced error similar to 2C models and DXA and are therefore not recommended multicompartment models. Although more advanced multicompartment models (e.g., 4C-Wang and 5C-Wang) can utilize BIA-derived BMC with minimal impact on body fat estimates, the increased accuracy of these models over 3C-Siri is minimal. Copyright © 2018 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.

  15. An Annotated And Illustrated Catalogue Of Polypores (Agaricomycetes Of The Białowieża Forest (NE Poland

    Directory of Open Access Journals (Sweden)

    Karasiński Dariusz

    2015-12-01

    Full Text Available The Białowieża Forest (BF is one of the best-preserved lowland deciduous and mixed forest complexes in Europe, rich in diverse fungi. This paper summarizes what is known about the poroid fungi of the Polish part of the Białowieża Forest, based on literature data, a re-examination of herbarium materials, and the authors’ studies from 1990–2014. An annotated catalogue of polypores recorded in the forest is presented, including 80 genera with 210 species. All literature and herbarium records are enumerated, and 160 species are illustrated with color pictures. Fourteen species previously reported in the literature have uncertain status because they lack voucher specimens and were not confirmed in recent field studies. Antrodiella subradula (Pilát Niemelä & Miettinen, previously known from Asia, is reported for the first time from Europe. Fourteen species are newly reported from the Białowieża Forest (mainly from Białowieża National Park, including 8 species with first records in Poland (Antrodia hyalina Spirin, Miettinen & Kotir., Antrodia infirma Renvall & Niemelä, Antrodiella subradula, Junghuhnia fimbriatella (Peck Ryvarden, Postia folliculocystidiata (Kotl. & Vampola Niemelä & Vampola, Postia minusculoides (Pilát ex Pilát Boulet, Skeletocutis chrysella Niemelä, Skeletocutis papyracea A. David, and 6 species reported previously from other localities in Poland [Antrodiella faginea Vampola & Pouzar, Dichomitus campestris (Quél. Domański & Orlicz, Loweomyces fractipes (Berk. & M. A. Curtis Jülich, Oxyporus latemarginatus (Durieu & Mont. Donk, Perenniporia narymica (Pilát Pouzar, Phellinus nigricans (Fr. P. Karst.]. Several very rare European polypores already reported from the Białowieża Forest in the 20th century, such as Antrodia albobrunnea (Romell Ryvarden, Antrodiella foliaceodentata (Nikol. Gilb. & Ryvarden, Buglossoporus pulvinus (Pers. Donk, Dichomitus albidofuscus (Domański Domański and Gelatoporia subvermispora

  16. 77 FR 77050 - Agency Information Collection Activities; Part 601 Preferred Lender Arrangements

    Science.gov (United States)

    2012-12-31

    ... the use of information technology. Please note that written comments received in response to this... previously approved information collection. Respondents/Affected Public: Individuals or households. Total... about the applicant's cost of attendance and estimated financial assistance must be provided to the...

  17. Synanthropization of dendroflora near main roads in Białystok (NE Poland

    Directory of Open Access Journals (Sweden)

    Łaska Grażyna

    2015-06-01

    Full Text Available The aim of the study was to analyze the species composition of the dendroflora near four main roads in the city of Białystok, taking into regard their geographical and historical origin. The wildlife inventory was conducted in the vegetation season of 2011. The inventory revealed presence of a total of 837 trees and bushes representing 36 species and 18 families. The most abundant trees were those from the family Aceraceae (63.8%, while the most abundant bushes were those representing Rosaceae (48.9%. The contribution of native species (65.7% was found to be about twice as high as that of alien ones (34.3%. The dominant species among the native trees was Acer platanoides L., while the principal bush species was Crataegus monogyna Jacq. The alien tree species were most commonly represented by Acer negundo L., and bushes - by Ligustrum vulgare L. Spontaneously settled trees and bushes were clearly dominant (59.9% over those originating from plantations (40.1%. Among the native species of local origin, the prevailing species were synanthropic spontaneophytes (52%, including Acer platanoides and Tilia cordata Mill. Anthropophytes were more abundantly represented by diaphytes (22.7%, followed by kenophytes (10.4%. The most abundant species among diaphytes was Ligustrum vulgare, and among kenophytes - Acer negundo.

  18. Bioelectrical impedance analysis (BIA) for sarcopenic obesity (SO) diagnosis in young female subjects

    International Nuclear Information System (INIS)

    González-Correa, C H; Caicedo-Eraso, J C; Villada-Gomez J S

    2013-01-01

    Sarcopenia is defined as a loss of muscle mass depending of ageing and affecting physical function (definition A). A new definition considers excluding mass reduction criterion (definition B). Obesity is pandemic and occurs at all ages. Sarcopenic obesity (SO) implies both processes. The purpose of this study was to compare the results obtained after applying these 2 definitions in 66 aged 22 ± 2.8 years overweight or obese young college women. Percentage body fat (%BF) and skeletal mass index (SMI) were estimated by BIA, muscle function by handgrip strength test (HGS) and physical performance by Harvard step test (HST). There were 9.1% and 90.9% overweight or obese subjects. Twenty nine subjects (43.9%) had decreased HGS and 22 (33.3%) had impaired physical performance. One obese subject (1.5%) met the criteria for sarcopenic obesity by definition A and 9 (13.6%) by definition B. Although a linear regression (α 2 = 0.094, 0.037 and 0.275 respectively) it was observed a tendency for HGS, HST and SMI deterioration when %BF increases. However, other confounding factors must be investigated. Probably as the population gets more obese, the problematic of SO will be found earlier in life.

  19. 12 CFR 617.7410 - When and how does a qualified lender notify a borrower of the right to seek loan restructuring?

    Science.gov (United States)

    2010-01-01

    ... borrower of the right to seek loan restructuring? 617.7410 Section 617.7410 Banks and Banking FARM CREDIT... Mediation Programs § 617.7410 When and how does a qualified lender notify a borrower of the right to seek... been identified as distressed and that the borrower has the right to request a restructuring of the...

  20. Small Businesses Save Big: A Guide to Help SBA Lenders Understand and Communicate the Value of Energy Efficiency Investments (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-01-01

    Dollars saved through energy efficiency can directly impact your bottom line. Whether you are planning for a major renovation or upgrading individual pieces of building equipment, these improvements can help reduce operating costs, save on utility bills, and boost profits. This fact sheet provides guidelines for SBA lenders to understand the value of financing energy efficiency investments.

  1. Influence of acute consumption of caffeine vs. placebo over Bia-derived measurements of body composition: a randomized, double-blind, crossover design.

    Science.gov (United States)

    Williamson, Cassie M; Nickerson, Brett S; Bechke, Emily E; McLester, Cherilyn N; Kliszczewicz, Brian M

    2018-01-01

    Bioelectrical impedance analysis (BIA) is often used to estimate total body water (TBW), intracellular body water (ICW), extracellular body water (ECW), and body fat percentage (BF%). A common restriction for BIA analysis is abstinence from caffeine 12-h prior to testing. However, research has yet to determine whether the consumption of caffeine influences BIA testing results. The purpose of this study was to determine if the consumption of caffeine influences BIA-derived BF% and body water values in habitual caffeine users. Twenty apparently healthy males (26.6 ± 4.1 years) identified as habitual caffeine consumers (≥ one 95 mg serving per day ≥ four days per week) participated in this study. Participants came to the lab on three occasions, the first visit serving as the control (CON) with no supplementation. The remaining two visits were performed in a randomized double-blind, cross-over fashion. Participants consumed 200 mg of dextrose (PLA) or caffeine (CAF) in capsule form. During each visit, seven multi-frequency BIA measurements were conducted before (PRE) and after (15-min, 30-min, 45-min, 60-min, 75-min, 90-min) consumption. Repeated measures ANOVA revealed BF% for CAF was lower than the CON and PLA conditions at PRE and 15-min ( p  Caffeine consumption in habitual users produced trivial changes in TBW, ECW, ICW, or BF%. Therefore, the pre-testing guidelines for caffeine consumption may not be necessary in habitual caffeine consumers.

  2. ARE SMES MORE CONFORTABLE WITH SMALL DOMESTIC LENDERS? (II –EVIDENCE FOR ROMANIAN SMES

    Directory of Open Access Journals (Sweden)

    Badulescu Daniel

    2012-12-01

    Full Text Available Based on a consistent literature presented in the previous part of our paper, and analysing our research results, carried out on a significant number of SMEs from Romania in 2011, the purpose of this paper is to examine how SMEs are affected and how they perceive the bank involvement in financing SMEs needs, in terms of the nature and characteristics of organizational structure of these lenders. We have found that, despite of the recent development of the crisis and the decision of the most of important European banks to reduce theirs involvement in Central and Eastern Europe, the mostly of the Romanian SMEs considered they are not ignored or under-privileged by large, international banks operating in Romania.

  3. Archives of Voivodship Committee of Polish United Workers’ Party in Biała Podlaska

    Directory of Open Access Journals (Sweden)

    Dariusz Magier

    2010-12-01

    Full Text Available Documentation generated by the communist party after World War II constituted the part of Polish archival heritage. However, Party’s archives were not supervised by nationalarchival network. At the beginning they were storehouses of acts, and since 1955 they had been taken over by propaganda sections of voivodship committees of PZPR (Polish United Workers’ Party and later transformed into the archives of voivodship committees of the Party. The task to preserve documentation generated by the structures of the communist party in Poland was subsequently supervised by: Party HistoryInstitute at KC PZPR (Central Committee of Polish United Workers’ Party, Archives of KC PZPR, and since 1971 Central Archives of KC PZPR. Together with the archives of voivodship committees the net with its own regulations, staff and archival methodology was created. This article gives a detailed description of the activity of the organizational unit,that is the archives of the voivodship committee of the communist party. One of the smallest committees existing in Poland, a provincial Voivodship Committee of PZPR in Biała Podlaska, which operated from 1975 to 1990, serves as an example. The article discusses the reporting structure, handing-over, analysis and preservation of acts, means of recording, premises, system of training and control as well as characterizes the role of a supervisor of the Party’s voidovdship committee Archives played in the archives and chancery.

  4. Analysis of activity in swine producers group based on agricultural producers association in Biała district

    Directory of Open Access Journals (Sweden)

    Damian Knecht

    2013-03-01

    Full Text Available The process of pigs producer groups formation in Poland is quite dynamic. Currently on the pork market 181 groups operate, which includes about 4000 swine producers. The aim of this study was to characterize the activities of the Agricultural Producers Association in Biała District. The research tool was a personal questionnaire and the research sample consisted of 30 farmers. It has been shown that after joining the producers group, the investigated households reported an increase in sales volume and improved the flock production parameters. Majority of the respondents were not satisfied with the cooperation with meat processing companies.

  5. Impact of the Pb and Zn ore mining industry on the pollution of the Biała Przemsza River, Poland.

    Science.gov (United States)

    Jabłońska-Czapla, Magdalena; Nocoń, Katarzyna; Szopa, Sebastian; Łyko, Aleksandra

    2016-05-01

    The development of mining and metallurgic industries of Pb and Zn ores in the Biała Przemsza catchment area has had a strong influence on the condition of the surface water and bottom sediments. In the following study, total contents of metals and metalloids were researched in the water and bottom sediment samples from the Biała Przemsza River. The samples were collected monthly in 2014 at five sampling points along the river. The research helped to determine correlations between the parameters and components of the water environment (metals/metalloids, cations/anions, pH, Eh, conductivity, carbon (TOC, IC, TC), and suspension). The contents of metals and metalloids were determined with inductively coupled plasma-mass spectrometry (ICP-MS), whereas anions and cations were investigated with ion chromatography (IC). The simplified Community Bureau of Reference (BCR) three-step sequential chemical extraction was performed on Biała Przemsza River bottom sediments collected in April, July, and October. At its lower course, the Biała Przemsza River water did not meet the Polish surface water quality standards. The Biała Przemsza River water is mainly loaded with metals. Toxic concentrations of Cd, Pb, and Zn were observed at sampling points in Okradzionów and Sławków. The toxic Tl concentration was exceeded (2-6 μg/L) at three sampling points. The Biała Przemsza River bottom sediments were composed mostly of medium and fine sand. The BCR extraction of the bottom sediments demonstrated that Cd and Zn were bound to cations/anions and carbonates loosely adsorbed on the bottom sediments in spring and summer. Such a situation was observed at all the sampling points, except for BP3 in Okradzionów. The organic carbon concentration increased along the river course.

  6. Suspended Education Department Official Had Approved Waiver for Former Employer

    Science.gov (United States)

    Basken, Paul

    2007-01-01

    Matteo Fontana, the student-aid official in the U.S. Department of Education who was suspended last month in an ethics case, issued a controversial high-stakes legal ruling in 2004 that benefited his former employer, Sallie Mae, on the day before the nation's top student lender completed its transition from a government-founded lender into a…

  7. Is it possible and necessary to control European spruce bark beetle Ips typographus (L. outbreak in the Białowieża Forest?

    Directory of Open Access Journals (Sweden)

    Hilszczański Jacek

    2017-03-01

    Full Text Available In response to the information published in ‘Forest Research Papers’ (vol. 77(4, 2016, regarding the problem of the European spruce bark beetle Ips typographus (L. in the Białowieża Forest, we present our viewpoint on this issue. The role of the European spruce bark beetle in the Białowieża Forest is discussed based on the experience gained in Europe’s forests. We present the effects of I. typographus outbreaks on forest biodiversity as well as outbreak mitigation in the context of the processes taking place in semi-natural forests.

  8. Silagem de colostro: caracterização do perfil de fermentação anaeróbia e desempenho de bezerros leiteiros

    OpenAIRE

    Lucas Silveira Ferreira

    2011-01-01

    O objetivo deste estudo foi caracterizar o perfil de fermentação anaeróbia de colostro e determinar seu valor nutritivo, assim como avaliar o desempenho de bezerros leiteiros alimentados com silagem de colostro como dieta líquida. No primeiro experimento, colostro bovino de segunda e terceira ordenhas foi fermentado em garrafas plásticas tipo PET que foram cheias e ligeiramente pressionadas antes do seu fechamento, criando assim uma condição anaeróbia. As garrafas foram armazenadas em sala es...

  9. Survey of Forest Elephants Loxodonta cyclotis (Matschie, 1900 (Mammalia: Proboscidea: Elephantidae in the Bia Conservation Area, Ghana

    Directory of Open Access Journals (Sweden)

    Emmanuel Danquah

    2014-10-01

    Full Text Available Information on elephant ranges and numbers is vital for effective conservation and management, especially in western Africa where elephant populations are small and scattered.  The Bia Conservation Area (BCA in southwestern Ghana is a priority site for the conservation of Forest Elephants in western Africa.  A dung count was conducted using a systematic segmented track line design to determine the density and distribution of the BCA elephant population.  The mean density of dung-piles was 452.15 per sq.km. and mean dung survival time was estimated to be 54.64 days (SD 2 days, leading to an estimate of 146 elephants (95% confidence interval 98-172 with a density of 0.48/km2 for the BCA. This estimate probably makes the Bia forest elephant population the largest in Ghana.  Records of BCA elephant activities were also made.  This study augments the Regional African Elephant Database and should facilitate strategic planning and management programmes.

  10. Improvement of nutritional status as assessed by multifrequency BIA during 15 weeks of refeeding in adolescent girls with anorexia nervosa.

    Science.gov (United States)

    Mika, Claudia; Herpertz-Dahlmann, Beate; Heer, Martina; Holtkamp, Kristian

    2004-11-01

    In patients with anorexia nervosa (AN), an assessment of changes in body composition and nutritional status is crucial for adequate nutritional management during refeeding therapies. Phase-sensitive multifrequency bioelectrical impedance analysis (BIA) is an inexpensive and noninvasive technique with which to determine nutritional status and body composition. We investigated 21 female adolescents with AN (initial BMI 15.5 +/- 1.1 kg/m(2)) 4 times between wk 3 and 15 of inpatient refeeding and 19 normal-weight, age-matched female controls. From wk 3 to 15, BMI, fat mass, body cell mass (BCM), total body water (TBW), intracellular water (ICW) but not extracellular mass (ECM), and extracellular water (ECW) increased significantly. Reactance (Xc), phase angle (PhA), and the ECM/BCM index as parameters of nutritional status improved significantly in patients and no longer differed from controls in wk 15, although the BMI of patients was significantly lower than those of controls. Changes in the ECM/BCM index were due to accretion of BCM, which was associated with an increase of ICW. Multifrequency phase-sensitive BIA seems to be a promising tool for the assessment of changes in nutritional status and body composition in patients with AN. An individually determined and controlled hyperenergetic diet as part of a multidimensional, interdisciplinary treatment program for eating disorders seems to quickly improve the nutritional status of AN patients.

  11. Drugs Approved for Thyroid Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...

  12. Drugs Approved for Breast Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Breast Cancer This page lists cancer drugs approved by the ... are not listed here. Drugs Approved to Prevent Breast Cancer Evista (Raloxifene Hydrochloride) Raloxifene Hydrochloride Tamoxifen Citrate Drugs ...

  13. 25 CFR 166.814 - How will the BIA determine the value of the products or property illegally used or removed?

    Science.gov (United States)

    2010-04-01

    ... the BIA determine the value of the products or property illegally used or removed? We will determine the value of the products or property illegally used or removed based upon a valuation of similar... property illegally used or removed? 166.814 Section 166.814 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF...

  14. Advanced oxidation protein products — biological marker of oxidative stress = Zaawansowane produkty utleniania białek – biologiczne markery stresu oksydacyjnego

    Directory of Open Access Journals (Sweden)

    Anna Cwynar

    2016-09-01

      ABSTRACT Advanced oxidation protein products (AOPPs are mostly derivatives of oxidatively modified albumin. The results of many experimental studies confirm intensification of oxidative modifications of proteins and an increase in concentration of advanced oxidation protein products (AOPPs in different pathological conditions, particularly those with well documented involvement of oxidative stress in their etiopathogenesis, but also those where its role is not yet well understood. Currently intensive research is carried out on the possibility of using AOPPs as useful indicators for diagnosing, prognosis and monitoring of diseases.   Keywords: advanced oxidation protein products, autoimmune disease, oxidative stress   STRESZCZENIE Zaawansowane produkty utleniania białek (AOPPs, to najczęściej pochodne zmodyfikowanej oksydacyjnie albuminy. Wyniki licznych badań doświadczalnych potwierdzają nasilenie oksydacyjnych modyfikacji białek i wzrost stężenia zaawansowanych produktów utleniania białek (AOPPs w różnych stanach patologicznych, szczególnie tych o dobrze udokumentowanym udziale stresu oksydacyjnego w ich etiopatogenezie, ale także takich, w których jego rola nie jest jeszcze dobrze poznana.. Obecnie trwają intensywne badania nad możliwością wykorzystania AOPPs, jako użytecznych wskaźników do diagnozowania, prognozowania oraz monitorowania chorób.   Słowa kluczowe: zaawansowane produkty utleniania białek, choroby autoimmunologiczne, stres oksydacyjny

  15. Poet Marion Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-North Manchester, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable

  16. Poet Portland Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves the petition, with modifications, from Poet Biorefining-Portland, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel

  17. Poet North Manchester Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-North Manchester, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable

  18. Poet Alexandria Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-Alexandria, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel

  19. Poet Laddonia Approval

    Science.gov (United States)

    This update Auugust 9, 2016 letter from EPA approves with modifications, the petition from Poet Biorefining Laddonia, Poet Laddonia Facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act f

  20. Drugs Approved for Neuroblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  1. Drugs Approved for Leukemia

    Science.gov (United States)

    This page lists cancer drugs approved by the FDA for use in leukemia. The drug names link to NCI's Cancer Drug Information summaries. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  2. Drugs Approved for Retinoblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  3. Premarket Approvals (PMA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  4. Nova proposta de teste incremental de remada na avaliação aeróbia de surfistas

    Directory of Open Access Journals (Sweden)

    Felipe Bercht CANOZZI

    2015-09-01

    Full Text Available ResumoOs objetivos desse estudo foram: 1 verificar as respostas do lactato sanguíneo e da frequência cardíaca (FC durante um protocolo de campo específico de remada no surfe; 2 correlacionar os índices de capacidade e potência aeróbia determinados nesse protocolo específico com o tempo de prática da modalidade e variáveis antropométricas. Participaram deste estudo nove sujeitos (24 ± 4,5 anos; 72,2 ± 6,7 kg; 178,4 ± 4,8 cm que foram submetidos a um teste progressivo intermitente de remada sobre a sua própria prancha de surfe, do tipo vai e vêm, com velocidades iniciais entre 1-1,1 m/s e incrementos de 0,05 m/s a cada 3 min até a exaustão voluntária. Uma resposta linear e exponencial foram observadas para a FC e o lactato sanguíneo, respectivamente, durante o protocolo incremental. Este comportamento foi semelhante ao demonstrado durante protocolos incrementais com objetivo de avaliar a capacidade e a potência aeróbia realizados em outras modalidades cíclicas. Além disso, foram encontradas correlações significantes entre o pico de velocidade (PV e a velocidade correspondente ao início do acúmulo de lactato no sangue (vOBLA (r = 0,87, p = 0,005 e do PV com tempo de prática de surfe (r = 0,70, p = 0,03. No entanto, não foram encontradas correlações significativas entre PV e vOBLA com nenhuma das variáveis antropométricas mensuradas. Assim, podemos concluir que o protocolo incremental específico de remada no surfe utilizado no presente estudo poderia ser uma ferramenta útil na determinação de índices relacionados à capacidade (vOBLA e potência (PV aeróbia de surfistas.

  5. Biodigestão anaeróbia de efluente de abatedouro avícola

    Directory of Open Access Journals (Sweden)

    Arley Borges de Morais Oliveira

    2011-12-01

    Full Text Available Objetivou-se, com este trabalho, avaliar o processo de biodigestão anaeróbia no tratamento de efluentes de abatedouro avícola, considerando-se os TRH de 7, 14 e 21 dias, além da adição de enzima lipolítica aos substratos, nas concentrações de 0; 0,5; 1,0 e 1,5 g L-1 de carga adicionada aos biodigestores. A influência dos TRH e da adição de enzima lipolítica aos substratos foi avaliada por meio das produções de biogás e CH4, dos potenciais de produção por DQO, adicionada e removida, bem como pelas reduções dos teores de DQO, concentrações de N, P e K e dos valores de pH. Os resultados obtidos demonstraram que houve influência dos TRH (em que o TRH 7 expressou os melhores resultados, para produção semanal média de biogás, com 40,7 L, e CH4, com 32,2 L e das concentrações de enzimas, com maiores valores de produção para os tratamentos 1,0 (24,6 L e 1,5 g L-1 (26,2 L, que não diferiram entre si. As concentrações de enzimas de 1,0 e 1,5 g L-1 apresentaram maiores potenciais de produção de biogás (1,1 e 1,1 L g-1 de DQO adicionada, respectivamente e metano (0,9 e 0,8 L g¹ de DQO adicionada, respectivamente, quando comparadas com as da 0,5 g L-1 (0,8 e 0,7 L g-1 biogás e CH4, respectivamente e 0 (0,7 e 0,5 L g-1 biogás e CH4, respectivamente. As maiores remoções de DQO foram alcançadas nas concentrações de 0,5 g L-1 (83,3% e TRH de 21 dias (74,4%. Contudo, para que haja maior eficiência na reciclagem energética, recomenda-se a utilização de concentrações de 1,0 g L-1 de efluente e tempo de retenção hidráulica de 7 dias.

  6. Nova proposta de teste incremental de remada na avaliação aeróbia de surfistas

    OpenAIRE

    CANOZZI, Felipe Bercht; SILVEIRA, Bruno Honorato da; OLIVEIRA, Mariana Fernandes Mendes de; CAPUTO, Fabrízio

    2015-01-01

    ResumoOs objetivos desse estudo foram: 1) verificar as respostas do lactato sanguíneo e da frequência cardíaca (FC) durante um protocolo de campo específico de remada no surfe; 2) correlacionar os índices de capacidade e potência aeróbia determinados nesse protocolo específico com o tempo de prática da modalidade e variáveis antropométricas. Participaram deste estudo nove sujeitos (24 ± 4,5 anos; 72,2 ± 6,7 kg; 178,4 ± 4,8 cm) que foram submetidos a um teste progressivo intermitente de remada...

  7. Dynamika kształtowania się struktury narodowościowej Białorusi po II wojnie światowej

    Directory of Open Access Journals (Sweden)

    Eugeniusz Mironowicz

    2017-12-01

    Full Text Available The dynamics of development of the ethnic structure of Belarus after World War II During the Second World War, Belarus lost more than 1.5 million inhabitants. In 1944–1946, as part of the repatriation process, 226,000 Poles left for Poland. With the construction industry in Belarus, deploying units of the Red Army and the creation of the Soviet system of government, to Belarus poured in hundreds of thousands of Russians and dozens of thousands of Ukrainians. At the same time, the Soviet authorities pursue policies conducive to resettlement Belarusians to other republics, especially to Russia. Widespread census was held every 10 years since 1959. It shows a systematic process of strengthening the Russian factor in the ethnic structure of the Belarusian Soviet Socialist Republic. This was accompanied by assimilation in Russian culture of the Belarusian youth, expelling from the countryside to the cities. The creation of the independent Belarusian state after the collapse of the Soviet Union reversed these trends. The percentage of people declaring Russian nationality, but also Jewish, Ukrainian and Polish, began to rapidly decline in the ethnic structure. This was accompanied, however, by a stronger presence of the Russian language, both in the public and private life of people in Belarus.   Dynamika kształtowania się struktury narodowościowej Białorusi po II wojnie światowej W czasie II wojny światowej Białoruś utraciła ponad 1,5 mln mieszkańców. W latach 1944–1946 w ramach akcji repatriacyjnej do Polski wyjechało 226 tys. Polaków. Wraz z budową przemysłu na Białorusi, rozmieszczaniem jednostek Armii Czerwonej i tworzeniem radzieckiego systemu władzy do Białorusi napływały setki tysięcy Rosjan i dziesiątki tysięcy Ukraińców. Jednocześnie władze radzieckie prowadziły politykę sprzyjającą przesiedlaniu Białorusinów do innych republik, a zwłaszcza do Rosji. Powszechne spisy ludności organizowane co 10 lat od

  8. Vedolizumab: first global approval.

    Science.gov (United States)

    Poole, Raewyn M

    2014-07-01

    Vedolizumab [Entyvio(®) (US, Europe)], a humanized monoclonal antibody α4β7 integrin receptor antagonist, has been developed by Millennium Pharmaceuticals (d/b/a Takeda Pharmaceuticals International) for the treatment of ulcerative colitis and Crohn's disease. Vedolizumab has received its first global approval for the treatment of ulcerative colitis and Crohn's disease in the US, for use in adult patients with moderate-to-severe disease who have had an inadequate response, loss of response or intolerance to one or more standard therapies (corticosteroids, immunomodulators or tumour necrosis factor-α inhibitor) or demonstrated dependence on corticosteroids. Vedolizumab has since been approved for ulcerative colitis and Crohn's disease in the EU, Norway, Iceland and Liechtenstein. This article summarizes the milestones in the development of vedolizumab leading to its first approval for the treatment of ulcerative colitis and Crohn's disease.

