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  1. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    Science.gov (United States)

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

  2. Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

    Science.gov (United States)

    Umar, Asad; Boland, C. Richard; Terdiman, Jonathan P.; Syngal, Sapna; de la Chapelle, Albert; Rüschoff, Josef; Fishel, Richard; Lindor, Noralane M.; Burgart, Lawrence J.; Hamelin, Richard; Hamilton, Stanley R.; Hiatt, Robert A.; Jass, Jeremy; Lindblom, Annika; Lynch, Henry T.; Peltomaki, Païvi; Ramsey, Scott D.; Rodriguez-Bigas, Miguel A.; Vasen, Hans F. A.; Hawk, Ernest T.; Barrett, J. Carl; Freedman, Andrew N.; Srivastava, Sudhir

    2010-01-01

    Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and because of the need for a better understanding of the clinical and histologic manifestations of HNPCC, the National Cancer Institute hosted an international workshop on HNPCC in 1996, which led to the development of the Bethesda Guidelines for the identification of individuals with HNPCC who should be tested for MSI. To consider revision and improvement of the Bethesda Guidelines, another HNPCC workshop was held at the National Cancer Institute in Bethesda, MD, in 2002. In this commentary, we summarize the Workshop presentations on HNPCC and MSI testing; present the issues relating to the performance, sensitivity, and specificity of the Bethesda Guidelines; outline the revised Bethesda Guidelines for identifying individuals at risk for HNPCC; and recommend criteria for MSI testing. PMID:14970275

  3. El Sistema Bethesda 2001 The 2001 Bethesda System

    Directory of Open Access Journals (Sweden)

    Christine Bergeron

    2003-01-01

    Full Text Available The Bethesda system is a system of terminology for reporting the results of cervical cytology. It was developed in 1988, and is now widely used in the United States. This system was updated in April 2001. The most important modifications are the following: a elimination of the category "satisfactory but limited by", b the reintegration of benign modifications in the normal category, c "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d endocervical adenocarcinoma in situ which is now a separate entity. Low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. Recommendations have been proposed concerning automated review and ancillary testing.El Sistema Bethesda es un sistema de terminología para informar los resultados de citología cervical. Se inició en 1988 y en la actualidad se usa en todos los Estados Unidos de América. Este sistema se actualizó en abril de 2001. Las modificaciones más importantes son las siguientes: a eliminación de la categoría "satisfactorio pero limitado por", b se reintegraron las modificaciones benignas en la categoría normal, c la categoría "células escamosas atípicas de significado indeterminado" ahora se denomina "células escamosas atípicas", y se subdivide en "células escamosas atípicas de significado indeterminado" y "no se puede excluir una lesión escamosa de alto grado", y d adenocarcinoma endocervical in situ, que ahora es una entidad separada. Las lesiones escamosas intraepiteliales de bajo y alto grado quedan sin cambios. Se proponen recomendaciones relacionadas con el uso de la revisión automatizada y la utilización de pruebas auxiliares.

  4. About the Eye

    Medline Plus

    Full Text Available ... Lane, MSC 9300 Bethesda, MD 20892-9300 (Courier services use: Rockville, MD 20852) 301-451-2020 Research ... NEI Website Manager . Department of Health and Human Services | The National Institutes of Health | USA.gov NIH… ...

  5. How Loud Is Too Loud?

    Medline Plus

    Full Text Available ... Health and Human Services National Institutes of Health USA.gov—Government Made Easy NIH… Turning Discovery Into ... Disorders 31 Center Drive, MSC 2320, Bethesda, MD USA 20892-2320 Email: nidcdinfo@nidcd.nih.gov NIDCD ...

  6. Pseudomonas aeruginosa induces pigment production and enhances virulence in a white phenotypic variant of Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Antonic V

    2013-11-01

    Full Text Available Vlado Antonic,1–3 Alexander Stojadinovic,3–5 Binxue Zhang,1–3 Mina J Izadjoo,1–3,5 Mohammad Alavi1–3 1Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; 2Diagnostic and Translational Research Center, Gaithersburg, MD, USA; 3Combat Wound Initiative Program, Bethesda, MD, USA; 4Walter Reed National Military Medical Center, Bethesda, MD, USA; 5Uniformed Services University of the Health Sciences, Bethesda, MD, USA Abstract: Staphyloxanthin is a virulence factor which protects Staphylococcus aureus in stress conditions. We isolated two pigment variants of S. aureus and one strain of Pseudomonas aeruginosa from a single wound infection. S. aureus variants displayed white and yellow colony phenotypes. The sequence of the operons for staphyloxanthin synthesis indicated that coding and promoter regions were identical between the two pigment variants. Quorum sensing controls pigment synthesis in some bacteria. It is also shown that P. aeruginosa quorum-sensing molecules affect S. aureus transcription. We explored whether the co-infecting P. aeruginosa can affect pigment production in the white S. aureus variant. In co-culture experiments between the white variants and a selected number of Gram-positive and Gram-negative bacteria, only P. aeruginosa induced pigment production in the white variant. Gene expression analysis of the white variant did not indicate upregulation of the crtM and other genes known to be involved in pigment production (sigB, sarA, farnesyl pyrophosphate synthase gene [FPP-synthase], hfq. In contrast, transcription of the catalase gene was significantly upregulated after co-culture. P. aeruginosa-induced pigment synthesis and catalase upregulation correlated with increased resistance to polymyxin B, hydrogen peroxide, and the intracellular environment of macrophages. Our data indicate the presence of silent but functional staphyloxanthin synthesis machinery in a white phenotypic variant

  7. Prospective post traumatic stress disorder symptom trajectories in active duty and separated military personnel

    Science.gov (United States)

    2017-01-30

    Center, San Diego, CA, USA b The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA c Teachers College, Columbia...Gordon Lynch; Denise Lovec- Jenkins ; Rayna Matsuno PhD; Danielle Mitchell; Kristin Motylinski; Anna Nagel MPH; Chiping Nieh PhD; Chris O’Malley MPH

  8. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... Department of Health and Human Services National Institutes of Health USA.gov The ...

  9. Development of the Young Brain

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... Department of Health and Human Services National Institutes of Health USA.gov The ...

  10. Development of the Young Brain

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... U.S. Department of Health and Human Services National Institutes of Health USA.gov The ...

  11. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... U.S. Department of Health and Human Services National Institutes of Health USA.gov The ...

  12. Reliability of Multiple Component Systems

    Science.gov (United States)

    1975-07-15

    George Washington University Bethesda, Maryland .20014 Dr. Larry Cornwell Western Illinois University Macomb, Illinois 61455 Dr. Lester A...Jersey 07801 Robert M. Eissner USA Materiel Sys Anal Agency Aberdeen Proving Ground, Md. 21005 Bernard Engebos USA Electronics Command White...Philadelphia, Pennsylvania 19137 587 J Attendee»-- 19lh Design of Experiments Conference (continued) Captain Bernard J. Lawless Hqs

  13. How Loud Is Too Loud?

    Medline Plus

    Full Text Available ... of hearing loss in women: Patterns of healthy eating may lower risk of hearing loss by 30 percent ... Health ® National Institute on Deafness and Other Communication Disorders 31 Center Drive, MSC 2320, Bethesda, MD USA ...

  14. Genetics Home Reference: leukoencephalopathy with vanishing white matter

    Science.gov (United States)

    ... Torres C, Pröschel C. EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy. Nat Med. ... of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, Bethesda, MD 20894, USA HONCode ...

  15. Morgellons disease: a filamentous borrelial dermatitis

    OpenAIRE

    Middelveen, Marianne J; Stricker, Raphael B

    2016-01-01

    Marianne J Middelveen, Raphael B Stricker International Lyme and Associated Diseases Society, Bethesda, MD, USA Abstract: Morgellons disease (MD) is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they resu...

  16. Dynamical complexity and temporal plasticity in pancreatic ββ-cells

    Indian Academy of Sciences (India)

    Author Affiliations. Richard Bertram1 2 Arthur Sherman1 2. Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA; Mathatical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA ...

  17. How Loud Is Too Loud?

    Medline Plus

    Full Text Available ... Publications Content Syndication U.S. Department of Health and Human Services National Institutes of Health USA.gov—Government Made Easy NIH… Turning Discovery Into Health ® National Institute on Deafness and Other Communication Disorders 31 Center Drive, MSC 2320, Bethesda, MD ...

  18. An Integrated Modeling and Observational Study of Three-Dimensional Upper Ocean Boundary Layer Dynamics and Parameterizations

    Science.gov (United States)

    2012-04-26

    for public release ; distribution is unlimited. 4 Figure 3. First Kuroshio survey. Colors show MODIS SST image. Inset shows the survey...Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. *To whom correspondence should be addressed. E-mail: stevens@scripps.edu 15

  19. The vaginal microbiota: what have we learned after a decade of molecular characterization?

    NARCIS (Netherlands)

    van de Wijgert, Janneke H. H. M.; Borgdorff, Hanneke; Verhelst, Rita; Crucitti, Tania; Francis, Suzanna; Verstraelen, Hans; Jespers, Vicky

    2014-01-01

    We conducted a systematic review of the Medline database (U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD, U.S.A) to determine if consistent molecular vaginal microbiota (VMB) composition patterns can be discerned after a decade of molecular testing, and to evaluate

  20. New Fellows and Honorary Fellow

    Indian Academy of Sciences (India)

    Ganapathi, Dr Krishnamurthy D.Sc. (Madras), FNA. Date of birth: 18 August 1911. Date of death: 15 October 2004. Specialization: Microbial Biochemistry, Fermentation Technology and Chemotherapy Last known address: c/o Dr L. Sankaran, 5809, Ipswich Road, Bethesda, MD 20814, USA. YouTube; Twitter; Facebook ...

  1. 77 FR 63842 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-17

    ... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD....m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  2. 75 FR 1399 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-11

    ... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person... Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Syed M... a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M...

  3. Psychotherapies

    Science.gov (United States)

    ... and Secure from the Department of Health and Human Services Understanding Mobile Apps from OnGuardOnline.gov Information on mobile ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... U.S. Department of Health and Human Services National Institutes of Health USA.gov The ...

  4. miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis ...

    Indian Academy of Sciences (India)

    Qi-Shun Zhang

    2017-07-20

    Jul 20, 2017 ... through down-regulation of SIRT1 in Alzheimer's disease. QI-SHUN ... purpose of this study was to examine whether miR-200a-3p regulated ... miR-29b-1 can modulate b-site amyloid precursor protein- ... multiple important cellular processes, including cell meta- .... Institutes of Health, Bethesda, MD, USA).

  5. Use of Performance Measures to Evaluate, Document Competence and Deterioration of Advanced Surgical Skills Exposure for Trauma (ASSET) Surgical Skills

    Science.gov (United States)

    2015-03-01

    Sharon Henry1, Stacy Shackelford4. 1Shock Trauma Anesthesiology Research, University of Maryland Baltimore; 2The Alfred Hospital and Swinburne...Bethesda USA, The Alfred Hospital and Swinburne University, Melbourne, Australia • 6) THE ASSETS OF ASSET: IMPROVING SURGICAL PERFROMANCE...ACTIVITY 820 CHANDLER STREET FORT DETRICK MD 21702-5014 January 15, 2015 SUBJECT: BA 150077- "Refreshing Combat Surgical Skills for Vascular Control

  6. Diagnostic accuracy of circulating thyrotropin receptor messenger RNA combined with neck ultrasonography in patients with Bethesda III-V thyroid cytology.

    Science.gov (United States)

    Aliyev, Altay; Patel, Jinesh; Brainard, Jennifer; Gupta, Manjula; Nasr, Christian; Hatipoglu, Betul; Siperstein, Allan; Berber, Eren

    2016-01-01

    The aim of this study was to analyze the usefulness of thyrotropin receptor messenger RNA (TSHR-mRNA) combined with neck ultrasonography (US) in the management of thyroid nodules with Bethesda III-V cytology. Cytology slides of patients with a preoperative fine needle aspiration (FNA) and TSHR-mRNA who underwent thyroidectomy between 2002 and 2011 were recategorized based on the Bethesda classification. Results of thyroid FNA, TSHR-mRNA, and US were compared with the final pathology. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. There were 12 patients with Bethesda III, 112 with Bethesda IV, and 58 with Bethesda V cytology. The sensitivity of TSHR-mRNA in predicting cancer was 33%, 65%, and 79 %, and specificity was 67%, 66%, and 71%, for Bethesda III, IV, and V categories, respectively. For the same categories, the PPV of TSHR-mRNA was 25%, 33%, and 79%, respectively; whereas the NPV was 75%, 88%, and 71%, respectively. The addition of neck US to TSHR-mRNA increased the NPV to 100% for Bethesda III, and 86%, for Bethesda IV, and 82% for Bethesda V disease. This study documents the potential usefulness of TSHR-mRNA for thyroid nodules with Bethesda III-V FNA categories. TSHR-mRNA may be used to exclude Bethesda IV disease. A large sample analysis is needed to determine its accuracy for Bethesda category III nodules. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Transactions of the twenty-third water reactor safety information meeting to be held at Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Monteleone, S. [comp.

    1995-09-01

    This report contains summaries of papers on reactor safety research to be presented at the 23rd Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory, Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningful discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session.

  8. Transactions of the twenty-third water reactor safety information meeting to be held at Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995

    International Nuclear Information System (INIS)

    Monteleone, S.

    1995-09-01

    This report contains summaries of papers on reactor safety research to be presented at the 23rd Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory, Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningful discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session

  9. A Clinician-Centered Evaluation of the Usability of AHLTA and Automated Clinical Practice Guidelines at TAMC

    Science.gov (United States)

    2009-10-01

    gathering has been rescheduled to November 14, 2009, in San Francisco, at the AMIA Conference location. August 14, 2009, SOADEX provided a draft system...Bethesda. MD, USA d Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Austria • Department of Nursing . lnha University...scheduled. Insook Cho, PhD, RN Associate Professor, Maternity Nursing & Nursing Informat- ics, lnha University, Younghyun-dong, Nam-gu, Jncheon, South

  10. Promoting family meals: a review of existing interventions and opportunities for future research

    Directory of Open Access Journals (Sweden)

    Dwyer L

    2015-06-01

    Full Text Available Laura Dwyer,1 April Oh,2 Heather Patrick,1,3 Erin Hennessy4 1Health Behaviors Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA; 2Health Communication and Informatics Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA; 3Live Healthier, Bethesda, MD, USA; 4Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA Abstract: Evidence suggests that regular family meals protect against unhealthy eating and obesity during childhood and adolescence. However, there is limited information on ways to promote family meals as part of health promotion and obesity prevention efforts. The primary aim of this review was to synthesize the literature on strategies to promote family meals among families with school-aged children and adolescents. First, we reviewed interventions that assess family meals as an outcome and summarized strategies that have been used in these interventions. Second, we reviewed correlates and barriers to family meals to identify focal populations and target constructs for consideration in new interventions. During May 26–27, 2014, PubMed and PsycInfo databases were searched to identify literature on family meals published between January 1, 2000 and May 27, 2014. Two reviewers coded 2,115 titles/abstracts, yielding a sample of 139 articles for full-text review. Six interventions and 43 other studies presenting data on correlates of or barriers to family meals were included in the review. Four interventions resulted in greater family meal frequency. Although there were a small number of interventions, intervention settings were diverse and included the home, community, medical settings, the workplace, and the Internet. Common strategies were

  11. Risk mitigation strategies for viral contamination of biotechnology products: consideration of best practices.

    Science.gov (United States)

    Rosenberg, Amy S; Cherney, Barry; Brorson, Kurt; Clouse, Kathleen; Kozlowski, Steven; Hughes, Patricia; Friedman, Rick

    2011-01-01

    CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Viral contamination of biotech product facilities is a potentially devastating manufacturing risk and, unfortunately, is more common than is generally reported or previously appreciated. Although viral contaminants of biotech products are thought to originate principally from biological raw materials, all potential process risks merit evaluation. Limitations to existing methods for virus detection are becoming evident as emerging viruses have contaminated facilities and disrupted supplies of critical products. New technologies, such as broad-based polymerase chain reaction screens for multiple virus types, are increasingly becoming available to detect adventitious viral contamination and thus, mitigate risks to biotech products and processes. Further, the industry embrace of quality risk management that promotes improvements in testing stratagems, enhanced viral inactivation methods for raw materials, implementation and standardization of robust viral clearance procedures, and efforts to learn from both epidemiologic screening of raw material sources and from the experience of other manufacturers with regard to this problem will serve to enhance the safety of biotech products available to patients. Based on this evolving landscape, we propose a set of principles for manufacturers of biotech products: Pillars of Risk Mitigation for Viral Contamination of Biotech Products.

  12. 77 FR 68136 - National Cancer Institute Amended; Notice of Meeting

    Science.gov (United States)

    2012-11-15

    ... Regency Bethesda Hotel, Old Georgetown Room, One Metro Center, Bethesda, MD 20814. The NCAB ad hoc... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute..., Building 31C, Wing C, Conference Room 10, 31 Center Drive, Bethesda, MD 20892 which was published in the...

  13. 77 FR 66623 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2012-11-06

    ... and Health Disparities Special Emphasis Panel; NIMHD Community-Based Participatory Research (CBPR... Marriott Suites, 6711 Democracy Boulevard, Bethesda, MD 20817. Contact Person: Robert Nettey, M.D., Chief... of Health, 6707 Democracy Blvd., Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

  14. Efficiency of the Bethesda System for Thyroid Cytopathology.

    Science.gov (United States)

    Mora-Guzmán, Ismael; Muñoz de Nova, José Luis; Marín-Campos, Cristina; Jiménez-Heffernan, José Antonio; Cuesta Pérez, Juan Julián; Lahera Vargas, Marcos; Torres Mínguez, Emma; Martín-Pérez, Elena

    2018-03-28

    Fine-needle aspiration biopsies are a key tool for preoperative assessment of thyroid nodules, and the Bethesda system is the preferred method to report cytological analysis. The purpose of this study is to assess the efficiency of the Bethesda system to identify the malignancy risk of thyroid nodules. Patients who underwent thyroid surgery between June 2010 and June 2017 were included. Samples were classified into 6categories according to rates of malignancy associated with each diagnostic category. In order to investigate the correlation between categories, a statistical analysis compared the categories with pathology reports. Diagnostic indicators were calculated as a screening test (categories IV, V, VI as true-positive) and as a method to identify malignancy (V, VI as true-positive). In a series of 522 patients, we found 184 (35.2%) malignant tumours, papillary carcinoma being the most prevalent with 155 cases (84.2%). Malignant rates for diagnostic categories were: I, 0%; II, 1.5%; III, 6.4%; IV, 31%; V, 86.5%; VI, 100%. A robust correlation was identified between categories on statistical analysis. For the «screening test» analysis, sensitivity was 98.9%, specificity 84.4%, positive predictive value 69.6%, negative predictive value 99.5%, and diagnostic accuracy 88.2%. Analysing the accuracy to detect malignancy, values were: sensitivity 98.6%, specificity 97.6%, positive predictive value 93.5%, negative predictive value 99.5%, diagnostic accuracy 97.9%. The Bethesda system is a clear and reliable approach to report thyroid cytology and therefore is an effective tool to identify malignancy risk and guide clinical management. Copyright © 2018 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. The Bethesda system for reporting thyroid fine needle aspirates: A cytologic study with histologic follow-up

    Directory of Open Access Journals (Sweden)

    Santosh Kumar Mondal

    2013-01-01

    Conclusions: Reviewing the thyroid FNAs with the Bethesda system allowed a more specific cytological diagnosis. In this study, the distribution of cases in the Bethesda categories differed from some studies, with the number of benign cases being higher and the number of non-diagnostic and AFLUS cases being lower. The malignancy risk for each category correlated well with other studies. The Bethesda system thus allows standardization in reporting, improves perceptions of diagnostic terminology between cytopathologists and clinicians, and leads to more consistent management approaches.

  16. Harold E. Varmus, MD.

    Science.gov (United States)

    Varmus, H E

    1995-06-01

    On November 19, 1993, the Senate approved the nomination of Harold E. Varmus, MD, as Director of the National Institutes of Health (NIH). Varmus, who received the 1989 Nobel Prize in Medicine, brought unquestioned credentials as a scientist to the NIH. Despite his limited background as an administrator, Varmus has received high marks from most observers for improving the morale of NIH staffers and implementing streamlined procedures in the grant review process. His tenure has not been free of controversy, however. Many clinical researchers have long felt there is a bias in NIH study sections against patient-oriented research. A recent study sponsored by the Division of Research Grants confirmed the lower success rate of patient-oriented research proposals, but the outcome of these findings remains unclear. Faced with mounting political pressure for a balanced budget, and the resultant reduction of funding to many branches of government, Varmus has been a strong voice for non-targeted investigator initiated research. Interviewed in his office in Building One on the NIH campus in Bethesda, Maryland, Varmus discussed the state of patient oriented research, the evolving role of the NIH in supporting science, and just where the money to pay for it should be found.

  17. 78 FR 60297 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-10-01

    ..., Rockville, MD 20852. Contact Person: Leonid V. Tsap, Ph.D., Scientific Review Officer, Center for Scientific...: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Patrick K Lai, Ph.D...

  18. The 2001 Bethesda System

    Directory of Open Access Journals (Sweden)

    Bergeron Christine

    2003-01-01

    Full Text Available The Bethesda system is a system of terminology for reporting the results of cervical cytology. It was developed in 1988, and is now widely used in the United States. This system was updated in April 2001. The most important modifications are the following: a elimination of the category "satisfactory but limited by", b the reintegration of benign modifications in the normal category, c "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d endocervical adenocarcinoma in situ which is now a separate entity. Low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. Recommendations have been proposed concerning automated review and ancillary testing.

  19. Characterization and evolution of dermal filaments from patients with Morgellons disease

    OpenAIRE

    Middelveen, Marianne J; Mayne, Peter J; Kahn, Douglas G; Stricker, Raphael B

    2013-01-01

    Marianne J Middelveen,1 Peter J Mayne,1 Douglas G Kahn,2 Raphael B Stricker11International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Department of Pathology, Olive View–UCLA Medical Center, Sylmar, CA, USAAbstract: Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either s...

  20. Morgellons disease: Analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology

    OpenAIRE

    Savely, Virginia R; Stricker, Raphael B

    2010-01-01

    Virginia R Savely1, Raphael B Stricker21TBD Medical Associates, San Francisco, CA, USA; 2International Lyme and Associated Diseases Society, Bethesda, MD, USABackground: Morgellons disease is a controversial illness in which patients complain of stinging, burning, and biting sensations under the skin. Unusual subcutaneous fibers are the unique objective finding. The etiology of Morgellons disease is unknown, and diagnostic criteria have yet to be established. Our goal was to identify prevalen...

