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Sample records for bfgf-modified bmmscs enhance

  1. Pulsed electromagnetic fields promote survival and neuronal differentiation of human BM-MSCs.

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    Urnukhsaikhan, Enerelt; Cho, Hyunjin; Mishig-Ochir, Tsogbadrakh; Seo, Young-Kwon; Park, Jung-Kueg

    2016-04-15

    Pulsed electromagnetic fields (PEMF) are known to affect biological properties such as differentiation, regulation of transcription factor and cell proliferation. However, the cell-protective effect of PEMF exposure is largely unknown. The aim of this study is to understand the mechanisms underlying PEMF-mediated suppression of apoptosis and promotion of survival, including PEMF-induced neuronal differentiation. Treatment of induced human BM-MSCs with PEMF increased the expression of neural markers such as NF-L, NeuroD1 and Tau. Moreover, treatment of induced human BM-MSCs with PEMF greatly decreased cell death in a dose- and time-dependent manner. There is evidence that Akt and Ras are involved in neuronal survival and protection. Activation of Akt and Ras results in the regulation of survival proteins such as Bad and Bcl-xL. Thus, the Akt/Ras signaling pathway may be a desirable target for enhancing cell survival and treatment of neurological disease. Our analyses indicated that PEMF exposure dramatically increased the activity of Akt, Rsk, Creb, Erk, Bcl-xL and Bad via phosphorylation. PEMF-dependent cell protection was reversed by pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). Our data suggest that the PI3K/Akt/Bad signaling pathway may be a possible mechanism for the cell-protective effects of PEMF. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. In vitro reprogramming of rat bmMSCs into pancreatic endocrine-like cells.

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    Li, Hong-Tu; Jiang, Fang-Xu; Shi, Ping; Zhang, Tao; Liu, Xiao-Yu; Lin, Xue-Wen; San, Zhong-Yan; Pang, Xi-Ning

    2017-02-01

    Islet transplantation provides curative treatments to patients with type 1 diabetes, but donor shortage restricts the broad use of this therapy. Thus, generation of alternative transplantable cell sources is intensively investigated worldwide. We previously showed that bone marrow-derived mesenchymal stem cells (bmMSCs) can be reprogrammed to pancreatic-like cells through simultaneously forced suppression of Rest/Nrsf (repressor element-1 silencing transcription factor/neuronal restrictive silencing factor) and Shh (sonic hedgehog) and activation of Pdx1 (pancreas and duodenal transcription factor 1). We here aimed to reprogram bmMSCs further along the developmental pathway towards the islet lineages by improving our previous strategy and by overexpression of Ngn3 (neurogenin 3) and NeuroD1 (neurogenic differentiation 1), critical regulators of the development of endocrine pancreas. We showed that compared to the previous protocol, the overexpression of only Pdx1 and Ngn3 reprogrammed bmMSCs into cells with more characteristics of islet endocrine lineages verified with bioinformatic analyses of our RNA-Seq datasets. These analyses indicated 2325 differentially expressed genes including those involved in the pancreas and islet development. We validated with qRT-PCR analysis selective genes identified from the RNA-Seq datasets. Thus, we reprogrammed bmMSCs into islet endocrine-like cells and advanced the endeavor to generate surrogate functional insulin-secreting cells.

  3. Effects of pulsed 2.856 GHz microwave exposure on BM-MSCs isolated from C57BL/6 mice.

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    Changzhen Wang

    Full Text Available The increasing use of microwave devices over recent years has meant the bioeffects of microwave exposure have been widely investigated and reported. However the exact biological fate of bone marrow MSCs (BM-MSCs after microwave radiation remains unknown. In this study, the potential cytotoxicity on MSC proliferation, apoptosis, cell cycle, and in vitro differentiation were assayed following 2.856 GHz microwave exposure at a specific absorption rate (SAR of 4 W/kg. Importantly, our findings indicated no significant changes in cell viability, cell division and apoptosis after microwave treatment. Furthermore, we detected no significant effects on the differentiation ability of these cells in vitro, with the exception of reduction in mRNA expression levels of osteopontin (OPN and osteocalcin (OCN. These findings suggest that microwave treatment at a SAR of 4 W/kg has undefined adverse effects on BM-MSCs. However, the reduced-expression of proteins related to osteogenic differentiation suggests that microwave can the influence at the mRNA expression genetic level.

  4. Effects of Pulsed 2.856 GHz Microwave Exposure on BM-MSCs Isolated from C57BL/6 Mice

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    Wang, Changzhen; Wang, Xiaoyan; Zhou, Hongmei; Dong, Guofu; Guan, Xue; Wang, Lifeng; Xu, Xinping; Wang, Shuiming; Chen, Peng; Peng, Ruiyun; Hu, Xiangjun

    2015-01-01

    The increasing use of microwave devices over recent years has meant the bioeffects of microwave exposure have been widely investigated and reported. However the exact biological fate of bone marrow MSCs (BM-MSCs) after microwave radiation remains unknown. In this study, the potential cytotoxicity on MSC proliferation, apoptosis, cell cycle, and in vitro differentiation were assayed following 2.856 GHz microwave exposure at a specific absorption rate (SAR) of 4 W/kg. Importantly, our findings indicated no significant changes in cell viability, cell division and apoptosis after microwave treatment. Furthermore, we detected no significant effects on the differentiation ability of these cells in vitro, with the exception of reduction in mRNA expression levels of osteopontin (OPN) and osteocalcin (OCN). These findings suggest that microwave treatment at a SAR of 4 W/kg has undefined adverse effects on BM-MSCs. However, the reduced-expression of proteins related to osteogenic differentiation suggests that microwave can the influence at the mRNA expression genetic level. PMID:25658708

  5. Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells enhances the recruitment of CD11b{sup +} myeloid cells to the lungs and facilitates B16-F10 melanoma colonization

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    Souza, Lucas E.B., E-mail: lucasebsouza@usp.br [Department of Clinical Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil); Hemotherapy Center of Ribeirão Preto, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil); Almeida, Danilo C., E-mail: gudaalmeida@gmail.com [Department of Medicine – Nephrology, Laboratory of Clinical and Experimental Immunology, Federal University of São Paulo, São Paulo, SP (Brazil); Yaochite, Juliana N.U., E-mail: ueda.juliana@gmail.com [Department of Biochemistry and Immunology, Basic and Applied Immunology Program, School of Medicine of Ribeirão Preto, University of São Paulo (Brazil); Covas, Dimas T., E-mail: dimas@fmrp.usp.br [Department of Clinical Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil); Hemotherapy Center of Ribeirão Preto, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil); Fontes, Aparecida M., E-mail: aparecidamfontes@usp.br [Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil)

    2016-07-15

    The discovery that the regenerative properties of bone marrow multipotent mesenchymal stromal cells (BM-MSCs) could collaterally favor neoplastic progression has led to a great interest in the function of these cells in tumors. However, the effect of BM-MSCs on colonization, a rate-limiting step of the metastatic cascade, is unknown. In this study, we investigated the effect of BM-MSCs on metastatic outgrowth of B16-F10 melanoma cells. In in vitro experiments, direct co-culture assays demonstrated that BM-MSCs stimulated the proliferation of B16-F10 cells in a dose-dependent manner. For in vivo experiments, luciferase-expressing B16-F10 cells were injected through tail vein and mice were subsequently treated with four systemic injections of BM-MSCs. In vivo bioluminescent imaging during 16 days demonstrated that BM-MSCs enhanced the colonization of lungs by B16-F10 cells, which correlated with a 2-fold increase in the number of metastatic foci. Flow cytometry analysis of lungs demonstrated that although mice harboring B16-F10 metastases displayed more endothelial cells, CD4 T and CD8 T lymphocytes in the lungs in comparison to metastases-free mice, BM-MSCs did not alter the number of these cells. Interestingly, BM-MSCs inoculation resulted in a 2-fold increase in the number of CD11b{sup +} myeloid cells in the lungs of melanoma-bearing animals, a cell population previously described to organize “premetastatic niches” in experimental models. These findings indicate that BM-MSCs provide support to B16-F10 cells to overcome the constraints that limit metastatic outgrowth and that these effects might involve the interplay between BM-MSCs, CD11b{sup +} myeloid cells and tumor cells. - Highlights: • BM-MSCs enhanced B16-F10 proliferation in a dose-dependent manner in vitro. • BM-MSCs facilitated lung colonization by B16-F10 melanoma cells. • BM-MSCs administration did not alter the number of endothelial cells and T lymphocytes in the lungs. • BM-MSCs enhanced

  6. Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.

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    Zhang, Mingzi; Ahn, Woosung; Kim, Sumin; Hong, Hyun Sook; Quan, Chengshi; Son, Youngsook

    2017-11-01

    The aim of this study was to evaluate the angiogenicity of a combination of BM-EPCs and BM-MSCs in vitro in the presence of SP and its working mechanism. BM-MSCs and BM-EPCs were cocultured with or without SP. ELISA and RT-PCR were performed to detect angiogenic factors such as VEGF and PDGF-BB. N-cadherin was detected by Western blot analysis. The tubular network-forming ability was evaluated by a Matrigel tube-forming assay. BM-EPCs coculture with BM-MSCs strongly stimulated the recruitment of BM-MSCs onto the BM-EPC-generated endothelial tubular network. Upon SP treatment, endothelial branching point, tubule length, and tubular recruitment of BM-MSCs were further increased and stabilized. The coculture of BM-EPCs and BM-MSCs synergistically stimulated expression of VEGF, VEGF receptor, N-cadherin, and PDGF-BB, all of which were further enhanced by SP treatment. Blockade of PDGF-BB by its functional blocking antibodies markedly reduced the BM-MSC incorporation into the endothelial tubules. SP-pretreated BM-MSCs were preferentially incorporated into the preformed BM-EPC tubular network. BM-EPCs along with SP promote the pericyte-like coverage of BM-MSCs on endothelial tubules possibly through the induction of PDGF-BB. © 2017 John Wiley & Sons Ltd.

  7. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis.

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    Fan, Lihong; Zhang, Chen; Yu, Zefeng; Shi, Zhibin; Dang, Xiaoqian; Wang, Kunzheng

    2015-12-01

    Osteonecrosis of the femoral head may be a disease resulting from abnormal proliferation or differentiation of mesenchymal stem cells. The present investigation explored the novel strategy of hypoxia-preconditioned BMMSCs to reverse the impairment of osteonecrosis BMMSCs and enhance the therapeutic potential of hypoxia-treated BMMSC transplantation. BMMSCs from the anterior superior iliac spine region of osteonecrosis rabbit were cultured under 20% O2 or 2% O2 conditions. Normal BMMSCs were cultured under 20% O2 condition as control. Growth factors secreted were examined by enzyme-linked immunosorbent assay. 20% O2 or 2% O2 BMMSCs were injected into the femoral head of rabbits after core decompression. Cell viability and apoptosis were assessed in vitro, and TUNEL staining of the femoral head was analyzed after transplantation. Angiogenesis (capillary-like structure formation, CD31 immunohistochemical staining and ink infusion angiography) and osteogenesis (Alizarin red-S staining, micro-CT scanning and OCN immunohistochemical staining) tests were conducted as well. 2% O2 exposure up-regulated growth factor secretion in BMMSCs. Apoptosis in 2% O2 group was lower when compared with that in 20% O2 osteonecrosis group. Cell viability in 2% O2 was significantly higher when compared with that in 20% O2 osteonecrosis group. Growth factor secretion, cell viability, apoptosis, capillary-like structure formation, Alizarin red-S staining, and ALP staining showed no difference between the 2% O2 BMMSC and normal BMMSC groups. Transplantation of 2% O2 versus 20% O2 mesenchymal stem cells after core decompression resulted in an increase in angiogenesis function and a decrease in local tissue apoptosis. Our study also found that osteogenesis function was improved after hypoxic stem cell transplantation. Hypoxic preconditioning of BMMSCs is an effective means of reversing the impairment of osteonecrosis BMMSCs, promoting their regenerative capability and therapeutic potential for

  8. Positive effects of bFGF modified rat amniotic epithelial cells transplantation on transected rat optic nerve.

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    Jia-Xin Xie

    Full Text Available Effective therapy for visual loss caused by optic nerve injury or diseases has not been achieved even though the optic nerve has the regeneration potential after injury. This study was designed to modify amniotic epithelial cells (AECs with basic fibroblast growth factor (bFGF gene, preliminarily investigating its effect on transected optic nerve.A human bFGF gene segment was delivered into rat AECs (AECs/hbFGF by lentiviral vector, and the gene expression was examined by RT-PCR and ELISA. The AECs/hbFGF and untransfected rat AECs were transplanted into the transected site of the rat optic nerve. At 28 days post transplantation, the survival and migration of the transplanted cells was observed by tracking labeled cells; meanwhile retinal ganglion cells (RGCs were observed and counted by employing biotin dextran amine (BDA and Nissl staining. Furthermore, the expression of growth associated protein 43 (GAP-43 within the injury site was examined with immunohistochemical staining.The AECs/hbFGF was proven to express bFGF gene and secrete bFGF peptide. Both AECs/hbFGF and AECs could survive and migrate after transplantation. RGCs counting implicated that RGCs numbers of the cell transplantation groups were significantly higher than that of the control group, and the AECs/hbFGF group was significantly higher than that of the AECs group. Moreover GAP-43 integral optical density value in the control group was significantly lower than that of the cell transplantation groups, and the value in the AECs/hbFGF group was significantly higher than that of the AECs group.AECs modified with bFGF could reduce RGCs loss and promote expression of GAP-43 in the rat optic nerve transected model, facilitating the process of neural restoration following injury.

  9. Effect of Allogeneic Bone Marrow-mesenchymal Stem Cells (BM-MSCs) to Accelerate Burn Healing of Rat on the Expression of Collagen Type I and Integrin α2β1.

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    Revilla, Gusti; Darwin, Eryati; Yanwirasti; Rantam, Fedik A

    Burn is a public health problem, it causes physical disability even death. Treatment of burn wound has been conducted in various ways, but the satisfactory healing has not been provided. Bone marrow-derived mesenchymal stem cells (BM-MSCs) treatment is one of attempt to burn recovery, accelerate wound healing and angiogenesis. This study aimed to investigate the effect of allogeneic BM-MSC treatment on the expression of collagen type I and integrin α2β1 in burn skin tissue of rat observed on day 14. Twelve Wistar rats divided into two groups, control group (injected with phospate buffer solution) and treatment group (injected with BM-MSC). Rat was anaesthetized with xylazine and ketamine (ratio 1:1), fur of rat's back was shaved and full thickness burn was made by boiling plate in hot water for 30 min and patched on the back for 20 min. The burns were covered by tegaderm film and elastomult haft. Antalgin as an analgetic was injected to rats during observation process. Burns of rat was observed on day 14. In this study one-way analysis of variance test and Tukey as a further test were analyzed. The results showed that the healing time of allogeneic BM-MSC treatment on burn skin tissue rats was faster, the thickness of collagen type I in burn skin tissue of rats was thicker (0.977 μm) than controls (0.475 μm) and statistically demonstrated significant differences (p = 0.000). The average percentage of integrin α2β1 expression was higher (2.94%) than control group (2.34%), but the differences were not statistically significant (p = 0.176). The study concluded that BM-MSC treatment was able to accelerate the healing process of burns by increasing the thickness of the collagen and the percentage of integrin α2β1, thus accelerated the cell migration involved during wound healing.

  10. Silk fibroin/gelatin–chondroitin sulfate–hyaluronic acid effectively enhances in vitro chondrogenesis of bone marrow mesenchymal stem cells

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    Sawatjui, Nopporn [Biomedical Sciences, Graduate School, Khon Kaen University, Khon Kaen 40002 (Thailand); Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002 (Thailand); Damrongrungruang, Teerasak [Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002 (Thailand); Leeanansaksiri, Wilairat [Stem Cell Therapy and Transplantation Research Group, Suranaree University of Technology, Nakhon Ratchasima 30000 (Thailand); School of Microbiology, Suranaree University of Technology, Nakhon Ratchasima 30000 (Thailand); Jearanaikoon, Patcharee [Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002 (Thailand); Hongeng, Suradej [Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400 (Thailand); Limpaiboon, Temduang, E-mail: temduang@kku.ac.th [Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002 (Thailand)

    2015-07-01

    Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin–chondroitin sulfate–hyaluronic acid (SF–GCH) scaffold and showed that it could promote proliferation of human bone marrow mesenchymal stem cells (BM-MSCs). This study aimed to evaluate its biological performance as a new biomimetic material for chondrogenic induction of BM-MSCs in comparison to an SF scaffold and conventional pellet culture. We found that the SF–GCH scaffold significantly enhanced the proliferation and chondrogenic differentiation of BM-MSCs compared to the SF scaffold and pellet culture in which the production of sulfated glycoaminoglycan was increased in concordance with the up-regulation of chondrogenic-specific gene markers. Our findings indicate the significant role of SF–GCH by providing a supportive structure and the mimetic cartilage environment for chondrogenesis which enables cartilage regeneration. Thus, our fabricated SF–GCH scaffold may serve as a potential biomimetic material for cartilage tissue engineering. - Highlights: • SF–GCH scaffold enhances proliferation and chondrogenic differentiation of BM-MSCs. • SF–GCH acts as a supportive and biomimetic material for BM-MSC chondrogenesis. • SF–GCH is a potential biomimetic scaffold suitable for cartilage tissue engineering.

  11. Silk fibroin/gelatin–chondroitin sulfate–hyaluronic acid effectively enhances in vitro chondrogenesis of bone marrow mesenchymal stem cells

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    Sawatjui, Nopporn; Damrongrungruang, Teerasak; Leeanansaksiri, Wilairat; Jearanaikoon, Patcharee; Hongeng, Suradej; Limpaiboon, Temduang

    2015-01-01

    Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin–chondroitin sulfate–hyaluronic acid (SF–GCH) scaffold and showed that it could promote proliferation of human bone marrow mesenchymal stem cells (BM-MSCs). This study aimed to evaluate its biological performance as a new biomimetic material for chondrogenic induction of BM-MSCs in comparison to an SF scaffold and conventional pellet culture. We found that the SF–GCH scaffold significantly enhanced the proliferation and chondrogenic differentiation of BM-MSCs compared to the SF scaffold and pellet culture in which the production of sulfated glycoaminoglycan was increased in concordance with the up-regulation of chondrogenic-specific gene markers. Our findings indicate the significant role of SF–GCH by providing a supportive structure and the mimetic cartilage environment for chondrogenesis which enables cartilage regeneration. Thus, our fabricated SF–GCH scaffold may serve as a potential biomimetic material for cartilage tissue engineering. - Highlights: • SF–GCH scaffold enhances proliferation and chondrogenic differentiation of BM-MSCs. • SF–GCH acts as a supportive and biomimetic material for BM-MSC chondrogenesis. • SF–GCH is a potential biomimetic scaffold suitable for cartilage tissue engineering

  12. Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice.

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    Lei Chen

    Full Text Available Growing evidence indicates that bone marrow-derived mesenchymal stem cells (BM-MSCs enhance wound repair via paracrine. Because the extent of environmental oxygenation affects the innate characteristics of BM-MSCs, including their stemness and migration capacity, the current study set out to elucidate and compare the impact of normoxic and hypoxic cell-culture conditions on the expression and secretion of BM-MSC-derived paracrine molecules (e.g., cytokines, growth factors and chemokines that hypothetically contribute to cutaneous wound healing in vivo. Semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR and enzyme-linked immunosorbent assay (ELISA analyses of normoxic and hypoxic BM-MSCs and their conditioned medium fractions showed that the stem cells expressed and secreted significantly higher amounts of basic fibroblast growth factor (bFGF,vascular endothelial growth factor A (VEGF-A interleukin 6 (IL-6 and interleukin 8 (IL-8 under hypoxic conditions. Moreover, hypoxic BM-MSC-derived conditioned medium (hypoCM vs. normoxic BM-MSC-derived conditioned medium (norCM or vehicle control medium significantly enhanced the proliferation of keratinocytes, fibroblasts and endothelial cells, the migration of keratinocytes, fibroblasts, endothelial cells and monocytes, and the formation of tubular structures by endothelial cells cultured on Matrigel matrix. Consistent with these in vitro results, skin wound contraction was significantly accelerated in Balb/c nude mice treated with topical hypoCM relative to norCM or the vehicle control. Notably increased in vivo cell proliferation, neovascularization as well as recruitment of inflammatory macrophages and evidently decreased collagen I, and collagen III were also found in the hypoCM-treated group. These findings suggest that BM-MSCs promote murine skin wound healing via hypoxia-enhanced paracrine.

  13. Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.

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    Mitkari, Bhimashankar; Nitzsche, Franziska; Kerkelä, Erja; Kuptsova, Kristina; Huttunen, Joanna; Nystedt, Johanna; Korhonen, Matti; Jolkkonen, Jukka

    2014-02-01

    Intravascular cell therapy is a promising approach for the treatment of stroke. However, high accumulation of cells to lungs and other filtering organs is a major concern after intravenous (i.v.) cell transplantation. This can be circumvented by intra-arterial (i.a.) cell infusion, which improves homing of cells to the injured brain. We studied the effect of i.a. delivery of human bone marrow-derived mesenchymal cells (BMMSCs) on behavioral and histological outcome in rats after middle cerebral artery occlusion (MCAO). Sixty male Wistar rats were subjected to transient MCAO (60 min) or sham-operation. BMMSCs (1×10(6)) were infused into the external carotid artery on postoperative day 2 or 7. Histology performed after a 42-day follow-up did not detect any human cells (MAB1281) in the ischemic brain. Endothelial cell staining with RECA-1 revealed a significant increase in the number of blood vessels in the perilesional cortex in MCAO rats treated with cells on postoperative day 7. Behavioral recovery as assessed in three tests, sticky label, cylinder and Montoya's staircase, was not improved by human BMMSCs during the follow-up. In conclusion, human BMMSCs did not improve functional recovery in MCAO rats despite effective initial homing to the ischemic hemisphere and enhanced angiogenesis, when strict behavioral tests not affected by repeated testing and compensation were utilized. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells

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    Yong-Xin Sun

    2015-01-01

    Full Text Available Bone marrow derived mesenchymal stem cells (BM-MSCs are considered as the most promising cells source for bone engineering. Cannabinoid (CB receptors play important roles in bone mass turnover. The aim of this study is to test if activation of CB2 receptor by chemical agonist could enhance the osteogenic differentiation and mineralization in bone BM-MSCs. Alkaline phosphatase (ALP activity staining and real time PCR were performed to test the osteogenic differentiation. Alizarin red staining was carried out to examine the mineralization. Small interference RNA (siRNA was used to study the role of CB2 receptor in osteogenic differentiation. Results showed activation of CB2 receptor increased ALP activity, promoted expression of osteogenic genes, and enhanced deposition of calcium in extracellular matrix. Knockdown of CB2 receptor by siRNA inhibited ALP activity and mineralization. Results of immunofluorescent staining showed that phosphorylation of p38 MAP kinase is reduced by knocking down of CB2 receptor. Finally, bone marrow samples demonstrated that expression of CB2 receptor is much lower in osteoporotic patients than in healthy donors. Taken together, data from this study suggested that activation of CB2 receptor plays important role in osteogenic differentiation of BM-MSCs. Lack of CB2 receptor may be related to osteoporosis.

  15. Silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid effectively enhances in vitro chondrogenesis of bone marrow mesenchymal stem cells.

    Science.gov (United States)

    Sawatjui, Nopporn; Damrongrungruang, Teerasak; Leeanansaksiri, Wilairat; Jearanaikoon, Patcharee; Hongeng, Suradej; Limpaiboon, Temduang

    2015-01-01

    Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid (SF-GCH) scaffold and showed that it could promote proliferation of human bone marrow mesenchymal stem cells (BM-MSCs). This study aimed to evaluate its biological performance as a new biomimetic material for chondrogenic induction of BM-MSCs in comparison to an SF scaffold and conventional pellet culture. We found that the SF-GCH scaffold significantly enhanced the proliferation and chondrogenic differentiation of BM-MSCs compared to the SF scaffold and pellet culture in which the production of sulfated glycoaminoglycan was increased in concordance with the up-regulation of chondrogenic-specific gene markers. Our findings indicate the significant role of SF-GCH by providing a supportive structure and the mimetic cartilage environment for chondrogenesis which enables cartilage regeneration. Thus, our fabricated SF-GCH scaffold may serve as a potential biomimetic material for cartilage tissue engineering. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Topically Delivered Adipose Derived Stem Cells Show an Activated-Fibroblast Phenotype and Enhance Granulation Tissue Formation in Skin Wounds

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    Hong, Seok Jong; Xu, Wei; Leung, Kai P.; Mustoe, Thomas A.; Galiano, Robert D.

    2013-01-01

    Multipotent mesenchymal stem cells (MSCs) are found in various tissues and can proliferate extensively in vitro. MSCs have been used in preclinical animal studies and clinical trials in many fields. Adipose derived stem cells (ASCs) have several advantages compared to other MSCs for use in cell-based treatments because they are easy to isolate with relative abundance. However, quantitative approaches for wound repair using ASCs have been limited because of lack of animal models which allow for quantification. Here, we addressed the effect of topically delivered ASCs in wound repair by quantitative analysis using the rabbit ear model. We characterized rabbit ASCs, and analyzed their multipotency in comparison to bone marrow derived-MSCs (BM-MSCs) and dermal fibroblasts (DFs) in vitro. Topically delivered ASCs increased granulation tissue formation in wounds when compared to saline controls, whereas BM-MSCs or DFs did not. These studies suggest that ASCs and BM-MSCs are not identical, though they have similar surface markers. We found that topically delivered ASCs are engrafted and proliferate in the wounds. We showed that transplanted ASCs exhibited activated fibroblast phenotype, increased endothelial cell recruitment, and enhanced macrophage recruitment in vivo. PMID:23383253

  17. Enhanced Cellular Uptake of Silica-Coated Magnetite Nanoparticles Compared with PEG-Coated Ones in Stem Cells.

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    Lee, Dong Heon; Kang, Myunggoo; Lee, Hong Jai; Kim, Jeong Ah; Choi, Yun-Kyong; Cho, Hyunjin; Park, Jung-Keug; Park, Tai Hyun; Jung, Hyun

    2015-08-01

    Monodispersed magnetite (Fe3O4) nanoparticles (NPs) were prepared through the thermal decomposition method. The obtained NPs were surface modified with silica (SiO2) and polyethylene glycol (PEG), to enhance their stability in aqueous environment and their cellular uptake efficiency for biomedical applications. The NPs were characterized by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared (FT-IR) spectroscopy, and dynamic light scattering (DLS). The cytotoxicity of these NPs on bone marrow mesenchymal stem cells (BM-MSCs) was measured by MTT assay (cell viability test) at various concentrations (2, 5, 12.5, 25, and 50 µg/mL). The cells remained more than 90% viable at concentrations as high as 50 µg/mL. To compare the cellular uptake efficiency, these NPs were treated in BM-MSCs and the Fe concentration within the cells was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES) analysis. The uptake process displayed a time- and dose-dependency. The uptake amount of SiO2-coated Fe3O4 (Fe3O4@SiO2) NPs was about 10 times higher than that of the PEG-coated ones (Fe3O4@PEG).

  18. Early osteoinductive human bone marrow mesenchymal stromal/stem cells support an enhanced hematopoietic cell expansion with altered chemotaxis- and adhesion-related gene expression profiles

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    Sugino, Noriko [Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 (Japan); Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Miura, Yasuo, E-mail: ym58f5@kuhp.kyoto-u.ac.jp [Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Yao, Hisayuki [Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Iwasa, Masaki; Fujishiro, Aya [Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Division of Gastroenterology and Hematology, Shiga University of Medical Science, Shiga 520-2192 (Japan); Fujii, Sumie [Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 (Japan); Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Hirai, Hideyo [Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan); Takaori-Kondo, Akifumi [Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 (Japan); Ichinohe, Tatsuo [Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553 (Japan); Maekawa, Taira [Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto 606-8507 (Japan)

    2016-01-22

    Bone marrow (BM) microenvironment has a crucial role in supporting hematopoiesis. Here, by using a microarray analysis, we demonstrate that human BM mesenchymal stromal/stem cells (MSCs) in an early osteoinductive stage (e-MSCs) are characterized by unique hematopoiesis-associated gene expression with an enhanced hematopoiesis-supportive ability. In comparison to BM-MSCs without osteoinductive treatment, gene expression in e-MSCs was significantly altered in terms of their cell adhesion- and chemotaxis-related profiles, as identified with Gene Ontology and Gene Set Enrichment Analysis. Noteworthy, expression of the hematopoiesis-associated molecules CXCL12 and vascular cell adhesion molecule 1 was remarkably decreased in e-MSCs. e-MSCs supported an enhanced expansion of CD34{sup +} hematopoietic stem and progenitor cells, and generation of myeloid lineage cells in vitro. In addition, short-term osteoinductive treatment favored in vivo hematopoietic recovery in lethally irradiated mice that underwent BM transplantation. e-MSCs exhibited the absence of decreased stemness-associated gene expression, increased osteogenesis-associated gene expression, and apparent mineralization, thus maintaining the ability to differentiate into adipogenic cells. Our findings demonstrate the unique biological characteristics of e-MSCs as hematopoiesis-regulatory stromal cells at differentiation stage between MSCs and osteoprogenitor cells and have significant implications in developing new strategy for using pharmacological osteoinductive treatment to support hematopoiesis in hematopoietic stem and progenitor cell transplantation. - Highlights: • Human BM-MSCs in an early osteoinductive stage (e-MSCs) support hematopoiesis. • Adhesion- and chemotaxis-associated gene signatures are altered in e-MSCs. • Expression of CXCL12 and VCAM1 is remarkably decreased in e-MSCs. • e-MSCs are at differentiation stage between MSCs and osteoprogenitor cells. • Osteoinductive treatment

  19. Tip enhancement

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    Kawata, Satoshi

    2007-01-01

    This book discusses the recent advances in the area of near-field Raman scattering, mainly focusing on tip-enhanced and surface-enhanced Raman scattering. Some of the key features covered here are the optical structuring and manipulations, single molecule sensitivity, analysis of single-walled carbon nanotubes, and analytic applications in chemistry, biology and material sciences. This book also discusses the plasmonic materials for better enhancement, and optical antennas. Further, near-field microscopy based on second harmonic generation is also discussed. Chapters have been written by some of the leading scientists in this field, who present some of their recent work in this field.·Near-field Raman scattering·Tip-enhanced Raman spectroscopy·Surface-enhanced Raman spectroscopy·Nano-photonics·Nanoanalysis of Physical, chemical and biological materials beyond the diffraction limits·Single molecule detection

  20. Speech enhancement

    CERN Document Server

    Benesty, Jacob; Chen, Jingdong

    2006-01-01

    We live in a noisy world! In all applications (telecommunications, hands-free communications, recording, human-machine interfaces, etc.) that require at least one microphone, the signal of interest is usually contaminated by noise and reverberation. As a result, the microphone signal has to be ""cleaned"" with digital signal processing tools before it is played out, transmitted, or stored.This book is about speech enhancement. Different well-known and state-of-the-art methods for noise reduction, with one or multiple microphones, are discussed. By speech enhancement, we mean not only noise red

  1. EDITORIAL: Enhancing nanolithography Enhancing nanolithography

    Science.gov (United States)

    Demming, Anna

    2012-01-01

    Lithography was invented in late 18th century Bavaria by an ambitious young playwright named Alois Senefelder. Senefelder experimented with stone, wax, water and ink in the hope of finding a way of reproducing text so that he might financially gain from a wider distribution of his already successful scripts. His discovery not only facilitated the profitability of his plays, but also provided the world with an affordable printing press that would ultimately democratize the dissemination of art, knowledge and literature. Since Senefelder, experiments in lithography have continued with a range of innovations including the use of electron beams and UV that allow increasingly higher-resolution features [1, 2]. Applications for this have now breached the limits of paper printing into the realms of semiconductor and microelectronic mechanical systems technology. In this issue, researchers demonstrate a technique for fabricating periodic features in poly(3,4-ethylene dioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) [3]. Their method combines field enhancements from silica nanospheres with laser-interference lithography to provide a means of patterning a polymer that has the potential to open the market of low-end, high-volume microelectronics. Laser-interference lithography has already been used successfully in patterning. Researchers in Korea used laser-interference lithography to generate stamps for imprinting a two-dimensional photonic crystal structure into green light emitting diodes (LEDs) [4]. The imprinted patterns comprised depressions 100 nm deep and 180 nm wide with a periodicity of 295 nm. In comparison with unpatterned LEDs, the intensity of photoluminescence was enhanced by a factor of seven in the LEDs that had the photonic crystal structures imprinted in them. The potential of exploiting field enhancements around nanostructures for new technologies has also attracted a great deal of attention. Researchers in the USA and Australia have used the field

  2. Progressivity Enhanced

    Directory of Open Access Journals (Sweden)

    Marko Hren

    2013-09-01

    Full Text Available Rather than a scientific text, the author contributes a concise memorandum from the originator of the idea who has managed the campaign for the conversion of the military barracks into a creative cluster between 1988 and 2002, when he parted ways with Metelkova due to conflicting views on the center’s future. His views shed light on a distant period of time from a perspective of a participant–observer. The information is abundantly supported by primary sources, also available online. However, some of the presented hypotheses are heavily influenced by his personal experiences of xenophobia, elitism, and predatorial behavior, which were already then discernible on the so-called alternative scene as well – so much so that they obstructed the implementation of progressive programs. The author claims that, in spite of the substantially different reality today, the myths and prejudices concerning Metelkova must be done away with in order to enhance its progressive nature. Above all, the paper calls for an objective view on internal antagonisms, mainly originating in deep class divisions between the users. These make a clear distinction between truly marginal ndividuals and the overambitious beau-bourgeois, as the author labels the large part of users of Metelkova of »his« time. On these grounds, he argues for a robust approach to ban all forms of xenophobia and self-ghettoization.

  3. The osteoblastogenesis potential of adipose mesenchymal stem cells in myeloma patients who had received intensive therapy.

    Directory of Open Access Journals (Sweden)

    Hsiu-Hsia Lin

    Full Text Available Multiple myeloma (MM is characterized by advanced osteolytic lesions resulting from the activation of osteoclasts (OCs and inhibition of osteoblasts (OBs. OBs are derived from mesenchymal stem cells (MSCs from the bone marrow (BM, however the pool and function of BMMSCs in MM patients (MM-BMMSCs are reduced by myeloma cells (MCs and cytokines secreted from MCs and related anti-MM treatment. Such reduction in MM-BMMSCs currently cannot be restored by any means. Recently, genetic aberrations of MM-BMMSCs have been noted, which further impaired their differentiation toward OBs. We hypothesize that the MSCs derived from adipose tissue (ADMSCs can be used as alternative MSC sources to enhance the pool and function of OBs. Therefore, the purpose of this study was to compare the osteogenesis ability of paired ADMSCs and BMMSCs in MM patients who had completed intensive therapy. Fifteen MM patients who had received bortezomib-based induction and autologous transplantation were enrolled. At the third month after the transplant, the paired ADMSCs and BMMSCs were obtained and cultured. Compared with the BMMSCs, the ADMSCs exhibited a significantly higher expansion capacity (100% vs 13%, respectively; P = .001 and shorter doubling time (28 hours vs 115 hours, respectively; P = .019. After inducing osteogenic differentiation, although the ALP activity did not differ between the ADMSCs and BMMSCs (0.78 U/µg vs 0.74±0.14 U/µg, respectively; P = .834, the ADMSCs still exhibited higher calcium mineralization, which was determined using Alizarin red S (1029 nmole vs 341 nmole, respectively; P = .001 and von Kossa staining (2.6 E+05 µm2 vs 5 E+04 µm2, respectively; P = .042, than the BMMSCs did. Our results suggested that ADMSCs are a feasible MSC source for enhancing the pool and function of OBs in MM patients who have received intensive therapy.

  4. Low-level laser therapy with helium-neon laser improved viability of osteoporotic bone marrow-derived mesenchymal stem cells from ovariectomy-induced osteoporotic rats

    Science.gov (United States)

    Fallahnezhad, Somaye; Piryaei, Abbas; Tabeie, Faraj; Nazarian, Hamid; Darbandi, Hasan; Amini, Abdoldllah; Mostafavinia, Ataroalsadat; Ghorishi, Seyed Kamran; Jalalifirouzkouhi, Ali; Bayat, Mohammad

    2016-09-01

    The purpose of this study was to evaluate the influences of helium-neon (He-Ne) and infrared (IR) lasers on the viability and proliferation rate of healthy and ovariectomy-induced osteoporotic (OVX) bone marrow mesenchymal stem cells (BMMSCs) in vitro. MSCs harvested from the BM of healthy and OVX rats were culture expanded. He-Ne and IR lasers were applied three times at energy densities of 0.6, 1.2, and 2.4 J/cm2 for BMMSCs. BMMSCs viability and proliferation rate were evaluated by MTT assay on days 2, 4, 6, 14, and 21. The results showed that healthy BMMSCs responded optimally to 0.6 J/cm2 using an IR laser after three times of laser radiation. Moreover, it was found that OVX-BMMSCs responded optimally to 0.6 J/cm2 with He-Ne laser and one-time laser radiation. It is concluded that the low-level laser therapy (LLLT) effect depends on the physiological state of the BMMSCs, type of the laser, wavelength, and number of laser sessions. The biostimulation efficiency of LLLT also depends on the delivered energy density. LLLT can enhance the viability and proliferation rate of healthy and especially osteoporotic autologous BMMSCs, which could be very useful in regenerative medicine.

  5. Does vitamin C have the ability to augment the therapeutic effect of bone marrow-derived mesenchymal stem cells on spinal cord injury?

    Science.gov (United States)

    Salem, Nesrine; Salem, Mohamed Y; Elmaghrabi, Mohammed M; Elawady, Moataz A; Elawady, Mona A; Sabry, Dina; Shamaa, Ashraf; Elkasapy, Abdel-Haleem H; Ibrhim, Noha; Elamir, Azza

    2017-12-01

    Methylprednisolone (MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI). Vitamin C (VC) is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs), as multipotent stem cells, are promising candidates in SCI repair. To evaluate the therapeutic effects of MP, VC and BMMSCs on traumatic SCI, 80 adult male rats were randomly divided into seven groups: control, SCI (SCI induction by weight-drop method), MP (SCI induction, followed by administration of 30 mg/kg MP via the tail vein, once every other 6 hours, for five times), VC (SCI induction, followed by intraperitoneal administration of 100 mg/kg VC once a day, for 28 days), MP + VC (SCI induction, followed by administration of MP and VC as the former), BMMSCs (SCI induction, followed by injection of 3 × 10 6 BMMSCs at the injury site), and BMMSCs + VC (SCI induction, followed by BMMSCs injection and VC administration as the former). Locomotor recovery was assessed using the Basso Mouse Scale. Injured spinal cord tissue was evaluated using hematoxylin-eosin staining and immunohistochemical staining. Expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes was determined using real-time quantitative PCR. BMMSCs intervention better promoted recovery of nerve function of rats with SCI, mitigated nerve cell damage, and decreased expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes than MP and/or VC. More importantly, BMMSCs in combination with VC induced more obvious improvements. These results suggest that VC can enhance the neuroprotective effects of BMMSCs against SCI.

  6. Does vitamin C have the ability to augment the therapeutic effect of bone marrow-derived mesenchymal stem cells on spinal cord injury?

    Directory of Open Access Journals (Sweden)

    Nesrine Salem

    2017-01-01

    Full Text Available Methylprednisolone (MP is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI. Vitamin C (VC is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs, as multipotent stem cells, are promising candidates in SCI repair. To evaluate the therapeutic effects of MP, VC and BMMSCs on traumatic SCI, 80 adult male rats were randomly divided into seven groups: control, SCI (SCI induction by weight-drop method, MP (SCI induction, followed by administration of 30 mg/kg MP via the tail vein, once every other 6 hours, for five times, VC (SCI induction, followed by intraperitoneal administration of 100 mg/kg VC once a day, for 28 days, MP + VC (SCI induction, followed by administration of MP and VC as the former, BMMSCs (SCI induction, followed by injection of 3 × 106 BMMSCs at the injury site, and BMMSCs + VC (SCI induction, followed by BMMSCs injection and VC administration as the former. Locomotor recovery was assessed using the Basso Mouse Scale. Injured spinal cord tissue was evaluated using hematoxylin-eosin staining and immunohistochemical staining. Expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes was determined using real-time quantitative PCR. BMMSCs intervention better promoted recovery of nerve function of rats with SCI, mitigated nerve cell damage, and decreased expression of transforming growth factor-beta, tumor necrosis factor-alpha, and matrix metalloproteinase-2 genes than MP and/or VC. More importantly, BMMSCs in combination with VC induced more obvious improvements. These results suggest that VC can enhance the neuroprotective effects of BMMSCs against SCI.

  7. Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs.

    Science.gov (United States)

    Legendre, Florence; Ollitrault, David; Gomez-Leduc, Tangni; Bouyoucef, Mouloud; Hervieu, Magalie; Gruchy, Nicolas; Mallein-Gerin, Frédéric; Leclercq, Sylvain; Demoor, Magali; Galéra, Philippe

    2017-06-13

    Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed that these BM-MSCs proliferate slowly, are not uniformly positive for stem cell markers, and maintain their multilineage potential throughout multiple passages. The chondrogenic lineage of BM-MSCs was induced in collagen scaffolds, under normoxia or hypoxia, by BMP-2 and/or TGF-β1. The best chondrogenic induction, with the least hypertrophic induction, was obtained with the combination of BMP-2 and TGF-β1 under hypoxia. Differentiated BM-MSCs were then transfected with siRNAs targeting two markers overexpressed in OA chondrocytes, type I collagen and/or HtrA1 protease. siRNAs significantly decreased mRNA and protein levels of type I collagen and HtrA1, resulting in a more typical chondrocyte phenotype, but with frequent calcification of the subcutaneously implanted constructs in a nude mouse model. Our 3D culture model with BMP-2/TGF-β1 and COL1A1/HtrA1 siRNAs was not effective in producing a cartilage-like matrix in vivo. Further optimization is needed to stabilize the chondrocyte phenotype of differentiated BM-MSCs. Nevertheless, this study offers the opportunity to develop a combinatory cellular therapy strategy for cartilage tissue engineering.

  8. Oxygen-enhanced combustion

    CERN Document Server

    Baukal, Charles E

    2013-01-01

    Combustion technology has traditionally been dominated by air/fuel combustion. However, two developments have increased the significance of oxygen-enhanced combustion-new technologies that produce oxygen less expensively and the increased importance of environmental regulations. Advantages of oxygen-enhanced combustion include less pollutant emissions as well as increased energy efficiency and productivity. Oxygen-Enhanced Combustion, Second Edition compiles information about using oxygen to enhance industrial heating and melting processes. It integrates fundamental principles, applications, a

  9. Mammographic Image Enhancement

    International Nuclear Information System (INIS)

    Md Saion Salikin; Asmaliza Hashim; Wan Hazlinda Ismail; Azuhar Ripin; Norriza Mohd Isa; Mak Chee Hoe

    2005-01-01

    Its main aim is to process an image by utilizing enhancement techniques so that the enhanced image is better and more suitable than the original image for specific application. The objective of the project is to enhance the mammography image by using Interactive Data Language (IDL) software with some of the selected enhancement technique. In order to obtain the best enhanced image, the mammograms with different setting are prepared and the best mammography image is selected by using manual mode with technical factors 28 kV and 56.3 mAs namely 12 mA tube current and 0.45 second time exposure. This paper highlights four enhancement techniques that are chosen and the variables of each algorithm of the techniques are determined. The enhancement techniques used are image clipping technique with image clipped 21% at low ends and 5% at high ends, filtering technique with low pass filter, unsharp masking technique by creating a mask using a low pass filter and global histogram equalization. There are 24 technique permutations produced by the four enhancement techniques chosen, according to order of the enhancement technique applied on a particular mammographic image. These technique permutations are applied to the image using IDL. The enhancement technique permutation of histogram equalization, unsharp masking technique, filtering technique and image clipping technique, that produce the best enhanced image is determined qualitatively. The results of enhancement techniques by using IDL are presented in brief in this presentation. (Author)

  10. The angiogenic related functions of bone marrow mesenchymal stem cells are promoted by CBDL rat serum via the Akt/Nrf2 pathway

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Cheng-Cheng; Chen, Bing; Gu, Jian-Teng; Ning, Jiao-Lin; Chen, Lin; Zeng, Jing; Yi, Bin, E-mail: yibin1974@163.com; Lu, Kai-Zhi, E-mail: lukaizhi2010@163.com

    2016-05-15

    Hepatopulmonary syndrome (HPS) is a complication of severe liver disease. It is characterized by an arterial oxygenation defect. Recent studies have demonstrated that pulmonary angiogenesis contributes to the abnormal gas exchange found in HPS. Additionally, mesenchymal stem cells (MSCs) are considered the stable source of VEGF-producing cells and have the potential to differentiate into multiple cell types. However, it has not been determined whether bone marrow mesenchymal stem cells (BM-MSCs) are mobilized and involved in the pulmonary angiogenesis in HPS. In this study, a CFU-F assay showed that the number of peripheral blood MSCs was increased in common bile duct ligation (CBDL) rats; however, there was no significant difference found in the number of BM-MSCs. In vitro, CBDL rat serum induced the overexpression of CXCR4 and PCNA in BM-MSCs. Consistently, the directional migration as well as the proliferation ability of BM-MSCs were enhanced by CBDL rat serum, as determined by a transwell migration and MTT assays. Moreover, the secretion of VEGF by BM-MSCs increased after treatment with CBDL rat serum. We also found that the expression of phospho-Akt, phospho-ERK, and Nrf2 in BM-MSCs was significantly up-regulated by CBDL rat serum in a time dependent manner, and the blockage of the Akt/Nrf2 signalling pathway with an Akt Inhibitor or Nrf2 siRNA, instead of an ERK inhibitor, attenuated the migration, proliferation and paracrine capacity of BM-MSCs. In conclusion, these findings indicated that the number of MSCs increased in the peripheral blood of CBDL rats, and the Akt/Nrf2 pathway plays a vital role in promoting the angiogenic related functions of BM-MSCs, which could be a potent contributor to pulmonary angiogenesis in HPS. - Highlights: • Peripheral blood MSCs was increased in CBDL rats; however, the difference found for the number of BM-MSCs was not significant. • The directional migration, proliferation and ability to secrete VEGF of BM-MSCs were

  11. Lectin-like oxidized LDL receptor-1 expresses in mouse bone marrow-derived mesenchymal stem cells and stimulates their proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Fenxi [Department of Anatomy, Sanquan College, Xinxiang Medical University, Xinxiang 453003 (China); Stem Cell and Biotheraphy Technology Research Center, College of Lifescience and Technology, Xinxiang Medical University, Xinxiang 453003 (China); Wang, Congrui [Stem Cell and Biotheraphy Technology Research Center, College of Lifescience and Technology, Xinxiang Medical University, Xinxiang 453003 (China); Jing, Suhua [ICU Center, The Third Hospital of Xinxiang Medical University, Xinxiang 453003 (China); Ren, Tongming [Department of Anatomy, Sanquan College, Xinxiang Medical University, Xinxiang 453003 (China); Li, Yonghai; Cao, Yulin [Stem Cell and Biotheraphy Technology Research Center, College of Lifescience and Technology, Xinxiang Medical University, Xinxiang 453003 (China); Lin, Juntang, E-mail: juntang.lin@googlemail.com [Stem Cell and Biotheraphy Technology Research Center, College of Lifescience and Technology, Xinxiang Medical University, Xinxiang 453003 (China)

    2013-04-15

    The bone marrow-derived mesenchymal stem cells (bmMSCs) have been widely used in cell transplant therapy, and the proliferative ability of bmMSCs is one of the determinants of the therapy efficiency. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) as a transmembrane protein is responsible for binding, internalizing and degrading oxidized low density lipoprotein (ox-LDL). It has been identified that LOX-1 is expressed in endothelial cells, vascular smooth muscle cells, cardiomyocytes, fibroblasts and monocytes. In these cells, low concentration of ox-LDL (<40 μg/mL) stimulates their proliferation via LOX-1 activation. However, it is poor understood that whether LOX-1 is expressed in bmMSCs and which role it plays. In this study, we investigated the status of LOX-1 expression in bmMSCs and its function on bmMSC proliferation. Our results showed that primary bmMSCs exhibiting a typical fibroblast-like morphology are positive for CD44 and CD90, but negative for CD34 and CD45. LOX-1 in both mRNA and protein levels is highly expressed in bmMSCs. Meanwhile, bmMSCs exhibit a strong potential to take up ox-LDL. Moreover, LOX-1 expression in bmMSCs is upregulated by ox-LDL with a dose- and time-dependent manner. Presence of ox-LDL also enhances the proliferation of bmMSCs. Knockdown of LOX-1 expression significantly inhibits ox-LDL-induced bmMSC proliferation. These findings indicate that LOX-1 plays a role in bmMSC proliferation. - Highlights: ► LOX-1 expresses in bmMSCs and mediates uptake of ox-LDL. ► Ox-LDL stimulates upregulation of LOX-1 in bmMSCs. ► Ox-LDL promotes bmMSC proliferation and expression of Mdm2, phosphor-Akt, phosphor-ERK1/2 and phosphor-NF-κB. ► LOX-1 siRNA inhibits ox-LDL-induced bmMSC proliferation and expression cell survival signals.

  12. Lectin-like oxidized LDL receptor-1 expresses in mouse bone marrow-derived mesenchymal stem cells and stimulates their proliferation

    International Nuclear Information System (INIS)

    Zhang, Fenxi; Wang, Congrui; Jing, Suhua; Ren, Tongming; Li, Yonghai; Cao, Yulin; Lin, Juntang

    2013-01-01

    The bone marrow-derived mesenchymal stem cells (bmMSCs) have been widely used in cell transplant therapy, and the proliferative ability of bmMSCs is one of the determinants of the therapy efficiency. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) as a transmembrane protein is responsible for binding, internalizing and degrading oxidized low density lipoprotein (ox-LDL). It has been identified that LOX-1 is expressed in endothelial cells, vascular smooth muscle cells, cardiomyocytes, fibroblasts and monocytes. In these cells, low concentration of ox-LDL (<40 μg/mL) stimulates their proliferation via LOX-1 activation. However, it is poor understood that whether LOX-1 is expressed in bmMSCs and which role it plays. In this study, we investigated the status of LOX-1 expression in bmMSCs and its function on bmMSC proliferation. Our results showed that primary bmMSCs exhibiting a typical fibroblast-like morphology are positive for CD44 and CD90, but negative for CD34 and CD45. LOX-1 in both mRNA and protein levels is highly expressed in bmMSCs. Meanwhile, bmMSCs exhibit a strong potential to take up ox-LDL. Moreover, LOX-1 expression in bmMSCs is upregulated by ox-LDL with a dose- and time-dependent manner. Presence of ox-LDL also enhances the proliferation of bmMSCs. Knockdown of LOX-1 expression significantly inhibits ox-LDL-induced bmMSC proliferation. These findings indicate that LOX-1 plays a role in bmMSC proliferation. - Highlights: ► LOX-1 expresses in bmMSCs and mediates uptake of ox-LDL. ► Ox-LDL stimulates upregulation of LOX-1 in bmMSCs. ► Ox-LDL promotes bmMSC proliferation and expression of Mdm2, phosphor-Akt, phosphor-ERK1/2 and phosphor-NF-κB. ► LOX-1 siRNA inhibits ox-LDL-induced bmMSC proliferation and expression cell survival signals

  13. In vitro analysis of equine, bone marrow-derived mesenchymal stem cells demonstrates differences within age- and gender-matched horses.

    Science.gov (United States)

    Carter-Arnold, J L; Neilsen, N L; Amelse, L L; Odoi, A; Dhar, M S

    2014-09-01

    Stem cell therapies are used routinely in equine practice. Most published reports characterise stem cells derived from younger horses; however, middle-aged horses are often in athletic performance, and experience degenerative medical conditions. Thus, mesenchymal stem cells (MSCs) from this group should be investigated. To describe differences in in vitro adherence, proliferation and potential for differentiation of equine bone marrow-derived MSCs (equine BMMSCs) harvested from middle-aged (10-13 years old) female donors. Descriptive study of stem cell characteristics. Equine BMMSCs from 6 horses were cultured in vitro and evaluated for viability, proliferation, osteogenesis, chondrogenesis, adipogenesis, cluster-of-differentiation markers and gene expression. Equine BMMSCs from all 6 donors demonstrated fibroblastic, cellular morphology, adherence to plastic and expression of cluster-of-differentiation markers. They varied in their rate of proliferation and trilineage differentiation. The equine BMMSCs of one of 6 donors demonstrated a higher rate of proliferation, enhanced ability for cell passaging and a more robust in vitro differentiation. Comparatively, equine BMMSCs from 2 donors demonstrated a lower rate of proliferation and lack of osteogenic and chondrogenic differentiation. The results of this study confirm that donor-to-donor variation in equine BMMSCs exists and this variation can be documented using in vitro assays. Subjective assessment suggests that the rate of proliferation tends to correlate with differentiation potential. © 2013 EVJ Ltd.

  14. Plasmon enhanced spectroscopy.

    Science.gov (United States)

    Aroca, Ricardo F

    2013-04-21

    Surface enhanced spectroscopy encompasses a broad field of linear and nonlinear optical techniques that arose with the discovery of the surface-enhanced Raman scattering (SERS) effect. SERS enabled ultrasensitive and single molecule detection with molecular fingerprint specificity, opening the door for a large variety of chemical sensing applications. Basically, from the beginning it was realized that the necessary condition for SERS to be observed was the presence of a metallic nanostructure, and with this condition, the optical enhancement found a home in the field of plasmonics. Although plasmonic practitioners claim that SERS is "the most spectacular application of plasmonics", perhaps it is more appropriate to say that the spectacular development of plasmonics is due to SERS. Here is a brief recollection from surface enhanced spectroscopy to plasmon enhanced spectroscopy.

  15. EDITORIAL: Nano-enhanced! Nano-enhanced!

    Science.gov (United States)

    Demming, Anna

    2010-08-01

    In the early 19th century, a series of engineering and scientific breakthroughs by Nicolas Léonard Sadi Carnot, James Watt and many others led to the foundations of thermodynamics and a new pedigree of mechanical designs that reset the standards of engineering efficiency. The result was the industrial revolution. In optical- and electronics- based nanotechnology research, a similarly subtle bargain is being made; we cannot alter the fact that systems have a finite response to external excitations, but what we can do is enhance that response. The promising attributes of ZnO have long been recognised; its large band gap and high exciton binding energy lend it to a number of applications from laser diodes, LEDs, optical waveguides and switches, and acousto-optic applications to sun cream. When this material is grown into nanowires and nanorods, the material gains a whole new dimension, as quantum confinement effects come into play. Discovery of the enhanced radiative recombination, which has potential for exploitation in many optical and opto-electronic applications, drove intensive research into investigating these structures and into finding methods to synthesise them with optimised properties. This research revealed further subtleties in the properties of these materials. One example is the work by researchers in the US reporting synthesis procedures that produced a yield—defined as the weight ratio of ZnO nanowires to the original graphite flakes—of 200%, and which also demonstrated, through photoluminescence analysis of nanowires grown on graphite flakes and substrates, that graphite induces oxygen vacancies during annealing, which enhances the deep-level to near-band-edge emission ratio [1]. Other one-dimensional materials that provide field emission enhancements include carbon nanotubes, and work has been performed to find ways of optimising the emission efficiency from these structures, such as through control of the emitter density [2]. One of the

  16. Ring enhancement in contrast enhancement computed tomography

    International Nuclear Information System (INIS)

    Inatsuki, Shinichi; Hayashi, Kuniaki; Miyake, Hidetoshi

    1979-01-01

    Ring enhancement was examined in 11 lesions, 61 patients, we experienced. The frequency of ring enhancement observed in cerebral abscesses and tumors and the characteristics and the differential points of each disease were obtained. The frequency of ring enhancement was 54% in metastatic cerebral tumor, 56% in glioblastoma and astrocytoma (grade III) and 100% in cerebral abscess. Glioblastoma and astrocytoma (grade III) differed from other diseases in having distorted rings with poor uniform thickness. Although there was a great similarity between the computed tomographic picture of metastatic cerebral tumor and that of cerebral abscess, the ring in cerebral abscess was clearer, thin and uniform, and the peripheral edema in cerebral abscess was weak in general. In cerebral infarct, peripheral edema and mass effect of the ring were not observed or slightly observed, if any. Considering only the characteristics of the rings, there are differences between each diseases, and differentiation seems to be possibly performed. In practice, however, it is not necessarily easy to make a differential diagnosis. Clinical results should be carefully managed. (Kumagai, M.)