  9. Wykrywanie białka prionu w płynach ustrojowych – nowe perspektywy w diagnostyce choroby Creutzfeldta-Jakoba

    Directory of Open Access Journals (Sweden)

    Ewa Golańska

    2013-11-01

    Full Text Available Choroba Creutzfeldta-Jakoba (Creutzfeldt-Jakob disease, CJD należy do grupy chorób wywołanych przez priony, których diagnostyka nastręcza trudności ze względu na brak nieinwazyjnych metod umożliwiających przyżyciowe definitywne rozpoznanie. Rutynowe badania laboratoryjne wspomagające diagnostykę polegają na oznaczaniu obecności białka 14-3-3 w płynie mózgowo-rdzeniowym. Białko to jest jednak jedynie nieswoistym markerem rozpadu neuronów. Również badania obrazowe oraz EEG są niewystarczające do pewnego potwierdzenia rozpoznania. Obecnie duże nadzieje wiąże się z rozwojem czułych i swoistych metod wykrywania śladowych ilości nieprawidłowych konformerów białka PrPSc – markera jednoznacznie związanego z chorobami wywołanymi przez priony – znajdujących się w płynie mózgowo-rdzeniowym lub krwi chorych z CJD. W artykule omówiono opracowane w ostatnich latach metody, w których wykorzystuje się zdolność białka prionu do indukowania przekształcenia struktury przestrzennej cząsteczek PrPc w patologiczną izoformę PrPSc. Największe nadzieje na praktyczne zastosowanie budzi obecnie metoda konwersji indukowanej przez wytrząsanie (quaking-induced conversion, QuIC, oparta na amplifikacji nieprawidłowych konformerów białka prionu w warunkach in vitro z zastosowaniem oczyszczonego zrekombinowanego białka PrPc jako substratu. Omówiono zasadę metody, wyniki najnowszych badań nad jej optymalizacją oraz perspektywy wykorzystania w celach diagnostycznych i naukowych.

  10. CORN, LP Goldfield Approval

    Science.gov (United States)

    This November 19, 2015 letter from EPA approves the petition from CORN, LP, Goldfield facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS pro

  11. Poet Fostoria Approval

    Science.gov (United States)

    This August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-Fostoria, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6)

  12. Poet Lake Crystal Approval

    Science.gov (United States)

    This September 19, 2016 letter from EPA approves the petition from Poet Biorefining-Lake Crystal, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS

  13. Poet Leipsic Approval

    Science.gov (United States)

    This August 9, 2016 letter from EPA approves,wtih modifications, the petition from Poet Biorefining-Leipsic, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs

  14. Drugs Approved for Rhabdomyosarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for rhabdomyosarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries. There may be drugs used in rhabdomyosarcoma that are not listed here.

  15. Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

    DEFF Research Database (Denmark)

    Palle, Stine Skov; Tang Møllehave, Line; Kadkhoda, Zahra Taheri

    2016-01-01

    during the course of their treatments. Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer...... undergoing chemotherapy. Design: In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper......)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight. Results: 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were...

  16. BMI or BIA: Is Body Mass Index or Body Fat Mass a Better Predictor of Cardiovascular Risk in Overweight or Obese Children and Adolescents?

    Directory of Open Access Journals (Sweden)

    Barbara Bohn

    2015-04-01

    Full Text Available Background: Body fat (BF percentiles for German children and adolescents have recently been published. This study aims to evaluate the association between bioelectrical impedance analysis(BIA-derived BF and cardiovascular risk factors and to investigate whether BF is better suited than BMI in children and adolescents. Methods: Data of 3,327 children and adolescents (BMI > 90th percentile were included. Spearman's correlation and receiver operating characteristics (ROCs were applied determining the associations between BMI or BF and cardiovascular risk factors (hypertension, dyslipidemia, elevated liver enzymes, abnormal carbohydrate metabolism. Area under the curve (AUC was calculated to predict cardiovascular risk factors. Results: A significant association between both obesity indices and hypertension was present (all p Conclusion: BIA-derived BF was not superior to BMI to predict cardiovascular risk factors in overweight or obese children and adolescents.

  17. COMPORTAMENTO DOS SÓLIDOS TOTAIS NO PROCESSO DE DIGESTÃO ANAERÓBIA DE RESÍDUOS SÓLIDOS URBANOS E INDUSTRIAIS

    Directory of Open Access Journals (Sweden)

    Valderi Duarte Leite

    1999-08-01

    Full Text Available RESUMO O processo de digestão anaeróbia pode ser aplicado para bioestabilizar uma grande variedade de substratos. Neste trabalho, empregou-se o processo de digestão anaeróbia à fração orgânica putrescível dos resíduos sólidos urbanos, tomando-se como parâmetros avaliativos os sólidos totais e os sólidos totais voláteis. O trabalho foi realizado em quatro reatores anaeróbios de batelada, com capacidade unitária de 50 L e a análise dos seus dados mostra que é possível se empregar o processo de digestão anaeróbia a esse tipo de substrato que, além de bioestabilizar a matéria orgânica putrescível, produz gás metano, que pode ser utilizado como fonte alternativa de energia para fins domésticos e industriais.

  18. Linaclotide: first global approval.

    Science.gov (United States)

    McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate

    2012-11-12

    Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  19. Neratinib: First Global Approval.

    Science.gov (United States)

    Deeks, Emma D

    2017-10-01

    Neratinib (Nerlynx™) is an oral, irreversible inhibitor of the human epidermal growth factor receptors HER1 (EGFR), HER2 and HER4. The drug originally arose from research by Wyeth (now Pfizer) and is now being developed by Puma Biotechnology primarily for the treatment of HER2-positive (HER+) breast cancer. Neratinib is approved in the USA for the extended adjuvant treatment of patients with HER2+ early-stage breast cancer who have been previously treated with a trastuzumab-based adjuvant regimen, and is in the preregistration phase for this indication in the EU. Neratinib, as monotherapy and/or combination therapy, is also in phase 3 development for metastatic breast cancer and in phase 1/2 development for advanced breast cancer and other solid tumours, including non-small cell lung cancer, colorectal cancer and glioblastoma. This article summarizes the milestones in the development of neratinib leading to this first approval for breast cancer.

  20. Avelumab: First Global Approval.

    Science.gov (United States)

    Kim, Esther S

    2017-05-01

    Avelumab (Bavencio ® ) is an intravenously administered programmed cell death ligand-1-blocking human antibody initially developed by EMD Serono Inc. (the biopharmaceutical division of Merck KGaA, Darmstadt, Germany) [now jointly developed and commercialized by EMD Serono Inc. and Pfizer] for the treatment of various tumours. It has received accelerated approval in the USA for the treatment of metastatic Merkel cell carcinoma (mMCC) in adults and paediatric patients aged ≥12 years. The marketing authorization application for avelumab in the treatment of mMCC is undergoing regulatory review in the EU, the biologics license application for avelumab in the treatment of urothelial carcinoma is undergoing priority review by the FDA, and avelumab is in various stages of development internationally for a variety of cancers. This article summarizes the milestones in the development of avelumab leading to this first approval for mMCC.

  1. Baltic Sea coastal erosion; a case study from the Jastrzębia Góra region

    Directory of Open Access Journals (Sweden)

    Uścinowicz Grzegorz

    2014-12-01

    Full Text Available The coastline in the Jastrzębia Góra area can be divided into three major zones of general importance: a beach and barrier section, a cliff section, and a section protected by a heavy hydrotechnical construction. These areas are characterised by a diverse geology and origin, and hence different vulnerability to erosion. In addition, observations have demonstrated a different pace of erosion within each zone. Based on the results obtained by remote sensing methods (analysis of aerial photographs and maps, it has been determined that the coastline in the barrier area, i.e., to the west of Jastrzębia Góra, moved landwards by about 130 m, in a period of 100 years, and 80 m over about 50 years. A smaller displacement of the shoreline could be observed within the cliff. Between the middle of the twentieth and the start of the twenty-first centuries the shore retreated by about 25 m. However, in recent years, an active landslide has led to the displacement of the uppermost part of the cliff locally up to 25 m. Another issue is, functioning since 2000, a heavy hydrotechnical construction which has been built in order to protect the most active part of the cliff. The construction is not stable and its western part, over a distance of 50 m, has moved almost 2 m vertically downwards and c. 2.5 m horizontally towards the sea in the past two years. This illustrates that the erosional factor does not comprise only marine abrasion, but also involves land-based processes determined by geology and hydrogeology. Changes in the shoreline at the beach and barrier part are constantly conditioned by rising sea levels, the slightly sloping profile of the sea floor and low elevation values of the backshore and dune areas. Cliffs are destroyed by mass wasting and repetitive storm surges that are responsible for the removal of the colluvium which protects the coast from adverse wave effects. Presumably, mass movements combined with groundwater outflow from the cliff

  2. Cisovka - the relic population of Abies alba and its relationship to man-made silver-fir stands in Białowieża primeval forest

    Directory of Open Access Journals (Sweden)

    Leon Mejnartowicz

    2014-01-01

    Full Text Available In Białowieża Primeval Forest, in 1823 Stanisław Górski discovered on the Cisovka Hag, a relic population of European silver-fir (Abies alba Mill.. This population is isolated and most away, 120 km to the North-East, from the border of European-silver-fir distribution. Besides the natural population Cisovka, there are also man-made silver fir stands and clumps in the Polish and Belorussian part of Białowieża Primeval Forest. In the Polish part there are four such artificial stands. If the seed-producing silver-fir stands really originated from the Cisovka population, then they are a very valuable part of the declining population and an easy accessible seed source. However, if these populations were introduced to the Białowieża Primeval Forest, then they are a potential source of dangerous genetic pollution of the Cisovka population. The relationship of the genetic structure of the Cisovka population to man-made silver-fir-stands in Białowieża Forest was investigated with the help of 17 loci of 1 1 enzyme systems. Genetic diversity of Cisovka population is characterized by the smallest mean number of alleles per locus (Mal= 1.353, includes all loci studied and per polimorphic locus Malp = 2.00. In Cisovka population there is very low-grade of polimorphic loci (Pp = 11.765 with the mean 37.255 for all studied populations. Expected heterozygosity, He = 0.079 revealed very low-grade of genetic diversity in the population. The observed heterozygosity (Ho = 0.123 was similar to this characterictic in other populations. A dendrogram based on Neis genetic distance coefficient (D among 9 silver-fir populations was constructed. Cisovka in the UPGMA dendrogram is a distinct population separated from other ones by a very great genetic distance (D = 0.06. Also two man-made silver-fir (B I and 132 stands are separated from others. Only populations B3 and B4 are combined into one subgroup linked to the population Tomaszów Lubelski. Basing on the

  3. Correlation between ultrafiltration rate and phase angle measured by BIA in chronic kidney disease patients on regular hemodialysis

    Science.gov (United States)

    Nasution, B. R.; Lubis, A. R.

    2018-03-01

    Chronic Kidney Disease (CKD) patients with regular hemodialysis have high rates of morbidity and mortality that may be related to the hemodynamic effects of rapid UFR and low PhA value. In this study, we investigated whether high UFR is associated with a low value of PhA thus indirectly affect the risk of morbidity and mortality. UFR and Bioelectrical Impedance Analysis (BIA) examination on 92 subjects were recorded shortly after HD and analyzed by using Pearson correlation test. Multivariate analysis was also conducted to identify several factors that can affect the value of Phase angle. The number of HD regular CKD patients with PhA<4 based on the division of the UFR (cc/kg/h) <10, 10-13, ≥ 13, respectively were3, 10 and 6, whereas patients with ≥ 4 PhA <10, 10-13, ≥ 13respectively were 60, 11, and 2. The results showed a significant relationship between UFR with PhA. In CKD patients with regular HD, UFR has aninverse relationship with the value of PhA. After multivariate analysis, the UFR and the etiology of HD are still significantly affect the value of PhA. UFR optimal value in patients with CKD with regular HD is <10 cc/kg/h.

  4. The occurrence of parasitic arthropods in two groups of European bison in the Białowieza primeval forest.

    Science.gov (United States)

    Izdebska, J N

    2001-01-01

    Within 1992-2000, a total of 181 Białowieza Forest bison were examined from two winter herds. Twelf parasitic arthropod species were observed, a high infestation being typical of Demodex bisonianius, Chorioptes bovis, Ixodes ricinus, Dermacentor reticulatus, and Bisonicola sedecimdecembrii. The infestation in section 422 herd being higher for B. sedecimdecembrii, I. ricinus, D. reticulatus, Ch. bovis. D. bisonianus was slightly more prevalent in the section 391 herd, the intensity being, however, lower than that in the other herd. Among the remaining arthropods found in the Bialowieza Forest European bison, some Lipoptena cervi occurred in both herds, Demodex sp. and Sarcoptes scabiei were recorded only in the section 422 herd, Ixodes persulcatus was present only in the section 391 bison and those kept in the reservation, while D. bovis, Psoroptes ovis, and Melophagus ovinus were found in the reserve bison only. In the present study, the largest differences in the extent of infestation involved the hair-dwelling arthropods (B. sedecimdecembrii, I. rixinus).

  5. Supercollider: Footprint approved

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    With the 'footprint' - the precise location of the 87-kilometre US Superconducting Supercollider, SSC, and its ancillary buildings - now approved, teams of specialists commissioned by the State of Texas swing into action to procure the 17,000 acres (69 million square metres) of land covered by the project. With the SSC Laboratory in Ellis County and the US Department of Energy (DoE, the overseeing government agency) both hiring manpower for this project to collide 20 TeV (20,000 GeV) proton beams before the end of the century, the host State of Texas is providing a helping hand

  6. The Evolution of Approval Services.

    Science.gov (United States)

    Warzala, Martin

    1994-01-01

    Describes major developments in book approval plans used by academic libraries for acquisition and for information dissemination and document distribution services based on approval-like concepts. Topics addressed include publishers; marketing; the impact of library automation; value-added services; the economic climate; the influence of…

  7. Electronic Approval of Invoices (AEF)

    CERN Document Server

    2004-01-01

    With a view to the simplification of administrative procedures, AS and FI Departments have completed the second phase of the new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. Phase II includes handling the electronic approval process of invoices whose amounts do not correspond exactly to those of the associated orders. In such cases, budgetary approval is required for the entire invoiced amount. Further information can be obtained at : http://ais.cern.ch/projs/AEF/help/F_help.htm Phase II of the procedure will be introduced gradually with effect from April 2004. Finance Department, Accounts Payable Section Tel: 72295 Organisation and Procedures Tel: 75885 Information Technologies Department,...

  8. Biosimilars approval process.

    Science.gov (United States)

    Zuñiga, Leyre; Calvo, Begoña

    2010-04-01

    For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological product, does not meet the conditions in the definition of generic medicinal products the results of appropriate pre-clinical tests or clinical trials relating to these conditions must be provided. The challenge is to determine the exact nature of the non-clinical and clinical programme required to gain regulatory approval. The applicant is encouraged to provide a detailed description of the strategy used to demonstrate the biosimilar and the reference product have similar profiles in terms of quality, safety and efficacy. The extent to which comparability can be proven will have quite an impact on how many non-clinical and clinical studies the biosimilar applicant will be required to conduct. The dossier submitted by the applicant to the EMEA should cover all aspects of the comparability assessment and must include data on possible unwanted immune reactions to the therapeutic protein. Post-marketing pharmacovigilance plans are also expected to be included in the biosimilar dossier. Copyright 2009 Elsevier Inc. All rights reserved.

  9. Drugs Approved for Kidney (Renal Cell) Cancer

    Science.gov (United States)

    ... Your Treatment Research Drugs Approved for Kidney (Renal Cell) Cancer This page lists cancer drugs approved by the ... not listed here. Drugs Approved for Kidney (Renal Cell) Cancer Afinitor (Everolimus) Aldesleukin Avastin (Bevacizumab) Axitinib Bevacizumab Cabometyx ( ...

  10. BMI or BIA: Is Body Mass Index or Body Fat Mass a Better Predictor of Cardiovascular Risk in Overweight or Obese Children and Adolescents?

    Science.gov (United States)

    Bohn, Barbara; Müller, Manfred James; Simic-Schleicher, Gunter; Kiess, Wieland; Siegfried, Wolfgang; Oelert, Monika; Tuschy, Sabine; Berghem, Stefan; Holl, Reinhard W.

    2015-01-01

    Background Body fat (BF) percentiles for German children and adolescents have recently been published. This study aims to evaluate the association between bioelectrical impedance analysis(BIA)-derived BF and cardiovascular risk factors and to investigate whether BF is better suited than BMI in children and adolescents. Methods Data of 3,327 children and adolescents (BMI > 90th percentile) were included. Spearman's correlation and receiver operating characteristics (ROCs) were applied determining the associations between BMI or BF and cardiovascular risk factors (hypertension, dyslipidemia, elevated liver enzymes, abnormal carbohydrate metabolism). Area under the curve (AUC) was calculated to predict cardiovascular risk factors. Results A significant association between both obesity indices and hypertension was present (all p correlation with BMI was stronger (r = 0.22) compared to BF (r = 0.13). There were no differences between BMI and BF regarding their correlation with other cardiovascular risk factors. BF significantly predicted hypertension (AUC = 0.61), decreased HDL-cholesterol (AUC = 0.58), elevated LDL-cholesterol (AUC = 0.59), elevated liver enzymes (AUC = 0.61) (all p < 0.0001), and elevated triglycerides (AUC = 0.57, p < 0.05), but not abnormal carbohydrate metabolism (AUC = 0.54, p = 0.15). For the prediction of cardiovascular risk factors, no significant differences between BMI and BF were observed. Conclusion BIA-derived BF was not superior to BMI to predict cardiovascular risk factors in overweight or obese children and adolescents. PMID:26087841

  11. Approval plans issues and innovations

    CERN Document Server

    Katz, Linda S

    2013-01-01

    How can you, as an acquisition librarians, keep current on the output of hundreds of publishers? The answer, of course, is that you cannot. For over 30 years, approval plans have been used by librarians to acquire current titles, save staff time, and build core collections. Even today, these reasons seem appropriate, as libraries try to maintain up-to-date collections and control personnel and operating budgets. However, as shown in Approval Plans: Issues and Innovations, the use of approval plans is not so simple and straightforward; their use is subject to complex procedures and policies--an

  12. 48 CFR 750.7105 - Approving authorities.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS Extraordinary Contractual Actions To Protect Foreign Policy Interests of the United States 750.7105 Approving authorities. All authority to approve actions...

  13. Drugs Approved for Esophageal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for esophageal cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  14. Drugs Approved for Liver Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for liver cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  15. Drugs Approved for Kaposi Sarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Kaposi sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  16. Drugs Approved for Pancreatic Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for pancreatic cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  17. Drugs Approved for Vaginal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) to prevent vaginal cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  18. Drugs Approved for Skin Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  19. Drugs Approved for Vulvar Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for vulvar cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  20. Drugs Approved for Wilms Tumor

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Wilms tumor and other childhood kidney cancers. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  1. Drugs Approved for Lung Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for lung cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  2. Drugs Approved for Bone Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bone cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  3. Drugs Approved for Malignant Mesothelioma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  4. Drugs Approved for Penile Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for penile cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  5. Drugs Approved for Bladder Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  6. Drugs Approved for Endometrial Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for endometrial cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  7. Is It Really FDA Approved?

    Science.gov (United States)

    ... satisfaction before companies can market them in interstate commerce. Some examples of biologics that require approval are ... it means the agency has determined that the benefits of the product outweigh the known risks for ...

  8. Electronic Voucher Approval - Financial Management

    Data.gov (United States)

    US Agency for International Development — This process provides a workflow and eSignature capability which allows the CFO to router vouchers for review and electronic signature approval to COTRs in AIDW. It...

  9. Los dueños del dinero. Prestamistas abulenses a mediados del siglo XV = The Masters of Money. Money-Lenders in Mid-Fifteenth-Century Ávila

    Directory of Open Access Journals (Sweden)

    Octavio Colombo

    2016-06-01

    Full Text Available El objetivo del presente trabajo es reconstruir el perfil socioeconómico de los prestamistas abulenses que aparecen en el libro del notario Gómez González entre los años 1448 a 1451. Allí consta la existencia de unas setecientas operaciones de préstamo, de las cuales más de la mitad tienen como acreedores a un pequeño número de sujetos. A su vez, los mismos aparecen involucrados en numerosas actividades económicas adicionales. Se realiza en primer lugar una presentación del conjunto de las deudas consignadas, su distribución temporal, sus montos y de las características globales de prestamistas y prestatarios. Luego, se analizan las actividades de los acreedores más prominentes, utilizando para ello documentación complementaria del concejo de Ávila. En base a ello, por último, se intenta una reconstrucción del perfil social de este segmento de la sociedad concejil bajomedieval. The objective of this paper is to reconstruct the socio-economic profile of money-lenders in Ávila which appear in the books of the public notary, Gómez González, between 1448 and 1451. From this source, it is possible to identify close to seven hundred credit records, of which more than half belong to a small group of lenders. Furthermore, these creditors also appear taking part in many additional economic activities. First, we present a comprehensive examination of these loans, their chronological distribution, the monetary quantities and the general features of the lenders and the borrowers. Secondly, we analyze the activities of the most prominent lenders using supplementary documents from Ávila. Finally and based on this collected data, we intend to reconstruct the social profile of this group within late-medieval urban society.

  10. Białoruskie elementy językowe w rosyjskiej gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim

    Directory of Open Access Journals (Sweden)

    Dorota Angelika Paśko-Koneczniak

    2014-12-01

    Full Text Available Elements of the Belarusian language in the Russian dialect used by the Old Believers living in the Suwałki-Augustów region The article deals with the Belarusian elements in the Russian dialect of the Old Believers living in Poland. The Old Believers arrived in Poland in the second half of the 18th century. At present they live in the Suwałki-Augustów region in the north-eastern Poland. They inhabit mostly two villages in the county of Suwałki, namely Gabowe Grądy and Bór, which are very close to each other, and three towns: Augustów, Suwałki and Sejny. The dialect used by the Polish Old Believers represents the western Central Great Russian dialects characterized by akanie, the so-called Pskov group. They share features which are typical of Pskov. The dialect was also influenced by other north-eastern Belarusian dialects, that is, the ones which were closest to the areas originally inhabited by Old Believers, who migrated in phases. After each phase, their dialect came to reflect some new linguistic influences. A large number of lexemes directly borrowed from Polish, or via the Belarusian language, are found in this dialect, which is also characterized by other features common in Belarusian dialects or the Bulgarian language. By way of illustration, they include the following features: the prosthetic j-, prosthetic v-, the occurrence of the endings –im and –ym in the case of singular masculine adjectives in the locative, promotion of the endings –i and –y in the case of the plural masculine and neutral nouns in the nominative, and the occurrence of lexemes borrowed from the Belarusian language.   Białoruskie elementy językowe w rosyjskiej gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim Artykuł poświęcony jest problematyce białoruskich elementów językowych w rosyjskiej gwarze staroobrzędowców mieszkających w Polsce. Staroobrzędowcy pojawili się na terytorium Polski w drugiej połowie XVIII

  11. „Silę ucho”, czyli co słychać w przekładzie. Niemieckojęzyczne warianty wiersza Skakanka ufoistki Mirona Białoszewskiego na tle zabiegów „przekładania” codzienności na język poetycki

    Directory of Open Access Journals (Sweden)

    Aleksandra Burba

    2014-01-01

    Full Text Available The article has been derived from a chapter of an MA thesis on everyday speech in Miron Białoszewski’s work. The text focuses on exposition of methodological assumptions - the notion of everyday speech and its translation into poetic language in Białoszewski’s works. In particular, the article discusses a series of non-professional translations of the poem UFO agent’s skipping rope into German, as an example of the functioning of the dominant of everyday speech in translations of Białoszewski’s poetry.

  12. 77 FR 57104 - Notice of Submission of Proposed Information Collection to OMB; Loan Guarantees for Indian Housing

    Science.gov (United States)

    2012-09-17

    ... service areas. Mortgage lenders approved by HUD provide borrower and lender information to HUD for..., Fannie Mae Form 1005. Description of the Need for the Information and Its Proposed Use The information is... service areas. Mortgage lenders approved by HUD provide borrower and lender information to HUD for...

  13. Habitat Preferences of Boros schneideri (Coleoptera: Boridae) in the Natural Tree Stands of the Białowieża Forest

    Science.gov (United States)

    Gutowski, Jerzy M.; Sućko, Krzysztof; Zub, Karol; Bohdan, Adam

    2014-01-01

    Abstract We analyzed habitat requirements of Boros schneideri (Panzer, 1796) (Coleoptera: Boridae) in the natural forests of the continental biogeographical region, using data collected in the Białowieża Forest. This species has been found on the six host trees, but it preferred dead, standing pine trees, characterized by large diameter, moderately moist and moist phloem but avoided trees in sunny locations. It occurred mostly in mesic and wet coniferous forests. This species demonstrated preferences for old tree stands (over 140-yr old), and its occurrence in younger tree-stand age classes (minimum 31–40-yr old) was not significantly different from random distribution. B. schneideri occupied more frequently locations distant from the forest edge, which were less affected by logging. Considering habitat requirements, character of occurrence, and decreasing number of occupied locations in the whole range of distribution, this species can be treated as relict of primeval forests. PMID:25527586

  14. A guerra como instrumento do poder presidencial nos EUA: o caso da intervenção na Líbia

    Directory of Open Access Journals (Sweden)

    Cláudio Júnior Damin

    2012-08-01

    Full Text Available Analisa-se a decisão da participação dos EUA na intervenção militar na Líbia em 2011. O objetivo central é posicionar a decisão de Barack Obama de utilizar as forças armadas como um exercício dos poderes de guerra do presidente enquanto comandante-em-chefe e como executor de deliberações de órgãos multilaterais internacionais.   We analyze the decision of U.S. participation in military intervention in Libya (2011. The main objective is to position Barack Obama's decision to use the military as an exercise of war powers of the president as commander in chief and as a doer of the deliberations of international multilateral agencies.