  1. Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer

    Science.gov (United States)

    2012-09-01

    expression in prostate cancer (4). Lower or no ERG expression in a subset of aggressive tumors with TMPRSS2-ERG fusion may reflect attenuation of androgen...Services University of the Health Sciences, Bethesda MD 20814, USA 2. Cancer Vaccine Development Laboratory, Department of Surgery, United...negative for ERG. The ERG MAb did not show cross reactivity to FLI-1 in LNCaP cells infected with a FLI-1 adenovirus expression vector (Fig 1A

  2. The nurse entrepreneur: empowerment needs, challenges, and self-care practices

    OpenAIRE

    Vannucci,Marla J; Weinstein,Sharon M

    2017-01-01

    Marla J Vannucci,1 Sharon M Weinstein2 1Psychology Department, Adler University, Chicago, IL, 2SMW Group, North Bethesda, MD, USA Abstract: The purpose of this exploratory study was to better understand the experiences and challenges of nurse entrepreneurs. Nurse entrepreneurs (N=44) reported on their transitions from employment to entrepreneurship, key motivators in the decision to start a business, and the challenges they face as entrepreneurs in the health care field. Additionally, partici...

  3. Second edition of 'The Bethesda System for reporting cervical cytology' – atlas, website, and Bethesda interobserver reproducibility project

    Directory of Open Access Journals (Sweden)

    Nayar Ritu

    2004-10-01

    Full Text Available Abstract A joint task force of the American Society of Cytopathology (ASC and the National Cancer Institute (NCI recently completed a 2-year effort to revise the Bethesda System "blue book" atlas and develop a complementary web-based collection of cervical cytology images. The web-based collection of images is housed on the ASC website, which went live on November 5th, 2003; it can be directly accessed at http://www.cytopathology.org/NIH/.

  4. Clinical Trials

    Medline Plus

    Full Text Available ... studies. View funding information for clinical trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn ... and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn ...

  5. Clinical Trials

    Medline Plus

    Full Text Available ... trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Get ... and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Connect ...

  6. [MD PhD programs: Providing basic science education for ophthalmologists].

    Science.gov (United States)

    Spaniol, K; Geerling, G

    2015-06-01

    Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

  7. Iron-Deficiency Anemia

    Medline Plus

    Full Text Available ... Iron-Deficiency Anemia (National Library of Medicine, MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn ... and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn ...

  8. Iron-Deficiency Anemia

    Medline Plus

    Full Text Available ... Medicine, MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Get ... and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Connect ...

  9. 76 FR 55076 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2011-09-06

    ... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, Bethesda, MD 20814. Contact Person... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC...

  10. 77 FR 35417 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-13

    .... Place: St. Gregory Hotel, 2033 M Street NW., Washington, DC 20036. Contact Person: Geoffrey G Schofield... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD...

  11. Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.

    Science.gov (United States)

    Joseph, Jeymohan; Cinque, Paola; Colosi, Deborah; Dravid, Ameet; Ene, Luminita; Fox, Howard; Gabuzda, Dana; Gisslen, Magnus; Beth Joseph, Sarah; Letendre, Scott; Mukerji, Shibani S; Nath, Avindra; Perez-Valero, Ignacio; Persaud, Deborah; Price, Richard W; Rao, Vasudev R; Sacktor, Ned; Swanstrom, Ronald; Winston, Alan; Wojna, Valerie; Wright, Edwina; Spudich, Serena

    2016-10-05

    CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

  12. 76 FR 372 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-04

    ... 7770, Bethesda, MD 20892, (301) 435- 0684, [email protected] . Name of Committee: Oncology 1--Basic..., Bethesda, MD 20892, 301-495- 1718, [email protected] . Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group; Synthetic and Biological Chemistry B Study Section. Date...

  13. 77 FR 58852 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-24

    ...: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  14. 77 FR 6809 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-09

    ... 7770, Bethesda, MD 20892, 301 806-0009, [email protected]csr.nih.gov . Name of Committee: Healthcare..., Room 3166, MSC 7770, Bethesda, MD 20892, 301-254-9975, [email protected]csr.nih.gov . Name of Committee... Committee: Healthcare Delivery and Methodologies Integrated Review Group Community-Level Health Promotion...

  15. 75 FR 13136 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

  16. 78 FR 27247 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-09

    ... 5176 MSC 7844, Bethesda, MD 20892, (301) 435-1713, [email protected]csr.nih.gov . Name of Committee: Healthcare Delivery and Methodologies Integrated Review Group; Community-Level Health Promotion Study Section. Date... Rockledge Drive, Room 3166, Bethesda, MD 20892, 301-451-8428, [email protected]csr.nih.gov . Name of Committee...

  17. Structural and Functional Studies on the Fusion and Attachment Envelope Glycoproteins of Nipah Virus and Hendra Virus

    Science.gov (United States)

    2003-01-01

    including measles virus (MeV), mumps virus, Sendai virus (SeV), Newcastle disease virus (NDV), rinderpest virus, canine distemper virus (CDV), human...Institute of Health, Bethesda, MD. Hut 102, MT2, MT4, and CEM human T cell lines were provided by Chou-Zen Giam, USUHS, Bethesda, MD. The human osteosarcoma

  18. Morgellons disease: a filamentous borrelial dermatitis

    Directory of Open Access Journals (Sweden)

    Middelveen MJ

    2016-10-01

    Full Text Available Marianne J Middelveen, Raphael B Stricker International Lyme and Associated Diseases Society, Bethesda, MD, USA Abstract: Morgellons disease (MD is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they result from proliferation of keratinocytes and fibroblasts in epithelial tissue. Culture, histopathological and molecular evidence of spirochetal infection associated with MD has been presented in several published studies using a variety of techniques. Spirochetes genetically identified as Borrelia burgdorferi sensu stricto predominate as the infective agent in most of the Morgellons skin specimens studied so far. Other species of Borrelia including Borrelia garinii, Borrelia miyamotoi, and Borrelia hermsii have also been detected in skin specimens taken from MD patients. The optimal treatment for MD remains to be determined. Keywords: Morgellons disease, dermatitis, Lyme disease, Borrelia burgdorferi, spirochetes

  19. 75 FR 53320 - National Institute of Mental Health; Notice of Closed Meetings

    Science.gov (United States)

    2010-08-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Mental...: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person... of Mental Health, National Institutes of Health, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda...

  20. 75 FR 41212 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-07-15

    ..., Bethesda, MD 20892, 301-435- 1259, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... Health, 6701 Rockledge Drive, Room 5202, MSC 7850, Bethesda, MD 20892, (301) 435-0910, [email protected]csr.nih...

  1. 78 FR 69430 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-19

    ... Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892, 301-435- 0903, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by... Health, 6701 Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892,301-435- 0903, [email protected]csr.nih.gov...

  2. 78 FR 45252 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-07-26

    ... 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle... Health, 6701 Rockledge Drive, Room 3130, MSC 7850, Bethesda, MD 20892, 301-435-3009, [email protected]csr.nih.gov...

  3. 75 FR 13767 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-03-23

    ... Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by..., Bethesda, MD 20892, 301-435- 4514, [email protected]csr.nih.gov . This notice is being published less than 15 days...

  4. 78 FR 66754 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-06

    ..., Bethesda, MD 20892, 301-435- 0677, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... 7844, Bethesda, MD 20892, (301) 806-3323, [email protected]csr.nih.gov . Name of Committee: Center for...

  5. 76 FR 31966 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-06-02

    ..., Bethesda, MD 20892, 301-435- 1259, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... Health, 6701 Rockledge Drive, Room 4811, MSC 7850, Bethesda, MD 20892, 301-435-1203, [email protected]csr.nih.gov...

  6. 77 FR 27471 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Science.gov (United States)

    2012-05-10

    ..., 6701 Rockledge Drive, 9th Floor Conference Facility, Bethesda, MD 20892. Closed: May 30, 2012, 11:30 a... Health, 6701 Rockledge Drive, 9th Floor Conference Facility, Bethesda, MD 20892. Open: May 31, 2012, 8:00... Disorders Research Advisory Board. Date: May 30-31, 2012. Open: May 30, 2012, 8:00 a.m. to 11:30 a.m. Agenda...

  7. 77 FR 37425 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-21

    ...: St. Gregory Hotel, 2033 M Street NW., Washington, DC 20036. Contact Person: Mark P Rubert, Ph.D.... Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814... p.m. Agenda: To review and evaluate grant applications. Place: St Gregory Hotel, 2033 M Street...

  8. 75 FR 21005 - National Advisory Council on the National Health Service Corps; Notice of Meeting

    Science.gov (United States)

    2010-04-22

    ... (BCRS), discuss recruitment and marketing strategies for the NHSC, and address current workforce issues.... Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852, Phone...

  9. 77 FR 2073 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2012-01-13

    ... 2--Translational Clinical Integrated Review Group; Basic Mechanisms of Cancer Therapeutics Study... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Fouad A El-Zaatari, Ph.D...

  10. 78 FR 15020 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2013-03-08

    ... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: John J. Laffan, Ph.D..., and Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88...

  11. 78 FR 5191 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2013-01-24

    ... review and evaluate grant applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue.... to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: DoubleTree by Hilton Hotel... applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact...

  12. 2017 Global Explosive Ordnance Disposal (EOD) Symposium and Exhibition. Held in North Bethesda, MD on 8-9 August 2017.

    Science.gov (United States)

    2017-08-09

    45 AM Keynote Address: Technology Innovation to Counter Improvised Threats and DTRA Integration Update • LTG Michael Shields, USA, Director...10:00 AM Networking Break EOD Silent Auction Opens Salons A-E 10:00 AM - 10:30 AM JIDO Technology Outreach Session: JIDO Overview and Counter...SYMPOSIUM & EXHIBITION AUGUST 7-9, 2017 AGENDA 10:30 AM - 11:15 AM EODWF State of the Foundation and Warrior Panel: Personal Stories of Growth

  13. 77 FR 5259 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-02

    .... Place: Bethesda North Marriott & Conference Center, 5701 Marinelli Road, North Bethesda, MD 20852...:30 p.m. Agenda: To review and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali...

  14. 77 FR 12603 - National Institute of Mental Health; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-01

    ... Health; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as...: Doubletree Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: March 14, 2012, 8:30 a.m. to 12... meet with PIs Training Fellows and Staff Scientists. Place: Doubletree Hotel Bethesda, 8120 Wisconsin...

  15. Maintenance program developmentandImport /Export of Aircraft in USA

    OpenAIRE

    Takele, Teklu

    2009-01-01

    AbstractThis thesis discuss how United Parcel Service (UPS) develop its aircraft maintenanceprogram after import of McDonnell Douglas MD-11aircraft and the process of exporting newMD-11 aircraft from manufacturer in USA to European operator as passenger aircraft. It alsodiscusses the process of importing the same types of aircraft as freight carrier. The aircraftundergo, through different modifications at Singapore Technologies Aerospace (STA)conversion from passenger to freight carrier, a pr...

  16. Advancing the understanding of progression in multiple sclerosis: an interview with Shibeshih Belachew.

    Science.gov (United States)

    Belachew, Shibeshih

    2018-02-01

    Shibeshih Belachew speaks to Laura Dormer, Commissioning Editor: Dr Shibeshih Belachew, MD, PhD, is a Senior Medical Director for Multiple Sclerosis (MS) Disease Area in Global Product Development Medical Affairs at Roche (Basel, Switzerland). Prior to joining Roche in January 2016, he was Director of MS Franchise and Head of Medical Director's office for Biogen Region Europe and Canada. Previously at Biogen he also served as a Director in Global Neurology for the natalizumab program in Cambridge (MA, USA). Prior to joining industry, he was a Clinical Professor of Neurology at the University of Liège in Belgium. Shibeshih completed neurology postgraduate training at the University of Liège and has a PhD in Biomedical Science in the field of Developmental Neurobiology. Shibeshih has been a post-doctoral fellow in the Laboratory of Cellular and Synaptic Neurophysiology at the National Institutes of Health (Bethesda, MD, USA) and later at the Center for Neuroscience Research of Children's National Medical Center in Washington DC. He is a member of the Belgian Neurological Society.

  17. The discovery of 260Md and the decay properties of 258Fm, 258m,gMd and 259Md

    International Nuclear Information System (INIS)

    Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

    1986-01-01

    We have discovered a new neutron-rich isotope, 260 Md, from 18 O and 22 Ne bombardments of 254 Es. We observed a spontaneous-fission (SF) activity with a half-life of 32 days in electromagnetically separated fractions with mass number 260 from these bombardments and we measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at a total kinetic energy (TKE) of 234 MeV, similar to previous observations for heavy fermium isotopes. Surprisingly, we also observed a smaller symmetric component with a TKE of 195 MeV. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of 260 Md or from 260 Fm which would arise from electron-capture (EC) decay of 260 Md. We have eliminated the possible β - decay of 260 Md by measuring β - -SF time correlations for the decay of 260 Md and we plan to determine whether 260 Md decays by EC by measuring time correlations between fermium X-rays and SF events. We also measured various properties of the heavy fermium and mendelevium isotopes and obtained 1. more accurate cross-sections for the neutron-rich mendelevium isotopes which we use to predict the production rates of yet undiscovered nuclides, 2. improved half-life measurements for 258m,g Md and 259 Md, 3. confirmation of the EC decay of 258m Md by measurement of the fermium X-rays preceding the SF decay of 258 Fm and 4. very substantially improved mass and TKE distributions for the SF decay of 258 Fm and 259 Md. (orig.)

  18. The revised Bethesda guidelines: extent of utilization in a university hospital medical center with a cancer genetics program

    Directory of Open Access Journals (Sweden)

    Mukherjee Aparna

    2010-11-01

    Full Text Available Abstract Background In 1996, the National Cancer Institute hosted an international workshop to develop criteria to identify patients with colorectal cancer who should be offered microsatellite instability (MSI testing due to an increased risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC. These criteria were further modified in 2004 and became known as the revised Bethesda Guidelines. Our study aimed to retrospectively evaluate the percentage of patients diagnosed with HNPCC tumors in 2004 who met revised Bethesda criteria for MSI testing, who were referred for genetic counseling within our institution. Methods All HNPCC tumors diagnosed in 2004 were identified by accessing CoPath, an internal database. Both the Tumor Registry and patients' electronic medical records were accessed to collect all relevant family history information. The list of patients who met at least one of the revised Bethesda criteria, who were candidates for MSI testing, was then cross-referenced with the database of patients referred for genetic counseling within our institution. Results A total of 380 HNPCC-associated tumors were diagnosed at our institution during 2004 of which 41 (10.7% met at least one of the revised Bethesda criteria. Eight (19.5% of these patients were referred for cancer genetic counseling of which 2 (25% were seen by a genetics professional. Ultimately, only 4.9% of patients eligible for MSI testing in 2004 were seen for genetic counseling. Conclusion This retrospective study identified a number of barriers, both internal and external, which hindered the identification of individuals with HNPCC, thus limiting the ability to appropriately manage these high risk families.

  19. 78 FR 8156 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute... proposals. Place: Bethesda North Marriott Hotel & Conference Center, Montgomery County Conference Center... Institute, NIH, 6116 Executive Blvd., Suite 703, Room 7072, Bethesda, md 20892-8329, 301-594-1408, Stoicaa2...

  20. 78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... Stage Development of Emerging Technologies in Biospecimen Science. Date: February 20, 2013. Time: 12:00... Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Ellen K... p.m. Agenda: To review and evaluate grant applications. Place: Bethesda North Marriott Hotel...

  1. Md Naimuddin

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Md Naimuddin. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1255-1258 Poster Presentations. Model unspecific search for new physics in collision at s = 7 TeV · Shivali Malhotra Md Naimuddin Thomas Hebbeker Arnd Meyer ...

  2. 78 FR 57168 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-17

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... grant applications. Place: Washington Hilton Hotel, 1919 Connecticut Ave. NW., Washington, DC 20009... Hotel Bethesda, (Formerly Holiday Inn Select), 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  3. Apple fruit acidity is genetically diversified by natural variations in three hierarchical epistatic genes MdSAUR37, MdPP2CH and MdALMTII.

    Science.gov (United States)

    Jia, Dongjie; Shen, Fei; Wang, Yi; Wu, Ting; Xu, Xuefeng; Zhang, Xinzhong; Han, Zhenhai

    2018-05-11

    Many efforts have been made to map quantitative trait loci (QTLs) to facilitate practical marker-assisted selection (MAS) in plants. In the present study, we identified four genome-wide major QTLs responsible for apple fruit acidity by MapQTL and BSA-seq analyses using two independent pedigree-based populations. Candidate genes were screened in major QTL regions, and three functional gene markers, including a non-synonymous A/G single nucleotide polymorphism (SNP) in the coding region of MdPP2CH, a 36-bp insertion in the promoter of MdSAUR37, and a previously reported SNP in MdALMTII, were validated to influence the malate content of apple fruits. In addition, MdPP2CH inactivated three vacuolar H + -ATPases (MdVHA-A3, MdVHA-B2 and MdVHA-D2) and one aluminium-activated malate transporter (MdALMTII) via dephosphorylation and negatively influenced fruit malate accumulation. The dephosphotase activity of MdPP2CH was suppressed by MdSAUR37, which implied a higher hierarchy of genetic interaction. Therefore, the MdSAUR37/MdPP2CH/MdALMTII chain cascaded hierarchical epistatic genetic effects to precisely determine apple fruit malate content. An A/G SNP (-1010) on MdMYB44 promoter region from a major QTL (qtl08.1) was closely associated with fruit malate content. The predicted phenotype values (PPVs) were estimated using the tentative genotype values of the gene markers, and the PPVs were significantly correlated with the observed phenotype values. Our findings provide an insight into plant genome-based selection in apples and will aid in conducting research to understand the physiological fundamentals of quantitative genetics. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  4. Commuter Air Carrier Symposium (2nd) January 15-16, 1981 .

    Science.gov (United States)

    1981-01-16

    AJAN B1 UNCLASSIFIED FAA-ASF-300-81-b NL J , E EEEIEEEI mIhIhhEIhEEEI EEIhIhEIhEEIhE IIIIIIIIIIIIIu IIIEII~lElI Second ot Denrpotmn A Fodeol~(ntiorpom...Kathryn B. Creedy AVMARK, Inc. Commuter Air 1120 19th St., N.W. 4827 Rugby Ave. Washington, D.C. 20002 Bethesda, MD 20008 J. Keith Carter Albert J...Commuter Air Piper Aircraft Corp. 4823 Rugby Rd. 3000 Medulla Rd. Bethesda, MD 20014 Lakeland, Florida 33803 -Calvin Davison ’ Crowell & Moring 1100

  5. Injector MD Days 2017

    CERN Document Server

    Rumolo, G

    2017-01-01

    The Injector Machine Development (MD) days 2017 were held on 23-24 March, 2017, at CERN with thefollowing main goals:Give a chance to the MD users to present their results and show the relevant progress made in 2016 onseveral fronts.Provide the MD users and the Operation (OP) crews with a general overview on the outcome and theimpact of all ongoing MD activities.Identify the open questions and consequently define - with priorities - a list of machine studies in theinjectors for 2017 (covering the operational beams, LHC Injectors Upgrade, High Luminosity LHC,Physics Beyond Colliders, other projects).Create the opportunity to collect and document the highlights of the 2016 MDs and define the perspectivesfor 2017.Discuss how to make best use of the MD time, in particular let the main MD user express their wishesand see whether/how OP teams can contribute to their fulfilment.

  6. 77 FR 32651 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-01

    ... meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections...). Contact Person: Charles H Washabaugh, Ph.D., Scientific Review Officer, Scientific Review Branch, National... applications. Place: Bethesda Marriott, 5151 Pooks Hill Road, Bethesda, MD 20814. Contact Person: Charles N...

  7. Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Todd NW

    2013-03-01

    Full Text Available Nevins W Todd,1,2 Rachel G Scheraga,1,3 Jeffrey R Galvin,1,4 Aldo T Iacono,1 E James Britt,1 Irina G Luzina,1,2 Allen P Burke,5,* Sergei P Atamas1,2,* 1Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; 2Baltimore VA Medical Center, Baltimore, MD, USA; 3Critical Care Medicine Department, National Institutes of Health, Bethesda, MD, USA; 4Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, USA; 5Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA *These authors contributed equally to this work Background: Idiopathic pulmonary fibrosis (IPF is a fatal lung disease with no known effective therapy. It is often assumed, but has not been objectively evaluated, that pulmonary inflammation subsides as IPF progresses. The goal of this work was to assess changes in the degree of inflammatory cell infiltration, particularly lymphocytic infiltration, over the duration of illness in IPF. Methods: Sixteen patients with confirmed IPF were identified in patients whom surgical lung biopsy (SLB was performed in early disease, and in patients whom lung transplantation was subsequently performed in end stage disease. A numerical scoring system was used to histologically quantify the amount of fibrosis, honeycomb change, fibroblastic foci, and lymphocyte aggregates in each SLB and lung explant tissue sample. Analyses of quantitative scores were performed by comparing paired, matched samples of SLB to lung explant tissue. Results: Median time [1st, 3rd quartiles] from SLB to lung transplantation was 24 [15, 29] months. Histologic fibrosis and honeycomb change were more pronounced in the explant samples compared with SLB (P < 0.001 and P < 0.01, respectively, and most notably, higher numbers of lymphocyte aggregates were observed in the explant samples compared to SLB (P = 0.013. Immunohistochemical analyses revealed abundant CD3+ (T lymphocyte and CD20+ (B

  8. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

    Science.gov (United States)

    Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

    2017-07-11

    Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

  9. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

  10. 76 FR 27070 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-05-10

    ...: Cardiovascular Devices. Date: June 20, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant... Abuse Research Using Existing Epidemiology, Prevention, and Treatment Research Data. Date: June 20-21... applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, North Bethesda, MD...

  11. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2012-01-19

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Bita Nakhai, Ph.D.... to 3 p.m. Agenda: To review and evaluate grant applications. Place: DoubleTree by Hilton Hotel...

  12. 76 FR 17930 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-31

    ... Nanotechnology. Date: July 12-13, 2011. Time: 8 a.m. to 6 p.m. Agenda: To review and evaluate grant applications... review and evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Gerald G. Lovinger, PhD, Scientific Review Administrator...

  13. Identification of 253Md

    International Nuclear Information System (INIS)

    Kadkhodayan, B.; Czerwinski, K.R.; Kreek, S.A.; Hannink, N.J.; Gregorich, K.E.; Lee, D.M.; Nurmia, M.J.; Hoffman, D.C.; Hall, H.L.

    1992-01-01

    We have measured the half-life and production cross section of the new isotope 253 Md, produced via the 243 Am( 13 C,3n) reaction. Isolation of Md from other activities was accomplished using elution with ammonium α-hydroxyisobutyrate from a cation exchange resin column. Experiments were performed with different irradiation time intervals, but the chemical separation always began and ended at exactly the same length of time after the end of irradiation. All separations with the same irradation lengths were combined and analyzed for growth and decay of the 3.0-d 253 Fm daughter and 20.47-d 253 Es, granddaugther of 253 Md. The amount of 253 Es in each fraction depends on the length of each irradiation and the 253 Md half-life. An increase in the length of irradiation will cause a corresponding increase in the amount of the new isotope 253 Md and hence, in the amount of 253 Es produced, provided the length of irradiations are not very long compared to the half-life of 253 Md. In this way, the Md half-life was estimated to be about 6 minutes with a production cross section of the order of 50 nb. (orig.)