  17. Enhancement of HHG yield

    International Nuclear Information System (INIS)

    Serrat, C.; Biegert, J.

    2011-01-01

    A static electric field periodically distributed in space controls and enhances the yield in high harmonic generation. The method is relatively simple to implement and allows tuning from the extreme-ultraviolet to soft X-ray. The radiation yield is selectively enhanced due to symmetry breaking induced by a static electric field on the interaction between the driving laser and the medium. The enhanced spectral region is tuned by varying the periodicity of the static electric field. Simulations predict an increase of more than two orders of magnitude for harmonics in the water window spectral range.

  18. Personal Identity in Enhancement

    Directory of Open Access Journals (Sweden)

    Jana Podroužková

    2015-09-01

    Full Text Available The aim of this paper is to introduce the concept of human enhancement, its methods and its relation to personal identity. Also several approaches to personal identity will be described. Transhumanism is a special think tank supporting human enhancement through modern technologies and some of its representatives claim, that even great changes to human organisms will not affect their personal identity. I will briefly describe the most important means of human enhancment and consider the problem of personal identity for each of them separately.

  19. Medically-enhanced normality

    DEFF Research Database (Denmark)

    Møldrup, Claus; Traulsen, Janine Morgall; Almarsdóttir, Anna Birna

    2003-01-01

    Objective: To consider public perspectives on the use of medicines for non-medical purposes, a usage called medically-enhanced normality (MEN). Method: Examples from the literature were combined with empirical data derived from two Danish research projects: a Delphi internet study and a Telebus......, to optimise economic, working and family conditions. The term "doping" does not cover or explain the use of medicines as enhancement among healthy non-athletes. Conclusion: We recommend wider use of the term medically-enhanced normality as a conceptual framework for understanding and analysing perceptions...... of what is considered rational medicine use in contemporary society....

  20. Enhanced Magnetic Model 2010

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Enhanced Magnetic Model (EMM) extends to degree and order 720, resolving magnetic anomalies down to 56 km wavelength. The higher resolution of the EMM results in...

  1. Enhanced Magnetic Model 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Enhanced Magnetic Model (EMM) extends to degree and order 720, resolving magnetic anomalies down to 56 km wavelength. The higher resolution of the EMM results in...

  2. Ogallala Bedrock Data Enhancement

    Data.gov (United States)

    Kansas Data Access and Support Center — This data set provides an enhanced estimate of the bedrock elevation of the Ogallala Aquifer in Kansas based on lithologic logs from a variety of sources. The data...

  3. Rethinking enhancement in sport.

    Science.gov (United States)

    Miah, Andy

    2006-12-01

    This article explores the arguments surrounding the use of human enhancement technologies in sport, arguing for a reconceptualization of the doping debate. First, it develops an overview and critique of the legislative structures on enhancement. Subsequently, a conceptual framework for understanding the role of technological effects in sport is advanced. Finally, two case studies (hypoxic chambers and gene transfer) receive specific attention, through which it is argued that human enhancement technologies can enrich the practice of elite sports rather than diminish them. In conclusion, it is argued that elite sports are at a pivotal moment in their history as an increasing range of enhancements makes less relevant the protection of the natural human through anti-doping.

  4. Enhanced metabolite generation

    Science.gov (United States)

    Chidambaram, Devicharan [Middle Island, NY

    2012-03-27

    The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor accepts electrons from the microbe after oxidation of the carbon source. Other transfers of electrons can take place to enhance the production of the metabolite, such as acids, biofuels or brewed beverages.

  5. Plasmonic enhancement of electroluminescence

    Science.gov (United States)

    Guzatov, D. V.; Gaponenko, S. V.; Demir, H. V.

    2018-01-01

    Here plasmonic effect specifically on electroluminescence (EL) is studied in terms of radiative and nonradiative decay rates for a dipole near a metal spherical nanoparticle (NP). Contribution from scattering is taken into account and is shown to play a decisive role in EL enhancement owing to pronounced size-dependent radiative decay enhancement and weak size effect on non-radiative counterpart. Unlike photoluminescence where local incident field factor mainly determines the enhancement possibility and level, EL enhancement is only possible by means of quantum yield rise, EL enhancement being feasible only for an intrinsic quantum yield Q0 red-orange range only. Independently of positive effect on quantum yield, metal nanoparticles embedded in an electroluminescent device will improve its efficiency at high currents owing to enhanced overall recombination rate which will diminish manifestation of Auger processes. The latter are believed to be responsible for the known undesirable efficiency droop in semiconductor commercial quantum well based LEDs at higher current. For the same reason plasmonics can diminish quantum dot photodegradation from Auger process induced non-radiative recombination and photoionization thus opening a way to avoid negative Auger effects in emerging colloidal semiconductor LEDs.

  6. Cholesterol Domains Enhance Transfection

    Science.gov (United States)

    Betker, Jamie L.; Kullberg, Max; Gomez, Joe; Anchordoquy, Thomas J.

    2014-01-01

    The formation of cholesterol domains in lipoplexes has been associated with enhanced serum stability and transfection rates both in cell culture and in vivo. This study utilizes the ability of saturated phosphatidylcholines to promote the formation of cholesterol domains at much lower cholesterol contents than have been utilized in previous work. The results show that lipoplexes with identical cholesterol and cationic lipid contents exhibit significantly improved transfection efficiencies when a domain is present, consistent with previous work. In addition, studies assessing transfection rates in the absence of serum demonstrate that the ability of domains to enhance transfection is not dependent on interactions with serum proteins. Consistent with this hypothesis, characterization of the adsorbed proteins composing the corona of these lipoplex formulations did not reveal a correlation between transfection and the adsorption of a specific protein. Finally, we show that the interaction with serum proteins can promote domain formation in some formulations, and thereby result in enhanced transfection only after serum exposure. PMID:23557286

  7. Human freedom and enhancement.

    Science.gov (United States)

    Heilinger, Jan-Christoph; Crone, Katja

    2014-02-01

    Ideas about freedom and related concepts like autonomy and self-determination play a prominent role in the moral debate about human enhancement interventions. However, there is not a single understanding of freedom available, and arguments referring to freedom are simultaneously used to argue both for and against enhancement interventions. This gives rise to misunderstandings and polemical arguments. The paper attempts to disentangle the different distinguishable concepts, classifies them and shows how they relate to one another in order to allow for a more structured and clearer debate. It concludes in identifying the individual underpinnings and the social conditions of choice and decision-making as particularly salient dimensions of freedom in the ethical debate about human enhancement.

  8. Biomedical enhancements as justice.

    Science.gov (United States)

    Nam, Jeesoo

    2015-02-01

    Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie moral obligation to use these new developments for the end goal of promoting social justice. In terms of both range and magnitude, the use of biomedical enhancements will mark a radical advance in how we compensate the most disadvantaged members of society. © 2013 John Wiley & Sons Ltd.

  9. Cavity-enhanced spectroscopies

    CERN Document Server

    van Zee, Roger

    2003-01-01

    ""Cavity-Enhanced Spectroscopy"" discusses the use of optical resonators and lasers to make sensitive spectroscopic measurements. This volume is written by the researcchers who pioneered these methods. The book reviews both the theory and practice behind these spectroscopic tools and discusses the scientific discoveries uncovered by these techniques. It begins with a chapter on the use of optical resonators for frequency stabilization of lasers, which is followed by in-depth chapters discussing cavity ring-down spectroscopy, frequency-modulated, cavity-enhanced spectroscopy, intracavity spectr

  10. Music Enhances Learning.

    Science.gov (United States)

    Campabello, Nicolette; De Carlo, Mary Jane; O'Neil, Jean; Vacek, Mary Jill

    An action research project implemented musical strategies to affect and enhance student recall and memory. The target population was three suburban elementary schools near a major midwestern city: (1) a kindergarten classroom contained 32-38 students; (2) a second grade classroom contained 23 students and five Individualized Education Program…

  11. Heat transfer enhancement

    International Nuclear Information System (INIS)

    Hasatani, Masanobu; Itaya, Yoshinori

    1985-01-01

    In order to develop energy-saving techniques and new energy techniques, and also most advanced techniques by making industrial equipment with high performance, heat transfer performance frequently becomes an important problem. In addition, the improvement of conventional heat transfer techniques and the device of new heat transfer techniques are often required. It is most proper that chemical engineers engage in the research and development for enhancing heat transfer. The research and development for enhancing heat transfer are important to heighten heat exchange efficiency or to cool equipment for preventing overheat in high temperature heat transfer system. In this paper, the techniques of enhancing radiative heat transfer and the improvement of radiative heat transfer characteristics are reported. Radiative heat transfer is proportional to fourth power of absolute temperature, and it does not require any heat transfer medium, but efficient heat-radiation converters are necessary. As the techniques of enhancing radiative heat transfer, the increase of emission and absorption areas, the installation of emissive structures and the improvement of radiative characteristics are discussed. (Kako, I.)

  12. Placebo can enhance creativity.

    Science.gov (United States)

    Rozenkrantz, Liron; Mayo, Avraham E; Ilan, Tomer; Hart, Yuval; Noy, Lior; Alon, Uri

    2017-01-01

    The placebo effect is usually studied in clinical settings for decreasing negative symptoms such as pain, depression and anxiety. There is interest in exploring the placebo effect also outside the clinic, for enhancing positive aspects of performance or cognition. Several studies indicate that placebo can enhance cognitive abilities including memory, implicit learning and general knowledge. Here, we ask whether placebo can enhance creativity, an important aspect of human cognition. Subjects were randomly assigned to a control group who smelled and rated an odorant (n = 45), and a placebo group who were treated identically but were also told that the odorant increases creativity and reduces inhibitions (n = 45). Subjects completed a recently developed automated test for creativity, the creative foraging game (CFG), and a randomly chosen subset (n = 57) also completed two manual standardized creativity tests, the alternate uses test (AUT) and the Torrance test (TTCT). In all three tests, participants were asked to create as many original solutions and were scored for originality, flexibility and fluency. The placebo group showed higher originality than the control group both in the CFG (pcreativity. This strengthens the view that placebo can be used not only to reduce negative clinical symptoms, but also to enhance positive aspects of cognition. Furthermore, we find that the impact of placebo on creativity can be tested by CFG, which can quantify multiple aspects of creative search without need for manual coding. This approach opens the way to explore the behavioral and neural mechanisms by which placebo might amplify creativity.

  13. Enhanced processive cellulases

    Energy Technology Data Exchange (ETDEWEB)

    Adney, William S.; Beckham, Gregg T.; Jarvis, Eric; Himmel, Michael E.; Decker, Stephen R.; Linger, Jeffrey G.; Podkaminer, Kara; Baker, John O.; Taylor, II, Larry; Xu, Qi; Singh, Arjun

    2017-06-20

    Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.

  14. Teaching to Enhance Research

    Science.gov (United States)

    Harland, Tony

    2016-01-01

    In this paper, I present a conceptual argument for "teaching-led research" in which university lecturers construct courses that directly and positively influence their research, while at the same time, safeguard and enhance the student experience. A research-pedagogy for higher education considers the link between teaching and research,…

  15. Fibroblast activation protein (FAP is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation.

    Directory of Open Access Journals (Sweden)

    Kuei-Min Chung

    Full Text Available BACKGROUND: The ability of human bone marrow mesenchymal stem cells (BM-MSCs to migrate and localize specifically to injured tissues is central in developing therapeutic strategies for tissue repair and regeneration. Fibroblast activation protein (FAP is a cell surface serine protease expressed at sites of tissue remodeling during embryonic development. It is also expressed in BM-MSCs, but not in normal tissues or cells. The function of FAP in BM-MSCs is not known. PRINCIPAL FINDINGS: We found that depletion of FAP proteins significantly inhibited the migration of BM-MSCs in a transwell chemotaxis assay. Such impaired migration ability of BM-MSCs could be rescued by re-expressing FAP in these cells. We then demonstrated that depletion of FAP activated intracellular RhoA GTPase. Consistently, inhibition of RhoA activity using a RhoA inhibitor rescued its migration ability. Inhibition of FAP activity with an FAP-specific inhibitor did not affect the activation of RhoA or the migration of BM-MSCs. Furthermore, the inflammatory cytokines interleukin-1beta (IL-1β and transforming growth factor-beta (TGF-β upregulated FAP expression, which coincided with better BM-MSC migration. CONCLUSIONS: Our results indicate FAP plays an important role in the migration of BM-MSCs through modulation of RhoA GTPase activity. The peptidase activity of FAP is not essential for such migration. Cytokines IL-1β and TGF-β upregulate the expression level of FAP and thus enhance BM-MSC migration.

  16. Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.

    Science.gov (United States)

    Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana

    2014-03-01

    Bone marrow-derived mesenchymal stem cells (BM-MSCs) promote gastric cancer in response to gastritis. In culture, BM-MSCs are prone to mutation with continued passage but it is unknown whether a similar process occurs in vivo in response to gastritis. The purpose of this study was to identify the role of chronic gastritis in the transformation of BM-MSCs leading to an activated cancer-promoting phenotype. Age matched C57BL/6 (BL/6) and gastrin deficient (GKO) mice were used for isolation of stomach, serum and mesenchymal stem cells (MSCs) at 3 and 6 months of age. MSC activation was assessed by growth curve analysis, fluorescence-activated cell sorting and xenograft assays. To allow for the isolation of bone marrow-derived stromal cells and assay in response to chronic gastritis, IRG/Vav-1(Cre) mice that expressed both enhanced green fluorescent protein-expressing hematopoietic cells and red fluorescent protein-expressing stromal cells were generated. In a parabiosis experiment, IRG/Vav-1(Cre) mice were paired to either an uninfected Vav-1(Cre) littermate or a BL/6 mouse inoculated with Helicobacter pylori. GKO mice displayed severe atrophic gastritis accompanied by elevated gastric tissue and circulating transforming growth factor beta (TGFβ) by 3 months of age. Compared to BM-MSCs isolated from uninflamed BL/6 mice, BM-MSCs isolated from GKO mice displayed an increased proliferative rate and elevated phosphorylated-Smad3 suggesting active TGFβ signaling. In xenograft assays, mice injected with BM-MSCs from 6-month-old GKO animals displayed tumor growth. RFP+ stromal cells were rapidly recruited to the gastric mucosa of H. pylori parabionts and exhibited changes in gene expression. Gastritis promotes the in vivo activation of BM-MSCs to a phenotype reminiscent of a cancer-promoting cell.

  17. Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Immune-Mediated Liver Injury and Compromise Virus Control During Acute Hepatitis B Virus Infection in Mice.

    Science.gov (United States)

    Qu, Mengmeng; Yuan, Xu; Liu, Dan; Ma, Yuhong; Zhu, Jun; Cui, Jun; Yu, Mengxue; Li, Changyong; Guo, Deyin

    2017-06-01

    Mesenchymal stem cells (MSCs) have been used as therapeutic tools not only for their ability to differentiate toward different cells, but also for their unique immunomodulatory properties. However, it is still unknown how MSCs may affect immunity during hepatitis B virus (HBV) infection. This study was designed to explore the effect of bone marrow-derived MSCs (BM-MSCs) on hepatic natural killer (NK) cells in a mouse model of acute HBV infection. Mice were injected with 1 × 10 6 BM-MSCs, which stained with chloromethyl derivatives of fluorescein diacetate fluorescent probe, 24 h before hydrodynamic injection of viral DNA (pHBV1.3) through the tail vein. In vivo imaging system revealed that BM-MSCs were accumulated in the injured liver, and they attenuated immune-mediated liver injury during HBV infection, as shown by lower alanine aminotransferase levels, reduced proinflammatory cytokine production, and decreased inflammatory cell infiltration in the liver. Importantly, administration of BM-MSCs restrained the increased expression of natural-killer group 2, member D (NKG2D), an important receptor required for NK cell activation in the liver from HBV-infected mice. BM-MSCs also reduced NKG2D expression on NK cells and suppressed the cytotoxicity of NK cells in vitro. Furthermore, BM-MSC-derived transforming growth factor-β1 suppressed NKG2D expression on NK cells. As a consequence, BM-MSC treatment enhanced HBV gene expression and replication in vivo. These results demonstrate that adoptive transfer of BM-MSCs influences innate immunity and limits immune-mediated liver injury during acute HBV infection by suppressing NK cell activity. Meanwhile, the effect of BM-MSCs on prolonging virus clearance needs to be considered in the future.

  18. Defining Human Enhancement

    DEFF Research Database (Denmark)

    Nordberg, Ana

    2017-01-01

    Emerging technologies open the prospect of extraordinary interventions on the human body. These may go beyond what is strictly necessary to sustain health and well-being. While responding to social and ethical challenges of such advances, the Law simultaneously faces the challenge of reflecting...... on the legitimacy to legislate and on whether the existing legal framework is appropriate to address the various concerns. In order to do so, it is crucial to establish clear legal definitions. Precise distinctions between interventions on the human body are intrinsically difficult to formulate. However, subject......-matter definitions are vital legal tools to determine what is currently regulated in established fields of law and whether there is room for a new legal field – Enhancement Law. This paper provides a reflection on the relevance of establishing a legal definition of human enhancement and to what extent different...

  19. Enhanced Microfluidic Electromagnetic Measurements

    Science.gov (United States)

    Giovangrandi, Laurent (Inventor); Ricco, Antonio J. (Inventor); Kovacs, Gregory (Inventor)

    2015-01-01

    Techniques for enhanced microfluidic impedance spectroscopy include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. Flow in the channel is laminar. A dielectric constant of a fluid constituting either sheath flow is much less than a dielectric constant of the core fluid. Electrical impedance is measured in the channel between at least a first pair of electrodes. In some embodiments, enhanced optical measurements include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. An optical index of refraction of a fluid constituting either sheath flow is much less than an optical index of refraction of the core fluid. An optical property is measured in the channel.

  20. Superposition Enhanced Nested Sampling

    Directory of Open Access Journals (Sweden)

    Stefano Martiniani

    2014-08-01

    Full Text Available The theoretical analysis of many problems in physics, astronomy, and applied mathematics requires an efficient numerical exploration of multimodal parameter spaces that exhibit broken ergodicity. Monte Carlo methods are widely used to deal with these classes of problems, but such simulations suffer from a ubiquitous sampling problem: The probability of sampling a particular state is proportional to its entropic weight. Devising an algorithm capable of sampling efficiently the full phase space is a long-standing problem. Here, we report a new hybrid method for the exploration of multimodal parameter spaces exhibiting broken ergodicity. Superposition enhanced nested sampling combines the strengths of global optimization with the unbiased or athermal sampling of nested sampling, greatly enhancing its efficiency with no additional parameters. We report extensive tests of this new approach for atomic clusters that are known to have energy landscapes for which conventional sampling schemes suffer from broken ergodicity. We also introduce a novel parallelization algorithm for nested sampling.

  1. Surface plasmon enhanced LED

    OpenAIRE

    Vučković, Jelena; Lončar, Marko; Painter, Oskar; Scherer, Axel

    2000-01-01

    Summary form only given. We designed and fabricated an LED based on a thin semiconductor membrane (λ/2) with silver mirrors. A large spontaneous emission enhancement and a high modulation speed are obtainable due to the strong localization of the electromagnetic field in the microcavity. The coupling to surface plasmon modes which are subsequently scattered out by means of a grating is used to improve the extraction efficiency of the LED. The bottom mirror is thick and unpatterned. The top mi...

  2. Enhancing radiation biodosimetry capability

    International Nuclear Information System (INIS)

    Alok, A.; Kumar, A.; Kulshrestra, S.; Choudhary, S.; Bhagi, S.; Adhikari, J.S.; Chaudhury, N.K.

    2016-01-01

    Biodosimetry laboratories are necessary for quick and accurate assessment of absorbed radiation dose in suspected individuals for their medical management. The method is based on dicentric chromosomal assay (Gold standard). This assay is completely manual and time consuming, require skill and competency of laboratory staff. There is a necessity of more biodosimetry labs within country and networking within and at international level for enhancing medical preparedness for management of radiation emergency

  3. Enhanced pain syndromes

    Directory of Open Access Journals (Sweden)

    Evelin Diana Goldenberg Meirelles Mariano da Costa

    2008-03-01

    Full Text Available Enhanced pain syndromes have their prevalence increased withold age. Fibromyalgia, among them deserves special attention. Itscauses are still unknown. Fibromyalgia syndrome affects mainlyfemales and is characterized by generalized musculoskeletal pain,fatigue, sleep disturbances, diffuse stiffness and other psychic signsand symptoms. Diagnosis is essentially based on the 1990 AmericanCollege of Rheumatology Classifi cative Criteria. In this chapteraspects related to its treatment and prognosis are also discussed.

  4. Enhanced Attenuation: Chlorinated Organics

    Science.gov (United States)

    2008-04-01

    an electron acceptor. Common substitutes for oxygen are nitrate, sulfate, iron, carbon dioxide, and other organic compounds ( fermentation ). anoxic...that not until the analysis is focused just on the extremely bioavailable VFAs (also called “metabolic acids”: acetic, propionic, butyric , iso- and...I or Type II chlorinated solvent site, Wiedemeier et al. 1998) or if the electron donor supply is enhanced by adding fermentation substrates or

  5. Novelty enhances visual perception.

    Directory of Open Access Journals (Sweden)

    Judith Schomaker

    Full Text Available The effects of novelty on low-level visual perception were investigated in two experiments using a two-alternative forced-choice tilt detection task. A target, consisting of a Gabor patch, was preceded by a cue that was either a novel or a familiar fractal image. Participants had to indicate whether the Gabor stimulus was vertically oriented or slightly tilted. In the first experiment tilt angle was manipulated; in the second contrast of the Gabor patch was varied. In the first, we found that sensitivity was enhanced after a novel compared to a familiar cue, and in the second we found sensitivity to be enhanced for novel cues in later experimental blocks when participants became more and more familiarized with the familiar cue. These effects were not caused by a shift in the response criterion. This shows for the first time that novel stimuli affect low-level characteristics of perception. We suggest that novelty can elicit a transient attentional response, thereby enhancing perception.

  6. Novelty enhances visual perception.

    Science.gov (United States)

    Schomaker, Judith; Meeter, Martijn

    2012-01-01

    The effects of novelty on low-level visual perception were investigated in two experiments using a two-alternative forced-choice tilt detection task. A target, consisting of a Gabor patch, was preceded by a cue that was either a novel or a familiar fractal image. Participants had to indicate whether the Gabor stimulus was vertically oriented or slightly tilted. In the first experiment tilt angle was manipulated; in the second contrast of the Gabor patch was varied. In the first, we found that sensitivity was enhanced after a novel compared to a familiar cue, and in the second we found sensitivity to be enhanced for novel cues in later experimental blocks when participants became more and more familiarized with the familiar cue. These effects were not caused by a shift in the response criterion. This shows for the first time that novel stimuli affect low-level characteristics of perception. We suggest that novelty can elicit a transient attentional response, thereby enhancing perception.

  7. Sleep for cognitive enhancement

    Directory of Open Access Journals (Sweden)

    Susanne eDiekelmann

    2014-04-01

    Full Text Available Sleep is essential for effective cognitive functioning. Loosing even a few hours of sleep can have detrimental effects on a wide variety of cognitive processes such as attention, language, reasoning, decision making, learning and memory. While sleep is necessary to ensure normal healthy cognitive functioning, it can also enhance performance beyond the boundaries of the normal condition. This article discusses the enhancing potential of sleep, mainly focusing on the domain of learning and memory. Sleep is known to facilitate the consolidation of memories learned before sleep as well as the acquisition of new memories to be learned after sleep. According to a widely held model this beneficial effect of sleep relies on the neuronal reactivation of memories during sleep that is associated with sleep-specific brain oscillations (slow oscillations, spindles, ripples as well as a characteristic neurotransmitter milieu. Recent research indicates that memory processing during sleep can be boosted by (i cueing memory reactivation during sleep, (ii stimulating sleep-specific brain oscillations, and (iii targeting specific neurotransmitter systems pharmacologically. Olfactory and auditory cues can be used, for example, to increase reactivation of associated memories during post-learning sleep. Intensifying neocortical slow oscillations (the hallmark of slow wave sleep by electrical or auditory stimulation and modulating specific neurotransmitters such as noradrenaline and glutamate likewise facilitates memory processing during sleep. With this evidence in mind, this article concludes by discussing different methodological caveats and ethical issues that should be considered when thinking about using sleep for cognitive enhancement in everyday applications.

  8. Sweeteners and sweetness enhancers.

    Science.gov (United States)

    Belloir, Christine; Neiers, Fabrice; Briand, Loïc

    2017-07-01

    The current review summarizes and discusses current knowledge on sweeteners and sweetness enhancers. The perception of sweet taste is mediated by the type 1 taste receptor 2 (T1R2)/type 1 taste receptor 3 (T1R3) receptor, which is expressed in the oral cavity, where it provides input on the caloric and macronutrient contents of ingested food. This receptor recognizes all the compounds (natural or artificial) perceived as sweet by people. Sweeteners are highly chemically diverse including natural sugars, sugar alcohols, natural and synthetic sweeteners, and sweet-tasting proteins. This single receptor is also the target for developing novel sweet enhancers. Importantly, the expression of a functional T1R2/T1R3 receptor is described in numerous extraoral tissues. In this review, the physiological impact of sweeteners is discussed. Sweeteners and sweetness enhancers are perceived through the T1R2/T1R3 taste receptor present both in mouth and numerous extraoral tissues. The accumulated knowledge on sugar substitutes raises the issue of potential health effects.

  9. ICRF enhanced potentials

    International Nuclear Information System (INIS)

    Nelson, B.A.

    1987-01-01

    Ion-confining potentials in the Phaedrus tandem mirror are shown to be enhanced over Boltzmann-relations predicted values by radio-frequency (rf) waves in the ion cyclotron range of frequencies (ICRF). The ICRF enhanced potential is larger in the end cell with a lower passing density. Peak potential values decrease with increasing ion endloss current (or central cell density) for a constant rf capacitor bank voltage, and increase with increasing rf-capacitor bank voltage, for a constant ion endloss value (or central cell density). In fully axisymmetric operation, a potential peak is produced in an end cell by the central-cell rf, (with-out end-cell rf) and is found only in the end cell nearer the central-cell antenna. ICRF enhanced potentials are explained as an equilibrium between the electron-collisional filling-in rate and the electron pumping out rate provided by axial time-varying electric fields. Thermal barrier-like potential structures were found in the transition regions between the central cell and end cells, in the fully axisymmetric Phaedrus. Central-cell ICRF trapping effects combined with end-cell μΔ B forces create and pump the barrier potential wells

  10. ICT Enhanced Buildings Potentials

    DEFF Research Database (Denmark)

    Christiansson, Per

    2007-01-01

    component systems that are accessed and integrated in the real world of building use in different contexts. The ICT systems may be physically or virtually embedded in the building. Already in 1982 AT&T established the 'intelligent buildings', IB, concept due to marketing reasons and the Informart building...... with focus on virtual building models support, new services and user environment definitions and development, virtual spaces and augmented reality, intelligent building components, application ontologies, and ICT systems integration to illustrate ICT enhanced buildings potentials and R&D needs.  ...

  11. Helping faculty enhance scholarship.

    Science.gov (United States)

    Hawranik, Pamela; Thorpe, Karran M

    2008-04-01

    Nurse educators face a myriad of challenges (e.g., changing student populations, increased demand for the use of technology, faculty shortages, and facilitating the development of self-confidence and competence in students) as they endeavor to enhance scholarship and quality in nursing education. Scholarship encompasses four separate but integrated elements (i.e., discovery, integration, application, and teaching) that need to be instilled in nursing students to prepare them for diverse roles in the profession of nursing. Implications for nurse educators relate to creating curricula that support scholarship, technological and interprofessional opportunities, and strategies for socializing students into scholarship.

  12. Enhancing LAN performance

    CERN Document Server

    Held, Gilbert

    2004-01-01

    Enhancing LAN Performance, Fourth Edition explains how to connect geographically separated LANs with appropriate bandwidth, the issues to consider when weighing the use of multiport or dualport devices, how to estimate traffic for new networks, the effects of configuration changes on the performance of Ethernet and Token Ring networks, the design of switch-based networks that prevent traffic bottlenecks, and other critical topics. It provides the tools to address these issues in relation to specific network requirements. This volume develops mathematical models of various LAN performance issue

  13. Acoustically enhanced heat transport

    Energy Technology Data Exchange (ETDEWEB)

    Ang, Kar M.; Hung, Yew Mun; Tan, Ming K., E-mail: tan.ming.kwang@monash.edu [School of Engineering, Monash University Malaysia, 47500 Bandar Sunway, Selangor (Malaysia); Yeo, Leslie Y. [Micro/Nanophysics Research Laboratory, RMIT University, Melbourne, VIC 3001 (Australia); Friend, James R. [Department of Mechanical and Aerospace Engineering, University of California, San Diego, California 92093 (United States)

    2016-01-15

    We investigate the enhancement of heat transfer in the nucleate boiling regime by inducing high frequency acoustic waves (f ∼ 10{sup 6} Hz) on the heated surface. In the experiments, liquid droplets (deionized water) are dispensed directly onto a heated, vibrating substrate. At lower vibration amplitudes (ξ{sub s} ∼ 10{sup −9} m), the improved heat transfer is mainly due to the detachment of vapor bubbles from the heated surface and the induced thermal mixing. Upon increasing the vibration amplitude (ξ{sub s} ∼ 10{sup −8} m), the heat transfer becomes more substantial due to the rapid bursting of vapor bubbles happening at the liquid-air interface as a consequence of capillary waves travelling in the thin liquid film between the vapor bubble and the air. Further increases then lead to rapid atomization that continues to enhance the heat transfer. An acoustic wave displacement amplitude on the order of 10{sup −8} m with 10{sup 6} Hz order frequencies is observed to produce an improvement of up to 50% reduction in the surface temperature over the case without acoustic excitation.

  14. Telemetry-Enhancing Scripts

    Science.gov (United States)

    Maimone, Mark W.

    2009-01-01

    Scripts Providing a Cool Kit of Telemetry Enhancing Tools (SPACKLE) is a set of software tools that fill gaps in capabilities of other software used in processing downlinked data in the Mars Exploration Rovers (MER) flight and test-bed operations. SPACKLE tools have helped to accelerate the automatic processing and interpretation of MER mission data, enabling non-experts to understand and/or use MER query and data product command simulation software tools more effectively. SPACKLE has greatly accelerated some operations and provides new capabilities. The tools of SPACKLE are written, variously, in Perl or the C or C++ language. They perform a variety of search and shortcut functions that include the following: Generating text-only, Event Report-annotated, and Web-enhanced views of command sequences; Labeling integer enumerations with their symbolic meanings in text messages and engineering channels; Systematic detecting of corruption within data products; Generating text-only displays of data-product catalogs including downlink status; Validating and labeling of commands related to data products; Performing of convenient searches of detailed engineering data spanning multiple Martian solar days; Generating tables of initial conditions pertaining to engineering, health, and accountability data; Simplified construction and simulation of command sequences; and Fast time format conversions and sorting.

  15. Diablo Canyon ECCS enhancements

    International Nuclear Information System (INIS)

    Lin, A.; Lee, T.P.; Walter, L.E.

    2004-01-01

    Diablo Canyon Power Plant (DCPP) operated by Pacific Gas and Electric Co. (PG and E) is a Westinghouse designed four loop plant. In recent years, several issues were identified regarding the compliance of the Emergency Core Cooling System (ECCS) surveillance tests to the ECCS analyses assumptions. These concerns are related mostly to the High Head Safety Injection (HHSI) and the Intermediate Head Safety Injection (IHSI) systems where the injection line throttle valves are adjusted during outage surveillance testing to ensure compliance with the Technical Specifications (TS). To resolve all of the identified issues PG and E performed an ECCS reanalysis and upgraded the ECCS surveillance test program and also had Westinghouse perform a containment reanalysis using their latest model. As a result of these plant specific enhancement efforts, DCPP widened the operating window for TS surveillance testing, lowered the ECCS pumps' acceptance performance curves, and re-gained Peak Clad Temperature (PCT) and containment peak pressure margins. These enhancements are generically applicable to other plants and are addressed in this paper. (author)

  16. Acoustically enhanced heat transport

    Science.gov (United States)

    Ang, Kar M.; Yeo, Leslie Y.; Friend, James R.; Hung, Yew Mun; Tan, Ming K.

    2016-01-01

    We investigate the enhancement of heat transfer in the nucleate boiling regime by inducing high frequency acoustic waves (f ˜ 106 Hz) on the heated surface. In the experiments, liquid droplets (deionized water) are dispensed directly onto a heated, vibrating substrate. At lower vibration amplitudes (ξs ˜ 10-9 m), the improved heat transfer is mainly due to the detachment of vapor bubbles from the heated surface and the induced thermal mixing. Upon increasing the vibration amplitude (ξs ˜ 10-8 m), the heat transfer becomes more substantial due to the rapid bursting of vapor bubbles happening at the liquid-air interface as a consequence of capillary waves travelling in the thin liquid film between the vapor bubble and the air. Further increases then lead to rapid atomization that continues to enhance the heat transfer. An acoustic wave displacement amplitude on the order of 10-8 m with 106 Hz order frequencies is observed to produce an improvement of up to 50% reduction in the surface temperature over the case without acoustic excitation.

  17. Ultrasound-enhanced electrospinning.

    Science.gov (United States)

    Nieminen, Heikki J; Laidmäe, Ivo; Salmi, Ari; Rauhala, Timo; Paulin, Tor; Heinämäki, Jyrki; Hæggström, Edward

    2018-03-13

    Electrospinning is commonly used to produce polymeric nanofibers. Potential applications for such fibers include novel drug delivery systems, tissue engineering scaffolds, and filters. Electrospinning, however, has shortcomings such as needle clogging and limited ability to control the fiber-properties in a non-chemical manner. This study reports on an orifice-less technique that employs high-intensity focused ultrasound, i.e. ultrasound-enhanced electrospinning. Ultrasound bursts were used to generate a liquid protrusion with a Taylor cone from the surface of a polymer solution of polyethylene oxide. When the polymer was charged with a high negative voltage, nanofibers jetted off from the tip of the protrusion landed on an electrically grounded target held at a constant distance from the tip. Controlling the ultrasound characteristics permitted physical modification of the nanofiber topography at will without using supplemental chemical intervention. Possible applications of tailor-made fibers generated by ultrasound-enhanced electrospinning include pharmaceutical controlled-release applications and biomedical scaffolds with spatial gradients in fiber thickness and mechanical properties.

  18. Transient Enhanced Diffusion

    Science.gov (United States)

    Gossmann, Hans-Joachim L.

    1996-03-01

    Ion implantation is the standard method for dopant introduction during integrated circuit manufacturing, determining crucial device characteristics. Implantation creates point-defects, such as Si self-interstitials and vacancies, far in excess of equilibrium concentrations. Since the diffusion of common dopants involves Si point defects, the interaction of damage and dopants during subsequent annealing steps leads to the phenomenon known as "transient enhanced diffusion" (TED): The dopant diffusivities are enhanced, possibly by many orders of magnitude. The enhancement is transient since the intrinsic defects eventually diffuse into the bulk or annihilate at the surface. The desired specific dopant profile of the device is thus the result of a complex reaction, involving the creation of damage and its spatial distribution, diffusion, and interaction of the point defects among themselves and with interfaces and other defects. As device dimensions shrink and experiments become more and more expensive, the capability to predict these kinds of non-equilibrium phenomena accurately becomes crucial to Si technology development. In our experiments to extract physical mechanisms and parameters of TED we use the method of sharp B- and Sb doping spikes to track interstitial and vacancy concentrations as a function of depth during processing. Thus we gain sensitivity to small diffusion distances (low temperatures) and separate the damaged region from the region of the interaction with dopants. In addition, our method yields directly the actual point defect diffusivity. Although an ion implant initially produces Frenkel pairs, Monte-carlo simulations show that the vacancies annihilate quickly. The excess interstitials, roughly one for each implanted ion coalesce into 311defects. The subsequent evaporation of interstitials from 311ś drives TED. Si interstitial diffusion is influenced by carbon-related traps and we will demonstrate that this finding reconciles quantitatively a

  19. Biomass energy resource enhancement

    International Nuclear Information System (INIS)

    Grover, P.D.

    1995-01-01

    The demand for energy in developing countries is expected to increase to at least three times its present level within the next 25 years. If this demand is to be met by fossil fuels, an additional 2 billion tonnes of crude oil or 3 billion tonnes of coal would be needed every year. This consumption pattern, if allowed to proceed, would add 10 billion tonnes of CO 2 , to the global atmosphere each year, with its attendant risk of global warming. Therefore, just for our survival, it is imperative to progressively replace fossil fuels by biomass energy resources and to enhance the efficiency of use of the latter. Biomass is not only environmentally benign but is also abundant. It is being photosynthesised at the rate of 200 billion tonnes of carbon every year, which is equivalent to 10 times the world's present demand for energy. Presently, biomass energy resources are highly under-utilised in developing countries; when they are used it is through combustion, which is inefficient and causes widespread environmental pollution with its associated health hazards. Owing to the low bulk density and high moisture content of biomass, which make it difficult to collect, transport and store, as well as its ash-related thermochemical properties, its biodegradability and seasonal availability, the industrial use of biomass is limited to small and (some) medium-scale industries, most of which are unable to afford efficient but often costly energy conversion systems. Considering these constraints and the need to enhance the use base, biomass energy technologies appropriate to developing countries have been identified. Technologies such as briquetting and densification to upgrade biomass fuels are being adopted as conventional measures in some developing countries. The biomass energy base can be enhanced only once these technologies have been shown to be viable under local conditions and with local raw materials, after which they will multiply on their own, as has been the case

  20. Novel medical image enhancement algorithms

    Science.gov (United States)

    Agaian, Sos; McClendon, Stephen A.

    2010-01-01

    In this paper, we present two novel medical image enhancement algorithms. The first, a global image enhancement algorithm, utilizes an alpha-trimmed mean filter as its backbone to sharpen images. The second algorithm uses a cascaded unsharp masking technique to separate the high frequency components of an image in order for them to be enhanced using a modified adaptive contrast enhancement algorithm. Experimental results from enhancing electron microscopy, radiological, CT scan and MRI scan images, using the MATLAB environment, are then compared to the original images as well as other enhancement methods, such as histogram equalization and two forms of adaptive contrast enhancement. An image processing scheme for electron microscopy images of Purkinje cells will also be implemented and utilized as a comparison tool to evaluate the performance of our algorithm.

  1. Surface enhanced Raman scattering

    CERN Document Server

    Furtak, Thomas

    1982-01-01

    In the course of the development of surface science, advances have been identified with the introduction of new diagnostic probes for analytical characterization of the adsorbates and microscopic structure of surfaces and interfaces. Among the most recently de­ veloped techniques, and one around which a storm of controversy has developed, is what has now been earmarked as surface enhanced Raman scattering (SERS). Within this phenomenon, molecules adsorbed onto metal surfaces under certain conditions exhibit an anomalously large interaction cross section for the Raman effect. This makes it possible to observe the detailed vibrational signature of the adsorbate in the ambient phase with an energy resolution much higher than that which is presently available in electron energy loss spectroscopy and when the surface is in contact with a much larger amount of material than that which can be tolerated in infrared absorption experiments. The ability to perform vibrational spectroscopy under these conditions would l...

  2. Enhanced Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Jeanloz, R. [The MITRE Corporation, McLean, VA (United States); Stone, H. [The MITRE Corporation, McLean, VA (United States); et al.

    2013-12-31

    DOE, through the Geothermal Technologies Office (GTO) within the Office of Energy Efficiency and Renewable Energy, requested this study, identifying a focus on: i) assessment of technologies and approaches for subsurface imaging and characterization so as to be able to validate EGS opportunities, and ii) assessment of approaches toward creating sites for EGS, including science and engineering to enhance permeability and increase the recovery factor. Two days of briefings provided in-depth discussion of a wide range of themes and challenges in EGS, and represented perspectives from industry, government laboratories and university researchers. JASON also contacted colleagues from universities, government labs and industry in further conversations to learn the state of the field and potential technologies relevant to EGS.

  3. Surface enhanced thermo lithography

    KAUST Repository

    Coluccio, Maria Laura

    2017-01-13

    We used electroless deposition to fabricate clusters of silver nanoparticles (NPs) on a silicon substrate. These clusters are plasmonics devices that induce giant electromagnetic (EM) field increments. When those EM field are absorbed by the metal NPs clusters generate, in turn, severe temperature increases. Here, we used the laser radiation of a conventional Raman set-up to transfer geometrical patterns from a template of metal NPs clusters into a layer of thermo sensitive Polyphthalaldehyde (PPA) polymer. Temperature profile on the devices depends on specific arrangements of silver nanoparticles. In plane temperature variations may be controlled with (i) high nano-meter spatial precision and (ii) single Kelvin temperature resolution on varying the shape, size and spacing of metal nanostructures. This scheme can be used to generate strongly localized heat amplifications for applications in nanotechnology, surface enhanced thermo-lithography (SETL), biology and medicine (for space resolved cell ablation and treatment), nano-chemistry.

  4. Optically enhanced acoustophoresis

    Science.gov (United States)

    McDougall, Craig; O'Mahoney, Paul; McGuinn, Alan; Willoughby, Nicholas A.; Qiu, Yongqiang; Demore, Christine E. M.; MacDonald, Michael P.

    2017-08-01

    Regenerative medicine has the capability to revolutionise many aspects of medical care, but for it to make the step from small scale autologous treatments to larger scale allogeneic approaches, robust and scalable label free cell sorting technologies are needed as part of a cell therapy bioprocessing pipeline. In this proceedings we describe several strategies for addressing the requirements for high throughput without labeling via: dimensional scaling, rare species targeting and sorting from a stable state. These three approaches are demonstrated through a combination of optical and ultrasonic forces. By combining mostly conservative and non-conservative forces from two different modalities it is possible to reduce the influence of flow velocity on sorting efficiency, hence increasing robustness and scalability. One such approach can be termed "optically enhanced acoustophoresis" which combines the ability of acoustics to handle large volumes of analyte with the high specificity of optical sorting.

  5. Wedgelet Enhanced Appearance Models

    DEFF Research Database (Denmark)

    Darkner, Sune; Larsen, Rasmus; Stegmann, Mikkel Bille

    2004-01-01

    Statistical region-based segmentation methods such as the Active Appearance Model (AAM) are used for establishing dense correspondences in images based on learning the variation in shape and pixel intensities in a training set. For low resolution 2D images correspondences can be recovered reliably...... in real-time. However, as resolution increases this becomes infeasible due to excessive storage and computational requirements. In this paper we propose to reduce the textural components by modelling the coefficients of a wedgelet based regression tree instead of the original pixel intensities....... The wedgelet regression trees employed are based on triangular domains and estimated using cross validation. The wedgelet regression trees are functional descriptions of the intensity information and serve to 1) reduce noise and 2) produce a compact textural description. The wedgelet enhanced appearance model...

  6. Ecologically Enhancing Coastal Infrastructure

    Science.gov (United States)

    Mac Arthur, Mairi; Naylor, Larissa; Hansom, Jim; Burrows, Mike; Boyd, Ian

    2017-04-01

    Hard engineering structures continue to proliferate in the coastal zone globally in response to increasing pressures associated with rising sea levels, coastal flooding and erosion. These structures are typically plain-cast by design and function as poor ecological surrogates for natural rocky shores which are highly topographically complex and host a range of available microhabitats for intertidal species. Ecological enhancement mitigates some of these negative impacts by integrating components of nature into the construction and design of these structures to improve their sustainability, resilience and multifunctionality. In the largest UK ecological enhancement trial to date, 184 tiles (15x15cm) of up to nine potential designs were deployed on vertical concrete coastal infrastructure in 2016 at three sites across the UK (Saltcoats, Blackness and Isle of Wight). The surface texture and complexity of the tiles were varied to test the effect of settlement surface texture at the mm-cm scale of enhancement on the success of colonisation and biodiversity in the mid-upper intertidal zone in order to answer the following experimental hypotheses: • Tiles with mm-scale geomorphic complexity will have greater barnacle abundances • Tiles with cm-scale geomorphic complexity will have greater species richness than mm-scale tiles. A range of methods were used in creating the tile designs including terrestrial laser scanning of creviced rock surfaces to mimic natural rocky shore complexity as well as artificially generated complexity using computer software. The designs replicated the topographic features of high ecological importance found on natural rocky shores and promoted species recruitment and community composition on artificial surfaces; thus enabling us to evaluate biological responses to geomorphic complexity in a controlled field trial. At two of the sites, the roughest tile designs (cm scale) did not have the highest levels of barnacle recruits which were

  7. Color image and video enhancement

    CERN Document Server

    Lecca, Michela; Smolka, Bogdan

    2015-01-01

    This text covers state-of-the-art color image and video enhancement techniques. The book examines the multivariate nature of color image/video data as it pertains to contrast enhancement, color correction (equalization, harmonization, normalization, balancing, constancy, etc.), noise removal and smoothing. This book also discusses color and contrast enhancement in vision sensors and applications of image and video enhancement.   ·         Focuses on enhancement of color images/video ·         Addresses algorithms for enhancing color images and video ·         Presents coverage on super resolution, restoration, in painting, and colorization.

  8. The Enhanced Speed Bag System

    Science.gov (United States)

    2016-03-18

    July–August 2015 Army Sustainment46 The enhanced speed bag sys-tem (ESBS) is a cutting-edge piece of equipment. Its pur- pose is to facilitate...reasonable speed (20 knots). The ESBS enables Sol- diers to conduct quick and accurate resupply operations while avoiding enemy small-arms fire and...Afghanistan, from December 2014 to January 2015. ESBS Specifications The ESBS is composed of the The Enhanced Speed Bag System The enhanced speed bag

  9. Optical Enhancement of Degraded Fingerprints.

    Science.gov (United States)

    1986-05-01

    They form a general set of simple filters that can enhance various types of degraded fingerprints ( whorl , central pocket loop, tented arch, twinned...section 1). Both the degraded fingerprint and its enhancement are shown and discussed. The first degraded fingerprint , shown in Figure 4-6(a), is a whorl ...Enhancement of Degraded Fingerprints THESIS/WWATIO 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 8. CONTRACT OR GRANT NUMBER(s) Hal Erling Olimb

  10. Enhanced Micellar Catalysis LDRD.

    Energy Technology Data Exchange (ETDEWEB)

    Betty, Rita G.; Tucker, Mark D; Taggart, Gretchen; Kinnan, Mark K.; Glen, Crystal Chanea; Rivera, Danielle; Sanchez, Andres; Alam, Todd Michael

    2012-12-01

    The primary goals of the Enhanced Micellar Catalysis project were to gain an understanding of the micellar environment of DF-200, or similar liquid CBW surfactant-based decontaminants, as well as characterize the aerosolized DF-200 droplet distribution and droplet chemistry under baseline ITW rotary atomization conditions. Micellar characterization of limited surfactant solutions was performed externally through the collection and measurement of Small Angle X-Ray Scattering (SAXS) images and Cryo-Transmission Electron Microscopy (cryo-TEM) images. Micellar characterization was performed externally at the University of Minnesotas Characterization Facility Center, and at the Argonne National Laboratory Advanced Photon Source facility. A micellar diffusion study was conducted internally at Sandia to measure diffusion constants of surfactants over a concentration range, to estimate the effective micelle diameter, to determine the impact of individual components to the micellar environment in solution, and the impact of combined components to surfactant phase behavior. Aerosolized DF-200 sprays were characterized for particle size and distribution and limited chemical composition. Evaporation rates of aerosolized DF-200 sprays were estimated under a set of baseline ITW nozzle test system parameters.

  11. Enhanced sampling algorithms.

    Science.gov (United States)

    Mitsutake, Ayori; Mori, Yoshiharu; Okamoto, Yuko

    2013-01-01

    In biomolecular systems (especially all-atom models) with many degrees of freedom such as proteins and nucleic acids, there exist an astronomically large number of local-minimum-energy states. Conventional simulations in the canonical ensemble are of little use, because they tend to get trapped in states of these energy local minima. Enhanced conformational sampling techniques are thus in great demand. A simulation in generalized ensemble performs a random walk in potential energy space and can overcome this difficulty. From only one simulation run, one can obtain canonical-ensemble averages of physical quantities as functions of temperature by the single-histogram and/or multiple-histogram reweighting techniques. In this article we review uses of the generalized-ensemble algorithms in biomolecular systems. Three well-known methods, namely, multicanonical algorithm, simulated tempering, and replica-exchange method, are described first. Both Monte Carlo and molecular dynamics versions of the algorithms are given. We then present various extensions of these three generalized-ensemble algorithms. The effectiveness of the methods is tested with short peptide and protein systems.

  12. Allergens: An Enhanced Focus.

    Science.gov (United States)

    Spotz, Kristen

    2018-01-01

    Food Allergy Awareness Week was created with the purpose of placing a spotlight on the seriousness of food allergies. Recognized in the United States in mid-May every year, Food Allergy Awareness Week serves as a reminder of the over 15 million Americans who suffer from food allergies. The importance of allergies and allergen labeling can be seen when looking at U.S. Food and Drug Administration recall data: of the 764 recalls in 2016, 305 (representing more than 40%) were due to undeclared allergens. However, recalls for undeclared allergens are a complex issue with numerous factors. The implementation of prevention-based systems with the necessary management components and further error-proofing the systems, along with allergen awareness embedded throughout a company's food safety culture, can likely help reduce the number of recalls for undeclared allergens. As a resource to manufacturers, the Grocery Manufacturers Association and the Food Allergy Research and Resource Program have developed several resources to assist with developing robust allergen management programs. By reducing the number of recalls for undeclared allergens, the food industry will likely increase and maintain consumer confidence and trust of the food-allergic community. This enhanced consumer confidence and trust could eventually open the door for further collaboration with the food-allergic community and, potentially, advance allergen-related policies.

  13. Development of enhanced radioprotectors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Kyu; Chun, K. J.; Lee, Y. K.; Kim, Y. K.; Lee, B. H.; Song, H. S.; Lee, C. J.; Chung, K. M.; Shin, H. S.; Park, T. W

    2000-04-01

    Biological model systems such as TSH mutations, animals and their reproductive organs, and cultured cell lines and human peripheral lymphocytes have been set up for screening radioprotective or radiosensitizing activities of natural products. About 100 natural plants were in vivo and in vitro tested. Among them, Salvia miltiorrhiza, Areca catechu, Cornus officinalis, and portulaca oleracea showed 20 percent of radioprotective activities. On the other hand, Acanthopanax sessiliflous, Melia japonica, and Agastache rugosa revealed radiosensitizing activities. Experimental studies on the farnesyl transferase inhibitors showed the results that some of the inhibitors lead to higher levels of cell death after {gamma}-irradiation and increased radiosensitivity in H-ras-transformed NIH3T3 cells and MCF-10A human tumor cells. Molecular biochemical studies on the mechanism of radioprotection was carried out using cultured cells. The treatment of DTT increased cell survival after gamma-irradiation,decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. The result of mechanism studies will be applied to elucidate the radioprotection mechanism and to develop enhanced radioprotectors. Furthermore, our results indicate that use of antioxidants in combination can efficiently modulate the radiation-induced cell damage like apoptosis and can be applied to alleviate the cellular damage in tumor patients during radiotherapy. (author)

  14. Enhancing chemical reactions

    Science.gov (United States)

    Morrey, John R.

    1978-01-01

    Methods of enhancing selected chemical reactions. The population of a selected high vibrational energy state of a reactant molecule is increased substantially above its population at thermal equilibrium by directing onto the molecule a beam of radiant energy from a laser having a combination of frequency and intensity selected to pump the selected energy state, and the reaction is carried out with the temperature, pressure, and concentrations of reactants maintained at a combination of values selected to optimize the reaction in preference to thermal degradation by transforming the absorbed energy into translational motion. The reaction temperature is selected to optimize the reaction. Typically a laser and a frequency doubler emit radiant energy at frequencies of .nu. and 2.nu. into an optical dye within an optical cavity capable of being tuned to a wanted frequency .delta. or a parametric oscillator comprising a non-centrosymmetric crystal having two indices of refraction, to emit radiant energy at the frequencies of .nu., 2.nu., and .delta. (and, with a parametric oscillator, also at 2.nu.-.delta.). Each unwanted frequency is filtered out, and each desired frequency is focused to the desired radiation flux within a reaction chamber and is reflected repeatedly through the chamber while reactants are fed into the chamber and reaction products are removed therefrom.

  15. Development of enhanced radioprotectors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Kyu; Park, K.B.; Lee, Y.I. [and others

    1999-04-01

    Biological model systems such as TSH mutations, animals and their reproductive organs, and cultured cell lines has been set up for screening radioprotective or radiosensitizing activities of natural products. About 100 natural plants were in vivo and in vitro tested. Among them, Salvia miltiorrhiza, Areca catechu, Cornus officinalis, and Portulaca oleracea showed 20% of radioprotective activities. On the other hand, Acanthopanax sessiliflous, Melia japonica, and Agastache rugosa revealed radiosensitizing activities. Experimental studies on the farnesyltransferase inhibitors showed the results that some of the inhibits lead to higher levels of cell death after {gamma} -irradiation and increased radiosensitivity in H-ras-transformed NIH3T3 cells and MCF-10A human tumor cells. Molecular biochemical studies on the mechanism of radioprotection was carried out using cultured cells. The treatment of DTT increased cell survival after gamma-irradiation, decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. Samples shown excellent radioprotective or radiosensitizing activities will be subjected to purification to develop radioprotectants and radiosensitizers applicable to human beings. The result of mechanism studies will be applied to elucidate the radioprotection mechanism and the develop enhanced radioprotectors. (author). 145 refs., 21 tabs., 29 figs.

  16. Development of enhanced radioprotectors

    International Nuclear Information System (INIS)

    Kim, Jin Kyu; Park, K.B.; Lee, Y.I.

    1999-04-01

    Biological model systems such as TSH mutations, animals and their reproductive organs, and cultured cell lines has been set up for screening radioprotective or radiosensitizing activities of natural products. About 100 natural plants were in vivo and in vitro tested. Among them, Salvia miltiorrhiza, Areca catechu, Cornus officinalis, and Portulaca oleracea showed 20% of radioprotective activities. On the other hand, Acanthopanax sessiliflous, Melia japonica, and Agastache rugosa revealed radiosensitizing activities. Experimental studies on the farnesyltransferase inhibitors showed the results that some of the inhibits lead to higher levels of cell death after γ -irradiation and increased radiosensitivity in H-ras-transformed NIH3T3 cells and MCF-10A human tumor cells. Molecular biochemical studies on the mechanism of radioprotection was carried out using cultured cells. The treatment of DTT increased cell survival after gamma-irradiation, decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. Samples shown excellent radioprotective or radiosensitizing activities will be subjected to purification to develop radioprotectants and radiosensitizers applicable to human beings. The result of mechanism studies will be applied to elucidate the radioprotection mechanism and the develop enhanced radioprotectors. (author). 145 refs., 21 tabs., 29 figs

  17. Development of enhanced radioprotectors

    International Nuclear Information System (INIS)

    Kim, Jin Kyu; Chun, K. J.; Lee, Y. K.; Kim, Y. K.; Lee, B. H.; Song, H. S.; Lee, C. J.; Chung, K. M.; Shin, H. S.; Park, T. W.