  15. [Professional dysphonia and its risk factors in the material of the outpatient clinic of the Department of Otolaryngology, Medical Academy of Białystok].

    Science.gov (United States)

    Kosztyła-Hojna, Bozena; Rogowski, Marek; Ruczaj, Jan; Pepiński, Witold

    2004-01-01

    Occurrence of professional dysphonia was analysed in a group of 309 patients treated in the Phoniatric Outpatient Clinic, Department of Otolaryngology, Medical Academy in Białystok through the period of 1999-2001. In a group of professional voice users female teachers of primary schools and lower secondary schools predominated. Obtained results were compared with those from a group of 65 persons of other occupations. In the both groups other harmful factors affecting the voice organ were excluded. The clinical assessment included subjective and objective laryngological examination using videolaryngostroboscopy. The clinical material was evaluated in a view of functional and organic disorders of the voice organ. Early occurrence and aggravation of functional changes in the larynx was recorded in non professional voice users in the course of their seniority. In professional patients organic changes were more common and occurred earlier than functional disorders. Severity of dysphonia was related to the larynx pathology, especially of a functional character.

  16. Modernization Of Public Space Floor And Its Impact On Area - The Example Of The Kościuszko Square In Białystok

    Directory of Open Access Journals (Sweden)

    Tofiluk Anna

    2015-12-01

    Full Text Available The last 25 years have been in many Polish cities a period of intensive modernization and renewals of the existing public spaces. Most of all the resurfacing of the pavement and changing of street furniture have been held. In many cases, the transformations in the urban areas were integrated with exclusion from traffic. The question arises what criteria architects or landscape architects follow and what design solutions apply. It is also interesting how the new shape of the floor in public spaces (understood here as a pavement and street furniture together can help to create integrating and activating space for residents. And how it can affect the quality of life in a wider area. This article attempts to answer these questions based on new solutions on Kosciuszko Square in Białystok, executed in 2005-2009.

  17. Estudo da degradação anaeróbia do efluente de indústrias de mobiliário

    OpenAIRE

    Caramelo, Marta Sofia Almeida

    2012-01-01

    O objeto deste trabalho está relacionado com a dependência atual de combustíveis fósseis para a produção de plástico e com as crescentes preocupações ambientais relativas à sua deposição no meio ambiente, pois são um material de difícil degradação. Estes problemas associados aos plásticos, têm resultado na investigação e desenvolvimento de materiais biopoliméricos que são de fácil biodegradação. Então este trabalho tem como objetivo principal, estudar a aplicabilidade da digestão anaeróbia...

  18. Moist air state above counterflow wet-cooling tower fill based on Merkel, generalised Merkel and Klimanek & Białecky models

    Science.gov (United States)

    Hyhlík, Tomáš

    2017-09-01

    The article deals with an evaluation of moist air state above counterflow wet-cooling tower fill. The results based on Klimanek & Białecky model are compared with results of Merkel model and generalised Merkel model. Based on the numerical simulation it is shown that temperature is predicted correctly by using generalised Merkel model in the case of saturated or super-saturated air above the fill, but the temperature is underpredicted in the case of unsaturated moist air above the fill. The classical Merkel model always under predicts temperature above the fill. The density of moist air above the fill, which is calculated using generalised Merkel model, is strongly over predicted in the case of unsaturated moist air above the fill.

  19. Electronic Approval of Invoices (AEF)

    CERN Multimedia

    2003-01-01

    With a view to the simplification of administrative procedures, AS and FI Divisions have drawn up a new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. This new procedure, in its current phase, will be gradually implemented from 1 November 2003 onwards. For clarification and further information, please see: http://ais.cern.ch/projs/AEF/help/help.htm . Finance Division, Accounts Payable Tel.: 7.22.95

  20. A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold.

    Directory of Open Access Journals (Sweden)

    Marion Dalmasso

    Full Text Available Propionibacterium freudenreichii is used as a ripening culture in Swiss cheese manufacture. It grows when cheeses are ripened in a warm room (about 24°C. Cheeses with an acceptable eye formation level are transferred to a cold room (about 4°C, inducing a marked slowdown of propionic fermentation, but P. freudenreichii remains active in the cold. To investigate the P. freudenreichii strategies of adaptation and survival in the cold, we performed the first global gene expression profile for this species. The time-course transcriptomic response of P. freudenreichii CIRM-BIA1(T strain was analyzed at five times of incubation, during growth at 30°C then for 9 days at 4°C, under conditions preventing nutrient starvation. Gene expression was also confirmed by RT-qPCR for 28 genes. In addition, proteomic experiments were carried out and the main metabolites were quantified. Microarray analysis revealed that 565 genes (25% of the protein-coding sequences of P. freudenreichii genome were differentially expressed during transition from 30°C to 4°C (P1. At 4°C, a general slowing down was observed for genes implicated in the cell machinery. On the contrary, P. freudenreichii CIRM-BIA1(T strain over-expressed genes involved in lactate, alanine and serine conversion to pyruvate, in gluconeogenesis, and in glycogen synthesis. Interestingly, the expression of different genes involved in the formation of important cheese flavor compounds, remained unchanged at 4°C. This could explain the contribution of P. freudenreichii to cheese ripening even in the cold. In conclusion, P. freudenreichii remains metabolically active at 4°C and induces pathways to maintain its long-term survival.

  1. Participation and Protected Areas Governance: the Impact of Changing Influence of Local Authorities on the Conservation of the Białowieża Primeval Forest, Poland

    Directory of Open Access Journals (Sweden)

    Krzysztof Niedziałkowski

    2012-03-01

    Full Text Available According to the new conservation paradigm, protected areas should contribute to the socioeconomic development of host communities, and the latter ought to be included in participatory decision making concerning these areas. However, the understanding of participation is ambiguous and there are at least three major approaches, which may have different impacts on the governance of protected areas. We examine the case of the Białowieża Primeval Forest in order to trace the effectiveness of changing modes of participation as well as to discuss the limitations and problems of public participation. Between 1918 and 2010, the role of local authorities changed from no influence to limited control over decision making regarding designation and enlargement of the Białowieża National Park (BNP. As a result of these changes, attempts to enlarge the BNP over the whole forest were undermined. The evidence shows that power relations and instrumental reasons constituted the main drivers of the changing participation pattern with deliberative rationale lacking. As a result, the conservation goals were only partially achieved. We argue that when interests are clearly conflicting and win-win solutions are difficult to reach, room for constructive participation may be limited. In these circumstances, public involvement may turn into yet another venue for a power play between actors with vested interests, without bringing gains in legitimacy or new policy options. This is especially the case for countries with a relatively short democratic record where the government lacks the consistency and capacity to steer the process over the longer term.

  2. Drugs Approved for Cervical Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for cervical cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  3. Drugs Approved for Multiple Myeloma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  4. Drugs Approved for Testicular Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for testicular cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  5. Drugs Approved for Hodgkin Lymphoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  6. Drugs Approved for Myeloproliferative Neoplasms

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for myeloproliferative neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  7. Immunotherapy Combination Approved for Advanced Kidney Cancer

    Science.gov (United States)

    FDA has approved the combination of the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy) as an initial treatment for some patients with advanced kidney cancer. The approval is expected to immediately affect patient care, as this Cancer Currents post explains.

  8. Comparação da produção de biogás a partir da digestão anaeróbia de diferentes tipos de lodo

    OpenAIRE

    Jayna Pessuto Silva; Daniele Perondi; Danielle Restelatto; Marcelo Godinho; Aline Dettmer

    2016-01-01

    Neste trabalho foi avaliada a produção de biogás a partir da digestão anaeróbia (DA) de resíduos de arroz (utilizado para cultivo de fungos) e couro curtido ao cromo (RCCC) (inóculos). Adicionaram-se a estes, lodos de estação de tratamento de efluentes, provenientes de um curtume (LC) e de uma universidade (LU). A digestão anaeróbia gera biogás, rico em metano, e pode ser uma alternativa para o tratamento de resíduos. O objetivo deste estudo foi avaliar o volume e a fração molar do biogás ger...

  9. 40 CFR 145.31 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Approval process. 145.31 Section 145.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Program Approval, Revision and Withdrawal § 145.31 Approval process. (a...

  10. 40 CFR 123.61 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Approval process. 123.61 Section 123... REQUIREMENTS Program Approval, Revision, and Withdrawal § 123.61 Approval process. (a) After determining that a...; and (6) Briefly outline the fundamental aspects of the State's proposed program, and the process for...

  11. 7 CFR 1710.406 - Loan approval.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Loan approval. 1710.406 Section 1710.406 Agriculture... GENERAL AND PRE-LOAN POLICIES AND PROCEDURES COMMON TO ELECTRIC LOANS AND GUARANTEES Application Requirements and Procedures for Loans § 1710.406 Loan approval. (a) A loan is approved when the Administrator...

  12. 40 CFR 52.1772 - Approval status.

    Science.gov (United States)

    2010-07-01

    ...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) North Carolina § 52.1772 Approval status. (a) With the exceptions set forth in this subpart, the Administrator approves North Carolina's plans for... CTGs issued by the previous January. (b) New Source review permits issued pursuant to section 173 of...

  13. 40 CFR 52.2122 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... sources covered by CTGs issued by the previous January. (b) EPA disapproved South Carolina's generic...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) South Carolina § 52.2122 Approval status. (a) With the exceptions set forth in this subpart, the Administrator approves South Carolina's plans for...

  14. 40 CFR 52.1323 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... on January 16, 1979 (44 FR 3274) are met. (b) The Administrator approves Rule 10 CSR 10-2.290 as.... (c) The Administrator approves Rule 10 CSR 10-2.230 as identified under § 52.1320, paragraph (c)(70... SIP would be the emission limits stated in the rule. (d) The Administrator approves Rule 10 CSR 10-5...

  15. 9 CFR 147.52 - Approved tests.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Approved tests. 147.52 Section 147.52 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Approved Tests § 147.52 Approved tests. (a) The procedures for the bacteriological examination of poultry...

  16. 38 CFR 17.65 - Approvals and provisional approvals of community residential care facilities.

    Science.gov (United States)

    2010-07-01

    ... approvals of community residential care facilities. 17.65 Section 17.65 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Community Residential Care § 17.65 Approvals and provisional approvals of community residential care facilities. (a) An approval of a facility meeting all of...

  17. DETERMINAÇÃO RÁPIDA E SIMPLES DE CITRATO DE SILDENAFILA (VIAGRA® E GENÉRICOS EMPREGANDO ELETRODO IMPRESSO DE CARBONO EM SISTEMAS FIA E BIA COM DETECÇÃO AMPEROMÉTRICA

    Directory of Open Access Journals (Sweden)

    Rafael S. Backes

    Full Text Available This work presents two amperometric methods for Sildenafil Citrate (SC determination in erectile dysfunction drugs (Viagra® and Generics, using Batch Injection Analysis (BIA and Flow Injection Analysis (FIA systems with a cell for Screen Printed Electrodes (SPE. In Britton- Robinson buffer solution (pH 2, the SC presented an irreversible anodic peak at around +1.0 V vs. Ag pseudo-reference electrode, using five different working electrodes of commercial SPE. The carbon SPE (unmodified was selected as the best working electrode, providing good sensitivity, precision and low-cost. The SC amperometric detection for two proposed methods was performed at +1.1 V. The best conditions for SC determination by hydrodynamic systems were obtained through injection volumes of 50 and 150 µL at flow rates of 100 and 75 µL s-1, for BIA and FIA respectively. In these conditions, BIA system showed the best sensitivity (0.188 µA mol-1 L and theoretical analytical frequency (360 h-1 for SC determination. The repeatability studies were similar for both systems with relative standard deviation of approximately 3.0%. The SC analyses in pharmaceutical samples obtained by two proposed methods were compared to HPLC-UV method.

  18. Lessons from Białowieża Forest on the history of protection and the world's first reintroduction of a large carnivore.

    Science.gov (United States)

    Samojlik, Tomasz; Selva, Nuria; Daszkiewicz, Piotr; Fedotova, Anastasia; Wajrak, Adam; Kuijper, Dries Pieter Jan

    2018-02-01

    Understanding how the relationships between large carnivores and humans have evolved and have been managed through centuries can provide relevant insights for wildlife conservation. The management history of many large carnivores has followed a similar pattern, from game reserved for nobility, to persecuted pests, to conservation targets. We reconstructed the history of brown bear (Ursus arctos) management in Białowieża Forest (Poland and Belarus) based on a detailed survey of historical literature and Russian archives. From the end of the Middle Ages to the end of 18th century, the brown bear was considered "animalia superiora" (i.e., game exclusively reserved for nobility and protected by law). Bears, also a source of public entertainment, were not regarded as a threat. Effective measures to prevent damages to traditional forest beekeeping were already in practice. In the beginning of 19th century, new game-management approaches allowed most forest officials to hunt bears, which became the primary target of hunters due to their valuable pelt. This, together with an effective anticarnivore policy enhanced by bounties, led to bear extirpation in 1879. Different approaches to scientific game management appeared (planned extermination of predators and hunting levels that would maintain stable populations), as did the first initiatives to protect bears from cruel treatment in captivity. Bear reintroduction in Białowieża Forest began in 1937 and represented the world's first reintroduction of a large carnivore motivated by conservation goals. The outbreak of World War II spoiled what might have been a successful project; reproduction in the wild was documented for 8 years and bear presence for 13. Soft release of cubs born in captivity inside the forest but freely roaming with minimal human contact proved successful. Release of captive human-habituated bears, feeding of these bears, and a lack of involvement of local communities were weaknesses of the project

  19. 30 CFR 14.7 - Approval marking and distribution records.

    Science.gov (United States)

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.7 Approval marking and distribution records. (a) An approved conveyor belt must be marketed only under the name specified in the approval. (b) Approved conveyor belt must be legibly and...

  20. Approval of radioactive consumer goods

    International Nuclear Information System (INIS)

    Paynter, R.A.

    1992-01-01

    The 1980 Euratom Directive obliges the UK to draw up a system of prior authorization for the use of radioactive substances in a range of consumer products, and the Government intends to make regulations to fulfil the requirements of the Directive. These regulations will empower NRPB to approve such products prior to their supply to the public. In this brief article, the NRPB reviews the criteria against which to consider any proposed use of radioactive substances, considers radiological production standards for products and discusses the questions of the labelling of radioactive consumer goods. (UK)

  1. Trastuzumab emtansine: first global approval.

    Science.gov (United States)

    Ballantyne, Anita; Dhillon, Sohita

    2013-05-01

    Genentech and ImmunoGen are collaborating on the development of trastuzumab emtansine, a HER2 antibody-drug conjugate that comprises Genentech's trastuzumab antibody linked to ImmunoGen's anti-mitotic agent, mertansine (a maytansine derivative; also known as DM1). The conjugate combines two strategies: the anti-HER2 activity of trastuzumab, and the targeted intracellular delivery of mertansine, a tubulin polymerisation inhibitor which interferes with mitosis and promotes apoptosis. The linker in trastuzumab emtansine is a non-reducible thioether linker, N-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC, designated MCC after conjugation). Trastuzumab emtansine (Kadcyla™) has been launched in the USA as second-line monotherapy for HER2-positive metastatic breast cancer, and has been filed for approval in the EU and Japan in this indication. Trastuzumab emtansine is in phase III development as first-line combination therapy or monotherapy for metastatic HER2-positive breast cancer, and as third-line monotherapy for metastatic HER2-positive breast cancer. Phase II development is underway for early-stage breast cancer and phase II/III development is underway in patients with HER2-positive gastric cancer. This article summarizes the milestones in the development of trastuzumab emtansine leading to this first approval for the treatment of patients with HER2-positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination.

  2. 7 CFR 1735.90 - Preliminary approvals.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Requirements for... franchises, licenses, and permits; (4) All required regulatory body approvals; (5) All required corporate...

  3. Marketing Approval of Ethical Kampo Medicines.

    Science.gov (United States)

    Hakamatsuka, Takashi

    2017-01-01

    Kampo medicine is an original traditional medicine in Japan. Currently, 148 ethical Kampo formulations (Kampo prescription drugs) are registered in the National Health Insurance Price List. Kampo medicines can be prescribed under the national insurance system, which shows that they are part of conventional medicine in Japan. Japan has a unified drug approval system that does not distinguish between Western and Kampo medicines, and both are subject to the same regulations. The application for the market approval of ethical Kampo medicines is based on the general notification for drugs, i.e., "Handling of Ethical Combination Drugs" in "Precautions Necessary When Applying for Drug Marketing Approval" (Yakushokushinsa Notification No. 1121-12 of November 21, 2014). Furthermore, applications for the market approval of ethical Kampo medicines should follow the Kampo-specific notification of "Handling of Ethical Kampo Medicines" (Yakushin Notification No. 804 of June 25, 1980). Data from comparative studies with standard decoctions must be submitted with approval applications according to Yakushin 2 Notification No. 120 of May 31, 1985. The safety, efficacy, and quality of Kampo medicines are comprehensively assured by the Japanese Pharmacopoeia, Good Manufacturing Practice, Good Agricultural and Collection Practices, marketing approval certificate, approval standard, and pharmacovigilance. I believe that the basic framework for the market approval of ethical Kampo medicines has been established as described above. The key factors for the practical application of superior manufacturing technology and research achievements and the promotion of drug development are the specific guidelines for the approval of drugs of herbal origin.

  4. OMB Recommended vs Approved Operating Budget

    Data.gov (United States)

    Montgomery County of Maryland — This dataset includes the Fiscal Year 2015 County Executive Recommended and County Council Approved operating budgets for Montgomery County, for comparison purposes....

  5. MNR Approvals for waterpower projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    On May 5, 2011, the Ontario Waterpower Association hosted the emergent hydro workshop in Peterborough. In the course of the workshop, the Ministry of Natural Resources (MNR) presented the different requirements for approval of waterpower projects. Various legislation administered by MNR applies to waterpower projects: the Public Lands Act, the Lakes and Rivers Improvement Act, the Endangered Species Act, 2007, and other legislation. The Public Lands Act provides policy and procedure for water power site release; the Lakes and Rivers Improvement Act was designed to manage, protect and preserve waters, land, fish, wildlife and other natural resources; the Endangered Species Act, 2007, is intended to protect species from extinction by protecting their habitats and promoting their recovery. MNR also administer other legislation, including the Aggregate Resources Act and the Forest Fires Prevention Act. This presentation provided an overview of the various pieces of legislation regulating waterpower projects which are administered by MNR.

  6. Polypharmacology of Approved Anticancer Drugs.

    Science.gov (United States)

    Amelio, Ivano; Lisitsa, Andrey; Knight, Richard A; Melino, Gerry; Antonov, Alexey V

    2017-01-01

    The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. Authority approvals and environmental investigations

    International Nuclear Information System (INIS)

    Olsen, F.A.; Svenson, J.

    1999-01-01

    The possible sites have been reviewed environmentally and approved in principle by the Danish authorities through 'The Offshore Wind Turbine Committee'. Therefore, environmental studies were not expected to form par of this study. However, the contacts to the authorities revealed a need for further investigations. A required Environmental Impact Study shall be performed in accordance with EC directive of June 27 1985 and March 3 1997, and more specific requirements from the Danish authorities. The possible visual impacts of the proposed large scale offshore project at Roedsand proved to be a major issue for the local acceptance of the projects. Therefore, computer aided visualisations of selected views of all 3 projects were performed and presented to the public. The visualisations were performed with dedicated computer programmes and are presented on colour photos seen from land, sea and air. As a conclusion, the possible visual impact of the proposed projects are not found to be prohibitive for a realisation of the proposed projects. (LN)

  8. The transport system approval concept

    International Nuclear Information System (INIS)

    Pettersson, B.G.

    1991-01-01

    The needs for, and merits of, a new concept for the safety assessment and approval of shipments of radioactive materials is introduced and discussed. The purpose of the new concept is to enable and encourage integration of analysis and review of transport safety with similar safety analysis and review of the handling operations involving the radioactive material at the despatching and receiving ends of a shipment. Safety contributing elements or functions of the means of transport (the Transport System) can thus readily be taken into account in the assessment. The objective is to avoid constraints -experienced or potential - introduced by the package functional provisions contained in the transport regulations, whilst maintaining safety during transport, as well as during facility handling operations, at least at the level at the level currently established. (author)

  9. 19 CFR 115.41 - Certificate of approval for containers approved after manufacture.

    Science.gov (United States)

    2010-04-01

    ... after manufacture. 115.41 Section 115.41 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT... PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers After Manufacture § 115.41 Certificate of approval for containers approved after manufacture. The Certifying Authority shall...

  10. Post-Mortem Evaluation of Pathological Lesions in European Bison (Bison Bonasus in the Białowieża Primeval Forest Between 2008 and 2013

    Directory of Open Access Journals (Sweden)

    K. Krzysiak Michał

    2014-10-01

    Full Text Available The study presents the analysis of the findings of 234 post-mortem examinations on free-ranging and captive European bison selectively culled or having fallen between 2008 and 2013 in Białowieża Primeval Forest. Pneumonia, emphysema, nephritis, bodily traumas, and intestinal lesions were observed in 106 (45.3%, 77 (32.9%, 82 (35.0%, 68 (29.1%, and 56 (23.9% animals respectively and were the most common pathological changes. Almost half of all males (66 out of 140; 47.1% tested showed some pathological changes of prepuce and penis, described as posthitis or balanoposthitis. Infection with liver fluke (Fasciola hepatica and lungworm (Dictyocaulus viviparus was observed macroscopically in 114 (48.7% and 80 (32.9% bison respectively. F. hepatica prevalence was associated with the emergence of other liver changes such as hepatitis and cirrhosis (P < 0.001. Similarly, the prevalence of D. viviparus coincided with pneumonia (P = 0.001, changes in the upper respiratory tract (P = 0.04, and emphysema (P < 0.001. Hepatitis, infection with F. hepatica, and pathological lesions in the male and female reproductive tracts were associated with the animals’ age. Mechanical injuries, caused by other bison or less commonly by traffic accidents, were the most common cause of death of bison below six months of age. Most pathological changes were significantly more frequent in the selectively culled animals in comparison with the ones having fallen, which confirms the desirability of elimination as a tool to improve the health and welfare of the bison population and limit the number of reservoirs of invasive and possibly infectious diseases.

  11. Biodigestão anaeróbia de dejetos de bovinos leiteiros submetidos a diferentes tempos de retenção hidráulica

    Directory of Open Access Journals (Sweden)

    Amaral Cecília Maria Costa do

    2004-01-01

    Full Text Available Utilizando-se biodigestores contínuos, abastecidos com dejetos de bovinos leiteiros e operados sob três tempos de retenção hidráulica, avaliou-se o efeito do processo de digestão anaeróbia sobre o número de microrganismos indicadores de poluição fecal, sobre a ocorrência de ovos e larvas de helmintos parasitas de ruminantes, analisando-se também os teores de sólidos totais e voláteis do afluente e dos efluentes, bem como a produção e a qualidade do biogás produzido. Verificou-se que vinte dias de retenção hidráulica foram suficientes para reduzir significativamente o número de microorganismos indicadores de poluição fecal e a quantidade de ovos de helmintos parasitas de ruminantes. Os resultados obtidos nas análises de sólidos totais e voláteis, bem como a produção de biogás (m³/dia, permitem concluir que o biodigestor modelo Chinês operado com 20 dias de tempo de retenção hidráulica, apresentou mais eficiência. Vale ressaltar que vinte dias de retenção foram insuficientes para impedir a sobrevivência de larvas de helmintos parasitas de ruminantes.

  12. E-Approval Plans in Research Libraries

    Science.gov (United States)

    Pickett, Carmelita; Tabacaru, Simona; Harrell, Jeanne

    2014-01-01

    Research libraries have long invested in approval plan services, which offer an economical way to acquire scholarly and scientific publications. Traditional approval plans have evolved and now enable libraries to expand their e-book offerings to better serve researchers. Publishers offer a myriad of e-book purchasing options. These range from…

  13. 48 CFR 2922.103-4 - Approvals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Approvals. 2922.103-4 Section 2922.103-4 Federal Acquisition Regulations System DEPARTMENT OF LABOR SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Basic Labor Policies 2922.103-4 Approvals. The “agency...

  14. 38 CFR 21.7220 - Course approval.

    Science.gov (United States)

    2010-07-01

    ...) VOCATIONAL REHABILITATION AND EDUCATION All Volunteer Force Educational Assistance Program (Montgomery GI...; Pub. L. 98-525) (b) Course approval criteria. In administering benefits payable under 38 U.S.C...) Section 21.4265—Practical training approved as institutional training or on-job training; (10) Section 21...

  15. Ordinal Position, Approval Motivation, and Interpersonal Attraction

    Science.gov (United States)

    Nowicki, Stephen, Jr.

    1971-01-01

    Results of the study suggest that birth-order effects might be included within the wider framework of approval-dependency theory. Females tend to account for a significant share of birth-order effects. More particularly, firstborn females accounted for much of the differences in expressed attraction as well as need for social approval. (Author)

  16. 30 CFR 14.10 - Post-approval product audit.

    Science.gov (United States)

    2010-07-01

    ..., AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.10 Post-approval product audit. (a) Approved conveyor belts will be subject to... based. MSHA will select an approved conveyor belt to be audited; the selected belt will be...