  14. Targeting Siah2 as Novel Therapy for Metastatic Prostate Cancer

    Science.gov (United States)

    2016-10-01

    Institutes of Health 900 Rockville Pike Bethesda, MD 20892 Phone : (240) 276-6280 15 E-mail: sarah.lee@nih.gov 1 R01 CA179170-02 (PI: Ronai, Z.) 09/30...Cammie La National Institutes of Health 9000 Rockville Pike Bethesda, MD 20892 Phone : (240) 276-6323 E-mail: cl311z@nih.gov 1 R01 CA172017-02...PI: Ronai, Z.) 07/01/13–04/30/16 1.2 calendar (10.0%) NIH/NCI ATF2 Oncogenic Addiction in Melanoma Goals: The major goal of this project is to

  15. 78 FR 9931 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-12

    ... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Abdelouahab Aitouche, Ph...). Contact Person: James J Li, Ph.D., Scientific Review Officer, Center for Scientific Review, National...: Chemistry, Biochemistry and Biophysics Date: March 6-7, 2013 Time: 8:30 a.m. to 5:00 p.m. Agenda: To review...

  16. 78 FR 70567 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Institutes of Health, 6701 Rockledge Drive, Room 3091, Bethesda, MD, 20892 which was published in the Federal Register on September 18, 2013, 78 FR 57399. The meeting will be held at the Bethesda Marriott Hotel, 5151...

  17. Ask a Scientist: What is Color Blindness?

    Medline Plus

    Full Text Available ... MSC 9300 Bethesda, MD 20892-9300 (Courier services use: Rockville, MD 20852) 301-451-2020 Research at NEI Office of the Scientific Director Office of the Clinical Director Laboratories, Sections and Units Division of Epidemiology and Clinical ...

  18. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  19. Patient Workload Profile: National Naval Medical Center (NNMC), Bethesda, MD.

    Science.gov (United States)

    1980-06-01

    AD-A09a 729 WESTEC SERVICES NC SAN DIEGOCA0S / PATIENT WORKLOAD PROFILE: NATIONAL NAVAL MEDICAL CENTER NNMC),- ETC(U) JUN 80 W T RASMUSSEN, H W...provides site workload data for the National Naval Medical Center (NNMC) within the following functional support areas: Patient Appointment...on managing medical and patient data, thereby offering the health care provider and administrator more powerful capabilities in dealing with and

  20. Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

    Science.gov (United States)

    Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

    2016-12-01

    Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  1. 76 FR 3642 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-20

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... evaluate grant applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD... North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person...

  2. Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

    Directory of Open Access Journals (Sweden)

    Isaacson BM

    2014-04-01

    Full Text Available Brad M Isaacson,1,2 Sujee Jeyapalina3,4 1Henry M Jackson Foundation for the Advancement of Military Medicine, 2The Center for Rehabilitation Sciences Research, Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, USA; 3Department of Orthopedics, 4Orthopedic Research Laboratory, University of Utah, Salt Lake City, UT, USA Abstract: Direct skeletal fixation, termed osseointegration, has expanded in the last century and includes use in total joint replacements, the edentulous mandible and maxilla, and percutaneous osseointegrated prosthetics. Although it is well known that titanium and bone have the ability to form a durable bone–implant interface, new applications have emerged in the field of orthopedics, which requires a more thorough assessment of the literature. This review aims to introduce the basic biological principles for attaining osseointegration and discusses the major factors for assuring successful cementless fixation. Keywords: osseointegration, bone, skeletal attachment, total joint replacements, dental implants, percutaneous

  3. 75 FR 47203 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes Equipped...

    Science.gov (United States)

    2010-08-05

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...

  4. Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

    Science.gov (United States)

    Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

    2017-01-01

    MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple ( Malus × domestica ). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1 , and MdPR10-2 . In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26 . In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

  5. Improving bethesda reporting in thyroid cytology: A team effort goes a long way and still miles to go…

    Directory of Open Access Journals (Sweden)

    Subramanian Kannan

    2017-01-01

    Full Text Available Context: Fine-needle aspiration cytology is the first step in evaluation of thyroid nodules. Although the Bethesda classification for reporting thyroid cytology has been purported that this uniformity in reporting cytology thereby facilitating clinical decision-making, there are also studies indicating that the reporting percentage and the rates of malignancy in each category vary considerably from center to center making the clinical decision more difficult. Aim and Materials and Methods: We looked at our retrospective cytology and histopathology data of thyroid nodules operated between 2012 and 2014 and then prospectively collected data during 2015–2016. In the prospective arm, for every thyroid nodule that was sampled, there was a discussion between the endocrinologist and the cytopathologist on the risk of thyroid cancer (based on the patient's history, examination findings, sonographic pattern, and the cytological appearance. Results: We noted that there was considerable improvement in reporting standards with the rates of nondiagnostic cytology dropping from 11% to 5%, an increased reporting of Bethesda Category 2 and 6 which are the definitive strata of benign and malignant nodules (38% to 41% in Category 2 and 7% to 11% in Category 6 with a high specificity (100%. There was a decline in numbers of Category 4 and 5 (13% to 9% in Category 4 and 12% to 3% in Category 5. The reporting prevalence of Category 3 increased from 19% to 27%. Conclusions: We conclude that a team approach between the clinician who performs the ultrasound and the reporting cytopathologist improves Bethesda reporting, its predictive value, and thus potentially avoiding unnecessary thyroidectomies in benign thyroid nodules and hemithyroidectomies in thyroid cancers.

  6. 75 FR 80744 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

    Science.gov (United States)

    2010-12-23

    ...-1203; Directorate Identifier 2010-NM-168-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87) and MD-88...

  7. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Autogenic Drainage Positive Expiratory Pressure High-Frequency Chest Wall Oscillation (the Vest) ... Cystic Fibrosis Foundation 4550 Montgomery Ave. Suite 1100 N Bethesda, MD ...

  8. Calling All Golfers | Poster

    Science.gov (United States)

    Teams are forming for the third annual R&W Club Frederick Golf Tournament on Sept. 14. Last year’s tournament hosted more than 40 players and raised nearly $1,000 for the NIH Children’s Inn, Bethesda, Md.  The tournament will be held at Maryland National Golf Club in Middletown, Md

  9. mdFoam+: Advanced molecular dynamics in OpenFOAM

    Science.gov (United States)

    Longshaw, S. M.; Borg, M. K.; Ramisetti, S. B.; Zhang, J.; Lockerby, D. A.; Emerson, D. R.; Reese, J. M.

    2018-03-01

    This paper introduces mdFoam+, which is an MPI parallelised molecular dynamics (MD) solver implemented entirely within the OpenFOAM software framework. It is open-source and released under the same GNU General Public License (GPL) as OpenFOAM. The source code is released as a publicly open software repository that includes detailed documentation and tutorial cases. Since mdFoam+ is designed entirely within the OpenFOAM C++ object-oriented framework, it inherits a number of key features. The code is designed for extensibility and flexibility, so it is aimed first and foremost as an MD research tool, in which new models and test cases can be developed and tested rapidly. Implementing mdFoam+ in OpenFOAM also enables easier development of hybrid methods that couple MD with continuum-based solvers. Setting up MD cases follows the standard OpenFOAM format, as mdFoam+ also relies upon the OpenFOAM dictionary-based directory structure. This ensures that useful pre- and post-processing capabilities provided by OpenFOAM remain available even though the fully Lagrangian nature of an MD simulation is not typical of most OpenFOAM applications. Results show that mdFoam+ compares well to another well-known MD code (e.g. LAMMPS) in terms of benchmark problems, although it also has additional functionality that does not exist in other open-source MD codes.

  10. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  11. [Implementation of cytology images classification--the Bethesda 2001 System--in a group of screened women from Podlaskie region--effect evaluation].

    Science.gov (United States)

    Zbroch, Tomasz; Knapp, Paweł Grzegorz; Knapp, Piotr Andrzej

    2007-09-01

    Increasing knowledge concerning carcinogenesis within cervical epithelium has forced us to make continues modifications of cytology classification of the cervical smears. Eventually, new descriptions of the submicroscopic cytomorphological abnormalities have enabled the implementation of Bethesda System which was meant to take place of the former Papanicolaou classification although temporarily both are sometimes used simultaneously. The aim of this study was to compare results of these two classification systems in the aspect of diagnostic accuracy verified by further tests of the diagnostic algorithm for the cervical lesion evaluation. The study was conducted in the group of women selected from general population, the criteria being the place of living and cervical cancer age risk group, in the consecutive periods of mass screening in Podlaski region. The performed diagnostic tests have been based on the commonly used algorithm, as well as identical laboratory and methodological conditions. Performed assessment revealed comparable diagnostic accuracy of both analyzing classifications, verified by histological examination, although with marked higher specificity for dysplastic lesions with decreased number of HSIL results and increased diagnosis of LSILs. Higher number of performed colposcopies and biopsies were an additional consequence of TBS classification. Results based on Bethesda System made it possible to find the sources and reasons of abnormalities with much greater precision, which enabled causing agent treatment. Two evaluated cytology classification systems, although not much different, depicted higher potential of TBS and better, more effective communication between cytology laboratory and gynecologist, making reasonable implementation of The Bethesda System in the daily cytology screening work.

  12. 77 FR 28886 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-05-16

    ... Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Stephen M... review and evaluate grant applications. Place: Hotel Monaco Alexandria, 480 King Street, Alexandria, VA...

  13. 78 FR 50426 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2013-08-19

    ... secrets or commercial property such as patentable material, and personal information concerning.... Place: NIH Building 60 (The Cloister), 1 Cloister Court (Center Drive and Convent Drive), Bethesda, MD...

  14. 78 FR 7438 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-01

    ... Rockledge Drive, Bethesda, MD 20892. Contact Person: Melinda Jenkins, Ph.D., Scientific Review Officer... Henry, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health...

  15. 78 FR 66022 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2013-11-04

    ... Panel; Small Business: Biological Chemistry, Biophysics and Drug Discovery. Date: November 4, 2013. Time... of Health, 6701 Rockledge Drive, Bethesda, MD 20892. Contact Person: Sergei Ruvinov, Ph.D...

  16. Food swamps and food deserts in Baltimore City, MD, USA: associations with dietary behaviours among urban adolescent girls.

    Science.gov (United States)

    Hager, Erin R; Cockerham, Alexandra; O'Reilly, Nicole; Harrington, Donna; Harding, James; Hurley, Kristen M; Black, Maureen M

    2017-10-01

    To determine whether living in a food swamp (≥4 corner stores within 0·40 km (0·25 miles) of home) or a food desert (generally, no supermarket or access to healthy foods) is associated with consumption of snacks/desserts or fruits/vegetables, and if neighbourhood-level socio-economic status (SES) confounds relationships. Cross-sectional. Assessments included diet (Youth/Adolescent FFQ, skewed dietary variables normalized) and measured height/weight (BMI-for-age percentiles/Z-scores calculated). A geographic information system geocoded home addresses and mapped food deserts/food swamps. Associations examined using multiple linear regression (MLR) models adjusting for age and BMI-for-age Z-score. Baltimore City, MD, USA. Early adolescent girls (6th/7th grade, n 634; mean age 12·1 years; 90·7 % African American; 52·4 % overweight/obese), recruited from twenty-two urban, low-income schools. Girls' consumption of fruit, vegetables and snacks/desserts: 1·2, 1·7 and 3·4 servings/d, respectively. Girls' food environment: 10·4 % food desert only, 19·1 % food swamp only, 16·1 % both food desert/swamp and 54·4 % neither food desert/swamp. Average median neighbourhood-level household income: $US 35 298. In MLR models, girls living in both food deserts/swamps consumed additional servings of snacks/desserts v. girls living in neither (β=0·13, P=0·029; 3·8 v. 3·2 servings/d). Specifically, girls living in food swamps consumed more snacks/desserts than girls who did not (β=0·16, P=0·003; 3·7 v. 3·1 servings/d), with no confounding effect of neighbourhood-level SES. No associations were identified with food deserts or consumption of fruits/vegetables. Early adolescent girls living in food swamps consumed more snacks/desserts than girls not living in food swamps. Dietary interventions should consider the built environment/food access when addressing adolescent dietary behaviours.

  17. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  18. 78 FR 11658 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-19

    ... Select), 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Robert Horowits, Ph.D., Scientific... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

  19. Time for Decisions: Visualizing the Future. Proceedings of the Annual NEAIR Conference (39th, Bethesda, Maryland, November 3-6, 2012)

    Science.gov (United States)

    Carson, Cristi, Ed.

    2012-01-01

    The NEAIR (North East Association for Institutional Research) 2012 Conference Proceedings is a compilation of papers presented at the Bethesda, Maryland conference. Papers in this document include: (1) Can a Marketing Campaign Increase Response Rates to Online Course Evaluations? (Kimberly Puhala); (2) Developing Community College Peer…

  20. 78 FR 58547 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-24

    [email protected] . Name of Committee: Oncology 2--Translational Clinical Integrated Review Group; Cancer... Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Fouad A El-Zaatari, Ph.D., Scientific Review Officer...

  1. 76 FR 80955 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

    Science.gov (United States)

    2011-12-27

    ... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, Vitamin D and Diabetes. Date: January 25... Democracy Boulevard, Bethesda, MD 20817. Contact Person: Michele L. Barnard, Ph.D., Scientific Review...

  2. 78 FR 59040 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2013-09-25

    ... Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Brian R. Pike, Ph.D., Scientific... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

  3. 76 FR 47218 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-08-04

    ..., Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lawrence Ka-Yun Ng, PhD, Scientific Review..., HHS) Dated: July 28, 2011. Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy...

  4. The opioid overdose epidemic: opportunities for pharmacists

    Directory of Open Access Journals (Sweden)

    Wu LT

    2017-07-01

    Full Text Available Li-Tzy Wu,1–4 Udi E Ghitza,5 Anne L Burns,6 Paolo Mannelli,1 1Department of Psychiatry and Behavioral Sciences, 2Department of Medicine, 3Duke Clinical Research Institute, Duke University School of Medicine, 4Center for Child and Family Policy, Sanford School of Public Policy, Duke University, Durham, NC, 5Center for Clinical Trials Network, National Institute on Drug Abuse, Bethesda, MD, 6American Pharmacists Association, Washington, DC, USA The USA is experiencing an opioid overdose epidemic. It has been driven largely by prescription opioids and intensified by a surge of illicit opioids (e.g., heroin and fentanyl.1,2 Drug-involved overdose, mainly opioids (e.g., prescription opioids and heroin, is a leading cause of accidental death in the USA. The opioid overdose epidemic has been escalating consistently for over a decade.2 Every day, an estimated 91 Americans die from opioid-related overdose.3 Opioid overdose appears to have disproportionally affected men, adults aged 25–64 years, and non-Hispanic whites.2

  5. Spontaneous fission of 259Md

    International Nuclear Information System (INIS)

    Hulet, E.K.; Wild, J.F.; Lougheed, R.W.; Baisden, P.A.; Landrum, J.H.; Dougan, R.J.; Mustafa, M.; Ghiorso, A.; Nitschke, J.M.

    1979-01-01

    The mass and kinetic energy distributions of fission fragments from the spontaneous fission of th newly discovered nuclide 259 Md were obtained. 259 Md was identified as the E. C. daughter of 259 No, and was found to decay entirely (> 95%) by spontaneous fission with a 95-min half-life. From the kinetic energies measured for 397 pairs of coincident fragments, a mass distribution was derived that is symmetric with sigma = 13 amu. 259 Md, together with 258 Fm and 259 Fm, form a select group of three nuclides whose mass division in spontaneous fission is highly symmetric. Unlike the total-kinetic-energy (TKE) distributions of 258 Fm and 259 Fm, which peak at approx. = to 240 MeV, this distribution for 259 Md is broad and is 50 MeV lower in energy. Analysis of the mass and energy distributions shows that events near mass symmetry also exhibit a broad TKE distribution, with one-third of the symmetric events having TKEs less than 200 MeV. The associated of low TKEs with symmetric mass division in the fission of very heavy actinides is anomalous and inconsistent with theories based upon the emergence of fragment shells near the scission point. Either three-body fragmentation or peculiar fragment shapes are assumed as the cause for the large consumption of Coulomb energy observed for a significant fraction of symmetric fissions in 259 Md. 6 figures

  6. Evolution of approaches to viral safety issues for biological products.

    Science.gov (United States)

    Lubiniecki, Anthony S

    2011-01-01

    CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Approaches to viral safety issues for biological products have evolved during the past 50+ years. The first cell culture products (viral vaccines) relied largely on the use of in vitro and in vivo virus screening assays that were based upon infectivity of adventitious viral agents. The use of Cohn fractionation and pasteurization by manufacturers of plasma derivatives introduced the concepts that purification and treatment with physical and chemical agents could greatly reduce the risk of viral contamination of human albumin and immunoglobulin products. But the limitations of such approaches became clear for thermolabile products that were removed early in fractionation such as antihemophilic factors, which transmitted hepatitis viruses and HIV-1 to some product recipients. These successes and limitations were taken into account by the early developers of recombinant DNA (rDNA)-derived cell culture products and by regulatory agencies, leading to the utilization of cloning technology to reduce/eliminate contamination due to human viruses and purification technologies to physically remove and inactivate adventitious and endogenous viruses, along with cell banking and cell bank characterization for adventitious and endogenous viruses, viral screening of biological raw materials, and testing of cell culture harvests, to ensure virus safety. Later development and incorporation of nanofiltration technology in the manufacturing process provided additional assurance of viral clearance for safety of biotechnology products. These measures have proven very effective at preventing iatrogenic infection of recipients of biotechnology products; however, viral contamination of production cell cultures has

  7. 77 FR 10539 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2012-02-22

    ... Research Special Emphasis Panel; RFA DE12-004 & 005 Functional Restoration of Salivary Glands. Date: March... Garden Inn, 7301 Waverly St., Bethesda, MD 20814. Contact Person: Marilyn Moore-Hoon, Ph.D., Scientific...

  8. Medline Plus

    Full Text Available ... made. ©2018 BroadcastMed About MedlinePlus Site ... Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on ...

  9. 78 FR 28233 - National Eye Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-05-14

    ..., National Eye Institute, Bethesda, MD 20892, (301) 451-6763. In the interest of security, NIH has instituted stringent procedures for entrance onto the NIH campus. All visitor vehicles, including taxicabs, hotel, and...

  10. Diabetes HealthSense: Resources for Living Well

    Medline Plus

    Full Text Available ... health worker Community organization Age Select one: Child Teen and young ... The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-2560, Telephone: 301.496.3583

  11. 76 FR 20359 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-04-12

    ..., Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Lawrence E Boerboom, PhD, Chief, CVRS IRG...: April 4, 2011. Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2011...

  12. 76 FR 54238 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2011-08-31

    ...: Language, Communication, Cognition and Perception. Date: September 13-14, 2011. Time: 10 a.m. to 8 p.m... Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Jane A Doussard-Roosevelt, PhD, Scientific...

  13. About MedlinePlus

    Science.gov (United States)

    ... Want to learn more? Guide to Healthy Web Surfing Sign Up for Email Updates Training Materials ... Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page ...

  14. 78 FR 10622 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-14

    ..., Bethesda, MD 20892, 301-496-7628, [email protected] . In the interest of security, NIH has instituted stringent procedures for entrance onto the NIH campus. All visitor vehicles, including taxicabs, hotel, and airport...

  15. 77 FR 9675 - Center for Scientific Review: Notice of Closed Meetings

    Science.gov (United States)

    2012-02-17

    ... Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Lawrence E Boerboom, Ph.D., Chief, CVRS IRG, Center...-93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: February 10, 2012. Jennifer S...

  16. MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

    Science.gov (United States)

    An, Xiu-Hong; Tian, Yi; Chen, Ke-Qin; Liu, Xiao-Juan; Liu, Dan-Dan; Xie, Xing-Bin; Cheng, Cun-Gang; Cong, Pei-Hua; Hao, Yu-Jin

    2015-04-01

    Anthocyanin and proanthocyanidin (PA) are important secondary metabolites and beneficial to human health. Their biosynthesis is induced by jasmonate (JA) treatment and regulated by MYB transcription factors (TFs). However, which and how MYB TFs regulate this process is largely unknown in apple. In this study, MdMYB9 and MdMYB11 which were induced by methyl jasmonate (MeJA) were functionally characterized. Overexpression of MdMYB9 or MdMYB11 promoted not only anthocyanin but also PA accumulation in apple calluses, and the accumulation was further enhanced by MeJA. Subsequently, yeast two-hybrid, pull-down and bimolecular fluorescence complementation assays showed that both MYB proteins interact with MdbHLH3. Moreover, Jasmonate ZIM-domain (MdJAZ) proteins interact with MdbHLH3. Furthermore, chromatin immunoprecipitation-quantitative PCR and yeast one-hybrid assays demonstrated that both MdMYB9 and MdMYB11 bind to the promoters of ANS, ANR and LAR, whereas MdbHLH3 is recruited to the promoters of MdMYB9 and MdMYB11 and regulates their transcription. In addition, transient expression assays indicated that overexpression of MdJAZ2 inhibits the recruitment of MdbHLH3 to the promoters of MdMYB9 and MdMYB11. Our findings provide new insight into the mechanism of how MeJA regulates anthocyanin and PA accumulation in apple. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. View Full Treatment Information Definition The muscular dystrophies (MD) are a group of more than 30 ...

  18. Life After Traumatic Injury: How the Body Responds

    Science.gov (United States)

    ... individual. This result was surprising because the existing theory was that people who heal quickly from a ... National Institute of General Medical Sciences 45 Center Drive MSC 6200 Bethesda, MD 20892-6200 Tel: 301- ...

  19. 76 FR 71580 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-11-18

    ... Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be... Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Charles Joyce, Ph.D., Scientific...

  20. 76 FR 62082 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-06

    ... 2201, Bethesda, MD 20892, (301) 496-7628, [email protected] . In the interest of security, NIH has..., hotel, and airport shuttles will be inspected before being allowed on campus. Visitors will be asked to...

  1. Medline Plus

    Full Text Available ... for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  2. Medline Plus

    Full Text Available ... for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated ...

  3. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  4. High-Resolution Forest Carbon Monitoring and Modeling: Continued Prototype Development and Deployment Across The Tri-state Area (MD, PA, DE), USA

    Science.gov (United States)

    Hurtt, G. C.; Birdsey, R.; Campbell, E.; Dolan, K. A.; Dubayah, R.; Escobar, V. M.; Finley, A. O.; Flanagan, S.; Huang, W.; Johnson, K.; Lister, A.; ONeil-Dunne, J.; Sepulveda Carlo, E.; Zhao, M.