    2000-04-01

    Biological model systems such as TSH mutations, animals and their reproductive organs, and cultured cell lines and human peripheral lymphocytes have been set up for screening radioprotective or radiosensitizing activities of natural products. About 100 natural plants were in vivo and in vitro tested. Among them, Salvia miltiorrhiza, Areca catechu, Cornus officinalis, and portulaca oleracea showed 20 percent of radioprotective activities. On the other hand, Acanthopanax sessiliflous, Melia japonica, and Agastache rugosa revealed radiosensitizing activities. Experimental studies on the farnesyl transferase inhibitors showed the results that some of the inhibitors lead to higher levels of cell death after γ-irradiation and increased radiosensitivity in H-ras-transformed NIH3T3 cells and MCF-10A human tumor cells. Molecular biochemical studies on the mechanism of radioprotection was carried out using cultured cells. The treatment of DTT increased cell survival after gamma-irradiation,decreased in the frequencies of micronucleus, and reduction in DNA fragmentation and apoptotic cells. Induction of apoptosis after irradiation was revealed by the changes in the relative cell death, increase in the relative amount of apoptotic cells, and the induction of DNA fragmentation. The result of mechanism studies will be applied to elucidate the radioprotection mechanism and to develop enhanced radioprotectors. Furthermore, our results indicate that use of antioxidants in combination can efficiently modulate the radiation-induced cell damage like apoptosis and can be applied to alleviate the cellular damage in tumor patients during radiotherapy. (author)

  18. ENHANCE: Enhancing Brain Plasticity for Sensorimotor Recovery in ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ENHANCE: Enhancing Brain Plasticity for Sensorimotor Recovery in Spastic Hemiparesis. Often, people who have had a stroke experience problems recovering the use of their arms, and the issue may persist for a long time. This research will test new ways to boost recovery using non-painful brain stimulation and ...

  19. Plasmon Enhanced Photoemission

    Energy Technology Data Exchange (ETDEWEB)

    Polyakov, Aleksandr [Univ. of California, Berkeley, CA (United States)

    2012-05-08

    this work, the structure consisted of rectangular nano-grooves (NGs) arranged in a subwavelength grating on a metal surface is presented that provides a dramatic increase in the metal’s absorption, field localization, and field enhancement. When light is polarized perpendicular to the orientation of the grooves a standing SPP wave is excited along the vertical walls in the NGs, that act as Fabry-Perot resonators. By adjusting the geometry of the NGs and the period of the subwavelength grating the resonance can be fine tuned to a desired position, for example, the laser fundamental wavelength, anywhere from the UV to the near infrared (NIR). Two types of gratings are presented: (a) a gold grating with period of 600 nm, and (b) an aluminum-gold grating with a period of 100 nm; both with resonance at 720 nm. In each case, strong on-resonance absorption was observed, with over 98% for grating (b). Unlike the grating-coupled SPP waves, where the angle is well defined by the momentum matching condition, the resonant NGs allow coupling to the standing modes at a range of angles of incidence, referred to as the angular bandwidth. A new model for the on-resonance absorption based on the ensamble action of the NGs is presented that serves as the basis for a design of an NG grating with an ultrawide spectral as well as angular bandwidth. For sample (b), the angular bandwidth is 80 degrees, corresponding to an opening angle of 160 degrees. The photoemission enhancement for such a grating was measured to be seven orders of magnitude for a four-photon photoemission. This is an incredible result demonstrating the power of the plasmonic grating presented, which is an efficient light trapper and field enhancer for a non-linear processes. These results demonstrate that the metal photocathode prepared with a NG grating on the metal surface will provide sufficient pulse charge driven by a 1 μJ 15fs pulsed laser at 800 nm for the optimum FEL operation.

  20. The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis

    International Nuclear Information System (INIS)

    Uchiyama, Tatsuki; Kawabata, Hiroshi; Miura, Yasuo; Yoshioka, Satoshi; Iwasa, Masaki; Yao, Hisayuki; Sakamoto, Soichiro; Fujimoto, Masakazu; Haga, Hironori; Kadowaki, Norimitsu; Maekawa, Taira; Takaori-Kondo, Akifumi

    2015-01-01

    Growth differentiation factor 15 (GDF15) is a pleiotropic cytokine that belongs to the transforming growth factor-β superfamily. Elevated serum concentrations of this cytokine have been reported in patients with various malignancies. To assess the potential roles of GDF15 in hematologic malignancies, we measured its serum levels in patients with these diseases. We found that serum GDF15 levels were elevated in almost all these patients, particularly in patients with primary myelofibrosis (PMF). Immunohistochemical staining of bone marrow (BM) specimens revealed that GDF15 was strongly expressed by megakaryocytes, which may be sources of increased serum GDF15 in PMF patients. Therefore, we further assessed the contribution of GDF15 to the pathogenesis of PMF. Recombinant human (rh) GDF15 enhanced the growth of human BM mesenchymal stromal cells (BM-MSCs), and it enhanced the potential of these cells to support human hematopoietic progenitor cell growth in a co-culture system. rhGDF15 enhanced the growth of human primary fibroblasts, but it did not affect their expression of profibrotic genes. rhGDF15 induced osteoblastic differentiation of BM-MSCs in vitro, and pretreatment of BM-MSCs with rGDF15 enhanced the induction of bone formation in a xenograft mouse model. These results suggest that serum levels of GDF15 in PMF are elevated, that megakaryocytes are sources of this cytokine in BM, and that GDF15 may modulate the pathogenesis of PMF by enhancing proliferation and promoting osteogenic differentiation of BM-MSCs

  1. Motif signatures of transcribed enhancers

    KAUST Repository

    Kleftogiannis, Dimitrios

    2017-09-14

    In mammalian cells, transcribed enhancers (TrEn) play important roles in the initiation of gene expression and maintenance of gene expression levels in spatiotemporal manner. One of the most challenging questions in biology today is how the genomic characteristics of enhancers relate to enhancer activities. This is particularly critical, as several recent studies have linked enhancer sequence motifs to specific functional roles. To date, only a limited number of enhancer sequence characteristics have been investigated, leaving space for exploring the enhancers genomic code in a more systematic way. To address this problem, we developed a novel computational method, TELS, aimed at identifying predictive cell type/tissue specific motif signatures. We used TELS to compile a comprehensive catalog of motif signatures for all known TrEn identified by the FANTOM5 consortium across 112 human primary cells and tissues. Our results confirm that distinct cell type/tissue specific motif signatures characterize TrEn. These signatures allow discriminating successfully a) TrEn from random controls, proxy of non-enhancer activity, and b) cell type/tissue specific TrEn from enhancers expressed and transcribed in different cell types/tissues. TELS codes and datasets are publicly available at http://www.cbrc.kaust.edu.sa/TELS.

  2. Metaheuristic applications to speech enhancement

    CERN Document Server

    Kunche, Prajna

    2016-01-01

    This book serves as a basic reference for those interested in the application of metaheuristics to speech enhancement. The major goal of the book is to explain the basic concepts of optimization methods and their use in heuristic optimization in speech enhancement to scientists, practicing engineers, and academic researchers in speech processing. The authors discuss why it has been a challenging problem for researchers to develop new enhancement algorithms that aid in the quality and intelligibility of degraded speech. They present powerful optimization methods to speech enhancement that can help to solve the noise reduction problems. Readers will be able to understand the fundamentals of speech processing as well as the optimization techniques, how the speech enhancement algorithms are implemented by utilizing optimization methods, and will be given the tools to develop new algorithms. The authors also provide a comprehensive literature survey regarding the topic.

  3. Resolution Enhancement of Multilook Imagery

    Energy Technology Data Exchange (ETDEWEB)

    Galbraith, Amy E. [Univ. of Arizona, Tucson, AZ (United States)

    2004-07-01

    This dissertation studies the feasibility of enhancing the spatial resolution of multi-look remotely-sensed imagery using an iterative resolution enhancement algorithm known as Projection Onto Convex Sets (POCS). A multi-angle satellite image modeling tool is implemented, and simulated multi-look imagery is formed to test the resolution enhancement algorithm. Experiments are done to determine the optimal con guration and number of multi-angle low-resolution images needed for a quantitative improvement in the spatial resolution of the high-resolution estimate. The important topic of aliasing is examined in the context of the POCS resolution enhancement algorithm performance. In addition, the extension of the method to multispectral sensor images is discussed and an example is shown using multispectral confocal fluorescence imaging microscope data. Finally, the remote sensing issues of atmospheric path radiance and directional reflectance variations are explored to determine their effect on the resolution enhancement performance.

  4. COMPARISON OF IMAGE ENHANCEMENT METHODS FOR CHROMOSOME KARYOTYPE IMAGE ENHANCEMENT

    Directory of Open Access Journals (Sweden)

    Dewa Made Sri Arsa

    2017-02-01

    Full Text Available The chromosome is a set of DNA structure that carry information about our life. The information can be obtained through Karyotyping. The process requires a clear image so the chromosome can be evaluate well. Preprocessing have to be done on chromosome images that is image enhancement. The process starts with image background removing. The image will be cleaned background color. The next step is image enhancement. This paper compares several methods for image enhancement. We evaluate some method in image enhancement like Histogram Equalization (HE, Contrast-limiting Adaptive Histogram Equalization (CLAHE, Histogram Equalization with 3D Block Matching (HE+BM3D, and basic image enhancement, unsharp masking. We examine and discuss the best method for enhancing chromosome image. Therefore, to evaluate the methods, the original image was manipulated by the addition of some noise and blur. Peak Signal-to-noise Ratio (PSNR and Structural Similarity Index (SSIM are used to examine method performance. The output of enhancement method will be compared with result of Professional software for karyotyping analysis named Ikaros MetasystemT M . Based on experimental results, HE+BM3D method gets a stable result on both scenario noised and blur image.

  5. Enhanced Design Alternative IV

    International Nuclear Information System (INIS)

    Kramer, N.E.

    1999-01-01

    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the Design Input Request for LADS Phase II EDA Evaluations (CRWMS M and O 1999b) and (CRWMS M and O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as line load. Continuous pre-closure ventilation keeps the waste packages from exceeding their 350 C cladding and 200 C (4.3.6) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and drip shields will be emplaced at closure to improve post-closure performance. The EDA IV concept includes more defense-in-depth layers than the VA reference design because of its backfill, drip shield, waste package shielding, and integral filler features. These features contribute to the low dose-rate to the public achieved during the first 10,000 years of repository life as shown in Figure 3. Investigation of the EDA IV concept has led to the following general conclusions: (1) The total life cycle cost for EDA IV is about $21.7 billion which equates to a $11.3 billion net present value (both figures rounded up). (2) The incidence of design basis events for EDA IV is similar to the VA reference design. (3) The emplacement of the waste packages in drifts will be similar to the VA reference design. However, heavier equipment may be required because the shielded waste package will be heavier. (4) The heavier

  6. Environmental engineering education enhancement

    Science.gov (United States)

    Caporali, E.

    2012-04-01

    Since higher education plays a central role in the development of both human beings and modern societies, enhancing social, cultural and economic development, active citizenship, ethical values and expertises for a sustainable growth, environment respectful, the European Commission promotes a wide range of programmes. Among the EC programmes, the TEMPUS - Trans European Mobility Programme for University Studies, with the support of the DG EAC of the European Commission, has contributed to many aspects of general interest for higher education. Curricula harmonization, LifeLong Learning Programme development, ICT use, quality assessment, accreditation, innovation learning methods, growth of networks of institutions trusting each other, are the focused aspects. Such a solid cooperation framework is surely among the main outcomes of the TEMPUS Projects leaded by the University of Firenze UNIFI (Italy), DEREC - Development of Environment and Resources Engineering Curriculum (2005-2008), and its spin-off DEREL - Development of Environment and Resources Engineering Learning (2010-2013), and VICES - Videoconferencing Educational Services (2009-2012). DEREC and DEREL TEMPUS projects, through the co-operation of Universities in Italy, Austria, Germany, Greece, Macedonia, Albania and Serbia, are aimed at the development of first and second level curricula in "Environment and Resources Engineering" at the Ss. Cyril and Methodius University - UKIM Skopje (MK). In the DEREC Project the conditions for offering a joint degree title in the field of Environmental Engineering between UNIFI and UKIM Skopje were fulfilled and a shared educational programme leading to the mutual recognition of degree titles was defined. The DEREL project, as logical continuation of DEREC, is aimed to introduce a new, up-to-date, postgraduate second level curriculum in Environment and Resources Engineering at UKIM Skopje, University of Novi Sad (RS) and Polytechnic University of Tirana (AL). following

  7. Excitation enhancement and extraction enhancement with photonic crystals

    Science.gov (United States)

    Shapira, Ofer; Soljacic, Marin; Zhen, Bo; Chua, Song-Liang; Lee, Jeongwon; Joannopoulos, John

    2015-03-03

    Disclosed herein is a system for stimulating emission from at least one an emitter, such as a quantum dot or organic molecule, on the surface of a photonic crystal comprising a patterned dielectric substrate. Embodiments of this system include a laser or other source that illuminates the emitter and the photonic crystal, which is characterized by an energy band structure exhibiting a Fano resonance, from a first angle so as to stimulate the emission from the emitter at a second angle. The coupling between the photonic crystal and the emitter may result in spectral and angular enhancement of the emission through excitation and extraction enhancement. These enhancement mechanisms also reduce the emitter's lasing threshold. For instance, these enhancement mechanisms enable lasing of a 100 nm thick layer of diluted organic molecules solution with reduced threshold intensity. This reduction in lasing threshold enables more efficient organic light emitting devices and more sensitive molecular sensing.

  8. Resolution enhancement techniques in microscopy

    Science.gov (United States)

    Cremer, Christoph; Masters, Barry R.

    2013-05-01

    We survey the history of resolution enhancement techniques in microscopy and their impact on current research in biomedicine. Often these techniques are labeled superresolution, or enhanced resolution microscopy, or light-optical nanoscopy. First, we introduce the development of diffraction theory in its relation to enhanced resolution; then we explore the foundations of resolution as expounded by the astronomers and the physicists and describe the conditions for which they apply. Then we elucidate Ernst Abbe's theory of optical formation in the microscope, and its experimental verification and dissemination to the world wide microscope communities. Second, we describe and compare the early techniques that can enhance the resolution of the microscope. Third, we present the historical development of various techniques that substantially enhance the optical resolution of the light microscope. These enhanced resolution techniques in their modern form constitute an active area of research with seminal applications in biology and medicine. Our historical survey of the field of resolution enhancement uncovers many examples of reinvention, rediscovery, and independent invention and development of similar proposals, concepts, techniques, and instruments. Attribution of credit is therefore confounded by the fact that for understandable reasons authors stress the achievements from their own research groups and sometimes obfuscate their contributions and the prior art of others. In some cases, attribution of credit is also made more complex by the fact that long term developments are difficult to allocate to a specific individual because of the many mutual connections often existing between sometimes fiercely competing, sometimes strongly collaborating groups. Since applications in biology and medicine have been a major driving force in the development of resolution enhancing approaches, we focus on the contribution of enhanced resolution to these fields.

  9. Speech enhancement theory and practice

    CERN Document Server

    Loizou, Philipos C

    2013-01-01

    With the proliferation of mobile devices and hearing devices, including hearing aids and cochlear implants, there is a growing and pressing need to design algorithms that can improve speech intelligibility without sacrificing quality. Responding to this need, Speech Enhancement: Theory and Practice, Second Edition introduces readers to the basic problems of speech enhancement and the various algorithms proposed to solve these problems. Updated and expanded, this second edition of the bestselling textbook broadens its scope to include evaluation measures and enhancement algorithms aimed at impr

  10. MiRNA-486 regulates angiogenic activity and survival of mesenchymal stem cells under hypoxia through modulating Akt signal

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Xue-Feng [High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining 810001 (China); Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Department of Respiration, Qinghai Provincial People' s Hospital, Xining (China); Wang, Hua; Xiao, Feng-Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Yin, Yue [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Department of Hematology, Peking University First Hospital, Beijing (China); Xu, Qin-Qin [High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining 810001 (China); Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ge, Ri-Li, E-mail: geriligao@hotmail.com [High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining 810001 (China); Wang, Li-Sheng, E-mail: wangls@bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2016-02-12

    MicroRNA-486 (miR-486) was first identified from human fetal liver cDNA library and validated as a regulator of hematopoiesis. Its roles in regulating the biological function of bone marrow-derived mesnechymal stem cells (BM-MSCs) under hypoxia have not been explored yet. In this study, we demonstrated that exposure to hypoxia upregulates miR-486 expression in BM-MSCs. Lentivirus-mediated overexpression of miR-486 resulted in increase of hepatocyte growth factor (HGF) and vascular endothelial growth factor(VEGF) in both mRNA and protein levels. MiR-486 expression also promotes proliferation and reduces apoptosis of BM-MSCs. Whereas MiR-486 knockdown downregulated the secretion of HGF and VEGF and induced apoptosis of BM-MSCs. Furthermore, PTEN-PI3K/AKT signaling was validated to be involved in changes of BM-MSC biological functions regulated by miR-486. These results suggested that MiR-486 mediated the hypoxia-induced angiogenic activity and promoted the proliferation and survival of BM-MSCs through regulating PTEN-PI3K/AKT signaling. These findings might provide a novel understanding of effective therapeutic strategy for hypoxic-ischemic diseases. - Highlights: • miR-486 is a hypoxia-induced miRNA. • miR-486 regulates the secretion of HGF and VEGF, promotes proliferation, and inhibits apoptosis of BM-MSCs. • miR-486 enhances PI3K/AKT activity signaling by targeting PTEN molecule.

  11. MiRNA-486 regulates angiogenic activity and survival of mesenchymal stem cells under hypoxia through modulating Akt signal

    International Nuclear Information System (INIS)

    Shi, Xue-Feng; Wang, Hua; Xiao, Feng-Jun; Yin, Yue; Xu, Qin-Qin; Ge, Ri-Li; Wang, Li-Sheng

    2016-01-01

    MicroRNA-486 (miR-486) was first identified from human fetal liver cDNA library and validated as a regulator of hematopoiesis. Its roles in regulating the biological function of bone marrow-derived mesnechymal stem cells (BM-MSCs) under hypoxia have not been explored yet. In this study, we demonstrated that exposure to hypoxia upregulates miR-486 expression in BM-MSCs. Lentivirus-mediated overexpression of miR-486 resulted in increase of hepatocyte growth factor (HGF) and vascular endothelial growth factor(VEGF) in both mRNA and protein levels. MiR-486 expression also promotes proliferation and reduces apoptosis of BM-MSCs. Whereas MiR-486 knockdown downregulated the secretion of HGF and VEGF and induced apoptosis of BM-MSCs. Furthermore, PTEN-PI3K/AKT signaling was validated to be involved in changes of BM-MSC biological functions regulated by miR-486. These results suggested that MiR-486 mediated the hypoxia-induced angiogenic activity and promoted the proliferation and survival of BM-MSCs through regulating PTEN-PI3K/AKT signaling. These findings might provide a novel understanding of effective therapeutic strategy for hypoxic-ischemic diseases. - Highlights: • miR-486 is a hypoxia-induced miRNA. • miR-486 regulates the secretion of HGF and VEGF, promotes proliferation, and inhibits apoptosis of BM-MSCs. • miR-486 enhances PI3K/AKT activity signaling by targeting PTEN molecule.

  12. Geothermal Permeability Enhancement - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Joe Beall; Mark Walters

    2009-06-30

    The overall objective is to apply known permeability enhancement techniques to reduce the number of wells needed and demonstrate the applicability of the techniques to other undeveloped or under-developed fields. The Enhanced Geothermal System (EGS) concept presented in this project enhances energy extraction from reduced permeability zones in the super-heated, vapor-dominated Aidlin Field of the The Geysers geothermal reservoir. Numerous geothermal reservoirs worldwide, over a wide temperature range, contain zones of low permeability which limit the development potential and the efficient recovery of heat from these reservoirs. Low permeability results from poorly connected fractures or the lack of fractures. The Enhanced Geothermal System concept presented here expands these technologies by applying and evaluating them in a systematic, integrated program.

  13. Surface-Enhanced Raman Spectroscopy

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 15; Issue 2. Surface-Enhanced Raman Spectroscopy - Recent Advancement of Raman Spectroscopy. Ujjal Kumar Sur. General Article Volume 15 Issue 2 February 2010 pp 154-164 ...

  14. NCPA Enhancement for Physical Acoustics

    National Research Council Canada - National Science Library

    Bass, Henry

    2001-01-01

    ...-rate scientists and students and carry out effective, ONR-supported research. Specific objectives of this grant are to support research and recruitment by enhancing the infrastructure in physical acoustics...

  15. Enhanced Master Station History Report

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Enhanced Master Station History Report (EMSHR) is a compiled list of basic, historical information for every station in the station history database, beginning...

  16. Modelling of reverberation enhancement systems

    OpenAIRE

    ROUCH , Jeremy; Schmich , Isabelle; Galland , Marie-Annick

    2012-01-01

    International audience; Electroacoustic enhancement systems are increasingly specified by acoustic consultants to address the requests for a multi-purpose use of performance halls. However, there is still a lack of simple models to predict the effect induced by these systems on the acoustic field. Two models are introduced to establish the impulse responses of a room equipped with a reverberation enhancement system. These models are based on passive impulse responses according to the modified...

  17. Psychopharmacological enhancement: a conceptual framework

    OpenAIRE

    Stein, Dan J

    2012-01-01

    Abstract The availability of a range of new psychotropic agents raises the possibility that these will be used for enhancement purposes (smart pills, happy pills, and pep pills). The enhancement debate soon raises questions in philosophy of medicine and psychiatry (eg, what is a disorder?), and this debate in turn raises fundament questions in philosophy of language, science, and ethics. In this paper, a naturalistic conceptual framework is proposed for addressing these issues. This framework...

  18. Multiscale based adaptive contrast enhancement

    Science.gov (United States)

    Abir, Muhammad; Islam, Fahima; Wachs, Daniel; Lee, Hyoung

    2013-02-01

    A contrast enhancement algorithm is developed for enhancing the contrast of x-ray images. The algorithm is based on Laplacian pyramid image processing technique. The image is decomposed into three frequency sub-bands- low, medium, and high. Each sub-band contains different frequency information of the image. The detail structure of the image lies on the high frequency sub-band and the overall structure lies on the low frequency sub-band. Apparently it is difficult to extract detail structure from the high frequency sub-bands. Enhancement of the detail structures is necessary in order to find out the calcifications on the mammograms, cracks on any object such as fuel plate, etc. In our proposed method contrast enhancement is achieved from high and medium frequency sub-band images by decomposing the image based on multi-scale Laplacian pyramid and enhancing contrast by suitable image processing. Standard Deviation-based Modified Adaptive contrast enhancement (SDMACE) technique is applied to enhance the low-contrast information on the sub-bands without overshooting noise. An alpha-trimmed mean filter is used in SDMACE for sharpness enhancement. After modifying all sub-band images, the final image is derived from reconstruction of the sub-band images from lower resolution level to upper resolution level including the residual image. To demonstrate the effectiveness of the algorithm an x-ray of a fuel plate and two mammograms are analyzed. Subjective evaluation is performed to evaluate the effectiveness of the algorithm. The proposed algorithm is compared with the well-known contrast limited adaptive histogram equalization (CLAHE) algorithm. Experimental results prove that the proposed algorithm offers improved contrast of the x-ray images.

  19. Field enhancement induced laser ablation

    DEFF Research Database (Denmark)

    Fiutowski, Jacek; Maibohm, Christian; Kjelstrup-Hansen, Jakob

    Sub-diffraction spatially resolved, quantitative mapping of strongly localized field intensity enhancement on gold nanostructures via laser ablation of polymer thin films is reported. Illumination using a femtosecond laser scanning microscope excites surface plasmons in the nanostructures....... The accompanying field enhancement substantially lowers the ablation threshold of the polymer film and thus creates local ablation spots and corresponding topographic modifications of the polymer film. Such modifications are quantified straightforwardly via scanning electron and atomic force microscopy. Thickness...

  20. Bose enhancement and the ridge

    Directory of Open Access Journals (Sweden)

    Tolga Altinoluk

    2015-12-01

    Full Text Available We point out that Bose enhancement in a hadronic wave function generically leads to correlations between produced particles. We show explicitly, by calculating the projectile density matrix in the Color Glass Condensate approach to high-energy hadronic collisions, that the Bose enhancement of gluons in the projectile leads to azimuthal collimation of long range rapidity correlations of the produced particles, the so-called ridge correlations.

  1. Bose enhancement and the ridge

    Energy Technology Data Exchange (ETDEWEB)

    Altinoluk, Tolga [Departamento de Física de Partículas and IGFAE, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Galicia (Spain); Armesto, Néstor, E-mail: nestor.armesto@usc.es [Departamento de Física de Partículas and IGFAE, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Galicia (Spain); Beuf, Guillaume [Department of Physics, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel); Kovner, Alex [Physics Department, University of Connecticut, 2152 Hillside Road, Storrs, CT 06269-3046 (United States); Lublinsky, Michael [Department of Physics, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel)

    2015-12-17

    We point out that Bose enhancement in a hadronic wave function generically leads to correlations between produced particles. We show explicitly, by calculating the projectile density matrix in the Color Glass Condensate approach to high-energy hadronic collisions, that the Bose enhancement of gluons in the projectile leads to azimuthal collimation of long range rapidity correlations of the produced particles, the so-called ridge correlations.

  2. Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor

    Directory of Open Access Journals (Sweden)

    Juan Bayo

    2014-01-01

    Full Text Available Hepatocellular carcinoma (HCC is the third cause of cancer-related death worldwide. Unfortunately, the incidence and mortality associated with HCC are increasing. Therefore, new therapeutic strategies are urgently needed and the use of mesenchymal stromal cells (MSCs as carrier of therapeutic genes is emerging as a promising option. Different sources of MSCs are being studied for cell therapy and bone marrow-derived cells are the most extensively explored; however, birth associated-tissues represent a very promising source. The aim of this work was to compare the in vitro and in vivo migration capacity between bone marrow MSCs (BM-MSCs and human umbilical cord perivascular cells (HUCPVCs towards HCC. We observed that HUCPVCs presented higher in vitro and in vivo migration towards factors released by HCC. The expression of autocrine motility factor (AMF receptor, genes related with the availability of the receptor on the cell surface (caveolin-1 and -2 and metalloproteinase 3, induced by the receptor activation and important for cell migration, was increased in HUCPVCs. The chemotactic response towards recombinant AMF was increased in HUCPVCs compared to BM-MSCs, and its inhibition in the conditioned medium from HCC induced higher decrease in HUCPVC migration than in BM-MSC. Our results indicate that HUCPVCs could be a useful cellular source to deliver therapeutic genes to HCC.

  3. Pharmacological cognitive enhancement in pediatrics.

    Science.gov (United States)

    Colaneri, Natalie; Sheldon, Mark; Adesman, Andrew

    2018-03-13

    Given the pervasiveness of psychotropic medication in the youth population and an increasingly competitive culture regarding educational performance, children, teenagers, and/or their parents may increasingly seek psychotropic substances in an effort to enhance a student's cognitive abilities and/or academic performance. Physicians must become aware of this very important and clinically relevant issue and work to ensure that medications remain in the hands of patients seeking wellness and not enhancement. The current article highlights findings on the pervasiveness of stimulant misuse and diversion in youth, the motivations and effects of stimulant use, health and legal consequences associated with use, and physician perceptions and preventive practices. Ethical concerns regarding pharmacological cognitive enhancement in pediatrics are also outlined - including coercion for nonusers, inequities in access, and threats to an individual's sense of self with regard to authenticity and autonomy. Pharmacological cognitive enhancement in pediatrics will become a larger, clinically relevant issue in the coming years. Physicians who care for children and adolescents must become more aware of this issue. Given the myriad health, legal, and ethical concerns, clinicians should discourage use of pharmaceuticals for enhancement purposes in the pediatric population.

  4. Enhanced sludge washing evaluation plan

    International Nuclear Information System (INIS)

    Jensen, R.D.

    1994-09-01

    The Tank Waste Remediation System (TWRS) Program mission is to store, treat, and immobilize highly radioactive Hanford Site waste (current and future tank waste and the strontium/cesium capsules) in an environmentally sound, safe, and cost-effective manner. The scope of the TWRS Waste Pretreatment Program is to treat tank waste and separate that waste into HLW and LLW fractions and provide additional treatment as required to feed LLW and HLW immobilization facilities. Enhanced sludge washing was chosen as the baseline process for separating Hanford tank waste sludge. Section 1.0 briefly discusses the purpose of the evaluation plan and provides the background that led to the choice of enhanced sludge washing as the baseline process. Section 2.0 provides a brief summary of the evaluation plan details. Section 3.0 discusses, in some detail, the technical work planned to support the evaluation of enhanced sludge washing. Section 4.0 briefly discusses the potential important of policy issues to the evaluation. Section 5.0 discusses the methodology to be used in the evaluation process. Section 6.0 summarizes the milestones that have been defined to complete the enhanced sludge washing evaluation and provides a summary schedule to evaluate the performance of enhanced sludge washing. References are identified in Section 7.0, and additional schedule and milestone information is provided in the appendices

  5. Retinex enhancement of infrared images.

    Science.gov (United States)

    Li, Ying; He, Renjie; Xu, Guizhi; Hou, Changzhi; Sun, Yunyan; Guo, Lei; Rao, Liyun; Yan, Weili

    2008-01-01

    With the ability of imaging the temperature distribution of body, infrared imaging is promising in diagnostication and prognostication of diseases. However the poor quality of the raw original infrared images prevented applications and one of the essential problems is the low contrast appearance of the imagined object. In this paper, the image enhancement technique based on the Retinex theory is studied, which is a process that automatically retrieve the visual realism to images. The algorithms, including Frackle-McCann algorithm, McCann99 algorithm, single-scale Retinex algorithm, multi-scale Retinex algorithm and multi-scale Retinex algorithm with color restoration, are experienced to the enhancement of infrared images. The entropy measurements along with the visual inspection were compared and results shown the algorithms based on Retinex theory have the ability in enhancing the infrared image. Out of the algorithms compared, MSRCR demonstrated the best performance.

  6. Contrast enhancement CT by iopamidol

    International Nuclear Information System (INIS)

    Mori, Masaki; Makita, Nobue; Yanai, Kyoko

    1984-01-01

    In order to evaluate the contrast enhancement effect and safety of iopamidol (IOP) in CT examination, IOP was compared with angiographin (AG). In the liver and abdominal aorta, peak CT values were obtained earlier and were higher in the group with AG than in the group with IOP. However, CT values in the group with IOP decreased a little more slowly than those in the group with AG. There was no significant difference in the effect on contrast enhancement between the groups. Intravenous injection of IOP caused lower degree of burning sensation than that of AG, and some of the patients with IOP did not feel burning sensation at all. Changes in clinical laboratory values were slight before and after intravenous injection of IOP. These results suggest that IOP is satisfactory in terms of safety and effect on contrast enhancement in CT examination. (Namekawa, K.)

  7. Safety enhancement in NPP Bohunice

    International Nuclear Information System (INIS)

    Lipar, M.; Mihalik, M.

    1997-01-01

    The upgrading and safety enhancement of both the Bohunice V-1 and V-2 reactors is described in detail. The total estimated cost of the gradual reconstruction of these two units during 1996 to 1999 is 180 mil. US dollars. For the 1995 to 1997 period, the actions common for both units include a quality assurance programme, a personnel training programme, installation of a multifunction simulator, implementation of symptom-oriented operation procedures, installation of diagnostic systems, of a site security system, and of a teledosimetric system. At present, the main maintenance tasks are: to carry out major repair of units, to remedy service interruptions, to enhance equipment service availability, to enhance the technical level of corrective actions at equipment. Investment into maintenance level upgrade has grown from 7.5 mil. Slovak crowns in 1994 to estimated 32 mil. in 2000. The partners of international cooperation are mentioned. (M.D.)

  8. Enhancing graduate employability for enhancing the role of higher ...

    African Journals Online (AJOL)

    ... to enhance graduate employability through curricular, co-curricular and extracurricular activities are concerned, much has not been done in all cases. In nutshell, the agenda of graduate employability has not been given adequate attention at all levels: policy, strategy, curriculum & instruction, research and development.

  9. Convection-enhanced water evaporation

    Directory of Open Access Journals (Sweden)

    B. M. Weon

    2011-03-01

    Full Text Available Water vapor is lighter than air; this can enhance water evaporation by triggering vapor convection but there is little evidence. We directly visualize evaporation of nanoliter (2 to 700 nL water droplets resting on silicon wafer in calm air using a high-resolution dual X-ray imaging method. Temporal evolutions of contact radius and contact angle reveal that evaporation rate linearly changes with surface area, indicating convective (instead of diffusive evaporation in nanoliter water droplets. This suggests that convection of water vapor would enhance water evaporation at nanoliter scales, for instance, on microdroplets or inside nanochannels.

  10. Nanoparticles for cells proliferation enhancement

    International Nuclear Information System (INIS)

    Popa, V.; Braniste, F.; Tiginyanu, I.M.; Lisii, C.; Nacu, V.

    2013-01-01

    The potential of semiconductor nanoparticles as stimulator for avian mesenchyme stem cells proliferation enhancement is demonstrated. The effect is related to nanoparticles polarization due to external ultrasound field resulting in local electrical stimulation. Our preliminary results demonstrates that the number of cells have been increased by 23 % ±2%) in cell cultures under the action of external ultrasound stimulation. Morphological analysis and viability shows no differences between the control group and the group studied. These results suggest the possibility for tissue regeneration enhancement by remote stimulation of implanted semiconductor nanoparticles. (authors)

  11. Fibroblast growth factor-4 enhances proliferation of mouse embryonic stem cells via activation of c-Jun signaling.

    Directory of Open Access Journals (Sweden)

    Sung-Ho Kook

    Full Text Available Fibroblast growth factor-4 (FGF4 is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions. However, the exact roles of FGF4 on proliferation and differentiation of embryonic stem cells (ESCs are not completely understood. Exogenous addition of FGF4 stimulated proliferation of mouse ESCs (mESCs, as proven by the increases in DNA synthesis and cell cycle regulatory protein induction. These increases were almost completely inhibited by pre-treating cells with anti-FGF4 antibody. FGF4 also activated c-Jun N-terminal kinase (JNK and extracellular-signal regulated kinase (ERK signaling, but not p38 kinase. Blockage of JNK signaling by SP600125 or by transfection with its specific siRNA significantly inhibited FGF4-stimulated cell proliferation through the suppression of c-Jun induction and activator protein-1 (AP-1 activity. However, ERK or p38 kinase inhibitor did not affect FGF4-stimulated proliferation in mESCs. FGF4 suppressed osteogenic differentiation of mESCs by inhibiting expression of transcription factors involved in bone formation. Further, exogenous FGF4 addition stimulated proliferation of human periodontal ligament stem cells (hPDLSCs and bone marrow mesenchymal stem cells (BMMSCs via activation of ERK signaling. FGF4 also augmented mineralization of hPDLSCs, but not of BMMSCs. Collectively, it is suggested that FGF4 triggers proliferation of stem cells by activating MAPK-mediated signaling, while it affects differently osteogenic differentiation according to the origins of stem cells.

  12. Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    Shoichiro Kokabu

    2016-01-01

    Full Text Available Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between adipogenesis and osteoblastogenesis in BMMSCs wherein adipogenesis is increased relative to osteoblastogenesis are associated with decreased bone quality and quantity. Several proteins have been reported to regulate this reciprocal relationship but the exact nature of the signals regulating the balance between osteoblast and adipocyte formation within the bone marrow space remains to be determined. In this review, we focus on the role of Transducin-Like Enhancer of Split 3 (TLE3, which was recently reported to regulate the balance between osteoblast and adipocyte formation from BMMSCs. We also discuss evidence implicating canonical Wnt signalling, which plays important roles in both adipogenesis and osteoblastogenesis, in regulating TLE3 expression. Currently, there is demand for new effective therapies that target the stimulation of osteoblast differentiation to enhance bone formation. We speculate that reducing TLE3 expression or activity in BMMSCs could be a useful approach towards increasing osteoblast numbers and reducing adipogenesis in the bone marrow environment.

  13. Enhancements to PVM's BEOLIN architecture

    Science.gov (United States)

    Springer, Paul L.

    2005-01-01

    .4.3 of PVM had previously been enhanced by the addition of a new architecture, BEOLIN, which allowed a PVM user to abstract a Beowulf class computer with a private network to appear as a single system, visible to the outside world, which could spawn tasks on different internal nodes.

  14. Surface-Enhanced Raman Spectroscopy

    Indian Academy of Sciences (India)

    IAS Admin

    In Raman spectroscopy, inelastic scattering of photons from an atom or molecule in chemical entities is utilized to analyze the composition of solids, liquids and gases. However, the low cross-section limits its applications. The introduction of sur- face-enhanced Raman spectroscopy in 1974 has attracted a lot of attention ...

  15. Proceedings Technology Enhanced Assessment conference

    NARCIS (Netherlands)

    Joosten-ten Brinke, Desirée; Laanpere, Mart

    2018-01-01

    This book constitutes the proceedings of the 19th International Conference on Technology Enhanced Assessment, TEA 2016, held in Tallinn, Estonia, in October 2016. The 16 full papers presented were carefully selected from 38 submissions. They are centered around topics like measurement of higher

  16. Who Benefits from Pension Enhancements?

    Science.gov (United States)

    Koedel, Cory; Ni, Shawn; Podgursky, Michael

    2014-01-01

    During the late 1990s public pension funds across the United States accrued large actuarial surpluses. The seemingly flush conditions of the pension funds led legislators in most states to substantially improve retirement benefits for public workers, including teachers. In this study we examine the benefit enhancements to the teacher pension…

  17. Bibliometric-enhanced information retrieval

    NARCIS (Netherlands)

    Mayr, Philipp; Scharnhorst, Andrea; Larsen, Birger; Schaer, Philipp; Mutschke, Peter

    2014-01-01

    Bibliometric techniques are not yet widely used to enhance retrieval processes in digital libraries, although they offer value-added effects for users. In this workshop we will explore how statistical modelling of scholarship, such as Bradfordizing or network analysis of coauthorship network, can

  18. SUPRA - Enhanced upset recovery simulation

    NARCIS (Netherlands)

    Groen, E.; Ledegang, W.; Field, J.; Smaili, H.; Roza, M.; Fucke, L.; Nooij, S.; Goman, M.; Mayrhofer, M.; Zaichik, L.E.; Grigoryev, M.; Biryukov, V.

    2012-01-01

    The SUPRA research project - Simulation of Upset Recovery in Aviation - has been funded by the European Union 7th Framework Program to enhance the flight simulation envelope for upset recovery simulation. Within the project an extended aerodynamic model, capturing the key aerodynamics during and

  19. Bubble chamber: colour enhanced tracks

    CERN Document Server

    1998-01-01

    This artistically-enhanced image of real particle tracks was produced in the Big European Bubble Chamber (BEBC). Liquid hydrogen is used to create bubbles along the paths of the particles as a piston expands the medium. A magnetic field is produced in the detector causing the particles to travel in spirals, allowing charge and momentum to be measured.

  20. Advances in heat transfer enhancement

    CERN Document Server

    Saha, Sujoy Kumar; Sundén, Bengt; Wu, Zan

    2016-01-01

    This Brief addresses the phenomena of heat transfer enhancement. A companion edition in the SpringerBrief Subseries on Thermal Engineering and Applied Science to three other monographs including “Critical Heat Flux in Flow Boiling in Microchannels,” this volume is idea for professionals, researchers, and graduate students concerned with electronic cooling.

  1. Enhancing Author's Voice through Scripting

    Science.gov (United States)

    Young, Chase J.; Rasinski, Timothy V.

    2011-01-01

    The authors suggest using scripting as a strategy to mentor and enhance author's voice in writing. Through gradual release, students use authentic literature as a model for writing with voice. The authors also propose possible extensions for independent practice, integration across content areas, and tips for evaluation.

  2. Enhancing hydrogen spillover and storage

    Science.gov (United States)

    Yang, Ralph T [Ann Arbor, MI; Li, Yingwel [Ann Arbor, MI; Lachawiec, Jr., Anthony J.

    2011-05-31

    Methods for enhancing hydrogen spillover and storage are disclosed. One embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the hydrogen receptor to ultrasonification as doping occurs. Another embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the doped hydrogen receptor to a plasma treatment.

  3. Enhancing the Productivity of Learning.

    Science.gov (United States)

    Johnstone, D. Bruce

    1995-01-01

    It is argued that colleges and universities can become more productive by enhancing the efficiency of student learning. This requires both acceleration of learning through individually paced mastery learning, better academic focus, year-round schooling, and an earlier start to graduate and professional education. Eight strategies for enhancing…

  4. Engage, Enhance, and Extend Learning!

    Science.gov (United States)

    Keren-Kolb, Liz

    2013-01-01

    Educators often say that technology is more than a gimmick or add-on, and that it should engage, enhance, or extend learning in ways that traditional tools do not. Yet they seldom stop to define these terms, and they can be confusing, especially for teachers and preservice teachers. Recently, while collaborating on an English language arts and…

  5. Enhancing Tumor Penetration of Nanomedicines

    NARCIS (Netherlands)

    Sun, Qingxue; Ojha, Tarun; Kiessling, Fabian; Lammers, Twan; Shi, Yang

    2017-01-01

    Tumor-targeted nanomedicines have been extensively applied to alter the drawbacks and enhance the efficacy of chemotherapeutics. Despite the large number of preclinical nanomedicine studies showing initial success, their therapeutic benefit in the clinic has been rather modest, which is partially

  6. Commercialization of vein contrast enhancement

    Science.gov (United States)

    Lovhoiden, Gunnar; Deshmukh, Harshal; Vrancken, Carlos; Zhang, Yong; Zeman, Herbert D.; Weinberg, Devin

    2003-07-01

    An ongoing clinical study of an experimental infrared (IR) device, the Vein Contrast Enhancer (VCE) that visualizes surface veins for medical access, indicates that a commercial device with the performance of the existing VCE would have significant clinical utility for even a very skilled phlebotomist. A proof-of-principle prototype VCE device has now been designed and constructed that captures IR images of surface veins with a commercial CCD camera, transfers the images to a PC for real-time software image processing to enhance the vein contrast, and projects the enhanced images back onto the skin with a modified commercial LCD projector. The camera and projector are mounted on precision slides allowing for precise mechanical alignment of the two optical axes and for measuring the effects of axes misalignment. Precision alignment of the captured and projected images over the entire field-of-view is accomplished electronically by software adjustments of the translation, scaling, and rotation of the enhanced images before they are projected back onto the skin. This proof-of-principle prototype will be clinically tested and the experience gained will lead to the development of a commercial device, OnTarget!, that is compact, easy to use, and will visualize accessible veins in almost all subjects needing venipuncture.

  7. Cognitive enhancement: a brief overview

    African Journals Online (AJOL)

    healthy people seeking greater productivity. Yet the concept of drug-induced cognitive enhancement is not new. Traditionally, people trying to stay awake and focused in order to manage ... non-licensed purposes to improve academic, work and sporting performance has raised medical, ethical and regulatory issues.

  8. Motivation Enhancement Through Work Redesign.

    Science.gov (United States)

    Oldham, Greg R., Kulik, Carol T.

    1983-01-01

    The possibility of redesigning the work experiences of faculty members in an effort to enhance their motivation, productivity, and personal and work satisfactions is examined. One approach to work redesign, job characteristics theory, is described. Several strategies are discussed. (Author/MLW)

  9. Dimensional enhancement of kinetic energies

    DEFF Research Database (Denmark)

    Schleich, W.P.; Dahl, Jens Peder

    2002-01-01

    Simple thermodynamics considers kinetic energy to be an extensive variable which is proportional to the number N of particles. We present a quantum state of N noninteracting particles for which the kinetic energy increases quadratically with N. This enhancement effect is tied to the quantum...

  10. Innovative Solution to Video Enhancement

    Science.gov (United States)

    2001-01-01

    Through a licensing agreement, Intergraph Government Solutions adapted a technology originally developed at NASA's Marshall Space Flight Center for enhanced video imaging by developing its Video Analyst(TM) System. Marshall's scientists developed the Video Image Stabilization and Registration (VISAR) technology to help FBI agents analyze video footage of the deadly 1996 Olympic Summer Games bombing in Atlanta, Georgia. VISAR technology enhanced nighttime videotapes made with hand-held camcorders, revealing important details about the explosion. Intergraph's Video Analyst System is a simple, effective, and affordable tool for video enhancement and analysis. The benefits associated with the Video Analyst System include support of full-resolution digital video, frame-by-frame analysis, and the ability to store analog video in digital format. Up to 12 hours of digital video can be stored and maintained for reliable footage analysis. The system also includes state-of-the-art features such as stabilization, image enhancement, and convolution to help improve the visibility of subjects in the video without altering underlying footage. Adaptable to many uses, Intergraph#s Video Analyst System meets the stringent demands of the law enforcement industry in the areas of surveillance, crime scene footage, sting operations, and dash-mounted video cameras.

  11. Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Shinya [Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago (Japan); Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Kido, Aki, E-mail: akikido@kuhp.kyoto-u.ac.jp [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Baba, Tsukasa [Departments of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Fujimoto, Koji; Daido, Sayaka [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Matsumura, Noriomi; Konishi, Ikuo [Departments of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Togashi, Kaori [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

    2015-04-15

    Highlights: •We have assessed the peritumoral enhancement (PTE), which mimics SEE on DCE. •We evaluated the diagnostic accuracy of SEE for the myometrial invasion and the frequency of PTE. •We assessed the relationship between these enhancements and important pathologic factors. •PTE Type 1 is the main factor causing the overestimation of myometrial invasion using SEE on DCE. •PTE Type 2 correlates the myometrial invasion and may play an important role in the diagnosis of LVSI. -- Abstract: Objectives: To evaluate the diagnostic accuracy of subendometrial enhancement (SEE) in assessing the myometrial invasion in endometrial cancer, the frequency and clinical significance of peritumoral enhancement (PTE) on dynamic contrast enhanced (DCE) imaging. Materials and methods: MR images of 147 patients with endometrial cancer were retrospectively analyzed for intact SEE and PTEs: Type 1, a focal early enhancement peritumorally, and Type 2, an irregular thin-layered early intense enhancement peritumorally. Two radiologists independently assessed intact SEE and PTEs on DCE imaging and compared the lesions by the presence and depth of myometrial invasion, grade, lymphovascular space involvement (LVSI), and lymph node metastasis. The relationship between SEE, PTEs, and each factor was analyzed using univariate and multivariate analyses. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated for SEE. Results: The sensitivity, specificity, PPV, NPV and diagnostic accuracy for myometrial invasion based on SEE disruption on DCE were 96.6%, 32.1–46.4%, 85.8–88.5%, 69.2–76.5%, and 84.4–87.1%. According to multivariate analysis, SEE significantly predicted myometrial invasion (p < 0.0001). PTE Type 2 significantly predicted myometrial invasion presence (p < 0.05) and depth (p < 0.01). Conclusion: Diagnosis of myometrial invasion only by using SEE might be difficult on DCE-MRI due to the

  12. Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging

    International Nuclear Information System (INIS)

    Fujii, Shinya; Kido, Aki; Baba, Tsukasa; Fujimoto, Koji; Daido, Sayaka; Matsumura, Noriomi; Konishi, Ikuo; Togashi, Kaori

    2015-01-01

    Highlights: •We have assessed the peritumoral enhancement (PTE), which mimics SEE on DCE. •We evaluated the diagnostic accuracy of SEE for the myometrial invasion and the frequency of PTE. •We assessed the relationship between these enhancements and important pathologic factors. •PTE Type 1 is the main factor causing the overestimation of myometrial invasion using SEE on DCE. •PTE Type 2 correlates the myometrial invasion and may play an important role in the diagnosis of LVSI. -- Abstract: Objectives: To evaluate the diagnostic accuracy of subendometrial enhancement (SEE) in assessing the myometrial invasion in endometrial cancer, the frequency and clinical significance of peritumoral enhancement (PTE) on dynamic contrast enhanced (DCE) imaging. Materials and methods: MR images of 147 patients with endometrial cancer were retrospectively analyzed for intact SEE and PTEs: Type 1, a focal early enhancement peritumorally, and Type 2, an irregular thin-layered early intense enhancement peritumorally. Two radiologists independently assessed intact SEE and PTEs on DCE imaging and compared the lesions by the presence and depth of myometrial invasion, grade, lymphovascular space involvement (LVSI), and lymph node metastasis. The relationship between SEE, PTEs, and each factor was analyzed using univariate and multivariate analyses. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated for SEE. Results: The sensitivity, specificity, PPV, NPV and diagnostic accuracy for myometrial invasion based on SEE disruption on DCE were 96.6%, 32.1–46.4%, 85.8–88.5%, 69.2–76.5%, and 84.4–87.1%. According to multivariate analysis, SEE significantly predicted myometrial invasion (p < 0.0001). PTE Type 2 significantly predicted myometrial invasion presence (p < 0.05) and depth (p < 0.01). Conclusion: Diagnosis of myometrial invasion only by using SEE might be difficult on DCE-MRI due to the

  13. Enhanced Jumping-Droplet Departure.

    Science.gov (United States)

    Kim, Moon-Kyung; Cha, Hyeongyun; Birbarah, Patrick; Chavan, Shreyas; Zhong, Chen; Xu, Yuehan; Miljkovic, Nenad

    2015-12-15

    Water vapor condensation on superhydrophobic surfaces has received much attention in recent years because of its ability to shed water droplets at length scales 3 decades smaller than the capillary length (∼1 mm) via coalescence-induced droplet jumping. Jumping-droplet condensation has been demonstrated to enhance heat transfer, anti-icing, and self-cleaning efficiency and is governed by the theoretical inertial-capillary scaled jumping speed (U). When two droplets coalesce, the experimentally measured jumping speed (Uexp) is fundamentally limited by the internal fluid dynamics during the coalescence process (Uexp 2) coalescence as an avenue to break the two-droplet speed limit. Using side-view and top-view high-speed imaging to study more than 1000 jumping events on a copper oxide nanostructured superhydrophobic surface, we verify that droplet jumping occurs as a result of three fundamentally different mechanisms: (1) coalescence between two droplets, (2) coalescence among more than two droplets (multidroplet), and (3) coalescence between one or more droplets on the surface and a returning droplet that has already departed (multihop). We measured droplet-jumping speeds for a wide range of droplet radii (5-50 μm) and demonstrated that while the two-droplet capillary-to-inertial energy conversion mechanism is not identical to that of multidroplet jumping, speeds above the theoretical two-droplet limit (>0.23U) can be achieved. However, we discovered that multihop coalescence resulted in drastically reduced jumping speeds (≪0.23U) due to adverse momentum contributions from returning droplets. To quantify the impact of enhanced jumping speed on heat-transfer performance, we developed a condensation critical heat flux model to show that modest jumping speed enhancements of 50% using multidroplet jumping can enhance performance by up to 40%. Our results provide a starting point for the design of enhanced-performance jumping-droplet surfaces for industrial

  14. Enhancing who? Enhancing what? Ethics, bioethics, and transhumanism.

    Science.gov (United States)

    Koch, Tom

    2010-12-01

    Transhumanists advance a "posthuman" condition in which technological and genetic enhancements will transform humankind. They are joined in this goal by bioethicists arguing for genetic selection as a means of "enhancing evolution," improving if not also the species then at least the potential lives of future individuals. The argument of both, this paper argues, is a new riff on the old eugenics tune. As ever, it is done in the name of science and its presumed knowledge base. As ever, the result is destructive rather than instructive, bad faith promoted as high ideal. The paper concludes with the argument that species advancement is possible but in a manner thoroughly distinct from that advanced by either of these groups.

  15. Contrast enhanced CT of spinal cord angioma

    International Nuclear Information System (INIS)

    Nakamura, Takahiko; Ebitani, Tsutomu; Honma, Takao; Sofue, Muroto; Nakamura, Shigeru

    1982-01-01

    Contrast enhanced CT on 6 patients with spinal cord angioma showed enhancement in 2 of them. The conditions to produce contrast enhancement were the window width of 100 - 200, and the window level of 0 - 50. In spinal cord angioma, contrast enhanced CT is presently only an adjunct to angiography and myelography. Nevertheless, contrast enhanced CT is useful in the screening test for spinal cord angioma, in the patients who are nonindicated to angiography, and in the postoperative follow-up. (Ueda, J.)

  16. Enhanced nonlinear frequency conversion and Purcell enhancement at exceptional points

    Science.gov (United States)

    Pick, Adi; Lin, Zin; Jin, Weiliang; Rodriguez, Alejandro W.

    2017-12-01

    Exceptional points (EPs) were recently predicted to modify the spontaneous emission rate or Purcell factor of narrow-band emitters embedded in resonant cavities. We demonstrate that EPs can have an even greater impact on nonlinear optical processes like frequency conversion by deriving a general formula quantifying radiative emission from a subwavelength emitter in the vicinity of a triply resonant χ(2 ) cavity that supports an EP near the emission frequency and a bright mode at the second harmonic. We show that the resulting frequency up-conversion process can be enhanced by up to two orders of magnitude compared to nondegenerate scenarios and that, in contrast to the recently predicted spontaneous-emission enhancements, nonlinear EP enhancements can persist even when considering spatial distributions of broadband emitters, provided that the cavity satisfies special nonlinear selection rules. This is demonstrated via a two-dimensional proof-of-concept PhC designed to partially fulfill the various criteria needed to approach the derived bounds on the maximum achievable up-conversion efficiencies. Our predictions suggest an indirect but practically relevant route to experimentally observe the impact of EPs on spontaneous emission, with implications to quantum information science.

  17. Enhancement pattern of hilar cholangiocarcinoma: Contrast-enhanced ultrasound versus contrast-enhanced computed tomography

    International Nuclear Information System (INIS)

    Xu Huixiong; Chen Lida; Xie Xiaoyan; Xie Xiaohua; Xu Zuofeng; Liu Guangjian; Lin Manxia; Wang Zhu; Lu Mingde

    2010-01-01

    Objective: To compare the enhancement pattern of hilar cholangiocarcinoma on contrast-enhanced ultrasound (CEUS) with that on contrast-enhanced computed tomography (CECT). Methods: Thirty-two consecutive patients with pathologically proven hilar cholangiocarcinomas were evaluated by both low mechanical index CEUS and CECT. The enhancement feature of the tumor, portal vein infiltration, and lesion conspicuity on them was investigated. Results: In the arterial phase, the numbers of the lesions showing hyperenhancement, isoenhancement, and hypoenhancement, were 14 (43.8%), 14 (43.8%), and 4 (12.6%), on CEUS, and 12 (37.5%), 9 (28.1%), and 11 (34.4%), on CECT (P = 0.162). In portal phase, the numbers of the lesions showing hypoenhancement, isoenhancement, and hyperenhancement were 30 (93.8%), 1 (3.1%), and 1 (3.1%), on CEUS, and 23 (71.9%), 8 (25.0%), and 1 (3.1%), on CECT (P = 0.046). The detection rates for portal vein infiltration were 84.2% (16/19) for baseline ultrasound, 89.5% (17/19) for CEUS, and 78.9% (15/19) for CECT (all P > 0.05 between every two groups). CEUS significantly improved the lesion conspicuity in comparison with CECT. CEUS and CECT made correct diagnoses in 30 (93.8%) and 25 (78.1%) lesions prior to pathological examination (P = 0.125). Conclusion: The enhancement pattern of hilar cholangiocarcinoma on CEUS was similar with that on CECT in arterial phase, whereas in portal phase hilar cholangiocarcinoma shows hypoenhancement more likely on CEUS. CEUS and CECT lead to similar results in evaluating portal vein infiltration and diagnosis of this entity.