  17. Analysis of the Education Program Approval Process: A Program Evaluation.

    Science.gov (United States)

    Fountaine, Charles A.; And Others

    A study of the education program approval process involving the Veterans Administration (VA) and the State Approving Agencies (SAAs) had the following objectives: to describe the present education program approval process; to determine time and costs associated with the education program approval process; to describe the approval process at…

  18. 30 CFR 18.95 - Approval of machines constructed of components approved, accepted or certified under Bureau of...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approval of machines constructed of components... APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.95 Approval of machines constructed of components approved...

  19. 27 CFR 5.55 - Certificates of label approval.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Requirements for Approval of... certificates of label approval and certificates of exemption from label approval, as well as appeal procedures...

  20. FDA approves efavirenz. Food and Drug Administration.

    Science.gov (United States)

    Highleyman, L

    1998-10-01

    The Food and Drug Administration (FDA) approved DuPont Pharma's new non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz (Sustiva, DMP-266). Efavirenz has shown promise in trials with over 2000 participants for up to 24 weeks, and early data suggests it may be as effective as protease inhibitors when used in a combination regimen. It is the first anti-HIV drug approved for once-daily dosing. Efavirenz is well tolerated, and the main side effects reported are dizziness, insomnia, abnormal dreams, and skin rash. Efavirenz has been approved for adults and children, but should not be used by pregnant women. Contact information is provided.

  1. Perspectives used for gaining approval of budgets.

    Science.gov (United States)

    Franks-Joiner, G L

    1990-01-01

    Nurse executives think about problems using a certain perspective which may influence decisions on budgetary matters. The nurse executives' perspective used in decision-making may influence which budget proposals are developed and approved. A study was performed to determine the perspective used by nurse executives in decision-making on supplementary budget item proposals and whether perspective use influenced approval. Findings showed that use of the system view or dual-domain perspective in a proposal may enhance nurse executives' changes of gaining approval.

  2. Approving of personal dosimeter services

    International Nuclear Information System (INIS)

    Bergman, K.; Malmqvist, L.

    2001-09-01

    The Swedish regulation SSI FS 98:5 requires that radiological workers of category A use dosemeters from an approved personal dosimetry service. The regulation also includes certain specific dosimeter requirements, which are based on those presented in the Technical Recommendations by the European Commission (Report EUR 14852 EN, 1994). All services have been tested for their ability to determine Hp(10) and some of them to determine Hp(0.07) at one radiation quality. The test was performed in the interval 0.2 mSv to 100 mSv at three different dose equivalents unknown to the system owner. The 11 services operating in Sweden at the moment use 5 different types of dosimeters. The five unique systems have been tested regarding the angular and energy dependence of the response of the dosimeters. The dosimeters were irradiated to a personal dose equivalent of about 1 mSv at three photon energies and at four angles (0, 20, 40 and 60 deg. resp. ) both vertically and horizontally rotated. Only 2 of the services determine Hp(0.07) for beta and gamma radiation and were tested for this quantity. The test results for Hp(10) are all except two within the trumpet curve. For the unique systems it is shown that the uncertainty related to angular response at a specified energy is within the required ±40 % except for the lowest X-ray quality at 40 kV. The response is more dependent on photon energy than on the direction of the photon radiation and the choice of radiation quality for the calibration is of great importance for the system performance

  3. 75 FR 29803 - Agency Information Collection Activity Seeking OMB Approval

    Science.gov (United States)

    2010-05-27

    ... Turbine Engine Powered Airplanes. Type of Request: Extension without change of a currently approved....S. EPA pollution requirements in lieu of searching through extensive paper records. ADDRESSES...

  4. BMI or BIA: Is Body Mass Index or Body Fat Mass a Better Predictor of Cardiovascular Risk in Overweight or Obese Children and Adolescents? A German/Austrian/Swiss Multicenter APV Analysis of 3,327 Children and Adolescents.

    Science.gov (United States)

    Bohn, Barbara; Müller, Manfred James; Simic-Schleicher, Gunter; Kiess, Wieland; Siegfried, Wolfgang; Oelert, Monika; Tuschy, Sabine; Berghem, Stefan; Holl, Reinhard W

    2015-01-01

    Body fat (BF) percentiles for German children and adolescents have recently been published. This study aims to evaluate the association between bioelectrical impedance analysis (BIA)-derived BF and cardiovascular risk factors and to investigate whether BF is better suited than BMI in children and adolescents. Data of 3,327 children and adolescents (BMI > 90th percentile) were included. Spearman's correlation and receiver operating characteristics (ROCs) were applied determining the associations between BMI or BF and cardiovascular risk factors (hypertension, dyslipidemia, elevated liver enzymes, abnormal carbohydrate metabolism). Area under the curve (AUC) was calculated to predict cardiovascular risk factors. A significant association between both obesity indices and hypertension was present (all p risk factors. BF significantly predicted hypertension (AUC = 0.61), decreased HDL-cholesterol (AUC = 0.58), elevated LDL-cholesterol (AUC = 0.59), elevated liver enzymes (AUC = 0.61) (all p risk factors, no significant differences between BMI and BF were observed. BIA-derived BF was not superior to BMI to predict cardiovascular risk factors in overweight or obese children and adolescents.

  5. The tourism potential of the commune Janów Podlaski and its evaluation of tourism appeal as compared to the administrative district of Biała Podlaska (Lublin voivodeship)

    Science.gov (United States)

    Skrzypczak, Andrzej; Chmielewska, Anna Beata

    2009-01-01

    The purpose of this thesis has been to evaluate tourism appeal of the commune of Janów Podlaski, as compared to the other communes in the administrative district of Biała Podlaska, and to analyse the recreational potential of the natural environment within the commune and it's present day infrastructure for tourism industry. For evaluation of the tourism attractiveness of the commune, based on comparative analysis, the method of synthetic measures was applied. The commune of Janów Podlaski belongs to one of the most attractive areas for tourists in the administrative district of Biała Podlaska. The attractiveness of the commune is associated with the Bug river, which flows across high-value landscapes and possess many ecological assets. Development of water tourism, however, is hindered by the fact that the Bug forms part of Poland's state border and it's water is rather polluted. Walking tourism in the commune of Janów Podlaski is encouraged owing to a well-developed and properly sing-posted networks of trails. The accommodation facilities are not evenly distributed as most of the rooms for tourists can be found in Janów Podlaski.

  6. Avaliação da qualidade de vida em pacientes com fratura da tíbia Assessment of quality of life in patients with tibia fractures

    Directory of Open Access Journals (Sweden)

    Oswaldo Roberto Nascimento

    2009-01-01

    Full Text Available OBJETIVO: Avaliar o impacto da fratura na qualidade de vida dos pacientes. MÉTODO: Os pacientes foram submetidos a um protocolo de dados clínicos e epidemiológicos, a uma avaliação específica para fraturas da tíbia, o método de Johner e Wruhs, cujo dados foram analisados por um questionário genérico para avaliação da qualidade de vida, o SF-36, o qual foi aplicado pelos autores, com um mínimo de seis meses de pós-operatório. Estes instrumentos foram também estratificados com relação ao retorno ou não dos pacientes a todas as atividades que realizavam antes do acidente. RESULTADOS: Observou-se uma diminuição dos valores de avaliação do questionário SF-36 demonstrada estatisticamente (pOBJECTIVE: To evaluate the impact of tibial fractures on patient's quality of life. METHOD: All patients were evaluated by means of a protocol of clinical and epidemiological data. The Johner and Wruhs method was employed to evaluate tibial fractures and the results were compared to those of the SF-36 Health Survey, which was applied by the authors from the sixth month postoperatively. Those methods were applied considering the return of the patients or not to all the activities they used to perform before the accident. RESULTS: We found a statistical significance (p<0.05 showed by Mann- Whitney's U-test between the component of SF-36, and return or not to previous activities. Regarding the results of SF36 and clinical evaluation (Johner and Wruhs, on the Kruskal-Wallis' test, we also found significant correlation. CONCLUSION: According to the established criteria and based on the results, tibial fractures, even with favorable clinical outcomes, result in a diminished quality of life.

  7. Percent body fat and BMI in indigenous and mestizo children from South, Centre and North Mexico derived from bioimpedance analysis (BIA) and deuterium oxide dilution

    International Nuclear Information System (INIS)

    Valencia, Mauro E; Ramirez-Lopez, Erik; Ramos-Salas, Je; Bourges, Hector; Espinoza, Teresa

    2014-01-01

    Full text: Background. Body mass index (BMI) is an international standard to evaluate nutritional status but has the inability to distinguish fat mass from fat free mass, especially with regards to ethnicity. Mexico is the eight country in ethnic diversity in the world. The changes in fat mass and fat free mass offers the possibility to evaluate the effects of intervention programs in shorter periods. Objective. The purpose of the present study was to investigate the relationship between body composition and anthropometric characteristics of indigenous and mestizo Mexican children. Subject and Methods. A total of 1618 male and female indigenous (n = 498) and mestizo (n = 1120) children 7-9 years, were selected by stratified multiple stage cluster sampling. Indigenous groups and States were: Tarahumaras (Chihuahua), Mayos (Sonora), Nahuas (Puebla), Otomíes (Hidalgo), Tzotziles (Chiapas) and Mayas (Yucatan Peninsula). Mestizos form the same regions were included. Fat free mass and fat mass were obtained from a previously reported BIA cross validated equation using deuterium oxide dilution from 339 children from the same population, groups and regions. Results. The indigenous groups had 18.5 + 5.9 % fat compared to 23.5 + 8.4 in the mestizos (p<0.0001). Nahuas had the lowest % fat (p<0.0001) with 16.5 + 5.7, compared to Mayos, Tarahumaras and Mayas that had 18.6 + 6.2, 19.0 + 6.3 and 18.0 + 6.5 respectively. Mestizos form the Centre, North, and South had the highest levels of % body fat (p<0.001) with 25.4 + 7.7, 21.9 + 8.2, and 20.5 + 7.8, respectively. In indigenous children (n = 498) the 5th percentile (95% CI) corresponded to 9 (8,10) % body fat, while for Mestizos (n = 1120), the 5th percentile was 10 (9,11). Using this percentile, only one third of the children approximately of both groups would be classified as thin by WHO and IOTF classifications. Conclusion. Indigenous children had lower body fat than mestizos, however, the relationship of BMI to % body fat

  8. Caracterização e biodigestão anaeróbia dos dejetos de caprinos Characterization and anaerobic digestion of goat manure

    Directory of Open Access Journals (Sweden)

    Ana C. A. Orrico

    2007-12-01

    Full Text Available Quantificar e caracterizar os dejetos gerados por cabras Saanen em quatro categorias de idade e alimentadas com três dietas e na seqüência, e promover a biodigestão anaeróbia dos dejetos constituíram os objetivos deste trabalho. Para a produção de dejetos, foram utilizadas 36 cabras Saanen, com idades entre 2 e 4 (C1, 4 e 8 (C2, 8 e 12 (C3 e acima de 12 meses (C4, alimentadas com as dietas 1 (D1: 80% volumoso (Vol e 20% concentrado (Con; 2 (D2: 60% Vol e 40% Con e 3 (D3: 40% Vol e 20% Con. Foram quantificadas as produções diárias de fezes e urina e seus teores em N, P, K, Ca, Mg, Na, Fe, Cu, Zn e Mn. Com a mistura das fezes e urina de todas as categorias, separadas segundo as dietas, foram abastecidos biodigestores batelada, com capacidade para 4 L de substrato em fermentação. A C1 apresentou menor (PThis study aimed quantify and characterize the manure generated by Saanen goats in four categories of age, fed with three diets and then promote the anaerobic digestion of the manures. Thirty six goats were used with ages between 2 and 4 (C1, 4 and 8 (C2, 8 and 12 (C3 and above 12 months (C4, fed with the diets 1 (D1: 80% forage (Fo and 20% concentrated (Co, 2 (D2: 60% Fo and 40% Co and 3 (D3: 40% Fo and 20% Co. The daily productions of feces and urine and its contents of N, P, K, Ca, Mg, Na, Fe, Cu, Zn and Mn were quantified. A mixture of feces and urine of all the categories of age was used; separated according to the diets, for the supply of batch digesters, with capacity of 4.0 liters of substrate in fermentation. The C1 presented smaller excretion (P<0.05 of feces (164.1 g of MS/animal per day and the smallest food consumption (362.16 g MS/animal per day. The largest concentrations of N, P, K, Ca, Mg and K occurred in the feces and urine generated by goats of C4 and fed by D3. The prepared substrate with manures originating from of D3 presented 45% of reduction in the contents of volatile solids (VS. The prepared substrate with

  9. Drugs Approved for Stomach (Gastric) Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for stomach (gastric) cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  10. Drugs Approved for Gastrointestinal Stromal Tumors

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gastrointestinal stromal tumors (GIST). The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  11. Drugs Approved for Colon and Rectal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for use in colon cancer and rectal cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  12. Drugs Approved for Soft Tissue Sarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for soft tissue sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  13. Drugs Approved for Head and Neck Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for head and neck cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  14. Drugs Approved for Gestational Trophoblastic Disease

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gestational trophoblastic disease. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  15. FDA Approves First Therapeutic Cancer Vaccine

    Science.gov (United States)

    Sipuleucel-T (Provenge) is a relatively nontoxic treatment option for men with hormone-resistant or castration-resistant prostate cancer. The FDA's approval of the vaccine represented the first proof of principle that immunotherapy can work in cancer.

  16. 19 CFR 115.42 - Approval plates.

    Science.gov (United States)

    2010-04-01

    ... possible methods of accomplishing this are: (1) Placing an “X” in front of the numeric portion of the... element of such number. The specific method of altering the approval number may be established by each...

  17. Page | 133 LEGISLATIVE APPROVAL OF EXECUTIVE ...

    African Journals Online (AJOL)

    Fr. Ikenga

    NAUJILJ 9 (2) 2018. Page | 133 ... Keywords: Executive appointments, Legislative approval, National Assembly, Constitutional duty. 1. ... Representatives is led by a Speaker.6 The election of the leadership of the senate is entirely the affair of.

  18. 7 CFR 3565.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... exist among the borrower, contractor, lender, syndicator, management agent, suppliers of materials or... Agency to guarantee a loan subject to the stated terms and conditions. Correspondent relationship. A contractual relationship between an approved lender and a non-approved lender or mortgage broker in which the...

  19. 40 CFR 52.2352 - Change to approved plan.

    Science.gov (United States)

    2010-07-01

    ... Utah's approved State Implementation Plan (SIP). This rule language pertains to State Sales Tax... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Change to approved plan. 52.2352... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Utah § 52.2352 Change to approved...

  20. 78 FR 2315 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-01-10

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  1. 78 FR 15402 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-03-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  2. 78 FR 11947 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-02-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  3. 78 FR 17281 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-03-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  4. 77 FR 16317 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-03-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  5. 77 FR 66909 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-11-07

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... below, receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  6. 77 FR 21143 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-04-09

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  7. 77 FR 25010 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-04-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... below, receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  8. 77 FR 34455 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-06-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  9. 77 FR 55891 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  10. 77 FR 55892 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  11. 77 FR 59239 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  12. 76 FR 53362 - Approval of Farm Credit System Lending Institutions in FHA Mortgage Insurance Programs

    Science.gov (United States)

    2011-08-26

    ... marketing activities, and to farm-related businesses. The Farm Credit banks collectively issue debt... institutions. The four farm credit banks, one agricultural credit bank (hereinafter collectively referred to as the Farm Credit banks), and their direct lender associations (the Agricultural Credit Associations...

  13. 76 FR 24507 - HUD Multifamily Rental Project Closing Documents: Notice Announcing Final Approved Documents and...

    Science.gov (United States)

    2011-05-02

    ... transactions, although these are familiar roles in commercial lending transactions. Accordingly, HUD has... advantage of this language is that it identifies the specific, longstanding, and familiar types of... the documents, HUD is limiting its role and giving lenders more ability to address any problems that...

  14. 78 FR 72951 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2013-12-04

    ... regarding the risks and financial impact associated with the customer's loan of securities, and requires... the introducing member that has a customer relationship with the lender in making the determination... securities, and the risks and financial impact associated with the customer's loan of securities. Proposed...

  15. Radiological Medical Device Innovation: Approvals via the Premarket Approval Pathway From 2000 to 2015.

    Science.gov (United States)

    Ghobadi, Comeron W; Hayman, Emily L; Finkle, Joshua H; Walter, Jessica R; Xu, Shuai

    2017-01-01

    The aim of this study was to critically assess the clinical evidence leading to radiologic medical device approvals via the premarket approval pathway from 2000 to 2015. This study used the publically available FDA premarket database for radiologic device approvals over the past 15 years (September 1, 2000, to August 31, 2015). Approval characteristics were collected for each device, and statistical analysis was performed on the data for each pivotal trial. Additionally, methodological quality of the pivotal trial was determined using the Quality Assessment of Diagnostic Accuracy Studies tool. Twenty-three class III radiologic device approvals were identified, with breast imaging accounting for 16 (70%) and computer-aided detection software accounting for 9 (39%) approvals. The median premarket approval time was 475 days (range, 180-1,116). Twenty-one devices were approved on the basis of multireader, multicenter studies, one on the basis of a randomized controlled trial, and one on the basis of a preclinical technical equivalence trial. The median number of patients per pivotal trial was 201 (range, 25-3,946). Twenty-six of the 34 pivotal trials (76%) had at least one methodologic bias. Breast imaging devices had a greater number of patients per pivotal trial (P = .009) and more prospective studies. With regard to all modalities, increased time to device approval correlated with weaker trial quality (r = 0.600, P assessing diagnostic technologies. Given that radiologic devices play a key role in modern medicine, further efforts should be made to increase transparency of clinical data leading to approval. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  16. Anaerobic co-digestion of crude glycerin and starch industry effluent Codigestão anaeróbia de glicerina bruta e efluente de fecularia

    Directory of Open Access Journals (Sweden)

    Andrea C. Larsen

    2013-04-01

    Full Text Available The Brazil's Biodiesel Production and Use Program introduces biodiesel in the Brazilian energy matrix, bringing along the perspective of a growth of the glycerin offer, co-product generated in the proportion of 10 kg for each 100 L of biodiesel. The aim of this study was to evaluate the addition of crude glycerin in the anaerobic digestion of cassava starch industry effluent (cassava wastewater, in a horizontal semi-continuous flow reactor of one phase in laboratory scale. It was used a reactor with a 8.77 L of useful volume, a medium support for corrugated conduit of polyvinyl chloride (PVC, temperature of 261 ºC, fed with cassava wastewater and glycerin, with hydraulic detention times of 4 and 5 days and increasing volumetric organic load of 3.05; 9.32; 14.83 and 13.59 g COD L-1 d-1, obtained with the addition of glycerin at 0; 2; 3 and 2% (v/v, respectively. The average removal efficiencies of TS and TVS were decreasing from the addition of glycerin to the cassava wastewater, averaging 81.19 to 55.58% for TS and 90.21 to 61.45% for TVS. The addition of glycerin at 2% increased the biogas production compared to the control treatment, reaching 1.979 L L-1 d-1. The biogas production as a function of the consumed COD was higher for the control treatment than for the treatments with addition of glycerin, which indicates lower conversion of organic matter into biogas.O Programa Nacional de Produção e Uso do Biodiesel introduziu o biodiesel na matriz energética brasileira, trazendo a perspectiva de aumento da oferta de glicerina, coproduto gerado na proporção de 10 kg para cada 100 L de biodiesel. O objetivo principal deste trabalho foi avaliar a adição de glicerina bruta na digestão anaeróbia de efluente de indústria de fécula de mandioca (manipueira, em reator de fluxo semicontínuo horizontal de uma fase, em escala de laboratório. Foi utilizado um reator com volume útil de 8,77 L, meio suporte em eletroduto corrugado de policloreto

  17. Ekspresja kinazy Jak3 i aktywacja białka Stat3 u chorych na reumatoidalne zapalenie stawów i spondyloartropatie zapalne

    Directory of Open Access Journals (Sweden)

    Andrzej Steciwko

    2010-08-01

    Full Text Available Wstęp: Układ przekaźnikowy Jak/Stat (kinaza tyrozynowaJanus/sygnał transdukcji i aktywacji transkrypcji jest wykorzystywanyprzez wiele cytokin, czynników wzrostu i hormonów regulującychmechanizmy transkrypcji genów oraz aktywacji, proliferacji,różnicowania i apoptozy komórek. Wyniki dotychczasowych badańwskazują, że kinaza Jak3 odgrywa istotną rolę w patogeneziereumatoidalnego zapalenia stawów (RZS. Cel pracy: Ocena ekspresji Jak3 oraz aktywacji Stat3 w leukocytachkrwi obwodowej (LKO i komórkach płynu stawowego (KPSu chorych na RZS i spondyloartropatie zapalne (SpaZ oraz analizazwiązku badanych parametrów ze wskaźnikami aktywności chorobyużywanymi w praktyce klinicznej. Ponadto analizie poddanozależności między ekspresją Jak3 a aktywacją Stat3. Materiał i metody: Do badania zakwalifikowano 19 chorych na RZSoraz 22 chorych na SpaZ (zesztywniające zapalenie stawów, łuszczycowezapalenie stawów, spondyloartropatia niezróżnico wana.Grupę kontrolną stanowiły 23 zdrowe osoby. W badanych grupachw LKO metodą immunocytochemiczną oznaczono ekspresję kinazyJak3 i aktywację białka Stat3. Tą samą metodą oznaczono ekspresjęJak3 i aktywację Stat3 u 11 chorych na RZS i u 12 chorych na SpaZw KPS. U chorych zostały oznaczone warto ści parametrów stanuzapalnego oraz wskaźników aktywności choroby DAS28 i BASDAI.Wykonano rentgenogramy stawów zajętych procesem chorobowym. Wyniki: Ekspresja Jak3 oraz aktywacja Stat3 były znacząco wyższeu chorych na RZS i SpaZ w porównaniu z grupą kontrolną. War to -ści te były wyższe w KPS niż w LKO. U chorych na RZS zaobserwowanododatnią korelację między aktywnością Stat3 w KPSa wartością CRP. Nie wykazano korelacji między ekspresją Jak3a aktywacją Stat3. Wnioski: Funkcja Jak3 i Stat3 jest związana z procesem immunolo -gicznym w przebiegu RZS i SpaZ. Wydaje się, że zablokowanie ichfunkcji może stanowić cel terapeutyczny w obydwu grupach chorych.

  18. O aterro da caturrita em Santa Maria – RS: uma atualização quanto aos potenciais da digestão anaeróbia

    Directory of Open Access Journals (Sweden)

    Tiago Luis Gomes

    2009-01-01

    Full Text Available As oportunidades do processo de digestão anaeróbia, em aterros sanitários e controlados, são ligadas à formação de biogásatravés da biodegradação da matéria orgânica em ambiente predominantemente anaeróbio. Com isso, através de um ajuste decapacidade do aterro da Caturrita em Santa Maria-RS, que consiste no produto entre a massa de resíduos (467.929 toneladas quecomporta a célula e o fator de recuperação do gás metano (RF=0,7, sendo o mesmo relacionado, principalmente ao percentual deresíduos domésticos que chegam ao aterro (alto teor de matéria orgânica de fácil degradação, obteve-se um aproveitamento potencialde 327.550 toneladas de resíduos depositados, resultando num aterro com baixa capacidade de produção de biogás. A recuperaçãototal do metano entre 2013 e 2033, considerando um rendimento na captação de gases de 70%, resultou 17.529.657m3, através dautilização do método Scholl Canyon. O total da receita estimada para o mesmo período, admitindo uma comercialização conservadora(aterro Bandeirantes em São Paulo que é de € 19,20 de créditos de carbono em € 10,00 por tonelada equivalente de CO2 (eCO2, eenergia elétrica em um valor de € 0,0326/kWh que é referência para o projeto NovaGerar no Rio de Janeiro, seria de € 3.604.650, ouem torno de R$ 11.030.229, isto é, um faturamento mensal de R$ 45.960,00.Abstract The anaerobic digestion process opportunities,about sanitary and controlled landfills, are related to a biogasformation process through the biodegradation of organicsubstances in a predominantly anaerobic environment. Thus,through capacity adjustment of the Caturrita’s landfill in SantaMaria-RS reached an exploitation potential of 327,550 tons ofdeposited residues, resulting in a landfill, which has a lowbiogas production capacity. The methane recovered between2013 and 2033, considering an availability of 70%, came to be17,529,657m3. Admitting the carbon credits and electricenergy

  19. Desempenho da potência anaeróbia em atletas de elite do mountain bike submetidos à suplementação aguda com creatina Anaerobic power output of elite off-road cyclists with acute oral creatine supplementation

    Directory of Open Access Journals (Sweden)

    Guilherme Eckhardt Molina

    2009-10-01

    Full Text Available Com o objetivo de investigar os efeitos da suplementação aguda com creatina no desempenho da potência anaeróbia de atletas de elite do mountain bike, 20 atletas em período básico do macrociclo de treinamento foram distribuídos aleatoriamente (duplo-cego em dois grupos: placebo (PLA, n = 10 e creatina (CRE, n = 10. Foram avaliados quanto à composição corporal (pesagem hidrostática e potência anaeróbia (teste de Wingate - TW antes (PRÉ e depois (PÓS de sete dias de suplementação. A creatina ou maltodextrina foi usada em três doses diárias de 0,3g/kg de massa corporal diluídos em meio líquido adoçado. Não foram observadas diferenças significativas nas variáveis morfológicas após sete dias de suplementação (PRÉ x PÓS, e os grupos não diferiram apesar da variação percentual (Δ% contrária (positiva para o grupo CRE e negativa para o PLA. A potência anaeróbia pico (PP e o instante da potência pico (IPP aumentaram e o índice de fadiga diminuiu do PRÉ para o PÓS-testes no grupo CRE, enquanto que o grupo PLA não apresentou diferenças significantes. A PP apresentou forte tendência em ser maior e o IPP foi maior no grupo CRE comparado com o PLA. Conclui-se que existem evidências de que a suplementação com creatina (0,3g/kg em curto prazo (sete dias pode retardar o IPP (CRE 3,0 ± 0,5/3,6 ± 0,8 Δ%= 20% no teste de Wingate em atletas de elite do mountain bike, sugerindo que a suplementação com creatina pode melhorar o desempenho físico quanto à potência anaeróbia durante o trabalho de alta intensidade e curta duração.In order to investigate the effect of a high dose, acute oral creatine supplementation on anaerobic power of male off-road cyclists, twenty elite athletes training at the basic period were randomly (double-blind assigned into 2 groups: placebo (PLA n=10 and creatine (CRE n=10. They were submitted to a body composition evaluation (underwater weighting and Wingate Anaerobic Test (TW before

  20. USO DE REMEDIADORES BIOLÓGICOS NA BIODIGESTÃO ANAERÓBIA DA CAMA DE FRANGO DE CORTE / USE OF BIOLOGICAL REMEDIATION IN ANAEROBIC BIO-DIGESTION OF THE POULTRY LITTER

    Directory of Open Access Journals (Sweden)

    L. V. C. DA COSTA

    2012-11-01

    Full Text Available A cama de frango subproduto gerado na produção de aves de corte, vem sendo cada vez mais reutilizada pelos produtores, sendo essa cama muitas vezes composta por produtos disponível em determinada região, como o bagaço de cana,casca de amendoim, casca de arroz, etc, produtos esses classificados como altamente lignificados e de difícil degradação,principalmente quando se trabalha com tratamento em biodigestão anaeróbia, dificultando a atuação de bactérias metanogênicas.Baseado nesse exposto, o objetivo desse  trabalho foi avaliar a inclusão de remediadores biológicos na biodigestão anaeróbia da cama de frango que tiveram ou não a separação da fase sólida e líquida  e seu efeito na produção e qualidade de biogás. Foram utilizados 12 biodigestores modelo batelada de bancada abastecidos com cama de frango de 3º lote de reutilização e remediadores biológicos comercial. O tempo de retenção hidráulica foi de 120 dias. Observou-se que os tratamentos que não tiveram a separação de sólidos adicionados de remediadores biológicos foram os que mais produziram biogás, e a porcentagem de metano pelas médias não apresentou diferença entre os tratamentos. 