    2017-12-01

    Local, national and international programs have increasing need for precise and accurate estimates of forest carbon and structure to support greenhouse gas reduction plans, climate initiatives, and other international climate treaty frameworks. In 2010 Congress directed NASA to initiate research towards the development of Carbon Monitoring Systems (CMS). In response, our team has worked to develop a robust, replicable framework to produce maps of high-resolution carbon stocks and future carbon sequestration potential. High-resolution (30m) maps of carbon stocks and uncertainty were produced by linking national 1m-resolution imagery and existing wall-to-wall airborne lidar to spatially explicit in-situ field observations such as the USFS Forest Inventory and Analysis (FIA) network. These same data, characterizing forest extent and vertical structure, were used to drive a prognostic ecosystem model to predict carbon fluxes and carbon sequestration potential at unprecedented spatial resolution and scale (90m), more than 100,000 times the spatial resolution of standard global models. Through project development, the domain of this research has expanded from two counties in MD (2,181 km2), to the entire state (32,133 km2), to the tri-state region of MD, PA, and DE (157,868 km2), covering forests in four major USDA ecological providences (Eastern Broadleaf, Northeastern Mixed, Outer Coastal Plain, and Central Appalachian). Across the region, we estimate 694 Tg C (14 DE, 113 MD, 567 PA) in above ground biomass, and estimate a carbon sequestration potential more than twice that amount. Empirical biomass products enhance existing approaches though high resolution accounting for trees outside traditional forest maps. Modeling products move beyond traditional MRV, and map future afforestation and reforestation potential for carbon at local actionable spatial scales. These products are relevant to multiple stakeholder needs in the region as discussed through the Tri

  5. Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7 th2010"

    Directory of Open Access Journals (Sweden)

    Maio Michele

    2011-03-01

    Full Text Available Abstract Progress in understanding the molecular basis of melanoma has made possible the identification of molecular targets with important implications in clinical practice. In fact, new therapeutic approaches are emerging from basic science and it will be important to implement their rapid translation into clinical practice by active clinical investigation. The first meeting of Melanoma Research: a bridge Naples-USA, organized by Paolo A. Ascierto (INT, Naples, Italy and Francesco Marincola (NIH, Bethesda, USA took place in Naples, on 6-7 December 2010. This international congress gathered more than 30 international and Italian faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive discussion across Institutions belonging to Government, Academy and Pharmaceutical Industry, in order to stimulate new approaches in basic, translational and clinical research. Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies.

  6. A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin

    Directory of Open Access Journals (Sweden)

    Gianfranco Favi

    2013-02-01

    Full Text Available A series of substituted ethyl 1-[(tert-butoxycarbonylamino]-2-methyl-5- (1-methyl-1H-indol-3-yl-4-[(1-methyl-1H-indol-3-ylcarbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98% by one-pot reactions between β-dicarbonyl compounds 12a–e and 1,2-diaza-1,3-diene (DD 13. Derivatives 10a,c–e, deazaanalogues of the bis-indole alkaloid topsentin, screened by the National Cancer Institute (Bethesda, MD, USA in the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity, with the exception of compound 9e, which showed moderate activity against the HOP-92 cell line of the non small cell lung cancer sub-panel and the SNB-75 cell line of the CNS sub-panel.

  7. Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations

    DEFF Research Database (Denmark)

    Farooqui, Mohammed Z H; Valdez, Janet; Martyr, Sabrina

    2015-01-01

    BACKGROUND: Patients with chronic lymphocytic leukaemia (CLL) with TP53 aberrations respond poorly to first-line chemoimmunotherapy, resulting in early relapse and short survival. We investigated the safety and activity of ibrutinib in previously untreated and relapsed or refractory CLL with TP53...... aberrations. METHODS: In this investigator-initiated, single-arm phase 2 study, we enrolled eligible adult patients with active CLL with TP53 aberrations at the National Institutes of Health Clinical Center (Bethesda, MD, USA). Patients received 28-day cycles of ibrutinib 420 mg orally once daily until...... in one (2%) patient. INTERPRETATION: The activity and safety profile of single-agent ibrutinib in CLL with TP53 aberrations is encouraging and supports its consideration as a novel treatment option for patients with this high-risk disease in both first-line and second-line settings. FUNDING: Intramural...

  8. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

  9. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    Meel, J.A. van; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

  10. Major Depression Among Adults

    Science.gov (United States)

    ... Depressive Episode Among Adolescents Data Sources Share Major Depression Definitions Major depression is one of the most ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  11. Antidepressant Medications for Children and Adolescents: Information for Parents and Caregivers

    Science.gov (United States)

    ... What Should You Do for a Child With Depression? A child or adolescent with MDD should be ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  12. Seasonal Affective Disorder

    Science.gov (United States)

    ... than any non-seasonal depressions. Symptoms of Major Depression Feeling depressed most of the day, nearly every ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  13. Eosinophilic Esophagitis

    Science.gov (United States)

    ... the esophagus, which can lead to difficulty swallowing (dysphagia) or food getting stuck in the esophagus. Reflux ... Irritable Bowel Syndrome Obesity ©2018 American College of Gastroenterology 6400 Goldsboro Rd Ste 200 Bethesda, MD 20817 ( ...

  14. 75 FR 62547 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-10-12

    .... Place: Double Tree Hotel, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: November 16, 2010, 9 a.m. to... will be asked to show one form of identification (for example, a government-issued photo ID, driver's...

  15. Urge incontinence

    Science.gov (United States)

    ... and are not able to store much urine. Augmentation cystoplasty is the surgery most often performed for ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  16. Surgical wound care

    Science.gov (United States)

    ... replacement Anti-reflux surgery Bladder exstrophy repair Breast augmentation surgery Breast lump removal Bunion removal Carotid artery ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  17. Chin augmentation - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100009.htm Chin augmentation - series—Normal anatomy To use the sharing features ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  18. Breast augmentation - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100205.htm Breast augmentation - series—Normal anatomy To use the sharing features ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  19. Obsessive Compulsive Disorder among Adults

    Science.gov (United States)

    ... Adults Data Sources Share Obsessive-Compulsive Disorder (OCD) Definition Obsessive-compulsive disorder (OCD) is often a long- ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  20. Panic Disorder among Adults

    Science.gov (United States)

    ... Disorder Among Adolescents Data Sources Share Panic Disorder Definition Panic Disorder is an anxiety disorder characterized by ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  1. 77 FR 58851 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting

    Science.gov (United States)

    2012-09-24

    ..., Room 4A30, Bethesda, MD 20892, 301-496- 3006, [email protected] . In the interest of security, NIH... taxicabs, hotel, and airport shuttles will be inspected before being allowed on campus. Visitors will be...

  2. Phenylketonuria

    Science.gov (United States)

    ... plays a role in the body's production of melanin. The pigment is responsible for skin and hair ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  3. Giant congenital nevus

    Science.gov (United States)

    ... womb. Melanocytes are the skin cells that produce melanin, which gives skin its color. A nevus has ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  4. Paleness

    Science.gov (United States)

    ... flow in the skin rather than deposit of melanin in the skin. Paleness can be caused by: ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  5. Food Safety: MedlinePlus Health Topic

    Science.gov (United States)

    ... Food and Drug Administration) Also in Spanish Animal Cloning and Food Safety (Food and Drug Administration) Chemicals ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated ...

  6. Mutagenic Potential of 4-Nitrophenyl Monochloromethyl (Phenyl) Phosphinate Using the Drosophila melanogaster Sex-Linked Recessive Lethal Test.

    Science.gov (United States)

    1983-08-01

    chromosomes were tested from the concurrent negative control. This sample size was adequate for analysis using the Fisher’s Exact test ( personal communication...study may be regarded as adequate ( personal communication - Dr. Gildengorin, Statistician, Information Sciences, Letterman Army Institute of Research...Health Sciences 0917 Arlington Road Bethesda MD 20014 CM nd Commander US Army Euvaoomens Hygine Agency US Army Research Institute Abardan Proving Ground MD

  7. Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

    Science.gov (United States)

    Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

    2018-07-01

    Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Pulling a patient up in bed

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 12. Review Date 11/15/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  9. Small bowel resection - discharge

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 26. Read More Colon cancer Crohn ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  10. Getting yourself healthy before surgery

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Review Date 9/17/2016 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  11. Central venous catheter - flushing

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Read More Bone marrow transplant ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  12. Turning patients over in bed

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 12. Review Date 11/15/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  13. Nasogastric feeding tube

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 16. Ziegler TR. Malnutrition, nutritional assessment, ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  14. Peripherally inserted central catheter - dressing change

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Review Date 11/20/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  15. Peripherally inserted central catheter - flushing

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29.6. Read More Bone marrow ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  16. Central venous catheter - dressing change

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 29. Read More Bone marrow transplant ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  17. Peripherally inserted central catheter - insertion

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Review Date 11/20/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  18. Wet to dry dressing changes

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 25. Patient Instructions Cosmetic breast surgery - ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  19. Large bowel resection - discharge

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Read More Colon cancer Colostomy ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  20. Total colectomy or proctocolectomy - discharge

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Read More Colon cancer Ileostomy ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  1. The day of your surgery - adult

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Review Date 9/17/2016 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  2. Bathing a patient in bed

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 8. Timby BK. Assisting with basic ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  3. Moving a patient from bed to a wheelchair

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 12. Timby BK. Assisting with basic ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  4. Aging changes in the senses

    Science.gov (United States)

    ... A delicious meal or pleasant aroma can improve social interaction and enjoyment of life. Smell and taste also ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  5. Gender dysphoria

    Science.gov (United States)

    ... opposite sex Have depression or anxiety Withdraw from social interaction Exams and Tests The feeling of being in ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  6. 75 FR 6043 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-05

    ... Tree Hotel, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: March 16, 2010, 9 p.m. to 2:30 p.m. Agenda... show one form of identification (for example, a government-issued photo ID, driver's license, or...

  7. Personality Disorders

    Science.gov (United States)

    ... Disorders in Adults Data Sources Share Personality Disorders Definitions Personality disorders represent “an enduring pattern of inner ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  8. To Your Health: NLM Update—MedlinePlus

    Science.gov (United States)

    ... illustrate health care May 7 2018 Transcript Genetic architecture of mental disorders April 30 2018 Transcript Why ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  9. Older Adults and Mental Health

    Science.gov (United States)

    ... counselor at a crisis center in your area 24/7. Disaster Distress Helpline : People affected by natural or ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  10. The 2017 Bethesda System for Reporting Thyroid Cytopathology.

    Science.gov (United States)

    Cibas, Edmund S; Ali, Syed Z

    2017-11-01

    The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established a standardized, category-based reporting system for thyroid fine-needle aspiration (FNA) specimens. The 2017 revision reaffirms that every thyroid FNA report should begin with one of six diagnostic categories, the names of which remain unchanged since they were first introduced: (i) nondiagnostic or unsatisfactory; (ii) benign; (iii) atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS); (iv) follicular neoplasm or suspicious for a follicular neoplasm; (v) suspicious for malignancy; and (vi) malignant. There is a choice of two different names for some of the categories. A laboratory should choose the one it prefers and use it exclusively for that category. Synonymous terms (e.g., AUS and FLUS) should not be used to denote two distinct interpretations. Each category has an implied cancer risk that ranges from 0% to 3% for the "benign" category to virtually 100% for the "malignant" category, and, in the 2017 revision, the malignancy risks have been updated based on new (post 2010) data. As a function of their risk associations, each category is linked to updated, evidence-based clinical management recommendations. The recent reclassification of some thyroid neoplasms as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has implications for the risk of malignancy, and this is accounted for with regard to diagnostic criteria and optional notes. Such notes can be useful in helping guide surgical management.

  11. A Comparison of the American Society of Cataract and Refractive Surgery post-myopic LASIK/PRK Intraocular Lens (IOL calculator and the Ocular MD IOL calculator

    Directory of Open Access Journals (Sweden)

    Hsu M

    2011-09-01

    Full Text Available David L DeMill1, Majid Moshirfar1, Marcus C Neuffer1, Maylon Hsu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USABackground: To compare the average values of the American Society of Cataract and Refractive Surgery (ASCRS and Ocular MD intraocular lens (IOL calculators to assess their accuracy in predicting IOL power in patients with prior laser-in-situ keratomileusis (LASIK or photorefractive keratectomy.Methods: In this retrospective study, data from 21 eyes with previous LASIK or photorefractive keratectomy for myopia and subsequent cataract surgery was used in an IOL calculator comparison. The predicted IOL powers of the Ocular MD SRK/T, Ocular MD Haigis, and ASCRS averages were compared. The Ocular MD average (composed of an average of Ocular MD SRK/T and Ocular MD Haigis and the all calculator average (composed of an average of Ocular MD SRK/T, Ocular MD Haigis, and ASCRS were also compared. Primary outcome measures were mean arithmetic and absolute IOL prediction error, variance in mean arithmetic IOL prediction error, and the percentage of eyes within ±0.50 and ±1.00 D.Results: The Ocular MD SRK/T and Ocular MD Haigis averages produced mean arithmetic IOL prediction errors of 0.57 and –0.61 diopters (D, respectively, which were significantly larger than errors from the ASCRS, Ocular MD, and all calculator averages (0.11, –0.02, and 0.02 D, respectively, all P < 0.05. There was no statistically significant difference between the methods in absolute IOL prediction error, variance, or the percentage of eyes with outcomes within ±0.50 and ±1.00 D.Conclusion: The ASCRS average was more accurate in predicting IOL power than the Ocular MD SRK/T and Ocular MD Haigis averages alone. Our methods using combinations of these averages which, when compared with the individual averages, showed a trend of decreased mean arithmetic IOL

  12. MD2190: Q" Stabilization during injection

    CERN Document Server

    Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2018-01-01

    This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

  13. 76 FR 23828 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-28

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis..., National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD....279, Drug Abuse and [[Page 23829

  14. Logistics | Division of Cancer Prevention

    Science.gov (United States)

    Date and Time Registration will begin at 8:30 am on Friday, September 20th. The meeting will begin promptly at 9:00 am. Location NIH Campus Natcher Conference Center Building 45 45 Center Drive Bethesda, MD |

  15. 42 CFR 52.8 - Other HHS regulations and policies that apply.

    Science.gov (United States)

    2010-10-01

    ... (March 28, 1994)—NIH Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research... on Women's Health, NIH, Room 201, Building 1, MSC 0161, BETHESDA, MD 20892-0161 (301-402-1770; not a...

  16. MedlinePlus FAQ: Disease or Condition Information

    Science.gov (United States)

    ... on the Health Topics button on the MedlinePlus homepage. You can also find the Health Topics button ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  17. Despite the Shutdown, Rescheduled NIH Research Festival Brings Science to the Forefront | Poster

    Science.gov (United States)

    By Andrea Frydl, Contributing Writer Although it was delayed by almost a month because of the federal shutdown, the NIH Research Festival still took place at the NIH Clinical Center in Bethesda, Md., and attendance was high.

  18. Development of the Young Brain

    Medline Plus

    Full Text Available ... a few surprises. &#160; Watch on YouTube. Transcript Announcer: Parents and caregivers have always been ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  19. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... they got help. &#160; Watch on YouTube. Transcript RODOLFO : I didn't want to face ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  20. Capillary sample

    Science.gov (United States)

    ... Phlebotomy Handbook . 9th ed. Upper Saddle River, NJ: Pearson; 2015:chap 11. Vajpayee N, Graham SS, Bem S. Basic ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  1. How Loud Is Too Loud?

    Medline Plus

    Full Text Available ... Your Hearing (infographic) Noise-Induced Hearing Loss Tinnitus Communication Methods & Devices for People With Hearing Loss American ... Into Health ® National Institute on Deafness and Other Communication Disorders 31 Center Drive, MSC 2320, Bethesda, MD ...

  2. Development of the Young Brain

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    Full Text Available ... When they get stuck in traffic. How they manage their time and their emotions. And this is ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  3. Symptoms and Treatment of Depression

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    Full Text Available ... Trials Outreach Outreach Home Stakeholder Engagement Outreach Partnership Program Alliance for Research Progress Coalition for Research Progress ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  4. Development of the Young Brain

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    Full Text Available ... Trials Outreach Outreach Home Stakeholder Engagement Outreach Partnership Program Alliance for Research Progress Coalition for Research Progress ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  5. Medline Plus

    Full Text Available ... Coral Springs, Coral Springs, FL, 3/31/2014) Digestive System Bile Duct Cancer Diagnosing & Treating Digestive Tract ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated ...

  6. 45 CFR 170.299 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Architecture (CDA) Release 2—Continuity of Care Document (CCD), April 01, 2007, IBR approved for § 170.205. (4... § 170.207. (2) [Reserved] (f) U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894...

  7. Development of the Young Brain

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    Full Text Available ... designed to learn through example. Dr. Giedd: This learning by example is very powerful and that parents ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  8. Symptoms and Treatment of Depression

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    Full Text Available ... Application Process Managing Grants Clinical Research Training Small Business Research Labs at NIMH Labs at NIMH Home ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  9. Development of the Young Brain

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    Full Text Available ... Application Process Managing Grants Clinical Research Training Small Business Research Labs at NIMH Labs at NIMH Home ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  10. Symptoms and Treatment of Depression

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    Full Text Available ... NIMHpress@nih.gov Press Resources Mental Health Information Summaries of Scientific Meetings Information about NIMH RePORTER : Research ... Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD 20892- ...

  11. Development of the Young Brain

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    Full Text Available ... NIMHpress@nih.gov Press Resources Mental Health Information Summaries of Scientific Meetings Information about NIMH RePORTER : Research ... Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD 20892- ...

  12. The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple.

    Science.gov (United States)

    Zhou, Li-Jie; Li, Yuan-Yuan; Zhang, Rui-Fen; Zhang, Chun-Ling; Xie, Xing-Bin; Zhao, Cheng; Hao, Yu-Jin

    2017-10-01

    MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its post-translational regulation. Here, a small ubiquitin-like modifier E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability. Moreover, the transcription level of MdSIZ1 gene was remarkably induced by low temperature and phosphorus deficiency, and MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions. Our findings reveal an important role for a small ubiquitin-like modifier modification of MYB transcription factors in regulation of anthocyanin biosynthesis in plants. © 2017 John Wiley & Sons Ltd.

  13. Cognition in the Brain: Investigations Using Positron Emission Tomography

    Science.gov (United States)

    1992-07-16

    0029 DDIRESS (City. State and ZIP Code) 10. SOURCE Of FUNDING NOS. _____________ .dg. 410 PROGRAM PROJECT TASKC WORK .,%r illing Air Force Base, DC...Bethesda, MD 20892 20. Daniel Bubb, M.D. Department of Neurolinguistics Montreal Neurological Institute 15. Sung-cheng tHuang, Ph.D. 3801 University...Chief of Pediatric Neu- rology Service Director, Center for Morphomet- 24. Terry Allard, Ph.D. ric Analysis Cognitive Science Programs Kennedy 9 Office

  14. Development of the Young Brain

    Medline Plus

    Full Text Available ... Information about NIMH RePORTER : Research Portfolio Online Reporting Tool Expenditures and Results Recommendations for Reporting on Suicide ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  15. MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-01-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

  16. The Teen Brain: 6 Things to Know

    Science.gov (United States)

    ... ePub Order a free hardcopy En Español Teen Depression Study: Understanding Depression in Teenagers Join a Research Study: Enrolling nationally ... Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH ...

  17. Eosinophilic Esophagitis in Pediatric and Adolescent Patients

    Science.gov (United States)

    ... the feeling of food getting stuck (known as dysphagia), especially with solid meals. Dysphagia can lead to food impaction, where food suddenly ... Irritable Bowel Syndrome Obesity ©2018 American College of Gastroenterology 6400 Goldsboro Rd Ste 200 Bethesda, MD 20817 ( ...

  18. 75 FR 45647 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-08-03

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, Conflicted... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817...

  19. Medline Plus

    Full Text Available ... 2014) These webcasts are provided to the National Library of Medicine by BroadcastMed . We welcome your comments . ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  20. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH Widget Subscribe to NIMH Email Updates Type email address... Privacy Notice Policies FOIA Accessibility Topic Finder Publicaciones en ...

  1. Development of the Young Brain

    Medline Plus

    Full Text Available ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS Feed NIMH Widget Subscribe to NIMH Email Updates Type email address... Privacy Notice Policies FOIA Accessibility Topic Finder Publicaciones en ...

  2. 75 FR 52764 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-08-27

    ... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict..., Bethesda, MD 20892. (301) 435- 0684. [email protected] . Name of Committee: Integrative, Functional and....gov . Name of Committee: Integrative, Functional and Cognitive Neuroscience Integrated Review Group...

  3. 78 FR 64222 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-10-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... clearly unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research... Review, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, 301...

  4. 78 FR 21382 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... applications. Place: National Human Genome Research Institute, Suite 4076, 5635 Fisher's Lane, Bethesda, MD..., National Human Genome Research Institute, National Institutes of Health, 5635 Fishers Lane, Suite 4075...

  5. 75 FR 53317 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-08-31

    ...-435-1119. [email protected] . Name of Committee: Oncology 1--Basic Translational Integrated..., Bethesda, MD 20892. (301) 451- 4467. [email protected] . Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group, Synthetic and Biological Chemistry A Study Section. Date...

  6. Your Baby's Hearing and Communicative Development Checklist

    Science.gov (United States)

    ... YES NO Has one or two words (“Hi,” “dog,” “Dada,” or “Mama”) by first birthday YES NO ... information, contact us at: NIDCD Information Clearinghouse 1 Communication Avenue Bethesda, MD 20892-3456 Toll-free voice: ( ...

  7. Speech and Language Developmental Milestones

    Science.gov (United States)

    ... YES NO Has one or two words (“Hi,” “dog,” “Dada,” or “Mama”) by first birthday YES NO ... information, contact us at: NIDCD Information Clearinghouse 1 Communication Avenue Bethesda, MD 20892-3456 Toll-free voice: ( ...

  8. 78 FR 26378 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 5184, MSC 7844, Bethesda, MD 20892 301-435- 1242, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Clinical, Integrative and Molecular...

  9. 77 FR 52338 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-08-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review..., Bethesda, MD 20892, (301) 408-9512, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Clinical, Integrative and Molecular Gastroenterology Study...

  10. Theoretical Thermal Evaluation of Energy Recovery Incinerators

    Science.gov (United States)

    1985-12-01

    Army Logistics Mgt Center, Fort Lee , VA DTIC Alexandria, VA DTNSRDC Code 4111 (R. Gierich), Bethesda MD; Code 4120, Annapolis, MD; Code 522 (Library...Washington. DC: Code (I6H4. Washington. DC NAVSECGRUACT PWO (Code .’^O.’^). Winter Harbor. IVIE ; PWO (Code 4(1). Edzell. Scotland; PWO. Adak AK...NEW YORK Fort Schuyler. NY (Longobardi) TEXAS A&M UNIVERSITY W.B. Ledbetter College Station. TX UNIVERSITY OF CALIFORNIA Energy Engineer. Davis CA

  11. The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

    Science.gov (United States)

    Dash, Madhumita; Malladi, Anish

    2012-06-25

    Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

  12. 76 FR 63314 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2011-10-12

    ... for Scientific Review Special Emphasis Panel, PAR-10-235: Climate Change and Health. Date: November 8... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892...