  18. Gestures Enhance Foreign Language Learning

    Directory of Open Access Journals (Sweden)

    Manuela Macedonia

    2012-11-01

    Full Text Available Language and gesture are highly interdependent systems that reciprocally influence each other. For example, performing a gesture when learning a word or a phrase enhances its retrieval compared to pure verbal learning. Although the enhancing effects of co-speech gestures on memory are known to be robust, the underlying neural mechanisms are still unclear. Here, we summarize the results of behavioral and neuroscientific studies. They indicate that the neural representation of words consists of complex multimodal networks connecting perception and motor acts that occur during learning. In this context, gestures can reinforce the sensorimotor representation of a word or a phrase, making it resistant to decay. Also, gestures can favor embodiment of abstract words by creating it from scratch. Thus, we propose the use of gesture as a facilitating educational tool that integrates body and mind.

  19. Biosurfactant-enhanced soil bioremediation

    Energy Technology Data Exchange (ETDEWEB)

    Kosaric, N.; Lu, G.; Velikonja, J. [Univ. of Western Ontario, London, Ontario (Canada)

    1995-12-01

    Bioremediation of soil contaminated with organic chemicals is a viable alternative method for clean-up and remedy of hazardous waste sites. The final objective in this approach is to convert the parent toxicant into a readily biodegradable product which is harmless to human health and/or the environment. Biodegradation of hydrocarbons in soil can also efficiently be enhanced by addition or in-situ production of biosufactants. It was generally observed that the degradation time was shortened and particularly the adaptation time for the microbes. More data from our laboratories showed that chlorinated aromatic compounds, such as 2,4-dichlorophenol, a herbicide Metolachlor, as well as naphthalene are degraded faster and more completely when selected biosurfactants are added to the soil. More recent data demonstrated an enhanced biodegradation of heavy hydrocarbons in petrochemical sludges, and in contaminated oil when biosurfactants were present or were added prior to the biodegradation process.

  20. Hereditary syndromes with enhanced radiosensitivity

    International Nuclear Information System (INIS)

    Lohmann, D.

    2000-01-01

    Sensitivity to ionizing radiation is modified by heritable genetic factors. This is exemplified by heritable disorders that are characterized by predisposition to the development of neoplasms. Cells derived from patients with ataxia telangiectasia, Nijmegen breakage syndrome and ataxia telangiektasia-like disorder show a markedly changed reaction to exposure to ionizing radiation. Correspondingly, at least in patients with ataxia telangiectasia, an enhanced radiosensitivity that is of clinical importance has been observed. In addition to these recessive disorders, some autosomal dominant cancer predisposition syndromes are associated with increased radiosensitivity. As cells from these patients still have a normal allele (that is dominant over the mutant allele), the cellular phenotype is most often normal. Specifically, there is no overtly altered reaction in response to ionizing radiation. Nevertheless, two dominant cancer predisposition syndromes, namely hereditary retinoblastoma and naevoid basal cell carcinoma syndrome, are associated with a enhanced radiosensitivity as indicated by increased development of tumors following radiation therapy. (orig.) [de

  1. Enhancing aquifer cleanup with reinjection

    International Nuclear Information System (INIS)

    Isherwood, W.F.; Ziagos, J.; Rice, D. Jr.; Krauter, P.; Nichols, E.

    1992-09-01

    Injection of water or steam, with or without chemical surfactants, is a common petroleum industry technique to enhance product recovery. In the geothermal industry, reinjection (reinjection is used to mean the injection of ground water that was previously injected) of heat- depleted subsurface fluids is commonly used to maintain reservoir pressure, thus prolonging field productivity. The use reinjection in ground-water remediation projects allows for the application of both traditional production field management and a variety of additional enhancements to the cleanup process. Development of the ideas in this paper was stimulated by an initial suggestion by Dr. Jacob Bear (personal discussions, 1990--1991) that reinjected water might be heated to aid the desorption process

  2. Equipment improvements for performance enhancement

    International Nuclear Information System (INIS)

    Gaestel, P.; Guesnon, H.; Sauze, G.

    1994-01-01

    In order to enhance the reactor availability, several improvements on reactor equipment have been developed: design optimization for stator maintenance replacement in the main alternator; adjustment modification of stator coils in the main alternator for an easier maintenance; improvement of the fuel handling line (pole crane, transfer equipment, loading machine); development of a loose part trapping system in the steam generator secondary circuit. 1 tab

  3. Photodetector with enhanced light absorption

    Science.gov (United States)

    Kane, James

    1985-01-01

    A photodetector including a light transmissive electrically conducting layer having a textured surface with a semiconductor body thereon. This layer traps incident light thereby enhancing the absorption of light by the semiconductor body. A photodetector comprising a textured light transmissive electrically conducting layer of SnO.sub.2 and a body of hydrogenated amorphous silicon has a conversion efficiency about fifty percent greater than that of comparative cells. The invention also includes a method of fabricating the photodetector of the invention.

  4. Enhanced photochemistry on metal surfaces

    International Nuclear Information System (INIS)

    Goncher, G.M.; Parsons, C.A.; Harris, C.B.

    1984-01-01

    Due to the fast relaxation of molecular excited states in the vicinity of a metal or semiconductor surface, few observations of surface photochemistry have been reported. The following work concerns the surface-enhanced photo-reactions of a variety of physisorbed molecules on roughened Ag surfaces. In summary, photodecomposition leads to a graphitic surface carbon product which is monitored via surface-enhanced Raman scattering. In most cases an initial two-photon molecular absorption step followed by further absorption and fragmentation is thought to occur. Enhancement of the incident fields occurs through roughness-mediated surface plasmon resonances. This mechanism provides the amplified electromagnetic surface fields responsible for the observed photodecomposition. The photodecomposition experiments are performed under ultra-high vacuum. Surface characterization of the roughened surfaces was done by Scanning Electron Microscopy (SEM), and electron-stimulated emission. The SEM revealed morphology on the order of 300-400 A. This size of roughness feature, when modelled as isolated spheres should exhibit the well-known Mie resonances for light of the correct wavelengths. For protrusions existing on a surface these Mie resonances can be thought of as a coupling of the light with the surface plasmon. Experimental verification of these resonances was provided by the electron-stimulated light emission results. These showed that a polished Ag surface emitted only the expected transition radiation at the frequency of the Ag bulk plasmon. Upon roughening, however, a broad range of lower frequencies extending well into the visible are seen from electron irradiation of the surface. Large enhancements are expected for those frequencies which are able to couple into the surface modes

  5. Technology Education Professional Enhancement Project

    Science.gov (United States)

    Hughes, Thomas A., Jr.

    1996-01-01

    The two goals of this project are: the use of integrative field of aerospace technology to enhance the content and instruction delivered by math, science, and technology teachers through the development of a new publication entitled NASA Technology Today, and to develop a rationale and structure for the study of technology, which establishes the foundation for developing technology education standards and programs of the future.

  6. Convection-enhanced water evaporation

    OpenAIRE

    B. M. Weon; J. H. Je; C. Poulard

    2011-01-01

    Water vapor is lighter than air; this can enhance water evaporation by triggering vapor convection but there is little evidence. We directly visualize evaporation of nanoliter (2 to 700 nL) water droplets resting on silicon wafer in calm air using a high-resolution dual X-ray imaging method. Temporal evolutions of contact radius and contact angle reveal that evaporation rate linearly changes with surface area, indicating convective (instead of diffusive) evaporation in nanoliter water droplet...

  7. Plasmonics Enhanced Smartphone Fluorescence Microscopy

    KAUST Repository

    Wei, Qingshan

    2017-05-12

    Smartphone fluorescence microscopy has various applications in point-of-care (POC) testing and diagnostics, ranging from e.g., quantification of immunoassays, detection of microorganisms, to sensing of viruses. An important need in smartphone-based microscopy and sensing techniques is to improve the detection sensitivity to enable quantification of extremely low concentrations of target molecules. Here, we demonstrate a general strategy to enhance the detection sensitivity of a smartphone-based fluorescence microscope by using surface-enhanced fluorescence (SEF) created by a thin metal-film. In this plasmonic design, the samples are placed on a silver-coated glass slide with a thin spacer, and excited by a laser-diode from the backside through a glass hemisphere, generating surface plasmon polaritons. We optimized this mobile SEF system by tuning the metal-film thickness, spacer distance, excitation angle and polarization, and achieved ~10-fold enhancement in fluorescence intensity compared to a bare glass substrate, which enabled us to image single fluorescent particles as small as 50 nm in diameter and single quantum-dots. Furthermore, we quantified the detection limit of this platform by using DNA origami-based brightness standards, demonstrating that ~80 fluorophores per diffraction-limited spot can be readily detected by our mobile microscope, which opens up new opportunities for POC diagnostics and sensing applications in resource-limited-settings.

  8. Contrast-enhanced digital mammography

    Energy Technology Data Exchange (ETDEWEB)

    Dromain, Clarisse [Department of Radiology, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France)], E-mail: dromain@igr.fr; Balleyguier, Corinne; Adler, Ghazal [Department of Radiology, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France); Garbay, Jean Remi [Department of Surgery, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France); Delaloge, Suzette [Department of Medicine, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex (France)

    2009-01-15

    CEDM is a recent development of digital mammography using the intra-venous injection of an iodinated contrast agent in conjunction with a mammography examination. Two techniques have been developed to perform CEDM examinations: the temporal subtraction technique with acquisition of high-energy images before and after contrast medium injection and the dual energy technique with acquisition of a pair of low and high-energy images only after contrast medium injection. The temporal subtraction technique offered the possibility to analyze the kinetic curve of enhancement of breast lesions, similarly to breast MRI. The dual energy technique do not provide information about the kinetic of tumor enhancement but allows the acquisition of multiples views of the same breast or bilateral examination and is less sensitive to patient motion than temporal CEDM. Initial clinical experience has shown the ability of CEDM to map the distribution of neovasculature induced by cancer using mammography. Moreover, previous studies have shown a superiority of MX + CEDM, either for the assessment of the probability of malignancy than for BIRADS assessment comparing to MX alone. The potential clinical applications are the clarification of mammographically equivocal lesions, the detection of occult lesions on standard mammography, particularly in dense breast, the determination of the extent of disease, the assessment of recurrent disease and the monitoring of the response to chemotherapy. CEDM should result in a simple way to enhance the detection and the characterization of breast lesions.

  9. BNFL Magnox - Upgrades and enhancements

    International Nuclear Information System (INIS)

    Udbinac, M.J.

    2006-01-01

    In the past, generic models, restrictive budgets,and general shortages of resources have limited the scope of the UK's older Magnox simulators. Nevertheless, the simulators evolved slowly over time, becoming more like their reference plants, as resources became available. Three years ago, the Training and Development Branch of Magnox Electric plc took a giant leap, investing significant resources into the modernization of their training simulators. New hardware was built, including a new simulator room. The simulator software was ported from Unix running on outdated servers to new servers running Microsoft Windows NT. Perhaps most significantly, major model enhancements were made to key plant systems to significantly increase the likeness of each simulator to its reference plant. The upgrade to NT, the addition of state-of-the-art instructor stations, and some of the model enhancements were achieved with SimPort, an all-inclusive simulation package provided by DS and S. This paper will provide a more detailed view of the Magnox modular simulators, including how they are used and how they have benefited from the enhancements and upgrades implemented during the project. (author)

  10. Threshold enhancement of diphoton resonances

    Directory of Open Access Journals (Sweden)

    Aoife Bharucha

    2016-10-01

    Full Text Available We revisit a mechanism to enhance the decay width of (pseudo-scalar resonances to photon pairs when the process is mediated by loops of charged fermions produced near threshold. Motivated by the recent LHC data, indicating the presence of an excess in the diphoton spectrum at approximately 750 GeV, we illustrate this threshold enhancement mechanism in the case of a 750 GeV pseudoscalar boson A with a two-photon decay mediated by a charged and uncolored fermion having a mass at the 12MA threshold and a small decay width, <1 MeV. The implications of such a threshold enhancement are discussed in two explicit scenarios: i the Minimal Supersymmetric Standard Model in which the A state is produced via the top quark mediated gluon fusion process and decays into photons predominantly through loops of charginos with masses close to 12MA and ii a two Higgs doublet model in which A is again produced by gluon fusion but decays into photons through loops of vector-like charged heavy leptons. In both these scenarios, while the mass of the charged fermion has to be adjusted to be extremely close to half of the A resonance mass, the small total widths are naturally obtained if only suppressed three-body decay channels occur. Finally, the implications of some of these scenarios for dark matter are discussed.

  11. Integrating diverse datasets improves developmental enhancer prediction.

    Directory of Open Access Journals (Sweden)

    Genevieve D Erwin

    2014-06-01

    Full Text Available Gene-regulatory enhancers have been identified using various approaches, including evolutionary conservation, regulatory protein binding, chromatin modifications, and DNA sequence motifs. To integrate these different approaches, we developed EnhancerFinder, a two-step method for distinguishing developmental enhancers from the genomic background and then predicting their tissue specificity. EnhancerFinder uses a multiple kernel learning approach to integrate DNA sequence motifs, evolutionary patterns, and diverse functional genomics datasets from a variety of cell types. In contrast with prediction approaches that define enhancers based on histone marks or p300 sites from a single cell line, we trained EnhancerFinder on hundreds of experimentally verified human developmental enhancers from the VISTA Enhancer Browser. We comprehensively evaluated EnhancerFinder using cross validation and found that our integrative method improves the identification of enhancers over approaches that consider a single type of data, such as sequence motifs, evolutionary conservation, or the binding of enhancer-associated proteins. We find that VISTA enhancers active in embryonic heart are easier to identify than enhancers active in several other embryonic tissues, likely due to their uniquely high GC content. We applied EnhancerFinder to the entire human genome and predicted 84,301 developmental enhancers and their tissue specificity. These predictions provide specific functional annotations for large amounts of human non-coding DNA, and are significantly enriched near genes with annotated roles in their predicted tissues and lead SNPs from genome-wide association studies. We demonstrate the utility of EnhancerFinder predictions through in vivo validation of novel embryonic gene regulatory enhancers from three developmental transcription factor loci. Our genome-wide developmental enhancer predictions are freely available as a UCSC Genome Browser track, which we hope

  12. Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells into the Developing Mouse Eye

    International Nuclear Information System (INIS)

    Lee, Eun-Shil; Yu, Song-Hee; Jang, Yu-Jin; Hwang, Dong-Youn; Jeon, Chang-Jin

    2011-01-01

    Mesenchymal stem cells (MSCs) have been studied widely for their potential to differentiate into various lineage cells including neural cells in vitro and in vivo. To investigate the influence of the developing host environment on the integration and morphological and molecular differentiation of MSCs, human bone marrow-derived mesenchymal stem cells (BM-MSCs) were transplanted into the developing mouse retina. Enhanced green fluorescent protein (GFP)-expressing BM-MSCs were transplanted by intraocular injections into mice, ranging in ages from 1 day postnatal (PN) to 10 days PN. The survival dates ranged from 7 days post-transplantation (DPT) to 28DPT, at which time an immunohistochemical analysis was performed on the eyes. The transplanted BM-MSCs survived and showed morphological differentiation into neural cells and some processes within the host retina. Some transplanted cells expressed microtubule associated protein 2 (MAP2ab, marker for mature neural cells) or glial fibrillary acid protein (GFAP, marker for glial cells) at 5PN 7DPT. In addition, some transplanted cells integrated into the developing retina. The morphological and molecular differentiation and integration within the 5PN 7DPT eye was greater than those of other-aged host eye. The present findings suggest that the age of the host environment can strongly influence the differentiation and integration of BM-MSCs

  13. Differential effects of culture senescence and mechanical stimulation on the proliferation and leiomyogenic differentiation of MSC from different sources: implications for engineering vascular grafts.

    Science.gov (United States)

    Koobatian, Maxwell T; Liang, Mao-Shih; Swartz, Daniel D; Andreadis, Stelios T

    2015-04-01

    We examined the effects of senescence on the proliferation and leiomyogenic differentiation potential of mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs) or hair follicles (HF-MSCs). To this end, we compared ovine HF-MSCs and BM-MSCs in terms of their proliferation and differentiation potential to the smooth muscle cell lineage. We discovered that HF-MSCs are less susceptible to culture senescence compared with BM-MSCs. We hypothesized that application of mechanical forces may enhance the contractility and mechanical properties of vascular constructs prepared from senescent MSCs. Interestingly, HF-MSCs and BM-MSCs responded differently to changes in the mechanical microenvironment, suggesting that despite phenotypic similarities, MSCs from different anatomic locations may activate different pathways in response to the same microenvironmental factors. In turn, this may also suggest that cell-based tissue regeneration approaches may need to be tailored to the stem cell origin, donor age, and culture time for optimal results.

  14. Degenerate wave and capacitive coupling increase human MSC invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model.

    Directory of Open Access Journals (Sweden)

    Michelle Griffin

    Full Text Available Non-unions pose complications in fracture management that can be treated using electrical stimulation (ES. Bone marrow mesenchymal stem cells (BMMSCs are essential in fracture healing; however, the effect of different clinical ES waveforms on BMMSCs cellular activities remains unknown. We compared the effects of direct current (DC, capacitive coupling (CC, pulsed electromagnetic field (PEMF and degenerate wave (DW on cellular activities including cytotoxicity, proliferation, cell-kinetics and apoptosis by stimulating human-BMMSCs 3 hours a day, up to 5 days. In addition, migration and invasion were assessed using fluorescence microscopy and by quantifying gene and protein expression. We found that DW had the greatest proliferative and least apoptotic and cytotoxic effects compared to other waveforms. DC, DW and CC stimulations resulted in a higher number of cells in S phase and G(2/M phase as shown by cell cycle analysis. CC and DW caused more cells to invade collagen and showed increased MMP-2 and MT1-MMP expression. DC increased cellular migration in a scratch-wound assay and all ES waveforms enhanced expression of migratory genes with DC having the greatest effect. All ES treated cells showed similar progenitor potential as determined by MSC differentiation assay. All above findings were shown to be statistically significant (p<0.05. We conclude that ES can influence BMMSCs activities, especially DW and CC, which show greater invasion and higher cell proliferation compared to other types of ES. Application of DW or CC to the fracture site may help in the recruitment of BMMSCs to the wound that may enhance rate of bone healing at the fracture site.

  15. Analyzing Security-Enhanced Linux Policy Specifications

    National Research Council Canada - National Science Library

    Archer, Myla

    2003-01-01

    NSA's Security-Enhanced (SE) Linux enhances Linux by providing a specification language for security policies and a Flask-like architecture with a security server for enforcing policies defined in the language...

  16. DENdb: database of integrated human enhancers

    KAUST Repository

    Ashoor, Haitham

    2015-09-05

    Enhancers are cis-acting DNA regulatory regions that play a key role in distal control of transcriptional activities. Identification of enhancers, coupled with a comprehensive functional analysis of their properties, could improve our understanding of complex gene transcription mechanisms and gene regulation processes in general. We developed DENdb, a centralized on-line repository of predicted enhancers derived from multiple human cell-lines. DENdb integrates enhancers predicted by five different methods generating an enriched catalogue of putative enhancers for each of the analysed cell-lines. DENdb provides information about the overlap of enhancers with DNase I hypersensitive regions, ChIP-seq regions of a number of transcription factors and transcription factor binding motifs, means to explore enhancer interactions with DNA using several chromatin interaction assays and enhancer neighbouring genes. DENdb is designed as a relational database that facilitates fast and efficient searching, browsing and visualization of information.

  17. Complementary surface charge for enhanced capacitive deionization

    NARCIS (Netherlands)

    Gao, X.; Porada, S.; Omosebi, A.; Liu, K.L.; Biesheuvel, P.M.; Landon, J.

    2016-01-01

    Commercially available activated carbon cloth electrodes are treated using nitric acid and ethylenediamine solutions, resulting in chemical surface charge enhanced carbon electrodes for capacitive deionization (CDI) applications. Surface charge enhanced electrodes are then configured in a CDI

  18. Enhancing implementation security of QKD

    Science.gov (United States)

    Tamaki, Kiyoshi

    2017-10-01

    Quantum key distribution (QKD) can achieve information-theoretic security, which is a provable security against any eavesdropping, given that all the devices the sender and the receiver employ operate exactly as the theory of security requires. Unfortunately, however, it is difficult for practical devices to meet all such requirements, and therefore more works have to be done toward guaranteeing information-theoretic security in practice, i.e., implementation security. In this paper, we review our recent efforts to enhance implementation security. We also have a brief look at a flaw in security proofs and present how to fix it.

  19. Enhanced candu 6 reactor: status

    International Nuclear Information System (INIS)

    Azeez, S.; Girouard, P.

    2006-01-01

    The CANDU 6 power reactor is visionary in its approach, renowned for its on-power refuelling capability and proven over years of safe, economical and reliable power production. Developed by Atomic Energy of Canada Limited (AECL), the CANDU 6 design offers excellent performance utilizing state-of-the-art technology. The first CANDU 6 plants went into service in the early 1980s as leading edge technology and the design has been continuously advanced to maintain superior performance with an outstanding safety record. The first set of CANDU 6 plants - Gentilly 2 and Point Lepreau in Canada, Embalse in Argentina and Wolsong- Unit 1 in Korea - have been in service for more than 22 years and are still producing electricity at peak performance; to the end of 2004, their average Lifetime Capacity Factor was 83.2%. The newer CANDU 6 units in Romania (Cernavoda 1), Korea (Wolsong-Units 2, 3 and 4) and Qinshan (Phase III- Units 1 and 2) have also been performing at outstanding levels. The average lifetime Capacity Factor of the 10 CANDU 6 operating units around the world has been 87% to the end of 2004. Building on these successes, AECL is committed to the further development of this highly successful design, now focussing on meeting customers' needs for reduced costs, further improvements to plant operation and performance, enhanced safety and incorporating up-to-date technology, as warranted. This has resulted in AECL embarking on improving the CANDU 6 design through an upgraded product termed the ''Enhanced CANDU 6'' (EC6), which incorporates several attractive but proven features that make the CANDU 6 reactor even more economical, safer and easier to operate. Some of the key features that are being incorporated into the EC6 include increasing the plant's power output, shortening the overall project schedule, decreasing the capital cost, dealing with obsolescence issues, optimizing maintenance outages and incorporating lessons learnt through feedback obtained from the

  20. Gemstone enhancement by radiation treatment

    International Nuclear Information System (INIS)

    Desai, Shripal N.

    1998-01-01

    Since the discovery of radioactivity, investigations on the effects of atomic rays on precious stones began and Crookes established that alpha rays from radium produced green colour in diamonds. Gamma rays, x-rays, electrons, neutrons, protons etc. are effective in producing colour in precious stone like topaz and corundum. Some of these also produce considerable amount of radioactivity which is not acceptable if the radioactivity exceeds permissible limits. Colour enhancement by radiation treatment, different radiations, safety of irradiated gem stones and market related aspects are discussed. (author)

  1. ICT applications enhancing energy efficiency

    Directory of Open Access Journals (Sweden)

    A. G. Matani

    2016-06-01

    Full Text Available Computers, laptops and mobile devices – information technology (IT accounts for 2% of human greenhouse gas emissions worldwide, as evidenced in a study by Global Action Plan, a UK based environmental organization. This figure can be reduced if the green segment, or Green IT, continues to grow. Energy can also be saved through cloud computing, namely the principle of outsourcing the programs and functions of one’s own computer to service providers over the internet. This also means sharing storage capacity with others. This paper highlights the impact of information technology applications towards enhancing energy efficiency of the systems.

  2. Performance Enhancement by Brain Stimulation

    Directory of Open Access Journals (Sweden)

    Parisa Gazerani

    2017-09-01

    Full Text Available Number of substances and strategies are available to increase performance in sport (Catlin and Murray, 1996. Since 2004, the World Anti-Doping Agency (WADA posts an updated list of substances and methods prohibited to athletes. Drugs (e.g., steroids, stimulants are a major part of this list; however, technologies and methods (e.g., gene doping are increasingly being identified and added (WADA, 2017. Among technologies and methods that might exert a potential effect on athletic performance, brain stimulation has recently been subjected to extensive discussion. Neuro-enhancement for doping purposes has been termed “neurodoping” in the literature (Davis, 2013; however, this concept needs further documentation before the term “neurodoping” can be used properly. Two major non-invasive techniques of brain stimulations are transcranial magnetic stimulation (TMS (Hallett, 2007; Rossi et al., 2009, and transcranial direct current stimulation (tDCS (Stagg and Nitsche, 2011. In TMS, an electric coil held over the head applies magnetic pulses to create currents in the brain. In tDCS, a low, continuous electrical current is delivered to the brain by using surface electrodes attached on the scalp. TMS and tDCS have been used in both research and clinic (Shin and Pelled, 2017 for example to examine alterations in cognitive function or motor skills or to assist in recovering motor function after a stroke (Gomez Palacio Schjetnan et al., 2013 or reducing fatigue in patients with multiple sclerosis (Saiote et al., 2014. In an opinion paper, it was proposed that use of emerging brain stimulation techniques might also enhance physical and mental performance in sports (Davis, 2013. The assumption was based on several reports. For example some studies have shown that TMS could shorten reaction times to visual, auditory and touch stimuli, reduce tremor, and enhance the acquisition of complex motor skills. Based on the current evidence, a recent review (Colzato

  3. Directing a Quality Enhancement Plan

    Directory of Open Access Journals (Sweden)

    Ronald A. Styron, Jr.

    2015-08-01

    Full Text Available This paper is drawn from a project aimed at enhancing the quality of instructional practice and improving studentlearning outcomes in classes across an urban university located in the southern region of the United States. The strategies, employed by the project leader, are discussed in detail as framed by a new problem-solving leadership design called the Alloy Improvement Model (AIM. Data collected at the end of the second full year and reported in this paper indicated all project goals were met and that the utilization of the AIM was central to project success.

  4. Fibronectin enhances transfection of Staphylococcus aureus.

    OpenAIRE

    Thompson, N E; Bergdoll, M S; Pattee, P A

    1985-01-01

    The factor in normal sera primarily responsible for the enhancement of transfection (and transformation) of Staphylococcus aureus was identified as fibronectin. Serum samples which were depleted of fibronectin by affinity chromatography showed a marked decrease in enhancing activity. Fibronectin isolated from sera of several animal species demonstrated enhancing activity.

  5. Textual Enhancement of Input: Issues and Possibilities

    Science.gov (United States)

    Han, ZhaoHong; Park, Eun Sung; Combs, Charles

    2008-01-01

    The input enhancement hypothesis proposed by Sharwood Smith (1991, 1993) has stimulated considerable research over the last 15 years. This article reviews the research on textual enhancement of input (TE), an area where the majority of input enhancement studies have aggregated. Methodological idiosyncrasies are the norm of this body of research.…

  6. Visualization of enhancer-derived noncoding RNA

    CSIR Research Space (South Africa)

    Shibayama, Y

    2017-01-01

    Full Text Available Enhancers are principal regulators that allow spatiotemporal tissue-specifi c control of gene expression. While mounting evidence suggests that enhancer-derived long noncoding RNAs (long ncRNAs), including enhancer RNAs (eRNAs), are an important...

  7. Enhanced Gain in Photonic Crystal Amplifiers

    DEFF Research Database (Denmark)

    Ek, Sara; Semenova, Elizaveta; Hansen, Per Lunnemann

    2012-01-01

    We experimentally demonstrate enhanced gain in the slow-light regime of quantum well photonic crystal amplifiers. A strong gain enhancement is observed with the increase of the group refractive index, due to light slow-down. The slow light enhancement is shown in a amplified spontaneous emission...

  8. Chemical Penetration Enhancers for Transdermal Drug Delivery ...

    African Journals Online (AJOL)

    for transdermal administration. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, we have discussed the chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

  9. RTU Comparison Calculator Enhancement Plan

    Energy Technology Data Exchange (ETDEWEB)

    Miller, James D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Katipamula, Srinivas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-01

    Over the past two years, Department of Energy’s Building Technologies Office (BTO) has been investigating ways to increase the operating efficiency of the packaged rooftop units (RTUs) in the field. First, by issuing a challenge to the RTU manufactures to increase the integrated energy efficiency ratio (IEER) by 60% over the existing ASHRAE 90.1-2010 standard. Second, by evaluating the performance of an advanced RTU controller that reduces the energy consumption by over 40%. BTO has previously also funded development of a RTU comparison calculator (RTUCC). RTUCC is a web-based tool that provides the user a way to compare energy and cost savings for two units with different efficiencies. However, the RTUCC currently cannot compare savings associated with either the RTU Challenge unit or the advanced RTU controls retrofit. Therefore, BTO has asked PNNL to enhance the tool so building owners can compare energy and savings associated with this new class of products. This document provides the details of the enhancements that are required to support estimating energy savings from use of RTU challenge units or advanced controls on existing RTUs.

  10. RTU Comparison Calculator Enhancement Plan

    Energy Technology Data Exchange (ETDEWEB)

    Miller, James D.; Wang, Weimin; Katipamula, Srinivas

    2014-03-31

    Over the past two years, Department of Energy’s Building Technologies Office (BTO) has been investigating ways to increase the operating efficiency of the packaged rooftop units (RTUs) in the field. First, by issuing a challenge to the RTU manufactures to increase the integrated energy efficiency ratio (IEER) by 60% over the existing ASHRAE 90.1-2010 standard. Second, by evaluating the performance of an advanced RTU controller that reduces the energy consumption by over 40%. BTO has previously also funded development of a RTU comparison calculator (RTUCC). RTUCC is a web-based tool that provides the user a way to compare energy and cost savings for two units with different efficiencies. However, the RTUCC currently cannot compare savings associated with either the RTU Challenge unit or the advanced RTU controls retrofit. Therefore, BTO has asked PNNL to enhance the tool so building owners can compare energy and savings associated with this new class of products. This document provides the details of the enhancements that are required to support estimating energy savings from use of RTU challenge units or advanced controls on existing RTUs.

  11. Enhancing avifauna in commercial plantations.

    Science.gov (United States)

    Nájera, Andrea; Simonetti, Javier A

    2010-02-01

    The occurrence of fauna in commercial plantations is often associated with structural complexity. Through a meta-analysis, we tested whether the structural complexity of plantations could enhance bird species assemblages and whether bird assemblages respond differently depending on taxonomic affiliation, body size, and diet. Our analyses included 167 case studies in 31 countries in which bird assemblages in forests and plantations were compared and 42 case studies in 14 countries in which bird assemblages in plantations of different structural complexity were compared. Species richness, but not abundance, was higher in forests than in plantations. Both species richness and abundance were significantly higher in complex than in structurally simple plantations. Taxonomic representation and body size did not differ between forest and plantations, except that there were fewer insectivorous birds in plantations than in forests. In the comparison of simple versus complex plantations, abundance of all taxonomic and dietary groups was higher in complex plantations. Body size did not affect bird species richness or abundance. Independent of the type of plantation, bird richness and abundance were greater in structurally complex plantations. Enhancing the structural complexity of plantations may mitigate their impact and offer habitat for some native species.

  12. Psychopharmacological enhancement: a conceptual framework.

    Science.gov (United States)

    Stein, Dan J

    2012-01-13

    The availability of a range of new psychotropic agents raises the possibility that these will be used for enhancement purposes (smart pills, happy pills, and pep pills). The enhancement debate soon raises questions in philosophy of medicine and psychiatry (eg, what is a disorder?), and this debate in turn raises fundament questions in philosophy of language, science, and ethics. In this paper, a naturalistic conceptual framework is proposed for addressing these issues. This framework begins by contrasting classical and critical concepts of categories, and then puts forward an integrative position that is based on cognitive-affective research. This position can in turn be used to consider the debate between pharmacological Calvinism (which may adopt a moral metaphor of disorder) and psychotropic utopianism (which may emphasize a medical metaphor of disorder). I argue that psychiatric treatment of serious psychiatric disorders is justified, and that psychotropics are an acceptable kind of intervention. The use of psychotropics for sub-threshold phenomena requires a judicious weighing of the relevant facts (which are often sparse) and values.

  13. Psychopharmacological enhancement: a conceptual framework

    Directory of Open Access Journals (Sweden)

    Stein Dan J

    2012-01-01

    Full Text Available Abstract The availability of a range of new psychotropic agents raises the possibility that these will be used for enhancement purposes (smart pills, happy pills, and pep pills. The enhancement debate soon raises questions in philosophy of medicine and psychiatry (eg, what is a disorder?, and this debate in turn raises fundament questions in philosophy of language, science, and ethics. In this paper, a naturalistic conceptual framework is proposed for addressing these issues. This framework begins by contrasting classical and critical concepts of categories, and then puts forward an integrative position that is based on cognitive-affective research. This position can in turn be used to consider the debate between pharmacological Calvinism (which may adopt a moral metaphor of disorder and psychotropic utopianism (which may emphasize a medical metaphor of disorder. I argue that psychiatric treatment of serious psychiatric disorders is justified, and that psychotropics are an acceptable kind of intervention. The use of psychotropics for sub-threshold phenomena requires a judicious weighing of the relevant facts (which are often sparse and values.

  14. An enhanced splined saddle method

    Science.gov (United States)

    Ghasemi, S. Alireza; Goedecker, Stefan

    2011-07-01

    We present modifications for the method recently developed by Granot and Baer [J. Chem. Phys. 128, 184111 (2008)], 10.1063/1.2916716. These modifications significantly enhance the efficiency and reliability of the method. In addition, we discuss some specific features of this method. These features provide important flexibilities which are crucial for a double-ended saddle point search method in order to be applicable to complex reaction mechanisms. Furthermore, it is discussed under what circumstances this methods might fail to find the transition state and remedies to avoid such situations are provided. We demonstrate the performance of the enhanced splined saddle method on several examples with increasing complexity, isomerization of ammonia, ethane and cyclopropane molecules, tautomerization of cytosine, the ring opening of cyclobutene, the Stone-Wales transformation of the C60 fullerene, and finally rolling a small NaCl cube on NaCl(001) surface. All of these calculations are based on density functional theory. The efficiency of the method is remarkable in regard to the reduction of the total computational time.

  15. Enhancing poxvirus vectors vaccine immunogenicity.

    Science.gov (United States)

    García-Arriaza, Juan; Esteban, Mariano

    2014-01-01

    Attenuated recombinant poxvirus vectors expressing heterologous antigens from pathogens are currently at various stages in clinical trials with the aim to establish their efficacy. This is because these vectors have shown excellent safety profiles, significant immunogenicity against foreign expressed antigens and are able to induce protective immune responses. In view of the limited efficacy triggered by some poxvirus strains used in clinical trials (i.e, ALVAC in the RV144 phase III clinical trial for HIV), and of the restrictive replication capacity of the highly attenuated vectors like MVA and NYVAC, there is a consensus that further improvements of these vectors should be pursuit. In this review we considered several strategies that are currently being implemented, as well as new approaches, to improve the immunogenicity of the poxvirus vectors. This includes heterologous prime/boost protocols, use of co-stimulatory molecules, deletion of viral immunomodulatory genes still present in the poxvirus genome, enhancing virus promoter strength, enhancing vector replication capacity, optimizing expression of foreign heterologous sequences, and the combined use of adjuvants. An optimized poxvirus vector triggering long-lasting immunity with a high protective efficacy against a selective disease should be sought.

  16. ENPEP model enhancements at ANL

    International Nuclear Information System (INIS)

    Guziel, K.A.

    1997-01-01

    Argonne National Laboratory (ANL) has been involved in energy and electricity planning analyses for almost 20 years. Their activities include the development of analytical tools and methodologies along with their application to a wide variety of national energy planning studies. The methodologies cover all aspects of energy planning. In response to a request by the US Department of Energy (USDOE) to integrate existing tools into a package that could be distributed to developing countries for their own use, the ENergy and Power Evaluation Program (ENPEP) was developed. The USDOE wanted an all purpose tool that would allow the user to do a complete energy analysis, from demand forecast through primary energy resources allocation to electricity generation system expansion plan and environmental analysis. Since its original development, the ENPEP modules have been improved and enhanced to incorporate advancements in computer hardware and software technology, as well as to correct bugs that were identified in the programs. In cooperation with other organizations (e.g. The World Bank - IBRD - and the International Atomic Energy Agency - IAEA -), the ENPEP package has been used at national, regional and inter-regional training courses, as well as in the conduct of national energy/electricity planning studies. This paper reviews the development of the ENPEP package and the proposed enhancements to the package. (author). 1 fig., 2 tabs

  17. Enhanced Video-Oculography System

    Science.gov (United States)

    Moore, Steven T.; MacDougall, Hamish G.

    2009-01-01

    A previously developed video-oculography system has been enhanced for use in measuring vestibulo-ocular reflexes of a human subject in a centrifuge, motor vehicle, or other setting. The system as previously developed included a lightweight digital video camera mounted on goggles. The left eye was illuminated by an infrared light-emitting diode via a dichroic mirror, and the camera captured images of the left eye in infrared light. To extract eye-movement data, the digitized video images were processed by software running in a laptop computer. Eye movements were calibrated by having the subject view a target pattern, fixed with respect to the subject s head, generated by a goggle-mounted laser with a diffraction grating. The system as enhanced includes a second camera for imaging the scene from the subject s perspective, and two inertial measurement units (IMUs) for measuring linear accelerations and rates of rotation for computing head movements. One IMU is mounted on the goggles, the other on the centrifuge or vehicle frame. All eye-movement and head-motion data are time-stamped. In addition, the subject s point of regard is superimposed on each scene image to enable analysis of patterns of gaze in real time.

  18. Threshold enhancement of diphoton resonances

    CERN Document Server

    Bharucha, Aoife; Goudelis, Andreas

    2016-10-10

    The data collected by the LHC collaborations at an energy of 13 TeV indicates the presence of an excess in the diphoton spectrum that would correspond to a resonance of a 750 GeV mass. The apparently large production cross section is nevertheless very difficult to explain in minimal models. We consider the possibility that the resonance is a pseudoscalar boson $A$ with a two--photon decay mediated by a charged and uncolored fermion having a mass at the $\\frac12 M_A$ threshold and a very small decay width, $\\ll 1$ MeV; one can then generate a large enhancement of the $A\\gamma\\gamma$ amplitude which explains the excess without invoking a large multiplicity of particles propagating in the loop, large electric charges and/or very strong Yukawa couplings. The implications of such a threshold enhancement are discussed in two explicit scenarios: i) the Minimal Supersymmetric Standard Model in which the $A$ state is produced via the top quark mediated gluon fusion process and decays into photons predominantly through...

  19. Optical antenna enhanced spontaneous emission.

    Science.gov (United States)

    Eggleston, Michael S; Messer, Kevin; Zhang, Liming; Yablonovitch, Eli; Wu, Ming C

    2015-02-10

    Atoms and molecules are too small to act as efficient antennas for their own emission wavelengths. By providing an external optical antenna, the balance can be shifted; spontaneous emission could become faster than stimulated emission, which is handicapped by practically achievable pump intensities. In our experiments, InGaAsP nanorods emitting at ∼ 200 THz optical frequency show a spontaneous emission intensity enhancement of 35 × corresponding to a spontaneous emission rate speedup ∼ 115 ×, for antenna gap spacing, d = 40 nm. Classical antenna theory predicts ∼ 2,500 × spontaneous emission speedup at d ∼ 10 nm, proportional to 1/d(2). Unfortunately, at d antenna efficiency drops below 50%, owing to optical spreading resistance, exacerbated by the anomalous skin effect (electron surface collisions). Quantum dipole oscillations in the emitter excited state produce an optical ac equivalent circuit current, I(o) = qω|x(o)|/d, feeding the antenna-enhanced spontaneous emission, where q|x(o)| is the dipole matrix element. Despite the quantum-mechanical origin of the drive current, antenna theory makes no reference to the Purcell effect nor to local density of states models. Moreover, plasmonic effects are minor at 200 THz, producing only a small shift of antenna resonance frequency.

  20. Enhancing protection for vulnerable waters

    Science.gov (United States)

    Creed, Irena F.; Lane, Charles R.; Serran, Jacqueline N.; Alexander, Laurie C.; Basu, Nandita B.; Calhoun, Aram J. K.; Christensen, Jay R.; Cohen, Matthew J.; Craft, Christopher; D'Amico, Ellen; Dekeyser, Edward; Fowler, Laurie; Golden, Heather E.; Jawitz, James W.; Kalla, Peter; Kirkman, L. Katherine; Lang, Megan; Leibowitz, Scott G.; Lewis, David B.; Marton, John; McLaughlin, Daniel L.; Raanan-Kiperwas, Hadas; Rains, Mark C.; Rains, Kai C.; Smith, Lora

    2017-11-01

    Governments worldwide do not adequately protect their limited freshwater systems and therefore place freshwater functions and attendant ecosystem services at risk. The best available scientific evidence compels enhanced protections for freshwater systems, especially for impermanent streams and wetlands outside of floodplains that are particularly vulnerable to alteration or destruction. New approaches to freshwater sustainability -- implemented through scientifically informed adaptive management -- are required to protect freshwater systems through periods of changing societal needs. One such approach introduced in the US in 2015 is the Clean Water Rule, which clarified the jurisdictional scope for federally protected waters. However, within hours of its implementation litigants convinced the US Court of Appeals for the Sixth Circuit to stay the rule, and the subsequently elected administration has now placed it under review for potential revision or rescission. Regardless of its outcome at the federal level, policy and management discussions initiated by the propagation of this rare rulemaking event have potential far-reaching implications at all levels of government across the US and worldwide. At this timely juncture, we provide a scientific rationale and three policy options for all levels of government to meaningfully enhance protection of these vulnerable waters. A fourth option, a 'do-nothing' approach, is wholly inconsistent with the well-established scientific evidence of the importance of these vulnerable waters.

  1. Meningeal enhancement on MRI after craniotomy

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Motohiro; Hasegawa, Mitsuhiro; Yamashima, Tetsumori; Yamashita, Junkoh; Suzuki, Masayuki (Kanazawa Univ. (Japan). School of Medicine)

    1991-08-01

    Gd-DPTA-enhanced MR images in 94 patients who had undergone craniotomy were studied, with particular attention paid to the meningeal enhancement. Such enhancement was noted in 26 of the 94 (27.6%) in the portion surrounding the craniotomy site. Meningeal enhancement, presumably of the subdural neomembrane, was apparent as a third line of a high signal intensity on T{sub 1}-weighted MR images. The outer two high-intensity lines were derived from fat in the subcutaneous tissues of the scalp and fat in the bone marrow of the calvaria. We designated this characteristic enhancement as a 'triple white line'. Of the 26 patients with meningeal enhancement, 22 cases (23.4%) showed such a 'triple white line', 11 cases (11.7%) showed falx enhancement, and 12 cases (12.8%) showed tentorial enhancement. The intervals between surgery and the appearance of the meningeal enhancement ranged from 4 days to 88 weeks. A small amount of bleeding into the dura-arachnoid interface induced by surgery might result in the subdural neomembrane, as has previously been reported. This neomembrane might be enhanced by the leakage of Gd-DTPA through the proliferating capillaries. As meningeal enhancement occurs in approximately a third of the cases following craniotomy, much care should be taken in the differential diagnosis of the infection, inflammation, and metastasis or dissemination of malignant brain tumors. (author).

  2. Meningeal enhancement on MRI after craniotomy

    International Nuclear Information System (INIS)

    Nomura, Motohiro; Hasegawa, Mitsuhiro; Yamashima, Tetsumori; Yamashita, Junkoh; Suzuki, Masayuki

    1991-01-01

    Gd-DPTA-enhanced MR images in 94 patients who had undergone craniotomy were studied, with particular attention paid to the meningeal enhancement. Such enhancement was noted in 26 of the 94 (27.6%) in the portion surrounding the craniotomy site. Meningeal enhancement, presumably of the subdural neomembrane, was apparent as a third line of a high signal intensity on T 1 -weighted MR images. The outer two high-intensity lines were derived from fat in the subcutaneous tissues of the scalp and fat in the bone marrow of the calvaria. We designated this characteristic enhancement as a 'triple white line'. Of the 26 patients with meningeal enhancement, 22 cases (23.4%) showed such a 'triple white line', 11 cases (11.7%) showed falx enhancement, and 12 cases (12.8%) showed tentorial enhancement. The intervals between surgery and the appearance of the meningeal enhancement ranged from 4 days to 88 weeks. A small amount of bleeding into the dura-arachnoid interface induced by surgery might result in the subdural neomembrane, as has previously been reported. This neomembrane might be enhanced by the leakage of Gd-DTPA through the proliferating capillaries. As meningeal enhancement occurs in approximately a third of the cases following craniotomy, much care should be taken in the differential diagnosis of the infection, inflammation, and metastasis or dissemination of malignant brain tumors. (author)

  3. Pelleted bone marrow derived mesenchymal stem cells are better protected from the deleterious effects of arthroscopic heat shock

    Directory of Open Access Journals (Sweden)

    Gauthaman eKalamegam

    2016-05-01

    Full Text Available Introduction: The impact of arthroscopic temperature on joint tissues is poorly understood and it is not known how mesenchymal stem cells (MSCs respond to the effects of heat generated by the device during the process of arthroscopy assisted experimental cell-based therapy. In the present study, we isolated and phenotypically characterized human bone marrow mesenchymal stem cells (hBMMSCs from osteoarthritis (OA patients, and evaluated the effect of arthroscopic heat on cell viability in suspension and pellet cultures.Methods: Primary cultures of hBMMSCs were isolated from bone marrow aspirates of OA patients and cultured using DMEM supplemented with 10% FBS and characterized for their stemness. hBMMSCs (1 x 106 cells cultured as single cell suspensions or cell pellets were exposed to an illuminated arthroscope for 10, 20 or 30 min. This was followed by analysis of cellular proliferation and heat shock related gene expression. Results: hBMMSCs were viable and exhibited population doubling, short spindle morphology, MSC related CD surface markers expression and tri-lineage differentiation into adipocytes, chondrocytes and osteoblasts. Chondrogenic and osteogenic differentiation increased collagen production and alkaline phosphatase activity. Exposure of hBMMSCs to an illuminated arthroscope for 10, 20 or 30 min for 72 h decreased cell proliferation in cell suspensions (63.27% at 30 min and increased cell proliferation in cell pellets (62.86% at 10 min and 68.57% at 20 min. hBMMSCs exposed to 37C, 45C and 55C for 120 seconds demonstrated significant upregulation of BAX, P53, Cyclin A2, Cyclin E1, TNF-α, and HSP70 in cell suspensions compared to cell pellets. Conclusions: hBMMSC cell pellets are better protected from temperature alterations compared to cell suspensions. Transplantation of hBMMSCs as pellets rather than as cell suspensions to the cartilage defect site would therefore support their viability and may aid enhanced cartilage

  4. Voluntary attention enhances contrast appearance.

    Science.gov (United States)

    Liu, Taosheng; Abrams, Jared; Carrasco, Marisa

    2009-03-01

    Voluntary (endogenous, sustained) covert spatial attention selects relevant sensory information for prioritized processing. The behavioral and neural consequences of such selection have been extensively documented, but its phenomenology has received little empirical investigation. We asked whether voluntary attention affects the subjective appearance of contrast--a fundamental dimension of visual perception. We used a demanding rapid serial visual presentation (RSVP) task to direct endogenous attention to a given location and measured perceived contrast at the attended and unattended locations. Attention increased perceived contrast of suprathreshold stimuli and also improved performance on a concurrent orientation discrimination task at the cued location. We ruled out response bias as an alternative account of the pattern of results. Thus, this study establishes that voluntary attention enhances perceived contrast. This phenomenological consequence links behavioral and neurophysiological studies on the effects of attention.

  5. Research for enhancing reactor safety

    International Nuclear Information System (INIS)

    1989-05-01

    Recent research for enhanced reactor safety covers extensive and numerous experiments and computed modelling activities designed to verify and to improve existing design requirements. The lectures presented at the meeting report GRS research results and the current status of reactor safety research in France. The GRS experts present results concerning expert systems and their perspectives in safety engineering, large-scale experiments and their significance in the development and verification of computer codes for thermohydraulic modelling of safety-related incidents, the advanced system code ATHLET for analysis of thermohydraulic processes of incidents, the analysis simulator which is a tool for fast evaluation of accident management measures, and investigations into event sequences and the required preventive emergency measures within the German Risk Study. (DG) [de

  6. Shale Oil Value Enhancement Research

    Energy Technology Data Exchange (ETDEWEB)

    James W. Bunger

    2006-11-30

    Raw kerogen oil is rich in heteroatom-containing compounds. Heteroatoms, N, S & O, are undesirable as components of a refinery feedstock, but are the basis for product value in agrochemicals, pharmaceuticals, surfactants, solvents, polymers, and a host of industrial materials. An economically viable, technologically feasible process scheme was developed in this research that promises to enhance the economics of oil shale development, both in the US and elsewhere in the world, in particular Estonia. Products will compete in existing markets for products now manufactured by costly synthesis routes. A premium petroleum refinery feedstock is also produced. The technology is now ready for pilot plant engineering studies and is likely to play an important role in developing a US oil shale industry.

  7. Photosynthesis solutions to enhance productivity.

    Science.gov (United States)

    Foyer, Christine H; Ruban, Alexander V; Nixon, Peter J

    2017-09-26

    The concept that photosynthesis is a highly inefficient process in terms of conversion of light energy into biomass is embedded in the literature. It is only in the past decade that the processes limiting photosynthetic efficiency have been understood to an extent that allows a step change in our ability to manipulate light energy assimilation into carbon gain. We can therefore envisage that future increases in the grain yield potential of our major crops may depend largely on increasing the efficiency of photosynthesis. The papers in this issue provide new insights into the nature of current limitations on photosynthesis and identify new targets that can be used for crop improvement, together with information on the impacts of a changing environment on the productivity of photosynthesis on land and in our oceans.This article is part of the themed issue 'Enhancing photosynthesis in crop plants: targets for improvement'. © 2017 The Author(s).

  8. The Game Enhanced Learning Model

    DEFF Research Database (Denmark)

    Reng, Lars; Schoenau-Fog, Henrik

    2016-01-01

    In this paper, we will introduce the Game Enhanced learning Model (GEM), which describes a range of gameoriented learning activities. The model is intended to give an overview of the possibilities of game-based learning in general and all the way up to purposive game productions. In the paper, we...... will describe the levels of the model, which is based on our experience in teaching professional game development at university level. Furthermore, we have been using the model to inspire numerous educators to improve their students’ motivation and skills. The model presents various game-based learning...... activities, and depicts their required planning and expected outcome through eight levels. At its lower levels, the model contains the possibilities of using stand-alone analogue and digital games as teachers, utilizing games as a facilitator of learning activities, exploiting gamification and motivating...

  9. Enhancing undergraduate students’ communications skills

    DEFF Research Database (Denmark)

    Jørgensen, Merete; Witt, Klaus; Fridorff-Jens, Peter Kindt

    2014-01-01

    19729 Abstract Title: Enhancing undergraduate students communications skills Abstract Authors: •Merete Jorgensen, Copenhagen University , Family Medicine , Copenhagen •Klaus Witt, Research Unit , Family Medicine , Copenhagen •Peter Kindt Fridorff-Jens, Copenhagen University , IT-unit , Copenhagen...... the Consultation Logic (CL) and Consultation Analysis (CA), based on the Patient-Centred Consultation. To investigate the effect of various teaching methods in communication skills we have developed a scientific tool (DanSCORE) based on CL and CA to measure the students analysing ability Summary of work It has...... and they alternate with five plus four hour’s sessions of assessing, analyzing and discussion the videos in small groups with a peer (university teacher) and fellow students.We focus in our project on communication skills. 600 medical students are enrolled in the project. Changes in analyzing ability...

  10. Contrast-enhanced peripheral MRA

    DEFF Research Database (Denmark)

    Nielsen, Yousef W; Thomsen, Henrik S

    2012-01-01

    -state MRA. Gadolinium(Gd)-based contrast agents are used for CE-MRA of the peripheral arteries. Extracellular Gd agents have a pharmacokinetic profile similar to iodinated contrast media. Accordingly, these agents are employed for first-pass MRA. Blood-pool Gd-based agents are characterized by prolonged......In the last decade contrast-enhanced magnetic resonance angiography (CE-MRA) has gained wide acceptance as a valuable tool in the diagnostic work-up of patients with peripheral arterial disease. This review presents current concepts in peripheral CE-MRA with emphasis on MRI technique and contrast...... MRI contrast agent is injected intravenously and T1-weighted images are acquired in the subsequent arterial first-pass phase. In order to achieve high quality MR angiograms without interfering venous contamination or artifacts, a number of factors need to be taken into account. This includes magnetic...

  11. Contrast-enhanced endoscopic ultrasonography

    DEFF Research Database (Denmark)

    Reddy, Nischita K; Ioncică, Ana Maria; Săftoiu, Adrian

    2011-01-01

    Contrast agents are increasingly being used to characterize the vasculature in an organ of interest, to better delineate benign from malignant pathology and to aid in staging and directing therapeutic procedures. We review the mechanisms of action of first, second and third generation contrast...... agents and their use in various endoscopic procedures in the gastrointestinal tract. Various applications of contrast-enhanced endoscopic ultrasonography include differentiating benign from malignant mediastinal lymphadenopathy, assessment of depth of invasion of esophageal, gastric and gall bladder...... cancers and visualization of the portal venous system and esophageal varices. In addition, contrast agents can be used to differentiate pancreatic lesions. The use of color Doppler further increases the ability to diagnose and differentiate various pancreatic malignancies. The sensitivity of power Doppler...

  12. Enhanced Li-Ion Battery

    Directory of Open Access Journals (Sweden)

    Natasha Ross

    2015-01-01

    Full Text Available Au with Pd nanoparticles were synthesized and coated onto the spinel LiMn2O4 via a coprecipitation calcination method with the objective to improve the microstructure, conductivity, and electrochemical activities of pristine LiMn2O4. The novel LiPdAuxMn2-xO4 composite cathode had high phase purity, well crystallized particles, and more regular morphological structures with narrow size distributions. At enlarged cycling potential ranges the LiPdAuxMn2-xO4 sample delivered 90 mAh g−1 discharge capacity compared to LiMn2O4 (45 mAh g−1. It was concluded that even a small amount of the Pd and Au enhanced both the lithium diffusivity and electrochemical conductivity of the host sample due to the beneficial properties of their synergy.

  13. Unrequited: neurochemical enhancement of love.

    Science.gov (United States)

    Bamford, Rebecca

    2015-07-01

    I raise several concerns with Earp and colleagues' analysis of enhancement through neurochemical modulation of love as a key issue in contemporary neuroethics. These include: (i) strengthening their deflation of medicalization concerns by showing how the objection that love should be left outside of the scope of medicine would directly undermine the goal of medicine; (ii) developing stronger analysis of the social and political concerns relevant to neurochemical modulation of love, by exploring and suggesting possible counters to ways in which 'wellbeing' may be used as a tool of oppression; (iii) providing reasons to support a broad need for ecological investigation of, and indeed ecological education concerning, neurotechnology; (iv) suggesting ways in which philosophy, and the humanities more broadly, remain directly relevant to responding effectively to issues in contemporary neuroethics.