  1. Montana Advanced Biofuels Great Falls Approval

    Science.gov (United States)

    This November 20, 2015 letter from EPA approves the petition from Montana Advanced Biofuels, LLC, Great Falls facility, regarding ethanol produced through a dry mill process, qualifying under the Clean Air Act for advanced biofuel (D-code 5) and renewable

  2. Reflections on the Ethics-Approval Process

    Science.gov (United States)

    Murray, Lee; Pushor, Debbie; Renihan, Pat

    2012-01-01

    It is sometimes a difficult journey receiving ethics approval for research involving vulnerable populations, research involving our own children, or innovative research methodologies such as autoethnography. This autoethnographical account is a story about one student who wanted to write a PhD dissertation in a very different way and also the…

  3. Drugs@FDA: FDA Approved Drug Products

    Science.gov (United States)

    ... Cosmetics Tobacco Products Home Drug Databases Drugs@FDA Drugs@FDA: FDA Approved Drug Products Share Tweet Linkedin Pin it More sharing ... Download Drugs@FDA Express for free Search by Drug Name, Active Ingredient, or Application Number Enter at ...

  4. 15 CFR 1150.3 - Approved markings.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Approved markings. 1150.3 Section 1150.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... permanently affixed to the exterior surface of the barrel, covering the circumference of the barrel from the...

  5. The Ethics and Politics of Ethics Approval

    Science.gov (United States)

    Battin, Tim; Riley, Dan; Avery, Alan

    2014-01-01

    The regulatory scope of Human Research Ethics Committees can be problematic for a variety of reasons. Some scholars have argued the ethics approval process, for example, is antithetical to certain disciplines in the humanities and social sciences, while others are willing to give it qualified support. This article uses a case study to cast the…

  6. 7 CFR 1425.4 - Approval.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.4 Approval. (a) For a cooperative to gain CMA status to participate in a marketing assistance loan or Loan deficiency... prepared in accordance with generally accepted accounting principles; (3) A copy of the articles of...

  7. 7 CFR 966.124 - Approved receiver.

    Science.gov (United States)

    2010-01-01

    ... limited to, the following information: (1) Name, address, contact person, telephone number, and e-mail... 7 Agriculture 8 2010-01-01 2010-01-01 false Approved receiver. 966.124 Section 966.124 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements...

  8. Approval Plans in ARL Libraries. Kit 83.

    Science.gov (United States)

    Leonhardt, Thomas W.

    Materials in this collection were submitted by respondents to a survey which sought specific data on the numbers and types of approval plans in Association of Research Libraries (ARL) libraries, whether such plans are meeting expectations, their relative importance in the library, who makes the key decisions, and the kind of thought and study that…

  9. Neratinib Approved for HER2+ Breast Cancer.

    Science.gov (United States)

    2017-09-01

    The FDA approved the tyrosine kinase inhibitor neratinib for extended adjuvant treatment of early-stage HER2-positive breast cancer. The decision adds another treatment option to help prevent recurrence, but its relatively small potential benefit must be weighed against the risk of serious side effects. ©2017 American Association for Cancer Research.

  10. 50 CFR 223.207 - Approved TEDs.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Approved TEDs. 223.207 Section 223.207 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Restrictions Applicable to Threatened Marine and Anadromous Specie...

  11. 7 CFR 1427.10 - Approved storage.

    Science.gov (United States)

    2010-01-01

    ... § 1427.10 Approved storage. (a) Eligible cotton may be pledged as collateral for loans only if stored at... receipt for any bale or bales of cotton pledged as collateral for a CCC loan must include the dates that... cotton pledged as collateral for a CCC loan that are stored outside, and (ii) Through their electronic...

  12. 40 CFR 52.2522 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... plant, Monongahela Power Co. (b) The Administrator hereby extends the interim limitation of 5.12 lbs. SO2 per million BTU for the Harrison power plant until a permanent emission limitation is approved. (c...-10 NAAQS. (h) EPA disapproves the portion of 45 CSR 13 subsection 1 referencing major stationary...

  13. 9 CFR 317.4 - Labeling approval.

    Science.gov (United States)

    2010-01-01

    ... undue economic hardship; and (iv) An unfair competitive advantage would not result from the granting of... Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... approval to the Food Labeling Division, Regulatory Programs, Food Safety and Inspection Service, and...

  14. Drug lag for cardiovascular drug approvals in India compared with the US and EU approvals

    Directory of Open Access Journals (Sweden)

    Bhaven C. Kataria

    2013-01-01

    Conclusion: This study confirms that there is a substantial drug lag in approval of new cardiovascular drugs in India compared with the United States and European Union. The impact of drug lag on health outcomes remains to be established.

  15. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

    Science.gov (United States)

    2010-07-01

    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... having jurisdiction at the mine where such equipment is to be operated stating the modifications which...

  16. Trends in global approvals of biotech crops (1992–2014)

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    ABSTRACT With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992–2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits. PMID:26039675

  17. Trends in global approvals of biotech crops (1992-2014).

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

  18. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  19. 7 CFR 1710.105 - State regulatory approvals.

    Science.gov (United States)

    2010-01-01

    ... and Basic Policies § 1710.105 State regulatory approvals. (a) In States where a borrower is required... loans are approved by RUS: (1) Loans requiring an Environmental Impact Statement; (2) Loans to finance...

  20. 27 CFR 4.50 - Certificates of label approval.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements for Approval of Labels of... of exemption from label approval, as well as appeal procedures, see part 13 of this chapter. [T.D...

  1. 22 CFR 96.63 - Renewal of accreditation or approval.

    Science.gov (United States)

    2010-04-01

    ... for renewal in a timely fashion. Before deciding whether to renew the accreditation or approval of an... accrediting entity or the Secretary during its most current accreditation or approval cycle, the accrediting...

  2. Clone of EPA Approved Regulations in the Texas SIP

    Science.gov (United States)

    changed name to EPA Approved Regulations in the Texas SIP, Add links to:Texas Read Me; Texas SIP History;Current/Previous SIP-Approved Regulations; Delete regulations--now in /node/191099, removed tables

  3. 75 FR 56663 - Agency Information Collection (Quarterly Report of State Approving Agency Activities); Activity...

    Science.gov (United States)

    2010-09-16

    ... a currently approved collection. Abstract: VA reimburses State Approving Agencies (SAAs) for expenses incurred in the approval and supervision of education and training programs. SAAs are required to...

  4. The approval mechanism solves the prisoner's dilemma theoretically and experimentally

    OpenAIRE

    Tatsuyoshi Saijo; Yoshitaka Okano; Takafumi Yamakawa

    2015-01-01

    Consider a situation where players in a prisoner's dilemma game can approve or reject the other's choice such as cooperation or defection. If both players approve the other's choice, the outcome is the one they chose, whereas if either one rejects the other's choice, the outcome is the one when both defect, which we name the approval mechanism herein (this is inspired by the Cold War doctrine of mutually assured destruction). Experimentally, we find that the cooperation rate with the approval...

  5. 19 CFR 115.55 - Termination of approval.

    Science.gov (United States)

    2010-04-01

    ... vehicle by a major repair or alteration of any of the essential features required in § 115.51. Repairs by... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Individual Road Vehicles § 115.55 Termination of approval. Approval of a road...

  6. 30 CFR 75.1108 - Approved conveyor belts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approved conveyor belts. 75.1108 Section 75... Fire-Resistant Hydraulic Fluids on Underground Equipment § 75.1108 Approved conveyor belts. (a) Until December 31, 2009 conveyor belts placed in service in underground coal mines shall be: (1) Approved under...

  7. 48 CFR 52.222-16 - Approval of Wage Rates.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Approval of Wage Rates. 52....222-16 Approval of Wage Rates. As prescribed in 22.407(b), insert the following clause: Approval of Wage Rates (FEB 1988) All straight time wage rates, and overtime rates based thereon, for laborers and...

  8. 33 CFR 115.70 - Advance approval of bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges prior...

  9. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status is...

  10. 12 CFR 614.4470 - Loans subject to bank approval.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Loans subject to bank approval. 614.4470 Section 614.4470 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Loan Approval Requirements § 614.4470 Loans subject to bank approval. (a) The following loans...

  11. 49 CFR 1522.109 - TSA review and approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false TSA review and approval. 1522.109 Section 1522.109..., DEPARTMENT OF HOMELAND SECURITY SECURITY RULES FOR ALL MODES OF TRANSPORTATION TSA-APPROVED VALIDATION FIRMS AND VALIDATORS TSA-Approved Validation Firms and Validators for the Certified Cargo Screening Program...

  12. 49 CFR 1522.115 - Renewal of TSA approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Renewal of TSA approval. 1522.115 Section 1522.115..., DEPARTMENT OF HOMELAND SECURITY SECURITY RULES FOR ALL MODES OF TRANSPORTATION TSA-APPROVED VALIDATION FIRMS AND VALIDATORS TSA-Approved Validation Firms and Validators for the Certified Cargo Screening Program...

  13. 45 CFR 1340.13 - Approval of applications.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Approval of applications. 1340.13 Section 1340.13... NEGLECT PREVENTION AND TREATMENT PROGRAM CHILD ABUSE AND NEGLECT PREVENTION AND TREATMENT Grants to States § 1340.13 Approval of applications. (a) The Commissioner shall approve an application for an award for...

  14. 29 CFR 1952.157 - Changes to approved plan.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS North Carolina § 1952.157 Changes to approved plan. (a) Legislation. (1) On March 29, 1994, the Assistant Secretary approved North Carolina's... section 17 of the Act as amended on November 5, 1990. (2) [Reserved] (b) The Voluntary Protection Program...

  15. 46 CFR 188.10-3 - Approved container.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Approved container. 188.10-3 Section 188.10-3 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-3 Approved container. This term means a container which is properly labeled, marked and approved by DOT for the commodity which it contains. [CGFR...

  16. 76 FR 66117 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-10-25

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... notice lists the projects, described below, receiving approval for the consumptive use of water pursuant...

  17. 76 FR 53526 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-08-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... lists the projects, described below, receiving approval for the consumptive use of water pursuant to the...

  18. 76 FR 42159 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-07-18

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... lists the projects, described below, receiving approval for the consumptive use of water pursuant to the...

  19. 77 FR 4859 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-01-31

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... notice lists the projects, described below, receiving approval for the consumptive use of water pursuant...

  20. 20 CFR 617.22 - Approval of training.

    Science.gov (United States)

    2010-04-01

    .... Perkins Vocational and Applied Technology Education Act, and employers). (i) This means that training is...) Conditions for approval. Training shall be approved for an adversely affected worker if the State agency...) available for an adversely affected worker. (i) This means that for the worker for whom approval of training...

  1. 28 CFR 551.11 - Authority to approve a marriage.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Authority to approve a marriage. 551.11... MISCELLANEOUS Marriages of Inmates § 551.11 Authority to approve a marriage. (a) The Warden may approve the marriage of a federal inmate confined in a federal institution. This authority may not be delegated below...

  2. 7 CFR 1717.609 - RUS approval of general manager.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS approval of general manager. 1717.609 Section... Operational Controls § 1717.609 RUS approval of general manager. (a) If a borrower's mortgage or loan contract... general manager of the borrower's system, such approval is hereby granted provided that the borrower is in...

  3. Credit Risk Management - Loan Approval Process

    Directory of Open Access Journals (Sweden)

    Lulzim Rashiti

    2016-03-01

    Full Text Available The aim of this study is on understanding the international regulations issued by Basel I, Basel II and Basel III to best supervise and manage credit risk management policies. Part of paper will focus on the description and impacts of the regulations and the pivotal importance they play in providing a sound banking system. Credit risk represents another important element that will be analysed considering that it lays the foundation during the loan consideration and approval process. The paper will also explain in detail procedures and responsibilities shared along the process of loan acceptance by a banker. To sum up, the overall process from application to loan approval or denial will be explained pointing out the implications that are faced along the way

  4. Nuclear safety review requirements for launch approval

    International Nuclear Information System (INIS)

    Sholtis, J.A. Jr.; Winchester, R.O.

    1992-01-01

    Use of nuclear power systems in space requires approval which is preceded by extensive safety analysis and review. This careful study allows an informed risk-benefit decision at the highest level of our government. This paper describes the process as it has historically been applied to U.S. isotopic power systems. The Ulysses mission, launched in October 1990, is used to illustrate the process. Expected variations to deal with reactor-power systems are explained

  5. Academic Program Approval and Review Practices

    Directory of Open Access Journals (Sweden)

    Don G. Creamer

    1999-08-01

    Full Text Available This report outlines general and specific processes for both program approval and program review practices found in 50 states and eight foreign countries and regions.  Models that depict these procedures are defined and the strengths and weakness of each are discussed.  Alternatives to current practice by state agencies in the U.S. are described that might provide for greater decentralization of these practices while maintaining institutional accountability.

  6. Radiation requirements for uranium project approvals

    International Nuclear Information System (INIS)

    Hondros, J.

    2014-01-01

    Uranium mining projects in Australia must receive approval under both state and national laws based on a wide ranging impact assessment of the project. The process may take a number of years and involves multiple levels and parts of government and public consultation and scrutiny. The impact assessment is broad and usually covers; environmental, social, health, public safety and economic aspects. Information provided in the approvals documentation needs to be presented in a credible and understandable manner for all audiences. This means making complex information simpler, while making sure that it maintains its technical integrity. Poorly communicated information, which is overly complex, overly simplified or incomplete, can result in significant delays to the project approval which can potentially impact on project timelines. For uranium projects, along with other projects involving radioactive materials, such as minerals sands and rare earths, radiation and its impacts usually draw a disproportionate amount of both government and public scrutiny compared to other potential impacts and risks. It is therefore of key importance that radiation assessments are properly performed and results clearly presented and communicated with sufficient detail for stakeholders to make informed decisions. It is also important to ensure that the radiation risk is presented in perspective with other risks of the project. This presentation outlines a structure for a radiation impact assessment based on experience from a number of projects in Australia. The structure aims to be clear and simple and ensure the right balance between scientific fact, digestible information and demonstrable competence. (author)

  7. 75 FR 48302 - Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval...

    Science.gov (United States)

    2010-08-10

    ....gov ). FOR FURTHER INFORMATION CONTACT: For information on credit account approval for reimbursable..., at (301) 851-2908. SUPPLEMENTARY INFORMATION: Title: Credit Account Approval for Reimbursable... Inspection Service [Docket No. APHIS-2010-0071] Notice of Request for Extension of Approval of an Information...

  8. 78 FR 54617 - Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval...

    Science.gov (United States)

    2013-09-05

    ...] Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval for... (202) 799-7039 before coming. FOR FURTHER INFORMATION CONTACT: For information on credit account... Coordinator, at (301) 851-2908. SUPPLEMENTARY INFORMATION: Title: Credit Account Approval for Reimbursable...

  9. Efeitos de 24 semanas de treinamento resistido sobre índices da aptidão aeróbia de mulheres idosas Effects of 24 weeks of resistance training on aerobic fitness indexes of older women

    Directory of Open Access Journals (Sweden)

    Marcelo Guido

    2010-08-01

    Full Text Available INTRODUÇÃO E OBJETIVO: O consumo de oxigênio pico (VO2pico e o limiar anaeróbio (LA são amplamente aceitos como importantes medidas da aptidão aeróbia. Tradicionalmente, o treinamento aeróbio é visto como o principal meio de se aumentar esses índices. Em contrapartida, o treinamento resistido (TR não é tipicamente prescrito para este fim. Em indivíduos idosos, tem sido sugerido que o TR é capaz de aprimorar a capacidade aeróbia; entretanto, a temática é controversa. O objetivo do presente estudo foi verificar os efeitos do treinamento resistido sobre índices da capacidade aeróbia de mulheres idosas. METODOLOGIA: Participaram voluntariamente 50 idosas, as quais foram distribuídas em dois possíveis grupos: grupo controle (GC - n = 25; idade média 68,00 ± 6,38 e grupo treinamento (GT - n = 25; idade média 68,04 ± 6,78 anos. Todas as participantes realizaram teste ergoespirométrico em esteira conduzido até a exaustão voluntária antes e após a intervenção. O GT foi submetido a um programa de TR para os principais grupos musculares três vezes por semana durante um período de 24 semanas. Ao GC foi solicitado que mantivessem suas rotinas habituais. Split plot Anova foi utilizada para verificar possíveis diferenças intra e intergrupos. RESULTADOS: Foi observado que o GT apresentou aumento significativo nas variáveis tempo de teste e VO2, tanto no momento do LA como no momento da exaustão. No GC nenhuma das variáveis dependentes sofreu alteração significativa. CONCLUSÃO: Conclui-se que 24 semanas de TR é capaz de promover melhora no desempenho durante teste de esforço cardiopulmonar em uma amostra de mulheres idosas. Futuros estudos serão importantes para elucidar os mecanismos responsáveis por tais adaptações.INTRODUCTION AND OBJECTIVES: Peak oxygen uptake (VO2 peak and anaerobic threshold (AT have been widely accepted as important predictors of aerobic fitness. Traditionally, aerobic training is viewed as

  10. Efeitos do ultra-som terapêutico sobre o crescimento longitudinal do fêmur e da tíbia em ratos Effects of therapeutic ultrasound on longitudinal growth of the femur and tibia in rats

    Directory of Open Access Journals (Sweden)

    Alfredo Alcantara Barreto

    2011-01-01

    Full Text Available OBJETIVO: Estudar efeitos do ultra-som terapêutico sobre o crescimento do fêmur e da tíbia, em ratos jovens. MÉTODO: Ratus norvegicus com quatro semanas de vida, machos, totalizando 115 animais, divididos em quatro grupos, foram submetidos ao ultra-som terapêutico (0,8 MHz, cabeçote fixo, pulso contínuo, por dez minutos, durante dez dias, na face medial do joelho direito, nas potências de 0,0 W/cm2 (grupo controle, 0,5 W/cm2 (grupo G2, 1,0 W/cm2 (grupo G3, e 1,5 W/cm2 (grupo G4. Lâminas histológicas da epífise, placa de crescimento e metáfise e as medidas dos comprimentos do fêmur e da tíbia foram estudadas na sexta, décima terceira e vigésima sexta semanas de vida. Os dados foram submetidos à análise de variância - fatorial inteiramente aleatorizado. RESULTADO: Nenhuma alteração estatística do crescimento ósseo foi estabelecida entre quaisquer dos três grupos tratados e o grupo controle. Entretanto, alterações sugestivas de diminuição do crescimento do fêmur e da tíbia de G4 em relação a G2 e G3, foram evidenciadas. No grupo G4 alterações histopatológicas como necroses celulares e neoformação óssea, pós-necrose, foram encontradas. CONCLUSÃO: Quando comparados os grupos tratados com o grupo controle, não há evidência estatística de estímulo ou inibição ao crescimento ósseo pela aplicação do ultra-som terapêutico. Nível de Evidência: Nível II, estudo coorte transversal.OBJECTIVES: To determine the effects of ultrasound therapy on the femur and tibia growth in young rats. METHOD: Four-week-old male Ratus Norvegicus totaling 115 animals, divided into four groups, were submitted to ultrasound therapy (0.8 MHz, fixed tube head, continuous pulse, for 10 minutes, once a day, ten times on the medial face of the right knee, with powers of 0.0 W/cm2 (group G1, 0.5 W/cm2 (group G2, 1.0 W/cm2 (group G3, and 1.5 W/cm2 (group G4. Histological slides of the epiphysis, growth plate and metaphysis and the

  11. Estabilidade aeróbia de silagens de capim-mombaça tratadas com Lactobacillus buchneri Aerobic stability of mombaça grass silages treated with Lactobacillus buchneri

    Directory of Open Access Journals (Sweden)

    Carla Luiza da Silva Ávila

    2009-05-01

    Full Text Available Objetivou-se avaliar o efeito da adição de duas cepas de Lactobacillus buchneri sobre a estabilidade aeróbia de silagens de capim-mombaça. O experimento foi conduzido em delineamento inteiramente casualizado com três repetições, em esquema de parcelas subdivididas no tempo, de modo que os tratamentos (silagens sem inoculantes e com inoculante experimental e comercial foram aleatorizados nas parcelas e os tempos de avaliação aeróbia das silagens (0, 2, 8 ou 10 dias após a abertura dos silos nas subparcelas. Após 90 dias de armazenamento, os silos foram abertos e amostras de aproximadamente 2,5 kg foram retiradas para avaliação da estabilidade aeróbia com base na temperatura de cada amostra. As mudanças químicas e microbiológicas foram avaliadas. Após abertura dos silos, verificou-se aumento nas populações de bactérias do ácido lático, leveduras e fungos filamentosos. Houve aumento nos valores de pH resultante da redução da concentração dos ácidos orgnicos e de aumentos dos teores de matéria seca e proteína bruta. A adição de L. buchneri às silagens melhorou sua estabilidade, enquanto a silagem sem inoculante apresentou estabilidade de 55 horas. As silagens inoculadas não ultrapassaram essa temperatura limite em um período de 10 dias. A melhoria da estabilidade foi ocasionada pela associação de altas concentrações de cido acético ao ácido propiônico e pela menor concentração de ácido lático no momento de abertura, o que inibiu a proliferação de fungos filamentosos e leveduras após abertura dos silos.This study aimed to evaluate the effect of the addition of two L. buchneri strains on the aerobic stability of the Mombaça grass silages. The experiment was carried out in a completely randomized design with three replicates in split-plot in time scheme, so that the treatments (silages without inoculant and with experimental or commercial inoculants were randomized on plot and in times of aerobic

  12. Aerobic stability of triticale silage in single culture or in mixtures with oat and/or legumes Estabilidade aeróbia de silagens de triticale em cultivo exclusivo ou em misturas com aveia e/ou leguminosas

    Directory of Open Access Journals (Sweden)

    Valter Harry Bumbieris Junior

    2010-11-01

    Full Text Available The objective of the present study was to evaluate the aerobic stability and losses during the fermentation process of triticale silages in single crop or in mixtures with oats and/or legumes. The following crops were used for silage production: triticale (X. Triticosecale Wittimack, triticale intercropped with forage pea (Pisum arvense and triticale intercropped with oats (Avena strigosa Schreb, forage pea and vetch (Vicia sativa. The dry matter content and its recovery did not differ among the silages. Buffer capacity was higher for tricale silage intercropped with oats, forage pea and vetch(88.67 m eq. NaOH/100 g DM followed by triticale intercropped with forage pea (80.80 m eq. NaOH/100 g DM. Electric conductivity values were higher in the intercropped triticale silages. Triticale silage presented the lowest temperatures observed in the silos, and the silages of intercropped triticale silages presented higher heat retention and higher pH values. Silage of triticale intercropped with oats and legumes presented lower aerobic stability but it did not reduce the aerobic stability of the total feed. Dry matter recovery during storage and in stability evaluations in aerobiosis is similar among the silages.O objetivo neste trabalho foi avaliar a estabilidade aeróbia e as perdas durante o processo de fermentação de silagens de triticale em cultivo exclusivo ou em misturas com aveia e/ou leguminosas. As culturas utilizadas para produção das silagens foram: triticale (X. Triticosecale Wittimack; triticale em consórcio com ervilha-forrageira (Pisum arvense; e triticale em consórcio com aveia (Avena strigosa Schreb, ervilha-forrageira e ervilhaca (Vicia sativa. O teor de matéria seca e a recuperação de matéria seca não diferiram entre as silagens. A capacidade tampão foi maior para a silagem de triticale cultivado em consórcio com aveia, ervilha-forrageira e ervilhaca (88,67 m eq. NaOH/100 g de MS, seguida da silagem de triticale cultivado

  13. Trial endpoints for drug approval in oncology: Chemoprevention.

    Science.gov (United States)

    Beitz, J

    2001-04-01

    As with other drugs, new drug applications for marketing approval of chemopreventive drugs must include data from adequate and well-controlled clinical trials that demonstrate effectiveness and safety for the intended use. This article summarizes the regulatory requirements for traditional marketing approval, as well as for approval under the accelerated approval regulations. Unlike traditional approval, accelerated approval is based on a surrogate endpoint that is reasonably likely to predict clinical benefit. Discussions with the Food and Drug Administration (FDA) regarding the validity of trial endpoints that may serve as surrogates for clinical benefit for accelerated approval should take place as early as possible in drug development. Meetings with the FDA to discuss these issues may be requested throughout the clinical development of a new drug.