  13. 76 FR 31621 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-06-01

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, Scholarly Works... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone...

  14. 76 FR 17660 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-30

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; Conflicteds. Date... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine...: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817 (Telephone Conference...

  15. 75 FR 6042 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-05

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel. Date: April 22... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone Conference Call...

  16. 76 FR 2913 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-18

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel R01. Date... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine...: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817. (Telephone Conference...

  17. 78 FR 24221 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-24

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; Scholarly Works... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817...

  18. 77 FR 24968 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2012-04-26

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; Scholarly Works... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817. Contact Person...

  19. 76 FR 5591 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-01

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, Loan Repayment... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone...

  20. 76 FR 22716 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-04-22

    ..., Bethesda, MD 20892, 301-402- 5671, [email protected] . Name of Committee: Brain Disorders and Clinical... Disorders and Clinical Neuroscience, Center for Scientific Review, National Institutes of Health, 6701... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Kidney, Urology Continues...

  1. 78 FR 75929 - National Institute of Dental & Craniofacial Research; Notice of Closed Meetings

    Science.gov (United States)

    2013-12-13

    ... Craniofacial Research Special Emphasis Panel; Review of NIDCR Institutional Career Development Award K12... review and evaluate grant applications. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD 20892. Contact Person: Victor Henriquez, Ph.D., Scientific Review Officer...

  2. 75 FR 29357 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2010-05-25

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special NCMHD Health Disparities Research on Minority and Underserved... Health and Health Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892. (301) 594-8696...

  3. the case of the insect resistant maize for Africa

    African Journals Online (AJOL)

    GREGORY

    2011-06-01

    Jun 1, 2011 ... 2PATH Malaria Vaccine Initiative, 7500 Old Georgetown Rd., Suite 1200. Bethesda, MD .... demonstrations held against the production of genetically modified crops. ... Some headlines, however, have indicated government support for ... requirements and preparing for stakeholders' meetings, which were ...

  4. 77 FR 3478 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-01-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: Sheraton Delfina Santa Monica Hotel, 530 West Pico Boulevard, Santa... Review, National Institutes of Health, 6701 Rockledge Drive, Room 4132, MSC 7802, Bethesda, MD 20892...

  5. 75 FR 54893 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-09-09

    ... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Selected Topics... . Name of Committee: Immunology Integrated Review Group, Innate Immunity and Inflammation Study Section... 5132, MSC 7843, Bethesda, MD 20892. 301-594-6830. [email protected] . Name of Committee: Immunology...

  6. 75 FR 51828 - National Human Genome Research Institute; Notice of Meetings

    Science.gov (United States)

    2010-08-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... personal privacy. Name of Committee: National Advisory Council for Human Genome Research. Date: February 7... Research, National Human Genome Research Institute, 5635 Fishers Lane, Suite 4076, MSC 9305, Bethesda, MD...

  7. 78 FR 56902 - National Institute on Deafness and Other Communication Disorders; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-16

    ... Deafness and Other Communication Disorders; Notice of Closed Meetings Pursuant to section 10(d) of the... Deafness and Other Communication Disorders Special Emphasis Panel; Vestibular Clinical Trial Review. Date..., Bethesda, MD 20892, (301) 496-8683, [email protected] . Name of Committee: Communication Disorders...

  8. 75 FR 26972 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-05-13

    ... Committee: Oncology 1-Basic Translational Integrated Review Group, Tumor Cell Biology Study Section. Date..., Bethesda, MD 20892, 301-435-1783, [email protected] . Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group, Synthetic and Biological Chemistry A Study Section. Date: June...

  9. 77 FR 54580 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 3108, MSC 7808, Bethesda, MD 20892, (301) 435- 3562, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Kidney Molecular Biology and Genitourinary Organ...

  10. Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

    Science.gov (United States)

    Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

    2015-10-01

    Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  11. Chronostratigraphic Analysis of Geomorphic Features within the Former Sinepuxent Inlet: A Wave-Dominated Tidal Inlet along Assateague Island, MD, USA

    Science.gov (United States)

    Seminack, C.; McBride, R.; Petruny, L. M.

    2017-12-01

    The former Sinepuxent Inlet, located along the mixed-energy, wave-dominated Assateague Island, MD-VA, USA, contains some of the most robust recurved-spit ridges along the span of the barrier island. In addition, this former tidal inlet exhibits a poorly developed flood-tidal delta containing at least two sets of curvilinear ridges known as "washarounds". Historical maps and nautical charts indicate that the former Sinepuxent Inlet was open from 1755 to 1832. However, previous studies conducted at the former Sinepuxent Inlet hypothesized that the site was exposed to episodic breaching events because of the extensive width of the former inlet throat, constrained by the northern and southern recurved-spit ridges. A total of 16 sediment cores, 10 optically stimulated luminescence (OSL) samples, and three 14C samples (mixed benthic foraminifera and eastern mud snail [Ilyanassa obsolete]) were collected from the former Sinepuxent Inlet to place morphostratigraphic units into a chronological context. Six OSL samples were collected from the northern and southern recurved-spit ridges at mean sea level (MSL) to constrain genesis ages. Southern recurved-spit ages varied more than their northern counterparts, ranging from 1640 to 1990 AD. The northern recurved-spit ridges varied in age from 1770 to 1900 AD. Two OSL samples collected from flood-tidal delta ridges yielded ages from 1680 to 2000 AD. In addition, two 14C samples collected at 128 and 101 cm below MSL within the inlet throat yielded ages between 1720 and post-1950 AD. Ultimately, these dates overlap with the inlet activity phase as indicated in historical documents. Conversely, two OSL samples (155 and 201 cm below MSL) and one 14C sample (134 cm below MSL) collected from the inlet throat returned ages between 760 and 1465 AD. The contrast in ages between the older inlet throat and subaerial ridge samples supports the hypothesis that the former Sinepuxent Inlet was reactivated numerous times. Thus, the three age

  12. 78 FR 77475 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2013-12-23

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel Conflicts R01R21... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817...

  13. 76 FR 77242 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-12-12

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, Conflict R01/K99... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone...

  14. 78 FR 55265 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2013-09-10

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; Conflicts R01/K22... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817 (Telephone...

  15. 76 FR 9031 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-16

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel R25. Date: March... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817 (Telephone Conference Call...

  16. 77 FR 72365 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2012-12-05

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; Conflict R01/K99... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817...

  17. 77 FR 17490 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-26

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, Conflict R01/K99... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine.... Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone...

  18. 76 FR 2128 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-12

    ... Alcohol Abuse and Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Alcoholism Initial Review Group. Epidemiology, Prevention and Behavior Research Review... Alcoholism, Extramural Project Review Branch, 5635 Fishers Lane, Room 2085, Bethesda, MD 20892. 301-451-2067...

  19. 76 FR 63311 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2011-10-12

    ... Panel PAR-10-018: Accelerating the Pace of Drug Abuse Research Using Existing Epidemiology, Prevention... Special Emphasis Panel; Small Business: Cardiovascular Devices. Date: November 7, 2011. Time: 8 a.m. to 5.... Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference...

  20. 78 FR 63996 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2013-10-25

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Quantification of Drugs of Abuse and Related Substances in Biological Specimens (7788). Date: November 7, 2013..., National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD...

  1. 78 FR 42528 - National Center for Complementary & Alternative Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2013-07-16

    ... Complementary & Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Center for Complementary & Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892..., Research and Training in Complementary and Alternative Medicine, National Institutes of Health, HHS) Dated...

  2. 76 FR 18566 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-04

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel, NIMHD Conference Grant Application (R13) Review. Date... Health and Health Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 451-9536...

  3. 76 FR 63310 - National Center On Minority and Health Disparities Notice of Closed Meetings

    Science.gov (United States)

    2011-10-12

    ... and Health Disparities Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel; NIMHD Health Disparities Research (R01). Date: November... Disparities, National Institutes of Health, 6707 Democracy Blvd., MSC. 5465, Suite 800, Bethesda, MD 20892...

  4. 76 FR 21386 - National Institute on Aging

    Science.gov (United States)

    2011-04-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging... personal privacy. Name of Committee: National Institute on Aging Special Emphasis Panel; Organelle Lifespan.... Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  5. Clinical Investigation Program. Annual Progress Report. Volume 1

    Science.gov (United States)

    1994-01-20

    Components Surgical Day, Bethesda, MD, in April 1993. 2. Planned for FY-94 The Department of Clinical Investigation hopes to maintain the essence of the...sclerosing cholangitis after choledochojejun- ostomy : radiographic and biochemical improvement with antibiotic therapN. Am J Gastroenterol 1993;88:1635

  6. 77 FR 48506 - CPSC Safety Academy

    Science.gov (United States)

    2012-08-14

    ... Education, Global Outreach, & Small Business Ombudsman, 4330 East West Highway, Bethesda, MD 20814... box lunch will be provided at noon during the presentation on ``Compliance 101-The Basics.'' If you... individual's viewpoint or ability to represent certain interests (e.g., such as large manufacturers, small...

  7. Health Information in Multiple Languages

    Science.gov (United States)

    ... gov/languages/languages.html Health Information in Multiple Languages To use the sharing features on this page, please enable JavaScript. Use these ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 4 June 2018

  8. 75 FR 56552 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Meeting

    Science.gov (United States)

    2010-09-16

    ... meeting will be open to the public as indicated below, with attendance limited to space available... confidential trade secrets or commercial property such as patentable material, and personal information... Boulevard, Bethesda, MD 20892-5452, [email protected] . (Catalogue of Federal Domestic Assistance Program Nos...

  9. 77 FR 50140 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-08-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome..., Human Genome Research, National Institutes of Health, HHS) Dated: August 13, 2012. Anna Snouffer, Deputy..., Bethesda, MD 20892. Contact Person: Camilla E. Day, Ph.D., Scientific Review Officer, CIDR, National Human...

  10. 78 FR 66368 - National Institute of Mental Health; Notice of Workshop

    Science.gov (United States)

    2013-11-05

    ... live webcast and conference call. Name of Committee: Interagency Autism Coordinating Committee (IACC... 1, Conference Room--Wilson Hall, Bethesda, MD 20982. Conference Call Access: Phone number: 888-603..., November 12, 2013. The comments should include the name, address, telephone number and when applicable, the...

  11. Felicity Conditions for Human Skill Acquisition: Validating an AI (Artificial Intelligence)-Based Theory.

    Science.gov (United States)

    1983-11-01

    B1 /SHOW2 1/BORROW 2/BORROW 1/SHOW X/OVRWRT W/OVRWRT Figure 2-12...34,,** ’% ".."’ ’ ° ’ . . . . " " *, . . " " . " ". .". , . • " . " . ., ’ -". ,""" ’" - . , ’ ’. " FETcHi PATTERNS 229 V,., *AC1:AC LC:A C1 :COL A1 :BLK C2:COL A2:BLK T1DIG T B1 T2:DIGIT...Glen Bryan ERIC Facility-Acquisitions . Dr. Edward C. Weiss 6208 Poe Road 4833 Rugby Avenue National Science Foundation Bethesda, MD 20817 Bethesda.

  12. 75 FR 80511 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2010-12-22

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Development of Alternate Drug Delivery Dosage Forms for Drug Abuse Studies. Date: January 7, 2011..., National Institute on Drug Abuse, NIH, DHHS, Room 213, MSC 8401, 6101 Executive Boulevard, Bethesda, MD...

  13. 76 FR 64356 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

    Science.gov (United States)

    2011-10-18

    ... Drug Abuse (NIDA), HHS. ACTION: 30-Day notice of submission of information collection approval from the... Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD 20892-9557, or call non- toll-free number... stratification and clustering), the precision requirements or power calculations that justify the proposed sample...

  14. Proceedings of the American Towing Tank Conference (21st) Held in Washington, DC. on 5-7th August 1986,

    Science.gov (United States)

    1987-08-01

    therefore, ice in- wi, and therefore its rise time, ti, are gestion Dy the propeller(s). An analytico- of the ice specific gravity, , numerical study...Bethesda, MD [’.S.A. FERNANDES, A.C., Instituto de Pesqoisas Technologicas, Cidade Universitaria , Sao Paulo, BRAZIL FIREMAN, H., Naval Sea System

  15. 75 FR 65363 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2010-10-22

    ... Sciences Special Emphasis Panel; Review of Minority Biomedical Research Neuro Grant Applications. Date... General Medical Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... General Medical Sciences, National Institutes of Health, Natcher Building, Room 3AN18J, Bethesda, MD 20892...

  16. 75 FR 54157 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-03

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel; G08. Date... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20892-7968, 301-496-4253, [email protected

  17. 76 FR 49779 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2011-08-11

    ... personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, R01/R13/R21... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817...

  18. 78 FR 60885 - Proposed Collection; 60-Day Notice Request: Application Process for Clinical Research Training...

    Science.gov (United States)

    2013-10-02

    ... Notice Request: Application Process for Clinical Research Training and Medical Education at the Clinical... Research Training and Medical Education, NIH Clinical Center, 10 Center Drive, MSC 1158, Bethesda, MD 20892... Process for Clinical Research Training and Medical Education at the Clinical Center and its Impact on...

  19. 75 FR 69090 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

    Science.gov (United States)

    2010-11-10

    ... Alcohol Abuse and Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Alcoholism; Initial Review Group; Biomedical Research Review Subcommittee. Date: March 15-16, 2011... Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2019, Bethesda, MD 20892, 301-443-2861, marmillotp...

  20. 76 FR 69746 - National Institute On Alcohol Abuse And Alcoholism; Notice of Closed Meeting

    Science.gov (United States)

    2011-11-09

    ... Alcohol Abuse And Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Alcoholism Initial Review Group, Biomedical Research Review Subcommittee. Date: March 13, 2012... Abuse And Alcoholism, 5635 Fishers Lane, Rm 2019, Bethesda, MD 20892, (301) 443-2861, [email protected

  1. Healthy Blood Pressure "It's worth the effort!" | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... Grants Information Office of the National Institutes of Health, in Bethesda, Md., exercises up to 90 minutes at least four times a week. This includes 30 minutes of cardiovascular work on a treadmill, 15 minutes of stationary biking, 15 minutes on the elliptical machine, and 20 ...

  2. 75 FR 36429 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2010-06-25

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel, Medications..., National Institute on Drug Abuse, NIH, DHHS, Room 220, MSC 8401, 6101 Executive Blvd., Bethesda, MD 20892. 301-451-3086. [email protected] . Name of Committee: National Institute on Drug Abuse Special...

  3. 75 FR 13136 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-18

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis... Institute on Drug Abuse, NIH. DHHS, Room 220, MSC 8401, 6101 Executive Boulevard, Bethesda, MD 20892- 8401... Assistance Program Nos. 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health...

  4. 77 FR 54919 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-06

    ... invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel... Drug Abuse, NIH, Room 4228, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, (301) 451-3086, [email protected] . Name of Committee: National Institute on Drug Abuse Special Emphasis Panel...

  5. 76 FR 81954 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-12-29

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel Confirming Compliance with Experimental Pharmacotherapy Treatment of Drug Abuse (2227) Date: January 17, 2012. Time: 9 a..., National Institute on Drug Abuse, NIH, DHHS, Room 4234, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892...

  6. 78 FR 33853 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2013-06-05

    ... invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel... Affairs, National Institute on Drug Abuse, NIH, Room 4228, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, (301) 451-3086, [email protected] . Name of Committee: National Institute on Drug Abuse...

  7. 75 FR 57970 - National Center for Complementary & Alternative Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-23

    ... Complementary & Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Complementary and Alternative Medicine Special Emphasis Panel, Centers of Excellence for Research on CAM (CERC... Complementary, & Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892, 301-594-3456...

  8. 75 FR 13137 - National Center For Complementary and Alternative Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-18

    ... Complementary and Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... Complementary and Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892, (301) 451-6570... Training in Complementary and Alternative Medicine, National Institutes of Health, HHS) Dated: March 10...

  9. 76 FR 55078 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2011-09-06

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel, ZMD1 RN (02) NIMHD Comprehensive Center of Excellence... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

  10. 75 FR 42100 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2010-07-20

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel, NCMHD Social Determinants of Health (R01) Panel. Date... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 594-8696, [email protected

  11. 49 CFR 171.7 - Reference material.

    Science.gov (United States)

    2010-10-01

    .../publications.com; AAR Manual of Standards and Recommended Practices, Section C—Part III, Specifications for... Edition, March 1996 172.102. American Pyrotechnics Association (APA), P.O. Box 30438, Bethesda, MD 20824, (301) 907-8181, www.americanpyro.com: APA Standard 87-1, Standard for Construction and Approval for...

  12. 76 FR 54240 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

    Science.gov (United States)

    2011-08-31

    ...: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program, DEA/NIAID/NIH/DHHS, Room 3256... Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program... Drive, Bethesda, MD 20817 (Telephone Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific...

  13. 78 FR 59040 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC..., National Institutes of Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775...

  14. 77 FR 2276 - Teleconference and Public Meeting of the Chronic Hazard Advisory Panel on Phthalates and...

    Science.gov (United States)

    2012-01-17

    ... levels of children's, pregnant women's, and others' exposure to phthalates, based upon a reasonable... 2010, and in March, July, and November 2011, at the CPSC's offices in Bethesda, MD, and by... on children's health of all phthalates and phthalate alternatives, as used in children's toys and...

  15. Estimation of the Operating Characteristics When the Test Information of the Old Test Is Not Constant. II. Simple Sum Procedure of the Conditional P.D.F. Approach/Normal Approach Method Using Three Subtests of the Old Test, Number 2

    Science.gov (United States)

    1981-07-01

    discrimination parameter and b isg x g the item response difficulty parameter which satisfies (2.3) - b b1 b1 ...Acquisitions School of Education 4333 Rugby Avenue University of Massechusetts Bethesda, MD 20014 Amherst, MA 01002 1V -127- Non Govt Non Govt 1 Dr. Chester

  16. 78 FR 24762 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-26

    ..., Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, Ph.D., Director, Division of Extramural Activities... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental & Craniofacial Research; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act...

  17. 75 FR 13562 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-22

    ..., Room 117, Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, PhD, Director, Division of... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental & Craniofacial Research; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act...

  18. 77 FR 14816 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-13

    ... & Craniofacial Research; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act...: National Institutes of Health, Building 30, 30 Center Drive, 117, Bethesda, MD 20892 Contact Person: Alicia J. Dombroski, Ph.D., Director, Division of Extramural Activities, Natl Inst of Dental and...

  19. 76 FR 66077 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-25

    ... Center Drive, 117, Bethesda, MD 20892 Contact Person: Alicia J. Dombroski, PhD, Director, Division of... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental & Craniofacial Research; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act...

  20. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  1. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

    2012-01-01

    textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

  2. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    Science.gov (United States)

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  3. Swiss national MD-PhD-program: an outcome analysis.

    Science.gov (United States)

    Kuehnle, Katrin; Winkler, David T; Meier-Abt, Peter J

    2009-09-19

    This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years. One hundred and twenty six former and current students in the Swiss national MD-PhD program were surveyed via a Web-based questionnaire in September 2007. Twenty-four questions assessed information regarding participant demographics, information on the PhD thesis and publication activity, current positions and research activity, as well as participant's opinions, attitudes and career goals. Eighty questionnaires were received from 126 MD-PhD students and graduates (63.5% response rate). The responders consisted of present students (36%), former graduates (56%), and dropouts (8%). The percentage of women in the program was 23%, and the average duration of the program was 4.2 +/- 1.4 years. Research interests were predominantly in the fields of neuroscience, immunology, molecular biology and cancer research. A considerable portion of the MD-PhD graduates had an excellent publication record stemming from their PhD research work, and 89% were planning to continue a research-orientated career. Over 50% of those MD-PhD graduates completing their thesis before 2002 had already reached an assistant or full professor position at the time of the survey. Nearly all participants considered the MD-PhD training helpful to their career and high quality standards were assigned to the acquired practical and intellectual skills. However, criticism was expressed concerning the general mentoring and the career related mentoring. Moreover, general mentoring and career related mentoring were significantly less well perceived in research groups employing more than seven PhD students at the same time. The MD-PhD students and graduates surveyed were satisfied with their education and most of them continued a research-orientated career. Regarding the overall positive evaluation, this study supports the view that MD-PhD graduates are well qualified for a successful career in

  4. MD-11 PCA - Research flight team photo

    Science.gov (United States)

    1995-01-01

    On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.

  5. 77 FR 43344 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

    Science.gov (United States)

    2012-07-24

    ... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, NIH, 6100 Executive Boulevard, Room 5B01, Bethesda, MD... constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child...

  6. 77 FR 5031 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2012-02-01

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Committee: National Institute of Child Health and Human Development Initial Review Group; Developmental... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01-G, Bethesda, MD 20892...

  7. 75 FR 49500 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2010-08-13

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Pediatrics Subcommittee. Date: October... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  8. 76 FR 61719 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2011-10-05

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group, Developmental Biology Subcommittee... Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01-G, Bethesda, MD 20892, 301-435...

  9. 75 FR 16151 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting

    Science.gov (United States)

    2010-03-31

    ... National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Child Health and Human Development, NIH, 6100 Executive Blvd., Room 3A01, Bethesda, MD 20892, (301) 451... the meeting. Name of Committee: National Children's Study Advisory Committee. Date: April 27, 2010...

  10. 78 FR 6122 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2013-01-29

    ... invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel... on Drug Abuse, NIH, DHHS, Room 4245, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, 301-451-4530, [email protected] . Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; NIDA...

  11. 75 FR 25277 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2010-05-07

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel, NIDA B/START... Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 220, MSC 8401, 6101 Executive Blvd., Bethesda, MD, 301-402-6626, [email protected] . Name of Committee: National Institute on Drug Abuse Special...

  12. 76 FR 43334 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2011-07-20

    ... Institute of Child Health and Human Development Special Emphasis Panel, Children in Rural Poverty. Date... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  13. 77 FR 22795 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

    Science.gov (United States)

    2012-04-17

    ... Alcohol Abuse and Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Alcoholism Initial Review Group Biomedical Research Review Subcommittee. Date: June 12, 2012. Time... Abuse and Alcoholism, 5635 Fishers Lane, RM 2019, Bethesda, MD 20892, 301-443-2861, [email protected

  14. 78 FR 46358 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-07-31

    ..., (Telephone Conference Call). Contact Person: Careen K Tang-Toth, Ph.D., Scientific Review Officer, Center for... Emphasis Panel; Member Conflict: Cognition and Perception. Date: August 28-29, 2013. Time: 8:00 a.m. to 6... Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Mark Lindner, Ph.D., Scientific...