  14. Enhanced NIF neutron activation diagnostics.

    Science.gov (United States)

    Yeamans, C B; Bleuel, D L; Bernstein, L A

    2012-10-01

    The NIF neutron activation diagnostic suite relies on removable activation samples, leading to operational inefficiencies and a fundamental lower limit on the half-life of the activated product that can be observed. A neutron diagnostic system measuring activation of permanently installed samples could remove these limitations and significantly enhance overall neutron diagnostic capabilities. The physics and engineering aspects of two proposed systems are considered: one measuring the (89)Zr/(89 m)Zr isomer ratio in the existing Zr activation medium and the other using potassium zirconate as the activation medium. Both proposed systems could improve the signal-to-noise ratio of the current system by at least a factor of 5 and would allow independent measurement of fusion core velocity and fuel areal density.

  15. Enhanced High Resolution RBS System

    Science.gov (United States)

    Pollock, Thomas J.; Hass, James A.; Klody, George M.

    2011-06-01

    Improvements in full spectrum resolution with the second NEC high resolution RBS system are summarized. Results for 50 Å TiN/HfO films on Si yielding energy resolution on the order of 1 keV are also presented. Detector enhancements include improved pulse processing electronics, upgraded shielding for the MCP/RAE detector, and reduced noise generated from pumping. Energy resolution measurements on spectra front edge coupled with calculations using 0.4mStr solid angle show that beam energy spread at 400 KeV from the Pelletron® accelerator is less than 100 eV. To improve user throughput, magnet control has been added to the automatic data collection. Depth profiles derived from experimental data are discussed. For the thin films profiled, depth resolutions were on the Angstrom level with the non-linear energy/channel conversions ranging from 100 to 200 eV.

  16. Enhancing undergraduate students’ communications skills

    DEFF Research Database (Denmark)

    Jørgensen, Merete; Witt, Klaus; Fridorff-Jens, Peter Kindt

    2014-01-01

    ,Monika Bullinger,Matthias Rose, Sylke Andreas.Enhancing medical students' communication skills: development and evaluation of an undergraduate training program.Published online 2012 March 24. doi: 10.1186/1472-6920-12-16 2.William T. Branch, Jr, MD; David Kern, MD; Paul Haidet, MD, MPH; Peter Weissmann, MD...... Abstract Presenter(s): •Merete Jorgensen, Copenhagen University , Family Medicine , Øster Farigmagsgade 5 , 1014 , K , Denmark , mejor@sund.ku.dk Abstract: Background Being teachers in Clinical Course of Family Medicine since 1995, we have developed two schemes for communication analysing purposes called...... and they alternate with five plus four hour’s sessions of assessing, analyzing and discussion the videos in small groups with a peer (university teacher) and fellow students.We focus in our project on communication skills. 600 medical students are enrolled in the project. Changes in analyzing ability...

  17. Enhanced performance hybrid-arq

    KAUST Repository

    Fareed, Muhammad Mehboob

    2016-06-16

    Apparatuses, computer readable media, and methods are provided for enhancing hybrid automatic repeat request (ARQ) performance. In an example method, a communication device transmits a first element of a vector, where the vector is selected using the information bits to be transmitted as an index in a code book. In some embodiments, this code book is constructed using Linear Constellation Precoding (LCP). If a NACK is received, the communication device transmits a second element of the vector. The process of transmitting elements of the vector continues until an ACK is received or the maximum number of transmission attempts is reached. If an ACK is received, the communication device transmits a first element of another vector of the code book that encodes a second set of information bits. This procedure may continue until all information bits have been transmitted successfully.

  18. Delayed enhanced MRI in intraparenchymal tumors

    International Nuclear Information System (INIS)

    Eguchi, Takahiko; Morimoto, Tetsuya; Takeshima, Toshikazu

    1991-01-01

    Delayed enhanced MRI was performed on 20 intraparenchymal tumors, and these findings were compared with those of early enhanced MRI. Using the spin-echo technique (SE: 400-500/20 msec), early scans were obtained 5 minutes, and delayed scans were obtained 60 minutes, after the intravenous injection of 0.1 nmol of gadolinium-DTPA/Kg. We discussed the changes in the delayed scan with regard to the change in the pattern of enhancement and the boundary of enhancement. In these twenty intraparenchymal tumors, there were three low-grade astrocytomas, two anaplastic astrocytomas, seven glioblastomas, and eight metastatic tumors. The changes in the enhanced pattern showed three types as follows: Type I: heterogeneous enhancement in both early and delayed scans; Type II: heterogeneous enhancement in early scan and homogeneous enhancement in delayed scan; Type III: homogeneous enhancement in both early and delayed scans. Most malignant tumors, such as glioblastomas (6/8), anaplastic astrocytomas (2/2), and metastatic tumors (7/8), revealed Type I, although low-grade astrocytomas showed Type II (3/2) and Type III (1/3). The heterogeneous enhancement in delayed scan was found in malignant tumors and in low-grade astrocytoma; even if the early scan revealed heterogeneous enhancement, the delayed scan showed homogeneous enhancement. In the delayed scan, most enhanced boundaries spread out of the boundaries in the early scan. Glioblastomas spread markedly in the delayed scan, although none of the low-grade astrocytomas, anaplastic astrocytomas, or metastases revealed marked spreading. We called these marked increases in the delayed scan a 'spreading sign' and thought that this sign was specific to glioblastomas. Recently some authors have emphasized the usefulness of serial scans. Delayed enhanced MRI 60 minutes after the administration of a contrast medium was here found also to be useful for the accurate diagnosis for brain tumors. (author)

  19. Does groundwater enhance evaporative cooling?

    Science.gov (United States)

    Rouholahnejad, E.

    2015-12-01

    Evaporation is a key process in land-climate interactions, not only because it directly regulates the hydrological cycle, but also because it contributes to the Earth's energy balance. Due to its feedbacks on large-scale water processes and its impact on the dynamics of the atmosphere, it has been considered as a driver of droughts and heatwaves1-3. While evaporation from ocean surfaces is likely to increase with rising temperatures, it is unclear whether evapotranspiration from land surfaces could similarly increase, due to possible limitations imposed by soil moisture and vegetation physiology4. Observations suggest that groundwater (hereafter GW) has an important role in hydrological budgets and soil moisture variability in many regions, supplying moisture for evapotranspiration during dry seasons5, 6. Although modeling studies suggest that GW is often close enough to the surface to interact with the atmosphere7, 8, the soil water storage is often underestimated by land surface models. This is most likely due to neglecting the lateral movement of water from topographically higher altitudes to valley bottoms and its convergence close to the land surface, as well as the upward movement of water in the capillary fringe.The focus of this study is to understand where and when GW may significantly enhance the availability of soil water for evapotranspiration. We also quantified the potential contribution of GW to evapotranspiration in the areas where GW is a major supply. We used the global network of eddy covariance observations9 (FLUXNET) along with global modeled GW depth10 and GLEAM ET model estimates11 to address the current gap in modelling ET due to neglecting GW supply. Having identified areas where GW is tightly coupled with the atmosphere through evaporation processes, the study provides the basis to examine the "air conditioning effect" of GW and test the idea if GW enhances evaporation to the extent that leads to a cooler temperatures and wetter climates.

  20. Enhanced MRI in patients with facial palsy

    International Nuclear Information System (INIS)

    Yanagida, Masahiro; Kato, Tsutomu; Ushiro, Koichi; Kitajiri, Masanori; Yamashita, Toshio; Kumazawa, Tadami; Tanaka, Yoshimasa

    1991-01-01

    We performed Gd-DTPA-enhanced magnetic resonance imaging (MRI) examinations at several stages in 40 patients with peripheral facial nerve palsy (Bell's palsy and Ramsay-Hunt syndrome). In 38 of the 40 patients, one and more enhanced region could be seen in certain portion of the facial nerve in the temporal bone on the affected side, whereas no enhanced regions were seen on the intact side. Correlations between the timing of the MRI examination and the location of the enhanced regions were analysed. In all 6 patients examined by MRI within 5 days after the onset of facial nerve palsy, enhanced regions were present in the meatal portion. In 3 of the 8 patients (38%) examined by MRI 6 to 10 days after the onset of facial palsy, enhanced areas were seen in both the meatal and labyrinthine portions. In 8 of the 9 patients (89%) tested 11 to 20 days after the onset of palsy, the vertical portion was enhanced. In the 12 patients examined by MRI 21 to 40 days after the onset of facial nerve palsy, the meatal portion was not enhanced while the labyrinthine portion, the horizontal portion and the vertical portion were enhanced in 5 (42%), 8 (67%) and 11 (92%), respectively. Enhancement in the vertical portion was observed in all 5 patients examined more than 41 days after the onset of facial palsy. These results suggest that the central portion of the facial nerve in the temporal bone tends to be enhanced in the early stage of facial nerve palsy, while the peripheral portion is enhanced in the late stage. These changes of Gd-DTPA enhanced regions in the facial nerve may suggest dromic degeneration of the facial nerve in peripheral facial nerve palsy. (author)

  1. Detectability of hepatocellular carcinoma: comparison of Gd-DTPA-enhanced and SPIO-enhanced MR imaging

    International Nuclear Information System (INIS)

    Kwak, Hyo Sung; Lee, Jeong Min; Kim In Hwan; Kim, Chong Soo; Han, Hyeun Young; Yoon, Kwon ha; Shin, Kyung Sook

    2000-01-01

    To compare the detectability of hepatocellular carcinoma (HCC) using superparamagnetic iron oxide (SPIO)-enhanced T2-weighted turbo spin echo (TSE), SPIO-enhanced T2-weighted FISP, and dynamic Gd-DTPA-enhanced fast low-angle shot (FLASH) MR images. In order to assess their hepatic lesions, 25 patients (20 men and 5 women) with HCC were enrolled in an MR study in which both gadolinium and Spiro were used. Since the lesions were most conspicuous during the phase of dynamic arterial dominant phase of dynamic gadolinium-enhanced imaging, this was the phase used for analysis. Images were analyzed qualitatively and quantitatively, and to compare the diagnostic value of gadolinium-enhanced imaging with that of SPIO-enhanced imaging for the detection of HCCs, a receiver-operated characteristic curve was obtained. Qualitative analysis revealed a significantly higher percentage of signal loss and a higher liver-lesion contrast-to-noise ratio on SPIO-enhanced FISP imaging than on SPIO-enhanced T2-weighted TSE imaging (p less than 0.05). It also showed that the lesions were most clearly visible on SPIO-enhanced FISP imaging (and significantly so), followed by SPIO-enhanced T2-weighted TSE imaging, and dynamic gadolinium-enhanced imaging. Imaging artifacts were more prominent on SPIO-enhanced T2-weighted TSE than on SPIO-enhanced PISF imaging or dynamic gadolinium-enhanced imaging (p less than 0.05). According to ROC analysis, SPIO-enhanced T2-weighted turbo spin echo (TSE) or SPIO-enhanced FISP imaging achieved higher accuracy than did dynamic gadolinium-enhanced FLASH imaging (p less than 0.05). For the detection of hepatocellular carcinomas, SPIO-enhanced MR imaging is better than gadolinium-enhanced FLASH imaging

  2. Delta Relaxation Enhanced Magnetic Resonance

    Science.gov (United States)

    Alford, Jamu K.

    Generally speaking, targeted molecular imaging has always been difficult to perform with magnetic resonance. The difficulty does not arise with the magnetic resonance imaging (MRI) technique or equipment itself, but rather with the targeted contrast agents, which the method requires. Also referred to as activatable contrast agents, or MRI probes, targeted contrast agents are pharmaceuticals that will selectively bind to a particular biological (target) molecule. They are used to highlight a certain tissue or the difference between healthy and diseased tissue. Unfortunately, nearly all MRI probes are non-specific, causing localized increases in MR image intensity in both the unbound and target-bound states. Therefore, brightening in a conventional MRI image, following probe injection, does not positively indicate the presence of the target molecule. Herein, a novel method known as delta relaxation enhanced magnetic resonance (dreMR, pronounced "dreamer") is presented that utilizes variable magnetic field technology to produce image contrast related to the dependence of the sample's longitudinal relaxation rates upon the strength of the main magnetic field of the MRI scanner. Since only bound contrast agent shows significant magnetic field dependence, it is an indicator of the bound probe, which is in turn a marker for the target molecule. This work details the development of the dreMR method, focusing on the specialized hardware necessary to provide a clinical, static-field MRI the ability to modulate its main magnetic field throughout an MRI sequence. All modifications were performed in such a manner that the host MRI system was not degraded or permanently modified in any way. The three parts of this technology are: the insertable electromagnet, the power supply system and the control system. The insertable electromagnet modifies the magnetic field, the power system drives the electromagnet, and the control system generates the magnetic field waveform envelope and

  3. Cognitive enhancement. Effort of definition, and methods

    Directory of Open Access Journals (Sweden)

    Artur Gunia

    2015-12-01

    Full Text Available The idea of cognitive enhancement refers to multifaceted and interdisciplinary approach aimed at improving human mental processes. Cognitive enhancement is the amplification or extension of core mind capacities through improvement or augmentation of either internal or external information processing systems. This includes improvements of intelligence and attention, reinforcement of creativity and memory, or extension of perception range. The main feature of cognitive enhancement is voluntariness of use for overcoming natural mental limitations. This article is a synthesis of current trends in cognitive enhancement from the perspective of transhumanism. The article presents various definitions of cognitive enhancement, methods of cognitive enhancement (biotechnological methods, non-pharmacological methods, IT methods as well as challenges and questions concerning improving human mental processes.

  4. Comparative enhancing effects of electret with chemical enhancers on transdermal delivery of meloxicam in vitro

    International Nuclear Information System (INIS)

    Cui, L L; Hou, X M; Li, G D; Jiang, J; Liang, Y Y; Xin, X

    2008-01-01

    Electret offers enhancing effect in transdermal drug delivery for altering of the arrangement of lipid molecules in the stratum corneum, forming many transient permeable apertures and enhancing the transdermal drug delivery. In this paper, meloxicam patch formulations were developed to make the comparative study of transdermal drug delivery between electret and chemical enhancers. Patches were made into control, electret, chemical enhancer and electret with chemical enhancer ones, according to the preparation procedure. The electret combined with chemical enhancer patch was designed to probe the incorporation between electret and chemical enhancer in transdermal drug delivery. The meloxicam release from the patch was found to increase in order of blank, chemical enhancer, electret and electret with chemical enhancer patch, in general.

  5. DiseaseEnhancer: a resource of human disease-associated enhancer catalog.

    Science.gov (United States)

    Zhang, Guanxiong; Shi, Jian; Zhu, Shiwei; Lan, Yujia; Xu, Liwen; Yuan, Huating; Liao, Gaoming; Liu, Xiaoqin; Zhang, Yunpeng; Xiao, Yun; Li, Xia

    2018-01-04

    Large-scale sequencing studies discovered substantial genetic variants occurring in enhancers which regulate genes via long range chromatin interactions. Importantly, such variants could affect enhancer regulation by changing transcription factor bindings or enhancer hijacking, and in turn, make an essential contribution to disease progression. To facilitate better usage of published data and exploring enhancer deregulation in various human diseases, we created DiseaseEnhancer (http://biocc.hrbmu.edu.cn/DiseaseEnhancer/), a manually curated database for disease-associated enhancers. As of July 2017, DiseaseEnhancer includes 847 disease-associated enhancers in 143 human diseases. Database features include basic enhancer information (i.e. genomic location and target genes); disease types; associated variants on the enhancer and their mediated phenotypes (i.e. gain/loss of enhancer and the alterations of transcription factor bindings). We also include a feature on our website to export any query results into a file and download the full database. DiseaseEnhancer provides a promising avenue for researchers to facilitate the understanding of enhancer deregulation in disease pathogenesis, and identify new biomarkers for disease diagnosis and therapy. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  6. Gd-enhanced MR imaging of the herniated lumbar disc: patterns of enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Kwag, Hyon Joo; Choi, Hye Young; Kim, Hyae Young; Kim, Yoo Kyung; Kim, Ah Young; Chung, Eun Chul [College of Medicine, Ewah Womans University, Seoul (Korea, Republic of)

    1995-07-15

    The purpose of this study is to describe the patterns of enhancement of the herniated lumbar disc with Gd-DTPA enhanced MR imaging. Out of 65 patients, 103 lumbar discs diagnosed to be herniated by MR image were retrospectively analyzed. The MR imaging was performed with 1.5 T MR unit, using T1-and T2-weighted sagittal and axial spin echo techniques. Contrast-enhanced T1 weighted sagittal and axial images were performed after intravenous injection of Gadopentetate-dimeglumine(Magnevist, Shering) (0.1 mmol/kg). Contrast enhancement was seen in 66 cases(64%). Thirteen cases of bulging disc were not enhanced. Twenty-eight cases of protruded disc showed intraannular enchantment in 23 cases, peripheral linear and irregular enhancement in each of one case, and nonenhancement in three cases. Fifty-seven cases of extruded disc showed irregular enhancement in 14 cases, peripheral linear enhancement in 12 cases, peripheral ring enhancement in five cases and intraannular enhancement in five cases. All five cases of sequestered disc showed peripheral ring enhancement. Protruded discs show intraannular enhancement frequently and sequestered discs usually show peripheral ring enhancement. Enhanced MR imaging may be helpful to evaluate the type of herniated lumbar disc and relationship among disc material, nerve root and thecal sac.

  7. Enhancement patterns and pseudo-washout of hepatic haemangiomas on gadoxetate disodium-enhanced liver MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bohyun [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Ajou University School of Medicine, Department of Radiology, Suwon (Korea, Republic of); Byun, Jae Ho; Kim, Hyoung Jung; Won, Hyung Jin; Kim, So Yeon; Shin, Yong Moon; Kim, Pyo Nyun [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of)

    2016-01-15

    To compare the enhancement patterns and prevalence of pseudo-washout between rapidly and slowly enhancing hepatic haemangiomas on gadoxetate disodium-enhanced MRI in patients with chronic liver disease (CLD) and healthy liver (HL). On gadoxetate disodium-enhanced MRI, the extent of intralesional arterial enhancement >50 % and ≤50 % of lesions was defined as rapid and slow enhancement, respectively. The enhancement patterns and presence of pseudo-washout during the portal venous phase (PVP) and transitional phase (TP) of 74 hepatic haemangiomas were retrospectively evaluated in the CLD and HL groups. Sequential changes of signal-to-noise ratio (SNR) were measured in unenhanced phase, PVP and TP. Irrespective of hepatic health status, pseudo-washout in TP was significantly more common in the rapidly enhancing haemangiomas (p ≤ 0.026). In both groups, rapidly enhancing haemangiomas showed complete or progressive incomplete enhancement in PVP, which either lasted or transformed to pseudo-washout in TP, whereas slowly enhancing haemangiomas showed progressive incomplete enhancement in PVP and TP. SNR of hepatic parenchyma continued to rise until TP, whereas that of portal vein and haemangioma falls in TP. Regardless of CLD, pseudo-washout in TP was more common in rapidly than in slowly enhancing haemangiomas, with enhancement patterns differing in the two subgroups. (orig.)

  8. Enhancement patterns and pseudo-washout of hepatic haemangiomas on gadoxetate disodium-enhanced liver MRI

    International Nuclear Information System (INIS)

    Kim, Bohyun; Byun, Jae Ho; Kim, Hyoung Jung; Won, Hyung Jin; Kim, So Yeon; Shin, Yong Moon; Kim, Pyo Nyun

    2016-01-01

    To compare the enhancement patterns and prevalence of pseudo-washout between rapidly and slowly enhancing hepatic haemangiomas on gadoxetate disodium-enhanced MRI in patients with chronic liver disease (CLD) and healthy liver (HL). On gadoxetate disodium-enhanced MRI, the extent of intralesional arterial enhancement >50 % and ≤50 % of lesions was defined as rapid and slow enhancement, respectively. The enhancement patterns and presence of pseudo-washout during the portal venous phase (PVP) and transitional phase (TP) of 74 hepatic haemangiomas were retrospectively evaluated in the CLD and HL groups. Sequential changes of signal-to-noise ratio (SNR) were measured in unenhanced phase, PVP and TP. Irrespective of hepatic health status, pseudo-washout in TP was significantly more common in the rapidly enhancing haemangiomas (p ≤ 0.026). In both groups, rapidly enhancing haemangiomas showed complete or progressive incomplete enhancement in PVP, which either lasted or transformed to pseudo-washout in TP, whereas slowly enhancing haemangiomas showed progressive incomplete enhancement in PVP and TP. SNR of hepatic parenchyma continued to rise until TP, whereas that of portal vein and haemangioma falls in TP. Regardless of CLD, pseudo-washout in TP was more common in rapidly than in slowly enhancing haemangiomas, with enhancement patterns differing in the two subgroups. (orig.)

  9. Gd-enhanced MR imaging of the herniated lumbar disc: patterns of enhancement

    International Nuclear Information System (INIS)

    Kwag, Hyon Joo; Choi, Hye Young; Kim, Hyae Young; Kim, Yoo Kyung; Kim, Ah Young; Chung, Eun Chul

    1995-01-01

    The purpose of this study is to describe the patterns of enhancement of the herniated lumbar disc with Gd-DTPA enhanced MR imaging. Out of 65 patients, 103 lumbar discs diagnosed to be herniated by MR image were retrospectively analyzed. The MR imaging was performed with 1.5 T MR unit, using T1-and T2-weighted sagittal and axial spin echo techniques. Contrast-enhanced T1 weighted sagittal and axial images were performed after intravenous injection of Gadopentetate-dimeglumine(Magnevist, Shering) (0.1 mmol/kg). Contrast enhancement was seen in 66 cases(64%). Thirteen cases of bulging disc were not enhanced. Twenty-eight cases of protruded disc showed intraannular enchantment in 23 cases, peripheral linear and irregular enhancement in each of one case, and nonenhancement in three cases. Fifty-seven cases of extruded disc showed irregular enhancement in 14 cases, peripheral linear enhancement in 12 cases, peripheral ring enhancement in five cases and intraannular enhancement in five cases. All five cases of sequestered disc showed peripheral ring enhancement. Protruded discs show intraannular enhancement frequently and sequestered discs usually show peripheral ring enhancement. Enhanced MR imaging may be helpful to evaluate the type of herniated lumbar disc and relationship among disc material, nerve root and thecal sac

  10. Surface-enhanced Raman spectroscopy: nonlocal limitations

    DEFF Research Database (Denmark)

    Toscano, Giuseppe; Raza, S.; Xiao, Sanshui

    2012-01-01

    for our understanding of surface-enhanced Raman spectroscopy (SERS). The intrinsic length scale of the electron gas serves to smear out assumed field singularities, leaving the SERS enhancement factor finite, even for geometries with infinitely sharp features. For silver nanogroove structures, mimicked...... by periodic arrays of half-cylinders (up to 120 nm in radius), we find no enhancement factors exceeding 10 orders of magnitude (10(10)). (C) 2012 Optical Society of America...

  11. Surface-enhanced Raman spectroscopy: nonlocal limitations

    DEFF Research Database (Denmark)

    Toscano, Giuseppe; Raza, Søren; Xiao, Sanshui

    2012-01-01

    for our understanding of surface-enhanced Raman spectroscopy (SERS). The intrinsic length scale of the electron gas serves to smear out assumed field singularities, leaving the SERS enhancement factor finite, even for geometries with infinitely sharp features. For silver nanogroove structures, mimicked...... by periodic arrays of half-cylinders (up to 120 nm in radius), we find no enhancement factors exceeding 10 orders of magnitude (1010)....

  12. Arousal-Enhanced Location Memory for Pictures

    OpenAIRE

    Mather, Mara; Nesmith, Kathryn

    2008-01-01

    Four experiments revealed arousal-enhanced location memory for pictures. After an incidental encoding task, participants were more likely to remember the locations of positive and negative arousing pictures than the locations of non-arousing pictures, indicating better binding of location to picture. This arousal-enhanced binding effect did not have a cost for the binding of nearby pictures to their locations. Thus, arousal can enhance binding of an arousing picture’s content to its location ...

  13. Multispectral Image Enhancement Through Adaptive Wavelet Fusion

    Science.gov (United States)

    2016-09-14

    AFRL-AFOSR-UK-TR-2017-0005 Multispectral image enhancement through adaptive wavelet fusion Alexander Toet Nederlandse Organisatie voor Toegepast...image enhancement through adaptive wavelet fusion 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-15-1-0433 5c.  PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S...efficient. 15. SUBJECT TERMS adaptive wavelet fusion, Multispectral image enhancement, Multispectral image fusion, multiband image interpolation

  14. Contrast-enhanced sonography in pancreatic diseases

    Energy Technology Data Exchange (ETDEWEB)

    Rickes, Steffen [Department of Internal Medicine, AMEOS Hospital GmbH, Halberstadt (Germany); Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University, Magdeburg (Germany)], E-mail: rickes@medkl.salvator-kh.de; Rauh, Peter; Uhle, Christine; Ensberg, Daniel [Department of Internal Medicine, AMEOS Hospital GmbH, Halberstadt (Germany); Moenkemueller, Klaus; Malfertheiner, Peter [Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University, Magdeburg (Germany)

    2007-11-15

    Contrast-enhanced sonography is a widely available imaging modality for the diagnosis of pancreatic diseases. With this procedure, pancreatic tumours can be differentiated better. Furthermore, contrast-enhanced sonography produces good results in the staging of acute pancreatitis severity, especially in the detection of pancreatic necrosis. In this review article the value of contrast-enhanced sonography in the diagnosis of pancreatic diseases will be described and discussed.

  15. Enhancement of colposcopic image by sulphosalicylic acid.

    Directory of Open Access Journals (Sweden)

    Khilnani P

    1993-01-01

    Full Text Available Acetic acid is used conventionally for enhancement of the colposcopic image. We used sulphosalicylic acid instead of acetic acid in 50 normal cases. The normal appearance was enhanced in all cases. The image was also enhanced in 70% cases of cervical intraepithelial neoplasia and 90% cases of cervical condyloma accuminata. The image was not inferior to that with acetic acid in any of the cases.

  16. Enhanced safeguards via solution monitoring

    International Nuclear Information System (INIS)

    Burr, T.; Wangen, L.

    1996-09-01

    Solution monitoring is defined as the essentially continuous monitoring of solution level, density, and temperature in all tanks in the process that contain, or could contain, safeguards-significant quantities of nuclear material. This report describes some of the enhancements that solution monitoring could make to international safeguards. The focus is on the quantifiable benefits of solution monitoring, but qualitatively, solution monitoring can be viewed as a form of surveillance. Quantitatively, solution monitoring can in some cases improve diversion detection probability. For example, the authors show that under certain assumptions, solution monitoring can be used to reduce the standard deviation of the annual material balance, σ MB , from approximately 17 kg to approximately 4 kg. Such reduction in σ MB will not always be possible, as they discuss. However, in all cases, solution monitoring would provide assurance that the measurement error models are adequate so that one has confidence in his estimate of σ MB . Some of the results in this report were generated using data that were simulated with prototype solution monitoring software that they are developing. An accompanying document describes that software

  17. Does facial resemblance enhance cooperation?

    Directory of Open Access Journals (Sweden)

    Trang Giang

    Full Text Available Facial self-resemblance has been proposed to serve as a kinship cue that facilitates cooperation between kin. In the present study, facial resemblance was manipulated by morphing stimulus faces with the participants' own faces or control faces (resulting in self-resemblant or other-resemblant composite faces. A norming study showed that the perceived degree of kinship was higher for the participants and the self-resemblant composite faces than for actual first-degree relatives. Effects of facial self-resemblance on trust and cooperation were tested in a paradigm that has proven to be sensitive to facial trustworthiness, facial likability, and facial expression. First, participants played a cooperation game in which the composite faces were shown. Then, likability ratings were assessed. In a source memory test, participants were required to identify old and new faces, and were asked to remember whether the faces belonged to cooperators or cheaters in the cooperation game. Old-new recognition was enhanced for self-resemblant faces in comparison to other-resemblant faces. However, facial self-resemblance had no effects on the degree of cooperation in the cooperation game, on the emotional evaluation of the faces as reflected in the likability judgments, and on the expectation that a face belonged to a cooperator rather than to a cheater. Therefore, the present results are clearly inconsistent with the assumption of an evolved kin recognition module built into the human face recognition system.

  18. Image enhancement for astronomical scenes

    Science.gov (United States)

    Lucas, Jacob; Calef, Brandoch; Knox, Keith

    2013-09-01

    Telescope images of astronomical objects and man-made satellites are frequently characterized by high dynamic range and low SNR. We consider the problem of how to enhance these images, with the aim of making them visually useful rather than radiometrically accurate. Standard contrast and histogram adjustment tends to strongly amplify noise in dark regions of the image. Sophisticated techniques have been developed to address this problem in the context of natural scenes. However, these techniques often misbehave when confronted with low-SNR scenes that are also mostly empty space. We compare two classes of algorithms: contrast-limited adaptive histogram equalization, which achieves spatial localization via a tiling of the image, and gradient-domain techniques, which perform localized contrast adjustment by non-linearly remapping the gradient of the image in a content-dependent manner. We extend these to include a priori knowledge of SNR and the processing (e.g. deconvolution) that was applied in the preparation of the image. The methods will be illustrated with images of satellites from a ground-based telescope.

  19. Facebook enhances antidepressant pharmacotherapy effects.

    Science.gov (United States)

    Mota Pereira, Jorge

    2014-01-01

    Treatment-resistant major depressive disorder (TR-MDD) is a complex condition, with very low remission rates. In recent years some studies have been conducted on the implementation of cognitive behavioral therapy and psychodynamic psychotherapy interventions via the Internet to MDD patients, and results have been promising. However, there have been no studies in patients with TR-MDD nor with the use of Facebook with the psychiatrist as "friend." 60 TR-MDD patients were randomized to one of three groups: Facebook group with psychiatrist as "friend," Facebook group without psychiatrist as "friend," and control group (no Facebook use). Both Facebook groups spent at least 1 hour/day on Facebook, 7 days/week, during the 3 months. All patients maintained their usual pharmacotherapy. All participants were evaluated at baseline and at 1, 2, and 3 months for depressive symptoms using HAD17 and BDI-II. Results show that both Facebook groups had a decrease on HADM17 and BDI-II scores as well as higher remission and response rates than the control group, with better results if the psychiatrist was a "friend" on Facebook. Therefore, in TR-MDD, Facebook can be used as an effective enhancement therapy, adjuvant to pharmacological therapy with regular consultations, especially if the psychiatrist is the patient's online "friend."

  20. An enhanced tokamak startup model

    Science.gov (United States)

    Goswami, Rajiv; Artaud, Jean-François

    2017-01-01

    The startup of tokamaks has been examined in the past in varying degree of detail. This phase typically involves the burnthrough of impurities and the subsequent rampup of plasma current. A zero-dimensional (0D) model is most widely used where the time evolution of volume averaged quantities determines the detailed balance between the input and loss of particle and power. But, being a 0D setup, these studies do not take into consideration the co-evolution of plasma size and shape, and instead assume an unchanging minor and major radius. However, it is known that the plasma position and its minor radius can change appreciably as the plasma evolves in time to fill in the entire available volume. In this paper, an enhanced model for the tokamak startup is introduced, which for the first time takes into account the evolution of plasma geometry during this brief but highly dynamic period by including realistic one-dimensional (1D) effects within the broad 0D framework. In addition the effect of runaway electrons (REs) has also been incorporated. The paper demonstrates that the inclusion of plasma cross section evolution in conjunction with REs plays an important role in the formation and development of tokamak startup. The model is benchmarked against experimental results from ADITYA tokamak.

  1. Biopolymeric nanocomposites with enhanced interphases.

    Science.gov (United States)

    Yin, Yi; Hu, Kesong; Grant, Anise M; Zhang, Yuhong; Tsukruk, Vladimir V

    2015-10-06

    Ultrathin and robust nanocomposite membranes were fabricated by incorporating graphene oxide (GO) sheets into a silk fibroin (SF) matrix by a dynamic spin-assisted layer-by-layer assembly (dSA-LbL). We observed that in contrast to traditional SA-LbL reported earlier fast solution removal during dropping of solution on constantly spinning substrates resulted in largely unfolded biomacromolecules with enhanced surface interactions and suppressed nanofibril formation. The resulting laminated nanocomposites possess outstanding mechanical properties, significantly exceeding those previously reported for conventional LbL films with similar composition. The tensile modulus reached extremely high values of 170 GPa, which have never been reported for graphene oxide-based nanocomposites, the ultimate strength was close to 300 MPa, and the toughness was above 3.4 MJ m(-3). The failure modes observed for these membranes suggested the self-reinforcing mechanism of adjacent graphene oxide sheets with strong 2 nm thick silk interphase composed mostly from individual backbones. This interphase reinforcement leads to the effective load transfer between the graphene oxide components in reinforced laminated nanocomposite materials with excellent mechanical strength that surpasses those known today for conventional flexible laminated carbon nanocomposites from graphene oxide and biopolymer components.

  2. Enhanced decision making through neuroscience

    Science.gov (United States)

    Szu, Harold; Jung, TP; Makeig, Scott

    2012-06-01

    We propose to enhance the decision making of pilot, co-pilot teams, over a range of vehicle platforms, with the aid of neuroscience. The goal is to optimize this collaborative decision making interplay in time-critical, stressful situations. We will research and measure human facial expressions, personality typing, and brainwave measurements to help answer questions related to optimum decision-making in group situations. Further, we propose to examine the nature of intuition in this decision making process. The brainwave measurements will be facilitated by a University of California, San Diego (UCSD) developed wireless Electroencephalography (EEG) sensing cap. We propose to measure brainwaves covering the whole head area with an electrode density of N=256, and yet keep within the limiting wireless bandwidth capability of m=32 readouts. This is possible because solving Independent Component Analysis (ICA) and finding the hidden brainwave sources allow us to concentrate selective measurements with an organized sparse source -->s sensing matrix [Φs], rather than the traditional purely random compressive sensing (CS) matrix[Φ].

  3. Carbon-enhanced VRLA batteries.

    Energy Technology Data Exchange (ETDEWEB)

    Enos, David George; Hund, Thomas D.; Shane, Rod (East Penn Manufacturing, Lyon Station, PA)

    2010-10-01

    The addition of certain forms of carbon to the negative plate in valve regulated lead acid (VRLA) batteries has been demonstrated to increase the cycle life of such batteries by an order of magnitude or more under high-rate, partial-state-of-charge operation. Such performance will provide a significant impact, and in some cases it will be an enabling feature for applications including hybrid electric vehicles, utility ancillary regulation services, wind farm energy smoothing, and solar photovoltaic energy smoothing. There is a critical need to understnd how the carbon interacts with the negative plate and achieves the aforementioned benefits at a fundamental level. Such an understanding will not only enable the performance of such batteries to be optimzied, but also to explore the feasibility of applying this technology to other battery chemistries. In partnership with the East Penn Manufacturing, Sandia will investigate the electrochemical function of the carbon and possibly identify improvements to its anti-sulfation properties. Shiomi, et al. (1997) discovered that the addition of carbon to the negative active material (NAM) substantially reduced PbSO{sub 4} accumulation in high rate, partial state of charge (HRPSoC) cycling applications. This improved performance with a minimal cost. Cycling applications that were uneconomical for traditional VRLA batteries are viable for the carbon enhanced VRLA. The overall goal of this work is to quantitatively define the role that carbon plays in the electrochemistry of a VRLA battery.

  4. Coherently Enhanced Wireless Power Transfer

    Science.gov (United States)

    Krasnok, Alex; Baranov, Denis G.; Generalov, Andrey; Li, Sergey; Alù, Andrea

    2018-04-01

    Extraction of electromagnetic energy by an antenna from impinging external radiation is at the basis of wireless communications and wireless power transfer (WPT). The maximum of transferred energy is ensured when the antenna is conjugately matched, i.e., when it is resonant and it has an equal coupling with free space and its load. This condition, however, can be easily affected by changes in the environment, preventing optimal operation of a WPT system. Here, we introduce the concept of coherently enhanced WPT that allows us to bypass this difficulty and achieve dynamic control of power transfer. The approach relies on coherent excitation of the waveguide connected to the antenna load with a backward propagating signal of specific amplitude and phase. This signal creates a suitable interference pattern at the load resulting in a modification of the local wave impedance, which in turn enables conjugate matching and a largely increased amount of extracted energy. We develop a simple theoretical model describing this concept, demonstrate it with full-wave numerical simulations for the canonical example of a dipole antenna, and verify experimentally in both near-field and far-field regimes.

  5. Enhanced Model for Fast Ignition

    Energy Technology Data Exchange (ETDEWEB)

    Mason, Rodney J. [Research Applications Corporation, Los Alamos, NM (United States)

    2010-10-12

    Laser Fusion is a prime candidate for alternate energy production, capable of serving a major portion of the nation's energy needs, once fusion fuel can be readily ignited. Fast Ignition may well speed achievement of this goal, by reducing net demands on laser pulse energy and timing precision. However, Fast Ignition has presented a major challenge to modeling. This project has enhanced the computer code ePLAS for the simulation of the many specialized phenomena, which arise with Fast Ignition. The improved code has helped researchers to understand better the consequences of laser absorption, energy transport, and laser target hydrodynamics. ePLAS uses efficient implicit methods to acquire solutions for the electromagnetic fields that govern the accelerations of electrons and ions in targets. In many cases, the code implements fluid modeling for these components. These combined features, "implicitness and fluid modeling," can greatly facilitate calculations, permitting the rapid scoping and evaluation of experiments. ePLAS can be used on PCs, Macs and Linux machines, providing researchers and students with rapid results. This project has improved the treatment of electromagnetics, hydrodynamics, and atomic physics in the code. It has simplified output graphics, and provided new input that avoids the need for source code access by users. The improved code can now aid university, business and national laboratory users in pursuit of an early path to success with Fast Ignition.

  6. Narrowband Compton Scattering Yield Enhancement

    Science.gov (United States)

    Rykovanov, Sergey; Seipt, Daniel; Kharin, Vasily

    2017-10-01

    Compton Scattering (CS) of laser light off high-energy electrons is a well-established source of X- and gamma-rays for applications in medicine, biology, nuclear and material sciences. Main advantage of CS photon sources is the possibility to generate narrow spectra as opposed to a broad continuum obtained when utilizing Bremsstrahlung. However, due to the low cross-section of the linear process, the total photon yield is quite low. The most straightforward way to increase the number of photon-electron beam scattering events is to increase the laser pulse intensity at the interaction point by harder focusing. This leads to an unfortunate consequence. Increase in the laser pulse normalized amplitude a0, leads to additional ponderomotive spectrum broadening of the scattered radiation. The ponderomotive broadening is caused by the v × B force, which slows the electron down near the peak of the laser pulse where the intensity is high, and can be neglected near the wings of the pulse, where the intensity is low. We show that laser pulse chirping, both nonlinear (laser pulse frequency ''following'' the envelope of the pulse) and linear, leads to compensation of the ponderomotive broadening and considerably enhances the yield of the nonlinear Compton sources. Work supported by the Helmholtz Association via Helmholtz Young Investigators Grant (VH-NG-1037).

  7. Enhancing professionalism at GPU nuclear

    International Nuclear Information System (INIS)

    Coe, R.P.; Landy, F.J.

    1991-01-01

    Late in 1988, GPU Nuclear embarked on a major program aimed at enhancing Professionalism at its Oyster Creek and Three Mile Island Nuclear Generating Stations. The program was also to include its Corporate Headquarters in Parsippany, New Jersey. The overall program was to take several directions which included on-site degree programs, a sabbatical leave-type program for personnel to finish college degrees, advanced technical training for licensed staff, career progression for SROs and expanded teamwork and leadership training for control room crews. The largest portion of this initiative was the development and delivery of professionalism training to the nearly two thousand people at both sites. Three primary philosophies guided the development of the program. Employees as Experts: First, GPU Nuclear employees were considered to be the most valuable source of information for designing a Professionalism program because it is these individuals who are sensitive to the issues encountered in the workplace. Realism: The second philosophy guiding this effort was that the program must be grounded in real life challenges that employees face and must address. Active Learning: The third guiding philosophy was that, in order to have any real impact on the way employees think about professionalism, the program must utilize active rather than passive learning techniques

  8. Dural enhancement with primary calvarial lesions.

    Science.gov (United States)

    Arana, E; Martí-Bonmatí, L; Ricart, V; Pérez-Ebrí, M

    2004-11-01

    The purpose of this study was to relate the pathological and imaging features of dural enhancement and meningeal sign ("dural tail") on contrast-enhanced T1-weighted magnetic resonance (MR) images from patients with primary calvarial lesions as well to assess the accuracy of MR imaging in predicting dural invasion. Thirty-two calvarial tumors studied with contrast-enhanced MR imaging and histopathological examination of the dural specimens were reviewed. Sixteen patients presented dural enhancement, eight with tumor invasion. Tumoral invasion of the dura was observed in one case without enhancement. Malignant lesions showed enhanced dura more commonly than benign lesions (P=0.02). Nodular and discontinuous dural enhancement was statistically associated with dural invasion (P=0.05). Dural tail did not show a specific pathological association. Meningeal enhancement is a nonspecific reaction to calvarial lesions unless nodular and discontinuous. False-negative and -positive cases of dural invasion imply some limitation of contrast-enhanced MR imaging in predicting dural invasion by calvarial neoplasms.

  9. Electroluminescence Efficiency Enhancement using Metal Nanoparticles

    National Research Council Canada - National Science Library

    Soref, Richard A; Khurgin, J. B; Sun, G

    2008-01-01

    We apply the "effective mode volume" theory to evaluate enhancement of the electroluminescence efficiency of semiconductor emitters placed in the vicinity of isolated metal nanoparticles and their arrays...

  10. Patterns of uterine enhancement with helical CT

    International Nuclear Information System (INIS)

    Kaur, H.; Loyer, E.M.; Charnsangavej, C.; Minami, M.

    1998-01-01

    Objective: The purpose of this study was to evaluate the enhancement characteristics of the normal uterine body and cervix using dynamic contrast-enhanced helical CT. Methods: Thirty-eight women scheduled for pelvic CT for non-gynecologic malignancies underwent dynamic contrast-enhanced helical CT of the pelvis. Data acquisition was during the arterial phase (30-45 s after the start of injection), the parenchymal phase (90-120 s after the start of injection), and delayed phase (3-9 min after the start of injection). The images were evaluated by four radiologists for the pattern of myometrial and cervical enhancement. Correlation was made with the age and menstrual status of the patients. Results: In the uterine body, three types of enhancement were observed. Type 1 enhancement, seen in 16 patients (42%), was characterized by the visualization of a subendometrial zone of enhancement, 30-120 s after the start of injection. Eight of these patients also showed an enhancing zone in the outer myometrium. Both zones were transitory, and in all cases, the uterus became homogeneous in the delayed phase. This pattern was seen predominantly in premenopausal women with a mean age of 34 years. Type 2 enhancement, seen in 17 cases (45%), was defined by the absence of subendometrial enhancement in the early phase. Enhancement was either diffuse from the outset or originated in the outer myometrium. This pattern was seen nearly equally in premenopausal and postmenopausal women with a mean age of 40 years. Type 3 enhancement was seen in five postmenopausal patients (13%) with a mean age of 53 years and was characterized by faint diffuse enhancement. In the cervix, a zonal pattern of enhancement defining inner and outer stroma was seen in 23 patients (61%). Fifteen patients were premenopausal and eight were postmenopausal. Conclusion: In this study, we have shown a transitory zonal distribution of the contrast in the myometrium and cervix using dynamic contrast-enhanced helical CT

  11. Enhancer-derived RNA: A Primer.

    Science.gov (United States)

    Liu, Feng

    2017-06-01

    Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome. The correlation between eRNA production and enhancer activity has stimulated studies on the potential role of eRNAs in transcriptional regulation. Additionally, eRNA has also served as a marker for global identification of enhancers. Here I review the brief history and fascinating properties of eRNAs. Copyright © 2017 The Author. Production and hosting by Elsevier B.V. All rights reserved.

  12. Enhancer-derived RNA: A Primer

    Directory of Open Access Journals (Sweden)

    Feng Liu

    2017-06-01

    Full Text Available Enhancer-derived RNAs (eRNAs are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome. The correlation between eRNA production and enhancer activity has stimulated studies on the potential role of eRNAs in transcriptional regulation. Additionally, eRNA has also served as a marker for global identification of enhancers. Here I review the brief history and fascinating properties of eRNAs.

  13. Robotically enhanced rubber hand illusion.

    Science.gov (United States)

    Arata, Jumpei; Hattori, Masashi; Ichikawa, Shohei; Sakaguchi, Masamichi

    2014-01-01

    The rubber hand illusion is a well-known multisensory illusion. In brief, watching a rubber hand being stroked by a paintbrush while one's own unseen hand is synchronously stroked causes the rubber hand to be attributed to one's own body and to "feel like it's my hand." The rubber hand illusion is thought to be triggered by the synchronized tactile stimulation of both the subject's hand and the fake hand. To extend the conventional rubber hand illusion, we introduce robotic technology in the form of a master-slave telemanipulator. The developed one degree-of-freedom master-slave system consists of an exoskeleton master equipped with an optical encoder that is worn on the subject's index finger and a motor-actuated index finger on the rubber hand, which allows the subject to perform unilateral telemanipulation. The moving rubber hand illusion has been studied by several researchers in the past with mechanically connected rigs between the subject's body and the fake limb. The robotic instruments let us investigate the moving rubber hand illusion with less constraints, thus behaving closer to the classic rubber hand illusion. In addition, the temporal delay between the body and the fake limb can be precisely manipulated. The experimental results revealed that the robotic instruments significantly enhance the rubber hand illusion. The time delay is significantly correlated with the effect of the multisensory illusion, and the effect significantly decreased at time delays over 100 ms. These findings can potentially contribute to the investigations of neural mechanisms in the field of neuroscience and of master-slave systems in the field of robotics.

  14. Protocolized hyperventilation enhances electroconvulsive therapy.

    Science.gov (United States)

    de Arriba-Arnau, Aida; Dalmau, Antonia; Soria, Virginia; Salvat-Pujol, Neus; Ribes, Carmina; Sánchez-Allueva, Ana; Menchón, José Manuel; Urretavizcaya, Mikel

    2017-08-01

    Hyperventilation is recommended in electroconvulsive therapy (ECT) to enhance seizures and to increase patients' safety. However, more evidence is needed regarding its effects and the optimum method of application. This prospective study involving 21 subjects compared two procedures, protocolized hyperventilation (PHV) and hyperventilation as usual (HVau), applied to the same patient in two consecutive sessions. Transcutaneous partial pressure of carbon dioxide (TcPCO 2 ) was measured throughout all sessions. Ventilation parameters, hemodynamic measures, seizure characteristics, and side effects were also explored. PHV resulted in lower TcPCO 2 after hyperventilation (p=.008) and over the whole session (p=.035). The lowest TcPCO 2 was achieved after voluntary hyperventilation. Changes in TcPCO 2 from baseline showed differences between HVau and PHV at each session time-point (all p<.05). Between- and within-subjects factors were statistically significant in a general linear model. Seizure duration was greater in PHV sessions (p=.028), without differences in other seizure quality parameters or adverse effects. Correlations were found between hypocapnia induction and seizure quality indexes. Secondary outcomes could be underpowered. PHV produces hypocapnia before the stimulus, modifies patients' TcPCO 2 values throughout the ECT session and lengthens seizure duration. Voluntary hyperventilation is the most important part of the PHV procedure with respect to achieving hypocapnia. A specific ventilation approach, CO 2 quantification and monitoring may be advisable in ECT. PHV is easy to apply in daily clinical practice and does not imply added costs. Ventilation management has promising effects in terms of optimizing ECT technique. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Oscillatory Reinstatement Enhances Declarative Memory.

    Science.gov (United States)

    Javadi, Amir-Homayoun; Glen, James C; Halkiopoulos, Sara; Schulz, Mei; Spiers, Hugo J

    2017-10-11

    Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performance in a number of studies. Recent models have argued that neural oscillations may be crucial to reinstatement for successful memory retrieval. However, to date, no causal evidence has been provided to support this theory, nor has the impact of oscillatory electrical brain stimulation during encoding and retrieval been assessed. To explore this we used transcranial alternating current stimulation over the left dorsolateral prefrontal cortex of human participants [ n = 70, 45 females; age mean (SD) = 22.12 (2.16)] during a declarative memory task. Participants received either the same frequency during encoding and retrieval (60-60 or 90-90 Hz) or different frequencies (60-90 or 90-60 Hz). When frequencies matched there was a significant memory improvement (at both 60 and 90 Hz) relative to sham stimulation. No improvement occurred when frequencies mismatched. Our results provide support for the role of oscillatory reinstatement in memory retrieval. SIGNIFICANCE STATEMENT Recent neurobiological models of memory have argued that large-scale neural oscillations are reinstated to support successful memory retrieval. Here we used transcranial alternating current stimulation (tACS) to test these models. tACS has recently been shown to induce neural oscillations at the frequency stimulated. We stimulated over the left dorsolateral prefrontal cortex during a declarative memory task involving learning a set of words. We found that tACS applied at the same frequency during encoding and retrieval enhances memory. We also find no difference between the two applied frequencies. Thus our results are consistent with the proposal that reinstatement of neural oscillations during retrieval

  16. Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation

    Directory of Open Access Journals (Sweden)

    Hongjun Chen

    2017-06-01

    Full Text Available Long non-coding RNAs (lncRNAs have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs. The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.

  17. Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Integrity

    Science.gov (United States)

    Rothschild, Gerson; Basu, Uttiya

    2017-01-01

    Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer and/or promoter sequences. Here, we expand on current concepts to discuss enhancer RNAs and enhancer transcription, and how enhancer transcription influences genomic organization and integrity. PMID:28087167

  18. Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability.

    Science.gov (United States)

    Rothschild, Gerson; Basu, Uttiya

    2017-02-01

    Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer and/or promoter sequences. Here, we expand on current concepts to discuss enhancer RNAs and enhancer transcription, and how enhancer transcription influences genomic organization and integrity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Enhancer evolution across 20 mammalian species

    DEFF Research Database (Denmark)

    Villar, Diego; Berthelot, Camille; Aldridge, Sarah

    2015-01-01

    by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements...

  20. 23 CFR 710.511 - Transportation enhancements.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Transportation enhancements. 710.511 Section 710.511 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT RIGHT-OF-WAY AND REAL ESTATE Property Acquisition Alternatives § 710.511 Transportation enhancements. (a...

  1. Learner Ownership of Technology-Enhanced Learning

    Science.gov (United States)

    Dommett, Eleanor J.

    2018-01-01

    Purpose: This paper aims to examine the different ways in which learners may have ownership over technology-enhanced learning by reflecting on technical, legal and psychological ownership. Design/methodology/approach: The paper uses a variety of examples of technology-enhanced learning ranging from open-source software to cloud storage to discuss…

  2. Surfactant enhanced non-classical extraction

    International Nuclear Information System (INIS)

    Szymanowski, J.

    1999-01-01

    Surfactant enhanced non-classical extractions are presented and discussed. They include micellar enhanced ultrafiltration and cloud point extraction. The ideas of the processes are given and the main features are presented. They are compared to the classical solvent extraction. The fundamental of micellar solutions and their solubilization abilities are also discussed. (author)

  3. Leadership Enhancement of Rural Women. | Patwardhan | Gender ...

    African Journals Online (AJOL)

    The study aimed at developing a training program for enhancement of women leadership and executing and evaluating its effect. The Enhancement of Women Leadership Program (EWLP) was developed, which consists of five broad dimensions as Nurturing Intelligence, Self Development, Developing Leadership Skills, ...

  4. Sickle erythrocytes enhance phenylephrine and histamine ...

    African Journals Online (AJOL)

    Sickle erythrocytes enhance phenylephrine and histamine contractions of isolated rabbit carotid arteries. ... enhancement of histamine contractions, compared with phenylephrine (in AS and SS), suggests a possible role for histamine in the increased vascular tone and vaso-occlusive crisis in sickle cell disease.

  5. Treatments that enhance physical properties of wood

    Science.gov (United States)

    Roger M. Rowell; Peggy Konkol

    1987-01-01

    This paper was prepared for anyone who wants to know more about enhancing wood’s physical properties, from the amateur wood carver to the president of a forest products company. The authors describe chemical and physical treatments of wood that enhance the strength, stiffness, water repellency, and stability of wood. Five types of treatments are described: 1. water-...

  6. Arousal-Enhanced Location Memory for Pictures

    Science.gov (United States)

    Mather, Mara; Nesmith, Kathryn

    2008-01-01

    Four experiments revealed arousal-enhanced location memory for pictures. After an incidental encoding task, participants were more likely to remember the locations of positive and negative arousing pictures than the locations of non-arousing pictures, indicating better binding of location to picture. This arousal-enhanced binding effect did not…

  7. Recommender Systems in Technology Enhanced Learning

    NARCIS (Netherlands)

    Manouselis, Nikos; Drachsler, Hendrik; Verbert, Katrien; Santos, Olga

    2010-01-01

    Manouselis, N., Drachsler, H., Verbert, K., & Santos, C. S. (Eds.) (2010). Recommender System in Technology Enhanced Learning. Elsevier Procedia Computer Science: Volume 1, Issue 2. Proceedings of the 1st Workshop on Recommender Systems for Technology Enhanced Learning (RecSysTEL). September, 29-30,

  8. Enhanced living environments from models to technologies

    CERN Document Server

    Dobre, Ciprian; Ganchev, Ivan; Garcia, Nuno; Goleva, Rossitza Ivanova

    2017-01-01

    Enhanced living environments employ information and communications technologies to support true ambient assisted living for people with disabilities. This book provides an overview of today's architectures, techniques, protocols, components, and cloud-based solutions related to ambient assisted living and enhanced living environments.

  9. College Enhancement Strategies and Socioeconomic Inequality

    Science.gov (United States)

    Wolniak, Gregory C.; Wells, Ryan S.; Engberg, Mark E.; Manly, Catherine A.

    2016-01-01

    The study provides new information on the relationships between students' socioeconomic backgrounds, utilization of college enhancement strategies, and subsequent 4-year college enrollment. Enhancement strategies represent student behaviors used to bolster the competitiveness of a college application, such as Advanced Placement exams and a variety…

  10. Input Enhancement and L2 Question Formation.

    Science.gov (United States)

    White, Lydia; And Others

    1991-01-01

    Investigated the extent to which form-focused instruction and corrective feedback (i.e., "input enhancement"), provided within a primarily communicative program, contribute to learners' accuracy in question formation. Study results are interpreted as evidence that input enhancement can bring about genuine changes in learners' interlanguage…

  11. Self-Enhancing Illusions among Chinese Schoolchildren.

    Science.gov (United States)

    Falbo, Toni; And Others

    1997-01-01

    Demonstrates that East Asian children (EAC) do engage in some forms of self-enhancing illusions. Responses from 4,000 elementary school students reveal EACs see themselves as possessing more positive attributes than others. Variations in self-enhancing illusions were found for age, gender, and region of residence. Results are discussed in terms of…

  12. Enhancement of Solubility and Bioavailability of Candesartan ...

    African Journals Online (AJOL)

    Purpose: To enhance the otherwise poor solubility and bioavailability of candesartan cilexetil (CDS). Methods: This study involved enhancing drug solubility by various solid dispersion (SD) methods. The drug: carrier ratio was as follows: for urea (1:2, 1:4 and 1:6; for polyethylene glycol 6000 (PEG, 1:2 and 1:4, 1:8); and ...

  13. Enhanced Controlled Transdermal Delivery of Torasemide Using ...

    African Journals Online (AJOL)

    Purpose: To develop an ethylene-vinyl acetate (EVA) matrix system containing a permeation enhancer for enhanced transdermal delivery of torasemide. Methods: The solubility of torasemide was studied at various volume fraction of polyethylene glycol (PEG) 400. The effect of drug concentration was tested at 1.0, 2.0 and ...