  14. 76 FR 23615 - Notice of Submission of Proposed Information Collection to OMB; Quality Control Requirements for...

    Science.gov (United States)

    2011-04-27

    ... Proposed Information Collection to OMB; Quality Control Requirements for Direct Endorsement Lenders AGENCY... proposal. This information is collected from Direct Endorsement lenders in order to meet FHA's quality... Lenders. OMB Approval Number: 2502-Pending. Form Numbers: None. Description of the Need for the...

  15. Comparação da potência anaeróbia entre as posições táticas em jogadores de futebol: estudo retrospectivo

    Directory of Open Access Journals (Sweden)

    Tiago Cetolin

    2013-05-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2013v15n4p507 O objetivo do estudo foi comparar a Potência anaeróbia máxima (Pmáx; Potência anaeróbia média (Pmed e índice de fadiga (IF entre atletas de diferentes posições táticas no futebol. Para isso, 248 atletas profissionais de futebol de campo (25,8±1,72 anos, 77,52±4,90 Kg e 178,48±5,63 cm, pertencentes a 1ª e 2ª divisão do estado do Rio Grande do Sul, avaliados durante o período de 1999-2010, divididos em cinco posições táticas: goleiros (GO (n=28, laterais (LA (n=35, zagueiros (ZA (n=54, meio-campistas (MC (n=81 e atacantes (AT (n=50. Os atletas executaram o RAST test para determinar a Pmáx, Pmed e IF. Foi utilizada a ANOVA One Way e post hoc de Tukey adotando-se o valor de significância de p<0,05. Diferenças significativas para a Pmáx (p<0,05 dos LA comparadas aos GO, ZAe MC; da Pmed dos LA para os GO, ZA e MC e dos AT e MC em relação aos GO(p<0,05. Na potência relativa de cada sprint, houve manutenção durante o 1º e 2º sprint entre as posições, exceto os MC e durante o 5º e 6º sprint, independente da posição, não houve decréscimo do desempenho de potência. Visto que foram encontradas diferenças significativas de Pmáx e da Pmed, dos LA em relação aos GO, ZA e MC, concluímos que esta evidência confirma que atletas de diferentes posições táticas apresentam variação quanto às características de suas ações.

  16. Innovating by developing new uses of already-approved drugs: trends in the marketing approval of supplemental indications.

    Science.gov (United States)

    DiMasi, Joseph A

    2013-06-01

    Much of the literature on trends and factors affecting biopharmaceutical innovation has focused overwhelmingly on the development and approval of never-before approved drugs and biologics. Little attention has been paid to new uses for already-approved compounds, which can be an important form of innovation. This paper aimed to determine and analyze recent trends in the number and type of new or modified US indication approvals for drugs and biologics. We also examine regulatory approval-phase times for new-use efficacy supplements and compare them to approval-phase times for original-use approvals over the same period. We developed a data set of efficacy supplements approved by the US Food and Drug Administration (FDA) from 1998 to 2011 that includes information on the type, approval-phase time (time from submission to the FDA of an application for marketing approval to approval of the application), and FDA therapeutic-significance rating for the approved application, which we obtained from an FDA Web site. This data set was merged with a Tufts Center for the Study of Drug Development (CSDD) data set of US new drug and biologics approvals. We developed descriptive statistics on trends in the number and type of new-use efficacy supplements, on US regulatory approval-phase times for the supplements, and on original new drug and biologics approvals over the study period and for the time from original- to new-use approval. The total number of new-use efficacy-supplement approvals did not exhibit a marked trend, but the number of new pediatric-indication approvals increased substantially. Approval-phase times for new-use supplements varied by therapeutic class and FDA therapeutic-significance rating. Mean approval-phase times were highest for central nervous system compounds (13.8 months) and lowest for antineoplastics (8.9 months). The mean time from original to supplement approval was substantially longer for new pediatric indications than for other new uses. Mean

  17. 75 FR 50711 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Final Approval and...

    Science.gov (United States)

    2010-08-17

    ... operations under OAC 3745-21-09(U)(2)(f). For administrative convenience, in a separate rulemaking published... conditional approval of portions of OAC rule 3745-21-09. You can learn more information about the rule... implementing a Federal Standard. National Technology Transfer Advancement Act In reviewing state submissions...

  18. 75 FR 54215 - Agency Request for Approval of a Previously Approved Information Collection(s): Uniform...

    Science.gov (United States)

    2010-09-03

    ... about our intention to request Office of Management and Budget (OMB) approval to renew a previously... because of management and oversight responsibilities of the agency imposed by OMB Circular 2 CFR 215 (A... Department has terminated Financial Status Report (SF-269 and SF-269A) and Federal Cash Transactions Report...

  19. 78 FR 63937 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

    Science.gov (United States)

    2013-10-25

    ... Quality Plans for Designated Facilities and Pollutants, State of Iowa; Control of Emissions From Existing Hospital/ Medical/Infectious Waste Incinerator Units, Negative Declaration and 111(d) Plan Rescission... existing state air quality rules, approve an exemption from constructing permitting for engines used in...

  20. 78 FR 63887 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

    Science.gov (United States)

    2013-10-25

    ... Quality Plans for Designated Facilities and Pollutants, State of Iowa; Control of Emissions From Existing Hospital/ Medical/Infectious Waste Incinerator Units, Negative Declaration and 111(d) Plan Rescission... quality rules, approve an exemption from constructing permitting for engines used in periodic pipeline...

  1. 77 FR 26474 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Approval of 2011 Consent...

    Science.gov (United States)

    2012-05-04

    ... Department of the Environment (MDE). These revisions approve specific provisions of a 2011 Consent Decree between MDE and GenOn to reduce particulate matter (PM), sulfur oxides (SO X ), and nitrogen oxides (NO X....regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system, which means EPA...

  2. 77 FR 26438 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Approval of 2011 Consent...

    Science.gov (United States)

    2012-05-04

    ... (MDE) pertaining to the GenOn Chalk Point Generating Station (Chalk Point). These revisions approve specific provisions of a 2011 Consent Decree between MDE and GenOn to reduce particulate matter (PM... www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system...

  3. 77 FR 59335 - Approval and Promulgation of Implementation Plans; North Carolina: Approval of Rocky Mount Motor...

    Science.gov (United States)

    2012-09-27

    ... account for any future changes to the emission model, projection model and other input data. \\2\\ A safety... changes in the emissions model and vehicle miles traveled (VMT) projection model. EPA is approving this... Regional Office's official hours of business are Monday through Friday, 8:30 to 4:30, excluding federal...

  4. Criteria for approving equipment for continued operation

    International Nuclear Information System (INIS)

    Narayanan, T.V.

    1993-01-01

    In May 1988, the Pressure Vessel Research Committee (PVRC) of the Welding Research Council (WRC) initiated four projects in support of ASME's efforts to develop Codes and Standards for life prediction and life extension of nuclear and fossil power plant components. These projects are: (1) Criteria for Approving Equipment for Continued Operation (2) Guidelines and Procedures for Evaluating Piping for Continued Operation (3) Nondestructive Evaluation of Material Degradation (4) Operation and Maintenance History and Life Cycle Management. The PVRC awarded a contract to Foster Wheeler Development Corporation to undertake the first of these projects. The specific objective was to develop a program plan that will lead to development of ''Criteria for Approving Equipment for Continued Operation.'' The program is divided into the following four tasks: Task 1: Literature Search; Task 2: Telephone Interview and Consultation; Task 3: Program Plan Development; Task 4: Preparation of a Summary Report. This report is in fulfillment of the above project. As part of this study, the author reviewed about 145 reports, papers and books relating to various aspects of life extension. Various experts were also consulted who are involved in EPRI, NRC, ASME, PVRC, MPC, and utility studies as well as other research projects. The conclusions and recommendations for Code-related activities are summarized

  5. GESSO SINTÉTICO E PINOS TRANSCORTICAIS NA REDUÇÃO DE FRATURA DE TÍBIA EM UMA BEZERRA FIBERGLASS CAST AND TRANSCORTICAL PINS IN TIBIAL FRACTURE REDUCTION IN A CALF

    Directory of Open Access Journals (Sweden)

    Edivaldo Aparecido Nunes Martins

    2001-02-01

    Full Text Available Relata-se um caso de fratura de tíbia em uma bezerra de sete meses de idade, 200kg de peso, apresentando fratura fechada, cominutiva em diáfise. A fixação externa foi preferida como método de imobilização óssea, utilizando-se pinos transcorticais e gesso sintético. Obteve-se eficiente imobilização da fratura, com rápida recuperação do animal, dispendendo-se pouco tempo para o pós-operatório (52 dias. A técnica demonstrou ser de fácil realização e passível de ser executada a campo.A case of tibial fracture in a 7-month-old calf is reported, with closed comminuted diaphysial fracture. It has been given preference to external fixation as means of fracture immobilization, and transcortical pins and fiberglass cast have been used. Effective immobilization of the fracture and fast recovering of the animal as well as less time consuming toward the postoperative have been obtained. This technique has showed feasible to be done in the field.

  6. Applying for ethical approval for research: the main issues.

    Science.gov (United States)

    Gelling, Leslie

    2016-01-13

    The need to obtain research ethical approval is common to all research involving human participants. This approval must be obtained before research participants can be approached and before data collection can begin. The process of ethical review is one way that research participants can be confident that possible risks have been considered, minimised and deemed acceptable. This article outlines some of the main issues researchers should consider when planning an application for research ethical approval by answering the following six questions: 'Do I need research ethical approval?', 'How many applications will I need to make?', 'Where should I apply for research ethical approval?', 'What do I need to include in my application?', 'What do research ethics committees look for?' and 'What other approvals might I need?' Answering these questions will enable researchers to navigate the ethical review process.

  7. 40 CFR 256.04 - State plan approval, financial assistance.

    Science.gov (United States)

    2010-07-01

    ... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose, General Requirements, Definitions § 256.04 State plan approval, financial assistance. (a) The...

  8. Approved Air Quality Implementation Plans in Region 10

    Science.gov (United States)

    Landing page for information about EPA-approved air quality State Implementation Plans (SIPs), Tribal Implementation Plans (TIPs), and Federal Implementation Plans (FIPs) in Alaska, Idaho, Oregon, Washington.

  9. ELECTRONIC COMPLIANCE AND APPROVAL PROJECT (ECAP)

    Energy Technology Data Exchange (ETDEWEB)

    Hope Morgan; Richard A. Varela; Deborah LaHood; Susan Cisco; Mary Ann Benavides; Donna Burks

    2002-11-01

    The Texas Railroad Commission (RRC), working in partnership with the United States Department of Energy and the oil and gas industry it regulates, is implementing a strategy for improving efficiency in regulations and significantly reducing administrative operating costs through the Electronic Compliance and Approval Process (ECAP). The project will streamline regulatory compliance and reporting by providing the ability to electronically submit, process, and query oil and gas applications and reports through the Internet-based ECAP system. Implementation of an ECAP drilling permit pilot project began September 1999 after funding resources were secured--a $700,000 grant from the U.S. Department of Energy and an appropriation of $1.4 million from the Texas Legislature. The pilot project involves creating the ability to file, review, and approve a well's drilling permit application through a completely electronic process. The pilot project solution will ultimately provide the infrastructure, technology, and electronic modules to enable the filing of all compliance permits and performance reports through the internet from a desktop computer. The pilot project was conducted in three phases. The first phase, implemented May 2000, provided the infrastructure that allows the electronic filing and approval of simple drilling permit applications, associated fees, and attachments. The official ''roll-out'' of ECAP and the first electronically filed drilling permit application occurred on May 11, 2000 in Dallas in conjunction with an Internet Workshop sponsored by the Petroleum Technology Transfer Council. After the completion of Phase I, the ECAP team conducted an extensive review of progress to date and analyzed requirements and opportunities for future steps. The technical team identified core infrastructure modifications that would facilitate and better support future development and expansion of the ECAP system and work began on database structure

  10. Patient-Centered Drug Approval: The Role of Patient Advocacy in the Drug Approval Process.

    Science.gov (United States)

    Mattingly, T Joseph; Simoni-Wastila, Linda

    2017-10-01

    Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential. Although the gold standard for establishing safety and efficacy through randomized controlled trials has been in place for more than 50 years, it poses several limitations for rare disorders where patient recruitment for traditional clinical trials is a major barrier. Organized efforts by patient advocacy groups to help patients with rare diseases access investigational therapy have had a legislative and regulatory effect. After approval by the FDA, patient access to therapy may still be limited by cost. A managed care organization (MCO) with the fiduciary responsibility of managing the health of a population must weigh coverage decisions for costly therapies with questionable effectiveness against alternatives within the constraint of a finite budget. Even when the FDA deems a drug safe and effective, an MCO may determine that the drug should only be made available at a tier level where out-of-pocket costs are still too high for many patients. This limitation of availability may be due to cost, other treatment alternatives, or outcomes from existing clinical evidence. However, if the MCO makes a costly new treatment for a rare disease readily available, it may temporarily satisfy a small contingency at the cost of all of its members. This article examines the risks and benefits of patient-centered drug approval and the potential economic effect of patient-centered drug approval on population health. There is no funding to disclose. Mattingly

  11. Consumer approval of irradiated meat still tentative

    International Nuclear Information System (INIS)

    Hollingsworth, P.

    1998-01-01

    Although the FDA has approved irradiation of red meat, consumers may not be so accepting of the use of this technology. Irradiation is a process used to improve food safety in food products susceptible to disease-causing microorganisms. The red meat ruling was widely praised by federal officials and food industry leaders, but consumers seem less sure. Indeed, on the night of the red meat announcement last December, CBS Evening News reported that over 70 percent of U.S. consumers would not knowingly eat irradiated food. There is hope, however, as a study by the Center for Consumer Research at the University of California, Davis, revealed that consumer interest in buying irradiated food can be substantially improved by providing consumers with information, thereby enabling them to see the benefits and to overcome the myths of irradiation

  12. HyApproval - Handbook for the approval of hydrogen refuelling stations - First preliminary achievements

    Energy Technology Data Exchange (ETDEWEB)

    Wurster, R.; Vandendungen, G.; Guichard, J.; Molag, M.; Barron, J.; Reijalt, M.; Hill, H.J.; Landinger, H.

    2007-05-15

    The EU-funded project HyApproval [www.hyapproval.org] aims at developing a universal Handbook to facilitate the approval process of Hydrogen Refuelling Stations (HRS) in Europe. The main goal of the HyApproval partnership with 22 partners from Europe and one each from China, Japan and the USA is to provide a Handbook of technical and regulatory requirements to assist authorisation officials, companies and organisations in the safe implementation and operation of HRS. Achievements during the first 15 months: analyses of HRS technology concepts and of equipment and safety distances/ Intermediate Design Paper/ Regulations, Codes and Standards (RCS) review and comparison/ first Handbook draft and first review sessions with HySafe experts/ safety matrix/ identification of accident scenarios/ agreement on safety documentation/ critical review of reliability data from collections and risk studies/ risk assessment (RA) criteria definition and RA/ matrix of acceptability and awareness levels/ database of Fire Associations and First Responders/ calendar of hydrogen events/ general description of CGH{sub 2} interfaces. (au)

  13. Waste Feed Delivery Environmental Permits and Approvals Plan

    Energy Technology Data Exchange (ETDEWEB)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  14. 14 CFR 21.8 - Approval of articles.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to be...

  15. Waste Feed Delivery Environmental Permits and Approvals Plan

    International Nuclear Information System (INIS)

    TOLLEFSON, K.S.

    2000-01-01

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches

  16. Hyapproval : final handbook for approval of hydrogen refuelling stations

    NARCIS (Netherlands)

    Wurster, R.; Landinger, H.; Machens, C.; Allidières, L.; Molag, M.; Barron, J.; Reijalt, M.; Hill, H.J.

    2006-01-01

    HyApproval is an EC co-financed Specific Targeted Research Project (STREP) to develop a Handbook facilitating the approval of Hydrogen Refuelling Stations (HRS). The project, started in October 2005, will be performed over 24 months by a balanced partnership including 25 partners from industry, SMEs

  17. 75 FR 71187 - Wolverine Bank, MI; Approval of Conversion Application

    Science.gov (United States)

    2010-11-22

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-55: OTS Nos. 02620 and H4753] Wolverine Bank, MI; Approval of Conversion Application Notice is hereby given that on November 12, 2010, the Office of Thrift Supervision approved the application of Wolverine Bank, Midland, Michigan, to convert to...

  18. 12 CFR 563g.19 - Approval of the security.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Approval of the security. 563g.19 Section 563g.19 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.19 Approval of the security. Any securities of a savings association which are not exempt under...

  19. 5 CFR 6601.102 - Prior approval for outside employment.

    Science.gov (United States)

    2010-01-01

    ... approval for outside employment. (a) Before engaging in any outside employment with a prohibited source... (including the name of the person, group or other organization for whom the work is to be performed), and a... activity, and, if so, how much. (b) Approval shall be granted only upon determination that the outside...

  20. 38 CFR 21.9765 - Program of education approval.

    Science.gov (United States)

    2010-07-01

    ... education offered by an institution of higher learning if that program of education is approved under 38 U.S... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Program of education... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-9/11 GI Bill Approval of Programs of Education § 21...

  1. 47 CFR 400.5 - Approval and award.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Approval and award. 400.5 Section 400.5 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE, AND NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION E-911 GRANT PROGRAM § 400.5 Approval...

  2. [Reporting ethics board approval in German medical theses and journals].

    Science.gov (United States)

    Zenz, Michael; Zenz, Julia; Grieger, Maximilian

    2018-06-05

    Since 1975, the Declaration of Helsinki of the World Medical Association (WMA) has clearly required ethics committee approval for research into humans. Nevertheless, this Declaration is violated quite often. As many English-language publications have addressed the theme of ethics board approval in theses and other published works, it is now to be investigated in Germany for the first time.From 2013 to 2014, a total of 1,482 medical theses at four selected universities in addition to three German-language scientific journals were reviewed. In 543 theses, reference to ethics approval would have been required according to the criteria of the Declaration of Helsinki.However, ethics approval was stated in only 58.7% of cases, and even less frequently if the prevailing doctoral regulations or instructions did not refer to the necessity of obtaining ethics approval. Theses on pediatrics mentioned ethics approval most frequently (78.6%), whereas the proportion of surgical papers was the lowest (34.9%). Among the journals, Der Nervenarzt mentioned ethics approval most frequently (59.4%) and Der Chirurg least frequently (30%).Our results point to significant deficits in mentioning ethics approval in medical theses and publications. These deficits could easily be compensated for by a thorough approach of the referees of doctoral regulations and by journal reviewers and editors.

  3. 5 CFR 1320.16 - Delegation of approval authority.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Delegation of approval authority. 1320.16... PAPERWORK BURDENS ON THE PUBLIC § 1320.16 Delegation of approval authority. (a) OMB may, after complying... delegation of review authority shall be made unless the agency demonstrates to OMB that the Senior Official...

  4. Establishment approval in international trade of animal products

    NARCIS (Netherlands)

    Rau, M.L.; Ge, L.; Valeeva, N.I.; Wagenberg, van C.P.A.

    2012-01-01

    This report provides an overview of different approaches of establishment approval as well as its implementation and organisation in international agrifood trade. The focus is on animal products as establishment approval is particularly used for exporting these products. Based on trade data, 8

  5. 32 CFR 736.7 - Approval by the Attorney General.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Approval by the Attorney General. 736.7 Section..., PATENTS, AND CONTRACTS DISPOSITION OF PROPERTY § 736.7 Approval by the Attorney General. Prior to the... inventions, irrespective of cost, the Department of the Navy must notify the Attorney General of the proposed...

  6. 7 CFR 1735.62 - Approval of acquisitions and mergers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Approval of acquisitions and mergers. 1735.62 Section 1735.62 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Mortgage Controls on Acquisitions and Mergers § 1735.62 Approval of acquisitions and mergers. (a) If a...

  7. 14 CFR 21.609 - Approval for deviation.

    Science.gov (United States)

    2010-01-01

    ... deviation. (a) Each manufacturer who requests approval to deviate from any performance standard of a TSO shall show that the standards from which a deviation is requested are compensated for by factors or... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval for deviation. 21.609 Section 21...

  8. 30 CFR 75.600-1 - Approved cables; flame resistance.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approved cables; flame resistance. 75.600-1 Section 75.600-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE... cables; flame resistance. Cables shall be accepted or approved by MSHA as flame resistant. [57 FR 61223...

  9. 50 CFR 37.22 - Approval of exploration plan.

    Science.gov (United States)

    2010-10-01

    ... § 37.21(b), the Regional Director shall promptly publish notice of the application and text of the plan... exploration plan shall be approved by the Regional Director if he determines that it satisfies the....11(b), or minimize adverse impacts on subsistence uses, the Regional Director may approve or...

  10. 13 CFR 302.18 - Post-approval requirements.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Post-approval requirements. 302.18 Section 302.18 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... Federal cost principles (collectively, “Post-Approval Requirements”). A Recipient's failure to comply with...

  11. Dabrafenib Plus Trametinib Approved for Melanoma, Thyroid Cancer

    Science.gov (United States)

    FDA recently approved the combination of dabrafenib (Taflinar) and trametinib (Mekinist) to treat some patients with melanoma and anaplastic thyroid cancer whose tumors have a mutation in the BRAF gene. As this Cancer Currents blog post explains, this is the first treatment approved specifically for anaplastic thyroid

  12. 45 CFR 95.611 - Prior approval conditions.

    Science.gov (United States)

    2010-10-01

    ... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GENERAL ADMINISTRATION... for Department approval, signed by the appropriate State official, to the Director, Administration for... of procurement activities beyond that approved in the APD; (D) A change in system concept, or a...

  13. 75 FR 36301 - Review and Approval of Projects

    Science.gov (United States)

    2010-06-25

    ... SUSQUEHANNA RIVER BASIN COMMISSION 18 CFR Parts 806 and 808 Review and Approval of Projects AGENCY... document contains proposed rules that would amend the project review regulations of the Susquehanna River... the scope of withdrawals requiring review and approval; improve notice procedures for all project...

  14. 44 CFR 78.9 - Planning grant approval process.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION ASSISTANCE § 78.9 Planning grant approval process. The State POC will evaluate and approve applications for Planning Grants. Funds will be provided only for the flood portion of any mitigation plan, and...

  15. 38 CFR 21.4263 - Approval of flight training courses.

    Science.gov (United States)

    2010-07-01

    ..., and aircraft identification number; (xi) An accounts receivable ledger; (xii) Individual instructor... higher learning are the only entities that can offer flight courses. A State approving agency may approve a flight course only if a flight school or an institution of higher learning offers the course. A...

  16. Editorial: Ethics approval: responsibilities of journal editors, authors ...

    African Journals Online (AJOL)

    Meaningful progress of medicine depends on research that must ultimately involve human subjects. Obtaining ethical approval therefore, especially in medical sciences, should be a moral reflex for researchers. This unfortunately is not the case, with numerous researchers bypassing the ethics approval procedure, or simply ...

  17. 30 CFR 90.206 - Approved sampling devices; equivalent concentrations.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approved sampling devices; equivalent... LABOR COAL MINE SAFETY AND HEALTH MANDATORY HEALTH STANDARDS-COAL MINERS WHO HAVE EVIDENCE OF THE DEVELOPMENT OF PNEUMOCONIOSIS Sampling Procedures § 90.206 Approved sampling devices; equivalent...

  18. 34 CFR 668.144 - Application for test approval.

    Science.gov (United States)

    2010-07-01

    ... quantitative skills; (9) If a test has been revised from the most recent edition approved by the Secretary, an... Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY... inquiries; (3) Each edition and form of the test for which the publisher requests approval; (4) The...

  19. 40 CFR 80.93 - Individual baseline submission and approval.

    Science.gov (United States)

    2010-07-01

    ... or methodology deviations will be approved or disapproved by the Director of the Office of Mobile... approval by the Director of the Office of Mobile Sources, or designee. (ii) Petitions, “showings,” and..., business address and business phone number of the company contact; (iii) Address and physical location of...

  20. 7 CFR 1703.121 - Approved purposes for grants.

    Science.gov (United States)

    2010-01-01

    ... Approved purposes for grants. For distance learning and telemedicine projects, grants shall finance only... studies relating to the establishment or expansion of the phase of the project that is being financed with... initial capital assets associated with the project. The following are approved grant purposes: (a...

  1. 48 CFR 1819.7203 - Mentor approval process.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mentor approval process... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS NASA Mentor-Protégé Program 1819.7203 Mentor approval process. (a) An entity seeking to participate as a mentor must apply to the NASA Headquarters...

  2. 5 CFR 7401.102 - Prior approval for outside employment.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE MERIT SYSTEMS PROTECTION BOARD § 7401.102 Prior approval... written approval from the employee's supervisor and the concurrence of the Designated Agency Ethics... name of the employer or organization; (ii) The nature of the legal activity or other work to be...

  3. 42 CFR 102.73 - Approval of benefits.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Approval of benefits. 102.73 Section 102.73 Public... PROGRAM Secretarial Determinations § 102.73 Approval of benefits. When the Secretary has determined that benefits will be paid to a requester and has calculated the type and amount of such benefits, he will...

  4. 24 CFR 886.107 - Approval of applications.

    Science.gov (United States)

    2010-04-01

    ...) The Owner's Affirmative Fair Housing Marketing Plan is approvable. (b) The HUD-approved unit rents are... climatic or geological conditions or local codes are examples which may justify such variations. (d) A... neighborhood in a substantially adverse manner. Examples of such adverse effects are (1) substantial move-outs...

  5. 24 CFR 990.145 - Dwelling units with approved vacancies.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Dwelling units with approved vacancies. 990.145 Section 990.145 Housing and Urban Development Regulations Relating to Housing and Urban...; Computation of Eligible Unit Months § 990.145 Dwelling units with approved vacancies. (a) A PHA is eligible to...

  6. 2016 in review: FDA approvals of new molecular entities.