  15. 76 FR 24892 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting

    Science.gov (United States)

    2011-05-03

    ... meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections..., (Telephone Conference Call). Contact Person: Charles N. Rafferty, PhD, Chief, Scientific Review Branch... Democracy Boulevard, Suite 800, Bethesda, MD 20817, 301-594-5019, charles[email protected] . (Catalogue of...

  16. 78 FR 9933 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-12

    ... meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections... 20892, (Virtual Meeting). Contact Person: Charles N. Rafferty, Ph.D., Chief, Scientific Review Branch..., National Institutes of Health, Bethesda, MD 20817, 301-594-5019, charles[email protected] . (Catalogue of...

  17. 76 FR 72955 - Proposed Collection; Comment Request: “Ethical Dilemmas in Surgery and Utilization of Hospital...

    Science.gov (United States)

    2011-11-28

    ... Bioethics, the Clinical Center, the National Institutes of Health (NIH) will publish periodic summaries of.... The results of this study can be used by medical professionals, hospitals, and bioethicists in several... Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892-1156, Telephone: (301...

  18. 78 FR 57166 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-17

    ... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse... Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4245, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, 301-451-4530, [email protected] . Name of Committee: National Institute on Drug Abuse...

  19. 77 FR 52752 - National Institute on Drug Abuse; Notice of Meeting

    Science.gov (United States)

    2012-08-30

    ... U.S.C. App.), notice is hereby given of a meeting of the National Advisory Council on Drug Abuse..., legislative and program developments in the drug abuse field. Place: National Institutes of Health... Drug Abuse, NIH, DHHS, Room 4243, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892-89550, (301...

  20. 78 FR 69858 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-21

    ... invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel..., [email protected] . Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Seek... on Drug Abuse, NIH, DHHS, 6001 Executive Blvd., Room 4245, MSC 9550, Bethesda, MD 20892-9550, 301-451...

  1. 77 FR 72366 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-12-05

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; NIH Pathway... limitations imposed by the review and funding cycle. Name of Committee: National Institute on Drug Abuse... on Drug Abuse, NIH, DHHS, 6001 Executive Blvd., Room 4238, MSC 9550, Bethesda, MD 20892-9550, 301-402...

  2. 77 FR 33472 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-06

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis... Institute on Drug Abuse, NIH, DHHS, Room 4245, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, 301-451-4530, [email protected] . Name of Committee: National Institute on Drug Abuse Special Emphasis Panel...

  3. 77 FR 47654 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2012-08-09

    ... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse... Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892- 9550, (301) 435-1439, lf33c.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse...

  4. 75 FR 6042 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-05

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis... Institute on Drug Abuse, NIH, DHHS, Room 220, MSC 8401, 6101 Executive Blvd., Bethesda, MD 20892-8401, 301... Assistance Program Nos. 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health...

  5. 76 FR 51381 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2011-08-18

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis... Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4238, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892-9550, 301-402-6626, [email protected] . Name of Committee: National Institute on Drug Abuse...

  6. 75 FR 34462 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

    Science.gov (United States)

    2010-06-17

    ... Institute of Child Health and Human Development Special Emphasis Panel; Adolescent Medicine Trials Network... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d..., National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd. Room 5b01, Bethesda, MD...

  7. 76 FR 11500 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-02

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel; R01 grant review (03). Date: March 7, 2011. Time: 8 a.m... Health Disparities, National Institutes of Health, 6707 Democracy Boulevard, Suite 800, Bethesda, MD...

  8. 76 FR 57068 - National Center on Minority and Health Disparities Notice of Closed Meeting

    Science.gov (United States)

    2011-09-15

    ... and Health Disparities Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel; ZMD1 RN 01 NIMHD Exploratory Centers of Excellence (P20... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

  9. 78 FR 10621 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-14

    ... Minority Health and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... and Health Disparities Special Emphasis Panel; NIMHD Conference Grant Review (R13). Date: March 15... Health Disparities, 6707 Democracy Blvd., Suite 800, Bethesda, MD 20892, (301) 594-7784, [email protected

  10. 78 FR 13364 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-27

    ... Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Fouad A El-Zaatari, Ph.D... Etiology of Gastro- Intestinal Cancer. Date: March 21, 2013. Time: 12:00 p.m. to 2:00 p.m. Agenda: To... Research Integrated Review Group; AIDS-associated Opportunistic Infections and Cancer Study Section. Date...

  11. 76 FR 23826 - National Institute of Mental Health; Notice of Closed Meetings

    Science.gov (United States)

    2011-04-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Mental....m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW... Blvd., Room 6154, MSC 9606, Bethesda, MD 20892-9606, 301-443-7861, ds[email protected] . Name of...

  12. 75 FR 43491 - Sunshine Act Meetings

    Science.gov (United States)

    2010-07-26

    ....-10:30 a.m., Wednesday July 21, 2010. Changes to Meeting: Meeting postponed. For a recorded message containing the latest agenda information, call (301) 504-7948. FOR FURTHER INFORMATION CONTACT: Contact..., Bethesda, MD 20814 (301) 504-7923. Dated: July 21, 2010. . Todd A. Stevenson, Secretary. [FR Doc. 2010...

  13. 76 FR 55929 - CENTER FOR SCIENTIFIC REVIEW; Notice of Closed Meetings

    Science.gov (United States)

    2011-09-09

    ... personal privacy. Name of Committee: Oncology 2--Translational Clinical Integrated Review Group; Basic... Panel Synthetic and Biological Chemistry B. Date: October 4, 2011. Time: 11 a.m. to 12 p.m. Agenda: To... 7806, Bethesda, MD 20892, 301-435- 1728, [email protected] . Name of Committee: Biological Chemistry...

  14. 75 FR 13561 - National Institute of Dental & Craniofacial Research; Notice of Meeting

    Science.gov (United States)

    2010-03-22

    ... Floor, 31 Center Drive, Conference Room 10, Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, PhD... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental & Craniofacial Research; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as...

  15. 75 FR 82033 - National Institute of Dental and Craniofacial Research; Notice of Meeting

    Science.gov (United States)

    2010-12-29

    ... and Craniofacial Research; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory... 31C, 31 Center Drive, 6th Floor, Conference Room 10, Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, PhD, Director, Division of Extramural Activities, Natl. Inst. of Dental and Craniofacial Research...

  16. 76 FR 51995 - National Institute of Dental & Craniofacial Research; Notice of Meeting

    Science.gov (United States)

    2011-08-19

    ... & Craniofacial Research; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as... 31 C, 31 Center Drive, 6th Floor, Conference Room 10, Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, PhD, Director, Division of Extramural Activities, National Institute of Dental and Craniofacial...

  17. 77 FR 49820 - National Institute of Dental & Craniofacial Research; Notice of Meeting

    Science.gov (United States)

    2012-08-17

    ... Center Drive, 6th Floor, 10, Bethesda, MD 20892. Contact Person: Alicia J. Dombroski, Ph.D., Director... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental & Craniofacial Research; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as...

  18. ORTHOIMAGERY, TALBOT COUNTY, MD USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Digital orthographic imagery datasets contain georeferenced images of the Earth's surface, collected by a sensor in which object displacement has been removed for...

  19. 76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Science.gov (United States)

    2011-02-02

    ... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to.... The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke City MD, has a vertical clearance in...

  20. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

  1. 76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2011-04-11

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Thomas E. Mitchell, M.D....100(b) and 0.104, I hereby order that the Order to Show Cause issued to Thomas E. Mitchell, M.D., be...

  2. 77 FR 37421 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2012-06-21

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; PMTCT. Date: July 17-18, 2012. Time... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5b01, Bethesda, MD 20892...

  3. 75 FR 36429 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

    Science.gov (United States)

    2010-06-25

    ... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group Obstetrics and Maternal-Fetal Biology... Institute of Child, Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  4. 75 FR 36100 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

    Science.gov (United States)

    2010-06-24

    ... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Panel; Geisha. Date: July 13... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  5. 75 FR 25278 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2010-05-07

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; N44DA-10-5542... Institute on Drug Abuse, NIH, 6101 Executive Blvd., Room 220, MSC 8401, Bethesda, MD 20852, 301-435-1432, [email protected] . (Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and...

  6. 77 FR 65728 - Notice of Sunshine Act Meetings

    Science.gov (United States)

    2012-10-30

    ....nrc.gov. Thursday, November 29, 2012 2:30 p.m. Briefing on Security issues (Closed Ex-1) Week of... Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2). Week of November 12...

  7. 75 FR 62894 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-10-13

    ..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). Week of November 1, 2010... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting), (Contact: Michael Fuller, 301-415-0520). This meeting will be...

  8. 75 FR 61227 - Sunshine Act: Notice of Meeting

    Science.gov (United States)

    2010-10-04

    ... on Security Issues (Closed--Ex. 1). Week of November 1, 2010--Tentative Tuesday, November 2, 2010 9..., 2010 1:30 p.m.--NRC All Employees Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m.--Briefing on Medical Issues (Public...

  9. 77 FR 63847 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-17

    ... Emphasis Panel; PAR-10-235: Climate Change and Health. Date: November 8, 2012. Time: 11:30 a.m. to 6:30 p.m... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Virtual Meeting...

  10. Back Pain - Multiple Languages

    Science.gov (United States)

    ... List of All Topics All Back Pain - Multiple Languages To use the sharing features on this page, please enable JavaScript. Arabic (العربية) ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 31 May 2018

  11. Anemia - Multiple Languages

    Science.gov (United States)

    ... XYZ List of All Topics All Anemia - Multiple Languages To use the sharing features on this page, please enable JavaScript. Arabic (العربية) ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 30 April 2018

  12. Allergy - Multiple Languages

    Science.gov (United States)

    ... XYZ List of All Topics All Allergy - Multiple Languages To use the sharing features on this page, please enable JavaScript. Arabic (العربية) ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 23 May 2018

  13. Alcohol - Multiple Languages

    Science.gov (United States)

    ... XYZ List of All Topics All Alcohol - Multiple Languages To use the sharing features on this page, please enable JavaScript. Arabic (العربية) ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 16 April 2018

  14. HIV Among People Aged 50 and Over

    Science.gov (United States)

    ... 2012;102(8):1516-26. National Institute on Aging. HIV, AIDS, and older people . Bethesda, MD: National Institutes of Health; 2016. Accessed September 14, 2017. Lindau ST, Schumm LP, Laumann EO, Levinson W, O’Muircheartaigh CA, Waite LJ. A study of sexuality and health among older adults in the United ...

  15. 78 FR 19496 - Submission for OMB Review; 30-day Comment Request; The National Cancer Institute (NCI...

    Science.gov (United States)

    2013-04-01

    ... smoking cessation intervention designed for young adult smokers ages 18 to 29. The SmokefreeTXT program is... examine how exposure to the SmokefreeTXT intervention affects participants' success at quitting smoking..., Bethesda, MD 20892-7337 or call non-toll-free number 301-435-7610 or Email your request, including your...

  16. 78 FR 52206 - Center For Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-22

    ...: Biophysics, Biochemistry and Chemistry. Date: September 18-19, 2013. Time: 8:00 a.m. to 3:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: John L Bowers, Ph.D., Scientific Review Officer..., Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701...

  17. 77 FR 9672 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-17

    ...: Chemistry, Biochemistry, Biophysics, and Bioengineering. Date: March 9-14, 2012. Time: 11 a.m. to 5 p.m... Drive, Bethesda, MD 20892. Contact Person: Alexander Gubin, Ph.D., Scientific Review Officer, Center for... Santa Monica Hotel, 530 West Pico Boulevard, Santa Monica, CA 90405. Contact Person: Jose H Guerrier, Ph...

  18. 78 FR 36789 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-06-19

    .... Contact Person: Aruna K Behera, Ph.D., Scientific Review Officer, Center for Scientific Review, National...: Biochemistry & Macromolecular Biophysics. Date: July 15-17, 2013. Time: 8:00 a.m. to 12:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: James W Mack, Ph.D., Scientific Review Officer...

  19. 76 FR 70463 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2011-11-14

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis..., National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892- 9550, (301) 435-1439, lf33c.nih.gov . Name of Committee: National Institute on Drug Abuse Special...

  20. 32 CFR 732.20 - Adjudication authorities.

    Science.gov (United States)

    2010-07-01

    ... Medical Affairs, Bethesda, MD 20814, Tele: (A/V) 295-5322 or (C) (301) 295-5322. (3) Mid-Atlantic Region... Medical Command, Mid-Atlantic Region, 6500 Hampton Boulevard, Norfolk, VA 23502, Attn: Office of Medical..., Roosevelt Roads, PR), for dental care rendered in Puerto Rico, the Virgin Islands, and other Caribbean...

  1. 76 FR 11499 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-02

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel; 2011 LRP Panel 1. Date: March 18, 2011. Time: 8 a.m. to... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 451-9536, [email protected

  2. 76 FR 14673 - National Center on Minority and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-17

    ... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel; 2011 LRP Panel 3. Date: April 13, 2011. Time: 8 a.m. to... Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 451-9536, [email protected

  3. 78 FR 13689 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2013-02-28

    ... Minority Health and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... and Health Disparities Special Emphasis Panel. Date: March 8, 2013. Time: 8:00 a.m. to 5:00 p.m..., and Health Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892, (301) 496-3996...

  4. 75 FR 19408 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-14

    [email protected]csr.nih.gov . Name of Committee: Healthcare Delivery and Methodologies, Community-Level Health...-1503, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis..., Bethesda, MD 20892, 301-435- 2406, [email protected]csr.nih.gov . Name of Committee: Oncology 2--Translational...

  5. 78 FR 17219 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-03-20

    ..., Bethesda, MD 20892, (301) 435-1166, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict: Biopsychosocial Issues in Patient Management. Date: April 10... 20892, 301-435-1719, [email protected]csr.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.306...

  6. 75 FR 44271 - Office of the Director; Notice of Closed Meeting

    Science.gov (United States)

    2010-07-28

    ... 20892. Contact Person: Lawrence A. Tabak, PhD, DDS, Acting Director, Division of Program Coordination..., Building 31, Room 2C39, Bethesda, MD 20892, 301- 496-3571, lawrence[email protected] . This notice is being.... Dated: July 22, 2010. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc...

  7. Asthma - Multiple Languages

    Science.gov (United States)

    ... XYZ List of All Topics All Asthma - Multiple Languages To use the sharing features on this page, please enable JavaScript. Arabic (العربية) ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on 2 May 2018

  8. 78 FR 52513 - Sunshine Act Meeting; Cancellation

    Science.gov (United States)

    2013-08-23

    ..., August 21, 2013, page 51713. ANNOUNCED TIME AND DATE OF MEETING: Wednesday, August 21, 2013, 10 a.m.-11 a.m. MEETING CANCELED. For a recorded message containing the latest agenda information, call (301) 504... West Highway, Bethesda, MD 20814 (301) 504- 7923. Dated: August 21, 2013. Todd A. Stevenson, Secretary...

  9. Learning Physical Domains: Toward a Theoretical Framework.

    Science.gov (United States)

    1986-12-01

    advanced ids o the iaime doinain in containing more information, especially perceptual " ’It. iho lI b1 rwt... tI hat. psychboigists by no means...Acquisitions Dr Kenneth D Forbus 4833 Rugby Avenue University of Illinois Dr Robert Glaser Bethesda, MD 20014 Department of Computer Science Learning

  10. Research

    African Journals Online (AJOL)

    abp

    2012-06-04

    Jun 4, 2012 ... The median total, indirect and direct annual costs to rural ambulating HIV/AIDS ... and other indirect cost such as transportation cost and waiting time amongst others. ... Unit costs for calculating indirect costs for the unemployed were based on .... Bethesda, MD, Partners for Health Reform-plus Project; 2003.

  11. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-09] Scott W. Houghton, M.D... CFR 0.100(b), I order that DEA Certificate of Registration BH8796077, issued to Scott W. Houghton, M.D., be, and it hereby is, revoked. I further order that any pending application of Scott W. Houghton, M.D...

  12. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    Crowley, M F; Nimlos, M R; Himmel, M E; Uberbacher, E C; Iii, C L Brooks; Walker, R C

    2008-01-01

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  13. Trends in MD/PhD Graduates Entering Psychiatry: Assessing the Physician-Scientist Pipeline.

    Science.gov (United States)

    Arbuckle, Melissa R; Luo, Sean X; Pincus, Harold Alan; Gordon, Joshua A; Chung, Joyce Y; Chavez, Mark; Oquendo, Maria A

    2018-06-01

    The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology). Linear regression and multiple linear regression determined whether these values increased over time and varied by sex. Over 14 years, an average of 18 MD/PhDs (range 13-29) enrolled in psychiatry each year. The number of MD/PhDs going into psychiatry significantly increased, although these gains were modest (less than one additional MD/PhD per year). The proportion of students entering psychiatry who were MD/PhDs varied between 2.9 and 5.9 per 100 residents, with no significant change over time. There was also no change in the percentage of MD/PhDs entering psychiatry from among all MD/PhD graduates. The rate of increase in the number of MD/PhDs going into psychiatry did not differ significantly from other specialties except for family medicine, which is decreasing. The rate of MD/PhDs going into psychiatry was higher for women, suggesting closure of the sex gap in 17 years. Despite the increase in the number of MD/PhDs entering psychiatry, these numbers remain low. Expanding the cohort of physician-scientists dedicated to translational research in psychiatry will require a multipronged approach.

  14. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  15. Clinical use of gadobutrol for contrast-enhanced magnetic resonance imaging of neurological diseases

    Directory of Open Access Journals (Sweden)

    Cheng KT

    2012-02-01

    Full Text Available Kenneth T Cheng1, Hannah Y Cheng2, Kam Leung31Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA; 2Freelance Technical Writer, New Orleans, LA, USA; 3National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USAAbstract: Contrast-enhanced magnetic resonance imaging (CE-MRI is an important clinical tool for diagnosing neurological diseases. The appropriate use of a suitable MRI contrast agent or contrast pharmaceutical is essential for CE-MRI to produce desirable diagnostic images. Currently, there are seven contrast agents (CAs or pharmaceuticals approved for clinical imaging of the central nervous system (CNS in the US, Europe, or Japan. All of the clinically approved CAs are water-soluble gadolinium-based contrast agents (GBCAs which do not penetrate the CNS blood–brain barrier (BBB. These agents are used for imaging CNS areas without a BBB, or various pathologies, such as tumors and infection that break down the BBB and allow CAs to enter into the surrounding parenchyma. Clinically, GBCAs are most useful for detecting primary and secondary cerebral neoplastic lesions. Among these CNS GBCAs, gadobutrol (Gd-BT-DO3A, Gadovist™ is a neutral, nonionic, macrocyclic compound that showed promising results from clinical trials of CNS imaging. In comparison with other GBCAs, Gd-BT-DO3A has relatively high in vitro kinetic stability and r1 relaxivity. Gd-BT-DO3A has been recently approved by the US Food and Drug Administration (FDA in 2011 for CNS imaging. A review of available literature shows that Gd-BT-DO3A exhibits similar safety and clinical efficacy profiles to other GBCAs. Gd-BT-DO3A has the distinguishing feature that it is the only clinical agent commercially available in a formulation of 1.0 M concentration with a relatively higher in vitro T1 shortening per unit volume than other clinical GBCAs which are only

  16. 77 FR 61419 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2012-10-09

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel. Date: October 30, 2012. Time: 3:00 p... Institute Of Child Health And Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  17. 77 FR 64835 - Sunshine Act Meeting

    Science.gov (United States)

    2012-10-23

    ...:30 p.m. Briefing on Security issues (Closed Ex-1) * The schedule for Commission meetings is subject...), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852 Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2) Week of November 12, 2012--Tentative There are no meetings...

  18. 75 FR 64367 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-10-19

    ..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Week of November 1, 2010--Tentative... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting). (Contact: Michael Fuller, 301-415-0520.) This meeting will be...

  19. 77 FR 47654 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-08-09

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel Collaborative Clinical Trials in Drug Abuse--PAR 10- 099. Date: October 4, 2012. Time: 11 a.m. to... on Drug Abuse, NIH, DHHS, 6001 Executive Blvd., Room 4238, MSC 9550, Bethesda, MD 20892-9550, 301-402...

  20. 78 FR 14099 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-03-04

    ..., (301) 435-1165, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Biopsychosocial Issues in Patient Management. Date: March 22, 2013. Time: 3:00 p..., Bethesda, MD 20892, 301-435-2365, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review...

  1. Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid

    Directory of Open Access Journals (Sweden)

    Simon Sung

    2017-01-01

    Full Text Available Background: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal and Bethesda category IV (Beth-IV thyroid follicular lesions, which carry a 15%–30% risk of malignancy and are often followed up with surgical resection. Methods: A search was performed to identify “parathyroid” diagnoses in parathyroid/thyroid-designated fine-needle aspirations (FNAs and Beth-IV thyroid FNAs (follicular and Hurthle cell, all with diagnostic confirmation through surgical pathology, immunocytochemical stains, Afirma® analysis, and/or clinical correlation. Unique cytomorphologic features were scored (0-3 or noted as present versus absent. Statistical analysis was performed using R 3.3.1 software. Results: We identified five FNA cases with clinical suspicion of parathyroid neoplasm, hyperthyroidism, or thyroid lesion that had an eventual final diagnosis of the parathyroid lesion (all female; age 20–69 years and 12 Beth-IV diagnoses (11 female, 1 male; age 13–64 years. The following cytomorphologic features are useful distinguishing features (P value: overall pattern (0.001, single cells (0.001, cell size compared to red blood cell (0.01, nuclear irregularity (0.001, presence of nucleoli (0.001, nuclear-to-cytoplasmic ratio (0.007, and nuclear chromatin quality (0.028. Conclusions: There are cytomorphologic features that distinguish Beth-IV thyroid lesions and (intrathyroidal parathyroid. These features can aid in rendering correct diagnoses and appropriate management.

  2. 3MdB: the Mexican Million Models database

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  3. Trees in urban parks and forests reduce O3, but not NO2 concentrations in Baltimore, MD, USA

    Science.gov (United States)

    Yli-Pelkonen, Vesa; Scott, Anna A.; Viippola, Viljami; Setälä, Heikki

    2017-10-01

    Trees and other vegetation absorb and capture air pollutants, leading to the common perception that they, and trees in particular, can improve air quality in cities and provide an important ecosystem service for urban inhabitants. Yet, there has been a lack of empirical evidence showing this at the local scale with different plant configurations and climatic regions. We studied the impact of urban park and forest vegetation on the levels of nitrogen dioxide (NO2) and ground-level ozone (O3) while controlling for temperature during early summer (May) using passive samplers in Baltimore, USA. Concentrations of O3 were significantly lower in tree-covered habitats than in adjacent open habitats, but concentrations of NO2 did not differ significantly between tree-covered and open habitats. Higher temperatures resulted in higher pollutant concentrations and NO2 and O3 concentration were negatively correlated with each other. Our results suggest that the role of trees in reducing NO2 concentrations in urban parks and forests in the Mid-Atlantic USA is minor, but that the presence of tree-cover can result in lower O3 levels compared to similar open areas. Our results further suggest that actions aiming at local air pollution mitigation should consider local variability in vegetation, climate, micro-climate, and traffic conditions.