  14. Conceptual and practical problems of moral enhancement.

    Science.gov (United States)

    Beck, Birgit

    2015-05-01

    Recently, the debate on human enhancement has shifted from familiar topics like cognitive enhancement and mood enhancement to a new and - to no one's surprise - controversial subject, namely moral enhancement. Some proponents from the transhumanist camp allude to the 'urgent need' of improving the moral conduct of humankind in the face of ever growing technological progress and the substantial dangers entailed in this enterprise. Other thinkers express more sceptical views about this proposal. As the debate has revealed so far, there is no shared opinion among philosophers (or scientists) about the meaning, prospects, and ethical evaluation of moral enhancement. In this article I will address several conceptual and practical problems of this issue, in order to encourage discussion about the prospects of (thinking about) moral enhancement in the future. My assumption is that (i) for the short term, there is little chance of arriving at an agreement on the proper understanding of morality and the appropriateness of one single (meta-)ethical theory; (ii) apart from this, there are further philosophical puzzles loosely referred to in the debate which add to theoretical confusion; and (iii) even if these conceptual problems could be solved, there are still practical problems to be smoothed out if moral enhancement is ever to gain relevance apart from merely theoretical interest. My tentative conclusion, therefore, will be that moral enhancement is not very likely to be made sense of - let alone realized - in the medium-term future. © 2014 John Wiley & Sons Ltd.

  15. Enhancement of retronasal odors by taste.

    Science.gov (United States)

    Green, Barry G; Nachtigal, Danielle; Hammond, Samuel; Lim, Juyun

    2012-01-01

    Psychophysical studies of interactions between retronasal olfaction and taste have focused most often on the enhancement of tastes by odors, which has been attributed primarily to a response bias (i.e., halo dumping). Based upon preliminary evidence that retronasal odors could also be enhanced by taste, the present study measured both forms of enhancement using appropriate response categories. In the first experiment, subjects rated taste ("sweet," "sour," "salty," and "bitter") and odor ("other") intensity for aqueous samples of 3 tastants (sucrose, NaCl, and citric acid) and 3 odorants (vanillin, citral, and furaneol), both alone and in taste-odor mixtures. The results showed that sucrose, but not the other taste stimuli, significantly increased the perceived intensity of all 3 odors. Enhancement of tastes by odors was inconsistent and generally weaker than enhancement of odors by sucrose. A second experiment used a flavored beverage and a custard dessert to test whether the findings from the first experiment would hold for the perception of actual foods. Adding sucrose significantly enhanced the intensity of "cherry" and "vanilla" flavors, whereas adding vanillin did not significantly enhance the intensity of sweetness. It is proposed that enhancement of retronasal odors by a sweet stimulus results from an adaptive sensory mechanism that serves to increase the salience of the flavor of nutritive foods. © The Author 2011. Published by Oxford University Press. All rights reserved.

  16. Automated image enhancement using power law transformations

    Indian Academy of Sciences (India)

    Automatically enhancing contrast of an image has been a challenging task since the digital image can represent variety of scene types. Trifonov et al (2001) performed automatic contrast enhancement by automatically determining the measure of central tendency of the brightness histogram of an image and shifting and ...

  17. Hopping Conductivity Enhanced by Microwave Radiation

    International Nuclear Information System (INIS)

    Ovadyahu, Z

    2012-01-01

    Hopping conductivity is enhanced when exposed to microwave (MW) fields. Data taken on several Anderson-localized systems and granular-aluminium are presented to illustrate the generality of the phenomenon. It is suggested that the effect is due to a field-enhanced hopping, which is the ac version of a non-ohmic effect familiar from studies in the dc transport regime.

  18. Speech enhancement on smartphone voice recording

    International Nuclear Information System (INIS)

    Atmaja, Bagus Tris; Farid, Mifta Nur; Arifianto, Dhany

    2016-01-01

    Speech enhancement is challenging task in audio signal processing to enhance the quality of targeted speech signal while suppress other noises. In the beginning, the speech enhancement algorithm growth rapidly from spectral subtraction, Wiener filtering, spectral amplitude MMSE estimator to Non-negative Matrix Factorization (NMF). Smartphone as revolutionary device now is being used in all aspect of life including journalism; personally and professionally. Although many smartphones have two microphones (main and rear) the only main microphone is widely used for voice recording. This is why the NMF algorithm widely used for this purpose of speech enhancement. This paper evaluate speech enhancement on smartphone voice recording by using some algorithms mentioned previously. We also extend the NMF algorithm to Kulback-Leibler NMF with supervised separation. The last algorithm shows improved result compared to others by spectrogram and PESQ score evaluation. (paper)

  19. Self-enhancement: Conceptualization and Assessment

    Directory of Open Access Journals (Sweden)

    Joachim I. Krueger

    2017-11-01

    Full Text Available Self-enhancement bias is conventionally construed as an unwarranted social comparison in social psychology and a misperception of social reality in personality psychology. Researchers in both fields rely heavily on discrepancy scores to represent self-enhancement and fail to distinguish between a general tendency or bias to self-enhance and a self-enhancement error, or 'false' perception of own excellence. We critically review prominent discrepancy measures and then propose a decision-theoretic alternative that [a] mitigates confounds between self-positivity and self-superiority, [b] separates error from bias, and [c] discourages reliance on measures that reify self-enhancement as a stable personality trait. To evaluate our hypotheses, we re-analyze data collected in our laboratory and perform a series of simulation studies. We share these materials with interested researchers.

  20. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs.

    Science.gov (United States)

    Hah, Nasun; Benner, Chris; Chong, Ling-Wa; Yu, Ruth T; Downes, Michael; Evans, Ronald M

    2015-01-20

    Enhancers are critical genomic elements that define cellular and functional identity through the spatial and temporal regulation of gene expression. Recent studies suggest that key genes regulating cell type-specific functions reside in enhancer-dense genomic regions (i.e., super enhancers, stretch enhancers). Here we report that enhancer RNAs (eRNAs) identified by global nuclear run-on sequencing are extensively transcribed within super enhancers and are dynamically regulated in response to cellular signaling. Using Toll-like receptor 4 (TLR4) signaling in macrophages as a model system, we find that transcription of super enhancer-associated eRNAs is dynamically induced at most of the key genes driving innate immunity and inflammation. Unexpectedly, genes repressed by TLR4 signaling are also associated with super enhancer domains and accompanied by massive repression of eRNA transcription. Furthermore, we find each super enhancer acts as a single regulatory unit within which eRNA and genic transcripts are coordinately regulated. The key regulatory activity of these domains is further supported by the finding that super enhancer-associated transcription factor binding is twice as likely to be conserved between human and mouse than typical enhancer sites. Our study suggests that transcriptional activities at super enhancers are critical components to understand the dynamic gene regulatory network.

  1. Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors

    KAUST Repository

    Pang, J.

    2016-12-28

    Metal enhanced fluorescence (MEF) is a physical effect through which the near-field interaction of fluorophores with metallic nanoparticles can lead to large fluorescence enhancement. MEF can be exploited in many fluorescence-based biomedical applications, with potentially significant improvement in detection sensitivity and contrast enhancement. Offering lower autofluorescence and minimal photoinduced damage, the development of effective and multifunctional MEF platforms in the near-infrared (NIR) region, is particularly desirable. In this work, the enhancement of NIR fluorescence caused by interaction with regular arrays of cylindrical gold (Au) nanoparticles (nanodiscs), fabricated through nanosphere lithography, is reported. Significant MEF of up to 235 times is obtained, with tuneable enhancement factors. The effect of array structure on fluorescence enhancement is investigated by semi-quantitatively de-convoluting excitation enhancement from emission enhancement, and modelling the local electric field enhancement. By considering arrays of Au nanodiscs with the same extinction maximum, it is shown that the excitation enhancement, due to increased electric field, is not significantly different for the particle sizes and separation distances considered. Rather, it is seen that the emission from the fluorophore is strongly enhanced, and is dependent on the topography, in particular particle size. The results show that the structural characteristics of Au nanodisc arrays can be manipulated to tune their enhancement factor, and hence their sensitivity.

  2. A study on enhancing EUV resist sensitivity

    Science.gov (United States)

    Sekiguchi, Atsushi; Harada, Tetsuo; Watanabe, Takeo

    2017-03-01

    Studies have been carried out on developing a method for improving EUV resist sensitivity by enhancing EUV light absorption through the addition of metals having high EUV light absorption to the resist polymer in order to increase secondary electron emission, thereby enhancing PAG reactivity and improving acid generation efficiency[1-3]. To confirm whether the addition of metals having high EUV light absorption actually does enhance sensitivity, study efforts included transmittance measurements and sensitivity evaluations of resist samples doped with ZrO2 or TeO2 nanoparticles, which have low and high EUV light absorption, respectively, in molar quantities of 0-2 relative to PAG. The samples were subjected to EUV exposure at the NewSUBARU synchrotron radiation facility. While the ZrO2-doped resist showed no evident enhancement of sensitivity or transmittance, the TeO2-doped resist showed enhancement in both properties. Based on these results, we confirmed that the addition of metals having high EUV light absorption to the EUV resist enhances its EUV light absorption and increases secondary electron emission, thereby enhancing PAG reactivity and improving acid generation efficiency.

  3. Spectroscopic enhancement in nanoparticles embedded glasses

    Energy Technology Data Exchange (ETDEWEB)

    Sahar, M. R., E-mail: mrahim057@gmail.com; Ghoshal, S. K., E-mail: mrahim057@gmail.com [Advanced Optical Material Research Group, Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor Bahru, Johor (Malaysia)

    2014-09-25

    This presentation provides an overview of the recent progress in the enhancement of the spectroscopic characteristics of the glass embedded with nanoparticles (NPs). Some of our research activities with few significantly new results are highlighted and facilely analyzed. The science and technology dealing with the manipulation of the physical properties of rare earth doped inorganic glasses by embedding metallic NPs or nanoclusters produce the so-called 'nanoglass'. Meanwhile, the spectroscopic enhancement relates the intensity of the luminescence measured at certain transition. The enhancement which expectedly due to the 'plasmonics wave' (referring to the coherent coupling of photons to free electron oscillations called plasmon) occurs at the interface between a conductor and a dielectric. Plasmonics being an emerging concept in advanced optical material of nanophotonics has given this material the ability to exploit the optical response at nanoscale and opened up a new avenue in metal-based glass optics. There is a vast array of plasmonic NPs concepts yet to be explored, with applications spanning solar cells, (bio) sensing, communications, lasers, solid-state lighting, waveguides, imaging, optical data transfer, display and even bio-medicine. Localized surface plasmon resonance (LSPR) can enhance the optical response of nanoglass by orders of magnitude as observed. The luminescence enhancement and surface enhanced Raman scattering (SERS) are new paradigm of research. The enhancement of luminescence due to the influence of metallic NPs is the recurring theme of this paper.

  4. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    International Nuclear Information System (INIS)

    Kawai, Yuichi; Suzuki, Kojiro; Itoh, Shigeki; Takada, Akira; Mori, Yoshine; Naganawa, Shinji

    2012-01-01

    Purpose: To assess the usefulness of the computed tomography (CT) finding of main pancreatic duct (MPD) wall enhancement, termed the “enhanced duct sign”, for diagnosis of autoimmune pancreatitis (AIP) in comparison with diagnosis of pancreatic carcinoma and chronic pancreatitis. Materials and methods: Two radiologists independently evaluated the presence or absence of the enhanced duct sign on multiphase contrast-enhanced CT in patients with AIP (n = 55), pancreatic carcinoma (n = 50), and chronic pancreatitis (n = 50). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of AIP were calculated. In patients demonstrating the enhanced duct sign, additional findings were evaluated by consensus. Results: The enhanced duct sign was more frequently observed in patients with AIP (37/55, 67%) than in patients with pancreatic carcinoma (5/50, 10%) or chronic pancreatitis (0/50, 0%) (P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the finding were 0.67, 0.95, 0.85, 0.88, and 0.84, respectively. In AIP, the lumen within the enhanced duct was completely or partially invisible in 29 of 37 (78%) patients, and the enhanced duct was observed within the affected pancreatic parenchyma in 35 of 37 (95%) patients. In pancreatic carcinoma, the lumen within the enhanced duct was visible in all patients (5/5, 100%), and the enhanced duct was observed downstream of the tumor (5/5, 100%). Conclusion: The enhanced duct sign is highly specific of AIP.

  5. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, Yuichi, E-mail: kawai.yuichi@a.mbox.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Suzuki, Kojiro, E-mail: kojiro@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Itoh, Shigeki, E-mail: shigeito@nagoya-1st.jrc.or.jp [Department of Diagnostic Radiology, Japan Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya 453-8511 (Japan); Takada, Akira, E-mail: takadaa@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Mori, Yoshine, E-mail: yoshine@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Naganawa, Shinji, E-mail: naganawa@med.nagoya-u.ac.jp [Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan)

    2012-11-15

    Purpose: To assess the usefulness of the computed tomography (CT) finding of main pancreatic duct (MPD) wall enhancement, termed the 'enhanced duct sign', for diagnosis of autoimmune pancreatitis (AIP) in comparison with diagnosis of pancreatic carcinoma and chronic pancreatitis. Materials and methods: Two radiologists independently evaluated the presence or absence of the enhanced duct sign on multiphase contrast-enhanced CT in patients with AIP (n = 55), pancreatic carcinoma (n = 50), and chronic pancreatitis (n = 50). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of AIP were calculated. In patients demonstrating the enhanced duct sign, additional findings were evaluated by consensus. Results: The enhanced duct sign was more frequently observed in patients with AIP (37/55, 67%) than in patients with pancreatic carcinoma (5/50, 10%) or chronic pancreatitis (0/50, 0%) (P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the finding were 0.67, 0.95, 0.85, 0.88, and 0.84, respectively. In AIP, the lumen within the enhanced duct was completely or partially invisible in 29 of 37 (78%) patients, and the enhanced duct was observed within the affected pancreatic parenchyma in 35 of 37 (95%) patients. In pancreatic carcinoma, the lumen within the enhanced duct was visible in all patients (5/5, 100%), and the enhanced duct was observed downstream of the tumor (5/5, 100%). Conclusion: The enhanced duct sign is highly specific of AIP.

  6. Enhanced Graphene Photodetector with Fractal Metasurface

    DEFF Research Database (Denmark)

    Fang, Jieran; Wang, Di; DeVault, Clayton T

    2017-01-01

    optical absorption, which hinders its incorporation with modern photodetecting systems. In this work, we propose a gold snowflake-like fractal metasurface design to realize broadband and polarization-insensitive plasmonic enhancement in graphene photodetector. We experimentally obtain an enhanced...... photovoltage from the fractal metasurface that is an order of magnitude greater than that generated at a plain gold-graphene edge and such an enhancement in the photovoltage sustains over the entire visible spectrum. We also observed a relatively constant photoresponse with respect to polarization angles...... of incident light, as a result of the combination of two orthogonally oriented concentric hexagonal fractal geometries in one metasurface....

  7. Enhancing Rotational Diffusion Using Oscillatory Shear

    KAUST Repository

    Leahy, Brian D.

    2013-05-29

    Taylor dispersion - shear-induced enhancement of translational diffusion - is an important phenomenon with applications ranging from pharmacology to geology. Through experiments and simulations, we show that rotational diffusion is also enhanced for anisotropic particles in oscillatory shear. This enhancement arises from variations in the particle\\'s rotation (Jeffery orbit) and depends on the strain amplitude, rate, and particle aspect ratio in a manner that is distinct from the translational diffusion. This separate tunability of translational and rotational diffusion opens the door to new techniques for controlling positions and orientations of suspended anisotropic colloids. © 2013 American Physical Society.

  8. Mechanisms of enhanced lung injury during sepsis

    DEFF Research Database (Denmark)

    Czermak, B J; Breckwoldt, M; Ravage, Z B

    1999-01-01

    to injury after a direct pulmonary insult (deposition of IgG immune complexes or airway instillation of lipopolysaccharide). By itself, cecal ligation/puncture did not produce evidence of lung injury. However, after a direct pulmonary insult, lung injury in septic animals was significantly enhanced...... or treatment with anti-C5a abolished all evidence of enhanced lung injury in septic animals. When stimulated in vitro, bronchoalveolar lavage macrophages from septic animals had greatly enhanced CXC chemokine responses as compared with macrophages from sham-operated animals or from septic animals that had been...

  9. Acoustic Purcell Effect for Enhanced Emission

    KAUST Repository

    Landi, Maryam

    2018-03-13

    We observe that our experimentally measured emission power enhancement of a speaker inside a previously proposed metacavity agrees with our numerically calculated enhancement of the density of states (DOS) of the source-cavity system. We interpret the agreement by formulating a relation between the emitted sound power and the acoustic DOS. The formulation is an analog to Fermi’s golden rule in quantum emission. The formulation complements the radiation impedance theory in traditional acoustics for describing sound emission. Our study bridges the gap between acoustic DOS and the acoustic Purcell effect for sound emission enhancement.

  10. Enhancement of Retronasal Odors by Taste

    OpenAIRE

    Green, Barry G.; Nachtigal, Danielle; Hammond, Samuel; Lim, Juyun

    2011-01-01

    Psychophysical studies of interactions between retronasal olfaction and taste have focused most often on the enhancement of tastes by odors, which has been attributed primarily to a response bias (i.e., halo dumping). Based upon preliminary evidence that retronasal odors could also be enhanced by taste, the present study measured both forms of enhancement using appropriate response categories. In the first experiment, subjects rated taste (“sweet,” “sour,” “salty,” and “bitter”) and odor (“ot...

  11. Enhanced parametric processes in binary metamaterials

    OpenAIRE

    Gorkunov, Maxim V.; Shadrivov, Ilya V.; Kivshar, Yuri S.

    2005-01-01

    We suggest double-resonant (binary) metamaterials composed of two types of magnetic resonant elements, and demonstrate that in the nonlinear regime such metamaterials provide unique possibilities for phase-matched parametric interaction and enhanced second-harmonic generation.

  12. Enhancing Metacognitive Practices in Science Education Students ...

    African Journals Online (AJOL)

    Enhancing Metacognitive Practices in Science Education Students Using the Intelligencies for Nation Building. ... AFRREV STECH: An International Journal of Science and Technology ... Three experts from Measurement and Evaluation (2) and one from Science Education scrutinized the instrument to ensure validity.

  13. Performance-Enhancing Drugs: Know the Risks

    Science.gov (United States)

    ... high doses of caffeine and other stimulants. The street drugs cocaine and methamphetamine also are stimulants. Risks ... healthy-lifestyle/fitness/in-depth/performance-enhancing-drugs/art-20046134 . Mayo Clinic Footer Legal Conditions and Terms ...

  14. Is enhanced MRI helpful in brainstem infarction?

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Y. M.; Shin, G. H.; Choi, W. S. [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    1994-12-15

    To determine the role of MR contrast enhancement in evaluating time course of brainstem infarction. MR imaging with IV administration of gadopentetate dimeglumine was retrospectively reviewed in 43 patients with clinically and radiologically documented brainstem infarctions. The pattern of infarction was classified into spotty and patchy. Presence of parenchymal enhancement in infarction was evaluated. By location, there were 34 pontine, 3 midbrain, 6 medullary infarctions. The age of the infarctions ranged from 1 day to 9 months, with 5 patients scanned within 3 days and 10 scanned within 2 weeks of clinical ictus. Abnormalities on T2-weighted images were encountered in every case, with spotty pattern in 14 cases and patchy pattern in 29 cases. Parenchymal contrast enhancement was seen in 9 cases(20%), primarily occurring between days 8 and 20. MR contrast enhancement in brainstem infarction was infrequent that it may not be useful in the estimation of the age of infarction.

  15. Enhanced Brine Dewatering System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of the Enhanced Brine Dewatering System (EBDS) is to provide an easily scalable means of completely recovering usable water from byproducts created by...

  16. Gd enhanced MRI in sensorineural hearing loss

    Energy Technology Data Exchange (ETDEWEB)

    Takenaka, Mika; Tono, Tetsuya; Toyama, Katsuhiro; Kano, Kiyo; Morimitsu, Tamotsu [Miyazaki Medical Coll., Kiyotake (Japan)

    1996-09-01

    The enhanced MRI hearing findings of the inner ear in 124 patients with sensorineural hearing loss were evaluated. MR images were obtained before and after the intravenous administration of gadolinium (0.1 mmol/kg). In three out of seventy-nine patients with unilateral healing loss, cochlear and/or the vestibular enhancement was noted on the symptomatic side. The positive cases included those with Ramsay-Hunt syndrome, mumps and so-called sudden deafness. Forty-five patients with bilateral hearing loss showed no enhancement within the inner ear. Although positive gadolinium enhancement of the inner ear may detect inflammatory lesions due to a viral infection, its incidence in sensorineural hearing loss, including cases of sudden deafness. seems to be extremely rare. (author)

  17. Recommender Systems in Technology Enhanced Learning

    NARCIS (Netherlands)

    Manouselis, Nikos; Drachsler, Hendrik; Vuorikari, Riina; Hummel, Hans; Koper, Rob

    2010-01-01

    Manouselis, N., Drachsler, H., Vuorikari, R., Hummel, H. G. K., & Koper, R. (2011). Recommender Systems in Technology Enhanced Learning. In P. B. Kantor, F. Ricci, L. Rokach, & B. Shapira (Eds.), Recommender Systems Handbook (pp. 387-415). Berlin: Springer.

  18. Resonant metallic nanostructures for enhanced terahertz spectroscopy

    KAUST Repository

    Toma, A.

    2015-11-12

    We present our recent studies on terahertz resonant dipole nanoantennas. Exploiting the localization and enhancement capabilities of these devices, we introduce an effective method to perform terahertz spectroscopy on an extremely small number of nano-objects.

  19. Enhancements to highway construction scheduling expert system.

    Science.gov (United States)

    2015-05-01

    This research was performed to enhance the software tool (Illinois Construction Scheduling Expert : System, ICSES) developed in Phase I of this project (ICT project R27-86) by mining data collected on : IDOT construction projects and differentiating ...

  20. Signal enhancement with variable span linear filters

    CERN Document Server

    Benesty, Jacob; Jensen, Jesper R

    2016-01-01

    This book introduces readers to the novel concept of variable span speech enhancement filters, and demonstrates how it can be used for effective noise reduction in various ways. Further, the book provides the accompanying Matlab code, allowing readers to easily implement the main ideas discussed. Variable span filters combine the ideas of optimal linear filters with those of subspace methods, as they involve the joint diagonalization of the correlation matrices of the desired signal and the noise. The book shows how some well-known filter designs, e.g. the minimum distortion, maximum signal-to-noise ratio, Wiener, and tradeoff filters (including their new generalizations) can be obtained using the variable span filter framework. It then illustrates how the variable span filters can be applied in various contexts, namely in single-channel STFT-based enhancement, in multichannel enhancement in both the time and STFT domains, and, lastly, in time-domain binaural enhancement. In these contexts, the properties of ...

  1. Systems and methods for enhancing optical information

    Energy Technology Data Exchange (ETDEWEB)

    DeVore, Peter Thomas Setsuda; Chou, Jason T.

    2018-01-02

    An Optical Information Transfer Enhancer System includes a first system for producing an information bearing first optical wave that is impressed with a first information having a first information strength wherein the first optical wave has a first shape. A second system produces a second optical wave. An information strength enhancer module receives the first and said second optical waves and impresses the first optical wave upon the second optical wave via cross-phase modulation (XPM) to produce an information-strength-enhanced second optical wave having a second information strength that is greater than the first information strength of the first optical wave. Following a center-wavelength changer by an Optical Information Transfer Enhancer System improves its performance.

  2. Plasmon resonance enhanced multicolour photodetection by graphene.

    Science.gov (United States)

    Liu, Yuan; Cheng, Rui; Liao, Lei; Zhou, Hailong; Bai, Jingwei; Liu, Gang; Liu, Lixin; Huang, Yu; Duan, Xiangfeng

    2011-12-06

    Graphene has the potential for high-speed, wide-band photodetection, but only with very low external quantum efficiency and no spectral selectivity. Here we report a dramatic enhancement of the overall quantum efficiency and spectral selectivity that enables multicolour photodetection, by coupling graphene with plasmonic nanostructures. We show that metallic plasmonic nanostructures can be integrated with graphene photodetectors to greatly enhance the photocurrent and external quantum efficiency by up to 1,500%. Plasmonic nanostructures of variable resonance frequencies selectively amplify the photoresponse of graphene to light of different wavelengths, enabling highly specific detection of multicolours. Being atomically thin, graphene photodetectors effectively exploit the local plasmonic enhancement effect to achieve a significant enhancement factor not normally possible with traditional planar semiconductor materials.

  3. Viability of Biopolymers for Enhanced Oil Recovery

    NARCIS (Netherlands)

    Sveistrup, Marte; van Mastrigt, Frank; Norrman, Jens; Picchioni, Francesco; Paso, Kristofer

    2016-01-01

    Xanthan gum and scleroglucan are assessed as environmentally friendly enhanced oil recovery (EOR) agents. Viscometric and interfacial tension measurements show that the polysaccharides exhibit favorable viscosifying performance, robust shear tolerance, electrolyte tolerance, and moderate

  4. Enhancement of proton conductivity of sulfonated polystyrene ...

    Indian Academy of Sciences (India)

    Enhancement of proton conductivity of sulfonated polystyrene membrane prepared by plasma polymerization process. BHABESH KUMAR NATH, AZIZ KHAN, JOYANTI CHUTIA. ∗. , ARUP RATAN PAL,. HEREMBA BAILUNG, NEELOTPAL SEN SARMA, DEVASISH CHOWDHURY and NIRAB CHANDRA ADHIKARY.

  5. Technology-enhanced learning in the workplace

    NARCIS (Netherlands)

    Van der Klink, Marcel; Drachsler, Hendrik; Sloep, Peter

    2011-01-01

    Van der Klink, M., Drachsler, H., & Sloep, P. B. (2013). Technology-enhanced learning in the workplace. In D. Derks, & A. B. Bakker (Eds.), The psychology of ditigal media @ work (pp. 145-165). London, UK: Psychology Press.

  6. Strategy to Enhance International Supply Chain Security

    National Research Council Canada - National Science Library

    2007-01-01

    .... at 1901, 1903, October 13, 2006) which require the development of a strategic plan to enhance the security of the international supply chain, including protocols for the expeditious resumption of the flow of trade following...

  7. Five Performance Enhancements for Hybrid Hash Join

    National Research Council Canada - National Science Library

    Graefe, Goetz

    1992-01-01

    .... We discuss five performance enhancements for hybrid hash join algorithms, namely data compression, large cluster sizes and multi-level recursion, role reversal of build and probe inputs, histogram...

  8. Visualization of Enhancer-Derived Noncoding RNA.

    Science.gov (United States)

    Shibayama, Youtaro; Fanucchi, Stephanie; Mhlanga, Musa M

    2017-01-01

    Enhancers are principal regulators that allow spatiotemporal tissue-specific control of gene expression. While mounting evidence suggests that enhancer-derived long noncoding RNAs (long ncRNAs), including enhancer RNAs (eRNAs), are an important component of enhancer function, their expression has not been broadly analyzed at a single cell level via imaging techniques. This protocol describes a method to image eRNA in single cells by in situ hybridization followed by tyramide signal amplification (TSA). The procedure can be multiplexed to simultaneously visualize both eRNA and protein-coding transcript at the site of transcriptional elongation, thereby permitting analysis of dynamics between the two transcript species in single cells. Our approach is not limited to eRNAs, but can be implemented on other transcripts.

  9. Enhancing Mental Readiness in Military Personnel

    National Research Council Canada - National Science Library

    Thompson, Megan M; McCreary, Donald R

    2006-01-01

    In this paper we explore how the psychological literature on stress and coping might inform military training programs to enhance "mental readiness" as a method to develop the baseline psychological...

  10. ENHANCING WRITING ABILITY THROUGH IDEA LISTING TECHNIQUE

    Directory of Open Access Journals (Sweden)

    M. Zaini Miftah

    2015-05-01

    Full Text Available The study is aimed at developing the Idea Listing Technique (ILT to enhance the students‟ writing ability. The Classroom Action Research was applied in this study. The subjects of the study were 31 students, the students taking the course of Writing II, of the third semester of English Department of one State Islamic College at Palangka Raya, Indonesia, in the 2012/2013 academic year. The findings show that the implementation of ILT can enhance the students‟ ability in writing expository paragraph. It is indicated by the enhancements of the percentage of the students achieving the score greater than or equal to C (60-69, and of the percentage of their involvement in the writing activities during the implementation of ILT in Cycle I and II. Thus, the enhancement of the students‟ ability in writing expository paragraph can be reached but it should follow the appropriate procedures of the implementation of ILT having been developed.

  11. Performance-Enhancing Drugs and Teen Athletes

    Science.gov (United States)

    ... to using performance-enhancing drugs. So it's no surprise that as many as 1 in 20 teenagers ... Clinic does not endorse any of the third party products and services advertised. Advertising and sponsorship policy ...

  12. Enhanced Brine Dewatering System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of the Enhanced Brine Dewatering System (EBDS) is to provide a scalable means of completely recovering usable water from byproducts created by reverse...

  13. An Evaluation of Enhanced Geothermal Systems Technology

    Energy Technology Data Exchange (ETDEWEB)

    Jelacic, Allan [U.S. Dept. of Energy, Washington, DC (United States); Fortuna, Raymond [U.S. Dept. of Energy, Washington, DC (United States); LaSala, Raymond [U.S. Dept. of Energy, Washington, DC (United States); Nathwani, Jay [U.S. Dept. of Energy, Washington, DC (United States); Nix, Gerald [U.S. Dept. of Energy, Washington, DC (United States); Visser, Charles [National Renewable Energy Lab. (NREL), Golden, CO (United States); Green, Bruce [National Renewable Energy Lab. (NREL), Golden, CO (United States); Renner, Joel [Idaho National Lab. (INL), Idaho Falls, ID (United States); Blankenship, Douglas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kennedy, Mack [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bruton, Carol [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2008-04-01

    This 2008 document presents the results of an eight-month study by the Department of Energy (DOE) and its support staff at the national laboratories concerning the technological requirements to commercialize a new geothermal technology, Enhanced Geothermal Systems (EGS).

  14. Open-ring enhancement sign in diagnosing demyelinating pseudotumor

    International Nuclear Information System (INIS)

    Fang Liting; Wang Zhiping; Wang Linyou

    2010-01-01

    Objective: To describe open-ring enhancement sign on MRI of demyelinating pseudotumor. Methods: Contrast-enhanced MRI of histologically confirmed demyelinating pseudotumors (14 patients) and astrocytomas (21) was reviewed. Results: Of the 14 cases of demyelinating pseudotumor, open-ring enhancement pattern was observed in 6; closed ring enhancement in 2; nodular enhancement in 3; patchy enhancement in 1; slight enhancement in 1; and no enhancement in 1. Of the 21 cases of astrocytoma, there was complete ring or lace-like enhancement in 13, no contrast enhancement in 6, patchy enhancement in 2, and none with open-ring enhancement pattern. Conclusion: Open-ring enhancement is a valuable sign in differential diagnosis between demyelinating pseudotumor and astrocytoma. (authors)

  15. Salmon River Habitat Enhancement. 1990 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, Mike

    1991-12-01

    The annual report contains three individual subproject sections detailing tribal fisheries work completed during the summer and fall of 1990. Subproject I contains summaries of evaluation/monitoring efforts associated with the Bear Valley Creek, Idaho enhancement project. Subproject II contains an evaluation of the Yankee Fork of the Salmon River habitat enhancement project. Subproject III concerns the East Fork of the Salmon River, Idaho.

  16. Recent Progress on Plasmon-Enhanced Fluorescence

    Directory of Open Access Journals (Sweden)

    Dong Jun

    2015-12-01

    Full Text Available The optically generated collective electron density waves on metal–dielectric boundaries known as surface plasmons have been of great scientific interest since their discovery. Being electromagnetic waves on gold or silver nanoparticle’s surface, localised surface plasmons (LSP can strongly enhance the electromagnetic field. These strong electromagnetic fields near the metal surfaces have been used in various applications like surface enhanced spectroscopy (SES, plasmonic lithography, plasmonic trapping of particles, and plasmonic catalysis. Resonant coupling of LSPs to fluorophore can strongly enhance the emission intensity, the angular distribution, and the polarisation of the emitted radiation and even the speed of radiative decay, which is so-called plasmon enhanced fluorescence (PEF. As a result, more and more reports on surface-enhanced fluorescence have appeared, such as SPASER-s, plasmon assisted lasing, single molecule fluorescence measurements, surface plasmoncoupled emission (SPCE in biological sensing, optical orbit designs etc. In this review, we focus on recent advanced reports on plasmon-enhanced fluorescence (PEF. First, the mechanism of PEF and early results of enhanced fluorescence observed by metal nanostructure will be introduced. Then, the enhanced substrates, including periodical and nonperiodical nanostructure, will be discussed and the most important factor of the spacer between molecule and surface and wavelength dependence on PEF is demonstrated. Finally, the recent progress of tipenhanced fluorescence and PEF from the rare-earth doped up-conversion (UC and down-conversion (DC nanoparticles (NPs are also commented upon. This review provides an introduction to fundamentals of PEF, illustrates the current progress in the design of metallic nanostructures for efficient fluorescence signal amplification that utilises propagating and localised surface plasmons.

  17. Enhanced Graphene Photodetector with Fractal Metasurface

    DEFF Research Database (Denmark)

    Fan, Jieran; Wang, Di; DeVault, Clayton

    2016-01-01

    We designed and fabricated a broadband, polarization-independent photodetector by integrating graphene with a fractal Cayley tree metasurface. Our measurements show an almost uniform, tenfold enhancement in photocurrent generation due to the fractal metasurface structure.......We designed and fabricated a broadband, polarization-independent photodetector by integrating graphene with a fractal Cayley tree metasurface. Our measurements show an almost uniform, tenfold enhancement in photocurrent generation due to the fractal metasurface structure....

  18. Methylphenidate enhances extinction of contextual fear

    OpenAIRE

    Abraham, Antony D.; Cunningham, Christopher L.; Lattal, K. Matthew

    2012-01-01

    Methylphenidate (MPH, Ritalin) is a norepinephrine and dopamine transporter blocker that is widely used in humans for treatment of attention deficit disorder and narcolepsy. Although there is some evidence that targeted microinjections of MPH may enhance fear acquisition, little is known about the effect of MPH on fear extinction. Here, we show that MPH, administered before or immediately following extinction of contextual fear, will enhance extinction retention in C57BL/6 mice. Animals that ...

  19. Mobile, Virtual Enhancements for Rehabilitation (MOVER)

    Science.gov (United States)

    2015-08-28

    The patient uses COTS input devices, such as the Microsoft Kinect and the Wii Balance Board , to perform therapeutic exercises that are mapped to...0359 Total Award Value: $767,388 Charles River Analytics Contract No. C12198 Mobile, Virtual Enhancements for Rehabilitation (MOVER) Quarterly...2015 2. REPORT TYPE 3. DATES COVERED 01-06-2014 to 28-08-2015 4. TITLE AND SUBTITLE Mobile, Virtual Enhancements for Rehabilitation (MOVER) 5a

  20. Enhancing the magnetic properties of magnetic nanoparticles

    DEFF Research Database (Denmark)

    Ahlburg, Jakob; Saura-Múzquiz, Matilde; Stingaciu, Marian

    with a similar magnetic performance. There are several different ways of enhancing magnetic properties of 3d magnetic compounds. This includes, size control, core-shell particles or mixing hard and soft magnetic materials together to achieve an exchange coupling between the compounds and enhancing the magnetic...... energy product. In order to control the particle size, a hydrothermal synthesis is preferred. This followed by reduction or the oxides into either core shell particles, or a mixture of magnetic oxides and a metallic phase....

  1. Enhancing the magnetic properties of magnetic nanoparticles

    DEFF Research Database (Denmark)

    Ahlburg, Jakob; Saura-Múzquiz, Matilde; Stingaciu, Marian

    ways of enhancing magnetic properties of 3d magnetic compounds. This includes, size control, core-shell particles or mixing hard and soft magnetic materials together to achieve an exchange coupling between the compounds and enhancing the magnetic energy product. In order to control the particle size......, a hydrothermal synthesis is preferred. This followed by reduction or the oxides into either core shell particles, or a mixture of magnetic oxides and a metallic phase....

  2. Enhancing ELT through self-assessment

    OpenAIRE

    Abu_Rahmah, Mohamed Ismail; Al-Humaidi, Salma Hamed

    2013-01-01

    This qualitative study was an attempt to enhance English language teaching and learning through the employment of some self-assessment techniques.  Towards this end, the writers reviewed the various definitions of the term self-assessment, its pedagogical benefits and the studies conducted to investigate its effect on other ELT variables such as language skills, linguistic competence, self-efficacy, and learner autonomy. Accordingly, it was hypothesized that self-assessment could enhance ELT....

  3. Distributed fingerprint enhancement on a multicore cluster

    CSIR Research Space (South Africa)

    Khanyile, NP

    2012-07-01

    Full Text Available and memory distribution. Section 4 gives the algorithms description, while Section 5 introduces ways to deal with boundary pixels. Section 6 presents the performance analysis and Section 7 is devoted to conclusions and future works. 2. Background 2..., image enhancement is very crucial yet very computationally expensive. Sensing devices rarely produce perfect ready for use input images. Images are often corrupted by noise and by variations in fingerprint impression conditions. Image enhancement...

  4. Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation.

    Science.gov (United States)

    Hsieh, Chen-Lin; Fei, Teng; Chen, Yiwen; Li, Tiantian; Gao, Yanfei; Wang, Xiaodong; Sun, Tong; Sweeney, Christopher J; Lee, Gwo-Shu Mary; Chen, Shaoyong; Balk, Steven P; Liu, Xiaole Shirley; Brown, Myles; Kantoff, Philip W

    2014-05-20

    The androgen receptor (AR) is a key factor that regulates the behavior and fate of prostate cancer cells. The AR-regulated network is activated when AR binds enhancer elements and modulates specific enhancer-promoter looping. Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene and its upstream enhancers produce bidirectional enhancer RNAs (eRNAs), termed KLK3e. Here, we demonstrate that KLK3e facilitates the spatial interaction of the KLK3 enhancer and the KLK2 promoter and enhances long-distance KLK2 transcriptional activation. KLK3e carries the core enhancer element derived from the androgen response element III (ARE III), which is required for the interaction of AR and Mediator 1 (Med1). Furthermore, we show that KLK3e processes RNA-dependent enhancer activity depending on the integrity of core enhancer elements. The transcription of KLK3e was detectable and its expression is significantly correlated with KLK3 (R(2) = 0.6213, P enhances AR-dependent gene expression.

  5. Dissemination of radiological information using enhanced podcasts.

    Science.gov (United States)

    Thapa, Mahesh M; Richardson, Michael L

    2010-03-01

    Podcasts and vodcasts (video podcasts) have become popular means of sharing educational information via the Internet. In this article, we introduce another method, an enhanced podcast, which allows images to be displayed with the audio. Bookmarks and URLs may also be imbedded within the presentation. This article describes a step-by-step tutorial for recording and distributing an enhanced podcast using the Macintosh operating system. Enhanced podcasts can also be created on the Windows platform using other software. An example of an enhanced podcast and a demonstration video of all the steps described in this article are available online at web.mac.com/mthapa. An enhanced podcast is an effective method of delivering radiological information via the Internet. Viewing images while simultaneously listening to audio content allows the user to have a richer experience than with a simple podcast. Incorporation of bookmarks and URLs within the presentation will make learning more efficient and interactive. The use of still images rather than video clips equates to a much smaller file size for an enhanced podcast compared to a vodcast, allowing quicker upload and download times.

  6. Localized basal meningeal enhancement in tuberculous meningitis

    Energy Technology Data Exchange (ETDEWEB)

    Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du [University of Stellenbosch, Department of Radiology, Tygerberg Hospital, P.O. BOX 19063, Tygerberg (South Africa)

    2006-11-15

    Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

  7. Neurostimulation for Memory Enhancement in Epilepsy.

    Science.gov (United States)

    Meisenhelter, Stephen; Jobst, Barbara C

    2018-04-19

    Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of memory enhancement using transcranial electrical stimulation (tES), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), chronic intracranial stimulation, and acute intracranial stimulation. Existing literature suggests that transcranial direct current stimulation (tDCS) produces a small enhancement in memory in neuropsychological patients, but transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) have not been found to have an effect on memory. Most studies of transcranial magnetic stimulation (TMS) have found that TMS has no positive effect on memory. Vagus nerve stimulation can acutely enhance memory, while chronic therapy does not appear to alter memory performance. We found that there is the most evidence for significant memory enhancement using intracranial stimulation techniques, especially chronic stimulation of the fornix and task-responsive stimulation of the lateral temporal lobe. Presently, there are no existing therapeutic options for directly treating epilepy-related memory deficits. While neurostimulation technologies for memory enhancement are largely still in the experimental phase, neurostimulation appears promising as a future technique for treating epilepsy-related memory deficits.

  8. Contrast Enhanced US in the Abdomen

    International Nuclear Information System (INIS)

    Chung, Yong Eun; Kim, Ki Whang

    2012-01-01

    Contrast enhanced ultrasound, which was introduced in 1996, has been widely used in Europe and Eastern Asia. Ultrasound contrast agent can be classified as first generation and second generation, depending on the gas within the microbubble. With the first generation contrast agent, the high MI technique was used, and only intermittent scanning was possible due to destruction of the microbubble during scanning. Use of the second generation contrast agent with the low MI technique makes continuous scanning possible. Contrast enhanced US can be used in detection and differentiation of focal liver lesions. It is also helpful for monitoring of radiofrequency ablation and for targeting of US guided biopsy. Currently, because morphologic criteria alone may not reflect the response of the tumor to treatment, new criteria are needed for treatment evaluation after administration of anti-angiogenic agents. Contrast enhanced US could provide quantitative markers for evaluation of the response to treatment via use of dynamic contrast enhanced US. Due to cost-effectiveness, contrast enhanced US is not yet widely used in Korea; however, considering recent issues regarding contrast agent related adverse reaction, such as contrast induced nephropathy and nephrogenic systemic fibrosis, and radiation exposure, contrast enhanced US might be more widely used in Korea, as an alternative imaging modality in the future.

  9. Enhancement of Cellulose Degradation by Cattle Saliva

    Science.gov (United States)

    Seki, Yasutaka; Kikuchi, Yukiko; Kimura, Yoshihiro; Yoshimoto, Ryo; Takahashi, Masatoshi; Aburai, Kenichi; Kanai, Yoshihiro; Ruike, Tatsushi; Iwabata, Kazuki; Sugawara, Fumio; Sakai, Hideki; Abe, Masahiko; Sakaguchi, Kengo

    2015-01-01

    Saccharification of cellulose is a promising technique for producing alternative source of energy. However, the efficiency of conversion of cellulose into soluble sugar using any currently available methodology is too low for industrial application. Many additives, such as surfactants, have been shown to enhance the efficiency of cellulose-to-sugar conversion. In this study, we have examined first whether cattle saliva, as an additive, would enhance the cellulase-catalyzed hydrolysis of cellulose, and subsequently elucidated the mechanism by which cattle saliva enhanced this conversion. Although cattle saliva, by itself, did not degrade cellulose, it enhanced the cellulase-catalyzed degradation of cellulose. Thus, the amount of reducing sugar produced increased approximately 2.9-fold by the addition of cattle saliva. We also found that non-enzymatic proteins, which were present in cattle saliva, were responsible for causing the enhancement effect. Third, the mechanism of cattle saliva mediated enhancement of cellulase activity was probably similar to that of the canonical surfactants. Cattle saliva is available in large amounts easily and cheaply, and it can be used without further purification. Thus, cattle saliva could be a promising additive for efficient saccharification of cellulose on an industrial scale. PMID:26402242

  10. Chromatin remodeling effects on enhancer activity.

    Science.gov (United States)

    García-González, Estela; Escamilla-Del-Arenal, Martín; Arzate-Mejía, Rodrigo; Recillas-Targa, Félix

    2016-08-01

    During organism development, a diversity of cell types emerges with disparate, yet stable profiles of gene expression with distinctive cellular functions. In addition to gene promoters, the genome contains enhancer regulatory sequences, which are implicated in cellular specialization by facilitating cell-type and tissue-specific gene expression. Enhancers are DNA binding elements characterized by highly sophisticated and various mechanisms of action allowing for the specific interaction of general and tissue-specific transcription factors (TFs). However, eukaryotic organisms package their genetic material into chromatin, generating a physical barrier for TFs to interact with their cognate sequences. The ability of TFs to bind DNA regulatory elements is also modulated by changes in the chromatin structure, including histone modifications, histone variants, ATP-dependent chromatin remodeling, and the methylation status of DNA. Furthermore, it has recently been revealed that enhancer sequences are also transcribed into a set of enhancer RNAs with regulatory potential. These interdependent processes act in the context of a complex network of chromatin interactions, which together contributes to a renewed vision of how gene activation is coordinated in a cell-type-dependent manner. In this review, we describe the interplay between genetic and epigenetic aspects associated with enhancers and discuss their possible roles on enhancer function.

  11. Integrator mediates the biogenesis of enhancer RNAs.

    Science.gov (United States)

    Lai, Fan; Gardini, Alessandro; Zhang, Anda; Shiekhattar, Ramin

    2015-09-17

    Integrator is a multi-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII). Integrator is endowed with a core catalytic RNA endonuclease activity, which is required for the 3'-end processing of non-polyadenylated, RNAPII-dependent, uridylate-rich, small nuclear RNA genes. Here we examine the requirement of Integrator in the biogenesis of transcripts derived from distal regulatory elements (enhancers) involved in tissue- and temporal-specific regulation of gene expression in metazoans. Integrator is recruited to enhancers and super-enhancers in a stimulus-dependent manner. Functional depletion of Integrator subunits diminishes the signal-dependent induction of enhancer RNAs (eRNAs) and abrogates stimulus-induced enhancer-promoter chromatin looping. Global nuclear run-on and RNAPII profiling reveals a role for Integrator in 3'-end cleavage of eRNA primary transcripts leading to transcriptional termination. In the absence of Integrator, eRNAs remain bound to RNAPII and their primary transcripts accumulate. Notably, the induction of eRNAs and gene expression responsiveness requires the catalytic activity of Integrator complex. We propose a role for Integrator in biogenesis of eRNAs and enhancer function in metazoans.

  12. An enhanced fractal image denoising algorithm

    International Nuclear Information System (INIS)

    Lu Jian; Ye Zhongxing; Zou Yuru; Ye Ruisong

    2008-01-01

    In recent years, there has been a significant development in image denoising using fractal-based method. This paper presents an enhanced fractal predictive denoising algorithm for denoising the images corrupted by an additive white Gaussian noise (AWGN) by using quadratic gray-level function. Meanwhile, a quantization method for the fractal gray-level coefficients of the quadratic function is proposed to strictly guarantee the contractivity requirement of the enhanced fractal coding, and in terms of the quality of the fractal representation measured by PSNR, the enhanced fractal image coding using quadratic gray-level function generally performs better than the standard fractal coding using linear gray-level function. Based on this enhanced fractal coding, the enhanced fractal image denoising is implemented by estimating the fractal gray-level coefficients of the quadratic function of the noiseless image from its noisy observation. Experimental results show that, compared with other standard fractal-based image denoising schemes using linear gray-level function, the enhanced fractal denoising algorithm can improve the quality of the restored image efficiently

  13. Localized basal meningeal enhancement in tuberculous meningitis

    International Nuclear Information System (INIS)

    Theron, Salomine; Andronikou, Savvas; Grobbelaar, Marie; Steyn, Freda; Mapukata, Ayanda; Plessis, Jaco du

    2006-01-01

    Focal basal meningeal enhancement may produce a confusing CT picture in children with suspected tuberculous meningitis (TBM). To demonstrate the incidence, distribution and appearance of localized basal meningeal enhancement in children with TBM. CT scans of patients with definite (culture proven) and probable (CSF suggestive) TBM were retrospectively evaluated by two observers. Localized basal enhancement was documented as involving: unilateral cistern of the lateral fossa (CLF), unilateral sylvian fissure, unilateral CLF and sylvian fissure in combination, unilateral CLF and sylvian fissure with ipsi- or contralateral ambient cistern and isolated quadrigeminal plate cistern. The study included 130 patients with TBM (aged 2 months to 13 years 9 months). Focal basal enhancement was seen in 11 patients (8.5%). The sylvian fissure was involved most commonly, followed by the lateral fossa cistern. The ambient cistern was involved in three patients and the quadrigeminal plate cistern in one. Focal areas of enhancement corresponded to the areas of infarction in every patient. Focal basal meningeal enhancement is common (8.5%) in paediatric TBM. This must be kept in mind when evaluating CT scans in children presenting with focal neurological findings, seizures or meningism in communities where TBM is endemic. (orig.)

  14. Enhancer RNAs: a class of long noncoding RNAs synthesized at enhancers.

    Science.gov (United States)

    Kim, Tae-Kyung; Hemberg, Martin; Gray, Jesse M

    2015-01-05

    Recent studies have revealed that active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription. Emerging studies, showing that eRNAs function in controlling mRNA transcription, challenge the idea that enhancers are merely sites of transcription factor assembly. Instead, communication between promoters and enhancers can be bidirectional with promoters required to activate enhancer transcription. Reciprocally, eRNAs may then facilitate enhancer-promoter interaction or activate promoter-driven transcription. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

  15. Evaluation of carotid vessel wall enhancement with image subtraction after gadobenate dimeglumine-enhanced MR angiography

    International Nuclear Information System (INIS)

    Sardanelli, Francesco; Di Leo, Giovanni; Aliprandi, Alberto; Flor, Nicola; Papini, Giacomo D.E.; Roccatagliata, Luca; Cotticelli, Biagio; Nano, Giovanni; Cornalba, Gianpaolo

    2009-01-01

    Objectives: This study was aimed at testing the value of image subtraction for evaluating carotid vessel wall enhancement in contrast-enhanced MR angiography (MRA). Materials and methods: IRB approval was obtained. The scans of 81 consecutive patients who underwent carotid MRA with 0.1 mmol/kg of gadobenate dimeglumine were reviewed. Axial carotid 3D T1-weighted fast low-angle shot sequence before and 3 min after contrast injection were acquired and subtracted (enhanced minus unenhanced). Vessel wall enhancement was assigned a four-point score using native or subtracted images from 0 (no enhancement) to 3 (strong enhancement). Stenosis degree was graded according to NASCET. Results: With native images, vessel wall enhancement was detected in 20/81 patients (25%) and in 20/161 carotids (12%), and scored 2.0 ± 0.6 (mean ± standard deviation); with subtracted images, in 21/81 (26%) and 22/161 (14%), and scored 2.5 ± 0.6, respectively (P < 0.001, Sign test). The overall stenosis degree distribution was: mild, 41/161 (25%); moderate, 77/161 (48%); severe, 43/161 (27%). Carotids with moderate stenosis showed vessel wall enhancement with a frequency (17/77, 22%) significantly higher than that observed in carotids with mild stenosis (1/41, 2%) (P = 0.005, Fisher exact test) and higher, even though with borderline significance (P = 0.078, Fisher exact test), than that observed in carotids with severe stenosis (4/43, 9%). Conclusion: Roughly a quarter of patients undergoing carotid MRA showed vessel wall enhancement. Image subtraction improved vessel wall enhancement conspicuity. Vessel wall enhancement seems to be an event relatively independent from the degree of stenosis. Further studies are warranted to define the relation between vessel wall enhancement and histopathology, inflammatory status, and instability.

  16. Enhancement characteristics of retroperitoneal lymphomatous lymph nodes

    Energy Technology Data Exchange (ETDEWEB)

    Hagtvedt, Trond; Smith, Hans-Joergen; Kolbenstvedt, Alf [Dept. of Radiology and Nuclear Medicine, Oslo Univ. Hospital, Oslo (Norway); Faculty of Medicine, Univ. of Oslo, Oslo (Norway); Aaloekken, Trond Mogens [Dept. of Radiology and Nuclear Medicine, Oslo Univ. Hospital, Oslo (Norway)], e-mail: trond.mogens.aalokken@rikshospitalet.no; Graff, Bjoern Anton [Div. of Diagnostics, Vestre Viken Hospital Trust, Drammen (Norway); Kongsberg Hospital, Vestre Viken Hospital Trust, Drammen (Norway); Holte, Harald [Dept. of Oncology, Oslo Univ. Hospital, Oslo (Norway)

    2013-04-15

    Background: Previous studies of CT enhancement of lymphomatous lymph nodes (LLN) of the neck and the mediastinum showed that the LLN had lower enhancement values than normal lymph nodes. Purpose: To elucidate the contrast medium enhancement curves of LLN in the retroperitoneum by comparing the curves of LLN with those of normal lymph nodes, to test whether differences between these curves could be of diagnostic value, and to compare the present enhancement curves of LLN of the retroperitoneum with the curves of LLN of the neck and the mediastinum from previous similar investigations. Material and Methods: Twenty-eight consecutive patients with LLN of the retroperitoneum (three with Hodgkin's lymphoma [HL]) and 21 control patients with sarcomas and thus presumably normal retroperitoneal nodes underwent dynamic CT examinations. The previous, similar investigation of lymph nodes of the neck comprised 28 patients with LLN and the investigation of mediastinal lymph nodes comprised 24 patients with LLN. Results: The enhancement curves of the retroperitoneal LLN had significantly lower attenuation than those of the retroperitoneal control nodes. A combination of peak contrast value and time to peak adjusted to total body weight yielded a diagnostic accuracy which at the best showed a sensitivity of 90.5% with a specificity of 82.6%. The LLN of the retroperitoneum had higher attenuation values than corresponding nodes of the mediastinum but no significant difference was found between LLN of the retroperitoneum and LLN of the neck in previous similar investigations. Conclusion: The comparison of enhancement curves of retroperitoneal LLN with retroperitoneal control nodes showed a marked similarity with and substantiates our previous findings in lymph nodes of the neck and of the mediastinum. The best diagnostic accuracy was achieved by combining the parameters peak contrast value and time to peak and adjusting these values to the body weight. Peak enhancement of the

  17. Mechanisms of polyhalogenated biphenyl enhancement of endotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Hoglen, N.C.

    1993-01-01

    Polyhalogenated aromatic hydrocarbons (PHAHs) are a class of environmental contaminants that can produce a number of toxic responses. Many of their toxicities are thought to be mediated by a cytosolic receptor called the aryl hydrocarbon (Ah) receptor. Among the most toxic compounds in this class, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3,3[prime],4,4[prime]-tetrabromobiphenyl (TBB), have been shown to markedly increase the sensitivity of rodents to lipopolysaccharide (LPS)-mediated hepatotoxicity and lethality. The purpose of this study was to define what mechanisms are involved in PHAH-enhancement of endotoxicity and hepatotoxicity using TBB and a related PHAH, 3,3[prime],4,4[prime],5-pentachlorobiphenyl (PeCB). A number of findings were demonstrated. First, it was confirmed that TBB markedly enhanced LPS-mediated hepatotoxicity and lethality, and this enhancement was greatest when LPS was administered one day after the PHAH. In addition, the TBB markedly elevated peak serum activity of tumor necrosis factor (TNF), a cytotoxic cytokine produced by macrophages after LPS exposure. However, increased TNF after LPS was seen at all time points after TBB treatment. Dexamethasone blocked both increased TNF production and hepatotoxicity. PeCB also markedly enhanced LPS-mediated hepatotoxicity/lethality with similar increases in TNF. In addition to increasing TNF, it was demonstrated that PeCB could sensitize the liver to TNF hepatotoxicity. Studies using 3-methylcholanthrene (3MC), a compound that binds as avidly to the Ah receptor as the PeCB, found no enhancement of endotoxicity, suggesting that Ah receptor activation alone does not mediate PHAH enhancement. 3MC did, however, increase LPS-stimulated serum TNF levels. 2,2[prime],4,4[prime],5,5[prime]-Hexachlorobiphenyl, a PHAH that does not bind to the Ah receptor, did not enhance endotoxicity or TNF production.