    Science.gov (United States)

    Griesenauer, Rebekah H; Kinch, Michael S

    2017-11-01

    An overview of drugs approved by FDA in 2016 reveals dramatic disruptions in long-term trends. The number of new molecular entities (NMEs) dropped, reflecting the lowest rate of small-molecule approvals observed in almost five decades. In addition, the pace of industry consolidation slowed substantially. The impact of mergers and acquisitions decreased the total number of organizations with past approval experience and continued research and development (R&D) activities to 102, divided evenly between more established pharmaceutical and newer biotechnology companies. Despite these substantial differences, the industry continued to pursue regulatory incentives, as evidenced by a continued increase in the fraction of NMEs approved using an orphan or priority designation, and almost all oncology drugs approved in 2016 utilized these mechanisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Charakterystyka etiologiczna udarów mózgu leczonych w Klinice Neurologii UM w Białymstoku z analizą czynników ryzyka

    Directory of Open Access Journals (Sweden)

    Anna Syta-Krzyżanowska

    2010-03-01

    Full Text Available Wstęp: W przeprowadzonych w Polsce badaniach epidemiologicznych stwierdzono utrzymujący się od kilkunastu lat wysoki współczynnik zapadalności na pierwszy w życiu udar mózgu, wzrastający wykładniczo z wiekiem oraz połączony z wciąż dużą śmiertelnością. Poznanie czynników ryzyka oraz wprowadzenie profilaktyki może istotnie zmniejszyć powyższe wskaźniki. Celem pracy było przeprowadzenie analizy epidemiologicznej pacjentów z udarem mózgu hospitalizowanych na Pododdziale Udarowym Kliniki Neurologii USK w Białymstoku. Uwzględniono w szczególności etiologię z czynnikami ryzyka oraz śmiertelnością w zależności od wieku i płci chorych. Materiał i metody: Rozpatrzono wszystkie przypadki pacjentów hospitalizowanych w Klinice Neurologii USK w Białymstoku z powodu udaru mózgu w ciągu pełnego roku kalendarzowego. Posłużono się ankietami prowadzonymi w ramach Narodowego Programu Profilaktyki i Leczenia Chorób Sercowo-Naczyniowych (POLKARD. Obliczenia statystyczne wykonywano przy użyciu programu Statistica w wersji 8.0. Wyniki: Przeanalizowano wyniki 408 pacjentów, w tym 185 (45,3% kobiet oraz 223 (54,7% mężczyzn z rozpoznanym: krwotokiem podpajęczynówkowym – 6,9%, krwotokiem śródmózgowym – 12,5% oraz udarem niedokrwiennym – 80,6%. Etiologię zatorową pochodzenia sercowego zdiagnozowano u 39,4%, zakrzep dużych naczyń u 35%, natomiast udar zatokowy u 11,6% pacjentów. Najczęstszym czynnikiem ryzyka udaru niedokrwiennego mózgu było nadciśnienie tętnicze (81,2%, następnie migotanie przedsionków i choroba niedokrwienna serca (38%. Zmarło 11,6% chorych z udarem niedokrwiennym mózgu oraz 21,5% z udarem krwotocznym. Średnia śmiertelność wyniosła 13,5%. Wnioski: Najczęstszym czynnikiem ryzyka udaru mózgu było nadciśnienie tętnicze, które szczególnie często współwystępowało z dodatkowym czynnikiem ryzyka udaru niedokrwiennego mózgu. Prowadzenie leczenia udaru mózgu w pododdzia

  8. Frakcja lipidowa i białkowa nasion konopi siewnych (C. sativa L. oraz jej korzystny wpływ na zdrowie człowieka = Lipid and protein fraction of hemp seed (C. sativa L. and its beneficial influence on human health

    Directory of Open Access Journals (Sweden)

    Grzegorz Dąbrowski

    2016-09-01

      Abstrakt Wprowadzenie i cel pracy: Konopie siewne wykorzystywane są od tysięcy lat do produkcji włókien oraz oleju z nasion. W ostatnim czasie nasiona tej rośliny wykorzystuje się także do produkcji izolatów i hydrolizatów białek. Celem niniejszej pracy jest opisanie składu frakcji tłuszczowej i białkowej nasion konopi siewnych oraz potencjału zdrowotnego oleju oraz izolatów i hydrolizatów białkowych pochodzących z tego surowca. Skrócony opis stanu wiedzy: Nasiona konopi są bogatym źródłem oleju oraz białka. Skład oleju jest korzystny z żywieniowego punktu widzenia z uwagi na duży udział niezbędnych nienasyconych kwasów tłuszczowych (NNKT oraz korzystne proporcje kwasów n-6/n-3. Olej konopny zawiera także duże ilości związków bioaktywnych, takich jak fitosterole, karotenoidy, polifenole i tokoferole. Białko konopi cechuje się dobrym składem aminokwasów oraz jest źródłem bioaktywnych peptydów o działaniu antyoksydacyjnym. Podsumowanie: Ze względu na zawartość oleju o korzystnym składzie kwasów tłuszczowych i wartościowego białka, nasiona konopi powinny być coraz częściej wprowadzane do codziennej diety. Słowa kluczowe: konopie siewne, NNKT, bioaktywne peptydy, tokoferole, fitosterole, polifenole, karotenoidy   Abstract Introduction and purpose: Hemp are used for thousands of years to obtain the fiber and seed oil. Recently, the hemp seeds are also used for the production of protein hydrolysates and isolates. The aim of this study is to describe the composition of the fat and protein fractions. In addition health benefits of the consumption of the oil  and protein hydrolysates and isolates will be described. Brief description of the state of the knoweledge: Hemp seeds are a rich source of oil and protein. The oil composition is beneficial from a nutritional point of view due to the high content of essential fatty acids (EFAs in the optimal ratio of n-6 / n-3. Hemp oil also contains large amounts of a

  9. Differences in Body Build and Physical Fitness of PE Students from the Faculty of Physical Education and Sport in Biała Podlaska in the Years 1989, 2004, and 2014

    Directory of Open Access Journals (Sweden)

    Saczuk Jerzy

    2016-12-01

    Full Text Available Introduction. In the current situation of the demographic decline and simultaneous tough competition on the educational market, the issues of not only teaching levels but also the competences and aptitudes of students themselves are raised more and more often. Therefore, this study sought to analyse differences in the body build and physical fitness of physical education (PE students from the Faculty of Physical Education and Sport in Biała Podlaska in the years 1989, 2004, and 2014. Material and methods. The material included the results of the anthropometric measurements and physical fitness tests of second-year students examined in 1989 (n = 111, 2004 (n = 181, and 2014 (n = 127. Martin and Saller’s technique was employed to measure anthropometric features necessary to establish body build types using the Heath-Carter method. Physical fitness was evaluated with the International Physical Fitness Test. Sample size (n, arithmetic mean (x̅, standard deviation (SD, and the T point scale were applied to assess the collected variables. Differences in the sizes of the analysed features between the groups were estimated with the use of ANOVA and the Newman-Keuls test. Results. The analysis revealed a constant increase in basic somatic features and endomorphy and a decrease in mesomorphy and physical fitness in male subjects. The ectomorphy of students examined in 2014 was at a level similar to that recorded in 1989. The pace of the described changes was different depending on the study period. Conclusions. Secular trends in body build and physical fitness observed in the study may stem from deterioration in the biological potential of youths or may result from lowering physical education entrance exam criteria at the university.

  10. Compostagem aeróbia conjugada de lodo de tanque séptico e resíduos sólidos vegetais Conjugated aerobic composting of septic tank sludge and vegetable solid waste

    Directory of Open Access Journals (Sweden)

    André Gustavo da Silva

    2008-12-01

    Full Text Available O lodo sanitário, principal subproduto do tratamento de esgotos, constitui um dos maiores problemas ambientais urbanos da atualidade. Em meio a este contexto, objetivou-se nesse estudo avaliar o processo da compostagem conjugada de lodo de tanque séptico (LS e resíduos sólidos vegetais (RV e determinar a importância da temperatura para o processo de sanitização do substrato tratado. O experimento, inteiramente casualizado com três tratamentos e três repetições, consistiu de nove reatores aeróbios com 100 litros de capacidade. Os resíduos foram utilizados nas seguintes proporções - T1: 100% RV; T2: 5% LS + 95% RV; T3: 10% LS + 90% RV. A compostagem aeróbia conjugada mostrou ser uma alternativa viável para destruição de ovos de helminto e estabilização dos resíduos, sendo fundamentais para tal, a temperatura, o pH e as relações ecológicas presentes nos reatores.The sanitary sludge, principal byproduct of sewage treatment, constitutes one of the major municipal environmental problems of the present time. The present study was aimed to evaluate the composting of septic tank sludge (SS and vegetable solid waste (VW and to determine the importance of the temperature for the process of sanitization of the treated substrate. The experiment, entirely randomized with three treatments and three repetitions, constituted of nine aerobic reactors with 100 L capacity. The proportions of the wastes utilized were T1: 100%VW; T2: 5%SS + 95%VW; T3: 10%SS + 90%VW. The conjugated composting showed to be a feasible alternative for destruction of helminth eggs and stabilization of the wastes. The temperature, pH and ecological relations present in the reactors were fundamental for this purpose.

  11. 13 CFR 400.201 - Eligible Lender.

    Science.gov (United States)

    2010-01-01

    ... Board for a Guarantee of a loan must be: (1) A banking institution, such as a commercial bank or trust... investment institution, such as an investment bank, commercial finance company, or insurance company, that is currently engaged in commercial lending in the normal course of its business. (b)(1) If more than one...

  12. 40 CFR 281.39 - Lender liability.

    Science.gov (United States)

    2010-07-01

    ... management of the UST or UST system as defined under § 280.210 of this chapter, and who does not engage in petroleum production, refining, and marketing as defined under § 280.200(b) of this chapter is not: (A) An..., provided the holder is not in control of or does not have responsibility for the daily operation of the UST...

  13. Environmental approvals in New Brunswick : economic considerations

    Energy Technology Data Exchange (ETDEWEB)

    Marrack, C.; Maitland, R. [Suez Renewable Energy North America, Houston, TX (United States)

    2008-07-01

    This presentation provided a timeline of economic considerations related to New Brunswick's regulatory approval process for wind power developments. The economics of wind power projects require careful consideration during the initial planning phases, as it is not yet known if projects are viable. Spending in the early stages of a project should therefore be limited to items that focus on components of the environmental impact assessment (EIA) process that include establishing a relationship with First Nations groups in the area, and conducting seasonal bird studies. Economic considerations change when project viability is confirmed, and developers can then progress to conducting traditional knowledge studies and further seasonal bird studies. Baseline information studies should be reviewed, and biophysical surveys should involve the identification of any wetlands, sensitive areas, and rare plants. Archaeology studies are also required by the provincial government, as well as bat studies to determine if the site has a resident population of bats. Public and stakeholder consultations and open houses should then be held with an adequate time-frame for the submission of questions and concerns and the development of mitigation strategies. Project viability should be confirmed before power purchase agreements (PPAs) are signed. After PPAs are signed, the largest economic consideration is the schedule-related risk associated with legal and financial problems. It was concluded that noise impact, visual impact, and socioeconomic assessments and studies can be conducted after the PPA is secured. tabs., figs.

  14. Space Program Annual Report, For Approval

    International Nuclear Information System (INIS)

    TM Schaefer

    2004-01-01

    Knolls Atomic Power Laboratory (KAPL) (lead) has been requested by the Reference to create an unclassified report on the Prometheus Program's Jupiter Icy Moons Orbiter (JIMO) mission. This report is expected to be issued annually and be similar in level of content and scope to the NR Program's annual report ''The United States Naval Nuclear Propulsion Program'' (referred to as the Grey Book). The attachment to this letter provides a draft of the Prometheus Program report for NR review and approval. As stated in the Reference, a March 2005 issuance is planned following a coordinated NR Headquarter's review. The information contained in the attached report was obtained from open literature sources, NASA documents and Naval Reactors Program literature. The photographs contained in the report are drafts and their quality will be improved in the final version of the report. This report has been reviewed by the KAPL and Bettis Space Power Plant Staff and has been concurred with by the Manager of Space Power Plant (MJ Wollman) and the Manager of Bettis Reactor Engineering (C Eshelman)

  15. Guidance for package approvals in the United Kingdom

    International Nuclear Information System (INIS)

    Morgan-Warren, E.J.

    2004-01-01

    Approval is required under the transport regulations for a wide range of package designs and operations, and applications for competent authority approval and validation are received from many sources, both in the UK and overseas. To assist package designers and applicants for approval, and to promote consistency in applications and their assessment, the UK Department for Transport issues guidance on the interpretation of the transport regulations and the requirements of an application for approval and its supporting safety case. The general guidance document, known as the Guide to an Application for UK Competent Authority Approval of Radioactive Material in Transport, has been issued for many years and updated to encompass the provisions of each successive edition of the IAEA transport regulations. The guide has been referred to in a number of international fora, including PATRAM, and was cited as a 'good practice' in the report of the IAEA TRANSAS appraisal of the UK in 2002. Specialist guides include the Guide to the Suitability of Elastomeric Seal Materials, which is the subject of a separate paper in this conference, and the Guide to the Approval of Freight Containers as Types IP-2 and IP-3 Packages. This paper discusses the guidance material and summarises the administrative and technical information required in support of applications for approval of package designs, special form and low-dispersible radioactive materials, shipments, special arrangements, modifications and validations. (author)

  16. Effect of Need for Approval and Situational Variables on the Viewing of Erotic Material

    Science.gov (United States)

    Kirschner, Neil M.

    1976-01-01

    The role of social desirability on willingness to view erotic materials under conditions of implicit approval and disapproval was studied. Low need-for-approval subjects were more influenced by situational cues than high need-for-approval subjects. (NG)

  17. New Breast Cancer Treatment Approved | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... Breast Cancer Treatment Approved Follow us New Breast Cancer Treatment Approved Photo: Wikimedia Commons IN THE NEWS - Breast ... Food and Drug Administration approved a new breast cancer treatment that aims to reduce the risk of the ...

  18. Project W-314 phase I environmental permits and approvals plan

    International Nuclear Information System (INIS)

    TOLLEFSON, K.S.

    1999-01-01

    This document describes the range of environmental actions, including required permits and other agency approvals, for Project W-314 activities in the Hanford Site's Tank Waste Remediation System. This document outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for waste feed delivery to proceed. This document also includes estimated costs and schedule to obtain the required permits and approvals based on the selected strategy. It also provides estimated costs for environmental support during design and construction based on the preliminary project schedule provided

  19. HSE statement on the approval of dosimetry services

    International Nuclear Information System (INIS)

    1992-09-01

    This statement is intended to assist dosimetry services who may wish to be approved by the U.K. Health and Safety Executive under Regulation 15 of the Ionising Radiations Regulations 1985. It also serves to inform approved dosimetry services of changes in the arrangements which HSE makes for approval and reassessment of dosimetry services. A general description of the administrative arrangements for making application is given and the subsequent processing of such applications by the HSE is outlined. Background notes on the requirements of the Regulations are given in Appendix I. The fees which are chargeable from 20/8/92 are given in Appendix II. (Author)

  20. Grandfathering of competent authority approved packages

    International Nuclear Information System (INIS)

    Osgood, N.L.

    2004-01-01

    International Atomic Energy Agency transportation regulations are reviewed and revised on a periodic basis as new technical and scientific information becomes available. The 1996 Edition of the Regulations for the Safe Transport of Radioactive Materials in TS-R-1 includes provisions for the use of package designs approved to previous editions of the regulations. This assures that there is no disruption of transport when the regulations are updated and revised. The revision of package design standards may make certain designs obsolete, though not necessarily unsafe. The U.S. Nuclear Regulatory Commission is the agency in the United States that certifies transportation packages for Type B and fissile materials. NRC regulations include grandfathering provisions that are comparable to and compatible with the IAEA standards. NRC staff is promoting a new system that would eliminate the need to grandfather package designs. Under the new method, any new or revised provision of the regulations that affects package standards would include its own transitional arrangements. In this way, each change would be evaluated for its safety importance. Changes in the package standards that are important to safety would be implemented immediately upon the regulations coming into force. Other changes, that do not significantly affect safety, would have longer implementation periods. In this way, all packages in use would be compatible with the regulations in force, and no specific grandfathering provisions for older designs would be needed. NRC staff has concluded that the package design standards are mature and have been shown to be protective over the past 40 years of shipping experience. We predict that future changes in package design standards will not be substantive in terms of resulting in significant changes in physical performance of a package in transport, including actual transportation accidents. The benefits of the new system would be a more predictable regulatory structure

  1. 75 FR 57019 - Pesticide Product Registrations; Conditional Approval

    Science.gov (United States)

    2010-09-17

    ..., the Agency was able to make basic health and safety determinations which show that use of flutriafol... unreasonable adverse effects to man and the environment. III. Conditional Approval Form EPA issued a notice...

  2. 22 CFR 129.6 - Requirement for license/approval.

    Science.gov (United States)

    2010-04-01

    ... LICENSING OF BROKERS § 129.6 Requirement for license/approval. (a) No person may engage in the business of... member country of that Organization, Australia, Japan, New Zealand, or South Korea, except in the case of...

  3. 40 CFR 85.1804 - Approval of Plan: Implementation.

    Science.gov (United States)

    2010-07-01

    ... nonconformity, he will so notify the manufacturer in writing. If the remedial plan is not approved, the... nonconformity, the Administrator shall, within 60 days after the completion of such hearing, order the manufacturer to provide prompt notification of such nonconformity. ...

  4. Cognitive Properties of Approval Voting : an Experimental Approach

    Directory of Open Access Journals (Sweden)

    Krzysztof Przybyszewski

    2011-01-01

    Full Text Available The paper summarizes two series of experiments demonstrating the cognitive properties of approval voting. The former series is devoted to mental processes induced in decision makers who use the method of approval voting. Based on cognitive effort, the use of choice strategies is presented in this paper. The observations of respondents show that most of them use relatively effortless strategy of eliminating alternatives and attributes. Few respondents use more sophisticated methods. The other series of experiments analyses the number of alternatives chosen in approval voting. It appears that the average number is not constant, even for similar votes but it depends on the subject of voting. The number of chosen alternatives and the subjective significance of the scope of voting are negatively or positively correlated in the case of special votes. The analyzed experiments show that the cognitive properties of approval voting have a diverse structure. (original abstract

  5. 44 CFR 78.10 - Project grant approval process.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION ASSISTANCE § 78.10 Project grant approval process. The State POC will solicit applications from...

  6. A guide for approval of nuclear gauging devices

    International Nuclear Information System (INIS)

    1990-01-01

    This guide has been written to assist manufacturers, distributors and users of nuclear gauging devices in the preparation of a submission to the Atomic Energy Control Board in support of a request for approval of a nuclear gauging device

  7. Uganda cabinet approves policy initiated by IDRC grantee | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-28

    Jun 28, 2016 ... The Economic Policy Research Centre (EPRC), an IDRC grantee under the ... on May 4, 2016, with cabinet approval of their National Fertilizer Policy. ... that 20% of the country's population has some form of physical disability.

  8. 27 CFR 4.40 - Label approval and release.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements for Withdrawal of Wine From..., denial, and revocation of certificates of label approval, as well as appeal procedures, see part 13 of...

  9. 27 CFR 7.31 - Label approval and release.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF MALT BEVERAGES Requirements for Withdrawal of... approval, as well as appeal procedures, see part 13 of this chapter. [T.D. ATF-66, 45 FR 40552, June 13...

  10. 27 CFR 7.41 - Certificates of label approval.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF MALT BEVERAGES Requirements for Approval of..., as well as appeal procedures, see part 13 of this chapter. [T.D. ATF-406, 64 FR 2129, Jan. 13, 1999...

  11. 27 CFR 5.51 - Label approval and release.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Requirements for Withdrawal..., and revocation of certificates of label approval, as well as appeal procedures, see part 13 of this...

  12. Clean Water Act Approved Total Maximum Daily Load (TMDL) Documents

    Data.gov (United States)

    U.S. Environmental Protection Agency — Information from Approved and Established TMDL Documents as well as TMDLs that have been Withdrawn. This includes the pollutants identified in the TMDL Document, the...

  13. 12 CFR 918.5 - Approval by Finance Board.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Approval by Finance Board. 918.5 Section 918.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD GOVERNANCE AND MANAGEMENT OF THE FEDERAL HOME LOAN BANKS BANK DIRECTOR COMPENSATION AND EXPENSES § 918.5 Approval by Finance Board. Payments made to directors in compliance with the limits on annual...

  14. Fratura periprotética da tíbia combinada com fratura de fadiga da haste tibial de artroplastia total do joelho Tibial periprosthetic fracture combined with tibial stem stress fracture from total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    Fernando Fonseca

    2011-01-01

    Full Text Available As complicações das artroplastias totais do joelho relacionadas com o próprio material são muito raras, exceto o desgaste do polietileno. Neste artigo os autores reportam o caso de uma paciente do sexo feminino de 58 anos referenciada ao pronto-socorro do nosso hospital por uma fratura periprotética tibial (tipo I da classificação da Mayo Clinic. Uma observação mais cuidadosa mostrou a presença concomitante da referida fratura da tíbia associada à fratura de fadiga da haste tibial. A prótese com a haste foi remetida a um laboratório de biomecânica independente onde foi avaliada e efetuada uma reconstrução com uso de sistema de elementos finitos em CAD de modo a verificar a existência de algum defeito de fabricação e as eventuais causas para o sucedido. Depois de avaliadas diversas hipóteses, concluiu-se que a fratura do material foi provocada por uma sobrecarga na zona de transição prato/haste secundária à falência óssea prévia (fratura. Da avaliação do caso ressalta-se novamente a necessidade de efetuar uma avaliação adequada da mineralização óssea e, em caso de dúvida, utilizar uma haste longa.Total knee arthroplasty complications related to the prosthetic material are very rare, except for polyethylene wear. We report the case of a 58-year-old woman who came to the emergency service of our hospital with a periprosthetic tibial fracture (Mayo Clinic type I. Careful examination showed that this fracture was concomitantly associated with a tibial stem fatigue fracture. The prosthesis and the stem were sent to an independent biomechanics laboratory for evaluation. A finite-element CAD system was used to make a reconstruction, so as to ascertain whether there had been any manufacturing defect and what the causes of the event might have been. After evaluation of several hypotheses, it was concluded that the fracture in the prosthetic material had been caused by overloading at the plate/stem transition zone

  15. O papel do esteroide anabolizante sobre a hipertrofia e força muscular em treinamentos de resistência aeróbia e de força

    Directory of Open Access Journals (Sweden)

    Everton Crivoi do Carmo

    2011-06-01

    Full Text Available INTRODUÇÃO: Os efeitos dos esteroides anabolizantes (EA sobre a massa muscular e força são controversos e dependentes do treinamento realizado e das fibras musculares recrutadas. Com isso, o objetivo deste estudo foi avaliar os efeitos da associação de EA ao treinamento de força ou aeróbio sobre a hipertrofia e força muscular. MÉTODOS: Ratos Wistar (42 foram divididos em seis grupos: sedentário (SC, n = 7, sedentário anabolizante (SA, n = 7, treinado natação controle (TNC, n = 7, treinado natação anabolizante (TNA, n = 7, treinado força controle (TFC, n = 7 e treinado força anabolizante (TFA, n = 7. O EA foi administrado duas vezes por semana (10mg/kg/semana. Os protocolos de treinamento foram realizados durante 10 semanas, cinco sessões semanais. Foram avaliadas a hipertrofia dos músculos sóleo, plantar e gastrocnêmio (massa muscular corrigida pelo comprimento da tíbia, a proteína total muscular (Bradford e a força muscular em patas traseiras (testes de resistência à inclinação. RESULTADOS: Não foram observadas diferenças significantes na hipertrofia do músculo sóleo. Os grupos TFC e TFA apresentaram, respectivamente, hipertrofia de 18% e 31% no músculo plantar comparado ao grupo SC. A hipertrofia foi 13% maior no grupo TFA em relação ao grupo TFC. Resultados semelhantes foram encontrados no músculo gastrocnêmio. Os grupos TFC e TFA apresentaram significantes aumentos na quantidade total de proteína nos músculos plantares, sendo essa mais pronunciada no grupo TFA e positivamente correlaciona a hipertrofia muscular. Observamos aumento de força nas patas traseiras nos grupos TCF e TAF. CONCLUSÃO: A administração de EA ou sua associação ao treinamento aeróbio não aumenta a massa muscular e força. Porém, à associação ao treinamento de força leva a maior hipertrofia muscular em fibras glicolíticas. Portanto, o tipo de treinamento físico, recrutamento muscular e características das fibras

  16. 77 FR 49003 - Notice of Proposed Information Collection for Public Comment: Request for Acceptance of Changes...

    Science.gov (United States)

    2012-08-15

    ... the information collection. The lender reviews the changes and amends the approved exhibits. These... a mortgage on property that poses a risk to health or safety of the occupant. DATES: Comments Due... the information collection. The lender reviews the changes and amends the approved exhibits. These...

  17. 77 FR 47861 - Notice of Submission of Proposed Information Collection to OMB Hispanic-Serving Institutions...

    Science.gov (United States)

    2012-08-10

    .... The lender reviews the changes and amends the approved exhibits. These changes ma affect the value... that poses a risk to health or safety of the occupant. DATES: Comments Due Date: September 10, 2012.... The lender reviews the changes and amends the approved exhibits. These changes ma affect the value...

  18. 75 FR 15645 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Revisions to the Emission...

    Science.gov (United States)

    2010-03-30

    ... clarify EPA's role in the approval of emission quantification protocols. While the previous SIP- approved... approve severable portions of two revisions to the Texas State Implementation Plan (SIP) submitted by the... to further clarify procedures for using emission protocols and to update the approved list of...

  19. 30 CFR 285.614 - When may I begin conducting activities under my approved SAP?

    Science.gov (United States)

    2010-07-01

    ... approved SAP? 285.614 Section 285.614 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Plans and Information Requirements Activities Under An Approved Sap § 285.614 When may I begin conducting activities under my approved SAP? (a) You may begin conducting the activities approved in your SAP...