  4. Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

    Directory of Open Access Journals (Sweden)

    Cheolhoon Kim

    2017-11-01

    Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

  5. Apple F-box Protein MdMAX2 Regulates Plant Photomorphogenesis and Stress Response

    Directory of Open Access Journals (Sweden)

    Jian-Ping An

    2016-11-01

    Full Text Available MAX2 (MORE AXILLARY GROWTH2 is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length. Further study indicated that MdMAX2 might promote plant photomorphogenesis by affecting the auxin signaling as well as other plant hormones. Transcripts of MdMAX2 were noticeably up-regulated in response to NaCl and Mannitol treatments. Moreover, compared with the wild type, the MdMAX2-overexpressing apple calli and Arabidopsis exhibited increased tolerance to salt and drought stresses. Taken together, these results suggest that MdMAX2 plays a positive regulatory role in plant photomorphogenesis and stress response.

  6. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  7. 77 FR 16247 - Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed...

    Science.gov (United States)

    2012-03-20

    ... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-L 55 2. Date: April 10... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892...

  8. 76 FR 61720 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2011-10-05

    ... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, PAR-10-194, PAR10-203, PAR-11- 183... Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01-G, Bethesda, MD 20892...

  9. 78 FR 78982 - National Institute of Allergy and Infectious Diseases; Notice of Meetings

    Science.gov (United States)

    2013-12-27

    ... Committee Act, as amended (5 U.S.C. App.), notice is hereby given of meetings of the AIDS Research Advisory... Committee: AIDS Research Advisory Committee, NIAID. Date: *January 27, 2014. Time: 1:00 p.m. to 5:00 p.m..., Executive Secretary, AIDS Research Advisory Committee, Division of AIDS, NIAID/NIH, Bethesda, MD 20892. 301...

  10. Diabetes HealthSense: Resources for Living Well

    Medline Plus

    Full Text Available ... or school health professional K-8th grade Community health worker Community organization Age Select one: Child Teen and young adult Adult Older adult (65+) Type of Resource Select one: Printable documents Online ... The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-2560, Telephone: 301.496.3583

  11. 75 FR 56554 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-09-16

    ... Health, 6701 Rockledge Drive, Room 4122, MSC 7802, Bethesda, MD 20892, 301-435-1212, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations... meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center...

  12. 78 FR 78985 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-12-27

    ... 7890, Bethesda, MD 20892, (301) 435-1741, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle..., (301) 435-1741, [email protected]csr.nih.gov . Name of Committee: Risk, Prevention and Health Behavior...

  13. 76 FR 14036 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-15

    ..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific... 7852, Bethesda, MD 20892, (301) 435-1166, [email protected]csr.nih.gov . Name of Committee: Center for...

  14. 75 FR 56115 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-09-15

    ... days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name.... (301) 435- 1046. [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis..., Bethesda, MD 20892. 301-435- 1052. [email protected]csr.nih.gov . Name of Committee: Biobehavioral and Behavioral...

  15. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Peter W.S. Grigg, M.D.; Revocation of... Order to Show Cause and Immediate Suspension of Registration to Peter W.S. Grigg, M.D. (Respondent), of... Registration, BG2107856, issued to Peter W.S. Grigg, M.D., be, and it hereby is, revoked. This Order is...

  16. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 117; Issue 6 ... oxidation of methane in coastal sediment from Guishan Island (Pearl River Estuary), South China Sea ... National Institute of Health, Bethesda, Maryland 20892, USA.

  17. Developing the MD Explorer

    Science.gov (United States)

    Howie, Philip V.

    1993-04-01

    The MD Explorer is an eight-seat twin-turbine engine helicopter which is being developed using integrated product definition (IPD) team methodology. New techniques include NOTAR antitorque system for directional control, a composite fuselage, an all-composite bearingless main rotor, and digital cockpit displays. Three-dimensional CAD models are the basis of the entire Explorer design. Solid models provide vendor with design clarification, removing much of the normal drawing interpretation errors.

  18. MD Anderson's Population Health Approaches to Cancer Prevention.

    Science.gov (United States)

    Foxhall, Lewis; Moreno, Mark; Hawk, Ernest

    2018-02-01

    Texas's size and unique population demographics present challenges to addressing the state's cancer burden. The University of Texas MD Anderson Cancer Center is one of 69 National Cancer Institute-designated cancer centers across the United States. While these centers traditionally have focused on research, education and training, and providing research-driven patient care, they are in a unique position to collaboratively advance population health through cancer control. Unlike the traditional academic model of a three-legged stool representing research, education, and patient care, MD Anderson's mission includes a fourth leg that incorporates population health approaches. MD Anderson has leveraged state- and national-level data and freely available resources to develop population-health priorities and a set of evidence-based actions across policy, public and professional education, and community-based clinical service domains to address these priorities. Population health approaches complement dissemination and implementation research and treatment, and will be increasingly needed to address the growing cancer burden in Texas and the nation.

  19. 78 FR 19499 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-01

    ... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel PAR-12-297: Mechanism for Time-Sensitive Drug Abuse Research. Date: April 9, 2013. Time: 12:00 p.m. to 2:00 p.m. Agenda... Institute on Drug Abuse, NIH, DHHS, 6001 Executive Blvd., Room 4226, MSC 9550, Bethesda, MD 20892-9550, 301...

  20. Structural Shielding Design and Evaluation for Megavoltage X- and Gamma-Ray Radiotherapy Facilities.

    Science.gov (United States)

    Glasgow, Glenn P

    2006-09-01

    Structural Shielding Design and Evaluation for Megavoltage X- and Gamma-Ray Radiotherapy Facilities NCRP Report No. 151, 2005, 246 pp. (Hardcover $100). National Council on Radiation Protection and Measurements, 7910 Woodmont Avenue, Suite 400, Bethesda, MD 20814-3095. ISBN-10 0-0929600-87-8; http://www.NCRPonline.org. © 2006 American Association of Physicists in Medicine.

  1. An Alternative Estimator for the Maximum Likelihood Estimator for the Two Extreme Response Patterns.

    Science.gov (United States)

    1981-06-29

    is the item discrimination parameter and b is the g X g item response difficulty parameter which satisfies (2.3) - = b 0 < b1 < b 2 < ....... < b...Tuscon, AZ 85721 4833 Rugby Avenue Dr. John B. Carroll Bethesda, MD 20014 Psychometric Lab 1 Dr. Leonard Feldt Univ. of No. Carolina Lindquist Center for

  2. 76 FR 17928 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-31

    ...- 0684, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for... Rockledge Drive, Room 4118, MSC 7814, Bethesda, MD 20892, 301-435- 1777, [email protected]csr.nih.gov . Name of...

  3. 77 FR 65004 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-24

    ..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific..., 6701 Rockledge Drive, Room 6210, MSC 7804, Bethesda, MD 20892, 301-435- 1211, [email protected]csr.nih.gov...

  4. 75 FR 27351 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-05-14

    ... 20892, 301-435- 0952, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee... Rockledge Drive, Room 5116, MSC 7854, Bethesda, MD 20892, (301) 435- 1171, [email protected]csr.nih.gov . Name of...

  5. 76 FR 33322 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-06-08

    ...-402-4454, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for..., 6701 Rockledge Drive, Room 6214, MSC 7804, Bethesda, MD 20892, (301)435-3504, [email protected]csr.nih.gov . Name...

  6. 75 FR 55591 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-09-13

    ...-435- 0952, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center... Rockledge Drive, Room 4214, MSC 7814, Bethesda, MD 20892, 301-435- 1781, [email protected]csr.nih.gov . Name of...

  7. 75 FR 4830 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-29

    ..., (301) 435-1767, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center... Health, 6701 Rockledge Drive, Room 3184, MSC 7848, Bethesda, MD 20892, (301) 435-4445, [email protected]csr.nih...

  8. 77 FR 62246 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-12

    [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., 6701 Rockledge Drive, Room 5208, MSC 7852, Bethesda, MD 20892, (301) 435-1165, [email protected]csr.nih.gov...

  9. 76 FR 63315 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-12

    [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special... Rockledge Drive, Room 5110, MSC 7854, Bethesda, MD 20892, (301) 435-1174, [email protected]csr.nih.gov . Name of...

  10. 75 FR 75484 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-12-03

    .... [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific..., Room 4205, MSC 7814, Bethesda, MD 20892. 301-435- 1501. [email protected]csr.nih.gov . This notice is being...

  11. 75 FR 57965 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-09-23

    ... Rockledge Drive, Room 1102, MSC 7760, Bethesda, MD 20892, (301) 435-1747, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by... 20892, 301-435- 1211, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special...

  12. 78 FR 72684 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-12-03

    ...-1246, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for... Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov...

  13. 75 FR 3240 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-20

    ... notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by... 20892, 301-254-9975, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special..., Room 6164, MSC 7892, Bethesda, MD 20892, (301) 435- 1041, [email protected]csr.nih.gov . Name of Committee...

  14. 75 FR 64736 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-10-20

    ...-1215, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for... Health, 6701 Rockledge Drive, Room 6194, MSC 7804, Bethesda, MD 20892, 301-594- 7945, [email protected]csr.nih...

  15. 76 FR 36555 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-06-22

    ...-1219, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for..., Room 5187, MSC 7840, Bethesda, MD 20892, 301-435- 1236, [email protected]csr.nih.gov . Name of Committee...

  16. 77 FR 37685 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-22

    ..., (301) 806-2515, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center... Health, 6701 Rockledge Drive, Room 6214, MSC 7804, Bethesda, MD 20892, 301-451-3493, [email protected]csr.nih.gov...

  17. 75 FR 8370 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-02-24

    [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., Bethesda, MD 20892. 301-435-1159. [email protected]csr.nih.gov . This notice is being published less than 15...

  18. 77 FR 38849 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-29

    ... 20892, 301-435-1038, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee... Health, 6701 Rockledge Drive, Room 5208, MSC 7852, Bethesda, MD 20892, (301) 435-1165, [email protected]csr.nih...

  19. 75 FR 48977 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-08-12

    .... [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific..., Room 5181, MSC 7844, Bethesda, MD 20892. 301-435- 1033. [email protected]csr.nih.gov . Name of Committee: Center...

  20. 77 FR 14533 - Center for Scientific Review: Notice of Closed Meetings

    Science.gov (United States)

    2012-03-12

    ..., Bethesda, MD 20892, 301-408- 9971, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of...-435-1236, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis...

  1. 76 FR 22716 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-04-22

    .... [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific..., Room 6170, MSC 7892, Bethesda, MD 20892, 301-435- 4514. [email protected]csr.nih.gov . Name of Committee...

  2. 78 FR 13361 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-27

    ...-435- 1211, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for..., Bethesda, MD 20892, 301-435-1050, [email protected]csr.nih.gov . This notice is being published less than 15 days...

  3. 75 FR 4095 - Center For Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-26

    ..., (301) 435-1233, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center... Rockledge Drive, Room 5202, MSC 7846, Bethesda, MD 20892, 301-435- 1175, [email protected]csr.nih.gov . Name of...

  4. 76 FR 6803 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-02-08

    ... 20892, (301) 435-1219, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee... Health, 6701 Rockledge Drive, Room 4811, MSC 7850, Bethesda, MD 20892 301-435-1203, [email protected]csr.nih.gov...

  5. 75 FR 9908 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-03-04

    ..., Room 4102, MSC 7814, Bethesda, MD 20892, (301) 435-1786, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Program Project...

  6. 78 FR 48179 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-07

    ... 20892, (301) 435- 1712, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee... Health, 6701 Rockledge Drive, Room 4118A, MSC 7814, Bethesda, MD 20892, 301-435- 5575, [email protected]csr.nih...

  7. 76 FR 12980 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-09

    [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., Bethesda, MD 20892, 301-435-1022, [email protected]csr.nih.gov . Name of Committee: Center for Scientific...

  8. 76 FR 28793 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-05-18

    ...-435- 0696, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Oncology 2..., Room 6214, MSC 7804, Bethesda, MD 20892, 301-451- 3493, [email protected]csr.nih.gov . This notice is being...

  9. 77 FR 59198 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-26

    ... 20892, (301) 435-1741, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee... Institutes of Health, 6701 Rockledge Drive, Room 5170, MSC 7840, Bethesda, MD 20892, 301-435-2406, [email protected]csr...

  10. 76 FR 13421 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-11

    ..., Room 3136, MSC 7759, Bethesda, MD 20892. (301) 435-1258. [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and.... [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel, Cancer...

  11. 76 FR 17929 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-31

    ...-435- 1050, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for... Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov...

  12. 77 FR 45366 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2012-07-31

    ....S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C..., Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Yi-Hsin Liu, Ph.D., Scientific Review...

  13. 78 FR 27243 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-09

    ... U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C... Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Yi-Hsin Liu, Ph.D., Scientific Review...

  14. 76 FR 7572 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-02-10

    ... U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C... Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Yi-Hsin Liu, PhD...

  15. 76 FR 17673 - Bienvenido Tan, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-30

    ... (alprazolam) to help him sleep. Id. at 64. R.E. opted to buy the drugs from Respondent's dispensary and... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-12] Bienvenido Tan, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Bienvenido Tan, M.D...

  16. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng; Cui, Yue; Ge, Qingchun; Fern Tew, Tjin; Chung, Neal Tai-Shung

    2015-01-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  17. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  18. A single institution experience with the new bethesda system for reporting thyroid cytopathology: correlation with existing cytologic, clinical, and histological data.

    Science.gov (United States)

    McElroy, Michele K; Mahooti, Sepi; Hasteh, Farnaz

    2014-07-01

    Our goal was to evaluate the Bethesda system (TBS) in comparison to the previously used system at our institution. One hundred consecutive thyroid fine needle aspirations (FNAs) and 45 consecutive indeterminate FNAs were reviewed by two cytopathology-boarded pathologists, diagnosed based on TBS and correlated with management and follow-up. Re-evaluation led to a diagnosis change in 48% of cases. Thirty-nine percent of benign cases were unsatisfactory under TBS. For malignant diagnoses the positive predictive value (PPV) was unchanged, while the negative predictive value (NPV) was slightly improved using TBS. Both the PPV and NPV were improved for actionable diagnoses. Inter-observer variability across all categories was in moderate agreement. Clinical management of both follicular lesion (FL) and indeterminate cases ranged from none to immediate surgery. Repeat FNA resolved the diagnosis in 50% of indeterminate cases. Indeterminate cases had an overall malignancy rate of 27%; higher in pre- (46%) than post-TBS cases (8%). Inter-observer variability between the reviewing pathologists and the original pathologists for indeterminate cases was fair, and between the two reviewing pathologists was moderate. Using TBS criteria increased the unsatisfactory rate and led to improved prediction of malignancy and actionable diagnoses. The pre-Bethesda diagnosis of FL at our institution led to inconsistent clinical management. Clinical management of patients with indeterminate diagnoses was essentially unchanged following adoption of TBS. The moderate inter-observer agreement between the reviewing pathologists may be related to level of cytology experience, strict adherence to TBS, and the exclusive use of cytomorphology for diagnosis. © 2014 Wiley Periodicals, Inc.

  19. Development of a Bayesian model to estimate health care outcomes in the severely wounded

    Directory of Open Access Journals (Sweden)

    Alexander Stojadinovic

    2010-08-01

    Full Text Available Alexander Stojadinovic1, John Eberhardt2, Trevor S Brown3, Jason S Hawksworth4, Frederick Gage3, Douglas K Tadaki3, Jonathan A Forsberg5, Thomas A Davis3, Benjamin K Potter5, James R Dunne6, E A Elster31Combat Wound Initiative Program, 4Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA; 2DecisionQ Corporation, Washington, DC, USA; 3Regenerative Medicine Department, Combat Casualty Care, Naval Medical Research Center, Silver Spring, MD, USA; 5Integrated Department of Orthopaedics and Rehabilitation, 6Department of Surgery, National Naval Medical Center, Bethesda, MD, USABackground: Graphical probabilistic models have the ability to provide insights as to how clinical factors are conditionally related. These models can be used to help us understand factors influencing health care outcomes and resource utilization, and to estimate morbidity and clinical outcomes in trauma patient populations.Study design: Thirty-two combat casualties with severe extremity injuries enrolled in a prospective observational study were analyzed using step-wise machine-learned Bayesian belief network (BBN and step-wise logistic regression (LR. Models were evaluated using 10-fold cross-validation to calculate area-under-the-curve (AUC from receiver operating characteristics (ROC curves.Results: Our BBN showed important associations between various factors in our data set that could not be developed using standard regression methods. Cross-validated ROC curve analysis showed that our BBN model was a robust representation of our data domain and that LR models trained on these findings were also robust: hospital-acquired infection (AUC: LR, 0.81; BBN, 0.79, intensive care unit length of stay (AUC: LR, 0.97; BBN, 0.81, and wound healing (AUC: LR, 0.91; BBN, 0.72 showed strong AUC.Conclusions: A BBN model can effectively represent clinical outcomes and biomarkers in patients hospitalized after severe wounding, and is confirmed by 10-fold

  20. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ...-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD AGENCY: Coast Guard, DHS. ACTION: Notice... operation of the Baltimore County highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

  1. Analysis of MD5 authentication in various routing protocols using simulation tools

    Science.gov (United States)

    Dinakaran, M.; Darshan, K. N.; Patel, Harsh

    2017-11-01

    Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

  2. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, Noreddine

    2016-09-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  3. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, NorEddine; Francis, Lijo; Li, Zhenyu; Valladares, Rodrigo; Alsaadi, Ahmad S.; Ghdaib, Muhannad Abu; Amy, Gary L.

    2016-01-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  4. 33 CFR 110.70a - Northeast River, North East, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

  5. Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

    Directory of Open Access Journals (Sweden)

    Nurvita Septya Ningrum

    2016-10-01

    Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

  6. 77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

    Science.gov (United States)

    2012-05-18

    ... CFR 1316.67. Dated: May 4, 2012. Michele M. Leonhart, Administrator. Paul E. Soeffing, Esq., for the... reinstatement.'' Stuart A. Bergman, M.D., 70 Fed. Reg. 33,193 (DEA 2005); Roger A. Rodriguez, M.D., 70 Fed. Reg...

  7. 77 FR 35021 - Kwan Bo Jin, M.D.; Decision and Order

    Science.gov (United States)

    2012-06-12

    ...] DEA registration is not appropriate.'' Anibal P. Herrera, M.D., 61 FR 65,075, 65,078 (DEA 1996); see... ``there were serious questions as to the integrity of the registrant.'' Anibal P. Herrera, M.D., 61 FR 65...

  8. Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

    Directory of Open Access Journals (Sweden)

    Jin Zhao

    2016-03-01

    Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

  9. A pilot study of MD (psychiatry) theses-based research.

    Science.gov (United States)

    Srivastava, Shrikant; Agarwal, Vivek; Subramanyam, Alka; Srivastava, Mona; Sathyanarayana Rao, T S; Rao, G Prasad; Khurana, Hitesh; Singh, Archana

    2018-01-01

    Undertaking a research project is mandatory for MD Psychiatry trainees. The present study was undertaken to assess the type of research activity being undertaken as part of MD Psychiatry dissertation, and its contribution to national and international literature. Three medical colleges supplied the data about the topic, names of the supervisor and the candidate, collaboration, funding accrued, and publication details of MD-based research carried out between years 2000 and 2010 inclusive; 95 records were collected for the final analysis. The details of the publications provided were cross-checked on the internet, which would have taken care of missed publications as well. Most studies were single-point assessment clinical studies. Only 2 studies had been funded, 11 had collaboration with other departments within the same institute, and 5 had inter-institute collaborations. Majority of the studies were not published. Only 30 were published as full paper and 9 as abstracts. Of these 30 full publications, only 3 were published in journals having JCI impact factor values (1.4, 1.3, and 1.4, respectively). The main finding of this pilot study was that MD-based research has low contribution to the national and international literature, and those articles which are published are in low impact journals. Suggestions for modifying this state of affairs are discussed.

  10. MD 2485: Active halo control using narrowband and colored noise excitations

    CERN Document Server

    Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

  11. Indirect comparisons of second-generation tyrosine kinase inhibitors in CML: case study using baseline population characteristics

    Directory of Open Access Journals (Sweden)

    Kimbach Tran Carpiuc

    2010-10-01

    Full Text Available Kimbach Tran Carpiuc1, Gianantonio Rosti2, Fausto Castagnetti2, Maarten Treur3, Jennifer Stephens11Pharmerit North America LLC, Bethesda, MD, USA; 2Department of Hematology and Oncology, S Orsola-Malpighi University Hospital, Bologna, Italy; 3Pharmerit Europe, Rotterdam, The NetherlandsAbstract: The use of indirect comparisons to evaluate the relative effectiveness between two or more treatments is widespread in the literature and continues to grow each year. Appropriate methodologies will be essential for integrating data from various published clinical trials into a systematic framework as part of the increasing emphasis on comparative effectiveness research. This article provides a case study example for clinicians using the baseline study population characteristics and response rates of the tyrosine kinase inhibitors in imatinib-resistant or imatinib-intolerant chronic myelogenous leukemia followed by a discussion of indirect comparison methods that are being increasingly implemented to address challenges with these types of comparisons.Keywords: comparative effectiveness research, meta-analysis, BCR–ABL-positive chronic myelogenous leukemia, imatinib mesylate, nilotinib, dasatinib 

  12. Characterization and evolution of dermal filaments from patients with Morgellons disease

    Directory of Open Access Journals (Sweden)

    Middelveen MJ

    2013-01-01

    Full Text Available Marianne J Middelveen,1 Peter J Mayne,1 Douglas G Kahn,2 Raphael B Stricker11International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Department of Pathology, Olive View–UCLA Medical Center, Sylmar, CA, USAAbstract: Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either self-implanted by patients or accidentally adhering to lesions, and conclude that patients with this disease have delusions of infestation. We present histological observations and electron microscopic imaging from representative Morgellons disease samples revealing that dermal filaments in these cases are keratin and collagen in composition and result from proliferation and activation of keratinocytes and fibroblasts in the epidermis. Spirochetes were detected in the dermatological specimens from our study patients, providing evidence that Morgellons disease is associated with an infectious process.Keywords: Morgellons disease, digital dermatitis, Lyme disease, Borrelia burgdorferi, spirochetes, keratin, keratinocytes, collagen, fibroblasts

  13. Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169

    Science.gov (United States)

    Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

    2018-01-01

    Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3–6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0–4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications. PMID:29293588

  14. Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169.

    Science.gov (United States)

    Lyman, Mathew; Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

    2018-01-01

    Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3-6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0-4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications.

  15. 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia.