  18. Exploring the chemical enhancement for surface-enhanced Raman scattering with Au bowtie nanoantennas

    International Nuclear Information System (INIS)

    Fromm, David P.; Sundaramurthy, Arvind; Kinkhabwala, Anika; Schuck, P. James; Kino, Gordon S.; Moerner, W.E.

    2006-01-01

    Single metallic bowtie nanoantennas provide a controllable environment for surface-enhanced Raman scattering (SERS) of adsorbed molecules. Bowties have experimentally measured electromagnetic enhancements, enabling estimation of chemical enhancement for both the bulk and the few-molecule regime. Strong fluctuations of selected Raman lines imply that a small number of p-mercaptoaniline molecules on a single bowtie show chemical enhancement >10 7 , much larger than previously believed, likely due to charge transfer between the Au surface and the molecule. This chemical sensitivity of SERS has significant implications for ultra-sensitive detection of single molecules

  19. Metal enhanced fluorescence with gold nanoparticles

    Science.gov (United States)

    Mattingly, Shaina LaRissa Strating

    A novel hybrid nanocomposite of Au nanoparticle-modified silicon nanowire was developed for surface enhanced fluorescence applications. The designed nanocomposite contained a silicon nanowire, gold nanoparticles and a silica layer doped with dye molecules. The hybrid nanomaterial was characterized using scanning electron microscopy (SEM), scanning transmission electron microscopy (STEM), fluorescence measurements, Fourier transform infrared (FT-IR) spectroscopy, and energy-dispersive X-ray spectroscopy (EDS). The results showed that the gold nanoparticles were uniformly adhered on the silicon nanowires and covered by a thin silica layer. The nanostructure exhibited strong capacity for surface enhanced fluorescence. Different enhancement factors were obtained by changing synthetic conditions. The second goal of the project was to determine if the shape of gold nanoparticles affects the extent of its fluorescence enhancement under constant external factors. Two shapes of gold nanoparticles were synthesized and characterized by SEM, STEM, zeta potential and absorbance measurements. Then they were coated with fluorescent dye-doped silica and the fluorescence intensity was measured and compared to the pure fluorescent dye. Gold nanorods enhanced fluorescence more than gold nanostars and that the fluorescent dye Alexafluor 700 showed a greater fluorescence intensity change in the presence of nanoparticles than methylene blue.

  20. A Framework for Reproducible Latent Fingerprint Enhancements.

    Science.gov (United States)

    Carasso, Alfred S

    2014-01-01

    Photoshop processing of latent fingerprints is the preferred methodology among law enforcement forensic experts, but that appproach is not fully reproducible and may lead to questionable enhancements. Alternative, independent, fully reproducible enhancements, using IDL Histogram Equalization and IDL Adaptive Histogram Equalization, can produce better-defined ridge structures, along with considerable background information. Applying a systematic slow motion smoothing procedure to such IDL enhancements, based on the rapid FFT solution of a Lévy stable fractional diffusion equation, can attenuate background detail while preserving ridge information. The resulting smoothed latent print enhancements are comparable to, but distinct from, forensic Photoshop images suitable for input into automated fingerprint identification systems, (AFIS). In addition, this progressive smoothing procedure can be reexamined by displaying the suite of progressively smoother IDL images. That suite can be stored, providing an audit trail that allows monitoring for possible loss of useful information, in transit to the user-selected optimal image. Such independent and fully reproducible enhancements provide a valuable frame of reference that may be helpful in informing, complementing, and possibly validating the forensic Photoshop methodology.

  1. Nanoantenna-Enhanced Infrared Spectroscopic Chemical Imaging.

    Science.gov (United States)

    Kühner, Lucca; Hentschel, Mario; Zschieschang, Ute; Klauk, Hagen; Vogt, Jochen; Huck, Christian; Giessen, Harald; Neubrech, Frank

    2017-05-26

    Spectroscopic infrared chemical imaging is ideally suited for label-free and spatially resolved characterization of molecular species, but often suffers from low infrared absorption cross sections. Here, we overcome this limitation by utilizing confined electromagnetic near-fields of resonantly excited plasmonic nanoantennas, which enhance the molecular absorption by orders of magnitude. In the experiments, we evaporate microstructured chemical patterns of C 60 and pentacene with nanometer thickness on top of homogeneous arrays of tailored nanoantennas. Broadband mid-infrared spectra containing plasmonic and vibrational information were acquired with diffraction-limited resolution using a two-dimensional focal plane array detector. Evaluating the enhanced infrared absorption at the respective frequencies, spatially resolved chemical images were obtained. In these chemical images, the microstructured chemical patterns are only visible if nanoantennas are used. This confirms the superior performance of our approach over conventional spectroscopic infrared imaging. In addition to the improved sensitivity, our technique provides chemical selectivity, which would not be available with plasmonic imaging that is based on refractive index sensing. To extend the accessible spectral bandwidth of nanoantenna-enhanced spectroscopic imaging, we employed nanostructures with dual-band resonances, providing broadband plasmonic enhancement and sensitivity. Our results demonstrate the potential of nanoantenna-enhanced spectroscopic infrared chemical imaging for spatially resolved characterization of organic layers with thicknesses of several nanometers. This is of potential interest for medical applications which are currently hampered by state-of-art infrared techniques, e.g., for distinguishing cancerous from healthy tissues.

  2. Resolution enhancement in second-derivative spectra.

    Science.gov (United States)

    Czarnecki, Mirosław A

    2015-01-01

    Derivative spectroscopy is a powerful tool for the resolution enhancement in infrared, near-infrared, Raman, ultraviolet-visible, nuclear magnetic resonance, electron paramagnetic resonance, and fluorescence spectroscopy. Despite its great significance in analytical chemistry, not all aspects of the applications of this method have been explored as yet. This is the first systematic study of the parameters that influence the resolution enhancement in the second derivative spectra. The derivative spectra were calculated with the Savitzky-Golay method with different window size (5, 15, 25) and polynomial order (2, 4). The results obtained in this work show that the resolution enhancement in the second derivative spectra strongly depends on the data spacing in the original spectra, window size, polynomial order, and peak profile. As shown, the resolution enhancement is related to variations in the width of the peaks upon the differentiation. The present study reveals that in order to maximize the separation of the peaks in the second derivative spectra, the original spectra should be recorded at high resolution and differentiated using a small window size and high polynomial order. However, working with the real spectra one has to compromise between the noise reduction and optimization of the resolution enhancement in the second derivative spectra.

  3. LSD enhances the emotional response to music.

    Science.gov (United States)

    Kaelen, M; Barrett, F S; Roseman, L; Lorenz, R; Family, N; Bolstridge, M; Curran, H V; Feilding, A; Nutt, D J; Carhart-Harris, R L

    2015-10-01

    There is renewed interest in the therapeutic potential of psychedelic drugs such as lysergic acid diethylamide (LSD). LSD was used extensively in the 1950s and 1960s as an adjunct in psychotherapy, reportedly enhancing emotionality. Music is an effective tool to evoke and study emotion and is considered an important element in psychedelic-assisted psychotherapy; however, the hypothesis that psychedelics enhance the emotional response to music has yet to be investigated in a modern placebo-controlled study. The present study sought to test the hypothesis that music-evoked emotions are enhanced under LSD. Ten healthy volunteers listened to five different tracks of instrumental music during each of two study days, a placebo day followed by an LSD day, separated by 5-7 days. Subjective ratings were completed after each music track and included a visual analogue scale (VAS) and the nine-item Geneva Emotional Music Scale (GEMS-9). Results demonstrated that the emotional response to music is enhanced by LSD, especially the emotions "wonder", "transcendence", "power" and "tenderness". These findings reinforce the long-held assumption that psychedelics enhance music-evoked emotion, and provide tentative and indirect support for the notion that this effect can be harnessed in the context of psychedelic-assisted psychotherapy. Further research is required to test this link directly.

  4. Evaluation of the early enhancement of coronary atherosclerotic plaque by contrast-enhanced MR angiography

    Energy Technology Data Exchange (ETDEWEB)

    Li Tao [Department of Radiology, The General Hospital of Chinese People' s Armed Police Forces, Number 69, Yong Ding Road, Hai Dian District, Beijing (China); Department of Radiology, Chinese People' s Liberation Army General Hospital, Number 28, Fu Xing Road, Hai Dian District, Beijing (China); Zhao Xihai [Department of Radiology, Chinese People' s Liberation Army General Hospital, Number 28, Fu Xing Road, Hai Dian District, Beijing (China); Liu Xin [Paul C. Lauterbur Biomedical Imaging Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518067 (China); Gao Jianhua [Department of Radiology, The General Hospital of Chinese People' s Armed Police Forces, Number 69, Yong Ding Road, Hai Dian District, Beijing (China); Zhao Shaohong [Department of Radiology, Chinese People' s Liberation Army General Hospital, Number 28, Fu Xing Road, Hai Dian District, Beijing (China); Li Xin; Zhou Weihua [Department of Radiology, The General Hospital of Chinese People' s Armed Police Forces, Number 69, Yong Ding Road, Hai Dian District, Beijing (China); Cai Zulong [Department of Radiology, Chinese People' s Liberation Army General Hospital, Number 28, Fu Xing Road, Hai Dian District, Beijing (China); Zhang Weiguo [Cardiovascular and Neurological Consulting Institute, 6771 San Fernando, Irving, TX 75039 (United States); Yang Li, E-mail: Yangli301@yahoo.com [Department of Radiology, Chinese People' s Liberation Army General Hospital, Number 28, Fu Xing Road, Hai Dian District, Beijing (China)

    2011-10-15

    Purpose: To evaluate the early enhancement of coronary atherosclerotic plaque using contrast-enhanced MR angiography (CE-MRA) and investigate the association between unstable angina pectoris (UAP) and early enhancement of the plaque. Methods: Forty-one patients presenting with angina pectoris and demonstrating single-vessel disease with non-calcified plaque and significant coronary stenosis ({>=}50%) on CTA were consecutively recruited for coronary CE-MRA. Contrast-to-noise ratio of the culprit plaque guided by CTA was measured on a cross-sectional multi-planar reconstruction image of the plaque on both pre- and post-CE-MRA. A 50% increasing of CNR was defined as plaque enhancement. The association between early enhancement of the plaques and UAP was analyzed. Results: Thirty-seven non-calcified plaques with significant coronary stenosis were detected in the 37 patients on MRA. 4 subjects were excluded because coronary atherosclerotic plaques were inadequate for identification on MRA. Of the 37 patients, 18 patients had UAP and other 19 patients presented stable angina pectoris (SAP). Of the 37 plaques on CE-MRA, 13 and 24 plaques presented early enhancement and no enhancement, respectively. Of the 13 early-enhanced plaques, 11 (85%) and 2 (15%) were found in the patients with UAP and SAP, respectively (p < 0.01). Of the 37 patients, 11 (61%) with UAP and 2 (11%) with SAP had early-enhanced plaques, respectively (p < 0.01). Conclusion: CE-MRA allows detection of early enhancement of coronary atherosclerotic plaque. The early enhancement is common in unstable angina and could be a sign of vulnerability.

  5. Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state

    Directory of Open Access Journals (Sweden)

    Ahmed El-Badawy

    2017-11-01

    Full Text Available Abstract Background Mesenchymal stem cells (MSCs play different roles in modulating tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large numbers and subsequently have an important microenvironmental role in modulating tumor progression and drug sensitivity. However, the effect of the tumor microenvironment on MSC plasticity remains poorly understood. Herein, we report a paracrine effect of cancer cells, in which they secrete soluble factors that promote a more stem-like state in bone marrow mesenchymal stem cells (BM-MSCs. Methods The effect of soluble factors secreted from MCF7, Hela, and HepG2 cancer cell lines on BM-MSCs was assessed using a Transwell indirect coculture system. After 5 days of coculture, BM-MSCs were characterized by flow cytometry for surface marker expression, by qPCR for gene expression profile, and by confocal immunofluorescence for marker expression. We then measured the sensitivity of cocultured BM-MSCs to chemotherapeutic agents, their cell cycle profile, and their response to DNA damage. The sphere formation, invasive properties, and in-vivo performance of BM-MSCs after coculture with cancer cells were also measured. Results Indirect coculture of cancer cells and BM-MSCs, without direct cell contact, generated slow cycling, chemoresistant spheroid stem cells that highly expressed markers of pluripotency, cancer cells, and cancer stem cells (CSCs. They also displayed properties of a side population and enhanced sphere formation in culture. Accordingly, these cells were termed cancer-induced stem cells (CiSCs. CiSCs showed a more mesenchymal phenotype that was further augmented upon TGF-β stimulation and demonstrated a high expression of the β-catenin pathway and ALDH1A1. Conclusions These findings demonstrate that MSCs, recruited to the tumor microenvironment in large numbers, may display cellular plasticity, acquire a more stem-like state, and acquire some properties of CSCs upon

  6. Tax incentives and enhanced oil recovery techniques

    International Nuclear Information System (INIS)

    Stathis, J.S.

    1991-05-01

    Tax expenditures-reductions in income tax liability resulting from a special tax provision-are often used to achieve economic and social objectives. The arguments for petroleum production tax incentives usually encompass some combination of enhancing energy security, rewarding risk, or generating additional investment in new technologies. Generally, however, some portion of any tax expenditure is spend on activities that would have occurred anyway. This paper is a review of tax incentives for petroleum production found two to be of questionable merit. Others, including tax preferences for enhanced oil recovery methods, which offered the potential for better returns on the tax dollar. Increased use of enhanced oil recovery techniques could lead to additional environmental costs, however, and these need to be factored into any cost-benefit calculation

  7. Lightning enhancement over major oceanic shipping lanes

    Science.gov (United States)

    Thornton, Joel A.; Virts, Katrina S.; Holzworth, Robert H.; Mitchell, Todd P.

    2017-09-01

    Using 12 years of high-resolution global lightning stroke data from the World Wide Lightning Location Network (WWLLN), we show that lightning density is enhanced by up to a factor of 2 directly over shipping lanes in the northeastern Indian Ocean and the South China Sea as compared to adjacent areas with similar climatological characteristics. The lightning enhancement is most prominent during the convectively active season, November-April for the Indian Ocean and April-December in the South China Sea, and has been detectable from at least 2005 to the present. We hypothesize that emissions of aerosol particles and precursors by maritime vessel traffic lead to a microphysical enhancement of convection and storm electrification in the region of the shipping lanes. These persistent localized anthropogenic perturbations to otherwise clean regions are a unique opportunity to more thoroughly understand the sensitivity of maritime deep convection and lightning to aerosol particles.

  8. Enhanced index tracking modelling in portfolio optimization

    Science.gov (United States)

    Lam, W. S.; Hj. Jaaman, Saiful Hafizah; Ismail, Hamizun bin

    2013-09-01

    Enhanced index tracking is a popular form of passive fund management in stock market. It is a dual-objective optimization problem, a trade-off between maximizing the mean return and minimizing the risk. Enhanced index tracking aims to generate excess return over the return achieved by the index without purchasing all of the stocks that make up the index by establishing an optimal portfolio. The objective of this study is to determine the optimal portfolio composition and performance by using weighted model in enhanced index tracking. Weighted model focuses on the trade-off between the excess return and the risk. The results of this study show that the optimal portfolio for the weighted model is able to outperform the Malaysia market index which is Kuala Lumpur Composite Index because of higher mean return and lower risk without purchasing all the stocks in the market index.

  9. BIR 2014 - Bibliometric-enhanced Information Retrieval

    DEFF Research Database (Denmark)

    This first “Bibliometric-enhanced Information Retrieval” (BIR 2014) workshop1 aims to engage with the IR community about possible links to bibliometrics and scholarly communication. Bibliometric techniques are not yet widely used to enhance retrieval processes in digital libraries, although...... analysis of co-authorship network, can improve retrieval services for specific communities, as well as for large, cross-domain collections. This workshop aims to raise awareness of the missing link between information retrieval (IR) and bibliometrics / scientometrics and to create a common ground...... for the incorporation of bibliometric-enhanced services into retrieval at the digital library interface. Our interests include information retrieval, information seeking, science modelling, network analysis, and digital libraries. The goal is to apply insights from bibliometrics, scientometrics, and informetrics...

  10. Enhancements in the thorp reprocessing plant

    International Nuclear Information System (INIS)

    Wakem, M.J.; Brownridge, M.

    2000-01-01

    A number of successful enhancements have been made to the process at the Thorp reprocessing plant at Sellafield. After a long and detailed Research and Development programme followed by an intensive design/construction project, Thorp was inactively commissioned with first active shear in March 1994. The plant has now reached a mature stage in its development, following successful active commissioning demonstrating flowsheet or better performance in the solvent extraction cycles. Enhancements are now sought to achieve a range of objectives. Against a background of ever tighter regulatory control both in terms of safety and environmental discharge, BNFL are continuing to invest in further improvements with short, medium and longer term objectives to improve plant throughput; expand the range of feed fuels; reduce environmental discharges and reduce running costs. This paper describes a few of these enhancements. (authors)

  11. Subthreshold olfactory stimulation can enhance sweetness.

    Science.gov (United States)

    Labbe, D; Rytz, A; Morgenegg, C; Ali, S; Martin, N

    2007-03-01

    The impact of olfactory perception on sweetness was explored in a model solution using odorants at subthreshold concentrations. First, the impact of 6 odorants, previously described in the literature as congruent with sweetness, was investigated at suprathreshold level in a sucrose solution. Ethyl butyrate and maltol were selected as they had the highest and the lowest sweetness-enhancing properties, respectively. Second, the impact on sweetness of the 2 odorants was investigated at subthreshold concentrations. A system delivering a continuous liquid flow at the same sucrose level, but with varying odorant concentrations, was used. At a subthreshold level, ethyl butyrate but not maltol significantly enhanced the sweetness of the sucrose solution. This study highlights that olfactory perception induced by odorants at a subthreshold level can significantly modulate taste perception. Finally, contrary to results observed with ethyl butyrate at suprathreshold levels, at subthreshold levels, the intensity of sweetness enhancement was not proportional to ethyl butyrate concentration.

  12. Caffeine and taurine enhance endurance performance.

    Science.gov (United States)

    Imagawa, T F; Hirano, I; Utsuki, K; Horie, M; Naka, A; Matsumoto, K; Imagawa, S

    2009-07-01

    Caffeine enhances endurance performance; however, its effect on accumulated lactate remains unclear. Conversely, taurine, which also enhances endurance performance, decreases accumulated lactate. In this study, the effect of combination of caffeine and taurine on endurance performance was assessed. Mice ran on a treadmill, and the accumulated lactate was measured. In addition, muscle fibers from the gastrocnemius muscle of the mice were stained with ATPase and analyzed. The use of caffeine and taurine over a 2 week period enhanced endurance performance. Moreover, taurine significantly decreased the accumulated concentration of lactate over long running distances. However, the diameter of the cross-sections and ratios of Types I, IIA, and IIB muscle fibers were not affected.

  13. Contrast-enhanced harmonic endoscopic ultrasound

    DEFF Research Database (Denmark)

    Săftoiu, A; Dietrich, C F; Vilmann, P

    2012-01-01

    Second-generation intravenous blood-pool ultrasound contrast agents are increasingly used in endoscopic ultrasound (EUS) for characterization of microvascularization, differential diagnosis of benign and malignant focal lesions, and improving staging and guidance of therapeutic procedures. Although...... initially used as Doppler signal enhancers, second-generation microbubble contrast agents are now used with specific contrast harmonic imaging techniques, which benefit from the highly nonlinear behavior of the microbubbles. Contrast-specific modes based on multi-pulse technology are used to perform...... contrast-enhanced harmonic EUS based on a very low mechanical index (0.08 - 0.12). Quantification techniques based on dynamic contrast-enhanced ultrasound have been recommended for perfusion imaging and monitoring of anti-angiogenic treatment, mainly based on time-intensity curve analysis. Most...

  14. Acquirement and enhancement of remote speech signals

    Science.gov (United States)

    Lü, Tao; Guo, Jin; Zhang, He-yong; Yan, Chun-hui; Wang, Can-jin

    2017-07-01

    To address the challenges of non-cooperative and remote acoustic detection, an all-fiber laser Doppler vibrometer (LDV) is established. The all-fiber LDV system can offer the advantages of smaller size, lightweight design and robust structure, hence it is a better fit for remote speech detection. In order to improve the performance and the efficiency of LDV for long-range hearing, the speech enhancement technology based on optimally modified log-spectral amplitude (OM-LSA) algorithm is used. The experimental results show that the comprehensible speech signals within the range of 150 m can be obtained by the proposed LDV. The signal-to-noise ratio ( SNR) and mean opinion score ( MOS) of the LDV speech signal can be increased by 100% and 27%, respectively, by using the speech enhancement technology. This all-fiber LDV, which combines the speech enhancement technology, can meet the practical demand in engineering.

  15. Cavity-Enhanced Transport of Charge

    Science.gov (United States)

    Hagenmüller, David; Schachenmayer, Johannes; Schütz, Stefan; Genes, Claudiu; Pupillo, Guido

    2017-12-01

    We theoretically investigate charge transport through electronic bands of a mesoscopic one-dimensional system, where interband transitions are coupled to a confined cavity mode, initially prepared close to its vacuum. This coupling leads to light-matter hybridization where the dressed fermionic bands interact via absorption and emission of dressed cavity photons. Using a self-consistent nonequilibrium Green's function method, we compute electronic transmissions and cavity photon spectra and demonstrate how light-matter coupling can lead to an enhancement of charge conductivity in the steady state. We find that depending on cavity loss rate, electronic bandwidth, and coupling strength, the dynamics involves either an individual or a collective response of Bloch states, and we explain how this affects the current enhancement. We show that the charge conductivity enhancement can reach orders of magnitudes under experimentally relevant conditions.

  16. Enhancer RNAs and regulated transcriptional programs.

    Science.gov (United States)

    Lam, Michael T Y; Li, Wenbo; Rosenfeld, Michael G; Glass, Christopher K

    2014-04-01

    A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (lncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional activators and repressors. More recently, enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Here, we review emerging evidence suggesting that at least some eRNAs contribute to enhancer function. We discuss these findings with respect to potential mechanisms of action of eRNAs and other ncRNAs in regulated gene expression. Copyright © 2014. Published by Elsevier Ltd.

  17. Biomoral Enhancement. Definizioni e problemi aperti

    Directory of Open Access Journals (Sweden)

    Luca Lo Sapio

    2014-12-01

    Full Text Available This paper focuses on the important disputation about biomoral enhancement, the new frontier of human enhancement international debate. In the first part, it analyses the main issues of Unfit for the future, the 2012 book of Savulescu and Persson, which represents a very relevant step within this theme. In the second part, it considers some arguments against Persson and Savulescu’s thesis and their own replies. Finally, it develops some arguments to show the difficulties related to the idea that it is possible to clearly understand the nature of a moral enhancement and point out the hurdle to circumscribe the basic elements we have to intervene on in order to obtain a real improvement of human moral attitudes.

  18. A Confucian reflection on genetic enhancement.

    Science.gov (United States)

    Fan, Ruiping

    2010-04-01

    This essay explores a proper Confucian vision on genetic enhancement. It argues that while Confucians can accept a formal starting point that Michael Sandel proposes in his ethics of giftedness, namely, that children should be taken as gifts, Confucians cannot adopt his generalist strategy. The essay provides a Confucian full ethics of giftedness by addressing a series of relevant questions, such as what kind of gifts children are, where the gifts are from, in which way they are given, and for what purpose they are given. It indicates that Confucians should sort out different types of enhancement and bring them to the test of the Confucian values in terms of both Confucian virtue principles and specific ritual rules. It concludes that Confucians can accept some types of enhancement but must reject others.

  19. Enhancement stimulants: perceived motivational and cognitive advantages

    Directory of Open Access Journals (Sweden)

    Irena P. Ilieva

    2013-10-01

    Full Text Available Psychostimulants like Adderall and Ritalin are widely used for cognitive enhancement by people without ADHD, although the empirical literature has shown little conclusive evidence for effectiveness in this population. This paper explores one potential explanation of this discrepancy: the possibility that the benefit from enhancement stimulants is at least in part motivational, rather than purely cognitive. We review relevant laboratory, survey and interview research and present the results of a new survey of enhancement users with the goal of comparing perceived cognitive and motivational effects. These users perceived stimulant effects on motivationally-related factors, especially energy and motivation, and reported motivational effects to be at least as pronounced as cognitive effects, including effects on "attention."

  20. Enhancement stimulants: perceived motivational and cognitive advantages.

    Science.gov (United States)

    Ilieva, Irena P; Farah, Martha J

    2013-01-01

    Psychostimulants like Adderall and Ritalin are widely used for cognitive enhancement by people without ADHD, although the empirical literature has shown little conclusive evidence for effectiveness in this population. This paper explores one potential explanation of this discrepancy: the possibility that the benefit from enhancement stimulants is at least in part motivational, rather than purely cognitive. We review relevant laboratory, survey, and interview research and present the results of a new survey of enhancement users with the goal of comparing perceived cognitive and motivational effects. These users perceived stimulant effects on motivationally-related factors, especially "energy" and "motivation," and reported motivational effects to be at least as pronounced as cognitive effects, including the effects on "attention."

  1. Fast mutual-information-based contrast enhancement

    Science.gov (United States)

    Cao, Gang; Yu, Lifang; Tian, Huawei; Huang, Xianglin; Wang, Yongbin

    2017-07-01

    Recently, T. Celik proposed an effective image contrast enhancement (CE) method based on spatial mutual information and PageRank (SMIRANK). According to the state-of-the-art evaluation criteria, it achieves the best visual enhancement quality among existing global CE methods. However, SMIRANK runs much slower than the other counterparts, such as histogram equalization (HE) and adaptive gamma correction. Low computational complexity is also required for good CE algorithms. In this paper, we novelly propose a fast SMIRANK algorithm, called FastSMIRANK. It integrates both spatial and gray-level downsampling into the generation of pixel value mapping function. Moreover, the computation of rank vectors is speeded up by replacing PageRank with a simple yet efficient row-based operation of mutual information matrix. Extensive experimental results show that the proposed FastSMIRANK could accelerate the processing speed of SMIRANK by about 20 times, and is even faster than HE. Comparable enhancement quality is preserved simultaneously.

  2. Enhancing placebo effects: insights from social psychology.

    Science.gov (United States)

    Sliwinski, Jim; Elkins, Gary R

    2013-01-01

    Placebo effects are widely recognized as having a potent impact upon treatment outcomes in both medical and psychological interventions, including hypnosis. In research utilizing randomized clinical trials, there is usually an effort to minimize or control placebo effects. However, in clinical practice there may be significant benefits in enhancing placebo effects. Prior research from the field of social psychology has identified three factors that may enhance placebo effects, namely: priming, client perceptions, and the theory of planned behavior. These factors are reviewed and illustrated via a case example. The consideration of social-psychological factors to enhance positive expectancies and beliefs has implications for clinical practice as well as future research into hypnotic interventions.

  3. Signal Enhancement with Variable Span Linear Filters

    DEFF Research Database (Denmark)

    Benesty, Jacob; Christensen, Mads Græsbøll; Jensen, Jesper Rindom

    This book introduces readers to the novel concept of variable span speech enhancement filters, and demonstrates how it can be used for effective noise reduction in various ways. Further, the book provides the accompanying Matlab code, allowing readers to easily implement the main ideas discussed....... Variable span filters combine the ideas of optimal linear filters with those of subspace methods, as they involve the joint diagonalization of the correlation matrices of the desired signal and the noise. The book shows how some well-known filter designs, e.g. the minimum distortion, maximum signal......-to-noise ratio, Wiener, and tradeoff filters (including their new generalizations) can be obtained using the variable span filter framework. It then illustrates how the variable span filters can be applied in various contexts, namely in single-channel STFT-based enhancement, in multichannel enhancement in both...

  4. Hermetic compartments leak-tightness enhancement

    International Nuclear Information System (INIS)

    Murani, J.

    2000-01-01

    In connection with the enhancement of the nuclear safety of the Jaslovske Bohunice V-1 NPP actions for the increase of the leak tightness are performed. The reconstruction has been done in the following directions: hermetic compartments leak tightness enhancement; air lock installation; installation of air lock in SP 4 vent system; integrated leakage rate test to hermetic compartments with leak detection. After 'major' leaks on the hermetic boundary components had been eliminated, since 1994 works on a higher qualitative level began. The essence of the works consists in the detection and identification of leaks in the structural component of the hermetic boundary during the planned refueling outages. The results of the Small Reconstruction and gradual enhancement of leak tightness are presented

  5. Magnetically-enhanced open string pair production

    Science.gov (United States)

    Lu, J. X.

    2017-12-01

    We consider the stringy interaction between two parallel stacks of D3 branes placed at a separation. Each stack of D3 branes in a similar fashion carry an electric flux and a magnetic flux with the two sharing no common field strength index. The interaction amplitude has an imaginary part, giving rise to the Schwinger-like pair production of open strings. We find a significantly enhanced rate of this production when the two electric fluxes are almost identical and the brane separation is on the order of string scale. This enhancement will be largest if the two magnetic fluxes are opposite in direction. This novel enhancement results from the interplay of the non-perturbative Schwinger-type pair production due to the electric flux and the stringy tachyon due to the magnetic flux, and may have realistic physical applications.

  6. Dengue virus antibodies enhance Zika virus infection.

    Science.gov (United States)

    Paul, Lauren M; Carlin, Eric R; Jenkins, Meagan M; Tan, Amanda L; Barcellona, Carolyn M; Nicholson, Cindo O; Michael, Scott F; Isern, Sharon

    2016-12-01

    For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases. Recent reports of severe disease associated with ZIKV have greatly heightened awareness. It is anticipated that ZIKV will continue to spread in the Americas and globally where competent Aedes mosquito vectors are found. Dengue virus (DENV), the most common mosquito-transmitted human flavivirus, is both well-established and the source of outbreaks in areas of recent ZIKV introduction. DENV and ZIKV are closely related, resulting in substantial antigenic overlap. Through antibody-dependent enhancement (ADE), anti-DENV antibodies can enhance the infectivity of DENV for certain classes of immune cells, causing increased viral production that correlates with severe disease outcomes. Similarly, ZIKV has been shown to undergo ADE in response to antibodies generated by other flaviviruses. We tested the neutralizing and enhancing potential of well-characterized broadly neutralizing human anti-DENV monoclonal antibodies (HMAbs) and human DENV immune sera against ZIKV using neutralization and ADE assays. We show that anti-DENV HMAbs, cross-react, do not neutralize, and greatly enhance ZIKV infection in vitro . DENV immune sera had varying degrees of neutralization against ZIKV and similarly enhanced ZIKV infection. Our results suggest that pre-existing DENV immunity may enhance ZIKV infection in vivo and may lead to increased disease severity. Understanding the interplay between ZIKV and DENV will be critical in informing public health responses and will be particularly valuable for ZIKV and DENV vaccine design and implementation strategies.

  7. Potential of Bio-Enhanced DNAPL Dissolution

    Science.gov (United States)

    Chu, J. M.; Kitanidis, P. K.; McCarty, P. L.

    2006-12-01

    DNAPL contamination is one of most challenging environmental problems. According to EPA's estimation, the total number of dense non-aqueous phase liquid (DNAPL) impacted sites in the U.S. could range from 15,000 to 25,000. It has been generally believed that promoting biological reactions that transform contaminants in DNAPL source zones can increase mass transfer rates, thereby shortening source longevity and total cleanup time. Use of bioremediation to enhance residual DNAPL dissolution, therefore, has potential as an economical and effective approach to accelerate DNAPL cleanup. While promising, some biological processes, such as biomass growth and gas production (CO2 and CH4), may occur together with biodegradation in source zones and adversely affect dissolution enhancement. In addition, the toxic effects of DNAPL compounds and transformation products produced by microorganisms may also adversely affect microbial activity and the extent of the bio-active zones. An understanding of how such factors control the efficiency of bio-enhanced dissolution is of great importance in helping to predict the potential benefits of DNAPL bioremediation. In this presentation, we will integrate the results of experimental and theoretical studies over the past six years on bio-enhanced tetrachloroethene (PCE) DNAPL dissolution to illustrate the effects on dissolution enhancement. Specifically, we will discuss the significance of our theoretical work on: (1) how biomass accumulation can affect dissolution enhancement for a PCE DNAPL pool and (2) the evolution of a bio-active zone in a residual DNAPL area under the influence of DNAPL toxicity. In addition, we will show the interplay between various groups of microorganisms within and around PCE DNAPL source zones as well as how our experimental work can help better understand the toxic effects of PCE and its transformation products on the activity of PCE dehalogenating bacteria. Finally, the presentation will highlight

  8. LSD enhances suggestibility in healthy volunteers.

    Science.gov (United States)

    Carhart-Harris, R L; Kaelen, M; Whalley, M G; Bolstridge, M; Feilding, A; Nutt, D J

    2015-02-01

    Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control. The present study sought to test the effect of LSD on suggestibility in a modern research study. Ten healthy volunteers were administered with intravenous (i.v.) LSD (40-80 μg) in a within-subject placebo-controlled design. Suggestibility and cued mental imagery were assessed using the Creative Imagination Scale (CIS) and a mental imagery test (MIT). CIS and MIT items were split into two versions (A and B), balanced for 'efficacy' (i.e. A ≈ B) and counterbalanced across conditions (i.e. 50 % completed version 'A' under LSD). The MIT and CIS were issued 110 and 140 min, respectively, post-infusion, corresponding with the peak drug effects. Volunteers gave significantly higher ratings for the CIS (p = 0.018), but not the MIT (p = 0.11), after LSD than placebo. The magnitude of suggestibility enhancement under LSD was positively correlated with trait conscientiousness measured at baseline (p = 0.0005). These results imply that the influence of suggestion is enhanced by LSD. Enhanced suggestibility under LSD may have implications for its use as an adjunct to psychotherapy, where suggestibility plays a major role. That cued imagery was unaffected by LSD implies that suggestions must be of a sufficient duration and level of detail to be enhanced by the drug. The results also imply that individuals with high trait conscientiousness are especially sensitive to the suggestibility-enhancing effects of LSD.

  9. A Comparative Study of Histogram Equalization Based Image Enhancement Techniques for Brightness Preservation and Contrast Enhancement

    OpenAIRE

    Patel, Omprakash; Maravi, Yogendra P. S.; Sharma, Sanjeev

    2013-01-01

    Histogram Equalization is a contrast enhancement te chnique in the image processing which uses the histogram of image. However histogram equalization is not the best method for contrast enhancement because the mean brightness of the output image is significantly different from the input image. There are several extensions of histogram equalization has be en proposed to overcome the brightness preservation cha...

  10. DEMAND FOR ENHANCED FOODS AND THE VALUE OF NUTRITIONAL ENHANCEMENTS OF FOOD: THE CASE OF MARGARINES

    OpenAIRE

    Huffman, Sonya Kostova; Jensen, Helen H.

    2004-01-01

    This paper evaluates consumer preferences and choice of nutritionally enhanced food products based on economic, geographic, ethnic and other socioeconomic characteristics. Household scanner data allow estimation of hedonic price function and a probit model on the choice of margarine that promotes good health. The empirical estimation established a positive value for nutritional enhancement.

  11. Public opinions about human enhancement can enhance the expert-only debate. A review study

    NARCIS (Netherlands)

    Dijkstra, Anne M.; Schuijff, Mirjam

    2016-01-01

    Human enhancement, the non-medical use of biomedical technologies to improve the human body or performance beyond their ‘natural’ limitations, is a growing trend. At the same time, the use of these technologies has societal consequences. In societal debates about human enhancement, however, it is

  12. Enhancing Leadership Quality. TQ Source Tips & Tools: Emerging Strategies to Enhance Educator Quality

    Science.gov (United States)

    National Comprehensive Center for Teacher Quality, 2008

    2008-01-01

    Teaching Quality (TQ) Source Tips & Tools: Emerging Strategies to Enhance Educator Quality is an online resource developed by the TQ Center. It is designed to help education practitioners tap into strategies and resources they can use to enhance educator quality. This publication is based on the TQ Source Tips & Tools topic area "Enhancing…

  13. Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation.

    Science.gov (United States)

    Chen, Hongjun; Du, Guangshi; Song, Xu; Li, Ling

    2017-06-01

    Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression. Copyright © 2017 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. Production and hosting by Elsevier B.V. All rights reserved.

  14. Memory enhancing drugs and Alzheimer's disease: enhancing the self or preventing the loss of it?

    NARCIS (Netherlands)

    Dekkers, W.J.M.; Olde Rikkert, M.G.M.

    2007-01-01

    In this paper we analyse some ethical and philosophical questions related to the development of memory enhancing drugs (MEDs) and anti-dementia drugs. The world of memory enhancement is coloured by utopian thinking and by the desire for quicker, sharper, and more reliable memories. Dementia is

  15. Fluorescence enhancement of modified silver nanoparticles.

    Science.gov (United States)

    Liu, Meicen; Zhang, Zhenglong; Liu, Gaining; Dong, Jun; Sun, Yu; Zheng, Hairong; Li, Guian

    2011-11-01

    Surface enhanced fluorescence (SEF) effect of acridine orange fluorophore in the proximity of silver nanoparticles (NPs) has been investigated experimentally in the aqueous solution system. It was found that the SEF effect could be influenced by the distribution of the NPs and the separation between the fluorophore molecule and metal surface. The fluorescence enhancement was improved significantly when Ag NPs was capped with 4-Aminothiophenol (PATP) that was acted as an isolating layer between the metal surface and fluorophore molecules. The results suggest that a proper distribution of metallic NPs and proper separation between fluorophore molecule and the particle surface are important for obtaining an optimal SEF effect.

  16. Interpretation techniques. [image enhancement and pattern recognition

    Science.gov (United States)

    Dragg, J. L.

    1974-01-01

    The image enhancement and geometric correction and registration techniques developed and/or demonstrated on ERTS data are relatively mature and greatly enhance the utility of the data for a large variety of users. Pattern recognition was improved by the use of signature extension, feature extension, and other classification techniques. Many of these techniques need to be developed and generalized to become operationally useful. Advancements in the mass precision processing of ERTS were demonstrated, providing the hope for future earth resources data to be provided in a more readily usable state. Also in evidence is an increasing and healthy interaction between the techniques developers and the user/applications investigators.

  17. Post-traumatic contrast enhancing brain lesion

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Jung; Kim, Hyun Sook; Jeong, Min Sun; Kim, Deok Ryeong; Cho, Young Kwon; Choi, Yun Sun [Eulji Hospital, Eulji University College of Medicine, Seoul (Korea, Republic of)

    2014-10-15

    Only a few studies have been reported on the MR contrast enhancement and the apparent diffusion coefficient (ADC) findings of the post-traumatic lesion of the brain. We report a case of the venous ischemia in the left frontal lobe observed in the MRI obtained one day after the incidence of trauma. Considering the presented slight increase in the ADC, the vasogenic edema was thought to be the major mechanism of the venous ischemia and excitotoxic injury. In spite of a slight increase in the ADC, the hyperintensity in the diffusion weighted imaging and contrast-enhanced areas eventually changed into hemorrhagic lesions.

  18. Enhanced Nonlinear Effects in Metamaterials and Plasmonics

    Directory of Open Access Journals (Sweden)

    C. Argyropoulos

    2012-07-01

    Full Text Available In this paper we provide an overview of the anomalous and enhanced nonlinear effects available when optical nonlinear materials are combined inside plasmonic waveguide structures. Broad, bistable and all-optical switching responses are exhibited at the cut-off frequency of these waveguides, characterized by reduced Q-factor resonances. These phenomena are due to the large field enhancement obtained inside specific plasmonic gratings, which ensures a significant boosting of the nonlinear operation. Several exciting applications are proposed, which may potentially lead to new optical components and add to the optical nanocircuit paradigm.

  19. Emission enhancement within gold spherical nanocavity arrays.

    Science.gov (United States)

    Jose, Bincy; Steffen, Ronald; Neugebauer, Ute; Sheridan, Eoin; Marthi, Reena; Forster, Robert J; Keyes, Tia E

    2009-12-14

    Gold nanocavity arrays were prepared on fluorine-doped tin oxide on glass by electrochemical deposition of gold through monolayers of polystyrene spheres. The impact of the resulting spherical cap architecture on the photophysics of solutions and self-assembled monolayers of luminophore encapsulated within the nanocavities is reported for the first time. From conventional confocal fluorescence microscopy, the emission intensity of solutions of [Ru(bpy)(2)(Qbpy)](2+) (where bpy is 2,2'-bipyridyl and Qbpy is 2,2':4,4'':4,4''-quarterpyridyl) and fullerene (C(60)) encapsulated within the 820 nm diameter nanocavities was demonstrated to increase by approximately an order of magnitude compared with that of the associated bulk solution. Comparison was also made with the emission observed for luminophore solution encapsulated in cobalt nanocavities of comparable dimensions, where plasmonic interactions are not anticipated. Again, approximately an order of magnitude enhancement was observed for the gold arrays. Luminescence lifetime imaging revealed that the enhancement of the emission intensity of this solution within the nanocavity was accompanied by a small but significant decrease in the luminescent lifetime for [Ru(bpy)(2)(Qbpy)](2+). Enhancement was, in addition, strongly influenced by the wavelength of excitation, suggesting that plasmonics may play a role in the enhancement of the excitation process. An important observation from confocal imaging studies was that the dimensions of the luminophore emission field from solution within the cavities were significantly smaller than the dimensions of the cavity aperture and corresponded to a little more than that of the point spread function of the microscope. This indicates that its origin is significantly smaller than the wavelength of the emitted light and suggests that luminescence enhancement is highly localised. When the array was filled with a solution of [Ru(bpy)(2)(Qbpy)](2+) the emission spectrum of this complex

  20. Human fine body hair enhances ectoparasite detection.

    Science.gov (United States)

    Dean, Isabelle; Siva-Jothy, Michael T

    2012-06-23

    Although we are relatively naked in comparison with other primates, the human body is covered in a layer of fine hair (vellus and terminal hair) at a relatively high follicular density. There are relatively few explanations for the evolutionary maintenance of this type of human hair. Here, we experimentally test the hypothesis that human fine body hair plays a defensive function against ectoparasites (bed bugs). Our results show that fine body hair enhances the detection of ectoparasites through the combined effects of (i) increasing the parasite's search time and (ii) enhancing its detection.

  1. Mechanically enhanced electrospun nanofibers for wastewater treatment

    Science.gov (United States)

    Yalcinkaya, Fatma

    2017-11-01

    A novel high-performance polyamide 6, polyacrylonitrile and polyvinylidene fluoride nanofibers were fabricated using industrial production Nanospider equipment for liquid filtration as microfilters. The application of nanofibers has been hindered by their poor mechanical strength. This work developed a feasible approach to preparing mechanically strong nanofiber webs. The mechanical strength of the nanofibers was enhanced using special lamination technique on a supporting layer. Experimental results show that the mechanical strength of the nanofibers enhanced more than 5 times while high porosity and liquid permeability retain. The separation results indicate that nanofibers have a potential to be used in liquid filters.

  2. Buildings with enhanced radioactivity in Sweden

    International Nuclear Information System (INIS)

    Swedjemark, G.A.

    1980-12-01

    Enhanced radon/radon daughter concentrations indoors have been found in some houses in Sweden, especially in combination with low air exchange rates. The radon sources have been found to be some types of building materials, some types of filling materials, some types of ground and any combination of these sources. The radon source may also be radon-rich tap water. The same types of building materials also give an enhanced gamma radiation level. In all houses, both lower and higher concentrations of radon than the average levels given here have been found in individual rooms and with single measurements. (author)

  3. Absorption enhancement in graphene photonic crystal structures.

    Science.gov (United States)

    Khaleque, Abdul; Hattori, Haroldo T

    2016-04-10

    Graphene, a single layer of carbon atoms arranged in a honeycomb lattice, is attracting significant interest because of its potential applications in electronic and optoelectronic devices. Although graphene exhibits almost uniform absorption within a large wavelength range, its interaction with light is weak. In this paper, the enhancement of the optical absorption in graphene photonic crystal structures is studied: the structure is modified by introducing scatterers and mirrors. It is shown that the absorption of the graphene photonic crystal structure can be enhanced about four times (nearly 40%) with respect to initial reference absorption of 9.8%. The study can be a useful tool for investigating graphene physics in different optical settings.

  4. Lessons learned from nutrition curricular enhancements.

    Science.gov (United States)

    Hark, Lisa A

    2006-04-01

    The Nutrition Academic Award funded 21 US medical schools to develop, implement, evaluate, and disseminate nutrition curricula for medical students, residents, and physicians in practice over a 5-y period. This article summarizes some of the important lessons learned from this process and offers guidance and strategies for long-term success of nutrition curricular enhancements. Medical educators need to continue to develop, implement, evaluate, and disseminate nutrition curricula with and without funding. By using the lessons learned and the products developed by the Nutrition Academic Award schools, educators will be in a position to enhance their medical curriculum.

  5. LARC database for Ground-Level Enhancements

    Science.gov (United States)

    Storini, Marisa

    Ground-Level Enhancements (GLEs) are enhancements observed in the counting rate of groundbased detectors related to the terrestrial incoming of solar relativistic particles, emitted during energetic activity phenomena on the Sun. LARC (acronym for Laboratorio Antartico per i Raggi Cosmici or Laboratorio Antartico para Rayos Cosmicos) neutron monitor is operating on King George Island since January 1991. The effective vertical rigidity cutoff for LARC location is about 3 GV, but it varies with time (actually, it decreases because of the secular variation of the geomagnetic field). We describe the solar particle event imprints on LARC records obtained from 1991 to 2007 by the Chile/Italy international collaboration.

  6. Klebsiella pneumoniae inoculants for enhancing plant growth

    Science.gov (United States)

    Triplett, Eric W [Middleton, WI; Kaeppler, Shawn M [Oregon, WI; Chelius, Marisa K [Greeley, CO

    2008-07-01

    A biological inoculant for enhancing the growth of plants is disclosed. The inoculant includes the bacterial strains Herbaspirillum seropedicae 2A, Pantoea agglomerans P101, Pantoea agglomerans P102, Klebsiella pneumoniae 342, Klebsiella pneumoniae zmvsy, Herbaspirillum seropedicae Z152, Gluconacetobacter diazotrophicus PA15, with or without a carrier. The inoculant also includes strains of the bacterium Pantoea agglomerans and K. pneumoniae which are able to enhance the growth of cereal grasses. Also disclosed are the novel bacterial strains Herbaspirillum seropedicae 2A, Pantoea agglomerans P101 and P102, and Klebsiella pneumoniae 342 and zmvsy.

  7. Enhancer RNAs: the new molecules of transcription.

    Science.gov (United States)

    Lai, Fan; Shiekhattar, Ramin

    2014-04-01

    In the past few years, technological advances in nucleotide sequencing have culminated in a greater understanding of the complexity of the human transcriptome. Notably, the discovery that distal regulatory elements known as enhancers are transcribed and such enhancer-derived transcripts (eRNAs) serve a critical function in transcriptional activation has added a new dimension to transcriptional regulation. Here we review recent insights into the tissue-specific and temporal-specific gene regulation brought about by the discovery of eRNAs. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Policy implications of technologies for cognitive enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Sarewitz, Daniel R. (Arizona State University, Tempe, AZ); Karas, Thomas H.

    2007-02-01

    The Advanced Concepts Group at Sandia National Laboratory and the Consortium for Science, Policy and Outcomes at Arizona State University convened a workshop in May 2006 to explore the potential policy implications of technologies that might enhance human cognitive abilities. The group's deliberations sought to identify core values and concerns raised by the prospect of cognitive enhancement. The workshop focused on the policy implications of various prospective cognitive enhancements and on the technologies/nanotechnology, biotechnology, information technology, and cognitive science--that enable them. The prospect of rapidly emerging technological capabilities to enhance human cognition makes urgent a daunting array of questions, tensions, ambitions, and concerns. The workshop elicited dilemmas and concerns in ten overlapping areas: science and democracy; equity and justice; freedom and control; intergenerational issues; ethics and competition; individual and community rights; speed and deliberations; ethical uncertainty; humanness; and sociocultural risk. We identified four different perspectives to encompass the diverse issues related to emergence of cognitive enhancement technologies: (1) Laissez-faire--emphasizes freedom of individuals to seek and employ enhancement technologies based on their own judgment; (2) Managed technological optimism--believes that while these technologies promise great benefits, such benefits cannot emerge without an active government role; (3) Managed technological skepticism--views that the quality of life arises more out of society's institutions than its technologies; and (4) Human Essentialism--starts with the notion of a human essence (whether God-given or evolutionary in origin) that should not be modified. While the perspectives differ significantly about both human nature and the role of government, each encompasses a belief in the value of transparency and reliable information that can allow public discussion and

  9. Is the enhancement of global warming important?

    International Nuclear Information System (INIS)

    Symons, M.C.R.; Barrett, J.

    2001-01-01

    There is no doubt that global warming is important; without it the Earth's surface would have a mean temperature of 33 o C lower than it has currently. The IPCC maintains that human activities are to blame for the observed increase in the concentration of carbon dioxide in the atmosphere since pre-industrial times. There are some doubts about whether global warming is being enhanced by the activities of the human race. This article reviews these doubts and the proposed remedies to the alleged enhancement. (author)

  10. Contrast enhancing techniques in digital holographic microscopy

    International Nuclear Information System (INIS)

    Lobera, J; Coupland, J M

    2008-01-01

    A digital holographic microscope (DHM) can be considered as a microscope with an extended depth of field. From a single DHM recording the propagating component of the scattered field can be reconstructed in three dimensions (3D). As in conventional white light microscopy contrasting enhancing techniques can be applied to highlight characteristics of interest. If these techniques are used to enhance the reconstruction from a DHM, then it is important to understand the characteristics of these techniques in 3D. In this paper the performance of phase contrast, differential interference contrast, Hoffman and spiral phase contrast visualization methods are discussed in 3D

  11. Overhauser-enhanced MR imaging (OMRI)

    DEFF Research Database (Denmark)

    Golman, K; Leunbach, I; Ardenkjaer-Larsen, JH

    1998-01-01

    Purpose. To evaluate a new single-electron contrast agent for Overhauser-enhanced MR imaging. The contrast agents that are currently available give enhancement factors that are too low to make the technique a valid option for routine clinical use. Material and Methods. MR images were generated...... directly following the injection of the substance into rats. The MR scanner was operated at a main magnetic field of 0.01 T and equipped with a separate rf-transmitter tuned to the electron paramagnetic resonance frequency of the contrast agent. Results. As expected, the images generated show a high level...

  12. Natural Image Enhancement Using a Biogeography Based Optimization Enhanced with Blended Migration Operator

    Directory of Open Access Journals (Sweden)

    J. Jasper

    2014-01-01

    Full Text Available This paper addresses a novel and efficient algorithm for solving optimization problem in image processing applications. Image enhancement (IE is one of the complex optimization problems in image processing. The main goal of this paper is to enhance color images such that the eminence of the image is more suitable than the original image from the perceptual viewpoint of human. Traditional methods require prior knowledge of the image to be enhanced, whereas the aim of the proposed biogeography based optimization (BBO enhanced with blended migration operator (BMO algorithm is to maximize the objective function in order to enhance the image contrast by maximizing the parameters like edge intensity, edge information, and entropy. Experimental results are compared with the current state-of-the-art approaches and indicate the superiority of the proposed technique in terms of subjective and objective evaluation.

  13. Inhibiting PHD2 in bone marrow mesenchymal stem cells via lentiviral vector-mediated RNA interference facilitates the repair of periodontal tissue defects in SD rats

    Science.gov (United States)

    Chen, Changxing; Li, Houxuan; Jiang, Jun; Zhang, Qian; Yan, Fuhua

    2017-01-01

    Hypoxia-inducible factors (HIFs) play an important role in angiogenesis, and they can activate the expression of several downstream angiogenic factors. HIF-1 is a major transcriptor of HIFs, composed of α and β subunits. Prolyl hydroxylase domain-containing protein 2 (PHD2) is the main catabolic enzyme for HIF-1α, and it can accelerate its degradation under normoxic conditions. PHD2 expression in bone marrow mesenchymal stem cells (BMMSCs) of SD rats was down-regulated under normoxic conditions in this study by utilizing lentiviral vector-mediated RNA interference to promote HIF-1α accumulation, thus enhancing the expression of angiogenic factors. A tissue-engineered compound was constructed using the composite collagen membrane of BMMSCs after PHD2 gene silencing to repair periodontal fenestration defects in SD rats. The results of this study indicated that, after PHD2 gene silencing, the osteogenic differentiation of BMMSCs was enhanced in vitro, the resistance of cells to oxidative stress was also validated in vitro, thereby illustrating the promotion of the repair of artificially constructed periodontal tissue defects in rats. The results of this study provide a reference and guidance for future applications of RNA interference in periodontal tissue engineering and serve as a basis for improving the survival of seed cells in recipient tissues. PMID:29069818

  14. Plasmonic Enhancement Mechanisms in Solar Energy Harvesting

    Science.gov (United States)

    Cushing, Scott K.

    Semiconductor photovoltaics (solar-to-electrical) and photocatalysis (solar-to-chemical) requires sunlight to be converted into excited charge carriers with sufficient lifetimes and mobility to drive a current or photoreaction. Thin semiconductor films are necessary to reduce the charge recombination and mobility losses, but thin films also limit light absorption, reducing the solar energy conversion efficiency. Further, in photocatalysis, the band edges of semiconductor must straddle the redox potentials of a photochemical reaction, reducing light absorption to half the solar spectrum in water splitting. Plasmonics transforms metal nanoparticles into antennas with resonances tuneable across the solar spectrum. If energy can be transferred from the plasmon to the semiconductor, light absorption in the semiconductor can be increased in thin films and occur at energies smaller than the band gap. This thesis investigates why, despite this potential, plasmonic solar energy harvesting techniques rarely appear in top performing solar architectures. To accomplish this goal, the possible plasmonic enhancement mechanisms for solar energy conversion were identified, isolated, and optimized by combining systematic sample design with transient absorption spectroscopy, photoelectrochemical and photocatalytic testing, and theoretical development. Specifically, metal semiconductor nanostructures were designed to modulate the plasmon's scattering, hot carrier, and near field interactions as well as remove heating and self-catalysis effects. Transient absorption spectroscopy then revealed how the structure design affected energy and charge carrier transfer between metal and semiconductor. Correlating this data with wavelength-dependent photoconversion efficiencies and theoretical developments regarding metal-semiconductor interactions identified the origin of the plasmonic enhancement. Using this methodology, it has first been proven that three plasmonic enhancement routes are

  15. The effect of substrate on electric field enhancement of Tip-enhanced Raman spectroscopy (TERS)

    Science.gov (United States)

    Bahreini, Maryam

    2018-01-01

    The characterization of materials down to a few-molecule level is a key challenge in nanotechnology. Raman spectroscopy is a powerful method that provides chemical information via nondestructive vibrational fingerprinting. Unfortunately, this method suffers from signal weakness which prevents the study of small quantities. Tip-enhanced Raman spectroscopy (TERS) which combines the chemical sensitivity of Raman spectroscopy (RS) with high spatial resolution of scanning probe microscopy (SPM), provides chemical images of surfaces at the nanometer scale. In this method, irradiation of an SPM tip by a focused laser beam results in enhancement of local electric field via two reasons of localized surface plasmon resonance and lightning rod effect. This enhancement leads to the enhancement in Raman intensity from the sample surface in the vicinity of tip. In all TERS measurements, samples should be located on a substrate. In this paper, the dependence of the electric field enhancement to the substrate has been investigated. In simulations, three-dimensional finite-difference time-domain (3D-FDTD) method is used for numerical solution of Maxwell's equations. Our results show that the electric field enhancement is weak for the tip alone case. Introducing a substrate provides further electric field enhancement via near field electromagnetic dipole-dipole coupling between the tip and substrate. Since the side-illumination geometry is used for laser irradiation, the vertical component of the incident field plays a dominant role in the electric field enhancement. Therefore, the coupling effect between the tip and the substrate is the key contribution to the enhancement. For the case of silicon tip and the gold substrate, the electric field enhancement is improved considerably. There is an optimal tip size for TERS because of the competing effects of the radiation damping and the surface scattering of the tip. The results show the substrate as an effective tool for the

  16. Contrast enhanced MR imaging of postoperative medulloblastoma in childhood: emphasis on meningeal enhancement

    International Nuclear Information System (INIS)

    Choi, Choong Gon; Kim, In One; Kim, Woo Sun; Kim, Ho Chul; Yeon, Kyung Mo

    1993-01-01

    To differentiate the postoperative changes from the recurrence of tumor and to evaluate MR imaging of early postoperative leptomeningeal seeding in medulloblastoma, We have retrospectively analysed 34 cases of MR images of 17 patients who were confirmed as medulloblastoma by histopathology. Noncontrast and postcontrast T1 weighted MR images were obtained in all patients. In 11 patients follow-up MR was done more than once (average: 1.5 times) and average interval of MR imaging was 6 months. The timing of 34 MR images was as follow: 6 case within 2 months, 9 cases between 2 months and 1 year, 19 cases more than 1 year after surgery respectively. MR images within 2 month after surgery revealed contrast enhancement at operation site and adjacent meninges, hemorrhage, residual tumor. In patients who had no evidence of tumor recurrence, these early postoperative changes were markedly decreased within 6 month after surgery. MR images obtained more than 1 year after surgery showed no abnormal contrast enhancement or mild focal dural enhancement at operation site. Diffuse moderate dural enhancement was noted in one patient who had the history of post-surgical subdural hemorrhage. In six patients with tumor recurrences which were detected from as early as 9 months to 6 years after surgery, the findings of recurrence included leptomeningeal enhancement of brain stem and cerebellar surface at early stage, variable sized enhancing leptomeningeal nodules, linear or irregular sulcus obliterating enhancing lesions, enhancing mass at primary or metastatic site. We have concluded that leptomeningeal enhancement detected after 6 months of surgery is an important MR finding suggesting the possibility of tumor recurrence. Small nodular and linear enhancement of leptomeninges at brainstem or cerebellar surface is considered as the early manifestation of intracranial tumor seeding

  17. Induced resistance: an enhancement of basal resistance?

    NARCIS (Netherlands)

    Vos, M. de; Robben, C.; Pelt, J.A. van; Loon, L.C. van; Pieterse, C.M.J.