  20. Miracle drug: Brazil approves never-tested cancer medicine.

    Science.gov (United States)

    Kuchenbecker, Ricardo S; Mota, Daniel M

    2017-07-01

    Background Brazil recently approved synthetic phosphoetanolamine, a popularly dubbed 'cancer pill', a substance that has been shown to kill cancer cells in lab animal models but was not yet formally accessed in humans, and thus despite the existence of any evidence of its efficacy and safety. Methods The authors describe the recent decision of Brazil to aprove phosphoetanolamine in the context of growing 'judicialization' to promote access to medicines and thus reinforcing a growing sense of legal uncertainty. Results The approval of phosphoetanolamine despite the existence of any evidence of its efficacy and safety represents to the authors one of the saddest and surrealistic episodes in Brazil's recent public health history. Brazil's current economic crisis is fueling the 'judicialization' to promote access to medicines and thus reinforcing a growing sense of legal uncertainty in the context of rising economic constrains and a progressive failing state. The authors state that the Phosphoetanolamine's approval bill violates current legal prohibition of commercialisation of drugs without the Brazilian national drug regulatory agency's approval and thus may represent a potential menace to Brazil's pharmacogovernance and the country's governance to health technology assessment at the Brazilian national health systems. Conclusion Phosphoetanolamine's approval illustrates that the combination of flawed decision making, economic crisis and political interference may threaten weak governance mechanisms for drug regulation and health technology assessment and thus representing an extra burden in the sustainability of universal access-based national health systems.

  1. A drug's life: the pathway to drug approval.

    Science.gov (United States)

    Keng, Michael K; Wenzell, Candice M; Sekeres, Mikkael A

    2013-10-01

    In the United States, drugs and medical devices are regulated by the US Food and Drug Administration (FDA). A drug must undergo rigorous testing prior to marketing to and medical use by the general public. The FDA grants marketing approval for drug products based on a comprehensive review of safety and efficacy data. This review article explains the history behind the establishment of the FDA and examines the historical legislation and approval processes for drugs, specifically in the fields of medical oncology and hematology. The agents imatinib (Gleevec, Novartis) and decitabine (Dacogen, Eisai) are used to illustrate both the current FDA regulatory process-specifically the orphan drug designation and accelerated approval process-and why decitabine failed to gain an indication for acute myeloid leukemia. The purpose and construct of the Oncologic Drugs Advisory Committee are also discussed, along with examples of 2 renal cell cancer drugs-axitinib (Inlyta, Pfizer) and tivozanib-that used progression-free survival as an endpoint. Regulatory approval of oncology drugs is the cornerstone of the development of new treatment agents and modalities, which lead to improvements in the standard of cancer care. The future landscape of drug development and regulatory approval will be influenced by the new breakthrough therapy designation, and choice of drug will be guided by genomic insights.

  2. REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

    International Nuclear Information System (INIS)

    Markman, D.W.

    1999-01-01

    Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

  3. Reporting ethics committee approval in public administration research.

    Science.gov (United States)

    Jordan, Sara R; Gray, Phillip W

    2014-03-01

    While public administration research is thriving because of increased attention to social scientific rigor, lingering problems of methods and ethics remain. This article investigates the reporting of ethics approval within public administration publications. Beginning with an overview of ethics requirements regarding research with human participants, I turn to an examination of human participants protections for public administration research. Next, I present the findings of my analysis of articles published in the top five public administration journals over the period from 2000 to 2012, noting the incidences of ethics approval reporting as well as funding reporting. In explicating the importance of ethics reporting for public administration research, as it relates to replication, reputation, and vulnerable populations, I conclude with recommendations for increasing ethics approval reporting in public administration research.

  4. EPA Facility Registry Service (FRS): BIA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  5. Tratamento da pseudartrose infectada da tíbia pelo método de Ilizarov: técnica do encurtamento agudo com subseqüente alongamento Treatment of infected pseudoarthrosis of the tibia by Ilizarov's method: technique using acute compression and subsequent distraction

    Directory of Open Access Journals (Sweden)

    Jorge Luiz Borges

    2007-09-01

    Full Text Available OBJETIVO:Comprovar a eficácia do tratamento da pseudartrose infectada da tíbia pelo método de Ilizarov, utilizando a técnica do encurtamento agudo do foco da pseudartrose com posterior alongamento ósseo. MÉTODOS: Foram estudados 20 pacientes adultos portadores de pseudartrose unilateral infectada da tíbia, tratados no período entre novembro de 1993 e setembro de 2000. No pós-operatório, os pacientes foram avaliados quanto a dor, necessidade de órtese, avaliação da mobilidade articular, retorno às atividades normais do dia-a-dia e/ou do trabalho, consolidação da pseudartrose, cura da infecção, existência de deformidades ósseas, discrepância no comprimento dos membros e consolidação óssea na área do regenerado ósseo. RESULTADOS: Os resultados funcionais foram: excelentes em 10 pacientes (50%, bons em oito (40%, regulares em um (5% e ruins em um paciente (5%. O tempo de consolidação da pseudartrose, do segmento ósseo alongado e o tempo de uso do fixador foram proporcionais à extensão da perda óssea. CONCLUSÃO: O método de Ilizarov, associado ao encurtamento agudo com subseqüente alongamento ósseo, mostrou-se eficaz para o tratamento da pseudartrose infectada da tíbia.OBJECTIVE: To verify the effectiveness of treating the infected pseudoarthrosis of the tibia by Ilizarov's method using the technique of acute compression of the focus of pseudoarthrosis with later bone distraction. METHODS: 20 adult patients with unilateral infected pseudoarthrosis of the tibia treated from November 1993 to September 2000 were studied. In the postoperative period, the patients were evaluated for pain, orthesis requirement, joint mobility, return to daily life activities and/or to work, union of the pseudoarthrosis, cure of the infection, presence of bone deformities, discrepancy in limb length, and bone union in the bone regenerate area. RESULTS: Functional results were: excellent in 10 patients (50%, good in eight (40%, regular in

  6. 24 CFR 241.500 - Definitions.

    Science.gov (United States)

    2010-04-01

    ....102. (b) Borrower means the owner of a project held in fee simple or of a leasehold interest which is... indicated: (a) Approved lender means a financial institution or other mortgagee approved by the Commissioner...

  7. 7 CFR 1980.454 - Conditions precedent to issuance of the Loan Note Guarantee.

    Science.gov (United States)

    2010-01-01

    ... percent in loan amounts between $1 million and $10 million. 4. Basic credit requirements of all loans. B... experience of the new lender before the request is approved. If approved, notify the Finance Office of the...

  8. Problems of the current law concerning official plan approval

    International Nuclear Information System (INIS)

    Bluemel, W.

    1986-01-01

    The booklet presents lectures held in October 1985 at the Speyer University for Administration Science, on the subject of the law concerning official plan approval. The lectures have been selected for their common interest in the requirements of nature conservation and landscape protection. These requirements and the current practice of plan approval procedure are the main issue of the lectures which discuss aspects of environmental impact statements, consideration of ecological requirements, and the role of the landscape conservation plan accompanying official project planning documents. (HSCH) [de

  9. Defending submission-year analyses of new drug approvals.

    Science.gov (United States)

    Carpenter, Daniel P

    2003-01-01

    In response to the critique of Mary Olsen, Daniel Carpenter, on behalf of his co-authors, addresses the issue of analysis based on the year a new drug is submitted for Food and Drug Administration (FDA) approval, not the year it is approved. Both substantive knowledge of the FDA drug review process and sound social science theory favor submission-year averaging. The history and bureaucratic mechanics of the Center for Drug Evaluation and Review (CDER) conform to the author's assumption. The statistical theory of optimal experimentation also points to the beginning of review as a locus for effects upon decisions.

  10. New technology planning and approval: critical factors for success.

    Science.gov (United States)

    Haselkorn, Ateret; Rosenstein, Alan H; Rao, Anil K; Van Zuiden, Michele; Coye, Molly J

    2007-01-01

    The steady evolution of technology, with the associated increased costs, is a major factor affecting health care delivery. In the face of limited capital resources, it is important for hospitals to integrate technology management with the strategic plan, mission, and resource availability of the organization. Experiences in technology management have shown that having a well-organized, consistent approach to technology planning, assessment, committee membership, approval, evaluation, implementation, and monitoring are key factors necessary to ensure a successful program. We examined the results of a survey that assessed the structure, processes, and cultural support behind hospital committees for new technology planning and approval.

  11. Stakeholder cooperation: regulating a uranium mine with multiple statutory approvals

    International Nuclear Information System (INIS)

    Bush, M.

    2010-01-01

    Ranger Uranium Mine operates under an Authorisation issued by the Northern Territory Government. In addition, the site is regulated by a set of Environmental Requirements attached to the uranium export permit issued by the Australian Government Department of Resources, Energy and Tourism. A Heap Leach facility proposed for the site could result in a third approval being issued, in accordance with the Environmental Protection and Biodiversity Conservation Act 1999 (EPBC Act). Finding the correct balance to regulate the mine in light of these approvals will be a challenge for the range of stakeholders involved in regulation and oversight of this operation. (author)

  12. Number of patients studied prior to approval of new medicines

    DEFF Research Database (Denmark)

    Duijnhoven, Ruben G; Straus, Sabine M J M; Raine, June M

    2013-01-01

    length of time), whereas 67 (79.8%) of the medicines met the criteria for 12-mo patient exposure (at least 100 participants studied for 12 mo). CONCLUSIONS: For medicines intended for chronic use, the number of patients studied before marketing is insufficient to evaluate safety and long-term efficacy....... Both safety and efficacy require continued study after approval. New epidemiologic tools and legislative actions necessitate a review of the requirements for the number of patients studied prior to approval, particularly for chronic use, and adequate use of post-marketing studies. Please see later...

  13. Inventory information approval system certification and flexible spending account purchases.

    Science.gov (United States)

    Shuey, Brandon; Williams, La Vonn A

    2010-01-01

    There is no question that 2009 was a year of change within the pharmacy industry. Several new requirements were implemented, including the need for an Inventory Information Approval System for accepting flexible spending or health reimbursement account cords. Some pharmacies relied on the 90% exemption rule, which is discussed within this article, or an alternative method to avoid the expense of a point of sale. However, with flexible spending or health reimbursement account card participation expected to reach 85% in 2010, now bay be the time for compounding pharmacists to weigh the pros and cons of Inventory Information Approval System certification.

  14. 38 CFR 36.4340 - Underwriting standards, processing procedures, lender responsibility, and lender certification.

    Science.gov (United States)

    2010-07-01

    ... association fees, etc., and any long-term obligations divided by the total of gross salary or earnings and... military duty require special attention. The retirement income of the latter veterans in many cases may not... other collection activities. The amount of rental income to be used in the loan analysis will be based...

  15. Biodigestão anaeróbia de dejetos de caprinos obtidos nas diferentes estações do ano Anaerobic digestion of caprine manure in different seasons

    Directory of Open Access Journals (Sweden)

    Ana C. Amorim

    2004-04-01

    Full Text Available Foram utilizados dejetos produzidos por caprinos, em diferentes estádios fisiológicos e submetidos ao mesmo regime alimentar, nas quatro estações do ano. O objetivo foi avaliar o efeito das estações do ano sobre a digestão anaeróbia de resíduos de caprinos em biodigestores modelo batelada com volume útil de 60 L de substrato em fermentação e mantidos sob temperatura ambiente. Foram avaliadas as produções de biogás, as reduções de sólidos voláteis (SV, os potenciais de produção (m³ de biogás/kg de substrato, de estrume, de sólidos totais (ST ou sólidos voláteis, os números mais prováveis de coliformes totais e fecais, e a composição do biogás. As reduções de SV foram de 38; 34; 33 e 39% para o verão, outono, inverno e primavera, respectivamente. Os totais de biogás produzidos foram de 1,06 m³ no verão, 0,88 m³ no outono, 0,88 m³ no inverno e 0,99 m³ na primavera, e os potenciais de produção médios foram de 0,02 m³ de biogás/kg de substrato e 0,2 m³ de biogás/kg de estrume para todas as estações. As reduções médias de coliformes totais e fecais foram de 99,99% em todas as estações, e os teores máximos de CH4 no biogás foram 88,3; 84,6; 80,6 e 79,2%, para o verão, outono, inverno e primavera, respectivamente.The dejections produced by caprines were used, in different physiologic states and submitted to the same alimentary regime, in the four seasons of the year.This study was carried out in 60 L batch digesters at ambient temperature and aimed to evaluate the effect of the season on the anaerobic digestion of caprine manure. The biogas production, volatile solids (VS reduction, the potential production (m³ of biogas/kg of substrate, manure, total solids (TS or VS, the removal of total and fecal coliforms and the biogas composition were evaluated. The VS reductions were of 38; 34; 33 and 39% for Summer, Autumn, Winter and Spring, respectively. The biogas production were of 1.06 m³ in Summer

  16. Biodigestão anaeróbia de dejetos de poedeiras coletados após diferentes períodos de acúmulo Anaerobic biodigestion of laying hens manure collected after different periods of accumulation

    Directory of Open Access Journals (Sweden)

    Romildo Marques de Farias

    2012-06-01

    Full Text Available O objetivo do trabalho foi avaliar a interferência do tempo de acúmulo sobre o desempenho do processo de biodigestão anaeróbia de dejetos de aves de postura. O experimento foi conduzido em delineamento inteiramente casualizado com quatro tratamentos que constaram de 1, 8, 15 e 22 dias de acúmulo dos dejetos, efetuando-se cinco repetições por tratamento, totalizando assim 20 biodigestores. Foram utilizados biodigestores do tipo batelada de bancada com capacidade útil para 3 litros de substrato em fermentação. A eficiência do processo de biodigestão foi avaliada pelas reduções de sólidos totais (ST, sólidos voláteis (SV, número mais provável (NMP de coliformes totais e termotolerantes, além das produções e dos potenciais de produção de biogás. Foram observadas reduções significativas dos conteúdos de SV presentes nos dejetos de aves à medida que se aumentaram os dias de acúmulo, sendo observados teores de SV (em % dos ST de 97,1 e 75,6% no primeiro e após 22 dias de acúmulo, respectivamente. A redução de SV contribuiu para reduzir a produção e os potenciais de produção do biogás à medida que se aumentaram os dias de acúmulo, sendo observada redução de 37,2% no potencial de produção de biogás kg de SV-1 entre o menor e maior período de acúmulo, ou seja, 6,81 litros de biogás a menos por dia de acúmulo para cada kg de SV adicionado. Também foram observadas reduções de 100% no NMP de coliformes totais e termotolerantes ao final do processo, independente do tratamento testado. O tempo de estocagem contribui para reduzir os potenciais de produção de biogás dos dejetos de aves de postura.The objective was to evaluate the interference of the time of accumulation of waste on the performance of the anaerobic digestion process of waste from laying hens. The experiment was conducted in a completely randomized design with four treatments, which observed 1, 8, 15 and 22 days of accumulated waste with five

  17. Anaerobic digestion of vinasse: energetic application of biogas and acquisition of credits of carbon – a case Biodigestão anaeróbia da vinhaça: aproveitamento energético do biogás e obtenção de créditos de carbono – estudo de caso

    Directory of Open Access Journals (Sweden)

    Rafaelo Balbinot

    2010-12-01

    Full Text Available The increase of the ethanol production in Brazil leads to growing of vinasse (main by-product of sugar and alcohol industry, worsing the problem related to its destinantion. Vinasse is rich in nutrients and has a high content of organic matter, which justifies its intense ferti-irrigation use in sugar cane crop areas. Thus, the anaerobic digestion of vinasse by UASB (upflow anaerobic sludge blanket digestion reactor emerges as an alternative treatment for this by-product, showing also an economic factor, the production of methane and its use. This work aimed to implement the system of anaerobic digestion of vinasse in UASB reactor and the use of energy generated by biogas. In this way, the design of UASB was based on organic volumetrical load of vinasse. The estimation of the baseline was based on the mass balance between the carbon present in the vinasse and CO2 emitted by the aerobic degradation of effluent into the environment. From the compute emissions, it was found that emissions from the baseline and the project implementation would be the same, and additionally it could be occur the production of electricity by biogas. In this way, biogas produced by anaerobic digestion has a competitive energy potential compared to other energy sources and presents additionality; however, carbon credits marked could not be a financial attractive in the development of this type of project.A crescente produção de etanol no Brasil acarretou aumento na produção de vinhaça (principal subproduto da indústria sucroalcoleira, agravando o problema de sua destinação. A vinhaça é rica em nutrientes minerais e apresenta elevado teor de matéria orgânica, o que justifica sua intensa utilização na fertirrigação de áreas cultivadas com cana. Neste cenário, a biodigestão anaeróbia da vinhaça em reatores UASB (upflow anaerobic sludge blanket digestion surge como uma alternativa de tratamento deste subproduto apresentando, ainda, um fator econ

  18. Relação da aptidão aeróbia e muscular com a composição corporal, o estado maturacional e a actividade física habitual de crianças e adolescentes (9-11 anos)

    OpenAIRE

    João, Félix Rodrigues

    2008-01-01

    Dissertação de Mestrado em Avaliação nas Actividades Físicas e Desportivas O objectivo deste estudo foi examinar em raparigas e rapazes, com idades compreendidas entre os 9 e os 11 anos de idade, a relação da aptidão aeróbia (ApA) e muscular (ApM) com a composição corporal (MG, massa gorda; MIG, massa isenta de gordura; PCI, perímetro da cintura 1), o índice de actividade física (AFH) e o estado maturacional (EM). Foi também nosso propósito identificar o desempenho dos referidos testes ent...

  19. 7 CFR 996.22 - USDA-approved laboratory.

    Science.gov (United States)

    2010-01-01

    ..., Agricultural Marketing Service, USDA, that chemically analyze peanuts for aflatoxin content. Quality and... 7 Agriculture 8 2010-01-01 2010-01-01 false USDA-approved laboratory. 996.22 Section 996.22 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

  20. 18 CFR 1304.4 - Application review and approval process.

    Science.gov (United States)

    2010-04-01

    ... hearing is requested by the USACE pursuant to the TVA/Corps joint processing Memorandum of Understanding... the application as appropriate. (b) If a hearing is held for any of the reasons described in paragraph... contained in the hearing notice. (c) Hearings concerning approval of applications are conducted (in...

  1. Developing, Approving and Maintaining Qualifications: Selected International Approaches. Research Report

    Science.gov (United States)

    Misko, Josie

    2015-01-01

    There are lessons for Australia in the key approaches to the development, approval, maintenance and quality assurance of qualifications adopted in countries overseas. This research takes into account a range of approaches used in selected European Union (EU) member states (Germany, Finland and Sweden), the United Kingdom (England, Northern Ireland…

  2. Bacteria-eating virus approved as food additive.

    Science.gov (United States)

    Bren, Linda

    2007-01-01

    Not all viruses harm people. The Food and Drug Administration has approved a mixture of viruses as a food additive to protect people. The additive can be used in processing plants for spraying onto ready-to-eat meat and poultry products to protect consumers from the potentially life-threatening bacterium Listeria monocytogenes (L. monocytogenes).

  3. Aviation Maintenance Technology. Course Content Guides. FAA Approved Curriculum.

    Science.gov (United States)

    Shrawder, Jack; And Others

    Course content guides are provided for the 30 courses in this aviation maintenance technology curriculum approved by the Federal Aviation Administration. Course titles are physics for technicians; aircraft information, regulations, and procedures; aircraft assembly; fundamentals of aircraft electronics; aircraft electrical components; aircraft…

  4. 29 CFR 1956.24 - Procedures for withdrawal of approval.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Procedures for withdrawal of approval. 1956.24 Section 1956.24 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... do so, at least developmentally), no industrial or occupational issues may be considered a separable...

  5. 48 CFR 970.5236-1 - Government facility subcontract approval.

    Science.gov (United States)

    2010-10-01

    ... Approval (DEC 2000) Upon request of the Contracting Officer and acceptance thereof by the Contractor, the... and wages required by law to be included in contracts for the construction, alteration, and/or repair... ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Solicitation Provisions...

  6. FDA-approved small-molecule kinase inhibitors

    DEFF Research Database (Denmark)

    Wu, Peng; Nielsen, Thomas E.; Clausen, Mads Hartvig

    2015-01-01

    Kinases have emerged as one of the most intensivelypursued targets in current pharmacological research,especially for cancer, due to their critical roles in cellularsignaling. To date, the US FDA has approved 28 smallmoleculekinase inhibitors, half of which were approvedin the past 3 years. While...

  7. 5 CFR 6401.103 - Prior approval for outside employment.

    Science.gov (United States)

    2010-01-01

    .... 6401.103 Section 6401.103 Administrative Personnel ENVIRONMENTAL PROTECTION AGENCY SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE ENVIRONMENTAL PROTECTION AGENCY § 6401.103 Prior approval... her Deputy Ethics Official before engaging in outside employment, with or without compensation, that...

  8. The Cost of Delaying Approval of Golden Rice

    NARCIS (Netherlands)

    Wesseler, J.H.H.; Kaplan, S.; Zilberman, D.

    2014-01-01

    More than 250,000 children go blind every year because of Vitamin A deficiency. Vitamin A intake can be enhanced by consuming Golden Rice—a genetically engineered variety of rice. It was available for commercialization in 2002, but approval has been delayed. We estimate that this delay has resulted

  9. Olaparib Approved for Breast Cancers with BRCA Gene Mutations

    Science.gov (United States)

    The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as well as a companion diagnostic test for selecting candidates for the therapy.

  10. Forecasting Housing Approvals in Australia: Do Forecasters Herd?

    DEFF Research Database (Denmark)

    Stadtmann, Georg; Pierdzioch; Rülke

    2012-01-01

    Price trends in housing markets may reflect herding of market participants. A natural question is whether such herding, to the extent that it occurred, reflects herding in forecasts of professional forecasters. Using more than 6,000 forecasts of housing approvals for Australia, we did not find...

  11. Approval Motive and Academic Behaviors: The Self Reinforcement Hypothesis

    Science.gov (United States)

    Matell, Michael S.; Smith, Ronald E.

    1970-01-01

    Testing of college students in differing conditions as to performance being relevant to academic achievement goals revealed that under hgih relevance conditions scores on the Marlowe Crowne Social Desirability Scale were unrelated to test performance. Under low relevant conditions, the need for approval was highly related to performance in high…

  12. Drugs Approved for Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for ovarian cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  13. 46 CFR 160.077-6 - Approval procedures.

    Science.gov (United States)

    2010-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... to the particular design or that by design or construction the PFD cannot fail the test. (c) Alternative Requirements. A PFD that does not meet requirements in this subpart may still be approved if the...

  14. 46 CFR 163.002-9 - Approval procedure.

    Science.gov (United States)

    2010-10-01

    ... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... designs. A pilot hoist that does not meet the materials, construction, or performance requirements of this... or in addition to the approval tests required by this subpart, show that the alternative materials...

  15. 77 FR 30327 - Approval of Information Collection Requirements; Comment Request

    Science.gov (United States)

    2012-05-22

    ... affirmative action programs based on functional or business units. A copy of this information collection... the request for Office of Management and Budget approval of the information collection request. FOR... regardless of race, sex, color, national origin, religion, or status as a qualified individual with a...

  16. Alcohol addiction - the safety of available approved treatment options.

    Science.gov (United States)

    Antonelli, Mariangela; Ferrulli, Anna; Sestito, Luisa; Vassallo, Gabriele A; Tarli, Claudia; Mosoni, Carolina; Rando, Maria M; Mirijello, Antonio; Gasbarrini, Antonio; Addolorato, Giovanni

    2018-02-01

    Alcohol Use Disorders (AUD) is a leading cause of mortality and morbidity worldwide. At present disulfiram, naltrexone and acamprosate are approved for the treatment of AUD in U.S. and Europe. Nalmefene is approved in Europe and sodium oxybate is approved in Italy and Austria only. Baclofen received a 'temporary recommendation for use' in France. Areas covered: The safety of the above mentioned medications on liver, digestive system, kidney function, nervous system, pregnancy and lactation and their possible side effects are described and discussed. Expert opinion: Mechanism of action and metabolism of these drugs as well as patients' clinical characteristics can affect the safety of treatment. All approved medications are valid tools for the treatment of AUD in patients without advanced liver disease. For some drugs, attention should be paid to patients with renal failure and medications may be used with caution, adjusting the dosage according to kidney function. In patients with AUD and advanced liver disease, at present only baclofen has been formally tested in randomized controlled trials showing its safety in this population.

  17. Pharmacovigilance of biologicals : dynamics in post-approval safety learning

    NARCIS (Netherlands)

    Vermeer, N.S.

    2015-01-01

    Regulatory decisions to allow new drugs on the market by definition have to accept a certain level of uncertainty about the full benefit-risk balance. Pre-approval studies typically provide information on a limited number of patients over a relative short follow-up period, and handle strict

  18. Timelines of translational science: From technology initiation to FDA approval.

    Directory of Open Access Journals (Sweden)

    Laura M McNamee

    Full Text Available While timelines for clinical development have been extensively studied, there is little data on the broader path from initiation of research on novel drug targets, to approval of drugs based on this research. We examined timelines of translational science for 138 drugs and biologicals approved by the FDA from 2010-2014 using an analytical model of technology maturation. Research on targets for 102 products exhibited a characteristic (S-curve maturation pattern with exponential growth between statistically defined technology initiation and established points. The median initiation was 1974, with a median of 25 years to the established point, 28 years to first clinical trials, and 36 years to FDA approval. No products were approved before the established point, and development timelines were significantly longer when the clinical trials began before this point (11.5 vs 8.5 years, p<0.0005. Technological maturation represents the longest stage of translation, and significantly impacts the efficiency of drug development.

  19. 5 CFR 7901.102 - Prior approval for outside employment.

    Science.gov (United States)

    2010-01-01

    ... ETHICAL CONDUCT FOR EMPLOYEES OF THE TENNESSEE VALLEY AUTHORITY § 7901.102 Prior approval for outside... or designee. The written request shall be submitted through the employee's supervisor or human resource office and shall, at a minimum, identify the employer or other person for whom the services are to...

  20. 7 CFR 1735.94 - Final approval and closing procedure.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Requirements for All Acquisitions and Mergers § 1735.94 Final approval and closing procedure. (a) Legal documents relating to the acquisition or merger, including copies of required franchises, commission orders...