    Science.gov (United States)

    Wood, Brent L; Arroz, Maria; Barnett, David; DiGiuseppe, Joseph; Greig, Bruce; Kussick, Steven J; Oldaker, Teri; Shenkin, Mark; Stone, Elizabeth; Wallace, Paul

    2007-01-01

    Immunophenotyping by flow cytometry has become standard practice in the evaluation and monitoring of patients with hematopoietic neoplasia. However, despite its widespread use, considerable variability continues to exist in the reagents used for evaluation and the format in which results are reported. As part of the 2006 Bethesda Consensus conference, a committee was formed to attempt to define a consensus set of reagents suitable for general use in the diagnosis and monitoring of hematopoietic neoplasms. The committee included laboratory professionals from private, public, and university hospitals as well as large reference laboratories that routinely operate clinical flow cytometry laboratories with an emphasis on lymphoma and leukemia immunophenotyping. A survey of participants successfully identified the cell lineage(s) to be evaluated for each of a variety of specific medical indications and defined a set of consensus reagents suitable for the initial evaluation of each cell lineage. Elements to be included in the reporting of clinical flow cytometric results for leukemia and lymphoma evaluation were also refined and are comprehensively listed. The 2006 Bethesda Consensus conference represents the first successful attempt to define a set of consensus reagents suitable for the initial evaluation of hematopoietic neoplasia. Copyright 2007 Clinical Cytometry Society.

  16. Murine Model of Repeated Exposures to Conspecific Trained Aggressors Simulates Features of Post-Traumatic Stress Disorder

    Science.gov (United States)

    2012-07-20

    MD; Naval Medical Research Center, Silver Spring MD U.S. Army Medical Research and Materiel Command 504 Scott Street Fort Detrick, MD 21702...Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, MD, USA Naval Medical Research Center, Silver Spring, MD, USA i g h l i g h t s...thickness of 100 m. Every third cryostat section intervals of 300 m) was mounted on gelatin -coated sides, stained, dehydrated n ethanol, cleared in

  17. 78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

    Science.gov (United States)

    2013-08-05

    ... Green, Jr., M.D., 59 FR 51,453 (DEA 1994); David E. Trawick, D.D.S., 53 FR 5,326 (DEA 1988). Here, the...) (ten years); Norman Alpert, M.D., 58 FR 67,420, 67,421 (DEA 1993) (seven years). Here, the conditions...

  18. Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jianping AN

    2017-03-01

    Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

  19. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

  20. Eliminating Late Recurrence to Eradicate Breast Cancer

    Science.gov (United States)

    2015-09-01

    Annual Clinical Investigator Trainee Meeting, NIH, Bethesda, MD. Prepared: September 23, 2015 2013 - Dinner Speaker, Regional Meeting of HHMI...in 3D culture [51]. Autophagy inhibition attenuated invasion and caused a partial reversion of EMT. Additionally, impaired self- eating led to...point to a complex relationship between self- eating and metastasis [56]. Hence, additional work is needed to establish the cellular functions for

  1. The Structure of Analogical Models in Science.

    Science.gov (United States)

    1980-07-01

    mapping M of the nodes b1 , b2 ,...,bn of system B into the (different) nodes t1, t2,...,tm of system T. (2) The mapping is such that substantial parts... Rugby Avenue Livingstone Road Bethesda, MD 20014 Stratford London E15 2LJ 1 Dr. A. J. Eschenbrenner ENGLAND Dept. E422, Bldg. 81 McDonnell Douglas

  2. A Componential Approach to Training Reading Skills.

    Science.gov (United States)

    1983-03-17

    1 syllable, mixed vowels A2 16 one-syll., 4 two-syll., mixed vowels A3 14 one-syll., 6 two-syll., mixed vowels A4 All two-syllable, mixed vowels* B1 ...06520 I ERIC Facility-Acquisitions I Dr. John S. Brown 4833 Rugby Avenue XEROX Palo Alto Research Center Bethesda, MD 20014 3333 Coyote Road Palo Alto, CA

  3. 76 FR 65738 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-24

    ..., Bethesda, MD 20892, (301) 435-1166, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the...

  4. 76 FR 3916 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-21

    ... 7848, Bethesda, MD 20892, (301) 435-4445, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle... 20892, 301-435- 0677, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the...

  5. 77 FR 48526 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-08-14

    ..., Bethesda, MD 20892, 301-435- 1050, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing...

  6. 78 FR 78984 - Center For Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-12-27

    ... 7852, Bethesda, MD 20892, 301-435- 1050, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing...

  7. 75 FR 70272 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-11-17

    ... 7759, Bethesda, MD 20892, 301-435- 2889, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the...

  8. 77 FR 72362 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-12-05

    ..., Bethesda, MD 20892, (301) 435-1165, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to...

  9. 78 FR 67375 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-12

    ..., Room 6214, MSC 7804, Bethesda, MD 20892, (301) 435-5877, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and...-435- 1050, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting...

  10. 77 FR 73475 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-12-10

    ..., Bethesda, MD 20892, 301-402-4454, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the...

  11. 76 FR 8751 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-02-15

    ..., Bethesda, MD 20892, 301-435- 0903, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of...-1215, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due...

  12. Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

    International Nuclear Information System (INIS)

    Ohto, Umeharu; Satow, Yoshinori

    2008-01-01

    Twinned crystals of humaan MD-2 are transformed into single crystals with cryoprotectant optimization. Twinning of crystals causes overlapping of two or more reciprocal lattice points, and hence structure amplitudes for a single crystalline domain are hardly obtained from X-ray diffraction intensities. MD-2 protein forms a stable complex with Toll-like receptor 4 and recognizes bacterial lipopolysaccharide (LPS). Excessive immune responses activated by LPS cause septic shocks. Saccharide-trimmed human MD-2 crystallizes in the tetragonal form with apparent Laue symmetry of 4/mmm, and diffraction intensities from these crystals indicate crystal twinning. The crystal consists of two different domains, A and B. The c A axis of domain A coincides with the c B axis of domain B with a smaller lattice, and the a A axis corresponds to the (a B + b B ) axis. This twinning severely imposes difficulty in structure determination. Through optimization of cryoprotectant, domain A was thoroughly transformed into domain B. The crystal containing only domain B is in space group P4 1 2 1 2 with one MD-2 molecule in the asymmetric unit. The structure of this form of MD-2 as well as its complex with antiendotoxic lipid IVa was successfully determined using the multiple isomorphous replacement method

  13. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  14. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    Science.gov (United States)

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Center of excellence for mobile sensor data-to-knowledge (MD2K).

    Science.gov (United States)

    Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

    2015-11-01

    Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. MdHB1 down-regulation activates anthocyanin biosynthesis in the white-fleshed apple cultivar 'Granny Smith'.

    Science.gov (United States)

    Jiang, Yonghua; Liu, Cuihua; Yan, Dan; Wen, Xiaohong; Liu, Yanli; Wang, Haojie; Dai, Jieyu; Zhang, Yujie; Liu, Yanfei; Zhou, Bin; Ren, Xiaolin

    2017-02-01

    Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple). Moreover, flowers of transgenic tobacco (Nicotiana tabacum 'NC89') overexpressing MdHB1 showed a remarkable reduction in pigmentation. Transient promoter activation assays and yeast one-hybrid results indicated that MdHB1 indirectly inhibited expression of the anthocyanin biosynthetic genes encoding dihydroflavonol-4-reductase (DFR) and UDP-glucose:flavonoid 3-O-glycosyltransferase (UFGT). Yeast two-hybrid and bimolecular fluorescence complementation determined that MdHB1 acted as a homodimer and could interact with MYB, bHLH, and WD40 in the cytoplasm, consistent with its cytoplasmic localization by green fluorescent protein fluorescence observations. Together, these results suggest that MdHB1 constrains MdMYB10, MdbHLH3, and MdTTG1 to the cytoplasm, and then represses the transcription of MdDFR and MdUFGT indirectly. When MdHB1 is silenced, these TFs are released to activate the expression of MdDFR and MdUFGT and also anthocyanin biosynthesis, resulting in red flesh in 'Granny Smith'. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. The hydration enthalpies of Md3+ and Lr3+

    International Nuclear Information System (INIS)

    Bruechle, W.; Schaedel, M.; Scherer, U.W.; Kratz, J.V.

    1987-10-01

    Lawrencium (3-min 260 Lr) and lighter actinides were produced in the bombardement of a 249 Bk target with 18 O ions and loaded onto a cation exchange column in 0.05 M α-hydroxy-isobutyrate solution at pH = 4.85 together with the radioactive lanthanide tracers 166 Ho, 171 Er, and 171 Tm. In elutions with 0.12 M α-hydroxy-isobutyrate solution (pH = 4.85) trivalent Lr was eluted exactly together with the Er tracer and Md close to Ho. Lr elutes much later than expected based on the known elution positions of the lighter actinides and the expected analogy to the elution positions of the homologous lanthanides. From the measured elution positions, ionic radii were calculated for Lr 3+ and Md 3+ . Semiempirical models allow the calculation of the heat of hydration from the ionic radii, resulting in ΔH hyd ≅ - 3654 kJ/mol for Md 3+ and ΔH hyd ≅ - 3689 kJ/mol for Lr 3+ . (orig.)

  18. Multimodal assessment of visual attention using the Bethesda Eye & Attention Measure (BEAM).

    Science.gov (United States)

    Ettenhofer, Mark L; Hershaw, Jamie N; Barry, David M

    2016-01-01

    Computerized cognitive tests measuring manual response time (RT) and errors are often used in the assessment of visual attention. Evidence suggests that saccadic RT and errors may also provide valuable information about attention. This study was conducted to examine a novel approach to multimodal assessment of visual attention incorporating concurrent measurements of saccadic eye movements and manual responses. A computerized cognitive task, the Bethesda Eye & Attention Measure (BEAM) v.34, was designed to evaluate key attention networks through concurrent measurement of saccadic and manual RT and inhibition errors. Results from a community sample of n = 54 adults were analyzed to examine effects of BEAM attention cues on manual and saccadic RT and inhibition errors, internal reliability of BEAM metrics, relationships between parallel saccadic and manual metrics, and relationships of BEAM metrics to demographic characteristics. Effects of BEAM attention cues (alerting, orienting, interference, gap, and no-go signals) were consistent with previous literature examining key attention processes. However, corresponding saccadic and manual measurements were weakly related to each other, and only manual measurements were related to estimated verbal intelligence or years of education. This study provides preliminary support for the feasibility of multimodal assessment of visual attention using the BEAM. Results suggest that BEAM saccadic and manual metrics provide divergent measurements. Additional research will be needed to obtain comprehensive normative data, to cross-validate BEAM measurements with other indicators of neural and cognitive function, and to evaluate the utility of these metrics within clinical populations of interest.

  19. 76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Science.gov (United States)

    2011-12-29

    ... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to... five hours advance notice is given. The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke...

  20. The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

    Science.gov (United States)

    Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

    2017-05-01

    MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

  1. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    International Nuclear Information System (INIS)

    Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

    2014-01-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors

  2. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  3. MD#2183: Calibration of the IR6 B2 diamond BLMs

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip

    2018-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine, causing ~40 bunches to impact on the movable dump protection absorber (TCDQ), it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IR6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the TCDQ downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with a dynamic range of several orders of magnitude; thus, allowing to derive the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. During this first MD only the Beam 1 dBLM was calibrated appropriately, a second calibration MD was therefore performed in 2017 for the B2 system. Results from this MD and conclusions regarding dBLM saturation with a top energy nominal...

  4. Predicting Attrition in a Military Special Program Training Command

    Science.gov (United States)

    2016-05-20

    made by assessing additional psychological factors. Specifically, motivation (s) to enter the training program (e.g., intrinsic versus extrinsic ...this and other training programs. Motivations to enter the training program could be assessed using a measure such as the Work Extrinsic and...MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814 APPROVAL OF THE DOCTORAL DISSERTATION IN THE

  5. Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum

    Science.gov (United States)

    2010-06-17

    Sciences, Bethesda, MD, ...... 14. ABSTRACT Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is...parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of...Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum Carmenza Spadafora1,2,3, Gordon A. Awandare4

  6. Tumor Microenvironment and Progression to Invasion after a Diagnosis of Ductal Carcinoma In Situ

    Science.gov (United States)

    2013-11-01

    Distribution Unlimited The views , opinions and/or findings contained in this report are those...study of cases diagnosed between 1995 and 2006, this gap had narrowed to 3.1 versus 1.3 %, respectively. These results suggest that in community practice...Ruhl J, Tatalovich Z, Cho H et al (2012) SEER cancer statistics review, 1975–2009. National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/ csr

  7. Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

    OpenAIRE

    Middelveen, Marianne J; Stricker, Raphael B

    2011-01-01

    Marianne J Middelveen, Raphael B StrickerInternational Lyme and Associated Diseases Society, Bethesda, MD, USAAbstract: Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coi...

  8. Is Bayesian Estimation Proper for Estimating the Individual’s Ability?

    Science.gov (United States)

    1980-07-15

    8217 . LA Q__ .. ’ LL * L .51 , 27 _ :...~ 2,1O34 4 . __8 13 .2, . ,.. 4 .. 04_I ’jag.. * b1 1, 9. 73,-- o __ - 1.., 9 ’.2 ;’ " *~~ 2 2 5g.S , .4. ’ " 0...University of Massechusetts Amherst, MA 01002 ERIC Facility-Acquisitions 4833 Rugby Avenue 1 Dr. Chester Harris Bethesda, MD 20014 School of Education

  9. Microstructural Effects on the Spall Properties of ECAE-Processed AZ31B Magnesium Alloy

    Science.gov (United States)

    2016-10-01

    stresses using 51 mm and 105 mm bore gas guns . The Hugoniot Elastic Limit (HEL) was measured to be approximately 181 ± 3 MPa. The spall strengths...MD 21218, USA b Institute of Shock Physics, Imperial College London, London SW7 2AZ, UK c U.S. Army Research Laboratory, Aberdeen Proving Ground, MD...21005, USA d Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA A R T I C L E I N F O Article history: Received

  10. USA

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html......http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html...

  11. The interobserver reproducibility of thyroid cytopathology using Bethesda Reporting System: Analysis of 200 cases

    International Nuclear Information System (INIS)

    Ahmed, S.; Khan, M.A.; Kazi, F.

    2013-01-01

    Objective: To determine interobserver reproducibility of thyroid cytopathology in cases of thyroid fine needle aspirates. Methods: The retrospective, descriptive study, was conducted at the Foundation University Medical College, Islamabad, using cases related to period between 2009 and 2011. A total of 200 cases of fine-needle aspirations were retrieved from the archives. Three histopathologists independently categorised them into 6 groups according to Bethesda reporting system guidelines without looking at previous reports. Kappa statistics were used for analysis of the results on SPSS 17. Results: Of the 200 patients, 194 (97%) were females and 6 (3%) were males. The overall mean age of patients was 46+-20 years. Kappa value calculated for observer-1 and observer-2 was 0.735; for observer-1 and observer-3, 0.841; and for observer-2 and observer-3, 0.838, showing substantial interobserver agreement. Histopathological correlation was available, for 39(19.5%). Of these cases, 5(13%) were non-diagnostic, 20(51%) benign, 2(5%) atypia of undetermined significance/follicular lesion of undetermined significance, 6(15%) follicular neoplasm, 1(3%) suspicious for malignancy, and 5(13%) malignant. Conclusions: Good overall interobserver agreement was found, but discordance was seen when certain categories were analysed separately. (author)

  12. MD2036: UFO Dynamics Studies and UFO Fast Detection

    CERN Document Server

    Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

    2017-01-01

    UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

  13. Power of automated algorithms for combining time-line follow-back and urine drug screening test results in stimulant-abuse clinical trials.

    Science.gov (United States)

    Oden, Neal L; VanVeldhuisen, Paul C; Wakim, Paul G; Trivedi, Madhukar H; Somoza, Eugene; Lewis, Daniel

    2011-09-01

    In clinical trials of treatment for stimulant abuse, researchers commonly record both Time-Line Follow-Back (TLFB) self-reports and urine drug screen (UDS) results. To compare the power of self-report, qualitative (use vs. no use) UDS assessment, and various algorithms to generate self-report-UDS composite measures to detect treatment differences via t-test in simulated clinical trial data. We performed Monte Carlo simulations patterned in part on real data to model self-report reliability, UDS errors, dropout, informatively missing UDS reports, incomplete adherence to a urine donation schedule, temporal correlation of drug use, number of days in the study period, number of patients per arm, and distribution of drug-use probabilities. Investigated algorithms include maximum likelihood and Bayesian estimates, self-report alone, UDS alone, and several simple modifications of self-report (referred to here as ELCON algorithms) which eliminate perceived contradictions between it and UDS. Among the algorithms investigated, simple ELCON algorithms gave rise to the most powerful t-tests to detect mean group differences in stimulant drug use. Further investigation is needed to determine if simple, naïve procedures such as the ELCON algorithms are optimal for comparing clinical study treatment arms. But researchers who currently require an automated algorithm in scenarios similar to those simulated for combining TLFB and UDS to test group differences in stimulant use should consider one of the ELCON algorithms. This analysis continues a line of inquiry which could determine how best to measure outpatient stimulant use in clinical trials (NIDA. NIDA Monograph-57: Self-Report Methods of Estimating Drug Abuse: Meeting Current Challenges to Validity. NTIS PB 88248083. Bethesda, MD: National Institutes of Health, 1985; NIDA. NIDA Research Monograph 73: Urine Testing for Drugs of Abuse. NTIS PB 89151971. Bethesda, MD: National Institutes of Health, 1987; NIDA. NIDA Research

  14. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

    Science.gov (United States)

    Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

    2018-02-01

    Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

  15. STRATEGI PEMASARAN PUBLIC RELATIONS MD ENTERTAINMENT PADA PEMASARAN FILM HABIBIE & AINUN

    OpenAIRE

    Trisna Adi Permana; Lilis Puspitasari

    2015-01-01

    Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategi Marketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun 2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematis fakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitian menunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik...

  16. [Atypical urothelial cells (AUC): A Bethesda-derived wording applicable to urinary cytopathology].

    Science.gov (United States)

    Piaton, Eric; Advenier, Anne-Sophie; Benaïm, Gilles; Petrucci, Myriam Decaussin; Lechevallier, Florence Mege; Ruffion, Alain

    2011-02-01

    To investigate (1) whether sparse nuclear atypias involving deep urothelial cells have a diagnostic or prognostic value in urinary cytology, and (2) whether the terms atypical urothelial cells "of undetermined significance" (AUC-US) or "cannot exclude high grade" (AUC-H) might be used to standardize urinary cytology reports. Atypical urothelial cells (AUC) were defined as deep cells with nuclear abnormalities (increased N/C ratio, eccentric nucleus, hyperchromatism and/or irregular shape) in small number not allowing their categorization as malignant, high grade. We studied 435 urinary samples from 126 patients with AUC at any step of their clinical history, followed up over a 10-year period (1999-2009). Every case was compared with histopathology within 6 months and to long term follow-up including cystoscopy and histopathology combined. A total of 183 AUC was recorded. AUC were associated with negative, benign or low grade histological results in 36 of 106 cases (33.9 %) within 6 months, but a high grade was simultaneously documented in 70 cases (66 %). AUC preceded high-grade lesions in 66 cases (36.1 % of all AUC) in a mean interval of 10.5±12.0 months. Overall, AUC were associated with or predictive of high-grade lesions in 135 cases (73.8 %). AUC have a diagnostic and prognostic value. Applying the terms AUC-US and AUC-H to urinary cytopathology reports would allow, as for the Bethesda system for cervical or vaginal cytologic diagnoses, better appreciation of the risk of progression to high grade tumours in cases with atypias. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  17. MD 2179: Scraping of off-momentum halo after injection

    CERN Document Server

    Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

    2018-01-01

    In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

  18. InforMD: a new initiative to raise public awareness about breast density.

    Science.gov (United States)

    Hugo, Honor J; Zysk, Aneta; Dasari, Pallave; Britt, Kara; Hopper, John L; Stone, Jennifer; Thompson, Erik W; Ingman, Wendy V

    2018-01-01

    On a mammogram, breast density (also known as mammographic density) is shown as white and bright regions and is associated with reduced sensitivity in cancer detection and increased breast cancer risk. However, many Australian women are unaware of the significance of breast density as it is not routinely reported or discussed. In order to address this lack of knowledge, Australian breast cancer researchers with expertise in mammographic density formed the InforMD alliance (INformation FORum on Mammographic Density) in 2016. The alliance is working to raise awareness of breast density with the goal of improving breast cancer diagnosis and health outcomes for women. The InforMD website (www.InforMD.org.au) was launched in October 2016, coinciding with a major nationwide public awareness campaign by the alliance during breast cancer awareness month. The website contains unbiased, accurate, updated information on breast density. The website also provides summaries of major research articles in layperson language, recent news items related to breast density, links to relevant information for health professionals, events, and feature articles. Members of the public and health professionals can also subscribe for news updates. The interactive online Forum section facilitates discussion between health professionals, scientists and members of the public. To increase online traffic to the website, Facebook (www.facebook.com/BeInforMD) and Twitter (https://twitter.com/BeInforMD_) pages were launched in December 2016. Since its launch, InforMD has generated considerable interest. The public awareness campaign reached over 7 million Australians through a combination of newspaper, TV, radio, and online news. The website has attracted 13,058 unique visitors and 30,353 page views (data as of 19/12/2017). Breast cancer researchers have a significant role to play in disseminating information to the public on breast density. A combination of mainstream and social media, together with

  19. An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis.

    Science.gov (United States)

    Bai, Songling; Saito, Takanori; Honda, Chikako; Hatsuyama, Yoshimichi; Ito, Akiko; Moriguchi, Takaya

    2014-11-01

    Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Arabidopsis PAP1 is under the control of a series of upstream factors involved in light signal transduction and photomorphogenesis, such as ELONGATED HYPOCOTYL 5 (HY5) and B-box family (BBX) proteins. In this study, we identified and characterized the homolog of Arabidopsis BBX22 in apple, designated as MdCOL11. Overexpression of MdCOL11 in Arabidopsis enhanced the accumulation of anthocyanin. In apples, MdCOL11 was differentially expressed in all tissues, with the highest expression in petals and the lowest expression in the xylem. Transcripts of MdCOL11 noticeably accumulated at the ripening stage, concomitant with increases in the expressions of anthocyanin biosynthesis-related genes. In an in vitro treatment experiment, MdCOL11 was upregulated in an ultra-violet (UV)-B- and temperature-dependent manner, together with the inductions of anthocyanin biosynthesis-related genes and anthocyanin accumulation in apple peel. Furthermore, a dual-luciferase assay indicated that (1) MdCOL11 regulated the expression of MdMYBA and (2) MdCOL11 was a target of MdHY5. Taken together, our results suggest that MdCOL11 is involved in MdHY5-mediated signal transduction and regulates anthocyanin accumulation in apple peel, which sheds new light on anthocyanin accumulation in apples.

  20. Strategi Pemasaran Public Relations Md Entertainment Pada Pemasaran Film Habibie & Ainun

    OpenAIRE

    Permana, Trisna Adi; Puspitasari, Lilis

    2015-01-01

    Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategiMarketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematisfakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitianmenunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik PR pada film Ha...