    2002-01-01

    Upon primary pathogen attack, plants activate resistance mechanisms at the site of infection. Besides this so-called basal resistance, plants have also the ability to enhance their defensive capacity against future pathogen attack. There are at least two types of biologically induced resistance.

  18. Enhancing Advocacy Skills of Teacher Candidates

    Science.gov (United States)

    Holmes, Melissa A.; Herrera, Socorro G.

    2009-01-01

    This case study explores the dynamics of enhancing the capacities of teacher candidates in the Bilingual/Bicultural Education Students Interacting to Obtain Success (BESITOS) recruitment and retention program to advocate for culturally and linguistically diverse (CLD) students. Herrera and Murry's advocacy framework provides the theoretical…

  19. Enhancement of reaction rates for catalytic benzaldehyde ...

    Indian Academy of Sciences (India)

    High-pressure carbon dioxide; high-temperature liquid water; carbonic acid. 1. Introduction. We have succeeded to ... Also, cost-consuming troublesome proce- dures are needed for neutralization of acid, and salts .... high hydrogen solubility to organic phase may cause the enhancement of the hydrogenation yield by ...

  20. Enhancing Education through Mobile Augmented Reality

    Science.gov (United States)

    Joan, D. R. Robert

    2015-01-01

    In this article, the author has discussed about the Mobile Augmented Reality and enhancing education through it. The aim of the present study was to give some general information about mobile augmented reality which helps to boost education. Purpose of the current study reveals the mobile networks which are used in the institution campus as well…

  1. Enhanced Controlled Transdermal Delivery of Torasemide Using ...

    African Journals Online (AJOL)

    To increase pore size and flexibility of the EVA matrix, plasticizers with citrate and phthalate groups were added to the matrix containing torasemide. To improve the ... The effects of the enhancers on the skin penetration were evaluated using Franz diffusion cell fitted with the intact excised rat skin. Results: Solubility and ...

  2. Enhanced integrated nonthermal treatment system study

    Energy Technology Data Exchange (ETDEWEB)

    Biagi, C.; Schwinkendorf, B.; Teheranian, B.

    1997-02-01

    The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer.

  3. Biosurfactant-enhanced remediation of hydrocarbon contaminated ...

    African Journals Online (AJOL)

    Crude biosurfactant extract produced by two microbial isolates, Pseudomonas mallei and Pseudomonas pseudomallei were used to enhance the biodegradation rates of petroleum hydrocarbon pollutants in a mangrove swamp in Nigeria. Nutrient application in combination with biosurfactants showed very significant ...

  4. Assessing Participation in Secondary Education Quality Enhancement

    African Journals Online (AJOL)

    Assessing Participation in Secondary Education Quality Enhancement: Teachers, Parents and Communities in Cross River State. ... ailing economy, low moral values and philosophy of the end justifies the means were reasons for low parents and communities involvement in secondary education-quality improvement.

  5. Prevalent vegetation growth enhancement in urban environment.

    Science.gov (United States)

    Zhao, Shuqing; Liu, Shuguang; Zhou, Decheng

    2016-05-31

    Urbanization, a dominant global demographic trend, leads to various changes in environments (e.g., atmospheric CO2 increase, urban heat island). Cities experience global change decades ahead of other systems so that they are natural laboratories for studying responses of other nonurban biological ecosystems to future global change. However, the impacts of urbanization on vegetation growth are not well understood. Here, we developed a general conceptual framework for quantifying the impacts of urbanization on vegetation growth and applied it in 32 Chinese cities. Results indicated that vegetation growth, as surrogated by satellite-observed vegetation index, decreased along urban intensity across all cities. At the same time, vegetation growth was enhanced at 85% of the places along the intensity gradient, and the relative enhancement increased with urban intensity. This growth enhancement offset about 40% of direct loss of vegetation productivity caused by replacing productive vegetated surfaces with nonproductive impervious surfaces. In light of current and previous field studies, we conclude that vegetation growth enhancement is prevalent in urban settings. Urban environments do provide ideal natural laboratories to observe biological responses to environmental changes that are difficult to mimic in manipulative experiments. However, one should be careful in extrapolating the finding to nonurban environments because urban vegetation is usually intensively managed, and attribution of the responses to diverse driving forces will be challenging but must be pursued.

  6. Memory enhancing activity of Spondias mombin Anarcadiaceae ...

    African Journals Online (AJOL)

    Memory enhancing activities of both extracts were evaluated in scopolamine induced amnesic mice in Morris water maze test at various doses by determining the escape latency. The histopathology of the brain was also carried out to assess any change to the hippocampus that might have effects on memory. Results:The ...

  7. Salmon River Habitat Enhancement, 1989 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, Mike

    1989-04-01

    This project was funded by the Bonneville Power Administration (BPA). The annual report contains three individual subproject papers detailing tribal fisheries work completed during the summer and fall of 1989. Subproject 1 contains summaries of evaluation/monitoring efforts associated with the Bear Valley Creek, Idaho enhancement project. Subproject 2 contains an evaluation of the Yankee Fork of the Salmon River habitat enhancement project. This report has been sub-divided into two parts: Part 1; stream evaluation and Part 2; pond series evaluation. Subproject 3 concerns the East Fork of the Salmon River, Idaho. This report summarizes the evaluation of the project to date including the 1989 pre-construction evaluation conducted within the East Fork drainage. Dredge mining has degraded spawning and rearing habitat for chinook salmon and steelhead trout in the Yankee Fork drainage of the Salmon River and in Bear Valley Creek. Mining, agricultural, and grazing practices degraded habitat in the East Fork of the Salmon River. Biological monitoring of the success of habitat enhancement for Bear Valley Creek and Yankee Fork are presented in this report. Physical and biological inventories prior to habitat enhancement in East Fork were also conducted. Four series of off-channel ponds of the Yankee Fork are shown to provide effective rearing habitat for chinook salmon. 45 refs., 49 figs., 24 tabs.

  8. Enhancing Supervisor and Subordinate Communication in Diversity ...

    African Journals Online (AJOL)

    provides for the institutionalisation of diversity management by integrating it with the organisation's management practices. This article proposes that communication between supervisors and subordinates in the public service must be strengthened to enhance diversity management. It argues that diversity management is an ...

  9. Enhancing composite durability : using thermal treatments

    Science.gov (United States)

    Jerrold E. Winandy; W. Ramsay Smith

    2007-01-01

    The use of thermal treatments to enhance the moisture resistance and aboveground durability of solid wood materials has been studied for years. Much work was done at the Forest Products Laboratory in the last 15 years on the fundamental process of both short-and long-term exposure to heat on wood materials and its interaction with various treatment chemicals. This work...

  10. Do pedagogical agents enhance software training?

    NARCIS (Netherlands)

    van der Meij, Hans

    2013-01-01

    This study investigates whether a tutorial for software training can be enhanced by adding a pedagogical agent, and whether the type of agent matters (i.e., cognitive, motivational, or mixed). The cognitive agent was designed to stimulate students to process their experiences actively. The

  11. Contextualising the National Development Plan for enhanced ...

    African Journals Online (AJOL)

    Strategy, Integrated Development Planning, enhanced service delivery ..... Regarding transport and logistics infrastructure, the key focus .... In essence, spatial equity aims to locate services at accessible and convenient places for residents and support through well-developed transport systems. Therefore, the. NDP refers to ...

  12. A Sexual Enhancement Program for Elderly Couples

    Science.gov (United States)

    Rowland, Kay F.; Haynes, Stephen N.

    1978-01-01

    This study examined effects of a group sexual enhancement program for elderly couples. The three two-week phases, pretreatment with no therapist contact, education on human sexual functioning in aging people, and communication exercises-sexual techniques, were methods to improve communication and increase enjoyment of sexual contact. (Author)

  13. Enhancing the Psychology STEM Student Journey

    Science.gov (United States)

    Hill, Kimberley M.

    2017-01-01

    Psychology is a valuable Science, Technology, Engineering, and Mathematics (STEM) discipline, but one which could do far more at communicating its value to the wider public. This paper discusses how popular initiatives, such as "The University of Northampton's STEM Champions" programme, enhance psychology's STEM membership, while…

  14. Enhanced lipase production by mutation induced Aspergillus ...

    African Journals Online (AJOL)

    ... the HNO2 mutant (AHN3) and 217% higher than the UV mutant (AUV3) and 276% higher lipase activity than the parent strain. The results indicated that UV, HNO2 and NTG treatment were effective physical and chemical mutagenic agents for strain improvement of Aspergillus japonicus for enhanced lipase productivity.

  15. Enhancing Life Purpose amongst Thai Adolescents

    Science.gov (United States)

    Balthip, Karnsunaphat; McSherry, Wilfred; Petchruschatachart, Usanee; Piriyakoontorn, Siriwan; Liamputtong, Pranee

    2017-01-01

    This article describes experiences that enhanced life purpose in 21 Thai adolescents living in Southern Thailand. Thailand is undergoing rapid change from technology, a globalizing economy, and shifting social norms. A phenomenological analysis of in-depth interviews and stories to better understand how Thai youth themselves experience and…

  16. ENHANCEMENTS TO NATURAL ATTENUATION: SELECTED CASE STUDIES

    Energy Technology Data Exchange (ETDEWEB)

    Vangelas, K; W. H. Albright, W; E. S. Becvar, E; C. H. Benson, C; T. O. Early, T; E. Hood, E; P. M. Jardine, P; M. Lorah, M; E. Majche, E; D. Major, D; W. J. Waugh, W; G. Wein, G; O. R. West, O

    2007-05-15

    In 2003 the US Department of Energy (DOE) embarked on a project to explore an innovative approach to remediation of subsurface contaminant plumes that focused on introducing mechanisms for augmenting natural attenuation to achieve site closure. Termed enhanced attenuation (EA), this approach has drawn its inspiration from the concept of monitored natural attenuation (MNA).

  17. Efficient microwave irradiation enhanced stereoselective synthesis ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 122; Issue 4. Efficient microwave irradiation enhanced stereoselective synthesis and antitumor activity of indolylchalcones and their pyrazoline analogs. Magdy A H Zahran Hanan F Salama Yasmin G Abdin Amira M Gamal-Eldeen. Full Papers Volume 122 Issue 4 ...

  18. An investigation into the mechanism underlying enhanced ...

    African Journals Online (AJOL)

    The solubilisation of primary sewage sludge under sulphate reducing conditions was conducted in controlled flask studies and previously reported findings of enhanced hydrolysis were confirmed. The maximum percentage solubilisation obtained in this study over a 10-day period was 31% and 64% for the methanogenic ...

  19. Contextualising the National Development Plan for enhanced ...

    African Journals Online (AJOL)

    Integrated Development Plans (IDPs) are the planning instruments directed at strategies for enhancing service delivery in local government. As a consequence, capacity initiatives are driven by these plans to address prioritised developmental needs. The key to establishing such initiatives is informed by the National ...

  20. UF6 cylinder lifting equipment enhancements

    International Nuclear Information System (INIS)

    Hortel, J.M.

    1991-01-01

    This paper presents numerous enhancements that have been made to the Portsmouth lifting equipment to ensure the safe handling of cylinders containing liquid uranium hexafluoride (UF 6 ). The basic approach has been to provide redundancy to all components of the lift path so that any one component failure would not cause the load to drop or cause any undesirable movement. 4 figs

  1. Enhanced production of intracellular dextran dextrinase from ...

    African Journals Online (AJOL)

    Enhanced production of intracellular dextran dextrinase from Gluconobacter oxydans using statistical experimental methods. ... the Plackett-Burman screening. A four-factor five-level central composite design (CCD) was chosen to explain the combined effects of the four medium constituents. The optimum medium consisted ...

  2. Methylphenidate Enhances Extinction of Contextual Fear

    Science.gov (United States)

    Abraham, Antony D.; Cunningham, Christopher L.; Lattal, K. Matthew

    2012-01-01

    Methylphenidate (MPH, Ritalin) is a norepinephrine and dopamine transporter blocker that is widely used in humans for treatment of attention deficit disorder and narcolepsy. Although there is some evidence that targeted microinjections of MPH may enhance fear acquisition, little is known about the effect of MPH on fear extinction. Here, we show…

  3. Instructor Touch Enhanced College Students' Evaluations

    Science.gov (United States)

    Legg, Angela M.; Wilson, Janie H.

    2013-01-01

    Touch between people is associated with several outcomes, including reduced stress, more positive mood, enhanced feelings of closeness, and positive behavioral change. However, the potential utility of touch rarely has been examined in a college sample, with teachers touching their students. In the present study, we used instrumental touch…

  4. Enhancing Critical Thinking: Accounting Students' Perceptions

    Science.gov (United States)

    Wilkin, Carla L.

    2017-01-01

    Purpose: The purpose of this paper is to demonstrate how assessment design was used to enhance students' critical thinking in a subject concerned with business enterprise systems. The study shows positive results and favorable perceptions of the merit of the approach. Design/Methodology/Approach: A case study approach was used to examine how the…

  5. Enhanced integrated nonthermal treatment system study

    International Nuclear Information System (INIS)

    Biagi, C.; Schwinkendorf, B.; Teheranian, B.

    1997-02-01

    The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer

  6. Nonlinear adaptive models for speech enhancement algorithms

    Czech Academy of Sciences Publication Activity Database

    Koula, Ivan; Zezula, R.

    2007-01-01

    Roč. 42, č. 1 (2007), s. 138-145 ISSN 1738-6438 R&D Projects: GA ČR(CZ) GA102/06/1233; GA AV ČR(CZ) 1ET301710509 Institutional research plan: CEZ:AV0Z20670512 Keywords : noise measurement * speech enhancement * neural nets Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  7. REVIEW OF PCMs AND HEAT TRANSFER ENHANCEMENT ...

    African Journals Online (AJOL)

    HOD

    Solar thermal power generation requires a cost effective thermal storage system. The existing two tank ... PCMS AND HEAT TRANSFER ENHANCEMENT METHODS IN PARABOLIC TROUGH SOLAR PLANTS THERMAL STORAGE SYSTEMS, M. D. Muhammad. Nigerian Journal of ..... However, there is still the need for.

  8. Enhancement effect of irradiation by methotrexate

    International Nuclear Information System (INIS)

    Shehata, W.M.; Meyer, R.L.

    1980-01-01

    Three cases are described in which complications developed which were believed to be due to the enhancement effect of irradiation by methotrexate during the course of therapy for lung, kidney, and bladder cancer. These included esophageal and large bowel complications. In two of these cases, the patients improved with conservative therapy

  9. Enhanced Context Recognition by Sensitivity Pruned Vocabularies

    DEFF Research Database (Denmark)

    Madsen, Rasmus Elsborg; Sigurdsson, Sigurdur; Hansen, Lars Kai

    2004-01-01

    a latent semantic indexing representation and a probabilistic neural network classifier. Pruning the vocabularies to approximately 20% of the original size, we find consistent context recognition enhancement for two mid size data-sets for a range of training set sizes. We also study the applicability...

  10. Sleep Enhances Explicit Recollection in Recognition Memory

    Science.gov (United States)

    Drosopoulos, Spyridon; Wagner, Ullrich; Born, Jan

    2005-01-01

    Recognition memory is considered to be supported by two different memory processes, i.e., the explicit recollection of information about a previous event and an implicit process of recognition based on a contextual sense of familiarity. Both types of memory supposedly rely on distinct memory systems. Sleep is known to enhance the consolidation of…

  11. Carbon nanostructured surfaces for enhanced heat transport

    NARCIS (Netherlands)

    Taha, T.J.

    2015-01-01

    The advancement of high performance thermal systems has stimulated interest in methods to improve heat transfer rates. Considerable efforts have been made to increase heat transfer rates by implementing passive convective heat transfer enhancement methods that require no direct consumption of

  12. Enhancing community health workers support for maternal ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project, a collaboration between the Bruyère Research Institute and Shirati KMT Council Designated Hospital, will complement a current project to build an enhanced cadre of community health workers in rural Tanzania by integrating a focus on the reproductive health needs of women. The project will train community ...

  13. Microwave Enhancement in Coronal Holes: Statistical Properties

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Astrophysics and Astronomy; Volume 21; Issue 3-4. Microwave Enhancement in Coronal Holes: Statistical Properties. Ν. Gopalswamy Κ. Shibasaki Μ. Salem. Session X – Cycle Variation in the Quiet Corona & Coronal Holes Volume 21 Issue 3-4 September-December 2000 pp 413-417 ...

  14. Evaluating human enhancements: the importance of ideals.

    Science.gov (United States)

    Roduit, Johann A R; Baumann, Holger; Heilinger, Jan-Christoph

    2014-01-01

    Is it necessary to have an ideal of perfection in mind to identify and evaluate true biotechnological human "enhancements", or can one do without? To answer this question we suggest employing the distinction between ideal and non-ideal theory, found in the debate in political philosophy about theories of justice: the distinctive views about whether one needs an idea of a perfectly just society or not when it comes to assessing the current situation and recommending steps to increase justice. In this paper we argue that evaluating human enhancements from a non-ideal perspective has some serious shortcomings, which can be avoided when endorsing an ideal approach. Our argument starts from a definition of human enhancement as improvement, which can be understood in two ways. The first approach is backward-looking and assesses improvements with regard to a status quo ante. The second, a forward-looking approach, evaluates improvements with regard to their proximity to a goal or according to an ideal. After outlining the limitations of an exclusively backward-looking view (non-ideal theory), we answer possible objections against a forward-looking view (ideal theory). Ultimately, we argue that the human enhancement debate would lack some important moral insights if a forward-looking view of improvement is not taken into consideration.

  15. Enhancing Critical Thinking Skills among Authoritarian Students

    Science.gov (United States)

    Henderson Hurley, Martha; Hurley, David

    2013-01-01

    This article focuses on assignments designed to enhance critical thinking skills for authoritarian personality types. This paper seeks to add to the literature by exploring instructional methods to overcome authoritarian traits that could inhibit the development of critical thinking skills. The article presents a strategy which can be employed…

  16. Prevalent vegetation growth enhancement in urban environment

    Science.gov (United States)

    Zhao, Shuqing; Liu, Shuguang; Zhou, Decheng

    2016-01-01

    Urbanization, a dominant global demographic trend, leads to various changes in environments (e.g., atmospheric CO2 increase, urban heat island). Cities experience global change decades ahead of other systems so that they are natural laboratories for studying responses of other nonurban biological ecosystems to future global change. However, the impacts of urbanization on vegetation growth are not well understood. Here, we developed a general conceptual framework for quantifying the impacts of urbanization on vegetation growth and applied it in 32 Chinese cities. Results indicated that vegetation growth, as surrogated by satellite-observed vegetation index, decreased along urban intensity across all cities. At the same time, vegetation growth was enhanced at 85% of the places along the intensity gradient, and the relative enhancement increased with urban intensity. This growth enhancement offset about 40% of direct loss of vegetation productivity caused by replacing productive vegetated surfaces with nonproductive impervious surfaces. In light of current and previous field studies, we conclude that vegetation growth enhancement is prevalent in urban settings. Urban environments do provide ideal natural laboratories to observe biological responses to environmental changes that are difficult to mimic in manipulative experiments. However, one should be careful in extrapolating the finding to nonurban environments because urban vegetation is usually intensively managed, and attribution of the responses to diverse driving forces will be challenging but must be pursued. PMID:27185955

  17. Enhancement of proton conductivity of sulfonated polystyrene ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 37; Issue 7. Enhancement of proton conductivity of sulfonated polystyrene membrane prepared by plasma polymerization process. Bhabesh Kumar Nath Aziz Khan Joyanti Chutia Arup Ratan Pal Heremba Bailung Neelotpal Sen Sarma Devasish Chowdhury Nirab ...

  18. Enhanced transport of relativistic electrons through nanochannels

    Directory of Open Access Journals (Sweden)

    Prashant Kumar Singh

    2013-06-01

    Full Text Available Efficient transport of fast electrons driven by intense laser solid interaction depends crucially on optimal target design. We demonstrate a hybrid target design that incorporates two important features—efficient generation of relativistic electrons and their unimpeded transport in dense media. The target was fabricated on a porous alumina base consisting of an array of sublambda cylindrical holes partially filled with Cu nanorods, such that light field propagates in the hollow channels, located ahead of the metallic fillings. The hollow array acts as an efficient source of hot electrons when driven by relativistically intense, femtosecond laser pulses and shows a 60-fold enhancement in electron flux compared to a solid target. This enhancement is ascribed to an increased penetration of laser through subwavelength pores and enhanced local electric fields. The metal doped part facilitates efficient transport of the generated electrons, due to its large background conductivity. A 4-fold enhancement in target rear side electron flux is observed compared with unfilled porous alumina.

  19. Total Recall: Using Film to Enhance Learning

    Science.gov (United States)

    Clayton, Douglas N.

    2012-01-01

    Several scholars (e.g. Bumpus, 2005; Champoux, 1999; Mayer, 2005) and practitioners (Gallos 2007; English & Steffy, 1995; Hackley, 2007) of workplace learning have put forward the claim that the use of film (and other forms of multimedia) enhances learning. If this is the case, particularly given the increasing pressure to do more with less,…

  20. Enhancing Students' Language Skills through Blended Learning

    Science.gov (United States)

    Banditvilai, Choosri

    2016-01-01

    This paper presents a case study of using blended learning to enhance students' language skills and learner autonomy in an Asian university environment. Blended learning represents an educational environment for much of the world where computers and the Internet are readily available. It combines self-study with valuable face-to-face interaction…

  1. Clouds enhance Greenland ice sheet meltwater runoff

    NARCIS (Netherlands)

    Van Tricht, K.; Lhermitte, S.; Lenaerts, J. T M; Gorodetskaya, I. V.; L'Ecuyer, T. S.; Noël, B.; Van Den Broeke, M. R.; Turner, D. D.; Van Lipzig, N. P M

    2016-01-01

    The Greenland ice sheet has become one of the main contributors to global sea level rise, predominantly through increased meltwater runoff. The main drivers of Greenland ice sheet runoff, however, remain poorly understood. Here we show that clouds enhance meltwater runoff by about one-third relative

  2. Radiation enhanced conduction in insulators: computer modelling

    International Nuclear Information System (INIS)

    Fisher, A.J.

    1986-10-01

    The report describes the implementation of the Klaffky-Rose-Goland-Dienes [Phys. Rev. B.21 3610,1980] model of radiation-enhanced conduction and describes the codes used. The approach is demonstrated for the data for alumina of Pells, Buckley, Hill and Murphy [AERE R.11715, 1985]. (author)

  3. Molecular biological enhancement of coal biodesulfurization

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, J.J. II; Bielaga, B.A.

    1991-12-01

    The overall objective of this project was to use molecular genetics to develop strains of bacteria with enhanced ability to remove sulfur from coal, and to obtain data that will allow the performance and economics of a coal biodesulfurization process to be predicted. (VC)

  4. Enhancing collaborative innovation in the public sector

    DEFF Research Database (Denmark)

    Sørensen, Eva; Torfing, Jacob

    2011-01-01

    demand for public innovation, and demonstrates how it can be enhanced through multiactor collaboration. The case for collaborative innovation is supported by insights from three different social science theories. The theoretical discussion leads to the formulation of an analytical model that can be used...

  5. Enhancement of reaction rates for catalytic benzaldehyde ...

    Indian Academy of Sciences (India)

    The effect of pressured carbon dioxide on heterogeneous hydrogenation of benzaldehyde and homogeneous dehydration of sorbitol in water solvent was studied. Initial hydrogenation rates of benzaldehyde over a charcoal-supported palladium catalyst in water at 313 K were enhanced by the addition of carbon dioxide.

  6. Enhanced Electrokinetic Remediation of Cadmium Contaminated Soil

    African Journals Online (AJOL)

    In an attempt to remediate contaminated soil, a new technique of purging cadmium from soil is examined by enhanced electrokinetic method. It involves the passage of low level direct current between two electrodes in the soil to remove contaminant. An apparatus consisting of four principal parts; soil cell, electrode ...

  7. Managing Risk, Reducing Vulnerability and Enhancing Productivity ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Managing Risk, Reducing Vulnerability and Enhancing Productivity under a Changing Climate. The countries of the Greater Horn of Africa are particularly vulnerable to drought, exacerbated by widespread poverty and dependence on rainfed agriculture. Even with normal rainfall, the region does not produce enough food to ...

  8. Giant light enhancement in atomic clusters

    International Nuclear Information System (INIS)

    Gadomsky, O. N.; Gadomskaya, I. V.; Altunin, K. K.

    2009-01-01

    We show that the polarizing effect of the atoms in an atomic cluster can lead to full compensation of the radiative damping of excited atomic states, a change in the sign of the dispersion of the atomic polarizability, and giant light enhancement by the atomic cluster.

  9. Assurance "versus" Enhancement: Less Is More?

    Science.gov (United States)

    Raban, Colin

    2007-01-01

    It is commonly assumed that there is a zero sum contest between assurance and enhancement: the drive to secure the accountability of institutions to their external stakeholders, and of teachers to their managers, is thought to undermine the creativity and commitment of "front line" academic staff. In exploring the roots of the problem,…

  10. Fatiguing exercise enhances hyperalgesia to muscle inflammation.

    Science.gov (United States)

    Sluka, Kathleen A; Rasmussen, Lynn A

    2010-02-01

    Since many people with chronic fatigue present with pain and many people with chronic pain present with fatigue, we tested if fatigue would enhance the response to pain in male and female mice. We further tested for the activation of brainstem nuclei by the fatigue task using c-fos as a marker. Fatigue was induced by having mice spontaneously run in running wheel for 2h. Carrageenan (0.03%) was injected into the gastrocnemius muscle either 2h before or 2h after the fatigue task. The mechanical sensitivity of the paw (von Frey filaments), muscle (tweezers), grip force and running wheel activity was assessed before and 24h after injection of carrageenan. Both male and female mice that performed the fatigue task, either before or after intramuscular injection of carrageenan, showed an enhanced mechanical sensitivity of the paw, but not the muscle. Ovariectomized mice showed a similar response to male mice. There was a decrease in running wheel activity after carrageenan injection, but no change in grip force suggesting that mice had no deficit in motor performance induced by the carrageenan. C-fos expression was observed in the nucleus raphe pallidus, obscurus, and magnus after the fatigue task suggesting an increased activity in the raphe nuclei in response to the fatigue task. Therefore, widespread hyperalgesia is enhanced by the fatigue response but not hyperalgesia at the site of insult. We suggest that this effect is sex-dependent and involves mechanisms in the brainstem to result in an enhanced hyperalgesia.

  11. Enhanced spectrofluorimetric determination of the multitargeted ...

    African Journals Online (AJOL)

    Purpose: To quantify the multi-targeted tyrosine kinase inhibitor, crizotinib, in human plasma and bulk powder by highly sensitive micellar enhanced spectrofluorimetric procedure. Method: The developed procedure was based on measuring the fluorescence intensity of crizotinib (CRZ) in sodium dodecyl sulphate (SDS) ...

  12. Critical enhancement of photorefractive beam coupling

    DEFF Research Database (Denmark)

    Podivilov, E.V.; Sturman, B.I.; Pedersen, H.C.

    2000-01-01

    We show that a hybridization of the optical and material nonlinearities takes place near the threshold of the subharmonic generation in photorefractive crystals. It results in a critical (with a singularity) enhancement of the rate of spatial amplification of light waves and leads to a variety...

  13. Optimization of epidemiological conditions to enhance the ...

    African Journals Online (AJOL)

    A new foliage disease was found on Chenopodium album L. (family chenopodiaceae) in Punjab, Pakistan. Alternaria alternata (Fr.) Keissler was identified and confirmed as the causal agent. The present study aimed to optimize environmental condition that could enhance mycoherbicidal potential of A. alternata against C.

  14. Potassium doped MWCNTs for hydrogen storage enhancement

    International Nuclear Information System (INIS)

    Adabi Qomi, S.; Gashtasebi, M.; Khoshnevisan, B.

    2012-01-01

    Here we have used potassium doped MWCNTs for enhancement of hydrogen storage process. XRD and SEM images have confirmed the doping of potassium. For studying the storage process a hydrogenic battery set up has been used. In the battery the working electrode has been made of the silver foam deposited by the doped MWCNTs electrophoretically.

  15. Oxide interfaces with enhanced ion conductivity

    NARCIS (Netherlands)

    Leon, C.; Santamaria, J.; Boukamp, Bernard A.

    2013-01-01

    The new field of nano-ionics is expected to yield large improvements in the performance of oxide-based energy generation and storage devices based on exploiting size effects in ion conducting materials. The search for novel materials with enhanced ionic conductivity for application in energy devices

  16. Enhancing Energy Efficient TCP by Partial Reliability

    NARCIS (Netherlands)

    Donckers, L.; Smit, Gerardus Johannes Maria; Havinga, Paul J.M.; Smit, L.T.

    We present a study on the effects on a mobile system's energy efficiency of enhancing, with partial reliability, our energy efficient TCP variant (E/sup 2/TCP) (see Donckers, L. et al., Proc. 2nd Asian Int. Mobile Computing Conf. - AMOC2002, p.18-28, 2002). Partial reliability is beneficial for

  17. Automated image enhancement using power law transformations

    Indian Academy of Sciences (India)

    We propose a scheme for automating power law transformations which are used for image enhancement. The scheme we propose does not require the user to choose the exponent in the power law transformation. This method works well for images having poor contrast, especially to those images in which the peaks ...

  18. Enhancing Life Sciences Teachers' Biodiversity Knowledge : A ...

    African Journals Online (AJOL)

    This paper provides insights into how Life Sciences teachers in the Eastern Cape can be supported through professional learning communities (PLCs) as a potential approach to enhancing their biodiversity knowledge. PLCs are communities that provide the setting and necessary support for groups of classroom teachers to ...

  19. Brain performance enhancement for military operators

    NARCIS (Netherlands)

    Erp, J.B.F.; Reschke, S.; Grootjen, M.; Brouwer, A.-M.

    2009-01-01

    Performance of military operators depends on both physical and cognitive aspects. Enhancement of operator performance should therefore address both the body and the brain. This paper focuses on the latter. We provide an extended list of areas where neuroscientific knowledge may be important like

  20. Sleep Does Not Enhance Motor Sequence Learning

    Science.gov (United States)

    Rickard, Timothy C.; Cai, Denise J.; Rieth, Cory A.; Jones, Jason; Ard, M. Colin

    2008-01-01

    Improvements in motor sequence performance have been observed after a delay involving sleep. This finding has been taken as evidence for an active sleep consolidation process that enhances subsequent performance. In a review of this literature, however, the authors observed 4 aspects of data analyses and experimental design that could lead to…

  1. Moral Enhancement and Those Left Behind

    NARCIS (Netherlands)

    Archer, Alfred

    2016-01-01

    Opponents to genetic or biomedical human enhancement often claim that the availability of these technologies would have negative consequences for those who either choose not to utilize these resources or lack access to them. However, Thomas Douglas has argued that this objection has no force against

  2. Patentability of methods of human enhancement

    DEFF Research Database (Denmark)

    Nordberg, Ana

    2015-01-01

    This article explores how to apply patentability rules to human enhancement, particularly focusing on Article 53(c) of the European Patent Convention (EPC). The global size and value of the cosmetic and wellness market and industry allow for the prediction of considerable market potential for human...

  3. Enhancing the Lecture: Revitalizing the Traditional Format.

    Science.gov (United States)

    Bonwell, Charles C.

    1996-01-01

    The traditional lecture format of college courses can be enhanced by including active learning designed to further course goals of learning knowledge, developing skills, or fostering attitudes. Techniques suggested include using pauses, short writing periods, think-pair-share activities, formative quizzes, lecture summaries, and several assessment…

  4. Immunoengineering: how nanotechnology can enhance cancer immunotherapy.

    Science.gov (United States)

    Goldberg, Michael S

    2015-04-09

    Although cancer immunotherapy can lead to durable outcomes, the percentage of patients who respond to this disruptive approach remains modest to date. Encouragingly, nanotechnology can enhance the efficacy of immunostimulatory small molecules and biologics by altering their co-localization, biodistribution, and release kinetics. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Digital Image Enhancement of Indic Historical Manuscripts

    Science.gov (United States)

    Shi, Zhixin; Setlur, Srirangaraj; Govindaraju, Venu

    Historical documents in Indic scripts can be found on a wide range of media such as paper, palm leaves, and parchment. Palm leaves are believed to be one of the earliest forms of writing media and their use as writing material has been recorded in various parts of the world including India. Ancient palm leaf manuscripts relating to religion, science, medicine, astronomy are still available for reference today due to many ongoing efforts for preservation of ancient documents by libraries and universities around the world. These manuscripts typically last a few centuries but with time the leaves degrade and the writing becomes illegible. Image processing techniques can help enhance the images of these manuscripts so as to enable readability of the written text. In this chapter, we propose methods for enhancing digital images of palm leaf and other historical manuscripts. We approximate the background of a gray-scale image using piece-wise linear and nonlinear models. Normalization algorithms are used on the color channels of the palm leaf image to obtain an enhanced gray-scale image. Experimental results show significant improvement in readability. An adaptive local connectivity map is used to try to segment lines of text from the enhanced images with the objective of facilitating techniques such as keyword spotting or partial OCR and thereby making it possible to index these documents for retrieval from a digital library.

  6. The current research status of enhancer RNAs.

    Science.gov (United States)

    Cheng, Xiao; Yang, Qiong; Tan, Zhen-Dong; Tan, Ya; Pu, Hongzhou; Zhao, Xue; Zhang, Shun-Hua; Zhu, Li

    2017-09-20

    Enhancers are key cis-acting gene regulatory elements in eukaryotes, which can effectively promote the expression of target genes. Emerging evidence showed that enhancers in activation state could be transcribed to enhancer RNAs (eRNAs), the processes of which are regulated by various signaling systems and actions of signal-dependent transcription factors. Compared with the other transcripts (e.g. lncRNA, mRNA), eRNAs have shorter sequences, lower stability, and higher tissue specificity. eRNAs play roles in the initiation or stabilization of enhancer-promoter looping, and promote the expression of target genes. Recent studies have further showed that eRNAs have crucial roles in biological processes, such as development and disease initiation and progression. However, functional studies of eRNAs are currently lacking, and the regulatory mechanisms of eRNAs are still uncertain. Herein, we focus on the features, research methods and functional properties of eRNAs, and discusse the possibility of using eRNAs as therapeutic targets. We hope this discussion might provide some insights for further research on eRNAs.

  7. Methadone enhances human influenza A virus replication.

    Science.gov (United States)

    Chen, Yun-Hsiang; Wu, Kuang-Lun; Tsai, Ming-Ta; Chien, Wei-Hsien; Chen, Mao-Liang; Wang, Yun

    2017-01-01

    Growing evidence has indicated that opioids enhance replication of human immunodeficiency virus and hepatitis C virus in target cells. However, it is unknown whether opioids can enhance replication of other clinically important viral pathogens. In this study, the interaction of opioid agonists and human influenza A/WSN/33 (H1N1) virus was examined in human lung epithelial A549 cells. Cells were exposed to morphine, methadone or buprenorphine followed by human H1N1 viral infection. Exposure to methadone differentially enhanced viral propagation, consistent with an increase in virus adsorption, susceptibility to virus infection and viral protein synthesis. In contrast, morphine or buprenorphine did not alter H1N1 replication. Because A549 cells do not express opioid receptors, methadone-enhanced H1N1 replication in human lung cells may not be mediated through these receptors. The interaction of methadone and H1N1 virus was also examined in adult mice. Treatment with methadone significantly increased H1N1 viral replication in lungs. Our data suggest that use of methadone facilitates influenza A viral infection in lungs and might raise concerns regarding the possible consequence of an increased risk of serious influenza A virus infection in people who receive treatment in methadone maintenance programs. © 2015 Society for the Study of Addiction.

  8. Does Tracing Worked Examples Enhance Geometry Learning?

    Science.gov (United States)

    Hu, Fang-Tzu; Ginns, Paul; Bobis, Janette

    2014-01-01

    Cognitive load theory seeks to generate novel instructional designs through a focus on human cognitive architecture including a limited working memory; however, the potential for enhancing learning through non-visual or non-auditory working memory channels is yet to be evaluated. This exploratory experiment tested whether explicit instructions to…

  9. A yoga program for cognitive enhancement.

    Directory of Open Access Journals (Sweden)

    Devon Brunner

    Full Text Available Recent studies suggest that yoga practice may improve cognitive functioning. Although preliminary data indicate that yoga improves working memory (WM, high-resolution information about the type of WM subconstructs, namely maintenance and manipulation, is not available. Furthermore, the association between cognitive enhancement and improved mindfulness as a result of yoga practice requires empirical examination. The aim of the present study is to assess the impact of a brief yoga program on WM maintenance, WM manipulation and attentive mindfulness.Measures of WM (Digit Span Forward, Backward, and Sequencing, and Letter-Number Sequencing were administered prior to and following 6 sessions of yoga (N = 43. Additionally, the Mindfulness Attention Awareness Scale was administered to examine the potential impact of yoga practice on mindfulness, as well as the relationships among changes in WM and mindfulness.Analyses revealed significant improvement from pre- to post- training assessment on both maintenance WM (Digit Span Forward and manipulation WM (Digit Span Backward and Letter-Number Sequencing. No change was found on Digit Span Sequencing. Improvement was also found on mindfulness scores. However, no correlation was observed between mindfulness and WM measures.A 6-session yoga program was associated with improvement on manipulation and maintenance WM measures as well as enhanced mindfulness scores. Additional research is needed to understand the extent of yoga-related cognitive enhancement and mechanisms by which yoga may enhance cognition, ideally by utilizing randomized controlled trials and more comprehensive neuropsychological batteries.

  10. An Integrated Environmental Biotechnology for Enhanced ...

    African Journals Online (AJOL)

    An enhanced in situ bioremediation of crude oil contaminated soil samples was carried out by manipulating a natural bioremediation process. In this approach, the soluble microbial products (SMPs) released during the metabolism of the polluting crude oil by hydrocarbonoclastic bacteria exemplified by Pseudomonas sp; ...

  11. Automated image enhancement using power law transformations

    Indian Academy of Sciences (India)

    Abstract. We propose a scheme for automating power law transformations which are used for image enhancement. The scheme we propose does not require the user to choose the exponent in the power law transformation. This method works well for images having poor contrast, especially to those images in which the ...

  12. Enhanced Controlled Transdermal Delivery of Torasemide Using ...

    African Journals Online (AJOL)

    Erah

    intercellular lipids to enhance drug transport across the intact skin or to increase the driving force for drug permeation. One of the most controversial methods is ..... alter the thermodynamic activity of the drugs in the vehicle, which would in turn modify the driving force for diffusion. PGs may partition into the tissue, facilitating ...

  13. Accounting for Immediate Emotional Memory Enhancement

    Science.gov (United States)

    Talmi, Deborah; McGarry, Lucy M.

    2012-01-01

    Memory for emotional events is usually very good even when tested shortly after study, before it is altered by the influence of emotional arousal on consolidation. Immediate emotion-enhanced memory may stem from the influence of emotion on cognitive processes at encoding and retrieval. Our goal was to test which cognitive factors are necessary and…

  14. Using Interdisciplinary Arts Education to Enhance Learning

    Science.gov (United States)

    Lorimer, Maureen Reilly

    2009-01-01

    Amid crossing currents of educational expectations pressing on principals, the author advocates for enhancing inclusion of the visual and performing arts. Although electives and clubs provide arts exposure to a selected few, many students do not receive consistent and high-quality arts experiences. Carefully planned, interdisciplinary arts…

  15. Enhancing Senior Secondary Students Knowledge of English ...

    African Journals Online (AJOL)

    Direct explicit and indirect explicit grammar instructional strategies enhanced students' achievement in English grammar and composition in public senior secondary schools in Ibadan metropolis. Teachers should adopt both strategies in teaching English grammar and composition for improved performance. Keywords: ...

  16. Mutation induced enhanced biosynthesis of lipase | Bapiraju ...

    African Journals Online (AJOL)

    The purpose of the present investigation is to enhance production of biomedically important enzyme lipase by subjecting the indigenous lipase producing strain Rhizopus sp. BTS-24 to improvement by natural selection and random mutagenesis (UV and N-methyl-N'-nitro-N-nitroso guanidine, NTG). The isolation of mutants ...

  17. Production enhancement partnerships -- successful business arrangements

    International Nuclear Information System (INIS)

    Coble, L.; Weitzel, K.; Attai, L.; Gray, K.

    1995-01-01

    Production enhancement projects are creating changes in business relationships between oil and gas and service companies. The most successful projects are building partnerships. Service companies are being asked to share the risk while supplying services to enhance well performance. Risk sharing creates common project objectives and requires the service company's involvement in initial project planning, job design, and reservoir understanding. Service work compensation is based on well or field performance improvement as a result of the treatment(s). This paper presents an integrated approach to the selection and prioritization of well candidates for production enhancement jobs or treatments. Special emphasis is placed on reservoir understanding using field reviews and/or extensive reservoir description studies to provide the essential information for well candidate selection and the best return on investment. Processes are illustrated and discussion gives the data requirements and techniques used to select and prioritize well candidates. Field examples demonstrate the techniques, critical factors, and appropriate software used by geoscience and field operations teams to maximize benefits from production enhancement projects

  18. Human Capital Development Policies: Enhancing Employees Satisfaction

    Science.gov (United States)

    Wan, Hooi Lan

    2007-01-01

    Purpose--The aim of this article is to gain insight into some of the human capital development (HCD) policies that enhance employee satisfaction. A salient focus of the study is to assess whether employees in globalised foreign-owned MNCs are likely to be more satisfied with the HCD policies than with the practices employed by locally owned MNCs.…

  19. Enhancement of reaction rates for catalytic benzaldehyde ...

    Indian Academy of Sciences (India)

    Abstract. The effect of pressured carbon dioxide on heterogeneous hydrogenation of benzaldehyde and homogeneous dehydration of sorbitol in water solvent was studied. Initial hydrogenation rates of benzaldehyde over a charcoal-supported palladium catalyst in water at 313 K were enhanced by the addition of carbon ...

  20. Basic Research in Plasma-Enhanced Combustion

    Science.gov (United States)

    2009-11-04

    Discharge Flow Control • Plasma Generation Ignition / Combustion• Enhancement AFOSR PROGRAM MANAGER TEAM Bob Barker Mike Berman Fariba Fahroo Arje...on Robert Mac Cormack/ Stanford Tom McLaughlin/ USAFA 0.2 0.4 MHDRobert Vidmar/Nevada, Reno Noah Herschkowitz Wisconsin Doyle Knight/ Greg Elliott

  1. Slow evaporation method and enhancement in photoluminescence ...

    Indian Academy of Sciences (India)

    amplifiers, biological fluorescence labels and drug-release schemes because nanophosphors much differ in physical and chemical properties than the bulk phosphors [1–4]. Thus, now-a-days, the practical world demands for highly efficient nanophosphors and hence enhancement in synthesis routes and their fluorescence ...

  2. Enhanced muscle glucose metabolism after exercise

    DEFF Research Database (Denmark)

    Richter, Erik; Garetto, L P; Goodman, M N

    1984-01-01

    Studies in the rat suggest that after voluntary exercise there are two phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase in the pr......Studies in the rat suggest that after voluntary exercise there are two phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase...... in the stimulated leg closely mimicked that observed previously after voluntary exercise on a treadmill. With no insulin added to the perfusate, glucose incorporation into glycogen was markedly enhanced in muscles that were glycogen depleted as were the uptake of 2-deoxyglucose and 3-O-methylglucose. Likewise......, the stimulation of these processes by insulin was enhanced and continued to be so 2 h later when the muscles of the stimulated leg had substantially repleted their glycogen stores. The results suggest that the increases in insulin-mediated glucose utilization and glycogen synthesis in muscle after exercise...

  3. Design-Oriented Enhanced Robotics Curriculum

    Science.gov (United States)

    Yilmaz, M.; Ozcelik, S.; Yilmazer, N.; Nekovei, R.

    2013-01-01

    This paper presents an innovative two-course, laboratory-based, and design-oriented robotics educational model. The robotics curriculum exposed senior-level undergraduate students to major robotics concepts, and enhanced the student learning experience in hybrid learning environments by incorporating the IEEE Region-5 annual robotics competition…

  4. The Skills Enhancement Training Program. Performance Report.

    Science.gov (United States)

    Food and Beverage Workers Union, Local 32, Washington, DC.

    This report describes a joint labor-management workplace literacy program called SET (Skills Enhancement Training) that targeted the more than 2,000 unionized employees of food service contractors at U.S. government institutions in Washington, D.C. Nineteen classes were offered and a total of 191 people self-selected themselves into the program.…

  5. Topology Optimized Nanostrips for Electric Field Enhancements

    DEFF Research Database (Denmark)

    Vester-Petersen, Joakim; Christiansen, Rasmus E.; Julsgaard, Brian

    energy photons are converted to higher energy photons able to bridge the band gap energy and contribute the energy generation. The upconversion process in erbium is inefficient under the natural solar irradiation, and without any electric field enhancements of the incident light, the process...

  6. Enhancing Fieldwork Learning with Technology: Practitioner's Perspectives

    Science.gov (United States)

    Welsh, Katharine E.; Mauchline, Alice L.; Park, Julian R.; Whalley, W. Brian; France, Derek

    2013-01-01

    This research paper reports the findings from an international survey of fieldwork practitioners on their use of technology to enhance fieldwork teaching and learning. It was found that there was high information technology usage before and after time in the field, but some were also using portable devices such as smartphones and global…

  7. Enhancing Instructional Time through Attention to Metacognition.

    Science.gov (United States)

    Palincsar, Annemarie Sullivan; Brown, Deborah A.

    1987-01-01

    The literature on metacognition and students having learning problems is reviewed. Investigations of metacognitive instruction to enhance memory skills, to increase text comprehension, and to improve written expression and math performance are reported. The roles of the teacher and learner in acquiring and controlling the targeted cognitive…

  8. Enhanced Phagocytosis and Antibody Production by Tinospora ...

    African Journals Online (AJOL)

    Tinospora cordifolia (guduchi) is a widely used shrub in ayurvedic systems of medicine known to possess immunomodulatory properties. In the present study the aqueous extract of T. cordifolia was found to enhance phagocytosis in vitro. The aqueous and ethanolic extracts also induced an increase in antibody production ...

  9. Recommendations for communication to enhance informed consent ...

    African Journals Online (AJOL)

    Recommendations for communication to enhance informed consent and enrolment at multilingual research sites. Claire Penn, Melanie Evans. Abstract. Language issues can affect HIV and AIDS research trial enrolment, but little is understood about variables in this process. Some evidence indicates barriers exist even ...

  10. Enhancing ecosystem services: Designing for multifunctionality

    Science.gov (United States)

    Mike Dosskey; Gary Wells; Gary Bentrup; Doug Wallace

    2012-01-01

    It is increasingly recognized that ecosystem services provide a foundation for the well-being of individuals and society (MEA 2005). Land managers typically strive to enhance particularly desirable services. For example, farmers plant crops and manage the soil and hydrologic conditions to favor crop production. In agricultural regions such as the US Corn Belt,...

  11. assessing participation in secondary education quality enhancement

    African Journals Online (AJOL)

    PROF. BARTH EKWEME

    and parents of students in public secondary schools were used. A total of 8,590 ... activities. The teacher's role in enhancing the quality of education is quite crucial since learning in the school system does not occur in a vacuum. Perhaps, this is the basis of the axiom that a .... have low education get more money and.

  12. Long Wave Infrared Cavity Enhanced Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Taubman, Matthew S.; Scott, David C.; Cannon, Bret D.; Myers, Tanya L.; Bonebrake, Christopher A.; Aker, Pam M.; Wojcik, Michael D.; Munley, John T.; Nguyen, Vinh T.; Schultz, John F.

    2004-10-01

    The principal goal of Pacific Northwest National Laboratory's (PNNL's) long wave infrared (LWIR) cavity enhanced sensor (CES) project is to explore ultra-sensitive spectroscopic techniques and apply them to the development of LWIR chemical sensors needed for detecting weapons proliferation. This includes detecting not only the weapons of mass destruction (WMDs) themselves, but also signatures of their production and/or detonation. The LWIR CES project is concerned exclusively with developing point sensors; other portions of PNNL's IR Sensors program address stand off detection. PNNL's LWIR CES research is distinguished from that done by others by the use quantum cascade lasers (QCLs) as the light source. QCLs are novel devices, and a significant fraction of our research has been devoted to developing the procedures and hardware required to implement them most effectively for chemical sensing. This report details the progress we have made on our LWIR CES sensor development. During FY02, PNNL investigated three LWIR CES implementations beginning with the easiest to implement, direct cavity-enhanced detection (simple CES), including a technique of intermediate difficulty, cavity-dithered phase-sensitive detection (FM recovery CES) through to the most complex technique, that of resonant sideband cavity-enhanced detection also known as noise-immune cavity-enhanced optical heterodyne molecular spectroscopy, or NICE-OHMS.

  13. Spontaneous emission enhancement of colloidal perovskite nanocrystals

    Science.gov (United States)

    Yang, Zhili; Waks, Edo

    Halide perovskite semiconductors have emerged as prominent photovoltaic materials since their high conversion efficiency and promising light emitting materials in optoelectronics. In particular, easy-to-fabricated colloidal perovskite nanocrystals based on CsPbX3 quantum dots has been intensively investigated recently. Their luminescent wavelength could be tuned precisely by their chemical composition and size of growth. This opens new applications including light-emitting diodes, optical amplifiers and lasing since their promising performance as emitters. However, this potentially high-efficient emitter and gain material has not been fully investigated and realized in integrated photonic structures. Here we demonstrate Purcell enhancement effect of CsPbBr3 perovskite nanocrystals by coupling to an optimized photonic crystal nanobeam cavity as a first crucial step towards realization of integrated on-chip coherent light source with low energy consumption. We show clearly highly-enhanced photoluminescent spectrum and an averaged Purcell enhancement factor of 2.9 is achieved when they are coupled to nanobeam photonic crystal cavities compared to the ones on unpatterned surface in our lifetime measurement. Our success in enhancement of emission from CsPbX3 perovskite nanocrystals paves the way towards the realization of efficient light sources for integrated optoelectronic devices with low energy consumption.

  14. Enhancing Organizational Performance: A Toolbox for Self ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Do you know if your organization is performing efficiently? If it isn't, do you know why? This guidebook presents an innovative and thoroughly tested model for organizational self-assessment. The tools and tips in Enhancing Organizational Performance go beyond measuring the impact of programs, products, and services.

  15. Enhancing youth employability in Zambia | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2015-12-16

    Dec 16, 2015 ... Read the brief, Enhancing youth employability: Zambia (PDF, 764 KB); Read full report, Youth employment challenges in Zambia: A statistical profile, current policy frameworks and existing interventions (PDF 1.71 MB); For a visual representation of the key findings see the infographic poster (PDF, 282 KB).

  16. Guidelines for enhancing clinical supervision: research ...

    African Journals Online (AJOL)

    A qualitative, exploratory and descriptive research design was utilised where results from narrative sketches and literature control served as the basis for deducting and describing guidelines for enhancing reflection during the process of supervision. The conclusions drawn from the related findings are that the respondents ...

  17. Enhanced recovery programme in robotic hysterectomy.

    Science.gov (United States)

    Iavazzo, Christos; Gkegkes, Ioannis D

    The standard care for endometrial cancer includes total hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings with or without bilateral pelvic and/or paraaortic lymph node dissection/sampling with or without omental biopsy or omentectomy. The aim of this narrative review is to present the advantages of robotic surgery in combination with the enhanced recovery programme to offer better care to patients with endometrial cancer. The authors argue that a well-organised service for robotic hysterectomy should be set up in all hospitals. As part of this, an enhanced recovery programme including the following elements should be implemented: patient education, preoperative carbohydrate drinks, spinal or local analgesia, goal-directed fluid therapy, early feeding and intensive early mobilisation. The enhanced recovery programme includes pre, intra and postoperative changes in patient management. A comprehensive enhanced recovery programme starting in the preoperative setting and extending through to the patient's discharge, combined with robotic approach, could lead to optimal care of patients with endometrial cancer.

  18. From student feedback to institutional quality enhancement ...

    African Journals Online (AJOL)

    From student feedback to institutional quality enhancement initiatives that focus on supporting staff and students. ... reasons for a particular set of circumstances, planning and implementation of changes in a generally fluid situation, collection of evidence for outcomes, and provision of succinct reports to stakeholders.

  19. Didactic Experiments Suggest Enhanced Learning Outcomes

    DEFF Research Database (Denmark)

    Pals Svendsen, Lisbet

    2011-01-01

    and presenting material in the language studied, just as they were encouraged to systematically use evaluation processes to enhance learning outcomes. Eventually, increased grade point averages suggested that the experiment was successful. The article also mentions subsequent revisions to the original format...... and points the way for further research....

  20. Yes, Classroom Sales Training Can Enhance Performance.

    Science.gov (United States)

    Graham, Steven W.; Wedman, John; Monahan, Carol; Tanner, Tom

    1998-01-01

    Discusses learning in organizations, competitiveness, and training effectiveness. Describes a study that was conducted to determine if it is possible to link sales production to participation in classroom sales training, and if so, what elements seem to be most useful in enhancing employee performance and sales performance. (Author/LRW)